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Ingenuity Pathway Analysis Results for P1

Analysis Settings
Cutoff before duplicate resolution	true
Resolve duplicate on	Expression logfoldchange
Color using	Expression logfoldchange
Cutoff for Expression logfoldchange	0.5	and consider Both up/down regulated
Reference set	Ingenuity Knowledge Base (Genes Only)
Relationship to include	Direct and Indirect
Includes Endogenous Chemicals	Yes
Optional Analyses	My Pathways My List
Filter Summary	
Consider only molecules and/or relationships where
(confidence = Experimentally Observed) AND
(mol. types = biologic drug OR chemical - endogenous mammalian OR chemical - endogenous non-mammalian OR chemical - kinase inhibitor OR chemical - other OR chemical - protease inhibitor OR chemical drug OR chemical reagent OR chemical toxicant OR complex OR cytokine OR disease OR enzyme OR function OR G-protein coupled receptor OR group OR growth factor OR ion channel OR kinase OR ligand-dependent nuclear receptor OR mature microRNA OR microRNA OR other OR peptidase OR phosphatase OR transcription regulator OR translation regulator OR transmembrane receptor OR transporter)

Canonical Pathways for My Projects->David Bulger->P1
Ingenuity Canonical Pathways	 -log(p-value)	zScore	Ratio	Molecules
1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian)	-0E00	NaN	1.05E-01	ITPK1,INPPL1	
4-1BB Signaling in T Lymphocytes	-0E00	NaN	1.29E-01	IKBKG,NFKBIA,JUN,MAP2K2	
Activation of IRF by Cytosolic Pattern Recognition Receptors	-0E00	0.3779644730092272	1.13E-01	IKBKG,NFKBIA,JUN,IL6,IRF3,PIN1,IFIT2	
Adenosine Nucleotides Degradation II	-0E00	NaN	1.18E-01	NT5C,AOX1	
Allograft Rejection Signaling	-0E00	NaN	8.33E-02	HLA-G,HLA-DOA,HLA-DRB1,HLA-DRB4,FCER1G,CD86,HLA-F	
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	-0E00	NaN	6.82E-02	HLA-DOA,HLA-DRB1,SPP1,FCER1G,CD86,IL6	
Antiproliferative Role of TOB in T Cell Signaling	-0E00	NaN	1.15E-01	TGFBR2,TOB1,CDC34	
April Mediated Signaling	-0E00	0.4472135954999579	1.32E-01	FOS,IKBKG,NFKBIA,JUN,ELK1	
Assembly of RNA Polymerase II Complex	-0E00	NaN	1.40E-01	POLR2I,POLR2G,TAF6,POLR2H,TAF10,ERCC2,TAF9B	
B Cell Activating Factor Signaling	-0E00	NaN	1.25E-01	FOS,IKBKG,NFKBIA,JUN,ELK1	
B Cell Development	-0E00	NaN	9.09E-02	HLA-DOA,HLA-DRB1,CD86	
CD28 Signaling in T Helper Cells	-0E00	0.5773502691896258	1.44E-01	FYN,PIK3C2B,HLA-DOA,ARPC5L,ITPR2,CD4,CSK,FOS,IKBKG,HLA-DRB1,NFKBIA,JUN,MAP2K2,WAS,FCER1G,CD86,PIK3R2	
Calcium Signaling	-0E00	1.414213562373095	1.35E-01	CAMK1,ITPR2,ATP2C1,ATP2B1,MYL5,MYL6B,TPM1,MYH11,CREB5,PNCK,ATP2A2,SLC8B1,GRINA,RCAN1,MICU1,CAMK2D,HDAC11,ATF4,ASPH,RCAN2,ACTA1,CASQ2,MYL3,MYH1	
Calcium-induced T Lymphocyte Apoptosis	-0E00	0.8164965809277261	1.41E-01	HLA-DOA,HLA-DRB1,ITPR2,CD4,PRKCD,FCER1G,PRKCE,CAPN2,ATP2A2	
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	-0E00	0.0	1.22E-01	KAT2B,GADD45A,PTPMT1,ABL1,HIPK2,CHEK2	
Cellular Effects of Sildenafil (Viagra)	-0E00	NaN	1.24E-01	GUCY1A3,ITPR2,SLC4A11,MYL5,PPP1CB,MYL6B,MYLK,MYH11,PLCE1,PDE3B,PDE1B,ADCY1,ACTG2,MYL3,ACTA1,MYH1	
Chondroitin Sulfate Biosynthesis	-0E00	NaN	1.43E-01	B4GALT7,B3GALT6,XYLT2,CHPF,HS2ST1,NDST2,B3GAT3,HS3ST3A1	
Chondroitin Sulfate Biosynthesis (Late Stages)	-0E00	NaN	8.33E-02	CHPF,HS2ST1,NDST2,HS3ST3A1	
Coagulation System	-0E00	-1.3416407864998738	1.43E-01	F8,F13A1,PLAUR,THBD,PLAT	
Communication between Innate and Adaptive Immune Cells	-0E00	NaN	1.24E-01	HLA-G,CXCL8,HLA-DRB1,HLA-DRB4,CCL3L3,CD4,FCER1G,CD86,IL6,CCL3,HLA-F	
Corticotropin Releasing Hormone Signaling	-0E00	0.5773502691896258	1.35E-01	GUCY1A3,ITPR2,GNAI1,POMC,CREB5,FOS,JUN,MAP2K2,PRKCD,ADCY1,SMO,PRKCE,ATF4,PTGS2,ELK1	
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells	-0E00	NaN	3.12E-02	FCER1G,	
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis	-0E00	NaN	5.26E-02	INPPL1,	
D-myo-inositol (1,4,5)-trisphosphate Degradation	-0E00	NaN	1.11E-01	IMPA2,INPPL1	
DNA Double-Strand Break Repair by Non-Homologous End Joining	-0E00	NaN	7.14E-02	LIG3,	
DNA Methylation and Transcriptional Repression Signaling	-0E00	NaN	1.00E-01	MBD3,MBD2	
Dendritic Cell Maturation	-0E00	1.0425720702853738	1.41E-01	HLA-DOA,LEP,LEPR,IL6,COL1A2,IKBKG,HLA-DRB1,PLCE1,NFKBIA,ATF4,PIK3R2,LTBR,COL18A1,CD1C,FCGR3A/FCGR3B,PIK3C2B,TYROBP,CREB5,COL1A1,COL5A3,HLA-DRB4,FSCN1,FCER1G,CD86,COL3A1	
Dermatan Sulfate Biosynthesis	-0E00	NaN	1.36E-01	B4GALT7,B3GALT6,XYLT2,CHPF,HS2ST1,NDST2,B3GAT3,HS3ST3A1	
Dermatan Sulfate Biosynthesis (Late Stages)	-0E00	NaN	6.52E-02	HS2ST1,NDST2,HS3ST3A1	
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F	-0E00	NaN	1.30E-01	CCL2,DEFB1,CCL3	
Docosahexaenoic Acid (DHA) Signaling	-0E00	NaN	1.03E-01	PIK3C2B,BCL2L1,GSK3B,PIK3R2	
Dopamine-DARPP32 Feedback in cAMP Signaling	-0E00	0.24253562503633297	1.43E-01	KCNJ8,GUCY1A3,KCNJ2,ITPR2,PPP1R1B,PPP1R3C,GNAI1,PPP1CB,PPP2R3B,PPP1R14A,PAWR,PPP1R11,CREB5,PPP1R14B,ATP2A2,GRINA,PPP2R1A,PLCE1,PTPA,PRKCD,ADCY1,ATF4,PRKCE	
Embryonic Stem Cell Differentiation into Cardiac Lineages	-0E00	NaN	1.00E-01	MESP1,	
Ephrin A Signaling	-0E00	NaN	8.33E-02	PIK3C2B,FYN,VAV3,PIK3R2	
Estrogen-mediated S-phase Entry	-0E00	NaN	1.25E-01	MYC,CDK4,ESR1	
Extrinsic Prothrombin Activation Pathway	-0E00	NaN	1.25E-01	F13A1,THBD	
FGF Signaling	-0E00	1.0	1.06E-01	PIK3C2B,FGF2,SOS1,HRAS,ATF4,MAP2K3,PIK3R2,CREB5,MAPKAPK2	
GABA Receptor Signaling	-0E00	NaN	1.34E-01	NSF,AP2M1,ADCY1,AP1B1,GABARAP,AP2A2,GABRE,AP2S1,ALDH5A1	
GDP-glucose Biosynthesis	-0E00	NaN	1.43E-01	HK1,	
GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell	-0E00	NaN	9.86E-02	PLCE1,GNA15,ITPR2,GNA11,ADCY1,GNAI1,ADRB2	
Gustation Pathway	-0E00	NaN	9.92E-02	GNG11,ITPR2,PDE3B,P2RX4,PDE1B,ADCY1,GNG2,ASIC1,PDE8B,GNG5,P2RX7,MPPE1	
Gαs Signaling	-0E00	0.0	1.38E-01	HCAR3,SRC,GNG2,LHCGR,CREB5,GNG10,GNG11,MAP2K2,ADCY1,ATF4,GNG5,ELK1,HCAR2,PTGER4,ADRB2	
Hematopoiesis from Pluripotent Stem Cells	-0E00	NaN	8.51E-02	CXCL8,CD4,FCER1G,IL6	
Heparan Sulfate Biosynthesis (Late Stages)	-0E00	NaN	1.15E-01	AADAC,HS2ST1,LIPE,EXTL3,NDST2,HS3ST3A1	
Hepatic Cholestasis	-0E00	NaN	1.43E-01	CXCL8,TJP2,SLC4A2,CYP27A1,IL6,IRAK1,IL18RAP,LY96,IKBKG,NFKBIA,JUN,IL17D,RARA,PRKCD,ABCC1,PPRC1,ADCY1,NR5A2,PRKCE,CD14,LBP,ABCC3,ESR1	
IL-15 Production	-0E00	NaN	1.11E-01	IL6,IRF3,PTK7	
IL-17A Signaling in Airway Cells	-0E00	0.7071067811865475	1.25E-01	PIK3C2B,IKBKG,NFKBIA,MAP2K2,IL17RC,GSK3B,IL6,PIK3R2	
IL-22 Signaling	-0E00	NaN	4.17E-02	SOCS3,	
Interferon Signaling	-0E00	NaN	2.78E-02	IFNAR2,	
Leptin Signaling in Obesity	-0E00	0.0	1.35E-01	PIK3C2B,SOCS3,PLCE1,LEP,MAP2K2,LEPR,PDE3B,ADCY1,POMC,PIK3R2	
Maturity Onset Diabetes of Young (MODY) Signaling	-0E00	NaN	4.76E-02	GAPDH,	
Melanoma Signaling	-0E00	NaN	1.43E-01	PIK3C2B,RRAS2,MAP2K2,CDK4,HRAS,PIK3R2	
Melatonin Degradation I	-0E00	NaN	1.40E-01	LARGE1,POR,CYP4B1,CYP4X1,B3GAT3,CYP1B1,CYP51A1,CYP2C8	
Melatonin Signaling	-0E00	0.0	1.14E-01	CAMK2D,PLCE1,MAP2K2,PRKCD,GNAI1,PRKCE,MAP2K3,MAP2K5	
Mitotic Roles of Polo-Like Kinase	-0E00	0.0	1.36E-01	SLK,PPP2R1A,CDC20,PTPA,PTTG1,PPP2R3B,CDC16,RAD21,CHEK2	
Myc Mediated Apoptosis Signaling	-0E00	NaN	1.21E-01	MYC,PIK3C2B,SHC1,RRAS2,SOS1,HRAS,PIK3R2	
NAD Salvage Pathway III	-0E00	NaN	1.43E-01	NMNAT2,	
NF-κB Signaling	-0E00	1.2247448713915892	1.40E-01	PIK3C2B,BMP4,BMP2,TGFBR3,HRAS,TNFAIP3,NGF,IGF2R,IRAK1,TGFBR2,TNIP1,IKBKG,NFKBIA,RRAS2,NTRK3,PELI1,FCER1G,MAP3K8,GSK3B,CSNK2B,LTBR,PIK3R2,KDR,MAP4K4	
Netrin Signaling	-0E00	NaN	5.13E-02	UNC5B,ENAH	
Neuropathic Pain Signaling In Dorsal Horn Neurons	-0E00	0.5773502691896258	1.20E-01	FOS,PIK3C2B,SRC,CAMK2D,CAMK1,PLCE1,ITPR2,PRKCD,PRKCE,PIK3R2,ELK1,GRINA	
Nur77 Signaling in T Lymphocytes	-0E00	NaN	1.23E-01	HLA-DOA,HLA-DRB1,SIN3B,FCER1G,CD86,MAPK7,MAP2K5	
OX40 Signaling Pathway	-0E00	0.0	1.24E-01	HLA-G,BCL2L1,HLA-DOA,HLA-DRB1,NFKBIA,HLA-DRB4,JUN,TNFRSF4,CD4,FCER1G,HLA-F	
PEDF Signaling	-0E00	1.414213562373095	1.27E-01	PIK3C2B,BCL2L1,IKBKG,NFKBIA,RRAS2,HRAS,PIK3R2,ELK1,NGF	
PPAR Signaling	-0E00	0.2773500981126146	1.40E-01	HRAS,IL18RAP,SHC1,FOS,IKBKG,NFKBIA,JUN,RRAS2,MAP2K2,SOS1,PTGS2,PDGFD,MAP4K4	
PXR/RXR Activation	-0E00	NaN	1.36E-01	GSTM1,ALDH1A1,GSTM2,PCK2,ALDH3A2,IL6,CES2,ABCC3,CYP2C8	
Parkinson's Signaling	-0E00	NaN	6.25E-02	UCHL1,	
Phosphatidylethanolamine Biosynthesis II	-0E00	NaN	1.11E-01	PCYT2,	
Phospholipases	-0E00	NaN	1.38E-01	PLA2G4A,HMOX1,PLCE1,PLD3,PLA2G5,RARRES3,LIPG,PLA2G2A	
Phototransduction Pathway	-0E00	NaN	1.89E-02	GUCY1A3,	
Primary Immunodeficiency Signaling	-0E00	NaN	1.04E-01	RFXANK,BTK,IKBKG,CD4,UNG	
RANK Signaling in Osteoclasts	-0E00	0.30151134457776363	1.36E-01	FOS,PIK3C2B,SRC,MAP3K12,IKBKG,NFKBIA,JUN,MAP2K2,MAP3K8,PIK3R2,ELK1,BIRC3	
Rac Signaling	-0E00	2.138089935299395	1.35E-01	PIK3C2B,NOX4,PAK4,ARPC5L,HRAS,ITGA3,JUN,RRAS2,MAP2K2,PIP5K1C,NCF2,PIK3R2,ELK1,PI4KA	
Role of BRCA1 in DNA Damage Response	-0E00	2.4494897427831783	1.41E-01	FANCE,FAAP100,GADD45A,FANCG,SMARCB1,RBBP8,SLC19A1,RPA1,BABAM1,BRE,CHEK2	
Role of CHK Proteins in Cell Cycle Checkpoint Control	-0E00	2.0	1.27E-01	PPP2R1A,PTPA,ATMIN,SLC19A1,PPP2R3B,RPA1,CHEK2	
Role of Cytokines in Mediating Communication between Immune Cells	-0E00	NaN	3.70E-02	CXCL8,IL6	
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza	-0E00	NaN	1.16E-01	CCR1,CXCL8,CCL2,IL6,CCL3	
Role of JAK family kinases in IL-6-type Cytokine Signaling	-0E00	NaN	8.00E-02	SOCS3,IL6	
Role of JAK1 and JAK3 in γc Cytokine Signaling	-0E00	NaN	1.13E-01	PIK3C2B,SOCS3,SHC1,RRAS2,HRAS,IRS2,PIK3R2	
Role of JAK1, JAK2 and TYK2 in Interferon Signaling	-0E00	NaN	4.17E-02	IFNAR2,	
Role of JAK2 in Hormone-like Cytokine Signaling	-0E00	NaN	1.18E-01	SOCS3,SHC1,SOCS2,IRS2	
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency	-0E00	NaN	1.30E-01	SPP1,ETS2,RARA,NR5A2,SH3GLB1,NR2F6	
Role of PI3K/AKT Signaling in the Pathogenesis of Influenza	-0E00	0.3779644730092272	1.11E-01	PIK3C2B,NFKBIA,MAP2K2,GNAI1,GSK3B,IRF3,PIK3R2	
Role of PKR in Interferon Induction and Antiviral Response	-0E00	NaN	7.50E-02	IKBKG,NFKBIA,MAP2K3	
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses	-0E00	0.30151134457776363	1.12E-01	PTX3,CXCL8,PIK3C2B,NLRP3,C5AR1,C1QC,C1QA,IL6,C1QB,IRF3,IL17D,PRKCD,PRKCE,PIK3R2	
Role of RIG1-like Receptors in Antiviral Innate Immunity	-0E00	NaN	6.98E-02	IKBKG,NFKBIA,IRF3	
Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza	-0E00	1.6666666666666667	1.32E-01	DVL2,AXIN1,SMO,DVL3,FZD5,FZD9,GSK3B,FZD2,WNT5B,FZD7	
Role of p14/p19ARF in Tumor Suppression	-0E00	NaN	1.00E-01	PIK3C2B,NPM3,PIK3R2	
Serotonin Receptor Signaling	-0E00	NaN	1.14E-01	SMOX,PTS,ADCY1,PCBD1,MAOA	
Sonic Hedgehog Signaling	-0E00	1.0	1.33E-01	STK36,ADRBK1,SMO,GSK3B	
Sperm Motility	-0E00	0.5773502691896258	1.16E-01	GUCY1A3,ITPR2,ZP3,SLC12A2,CACNA1H,PLA2G2A,PLA2G4A,PLCE1,PRKCD,PDE1B,PLA2G5,RARRES3,PRKCE,PTK7	
Sphingomyelin Metabolism	-0E00	NaN	1.25E-01	SMPD1,	
Sphingosine-1-phosphate Signaling	-0E00	-1.0690449676496976	1.28E-01	RND2,PIK3C2B,GNAI1,CASP4,SMPD1,S1PR3,PLCE1,RHOB,RHOD,ADCY1,S1PR1,RHOU,PIK3R2,PDGFD	
Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism	-0E00	NaN	8.33E-02	IMPA2,INPPL1	
Synaptic Long Term Depression	-0E00	-0.4472135954999579	1.41E-01	GUCY1A3,ITPR2,GNA11,GNAI1,PPP2R3B,HRAS,GNAZ,PLA2G2A,PLA2G4A,PPP2R1A,PLCE1,RRAS2,GNA15,MAP2K2,PTPA,PRKCD,PLA2G5,LYN,RARRES3,PRKCE	
Systemic Lupus Erythematosus Signaling	-0E00	NaN	1.36E-01	RNVU1-7,PRPF19,HRAS,IL6,RNU1-3,HLA-G,MTOR,JUN,SOS1,C7,SNU13,PIK3R2,LSM10,HLA-F,PRPF31,FCGR3A/FCGR3B,LSM4,PIK3C2B,SNRPB,RNU4-2,RNU4-1,FOS,PPIH,RRAS2,LYN,FCER1G,CD86,LSM7,C6	
T Helper Cell Differentiation	-0E00	NaN	9.86E-02	TGFBR2,HLA-DOA,HLA-DRB1,FCER1G,IL10RA,CD86,IL6	
TNFR1 Signaling	-0E00	0.0	1.43E-01	FOS,IKBKG,PAK4,NFKBIA,JUN,TNFAIP3,BIRC3	
TREM1 Signaling	-0E00	-0.7071067811865475	1.07E-01	CXCL8,NLRP3,CCL2,TYROBP,CD86,IL6,CCL3,IRAK1	
TWEAK Signaling	-0E00	2.0	1.18E-01	IKBKG,NFKBIA,BIRC3,TNFRSF12A	
Thyroid Hormone Metabolism II (via Conjugation and/or Degradation)	-0E00	NaN	5.71E-02	LARGE1,B3GAT3	
Transcriptional Regulatory Network in Embryonic Stem Cells	-0E00	NaN	2.50E-02	FOXC1,	
Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde	-0E00	NaN	1.25E-01	IDO1,	
Tumoricidal Function of Hepatic Natural Killer Cells	-0E00	NaN	8.33E-02	SRGN,LYVE1	
Type I Diabetes Mellitus Signaling	-0E00	1.889822365046136	1.18E-01	SOCS3,HLA-DOA,ICA1,IRAK1,HLA-G,IKBKG,NFKBIA,HLA-DRB1,FCER1G,SOCS2,CD86,MAP2K3,HLA-F	
VDR/RXR Activation	-0E00	NaN	1.28E-01	IGFBP6,SPP1,GADD45A,PRKCD,IGFBP3,CD14,PRKCE,SEMA3B,THBD,KLF4	
Valine Degradation I	-0E00	NaN	1.11E-01	BCAT2,HADHA	
cAMP-mediated signaling	-0E00	-1.299867367239363	1.37E-01	AKAP12,HCAR3,CAMK1,ADRBK1,LHCGR,RGS12,MPPE1,CAMK2D,MAP2K2,PDE3B,ATF4,PKIA,ADORA1,HCAR2,PTGER4,ADRB2,SRC,APLNR,GNAI1,CREB5,S1PR3,LPAR1,NPR3,ADRA2A,RAP1GAP,DUSP1,PDE1B,ADCY1,S1PR1,PDE8B	
iCOS-iCOSL Signaling in T Helper Cells	-0E00	1.1338934190276817	1.20E-01	PIK3C2B,HLA-DOA,ITPR2,CD4,CSK,SHC1,IKBKG,HLA-DRB1,CAMK2D,NFKBIA,FCER1G,PIK3R2,PLEKHA2	
nNOS Signaling in Skeletal Muscle Cells	-0E00	NaN	1.33E-01	SNTB1,SNTA1	
Arginine Biosynthesis IV	2.16E-01	NaN	1.67E-01	ASS1,	
Chondroitin and Dermatan Biosynthesis	2.16E-01	NaN	1.67E-01	CHPF,	
Glycine Cleavage Complex	2.16E-01	NaN	1.67E-01	GCSH,	
NAD Biosynthesis III	2.16E-01	NaN	1.67E-01	NMNAT2,	
Choline Biosynthesis III	2.36E-01	NaN	1.54E-01	HMOX1,PLD3	
Guanosine Nucleotides Degradation III	2.36E-01	NaN	1.54E-01	NT5C,AOX1	
Oleate Biosynthesis II (Animals)	2.36E-01	NaN	1.54E-01	CYB5A,PTPRT	
Cardiomyocyte Differentiation via BMP Receptors	2.45E-01	NaN	1.50E-01	BMP4,BMP2,SMAD6	
Granzyme A Signaling	2.45E-01	NaN	1.50E-01	HIST1H1C,NME1,H1F0	
Purine Nucleotides Degradation II (Aerobic)	2.45E-01	NaN	1.50E-01	IMPDH2,NT5C,AOX1	
Cell Cycle Control of Chromosomal Replication	2.5E-01	NaN	1.48E-01	MCM2,CDK4,RPA1,CHEK2	
IL-9 Signaling	2.53E-01	0.0	1.47E-01	PIK3C2B,SOCS3,SOCS2,IRS2,PIK3R2	
Graft-versus-Host Disease Signaling	2.57E-01	NaN	1.46E-01	HLA-G,HLA-DOA,HLA-DRB1,FCER1G,CD86,IL6,HLA-F	
Role of MAPK Signaling in the Pathogenesis of Influenza	2.6E-01	NaN	1.45E-01	PLA2G4A,RRAS2,MAP2K2,CCL2,PLA2G5,HRAS,RARRES3,MAP2K3,PTGS2,PLA2G2A	
BMP signaling pathway	2.61E-01	-0.9045340337332909	1.45E-01	RRAS2,FST,BMP4,JUN,MAP2K2,BMP2,SOS1,SMAD6,SMAD7,HRAS,BMP6	
HER-2 Signaling in Breast Cancer	2.61E-01	NaN	1.45E-01	PIK3C2B,RRAS2,PRKCD,SOS1,TSC2,HRAS,PRKCE,MMP2,GSK3B,ERBB2,PIK3R2	
CMP-N-acetylneuraminate Biosynthesis I (Eukaryotes)	2.66E-01	NaN	2.00E-01	NAGK,	
Ceramide Biosynthesis	2.66E-01	NaN	2.00E-01	SPTLC2,	
Citrulline-Nitric Oxide Cycle	2.66E-01	NaN	2.00E-01	ASS1,	
Creatine-phosphate Biosynthesis	2.66E-01	NaN	2.00E-01	MAP4K4,	
Glutamate Degradation III (via 4-aminobutyrate)	2.66E-01	NaN	2.00E-01	ALDH5A1,	
Lactose Degradation III	2.66E-01	NaN	2.00E-01	GLB1,	
Protein Citrullination	2.66E-01	NaN	2.00E-01	PADI4,	
Serine Biosynthesis	2.66E-01	NaN	2.00E-01	PSAT1,	
dTMP De Novo Biosynthesis	2.66E-01	NaN	2.00E-01	SHMT2,	
Acyl-CoA Hydrolysis	2.71E-01	NaN	1.67E-01	ACOT4,ACOT7	
BER pathway	2.71E-01	NaN	1.67E-01	LIG1,LIG3	
D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis	2.75E-01	NaN	1.54E-01	PLCE1,PIP5K1C,PI4KA,PI4KB	
Lymphotoxin β Receptor Signaling	2.76E-01	1.889822365046136	1.48E-01	DIABLO,PIK3C2B,BCL2L1,VCAM1,IKBKG,NFKBIA,PIK3R2,LTBR	
Autoimmune Thyroid Disease Signaling	2.76E-01	NaN	1.49E-01	HLA-G,HLA-DOA,HLA-DRB1,FCER1G,CD86,TPO,HLA-F	
Induction of Apoptosis by HIV1	2.94E-01	1.6666666666666667	1.50E-01	DIABLO,BCL2L1,SLC25A13,IKBKG,NFKBIA,SLC25A6,CXCR4,SLC25A10,BIRC3	
MSP-RON Signaling Pathway	2.96E-01	NaN	1.52E-01	PIK3C2B,ITGAM,CCL2,MST1,ACTG2,PIK3R2,ACTA1	
Hereditary Breast Cancer Signaling	2.98E-01	NaN	1.47E-01	POLR2I,PIK3C2B,FAAP100,GADD45B,FANCG,TUBG1,CDK4,POLR2H,HRAS,RPA1,FANCE,POLR2G,RRAS2,GADD45A,HDAC11,SMARCB1,SLC19A1,PIK3R2,CHEK2	
IL-17A Signaling in Gastric Cells	3.02E-01	NaN	1.60E-01	FOS,CXCL8,JUN,IL17RC	
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F	3.06E-01	NaN	1.67E-01	CCL2,IL6,CCL3	
Notch Signaling	3.21E-01	0.0	1.58E-01	ADAM17,NCSTN,HEY2,NOTCH1,HEY1,RFNG	
2-ketoglutarate Dehydrogenase Complex	3.33E-01	NaN	2.50E-01	DHTKD1,	
Fatty Acid β-oxidation III (Unsaturated, Odd Number)	3.33E-01	NaN	2.50E-01	ECI1,	
Heme Degradation	3.33E-01	NaN	2.50E-01	HMOX1,	
Myo-inositol Biosynthesis	3.33E-01	NaN	2.50E-01	IMPA2,	
Phenylalanine Degradation I (Aerobic)	3.33E-01	NaN	2.50E-01	PCBD1,	
Retinoate Biosynthesis II	3.33E-01	NaN	2.50E-01	RBP5,	
Spermine and Spermidine Degradation I	3.33E-01	NaN	2.50E-01	SMOX,	
Thymine Degradation	3.33E-01	NaN	2.50E-01	DPYD,	
Uracil Degradation II (Reductive)	3.33E-01	NaN	2.50E-01	DPYD,	
FXR/RXR Activation	3.37E-01	NaN	1.51E-01	APOE,APOB,SLC4A2,CYP27A1,SAA2,SAA4,G6PC3,TF,ORM1,PCK2,RARA,SAA1,APOC1,NR5A2,ORM2,FBP1,PLTP,RBP4,AGT	
Cyclins and Cell Cycle Regulation	3.4E-01	0.3333333333333333	1.54E-01	PPP2R1A,CCND2,PA2G4,CCND3,PTPA,HDAC11,ABL1,CDK4,PPP2R3B,CDKN2C,GSK3B,CDKN2B	
Mitochondrial L-carnitine Shuttle Pathway	3.42E-01	NaN	1.76E-01	ACSL3,ACSL4,SLC27A1	
Small Cell Lung Cancer Signaling	3.44E-01	NaN	1.55E-01	MYC,PIK3C2B,BCL2L1,IKBKG,NFKBIA,PA2G4,ABL1,CDK4,PTGS2,PIK3R2,CDKN2B	
Amyotrophic Lateral Sclerosis Signaling	3.48E-01	NaN	1.53E-01	PRPH,CAPN5,PIK3C2B,CAPN6,VEGFC,GRINA,BCL2L1,RAB5A,CAPNS1,CAT,GLUL,VEGFD,CAPN2,PIK3R2,BIRC3	
Role of NFAT in Cardiac Hypertrophy	3.58E-01	1.0	1.51E-01	CAMK1,HRAS,IL6,TGFBR2,SHC1,CAMK2D,PLCE1,GNG11,MAP2K2,HDAC11,SOS1,PRKCE,PIK3R2,GSK3B,GNG5,SRC,PIK3C2B,ITPR2,GNG2,GNAI1,GNG10,RCAN1,RRAS2,PRKCD,ADCY1,MAP2K3,RCAN2	
Glycine Betaine Degradation	3.61E-01	NaN	2.00E-01	SHMT2,SDSL	
Histidine Degradation VI	3.61E-01	NaN	2.00E-01	CYP11A1,CYP4F11	
TCA Cycle II (Eukaryotic)	3.66E-01	NaN	1.74E-01	SUCLA2,CS,DHTKD1,ACO2	
IL-15 Signaling	3.68E-01	NaN	1.59E-01	PIK3C2B,BCL2L1,SHC1,CXCL8,VCAM1,RRAS2,MAP2K2,HRAS,IL6,PIK3R2	
Natural Killer Cell Signaling	3.73E-01	NaN	1.55E-01	FYN,PIK3C2B,PAK4,TYROBP,HRAS,INPPL1,SHC1,RRAS2,MAP2K2,PRKCD,VAV3,SOS1,FCER1G,PRKCE,PIK3R2,HCST,FCGR3A/FCGR3B	
autophagy	3.74E-01	NaN	1.67E-01	VPS18,LAMP2,MTOR,ATG7,ATG9A,SQSTM1	
CDP-diacylglycerol Biosynthesis I	3.83E-01	NaN	1.88E-01	GPAM,ABHD5,LCLAT1	
Chondroitin Sulfate Degradation (Metazoa)	3.83E-01	NaN	1.88E-01	GM2A,HYAL1,HEXA	
Mismatch Repair in Eukaryotes	3.83E-01	NaN	1.88E-01	SLC19A1,RPA1,POLD1	
Growth Hormone Signaling	3.83E-01	1.507556722888818	1.59E-01	FOS,PIK3C2B,SOCS3,PRKCD,RPS6KB2,IGFBP3,SOCS2,PRKCE,RPS6KA4,PIK3R2,ELK1	
Renin-Angiotensin Signaling	3.89E-01	0.7276068751089989	1.56E-01	PIK3C2B,PAK4,ITPR2,HRAS,FOS,SHC1,RRAS2,JUN,CCL2,MAP2K2,PRKCD,ADCY1,SOS1,PRKCE,PIK3R2,ELK1,AGT	
phagosome formation	3.89E-01	NaN	1.56E-01	RND2,PIK3C2B,FCER1A,INPPL1,ITGA3,PLCE1,RHOB,SCARA3,RHOD,PRKCD,FCER1G,RHOU,PRKCE,PIK3R2,FCGR3A/FCGR3B,FCER2,MARCO	
Superpathway of Melatonin Degradation	3.9E-01	NaN	1.61E-01	LARGE1,POR,SMOX,CYP4B1,CYP4X1,B3GAT3,CYP1B1,CYP51A1,MAOA,CYP2C8	
Nucleotide Excision Repair Pathway	4.03E-01	NaN	1.71E-01	POLR2I,POLR2G,ERCC1,POLR2H,RPA1,ERCC2	
Relaxin Signaling	4.03E-01	0.5773502691896258	1.56E-01	PIK3C2B,GUCY1A3,GNA11,GNG2,GNAI1,GNAZ,MPPE1,GNG10,FOS,NFKBIA,GNG11,JUN,GNA15,PDE3B,PDE1B,ADCY1,PDE8B,PIK3R2,GNG5,ELK1,MMP9	
CTLA4 Signaling in Cytotoxic T Lymphocytes	4.04E-01	NaN	1.59E-01	FYN,PIK3C2B,AP2M1,AP1S2,CLTB,PPP2R3B,AP1B1,AP2A2,AP2S1,PPP2R1A,PTPA,FCER1G,CD86,PIK3R2	
Toll-like Receptor Signaling	4.18E-01	1.8973665961010275	1.62E-01	FOS,IKBKG,LY96,NFKBIA,JUN,CD14,TNFAIP3,MAP2K3,LBP,ELK1,MAP4K4,IRAK1	
Assembly of RNA Polymerase I Complex	4.18E-01	NaN	2.22E-01	POLR1C,TAF1C	
Pathogenesis of Multiple Sclerosis	4.18E-01	NaN	2.22E-01	CCR1,CCL3	
Nicotine Degradation III	4.22E-01	NaN	1.67E-01	LARGE1,POR,CYP4B1,CYP4X1,AOX1,B3GAT3,CYP1B1,CYP51A1,CYP2C8	
1D-myo-inositol Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3)	4.27E-01	NaN	3.33E-01	ITPK1,	
4-aminobutyrate Degradation I	4.27E-01	NaN	3.33E-01	ALDH5A1,	
Coenzyme A Biosynthesis	4.27E-01	NaN	3.33E-01	COASY,	
Hypusine Biosynthesis	4.27E-01	NaN	3.33E-01	DHPS,	
L-serine Degradation	4.27E-01	NaN	3.33E-01	SDSL,	
Methylglyoxal Degradation I	4.27E-01	NaN	3.33E-01	HAGH,	
Tetrahydrobiopterin Biosynthesis I	4.27E-01	NaN	3.33E-01	PTS,	
Tetrahydrobiopterin Biosynthesis II	4.27E-01	NaN	3.33E-01	PTS,	
Trehalose Degradation II (Trehalase)	4.27E-01	NaN	3.33E-01	HK1,	
Tyrosine Biosynthesis IV	4.27E-01	NaN	3.33E-01	PCBD1,	
Nitric Oxide Signaling in the Cardiovascular System	4.29E-01	-1.0690449676496976	1.60E-01	PIK3C2B,GUCY1A3,ITPR2,SLC7A1,VEGFC,ARG2,ATP2A2,MAP2K2,PDE3B,PRKCD,PDE1B,CAV1,VEGFD,PRKCE,PIK3R2,KDR	
IL-12 Signaling and Production in Macrophages	4.35E-01	NaN	1.58E-01	PIK3C2B,APOE,APOB,MAF,MST1,SAA4,SPI1,FOS,IKBKG,LYZ,JUN,ORM1,MAP2K2,PRKCD,APOC1,PRKCE,ORM2,MAP3K8,S100A8,PIK3R2,RBP4	
Chronic Myeloid Leukemia Signaling	4.36E-01	NaN	1.61E-01	PIK3C2B,PA2G4,MECOM,CDK4,ABL1,HRAS,MYC,TGFBR2,BCL2L1,IKBKG,RRAS2,MAP2K2,HDAC11,SOS1,PIK3R2	
NF-κB Activation by Viruses	4.4E-01	NaN	1.64E-01	PIK3C2B,ITGA3,IKBKG,NFKBIA,RRAS2,CD4,PRKCD,HRAS,PRKCE,ITGA1,PIK3R2,TNFRSF14	
Regulation of eIF4 and p70S6K Signaling	4.41E-01	0.5773502691896258	1.58E-01	PIK3C2B,EIF3C,EIF4EBP2,PPP2R3B,HRAS,RPS21,EIF2S2,EIF4EBP1,SHC1,PPP2R1A,ITGA3,MTOR,RRAS2,EIF3B,EIF4EBP3,MAP2K2,PTPA,RPS27L,SOS1,RPS2,PIK3R2,RPS24,EIF3K	
Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I	4.42E-01	NaN	1.90E-01	NME1,AK1,RRM2B,AK4	
HIPPO signaling	4.44E-01	-1.1338934190276817	1.63E-01	TJP2,PPP1R3C,PPP1CB,PPP2R3B,MST1,PPP1R14A,PPP1R11,PPP1R14B,PPP2R1A,PTPA,LLGL1,AJUBA,SCRIB,DLG4	
P2Y Purigenic Receptor Signaling Pathway	4.46E-01	0.47140452079103173	1.60E-01	PIK3C2B,GNG2,GNAI1,HRAS,CREB5,GNG10,MYC,FOS,GNG11,JUN,PLCE1,RRAS2,MAP2K2,PRKCD,ADCY1,PRKCE,ATF4,PIK3R2,GNG5	
p70S6K Signaling	4.46E-01	0.22941573387056174	1.60E-01	PIK3C2B,SRC,GNAI1,PPP2R3B,HRAS,BTK,SHC1,PPP2R1A,MTOR,RRAS2,PLCE1,MAP2K2,PTPA,PRKCD,SOS1,LYN,PRKCE,PIK3R2,AGT	
Semaphorin Signaling in Neurons	4.48E-01	NaN	1.70E-01	RND2,PLXNA1,FYN,PAK4,RHOB,RHOD,DPYSL4,RHOU,NRP1	
UVB-Induced MAPK Signaling	4.48E-01	0.0	1.70E-01	FOS,PIK3C2B,MTOR,H3F3A/H3F3B,JUN,PRKCD,PRKCE,PIK3R2,EIF4EBP1	
Neuroprotective Role of THOP1 in Alzheimer's Disease	4.49E-01	NaN	1.75E-01	MME,HLA-G,SERPINA3,THOP1,HLA-F,MMP9,AGT	
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes	4.52E-01	NaN	1.65E-01	TGFBR2,FOS,FYN,IKBKG,NFKBIA,RRAS2,JUN,MAP2K2,VAV3,SOS1,HRAS,TOB1,ELK1	
Heparan Sulfate Biosynthesis	4.61E-01	NaN	1.69E-01	AADAC,B4GALT7,B3GALT6,XYLT2,HS2ST1,LIPE,EXTL3,NDST2,B3GAT3,HS3ST3A1	
PKCθ Signaling in T Lymphocytes	4.64E-01	NaN	1.61E-01	FYN,PIK3C2B,HLA-DOA,CD4,HRAS,FOS,MAP3K12,IKBKG,HLA-DRB1,NFKBIA,CAMK2D,JUN,RRAS2,VAV3,SOS1,FCER1G,CD86,MAP3K8,PIK3R2	
CREB Signaling in Neurons	4.66E-01	1.0	1.58E-01	GNA11,HRAS,SHC1,PLCE1,GNG11,CAMK2D,GNA15,MAP2K2,SOS1,PRKCE,ATF4,PIK3R2,GNG5,POLR2I,PIK3C2B,ITPR2,GNG2,GNAI1,POLR2H,GNAZ,CREB5,GNG10,POLR2G,RRAS2,PRKCD,ADCY1,ELK1	
Circadian Rhythm Signaling	4.68E-01	NaN	1.82E-01	NR1D1,BHLHE41,CLOCK,ATF4,CREB5,GRINA	
EIF2 Signaling	4.71E-01	2.3570226039551585	1.58E-01	EIF3C,RPLP1,HRAS,PPP1CB,SHC1,RPL14,MAP2K2,EIF3B,SOS1,EIF5,RPL39L,RPS2,PIK3R2,GSK3B,RPS24,EIF2AK1,PIK3C2B,RPL34,RPL7L1,RPS21,EIF2S2,RPL9,RPL8,RRAS2,RPS27L,PPP1R15A,RPL6,RPLP0,EIF3K	
CNTF Signaling	4.75E-01	1.6666666666666667	1.73E-01	PIK3C2B,MTOR,RRAS2,MAP2K2,SOS1,RPS6KB2,HRAS,RPS6KA4,PIK3R2	
PPARα/RXRα Activation	4.76E-01	1.0	1.58E-01	CD36,TGFBR3,GNA11,ADIPOQ,HRAS,IL6,AP2A2,TGFBR2,SHC1,IKBKG,NFKBIA,PLCE1,JUN,GNA15,MAP2K2,SOS1,CLOCK,GOT2,ACVR1C,IL18RAP,RRAS2,ADCY1,SLC27A1,MAP2K3,ADIPOR2,MAP4K4,MED24,CYP2C8	
IL-1 Signaling	4.76E-01	0.30151134457776363	1.65E-01	GNG2,GNA11,GNAI1,GNAZ,GNG10,IRAK1,FOS,IKBKG,NFKBIA,GNG11,JUN,GNA15,ADCY1,MAP2K3,GNG5	
DNA Double-Strand Break Repair by Homologous Recombination	4.81E-01	NaN	2.14E-01	LIG1,ABL1,RPA1	
Superpathway of Citrulline Metabolism	4.81E-01	NaN	2.14E-01	LOC102724788/PRODH,ASS1,ARG2	
Urate Biosynthesis/Inosine 5'-phosphate Degradation	4.81E-01	NaN	2.14E-01	IMPDH2,NT5C,AOX1	
γ-glutamyl Cycle	4.81E-01	NaN	2.14E-01	OPLAH,GCLM,GSS	
14-3-3-mediated Signaling	4.82E-01	0.0	1.62E-01	SRC,PIK3C2B,TUBG1,TUBB2A,HRAS,TUBB,TUBB2B,FOS,JUN,PLCE1,RRAS2,MAP2K2,PRKCD,TSC2,PRKCE,TUBA1C,GSK3B,PIK3R2,ELK1	
CCR3 Signaling in Eosinophils	4.82E-01	NaN	1.62E-01	PIK3C2B,PAK4,ITPR2,GNG2,GNAI1,PPP1CB,HRAS,MYLK,PLA2G2A,GNG10,PLA2G4A,GNG11,RRAS2,MAP2K2,PRKCD,PLA2G5,PRKCE,PIK3R2,GNG5	
IL-3 Signaling	4.86E-01	NaN	1.69E-01	FOS,PIK3C2B,SHC1,RRAS2,JUN,MAP2K2,PRKCD,SOS1,HRAS,PRKCE,PIK3R2,ELK1	
GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells	4.86E-01	NaN	1.67E-01	PLCE1,GNG11,GNA15,ITPR2,PRKCD,GPBAR1,GNA11,ADCY1,GNG2,GNAI1,LPAR5,PRKCE,GNG5,GNG10	
Citrulline Biosynthesis	4.87E-01	NaN	2.50E-01	LOC102724788/PRODH,ARG2	
Glucose and Glucose-1-phosphate Degradation	4.87E-01	NaN	2.50E-01	HK1,RGN	
Histidine Degradation III	4.87E-01	NaN	2.50E-01	MTHFD1L,MTHFD2	
Salvage Pathways of Pyrimidine Deoxyribonucleotides	4.87E-01	NaN	2.50E-01	TYMP,TK2	
NAD Salvage Pathway II	4.95E-01	NaN	1.92E-01	ACP2,ACP6,NMNAT2,NT5C,ACP5	
Cell Cycle: G1/S Checkpoint Regulation	4.99E-01	-0.6324555320336759	1.72E-01	MYC,CCND2,PA2G4,CCND3,HDAC11,ABL1,CDK4,CDKN2C,GNL3,GSK3B,CDKN2B	
Eicosanoid Signaling	4.99E-01	1.0	1.72E-01	PTGIS,PTGFR,PLA2G4A,PTGES2,AKR1C3,PLA2G5,RARRES3,PTGDS,PTGS2,PLA2G2A,PTGER4	
Type II Diabetes Mellitus Signaling	5.01E-01	-0.30151134457776363	1.64E-01	PIK3C2B,SOCS3,ACSL3,CD36,PKM,ADIPOQ,SMPD1,MTOR,IKBKG,NFKBIA,PRKCD,SOCS2,PRKCE,ACSL4,SLC27A1,IRS2,PIK3R2,ADIPOR2,NSMAF	
Amyloid Processing	5.03E-01	2.0	1.76E-01	CAPN5,CAPN6,CAPNS1,NCSTN,PRKCE,CAPN2,GSK3B,BACE2,CSNK2B	
G Protein Signaling Mediated by Tubby	5.04E-01	NaN	1.88E-01	GNG11,GNG2,ABL1,TUB,GNG5,GNG10	
Gap Junction Signaling	5.1E-01	NaN	1.61E-01	HRAS,TUBB,TUBB2B,PLCE1,MAP2K2,SOS1,CAV1,PRKCE,TUBA1C,ACTG2,PIK3R2,ACTA1,SRC,PIK3C2B,GUCY1A3,ITPR2,TUBG1,TUBB2A,GNAI1,RRAS2,LPAR1,PRKCD,ADCY1,MAPK7,MAP2K5	
RhoA Signaling	5.12E-01	1.697749375254331	1.64E-01	PLXNA1,PFN1,ARPC5L,RTKN,MYL5,ARHGAP4,PPP1CB,MYL6B,MYLK,CDC42EP2,PKN1,RHPN2,LPAR1,PIP5K1C,LPAR5,ACTG2,PI4KA,MYL3,ACTA1,KTN1	
Role of IL-17F in Allergic Inflammatory Airway Diseases	5.24E-01	-0.3779644730092272	1.82E-01	CXCL8,MAP2K2,CCL2,ATF4,IL17RC,RPS6KA4,IL6,CREB5	
Cdc42 Signaling	5.29E-01	2.5	1.62E-01	HLA-DOA,RALA,MYL5,PPP1CB,MYL6B,MYLK,CDC42EP2,CLIP1,HLA-G,ITGA3,HLA-DRB1,JUN,LLGL1,GSK3B,EXOC3,HLA-F,MYL3,SRC,PAK4,ARPC5L,TNK2,FOS,HLA-DRB4,EXOC4,WAS,ARHGEF6,FCER1G	
Prostate Cancer Signaling	5.32E-01	NaN	1.71E-01	PIK3C2B,PA2G4,SRD5A1,ABL1,HRAS,CREB5,MTOR,NFKBIA,RRAS2,MAP2K2,SOS1,ATF4,PIK3R2,GSK3B	
Human Embryonic Stem Cell Pluripotency	5.32E-01	NaN	1.64E-01	PIK3C2B,BMP4,AXIN1,FGF2,BMP2,SMAD6,SMAD7,FZD9,NGF,TGFBR2,S1PR3,NTRK3,SMO,S1PR1,FZD5,GSK3B,PIK3R2,BMP6,PDGFD,FZD2,WNT5B,FZD7	
Agrin Interactions at Neuromuscular Junction	5.36E-01	0.30151134457776363	1.74E-01	SRC,ITGA3,PAK4,RRAS2,JUN,LAMA2,ARHGEF6,HRAS,ITGA1,ERBB2,ACTG2,ACTA1	
CCR5 Signaling in Macrophages	5.36E-01	NaN	1.74E-01	FOS,JUN,GNG11,CD4,PRKCD,GNG2,FCER1G,GNAI1,PRKCE,GNG5,CCL3,GNG10	
Assembly of RNA Polymerase III Complex	5.41E-01	NaN	2.31E-01	GTF3C1,GTF3A,BRF2	
Bile Acid Biosynthesis, Neutral Pathway	5.41E-01	NaN	2.31E-01	CYP27A1,AKR1C3,AKR1C4	
Fatty Acid Activation	5.41E-01	NaN	2.31E-01	ACSL3,ACSL4,SLC27A1	
Actin Nucleation by ARP-WASP Complex	5.43E-01	1.8973665961010275	1.79E-01	RND2,ITGA3,RRAS2,RHOB,WAS,RHOD,ARPC5L,SOS1,RHOU,HRAS	
IL-4 Signaling	5.47E-01	NaN	1.73E-01	PIK3C2B,HLA-DOA,HRAS,INPPL1,HMGA1,SHC1,MTOR,HLA-DRB1,RRAS2,SOS1,RPS6KB2,PIK3R2,FCER2	
Cardiac β-adrenergic Signaling	5.51E-01	-1.5	1.65E-01	AKAP12,ADRBK1,PPP1R1A,PPP1R3C,GNG2,PPP1CB,PPP2R3B,PPP1R14A,PPP1R11,ATP2A2,PPP1R14B,MPPE1,GNG10,PPP2R1A,GNG11,PTPA,PDE3B,PDE1B,ADCY1,PDE8B,PKIA,GNG5	
Aspartate Degradation II	5.71E-01	NaN	2.86E-01	GOT1,GOT2	
Pregnenolone Biosynthesis	5.71E-01	NaN	2.86E-01	CYP11A1,CYP4F11	
Superpathway of Serine and Glycine Biosynthesis I	5.71E-01	NaN	2.86E-01	PSAT1,SHMT2	
Adenine and Adenosine Salvage I	5.71E-01	NaN	5.00E-01	APRT,	
Anandamide Degradation	5.71E-01	NaN	5.00E-01	FAAH,	
Cardiolipin Biosynthesis II	5.71E-01	NaN	5.00E-01	PTPMT1,	
Choline Degradation I	5.71E-01	NaN	5.00E-01	CHDH,	
Cysteine Biosynthesis/Homocysteine Degradation	5.71E-01	NaN	5.00E-01	CBS/CBSL,	
Epoxysqualene Biosynthesis	5.71E-01	NaN	5.00E-01	SQLE,	
Flavin Biosynthesis IV (Mammalian)	5.71E-01	NaN	5.00E-01	FLAD1,	
GDP-L-fucose Biosynthesis II (from L-fucose)	5.71E-01	NaN	5.00E-01	FUK,	
Glycine Biosynthesis I	5.71E-01	NaN	5.00E-01	SHMT2,	
Glycine Degradation (Creatine Biosynthesis)	5.71E-01	NaN	5.00E-01	GAMT,	
L-DOPA Degradation	5.71E-01	NaN	5.00E-01	COMT,	
L-cysteine Degradation III	5.71E-01	NaN	5.00E-01	GOT1,	
Putrescine Biosynthesis III	5.71E-01	NaN	5.00E-01	ODC1,	
Spermidine Biosynthesis I	5.71E-01	NaN	5.00E-01	SRM,	
Threonine Degradation II	5.71E-01	NaN	5.00E-01	GCAT,	
Synaptic Long Term Potentiation	5.71E-01	0.8944271909999159	1.68E-01	PPP1R1A,ITPR2,PPP1R3C,GNA11,PPP1CB,HRAS,PPP1R14A,PPP1R11,CREB5,PPP1R14B,GRINA,CAMK2D,PLCE1,RRAS2,GNA15,MAP2K2,PRKCD,ADCY1,PRKCE,ATF4	
FLT3 Signaling in Hematopoietic Progenitor Cells	5.73E-01	1.7320508075688774	1.76E-01	PIK3C2B,HRAS,CREB5,EIF4EBP1,SHC1,MTOR,RRAS2,MAP2K2,SOS1,ATF4,RPS6KA4,PIK3R2,ELK1	
Retinoic acid Mediated Apoptosis Signaling	5.82E-01	1.6666666666666667	1.80E-01	PARP6,TIPARP,PARP10,RARA,TNFRSF10B,PARP2,DAP3,TNFSF10,PARP3,CRABP2,CRABP1	
Pyrimidine Ribonucleotides De Novo Biosynthesis	5.84E-01	NaN	2.00E-01	NME1,AK1,ENTPD6,AK4,CTPS1,DDX3X	
Antioxidant Action of Vitamin C	5.86E-01	-1.2649110640673518	1.72E-01	SLC2A5,PLD3,GLRX,PLA2G2A,SLC2A3,TXNRD1,HMOX1,PLA2G4A,IKBKG,NFKBIA,PLCE1,CSF2RA,PLA2G5,RARRES3,TXN,GSTO2,TXNRD2	
Telomerase Signaling	5.86E-01	-0.7745966692414834	1.72E-01	ETS1,PIK3C2B,DKC1,ABL1,PPP2R3B,HRAS,MYC,SHC1,PPP2R1A,RRAS2,MAP2K2,PTPA,ETS2,HDAC11,SOS1,TPP1,PIK3R2	
Phosphatidylglycerol Biosynthesis II (Non-plastidic)	5.9E-01	NaN	2.22E-01	GPAM,ABHD5,LCLAT1,PTPMT1	
Factors Promoting Cardiogenesis in Vertebrates	6.01E-01	NaN	1.74E-01	NOX4,BMP4,AXIN1,TGFBR3,BMP2,FZD9,TGFBR2,PRKCD,SMO,PRKCE,FZD5,GSK3B,BMP6,FZD2,ACVR1C,FZD7	
Salvage Pathways of Pyrimidine Ribonucleotides	6.01E-01	NaN	1.74E-01	NME1,FAM20B,SGK1,UPP1,CDK4,GRK5,PKN1,IRAK1,AK1,MAP2K2,PRKCD,AK4,PRKCE,MAP3K8,MAP2K3,MAPK7	
Androgen Signaling	6.05E-01	0.0	1.71E-01	POLR2I,SRC,GNA11,GNG2,GNAI1,POLR2H,GNAZ,ERCC2,GNG10,POLR2G,SHC1,HSPA4,KAT2B,GNG11,JUN,GNA15,PRKCD,PRKCE,GNG5	
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency	6.05E-01	-1.6666666666666667	1.71E-01	PIK3C2B,BMP4,AXIN1,BMP2,HRAS,FZD9,SHC1,RRAS2,MAP2K2,SOS1,SMO,FZD5,GSK3B,PIK3R2,BMP6,FZD2,WNT5B,ZFP42,FZD7	
Role of IL-17A in Arthritis	6.06E-01	NaN	1.85E-01	PIK3C2B,CXCL8,NFKBIA,MAP2K2,CCL2,IL17RC,MAP2K3,PTGS2,PIK3R2,MAPKAPK2	
Protein Kinase A Signaling	6.12E-01	-1.8203641092364127	1.58E-01	PTPN23,MYL5,LIPE,MYL6B,PPP1R14B,TGFBR2,CAMK2D,PLCE1,GYS1,MAP2K2,ATF4,PGP,GSK3B,CDC16,EYA2,MYL3,PHKG1,PTPRE,PPP1R1B,ITPR2,GNG2,PPP1R14A,PPP1R11,PTPN3,CREB5,GNG10,H3F3A/H3F3B,DUSP1,PTPRB,PRKCD,PDE1B,H1F0,PTPRA,AKAP12,HIST1H1C,PPP1R3C,PPP1CB,UBASH3B,DUSP22,MYLK,PTPRF,MPPE1,DUSP5,NFKBIA,GNG11,FLNA,PDE3B,DUSP10,SMO,PRKCE,GNG5,PTPRT,PTPRK,GNAI1,PYGB,FLNC,ADCY1,KDELR3,PDE8B,PTGS2,ELK1	
ErbB4 Signaling	6.13E-01	1.2649110640673518	1.83E-01	PIK3C2B,SHC1,ADAM17,RRAS2,MAP2K2,PRKCD,SOS1,HRAS,NCSTN,PRKCE,PIK3R2	
p38 MAPK Signaling	6.14E-01	0.6882472016116852	1.71E-01	DDIT3,MKNK2,CREB5,PLA2G2A,IRAK1,IL18RAP,MYC,TGFBR2,PLA2G4A,H3F3A/H3F3B,DUSP1,DUSP10,PLA2G5,RPS6KB2,ATF4,MAP2K3,RPS6KA4,HSPB7,ELK1,MAPKAPK2	
Cell Cycle Regulation by BTG Family Proteins	6.29E-01	NaN	2.00E-01	PPP2R1A,PTPA,BTG2,BTG1,CDK4,PPP2R3B,PRMT1	
Triacylglycerol Biosynthesis	6.29E-01	NaN	2.00E-01	GPAM,ABHD5,LCLAT1,LPIN1,DGAT2,LPIN2,ELOVL6	
tRNA Splicing	6.29E-01	NaN	2.00E-01	TSEN15,PDE3B,TSEN54,PDE1B,TRPT1,PDE8B,MPPE1	
Glutathione-mediated Detoxification	6.29E-01	NaN	2.07E-01	GSTM1,GSTM2,GSTM5,GSTM3,GSTO2,GSTT1	
TNFR2 Signaling	6.29E-01	-0.4472135954999579	2.07E-01	FOS,IKBKG,NFKBIA,JUN,TNFAIP3,BIRC3	
eNOS Signaling	6.29E-01	-1.5275252316519468	1.69E-01	PIK3C2B,GUCY1A3,ITPR2,HSPA1A/HSPA1B,HSPA9,SLC7A1,VEGFC,HSPA5,HSPA2,HSPA8,HSPA4,AQP9,NOSIP,LPAR1,STUB1,PRKCD,ADCY1,LPAR5,CAV1,VEGFD,PRKCE,PIK3R2,KDR,ESR1	
FcγRIIB Signaling in B Lymphocytes	6.31E-01	0.7071067811865475	1.95E-01	BTK,PIK3C2B,SHC1,RRAS2,SOS1,LYN,HRAS,PIK3R2	
nNOS Signaling in Neurons	6.34E-01	NaN	1.91E-01	CAPN5,CAPN6,CAPNS1,PRKCD,DLG4,PRKCE,CAPN2,RASD1,GRINA	
T Cell Receptor Signaling	6.34E-01	NaN	1.75E-01	FYN,PIK3C2B,CD4,CSK,HRAS,BTK,FOS,IKBKG,NFKBIA,JUN,RRAS2,MAP2K2,PAG1,VAV3,SOS1,PIK3R2,ELK1	
Melanocyte Development and Pigmentation Signaling	6.44E-01	2.32379000772445	1.79E-01	SRC,PIK3C2B,HRAS,POMC,CREB5,SHC1,RRAS2,MAP2K2,ADCY1,SOS1,RPS6KB2,KIT,ATF4,RPS6KA4,PIK3R2	
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis	6.44E-01	NaN	1.64E-01	ADAM17,BMP4,SFRP2,FRZB,AXIN1,BMP2,ACP5,IL6,IKBKG,ITGA3,NFKBIA,JUN,DKK3,SMO,GSK3B,PIK3R2,FZD2,BIRC3,ALPL,WNT5B,SFRP4,SRC,PIK3C2B,CTSK,SPP1,SMAD6,FZD9,CSF1R,IL18RAP,FOS,COL1A1,MAP2K3,FZD5,SFRP1,BMP6,FZD7	
ATM Signaling	6.45E-01	0.8164965809277261	1.86E-01	NFKBIA,GADD45B,JUN,GADD45A,TRIM28,ABL1,ATF4,TP53BP1,CREB5,CBX5,CHEK2	
Dermatan Sulfate Degradation (Metazoa)	6.5E-01	NaN	2.35E-01	IDUA,GM2A,HYAL1,HEXA	
γ-linolenate Biosynthesis II (Animals)	6.5E-01	NaN	2.35E-01	ACSL3,ACSL4,SLC27A1,CYB5A	
Non-Small Cell Lung Cancer Signaling	6.51E-01	0.7071067811865475	1.85E-01	PIK3C2B,RRAS2,PA2G4,MAP2K2,ITPR2,SOS1,ABL1,CDK4,HRAS,ERBB2,PIK3R2,RASSF5	
Renal Cell Carcinoma Signaling	6.57E-01	0.0	1.83E-01	ETS1,FOS,PIK3C2B,PAK4,RRAS2,JUN,MAP2K2,SOS1,HRAS,PIK3R2,HIF1A,TCEB2,VHL	
Thyroid Cancer Signaling	6.71E-01	NaN	2.00E-01	MYC,SHC1,RRAS2,MAP2K2,NTRK3,HRAS,RET,NGF	
CD27 Signaling in Lymphocytes	6.74E-01	1.414213562373095	1.92E-01	FOS,BCL2L1,MAP3K12,IKBKG,NFKBIA,JUN,MAP2K2,MAP2K3,MAP3K8,MAP2K5	
GDP-mannose Biosynthesis	6.76E-01	NaN	3.33E-01	GMPPB,GMPPA	
Pentose Phosphate Pathway (Non-oxidative Branch)	6.76E-01	NaN	3.33E-01	RPE,TALDO1	
Urea Cycle	6.76E-01	NaN	3.33E-01	ASS1,ARG2	
Pyrimidine Ribonucleotides Interconversion	6.78E-01	NaN	2.14E-01	NME1,AK1,ENTPD6,AK4,CTPS1,DDX3X	
Apoptosis Signaling	6.78E-01	0.2581988897471611	1.80E-01	CAPN5,CAPN6,HRAS,LMNA,DIABLO,BCL2L1,IKBKG,NFKBIA,RRAS2,CAPNS1,MAP2K2,PRKCE,CAPN2,BIRC3,MAP4K4,MCL1	
Crosstalk between Dendritic Cells and Natural Killer Cells	6.78E-01	NaN	1.80E-01	CD209,TYROBP,CD69,TNFSF10,IL6,HLA-G,HLA-DRB1,CAMK2D,TLN2,HLA-DRB4,FSCN1,CD86,LTBR,ACTG2,HLA-F,ACTA1	
PAK Signaling	6.78E-01	2.0	1.80E-01	PIK3C2B,PAK4,MYL5,HRAS,MYL6B,MYLK,SHC1,ITGA3,RRAS2,MAP2K2,ARHGEF6,SOS1,EPHB3,PIK3R2,PDGFD,MYL3	
Glycogen Degradation II	6.88E-01	NaN	2.73E-01	TYMP,PYGB,AGL	
NGF Signaling	7E-01	2.0647416048350555	1.78E-01	PIK3C2B,HRAS,SMPD1,CREB5,NGF,SHC1,MAP3K12,IKBKG,RRAS2,MAP2K2,PRKCD,SOS1,RPS6KB2,ATF4,RPS6KA4,MAP3K8,MAPK7,PIK3R2,ELK1	
Glutamate Receptor Signaling	7.13E-01	NaN	1.93E-01	HOMER2,SLC1A4,GNG11,GNG2,SLC1A3,DLG4,GLUL,SLC38A1,HOMER3,GNG5,GRINA	
Antiproliferative Role of Somatostatin Receptor 2	7.16E-01	1.8973665961010275	1.90E-01	PIK3C2B,SRC,RRAS2,GNG11,GUCY1A3,MAP2K2,GNG2,HRAS,PIK3R2,GNG5,ELK1,GNG10	
RAN Signaling	7.18E-01	NaN	2.50E-01	CSE1L,RANGAP1,RAN,KPNA2	
TGF-β Signaling	7.35E-01	0.2773500981126146	1.84E-01	BMP4,BMP2,SMAD6,SMAD7,HRAS,INHBB,TGFBR2,FOS,JUN,RRAS2,MAP2K2,SOS1,MAP2K3,ACVR1C,AMHR2,PMEPA1	
PTEN Signaling	7.4E-01	-1.3416407864998738	1.78E-01	MAST2,SHARPIN,TGFBR3,HRAS,INPPL1,IGF2R,TGFBR2,SHC1,BCL2L1,ITGA3,IKBKG,RRAS2,MAP2K2,NTRK3,SOS1,RPS6KB2,GSK3B,CSNK2B,PIK3R2,KDR,MCRS1	
Endoplasmic Reticulum Stress Pathway	7.51E-01	NaN	2.38E-01	DDIT3,ERN1,ATF4,ATF6,HSPA5	
iNOS Signaling	7.52E-01	NaN	2.05E-01	FOS,IKBKG,LY96,NFKBIA,JUN,CD14,LBP,HMGA1,IRAK1	
HGF Signaling	7.53E-01	0.0	1.81E-01	ETS1,PIK3C2B,HRAS,IL6,FOS,DOCK1,MAP3K12,ITGA3,JUN,RRAS2,MAP2K2,ETS2,PRKCD,SOS1,PRKCE,MAP3K8,PIK3R2,PTGS2,ELK1	
Macropinocytosis Signaling	7.53E-01	1.6666666666666667	1.91E-01	PIK3C2B,SRC,RAB5A,RRAS2,PRKCD,HRAS,CD14,PRKCE,PIK3R2,NGF,PDGFD,RAB34,CSF1R	
Gα12/13 Signaling	7.65E-01	2.23606797749979	1.79E-01	PIK3C2B,SRC,MYL5,HRAS,MYL6B,BTK,CDH2,IKBKG,NFKBIA,RRAS2,CDH12,JUN,CDH5,LPAR1,MAP2K2,VAV3,LPAR5,MAPK7,PIK3R2,ELK1,MYL3	
Death Receptor Signaling	7.69E-01	2.182820625326997	1.85E-01	TNFRSF21,PARP6,PARP10,TNFRSF10B,PARP2,TNFSF10,LMNA,PARP3,DIABLO,IKBKG,NFKBIA,TIPARP,HSPB7,ACTG2,BIRC3,MAP4K4,ACTA1	
VEGF Signaling	7.69E-01	0.5	1.85E-01	SRC,PIK3C2B,HRAS,VEGFC,HIF1A,EIF2S2,SHC1,BCL2L1,RRAS2,MAP2K2,SOS1,VEGFD,PIK3R2,ACTG2,KDR,ACTA1,ACTN1	
G-Protein Coupled Receptor Signaling	7.87E-01	NaN	1.68E-01	FYN,HCAR3,ADRBK1,GNA11,LHCGR,HRAS,RGS12,MPPE1,SHC1,IKBKG,NFKBIA,CAMK2D,GNA15,MAP2K2,PDE3B,SOS1,ATF4,PRKCE,PIK3R2,ADORA1,HCAR2,PTGER4,ADRA1B,ADRB2,PIK3C2B,SRC,APLNR,RGS16,GNAI1,CREB5,S1PR3,RRAS2,ADRA2A,NPR3,LPAR1,RAP1GAP,DUSP1,PDE1B,ADCY1,S1PR1,MAP3K8,PDE8B,ADRA1A	
STAT3 Pathway	7.89E-01	0.5345224838248488	1.92E-01	SOCS3,SRC,TGFBR3,HRAS,IGF2R,NDUFA13,TGFBR2,MYC,MAP3K12,RRAS2,MAP2K2,NTRK3,SOCS2,KDR	
NAD biosynthesis II (from tryptophan)	7.93E-01	NaN	2.67E-01	ABL1,IDO1,QPRT,NMNAT2	
The Visual Cycle	7.93E-01	NaN	2.67E-01	DHRS3,DHRS9,RDH5,RBP5	
Colorectal Cancer Metastasis Signaling	8E-01	0.9733285267845753	1.69E-01	ADRBK1,AXIN1,HRAS,IL6,MMP25,MYC,TGFBR2,JUN,GNG11,RHOB,MAP2K2,RHOD,SOS1,SMO,RHOU,VEGFD,GSK3B,PIK3R2,GNG5,FZD2,WNT5B,PTGER4,RND2,SRC,PIK3C2B,MMP28,GNG2,VEGFC,FZD9,MMP2,GNG10,FOS,BCL2L1,RRAS2,MMP23B,ADCY1,FZD5,PTGS2,MMP9,FZD7	
Cardiac Hypertrophy Signaling	8.03E-01	2.0	1.70E-01	GNA11,MYL5,HRAS,MYL6B,ATF6,IL6,TGFBR2,MTOR,PLCE1,JUN,GNG11,GNA15,RHOB,MAP2K2,RHOD,SOS1,RHOU,GSK3B,PIK3R2,GNG5,MAPKAPK2,MYL3,ADRA1B,ADRB2,RND2,PIK3C2B,GNG2,GNAI1,GNAZ,GNG10,MAP3K12,RRAS2,ADRA2A,ADCY1,MAP2K3,MAP3K8,ELK1,ADRA1A	
Estrogen Receptor Signaling	8.04E-01	NaN	1.80E-01	POLR2I,SRC,TAF6,MED20,MED30,POLR2H,HRAS,TAF10,ERCC2,G6PC3,TAF9B,POLR2G,SHC1,KAT2B,RRAS2,H3F3A/H3F3B,PCK2,MAP2K2,SOS1,MED16,ESR1,MED24,CARM1	
Antigen Presentation Pathway	8.06E-01	NaN	2.16E-01	HLA-G,HLA-DOA,HLA-DRB1,PSMB5,HLA-DRB4,CANX,PSMB6,HLA-F	
2-oxobutanoate Degradation I	8.1E-01	NaN	4.00E-01	MCEE,PCCB	
Eumelanin Biosynthesis	8.1E-01	NaN	4.00E-01	MIF,DDT	
Folate Polyglutamylation	8.1E-01	NaN	4.00E-01	MTHFD1L,SHMT2	
Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate	8.1E-01	NaN	4.00E-01	MTHFD1L,MTHFD2	
Actin Cytoskeleton Signaling	8.15E-01	2.334868926348074	1.71E-01	PFN1,FGF2,MYL5,PPP1CB,HRAS,MYL6B,MYLK,MYH11,SLC9A1,SHC1,ITGA3,MAP2K2,FLNA,SOS1,LBP,PIK3R2,ACTG2,ACTN1,MYL3,ACTA1,MATK,MYH1,PIK3C2B,ARHGEF4,PAK4,ARPC5L,CSK,DOCK1,RRAS2,TLN2,WAS,PIP5K1C,VAV3,ARHGEF6,CD14,PDGFD,NCKAP1L	
Angiopoietin Signaling	8.23E-01	0.6324555320336759	1.97E-01	PIK3C2B,PAK4,GRB14,ANGPT1,DOK2,HRAS,IKBKG,TNIP1,NFKBIA,RRAS2,SOS1,PIK3R2,TEK	
JAK/Stat Signaling	8.24E-01	1.0690449676496976	1.94E-01	SOCS3,PIK3C2B,HRAS,IL6,SHC1,BCL2L1,FOS,MTOR,JUN,RRAS2,MAP2K2,SOS1,SOCS2,PIK3R2	
Dopamine Receptor Signaling	8.25E-01	-0.3779644730092272	1.92E-01	PPP1R1B,PPP1R3C,PPP1CB,PPP2R3B,PPP1R14A,PPP1R11,PPP1R14B,PPP2R1A,SMOX,PTPA,COMT,PTS,ADCY1,PCBD1,MAOA	
PI3K Signaling in B Lymphocytes	8.29E-01	-1.091089451179962	1.81E-01	FYN,ATF3,ATF5,ITPR2,ABL1,HRAS,ATF6,BTK,FOS,IKBKG,NFKBIA,CAMK2D,RRAS2,JUN,PLCE1,MAP2K2,VAV3,LYN,ATF4,IRS2,PLEKHA2,PIK3R2,ELK1	
Acetyl-CoA Biosynthesis III (from Citrate)	8.4E-01	NaN	1.00E00	ACLY,	
Asparagine Biosynthesis I	8.4E-01	NaN	1.00E00	ASNS,	
Glutamine Biosynthesis I	8.4E-01	NaN	1.00E00	GLUL,	
Histamine Biosynthesis	8.4E-01	NaN	1.00E00	HDC,	
Lanosterol Biosynthesis	8.4E-01	NaN	1.00E00	LSS,	
Methylglyoxal Degradation VI	8.4E-01	NaN	1.00E00	LDHD,	
Phosphatidylethanolamine Biosynthesis III	8.4E-01	NaN	1.00E00	PTDSS2,	
Sorbitol Degradation I	8.4E-01	NaN	1.00E00	SORD,	
Thio-molybdenum Cofactor Biosynthesis	8.4E-01	NaN	1.00E00	MOCOS,	
UDP-N-acetyl-D-galactosamine Biosynthesis I	8.4E-01	NaN	1.00E00	GALE,	
Fc Epsilon RI Signaling	8.41E-01	1.3416407864998738	1.85E-01	FYN,PIK3C2B,FCER1A,HRAS,INPPL1,PLA2G2A,BTK,PLA2G4A,RRAS2,MAP2K2,PRKCD,VAV3,PLA2G5,SOS1,LYN,FCER1G,MS4A2,PRKCE,MAP2K3,PIK3R2	
fMLP Signaling in Neutrophils	8.41E-01	1.4142135623730951	1.85E-01	FPR3,PIK3C2B,NOX4,ARPC5L,ITPR2,GNG2,GNAI1,HRAS,GNG10,NFKBIA,RRAS2,GNG11,MAP2K2,WAS,PRKCD,NCF2,PRKCE,PIK3R2,GNG5,ELK1	
UVC-Induced MAPK Signaling	8.42E-01	1.0	2.14E-01	FOS,SRC,RRAS2,JUN,MAP2K2,PRKCD,HRAS,PRKCE,SMPD1	
Bupropion Degradation	8.47E-01	NaN	2.40E-01	POR,CYP4B1,CYP4X1,CYP1B1,CYP51A1,CYP2C8	
Chemokine Signaling	8.59E-01	1.0690449676496976	1.97E-01	SRC,CAMK1,CXCR4,CXCL12,GNAI1,PPP1CB,HRAS,FOS,CAMK2D,JUN,CCL13,RRAS2,CCL2,MAP2K2	
CD40 Signaling	8.61E-01	1.1547005383792517	2.00E-01	PIK3C2B,TNFAIP3,FOS,IKBKG,NFKBIA,JUN,MAP2K2,MAP2K3,PIK3R2,PTGS2,MAPKAPK2,MAP2K5,FCER2	
IL-2 Signaling	8.69E-01	1.0	2.08E-01	FOS,PIK3C2B,SHC1,RRAS2,JUN,MAP2K2,SOS1,HRAS,PIK3R2,CSNK2B,ELK1	
Androgen Biosynthesis	8.78E-01	NaN	2.86E-01	AKR1C3,SRD5A1,AKR1C4,HSD17B14	
Isoleucine Degradation I	8.78E-01	NaN	2.86E-01	ACAT2,BCAT2,ACAT1,HADHA	
Ubiquinol-10 Biosynthesis (Eukaryotic)	8.78E-01	NaN	2.86E-01	CYP11A1,COQ2,CYP4F11,ECHDC1	
Folate Transformations I	8.88E-01	NaN	3.33E-01	MTHFD1L,MTHFD2,SHMT2	
Ketolysis	8.88E-01	NaN	3.33E-01	ACAT2,ACAT1,HADHA	
Sucrose Degradation V (Mammalian)	8.88E-01	NaN	3.33E-01	ALDOA,GALM,ALDOC	
UDP-N-acetyl-D-galactosamine Biosynthesis II	8.88E-01	NaN	3.33E-01	HK1,GNPDA1,GALE	
GADD45 Signaling	8.91E-01	NaN	2.63E-01	GADD45B,CCND2,CCND3,GADD45A,CDK4	
Glutathione Redox Reactions I	8.91E-01	NaN	2.63E-01	GSR,GPX3,GPX8,GPX7,GSTT1	
UVA-Induced MAPK Signaling	8.94E-01	1.386750490563073	1.93E-01	PARP6,PIK3C2B,PARP10,PARP2,HRAS,SMPD1,PARP3,FOS,BCL2L1,MTOR,JUN,PLCE1,RRAS2,TIPARP,RPS6KB2,RPS6KA4,PIK3R2	
Pyridoxal 5'-phosphate Salvage Pathway	9E-01	NaN	2.03E-01	FAM20B,PNPO,MAP2K2,SGK1,PRKCD,CDK4,PRKCE,MAP2K3,MAP3K8,GRK5,MAPK7,PKN1,IRAK1	
Pancreatic Adenocarcinoma Signaling	9E-01	0.5	1.89E-01	PIK3C2B,RALA,PLD3,PA2G4,ABL1,CDK4,VEGFC,HBEGF,CDKN2B,TGFBR2,HMOX1,BCL2L1,MAP2K2,VEGFD,ERBB2,PIK3R2,PTGS2,ELK1,NOTCH1,MMP9	
Endometrial Cancer Signaling	9.13E-01	NaN	2.12E-01	MYC,PIK3C2B,RRAS2,MAP2K2,AXIN1,SOS1,HRAS,GSK3B,ERBB2,PIK3R2,ELK1	
α-Adrenergic Signaling	9.28E-01	0.5773502691896258	1.95E-01	ITPR2,GNG2,GNAI1,HRAS,PYGB,GNG10,GNG11,GYS1,RRAS2,ADRA2A,MAP2K2,PRKCD,ADCY1,PRKCE,GNG5,ADRA1A,PHKG1	
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes	9.28E-01	0.9428090415820635	1.94E-01	SRC,FYN,PLD3,ARPC5L,MYO5A,DOCK1,HMOX1,TLN2,WAS,VAV3,PRKCD,LYN,RPS6KB2,PRKCE,ACTG2,PIK3R2,ACTA1,FCGR3A/FCGR3B	
CDK5 Signaling	9.29E-01	0.9428090415820635	1.92E-01	PPP1R1B,PPP1R3C,EGR1,ABL1,PPP1CB,PPP2R3B,HRAS,PPP1R14A,PPP1R11,NGF,PPP1R14B,FOSB,ITGA3,PPP2R1A,RRAS2,MAP2K2,PTPA,ADCY1,MAPK7	
Nicotine Degradation II	9.4E-01	NaN	2.06E-01	FMO3,FMO2,CYP1B1,POR,LARGE1,CYP4B1,CYP4X1,FMO1,B3GAT3,AOX1,FMO4,CYP51A1,CYP2C8	
ErbB2-ErbB3 Signaling	9.48E-01	NaN	2.11E-01	MYC,PIK3C2B,SHC1,RRAS2,JUN,MAP2K2,SOS1,HRAS,GSK3B,ERBB2,PIK3R2,ELK1	
Regulation of Cellular Mechanics by Calpain Protease	9.48E-01	3.0	2.11E-01	CAPN5,SRC,ITGA3,CAPN6,CAPNS1,RRAS2,TLN2,CDK4,HRAS,CAPN2,CAST,ACTN1	
Endothelin-1 Signaling	9.49E-01	-0.18569533817705186	1.80E-01	GNA11,HRAS,CASP4,MYC,HMOX1,SHC1,PLCE1,JUN,GNA15,EDN1,PLA2G5,SOS1,PRKCE,PIK3R2,SRC,PIK3C2B,PLD3,GUCY1A3,ITPR2,GNAI1,GNAZ,PLA2G2A,PLA2G4A,FOS,RRAS2,PRKCD,ADCY1,EDNRA,RARRES3,PTGS2,MAPK7	
AMPK Signaling	9.55E-01	-1.5689290811054724	1.80E-01	LEP,PFKFB1,ADIPOQ,PPP2R3B,LIPE,PFKL,EIF4EBP1,MTOR,AK1,GYS1,KAT2B,PCK2,TSC2,SMARCB1,ATF4,IRS2,PIK3R2,ADRA1B,ADRB2,PFKFB3,SRC,PIK3C2B,CREB5,MLST8,PPP2R1A,ADRA2A,PTPA,AK4,MAP2K3,ACACA,AK2,ADRA1A	
Regulation of the Epithelial-Mesenchymal Transition Pathway	9.6E-01	NaN	1.79E-01	LOX,ADAM17,AXIN1,FGF2,HRAS,NCSTN,HIF1A,TGFBR2,MAP2K2,SOS1,SMO,GSK3B,PIK3R2,FZD2,WNT5B,ETS1,PIK3C2B,EGR1,FZD9,MMP2,PYGO2,DVL2,CDH2,CDH12,RRAS2,DVL3,MAP2K3,FZD5,PDGFD,NOTCH1,MMP9,MAP2K5,FZD7	
Role of Tissue Factor in Cancer	9.64E-01	NaN	1.91E-01	PIK3C2B,CXCL8,FYN,SRC,CTGF,EGR1,GNA11,HRAS,PLAUR,VEGFC,HBEGF,BCL2L1,ITGA3,MTOR,RRAS2,GNA15,PDXP,LYN,RPS6KA4,PIK3R2,CYR61	
Ceramide Signaling	9.65E-01	1.0690449676496976	2.00E-01	PIK3C2B,SPHK2,PPP2R3B,HRAS,SMPD1,DIABLO,S1PR3,CTSD,FOS,PPP2R1A,JUN,RRAS2,PTPA,S1PR1,PIK3R2,NSMAF	
Inhibition of Angiogenesis by TSP1	9.67E-01	-1.6329931618554523	2.35E-01	TGFBR2,FYN,JUN,GUCY1A3,THBS1,CD36,KDR,MMP9	
Oncostatin M Signaling	9.67E-01	1.1338934190276817	2.35E-01	MT2A,SHC1,RRAS2,EPAS1,MAP2K2,SOS1,HRAS,ELK1	
Glycogen Degradation III	9.74E-01	NaN	3.08E-01	GAA,TYMP,PYGB,AGL	
NAD Phosphorylation and Dephosphorylation	9.74E-01	NaN	3.08E-01	ACP2,NADK2,ACP6,ACP5	
Role of IL-17A in Psoriasis	9.74E-01	NaN	3.08E-01	CXCL8,S100A9,IL17RC,S100A8	
Epithelial Adherens Junction Signaling	9.82E-01	NaN	1.85E-01	TGFBR3,MYL5,HRAS,MYL6B,MYH11,TUBB,CLIP1,TUBB2B,TGFBR2,SORBS1,KEAP1,TUBA1C,ACTG2,ACVR1C,MYL3,ACTA1,ACTN1,MYH1,SRC,EPN1,ARPC5L,TUBG1,TUBB2A,CDH2,RRAS2,WAS,NOTCH1	
Arginine Degradation I (Arginase Pathway)	9.89E-01	NaN	5.00E-01	ALDH4A1,ARG2	
Arsenate Detoxification I (Glutaredoxin)	9.89E-01	NaN	5.00E-01	GLRX2,AS3MT	
Ascorbate Recycling (Cytosolic)	9.89E-01	NaN	5.00E-01	GSTO2,GLRX	
Heme Biosynthesis from Uroporphyrinogen-III I	9.89E-01	NaN	5.00E-01	PPOX,FECH	
Melatonin Degradation II	9.89E-01	NaN	5.00E-01	SMOX,MAOA	
Methylmalonyl Pathway	9.89E-01	NaN	5.00E-01	MCEE,PCCB	
Proline Biosynthesis I	9.89E-01	NaN	5.00E-01	PYCR2,PYCR1	
EGF Signaling	9.93E-01	0.5773502691896258	2.14E-01	FOS,PIK3C2B,SRC,SHC1,MTOR,JUN,ITPR2,SOS1,HRAS,PIK3R2,CSNK2B,ELK1	
Inhibition of Matrix Metalloproteases	9.97E-01	NaN	2.31E-01	TIMP4,ADAM17,MMP23B,MMP28,TIMP1,MMP2,MMP25,TFPI2,MMP9	
LPS-stimulated MAPK Signaling	1.01E00	1.0690449676496976	2.05E-01	PIK3C2B,HRAS,FOS,IKBKG,NFKBIA,JUN,RRAS2,MAP2K2,PRKCD,PRKCE,CD14,MAP2K3,LBP,PIK3R2,ELK1	
Prolactin Signaling	1.01E00	0.7745966692414834	2.05E-01	FYN,SOCS3,PIK3C2B,HRAS,MYC,SHC1,FOS,JUN,RRAS2,MAP2K2,PRKCD,SOS1,SOCS2,PRKCE,PIK3R2	
Airway Pathology in Chronic Obstructive Pulmonary Disease	1.02E00	NaN	3.75E-01	CXCL8,MMP2,MMP9	
MIF-mediated Glucocorticoid Regulation	1.03E00	1.1338934190276817	2.42E-01	PLA2G4A,MIF,LY96,NFKBIA,PLA2G5,CD14,PTGS2,PLA2G2A	
Gαi Signaling	1.03E00	-1.7056057308448833	1.92E-01	SRC,RALA,APLNR,GNG2,GNAI1,HRAS,RGS12,GNG10,S1PR3,SHC1,RRAS2,GNG11,ADRA2A,NPR3,LPAR1,RAP1GAP,ADCY1,SOS1,S1PR1,CAV1,GNG5,ADORA1,HCAR2	
HMGB1 Signaling	1.03E00	0.6255432421712244	1.92E-01	RND2,CXCL8,PIK3C2B,VCAM1,SELE,HRAS,IL6,FOS,JUN,RRAS2,KAT2B,RHOB,CCL2,MAP2K2,RHOD,IL17D,RHOU,MAP2K3,PIK3R2,ELK1,KAT2A,MAP2K5,PLAT	
Glucocorticoid Receptor Signaling	1.03E00	NaN	1.75E-01	SGK1,HSPA1A/HSPA1B,HRAS,POMC,IL6,TAF10,HSPA5,CCL3,CD163,TGFBR2,SHC1,HSPA4,IKBKG,NFKBIA,KAT2B,JUN,CCL13,CCL2,PCK2,MAP2K2,SMARCB1,SOS1,PIK3R2,ADRB2,AGT,POLR2I,PIK3C2B,CXCL8,VCAM1,SELE,CDKN1C,TAF6,HSPA9,POLR2H,ERCC2,HSPA2,TAF9B,HSPA8,POLR2G,FOS,BCL2L1,RRAS2,DUSP1,FKBP4,PTGS2,ELK1,ESR1,UBE2I	
mTOR Signaling	1.04E00	2.2	1.82E-01	EIF3C,PPP2R3B,HRAS,FKBP1A,HIF1A,EIF4EBP1,HMOX1,MTOR,RHOB,EIF3B,RHOD,TSC2,RHOU,RPS6KB2,VEGFD,PRKCE,RPS2,PIK3R2,RPS24,RND2,PIK3C2B,MAPKAP1,PLD3,DDIT4,VEGFC,RPS21,MLST8,PPP2R1A,RRAS2,PTPA,PRKCD,RPS27L,RPS6KA4,EIF3K	
Basal Cell Carcinoma Signaling	1.05E00	1.2909944487358056	2.08E-01	DVL2,BMP4,STK36,KIF7,AXIN1,BMP2,SMO,DVL3,FZD5,FZD9,GSK3B,BMP6,FZD2,WNT5B,FZD7	
Methionine Degradation I (to Homocysteine)	1.06E00	NaN	2.94E-01	AHCYL1,MGMT,AHCY,PRMT1,NSUN4	
Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)	1.06E00	NaN	2.94E-01	MVD,ACAT2,ACAT1,HMGCS1,HADHA	
Polyamine Regulation in Colon Cancer	1.06E00	NaN	2.73E-01	MYC,AZIN1,PSME2,PSME4,PSME3,ODC1	
Cholecystokinin/Gastrin-mediated Signaling	1.06E00	1.3416407864998738	1.98E-01	RND2,SRC,ITPR2,HRAS,FOS,SHC1,RRAS2,JUN,RHOB,MAP2K2,RHOD,PRKCD,SOS1,RHOU,PRKCE,MAP2K3,MAPK7,PTGS2,ELK1,MAP2K5	
Leukocyte Extravasation Signaling	1.07E00	1.3719886811400706	1.82E-01	ABL1,CXCL12,MMP25,ITGA3,MAP2K2,TIMP1,CYBA,PRKCE,RASSF5,PIK3R2,ACTG2,ACTN1,ACTA1,PIK3C2B,SRC,VCAM1,MMP28,CXCR4,ARHGAP4,GNAI1,THY1,MMP2,BTK,F11R,TIMP4,MMP23B,ITGAM,CLDN5,CDH5,WAS,RAP1GAP,PRKCD,VAV3,NCF2,ITGA1,MMP9	
Tight Junction Signaling	1.08E00	NaN	1.86E-01	CPSF2,VAPA,MYL5,CPSF1,CDK4,PPP2R3B,MYL6B,MYLK,MYH11,VTI1B,TGFBR2,NSF,JUN,LLGL1,CSTF2,ARHGEF2,ACTG2,MYL3,ACTA1,NAPB,MYH1,TJP2,TJP1,GPAA1,FOS,F11R,PPP2R1A,CLDN5,PTPA,CPSF3,CSTF3	
Fatty Acid β-oxidation I	1.09E00	NaN	2.50E-01	ACSL3,ACSL4,SLC27A1,IVD,ACADM,HADHA,ECI1,HSD17B8	
Hypoxia Signaling in the Cardiovascular System	1.1E00	-0.7071067811865475	2.15E-01	UBE2Q1,UBE2M,NQO1,HIF1A,CREB5,NFKBIA,JUN,EDN1,HIF1AN,UBE2E2,ATF4,CDC34,VHL,UBE2I	
Sertoli Cell-Sertoli Cell Junction Signaling	1.11E00	NaN	1.85E-01	SPTBN1,AXIN1,TGFBR3,HRAS,TUBB,TUBB2B,ITGA3,JUN,MAP2K2,SORBS1,KEAP1,MTMR2,TUBA1C,GSK3B,ACTG2,ACTA1,ACTN1,SRC,EPN1,TJP2,GUCY1A3,TJP1,TUBG1,TUBB2A,F11R,MAP3K12,CLDN5,RRAS2,WAS,MAP3K20,MAP3K8,MAP2K3,ELK1	
RAR Activation	1.12E00	NaN	1.84E-01	AKR1C3,BMP2,ADH1C,TNIP1,KAT2B,ALDH1A1,JUN,ALDH1A3,RARA,SMARCB1,PRKCE,NR2F6,CSNK2B,PIK3R2,MAPKAPK2,SRC,DHRS3,CSK,SMAD6,SMAD7,ERCC2,CRABP1,PRMT1,FOS,DHRS9,DUSP1,PRKCD,ADCY1,ALDH1A2,IGFBP3,RDH5,CRABP2,RBP5,CARM1,RBP4	
GNRH Signaling	1.12E00	1.4	1.94E-01	GNA11,HRAS,JUN,CAMK2D,GNA15,MAP2K2,SOS1,ATF4,PRKCE,SRC,PAK4,ITPR2,EGR1,GNAI1,CREB5,MAP3K12,FOS,RRAS2,PRKCD,ADCY1,MAP3K8,MAP2K3,MAPK7,DNM1L,ELK1	
Tryptophan Degradation III (Eukaryotic)	1.15E00	NaN	2.86E-01	ACAT2,ACAT1,IDO1,GCDH,HADHA,HSD17B8	
Bladder Cancer Signaling	1.15E00	NaN	2.07E-01	CXCL8,PA2G4,MMP28,FGF2,ABL1,CDK4,HRAS,VEGFC,MMP2,MMP25,MYC,MMP23B,RRAS2,MAP2K2,THBS1,VEGFD,ERBB2,MMP9	
Lipid Antigen Presentation by CD1	1.15E00	NaN	2.69E-01	AP2M1,FCER1G,CANX,AP1B1,CD1C,AP2A2,AP2S1	
Adipogenesis pathway	1.16E00	NaN	1.94E-01	BMP4,LEP,PLIN1,DDIT3,FGF2,BMP2,SIN3B,CEBPD,PPIP5K1,HIF1A,EGR2,LPIN1,KAT2B,HDAC11,SMO,CLOCK,FZD2,KAT2A,ATG7,FZD9,ERCC2,BSCL2,EBF1,FZD5,SOX9,FZD7	
Glioblastoma Multiforme Signaling	1.16E00	0.7844645405527362	1.92E-01	AXIN1,CDK4,HRAS,MYC,SHC1,MTOR,PLCE1,RHOB,MAP2K2,RHOD,TSC2,SOS1,SMO,RHOU,PIK3R2,GSK3B,FZD2,WNT5B,RND2,SRC,PIK3C2B,ITPR2,FZD9,RRAS2,PRKCD,FZD5,PDGFD,FZD7	
Methylglyoxal Degradation III	1.16E00	NaN	3.12E-01	AKR1C3,FAM213B,AKR1B15,AKR1B1,AKR1B10	
Glioma Signaling	1.17E00	1.8073922282301278	2.04E-01	PIK3C2B,CAMK1,PA2G4,ABL1,CDK4,HRAS,CDKN2C,IGF2R,CDKN2B,IDH1,SHC1,MTOR,CAMK2D,RRAS2,MAP2K2,PRKCD,SOS1,PRKCE,PIK3R2,PDGFD	
Inositol Pyrophosphates Biosynthesis	1.17E00	NaN	4.29E-01	IP6K3,PPIP5K1,IP6K1	
NAD Biosynthesis from 2-amino-3-carboxymuconate Semialdehyde	1.17E00	NaN	4.29E-01	ABL1,QPRT,NMNAT2	
Stearate Biosynthesis I (Animals)	1.18E00	NaN	2.50E-01	ACSL3,DHCR24,FAM213B,ACSL4,SLC27A1,AKR1B15,ACOT4,ACOT7,ELOVL6	
ErbB Signaling	1.19E00	NaN	2.09E-01	PIK3C2B,PAK4,HRAS,HBEGF,FOS,SHC1,MTOR,JUN,RRAS2,MAP2K2,PRKCD,SOS1,PRKCE,MAP2K3,GSK3B,ERBB2,PIK3R2,ELK1	
ERK5 Signaling	1.2E00	1.0690449676496976	2.22E-01	SRC,SGK1,HRAS,NGF,CREB5,MYC,FOS,RRAS2,RPS6KB2,ATF4,RPS6KA4,MAP3K8,MAPK7,MAP2K5	
MIF Regulation of Innate Immunity	1.2E00	0.0	2.44E-01	FOS,PLA2G4A,MIF,LY96,NFKBIA,JUN,PLA2G5,CD14,PTGS2,PLA2G2A	
Mechanisms of Viral Exit from Host Cells	1.2E00	NaN	2.44E-01	SH3GL1,VPS25,VPS28,PRKCD,PRKCE,SH3GLB1,SH3GLB2,ACTG2,VPS4A,ACTA1	
IGF-1 Signaling	1.21E00	1.6035674514745464	2.06E-01	IGFBP6,PIK3C2B,SOCS3,IGFBP4,CTGF,HRAS,FOS,SHC1,RRAS2,JUN,MAP2K2,SOS1,IGFBP3,RPS6KB2,SOCS2,IRS2,CSNK2B,PIK3R2,CYR61,ELK1	
Regulation of Actin-based Motility by Rho	1.22E00	2.9824045403173027	2.09E-01	RND2,PAK4,PFN1,ARPC5L,MYL5,PPP1CB,MYL6B,MYLK,ITGA3,RHOB,WAS,RHOD,PIP5K1C,RHOU,ARHGDIA,ACTG2,PI4KA,MYL3,ACTA1	
Glioma Invasiveness Signaling	1.22E00	1.386750490563073	2.28E-01	RND2,PIK3C2B,TIMP4,RRAS2,RHOB,TIMP1,RHOD,RHOU,HRAS,PLAUR,MMP2,PIK3R2,MMP9	
B Cell Receptor Signaling	1.22E00	1.414213562373095	1.90E-01	ABL1,HRAS,INPPL1,SHC1,MTOR,IKBKG,NFKBIA,CAMK2D,JUN,MAP2K2,SOS1,RPS6KB2,ATF4,GSK3B,PIK3R2,RASSF5,ETS1,PIK3C2B,APBB1IP,CSK,EGR1,CREB5,BTK,BCL2L1,MAP3K12,EBF1,RRAS2,PAG1,VAV3,LYN,MAP2K3,MAP3K8,ELK1	
Gluconeogenesis I	1.23E00	NaN	2.80E-01	ENO1,GAPDH,ALDOA,FBP1,ME2,ME1,ALDOC	
Glycolysis I	1.23E00	NaN	2.80E-01	ENO1,PKM,GAPDH,ALDOA,FBP1,PFKL,ALDOC	
HIF1α Signaling	1.24E00	NaN	2.06E-01	SLC2A5,PIK3C2B,MMP28,HRAS,VEGFC,MMP2,HIF1A,TCEB2,MMP25,NAA10,SLC2A3,P4HTM,RRAS2,MMP23B,JUN,EDN1,VEGFD,MAPK7,PIK3R2,VHL,MMP9	
1,25-dihydroxyvitamin D3 Biosynthesis	1.25E00	NaN	6.67E-01	POR,CYP2R1	
Aspartate Biosynthesis	1.25E00	NaN	6.67E-01	GOT1,GOT2	
Biotin-carboxyl Carrier Protein Assembly	1.25E00	NaN	6.67E-01	HLCS,ACACA	
D-glucuronate Degradation I	1.25E00	NaN	6.67E-01	DCXR,CRYL1	
Diphthamide Biosynthesis	1.25E00	NaN	6.67E-01	DPH5,DPH6	
Glutamate Degradation II	1.25E00	NaN	6.67E-01	GOT1,GOT2	
Glutathione Biosynthesis	1.25E00	NaN	6.67E-01	GCLM,GSS	
N-acetylglucosamine Degradation I	1.25E00	NaN	6.67E-01	GNPDA1,AMDHD2	
NADH Repair	1.25E00	NaN	6.67E-01	NAXE,GAPDH	
Thyroid Hormone Biosynthesis	1.25E00	NaN	6.67E-01	CTSD,TPO	
GM-CSF Signaling	1.25E00	1.9414506867883021	2.26E-01	RUNX1,ETS1,PIK3C2B,HRAS,SHC1,BCL2L1,CAMK2D,RRAS2,MAP2K2,CSF2RA,SOS1,LYN,PIK3R2,ELK1	
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	1.25E00	NaN	1.79E-01	SOCS3,AXIN1,CXCL12,IL17RC,HRAS,IL6,CEBPG,MYC,IKBKG,CAMK2D,PLCE1,MAP2K2,ATF4,VEGFD,LTBR,GSK3B,FZD2,WNT5B,SFRP4,CXCL8,PIK3C2B,SELE,MIF,VEGFC,FZD9,CREB5,PRKCD,FZD5,MAP2K3,SFRP1,PDGFD,SFRP2,FRZB,FGF2,CEBPD,IRAK1,NFKBIA,JUN,CCL2,DKK3,SMO,PRKCE,PIK3R2,MAPKAPK2,FCGR3A/FCGR3B,SRC,VCAM1,C5AR1,DAAM1,IL18RAP,FOS,RRAS2,FZD7	
Breast Cancer Regulation by Stathmin1	1.26E00	NaN	1.88E-01	CAMK1,PPP1R3C,PPP1CB,PPP2R3B,HRAS,TUBB,PPP1R14B,TUBB2B,SHC1,CAMK2D,GNG11,MAP2K2,SOS1,PRKCE,ARHGEF2,TUBA1C,PIK3R2,GNG5,PIK3C2B,ARHGEF4,ITPR2,TUBG1,TUBB2A,GNG2,GNAI1,PPP1R14A,PPP1R11,GNG10,ARHGEF5,PPP2R1A,RRAS2,PTPA,ARHGEF16,PRKCD,ADCY1,ARHGEF6	
Erythropoietin Signaling	1.28E00	NaN	2.24E-01	SOCS3,SRC,PIK3C2B,HRAS,SHC1,FOS,NFKBIA,JUN,RRAS2,MAP2K2,PRKCD,SOS1,PRKCE,PIK3R2,ELK1	
Paxillin Signaling	1.28E00	0.0	2.08E-01	PIK3C2B,SRC,PAK4,PARVA,CSK,HRAS,ITGA10,DOCK1,ITGA3,RRAS2,TLN2,ITGAM,ITGA11,SOS1,ARHGEF6,ITGA1,PIK3R2,ACTG2,ITGA7,ACTN1,ACTA1	
IL-17 Signaling	1.3E00	NaN	2.22E-01	CXCL8,PIK3C2B,HRAS,IL17RC,IL6,JUN,RRAS2,CCL2,MAP2K2,TIMP1,MAP2K3,GSK3B,PIK3R2,PTGS2,ELK1,MAPKAPK2	
Role of NFAT in Regulation of the Immune Response	1.31E00	1.0	1.93E-01	FYN,HLA-DOA,CD4,GNA11,FCER1A,HRAS,IKBKG,HLA-DRB1,NFKBIA,JUN,GNG11,GNA15,MAP2K2,SOS1,GSK3B,PIK3R2,GNG5,FCGR3A/FCGR3B,PIK3C2B,ITPR2,GNG2,GNAI1,GNAZ,GNG10,BTK,RCAN1,FOS,RRAS2,LYN,FCER1G,MS4A2,CD86,RCAN2	
Granulocyte Adhesion and Diapedesis	1.31E00	NaN	1.92E-01	FPR3,CXCL12,SDC4,MMP25,CCL3,CCL4L1/CCL4L2,ITGA3,CCL13,CCL3L1,CCL8,CCL2,CCL3L3,CXCL14,CSF3R,CXCL8,VCAM1,SELE,C5AR1,MMP28,CXCR4,GNAI1,THY1,MMP2,GLG1,IL18RAP,CXCL16,ITGAM,MMP23B,CLDN5,CDH5,ITGA1,CCL18,CXCL2,MMP9	
Intrinsic Prothrombin Activation Pathway	1.31E00	1.889822365046136	2.76E-01	COL1A2,COL1A1,COL5A3,F8,F13A1,COL18A1,THBD,COL3A1	
Gαq Signaling	1.31E00	2.5018511664883785	1.97E-01	ADRBK1,GNA11,HMOX1,IKBKG,NFKBIA,GNG11,GYS1,GNA15,RHOB,MAP2K2,RHOD,RHOU,PRKCE,PIK3R2,GSK3B,GNG5,ADRA1B,RND2,PIK3C2B,PLD3,ITPR2,CSK,GNG2,RGS16,GNG10,BTK,PRKCD,ELK1,ADRA1A	
Retinol Biosynthesis	1.32E00	NaN	2.65E-01	CEL,AADAC,DHRS3,CES1,DHRS9,LIPE,LIPG,CES2,RBP5	
Thrombopoietin Signaling	1.33E00	-0.2773500981126146	2.36E-01	MYC,FOS,PIK3C2B,SHC1,RRAS2,JUN,MAP2K2,PRKCD,SOS1,HRAS,PRKCE,IRS2,PIK3R2	
PI3K/AKT Signaling	1.33E00	-0.2182178902359924	2.03E-01	GDF15,HRAS,PPP2R3B,INPPL1,EIF4EBP1,SHC1,MTOR,IKBKG,ITGA3,NFKBIA,GYS1,MAP2K2,TSC2,SOS1,RPS6KB2,PIK3R2,GSK3B,MCL1,BCL2L1,PPP2R1A,RRAS2,LIMS1,PTPA,MAP3K8,PTGS2	
SAPK/JNK Signaling	1.33E00	1.4142135623730951	2.13E-01	PIK3C2B,GNG2,MAPK8IP2,HRAS,MAPK8IP3,HNRNPK,SHC1,MAP3K12,RRAS2,GNG11,JUN,GADD45A,DUSP10,MAP3K20,SOS1,FCER1G,PIK3R2,GNG5,ELK1,MAP4K4	
Cysteine Biosynthesis III (mammalia)	1.34E00	NaN	3.16E-01	AHCYL1,CBS/CBSL,MGMT,AHCY,PRMT1,NSUN4	
Protein Ubiquitination Pathway	1.34E00	NaN	1.84E-01	CDC20,PSMD7,PSMB10,USP5,DNAJB4,HSPA1A/HSPA1B,DNAJC15,DNAJB2,TCEB2,HSPA5,USP39,UCHL1,HSPA4,STUB1,DNAJC4,USP47,HSPE1,PSMA3,PSMD14,NEDD4L,BIRC3,AMFR,PSMB5,UBE2M,UBE2Q1,MED20,USP36,HSPA9,PSME2,DNAJC1,THOP1,PSMB6,HSPA2,HSPA8,PSMB7,PSMB2,DNAJB11,PSMA4,BAP1,HSPA13,UBE2E2,HSPB7,DNAJB6,UBA1,CDC34,VHL,UBE2I	
Neuregulin Signaling	1.35E00	1.697749375254331	2.16E-01	SRC,ADAM17,HRAS,HBEGF,MYC,SHC1,ITGA3,MTOR,RRAS2,MAP2K2,PRKCD,SOS1,RPS6KB2,PRKCE,DLG4,ERBB2,PIK3R2,ELK1,MATK	
Calcium Transport I	1.35E00	NaN	4.00E-01	ATP2B1,ATP2C1,ANXA5,ATP2A2	
Dolichyl-diphosphooligosaccharide Biosynthesis	1.35E00	NaN	4.00E-01	ALG3,DPM2,DPAGT1,ALG8	
Arginine Degradation VI (Arginase 2 Pathway)	1.37E00	NaN	5.00E-01	ARG2,PYCR2,PYCR1	
Glycogen Biosynthesis II (from UDP-D-Glucose)	1.37E00	NaN	5.00E-01	GYS1,GBE1,GYG2	
Proline Biosynthesis II (from Arginine)	1.37E00	NaN	5.00E-01	PADI4,PYCR2,PYCR1	
Selenocysteine Biosynthesis II (Archaea and Eukaryotes)	1.37E00	NaN	5.00E-01	SEPHS2,SARS,SARS2	
Thioredoxin Pathway	1.37E00	NaN	5.00E-01	TXN,TXNRD2,TXNRD1	
UDP-N-acetyl-D-glucosamine Biosynthesis II	1.37E00	NaN	5.00E-01	FMO3,GFPT1,GFPT2	
Zymosterol Biosynthesis	1.37E00	NaN	5.00E-01	MSMO1,TM7SF2,CYP51A1	
Superpathway of Inositol Phosphate Compounds	1.37E00	NaN	1.92E-01	SOCS3,PTPN23,PPP1R1A,PPFIBP2,PPIP5K1,NT5C,NUDT14,INPPL1,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,IP6K3,PLCE1,DUSP10,IP6K1,MTMR2,PIK3R2,ALPL,PI4KA,PI4KB,PIK3C2B,PPP1R1B,PPP1R14A,PAWR,FIG4,DUSP14,ITPK1,PIP5K1C,PPP1R16B,PTPA,PDXP,DUSP1,CILP	
Molecular Mechanisms of Cancer	1.38E00	NaN	1.78E-01	BMP4,AXIN1,NCSTN,CDKN2C,HRAS,MYC,TGFBR2,ITGA3,CAMK2D,GNA15,RHOB,MAP2K2,CCND3,GSK3B,HIPK2,FZD2,BIRC3,WNT5B,RND2,PIK3C2B,ARHGEF4,STK36,FZD9,GNAZ,BCL2L1,CCND2,ARHGEF16,PRKCD,ARHGEF6,FZD5,MAP2K3,NOTCH1,FYN,RALA,PA2G4,BMP2,GNA11,CDK4,ABL1,HIF1A,CDKN2B,DIABLO,SHC1,NFKBIA,JUN,RHOD,SOS1,SMO,RHOU,PRKCE,ARHGEF2,PIK3R2,CHEK2,SRC,PAK4,SMAD6,SMAD7,GNAI1,ARHGEF5,FOS,RRAS2,ADCY1,ELK1,BMP6,FZD7	
VEGF Family Ligand-Receptor Interactions	1.38E00	0.0	2.24E-01	PIK3C2B,HRAS,VEGFC,PLA2G2A,FOS,SHC1,PLA2G4A,RRAS2,MAP2K2,PRKCD,PLA2G5,SOS1,VEGFD,PRKCE,PIK3R2,KDR,NRP1	
D-myo-inositol-5-phosphate Metabolism	1.38E00	NaN	2.00E-01	SOCS3,PTPN23,PPP1R1A,PPFIBP2,PPIP5K1,NT5C,NUDT14,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,PLCE1,DUSP10,MTMR2,ALPL,PPP1R1B,PPP1R14A,FIG4,PAWR,DUSP14,ITPK1,PPP1R16B,PTPA,PDXP,DUSP1,CILP	
Ovarian Cancer Signaling	1.46E00	NaN	2.06E-01	PA2G4,AXIN1,LHCGR,CDK4,ABL1,HRAS,MTOR,MAP2K2,EDN1,SMO,RPS6KB2,VEGFD,PIK3R2,GSK3B,FZD2,WNT5B,SRC,PIK3C2B,VEGFC,MMP2,FZD9,RRAS2,EDNRA,FZD5,PTGS2,MMP9,FZD7	
Germ Cell-Sertoli Cell Junction Signaling	1.47E00	NaN	2.00E-01	AXIN1,HRAS,TUBB,TUBB2B,TGFBR2,ITGA3,RHOB,MAP2K2,SORBS1,RHOD,KEAP1,RHOU,MTMR2,TUBA1C,ACTG2,PIK3R2,ACTA1,ACTN1,RND2,SRC,PIK3C2B,EPN1,PAK4,TJP1,TUBG1,TUBB2A,LAMC3,MAP3K12,CDH2,RRAS2,MAP3K8,MAP2K3	
TR/RXR Activation	1.48E00	NaN	2.24E-01	PIK3C2B,UCP2,GPS2,AKR1C3,THRA,ME1,HIF1A,THRSP,KLF9,ENO1,HP,MTOR,LDLR,COL6A3,PDE3B,SLC16A2,ACACA,PIK3R2,RCAN2	
Acetone Degradation I (to Methylglyoxal)	1.49E00	NaN	2.96E-01	POR,FAM213B,CYP4B1,CYP4X1,AKR1B15,CYP1B1,CYP51A1,CYP2C8	
Estrogen-Dependent Breast Cancer Signaling	1.49E00	NaN	2.38E-01	SRC,PIK3C2B,HRAS,CREB5,HSD17B8,FOS,JUN,RRAS2,ATF4,AKR1B15,PIK3R2,ELK1,AKR1C4,ESR1,HSD17B14	
PCP pathway	1.49E00	1.6035674514745464	2.38E-01	RSPO3,DVL2,PFN1,JUN,DAAM1,SMO,CTHRC1,DVL3,FZD5,FZD9,SDC4,JUNB,FZD2,WNT5B,FZD7	
Reelin Signaling in Neurons	1.51E00	NaN	2.28E-01	FYN,SRC,APOE,PIK3C2B,ARHGEF4,MAPK8IP2,MAPK8IP3,RELN,ARHGEF5,ITGA3,ARHGEF16,ARHGEF6,LYN,ARHGEF2,LRP8,ITGA1,GSK3B,PIK3R2	
GDNF Family Ligand-Receptor Interactions	1.51E00	NaN	2.35E-01	DOK5,PIK3C2B,DOK2,ITPR2,HRAS,GFRA2,FOS,SHC1,RRAS2,PDLIM7,JUN,MAP2K2,SOS1,IRS2,PIK3R2,RET	
IL-10 Signaling	1.51E00	NaN	2.35E-01	CCR1,SOCS3,ARG2,IL6,IL18RAP,FOS,HMOX1,IKBKG,NFKBIA,JUN,IL10RA,CD14,MAP2K3,LBP,ELK1,MAP4K4	
Leucine Degradation I	1.52E00	NaN	4.44E-01	BCAT2,IVD,HMGCL,ACADM	
Prostanoid Biosynthesis	1.52E00	NaN	4.44E-01	PTGIS,PTGES2,PTGDS,PTGS2	
Mevalonate Pathway I	1.53E00	NaN	3.85E-01	MVD,ACAT2,ACAT1,HMGCS1,HADHA	
Mouse Embryonic Stem Cell Pluripotency	1.54E00	0.6546536707079772	2.21E-01	PIK3C2B,BMP4,AXIN1,HRAS,FZD9,ID3,MYC,ID1,DVL2,RRAS2,MAP2K2,SOS1,SMO,DVL3,FZD5,GSK3B,PIK3R2,FZD2,ID4,ZFP42,FZD7	
Wnt/Ca+ pathway	1.59E00	1.507556722888818	2.50E-01	DVL2,PLCE1,AXIN1,SMO,ATF4,DVL3,FZD5,FZD9,GSK3B,CREB5,ROR1,FZD2,WNT5B,FZD7	
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	1.59E00	-0.50709255283711	2.00E-01	APOE,APOB,PPP1R3C,PPP1CB,PPP2R3B,ARG2,PPP1R14B,SPI1,LYZ,IKBKG,NFKBIA,JUN,RHOB,RHOD,CYBA,RHOU,PRKCE,S100A8,PIK3R2,RND2,PIK3C2B,PPP1R14A,PPP1R11,SAA4,FOS,MAP3K12,PPP2R1A,ORM1,PTPA,PRKCD,CAT,NCF2,APOC1,ORM2,MAP3K8,RBP4	
IL-6 Signaling	1.61E00	0.20851441405707477	2.16E-01	SOCS3,HRAS,IL6,SHC1,IKBKG,JUN,NFKBIA,MAP2K2,SOS1,PIK3R2,LBP,CSNK2B,MAPKAPK2,MCL1,CXCL8,PIK3C2B,IL18RAP,COL1A1,FOS,RRAS2,CD14,HSPB7,MAP2K3,ELK1,MAP4K4	
G Beta Gamma Signaling	1.61E00	0.0	2.27E-01	SRC,GNA11,GNG2,GNAI1,HRAS,HBEGF,GNAZ,GNG10,BTK,SHC1,RRAS2,GNG11,GNA15,PRKCD,ADCY1,ARHGEF6,SOS1,CAV1,PRKCE,GNG5	
PDGF Signaling	1.61E00	1.4142135623730951	2.34E-01	SRC,PIK3C2B,SPHK2,ABL1,HRAS,INPPL1,MYC,FOS,SHC1,RRAS2,JUN,MAP2K2,SOS1,CAV1,CSNK2B,PIK3R2,ELK1,PDGFD	
Galactose Degradation I (Leloir Pathway)	1.62E00	NaN	6.00E-01	GALK1,GALE,GALM	
RhoGDI Signaling	1.63E00	-1.7320508075688772	2.02E-01	GDI1,GNA11,MYL5,MYL6B,ITGA3,GNG11,GNA15,RHOB,RHOD,RHOU,ARHGEF2,ACTG2,GNG5,PI4KA,MYL3,ACTA1,RND2,SRC,ARHGEF4,PAK4,ARPC5L,GNG2,ARHGAP4,GNAI1,GNAZ,GNG10,ARHGEF5,CDH2,CDH12,CDH5,PIP5K1C,ARHGEF16,ARHGEF6,ARHGDIA,ESR1	
IL-17A Signaling in Fibroblasts	1.64E00	NaN	2.86E-01	FOS,IKBKG,NFKBIA,JUN,CCL2,CEBPD,IL17RC,GSK3B,IL6,NFKBIZ	
Insulin Receptor Signaling	1.65E00	1.1338934190276817	2.12E-01	FYN,SOCS3,SGK1,PPP1R3C,PPP1CB,HRAS,LIPE,INPPL1,PPP1R14B,PTPRF,EIF4EBP1,SHC1,MTOR,GYS1,MAP2K2,PDE3B,TSC2,SOS1,RPS6KB2,IRS2,GSK3B,PIK3R2,PIK3C2B,PPP1R14A,PPP1R11,ACLY,RRAS2,ASIC1	
Thrombin Signaling	1.65E00	1.975658322294524	2.00E-01	CAMK1,GNA11,MYL5,PPP1CB,HRAS,MYL6B,MYLK,SHC1,CAMK2D,PLCE1,GNG11,GNA15,RHOB,MAP2K2,RHOD,SOS1,RHOU,PRKCE,ARHGEF2,PIK3R2,GNG5,MYL3,RND2,SRC,PIK3C2B,ARHGEF4,ITPR2,GNG2,GNAI1,GNAZ,GNG10,ARHGEF5,RRAS2,ARHGEF16,PRKCD,ADCY1,ARHGEF6,ELK1	
p53 Signaling	1.66E00	-0.24253562503633297	2.24E-01	PIK3C2B,GADD45B,RRM2B,TNFRSF10B,CDK4,PERP,HIF1A,SERPINE2,BCL2L1,KAT2B,JUN,CCND2,GADD45A,THBS1,COQ8A,GNL3,GSK3B,PIK3R2,HIPK2,TRIM29,PIDD1,CHEK2	
Phospholipase C Signaling	1.67E00	2.3333333333333335	1.94E-01	PEBP1,FYN,RALA,MYL5,PPP1CB,HRAS,MYL6B,TGM2,HMOX1,SHC1,ITGA3,GNG11,PLCE1,RHOB,MAP2K2,AHNAK,RHOD,HDAC11,PLA2G5,SOS1,RHOU,ATF4,PRKCE,ARHGEF2,GNG5,MYL3,RND2,SRC,ARHGEF4,PLD3,ITPR2,GNG2,PPP1R14A,CREB5,PLA2G2A,GNG10,BTK,ARHGEF5,PLA2G4A,RRAS2,ARHGEF16,PRKCD,ADCY1,ARHGEF6,LYN,FCER1G	
4-hydroxyproline Degradation I	1.68E00	NaN	1.00E00	ALDH4A1,HOGA1	
GDP-L-fucose Biosynthesis I (from GDP-D-mannose)	1.68E00	NaN	1.00E00	TSTA3,GMDS	
Proline Degradation	1.68E00	NaN	1.00E00	ALDH4A1,LOC102724788/PRODH	
Taurine Biosynthesis	1.68E00	NaN	1.00E00	CSAD,CDO1	
Triacylglycerol Degradation	1.68E00	NaN	3.20E-01	FAAH,ABHD12,CEL,AADAC,CES1,LIPE,LIPG,NDST2	
Cleavage and Polyadenylation of Pre-mRNA	1.69E00	NaN	4.17E-01	CPSF2,CPSF1,CSTF2,CPSF3,CSTF3	
Glutaryl-CoA Degradation	1.69E00	NaN	4.17E-01	ACAT2,ACAT1,GCDH,HADHA,HSD17B8	
Agranulocyte Adhesion and Diapedesis	1.69E00	NaN	2.01E-01	AOC3,MYL5,CXCL12,MYL6B,MYH11,SDC4,MMP25,CCL3,CCL4L1/CCL4L2,ITGA3,CCL13,CCL3L1,CCL8,CCL2,CCL3L3,CXCL14,ACTG2,MYL3,ACTA1,MYH1,CXCL8,VCAM1,SELE,C5AR1,MMP28,CXCR4,GNAI1,MMP2,GLG1,CXCL16,MMP23B,PODXL2,CLDN5,CDH5,ITGA1,CXCL2,CCL18,MMP9	
Superoxide Radicals Degradation	1.73E00	NaN	5.00E-01	NQO1,CAT,CYGB,GPX7	
Signaling by Rho Family GTPases	1.76E00	2.137186834969645	1.97E-01	GNA11,WASF3,MYL5,MYL6B,MYLK,CDC42EP2,SLC9A1,CLIP1,ITGA3,GNG11,JUN,GNA15,RHOB,MAP2K2,RHOD,RHOU,ARHGEF2,PIK3R2,ACTG2,GNG5,PI4KA,MYL3,ACTA1,RND2,PIK3C2B,ARHGEF4,NOX4,PAK4,ARPC5L,GNG2,GNAI1,GNAZ,PKN1,GNG10,FOS,ARHGEF5,MAP3K12,CDH2,CDH12,CDH5,WAS,PIP5K1C,ARHGEF16,NCF2,ARHGEF6,ELK1	
Aldosterone Signaling in Epithelial Cells	1.77E00	0.7745966692414834	2.11E-01	SGK1,DNAJB4,HSPA1A/HSPA1B,DNAJB2,DNAJC15,HSPA5,SLC9A1,HSPA4,PLCE1,MAP2K2,DNAJC4,HSPE1,SOS1,PRKCE,PIK3R2,PI4KA,AHCY,PIK3C2B,ITPR2,SLC12A2,HSPA9,DNAJC1,HSPA2,HSPA8,DUSP1,PIP5K1C,DNAJB11,PRKCD,HSPA13,ASIC1,HSPB7,DNAJB6	
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis	1.78E00	NaN	2.17E-01	SOCS3,PTPN23,PPP1R1A,PPFIBP2,PPIP5K1,NUDT14,NT5C,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,DUSP10,MTMR2,ALPL,PPP1R1B,PPP1R14A,FIG4,PAWR,DUSP14,ITPK1,PPP1R16B,PTPA,PDXP,DUSP1,CILP	
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis	1.78E00	NaN	2.17E-01	SOCS3,PTPN23,PPP1R1A,PPFIBP2,PPIP5K1,NUDT14,NT5C,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,DUSP10,MTMR2,ALPL,PPP1R1B,PPP1R14A,FIG4,PAWR,DUSP14,ITPK1,PPP1R16B,PTPA,PDXP,DUSP1,CILP	
3-phosphoinositide Degradation	1.78E00	NaN	2.12E-01	SOCS3,PTPN23,PPP1R1A,PTPMT1,PPFIBP2,PPIP5K1,NT5C,NUDT14,INPPL1,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,DUSP10,MTMR2,ALPL,PPP1R1B,MTMR14,PPP1R14A,PAWR,FIG4,DUSP14,ITPK1,PPP1R16B,PTPA,PDXP,DUSP1,CILP	
Tec Kinase Signaling	1.79E00	1.6329931618554523	2.10E-01	FYN,GNA11,FCER1A,TNFSF10,ITGA3,GNG11,GNA15,RHOB,RHOD,RHOU,PRKCE,PIK3R2,ACTG2,GNG5,ACTA1,TNFRSF21,RND2,SRC,PIK3C2B,PAK4,TNFRSF10B,GNG2,GNAI1,GNAZ,GNG10,BTK,FOS,WAS,PRKCD,VAV3,LYN,FCER1G,MS4A2	
Estrogen Biosynthesis	1.8E00	NaN	2.89E-01	POR,AKR1C3,CYP4B1,CYP4X1,AKR1B15,AKR1C4,CYP1B1,CYP51A1,HSD17B14,HSD17B8,CYP2C8	
Remodeling of Epithelial Adherens Junctions	1.82E00	1.3416407864998738	2.50E-01	SRC,NME1,RALA,ARPC5L,TUBG1,TUBB2A,TUBB,CLIP1,TUBB2B,RAB5A,TUBA1C,ACTG2,DNM1L,HGS,MAPRE3,ACTA1,ACTN1	
3-phosphoinositide Biosynthesis	1.83E00	NaN	2.12E-01	SOCS3,PTPN23,PPP1R1A,PPFIBP2,PPIP5K1,NT5C,NUDT14,ACP5,STYXL1,NUDT2,PPP4C,PPP1R14B,PTPRF,CA3,DUSP10,MTMR2,PIK3R2,ALPL,PI4KA,PI4KB,PIK3C2B,PPP1R1B,PPP1R14A,FIG4,PAWR,DUSP14,ITPK1,PPP1R16B,PTPA,PDXP,DUSP1,PIP5K1C,CILP	
Ephrin B Signaling	1.84E00	0.0	2.47E-01	ITSN1,CXCR4,AXIN1,GNA11,GNG2,CXCL12,GNAI1,HRAS,GNAZ,HNRNPK,GNG10,EPHB6,EFNB2,GNG11,GNA15,VAV3,EPHB3,GNG5	
Vitamin-C Transport	1.85E00	NaN	4.00E-01	TXN,GSTO2,TXNRD2,GLRX,TXNRD1,SLC2A3	
Purine Nucleotides De Novo Biosynthesis II	1.87E00	NaN	4.55E-01	ADSL,ADSSL1,IMPDH2,PAICS,ATIC	
Neurotrophin/TRK Signaling	1.89E00	1.5	2.54E-01	PIK3C2B,SPRY1,HRAS,CREB5,NGF,FOS,SHC1,JUN,RRAS2,MAP2K2,NTRK3,SPRY2,SOS1,ATF4,MAP2K3,PIK3R2,MAP2K5	
Glutathione Redox Reactions II	1.97E00	NaN	7.50E-01	GSR,TXNDC12,GLRX	
L-cysteine Degradation I	1.97E00	NaN	7.50E-01	GOT1,CDO1,GOT2	
N-acetylglucosamine Degradation II	1.97E00	NaN	7.50E-01	NAGK,GNPDA1,AMDHD2	
Phenylethylamine Degradation I	1.97E00	NaN	7.50E-01	AOC3,ALDH2,ALDH3A2	
Glycoaminoglycan-protein Linkage Region Biosynthesis	1.97E00	NaN	5.71E-01	B4GALT7,B3GALT6,XYLT2,B3GAT3	
LPS/IL-1 Mediated Inhibition of RXR Function	1.99E00	-0.2773500981126146	2.04E-01	APOE,ALDH4A1,GSTM5,HS2ST1,ABCG1,CES2,GSTT1,HS3ST3A1,IRAK1,JUN,GSTM2,ALDH1A1,ALDH1A3,RARA,ALDH3A2,ACSL4,FMO1,LBP,ALDH3A1,FMO4,HMGCS1,ALDH5A1,ALDH1B1,GSTM1,ACSL3,FMO3,FMO2,GSTM3,MGMT,IL18RAP,LY96,SMOX,ALDH1A2,CAT,APOC1,NR5A2,CD14,SLC27A1,ALDH3B1,PLTP,NDST2,ABCC3,GSTO2,MAOA,CYP2C8	
Wnt/β-catenin Signaling	2E00	1.671258043593467	2.13E-01	SFRP2,FRZB,AXIN1,TGFBR3,PPP2R3B,TLE1,MYC,TGFBR2,SOX17,JUN,DKK3,RARA,SMO,GSK3B,CSNK2B,FZD2,ACVR1C,WNT5B,SOX7,SFRP4,SRC,AXIN2,FZD9,DVL2,PPP2R1A,CDH2,CDH12,CDH5,PTPA,NR5A2,DVL3,FZD5,SOX9,SFRP1,PIN1,FZD7	
Colanic Acid Building Blocks Biosynthesis	2.02E00	NaN	4.29E-01	TSTA3,GMPPB,GMDS,GMPPA,GALK1,GALE	
Phenylalanine Degradation IV (Mammalian, via Side Chain)	2.02E00	NaN	4.29E-01	ALDH2,SMOX,ALDH3A2,GOT1,GOT2,MAOA	
Xenobiotic Metabolism Signaling	2.02E00	NaN	1.98E-01	CAMK1,MAF,PPP2R3B,HRAS,IL6,CES2,CAMK2D,ALDH1A1,GSTM2,MAP2K2,ALDH3A2,KEAP1,FMO4,ALDH3A1,ALDH1B1,PIK3C2B,FMO2,GSTM3,MAP3K12,PPP2R1A,SMOX,PTPA,PRKCD,ALDH1A2,ALDH3B1,MAP2K3,MAPK7,MAP2K5,ALDH4A1,GSTM5,NQO2,HS2ST1,GSTT1,HS3ST3A1,HMOX1,CES1,ALDH1A3,PRKCE,FMO1,PIK3R2,ALDH5A1,GSTM1,FMO3,MGMT,NQO1,CYP1B1,RRAS2,CAT,MAP3K8,NDST2,GSTO2,ABCC3,CYP2C8,MAOA	
Ephrin Receptor Signaling	2.03E00	2.041241452319315	2.13E-01	FYN,ITSN1,AXIN1,GNA11,ABL1,CXCL12,HRAS,GRINA,EPHB6,EFNB2,SHC1,ITGA3,GNG11,GNA15,MAP2K2,SORBS1,SOS1,VEGFD,ATF4,GNG5,SRC,PAK4,ANGPT1,CXCR4,ARPC5L,GNG2,GNAI1,VEGFC,GNAZ,CREB5,GNG10,SDCBP,RRAS2,WAS,EPHB3,PDGFD,MAP4K4	
Ketogenesis	2.07E00	NaN	5.00E-01	ACAT2,ACAT1,HMGCL,HMGCS1,HADHA	
Acute Myeloid Leukemia Signaling	2.12E00	1.212678125181665	2.53E-01	RUNX1,CSF3R,PIK3C2B,HRAS,SPI1,CSF1R,EIF4EBP1,IDH1,MYC,MTOR,RRAS2,MAP2K2,CSF2RA,RARA,SOS1,RPS6KB2,KIT,MAP2K3,PIK3R2,MAP2K5	
Oxidative Phosphorylation	2.22E00	NaN	2.39E-01	ATP5G1,NDUFA9,ATP5D,NDUFA7,UQCRH,COX8A,NDUFB10,NDUFB9,NDUFA10,ATP5I,NDUFAB1,NDUFV1,COX17,NDUFS7,SURF1,COX7A2L,NDUFA13,VPS9D1,NDUFS8,UQCR10,CYC1,CYB5A,ATPAF2,NDUFS3,UQCRC1,COX15	
Serotonin Degradation	2.24E00	NaN	2.69E-01	ALDH4A1,ALDH1B1,ADH1C,LARGE1,ALDH2,ALDH1A1,DHRS9,SMOX,ALDH1A3,ALDH3A2,ALDH1A2,PECR,ALDH3B1,B3GAT3,ALDH3A1,ADHFE1,MAOA,DHRS4	
FAK Signaling	2.27E00	NaN	2.53E-01	CAPN5,PIK3C2B,SRC,FYN,PAK4,CAPN6,CSK,HRAS,DOCK1,ITGA3,CAPNS1,RRAS2,TLN2,MAP2K2,WAS,SOS1,ARHGEF6,CAPN2,PIK3R2,ACTG2,TNS1,ACTA1	
Caveolar-mediated Endocytosis Signaling	2.31E00	NaN	2.68E-01	FYN,SRC,ITSN1,ABL1,COPE,FLOT1,ITGA10,RAB5A,CD55,ITGA3,ITGAM,ITGA11,FLNA,FLNC,CAV1,ITGA1,ACTG2,ITGA7,ACTA1	
Superpathway of Methionine Degradation	2.41E00	NaN	3.44E-01	AHCYL1,CBS/CBSL,MGMT,MCEE,PCCB,GOT1,CDO1,GOT2,AHCY,PRMT1,NSUN4	
ERK/MAPK Signaling	2.43E00	0.4685212856658182	2.19E-01	FYN,PPP1R3C,PPP1CB,PPP2R3B,HRAS,PPP1R14B,EIF4EBP1,MYC,SHC1,ITGA3,MAP2K2,ETS2,PLA2G5,SOS1,PRKCE,ATF4,PIK3R2,ETS1,MYCN,SRC,PIK3C2B,PAK4,PPP1R14A,PPP1R11,MKNK2,CREB5,PLA2G2A,FOS,DOCK1,PLA2G4A,PPP2R1A,RRAS2,TLN2,H3F3A/H3F3B,PTPA,DUSP1,PRKCD,RPS6KA4,HSPB7,ELK1,ESR1	
LXR/RXR Activation	2.44E00	0.5773502691896257	2.40E-01	APOE,APOB,CD36,ABCG1,ARG2,IL6,IRF3,LYZ,CCL2,SAA1,S100A8,LBP,CYP51A1,AGT,SAA2,SAA4,IL18RAP,LY96,LDLR,TF,ORM1,APOC1,CD14,ORM2,ACACA,PLTP,PTGS2,MMP9,RBP4	
Acute Phase Response Signaling	2.49E00	1.2247448713915892	2.25E-01	SOCS3,HRAS,SERPINA3,IL6,HNRNPK,IRAK1,C1R,HMOX1,SHC1,MTOR,IKBKG,NFKBIA,JUN,F8,MAP2K2,SAA1,SOS1,CFB,SOCS2,LBP,PIK3R2,AGT,C4BPB,SAA2,SAA4,CRABP1,FOS,HP,RRAS2,TF,ORM1,ORM2,MAP2K3,CRABP2,ELK1,RBP5,C2,RBP4	
phagosome maturation	2.49E00	NaN	2.42E-01	ATP6V0B,ATP6V1D,VPS28,PRDX5,DYNLT1,TUBB,VTI1B,ATP6AP1,TUBB2B,NSF,RAB5A,HLA-DRB1,TUBA1C,TPO,NAPB,NOX4,VPS18,TUBG1,TUBB2A,CANX,GPAA1,ATP6V1E1,LAMP2,HLA-DRB4,ATP6V1F,NCF2,ATP6V0A2,VPS37A,ATP6V1B2	
CXCR4 Signaling	2.51E00	1.0954451150103321	2.30E-01	CD4,GNA11,MYL5,CXCL12,HRAS,MYL6B,JUN,GNG11,GNA15,RHOB,MAP2K2,RHOD,RHOU,PRKCE,PIK3R2,GNG5,MYL3,RND2,SRC,PIK3C2B,PAK4,CXCR4,ITPR2,EGR1,GNG2,GNAI1,GNAZ,GNG10,FOS,DOCK1,RRAS2,PRKCD,ADCY1,LYN,ELK1	
Inosine-5'-phosphate Biosynthesis II	2.52E00	NaN	1.00E00	ADSL,PAICS,ATIC	
Mitochondrial Dysfunction	2.65E00	NaN	2.28E-01	ATP5G1,NDUFA9,NDUFA7,ATP5D,UQCRH,PRDX5,COX8A,ACO2,NCSTN,NDUFB10,NDUFB9,NDUFA10,NDUFAB1,ATP5I,NDUFV1,COX17,UCP2,NDUFS7,GLRX2,SURF1,COX7A2L,LRRK2,NDUFAF2,GPX7,NDUFA13,VPS9D1,GSR,NDUFS8,UQCR10,CYC1,CAT,BACE2,ATPAF2,CYB5A,NDUFS3,UQCRC1,TXNRD2,COX15,MAOA	
Tetrapyrrole Biosynthesis II	2.71E00	NaN	8.00E-01	UROS,ALAS2,ALAD,HMBS	
Clathrin-mediated Endocytosis Signaling	2.77E00	NaN	2.27E-01	APOE,SH3BP4,APOB,FGF2,CLTB,SH3GLB1,AP1B1,AP2A2,RAB5A,LYZ,AMPH,VEGFD,DAB2,S100A8,SH3GLB2,ACTG2,CSNK2B,LDLRAP1,PIK3R2,HGS,ACTA1,RAB4B,PIK3C2B,SRC,AP2M1,EPN1,ARPC5L,VEGFC,SAA4,AP2S1,HSPA8,SH3GL1,LDLR,TF,ORM1,PIP5K1C,APOC1,TFRC,ORM2,PDGFD,DNM1L,RBP4	
ILK Signaling	2.77E00	-1.4795908857482156	2.27E-01	BMP2,MYL5,PPP2R3B,MYL6B,HIF1A,MYH11,PPP1R14B,MYC,PARVB,MTOR,JUN,RHOB,RHOD,FLNA,RHOU,VEGFD,ATF4,IRS2,GSK3B,PIK3R2,ACTG2,TESK1,MYL3,ACTA1,ACTN1,MYH1,RND2,PIK3C2B,PARVA,VEGFC,CREB5,FOS,DOCK1,PPP2R1A,FLNC,LIMS1,PTPA,ARHGEF6,RSU1,RPS6KA4,PTGS2,MMP9	
Virus Entry via Endocytic Pathways	2.83E00	NaN	2.70E-01	PIK3C2B,SRC,FYN,AP2M1,ITSN1,CLTB,ABL1,HRAS,AP1B1,AP2A2,AP2S1,ITGA3,CD55,RRAS2,FLNC,FLNA,PRKCD,CAV1,PRKCE,TFRC,ITGA1,ACTG2,PIK3R2,ACTA1	
Aryl Hydrocarbon Receptor Signaling	2.86E00	NaN	2.43E-01	ALDH4A1,NFIX,GSTM5,NQO2,CDK4,IL6,GSTT1,MYC,TGM2,CTSD,NCOA7,ALDH1A1,GSTM2,JUN,CCND3,ALDH1A3,RARA,ALDH3A2,ALDH3A1,ALDH5A1,CHEK2,ALDH1B1,GSTM1,SRC,GSTM3,NQO1,CYP1B1,FOS,CCND2,ALDH1A2,ALDH3B1,HSPB7,GSTO2,ESR1	
Unfolded protein response	2.94E00	NaN	3.15E-01	SCAP,DDIT3,ERN1,HSPA1A/HSPA1B,HSPA9,CEBPD,CANX,ATF6,HSPA5,HSPA2,CEBPG,HSPA8,HSPA4,EDEM1,PPP1R15A,ATF4,AMFR	
Pentose Phosphate Pathway	2.95E00	NaN	6.00E-01	PGD,RPE,TALDO1,PGLS,G6PD,H6PD	
Cholesterol Biosynthesis I	3E00	NaN	5.38E-01	SQLE,DHCR7,DHCR24,MSMO1,LSS,TM7SF2,CYP51A1	
Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)	3E00	NaN	5.38E-01	SQLE,DHCR7,DHCR24,MSMO1,LSS,TM7SF2,CYP51A1	
Cholesterol Biosynthesis III (via Desmosterol)	3E00	NaN	5.38E-01	SQLE,DHCR7,DHCR24,MSMO1,LSS,TM7SF2,CYP51A1	
Integrin Signaling	3.03E00	2.4688535993934706	2.27E-01	FYN,RALA,PFN1,MYL5,ABL1,PPP1CB,HRAS,MYLK,ITGA10,PARVB,SHC1,ITGA3,RHOB,MAP2K2,ITGA11,RHOD,SOS1,RHOU,CAV1,GSK3B,PIK3R2,ACTG2,ACTN1,ACTA1,RND2,CAPN5,PIK3C2B,SRC,PAK4,CAPN6,PARVA,ARPC5L,TNK2,DOCK1,CAPNS1,ARF5,RRAS2,TLN2,ITGAM,WAS,LIMS1,TSPAN1,CAPN2,ITGA1,TSPAN6,NEDD9,ITGA7	
Huntington's Disease Signaling	3.03E00	-0.3333333333333333	2.23E-01	SGK1,HSPA1A/HSPA1B,GNA11,CLTB,HRAS,CASP4,RCOR2,HSPA5,NGF,AP2A2,VTI1B,TGM2,HSPA4,SHC1,CTSD,NSF,MTOR,GNG11,JUN,GNA15,HDAC11,SOS1,ATF4,PRKCE,DLG4,PIK3R2,GNG5,NAPB,POLR2I,CAPN5,PIK3C2B,CAPN6,GNG2,HSPA9,PSME2,POLR2H,CREB5,STX1A,HSPA2,PSME3,GPAA1,TAF9B,GNG10,HSPA8,POLR2G,BCL2L1,CAPNS1,PRKCD,PSME4,CAPN2,DNM1L	
Axonal Guidance Signaling	3.08E00	NaN	2.00E-01	SLIT3,PFN1,BMP4,ITSN1,UNC5B,MYL5,CXCL12,HRAS,MYL6B,TUBB,ITGA3,PLCE1,GNA15,MAP2K2,VEGFD,TUBA1C,PLXNB2,GSK3B,CHMP1A,FZD2,RTN4R,MYL3,WNT5B,PIK3C2B,STK36,ADAMTS1,TUBB2A,GNG2,VEGFC,MMP2,FZD9,GNAZ,GNG10,DOCK1,SRGAP3,SDCBP,PRKCD,ARHGEF6,RTN4,FZD5,PDGFD,NRP1,--,ERAP2,FYN,ADAM17,ADAMTS7,PLXNA3,BMP2,GNA11,SEMA6A,ABL1,NGF,TUBB2B,EPHB6,EFNB2,SHC1,GNG11,RHOD,SRGAP1,SOS1,SMO,PRKCE,PSMD14,ERBB2,SEMA3B,RASSF5,PIK3R2,GNG5,PLXNA1,SEMA3G,PAK4,ARPC5L,CXCR4,C9orf3,TUBG1,GNAI1,SLIT2,RRAS2,KIF7,NTRK3,WAS,EPHB3,SEMA3C,BMP6,MMP9,FZD7	
Oxidative Ethanol Degradation III	3.2E00	NaN	4.74E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,ALDH1A3,ALDH3A2,ALDH1A2,ALDH3B1,ALDH3A1	
Atherosclerosis Signaling	3.2E00	NaN	2.58E-01	APOE,APOB,CD36,CXCL12,IL6,TNFRSF12A,COL1A2,LYZ,CCL2,PLA2G5,S100A8,COL18A1,CXCL8,VCAM1,SELE,CXCR4,SAA4,TNFRSF14,PLA2G2A,TPSAB1/TPSB2,GLG1,COL1A1,PLA2G4A,COL5A3,ORM1,APOC1,RARRES3,ORM2,PDGFD,MMP9,COL3A1,RBP4	
Heme Biosynthesis II	3.29E00	NaN	6.67E-01	PPOX,UROS,FECH,ALAS2,ALAD,HMBS	
Pentose Phosphate Pathway (Oxidative Branch)	3.36E00	NaN	1.00E00	PGD,PGLS,G6PD,H6PD	
IL-8 Signaling	3.37E00	1.6774842736586515	2.39E-01	HRAS,IRAK1,EIF4EBP1,HMOX1,IKBKG,MTOR,GNG11,JUN,RHOB,CCND3,MAP2K2,RHOD,RHOU,VEGFD,PRKCE,PIK3R2,GNG5,TEK,RND2,PIK3C2B,CXCL8,SRC,NOX4,VCAM1,PLD3,ANGPT1,GNG2,GNAI1,HBEGF,VEGFC,MMP2,CSTB,GNG10,FOS,BCL2L1,RRAS2,ITGAM,CCND2,PRKCD,NCF2,PTGS2,KDR,MAP4K4,MMP9	
Retinoate Biosynthesis I	3.41E00	NaN	3.94E-01	DHRS3,ALDH1A1,DHRS9,AKR1C3,ALDH1A3,BMP2,ALDH1A2,ADH1C,RDH5,RBP5,AKR1C4,AKR1B10,DHRS4	
Dopamine Degradation	3.59E00	NaN	4.29E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,SMOX,ALDH1A3,COMT,ALDH3A2,ALDH1A2,ALDH3B1,ALDH3A1,MAOA	
Superpathway of Cholesterol Biosynthesis	3.59E00	NaN	4.29E-01	MVD,SQLE,DHCR7,ACAT2,DHCR24,ACAT1,MSMO1,LSS,TM7SF2,HMGCS1,CYP51A1,HADHA	
Ethanol Degradation II	3.71E00	NaN	4.00E-01	ALDH4A1,ALDH1B1,ADH1C,ALDH2,ALDH1A1,DHRS9,ALDH1A3,ALDH3A2,ALDH1A2,PECR,ALDH3B1,ALDH3A1,ADHFE1,DHRS4	
Fatty Acid α-oxidation	3.74E00	NaN	5.00E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,ALDH1A3,ALDH3A2,ALDH1A2,ALDH3B1,PTGS2,ALDH3A1	
Tryptophan Degradation X (Mammalian, via Tryptamine)	3.85E00	NaN	4.78E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,SMOX,ALDH1A3,ALDH3A2,ALDH1A2,ALDH3B1,ALDH3A1,MAOA	
Complement System	4.01E00	0.9045340337332909	4.05E-01	CD59,C4BPB,C5AR1,MASP1,C1QC,C1QA,C1QB,C1R,CD55,ITGAM,C7,CFB,C1QBP,C6,C2	
Putrescine Degradation III	4.31E00	NaN	5.24E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,SMOX,ALDH1A3,ALDH3A2,ALDH1A2,ALDH3B1,ALDH3A1,MAOA	
Histamine Degradation	4.54E00	NaN	5.88E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,HNMT,ALDH1A3,ALDH3A2,ALDH1A2,ALDH3B1,ALDH3A1	
Ethanol Degradation IV	4.63E00	NaN	5.22E-01	ALDH2,ALDH1B1,ALDH4A1,ALDH1A1,ALDH1A3,ALDH3A2,CAT,ALDH1A2,CYGB,ALDH3B1,ALDH3A1,GPX7	
Noradrenaline and Adrenaline Degradation	5.16E00	NaN	4.47E-01	ALDH4A1,ALDH1B1,ADH1C,ALDH2,ALDH1A1,DHRS9,SMOX,ALDH1A3,ALDH3A2,COMT,ALDH1A2,PECR,ALDH3B1,ALDH3A1,ADHFE1,MAOA,DHRS4	
NRF2-mediated Oxidative Stress Response	6.78E00	3.181980515339464	2.94E-01	DNAJB4,MAF,HRAS,DNAJC15,DNAJB2,CLPP,GSTM2,MAP2K2,ABCC1,KEAP1,DNAJA3,ATF4,GCLM,TXN,GSK3B,ACTG2,ACTA1,PIK3C2B,GSTM3,JUNB,TXNRD1,GSR,ERP29,PRKCD,STIP1,MAP2K3,SQSTM1,DNAJB6,MAPK7,HACD3,MAP2K5,FTH1,EPHX1,GSTM5,NQO2,GSTT1,MAFG,HMOX1,JUN,DNAJC4,PRKCE,FMO1,PIK3R2,GSTM1,NQO1,DNAJC1,FOS,RRAS2,DNAJB11,CAT,AOX1,CDC34,GSTO2	
Hepatic Fibrosis / Hepatic Stellate Cell Activation	6.92E00	NaN	2.95E-01	CTGF,MYL5,KLF6,COL8A1,MYL6B,IL6,TGFBR2,VEGFD,MYL3,CXCL8,VEGFC,BAMBI,MMP2,IFNAR2,COL6A3,IL10RA,IGFBP3,CD14,PDGFD,COL3A1,COL7A1,IGFBP4,COL4A5,LEP,FGF2,LEPR,MYH11,COL15A1,COL6A6,COL5A1,COL16A1,COL1A2,COL6A1,CCL2,EDN1,TIMP1,COL22A1,LBP,COL18A1,MYH1,AGT,COL5A2,VCAM1,COL6A2,COL12A1,SMAD7,IL18RAP,COL1A1,LY96,COL5A3,EDNRA,COL11A1,KDR,MMP9	
tRNA Charging	9.8E00	NaN	5.90E-01	CARS,GARS,HARS,HARS2,TARS,MARS,EPRS,FARSA,WARS2,NARS,WARS,LARS,TARS2,FARS2,YARS,VARS2,EARS2,AARS2,AARS,SARS2,SARS,VARS,IARS	

Upstream Regulators for My Projects->David Bulger->P1
Analysis	ID	Upstream Regulator	Expr Log Ratio	Molecule Type	Predicted Activation State	Activation z-score	Notes	Bias Term	Bias-corrected z-score	p-value of overlap	Target molecules in dataset	Mechanistic Network	
P1	 	beta-estradiol	 	chemical - endogenous mammalian	Activated	3.230	 	0.183	-0.112	2.03E-38	AARS,ABCA3,ABHD5,ACADM,ACADVL,ACKR2,ACP5,ACTA1,ADAMTS1,ADCY1,ADGRG2,ADH1C,ADIPOQ,ADM,ADM2,ADORA1,ADRB2,AEBP1,AES,AGT,ALCAM,ALDH1A2,ALDH4A1,ALDOA,ANGPT1,ANO2,ANXA3,AP1B1,AP3D1,APCDD1,APOE,ARF5,ARID4A,ASB1,ATF3,ATF5,ATP2B1,ATP5I,ATP6V1F,BACE2,BCL2L1,BEX2,BIN1,BIRC3,BMP2,BMP4,BNIP3L,BOP1,BSG,BTG1,BTG2,BYSL,C1QTNF6,CA12,CASP4,CAST,CAV1,CBX6,CCDC170,CCDC80,CCL2,CCND2,CCND3,CCNG2,CCR1,CD14,CD24,CD276,CD55,CD69,CD86,CDC20,CDH2,CDKN1C,CDKN2B,CFB,CLCN3,CLSTN2,CNN1,CNN2,COCH,COL1A1,COL1A2,COL3A1,COL4A5,COL6A6,COLEC12,COMP,COMT,CPXM1,CRABP2,CSE1L,CSF3R,CSTB,CTGF,CTPS1,CTSB,CTSD,CTSH,CTSK,CUBN,CXCL12,CXCL2,CXCL8,CXCR4,CYB5A,CYP1B1,CYP26B1,CYP4B1,CYP51A1,CYR61,CYTH3,DCLK1,DDIT3,DDIT4,DDOST,DEFB1,DGUOK,DHCR7,DHRS9,DLG4,DNAJC1,DNPH1,DPM2,DUSP1,DUSP10,EDN1,EFNB2,EGR1,EGR2,EGR3,EIF3B,EMG1,EMP1,ENO1,ENPP2,EPAS1,EPB41L3,ERBB2,ESR1,ETS1,FAAH,FADS3,FAM162A,FARSA,FCGRT,FGF2,FHL1,FLOT1,FMO1,FMO2,FNDC5,FOS,FOSB,FOXC1,FST,FUCA1,FZD2,G6PD,GADD45A,GADD45B,GARS,GCSH,GFM1,GJB2,GM2A,GNL3,GPAM,GPC1,GPX3,GSK3B,GSR,GSTM3,GTF2IRD1,GUCY1A3,H19,H6PD,HBEGF,HCST,HDAC11,HDGF,HES6,HIST2H2AA3/HIST2H2AA4,HLA-DRB1,HMGCS1,HMOX1,HNRNPK,HOXA9,HRAS,HSD11B2,HSD17B11,HSPA2,HSPA4,HSPA5,HSPA8,HSPA9,IARS,ID1,ID4,IDO1,IER2,IER3,IFRD1,IFT122,IGF2R,IGFBP3,IGFBP4,IGFBP6,IGSF1,IKBKG,IL6,IMPDH2,INHBB,IP6K1,IP6K3,IPO4,IRS2,IRX5,ITGA1,JUN,JUNB,KCNAB1,KDELR3,KDR,KIAA0922,KIT,KLF2,KLF4,KLF6,KLF9,KPNA2,KRT8,LAGE3,LDLR,LEP,LEPR,LHCGR,LHFPL2,LILRB5,LIMA1,LITAF,LMCD1,LMNA,LOC102724428/SIK1,LPIN1,LRP8,LUM,LYZ,MAL2,MAOA,MAP3K8,MATN2,MBP,MCM2,MGP,MMD,MME,MMP2,MMP9,MSMO1,MYC,MYLK,MYOF,NARS,NCF2,NDRG1,NEDD4L,NEDD9,NET1,NFKBIA,NHP2,NIPSNAP1,NME1,NPR3,NR4A3,NR5A2,NRP1,NTRK3,NUCB2,NUPR1,ODC1,OGN,OSBPL7,PA2G4,PADI4,PAQR7,PCBD1,PDCD4,PDE3B,PDK4,PFKL,PHLDA1,PIK3C2B,PIK3R2,PKM,PLA2G4A,PLAA,PLAT,PLAUR,PLIN2,PMP22,PNRC2,POMC,PPP1R3C,PPRC1,PRKCD,PRSS23,PSAT1,PSMB2,PTGDS,PTGFR,PTGIS,PTGS2,PTPRK,PTTG1,PTX3,PYCR1,QSOX1,RALA,RAMP3,RAN,RAP1GAP,RARA,RASGRP2,RBBP8,RBPMS,RCL1,RER1,RERG,RET,RGS1,RPN2,RUNX1,S1PR1,SAA1,SBF1,SDC4,SELE,SEMA3B,SEMA3C,SERPINA3,SERTAD4,SFRP1,SFRP2,SFRP4,SFXN5,SGK1,SHC1,SIAH2,SLC12A2,SLC20A1,SLC22A5,SLC24A3,SLC25A15,SLC2A3,SLC3A2,SLC6A9,SLC7A2,SLC7A5,SLC7A8,SLC9A1,SLCO2B1,SLIT2,SLK,SMAD6,SMPD1,SMPDL3A,SOCS2,SOCS3,SORD,SOS1,SOX9,SPARC,SPRY1,SPRY2,SQLE,SQSTM1,SRC,SRD5A1,ST6GALNAC4,STC1,STC2,STIP1,STON1,STXBP1,SUCLA2,SUSD2,SYT11,TARS,TESK1,TF,TFPI2,TGFBR2,TGFBR3,THBD,THBS1,THBS4,THRA,THRSP,TIMP1,TJP1,TM4SF1,TMED9,TMEM2,TMEM37,TMIE,TNFAIP3,TPM1,TPO,TRIB1,TRIM29,TRO,TSC22D1,TUBG1,TXN,TXNRD1,VAMP1,VAPA,VAV3,VCAM1,VCAN,VHL,WNT5B,YARS,ZBTB9,ZFP36,ZFP36L2,ZNF75D,ZNF91	ESR1,ESR2,FOS,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1,TNF,beta-estradiol	
P1	 	TNF	-0.288	cytokine	 	0.008	 	0.182	-3.306	2.89E-35	ABCC1,ABCC3,ABR,ACACA,ACADM,ACADVL,ACKR2,ACP5,ACTA1,ADAM17,ADAMTS7,ADIPOQ,ADM,ADORA1,ADRB2,AEBP1,AGT,AK2,AKAP12,AKR1B1,AKR1B10,ALAD,ALCAM,ALDH1A3,ALDH2,ALDH3A1,ANGPT1,ANGPTL4,AOC3,APBA3,APOE,AQP9,ASGR1,ASS1,ATF3,ATF4,ATP2A2,ATP2B1,AXIN1,AXIN2,BAMBI,BCL2L1,BHLHE41,BIRC3,BIRC7,BMP2,BMP4,BMPER,BTG1,BTG2,BTG3,C1QTNF1,C21orf33/LOC102724023,C5AR1,CARD8,CASP4,CAT,CAV1,CBR3,CCDC80,CCL13,CCL18,CCL2,CCL3,CCL3L3,CCND2,CCND3,CCR1,CD14,CD163,CD163L1,CD1C,CD209,CD36,CD4,CD55,CD59,CD69,CD86,CDH2,CDH5,CDK4,CDKN2C,CDO1,CEBPD,CEBPG,CFB,CH25H,CHI3L2,CIDEC,CNN1,COL15A1,COL16A1,COL1A1,COL1A2,COL3A1,CPA3,CSF1R,CTGF,CTSB,CTSK,CXCL12,CXCL16,CXCL2,CXCL8,CXCR4,CYBA,CYP11A1,CYP1B1,CYP26B1,CYP27A1,CYP2C8,CYR61,CYTH3,CYTIP,CYYR1,DCHS1,DDIT3,DHRS3,DLEU1,DUSP1,DUSP10,DUSP14,DUSP5,EDN1,EFNB2,EGR1,EGR2,ELK1,EMP1,ENPP2,ERBB2,ERCC1,ESR1,ETS1,ETV5,EXOSC7,F11R,FBL,FCER1G,FCER2,FCGRT,FGF2,FMO1,FOS,FOSB,FRZB,FSCN1,FST,FTH1,FYN,FZD5,G0S2,GADD45A,GADD45B,GBP1,GCLM,GDF15,GFPT2,GFRA2,GM2A,GNAI1,GPAM,GRN,GSK3B,GSPT1,GSTM2,GUSB,H19,HBEGF,HCAR3,HDC,HEXA,HIF1A,HIPK2,HLA-DRB4,HLA-F,HMOX1,HOXA9,HP,HSPA1A/HSPA1B,HSPA4,HSPA8,ID1,ID3,IDO1,IER2,IER3,IFI27,IFNAR2,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL17D,IL6,IRS2,ITGA10,ITGAM,ITPR2,JUN,JUNB,KCNJ2,KCTD13,KDR,KIT,KLF2,KLF4,KLF6,LAMP3,LBP,LDLR,LEP,LHCGR,LIPE,LITAF,LOX,LSS,LTBP2,LTBR,LXN,LY96,LYN,LYVE1,MAN1C1,MAP2K3,MAP3K20,MAP3K8,MAP4K4,MAPKAP1,MBP,MCAM,MCL1,MECOM,MEOX2,MGMT,MGP,MIA,MIF,MMD,MMP2,MMP28,MMP9,MSC,MST1,MT1A,MT1L,MYC,MYLK,NAGLU,NCF2,NEDD9,NET1,NFKBIA,NFKBIZ,NGF,NINJ1,NLRP3,NME1,NNMT,NOTCH1,NPM3,NQO1,NR4A2,NR4A3,NR5A2,NRP1,NUCB2,ODC1,OGN,OLFML2B,ORM1,OSBPL10,PC,PCBP2,PCDH7,PCK2,PDE8B,PDZD2,PHLDA1,PLA2G2A,PLA2G4A,PLA2G5,PLAA,PLAT,PLAUR,PLD3,PLIN1,PLIN2,PLXNB2,POMC,PPP1R15A,PPP1R3C,PRKCD,PRNP,PRSS23,PSMB10,PSME2,PTGFR,PTGS2,PTX3,RAB32,RAPGEF5,RARA,RARRES2,RARRES3,RASD1,RBPMS,RCAN1,RCAN2,RCN3,RGCC,RGS1,RGS16,RGS20,RGS5,RNASE1,RNASE4,RNF125,RRM2B,S100A8,S100A9,S1PR3,SAA1,SAMD4A,SCUBE2,SDC4,SELE,SEMA3C,SERPINA3,SERPINE2,SFRP1,SGK1,SLC11A1,SLC16A2,SLC16A5,SLC1A3,SLC1A4,SLC20A1,SLC27A1,SLC35B2,SLC7A1,SLC7A2,SLC7A8,SLCO2B1,SMAD7,SMPD1,SMPDL3A,SNRK,SOCS2,SOCS3,SORBS1,SOX9,SPARC,SPP1,SQLE,SQSTM1,ST3GAL3,ST3GAL6,TAGLN,TALDO1,TBC1D8,TEK,TF,TFPI2,TFRC,TGFBR2,TGM2,THBD,THBS1,THRSP,THY1,TIMP1,TIMP4,TJP1,TM4SF1,TNFAIP3,TNFAIP8,TNFRSF10B,TNFRSF21,TNFRSF4,TNFSF10,TNIP1,TPO,TPTEP1,TUB,TUSC5,TXN,TXNRD1,TYMP,UCP2,UTP11,VAV3,VCAM1,VEGFC,VEGFD,WBSCR22,ZFP36,ZNF330	Ap1,IFNG,IKBKB,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF	
P1	 	TGFB1	0.032	growth factor	 	-0.006	 	0.172	-2.828	2.73E-32	ABCF1,ABCG1,ABL1,ACKR2,ACLY,ACSL3,ACTA1,ACTG2,ACTN1,ADAM17,ADGRG2,ADIPOQ,ADM,ADORA1,ADRA2A,AHNAK,AK1,ALDH2,ALDH3A2,ALDH5A1,ANGPT1,ANGPTL4,APLNR,APOB,APOE,AQP11,AQP9,ASNS,ASS1,ATF4,ATG7,AXL,BAMBI,BCL2L1,BIN1,BMF,BMP2,BMP4,BMP6,BNIP3L,BSG,BTG1,BUD31,C1QA,C1QB,C1QC,C2,C21orf33/LOC102724023,C5AR1,C9orf3,CAPNS1,CAPRIN1,CARS,CASP4,CAT,CAV1,CBR3,CCL2,CCL3,CCL3L3,CCND2,CCND3,CCNG2,CCR1,CCT5,CD14,CD163,CD36,CD4,CD55,CD59,CD68,CD69,CD86,CDC20,CDH2,CDH5,CDK4,CDKN1C,CDKN2B,CDKN2C,CELF2,CIDEC,CNN1,CNN2,COL11A1,COL12A1,COL16A1,COL18A1,COL1A1,COL1A2,COL3A1,COL5A1,COL6A1,COL6A2,COL6A3,COL7A1,COL8A1,COMP,CPXM1,CSF1R,CSPG4,CST3,CTGF,CTPS1,CTSB,CTSD,CTSH,CTSK,CXCL12,CXCL2,CXCL8,CXCR4,CYB561,CYBA,CYC1,CYP11A1,CYR61,DAAM1,DAB2,DDIT4,DFNA5,DKC1,DKK3,DNAJB4,DNAJB6,DNPEP,DSG2,DUSP1,EDN1,EDNRA,EGR1,EGR2,EGR3,ELN,EMILIN1,EPRS,ESAM,ETS1,F13A1,FAM107A,FAM110B,FAM53B,FCER1A,FCER1G,FCGR3A/FCGR3B,FGF2,FHL1,FLNA,FLRT1,FNDC5,FOS,FOSB,FOXC1,FSCN1,FTH1,FYN,FZD2,GADD45A,GADD45B,GALM,GARS,GBP1,GDF15,GDPD5,GFPT2,GJB2,GLRX2,GNAZ,GNG2,GPR146,GUSB,H6PD,HBEGF,HCAR2,HCST,HDGF,HEXA,HEY1,HIF1A,HINT1,HMGA1,HMOX1,HNMT,HNRNPH1,HSPA1A/HSPA1B,HSPA5,IARS,ID1,ID3,ID4,IER2,IER3,IFI27,IFRD1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL17D,IL6,ING1,INHBB,IRF3,ITGA1,ITGA11,ITGA3,ITGA7,ITGAM,ITPK1,ITPR2,JUN,JUNB,KCNG1,KDELR3,KDR,KIT,KLF2,KLF4,KLF9,KRT8,LDLR,LEP,LHCGR,LIMS1,LITAF,LOC102724788/PRODH,LOX,LPAR1,LRBA,LTBP2,LYVE1,MAF,MAOA,MAP2K3,MAPK7,MAPK8IP3,MAPKAPK2,MCM2,MFAP2,MFAP4,MGMT,MGP,MMP2,MMP9,MS4A2,MSMO1,MTHFD2,MVD,MYC,MYCN,MYH11,MYL3,MYLK,MYO10,MYOF,NAB1,NBEA,NCF2,NEDD9,NET1,NFKBIA,NGF,NIPA2,NLRP3,NME1,NMNAT2,NNMT,NOC3L,NOTCH1,NOX4,NPAS2,NPTXR,NR4A2,NR4A3,NRBP1,NRP1,NUCB2,NUPR1,OLFM2,P2RX6,PA2G4,PARP3,PCCB,PCOLCE2,PDCD4,PDLIM7,PHLDA2,PLA2G4A,PLAT,PLAUR,PLOD1,PLS3,PMEPA1,POLD1,POMC,PPFIBP2,PPP1R1B,PPP1R3C,PSME4,PTGDS,PTGER4,PTGS2,PTPRK,RAD21,RAMP2,RARA,RBPMS,RGCC,RHOB,RHOD,RHOU,RNH1,ROR1,RPN2,RSU1,RUNX1,S1PR3,SDC4,SDPR,SELE,SEMA3B,SERPINA3,SERPINE2,SERPINH1,SERTAD1,SFRP1,SGK1,SGSH,SLC20A1,SLC22A18,SLC2A3,SLC39A8,SLC4A2,SLC52A2,SLC7A1,SLC7A5,SLIT3,SMAD6,SMAD7,SMOC2,SOCS3,SOX9,SPARC,SPI1,SPP1,SPRY1,SRC,SRM,SRSF3,STC2,STOML2,SVEP1,TACC2,TAGLN,TAX1BP3,TENM4,TFRC,TGFBR2,TGFBR3,TGM2,THBD,THBS1,THY1,TIMP1,TJP2,TNFAIP3,TNFRSF12A,TNFRSF14,TPM1,TPSAB1/TPSB2,TPST2,TSC22D1,TTLL3,TUBB2A,TUFM,TXNRD1,TYMP,VAT1,VCAM1,VCAN,VEGFC,VPS28,WNT5B,XPNPEP2,ZFP36,ZFP36L2,ZFPM2	Ap1,EGR1,ESR1,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TNF,TP53,Tgf beta	
P1	 	dexamethasone	 	chemical drug	Inhibited	-2.810	 	0.093	-4.490	4.49E-32	ABCC1,ABCC3,ACACA,ACADM,ACAT1,ACTG2,ADAM17,ADAMTS1,ADCK4,ADHFE1,ADIPOQ,ADM,ADRA2A,ADRB2,AEBP1,AGT,AKAP12,AKR1C3,AKR1C4,ALCAM,ALDH1A1,ALDH1B1,ALDH4A1,ANGPTL4,ANK2,ANO1,ANOS1,APOE,ARG2,ARHGAP17,ARHGDIA,ARHGEF2,ASNS,ASPH,ATF4,ATN1,ATP2A2,ATP2B1,ATP6V1B2,AUP1,AXIN2,B4GALT2,BCAT2,BCKDK,BCL2L1,BIRC3,BMP2,BSG,BTG1,BTG2,BZW2,C1QB,C5AR1,CANX,CARS,CAT,CAV1,CBR3,CCL18,CCL2,CCL3,CCL3L3,CCND2,CCND3,CCNG2,CCR1,CD163,CD1C,CD209,CD36,CD55,CD59,CD69,CD86,CDK4,CDKN1C,CDKN2B,CEBPD,CELF2,CES1,CES2,CFB,CLDN5,CMKLR1,CNN2,COL11A1,COL15A1,COL1A1,COL4A5,COL6A1,COL6A2,COL7A1,CPA4,CPSF3,CRABP2,CRHBP,CRIP1,CRISPLD2,CSF1R,CST3,CTGF,CTSB,CTSD,CTSK,CXCL12,CXCL14,CXCL2,CXCL8,CXCR4,CYP11A1,CYP1B1,CYP27A1,CYP2C8,CYP51A1,CYR61,DAP3,DDIT3,DDIT4,DEFB1,DHCR24,DNAJC15,DNM1L,DPAGT1,DUSP1,DUSP10,DUSP5,EDEM1,EDN1,EDNRA,EGR1,EGR2,EGR3,EIF5,EIF6,ELK1,ELN,ELOVL3,ELOVL6,EPAS1,EPB41L4B,ETV5,EYA2,FAM107A,FAM129A,FANCE,FBN2,FGF2,FKBP2,FKBP4,FLRT2,FMO1,FOS,FOSB,FST,FTH1,G0S2,G6PD,GADD45A,GADD45B,GAP43,GAPDH,GBP1,GCAT,GCLM,GDF15,GKN1,GLUL,GNG10,GOT1,GPC3,GRK5,GRN,GSTM1,GSTM3,GSTM5,H6PD,HARS,HBEGF,HCST,HLA-DRB1,HMGA1,HMOX1,HNRNPH1,HOMER2,HP,HSD11B2,HSD17B11,HSPA5,HSPA8,ID1,IDO1,IER2,IER3,IFNAR2,IFRD1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL6,INHBB,IP6K3,IRAK1,IRF3,IRS2,ISG20,ITGA10,ITGAM,ITPR2,IVD,JUN,JUNB,KAT2A,KCNK3,KDR,KIT,KLF9,KPNA2,KRT8,LAGE3,LAMA2,LBP,LDLR,LEP,LIPE,LITAF,LMO4,LPAR1,LPIN1,LPIN2,LRP8,LRRK2,LSP1,LSS,LTBP2,LY6E,LYN,LYVE1,MAF,MAOA,MAPK7,MARCO,MBD2,MBP,MCL1,ME1,MFAP5,MGMT,MGP,MIA,MID1IP1,MIF,MME,MMP2,MMP9,MPPE1,MT1G,MT1L,MT1M,MT1X,MTOR,MXRA5,MYC,MYCN,MYOC,NAGK,NEDD4L,NET1,NEU1,NFE2L1,NFKBIA,NFKBIZ,NGF,NIPSNAP1,NPM3,NPR3,NR2F6,NREP,NUCB2,ODC1,OLFML2B,ORM1,P2RX7,P4HA2,P4HTM,PC,PCBD1,PCDH9,PCK2,PCSK5,PDCD4,PDK4,PEBP1,PFKFB3,PHLDA1,PHLDA2,PLAT,PLEC,PLIN1,PLOD1,PLOD3,PLSCR4,PNRC2,POMC,POMGNT1,PRAG1,PRELP,PTGDS,PTGS2,PTX3,RARA,RARRES3,RASD1,RBP4,RCAN1,RDH5,RET,RGCC,RGN,RGS1,RGS5,ROR1,RPLP0,S100A8,S100A9,S100P,SAA1,SAA2,SAA4,SDPR,SEC61A1,SELE,SERPINA3,SERPINE2,SFRP1,SGK1,SHC1,SLC25A1,SLC2A3,SLC2A5,SLC2A8,SLC4A7,SLC7A6,SLC9A1,SLCO2A1,SLCO2B1,SMOC2,SOCS2,SOCS3,SOX9,SPARC,SPOCD1,SPP1,SPRY1,SPTBN1,SRGN,SRM,SRPRA,ST3GAL4,STOM,STON1,STX1A,SULF2,TAF6,TAGLN,TBC1D10B,TF,TFPI2,TGFBR2,TGFBR3,TGM2,THBD,THBS1,THRSP,TIMP1,TIMP4,TJP1,TMEM97,TNFAIP3,TNFRSF10B,TNFRSF19,TNFRSF21,TNFSF10,TNS1,TPM1,TPR,TSC22D1,TXN,UCP2,VARS,VCAM1,VCAN,VEGFC,WARS,ZFP36,ZFP36L2,ZFPM1,ZNF91	Ap1,IFNG,IL1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TNF,dexamethasone	
P1	 	TP53	0.253	transcription regulator	 	0.669	 	0.106	-1.032	6.22E-32	ABCC1,ABHD4,ACADVL,ACAT1,ACLY,ACO2,ACP2,ACSL3,ACTN1,ADRB2,AEN,AHCY,AHSA1,AK1,AKAP12,AKR1B1,ALDH1A2,ALDH4A1,ANGPT1,ANTXR1,ANXA3,AP1B1,APOE,ARHGEF2,ASNS,ASS1,ASTN2,ATF3,ATF4,ATG7,AXIN2,BAP1,BCL2L1,BHLHE41,BIRC3,BMF,BTG1,BTG2,C1QC,C2,CAMK2D,CAPNS1,CARS,CASP4,CAT,CAV1,CCDC80,CCL2,CCL3L3,CCNB1IP1,CCND2,CCND3,CCNG2,CCNL1,CD59,CDC16,CDC20,CDK4,CEL,CEP164,CEP170B,CERS6,CES2,CHEK2,CLPP,CNN1,CNN2,COL18A1,COL1A1,COL1A2,COL3A1,COL5A2,COL6A2,COMT,COQ8A,CSF1R,CSF2RA,CSF3R,CSK,CSTB,CTGF,CTSB,CTSD,CTSH,CTSK,CXCL12,CXCL8,CYB5A,CYP51A1,CYR61,DBP,DDIT3,DDIT4,DDIT4L,DDX3X,DGCR6/LOC102724770,DHCR24,DHCR7,DHRS9,DKK3,DNM1L,DUSP1,DUSP5,EDN1,EGFL6,EGR1,EGR2,EGR3,EIF4E2,EMILIN1,ENPP2,EPHX1,ERBB2,ERCC1,ESR1,F11R,FAT1,FGF2,FHL1,FKBP1A,FKBP4,FLRT2,FMO1,FOS,FRMD4A,FUCA1,FYN,G6PD,GADD45A,GAPDH,GBP1,GDF15,GLB1,GLRX,GLUL,GNAI1,GNL3,GPX3,GSK3B,GSR,GSTM1,GSTM5,H19,H2AFY2,H2AFZ,HADHA,HBEGF,HDC,HIF1A,HMGCS1,HMOX1,HRAS,HSPA1A/HSPA1B,HSPA8,HSPB7,HYAL1,ID1,ID3,IDH1,IER3,IGFBP3,IGFBP4,IL10RA,IL6,IPO9,JUN,JUNB,KANK3,KAT2B,KCNG1,KCNMA1,KDR,KIAA0368,KIT,KLF4,KPNA2,KRT8,LIMA1,LMO3,LOC102724788/PRODH,LOX,LPIN1,LPP,LSP1,LSS,LYZ,MAP2K2,MAP3K8,MAPRE3,MCAM,MCL1,MCM2,ME1,ME2,MFAP2,MGMT,MICALL1,MLF2,MMP2,MMP23B,MMP9,MOCOS,MPZL2,MSRB1,MST1,MT1L,MVD,MYC,MYO10,MYOF,NAB1,NAP1L4,NARS,NDRG1,NEO1,NFKBIA,NID2,NINJ1,NLRX1,NME1,NOL3,NOTCH1,NOX4,NRP1,NUPR1,NUSAP1,ORM1,ORM2,OSGIN1,P2RX4,PADI4,PANK1,PARP2,PARVA,PAWR,PCDH7,PDIA5,PEG10,PERP,PFKFB3,PFN1,PHKG1,PHLDA1,PHLDA3,PIDD1,PLAUR,PLTP,PLXNB2,PMEPA1,POLD1,POLD2,POLR3E,POMZP3,PPP1R15A,PPP4C,PRKCE,PRNP,PRPSAP1,PSME3,PTGDS,PTGS2,PTPRA,PTPRE,PTTG1,RAD23A,RARRES3,RGS12,RGS16,RHOB,RNASE4,RNF144B,RPN2,RPS27L,RRM2B,RTKN,RUNX1,SEC61A1,SEMA3C,SEMA6A,SERPINA3,SERPINE2,SERPINH1,SESN2,SFRP1,SFRP2,SGK1,SGPL1,SH3BP4,SHC1,SLC19A1,SMAD6,SMAD7,SMARCB1,SNRK,SOCS2,SORBS1,SPATA18,SPHK2,SPP1,SPTLC2,SQLE,SRC,SRSF3,STIP1,SYN1,TACC2,TCTN1,TFPI2,TGFBR2,TGM2,THBD,THBS1,THOP1,THY1,TIMM44,TINAGL1,TJP1,TMEM127,TMEM97,TNFAIP8,TNFRSF10B,TNFSF10,TOB1,TPP1,TRAP1,TRIB3,TRIM28,TRIM6,TSC2,TSPAN6,TUBB,UBA1,UNC5B,UNG,UPP1,UVRAG,VAPA,VCAN,WNT5B,WSB2,XAF1,XPNPEP1,ZFP36,ZMAT3,ZNF84	Akt,Ap1,FOS,HIF1A,Hdac,IFNG,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TNF,TP53,TP63,TP73,YBX1	
P1	 	ERBB2	0.877	kinase	 	0.098	 	0.238	-2.265	6.89E-26	ABHD5,ABL1,ACSL4,ACTA1,ADAM17,ADIPOR2,AHNAK,ALAD,ALDOC,ANG,ANGPTL4,ARHGEF5,ATF4,BCAT2,BCL2L1,BEX2,BIRC3,BTG2,C4BPB,CCDC80,CCND2,CCND3,CD36,CD59,CDC20,CDH2,CDKN2B,CDKN2C,CES1,CHCHD10,CIDEC,CLEC3B,COL18A1,COL1A1,COL3A1,COL5A1,COL5A2,COL6A1,COL6A2,COL6A3,COL7A1,CRIP1,CSF1R,CTGF,CTSB,CXCL12,CXCL8,CYB561,CYP4B1,DAAM1,DDIT3,DNAJB6,DPT,DSG2,EDN1,EGR1,EIF4EBP1,EIF6,ELK1,EMP1,EMP3,ERBB2,ESR1,ETV5,ETV6,FAM134B,FOS,FSCN1,GBE1,GNAI1,GPAA1,GPAM,GPC1,GPX3,GSK3B,GTF3A,GZMH,H19,H6PD,HBEGF,HIF1A,HNRNPK,HOMER2,HP,HSD17B11,HSPA1A/HSPA1B,ID1,IDH1,IGF2R,IGFBP3,IGFBP4,IGFBP6,IL6,IRX3,ITPR2,JCHAIN,JUN,JUNB,KDR,KIT,KLF4,KLHDC3,LAMP2,LITAF,LTBP2,LUM,LXN,MAOA,MAP1B,MAP2K3,MAPK8IP3,MFAP2,MIF,MKNK2,MME,MMP9,MYC,MYCN,MYO10,NDRG1,NDUFAB1,NDUFV1,NEDD9,NET1,NNMT,NOTCH1,NOX4,NPTX2,NRBP1,NRP1,NUCB2,P4HA2,PCK2,PDCD4,PDGFD,PDK4,PFKFB3,PHLDA2,PIN1,PLAT,PLAUR,PMEPA1,POLD1,PTGS2,PTPRB,PTPRK,RAB34,RHOB,RHOD,RNA28S5,S100P,SDPR,SEC61A1,SERPINA3,SERPINI1,SFRP1,SLC4A7,SMAD7,SOCS2,SORBS1,SOWAHC,SPARC,SPINT2,SQLE,SRC,SRPX,ST3GAL4,ST3GAL6,TAGLN,TAX1BP3,TCEAL9,THBD,THBS1,THBS4,THY1,TJP1,TNFRSF10B,TPM1,TSC22D1,UQCR10,VCAN,VEGFC,VEGFD,WNT5B,WSB2,ZFP36L2	ATF2,Akt,EGF,EGFR,ERBB2,ERBB4,HIF1A,JUN,MYC,NFkB (complex),SMAD3,SP1,STAT,STAT3,STAT5A,STAT5B,STAT5a/b,TP53,TP73	
P1	 	lipopolysaccharide	 	chemical drug	 	0.440	bias	0.256	-3.999	2.56E-24	ABCC1,ABCC3,ABCG1,ACADM,ACLY,ACP5,ACTA1,ADIPOQ,ADM,ADORA1,ADRA2A,ADRB2,AGT,AK4,ALCAM,ALDH2,ALDH3A1,ANGPTL4,ANK2,ANXA3,ANXA5,APLNR,APOB,APOC1,APOE,ARG2,ASS1,ATF3,ATG7,ATP1A2,ATP2A2,ATP2B1,ATP5G1,ATP6AP1,BAMBI,BCL2L1,BIRC3,BMP2,BMP4,BSG,BTG1,BTK,C5AR1,CAPN2,CASP4,CAV1,CCDC170,CCL18,CCL2,CCL3,CCL3L1,CCL3L3,CCL8,CCND2,CCNG2,CCNL1,CCR1,CD14,CD163,CD163L1,CD209,CD276,CD36,CD4,CD55,CD59,CD69,CD86,CDC42EP2,CDH2,CDH5,CDK4,CEBPD,CFB,CH25H,CLDN5,COL12A1,COL1A1,COL1A2,COL3A1,COL5A1,COL5A2,COL5A3,COL6A1,CRTAP,CSF1R,CSF2RA,CSF3R,CSPG4,CST3,CSTB,CTGF,CTSB,CTSK,CUBN,CXCL12,CXCL14,CXCL16,CXCL2,CXCL8,CXCR4,CYB5A,CYBA,CYP27A1,CYP2C8,CYR61,CYTIP,DDIT3,DDIT4,DDX3X,DEFB1,DHCR24,DKK3,DLG4,DNAJB11,DUSP1,DUSP5,DVL2,EDN1,EFNB2,EGR1,EGR2,EGR3,ELANE,ELK1,ENO1,ENPP2,ERCC1,ERN1,ETS2,ETV5,ETV6,FAAH,FCER1G,FCGRT,FGF2,FOS,FOSB,FSCN1,FST,FTH1,FYN,G0S2,G6PD,GABARAP,GADD45A,GADD45B,GAP43,GBP1,GBP4,GCA,GJB2,GNA15,GPC4,GPR183,GUCY1A3,GZMH,H19,HBEGF,HCAR2,HCAR3,HDC,HDGF,HEY1,HIF1A,HMGA1,HMOX1,HP,HSPA1A/HSPA1B,HSPA5,HSPA8,HYOU1,ID3,IDH1,IDO1,IER3,IFI27,IFIT2,IFRD1,IGFBP3,IGFBP4,IL10RA,IL18RAP,IL20RB,IL6,INHBB,IRAK1,IRF3,ISG20,ITGA3,ITGAM,JCHAIN,JUN,JUNB,KANK1,KDR,KIAA1551,KIT,KLF2,KLF4,KLF6,LAMP3,LBP,LEP,LIMS1,LIPG,LITAF,LPAR1,LPIN2,LRBA,LRRK2,LY96,LYN,LYZ,MAF,MAP2K2,MAP3K8,MAP4K4,MARCO,MCL1,MCTS1,MIF,MME,MMP2,MMP23B,MMP9,MSC,MT2A,MYC,MYCN,MYL3,NCF2,NFIX,NFKBIA,NFKBIZ,NGF,NID2,NLRP3,NNMT,NOTCH1,NQO1,NR4A2,NR4A3,NR5A2,NRP1,NSFL1C,NUPR1,NUSAP1,ODC1,OGN,ORM1,ORM2,P2RX4,PC,PCDH7,PCOLCE,PCOLCE2,PDCD4,PDK4,PELI1,PERP,PFKFB3,PHLDA1,PHLDB2,PLA2G2A,PLA2G5,PLAA,PLAT,PLAUR,PLIN2,POMC,PPP1CB,PPP1R15A,PPP1R16B,PRDX5,PROCR,PSMB10,PSME2,PTGDS,PTGER4,PTGES2,PTGS2,PTPRB,PTX3,RAN,RARA,RARRES3,RCAN1,RGS1,RGS16,RHOB,S100A8,S100A9,S1PR1,S1PR3,SAA1,SAA2,SCUBE2,SDC4,SELE,SEMA3G,SERPINA3,SERPINE2,SERPINH1,SERPINI1,SFTPD,SLC11A1,SLC15A3,SLC16A2,SLC1A5,SLC31A2,SLC39A8,SLC3A2,SLC9A1,SLCO2A1,SMAD7,SOCS2,SOCS3,SPARC,SPI1,SPP1,SPTLC2,STIM1,STX11,STX6,STXBP1,SWAP70,TALDO1,TEK,TF,TFPI2,TFRC,TGM2,THBD,THBS1,THRA,THRSP,THY1,TIMP1,TIMP4,TIPARP,TNFAIP3,TNFRSF4,TNFSF10,TNIP1,TNK2,TRIB1,TSC22D1,TXN,TYMP,TYROBP,UBA1,UBE2I,UCHL1,UCP2,VCAM1,VCAN,VEGFC,VHL,VSIG4,VTI1B,WARS,XAF1,ZFP36,ZFP36L2,ZFPM1	IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TNF,lipopolysaccharide	
P1	 	MYC	-1.625	transcription regulator	Activated	3.551	 	0.197	0.972	1.46E-22	ACACA,ACAT1,ACSL4,ACTA1,ACTN1,ADAMTS1,ADM,AEBP2,AHCY,AIMP2,AK2,AKAP12,ALCAM,ALDOA,ANGPT1,ANXA5,APCDD1,ASNS,ASS1,ATAD3A,ATF4,ATP13A2,ATPIF1,AXIN1,B4GALT7,BCL2L1,BIN1,BMPER,BOP1,C1QBP,C9orf3,CANX,CAPN2,CAPNS1,CAST,CAV1,CBX4,CCND2,CCND3,CCNG2,CCT3,CD69,CD86,CDC20,CDC34,CDH2,CDK4,CDKN2B,CEBPD,CIDEC,CLEC3B,CNFN,COBLL1,COL15A1,COL1A1,COL1A2,COL3A1,COL5A1,COL5A2,COL6A3,COL8A1,COX7A2L,CRABP2,CRIP1,CSPG4,CSTB,CTDSPL,CTSB,CTSD,CXCL8,DDIT3,DDIT4,DDX11,DDX3X,DKC1,DLEU1,DNPH1,DUSP1,DUSP5,EBF1,EDN1,EGR1,EGR2,EIF2S2,EIF4EBP1,ELANE,EMP1,EMX2,ENO1,ERBB2,EVPL,EXOSC7,FAM129A,FARP1,FBL,FBN2,FCGRT,FECH,FLNA,FOS,FRZB,FTH1,G6PD,GAA,GABARAP,GADD45A,GADD45B,GAMT,GAPDH,GBP4,GCLM,GCSH,GDI1,GFPT1,GLG1,GLUL,GM2A,GOT1,GOT2,GPC1,GPC3,GSR,H19,H2AFZ,H3F3A/H3F3B,HIF1A,HMGA1,HMOX1,HNRNPH1,HSD11B2,HSPA9,HSPE1,ID1,ID3,IDH1,IER3,IMPA2,IRX3,ITGA3,ITGAM,JUN,KDR,KLF4,KLF6,LAMP2,LEP,LGMN,LIMA1,LIMS1,LOC102724788/PRODH,LOX,LSM4,LUM,LXN,LYZ,MBP,MCL1,ME2,METAP2,MGP,MIF,MMP9,MRPL12,MYC,MYCN,NARS,NCL,NDRG1,NFKBIA,NGF,NME1,NRP1,ODC1,PAICS,PDCD4,PDLIM7,PEG10,PERP,PFKFB1,PFKFB3,PFKL,PKM,PLAUR,PLS3,PMP22,PNCK,POLD1,POLR2G,PRMT1,PRPH,PSAT1,PYCR1,RARA,RARRES1,RHOB,RPL6,RPL9,RPLP1,RRM2B,RUVBL1,SDCBP,SEPHS2,SERPINE2,SERPINH1,SFRP1,SGK1,SHMT2,SLC11A1,SLC1A5,SLC25A19,SLC2A3,SLC38A1,SLC3A2,SLC7A5,SOX17,SOX9,SPARC,SPP1,SRD5A1,SRM,ST3GAL3,ST3GAL4,SUCLA2,TF,TFRC,TGFBR2,THBS1,THOP1,THY1,TIMM23,TIMP1,TLE1,TMEM97,TNFRSF10B,TNFRSF19,TOB1,TRAP1,TSC2,TXN,TXNRD1,UBE2I,USP36,VARS,VCAM1,VEGFC,VHL,YME1L1,ZFP36,ZFP42	Ap1,EGR1,ESR1,ESR2,FOS,JUN,MAX,MYC,MYCN,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,TP73,beta-estradiol	
P1	 	PDGF BB	 	complex	Inhibited	-3.189	bias	0.299	-6.075	4.41E-22	ACAT2,ADM,ADRB2,AKAP12,ARF5,ARG2,ATF3,ATP2A2,ATP2B1,BMP4,BMP6,CASP4,CBX4,CCL2,CCL8,CCND3,CCNL1,CDK4,CDO1,CEBPD,CNN1,COL3A1,CSF1R,CTGF,CXCL2,CXCL8,CYR61,DAB2,DBNDD1,DDIT3,DUSP1,DUSP5,EDN1,EGR1,EGR2,EGR3,EIF4E2,ETS1,ETS2,FHL1,FLNA,FMO1,FOS,FOSB,FRZB,FZD2,GADD45A,GDF15,GFPT2,GLUL,GPR183,GSS,H19,HBEGF,HMGCS1,HMOX1,HOMER2,HRAS,ID3,IER2,IER3,IGFBP4,IL6,JUN,JUNB,KLF6,LBP,LDLR,LMNA,MCL1,MMP2,MMP9,MYC,MYH1,MYH11,NOX4,NPR3,NR4A2,NR4A3,ODC1,PAWR,PCOLCE,PHLDA1,PLAT,PPP1R15A,PTGS2,RGS1,RHOB,RPN2,SERPINA3,SGK1,SLC2A3,SLC7A1,SOCS3,SPI1,TAGLN,TGM2,THBD,THBS1,TIMP1,TNFAIP3,TNFRSF12A,TOB1,TRIB1,TRIB3,TRIOBP,UNC5B,VCAM1,VCAN,ZFP36	Ap1,ERK,JUN,Jnk,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PDGF BB,RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1	
P1	 	tretinoin	 	chemical - endogenous mammalian	 	-0.020	 	0.172	-2.794	6.49E-22	ABCG1,ABI3BP,ACKR2,ADM,AGT,AHNAK,AKAP12,ALDH1A1,ALDH1A2,ALDH1A3,ALDH3A1,ALPL,ANGPTL4,ANXA5,AP1S2,APBB1IP,APCDD1,APLNR,APOE,AQP9,ASNS,ATF4,ATP2A2,ATP6V1B2,BAMBI,BCL2L1,BIRC3,BMP2,BMP4,BMP6,BNIP3L,BTG1,BTG2,C1QA,C5AR1,CAPN2,CBS/CBSL,CCL2,CCL3,CCL4L1/CCL4L2,CCND2,CCND3,CCPG1,CCR1,CCT5,CD14,CD1C,CD36,CD68,CD86,CDC20,CDH5,CDK4,CDKN2B,CDKN2C,CEBPG,CES1,CIDEA,COL1A1,COL1A2,COL3A1,COL4A5,CRABP1,CRABP2,CRAT,CSE1L,CSF1R,CSF3R,CSRNP1,CTGF,CTSB,CTSD,CTSK,CUBN,CXCL8,CXCR4,CYP11A1,CYP26B1,CYP2R1,CYP4B1,CYP4F11,CYR61,DAAM2,DAB2,DAP3,DAPK2,DDAH2,DDIT3,DHPS,DHRS3,DHRS9,DLEU1,DUSP1,EDN1,EEF1G,EFS,EGR1,EIF3B,EIF3C,EIF4EBP1,EIF4EBP2,EIF5,EIF6,ELN,EMP3,ENPP2,EPHX1,ERCC1,ETS1,ETV6,EYA2,FAM86C1,FASTK,FCER1G,FGF2,FLRT1,FOLR2,FOS,FOXC1,FST,FUBP3,G0S2,GAP43,GARS,GBP4,GCA,GDE1,GDF15,GFM1,GIMAP6,GM2A,HADHA,HBEGF,HDGF,HEY1,HEY2,HGS,HK1,HMGA1,HMOX1,HNRNPK,HOXA9,HSD17B11,HSPA2,ID1,ID3,IER3,IFI27,IFIT2,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL6,IMPDH2,ISLR,ITGA1,ITGAM,ITPR2,IVD,JCHAIN,JUN,KANSL3,KCNJ2,KDR,KIAA0513,KIT,KLF9,LAMP2,LBP,LEPR,LIPE,LRRC25,LRRK2,LSP1,LY6E,LYN,MAP1B,MAP2K3,MAP2K5,MAP7,MAPK8IP3,MAPKAPK2,MCL1,MDK,MECOM,MGP,MIA,MLF2,MMP28,MMP9,MNDA,MSC,MST1,MT1L,MT2A,MTHFD2,MYC,MYCN,NAA10,NCF2,NCL,NDRG1,NDUFA13,NDUFAF4,NDUFV1,NID2,NOTCH1,NRP1,NTRK3,ODC1,OGN,P2RX7,P4HA2,PADI4,PDCD4,PDE1B,PEG10,PFN1,PGA5 (includes others),PGD,PHLDA1,PKP2,PLA2G15,PLAT,PLAUR,PLCE1,PLEKHO2,PLIN2,PLOD3,PLS3,POMC,POR,PPP1R16B,PPP1R1B,PRKCD,PRMT1,PRNP,PSMB10,PTGDS,PTGIS,PTGS2,PTX3,PYCR2,RAE1,RALA,RAN,RARA,RARRES1,RARRES2,RARRES3,RET,RGS5,RNASE1,RNF10,ROR1,RPA1,RPL6,RUVBL1,S100A8,S100A9,SDCBP,SERPINE2,SFRP1,SLC12A2,SLC25A15,SLC7A2,SLCO2A1,SMAD7,SMOX,SMPD1,SNX8,SOX17,SOX7,SOX9,SP110,SPARC,SPI1,SPP1,SRGN,ST3GAL4,STC1,SYN1,TAF6,TF,TFRC,TGFBR2,TGFBR3,TGM2,THBD,THBS1,THRA,TIMP1,TJP1,TLE1,TMEM150A,TNFAIP3,TNFRSF10B,TNFRSF19,TNFSF10,TNIP1,TPP1,TPR,TSPAN14,TUBGCP2,TYROBP,TYSND1,UBA1,UCP2,VCAM1,VEGFC,VSIG4,WAS,WSB1,XAF1,XK,ZFP42,ZP3	CTNNB1,Creb,IFNG,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TGM2,TNF,tretinoin	
P1	 	D-glucose	 	chemical - endogenous mammalian	 	-0.477	 	0.105	-1.642	1.24E-21	AARS,ABCG1,ACACA,ACADM,ACLY,ACO2,ADAM17,ADIPOQ,ADRBK1,AGT,AKR1B1,ALDOA,ALDOC,ANO1,APOB,ASNS,ASS1,ATF3,ATF4,ATF5,ATP2A2,ATP2B1,BCL2L1,BMP2,BMP4,CANX,CARS,CAT,CAV1,CBR3,CCL2,CCND2,CCND3,CCPG1,CD36,CD55,CD59,CLGN,COL1A1,COL3A1,CTGF,CTSB,CXCL2,CXCL8,CXCR4,CYBA,DDIT3,DDIT4,DFNA5,DNAJB11,EDN1,EGR1,ELOVL6,ENO1,FBP1,FGF2,FKBP2,FOS,FST,G6PC3,G6PD,GAPDH,GCDH,GDF15,GFPT1,GLUL,GOT1,GPAM,GRN,H6PD,HIF1A,HK1,HMOX1,HNRNPK,HP,HSPA5,ID1,IDH1,IER2,IL6,IRS2,ITPR2,JUN,JUNB,KDR,LDLR,LEP,LIPE,LOC102724788/PRODH,LY96,MAPK7,MID1IP1,MIF,MMP2,MMP9,MTOR,MYC,NDUFB9,NEU1,NOX4,NQO1,NR4A2,NR4A3,ODC1,PC,PCCB,PCK2,PDCD4,PFKFB3,PFKL,PLAUR,PREB,PTGDS,PTGIS,PTGS2,PYCR1,RTN3,SARS,SEC61A1,SELE,SEPHS2,SGK1,SHC1,SLC1A3,SLC25A1,SLC25A10,SLC35B1,SLC39A8,SLC3A2,SLC7A1,SORBS1,SOX9,SPHK2,SPP1,SQSTM1,SRM,SRPRA,STUB1,STX1A,STXBP1,SUCLA2,TALDO1,TFRC,TGM2,THBS1,THRSP,TIMP1,TXNRD1,UCP2,VCAM1,WARS,YARS	AGT,Ap1,D-glucose,ERK1/2,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SMAD3,SP1,STAT3,TNF,dexamethasone	
P1	 	progesterone	 	chemical - endogenous mammalian	 	-0.004	 	0.152	-1.677	6.27E-21	ACAT1,ACOT7,ACP5,ACTA1,ADAMTS1,ADIPOQ,ADM,ADRA2A,ADRB2,AEBP1,AKR1C3,AKR1C4,ALDH1A1,ALDH1A2,ALPL,APOE,ASGR1,ATF3,ATP1A2,ATP6V1B2,BCL2L1,BIRC3,BMP2,BSG,C5AR1,CA12,CA3,CAV1,CCL2,CCND3,CD86,CDH2,CDKN2B,CEBPD,CES1,CFB,CIDEC,CLDN5,CNDP2,COL15A1,COMT,CSF3R,CST3,CTDSPL,CXCL12,CXCL8,CXCR4,CYP1B1,CYP2C8,DBP,DDIT3,DNAJB4,EDNRA,EGR1,ENPP2,EPAS1,ERBB2,ESR1,FAAH,FAM49A,FOS,FOXC1,FST,FTH1,G6PD,GABARAPL1,GAP43,GARS,GJB2,GPAM,GRINA,H19,HBEGF,HDC,HEY1,HIF1A,HLA-G,HSD11B2,HSPA2,HSPA8,ID1,ID3,IGFBP3,IL6,IRS2,ISG20,ITGA1,ITGA11,JUN,KCNAB1,KCNG1,KDR,KLF9,LAMA2,LEPR,LHCGR,LIG1,LIPE,LITAF,LPIN1,LXN,MAOA,MAP2K3,MBP,ME1,MME,MMP2,MMP9,MT2A,MTSS1,MYC,MYCN,MYO10,MYO1D,NDRG1,NEDD9,NET1,NFKBIA,NOP16,NPL,NRP1,NSUN5,P2RX4,PARM1,PBX3,PFKFB3,PKM,PMP22,PNKD,POMC,PRNP,PRPSAP1,PRSS23,PTGDS,PTGER4,PTGS2,PTX3,RAB11FIP5,RBP4,RELN,RNASE4,RTN4,S100P,SFRP4,SGK1,SLC1A5,SLC27A1,SLC2A3,SLC31A2,SMPDL3A,SPP1,SRD5A1,ST3GAL4,TBC1D8,TGFBR3,THBD,THRSP,TIMP1,TIPARP,TJP2,TNFRSF21,TNFSF10,TYMP,WNT5B	AKT1,ERK1/2,FOXO1,Growth hormone,HIF1A,IL1B,Insulin,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARA,PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,TP53,estrogen receptor,progesterone	
P1	 	HNF4A	0.141	transcription regulator	 	1.132	 	0.170	-0.103	1.30E-19	ABCC3,ABCG1,ABHD10,ACAT1,ACBD6,ACLY,ACO2,ACP2,ACP6,ACTN1,ACTR1A,ADGRB2,ADRB2,AGT,AHNAK,AHSA1,AJUBA,AK2,AKR1B1,AKR1C3,AKR1C4,ALDH1A1,ALDH2,ALDH3A1,ALDH5A1,ANG,ANXA5,APEH,APOB,APOC1,APOE,AQP9,ARFGAP1,ARG2,ARL17A/ARL17B,AS3MT,ASGR1,ATAT1,ATF4,ATG9A,ATP10A,ATP6V1D,ATP6V1F,AVPI1,AXIN2,BCL2L1,BLOC1S1,BRF2,BTG1,BUD31,C11orf54,C11orf68,C1orf123,C2,C21orf33/LOC102724023,C4orf19,CAMK2D,CAV1,CBR3,CBS/CBSL,CBX5,CCDC170,CCNG2,CCT8,CD55,CDC42BPB,CDC42EP2,CDCA5,CEBPD,CES2,CHCHD5,CHD1L,CHEK2,CIDEC,CLCNKA,CLPTM1,CMSS1,CNFN,COASY,COMMD9,COPS7A,COPS7B,COPS8,COQ8A,COX7A2L,COX8A,CPED1,CRABP2,CRAT,CRIP1,CS,CSK,CTDNEP1,CTSA,CTSB,CYP11A1,CYP1B1,CYP27A1,CYP2C8,CYP51A1,DBP,DCAF13,DDOST,DDX28,DDX41,DDX49,DHRS4,DHRS7B,DIABLO,DLG4,DNAJA3,DNAJB4,DNPH1,DPAGT1,DPH5,DPH6,DPM2,EGR1,EIF4EBP2,EIF5,ELMOD3,EMG1,EMX2,EPB41L4B,EPHX1,EVPL,EXOSC5,F11R,FAHD2A,FAM46A,FAM50B,FAM86C1,FBP1,FHL1,FIG4,FLNA,FLOT1,FOXRED1,FUK,G0S2,G3BP2,G6PD,GABRE,GALM,GAPDH,GBE1,GDF15,GFM1,GHITM,GJB2,GLYAT,GMDS,GNG5,GNL3,GOT1,GPC6,GPR137,GPR146,GPR160,GPX7,GRB14,GRWD1,GSK3B,GSPT1,GSS,GTPBP3,GUF1,GUSB,HADHA,HEXA,HEY1,HIF1A,HIF1AN,HIST2H2AA3/HIST2H2AA4,HLA-F,HLA-G,HPS6,HSPA5,HSPE1,IFT122,IGSF8,IL10RA,IL11RA,IMMT,INHBE,IPO13,ISOC2,JUN,JUNB,KIF3B,KLHDC3,KRT8,LAMTOR2,LARP4,LBP,LDLR,LIMS1,LMAN2L,LPGAT1,LRSAM1,LSM4,LZTR1,MAL2,MAOA,MAP2K5,MAP7,MAPK7,MAPK8IP2,MCEE,METAP2,MICU1,MID1IP1,MIPEP,MOCOS,MPZL2,MRPL15,MRPL2,MRPL22,MRPL24,MRPL27,MRPL37,MRPL4,MRPL43,MRPL51,MRPS12,MRPS15,MRPS18B,MRPS21,MRTO4,MSRB1,MSRB2,MST1,MT1X,MT2A,MTMR2,MYC,NAA10,NAT10,NBAS,NBEA,NCAPH2,NCBP2,NDRG1,NDUFA7,NDUFS3,NDUFV1,NEK7,NFE2L1,NME1,NMNAT2,NOC3L,NOL7,NOP16,NOSIP,NR1D1,NR5A2,NSF,NUDT2,ORM1,ORM2,OSBPL11,PALMD,PANK1,PCBD1,PCK2,PCMT1,PDCD4,PDIA5,PDK4,PEF1,PEG10,PEPD,PERP,PEX16,PEX6,PHPT1,PI4KB,PKM,PKP2,PLA2G4A,PLAA,PNMA1,PNPLA6,PNPO,POC1A,POLR1C,POLR3E,POLR3F,POLRMT,PPFIBP2,PPIL1,PPP1R11,PPP1R3C,PRDX5,PRKCE,PRMT1,PRPF31,PSAT1,PSMA3,PSMB5,PSMB7,PSMD7,PSME3,PTGDS,PTK7,PTPRE,RANGAP1,RAP1GAP,RARA,RASSF5,RBKS,RBM42,RBM6,RBP5,REXO2,RHPN2,RITA1,RNASE4,RNMTL1,RNPEPL1,RPAP3,RPLP1,RSU1,RTCA,S100A9,SAA1,SAA2,SARS2,SEMA3C,SERPINA3,SESN2,SF3B5,SGK1,SGSH,SLC19A3,SLC22A18,SLC25A1,SLC25A13,SLC25A19,SLC35B1,SLC38A1,SOX17,SOX9,SPATC1L,SPATS2L,SPP1,SRPRA,SRPRB,SSU72,STARD7,STIM1,STK19,STK24,STOM,STOML1,STOML2,STYXL1,SUCLA2,SUPV3L1,TACO1,TADA3,TAF6,TARS,TBC1D16,TEF,TENM4,TF,THOC3,THY1,THYN1,TIMM17B,TM7SF2,TMEM208,TMEM79,TRAPPC3,TRAPPC6A,TRMT112,TRMT12,TRPC4AP,TSPAN14,TUFT1,TXNDC12,TXNL1,TXNRD1,UBE2M,UBL7,UCHL1,UCP2,UROS,USMG5,USP36,USP5,UTP11,VAMP1,VEGFC,VEGFD,VIPAS39,VKORC1,WARS2,WBSCR22,WDR12,WDR13,WDR46,XPNPEP2,YIF1A,ZC2HC1C,ZFYVE19,ZNHIT1,ZNRD1,ZSCAN18	CEBPA,HDAC1,HNF4A,JUN,MYC,PPARG,STAT3	
P1	 	FSH	 	complex	 	-0.351	 	0.180	-1.637	3.98E-19	ACP2,ACP5,ACTA1,ACTG2,ACTN1,ADAM17,ADAMTS1,ADGRG1,ADM,AKAP12,ALDH3A2,ALPL,ARHGEF5,ATP2A2,ATP2B1,ATPIF1,AXL,BCKDK,BNIP3L,BTG2,CASP4,CCND2,CD55,CDH2,CDKN1C,CH25H,CLIP1,COL15A1,COL18A1,CRYM,CTGF,CXCR4,CYP11A1,DAB2,DHCR7,DHRS3,DUSP1,DUSP14,ESR1,FGF2,FLNC,FOS,FOSB,FST,GBP1,GDE1,GOT1,GRK5,ID1,ID4,IGFBP3,IGFBP4,IL6,ING1,INHBB,ISG20,ITGA3,JUN,JUNB,KIF5B,LDLR,LHCGR,LOX,LZTR1,MAP2K3,MAP4K4,MBD2,MCL1,MMP2,MMP9,MN1,MSMO1,MT1L,MT1X,MT2A,MYC,NEO1,NOL3,P4HA2,PAWR,PKM,PLAT,PPIH,PPP1CB,PPP2R1A,PRNP,PTGS2,PTPRE,PTPRF,RAB5A,RANGAP1,RAP1GAP,RARA,RGS12,RGS16,RGS5,RHOB,SGK1,SH3BP4,SMAD6,SMAD7,SRD5A1,STIP1,STK24,TF,TFPI2,TFRC,TGFBR2,TGFBR3,THBS1,TIMP1,TNFAIP3,TNFRSF10B,TOB1,TPM1,TRIB1,TYRO3,UPP1,VEGFC	Ap1,CEBPB,CREB1,Cg,ERK1/2,FOS,FSH,JUN,Lh,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT5B,cyclic AMP	
P1	 	ESR1	-0.550	ligand-dependent nuclear receptor	Inhibited	-2.338	 	0.070	-3.316	4.27E-19	ABCA3,ABCC3,ADAM17,ADCY1,ADORA1,AES,AGT,AHNAK,AK1,ALCAM,ANO2,ANXA3,AP2S1,APOE,AQP9,ARFGAP1,ARHGEF2,ARID4A,ARPC5L,ASS1,ATF3,ATF5,ATP2B1,AXIN2,BCL2L1,BIN1,BIRC3,BMP2,BMP4,BYSL,C1QTNF6,CAMK1,CAPN2,CARM1,CASQ2,CAV1,CCL2,CCND3,CCNG2,CCPG1,CD55,CD59,CD69,CDC42BPB,CDC42EP2,CDK4,CDK5RAP2,CDKN1C,CDKN2B,CEBPD,CEBPG,CHEK2,CHFR,CLCN3,CNN1,COBL,COG5,COL16A1,COL5A2,COL8A1,COMT,COPE,CPNE1,CRABP2,CSAD,CTNS,CTSB,CTSD,CXCL12,CXCL8,CYP11A1,CYP1B1,CYP26B1,DAB2,DDIT4,DHCR7,DNAJC1,DSG2,DTNA,DUSP10,DUSP5,EDN1,EFNB2,EGR1,ENAH,ENO1,ENPP2,ERBB2,ESR1,FAM102A,FHL1,FIBP,FKBP4,FLCN,FLNA,FOS,FOSB,FOXC1,FST,FZD2,G6PD,GADD45B,GCSH,GJB2,GLB1,GLRX,GM2A,GPAM,GUCY1A3,GULP1,H19,HACD1,HAX1,HBEGF,HDAC11,HIF1A,HIPK2,HLA-G,HOMER3,HSPA13,HSPA2,HYAL1,ICA1,ID1,IER3,IFI27,IFRD1,IGFBP3,IGFBP4,IL6,IMPDH2,INHBB,IRS2,ISG20,ITGA10,ITGB1BP1,JUN,JUNB,KCNMA1,KCTD13,KIF3B,KIF5B,KTN1,LBP,LDLR,LEP,LEPR,LHCGR,LILRB5,LIMA1,LMO3,MAP1B,MAP2K2,MAP2K5,MAP3K12,MAP3K20,MAP3K8,MAP7,MAPK8IP3,MAST2,MCOLN1,MIB2,MMD,MMP9,MST1,MYC,NCF2,NEDD9,NFKBIA,NIPSNAP1,NLGN1,NLGN4X,NME1,NOTCH1,NPR3,NQO1,NR1D1,OTUB2,PADI4,PCBD1,PDCD4,PDGFD,PDK4,PEF1,PGLS,PHF19,PLAUR,PLCE1,PLIN2,POR,PPP1R3C,PPP2R1A,PRKCD,PRSS23,PSAT1,PTGS2,PTPRT,PTTG1,PTX3,PVR,PYCR1,RABEP1,RAD21,RALA,RAMP3,RARA,RBP4,RDH5,RENBP,RERG,RGS16,RNF38,RPS6KA4,RPS6KB2,RRBP1,S100A9,S100P,SCAMP3,SCIN,SCUBE2,SELE,SEMA3B,SEMA3C,SGK1,SH3GLB2,SIAH2,SLC16A2,SLC1A4,SLC35B4,SLC39A8,SLC3A2,SLC7A1,SLC7A2,SLC7A5,SLC7A8,SMAD6,SMPD1,SOCS2,SORD,SOS1,SOX9,SP110,SPP1,SPTBN1,SPTLC2,SQSTM1,SRM,STC2,STX6,SUCLA2,SULF1,TBCD,TEK,TESK1,TFF3,TFRC,TGM2,THBS3,THBS4,TIMM17B,TJP1,TJP2,TM4SF1,TMEM2,TMEM97,TMOD1,TNFAIP3,TNFSF10,TNIP1,TOB1,TP53BP1,TPM1,TPR,TRIB1,TRIB3,TSC2,UBALD1,UQCR10,VAV3,VEGFC,VPS28,WARS,XK,YARS,ZNF544	4-hydroxytamoxifen,Ap1,CREB1,Creb,ESR1,ESR2,FOS,HDAC1,HIF1A,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,beta-estradiol,tamoxifen	
P1	 	F2	0.143	peptidase	 	-1.392	bias	0.453	-5.402	3.09E-18	AKR1B1,ALDH1B1,ANGPT1,ANGPTL4,BIRC3,CBR3,CCL2,CCL8,CCND2,CD55,CD68,CKAP4,COL1A1,CTGF,CTPS1,CXCL8,CXCR4,CYR61,DAAM1,DHRS9,DKK3,DOK5,DUSP1,EDN1,EGR1,ERP29,ETS1,FAM46A,FGF2,FHL1,FOS,FOSB,HBEGF,HIF1A,HMGA1,HMOX1,IER2,IER3,IGFBP4,IL6,JUN,JUNB,KDR,KLF6,LAMP2,MIF,MMP9,MTSS1,MYC,MYH11,NCF2,NCOA7,NFKBIA,NR4A3,PLA2G4A,PLAT,PLAUR,PRKCE,PROCR,PTGS2,RCAN1,RDH5,RHOB,RNH1,SAMD4A,SDC4,SELE,SLC16A5,SLC2A3,SLC2A6,SLC7A1,SLIT2,SPOCD1,SRGN,SRM,TEK,TFPI2,THBD,THBS1,TMED9,TNFAIP3,TNFRSF12A,TNFSF10,TOMM40,TXNRD2,VCAM1,YIF1A,ZNF205	Ap1,ETS1,F2,F2R,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1,VEGFA	
P1	 	ESR2	-0.240	ligand-dependent nuclear receptor	 	0.058	 	0.065	-0.452	9.71E-18	ADAMTS1,ADORA1,AES,AGT,AKAP12,ANO2,APOE,ARID4A,ARRDC4,ATF3,ATF5,ATP2B1,BCL2L1,BIN1,BMP2,BMP4,CA12,CADM3,CAPN2,CAV1,CBS/CBSL,CCL2,CDH2,CDKN1C,CEBPD,CES1,CNN1,COL11A1,COL16A1,COL1A1,COMP,CTGF,CTSD,CXCL12,CXCL8,CYP11A1,CYP26B1,DHCR7,DNAJC1,DUSP10,EDN1,EGR1,EGR3,ENPP2,ESR1,FHL1,FOS,FZD2,GCSH,GLB1,GLRX,GM2A,HSPA2,IGFBP3,IGFBP4,IMPDH2,IP6K3,JUNB,KAZALD1,KCNK15,KDR,KLF4,KRT8,LEP,LHCGR,LILRB5,LIMCH1,LMNA,LRP1B,LRRN3,MAOA,ME2,MMP2,MYC,NDRG1,NEDD9,NID2,NIPSNAP1,OTUB2,PCBD1,PDK4,PERP,PLAUR,PLEC,PLIN2,PPP1R3C,PSAT1,PTGDS,PTGFR,PTGIS,PTGS2,PTX3,PYCR1,RALA,RARA,RBP4,RELN,RPS6KA4,S100A9,SELE,SEMA3B,SERTAD4,SFRP4,SGK1,SOCS2,SOCS3,SORD,SPP1,SRXN1,STON1,SUCLA2,TENM4,TESK1,TGM2,THBS4,THRSP,TIMP1,TMEM2,TMIE,TPM1,TRIB1,TSPAN13,VAV3	4-hydroxytamoxifen,Ap1,CREB1,EGR1,ESR1,ESR2,HDAC1,HIF1A,IL6,JUN,MYC,NFKB1,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,beta-estradiol	
P1	 	APP	0.346	other	 	0.170	 	0.179	-1.539	1.03E-17	ABCG1,ABL1,ACO2,ACTA1,AES,AK1,ALDOA,ALDOC,AMPH,AP3B2,APOE,ARF5,ASCC1,ATF4,ATOX1,ATP1A2,ATP5D,ATP6V1E1,AXIN2,AXL,BCL2L1,BMF,BMP4,BMP6,BSG,C1QBP,C1R,CA12,CAMK2D,CANX,CAST,CAT,CCL2,CCL3,CCL3L3,CCND2,CCNG2,CD59,CD68,CD69,CD86,CDH2,CDH5,CDK4,CDK5RAP2,CH25H,CLDN5,CLTB,COL18A1,CRABP1,CRABP2,CRYL1,CRYM,CS,CSF1R,CTGF,CTSB,CTSD,CXCL12,CXCL2,CXCL8,CXCR4,CYP26B1,DLG4,DNM1L,EDN1,EEF1G,EGR1,ELMOD3,ELN,ENO1,ENPP2,EPAS1,ERBB2,ESR1,ETS2,FAM49A,FBL,FGF2,FKBP1A,FLNA,FOS,FOSB,FYN,FZD7,GALK1,GAP43,GAPDH,GBP4,GDF15,GNG2,GOT2,GPC1,GPM6B,GSK3B,GSTM3,H19,HARS,HAVCR2,HCAR2,HEY1,HEY2,HINT1,HIPK2,HK1,HMGA1,HMOX1,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPE1,IDO1,IFIT2,IGF2BP2,IGF2R,IKBKG,IL6,IRF3,IRS2,ISG20,ITGA1,ITGA3,ITGAM,JUN,JUNB,KAT2A,KCND2,KIF2A,LBP,LDLR,LHFPL2,LMO4,LRP1B,MAF,MAP1B,MAP2K2,MAP6,MAPKAPK2,MBP,MDK,MME,MMP2,MMP9,MTHFD1L,MYC,NAPB,NCDN,NENF,NME1,NR1D1,NR4A2,NRP1,OGN,PDCD4,PDXP,PEA15,PEBP1,PFKFB3,PIN1,PKM,PLAT,PPP2R1A,PRDX5,PRMT1,PRNP,PTGDS,PTGS2,PTPA,RAN,RCAN1,RELN,RNF144B,RNF24,S100A8,S1PR1,SDC4,SHC1,SIGMAR1,SLAMF8,SLIT2,SMAD7,SOCS3,SOX9,STIP1,STUB1,STXBP1,SYN1,SYN2,TAGLN,TGFBR2,THY1,TJP1,TNFRSF10B,TNFSF10,TPM1,TPP1,TUBA1C,TUBB,TUBB2A,TUBB2B,TUFM,TXN,UCHL1,VCAM1,VCAN,XAF1	APP,ATF6,Ap1,ERK1/2,IL1B,JUN,Jnk,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),PSEN1,RELA,SMAD3,STAT3,TP53	
P1	 	valproic acid	 	chemical drug	 	-0.446	 	0.010	-0.534	6.07E-17	ABCG1,ABHD5,ACACA,ADCY1,ADRM1,AKR1B1,AKR1C3,AKR1C4,AMFR,ATF3,ATF4,ATF6,ATP5I,BCL2L1,C1QTNF6,CA12,CARM1,CAT,CCL2,CCND2,CCR1,CD209,CDKN1C,CH25H,COCH,CRAT,CRYL1,CTAGE9 (includes others),CTPS1,CTSB,CXCR4,CYP11A1,CYP1B1,CYP2C8,CYP2R1,CYP51A1,CYR61,DDIT3,DHCR7,DNAJB11,DPM2,EDEM1,EDN1,ELOVL3,ELOVL6,ERN1,ESR1,ETV6,FAM107A,FOXC1,FSCN1,GADD45B,GAP43,GLUL,GPAM,GPX7,H6PD,HIF1A,HMGCS1,HMOX1,HSPA5,IGSF1,IL6,ING1,JUN,KIT,LAGE3,LDLR,LEP,LIMA1,LRP8,MCL1,MRPS2,MSMO1,MT1G,MVD,MYCN,MYOF,NME1,NOTCH1,PAQR7,PLAT,PLTP,PPRC1,PRAG1,PRKCD,PRSS23,PSMA3,PSMA4,PSMB10,PSMB2,PSMB5,PSMB6,PSMB7,PSMD14,PSMD7,PSME2,PSME3,PSME4,PTGS2,PTX3,RARA,RBBP8,RCL1,RERG,RNPEP,ROR1,SDPR,SEMA3C,SERPINH1,SGK1,SIAH2,SLC7A8,SMARCB1,SPI1,SPP1,SQLE,ST3GAL3,TENM3,TGM2,THBS1,THRSP,TNFSF10,TNS1,ZNF296,ZNF585A	AKT1,Akt,ERK1/2,ESR1,ESR2,HIF1A,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,TP53,beta-estradiol,valproic acid	
P1	 	FOS	-5.875	transcription regulator	Activated	2.642	 	0.140	1.573	1.41E-16	ABCC1,AGT,AKR1C3,ALDH1A3,AP3D1,ATF3,ATP2C1,BLMH,CAMK2D,CAPN2,CAST,CAT,CCL2,CD14,CD68,CELF2,CLIP1,CMTM4,COBLL1,COL16A1,COL18A1,COL1A1,COL6A1,CPSF1,CRABP1,CRABP2,CSTA,CTGF,CTSB,CTSH,CXCL16,CXCL8,DAPK2,DDX3X,DOCK1,EDN1,EGR1,EGR2,ELOVL3,ELOVL6,ENAH,ENO1,ERCC1,FARS2,FGF2,FLRT2,FOLR2,FOS,FOSB,FOXC1,FRZB,FTH1,FZD5,GBA,GKN1,GM2A,GSK3B,GSR,HMOX1,HSPA5,IL6,IRS2,JUN,JUNB,KIF2A,KIF5B,KLF6,KRT8,LAMP2,LARGE1,LOX,LRP8,LTBP2,MAOA,MAP3K20,MAP4K4,MMP2,MMP9,MPZL2,MT1A,MT2A,MYC,NCF2,NDUFS7,NET1,NGF,NIPSNAP1,NPTX2,NQO1,NR5A2,OCIAD2,ODC1,PCYT2,PFN1,PHLDA1,PKN1,PLA2G4A,PLAT,PLAUR,PMEPA1,POMC,PRKCE,PTGDS,PTGS2,PTS,PTTG1,RAP1GAP,RARA,RFNG,RNH1,RPL9,RPLP0,RPS24,RUNX1,S100A8,S100A9,SEMA3B,SERPINE2,SFRP2,SFRP4,SFTPD,SLC19A1,SMAD7,SOCS3,SPP1,STIM1,STX11,SULF2,SWAP70,TBCA,TCEA1,TIMP1,TIPARP,TNMD,TPP1,TRAPPC3,TUBB,TXN,VAV3,VCAM1,VEGFD,ZHX2	Ap1,EGR1,ESR1,ESR2,FOS,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,STAT3,TP53	
P1	 	hydrogen peroxide	 	chemical - endogenous mammalian	 	1.164	bias	0.313	-2.071	2.34E-16	ACAT2,ADAM17,ADIPOQ,ADRBK1,AEBP1,AEN,AGT,ATF3,ATF6,ATG7,BCL2L1,BIRC3,BSG,BTG2,CAT,CAV1,CCL2,CCL3L3,CCND3,CD55,CD59,CD68,CD86,CDC34,CDKN2C,CEBPG,COL1A1,COL1A2,CST3,CTGF,CTSB,CTSD,CXCL8,CXCR4,CYP51A1,DDAH2,DDIT3,DDIT4,DHCR7,DPAGT1,DUSP1,DUSP10,EDN1,EGR1,ELANE,ELN,ENPP2,EPAS1,ETS1,ETS2,FGF2,FOS,FTH1,FZD2,GADD45A,GADD45B,GDF15,GLRX,GSTM3,HBEGF,HDC,HIF1A,HMOX1,HRAS,HSPA5,ID3,IFIT2,IL6,ISCU,JUN,KDR,KIT,KLF2,KLF4,LDLR,MAPKAP1,MCAM,MCM2,MDK,MIF,MMP2,MMP9,MPV17,MSMO1,MYC,NAT10,NGF,NOL3,NUPR1,ODC1,OSGIN1,PCBP2,PDCD4,PKIA,PLAUR,PRKCSH,PTGER4,PTGS2,PTX3,RAN,RCN1,RTN3,SERPINH1,SGK1,SHC1,SLC20A1,SPARC,SPP1,SQLE,SRGN,TAGLN,TFRC,TGFBR3,TGM2,TNFAIP3,TNFRSF10B,TRIB3,TUBB2A,TXN,UCP2,UNG,UQCRH,VCAM1,XAF1	AGT,Ap1,D-glucose,ERK1/2,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SMAD3,STAT3,TNF,hydrogen peroxide	
P1	 	ATF4	0.848	transcription regulator	Activated	3.681	bias	0.419	0.969	2.40E-16	AARS,APBA3,ASNS,ATF3,ATF4,ATF5,CANX,CCL2,CEBPG,CHAC1,DDIT3,DDIT4,EDN1,EIF2S2,EIF4EBP1,FYN,GARS,GDF15,GHITM,GYS1,HSPA5,IARS,IL6,JUN,KLF4,KLF9,LARS,MARS,MCL1,MID1IP1,MT2A,MTHFD2,NARS,NDRG1,NID2,NUPR1,PCK2,PMP22,PPP1R15A,PSAT1,PTGS2,PTX3,PYCR1,SARS,SHMT2,SIGMAR1,SLC1A5,SLC3A2,SLC6A9,SLC7A1,SLC7A5,STC2,TNFRSF10B,TNFRSF12A,TRIB3,WARS,XPOT	ARNT,ATF4,BACH1,CEBPA,CEBPB,DDIT3,EPO,FOXO3,HIF1A,MYC,NFAT (complex),NFE2L2,NFKB1,NFkB (complex),PPARG,RELA,STAT1,STAT3,TP53,VHL	
P1	 	PD98059	 	chemical - kinase inhibitor	 	0.001	bias	-0.311	3.583	2.61E-16	ACAT2,ACOT7,ADIPOQ,AGT,AKAP12,ALDOA,ATF3,ATF4,BCL2L1,BMP2,CAV1,CCL2,CCL3,CCL3L3,CCND2,CCR1,CD14,CD36,CD4,CD55,CD69,CD86,CDH2,CDKN2B,CEBPD,CHN1,COL1A1,COL1A2,COL3A1,CTGF,CTSB,CTSH,CTSK,CXCL2,CXCL8,CXCR4,CYP1B1,DDIT3,DHRS3,DUSP1,DUSP5,EDN1,EGR1,EGR2,EGR3,EIF5,ELK1,ELN,EMP1,EMP3,ENO1,EPAS1,ERBB2,ETS1,FGF2,FOS,FOSB,FTH1,GADD45A,GAP43,GFPT1,GRN,GSK3B,HBEGF,HIF1A,HMOX1,HSD11B2,HSPA5,HYOU1,ID3,IER3,IGF2BP2,IGFBP3,IL6,ITGAM,JUN,JUNB,KRT8,LAMP2,LDLR,LEP,LIPG,LPGAT1,MAPKAPK2,MCL1,MIF,MMD,MMP2,MMP9,MT1F,MT1L,MT1M,MYC,MYCN,MYH1,MYH11,NAB1,NGF,NINJ1,NQO1,PAWR,PC,PFKFB1,PHLDA1,PHLDA2,PLA2G4A,PLAT,PLAUR,PLEC,POMC,PPP1R15A,PTGS2,RAN,RGS1,RNASE4,RPS2,RUNX1,S100A8,SELE,SIGMAR1,SLC35B1,SLC3A2,SOCS2,SOCS3,SPP1,SPRY2,SQLE,ST3GAL4,ST6GALNAC2,STOM,TF,THBS1,TIMP1,TNFRSF10B,TOMM40,TSC22D1,TUBB2A,TXN,TYMP,VAPA,VCAM1,VCAN,VEGFC,ZFP36L2	Ap1,EGF,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RAF1,RELA,STAT3,TNF,TP53	
P1	 	HRAS	0.899	enzyme	 	-0.567	 	0.170	-2.001	4.32E-16	ACTA1,ADM,ADRA2A,ALDH1A3,ANTXR1,ANXA3,ASNS,ATP2A2,BCL2L1,BMP4,BTG2,C1QC,CAPG,CAPN2,CAV1,CCDC80,CCND2,CCND3,CD24,CD69,CDK4,CDKN2B,CEBPD,CFB,CNN1,CNN2,COL18A1,COL1A1,COL1A2,COL3A1,COL5A2,COL6A2,CSTA,CTGF,CTSB,CXCL12,CXCL2,CXCL8,DDIT3,DOK2,DUSP1,EGR1,EIF3C,EIF4E2,EIF4EBP1,ELK1,ELN,EPHX1,ERCC1,ERP29,ETS1,FAT1,FGF2,FHL1,FLNA,FLRT2,FOS,FOSB,FZD2,GJB2,GPX3,GRN,GUSB,H2AFY2,HDC,HEY1,HEY2,HIF1A,HMOX1,HRAS,HSPA8,IGFBP4,IL6,ITGAM,JUN,JUNB,KLF6,LIPG,LPP,LSP1,LXN,LYZ,MAP3K8,MCAM,MMP2,MMP23B,MMP9,MRPL12,MSMO1,MSRB1,MTHFD1L,MYC,MYCN,MYH11,MYL3,NFKBIA,NID2,NOTCH1,NQO1,NRP1,NSFL1C,PAWR,PDIA5,PFN1,PIN1,PKP1,PLA2G4A,PLAUR,PLOD1,PLS3,PLTP,PMEPA1,POLR2G,PRKCD,PRNP,PRSS23,PTGS2,PTPRE,RAP1GAP,RGS12,RHOB,RPLP1,RSU1,RTN4,SERPINA3,SERPINE2,SORBS1,SPARC,SPON1,SPP1,SPRY2,SQLE,SYN1,TAGLN,TENM3,TGM2,THBS1,TINAGL1,TNFRSF10B,TOX2,TPO,TSC22D1,TSPAN6,TYMP,TYRO3,UBASH3B,VCAN,WSB2	ATF2,CEBPB,CTNNB1,EGFR,ERK,HDAC1,HRAS,JUN,MAP2K1,MYC,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TERT,TP53,TP73	
P1	 	IL1B	-0.392	cytokine	Inhibited	-2.052	 	0.225	-4.924	6.20E-16	ABCC3,ACKR2,ADAMTS1,ADM,ADRB2,AKR1B1,ALPL,ANGPT1,ANGPTL4,ANTXR1,APOB,APOE,ASS1,ATF3,ATF4,ATF5,ATP2A2,BAMBI,BCL2L1,BIRC3,BMF,BMP2,BMP4,BTG2,C19orf25,C1R,CASP4,CAT,CCL13,CCL2,CCL3,CCL3L1,CCR1,CD14,CD4,CD55,CD69,CD86,CEBPD,CEBPG,CFB,CLIP2,COL1A1,CSRNP1,CTGF,CTSB,CXCL12,CXCL2,CXCL8,CXCR4,CYBA,CYP11A1,CYTIP,DAB2,DBP,DDIT3,DDIT4,DUSP1,DUSP5,EDN1,EGR1,ELN,ENPP2,EPAS1,ERBB2,ESR1,ETS2,F13A1,FAM129A,FCER2,FGF2,FOS,FOSB,FST,G0S2,G6PD,GADD45A,GADD45B,GBP1,GDF15,GM2A,GRN,GSK3B,GUSB,GYS1,H19,HBEGF,HEXA,HIF1A,HMGA1,HMOX1,HP,HSPA1A/HSPA1B,ID3,IDO1,IER2,IER3,IFRD1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL18RAP,IL6,IRAK1,IRS2,ISG20,ITGA1,ITGAM,JUN,JUNB,KDR,LBP,LDLR,LEP,LOX,LY96,MAP3K8,MCL1,MFAP2,MIA,MIF,MMP2,MMP9,MT2A,MYC,MYH11,MYLK,NFKBIA,NFKBIZ,NGF,NQO1,NR1D1,NR4A2,NR4A3,NRP1,ODC1,ORM1,PCDH7,PHLDA1,PLA2G2A,PLA2G4A,PLA2G5,PLAA,PLAT,PLD3,POMC,PPP1R14A,PRKCD,PSMB10,PSME2,PTGDS,PTGFR,PTGIS,PTGS2,PTX3,RAN,RARA,RCAN1,RGS16,RHOB,RNASE1,S100A8,S100A9,SAA1,SAA2,SCUBE2,SDC4,SELE,SERPINA3,SERPINH1,SLC1A3,SLC20A1,SMAD7,SOCS2,SOCS3,SOX9,SPARC,SPP1,SRGN,TFPI2,TGFBR2,TGM2,THBD,THBS1,THRSP,THY1,TIMP1,TIMP4,TJP1,TNFAIP3,TNFSF10,TNMD,TOB1,TYMP,VCAM1,VCAN,VEGFC,ZFP36	IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,prostaglandin E2	
P1	 	IFNG	-0.137	cytokine	 	-0.653	 	0.226	-4.090	6.95E-16	ACLY,ADGRG1,ADGRG2,ADIPOQ,ADM,ADORA1,ADRA2A,ADRBK1,AGT,AHCY,ALDH1A3,ANGPTL4,AQP11,AQP9,ARG2,ASNS,ASS1,ATF3,ATF4,ATP2A2,BCL2L1,BMF,BMP6,BTG1,C1QA,C1QB,C1QC,C1R,C2,C5AR1,CASP4,CAT,CAV1,CCL13,CCL18,CCL2,CCL3,CCL3L3,CCL8,CCND2,CCR1,CD14,CD163,CD163L1,CD209,CD276,CD36,CD4,CD55,CD86,CDK4,CDKN2B,CEBPD,CERS6,CFB,CH25H,CHAC1,CHI3L2,CLEC10A,CLIP2,COL1A1,COL1A2,COL5A2,CSE1L,CSF1R,CSK,CTGF,CTSB,CTSD,CTSH,CTSK,CXCL12,CXCL16,CXCL2,CXCL8,CXCR4,CYB561,CYB5A,CYBA,CYP11A1,CYP27A1,DBP,DDIT3,DEFB1,DIABLO,DUSP1,DUSP5,EDN1,EDNRA,EFNB2,EGR1,EGR2,EGR3,ELK1,ELN,ERAP2,ERBB2,ETS2,F11R,FAAH,FAM107A,FAM26F,FBP1,FCER1G,FCER2,FCGR3A/FCGR3B,FECH,FGF2,FLAD1,FLRT2,FOS,FOSB,FTH1,FZD2,GBP1,GBP4,GDF15,GFM1,GJB2,GLIPR2,GLUL,GNG2,GPR146,GUSB,H6PD,HBEGF,HCAR2,HCAR3,HIF1A,HLA-DOA,HLA-DRB1,HLA-F,HLA-G,HMGA1,HMGCS1,HMOX1,HSPA1A/HSPA1B,HSPA8,ID1,IDO1,IER2,IER3,IFI27,IFIT2,IGFBP4,IL10RA,IL17D,IL18RAP,IL6,IRAK1,IRF3,IRS2,ISG20,ITGAM,ITPK1,JUN,JUNB,KCNMA1,KDR,KLF2,KLF4,KLF6,LAMP3,LARGE1,LEP,LOX,LY6E,LY96,LYN,MAP2K2,MAP3K8,METAP2,MIF,MMP2,MMP9,MNDA,MYC,MYCN,NCF2,NEDD9,NFE2L1,NFKBIA,NFKBIZ,NGF,NLRP3,NOTCH1,NQO1,NR1D1,NR5A2,NUPR1,ODC1,PCDH17,PEA15,PELI1,PHLDA1,PI4KB,PLA2G2A,PLA2G5,PLAUR,POMC,PPP1R1B,PRKCD,PRNP,PSMA4,PSMB10,PSME2,PSME3,PTGES2,PTGS2,PTPN23,PTPRB,RAB38,RARRES1,RARRES3,RBCK1,RFXANK,RGN,RHOB,RRAGD,S100A8,S100A9,S1PR3,SBF1,SDC4,SELE,SERPINH1,SFRP1,SHARPIN,SLC11A1,SLC12A2,SLC15A3,SLC1A3,SLC4A2,SLC52A2,SLC7A5,SMAD7,SMARCB1,SOCS2,SOCS3,SP110,SPI1,SPP1,SQLE,SQSTM1,STX11,SYNM,TFRC,TGFBR2,TGFBR3,THBS1,THOP1,THY1,TIMP1,TIMP4,TJP1,TMEM158,TMOD1,TNFRSF10B,TNFRSF12A,TNFRSF14,TNFSF10,TPO,TYMP,TYROBP,UNC5B,VCAM1,VEGFC,WARS,WBSCR22,ZFP36,ZPR1	IFNG,IL10,IL1B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF	
P1	 	CEBPA	0.073	transcription regulator	 	0.674	 	0.163	-0.948	1.10E-15	ABCA3,ACACA,ACLY,ADH1C,ADIPOQ,AGT,AKAP12,AKR1B1,AKR1B10,AKR1C3,APCDD1,APLNR,APOB,ARG2,ARHGEF5,ASNS,ASS1,ATF4,B9D1,BIN1,BTG1,BTG2,CCND2,CCR1,CD14,CDK4,CEBPD,CKAP4,CNFN,COL1A1,COL1A2,CRABP2,CSF1R,CSF2RA,CSF3R,CTSK,CXCL8,CXCR4,CYP11A1,DGAT2,DHCR7,EDF1,EFNB2,EGR2,ELANE,EMX2,EPHX1,EVPL,F8,FHL1,FOS,G0S2,GADD45A,GAPDH,GBP1,GLRX,GSK3B,GTF3A,HCAR3,HMGA1,HMOX1,HP,HSPA5,ID1,IER3,IFI27,IGFBP3,IGFBP4,IL6,IRS2,ITGAM,JUN,JUNB,LEP,LEPR,LHCGR,LITAF,MAPKAPK2,MNDA,MT2A,MYC,MYCN,NR4A2,NR5A2,NRP1,PGD,PIN1,PLIN1,PLIN2,PPP1R14A,PPP1R3C,PTGFR,PTGS2,PTPN3,PTPRE,PTX3,S100A8,S100A9,SAA1,SCAP,SERPINI1,SFTPD,SMPDL3A,SOCS3,SPI1,SPINT2,SPP1,THBD,THBS1,THRA,TIMP4,TNFRSF19,TNFSF10,TRIB1,TUBB2A,UBE2I,VCAN	Ap1,CEBPA,CEBPB,CTNNB1,ESR1,FOS,FOXO1,HDAC1,HDAC2,Histone h3,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RNA polymerase II,RXRA,SIN3A,SP1,STAT1,STAT3,TP53	
P1	 	thapsigargin	 	chemical toxicant	 	-1.021	bias	0.259	-2.969	1.39E-15	ADCY1,ADIPOQ,ADIPOR2,ASNS,ATF3,ATF4,ATF6,ATP2A2,BCL2L1,BIRC3,C5AR1,CAPN5,CAV1,CCL3L3,CCNG2,CD86,CHAC1,COL1A1,CSK,CXCL2,CXCL8,DDIT3,DDIT4,EDN1,EGR1,EGR2,ERBB2,ETS1,FOS,GADD45A,GADD45B,HDC,HIF1A,HMOX1,HSPA5,HSPA9,IER2,IL6,JUN,KLF4,LONP1,LPIN1,MCL1,MMP9,MYC,NFKBIA,NGF,NR4A3,PAWR,PCK2,PPP1R15A,PRNP,RCAN1,SERPINI1,SESN2,SGK1,STARD5,TGM2,THRSP,TMEM100,TNFRSF10B,TNFSF10,TPO,VCAM1	ERK1/2,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,thapsigargin	
P1	 	dihydrotestosterone	 	chemical - endogenous mammalian	 	0.921	 	0.242	-1.255	2.30E-15	ABCG1,ACACA,ACADVL,ACLY,ACO2,ACTA1,ADAMTS1,ADH1C,ADIPOQ,ADM,AES,AGT,ALDH1A3,ALDOA,ANO1,APOE,ATP13A2,ATP2A2,AXIN2,BCL2L1,BMF,BTG2,C1orf21,CA3,CANX,CCND2,CCND3,CCT3,CD36,CDC20,CDH2,CDO1,CMKLR1,COL3A1,COL5A2,COL5A3,COL6A1,CTGF,CYP11A1,CYP4B1,DHCR24,DLG4,EGR1,EIF4EBP1,ELN,ENO1,ERBB2,ESR1,FGF2,FOS,FST,FTH1,G0S2,GAP43,GAPDH,GLUL,GPX3,GRN,GRWD1,HINT1,HOMER2,HSD11B2,HSPA1A/HSPA1B,IGFBP3,IGFBP4,IL6,INHBB,IRS2,JUN,LDLR,LDLRAP1,LEP,LIPE,LOX,LY6E,LYZ,MAF,MCAM,ME1,MED16,MME,MMP2,MYC,MYLK,MYRIP,NDRG1,NEDD4L,NFKBIA,NID2,NOTCH1,ODC1,PA2G4,PC,PDCD4,PEA15,PFN1,PHLDA1,PMEPA1,POMC,PRNP,PTGER4,PTGS2,RAD21,RAD23A,RARRES2,RGN,RHOB,RPL8,RPL9,RPS24,SERPINE2,SFRP4,SGK1,SHC1,SLC1A3,SLC1A4,SLC1A5,SLC2A3,SLC2A5,SLC3A2,SLC4A7,SLC7A6,SLC7A8,SMG7,SPARC,SPP1,SQLE,SRD5A1,STXBP1,TACC2,TALDO1,TF,TGFBR2,TGFBR3,TGM2,THBS1,TRPM8,VCAM1,VCAN	AGT,AR,Akt,Ap1,CEBPB,ESR1,ESR2,HIF1A,JUN,NCOR1,NFKB2,NFkB (complex),NR3C1,PGR,PPARG,RELA,SMAD3,SP1,STAT3,TP53,beta-estradiol,dihydrotestosterone,progesterone	
P1	 	LY294002	 	chemical - kinase inhibitor	 	0.553	bias	-0.392	4.849	4.31E-15	ABCC1,ACACA,ACAT1,ADAMTS1,ADH1C,ADIPOR2,ADRB2,AGL,APOE,ATF3,ATF4,ATP2B1,AXIN1,BCL2L1,BIRC3,BMP2,BSG,BTK,CASP4,CCL2,CCL8,CCND2,CCND3,CCR1,CD14,CD36,CD69,CD86,CDK4,CDKN2B,CLCN3,COL1A1,COL1A2,CST3,CTGF,CUBN,CXCL16,CXCL2,CXCL8,CYP11A1,CYR61,DDIT3,DHCR24,DUSP1,EFNB2,EGR1,EGR2,EGR3,EMILIN1,EPAS1,ERCC1,ESR1,ETS1,ETS2,FGF2,FLRT2,FOS,FOSB,FOXC1,GBP1,GDF15,GPR183,GRN,GSK3B,GSR,GSTM3,HAVCR2,HBEGF,HIF1A,HLA-DRB1,HMGCS1,HMOX1,HSPA5,IER2,IER3,IGFBP3,IL6,INHBB,IRS2,ISG20,ITGAM,JUN,JUNB,LEP,LHCGR,LMNA,LOC102724428/SIK1,MAF,MAP3K8,MCL1,ME1,MMP2,MMP9,MT2A,MYC,MYH11,NDRG1,NFKBIA,NQO1,NR4A2,NR4A3,NTRK3,PHLDA1,PLA2G2A,PLAA,PTGS2,RAMP3,RGS1,S1PR1,SEMA3C,SGK1,SOCS2,SOCS3,SOS1,SPP1,SPRY1,SPRY2,SQLE,TFPI2,THBD,THBS1,TNFAIP3,TPO,TYMP,VAMP1,VCAM1,VCAN,VEGFC,ZFP36,ZFP36L2,ZNF75D	Ap1,CEBPB,HIF1A,IGF1,IL1B,JUN,LY294002,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT3,TNF,prostaglandin E2	
P1	 	EIF2AK3	-0.003	kinase	 	0.001	bias	0.406	-1.652	5.59E-15	AARS,ANG,ASNS,ATF3,ATF4,ATF5,ATF6,BIRC3,BTG2,CARS,CBX4,CEBPG,CLCN3,CYB5R1,DDIT3,EGR1,EIF4EBP1,EPRS,ETS2,FGF2,GADD45A,HSPA5,HSPA9,IARS,JUN,KLF4,LARS,LMO4,LONP1,MECR,MYC,NARS,NDRG1,NUPR1,PCK2,PPP1R15A,SARS,SHMT2,SIAH2,SLC1A4,SQSTM1,TARS,WARS,YARS,ZFP36	ATF4,Ap1,CREB1,Ca2+,E2F1,EGR1,EIF2AK3,FOXO1,FOXO3,HIF1A,JUN,Jnk,MXI1,NFKBIA,NFkB (complex),PPARG,RELA,SIRT1,SP1,STAT3,TP53,reactive oxygen species	
P1	 	Cg	 	complex	 	-0.168	bias	0.336	-3.276	5.74E-15	ADAMTS1,ADM,AKR1B10,AKR1C3,APCDD1,APLNR,BCL2L1,BMP2,BTG1,BTG2,BTG3,CCDC86,CCL2,CCND2,CDH2,CEBPD,CNPY4,COL11A1,CXCL8,CXCR4,CYP11A1,DHCR7,DPT,DUSP1,EFNB2,EGR1,EMP1,ENPP2,EPAS1,EPHB6,FHL1,FST,FYN,G0S2,GJB2,GM2A,GPC1,HIF1A,HMGA1,HSD11B2,IER3,IGFBP3,IGFBP4,IL6,INHBB,IRS2,ITGA1,JUN,KLF4,KLHDC4,LDLR,LEPR,LHCGR,LIMCH1,LRP1B,LRRN3,MAF,MAP2K5,MAPKAPK2,MCAM,MCL1,MMP2,MMP9,NPR3,NR2F6,NR5A2,NRP1,NUCB2,PFKFB3,PHLDA1,PKIA,PLAT,PLAUR,PPP1R14A,PTGFR,PTGS2,PTX3,RGS20,RUNX1,SDC4,SFRP4,SLC20A1,SLC52A2,SMAD6,SPP1,SPRY2,SRXN1,STC1,TENM4,TFPI2,TGFBR3,TIMP1,TIMP4,TM4SF1,TMEM158,TNFRSF12A,TRO,TSPAN13,UNG,UPP1,VCAN,VEGFC	CEBPB,CTNNB1,Cg,ERK1/2,ESR1,ESR2,HDAC1,JUN,NFKB2,NFKBIA,NFkB (complex),NOTCH1,PGR,RELA,SMAD3,SP1,STAT3,Vegf,beta-estradiol,progesterone,prostaglandin E2	
P1	 	leukotriene D4	 	chemical - endogenous mammalian	Inhibited	-4.849	bias	0.483	-7.528	9.05E-15	ADAMTS1,APOLD1,ATF3,BMP2,CCL2,CCL3,CCL3L3,CXCL2,CXCL8,CYR61,DUSP1,EGR1,EGR2,EGR3,HBEGF,IL6,KCNJ2,KLF2,KLF4,LOC102724428/SIK1,MAP3K8,MCL1,NDRG1,NEDD9,NR4A2,NR4A3,PDK4,PLAA,PTGS2,RCAN1,SELE,ZFP36	AR,Ap1,CREB1,Ca2+,EGR1,ERK,ERK1/2,JUN,NFKBIA,NFkB (complex),PI3K (complex),RELA,SIRT1,SMAD3,SP1,STAT3,TP53,leukotriene D4	
P1	 	cisplatin	 	chemical drug	 	0.317	 	0.149	-1.365	1.28E-14	ABCC3,ABL1,ACADM,ACADVL,ADAMTS1,ADRM1,AEBP2,ALDH1A3,ANXA5,ASCC1,ASNS,ASTN2,ATF3,ATF4,BCL2L1,BCL2L12,BHLHE41,BIRC3,BIRC7,BMP4,BNIP3L,BTG2,CAPN2,CAPN6,CAT,CAV1,CCL2,CCNG2,CCR1,CD14,CDKN2B,CDO1,CHEK2,CHFR,COL1A1,CORO7/CORO7-PAM16,CTGF,CTSB,CUL9,CXCL14,CXCL8,DDIT3,DDIT4,DHRS3,DOCK1,DUSP1,EDN1,EFEMP2,EGR1,EMP3,ERCC1,ESR1,FADS3,FOS,FYN,G6PD,GADD45A,GAMT,GAP43,GDF15,GMDS,GOT2,GPNMB,GSTM1,GSTM3,HADHA,HEYL,HIF1A,HIPK2,HK1,HMGCS1,HMOX1,HSPA5,HYAL1,IER3,IGFBP3,IL10RA,IL6,ITGA7,JUN,KATNB1,LBP,LMNA,LMO4,LPIN1,LXN,LYZ,MAOA,MARCH8,MCL1,MGP,MMP2,MYC,MYCN,NAT10,NCF2,NEO1,NOTCH1,NOX4,NQO1,NREP,ODC1,PAWR,PBX3,PDCD6,PDE3B,PDK4,PEBP1,PEX6,PFKL,PHLDA3,PIDD1,PIN1,PLAT,PROCR,PSMB10,PYCR2,RBP4,RCN1,RGL1,RGN,RNF144B,RPS21,RPS27L,RRM2B,RUNX1,SESN2,SLC22A5,SLC2A3,SLC39A3,SLC7A6,SMARCB1,SMOX,SMPD1,SOCS3,SPP1,SUSD2,THBS1,TIMP1,TNFAIP8,TNFRSF10B,TNFRSF12A,TNFSF10,TNK2,TOB1,TRO,TSC22D1,TUBB,TYMP,UCP2,UPP1,VCAM1,WDR4,ZMAT3,ZNF174,ZNF334	Ap1,ERK,ERK1/2,JUN,Jnk,MYC,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53,TP73,cisplatin	
P1	 	PGR	-0.024	ligand-dependent nuclear receptor	 	0.096	bias	0.326	-2.666	1.45E-14	ACP5,ADAMTS1,AHCYL1,AK4,AKR1C3,ALDH1A3,BCL2L1,BIRC3,BTG1,CA12,CAPN2,CCL8,CCND3,CD59,CDC20,CDH12,CDKN1C,CEBPD,CKAP4,COL6A1,COL6A2,COMT,CTDSPL,CTSD,DNAJB4,EDN1,EDNRA,EPAS1,ERBB2,ESR1,FAM49A,FOS,FOXC1,GLUL,GOT1,GPR160,GSTM3,H19,HBEGF,HIF1A,HSD11B2,HSPA2,ID1,IER3,IFI27,IRS2,KCNG1,KLF4,KLF9,LIG1,MAP2K3,MATK,MBOAT7,MFAP5,MTSS1,MYC,MYCN,MYO10,NDRG1,NEDD9,NET1,NFKBIA,NOP16,NQO2,NSUN5,P2RX4,P4HA2,PFKFB3,PTGS2,RASGRP2,RUNX1,S100A8,S100P,SLC31A2,SLC39A8,SLC7A5,SLC9A1,SPRY2,ST3GAL4,STC1,TBC1D8,TIPARP,TNFRSF21,VCAN	CEBPB,ERK1/2,ESR1,ESR2,IGF1R,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PGR,RELA,RNA polymerase II,SMAD3,SP1,STAT3,STAT5a/b,TP53,dexamethasone,progesterone	
P1	 	NFKBIA	-1.259	transcription regulator	 	-1.535	 	0.132	-2.852	1.46E-14	AEBP1,AK2,AXL,BCKDK,BCL2L1,BIRC3,BMP2,BRF2,BTG2,C21orf33/LOC102724023,CASP4,CCL2,CCL3L3,CCND2,CCR1,CD69,CD86,CEBPD,CH25H,CHI3L2,COL1A2,COL3A1,COL5A2,CSK,CTSB,CXCL12,CXCL2,CXCL8,CXCR4,CYBA,CYP1B1,DDIT3,DDX3X,ENPP2,ERAP2,ERBB2,FCGRT,FGF2,FOS,FSCN1,FZD7,GADD45A,GADD45B,GM2A,GPX3,GRK5,GRN,GSTM5,HEY1,HIF1A,HMGA1,HMOX1,HSPA5,HSPA8,IER3,IGF2R,IGFBP6,IL6,IPO9,IRAK1,IRX3,ITGA3,JUN,JUNB,KRT8,LIMA1,LITAF,LY6E,MATK,MGMT,MGP,MMP9,MSC,MYC,NAGLU,NFKBIA,NGF,NINJ1,OGN,PCDH7,PEA15,PLAT,PLD3,PMEPA1,POLR1C,PTGS2,PTX3,RABEP1,RCAN1,RGS16,RPL8,RPS2,S100A8,S100A9,SDC4,SELE,SEMA3C,SERINC1,SERPINE2,SFRP1,SGK1,SH3GLB2,SLC12A2,SLC16A2,SOCS3,SORL1,SOX9,SPTBN1,TCEAL9,TFRC,TIMP1,TNFAIP3,TNFAIP8,TNFRSF10B,TNFSF10,UBA1,VCAM1,VEGFC	Ap1,CHUK,HDAC3,IKBKB,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF	
P1	 	NFE2L2	0.307	transcription regulator	Activated	5.456	bias	0.330	2.113	2.85E-14	ABCC1,ABCC3,AKR1B10,ALAS2,ALDH3A1,ALDOA,ANG,AOX1,APBA3,ATF4,BCL2L1,CAT,CCT3,CD36,CD86,CDC34,CDKN2C,CLPP,COL1A1,COL3A1,CTGF,CTSD,CTSK,CXCL2,CXCL8,DDIT3,DHCR7,DNAJB11,EIF3C,ELN,EPAS1,EPHX1,ERP29,ETV6,FMO1,FTH1,G6PD,GBE1,GCLM,GNA11,GPX3,GSPT1,GSR,GSS,GSTM1,GSTM5,HACD3,HAX1,HMBS,HMOX1,HSPA9,IFRD1,IKBKG,IL6,KEAP1,KIFC2,LMNA,LY6E,MAFG,MATK,ME1,MMP9,MRPS18B,MSMO1,NARS,NCF2,NFE2L1,NQO1,NSMF,NUCB2,OSGIN1,P2RX4,PGD,PIP5K1C,PKIA,PSAT1,PSMA4,PSMB2,PSMB5,PSMB6,PSMD14,PSMD7,PTGS2,PTPRB,RAMP2,RAN,RELN,RPLP0,RUVBL1,S100P,SAA1,SEC61A1,SERPINA3,SHC1,SLC16A2,SLC1A4,SLC35B1,SLC6A9,SLC7A8,SOCS3,SQSTM1,SRXN1,STIP1,SYN2,THRSP,TMED2,TUB,TXN,TXNRD1,VCAM1	Ap1,BACH1,CREB1,EP300,FOS,HMOX1,IL13,IL1B,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,STAT3,STAT6	
P1	 	NKX2-3	0.021	transcription regulator	Activated	2.206	 	0.005	2.166	3.11E-14	ADAMTSL2,ADM,AGAP3,ALPL,ANGPTL4,ASNS,BCYRN1,BMP2,BMP4,BTG1,C2CD4B,CBS/CBSL,CD36,CD68,CENPW,CSRNP1,CXCL16,CXCL8,DANCR,DCLK1,EDN1,EIF4EBP3,FAM46A,FAR2,FBN2,FCN3,FGF2,FLRT2,GALNT15,GBP1,GCA,GDF15,HEY1,HEY2,HIST2H2AA3/HIST2H2AA4,HIST2H2AC,HLA-F,IDO1,KLF2,KLF4,LGMN,LY6E,MAMDC2,MCTP1,MT1M,MTURN,MYO5A,PARP10,PAWR,PKIA,PSAT1,PTGS2,PTPRE,SDPR,SERPINE2,SHMT2,SMAD7,SP110,SRPX,SYT11,TCTEX1D2,TFF3,TFPI2,TIPARP,TMEM100,TMEM158,TRIM5,TXNDC12,TYMP,VCAM1,XAF1,ZMAT3	 	
P1	 	UCP1	-0.060	transporter	Activated	4.174	 	0.150	3.086	3.23E-14	AARS,ACACA,ARHGEF2,ASNS,ATF4,ATF5,ATG7,BCAT2,BZW2,CCDC136,CEBPG,CHCHD10,CLCN3,CYB5R1,DDIT3,DKK3,EIF4EBP1,ERN1,G6PD,GADD45A,GARS,GDF15,GHITM,GOT1,GPX3,GSR,GSTM1,KCNAB1,LEP,MTHFD1L,MTHFD2,MYC,MYH1,NT5C,NUPR1,ODC1,OTUB2,PCK2,PGD,PGLS,PSAT1,PYCR1,REEP6,SHMT2,SLC3A2,SLC6A9,SMOX,SRM,SYNM,TBC1D31,TENM4,TRIB3,UCP2,XPOT	CEBPB,JUN,NFkB (complex),STAT1,STAT3,UCP1,cyclic AMP	
P1	 	camptothecin	 	chemical drug	 	0.356	 	0.147	-0.915	4.31E-14	AEN,AK4,ALDOA,APOE,ARFGAP1,ARHGDIA,ATF3,BAMBI,BCL2L1,BIRC3,BNIP3L,BTG2,BTG3,BTK,C11orf68,C1orf216,CARD8,CASP4,CAST,CCL2,CCL3,CCR1,CD59,CD86,CDC42EP2,CDK4,CHAC1,CIDEA,CLTB,CXCL2,CXCL8,DNM1L,DPAGT1,DUSP10,EDN1,EGR2,FOS,FOSB,FOXC1,FSCN1,FZD7,GADD45A,GADD45B,GAMT,GAPDH,GAPVD1,GDE1,GPNMB,GRINA,GRK5,GSR,GTPBP6,H3F3A/H3F3B,HBEGF,HCAR3,HIF1A,HLA-F,HLA-G,ID1,ID3,IGFBP3,IL10RA,IL6,IMPA2,ITGA7,ITSN1,JUN,KIF3B,LDLR,LIMCH1,LITAF,LOC102724788/PRODH,LPIN1,MAP2K5,MAP4K4,MBOAT7,MCL1,MFSD5,MGMT,MIR22HG,MKL2,MMP9,MYC,MYO10,MYO5A,NCL,NFKBIA,NR4A2,NRP1,ORM1,P2RX4,PCGF1,PDLIM7,PDZD2,PERP,PHLDA2,PIDD1,PIK3C2B,PLEC,PLIN2,PPFIBP2,PTGER4,PTGS2,PTPRK,PTX3,RAPGEF5,RARA,RASGRP2,RCN1,RND2,RRAGD,RRM2B,RSU1,SAA1,SDC4,SELE,SIAH2,SORL1,SOWAHC,SPP1,SPRY2,SPTBN1,STC2,STX11,TBC1D31,TFRC,THAP10,THBD,TLN2,TMEM158,TNFAIP3,TNFRSF10B,TNK2,TOB1,TP53BP1,TPM1,TPP1,TRIB1,TRO,TUBB,TUBB2A,TWNK,VAC14,VAV3,VCAM1,ZHX2,ZNF408,ZP3	ERK,GSK3B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53,camptothecin	
P1	 	forskolin	 	chemical toxicant	 	-0.992	 	0.242	-3.585	4.60E-14	ACP5,ACTA1,ACTG2,ACTN1,ADAMTS1,ADGRG1,ADIPOQ,ADSL,AKAP12,ALDH3A1,ALDOA,ALDOC,ALPL,ARHGEF5,ATF3,ATP6V0B,ATP6V1B2,AVPI1,BNIP3L,BTG2,CASP4,CCND2,CCND3,CD14,CD4,CD55,CD68,CD86,CDH2,CDKN1C,CDKN2B,CEBPD,CIDEC,CNN1,COL15A1,COL18A1,COL1A1,CRHBP,CRISPLD2,CTGF,CXCR4,CYP11A1,CYP1B1,DAB2,DDIT3,DDIT4,DHCR7,DHRS3,DNM1L,DUSP1,DUSP14,EDN1,EGR1,EMD,ESR1,FCER1A,FLNC,FOS,FOSB,FST,GADD45A,GADD45B,GAP43,GBP1,GPRC5C,GRK5,GRN,GSTM5,H19,H3F3A/H3F3B,HIF1A,HMOX1,HP,HSD11B2,HSPA1A/HSPA1B,ID1,ID3,IER2,IER3,IGFBP3,IGFBP6,IL6,ING1,INHBB,IRS2,ITGA3,ITPR2,JUN,JUNB,KLF4,LARGE1,LEP,LHCGR,LITAF,MAP2K3,MAP4K4,MIF,MMP23B,MMP9,MSMO1,MYC,NFKBIA,NGF,NNAT,NOL3,NPTX2,NR4A2,NR4A3,OCIAD2,ODC1,ORM1,P4HA2,PAWR,PDK4,PEG10,PLAT,POMC,PPIH,PPP1R3C,PPP2R1A,PTGS2,PTPRE,PTPRF,RAB5A,RANGAP1,RGS5,RHOB,RUNX1,S100A8,S1PR3,SERINC2,SGK1,SH3BP4,SHC1,SLC2A5,SLC7A8,SMAD7,SPP1,SRXN1,STARD7,STC1,STK24,TFPI2,THBS1,THRSP,TIMP1,TJP1,TM4SF1,TMBIM1,TNFAIP3,TPM1,TPO,TRIB1,UCP2,UPP1,VCAN,VNN2,ZHX2	CEBPB,CREB1,CREBBP,CREM,Creb,FOS,FSH,IL1B,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,STAT5B,TNF,forskolin	
P1	 	NR3C1	-0.274	ligand-dependent nuclear receptor	 	-0.443	 	0.085	-1.027	5.65E-14	ABL1,ACAT1,ACTN1,ADCK4,ADH1C,ADM,AGT,ANGPTL4,APOE,APTX,AS3MT,ATP6AP1,BCL2L1,BIN1,BIRC3,BMF,BMP2,BNIP3L,BRE,BTG1,BTK,C1QTNF1,C1R,CAPN2,CASP4,CAT,CAV1,CBX4,CCL2,CCL3L3,CD69,CDKN1C,CIDEA,CIDEC,CLDN5,COMT,COQ8A,CSRNP1,CSRNP2,CXCL2,CXCL8,CYP11A1,CYP27A1,CYP2C8,CYR61,DAPK2,DDIT4,DEAF1,DGAT2,DIABLO,DMAP1,DNAJC15,DNASE1L3,DPP7,DUSP1,DUSP22,EDN1,EGR1,ELMOD3,EMP1,EPB41L4B,ERN1,FCER1G,FKBP4,FNTA,FOS,GADD45A,GADD45B,GAP43,GLUL,GPX3,GULP1,H6PD,HCAR2,HSD11B2,IDH1,IER2,IER3,IFIT2,IFT122,IL6,ING1,IP6K3,JUN,KLF9,LEP,LMO4,MAOA,MAP3K20,MAPK7,MBD2,MCL1,MGMT,MKNK2,MMP9,MSRB1,MT1L,MTCH2,MYC,MYOC,NFKBIA,NLRP3,NMT1,NOL3,NSMAF,PAWR,PDCD4,PEA15,PHLDA2,PLEKHF1,PLIN2,POMC,PPP1R15A,PRKCD,PRKCE,PRPH,PTGS2,RAD21,RASD1,RHOB,RNF10,RNF38,RRAGC,RTN4,S100P,SCAP,SDPR,SELE,SEMA3C,SERP2,SGK1,SGPL1,SH3GLB1,SIAH2,SLC2A5,SLC38A1,SLC7A6,SPP1,SPPL2B,ST3GAL3,STK39,STOM,STON1,STUB1,TADA3,THBD,THBS1,TIPARP,TNFAIP3,TNFAIP8,TNFRSF10B,TNFRSF12A,TNFRSF21,TPST2,TRIB3,TXN,UNC13B,VCAM1,WDR12	Ap1,HIF1A,JUN,Jnk,LEP,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARG,RELA,RNA polymerase II,SP1,STAT3,dexamethasone	
P1	 	VEGFA	-0.390	growth factor	 	-0.593	bias	0.382	-3.849	6.64E-14	ABCC1,ACADM,ADAMTS1,AK4,ALDH2,ANGPT1,ARG2,BCAT2,BMP4,BTK,CAV1,CCL2,CD55,CDH5,COL1A1,COX8A,CST3,CSTB,CTGF,CTSB,CXCL12,CXCL8,CXCR4,CYR61,DUSP5,EDN1,EFNB2,EGR1,ETS1,ETS2,ETV5,FGF2,FOS,GBP1,HAVCR2,HBEGF,HIF1A,HK1,HMOX1,ID1,ID3,IGFBP4,IL6,ITGA1,JUNB,KDR,LMNA,LOC102724828/MRPL23,MCL1,ME2,MEOX2,MMP2,MMP9,MRPS12,MYCN,MYLK,NME1,NOTCH1,NRP1,PLAT,PTGS2,RAB5A,RCAN1,RUNX1,SELE,SHMT2,SLC25A6,SPARC,STC1,SYNM,TBC1D8,TEK,TFPI2,THBD,THBS1,TJP2,TUFM,UNC5B,VCAM1	CEBPA,CEBPB,CREB1,ERK1/2,FGF2,FOS,JUN,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,SP1,STAT1,STAT3,TP53,VEGFA	
P1	 	AGT	1.383	growth factor	 	0.364	bias	0.254	-2.240	8.58E-14	ACAT2,ACTA1,ADAM17,ADH1C,ADIPOQ,ADM,AGT,ANGPT1,ANXA3,ATF3,ATP2B1,BMP6,CAT,CAV1,CCL2,CCL3L3,CCL8,CCND2,CCND3,CD36,CD86,CDK4,CLGN,COL1A1,COL1A2,COL3A1,COL6A1,CRABP2,CREB5,CTGF,CXCL2,CXCL8,CYBA,CYTH3,DAB2,DDAH2,DUSP1,EDN1,EDNRA,EFNB2,EGR1,ETS1,FGF2,FOS,GALNT13,GAP43,GFPT1,GRK5,GSK3B,GSS,GSTM5,HBEGF,HEY1,HIF1A,HMGCS1,HMOX1,HOXA9,HSPA1A/HSPA1B,ID3,IDH1,IGFBP3,IGFBP4,IL6,INHBB,ITGA7,ITPR2,JUN,LDLR,LEP,LEPR,LPP,LSS,MAPK7,MATN2,MIF,MMP2,MMP9,MSMO1,MYC,NCF2,NCL,NDRG1,NGF,NMNAT2,NOX4,NPR3,NR4A2,NREP,PFN1,PIR,PNKD,PPP1R3C,PTGFR,PTGS2,RCAN1,SELE,SEMA6A,SGCD,SGK1,SHC1,SLC9A1,SMAD7,SOCS3,SPP1,SRGAP3,STC1,TFRC,TGFBR2,THBD,TIMP1,TJP1,TLN2,TNFRSF12A,UCP2,VCAM1,VEGFC,ZFP36	AGT,Ap1,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1,TNF,Tgf beta	
P1	 	CREB1	-0.106	transcription regulator	Inhibited	-2.873	 	0.152	-4.361	1.29E-13	ADM,ADRA1A,AK4,APOE,APOLD1,AQP11,ATF3,ATF5,ATP5I,ATP6V0B,BCAP29,BCL2L1,BHLHE22,BRINP2,BTG2,CADPS2,CAPN5,CARS,CCDC85A,CCL3,CCND3,CD4,CD68,CDH2,CEBPD,CH25H,CIART,CNN1,COCH,COX8A,CPEB1,CRHBP,CRYM,CSRNP1,CXCL2,CXCL8,CXCR4,CYP11A1,CYP51A1,CYR61,DUSP1,DUSP14,EDN1,EGR1,EGR2,ETV6,FAM46A,FAM65B,FOS,FOSB,GAA,GABARAP,GADD45A,GADD45B,GAP43,GPNMB,HLA-G,HMGCS1,HMOX1,HSPA4,HSPA5,ID1,IER2,IER3,IGSF10,IL6,IRS2,JUN,JUNB,KCND2,KDELR3,KIAA1549L,LDLR,LEP,LITAF,LSS,MCAM,MCL1,MCTP1,MKNK2,MNS1,MRPS18B,MSMO1,MTSS1,MVD,MYC,NDUFA10,NDUFV1,NEO1,NNAT,NPTX2,NR4A2,NR4A3,NREP,NRP1,OCIAD2,PDE3B,PEG10,PLAT,PPP1R15A,PTGS2,RBP4,RERG,RNH1,RRAS2,S1PR3,SERINC2,SERPINI1,SERTAD1,SFRP4,SGK1,SIAH2,SLC19A1,SLC2A3,SLC35G2,SMAD6,SOCS2,SQSTM1,SRD5A1,SRXN1,STC1,SYN2,TCEAL9,TF,TFRC,THOP1,TIPARP,TMBIM1,TPO,TXN,UPP1,WARS2,ZFP36,ZFPM2	CEBPA,CEBPB,CREB1,CREBBP,CREM,CTNNB1,Creb,EP300,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT1,STAT3,TP53	
P1	 	FGF2	0.804	growth factor	 	1.937	bias	0.255	-0.359	1.65E-13	AGAP3,AKR1B1,AKR1B10,ANG,ANGPT1,ANGPTL4,ATF4,BCL2L1,BMP4,BTG2,CAV1,CCL2,CCND2,CCND3,CIDEC,COL1A1,COL1A2,COL3A1,CTSK,CXCL12,CXCR4,CYP11A1,CYR61,DDIT3,EFNB2,EGR1,ELK1,ELN,ENO1,ENPP2,EPAS1,ETS1,ETV5,FGF2,FLNA,FOS,FTH1,GADD45A,GAP43,GBP1,GPNMB,HBEGF,HIF1A,ID3,IGFBP3,IGFBP4,IL6,ITGA3,JUN,JUNB,KDR,LMNA,LOX,LYVE1,MBP,MCAM,MEOX2,MGMT,MGP,MIF,MMP2,MMP9,MYC,NOTCH1,NR4A2,ODC1,PLAT,PLAUR,PRKCD,PRKCE,PTGS2,PTPRE,PTTG1,RUNX1,S100A8,SELE,SFRP1,SLC20A1,SOCS3,SOX9,SPARC,SPP1,SPRY1,SPRY2,SQSTM1,ST3GAL3,ST3GAL4,TAGLN,TF,TGFBR3,THBS1,TIMP1,TNFRSF12A,TNFSF10,TPO,USP47,VCAM1,VEGFC	ATF2,CEBPB,EGFR,ERK1/2,FGF2,HIF1A,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNF	
P1	 	EGF	0.090	growth factor	 	0.990	bias	0.307	-2.099	1.71E-13	ACSL4,ACTN1,ADAM17,ALCAM,ANGPT1,ARHGEF2,ATF3,ATP2A2,BCL2L1,BTG2,CAV1,CCND2,CCND3,CDC34,CEBPD,CLCN3,COL1A1,COL1A2,COL3A1,CSF1R,CSN1S1,CTGF,CTSD,CXCL14,CXCL8,CXCR4,CYP11A1,CYR61,DDIT3,DUSP1,DUSP5,DVL2,EDN1,EGR1,EGR2,EGR3,ELK1,ENAH,EPAS1,ERBB2,ERCC1,ESR1,ETS1,ETS2,FGF2,FOS,FOSB,FST,GADD45A,GFPT1,GLG1,GPS2,GSK3B,HBEGF,HIF1A,HMGCS1,HMOX1,HNRNPK,HRAS,ID1,IDH1,IER2,IER3,IGFBP3,IGFBP4,IL6,ITGAM,JUN,JUNB,LHCGR,MCL1,MMP2,MMP9,MST1,MYC,MYCN,NCL,NGF,NOTCH1,NR4A2,NR4A3,NRP1,ODC1,PDCD4,PDK4,PFKFB1,PHLDA2,PLAT,PLAUR,PSMB2,PSMB5,PSMB6,PSMB7,PTGS2,PTTG1,RAB5A,RALA,RHOB,RUNX1,S100A9,SDPR,SERPINA3,SHC1,SLC4A7,SOCS3,SPARC,SPI1,SPP1,SPRY2,ST3GAL3,ST3GAL4,TFPI2,TGFBR2,TGM2,THBS1,TIMP1,TJP1,TNFRSF12A,TNFRSF4,TUFM,VCAM1,VCAN,VEGFC,ZFP36,ZFP36L2	ATF2,Akt,EGF,EGFR,ERK,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53,prostaglandin E2	
P1	 	PPARG	0.401	ligand-dependent nuclear receptor	 	0.201	 	0.162	-1.271	1.93E-13	ABCA3,ABCG1,ACACA,ACADM,ACLY,ACSL4,ADIPOQ,ADIPOR2,ADRB2,AGT,ALDH1A2,ANGPTL4,APOE,ATP2A2,ATP6V1D,BIN1,CAT,CAV1,CCL2,CCPG1,CD36,CDKN2C,CES1,CIDEA,CIDEC,COL1A1,COL1A2,CRABP2,CRAT,CS,CTGF,CTPS1,CXCL14,CXCL2,CXCL8,CYBA,CYP4B1,DGAT2,DHRS3,EDN1,EIF4EBP1,ELOVL6,EPHX1,ETS1,F11R,FST,GAPDH,GDF15,GPAM,H6PD,HADHA,HMOX1,HP,HYOU1,IDH1,IGFBP3,IGFBP6,IL6,IRS2,IVD,JUN,KLF4,KLF6,LDLR,LEP,LHPP,LIPE,LOC102724788/PRODH,MCTP1,ME1,MKNK2,MMP9,MRTO4,NDRG1,NOX4,NR1D1,NSF,ODC1,PACS1,PC,PCK2,PCLO,PDE3B,PDK4,PEA15,PEPD,PEX6,PFKFB3,PLA2G2A,PLIN1,PLIN2,PTGS2,PTPRF,RARRES2,RBP4,RGL1,RHOB,RNF144B,S100A8,SAA1,SDPR,SELE,SGK1,SLC27A1,SLC9A1,SMO,SNX1,SOCS3,SORBS1,SPP1,STIM1,TGFBR2,TJP1,TNFSF10,TRIB3,TUBB,UCP2,VCAM1	Ap1,EGR1,HIF1A,JUN,LEP,NFkB (complex),NR3C1,Nr1h,PPARA,PPARG,RELA,RNA polymerase II,RXRA,SP1,SREBF1,STAT3,pioglitazone,rosiglitazone,troglitazone	
P1	 	Vegf	 	group	 	-1.690	bias	0.368	-5.741	2.24E-13	ADAMTS1,ADGRF5,ADGRG1,AKAP12,ANGPTL4,APLNR,ASNS,ATF3,AXIN2,BIRC7,BMP2,C1QTNF1,CALCRL,CDC20,CDH5,CDKN2C,CNN1,CPA3,CRABP1,CSE1L,CXCL12,CXCL8,CXCR4,CYR61,CYYR1,DDIT3,DDX11,DDX3X,DHPS,DKC1,DOK5,DUSP5,EDN1,EFNB2,EGR1,ELN,EMP1,ENPP2,ETS1,ETV5,FANCG,FGF2,FLNA,FOSB,FST,GJB2,GPR4,GRB14,GRK5,HBEGF,HDC,HIF1A,HMOX1,ID1,IGFBP3,IGFBP4,IL17RC,IL6,INHBB,ISG20,ITGA10,KDR,LDLR,LPAR1,LRP8,LYN,LYVE1,MAP2K3,MAP3K8,MAPKAPK2,MCL1,MCM2,MEOX2,MGP,MIF,MMP2,MMP9,MT1G,MYC,MYCN,NID2,NOP2,NOTCH1,NPL,NR4A2,NR4A3,NR5A2,NRP1,OSBPL10,PC,PHLDA1,PHLDA2,PLAUR,PMP22,PPAN,PPP1R1B,PTGS2,PVR,RAMP3,RCAN1,RGCC,RGS20,RNF125,SELE,SFRP1,SGK1,SLC20A1,SLC7A1,SLC7A2,SLCO2B1,SLK,SNRK,SOCS2,SOCS3,STC1,TBC1D8,TGFBR2,THBD,TIMP1,TJP1,TMEM158,TNFRSF10B,TRIB1,VAV3,VCAM1,VEGFC	Ap1,ERK1/2,ETS1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1,VEGFA,Vegf	
P1	 	EGFR	0.186	kinase	 	-0.399	 	0.202	-2.130	2.68E-13	ACOT7,ACTA1,BCL2L1,BTG1,CASP4,CAV1,CCL2,CCNG2,CDK4,CELF1,COL1A1,COL3A1,COL5A2,COL6A1,COL6A2,COL8A1,CST3,CTGF,CTSK,CXCL12,CXCL8,CXCR4,DDIT3,DSG2,DUSP1,EFNB2,EGR1,EGR3,EIF6,ELK1,ERBB2,FOS,GADD45A,GBP1,GPC1,GRN,HBEGF,HDC,HIF1A,HNRNPH1,HNRNPK,HP,HSD11B2,HSPA5,ID1,IER2,IER3,IGFBP3,IGFBP4,IL6,JUN,JUNB,KIAA0391,MATN2,MCL1,MME,MMP2,MMP9,MT1F,MT1L,MT1M,MYC,NOTCH1,PARP2,PLAT,PLAUR,PSMB2,PSMB5,PSMB6,PSMB7,PTGER4,PTGIS,PTGS2,PTPRE,RHOB,RUNX1,SDF2L1,SERPINA3,SERPINE2,SFRP1,SLC2A3,SLC4A7,SOCS3,SOX9,SPRY2,TGM2,THBS1,TUBG1,VCAN	EGF,EGFR,ERBB3,ERBB4,ERK1/2,ESR2,JUN,MYC,NFKBIA,NFkB (complex),P38 MAPK,PGR,RELA,SMAD3,STAT,STAT3,STAT5A,STAT5B,STAT5a/b,TP53	
P1	 	SP1	-0.096	transcription regulator	 	1.332	bias	0.436	-1.987	3.34E-13	ADAMTS1,ADRA1B,AEBP1,AKAP12,ALAS2,ALDH3A2,ALPL,APOE,ASNS,ASS1,ATF3,ATP2A2,BACE2,BMP4,BNIP3L,C1QBP,CAT,CAV1,CBS/CBSL,CCL2,CCND2,CCND3,CCNG2,CD55,CD59,CDH2,CDK4,CDKN2B,CDKN2C,CEBPD,CES1,COL1A1,COL1A2,COL7A1,COL8A1,CRABP2,CTGF,CTSD,CXCL12,CXCL8,CYC1,CYP11A1,CYP1B1,CYP51A1,DHCR24,DRG2,EGR1,ELANE,ESR1,FGF2,FLNA,FOLR2,FOS,GDF15,GSS,HADHA,HDC,HIF1A,HINT1,HMGA1,HMOX1,HSD11B2,HSPA5,ID4,IGFBP3,IGFBP4,IRF3,ITGAM,JUN,KDR,KIT,KLF4,LDLR,LHCGR,MAOA,MCL1,MEOX2,MMP2,MMP9,MYC,MYCN,MYH11,MYLK,NCF2,NDRG1,NFKBIA,NPTXR,NR5A2,P2RX7,PADI4,PKM,PLA2G4A,PLAA,PLAUR,POLD1,PRKCD,PRKCE,PROCR,PTGER4,PTGS2,PTTG1,RARA,RASGRP2,RNLS,SERPINE2,SGK1,SH3GL1,SLC11A1,SLC19A1,SLC2A3,SLC39A8,SLC4A2,SLC4A7,SLC7A1,SMAD7,SMPD1,SOX9,SPARC,SPP1,SRC,TAGLN,TFPI2,TGFBR2,TGFBR3,THBD,TIMP1,TIMP4,TNFAIP3,TNFRSF10B,TNFRSF4,TNFSF10,TRIB1,TXNRD1	AR,Ap1,CEBPB,CTNNB1,EGR1,ESR1,HDAC1,JUN,MYC,NFATC2,NFkB (complex),NOTCH1,Nfat (family),RELA,Ras,SIRT1,SP1,STAT1,STAT3,TP53,TP73,Vegf	
P1	 	Lh	 	complex	 	-0.368	 	0.138	-1.117	3.81E-13	ACP2,ACP5,ACTA1,ACTG2,ACTN1,ADAMTS1,ADGRG1,AKAP12,ALPL,ARHGEF5,ATP2A2,ATP2B1,ATPIF1,AXL,BNIP3L,CASP4,CCND2,CD55,CDKN1C,COL15A1,COL18A1,CXCL8,CXCR4,CYP11A1,DAB2,DHCR7,DHRS3,DUSP1,DUSP14,FLNC,FOS,FST,GBP1,GRK5,IL6,INHBB,ITGA3,LHCGR,MAP2K3,MAP4K4,MBD2,MCL1,MMP2,MMP9,MSMO1,NOL3,P4HA2,PAWR,PLAT,PPIH,PPP2R1A,PTGS2,PTPRE,PTPRF,PTX3,RAB5A,RANGAP1,RGS12,RGS16,RGS5,RHOB,RUNX1,SFRP4,SGK1,SH3BP4,SLIT2,STIP1,STK24,TFPI2,THBS1,TNFAIP3,TNFRSF12A,TPM1,TRIB1,TYRO3,UPP1,VEGFC	Akt,CREB1,CTNNB1,Cg,HIF1A,IL1B,ITGB1,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,STAT5a/b,TP53,prostaglandin E2	
P1	 	triamcinolone acetonide	 	chemical drug	 	-0.917	 	0.015	-1.037	3.88E-13	ALDH5A1,ANGPTL4,ANOS1,ATF3,ATP10A,BMP2,BMP4,BMP6,BTG2,CAPG,CASP4,CBX4,CYTIP,DDIT3,DGCR6/LOC102724770,DUSP1,DUSP10,EDNRA,EFNB2,EFS,EGR1,ELK1,FOS,GNAZ,HIPK2,IER2,IGFBP3,IGFBP4,ITGA10,JUN,JUNB,KLF9,LDLR,LSP1,MEGF9,MT1E,MT1F,MT1G,MT1L,MT1M,MT1X,MT2A,MXRA5,MYC,MYOC,NEK7,NFKBIA,NTM,PDIA5,PEX6,RGCC,RGS16,RUNX1,SAA1,SCNN1D,SEMA6A,SERPINA3,SFRP2,SLC31A2,SLC4A7,SOCS2,SPP1,SPRY1,SRGN,STC2,TACC2,TNFAIP8,TRIB1,ZNF263	Ap1,CTNNB1,EP300,HDAC1,JUN,Jnk,NFkB (complex),NOTCH1,NR3C1,RELA,STAT1,STAT3,Vegf,triamcinolone acetonide	
P1	 	OSM	-0.257	cytokine	 	-1.167	 	0.165	-2.966	4.33E-13	AADAC,ABCC1,ABCC3,ABCG1,ACKR2,ACSL3,ADAM17,ADAMTS1,AHCYL1,AKR1B10,AKR1C3,ANXA3,AQP9,ARHGEF2,ASNS,BAMBI,BLMH,C1R,CASP4,CAT,CCL2,CCND2,CCNG2,CDH2,CEBPD,CH25H,CHI3L2,CIZ1,CLIP1,CLPP,COL3A1,COL6A1,COL8A1,CTSH,CXCL12,CXCL2,CXCL8,CYP1B1,DHCR24,DHRS3,DNM1L,ECM2,EIF4EBP1,EMP3,EPHB6,ETS2,EVPL,FGF2,FOS,FOXC1,GBP1,GCA,GFPT1,GLUL,GPNMB,HBEGF,HIF1A,HLA-F,HMOX1,HOXA9,HP,HSD11B2,HSPA2,HSPA5,ID1,IGFBP6,IL6,IRAK1,ISG20,JUN,JUNB,KCNG1,KIF5B,LARGE1,LBP,LDLR,LITAF,LSM4,MAOA,MAPK7,MGMT,MKNK2,MMP2,MMP9,MPZL2,MSC,MT1X,MT2A,MYC,NEDD4L,NOMO1 (includes others),OLFML2A,PDCD4,PEPD,PFKFB3,PLA2G4A,PLLP,POMC,PTOV1,QSOX1,RAD23A,RNASE4,RUNX1,S100A8,S100A9,S100P,SAA1,SBF1,SELE,SERPINA3,SKIV2L,SLC7A8,SMPD1,SOCS3,SORD,STX11,TECR,TIMP1,TM4SF1,TM7SF2,TPM1,TPO,TSTA3,TUBGCP2,TULP3,TYMP,TYRO3,VCAM1,ZHX2,ZNF263,ZNF330	Ap1,ERK1/2,ESR2,FOS,IL6,IL6R,JUN,NFKBIA,NFkB (complex),OSM,P38 MAPK,RELA,SMAD3,SP1,SP3,STAT1,STAT3	
P1	 	PTEN	-0.306	phosphatase	 	-0.976	 	-0.031	-0.672	4.91E-13	ACACA,ACO2,ADIPOQ,ADM,AKR1C3,ALG3,ANGPT1,ARHGDIA,ASPH,ATP5G1,ATP5I,BTG1,BTG2,CA12,CA3,CBX4,CCND3,CDC20,CDH5,CDK4,CDKN2B,COX8A,CS,CSTF3,CTDSPL,CTSB,CXCL2,CXCL8,CXCR4,CYB561,CYP27A1,DRAP1,DUSP1,EDN1,EFNB2,EGR2,EIF4EBP1,EPAS1,ESR1,ETS1,FOS,G0S2,GCAT,GMDS,GPX3,GTPBP6,GYS1,HADHA,HIF1A,HSPA1A/HSPA1B,ID4,IFRD1,IGFBP3,IGFBP6,IL6,INPPL1,IRS2,KAT2A,KDR,KIF3B,KLF6,LIMS1,LZTR1,MBP,MCL1,MME,MMP2,MMP23B,MMP9,MRPL12,MT2A,MTOR,MVD,MYC,NDRG1,NDUFS3,NEU1,NOP2,NR4A2,NR5A2,PA2G4,PCBP2,PDCD4,PFKFB3,PFKL,PLEC,PLOD1,POLD2,PTGS2,PTPRK,RAD51D,RANGAP1,RUNX1,SBF1,SDC4,SFTPD,SLC20A1,SLC25A1,SMAD6,SMOX,SOCS3,SORD,SPP1,SPRY2,SRC,SUCLA2,TAF10,THBS1,TNFRSF14,TNFSF10,TRAPPC3,VAV3,VCAM1,VEGFC,WDR45	Akt,Ap1,CEBPA,CEBPB,ERK1/2,HIF1A,IGF1,JUN,NFKBIA,NFkB (complex),PI3K (complex),PTEN,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	genistein	 	chemical drug	Activated	4.475	 	0.144	3.056	6.52E-13	ACP2,ACP5,ADM,ADRBK1,AKR1C3,ALDH5A1,ANGPTL4,AP1B1,AP1S2,AP3B2,APEH,APOB,ARSA,ATP6AP1,ATP6V0B,BCL2L1,BIRC7,BMP2,BTG3,CAT,CCL2,CD4,CD68,CD86,CHEK2,CHPF,CLCN7,COL1A1,CTGF,CTNS,CTSA,CTSB,CTSD,CTSG,CTSH,CTSK,CXCL12,CXCL2,CXCL8,DNASE1L3,DNASE2,DNPH1,DUSP1,ERBB2,ESR1,FERMT3,FOS,FUCA1,GABARAP,GBA,GDF15,GFPT1,GJB2,GLB1,GLMP,GM2A,GUSB,HCST,HEXA,HIF1A,HMOX1,HS2ST1,HS3ST3A1,HSPA1A/HSPA1B,HSPA5,ID1,IDUA,IFIT2,IGF2R,IL6,JUN,JUNB,KCNJ2,LBP,LDLR,LGMN,MAL2,MAN2B1,MAOA,MCOLN1,MMP2,MMP9,MYC,NAGLU,NDST2,NEU1,PCDH17,PDCD4,PLA2G15,PLAT,PLBD2,PLCXD3,PLTP,POMC,PTGS2,RPN2,RRAGC,SGSH,SLC11A1,SLC1A5,SMPD1,SPP1,SQSTM1,TPP1,VCAM1,VPS52	ERK1/2,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,RAC1,RELA,SMAD3,SP1,SRC,STAT3,TFEB,genistein	
P1	 	gentamicin	 	chemical drug	 	1.834	 	0.123	0.766	7.16E-13	ACADM,ACSL3,ALAD,ALCAM,ALDH1A1,ALPL,ATF3,ATIC,ATP6V1D,AZIN1,BTG2,BTG3,CA4,CBS/CBSL,CCL2,CCNL1,CDC34,CDO1,CPEB1,CPSF2,CTSD,DDIT3,DECR2,EGR1,EIF3B,ENPP2,EXOC3,FMO1,GADD45A,GDF15,GJB2,GNL3,GSTM5,H3F3A/H3F3B,HMOX1,HSD11B2,HSPA1A/HSPA1B,HSPA5,HYOU1,IDH1,IFRD1,IGFBP3,JUN,JUNB,KLF6,LITAF,LOC102724828/MRPL23,MAF,MGMT,MYC,NCL,NME1,NR1D1,PC,PLIN2,PLLP,PPP1R1A,PSAT1,RBP4,RGCC,RPS27L,RUVBL1,S100A1,SLC22A5,SPP1,SQSTM1,ST6GALNAC3,TANGO2,TARS,TFRC,THY1,TIMP1,TSC22D1,TUBB,VAT1,VCAM1	Ap1,CAT,ESR1,FOS,Histone h3,JUN,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53,gentamicin	
P1	 	L-dopa	 	chemical - endogenous mammalian	Inhibited	-2.080	 	0.054	-2.752	1.04E-12	ADCK4,ADGRB2,ALPL,ARG2,ARHGAP4,ASPSCR1,ATP2A2,AXL,BANF1,C1GALT1C1,C1QA,C9orf114,C9orf24,CA12,CACNA1H,CAPG,CBR3,CCNG2,CDC42EP2,CEBPG,CHAC1,CIART,CINP,CLDN5,CMTM4,CMTM8,COCH,COMT,CORO2B,CRYM,CTSB,CXCL12,DAAM1,DBP,DCAF4,DCAKD,DDIT4L,DDOST,DGAT2,DPP7,DUSP1,EGR2,EIF4EBP2,EIF6,EPS15L1,ETS2,F11R,FAAH,FAAP100,FAM127A,FAM3A,FCGRT,FOS,FOSB,GABARAPL1,GAPDH,GLB1,GPC3,GPS1,GSTM1,GUCY1A3,HBEGF,HCST,HEXA,HRAS,IDO1,IER3,IFNAR2,IL11RA,ITGB1BP1,JUNB,KCNAB1,KCND2,KIAA1551,KLF6,KLF9,LAMP2,LMNA,LPP,MAPKAP1,MBP,MRPL48,MRPS21,MSMO1,MSRB1,MVB12A,NAGLU,NAV1,NEDD4L,NOL3,NOMO1 (includes others),NPM3,NPTX2,NTRK3,PA2G4,PALM2,PARM1,PCYT2,PDCD4,PDZD2,PKIA,PKP2,PLEKHA2,PLEKHO2,PPP1R1B,PQLC2,PTGIS,PTPRT,RAP1GAP,RASSF5,RBM6,RELN,RENBP,RERG,RILPL1,RNF135,RPUSD1,RUNDC3B,SCRN1,SERAC1,SH3PXD2B,SHC1,SIAH2,SLC22A17,SLC22A18,SLC25A44,SLC2A6,SLC8B1,SMUG1,SOBP,SORCS2,SOX9,SRM,SRPK3,SRPRB,STAB1,STXBP1,SYN1,SYN2,TAF9B,TAX1BP3,TLE1,TMEM106C,TMEM141,TMEM41B,TMEM63B,TNFRSF19,TRAPPC1,TRIB3,TRIOBP,TTYH1,UAP1L1,UBQLN4,UBXN6,VAMP1,VAT1,VTI1B	Ap1,CREB1,Creb,JUN,L-dopa,NFkB (complex),RELA,RPS6KA5,STAT1,STAT3,nitric oxide	
P1	 	tosedostat	 	chemical drug	Activated	2.878	bias	0.468	0.742	2.02E-12	ASNS,ASS1,ATF3,ATF5,CARS,CBS/CBSL,CCNG2,CHAC1,CXCL8,DDIT3,DDIT4,FYN,GADD45A,MARS,PPP1R15A,PSAT1,SARS,SESN2,STC2,TRIB3,WARS	 	
P1	 	pirinixic acid	 	chemical toxicant	Activated	2.035	bias	0.311	-0.928	2.29E-12	AADAC,ABCC1,ABCC3,ACACA,ACADM,ACADVL,ACAT1,ACAT2,ACOT4,ACSL4,ADH1C,ADIPOR2,AKR1B10,AKR1C3,ALDH3A1,ALDH3A2,ALDOC,ANGPTL4,APOE,AQP9,ASNS,BSG,CAT,CCL2,CCND3,CCT3,CD36,CDH2,CDK4,CIDEA,CIDEC,COL1A1,CTSB,CXCL12,CXCL8,CYP27A1,CYP2C8,DECR2,DNAJB2,ECI1,ELOVL3,ELOVL6,FBP1,FCER1G,FKBP1A,G0S2,G6PD,GADD45A,GADD45B,GAPDH,GBE1,GLUL,GOT1,GOT2,GPAM,GSTM3,HADHA,HIF1A,HIST1H1C,HMGCS1,HMOX1,HSD17B11,HSPE1,IL6,ITGAM,JUNB,KDR,KRT8,LDLR,LEP,LIG1,LPIN2,MAP3K8,MCL1,MMP9,MYC,NFKBIA,NR1D1,ORM1,PAICS,PCK2,PCSK5,PDCD4,PDK4,PERP,PFKL,PHLDA1,PLA2G2A,PLIN2,PLTP,POR,PSMA3,PSMA4,PSMB5,PSMB6,PSMB7,PSMD14,PTGS2,PTPRF,RTN4,SAA1,SLC16A5,SLC22A5,SLC27A1,STK36,TALDO1,TBCA,THRA,TUFM,TXN,UCP2,VCAM1,VEGFD	ATF6,Ap1,CEBPB,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,THRB,TNF,oleic acid,pirinixic acid	
P1	 	cycloheximide	 	chemical reagent	Inhibited	-2.463	 	-0.064	-1.870	3.90E-12	ADCY1,ADM,ADRA1B,ALDOA,APBB1IP,APOB,ASS1,BCL2L1,BIRC3,BTG2,BTK,CAT,CAV1,CCL2,CCL3L1,CCND3,CCR1,CD4,CD55,CEBPD,COL1A1,COL5A1,CTGF,CXCL2,CXCL8,CXCR4,CYP11A1,CYR61,DDIT4,DUSP1,EDN1,EGR1,ESR1,FGF2,FOS,FOSB,FST,GADD45A,GADD45B,GAP43,GBP1,GCLM,GNAI1,GOT1,HBEGF,HEXA,HMOX1,IGFBP4,IGFBP6,IL6,IRS2,ISG20,ITGAM,JUN,JUNB,KCND2,LARP6,LEP,LONP1,MCL1,MME,MMP2,MYC,MYCN,MYOC,NFKBIA,NQO1,OGN,PERP,PFKFB3,PLA2G2A,PLAT,PLAUR,PTGDS,PTGIS,PTGS2,PTX3,RCAN1,RERG,RHOB,S100A8,SELE,SOCS3,SPP1,TGFBR2,THBD,THBS1,THRA,TIMP1,TNFAIP3,TNFRSF10B,TNFSF10,TNIP1,TOB1,VCAM1,VHL,YME1L1	Ap1,ERK,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF,cycloheximide	
P1	 	Alpha catenin	 	group	 	-0.129	bias	-0.484	3.067	5.66E-12	ADAMTS1,AXIN2,BCL2L1,BIRC3,COL15A1,COL1A1,COL1A2,COL3A1,COL5A1,COL5A2,COL6A1,COL6A2,COL6A3,CTSB,CXCL12,CXCL2,EGFL6,ELN,GAP43,IGFBP4,IGFBP6,IL6,ITGAM,LAMA2,LUM,LYN,LYZ,MMP2,MMP23B,MMP9,MYC,NFKBIA,NFKBIZ,PTGS2,PTX3,S100A8,S100A9,SAA1,SELE,SGK1,SOCS3,TGM2,TIMP1,TNFAIP3,TNFRSF12A,VCAM1	APC,Alpha catenin,CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TCF	
P1	 	INHA	0.253	growth factor	 	-1.649	 	-0.010	-1.586	5.95E-12	ACTG2,ADAMTS1,ADAMTSL2,CCND2,CDK4,CNN1,COCH,COL1A2,COL3A1,COL4A5,COL6A1,COMP,CTGF,CYP11A1,CYP1B1,CYP51A1,CYR61,EMILIN2,EPHX1,F11R,FST,HSD17B11,IGFBP4,INHBB,ITGA3,KIT,KRT8,LAMC3,LHCGR,LMNA,MATN2,MMP2,MYC,MYH11,PCDH7,PRSS23,PTGS2,PTX3,SFRP4,SGK1,SMAD7,TJP1	CREB1,EGR1,FOS,FSH,INHA,INHBA,JUN,NFkB (complex),SMAD3,SMAD7,SP1,Smad	
P1	 	HIF1A	0.623	transcription regulator	 	-0.599	bias	0.362	-3.726	6.26E-12	ADAM17,ADAMTS1,ADIPOQ,ADM,AGT,AKAP12,ALDOA,ALDOC,ANGPTL4,APOE,AQP9,ASNS,ATG9A,ATP2A2,AXIN2,AXL,BCL2L1,BHLHE41,BMP2,BNIP3L,C9orf9,CARS,CAV1,CD24,CDH2,CTGF,CTPS1,CTSD,CXCL12,CXCL2,CXCL8,CXCR4,CYB5A,CYR61,EDN1,ENO1,EPAS1,ERBB2,ERGIC1,ETS1,FAM162A,FHL1,FOS,FSCN1,FZD2,GADD45B,GAPDH,GBE1,HES6,HIF1A,HIST1H1C,HIST2H2AC,HMGCL,HMOX1,HSPA4,HSPA5,IGFBP3,IL6,INHBB,IRS2,ITGA1,JUN,KIAA1217,KIFC2,LEP,LOX,MCL1,MGMT,MIF,MMP2,MMP9,MYC,NDRG1,NOTCH1,NOX4,NR4A3,P4HA2,PFKFB3,PFKL,PHLPP1,PKM,PLAUR,POLRMT,PTGS2,RET,SDC4,SESN2,SFRP1,SLC2A3,SMAD7,SOCS3,SOX9,SRD5A1,STC2,TAF9B,TFRC,TMEM19,TMEM79,VEGFC	AHR,ARNT,Akt,Ap1,CTNNB1,ERK1/2,ESR1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,SP1,STAT3,TP53,Vegf	
P1	 	CHUK	0.012	kinase	 	-0.006	bias	0.413	-3.113	6.79E-12	AEBP1,ATF3,BCL2L1,BMP2,CASP4,CCL2,CCL3L3,CCR1,CEBPD,CH25H,COL18A1,CTSB,CXCL12,CXCL2,CXCL8,CYBA,ENAH,ENPP2,FOS,GADD45B,GBP4,GM2A,GRN,HES6,HEY1,HEY2,HMOX1,IFIT2,IGFBP6,IL6,JUNB,MFAP5,MGP,MMP2,MMP9,MYC,MYH1,NAGLU,NFKBIA,NGF,NOTCH1,OGN,PCDH7,PLA2G4A,PLD3,PTGS2,PTX3,RCAN1,RGS16,SELE,SEMA3C,SERPINE2,SFRP1,SGK1,SLC16A2,SMOC2,SNX10,SOCS3,SPP1,SQSTM1,SRC,TNFAIP3,TNIP1,VCAM1,VEGFC	Ap1,CHUK,IKBKB,IKBKG,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,TP53	
P1	 	sirolimus	 	chemical drug	Inhibited	-4.060	bias	-0.298	-1.135	8.82E-12	ACACA,ACADM,ACADVL,ADM,ANXA5,ASNS,ASS1,ATF4,ATP5G1,BCL2L1,BEX2,BMP2,CCL3L3,CCND2,CCND3,CD209,CD86,CDK4,COL1A1,COL1A2,CRAT,CXCR4,DDIT3,DDIT4,DDT,DENND1A,DLG4,DVL3,EGR1,EIF5,ENO1,ERBB2,ERCC1,FOS,FSCN1,FTH1,G6PD,GAP43,H3F3A/H3F3B,HIF1A,HLA-DOA,HMOX1,HSPA4,HSPA5,ID1,IDH1,IL6,IRS2,JUNB,KDR,KLF2,LEP,LEPR,LMNA,LPIN1,MAF,MBP,MCL1,MMP2,MMP9,MTOR,MYC,MYH11,NCL,NDUFA9,NR4A3,ODC1,PDCD4,PKM,PLAUR,PLIN1,PLIN2,PRDX5,PRMT1,PRNP,PSMA3,PSMA4,PSMB6,PSMB7,PSME3,PYGB,RAN,RBM6,RCAN2,RPL34,RPL8,RPLP0,RPN2,RPS2,RPS21,RPS24,SLC1A5,SLC2A3,SLC3A2,SOCS3,SQLE,SQSTM1,SRC,SRSF3,TARS,THBD,TIMP1,TP53BP1,TSC2,TUBB2A,TUFM,UBA1,UCP2,VCAM1,VEGFD,ZFP36	CEBPA,CEBPB,D-glucose,ERK1/2,FOXO1,Growth hormone,HIF1A,Insulin,MTOR,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,STAT1,STAT3,TP53,sirolimus	
P1	 	cholesterol	 	chemical - endogenous mammalian	 	0.396	 	0.144	-0.686	1.10E-11	ABCG1,ACLY,AGT,APOB,APOE,AQP9,ATF3,ATF4,BSG,C1QC,CAV1,CCL2,CD14,CD1C,CD68,CNN1,COL1A1,COL3A1,CTSK,CXCL2,CXCL8,CYP27A1,DDIT3,DHCR7,EPHX1,FBXO3,FGF2,GBA,GNAI1,HBEGF,HES6,HMGCS1,HSPA5,IL10RA,IL6,ITGAM,LDLR,LEPR,LYZ,ME1,MMP2,MSMO1,MYH11,NCF2,NR4A2,NR4A3,PCYT2,PLTP,PSAT1,PTGS2,RGCC,RGS16,S100A8,SAA1,SLC1A3,SLC7A5,SOCS3,SQLE,STARD5,STX6,THBS1,TIMP1,TM7SF2,VCAM1,ZFPM2	APOE,Ap1,CTNNB1,IL1B,IL6,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,cholesterol	
P1	 	atorvastatin	 	chemical drug	 	-0.554	 	-0.063	-0.068	1.65E-11	ABCC1,ABCC3,ABCG1,ADIPOQ,APOB,APOE,BMP2,BMP6,CAT,CAV1,CCL2,CD36,CD55,CD59,CD69,COL1A1,CTGF,CXCL8,CXCR4,CYBA,CYP27A1,CYP51A1,CYR61,DHCR24,DHCR7,DUSP1,EDN1,EDNRA,EGR1,FOS,FOSB,GADD45B,GPAM,GSR,HMGCS1,HMOX1,IER3,IL6,JUN,JUNB,LDLR,LEP,LIPG,LSS,MMP2,MMP9,MSMO1,MVD,NOX4,PLAT,PRNP,PTGS2,RGS1,RHOB,RNU4-1,RNU4-2,SELE,SLCO2B1,SPP1,SQLE,TM7SF2,TMEM267,VCAM1,ZFP36	APOE,Ap1,CTNNB1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNF,atorvastatin	
P1	 	fluticasone	 	chemical drug	 	-1.478	 	0.012	-1.567	1.91E-11	ABCG1,ADM,ANGPTL4,AQP9,C1QB,CCL2,CCL4L1/CCL4L2,CCL8,CD163,CD36,CD4,CD86,CES1,CFB,CSF2RA,CXCL2,CXCL8,DDIT4,EMP1,FSCN1,GADD45B,GJB2,GSTM1,HLA-DOA,HLA-DRB4,HLA-F,IFI27,IL6,IRS2,KLF9,MMP9,MT1A,MT1X,MT2A,OLFML2B,OLFML3,PCOLCE2,PDK4,PHLDA1,PLIN2,RARRES1,RARRES3,RCAN1,RNASE1,S100A8,SDC4,SLC1A3,SLC2A5,SPP1,SPRY1,SRPX,TBC1D16,TGM2,THBS1,TIMP1,TSC22D1,VSIG4,WARS	EP300,FOXO1,HDAC1,HIF1A,Hdac,Histone h4,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT1,STAT3,STAT6,fluticasone	
P1	 	IL5	-0.037	cytokine	 	0.931	bias	0.476	-3.251	1.99E-11	ACP5,ALDOA,ALDOC,ASNS,ASS1,ATF4,BCL2L1,BNIP3L,CA4,CASP4,CCL2,CCL3,CCND2,CCND3,CCR1,CD24,CD55,CD69,CHMP1A,CKAP4,CRIP1,CSF3R,CXCL8,CXCR4,DUSP5,EGR1,EGR2,EGR3,EIF4EBP1,ENO1,FAM162A,FAM65B,GADD45A,GALK1,GBP4,GCAT,GCLM,GLIPR2,GPAM,HBEGF,HCAR3,HIF1A,HIGD1A,HSPA5,IER2,IER3,ITGAM,JCHAIN,KIAA1147,LUM,MMD,MMP9,MS4A2,MYADM,MYC,NABP1,NDRG1,PKM,PMP22,PSAT1,PYCR1,QSOX1,RAP1GAP,RASGRP2,RBPMS,RRAS2,SCRIB,SDF2L1,SGK1,SLC1A5,SLC39A8,SLC7A5,SNTB1,SOCS2,STK39,THY1,TMEM97,TNFRSF4,TUBB2B,UPP1	Ap1,CREB1,CSF2,ERK,IFNG,IL5,JUN,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	HGF	0.223	growth factor	 	-1.112	bias	0.366	-4.690	2.03E-11	ADAMTS1,ADGRF5,ADGRG1,AIMP2,AKAP12,ANGPTL4,ASNS,ATF3,BCL2L1,BIRC3,BMP2,CALCRL,CAV1,CCL2,CCNG2,CDC20,CDK4,CDKN2B,CDKN2C,COL1A1,COL1A2,COL3A1,CSE1L,CTGF,CTSK,CXCL2,CXCL8,CXCR4,CYR61,DDIT3,DDX11,DDX3X,DHPS,DKC1,DOK5,EDN1,EFNB2,EGR1,EMP1,ETS1,FANCG,FASTK,FLNA,FOS,FOSB,GBA,GPR4,GRB14,GRK5,HBEGF,HDGF,HK1,HMOX1,ID1,IGFBP3,IGFBP4,IL17RC,IL6,INPPL1,IRX5,ISG20,LDLR,LGMN,LRP8,LYVE1,MAP2K3,MAP3K8,MAPKAPK2,MCL1,MCM2,MEOX2,MMP2,MMP9,MYC,NID2,NOP2,NR4A2,NR4A3,NR5A2,NRP1,PHLDA1,PHLDA2,PKD1,PLAUR,PLOD1,PMP22,PPAN,PTGS2,PTPRF,PTTG1,PVR,RAB5A,RARRES2,RGS20,RHOB,S100A9,SFRP1,SGK1,SLC20A1,SLC7A1,SLK,SOCS2,SOCS3,SPP1,SPRY2,STAB1,STC1,TBC1D8,TGFBR2,THBD,THBS1,TIMP1,TJP1,TMEM158,TMEM97,TNFAIP3,TNFRSF10B,TRIB1,VCAM1,VEGFC	Ap1,ERK1/2,ETS1,HGF,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNF,VEGFA,prostaglandin E2	
P1	 	ANGPT2	-0.264	growth factor	Activated	3.480	bias	0.366	0.825	2.05E-11	ABCC1,ACTA1,ARHGEF2,AXIN2,C1R,CAT,CCL3L3,CD68,CDC34,CFB,COL1A1,COL1A2,COL3A1,COMT,CYBA,DBNL,DDIT3,DNAJB4,EDN1,EFR3A,ETS1,FKBP2,FKBP4,GSK3B,GSTT1,HIF1A,HMGCS1,HMOX1,HSPA1A/HSPA1B,HSPA2,HSPA4,HSPA5,IL6,KPNA2,LARP4,LEP,LEPR,LYN,MGMT,MIF,MMP2,MMP9,NME1,NOX4,PDCD4,PDIA5,PHLDA1,POLD1,PTGS2,RAD21,RCAN1,RHOB,SRXN1,TEK,TGFBR2,THBS1,TMEM41B,TNFRSF10B,TNFRSF12A,VCAM1,YIPF5	ANGPT2,Ap1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT3,TNF	
P1	 	U0126	 	chemical - kinase inhibitor	 	1.770	bias	-0.334	4.751	2.29E-11	ADIPOQ,ANGPTL4,APLNR,ARG2,ARHGEF2,ATF3,ATF4,AXIN2,BCL2L1,BIRC3,BMP6,CAV1,CCL2,CCL3,CCL3L3,CCND2,CCND3,CCNG2,CCNL1,CD36,CD69,CDH5,CEBPD,COL1A1,CSF1R,CTGF,CXCL2,CXCL8,CYP11A1,CYP1B1,DAB2,DBNDD1,DBP,DCHS1,DDIT3,DUSP1,DUSP10,DUSP5,EDN1,EEF1E1,EGR1,EGR3,EIF4EBP1,EMP1,ENPP2,ENPP4,ERCC1,ESR1,ETS1,ETV5,FAM53B,FGF2,FMO3,FOS,FOSB,G0S2,GADD45B,GAMT,GDF15,GFPT2,GRN,GSK3B,HBEGF,HIF1A,HMOX1,HSPA5,IDUA,IER2,IER3,IL6,ITGA3,JUN,JUNB,KDR,LAMP2,LDLR,LEP,LLGL1,MCL1,MMP2,MMP9,MYC,NNAT,NR4A2,NR4A3,NREP,PAWR,PHLDA1,PLA2G4A,PLAUR,PLIN1,PRELP,PTGS2,RUNX1,S100A9,SGK1,SLC2A3,SOCS3,SOX9,SPP1,SPRY1,STC1,STC2,TBCD,TF,TFPI2,TGFBR2,TGM2,THBS1,TMEM158,TPM1,TRIB1,TSC22D1,TSC22D4,TULP3,TYMP,VCAM1,ZFP36	EGF,ERK1/2,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF,TP53,U0126	
P1	 	INSR	-0.097	kinase	Activated	2.713	bias	0.337	0.647	2.32E-11	ACADM,ACADVL,ACO2,ACSL4,ACTA1,ALAD,ALDH2,ARHGDIA,ARHGEF2,ATF3,ATP5D,ATP5G1,C1QA,C2,CCL2,CCND2,CCNG2,CD36,CDKN2C,COL6A3,CORO2B,CRAT,CS,CSTB,CTGF,CTSB,CXCR4,CYC1,CYP1B1,CYP51A1,DHCR7,DUSP1,ECI1,EDN1,EGR1,EGR2,FBP1,FEM1A,FHL1,FLNC,FOS,GADD45A,GAPDH,GOT2,GRN,HADHA,HBEGF,HMGCS1,IDH1,IER2,IER3,IFNAR2,IGF2R,IL6,JUNB,KIT,KLF9,LEP,LEPR,LSS,LYZ,MAOA,MCM2,MMP2,MMP9,MRPS21,MSMO1,MVD,MYC,MYOM2,NDRG1,NDUFA9,NDUFB9,NGF,OGN,PDCD4,PDK4,PECR,PHLDA1,PHLDA2,RGS16,RHOB,SLC20A1,SOCS2,SOCS3,SQLE,SUCLA2,THRA,TK2,TOMM40,TSC22D1,UCP2,UQCRC1,VCAM1,ZNRD1	CEBPA,CEBPB,CREB1,D-glucose,ESR1,FOS,HIF1A,IGF1R,IGF2,INSR,Ins1,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,STAT3,STAT5a/b	
P1	 	RASSF1	0.254	other	 	-0.517	 	0.119	-1.225	3.43E-11	ALDH1A1,APOE,CARD8,CASP4,CAV1,CCND2,CDH2,CRABP2,CXCR4,DAB2,EFNB2,EGR1,EMP1,EPB41L3,ESR1,FGF2,FOS,GDF15,HBEGF,IGFBP3,KLF4,LITAF,MAP1B,MDK,MGMT,MMP2,MTUS1,MYC,PCDH7,PTGS2,SAMD5,SOX9,SPP1,SRPX,TGM2,TMEM158	ERK,ERK1/2,FOS,HIF1A,JUN,MAPK1,MYC,NFKBIA,NFkB (complex),RAC1,RASSF1,RELA,SMAD3,SP1,STAT1,STAT3,TP53,TP73	
P1	 	methylprednisolone	 	chemical drug	 	0.769	 	0.101	-0.250	5.00E-11	ABCC9,ADAM17,ADRA1B,AHCY,AK4,AKR1C3,ALAD,ALDH1A1,ALDH3A2,ANXA3,AP2A2,ASNS,ASS1,ATIC,ATP2A2,ATPIF1,AZIN1,BTG1,C1QB,C1QBP,CAMK1,CDH2,CIDEA,CLEC4F,COMT,CSNK2B,CST3,CTGF,CTSH,CYC1,DAB2,DDIT4,DHRS9,DNPH1,DUSP1,EIF3B,EMP1,ENPP2,EPHX1,FAAH,FARSA,FKBP4,FOS,G0S2,GADD45A,GCLM,GNL3,GOT1,GPC1,HACD3,HAGH,HMBS,HMOX1,HNMT,HSPA1A/HSPA1B,ID1,ID3,IDH1,IGF2R,IL6,ITGA7,IVD,JUN,KLF9,LDLR,LOX,LYVE1,ME1,MGMT,MGP,MIPEP,MMP9,MYC,NCL,NME1,NUPR1,ODC1,OPLAH,PAQR7,PC,PCYT2,PDE3B,PHLDA2,PKIA,PKP1,PLAA,PLAT,PLAUR,PLIN2,PLLP,PLS3,POR,PPOX,PRMT1,PSAT1,PSME2,PTER,RAB38,RABEP1,RAMP3,RGCC,RGN,RUVBL1,SDC4,SEPHS2,SERPINA3,SGK1,SLC19A1,SLC25A10,SLC2A3,SLC4A11,SLC4A7,SLC7A2,SLCO2A1,SNX1,SORD,SPARC,TFRC,TINAGL1,TNK2,TOB1,TRIM29,TUBA1C,TYRO3,VARS,VCAM1,ZFP36	AR,ARNT,ERK1/2,FOS,FOXO3,HIF1A,IL6,JUN,MAPK1,MYC,NFKBIA,NFkB (complex),NR3C1,NR3C2,PPARG,RELA,SMAD3,SP1,STAT1,STAT3,VHL,corticosterone,methylprednisolone	
P1	 	FAS	0.103	transmembrane receptor	 	-0.923	 	-0.073	-0.463	5.15E-11	ARFGAP1,ARHGDIA,BCL2L1,BIRC3,BTG3,BTK,CAST,CCL2,CCL3,CCL3L3,CCR1,CD59,CD86,CDC42EP2,CEBPD,CLTB,COL15A1,COL18A1,COL1A1,COL1A2,COL3A1,COL5A1,COL6A1,COL6A3,COL8A1,CTGF,CXCL2,CXCL8,DUSP10,EGR1,EGR2,ERCC1,FOS,FOSB,FSCN1,GBP1,GDE1,GPNMB,GRK5,GTPBP6,HCAR3,HLA-F,IER3,IL10RA,IL6,IMPA2,ITGA7,JUN,KIF3B,LAMP3,LDLR,LUM,MAP2K5,MAP4K4,MAPK7,MBOAT7,MGP,MIF,MME,MMP9,MYO5A,NFKBIA,NR4A2,ORM1,P2RX4,PDLIM7,PHLDA2,PIK3C2B,PLEC,PLIN2,PPFIBP2,PPP1R15A,PTGER4,PTX3,RAPGEF5,RARA,RASGRP2,RND2,RRAGD,SHC1,SIAH2,SORL1,SPP1,SPTBN1,TFRC,THBD,TLN2,TNFAIP3,TNFSF10,TNK2,TP53BP1,TPM1,TRIB1,VCAM1,ZFP36,ZP3	ERK,FAS,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TP53	
P1	 	ciprofloxacin	 	chemical drug	 	-1.406	 	0.009	-1.465	5.26E-11	ABCB6,ACO2,ACTN1,ALDH2,ALDH3B1,ATP6V1B2,ATP6V1D,ATP6V1E1,BMP4,CCR1,CD68,CD86,COLEC12,CPNE1,CTSA,CTSD,EMILIN2,GBA,GRN,GUSB,HSPA9,ITM2C,LDLR,LGMN,LONP1,MMP2,MTHFD1L,MYOF,NRP1,PLXNB2,RRAGC,RUFY1,RUVBL1,SHMT2,SLC2A6,SPP1,SRPRA,STAB1,STXBP1,TEX264,TTYH3,TUFM	 	
P1	 	MAP2K1	-0.184	kinase	 	0.291	bias	0.412	-2.264	7.14E-11	ABCC1,ADGRG1,APOE,ATF3,AXIN2,BCL2L1,BIRC3,CCL2,CCL3L3,CDH5,CDKN2B,COL1A1,COL1A2,COL3A1,CSTA,CTGF,CTSB,CXCL8,CYP11A1,DAB2,DUSP1,DUSP5,EGR2,ELK1,ENO1,ETV5,FGF2,FLNA,FOS,GUSB,HDC,HIF1A,HSPA5,IL6,JUN,LDLR,LEP,LHCGR,MBP,MMP2,MMP9,MYC,MYCN,NET1,NFKBIA,PLA2G4A,PLAUR,PTGS2,RAB38,RAP1GAP,RRAGD,SERPINE2,TFPI2,TGM2,THBS1,UNC5B	Ap1,EGR1,ERK1/2,ESR1,FOS,JUN,MAP2K1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	ADRB	 	group	Inhibited	-2.408	 	-0.174	-1.195	7.79E-11	ABL1,ACAT2,ADGRL4,ANGPTL4,ANXA5,ATF3,ATF5,AXL,BNIP3L,CASP4,CD68,CDK4,CXCL2,CYP51A1,DDIT3,DDIT4,FOS,GADD45A,GCLM,GDF15,HGH1,HMGCS1,HMOX1,IDH1,IKBKG,JUN,JUNB,KLF4,LPIN1,LSS,MMP9,MSMO1,MVD,NCL,NFKBIA,NPM3,NQO1,NR4A2,NR4A3,PCYT2,PKD1,RAN,SDPR,SLC6A9,SMAD6,SQSTM1,SRM,SRXN1,TEK	ADRB,Ap1,CREB1,Ca2+,ERK,FOS,JUN,JUNB,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	NR4A1	-0.119	ligand-dependent nuclear receptor	 	-0.658	 	0.044	-0.881	1.07E-10	ACACA,ACLY,ACSL4,ADIPOQ,ADIPOR2,ADM,AKR1C4,ALDOA,APOB,APOE,ATF3,AXIN2,BRE,CD36,CDH5,CIDEA,CLDN5,COL16A1,COL1A1,COL6A1,COL6A2,CRABP2,CXCL12,DDIT3,FBP1,G0S2,GSTM5,GYS1,HCAR1,HDC,HIF1A,HMOX1,IL6,KRT8,LDLR,LEP,LPIN1,LY6E,MMP9,NFKBIA,NR4A2,NR4A3,NUCB2,PDK4,PEBP1,PHKG1,POMC,PPP1R3C,PTGDS,RAMP3,SPINT2,TJP1,TNFSF10,UCP2,VCAM1	Akt,Ap1,CREB1,D-glucose,FOXO1,Growth hormone,HIF1A,Insulin,JUN,MYC,NFKBIA,NFkB (complex),NR4A1,POMC,PPARA,PPARD,PPARG,RELA,SREBF1,STAT3,TP53,fatty acid	
P1	 	IL4	0.092	cytokine	 	0.330	bias	0.293	-2.822	1.32E-10	ACP2,ACP5,ADRM1,ALDH1A2,ALDH2,ALDOC,ALG3,ANO1,APOE,APOLD1,APRT,ARG2,ASS1,B4GALT7,BCAT2,BCL2L1,BIN1,BNIP3L,BOP1,C5AR1,CAPG,CARM1,CCDC86,CCL13,CCL18,CCL2,CCL3,CCL3L3,CCL8,CCND2,CCND3,CCT3,CD14,CD163,CD163L1,CD1C,CD209,CD276,CD36,CD55,CD69,CD86,CELF2,CENPB,CLCN3,CLDN5,CLEC10A,CLEC4G,CLIP1,COBLL1,COL18A1,COL1A1,COL1A2,COL6A3,CRIP1,CSF3R,CTGF,CTNS,CTSK,CXCL16,CXCL2,CXCL8,CXCR4,EBNA1BP2,EGR2,EPHX1,F13A1,FAAH,FAM162A,FBL,FCER1G,FCER2,FCGR3A/FCGR3B,FLRT2,FNIP2,FOS,FOSB,GBE1,GCAT,GLIPR2,GNA15,GPM6B,HDDC2,HIPK2,HOMER2,HRSP12,HSPA1A/HSPA1B,IDO1,IER2,IER3,IFNAR2,IGFBP4,IL10RA,IL18RAP,IL6,ISG20,ITGA1,ITPA,JCHAIN,JUN,JUNB,KIT,KLF6,LAMP2,LIG3,LIPG,LPIN2,LSP1,MAF,MAOA,MARCO,MATK,MCL1,MMP2,MMP28,MMP9,MS4A2,MYC,NABP1,NCL,NDRG1,NEDD9,NFKBIA,NRP1,PAWR,PDE1B,PFKL,PIN1,PLIN2,PMP22,PRMT1,PRNP,PSMB10,PSMG1,PTGS2,RAB5A,S100A8,S100A9,SAMD4A,SDF2L1,SELE,SLC7A2,SMG7,SOCS2,SOCS3,SPHK2,SPINT2,SPP1,SQSTM1,SRM,STAB1,STUB1,SWAP70,SYT11,TFF3,TGM2,THBD,THOP1,THY1,TIMP1,TINAGL1,TLE1,TM7SF2,TMED5,TNFRSF4,UQCRC1,VCAM1,ZFP36	Ap1,CEBPB,FOS,IFNG,IL10,IL13,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,STAT6,TNF	
P1	 	CTNNB1	-0.268	transcription regulator	 	-0.729	bias	0.398	-3.638	1.53E-10	ABCC1,ACAP1,ADAM17,ADGRG2,ADIPOQ,AES,ALCAM,ALDH1A1,ALDH1A2,ALDH1A3,ALDH3A2,ALG3,AOC3,APCDD1,ARHGDIA,AXIN2,BAMBI,BCL2L1,BMF,BMP2,BMP4,C6,CA3,CAPNS1,CCND2,CD4,CDH2,CDKN2B,CIDEC,CLDN5,CNN2,COL1A1,COL4A5,CRABP2,CRAT,CRIP1,CTDSPL,CTGF,CTHRC1,CXCL12,CXCL8,CYB5A,CYP11A1,CYP51A1,CYR61,DDIT3,EDN1,ELOVL3,EMX2,ENPP2,EPHB3,EYA2,F13A1,FCER1G,FOS,FOXC1,FST,FZD7,GADD45B,GAP43,GIPC1,GJB2,GLUL,GNG10,GPR1,GTPBP6,HDGF,HSPE1,ID3,ID4,IDO1,IMPDH2,INHBB,ITGA1,ITSN1,JCHAIN,JUN,LHCGR,LMNA,LSP1,LY6E,MAN2B1,MCL1,ME1,MECOM,MME,MMP2,MMP23B,MMP9,MPZL2,MT1L,MYC,MYLK,NOTCH1,NR5A2,OGN,P2RX7,PCDH9,PFN1,PHLDA2,PKD1,PLAUR,PLS3,PMP22,PRKCSH,PTGS2,QPCT,RAD23A,RASSF5,RBP4,RCN1,RGN,S100A8,SAA1,SCAP,SCRN1,SEC61A1,SEMA3C,SERPINA3,SERPINE2,SFRP1,SFRP4,SGK1,SLC12A2,SLC1A5,SMAD6,SMAD7,SOX17,SOX7,SOX9,SPI1,SPP1,SQSTM1,STARD7,STXBP1,SYNM,TGM2,TIMP1,TJP1,TMEM2,TNFSF10,TSC22D1,UBA1,UBQLN4,VCAM1,VCAN,WNT5B,XAF1,ZFP42,ZP3	Akt,CEBPA,CEBPB,CREBBP,CTNNB1,Creb,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TCF,TNF,TP53	
P1	 	CEBPB	0.181	transcription regulator	 	0.104	bias	0.320	-2.816	1.77E-10	ADH1C,ADIPOQ,AGT,AKR1B10,AKR1C3,ALDH1A1,ALDH1A2,ANTXR1,APCDD1,APLNR,APOB,ASNS,B9D1,BCL2L1,CCL2,CCL3,CCL3L3,CCND2,CD14,CDKN2B,CDO1,CEBPD,CLPP,COL1A1,COL1A2,COL5A2,CSF1R,CSF3R,CXCL2,CXCL8,CXCR4,CYB5A,CYP11A1,DAB2,DDIT3,DGAT2,DHCR7,DYNLT1,EFNB2,ELANE,F8,FHL1,FOS,GADD45A,GLIPR2,GSK3B,HDC,HMGA1,HP,HSPA8,HSPE1,ID1,IER3,IGFBP3,IGFBP4,IL11RA,IL6,IRS2,JUN,LBP,LDLR,LEP,LEPR,LHCGR,LYN,MBP,MGP,MIA,MYC,NFE2L1,NFKBIZ,NRP1,NUPR1,ODC1,ORM1,PDK4,PEA15,PLA2G4A,PLAUR,POMC,PPP1R14A,PPP1R15A,PRKCD,PSMA3,PTGFR,PTGS2,SAA2,SFTPD,SGK1,SLC12A2,SLC7A1,SOCS3,SPP1,TF,TIMP4,TM4SF1,TNFRSF19,TRIB3,UPP1,VCAN	Ap1,CEBPA,CEBPB,ESR2,FOS,HDAC1,IL6,JUN,MYC,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	PTH	0.070	other	 	-1.148	bias	0.302	-2.915	1.86E-10	ADAMTS1,AHNAK,ANGPT1,ATP2A2,BMP2,CCL2,COL1A1,COL1A2,CTGF,CXCL12,CXCL2,CXCR4,CYBA,DUSP1,EFNB2,EGR2,ESAM,FOS,FOSB,ID4,IGFBP3,IL6,JUN,LIMA1,LMNA,LRBA,MGP,MME,MMP2,NR4A2,ODC1,PHLDB2,PPP1R1A,PPP1R1B,PTGS2,RAP1GAP,RGS1,RUNX1,SDC4,SFRP2,SFRP4,SMAD7,SOCS3,SPP1,SRC,STC1,TFPI2,THBS4,TJP2,TMEM119,TNS1	Akt,CEBPB,ERK1/2,HIF1A,IL6,JUN,NFKBIA,NFkB (complex),NR3C1,NR3C2,PTH,RELA,SMAD3,SP1,STAT1,STAT3,TP53,aldosterone,cyclic AMP	
P1	 	PPARA	0.146	ligand-dependent nuclear receptor	 	0.282	 	0.156	-1.109	2.03E-10	AADAC,ACACA,ACADM,ACADVL,ACAT1,ACAT2,ACTA1,ADIPOQ,AHCY,ALDH2,ALDH3A2,ANGPTL4,APOE,AQP9,ARHGDIA,ASNS,ASS1,BCKDK,C1QA,C1QB,C1R,C2,C6,CAT,CD36,CDK4,CDKN2C,CEBPD,CIDEA,CIDEC,CS,CSAD,CXCL12,CYBA,CYP27A1,CYP2C8,CYP51A1,DECR2,DHCR7,ECI1,EDN1,ELOVL3,ELOVL6,F11R,FOS,G0S2,G6PD,GLUL,GOT2,GPAM,GSTM3,H2AFZ,HADHA,HIF1A,HIST1H1C,HMGCS1,HMOX1,HSD17B11,IGFBP3,IGFBP6,IL6,KRT8,LIPG,LSS,ME2,MGMT,MMD,MMP9,MSMO1,MVD,MYC,NCF2,NFKBIA,NR1D1,PAQR7,PC,PDK4,PHLDA1,PLA2G2A,PLIN1,PLIN2,PLTP,POR,PTGS2,QPCT,RBP4,RTN4,SAA1,SERINC2,SLC27A1,SOCS2,SORD,SQLE,SRM,STIM1,TALDO1,TJP1,TMEM98,TPP1,TXN,UCP2,UQCRC1,VCAM1	CEBPA,CEBPB,FOXO1,JUN,NFKB1,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RXRA,SMAD3,SREBF1,STAT3,THRB,bezafibrate,fenofibrate,pirinixic acid	
P1	 	CSF3	-0.179	cytokine	 	0.354	 	0.130	-0.534	2.05E-10	ARHGDIA,BCL2L1,BIRC3,CAPG,CCL3,CCL3L3,CCND2,CCND3,CD14,CDK4,CSF3R,CST3,CTSD,CXCL12,CXCL8,CXCR4,EDN1,EGR1,EGR2,EGR3,ELANE,ENPP2,ERAP2,ETS1,FGFBP2,FOS,GADD45A,GADD45B,GPR183,GZMH,HDC,HLA-DRB1,HMOX1,IL6,ITGAM,JUN,KIT,LBP,LY96,LYZ,MMP2,MMP9,MYC,ODC1,PRKCE,RARA,RGS1,S100P,SOCS3,SPI1,TFRC,TNFAIP3,TNFSF10,VCAM1	Ap1,CSF3,IL6,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3	
P1	 	phorbol myristate acetate	 	chemical drug	 	-0.534	 	0.229	-3.549	2.19E-10	ACSL4,ACSM5,ADAM17,ADAMTS1,ADM,AGT,AHSA1,AKR1B10,ALDH1A3,ANGPT1,ANGPTL4,APRT,ATP2A2,AXL,BCL2L1,BIRC3,BMP6,BNIP3L,BTG2,BTK,C5AR1,CAPG,CAV1,CBS/CBSL,CCL18,CCL2,CCL3,CCL3L1,CCL3L3,CCND2,CCND3,CD14,CD163,CD209,CD276,CD36,CD4,CD55,CD68,CD69,CDK4,CDKN2B,CES1,CH25H,CIDEC,CRHBP,CSF1R,CSF2RA,CSTA,CTGF,CTSD,CXCL8,CXCR4,CYBA,CYP11A1,CYR61,DAB2,DBP,DDIT4,DUSP1,EDF1,EFNB2,EGR1,EGR2,EGR3,EIF4EBP1,EIF4EBP2,EIF6,ELANE,ELK1,ERBB2,ERCC1,ESR1,ETS1,ETS2,FAAH,FCER1G,FGF2,FOS,FOSB,FST,FTH1,GAP43,GDF15,GNAZ,GRK5,GSTM1,H19,HBEGF,HDC,HIF1A,HMBS,HMGA1,HNRNPK,HOXA9,HRAS,HSPA4,HSPA5,ID1,ID3,IGFBP3,IGFBP6,IL6,INHBB,IRAK1,ITGAM,ITM2A,JUN,JUNB,KAT2B,KIT,KLF2,KLF4,LARP4,LDLR,LEPR,LIPE,LTBR,LYVE1,LYZ,MAF,MCL1,METAP2,MME,MMP2,MMP9,MRPL12,MRPS12,MT2A,MYC,MYH1,NEU1,NFKBIA,NPR3,NQO1,NR4A2,NRP1,ODC1,PAQR7,PDCD4,PDE3B,PDK4,PEA15,PKM,PLA2G15,PLAT,PLAUR,PODXL2,POLR1C,POMC,PRKCD,PRKCE,PRNP,PTGDS,PTGER4,PTGFR,PTGS2,PTPRB,PTPRE,PTPRF,RAE1,RARA,RCAN1,RGN,RGS1,RUNX1,S100A8,S100A9,SELE,SERPINA3,SFRP2,SLC11A1,SLC12A2,SLC7A1,SMPD1,SOCS3,SPARC,SPP1,SRC,SRGN,SRXN1,STC1,STK40,STX1A,TEF,TFPI2,THBS1,THRSP,THY1,TIMP1,TJP1,TJP2,TNFAIP3,TNFRSF12A,TNFSF10,TPO,TUFM,TYMP,VCAM1,VCAN,VEGFC,VSIG4,ZFP36	EGF,ERK1/2,IFNG,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TNF,TP53,phorbol myristate acetate	
P1	 	LDL	 	complex	 	0.640	bias	0.253	-1.135	2.82E-10	ABCG1,APOE,ARG2,ATF3,ATP2A2,AXL,BCL2L1,CAPN2,CBS/CBSL,CCL2,CCL3,CCL8,CD36,CD68,CDH5,CLIP2,CTGF,CTSK,CXCL2,CXCL8,CYP2C8,DDIT3,DUSP1,EGR1,EGR3,ERBB2,FOS,FOSB,G0S2,GCLM,GNAI1,GPR183,HIF1A,HMOX1,HSPA5,HYOU1,IDO1,IFIT2,IGFBP3,IGFBP4,IL10RA,IL6,ITPR2,JUN,LDLR,LIMS1,MCL1,MMP2,MMP9,MSC,NME1,NR4A2,NR4A3,PLAT,PLIN2,PTGS2,PTPRF,RABEP1,RARA,RCAN1,S100A8,SELE,SHC1,SOCS3,TGFBR2,TGFBR3,TNFAIP3,VCAM1	CREB1,FOS,IL1B,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TNF,lipopolysaccharide,prostaglandin E2	
P1	 	decitabine	 	chemical drug	 	-1.558	bias	0.380	-5.332	3.12E-10	ABCC1,ABCC3,ADRB2,AKAP12,ALDH1A2,ANGPTL4,APOE,BIRC3,BMP4,BTG1,BTG3,CAV1,CCND2,CCND3,CCNG2,CDH2,CDKN1C,CDKN2B,CHFR,CLDN5,COL1A1,COL1A2,COL3A1,COL6A3,COL7A1,COMT,CTGF,CXCR4,CYP11A1,CYP1B1,CYP4B1,DEFB1,DNAJC15,DNASE1L3,DUSP1,EEF1G,EGFL6,EGR3,EPHB6,ESR1,FAM127A,FBN2,FECH,FLNC,GADD45B,GDF15,GLB1,GLRX,GPC3,H19,HBEGF,HOXA9,HSPA1A/HSPA1B,IFI27,IFIT2,IGFBP3,IL6,ING1,ITGA1,ITGA3,JUNB,KLF4,KLF6,KRT8,LAMA2,LDLR,LEPR,LOX,LUM,LXN,LY96,MAF,METAP2,MGMT,MIB2,MMP2,MMP9,MYC,NDRG1,NFKBIA,NME1,NPTX2,NQO1,PAWR,PCDH9,PKP2,PLCE1,PTGS2,RARRES1,RASSF5,RELN,RNASE4,RPL9,RRM2B,SERPINH1,SFRP1,SGK1,SLC19A1,SLC22A17,SLC2A3,SOCS3,SPARC,SPI1,SPINT2,SPP1,TFPI2,TFRC,TGFBR2,THBD,THBS1,TJP2,UBA1,UCHL1,VCAN	Ap1,CEBPA,CEBPB,EGR1,ESR1,HIF1A,JUN,MAX,MYC,NFkB (complex),RELA,SMAD1,SMAD3,SMAD4,SP1,STAT1,STAT3,Smad,TGFBR2,TP53,TP73,decitabine	
P1	 	JUN	-1.846	transcription regulator	 	0.788	 	0.250	-0.977	3.14E-10	ACAT2,ACP5,AKAP12,APOE,ASNS,ATF3,AXL,BIRC3,BTG1,CA3,CAPN2,CAPNS1,CAV1,CCL2,CCL8,CCND2,CCND3,CD14,CD68,CDC20,COL1A1,COL1A2,COMT,CSF1R,CSTA,CTGF,CXCL16,CXCL8,CYGB,CYP11A1,CYP1B1,DUSP1,EDN1,ERCC1,FGF2,FLNC,FOLR2,FOS,FOXC1,FRZB,FTH1,GAP43,GOT1,GSK3B,HLA-G,HMGA1,HMOX1,IGF2R,IGFBP3,IGFBP4,IL6,IRS2,ITGAM,JUN,JUNB,LAMP2,LBP,LHCGR,LMNA,LPAR1,MBP,MMP2,MMP9,MT2A,MVD,MYC,NCF2,NFKBIA,NFKBIZ,NGF,NQO1,NR5A2,PADI4,PARVA,PEA15,PLA2G4A,PLAUR,PRKCE,PTGDS,PTGS2,PTX3,RARA,RGN,RHOB,SAA1,SF3B3,SFTPD,SGK1,SLC19A1,SLC7A1,SMAD7,SOCS3,SPARC,SPP1,STIM1,SULF2,THBS1,TIMP1,TXN,VAV3,VCAM1,XPO5,ZFP36	Ap1,EGR1,ESR1,ESR2,FOS,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,STAT1,STAT3,TNF,TP53	
P1	 	HTT	0.065	transcription regulator	Activated	2.253	 	0.103	1.747	4.41E-10	ACADM,ACAT2,ACTA1,ADRBK1,AGT,AKAP12,ALDOA,ALDOC,ASGR1,ATF3,ATP2A2,ATP2C1,ATP5G1,ATPAF2,AZIN1,BTG3,C1R,C2orf40,CA12,CA4,CANX,CAST,CBX1,CBX5,CLOCK,COCH,COL16A1,COL18A1,COL6A1,COL6A3,CORO2B,COX15,CPSF2,CSF1R,CTGF,CTSD,CYC1,CYP51A1,DBNL,DBP,DDIT3,DHCR7,DKK3,DLG4,DPM2,DUSP5,EBF1,ECI1,EGR1,EGR2,EMP3,ENPP2,EPB41L3,FAM173A,FHL1,FKBP4,FOS,GAP43,GAPDH,GKN1,GLUL,GPC1,GPX3,GRK5,GSR,GSS,HBEGF,HIF1A,HMGA1,HMGCS1,HRAS,HSPA5,HSPA8,HSPA9,HSPE1,IL11RA,JUN,JUNB,KAT2A,KCNAB1,KCNJ2,KCNK3,KLF4,KLF9,LDLR,LOX,LTBP2,MCAM,MFAP4,MGP,MICU1,MLF2,MMP2,MTOR,MYH1,NDUFA7,NDUFS3,NDUFS7,NR4A2,NREP,NSF,P2RX7,PC,PDE1B,PEA15,PFN1,PLAUR,PLOD3,POR,PPP1R16B,PPP1R1A,PPP1R1B,PPRC1,PRELP,PRKCD,PTPN23,RAP1GAP,RARA,RASGRP2,RBP4,RGS16,SERPINA3,SERPINH1,SFRP1,SGK1,SGTA,SLC12A2,SLC1A3,SLC25A22,SOCS2,SPP1,SQSTM1,SRM,STRN4,STX1A,STXBP1,SYN1,SYN2,TAGLN,TFRC,TGM2,THRA,THRSP,TM4SF1,TRAP1,TUBB,TYRO3,UCHL1,VAMP1,VAPA,VCAM1,VEGFD,VTI1B	APP,Ap1,CREB1,Ca2+,EGR1,ESR1,HIF1A,HTT,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,TP73	
P1	 	thioacetamide	 	chemical toxicant	 	1.812	bias	0.423	-0.410	5.20E-10	ACP5,ADAMTS1,AKAP12,AKR1C3,ARG2,ASNS,BIRC3,CAPN6,CD14,CD55,CIDEC,CLIP2,COL1A1,COL1A2,COL3A1,CPA3,CTGF,CYGB,DKK3,ELMOD3,ELN,EMP1,EMP3,EPHX1,ERBB2,FCER1A,GDE1,GNG11,GOT1,GPNMB,GPX3,GSTM3,HK1,HSPA4,IER3,IGFBP3,IL6,ITGA7,JUN,LOX,LRP8,LXN,LYVE1,MMP2,MS4A2,MYC,NLGN1,NUPR1,ODC1,PCOLCE,PDGFD,PIK3R2,PKM,PMP22,POR,PRELP,PSMB10,PTGS2,RCN1,RGCC,SLC22A5,SMAD7,SPARC,SPP1,TAGLN,TGM2,TIMP1,TNFRSF12A,TYRO3,UPP1	HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TNF,adenosine,reactive oxygen species,thioacetamide	
P1	 	VHL	0.531	transcription regulator	 	0.359	 	-0.195	1.152	5.74E-10	ADGRG1,AHCYL1,ALDH1A1,ATF4,BCL2L1,CA12,CAV1,CDH2,CDKN1C,CNN1,CTGF,CXCL12,CXCR4,DAB2,EIF5,EPAS1,FAF1,FLCN,FTH1,GBE1,HIF1A,HMOX1,HYAL1,IER3,LMNA,MAF,MIF,NEDD9,NOSIP,NOX4,NREP,PFKFB3,POLRMT,PPIL1,PREB,QPRT,RUNX1,SLC1A3,SPARC,TAGLN,TFRC,TMED3,TNFSF10,VEGFC	ARNT,Ap1,CTNNB1,CXCR4,EPAS1,ESR2,ETS1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,STAT3,VEGFA,VHL	
P1	 	Jnk	 	group	 	-1.652	bias	0.363	-4.186	6.09E-10	AGT,ALDH1A2,ANXA5,ATG7,BCL2L1,BIRC3,BMF,BTG1,CCL2,CCL3,CD209,CD55,CD69,CD86,CDH2,CDK4,CELF2,CLEC10A,COL1A1,COL3A1,CTGF,CXCL12,CXCL8,CXCR4,DDIT3,DUSP1,EDN1,EGR1,ETS1,FOS,FOSB,GADD45A,GAP43,GDF15,HMOX1,HSPA5,IL6,JUN,KLF6,MMP2,MMP9,MYC,NOX4,NQO1,PLAT,PLAUR,PTGS2,RARA,SELE,SESN2,SOCS3,TGFBR2,TGM2,TIMP1,TNFRSF10B,TNFRSF12A,VCAM1,VCAN,ZFP36	Ap1,ERK1/2,FOS,IL1B,JUN,Jnk,MAPK8,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF	
P1	 	ERK	 	group	 	-0.611	bias	0.319	-3.038	6.12E-10	ACP5,ACTN1,AGT,ARG2,BCL2L1,BMF,BTG2,BTG3,CAV1,CCL2,CCND3,CCR1,CDK4,CEBPD,COL1A1,COL3A1,CTGF,CTSK,CXCL2,CXCL8,DUSP1,EDN1,EGR1,EGR2,ETS1,FGF2,FOS,FST,GDF15,GOT1,GPRC5C,HBEGF,HEY1,HEY2,HMGA1,HMOX1,IER3,IFNAR2,IL6,ITGAM,JUN,JUNB,LDLR,MAP4K4,MCAM,MCL1,MMP2,MMP9,MYC,MYLK,NDRG1,NFKBIZ,ODC1,OSBPL10,PDK4,PTGS2,SLC4A7,SPTBN1,TGM2,THBS1,TIMP1,TNFAIP8,TNFRSF10B,TYMP,VCAN,ZFP36	Akt,CEBPA,CEBPB,ERK,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TNF,TP53	
P1	 	PI3K (complex)	 	complex	 	1.310	bias	0.338	-1.167	7.15E-10	ADRB2,ATF3,ATF4,BCL2L1,BIRC3,CCL2,CCL3,CCND2,CCND3,CCNG2,CCR1,CD55,CD86,CDH2,CDK4,CDKN2B,COL1A1,CTGF,CTSD,CXCL8,CXCR4,DDIT3,DUSP1,ETS1,FOS,G6PD,GAP43,GCLM,GSTM5,H19,HBEGF,HIF1A,HIF1AN,HK1,HMOX1,IL6,ITGAM,JUN,KDR,KLF2,LEP,LHCGR,LSP1,LTBP2,MCAM,MCL1,MMP2,MMP9,MT2A,MTHFD2,MYC,NCL,NFKBIA,NME1,NOTCH1,NOX4,NQO1,NR4A2,NUPR1,PDCD4,PIN1,PLA2G5,PPP1R1B,PTGS2,RHOB,SGK1,SLC9A1,SOCS3,SOX9,SPI1,SPP1,TGM2,THBS1,TNFSF10,TYMP,VCAM1	Akt,Ap1,EGR1,ERK1/2,HIF1A,JUN,Jnk,LY294002,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,STAT3,TNF,TP53	
P1	 	NFkB (complex)	 	complex	 	-1.300	bias	0.447	-5.742	7.22E-10	ABCG1,ADRA2A,AGT,ALDH1A3,ALDH1B1,AMPH,APOE,ATF3,ATP2A2,BAMBI,BCL2L1,BEX2,BIRC3,BMP2,C1R,CAMK2D,CAPNS1,CARD8,CASP4,CBR3,CCL2,CCL3,CCL3L1,CCL3L3,CCL8,CCND2,CD36,CD69,CD86,CEBPD,CFB,CLIP2,COL18A1,COL1A2,CTGF,CXCL12,CXCL2,CXCL8,CXCR4,CYR61,DBP,DDIT3,DOK5,DUSP5,DVL3,EDN1,EGR1,ELK1,ERAP2,ERBB2,ETS1,FAM46A,FCER2,FGF2,FOS,FST,FTH1,FUCA1,G0S2,GADD45A,GADD45B,GDF15,GFPT2,GRK5,HDGF,HIF1A,HLA-F,HMOX1,HSPA9,IDO1,IER3,IFNAR2,IL10RA,IL6,IRF3,ITGAM,JUN,JUNB,KDR,KIT,LAMP2,LITAF,LSP1,MAP3K8,MCL1,MMP2,MMP9,MTSS1,MYC,MYLK,NCF2,NCOA7,NFKBIA,NFKBIZ,NGF,NOTCH1,NR1D1,ODC1,PEA15,PKP1,PRKCD,PTGS2,PTX3,RGS16,RRAS2,RUNX1,SAA1,SDC4,SELE,SERPINA3,SLC2A5,SLC2A6,SLC7A1,SLC7A5,SLIT2,SMAD7,SOCS3,SPP1,STIM1,TFPI2,TFRC,TGM2,TIMP1,TNFAIP3,TNFAIP8,TNFRSF10B,TNFRSF4,TNFSF10,TNIP1,TPO,TRIB3,VCAM1,VEGFC,ZFP36	HIF1A,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53	
P1	 	MKNK1	0.090	kinase	 	1.947	bias	0.501	 	9.59E-10	ACOT7,ANXA5,AP3D1,ATAT1,CYR61,EPB41L2,ETS1,FAM49A,FLNA,FOS,FOSB,GAP43,GNAI1,GPC4,GPS1,HADHA,HSPA2,IFIT2,IFRD1,MAP1B,MAPK8IP3,MYC,MYO5A,NCDN,NR4A3,PLTP,PLXNB2,RNH1,SERPINH1,SFRP1,SPARC,STRN4,STXBP1,SYN2,TAGLN,THRA,TP53BP1,TPP1	 	
P1	 	RAF1	0.240	kinase	 	-0.825	bias	0.437	-4.061	1.04E-09	ACAT2,ACOT7,AKAP12,BTG1,CDKN2B,CHN1,CSTA,CTSH,DHRS3,DUSP5,EGR1,EGR3,ELK1,EMP1,EMP3,ERBB2,ESR1,FOS,GRN,HBEGF,HDC,HIF1A,HSD11B2,ID3,IER2,IER3,IGFBP3,IL6,ITGAM,JUN,KIAA0391,LPGAT1,MMP9,MT1F,MT1L,MT1M,MYC,NGF,NINJ1,PC,PHLDA1,PHLDA2,PLAT,PLAUR,PLEC,PTGS2,RAN,RET,RGS1,RPS2,SPRY2,SQLE,ST3GAL4,ST6GALNAC2,TFPI2,TGM2,TIMP1,TOMM40,TSC22D1,TUBB2A,TUBG1,ZFP36L2	CEBPB,ELK1,ERK1/2,FOS,HRAS,JUN,MAP2K1,MAPK3,Mek,NFKBIA,NFkB (complex),RAF1,RELA,SMAD3,SP1,SRF,STAT1,STAT3,TP53	
P1	 	PI3K (family)	 	group	 	0.621	bias	0.254	-0.806	1.10E-09	ABCG1,ADM,AKR1B10,ATG7,BIRC3,CCL2,CCND3,CCNG2,CDKN2B,CTSD,CXCL12,CXCL8,CXCR4,DDIT3,ESR1,FOS,GCLM,HIF1A,HK1,HMOX1,HSPA5,IL6,KLF2,LEP,MMP9,NQO1,PKM,PTGS2,SIAH2,SLC4A7,TJP1,TNFRSF10B,TNFSF10	AKT1,Akt,Ap1,EGR1,ESR1,GSK3B,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (family),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	halofuginone	 	chemical drug	Inhibited	-2.778	bias	-0.371	-1.510	1.39E-09	ACP5,AKAP12,CD55,CLIP2,COL1A1,COL1A2,CPA3,CTGF,CTHRC1,CYGB,DKK3,EGR1,ELN,EMP1,EPHX1,FCER1A,GDE1,GNG11,GOT1,GPX3,H19,HK1,HSPA4,IGFBP3,ITGA7,LOX,MMP2,MMP9,MS4A2,NLGN1,NUPR1,PCOLCE,PIK3R2,PKM,PMP22,POR,PRELP,RGCC,SMAD7,SPARC,SPP1,TAGLN,TGFBR2,TGM2,TIMP1,TYRO3	Ap1,CEBPA,CEBPB,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TP53,halofuginone	
P1	 	EDN1	-1.046	cytokine	 	-1.245	bias	0.394	-3.954	1.40E-09	ACTA1,ADIPOQ,ANXA5,ATF6,ATP2A2,CALCRL,CDH2,COL1A2,COL5A1,COL7A1,COMP,CST3,CTGF,CXCL8,CXCR4,CYP11A1,EDN1,EDNRA,EGR1,FGF2,FOS,FOSB,FST,GRN,HEY1,HIF1A,HSPA5,HSPA8,IL6,ITGAM,ITPR2,JUN,JUNB,LEP,LEPR,MBP,MCAM,MMP2,MMP9,MYC,NUPR1,ODC1,PLAUR,PLOD1,POMC,PRKCD,PRKCE,PTGER4,PTGS2,RAMP3,SELE,SOCS3,TGM2,THBS1,TIMP1,VCAM1,VCAN,VEGFC	Ap1,CEBPA,CEBPB,EDN1,ERK1/2,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TP53	
P1	 	TREM1	-0.125	transmembrane receptor	 	-1.267	bias	0.266	-3.297	1.46E-09	ACSL3,ADRB2,ARRDC4,ASNS,ASPH,ATF3,BRE,CCL18,CCL3,CD14,CD86,CDKN2B,CFB,CXCL2,CXCL8,CXCR4,DUSP14,EDN1,EGR1,EGR2,EGR3,ETS2,GADD45B,GCLM,HBEGF,HES4,IDO1,IFIT2,IL6,KANK1,KCNJ2,LAMP3,LRFN4,MAP3K8,MT1E,MT1F,MT1M,NEDD4L,NFKBIA,NR4A2,OSGIN1,PHLDA1,PHLDA2,PTGS2,RCAN1,RGS1,RGS16,RHOU,S1PR3,SLC1A3,SNUPN,SPP1,SPRY2,TBC1D7,TCEAL9,TFPI2,THBD,THBS1,TMEM158	ELK1,FOS,IL1B,IL6,JUN,MAPK1,MAPK3,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TREM1	
P1	 	1,2-dithiol-3-thione	 	chemical reagent	Activated	5.368	bias	0.371	2.489	1.54E-09	ABCC3,AKR1B10,ALAS2,ALDOA,ANG,APBA3,CCT3,CDC34,CLPP,CTSD,DHCR7,DNAJB11,EIF3C,EIF6,EPHX1,ERP29,ETV6,FMO1,FTH1,GBE1,GCLM,GNA11,GSPT1,GSR,GSTM1,GSTM5,HACD3,HAX1,HMBS,HMOX1,IKBKG,LMNA,LY6E,MRPS18B,MSMO1,NARS,NQO1,NUCB2,P2RX4,PSAT1,PSMA4,PSMB2,PSMB5,PSMB6,PSMD14,PSMD7,RAN,RPLP0,RUVBL1,SAA1,SEC61A1,SERPINA3,SLC16A2,SLC35B1,SRXN1,STIP1,TFRC,THRSP,TMED2,TXN,TXNRD1	1,2-dithiol-3-thione,BACH1,NFE2L2,NFKB1,NFkB (complex),RELA	
P1	 	mifepristone	 	chemical drug	 	1.350	 	-0.097	2.173	1.71E-09	ABCC3,ADM,AKR1C4,ALPL,APOE,ATF3,BCL2L1,C1QB,CAV1,CCL2,CD14,CEBPD,CLEC3B,COL15A1,COL18A1,COL5A2,CTGF,CTSD,CYBA,DDIT4,DKK3,DUSP1,EFNB2,EGR1,EGR2,EPHB3,FGF2,FOS,FST,FTH1,GSTM1,H6PD,HBEGF,HDC,HSPA4,HSPA5,IGFBP3,IL6,INHBB,IRS2,ITGAM,JUN,JUNB,KIT,KLF4,LAMA2,LDLR,LOX,MME,MMP9,MYC,NDRG1,NFKBIA,NOX4,NPL,NPM3,OGN,P2RX7,PC,PEPD,PFKFB3,PLAT,PTGIS,PTGS2,RAMP3,RARA,RELN,RHOB,SFRP2,SFRP4,SOX17,SPP1,SRM,TENM3,TNFRSF10B,VCAN	Ap1,CEBPB,EGR1,ERK,ERK1/2,ESR1,ESR2,JUN,NFKB2,NFKBIA,NFkB (complex),PGR,RELA,SMAD3,SP1,STAT3,TP53,dexamethasone,mifepristone,progesterone	
P1	 	IL6	-3.152	cytokine	 	-1.748	bias	0.262	-4.548	1.82E-09	ABCC1,ABCC3,ACKR2,ADAMTS1,ADRBK1,AGT,AHNAK,ANG,APOB,APOE,ATF3,ATP2A2,AXIN1,BCL2L1,BMP2,BMP6,BTG2,C5AR1,CAPRIN1,CCL2,CCL3L1,CCL3L3,CCR1,CD14,CD163,CD163L1,CD209,CD36,CD68,CD86,CDC20,CDKN2B,CEBPD,CES1,CES2,COL1A1,COL3A1,CSF3R,CST3,CTGF,CTSK,CXCL2,CXCL8,CXCR4,CYP1B1,CYP2C8,CYTIP,DUSP1,EGR1,EGR2,ELANE,ENPP2,ETS2,FCER2,FCGRT,FGF2,FOS,FSCN1,GADD45A,GADD45B,GALE,GLRX,HIF1A,HMOX1,HOMER3,HP,HSPA5,ID1,IDO1,IFIT2,IGFBP3,IGFBP4,IGFBP6,IL17D,IL17RC,IL6,ITGAM,JCHAIN,JUN,JUNB,KCTD13,KDR,KIT,KRT8,LARGE1,LBP,LDLR,LEP,LHCGR,LIG1,LYZ,MAF,MCL1,MMP2,MMP9,MTOR,MYC,NCF2,NFKBIA,NGF,NOTCH1,NUCB2,ORM1,PLA2G2A,PLAT,POLD1,POMC,PPP1R15A,PPRC1,PRNP,PRPH,PSMB10,PSME2,PTGER4,PTGFR,PTGS2,PTTG1,ROR1,S100A9,SAA1,SAA2,SAA4,SERPINA3,SGK1,SH3GLB1,SLC12A2,SMAD7,SMOX,SNX10,SOCS2,SOCS3,SP110,SPI1,SPP1,SRC,STOM,SV2B,TF,TFRC,TGM2,THBS1,THRSP,TIMP1,TMEM8B,TNFRSF10B,TNFSF10,VCAM1,WARS,WASF3,XPNPEP2	CEBPA,CEBPB,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,TP53	
P1	 	tunicamycin	 	chemical - endogenous non-mammalian	 	0.945	 	0.220	-0.522	1.96E-09	ADIPOR2,ASNS,ATF3,ATF4,ATF6,ATP2A2,AXL,BIRC3,CANX,CASP4,CCND3,CD36,CHAC1,CLDN5,COL1A1,CXCL2,DDIT3,DDIT4,EDEM1,EGR1,ETS1,GADD45B,HMOX1,HSPA5,HSPA9,IL6,KLF4,LONP1,LPIN1,MCL1,MMP9,MYC,NDRG1,NFKBIA,PCK2,PHLDA1,PLIN2,PRNP,PTGS2,PVR,SDF2L1,SEC61A1,SESN2,SIGMAR1,STARD5,TJP1,TNFRSF10B,TPO,VCAM1	ATF6,ATF6B,Ap1,Creb,DDIT3,EIF2AK3,FOXO1,FOXO3,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53,XBP1,tunicamycin	
P1	 	DICER1	-0.318	enzyme	 	1.383	 	-0.115	2.066	1.99E-09	ACVR1C,ANGPTL4,CAMK2D,CCND2,CDKN2B,CHD7,COL18A1,CRYM,CXCL8,CXCR4,CYR61,DHCR24,DLG4,EGR1,EGR2,EGR3,ERBB2,FOS,GNG2,H19,ID3,IGF2BP2,IGF2R,JUN,KDR,LIPG,MAF,MMP9,MT2A,MTOR,MYC,NANOS1,NOTCH1,PBX3,PMP22,PRKCD,PROCR,RAD23A,RANGAP1,RBM38,RET,RGCC,RGS5,RTN1,RUNX1,S1PR1,SERTAD4,SFRP4,SOCS3,SPARC,SPI1,SPRY2,TEK,THBS1,TM4SF1,TRIM6	ATF2,Akt,Ap1,CTNNB1,DICER1,EGFR,ERBB2,HIF1A,JUN,MET,MYC,NFkB (complex),SMAD3,SP1,STAT3,TP53,TP73,estrogen receptor	
P1	 	KRAS	-0.412	enzyme	Activated	2.284	 	0.000	2.284	2.01E-09	AKR1B10,ALDOA,AMPH,AOX1,ATG7,AXIN2,BCL2L1,BIRC3,BMP4,BSG,CAMK1,CAV1,CCDC80,CCND3,CDH2,COL1A1,COL3A1,CXCL8,DCLK1,DDIT3,DUSP5,EIF5,ELK1,ELN,ETV5,FOS,FTH1,G6PD,GADD45A,GBA,GLUL,GPC3,GRN,HEXA,HIF1A,HLA-DRB1,HSPA5,HYOU1,ID1,IER3,IGF2BP2,ITM2A,JUN,LAMP2,LIPG,LOX,MCAM,MMD,MMP2,MYC,MYCN,MYLK,NAB1,NQO1,NR5A2,PARVA,PAWR,PCOLCE,PLAT,PRKCD,PRPH,PTGS2,RHOB,RNASE4,RNH1,SDC4,SERPINA3,SERPINE2,SLC35B1,SLC3A2,SNX16,SOX17,SOX9,SPARC,SPRY2,SQSTM1,STOM,TCEA1,TGFBR2,THBS1,THY1,TMEM98,TNFRSF10B,UBE2I,UPP1,VAPA,VCAN,ZFAND2A	ATF2,Ap1,EGFR,ERK1/2,HIF1A,JUN,Jnk,KRAS,MAX,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,TP73	
P1	 	tert-butyl-hydroquinone	 	chemical reagent	 	1.972	bias	0.435	-0.355	2.33E-09	ABCC1,AGL,ATF3,AXIN1,EMILIN1,FLRT2,FOS,FOXC1,FTH1,G6PD,GADD45A,GCLM,GSR,GSS,GSTM3,GSTM5,HMOX1,HSPA5,HSPA8,IDO1,ITGAM,JUN,JUNB,MAF,MAP1A,ME1,MYH11,NQO1,OSGIN1,SESN2,TXNRD1,ZFP36L2	AHR,Ap1,BACH1,CEBPB,ESR1,FOS,JUN,NFATC2,NFE2L2,NFKB1,NFkB (complex),Nfat (family),RELA,SMAD4,SP1,TP53,tert-butyl-hydroquinone	
P1	 	TO-901317	 	chemical reagent	Activated	3.460	 	0.160	2.481	2.40E-09	ABCA5,ABCA8,ABCG1,ACACA,ACLY,ADH1C,ADIPOR2,ADM,ALAS2,ALDH2,ALDH3A2,APOC1,APOE,ARG2,ASS1,BCL2L1,CASP4,CCL2,CDK4,CIDEA,COMT,COX17,CRAT,DHCR7,DNASE1L3,ECI1,ELOVL3,ELOVL6,ENO1,EPHX1,FBP1,FBXO3,FMO1,G6PD,GAMT,GBE1,GPAM,HP,HSD17B11,HSD17B8,IGFBP4,IL6,LDLR,LIPG,MID1IP1,MMP9,MRPS2,NFKBIA,NR1D1,NR5A2,PFKFB3,PFKL,PLTP,POR,PSMB2,PTGDS,PTGS2,RARA,SERPINA3,SIGMAR1,TGM2,THRA,THRSP,TIMP1	Ap1,CEBPB,D-glucose,ESR1,FOXO1,HIF1A,JUN,MYC,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,SREBF2,STAT3,THRB,TO-901317,USF1	
P1	 	arsenite	 	chemical toxicant	 	-0.110	 	0.191	-0.851	2.52E-09	ABCC1,ALDH3A1,ATF4,CAV1,CELF2,COL8A1,CXCL8,CYP1B1,DUSP1,EGR1,FOS,FST,GADD45A,GCLM,GPC1,HMOX1,HSPA1A/HSPA1B,HSPA9,IER3,INHBB,JUN,KLF2,MAFG,MCL1,MYC,NAPB,NBEA,NQO1,PPP1R3C,PTGES2,PTGS2,RNH1,SFRP4,SGCD,SQSTM1,THBS1,TXNRD1,VEGFD	ATF2,Ap1,EGFR,ELK1,ERK,FOS,JUN,Jnk,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,arsenite	
P1	 	TAZ	0.599	enzyme	 	-1.408	bias	0.501	 	2.60E-09	ADAMTS1,ADRB2,AHNAK2,AMPH,AOX1,AXL,C7,CAV1,CCL2,CDH2,CTGF,CYP1B1,CYR61,EDN1,ENPP2,KIT,LOX,LUM,MFAP5,MYOF,PCLO,PRSS23,S1PR1,SEMA3C,TAGLN,TFPI2,UPP1	BMP4,HDAC1,SMAD1,SMAD4,SMAD5,SMARCA4,TAZ	
P1	 	arsenic trioxide	 	chemical drug	 	0.760	 	0.108	0.055	2.71E-09	ACAT2,ATF6,BCL2L1,BNIP3L,CST3,CXCL8,CYB5R1,CYP51A1,DDIT3,DHCR24,DHCR7,FTH1,GCLM,GLRX,GLRX2,GSR,HIF1A,HMGCS1,HMOX1,HSPA5,ITGAM,KEAP1,LSS,MAF,MCL1,ME1,MMP9,MSMO1,MT1F,MT1G,MT1X,MT2A,MYC,NFKBIA,NQO1,NQO2,PFKFB1,PIR,PTGS2,S100A8,SHMT2,SQLE,TFRC,TNFRSF10B,TXNRD1	BACH1,CREB1,FOS,HIF1A,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,TP53,arsenic trioxide,hydrogen peroxide,reactive oxygen species	
P1	 	tamoxifen	 	chemical drug	 	-0.701	 	0.042	-1.003	2.82E-09	ACACA,ADM,ADORA1,AHNAK,ANG,AQP9,ASS1,BMP2,BMP4,CAT,CAV1,CCDC80,CDH2,COL11A1,CSAD,CTSD,CXCL8,CYR61,EPHX1,ERBB2,ESR1,ETV5,F13A1,FLOT1,FOS,G0S2,GAP43,GAPDH,GDF15,GJB2,H19,HMGCS1,IER3,IGFBP3,IGFBP4,IL6,INPPL1,ISG20,JUN,JUNB,LDLR,LSS,LTBP2,MIF,MYC,NNMT,ORM1,PFN1,PRSS23,PTGS2,RAMP3,RERG,SCUBE2,SELE,SEMA3B,SERPINA3,SHC1,SLC2A3,SLC7A2,SLC7A5,SMAD7,SOX9,SPP1,SQSTM1,TAGLN,TGFBR2,TXN,TYMP,UCP2	AGT,Ap1,CEBPB,ESR1,ESR2,FOS,HIF1A,IGF1,JUN,NFKB1,NFkB (complex),PPARG,RELA,SMAD3,SMAD4,SP1,STAT3,TGFB1,estrogen,tamoxifen	
P1	 	AKT1	0.317	kinase	Activated	2.608	 	0.219	1.025	2.91E-09	ACAT2,ACLY,ADIPOQ,AKR1B10,ASS1,BCL2L1,BIRC3,BMP2,C1QC,CCL2,CCND2,CCND3,CD4,CD69,CD86,CDK4,CEBPD,CIDEA,COL8A1,CST3,CXCR4,DHCR7,DLG4,EGR1,ESR1,FGF2,FOS,FOSB,GCLM,GDF15,GSTM5,HIF1A,HLA-DRB4,HMGCS1,HMOX1,IL6,IRS2,KDR,LEP,LSS,MBP,MCL1,ME1,MMP2,MMP9,MSMO1,MT2A,MYC,MYH11,NOTCH1,NQO1,PCOLCE,PHLDA1,PPP1R1B,PTGS2,RAMP3,RHOB,SLC3A2,SLC4A7,SPP1,STUB1,TGFBR3,THBS1,TIMP1,TNFSF10,VCAN	AKT1,Akt,ERK1/2,HIF1A,IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TNF,TP53	
P1	 	HMGA1	1.382	transcription regulator	 	0.179	 	0.139	-0.743	3.40E-09	ALPL,CAV1,CCND2,COL1A1,COL1A2,CSK,CTSH,CYR61,DAB2,DDIT3,DHCR7,DPYSL4,EGR1,ELK1,ESR1,FOS,GNA15,H19,ID3,IER2,IER3,IGFBP3,IGFBP4,IL6,JUNB,KIT,KLF2,LIPE,LY6E,MAPKAPK2,MIA,MMP9,MVD,MYC,NFIX,PHLDA2,PTGS2,PYCR2,RAN,RARA,RHOB,SDC4,SERPINH1,SOX17,SPARC,TAGLN,TRIM28	Akt,Ap1,CEBPA,CEBPB,EGR1,ESR1,FOS,HIF1A,HMGA1,Ins1,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PPARA,PPARG,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	paclitaxel	 	chemical drug	 	0.520	 	0.191	-0.487	3.48E-09	ANXA5,APLNR,ARHGEF2,ATF3,ATF4,BCL2L1,BHLHE41,BIRC3,BTG2,CAV1,CCL2,CCNG2,CD86,CDC20,CTGF,CXCL2,CXCL8,CYP1B1,CYP2C8,DCHS1,DDIT3,DUSP10,DUSP5,EEF1E1,EGR1,EMP1,ENPP2,ENPP4,ETV5,FAM53B,FLNA,FMO3,G0S2,GADD45B,GAMT,GDF15,GFPT2,GRINA,HBEGF,HIF1A,IDUA,IER2,IER3,IGFBP3,IL6,ITGA3,JUN,LLGL1,MCL1,MMP9,MYC,NFKBIA,NNAT,NREP,PHLDA1,PLAUR,PNKD,PRELP,PTGS2,S100A9,SLC12A2,SLC2A3,SPRY1,STC1,TBCD,TFPI2,TGFBR2,THBD,THBS1,TMEM158,TNFRSF10B,TSC22D1,TSC22D4,TULP3,TYMP	Ap1,ERK,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT3,TNF,paclitaxel	
P1	 	AHR	-0.041	ligand-dependent nuclear receptor	 	-1.917	 	0.041	-2.232	3.49E-09	ABCB6,ACTN1,ADIPOR2,ADM,ALDH1B1,ALDH2,ALDH3A1,ARG2,ATP2B1,BTG2,BZW2,CBR3,CCND3,CCNG2,CD36,CDH2,CDK4,CDKN2B,CDKN2C,CHD7,COL11A1,COL12A1,COL16A1,COL1A1,COL1A2,COL3A1,COL5A1,COL5A2,COL6A1,COL6A3,COX8A,CTSD,CYP1B1,CYP2C8,EDN1,EMILIN1,EMILIN2,ESR1,FBN2,FMO2,FMO3,FOS,FZD7,GADD45A,GHITM,GOT1,GSTM5,HEY2,HIF1A,HP,HSPA5,IL6,ITGA7,ITGAM,JUN,JUNB,KIT,KLF2,LBP,LTBP2,MATN2,MMP2,MT2A,MYC,NID2,NNMT,NQO1,PLAT,PPP1R15A,PTGS2,SAA1,SDSL,SLC16A5,SLC1A4,SNTA1,SPP1,TFF3,TGFBR2,THBS1,TIPARP,TNFRSF19,TXN,VEGFC	AHR,ATF2,Akt,Ap1,EGFR,HIF1A,IL6,JUN,NFkB (complex),PI3K (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TP53	
P1	 	P38 MAPK	 	group	 	-1.019	bias	0.408	-4.311	4.48E-09	ADAM17,ADIPOQ,ANGPT1,ANXA5,ARG2,ASS1,ATF3,ATG7,BCL2L1,BMP2,BNIP3L,CAV1,CCL2,CCL3L3,CCL8,CCND2,CCNG2,CD55,CD69,CD86,CLDN5,COL3A1,CTGF,CTSK,CXCL12,CXCL8,CXCR4,DDIT3,DUSP1,EDN1,EGR1,EGR2,ELK1,ETS1,FCER2,FGF2,FLNA,FOS,FST,GBP1,GDI1,HIF1A,HMOX1,HP,HSPA5,ID3,IER3,IL6,ITGAM,JUN,JUNB,KDELR3,KLF4,LEP,MAP4K4,MCL1,MIF,MMP2,MMP9,MYC,MYH11,NGF,NR4A3,PLA2G4A,PLAUR,PTGS2,RAB5A,RARA,RCAN1,RHOB,RUNX1,SATB2,SELE,SGK1,SOCS3,STIM1,THBS1,TIMP1,TJP2,TNFRSF10B,TNFSF10,TNIP1,TRIB1,VCAM1,VEGFC,ZFP36,ZMAT3	Ap1,ERK1/2,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF	
P1	 	TP73	-0.020	transcription regulator	 	1.073	 	0.181	-0.519	4.74E-09	ABCC1,ADAM17,AEN,ALAS2,ATF3,ATG7,BAP1,BTG2,C1R,CASP4,CCL2,CCND3,CCNG2,CDC42EP2,CDKN1C,CLIP3,CLMN,COL18A1,COL1A1,COL5A2,CTSD,CXCL2,CYR61,DBP,DDIT3,DDIT4,DHRS3,EGR1,ERCC2,FGF2,FST,G6PD,GADD45A,GPNMB,GRK5,HAGH,HSPA1A/HSPA1B,IER3,IGFBP3,IGFBP4,IL6,KIT,LDHD,LIG1,LYZ,MGMT,MIR22HG,MMP2,MMP23B,MMP28,MPZL2,MT1L,MYCN,NUPR1,P2RX4,PERP,PMP22,POLD2,PROCR,PTPN3,RELN,RNF144B,RRM2B,RUNX1,SERPINA3,SERPINE2,SLC4A3,SMUG1,SNRK,SPHK2,SPP1,THBS1,TIMP1,TIMP4,TNFRSF10B,TNFRSF12A,TPP1,TSC2,TSHZ2,TSPAN1,UVRAG,VEGFC,ZMAT3	Ap1,HDAC1,HIF1A,Hdac,JUN,Jnk,MAX,MYC,NFATC3,NFkB (complex),RELA,SNAI1,SP1,STAT3,TP53,TP63,TP73	
P1	 	KLF2	-1.133	transcription regulator	Activated	2.044	 	-0.238	3.202	5.08E-09	ADM,APLNR,ASS1,BMP4,CCL2,CCL3,CCND3,CD36,CD55,CDH2,CTGF,CXCL2,CXCL8,CXCR4,CYP1B1,EDN1,ELN,EPAS1,GADD45A,HIF1A,ID1,ID3,IL6,JUNB,KDR,LBP,LEPR,MT2A,MYC,NDRG1,NFKBIA,NQO1,PTGDS,PTGIS,PTGS2,RALA,S1PR1,SFTPD,SLCO2A1,SOX9,TFPI2,TFRC,THBD,THBS1,TIMP1,VCAM1	ARNT,CCL11,CCL5,CREB1,HIF1A,JUN,KLF2,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT1,STAT3,VHL	
P1	 	NRG1	0.027	growth factor	 	-1.052	bias	0.251	-2.527	5.16E-09	ACTN1,ANGPT1,ARHGEF2,ATF4,BIN1,CAV1,CCND2,CCND3,COL1A1,COL6A3,CTGF,CXCL8,CXCR4,CYR61,DDIT3,DNAJB2,DUSP1,EDN1,EGR1,EGR2,EGR3,ERBB2,FOS,FOSB,GLG1,GPS2,GPX3,HIF1A,HMGA1,HMOX1,HNRNPK,ID1,IER2,IER3,IMMT,IRF3,ITGAM,JUNB,LMO4,MBP,MCL1,MMP9,MST1,MYC,NOTCH1,NR4A3,PCCB,PDCD4,PFKFB1,PHKG1,PLAUR,PTGS2,RUNX1,SELE,SGSH,SLC2A3,SLC4A7,TF,VEGFC,ZFP36,ZFP36L2	ATF2,EGF,EGFR,ERK,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NRG1,P38 MAPK,RELA,SMAD3,SP1,SRC,STAT3,TP53	
P1	 	WT1	0.086	transcription regulator	 	0.093	 	0.077	-0.402	5.16E-09	AHCY,AMHR2,APRT,ARL2,ASNS,ATP5I,BCL2L1,BTG2,BTK,CAPRIN1,CBS/CBSL,CCL2,CDKN2C,CSF1R,CSPG4,CTGF,DDX3X,DESI1,EGR1,ETS1,FIBP,FOSB,GSR,HBEGF,ITGAM,ITGB1BP1,JUNB,KLF4,LSS,MCL1,MMP2,MMP9,MT1X,MYC,MYCN,NCSTN,NDRG1,NME1,NQO2,NR4A2,ODC1,PCK2,PHLDA1,PIR,PLAUR,RAB40C,RARA,SEC13,SLC20A1,SLC2A3,SLC35G2,SOS1,SOX9,SPRY1,SQLE,SQSTM1,TARS,THBS1,TM4SF1,TRAP1,TSC22D1,TYROBP,WARS,YARS	CEBPA,CEBPB,CTNNB1,HDAC1,HIF1A,IGF1,JUN,RELA,RNA polymerase II,Ras,SMAD3,SP1,STAT1,STAT3,TERT,TP53,WT1	
P1	 	F2R	-0.103	g-protein coupled receptor	Inhibited	-3.600	bias	0.483	-5.945	5.64E-09	ANGPT1,CCL2,CD55,CTGF,CXCL12,CXCL8,CYR61,DUSP1,EGR1,EGR3,FOS,HMOX1,IL6,KDR,MIF,MMP9,PTGS2,SELE,TAGLN,TEK,TFPI2,TGM2,THBS1,TJP1,TNFAIP3,VCAM1	Ap1,CREB1,F2R,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,nitric oxide	
P1	 	PSEN1	0.082	peptidase	Inhibited	-3.033	 	-0.058	-2.730	5.93E-09	ABCG1,ACO2,ACTA1,ALDOA,AMPH,APOE,ARF5,ATOX1,ATP1A2,ATP2A2,ATP5D,ATP6V1E1,AXL,BSG,C1QA,C1QB,C1QBP,C1QC,C1R,CAMK2D,CANX,CCL3L3,CDH2,CLEC16A,CLTB,COX8A,CRYM,CS,CUEDC1,CXCL2,CYTIP,DBP,DLG4,DNM1L,DUSP1,EEF1G,EGR1,EMP1,ENO1,ENPP2,FBL,FKBP1A,FOS,GADD45B,GAPDH,GNG2,GOT2,GPM6B,HINT1,HK1,HSPA5,HSPA8,HSPE1,IRF3,KIF5B,LRP1B,LRP8,MAP2K2,MAP6,MBP,MME,MMP9,MTHFD1L,MYC,NAPB,NCSTN,NME1,NOTCH1,NUPR1,PEA15,PEBP1,PKM,PRDX5,PTGS2,PTPRF,RELN,SRC,STAB1,STIP1,STXBP1,SYN1,TGFBR2,TIPARP,TNFRSF10B,TUBA1C,TUBB,TUBB2A,TUBB2B,TUFM,TXN,UCHL1,WARS	APP,Ap1,FOS,FOXO1,HIF1A,JUN,MAPK8,MTOR,NFE2L2,NFKB1,NFKB2,NFKBIA,NFkB (complex),PSEN1,RELA,SOD1,STAT1,STAT3,TP53	
P1	 	ADORA2A	-0.050	g-protein coupled receptor	 	1.410	 	0.076	0.938	7.87E-09	ALDOC,ATP1A2,ATP2A2,ATP2B1,ATP6AP1,ATP6V1B2,CCT5,CLDN5,COL3A1,COL6A1,CSF1R,CXCL2,DGAT2,DUSP1,EGR2,EIF2S2,FBL,FOS,G3BP2,GAPDH,GDI1,HMOX1,HNRNPK,IL6,KIF5B,MMP9,NAPB,NFKBIA,NR4A2,NR4A3,PEA15,PPP1R1B,PPP2R1A,PTGS2,SELE,SPARC,SPTBN1,SYT11,TIMM44,TJP1,TUBB2A,USP5,VPS4A	ADORA2A,CREB1,Creb,FOS,IL10,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pka,Pkc(s),RELA,STAT1,STAT3,norepinephrine	
P1	 	MAPT	0.208	other	 	-1.093	 	0.017	-1.143	8.38E-09	ABCG1,ACO2,ACTA1,ALDOA,AMPH,ARF5,ATOX1,ATP1A2,ATP5D,ATP6V1E1,BSG,C1QBP,C1R,CAMK2D,CANX,CAST,CLTB,CRYM,CS,DLG4,DNM1L,EEF1G,ENO1,FBL,FKBP1A,FOS,FYN,GAPDH,GNG2,GOT2,GPM6B,GSTM5,HINT1,HK1,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPE1,IL6,JUN,LRP1B,MAP1A,MAP1B,MAP6,MBP,MTHFD1L,NAPB,NDUFS3,NME1,NMNAT2,PCLO,PEA15,PEBP1,PKM,PRDX5,PRNP,SLC1A3,STIP1,STUB1,STXBP1,SYN1,TUBA1C,TUBB,TUBB2A,TUBB2B,TUFM,TXN,UCHL1	APP,ATF6,HIF1A,MAPT,MYC,NFKB1,NFKBIA,NFkB (complex),PSEN1,STAT1,STAT3,TP53	
P1	 	EP300	0.003	transcription regulator	 	0.220	bias	0.416	-2.207	8.97E-09	ACADM,ACTA1,ADIPOQ,AGT,AKAP12,AMHR2,ANGPT1,AP3M2,AQP11,ATF6,AXIN2,BCL2L1,BMF,CAMK2D,CAPG,CCL2,CCND3,CCNG2,CDKN2B,CLOCK,COL1A2,COMT,CORO2B,CRABP2,CRISPLD2,CXCL8,CXCR4,CYP11A1,DHRS3,DNAJB4,DUSP1,DUSP22,EDN1,EGR1,EPN1,ERBB2,EYA2,FRMD4A,FTH1,GM2A,GNG2,GSK3B,H6PD,HDAC11,HES6,HLA-G,HMOX1,HSD11B2,ID1,ID3,IL10RA,IL17RC,IL18RAP,IL6,JUN,KCTD1,KDR,LEP,LMNA,MAF,MAFG,MAP3K8,MGMT,MIA,MMD,MME,MYC,MYH11,NDRG1,NOTCH1,NPAS2,NTRK3,PDK4,PERP,PLA2G4A,PLAA,PLEKHF1,PPFIBP2,PRKCD,PTGS2,PTPRF,RGL1,RNF157,SDC4,SELE,SLC27A1,SMAD6,SMAD7,SOCS3,STOM,TANC2,TGFBR2,TIPARP,TNFAIP3,TNFRSF10B,TPO,WNT5B,ZFP36L2	Ap1,CREBBP,EP300,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	CD40LG	0.075	cytokine	 	-1.221	bias	0.404	-4.168	8.99E-09	ADAM17,ALCAM,ALG3,APRT,ATF3,ATF5,BCAT2,BCL2L1,BIRC3,BTG1,BTG3,CAST,CCL18,CCL2,CCL3,CCND3,CCNG2,CCR1,CD1C,CD69,CD86,CELF2,CLIP1,CSF2RA,CSTF2,CTGF,CXCL2,CXCL8,CXCR4,CYP1B1,CYTIP,DUSP1,DUSP5,EGR1,FBL,FOS,FOSB,FSCN1,G0S2,GADD45A,GPR183,HDDC2,HIF1A,HLA-DRB4,HRSP12,HSPA1A/HSPA1B,ID3,IDO1,IFIT2,IL10RA,IL6,ITGAM,ITPA,JUN,JUNB,KIF2A,LAMP3,LIG3,MAP2K3,MCL1,MIF,MT1E,MT1G,MT1L,MT2A,MYC,NET1,NFKBIA,NINJ1,PAWR,PLAUR,PSMB10,PSME2,PSMG1,PTGS2,PVR,RAD21,RGS1,SELE,SMG7,SPHK2,SWAP70,TFRC,TGM2,TM7SF2,TNFAIP3,TNFSF10,TNIP1,TUBB,TYMP,UVRAG,VCAM1	CD40LG,HIF1A,IL1B,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,STAT6,TNF	
P1	 	PRL	-0.022	cytokine	 	1.223	bias	0.329	-1.479	9.15E-09	AKR1C3,AKR1C4,ANXA3,ANXA5,CAMK1,CAPN2,CAV1,CCL2,CCND3,CD69,CDK4,CEBPD,CLDN5,COL1A1,COL1A2,COL3A1,COL5A1,CST3,CTSA,CTSB,CTSD,CTSH,CYP11A1,EGR1,ENO1,ERBB2,ESR1,FOS,GPNMB,GSTM1,HSD11B2,ID1,ID3,IGFBP3,IL6,ITGA1,JUN,LAMP3,LHCGR,LY6E,LYVE1,MAFG,MARS,MGP,MLKL,MME,MYC,N4BP1,NUPR1,ODC1,PARM1,PARP10,PC,PCOLCE,PDIA5,PDK4,PLAT,PSME2,PTGFR,RASD1,RNASE4,SERPINA3,SFRP2,SOCS2,SOCS3,SP110,SPARC,SPP1,TECR,TIMP1,XAF1	CEBPB,ERK1/2,ESR1,ESR2,FOS,HIF1A,IGF1,JUN,MAPK1,NFKB2,NFKBIA,NFkB (complex),PGR,PRL,RELA,SMAD3,SP1,STAT1,STAT3,beta-estradiol,progesterone	
P1	 	PRKCA	-0.102	kinase	 	-1.601	bias	0.277	-3.060	9.41E-09	ACTA1,BCL2L1,BNIP3L,CAV1,CCL2,CD55,COL1A1,CSTA,CTGF,CTSB,CXCL2,EGR1,ERBB2,ETS1,FOS,GBA,GDF15,HS2ST1,HSPA1A/HSPA1B,ID1,ID3,IGFBP3,JUN,MMP9,MYC,NFKBIA,NQO1,PEG10,PHLDA2,PRKCD,PTGS2,PVR,RUNX1,S100A8,S100A9,SDCBP,VCAM1	Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PRKCA,RELA,SMAD3,SP1,SRC,STAT3	
P1	 	10E,12Z-octadecadienoic acid	 	chemical - endogenous mammalian	 	0.202	 	0.113	-0.304	9.57E-09	ADIPOQ,ATF3,ATF4,CA3,CAV1,CBR3,CCL2,CD36,CREB5,CXCL8,DDIT3,EBF1,GDF15,IL6,LDLR,LPIN1,ME1,NR4A2,NR4A3,PLIN1,PLIN2,PPP1R15A,PTGS2,SORBS1,SOX7,TRIB3,UCP2	10E,12Z-octadecadienoic acid,ATF6,ERK1/2,FOXO1,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SMAD3,SREBF1,STAT3,fatty acid,oleic acid,palmitic acid	
P1	 	F10	0.229	peptidase	 	-1.178	 	0.185	-1.856	1.08E-08	CCL2,CTGF,CXCL8,CYR61,DUSP10,DUSP14,EGR1,IL6,MIF,MMP2,NFKBIA,SELE,TNFAIP3,VCAM1	Ap1,ETS1,F10,F2,F2R,JUN,NFKB1,NFKBIA,NFkB (complex),PROC,RELA,SP1,STAT3,VEGFA	
P1	 	MGEA5	-0.308	enzyme	 	1.941	 	-0.045	2.354	1.09E-08	ACADM,ACO2,ACSL4,ADGRG2,ADRM1,AHNAK2,ALDOC,APOE,ASS1,ATP5I,BCL2L1,C1QA,C1QB,CALCRL,CASQ2,CAV1,CCL2,CCL3L3,CCNG2,CCR1,CD14,CD24,CD302,CD36,CD55,CD68,CD86,CDKN2B,CDKN2C,CH25H,CIAPIN1,CMTM8,CNN1,CRABP1,CREB5,CSF1R,CXCL16,CXCL8,DAB2,DCLK1,DHCR7,EFNB2,EGR2,ELK1,EPHB3,EPHB6,FBP1,FLNA,FSCN1,G6PD,GAA,GADD45A,GLUL,GPR34,GTF2IRD1,GTF3A,HIPK2,HMGCS1,HSDL1,ICK,IGFBP3,IGFBP4,JUN,LSS,MCAM,MSMO1,MTX1,MYO10,NDUFA13,NDUFA9,NDUFB9,PECR,PLCE1,RBP4,RHOB,SDPR,SERPINE2,SLC27A1,SOCS2,SOCS3,SORBS1,SOX9,TGFBR2,TGFBR3,THBS1,THRA,TIMP1,TNFRSF12A,TP53BP1	CEBPB,CHUK,EGR1,ESR1,ESR2,FOXO1,Growth hormone,HIF1A,Insulin,MGEA5,NFKB1,NFKB2,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,STAT3	
P1	 	IGF1	-0.248	growth factor	 	1.859	bias	0.293	-0.766	1.10E-08	ACACA,ACTA1,ADIPOQ,ADM,BCL2L1,BIRC3,BMP2,BMP4,BSG,C1QA,CCL3L3,CCND2,CCND3,CCNG2,CDK4,CEBPD,COL1A1,COL3A1,CTGF,CTSD,CXCL8,CYBA,CYP11A1,CYR61,DCLK1,DDIT3,DDIT4,EDN1,EFNB2,EGR1,EGR2,ELN,EPAS1,ESR1,ETV6,FOS,FOSB,GAP43,GAPDH,HDC,HIF1A,HMGA1,HMOX1,HSD11B2,HSPA5,IER3,IGFBP3,IGFBP4,IGFBP6,IL6,IRS2,JUN,JUNB,KIF1A,LARP6,LEP,LEPR,LHCGR,MAFG,MBP,MCL1,MIF,MMP2,MYC,MYCN,MYH11,NCF2,NFKBIA,NOX4,NUPR1,ODC1,OSBPL7,PCOLCE,PHLDA1,PLA2G2A,PLAUR,PPP1R1B,PRNP,PTGS2,SELE,SLC20A1,SOCS3,SPP1,SQLE,SRD5A1,SRSF3,SYN1,TF,THBS1,THRSP,THY1,TJP1,TNFRSF12A,VCAM1,VEGFC	Akt,ERK1/2,FGF2,HIF1A,IGF1,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT3,TNF,TP53	
P1	 	indomethacin	 	chemical drug	Activated	2.791	 	0.148	1.662	1.27E-08	ADAMTS1,ANGPT1,ASNS,ATP6V0B,BCL2L1,BIRC3,BSG,BTG2,CAPN2,CAPN6,CBX4,CCL2,CCL3L3,CD14,CD55,COX8A,CTSD,CXCR4,CYP2C8,EFEMP2,EMP3,FGF2,FOS,GBA,GDF15,GPNMB,GSTM3,HIF1A,HMOX1,IDO1,IER3,IL6,ITGAM,KRT8,LDLR,LIMA1,LXN,MMP2,MYC,PLA2G4A,PLAUR,PLIN2,POMC,PSMB10,PSMB5,PTGER4,PTGS2,RCN1,RPS21,S100A8,SLC7A5,SPP1,STRN4,TEK,TFPI2,TIMP1,TJP1,TNFRSF10B,TNFRSF12A,TNFRSF21,TUBB,UCP2,UPP1,UQCR10,VCAN	Ap1,ERK1/2,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,SMAD3,SP1,STAT1,STAT3,TP53,indomethacin,prostaglandin E2	
P1	 	palmitic acid	 	chemical - endogenous mammalian	 	-0.370	 	0.215	-1.769	1.31E-08	ACACA,ACADM,ACLY,ADIPOQ,ADIPOR2,ALDOA,ATF3,ATF4,ATF6,BIRC3,CCL2,CCL3L3,CD36,CIDEA,CS,CTGF,CTSB,CXCL2,CXCL8,CYBA,DDIT3,DGAT2,ERN1,FOS,GAPDH,GDF15,HMOX1,HSPA5,IL6,IRS2,LEP,MTOR,NCF2,NFKBIA,NR4A2,NR4A3,PLIN2,PROCR,PTGS2,SLC25A1,SOCS3,SQSTM1,THBD,TNFRSF10B,TNFSF10,TRIB3,UCHL1,UCP2,VCAM1	ADIPOQ,CREB1,D-glucose,FOS,FOXO1,Growth hormone,HIF1A,Insulin,MYC,NFKB1,NFkB (complex),PPARA,PPARD,PPARG,Pkc(s),RELA,SREBF1,STAT3,fatty acid,palmitic acid	
P1	 	CLDN7	0.388	other	 	0.235	 	0.008	0.183	1.35E-08	AGT,ALDH3A1,ANXA3,APOE,ATP5G1,CA12,CD68,CKAP4,CTGF,CXCL8,DNAJB6,FADS3,FZD2,GRINA,HIST2H2AA3/HIST2H2AA4,HIST2H2AC,LIMA1,LYSMD2,MMP2,MMP9,MRPL40,MRPS15,MT1A,MT1X,MT2A,NCOA7,NNMT,NTPCR,PLGRKT,PRNP,PRSS23,RPL34,RPP40,RRAS2,SLC25A22,SLC35B1,SLCO2A1,SYTL2,TINAGL1,TJP1,XXYLT1	 	
P1	 	BDNF	0.123	growth factor	 	0.307	 	0.201	-1.157	1.43E-08	ACOT7,ADRB2,ANXA5,AP3D1,ATAT1,BCL2L1,BMP2,CCND2,CSPG4,CXCR4,CYGB,CYR61,DUSP1,EGR1,EGR2,ELOVL6,EPB41L2,FAM49A,FLNA,FOS,FOSB,FSCN1,GAP43,GLUL,GNAI1,GPC4,GPS1,GRB14,HADHA,HSPA2,HSPA5,IFRD1,IL6,INHBB,JUN,KIF1A,LEP,MACROD1,MAP1B,MAPK8IP3,MBP,MVD,MYCN,MYO5A,NAPB,NCDN,NR4A3,PALMD,PFKFB3,PLTP,PLXNB2,POMC,PPP1R1B,RELN,RNH1,S100A9,SERPINH1,SFRP1,SFRP2,SORL1,SPARC,SPP1,SPRY2,STRN4,STXBP1,SYN1,SYN2,TAGLN,TBC1D8,TFRC,THRA,TIPARP,TMED2,TP53BP1,TPP1,ZFPM1	BDNF,CEBPB,CREB1,CREBBP,CREM,Ca2+,Creb,ELK1,FOS,HDAC2,Hdac,JUN,LEP,NFkB (complex),PPARG,Pkc(s),RELA,RNA polymerase II,SP1,SRF,STAT3,TP53	
P1	 	dinoprost	 	chemical - endogenous mammalian	 	-0.194	 	0.182	-1.042	1.49E-08	ADM,AKR1C4,ATP2A2,CCND2,CD36,CYP11A1,EDN1,ESR1,FGF2,FOS,GSTM1,HSD11B2,HSPA1A/HSPA1B,HSPA4,ID1,ID3,IL6,JUN,LHCGR,MMP9,MYC,NR4A2,PLA2G4A,POR,PTGFR,PTGS2,PTX3,SPP1,THBS1,THRSP	Akt,CEBPB,CREB1,Ca2+,ERK1/2,ESR2,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PGR,RELA,SMAD3,SP1,STAT3,TNF,TP53,dinoprost,progesterone	
P1	 	IL15	-0.061	cytokine	 	-0.712	bias	0.331	-2.974	1.53E-08	ACTG2,ATF4,BAMBI,BCL2L1,BTG1,CCL18,CCL2,CCL3,CCND2,CCND3,CCR1,CD55,CD59,CD69,CD86,CDK4,CDKN2B,CMKLR1,CTGF,CXCL12,CXCL2,CXCL8,CXCR4,DDT,DHRS4,DUSP14,DUSP5,EDN1,EGR2,ETS1,FCGR3A/FCGR3B,FKBP1A,FMO3,FYN,G6PD,GAPDH,GARS,HAVCR2,HCST,HIST2H2AA3/HIST2H2AA4,HSPA8,HSPE1,ID4,IL18RAP,IL6,JUN,JUNB,KIT,LEP,LSP1,LYN,MAF,MCL1,MIF,MST1,MT1G,MYC,MYH1,NFKBIA,NME1,OGN,PA2G4,PCBP2,PDCD4,PFN1,PSMB10,RBBP8,RGS16,SMAD7,SOCS2,SORL1,SOS1,SRGN,TCEA1,TFRC,TGFBR2,TIMP1,TJP1,TJP2,TNFRSF10B,TNFSF10,TRIM5,TXNRD1,TYROBP,UPP1,VCAM1,YARS,ZFP36	IFNG,IL15,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,STAT1,STAT3,TNF	
P1	 	TNFSF10	-0.992	cytokine	 	0.044	 	0.091	-0.457	1.68E-08	ANGPT1,BCL2L1,BIRC3,CD14,CD69,CTSB,CXCL8,CXCR4,DIABLO,DPYD,FOS,FTH1,HLA-F,IFI27,IL6,ITGAM,JUN,MCL1,MMP2,MMP9,NFKBIA,PRKCE,PSME2,PTGS2,RCAN1,SELE,SERPINH1,TAF6,TFRC,TIMP1,TNFAIP3,TNFRSF10B,TNFSF10,TNK2	IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TNFSF10,TP53,prostaglandin E2	
P1	 	ERK1/2	 	group	 	-0.900	bias	0.308	-3.296	1.70E-08	ADIPOQ,AKR1B10,AKR1C3,ATF6,BCL2L1,BIRC3,BMP2,CAT,CAV1,CCL2,CCL3,CCL3L3,CCL8,CCND2,CD86,CDK4,COL1A1,COL3A1,CTGF,CTSB,CXCL8,CXCR4,DUSP1,EDN1,EFNB2,EGR1,ELK1,ENO1,ESR1,ETS1,FGF2,FOS,FOSB,GRK5,H19,HBEGF,HIF1A,HMGA1,HSPA5,ID1,ID3,IGFBP3,IL6,IRS2,ITGA3,JUN,JUNB,LDLR,LEPR,MAP2K2,MMP2,MMP9,MYC,MYCN,NOX4,NR4A3,PLAUR,PSMB10,PSMB6,PTGER4,PTGS2,PTPRE,RAB4B,SGK1,SOCS3,SOX9,SPP1,TIMP1,TNFRSF10B,TYMP,VCAM1,VCAN	ATF2,Ap1,CEBPB,EGFR,ERK1/2,HIF1A,IGF1,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TNF	
P1	 	TNFSF11	-0.024	cytokine	 	0.490	bias	0.396	-2.605	1.71E-08	ACP5,ADRA1A,AEBP2,AQP9,BCL2L1,BMP4,BSG,CAPN2,CAV1,CCL2,CCL3L3,CCND3,CCR1,CD14,CLOCK,CSF1R,CTSK,CXCL8,DAB2,DOK2,DUSP1,EGR2,ESR1,ETS1,FOS,GADD45B,GLRX,GRN,HIPK2,HMOX1,IER3,IL11RA,IL6,ITGAM,JUN,JUNB,KEAP1,MMP9,MYC,NFKBIA,NFKBIZ,PA2G4,PAG1,PCDH7,PHLDA3,PLAUR,POR,PTGER4,PTGS2,PTPN23,PTPRE,RCAN1,RCL1,RGL1,RGS16,RHOB,SDC4,SH3PXD2A,SIGMAR1,SLC20A1,SOCS3,SPP1,SRC,SRXN1,TNIP1,TSPAN13,VCAM1	Ap1,CHUK,ERK,FOS,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNFSF11	
P1	 	raloxifene	 	chemical drug	 	-1.305	 	0.000	-1.305	1.78E-08	ALDH4A1,ANXA3,BMP2,BMP4,CBX6,CD24,CTSH,CXCL12,CYP1B1,DDIT4,DUSP1,EGR3,ENPP2,ERBB2,ESR1,HIST2H2AA3/HIST2H2AA4,HMOX1,HSPA1A/HSPA1B,IER3,IGFBP4,IL6,INHBB,JUN,KIAA0922,KLF6,LDLR,LITAF,LUM,MATN2,MFAP5,MIF,MMD,MMP2,NDRG1,PPP1R3C,PRSS23,PTGS2,PTTG1,RAP1GAP,SIAH2,SLC22A5,SLIT2,SMAD7,SMPD1,SPP1,STC1,TFRC,TGFBR2,THBD,TIMP1,TM4SF1	Akt,CEBPB,CREB1,ESR1,ESR2,FOS,FSH,HIF1A,IGF1,IL6,JUN,NFKB1,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,raloxifene	
P1	 	cerivastatin	 	chemical drug	 	-0.048	 	-0.046	0.151	2.13E-08	AGTRAP,ASS1,BMP2,CCL2,CCL3,CD36,COL1A1,CTGF,CXCL8,CYP1B1,ETV6,FGF2,HMGCS1,HMOX1,IL6,JUN,KLF2,MMP9,MYC,NET1,NR2F6,PLAT,PLAUR,PTGDS,PTGS2,S100A8,S100A9,TGFBR3,THBD,VCAM1	Ap1,F2,HIF1A,IL1B,JUN,Jnk,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,cerivastatin	
P1	 	benzo(a)pyrene	 	chemical toxicant	 	0.852	 	0.225	-0.499	2.33E-08	ABCB6,ABHD4,AJUBA,ALAS2,ALDH3A1,ARHGDIA,ARHGEF6,BTG3,CEBPG,CELF2,COL8A1,COMT,CYB5A,CYP1B1,CYR61,DOK5,EPHX1,FOS,FST,FYN,G6PD,GCLM,GNA11,GNAI1,GPC1,GSTM1,HMOX1,HP,HRAS,HSPA1A/HSPA1B,IER3,IGFBP6,ING1,INHBB,JUN,KLF2,MAF,MAFG,MAP2K3,ME1,NAPB,NBEA,NQO1,PDCD6,PGD,PPP1R3C,PTGS2,RAE1,RAP1GAP,RGS5,SFRP4,SGCD,SLC1A4,SQSTM1,TAF6,TF,THBS1,TXNRD1,UBL7,VEGFD,ZMAT3	AHR,Ap1,CEBPB,ERK,ESR1,JUN,MYC,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,SMAD3,SMAD4,SP1,STAT3,TP53,TP73,benzo(a)pyrene	
P1	 	deferoxamine	 	chemical drug	Inhibited	-2.169	 	0.218	-3.637	2.54E-08	ADM,ALDOA,ANGPTL4,CCL3L3,CCND2,CCND3,CD59,CXCL8,DDIT3,DUSP1,DUSP10,DUSP5,EGR1,ELN,ENO1,EPAS1,FOS,GADD45A,GADD45B,GDF15,HIF1A,HMOX1,HSPA13,HSPA1A/HSPA1B,IGFBP3,IGFBP4,IL6,ISG20,LEP,MMP2,MYC,MYCN,NDRG1,NR4A2,PFKFB1,PFKFB3,PKM,PLA2G4A,PLAT,PLAUR,SELE,SERPINE2,SLC2A3,SMAD7,SPP1,TFRC,TNFRSF10B,TSC22D1,VCAM1	ARNT,Ap1,ERK1/2,HIF1A,JUN,Jnk,MAX,MYC,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SMAD3,SP1,STAT3,TP53,VHL,deferoxamine	
P1	 	ERBB4	0.004	kinase	 	0.176	 	0.024	0.045	2.70E-08	ACTA1,BTG2,CASP4,CCL2,COL3A1,COL5A2,CXCL12,DDIT3,DUSP1,EFNB2,EGR1,GADD45A,GAP43,GPAA1,GPC1,GZMH,HBEGF,HIF1A,HMOX1,IGFBP4,JUN,MAP2K3,MYC,PTGIS,PTGS2,SERPINA3,SERPINE2,SFRP1,SLK,SOCS3,THBS1,VEGFD	ATF2,Ap1,EGFR,ERBB2,ERBB3,ERBB4,ESR2,JUN,MYC,NFkB (complex),PGR,PI3K (complex),RELA,SMAD3,SP1,STAT3,TP53,estrogen receptor,prostaglandin E2	
P1	 	GDF2	-0.036	growth factor	 	-0.737	bias	0.453	-3.189	2.70E-08	ANXA3,CAV1,COL1A1,CRABP1,CXCL12,CXCL8,CXCR4,EDN1,EFNB2,ENPP2,ENTPD6,FOS,GADD45B,GJA4,HIF1A,ID1,ID3,LYVE1,MMP9,MYC,NGF,NINJ1,NRP1,SELE,SEMA3B,SEMA3C,SERPINE2,SLC3A2,SMAD6,SMAD7,SOCS2,SPP1	ACVRL1,CTNNB1,ERK1/2,GATA4,GDF2,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,RELA,RUNX2,SMAD1,SMAD3,SMAD5,SP1,STAT3,Smad	
P1	 	Insulin	 	group	 	0.771	 	0.161	-0.545	2.94E-08	ACACA,ACADM,ACAT1,ACLY,ACTA1,ADIPOQ,ADIPOR2,ADRBK1,AEBP1,AGT,ALDOA,ANGPTL4,APOE,AQP9,ARG2,BCL2L1,CA3,CCL2,CCND3,CCNG2,CD36,CIDEA,COL1A1,CYP11A1,DDIT4,DEFB1,DUSP1,EDN1,EGR1,EPAS1,FOS,FOSB,G6PD,GRB14,GSK3B,HIF1A,HMOX1,HNRNPK,HSPA5,IGFBP3,IGFBP4,IL6,IRS2,JUN,LEP,LEPR,LIPE,LPIN1,MAOA,ME1,MMP2,MMP9,MTCH2,MTOR,MYC,NDUFB9,NFKBIA,NR4A2,NR4A3,NUCB2,ODC1,PCCB,PDK4,PKM,PLIN1,POMC,PPP1R15A,PRKCD,RBP4,RDH5,SLC2A3,SLC2A5,SLC2A8,SLC7A1,SORBS1,SQLE,SRD5A1,SRSF3,THRSP,TJP1,TPO,UCP2	ATF4,CEBPB,D-glucose,E2F1,EGR1,FOXO1,HIF1A,IGF1,Insulin,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SIRT1,SMAD3,SP1,STAT3,TNF	
P1	 	bexarotene	 	chemical drug	 	-0.670	 	0.009	-0.726	2.99E-08	ADRB2,AKR1C3,APOE,ASNS,AXL,CCL2,CEBPG,CTSH,CYR61,DDIT4,DHRS3,DUSP1,DUSP5,EGR3,GARS,GPM6B,ID1,IER2,IGFBP6,ITM2A,MAF,MAP3K8,MMP9,MTHFD2,ODC1,PLAT,PLAUR,PTGS2,S100A9,SIAH2,SLC27A1,SLC7A1,SLC7A5,SPARC,TGM2,TM4SF1,VCAM1	CEBPA,CEBPB,FOXO1,IL6,LPL,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT1,STAT3,TNF,TP53,bexarotene	
P1	 	IL13	-0.002	cytokine	Activated	2.258	 	0.210	0.394	3.02E-08	ACADVL,ADORA1,ALDH1A2,ARG2,ATF3,AVPI1,BCL2L1,BZW2,CAPN2,CCL18,CCL2,CCL3,CCL3L3,CD14,CD163,CD163L1,CD1C,CD209,CD36,CD4,CD86,COL18A1,COL1A1,COL1A2,COL3A1,COL6A2,CTGF,CTSB,CTSH,CTSK,CXCL2,CXCL8,CXCR4,DHCR24,DNASE2,DUSP10,EGR1,ENPP2,EPAS1,F13A1,FAM162A,FCER2,FKBP1A,FLOT1,G0S2,G6PD,GPNMB,GPX3,HDC,HK1,HMOX1,HOMER2,IARS,IDO1,IL11RA,IL6,KLF6,MAF,MAOA,MATK,MCL1,MCUR1,MMP2,MMP9,MN1,MS4A4A,MSMO1,MT1X,MTSS1,NCLN,PHLDA1,PLA2G4A,PTGS2,QSOX1,S100A8,SLC7A2,SOCS3,SPINT2,SPP1,ST3GAL6,STXBP1,SWAP70,TFF3,TGM2,THBS1,TIMP1,TIMP4,TNS1,TPSAB1/TPSB2,VCAM1	IL10,IL13,IL1B,IL4,IL6,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,STAT6,TNF	
P1	 	25-hydroxycholesterol	 	chemical reagent	 	-1.036	 	0.067	-1.367	3.09E-08	ABCG1,ACAT2,ACLY,ASNS,ATF3,ATF4,CHAC1,CXCL8,DDIT3,FAM189B,FCER1A,FOS,FOSB,GPX3,HMGCS1,HMOX1,HSPA5,IL6,JUN,JUNB,LDLR,NFKBIA,NR4A2,NR4A3,PTGS2,TRIB3	25-hydroxycholesterol,ATF2,Ap1,ESR1,HIF1A,JUN,NFATC2,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PPARA,PPARG,PRKCE,RELA,SREBF1,SREBF2,STAT1,STAT3,arachidonic acid,cholesterol	
P1	 	KIAA1524	0.065	other	 	-0.966	 	-0.195	0.003	3.09E-08	ACTG2,CDKN2B,CFB,COL15A1,COL8A1,CORO6,GADD45A,GPNMB,GPR183,IER3,LUM,LXN,MFAP5,MYC,NCL,PDK4,PDLIM7,PLAUR,PRG4,PTPRB,RHOD,S100A16,SCIN,SERPINE2,SLC12A8,SLC22A18	 	
P1	 	IGF2	0.357	growth factor	 	0.130	 	0.179	-0.526	3.15E-08	ALAD,ARHGDIA,ARHGEF2,BMP2,CCNG2,CD36,CORO2B,CTGF,CXCR4,CYP1B1,DDIT3,DHCR7,DUSP1,EGR1,EGR2,FEM1A,GADD45A,GRN,H19,HBEGF,HIF1A,IDH1,IER2,IER3,IGF2R,IGFBP3,IGFBP4,IGFBP6,IL6,JUNB,KLF9,LEP,MCM2,MYC,NDRG1,NFKBIA,NGF,OGN,PDCD4,PHLDA1,PTGS2,RGS16,RHOB,SLC20A1,SOCS3,SPP1,THRA,TOMM40,ZNRD1	ATF2,Ap1,CEBPB,CREB1,EGFR,FOS,HIF1A,IGF1,IGF2,IKBKB,INSR,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PDX1,RELA,SMAD3,SP1,STAT3,STAT5a/b	
P1	 	SMARCA4	0.334	transcription regulator	 	-0.198	bias	0.458	-4.234	3.33E-08	ACTA1,ADGRG1,ADIPOQ,AGT,AHNAK,ALDH1A3,ALDH2,ANO1,AP1S2,AP3M2,ARL16,ARRDC4,ASCC1,ASNS,ATG9A,BAMBI,BIN1,BIRC7,BMP4,BNIP3L,C19orf12,C1orf54,CCL2,CCR1,CD163L1,CDKN2B,COL7A1,CORO6,CSF2RA,CTGF,CTSB,CTSH,CXCR4,CYP4B1,DHRS9,EBF1,ECM2,EDNRA,EGR1,ELOVL6,EMP3,ESPNL,ETS2,FADS3,FBP1,FMO2,FOS,GADD45A,GAPDH,GBP1,GCAT,GPR183,GULP1,GYS1,HCST,HEY1,HLA-F,HNMT,ID3,IER3,IFI27,IGFBP4,IL20RB,IL6,ITGA3,ITGA7,JUN,KCNJ2,KCNS3,KDR,KIT,LMNA,LOX,LUM,MAP1B,MGP,MMP2,MN1,MT1L,MYC,MYH11,MYL5,MYLK,NFKBIZ,NRP1,OCIAD2,PARVA,PERP,PHLDA2,PKIA,PLAT,PLAUR,PLIN2,PTX3,RAB38,RGS1,SEMA3B,SERPINE2,SERPINH1,SERTAD1,SLC11A1,SLC35G2,SLF1,SMAD6,SNAPC2,SOCS2,SOX17,SPOCD1,SPP1,SPRY2,SRPX,ST6GALNAC4,STAMBPL1,STXBP6,TAGLN,TBX15,THY1,TNFAIP8,TNFRSF14,TNFSF10,TPM1,TSPAN13,TUBB,TXNRD1,WDR45	Ap1,CEBPA,CEBPB,EGR1,ESR1,HDAC1,Histone h3,MYC,NFkB (complex),RELA,RNA polymerase II,SMAD3,SMARCA4,SP1,SP3,STAT1,STAT3,TP53,TP73	
P1	 	STAT4	-0.184	transcription regulator	 	0.577	bias	0.501	 	3.40E-08	ACAP1,ACP6,AHNAK,ALDOC,AP2A2,ARMCX1,ASPH,ATF4,BCL2L1,BSG,C10orf54,CAPN5,CCL2,CXCL2,DAPK2,DDAH2,DNAJB6,ETV5,FCER1G,FSCN1,FZD7,GBE1,GLG1,H3F3A/H3F3B,HES6,HIST2H2AA3/HIST2H2AA4,IER3,IFIT2,IL10RA,IL18RAP,IL6,ISG20,ITGA7,KLF9,LPIN1,MAP3K8,MAPK8IP3,MATK,MYC,NDRG1,P4HA2,PGP,PKP2,RAMP2,RCN3,RGCC,RGS16,RRAGD,SELE,SERTAD1,SH3BP4,SH3GLB1,SLC2A3,SMPDL3A,SOCS3,STC2,SUN1,TIMP1,TUBB2B,ZNF524	CEBPA,CEBPB,IFNG,IL17A,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,STAT4,STAT6,TP53	
P1	 	HOXA10	-0.062	transcription regulator	 	0.342	 	-0.167	1.502	3.41E-08	ACTA1,ADIPOQ,ADM,AIMP2,ALAS2,ALDH1A1,ALDH1A2,ALPL,APOE,ARL2,ATP1A2,CA3,CD1C,CDKN2B,CLDN5,COL15A1,COL3A1,CSF3R,CSTA,CTSG,DBP,DHRS9,EGR2,EMX2,ENPP2,FAF1,FCER1G,FST,FZD5,HMBS,ID1,IGFBP3,IRX3,KCNAB1,KLF9,LAMA2,LEPR,LYZ,MAP1B,ME1,MYCN,MYLK,NCF2,PBX3,PRKCD,PTGER4,RNASE4,SLC27A1,SOS1,TGFBR3,THBD,THRSP	 	
P1	 	doxorubicin	 	chemical drug	 	-0.324	 	0.180	-1.918	3.45E-08	ABCC1,ABCC3,ADAMTS1,ADM,ASNS,ATF3,ATG7,ATP2A2,BCL2L1,BIRC3,BMP4,BNIP3L,BTG1,BTG2,CAMK2D,CAPN6,CAT,CD14,CHCHD6,CHEK2,COL3A1,CTGF,CTSB,CTSD,CXCL8,CYR61,DDIT3,DPAGT1,DUSP1,DUSP5,EDN1,EFEMP2,EGR1,EMP3,ERBB2,ESR1,FOS,FTH1,GADD45A,GDF15,GLB1,GPNMB,GSR,GSS,GSTM3,HBEGF,HIF1A,HIPK2,HMOX1,ID1,IER3,IGFBP6,JUN,KMT5A,LIMA1,LOC102724788/PRODH,LXN,MCL1,MMP2,MYC,NDRG1,NFKBIA,NOL3,NOX4,NQO1,OSGIN1,PANK1,PERP,PIDD1,PMEPA1,PSMB10,PTGDS,PTGS2,PTTG1,RCN1,RELN,RGS16,RRM2B,RUNX1,SLC22A5,SMAD7,SOX9,SPP1,TIMP1,TNFRSF10B,TNFRSF12A,TNFSF10,TUBB,TXN,UPP1	Ap1,HIF1A,IL1B,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,TP73,doxorubicin	
P1	 	Tgf beta	 	group	 	-0.116	 	0.218	-1.727	3.90E-08	ACKR2,ADH1C,ANGPTL4,AXIN1,BAMBI,BCL2L1,CCL2,CCL3,CCL3L3,CCND2,CD209,CDH2,CDKN2B,COL1A1,COL1A2,COL7A1,CSF1R,CTGF,CTSK,CXCL2,CXCL8,CXCR4,CYR61,DAB2,EDN1,EGR2,FGF2,FOS,FSCN1,FST,GADD45B,GUSB,HEY1,HMOX1,IDO1,IGFBP3,IL6,JUN,JUNB,LOX,MAF,MIF,MMP2,MMP9,MN1,MYC,MYCN,NEDD9,NOX4,NR4A2,PLAT,PMEPA1,PTGS2,RUNX1,SELE,SMAD7,SOCS3,SPARC,SPP1,TAGLN,TIMP1,VCAM1	IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TGFB1,TNF,Tgf beta	
P1	 	IgG	 	complex	 	0.293	 	-0.238	1.899	3.90E-08	ADGRG1,ADM,APOE,BCL2L1,CCL2,CCL3,CCND2,CD86,CDKN2B,CEBPD,CLDN5,COL3A1,CRABP2,CSNK2B,CXCL8,CYP27A1,DDIT3,DHCR7,DUSP1,DUSP14,EDN1,ELK1,EMP1,FOSB,FST,HDGF,HSPA5,IER2,IL6,LDLR,MMP9,MYC,NGF,PEA15,PHLDA2,PLAUR,PLS3,PPP1R15A,PTGS2,RND2,S1PR1,SLC2A3,STK24,TNFAIP3,TOB1,TRIM29,TUBB2A,VCAM1,ZFP36	IL1B,IgG,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TLR4,TNF	
P1	 	EPAS1	-0.737	transcription regulator	Inhibited	-2.087	bias	0.387	-4.197	4.25E-08	ACACA,ACP5,ADM,AKAP12,ALDOC,ANGPTL4,ARG2,AXL,BIRC3,C1QA,CA12,CAT,CAV1,CTGF,CXCL2,CXCR4,CYP51A1,DDIT3,DECR2,EDN1,ENO1,FHL1,FOS,GADD45B,GBE1,HIF1A,HIST1H1C,HMGCS1,HSPA4,HSPA5,IGFBP3,IL6,INHBB,IRS2,KDR,LDLR,LOX,MIF,MYOM2,NDRG1,NOTCH1,PFKFB3,PLIN2,RET,SCAP,SFTPD,SLC2A3,SLC7A5,SOX9,STC2,TAF9B,TEK,TNFAIP3,UNG	ATF2,CTNNB1,EGFR,EPAS1,HDAC1,HIF1A,JUN,MAX,MYC,NFkB (complex),NOTCH1,PPARA,PPARD,PPARG,RNA polymerase II,SMAD3,SP1,SREBF1,STAT3,TP53,Vegf,fatty acid	
P1	 	APOE	1.573	transporter	 	-1.235	bias	-0.282	0.357	4.75E-08	ACAT1,ADIPOQ,APOB,APOE,BMP4,C5AR1,CAT,CAV1,CCL3L3,CCND2,CD36,CD68,CD86,COL18A1,COL1A1,CTGF,CTSB,CTSD,CTSK,CYR61,EDN1,EGR1,EMILIN1,FKBP4,FOS,GPX3,HMOX1,IGFBP6,IL10RA,IL6,ITGA3,ITGAM,JUN,KCTD10,LDLR,LEP,LIPG,LRP8,LTBP2,LTBR,MGP,MMP2,MMP9,NCF2,NOX4,PHLDA1,PMEPA1,PTGS2,PTX3,S100A8,S100A9,SDC4,SELE,SERPINA3,SOCS3,SPP1,THY1,TIMP1,TNFRSF14,VCAM1,WBP2	APOE,CD44,ELK1,FOXO1,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF	
P1	 	TGM2	-1.559	enzyme	 	-1.438	 	0.216	-3.075	4.75E-08	ACTA1,ALPL,AQP9,BIRC3,BTG2,C5AR1,CCL2,CCL3,CCL4L1/CCL4L2,CD36,CD86,CSRNP1,CXCL8,CYP2R1,DAAM2,DAPK2,DLEU1,FAM86C1,FCER1G,GCA,GIMAP6,GM2A,HIF1A,IFIT2,IL10RA,IL6,ITGAM,KIAA0513,LRRC25,LRRK2,LSP1,LY6E,MGP,MMP2,MMP9,MT2A,MYC,NCF2,PADI4,PGA5 (includes others),PHLDA1,PLEKHO2,POR,PPP1R16B,RARA,RARRES3,S100A8,SDCBP,SLC20A1,SLC25A15,SLC7A2,SMPD1,SP110,SPP1,THBS1,TNIP1,TSPAN14,TYROBP,VHL,VSIG4,XAF1	CTNNB1,EGR1,ERK1/2,FN1,HIF1A,ITGB1,JUN,NFKB1,NFKBIA,NFkB (complex),PDGFB,RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,TGM2	
P1	 	GnRH analog	 	biologic drug	 	-0.453	 	-0.020	-0.276	4.77E-08	ABCC1,ACACA,ACOT7,ACTN1,AHCYL1,AP3D1,ATF3,ATP6V1E1,BRE,C21orf33/LOC102724023,CAPNS1,CLOCK,COL6A1,CTNS,CYB5A,CYC1,DDOST,DUSP1,EIF4EBP1,ESR1,FCGRT,FGF2,FKBP1A,FOS,GABARAP,HDDC2,HELZ,HIF1A,HINT1,HSPA2,IFI27,IL11RA,JUN,LIMS1,MED24,MFAP5,MGMT,MICU1,MIPEP,MPV17,MTX1,MXRA7,N4BP1,NARS,NCBP2,NDRG1,NDUFS7,NFKBIA,NFX1,NR4A2,NTRK3,PHLDA2,PI4KA,PLD3,POLR3F,PPOX,PSMB7,PVR,RALA,RAN,RARA,RELN,RER1,SFRP1,SLC25A44,SLC2A3,SLC7A6,SMG5,SRSF3,TAF1C,TCEA1,THRA,TNK2,TPM1,TUBGCP2,UBE2M,VAT1,VPS52,WSB2,YIF1A,ZSWIM3	 	
P1	 	PRKAG3	0.016	other	 	 	 	 	 	4.82E-08	ANGPTL4,APBB3,ASPH,BTG2,CD36,CD55,CDH5,CELF2,CES1,CIDEC,CLCN3,CYP27A1,DDIT4L,DUSP10,EGR1,EIF4E2,GBE1,GLRX,GOT1,GPX3,HIST2H2AA3/HIST2H2AA4,HSPA5,ID1,IRX3,JUNB,KLF2,KLF4,LEP,LMCD1,MID1IP1,MMD,NEO1,ODC1,PHLDA3,PPP1R14B,RGCC,RHOU,RPE,SLC2A3,SLC4A3,SLC7A2,SORD,SOX17,TFRC,THRSP,TMEM100,TMEM37,TPPP3,ZFP36	 	
P1	 	STAT3	-0.484	transcription regulator	 	-0.800	 	0.208	-2.534	6.09E-08	ADIPOQ,ADM,AGT,ALAS2,ALDH1A1,ANGPTL4,ARG2,BCL2L1,BEX2,BMF,C5AR1,CAT,CCL2,CCL3L3,CCND2,CCR1,CD209,CD86,CDH2,CDH5,CEBPD,CFB,COL1A1,COL1A2,COL3A1,COL5A1,CTGF,CTSB,CXCL12,CXCL2,CXCL8,CXCR4,DDIT3,DVL3,EGR1,EGR2,EGR3,EPAS1,ESR1,FAM26F,FCER1G,FGF2,FOS,FSCN1,FST,GADD45A,HEY1,HIF1A,HIST2H2AA3/HIST2H2AA4,HMOX1,HP,IFI27,IFIT2,IL6,ISG20,ITGAM,JUNB,KAT2B,KDR,KLF4,LBP,LEP,LEPR,LTBR,LYZ,MAF,MAP2K5,MCL1,MMP2,MMP9,MYC,NDRG1,NFKBIZ,NOTCH1,NR4A2,NRP1,PEG10,PFKL,PHLDA1,PLA2G2A,PLA2G4A,PLAUR,POMC,PSMB5,PTGS2,RET,RNLS,ROR1,RUNX1,S100A9,S1PR1,SAA1,SERPINA3,SERPINE2,SGK1,SLC1A3,SMAD6,SOCS3,SP110,STC2,TAGLN,TFF3,TFPI2,THBD,THBS1,TIMP1,TNFRSF10B,TNFSF10,TRIM5,VCAN,WARS,XAF1,ZFP36	CEBPB,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT,STAT1,STAT3,TNF	
P1	 	Sos	 	group	 	 	 	 	 	6.18E-08	ABCC1,AKR1C3,ALDH1A3,ATP2C1,CAMK2D,CAST,CAT,CLIP1,CMTM4,COBLL1,COL16A1,CRABP2,DAPK2,DDX3X,DOCK1,ELOVL3,ELOVL6,ENAH,FLRT2,FOS,GBA,GKN1,GM2A,GSK3B,GSR,HMOX1,IRS2,KIF2A,KIF5B,KLF6,LARGE1,LRP8,MAOA,MAP3K20,MAP4K4,MPZL2,NDUFS7,NET1,ODC1,PFN1,PHLDA1,PKN1,PMEPA1,PTGS2,PTS,PTTG1,RAP1GAP,RFNG,RUNX1,SEMA3B,SMAD7,STX11,TIPARP,TNMD,TPP1,ZHX2	Ap1,CEBPB,FOS,HRAS,JUN,MAP2K1,MAPK8,Mek,NFkB (complex),RELA,Ras,SMAD3,SP1,SRF,STAT1,STAT3,Sos,TP53	
P1	 	PAX3	0.189	transcription regulator	 	0.831	bias	0.279	0.106	6.23E-08	ALDH3A2,ANOS1,AP3M2,ASNS,ASS1,ATN1,BCL2L1,BMP4,CLDN5,COL1A2,CST3,CSTF2,CTSA,CXCR4,CYP1B1,EGR2,EYA2,FHL1,FKBP1A,G0S2,G6PD,GLB1,GPR1,GSTM5,GUCY1A3,HARS,HLA-DRB1,ID3,ID4,IL6,KIAA0368,LIPE,MAP2K5,MCAM,MGP,MMP9,NEDD9,NNMT,PEA15,PKIA,PTPN3,RARRES2,RET,RHOB,SNRK,SRGN,SRSF3,TEK,TFPI2,TJP2,TSC22D1,TYRO3,VCAN,YARS,ZFP36L2	Ap1,JUN,Jnk,MYC,NFkB (complex),PAX3,RELA,SP1,STAT3,TP53,TP73	
P1	 	Pkc(s)	 	group	 	-1.960	bias	0.280	-3.768	7.33E-08	ACAT1,ADM,ARG2,ATF3,ATF6,BCL2L1,CCL2,CCND3,CD36,CD4,CD55,COL3A1,CTGF,CTSB,CXCL8,CXCR4,CYR61,DBP,DDIT3,DUSP1,EDN1,EGR1,EGR2,ERN1,FGF2,FOS,GADD45A,GADD45B,GAP43,HIF1A,HMOX1,HSPA5,IL6,JUN,JUNB,KCNJ2,KLF6,KRT8,MMP2,MMP9,NOX4,NQO1,NR1D1,NR4A2,NR4A3,PHLDA1,PPP1R15A,PTGS2,PTPRE,RARA,S100A1,S100A8,SLC6A9,SPP1,STC1,STC2,VCAM1	Ap1,CREB1,Ca2+,ERK1/2,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),Pkc(s),RELA,SMAD3,SP1,STAT3,TP53	
P1	 	SREBF1	0.063	transcription regulator	Activated	3.383	bias	0.331	1.600	7.51E-08	AARS,ACACA,ACLY,ACSL4,ADH1C,ADIPOQ,AK4,ALDOC,ATOX1,BCL2L1,BHLHE41,CDK4,CEBPD,COL6A1,CSAD,CYB5A,CYP51A1,DGKQ,DHCR7,ELOVL6,FAM189B,G6PD,GPAM,GPX3,GSR,HMGCS1,HMOX1,HSPA13,HSPA1A/HSPA1B,HSPA5,IDH1,IL6,IMMT,IRS2,LDLR,LEP,LPIN1,LSS,MSMO1,MVD,NCF2,PCK2,PLS3,PTGDS,PTGS2,RPLP0,RPS24,SQLE,STX1A,STXBP1,TF,THRSP,TM7SF2,TMEM97,UCP2	CEBPA,CEBPB,D-glucose,FOS,FOXO1,Growth hormone,HIF1A,Ins1,Insulin,MYC,PPARA,PPARG,PPARGC1A,RELA,SCAP,SREBF1,SREBF2,STAT3,Srebp,TP53	
P1	 	ELK1	0.578	transcription regulator	 	-0.805	bias	0.420	-2.486	8.07E-08	BCL2L1,BMP2,CCT8,EGR1,EGR2,ELK1,FOS,JUN,JUNB,MCL1,MECOM,MMP9,MTHFD2,MYLK,NUPR1,PTGS2,SPP1,TAGLN,THBS1,TIPARP,TNFRSF10B,ZFP36	Ap1,ELK1,ERK,ESR2,FOS,JUN,MAPK3,MKL1,MKL2,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SRF,STAT3,TNF	
P1	 	IL3	0.074	cytokine	 	-0.507	bias	0.362	-2.763	8.83E-08	ALDH2,ATF5,BCL2L1,BIRC3,BMP2,BNIP3L,BTG2,C1QA,CAT,CCL2,CCND2,CCND3,CCT5,CD14,CD69,CD86,CEBPG,CIAPIN1,CRAT,CSF1R,CXCL8,CXCR4,DDIT3,DHPS,DOK2,EGR1,EGR2,EGR3,EMP3,FCER1A,FCER2,FOS,GADD45A,GADD45B,HBEGF,HDGF,HK1,HRSP12,HSPA2,HSPA5,HSPA9,IL6,IMPDH2,ITGAM,JCHAIN,JUN,JUNB,KLF9,LAMP3,LYN,MAN2B1,MCL1,MLF2,MS4A2,MYC,NARS,NCL,NEDD9,NOTCH1,NRP1,ODC1,ORMDL3,PDE1B,PFKL,PSMB7,RALA,RAN,RPL6,SELE,SERPINA3,SLC2A3,SLC3A2,SOCS3,SPI1,TARS,TNFRSF4,TNFSF10,TPSAB1/TPSB2,UCP2,VCAM1	Ap1,CEBPA,CEBPB,IL10,IL3,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,STAT3,TP53	
P1	 	CD 437	 	chemical drug	Inhibited	-4.245	bias	-0.418	-1.154	8.91E-08	AK2,AKR1B1,ALDOA,AP2M1,AP2S1,ARL2,ARSA,BANF1,CCT3,CDK4,COX7A2L,ENO1,FOS,FSCN1,FTH1,GADD45A,GDF15,HADHA,HSPA8,INO80B,ITGA11,JUN,KPNA2,MAN1B1,MTCH2,MYC,NARS,NDUFB9,NFKBIA,NME1,ODC1,PCBP2,PFN1,PIN1,PLP2,PNPLA6,POLR2G,PSMA4,RASL10B,RPL8,RPLP1,RPS2,S100P,SLC25A6,SLC38A7,SNRPB,SRGN,SRSF3,STOML2,TIMM8B,TNFRSF10B,TXN,UBE2M,UQCRH,WDR45,XRN2	Ap1,CD 437,CEBPA,E2F1,FOS,HIF1A,JUN,Jnk,MAPK8,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TP53	
P1	 	tributyrin	 	chemical drug	Inhibited	-3.250	bias	0.470	-5.625	9.81E-08	ADM,ADRB2,AKAP12,ATF3,BIRC3,CCL2,CD55,CTGF,CXCL8,CXCR4,CYR61,DUSP1,DUSP14,EDN1,ETS1,GBP1,HBEGF,HSPA5,ID3,IL6,MME,NDRG1,PTGS2,SAMD4A,TNFAIP3,TUFT1	Ap1,CTNNB1,HDAC1,HDAC2,HDAC3,HDAC4,HIF1A,NCOR2,NFE2L2,NR3C1,PPARG,RELA,SIN3A,SNAI1,SP1,STAT1,STAT3,TP53,tributyrin	
P1	 	CREBBP	-0.164	transcription regulator	 	0.154	bias	0.328	-1.734	1.03E-07	AGT,AKAP12,AMHR2,ANGPT1,AP3M2,AQP11,ATF6,CAMK2D,CAPG,CCND2,CCND3,CDH5,CLOCK,COL1A2,CORO2B,CRISPLD2,CTSG,CXCL12,CXCL8,CXCR4,CYP11A1,CYR61,DHRS3,DNAJB4,DUSP22,EGR1,EGR2,EGR3,ELANE,EPN1,ERCC1,ESAM,EYA2,FGF2,FOS,FOSB,FRMD4A,GM2A,GNG2,HDAC11,HLA-G,HMGCS1,IL10RA,IL17RC,IL18RAP,IL6,JUN,KCTD1,KLF2,LDLR,MAF,MAFG,MAP3K8,MGMT,MIA,MMP9,MST1,MYC,MYH1,NDRG1,NOTCH1,NPAS2,NR4A2,NR4A3,NTRK3,PDE3B,PLEKHF1,PPFIBP2,PRKCD,PTGS2,PTPRF,RGL1,RNF157,SDC4,SELE,SERPINA3,SERPINE2,SOCS3,STOM,TAGLN,TANC2,THRSP,TIPARP,TNFAIP3,TNFRSF10B,TNFSF10,VCAM1,WNT5B,ZFP36L2	CEBPA,CEBPB,CREBBP,EP300,HDAC1,HIF1A,Hdac,Histone h4,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,STAT3,TP53	
P1	 	carbon tetrachloride	 	chemical toxicant	 	0.443	bias	0.318	-1.717	1.07E-07	ABCC1,AK4,AOX1,APOB,APOE,ASS1,ATF3,BCL2L1,CA3,CAT,CCL3L3,CCR1,CEL,COL1A1,COL1A2,COL3A1,CTGF,DDIT3,DUSP1,FAAH,FKBP1A,FOS,GADD45A,GADD45B,GDF15,GSTM1,HDGF,HMOX1,IGF2R,IGFBP6,IL6,INHBE,JUN,JUNB,KDR,ME1,MMP2,MMP9,MYC,NQO1,ODC1,PDGFD,PPP1R15A,PRNP,PTGS2,RGN,S1PR3,SMAD7,SORD,SPHK2,SPP1,TF,TGFBR2,TIMP1,TNFRSF12A,VCAM1	Ap1,IFNG,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,carbon tetrachloride	
P1	 	prostaglandin E2	 	chemical - endogenous mammalian	 	-1.216	 	0.164	-2.445	1.08E-07	ABCG1,ADAMTS1,ANGPT1,ANGPTL4,ATF3,BCL2L1,BIRC3,BMP2,BTG1,C5AR1,CCL13,CCL2,CCL3,CCL3L3,CCL8,CCR1,CD14,CD55,CD69,CD86,CEBPD,COL1A1,CTGF,CXCL12,CXCL8,CXCR4,CYTIP,DUSP1,EGR1,EGR2,ERBB2,ETS1,FOS,FOSB,FST,HDC,HIF1A,HMOX1,IDO1,IER3,IGFBP4,IL6,ITGAM,JUN,LMNA,MCL1,MMP2,MMP9,MYC,NEDD9,NFKBIA,NR4A2,NR5A2,NRP1,PLA2G4A,PTGER4,PTGS2,RAB5A,S100A8,SOCS2,SOCS3,ST3GAL3,ST3GAL4,ST6GALNAC2,TGFBR3,THBD,THBS1,THRSP,TJP1,TRAP1,UCP2,VEGFC	CREB1,CSF2,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TNF,prostaglandin E2	
P1	 	dalfampridine	 	chemical drug	Inhibited	-3.638	bias	0.439	-5.447	1.12E-07	ATF3,BTG2,CYR61,DUSP1,EGR1,EGR2,FOS,FOSB,GADD45B,HSPA8,IER2,JUN,JUNB,KLF4,NR4A2,PTGS2,TIPARP	Ap1,CREB1,FOS,JUN,L-glutamic acid,MAPK8,Muscarinic cholinergic receptor,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,dalfampridine	
P1	 	curcumin	 	chemical drug	 	0.393	 	-0.193	1.979	1.16E-07	ABCC1,ABCG1,ADAM17,ADIPOQ,APOE,ATOX1,AXIN1,AXL,BCL2L1,BIRC3,CAV1,CCL2,CCND2,CCND3,CD24,CD36,CD86,CDK4,COL1A1,COL1A2,CTGF,CXCL8,CXCR4,DDIT3,DIABLO,DLG4,EDN1,EGR1,ERBB2,ETS1,FASTK,FGF2,FOS,FOSB,FTH1,FYN,GCLM,GLUL,GNA11,GSK3B,GSR,HELZ,HIF1A,HMOX1,HSPA1A/HSPA1B,HSPA8,IGFBP4,IL6,ITGAM,JUN,JUNB,KLF9,LEP,LSP1,MCL1,MIF,MLF2,MMP2,MMP9,MTOR,MYC,NEO1,NFKBIA,NOTCH1,NQO1,PTGIS,PTGS2,SELE,SFTPD,SMAD7,SOCS3,SOX9,TACC2,TCEB2,TESK1,TFRC,TGFBR2,TNFRSF10B,TOB1,UBE2E2,UCP2,VCAM1	Ap1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF,curcumin,reactive oxygen species	
P1	 	SP3	-0.308	transcription regulator	 	0.402	 	0.239	-0.683	1.28E-07	AEBP1,AKAP12,ASNS,ATF3,BMF,CBS/CBSL,CDH2,CDKN2C,CES1,COL1A1,COL1A2,COL7A1,CYP51A1,DUSP1,EGR1,ESR1,FOS,GDF15,HSD11B2,HSPA5,IGFBP3,IRF3,JUN,KDR,KLF4,LDLR,LHCGR,MMP2,MYCN,MYH11,MYLK,NCF2,NPTXR,NR5A2,PADI4,PKM,PLAUR,PRKCD,PROCR,PTGS2,PTTG1,RASGRP2,SERPINH1,SGK1,SLC19A1,SLC2A3,SLC39A8,SLC4A7,SPARC,SRC,TAGLN,TGFBR2,TGFBR3,TIMP1,TNFRSF4,TXNRD1	Ap1,CTNNB1,ESR1,HDAC1,HDAC2,Histone h3,JUN,NFATC2,NFkB (complex),Nfat (family),RELA,RNA polymerase II,Ras,SIN3A,SP1,SP3,STAT1,STAT3,TP53	
P1	 	SFTPA1	0.047	transporter	Activated	3.051	 	-0.172	3.956	1.30E-07	ADRB2,ANGPTL4,ANKRD35,CCL3,COL1A1,CTGF,CXCL2,CYP1B1,CYR61,EGR1,ERN1,FOS,FOSB,GFPT2,GSTO2,GUCY1A3,HBEGF,IL6,KLF2,LOX,MAP1B,MYC,PDK4,PHLDA1,PLIN2,RASD1,SFRP2,TCEA3	ARRB2,Ap1,HIF1A,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,SFTPA1,STAT3,TNF,TP53,lipopolysaccharide	
P1	 	trichostatin A	 	chemical drug	 	-1.625	bias	0.283	-4.218	1.31E-07	ABHD5,ADAMTS1,ADCY1,AGT,AKAP12,ALPL,ANGPT1,APOE,ATP5I,BCL2L1,BMP2,BMP4,BRMS1,BTG1,C1QTNF6,CA12,CAST,CCND2,CD14,CD86,CDKN1C,CDKN2B,CLEC3B,COCH,COL1A2,COL6A3,COLEC12,CPA3,CSF3R,CSTF2,CTPS1,CXCL8,CXCR4,CYP1B1,CYP2C8,CYP4B1,DDT,DNASE1L3,DOK2,DPM2,DUSP1,ENPP2,ERBB2,ESR1,FAM127A,FOS,FOXC1,FRZB,G6PD,GADD45A,HDAC11,HIF1A,HLA-DRB1,HMGCS1,HSD11B2,ID1,ID3,IGFBP3,IGSF1,IL10RA,IL6,ING1,ITGA1,ITGAM,JCHAIN,KDR,KIT,LAGE3,LAMA2,LDLR,LEPR,LGMN,LHCGR,LIMA1,LMNA,LRP8,MAF,MGMT,MMP9,MNDA,MT1L,MYC,MYCN,MYOF,NDRG1,NFKBIA,NOTCH1,NRP1,PLCE1,PPRC1,PRKCD,PRNP,PRSS23,PSMB2,PTGS2,RARA,RBBP8,RCL1,RELN,RERG,SELE,SEMA3C,SFRP1,SFRP4,SGK1,SGPL1,SHC1,SIAH2,SLC7A8,SQSTM1,TAGLN,TFPI2,TGFBR2,TGM2,THBS1,TIMP1,TNFRSF10B,TNFSF10,VCAM1,VEGFC,VHL	Ap1,CTNNB1,EGR1,ESR1,HDAC1,HDAC2,IL6,MECP2,MYC,NFkB (complex),RELA,RNA polymerase II,SIN3A,SMAD3,SP1,STAT1,STAT3,TP53,decitabine,trichostatin A	
P1	 	IKBKB	0.233	kinase	 	0.009	bias	0.346	-2.659	1.32E-07	AEBP1,ATF3,BCL2L1,BIRC3,BMP2,CCL2,CCL3,CCL3L3,CCR1,CEBPD,CH25H,CTSB,CTSK,CXCL12,CXCL2,CXCL8,CXCR4,CYBA,CYP1B1,EDN1,EGR1,ENPP2,ETS1,FOS,FYN,GADD45A,GM2A,GRK5,GRN,HIF1A,HMOX1,IGFBP6,IL6,JUNB,LIPE,MBP,MGP,MMP2,MMP9,MYC,MYO1D,NAGLU,NFKBIA,NGF,OGN,PCDH7,PLA2G4A,PLD3,PLIN1,PTGS2,PTX3,RCAN1,RGS16,SELE,SEMA3C,SERPINE2,SFRP1,SGK1,SLC16A2,SOCS2,SOCS3,TGFBR2,TNFRSF4,VCAM1,VCAN	CHUK,IKBKB,IKBKG,IL1B,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,TP53	
P1	 	EIF4E	0.219	translation regulator	Activated	3.965	bias	0.501	 	1.34E-07	ATOX1,BCL2L1,CAPG,CDC34,CDK4,CHMP1A,DGUOK,DPYD,EIF4EBP1,FASTK,FGF2,GPS1,GPS2,GPX3,HIF1A,HMOX1,HRAS,IGFBP4,KAT2B,LSM10,LSM4,LSM7,MCL1,MIA,MPV17,MYC,NFKBIA,NHP2,NOL3,NRP1,ODC1,PA2G4,PIN1,PLAUR,PRDX5,SERTAD1,SRXN1,TP53BP1,TRIP6,UPP1,VEGFC,ZPR1	CREB1,Ca2+,EIF4E,JUN,Mek,NFkB (complex),RELA,Ras,SP1,SRF,STAT1,STAT3,TP53	
P1	 	bromobenzene	 	chemical toxicant	 	1.093	 	0.011	1.048	1.37E-07	ABCC1,ABCC3,CDO1,DDIT3,FMO1,FMO3,FOS,GADD45A,GAPDH,GOT1,GSR,GSTM1,HMGCS1,HMOX1,HSPA13,HSPA5,JUN,LONP1,MSMO1,MYC,NQO1,NUPR1,POR,PPP1R15A,TIMP1,TSC22D1,TUBB2B	 	
P1	 	TCF	 	group	 	-1.715	bias	0.501	 	1.40E-07	ADGRG2,ALDH1A1,ALDH3A2,BCL2L1,BMP4,CCT8,CNN2,CRAT,EGR1,EPHB3,F13A1,FOS,ID3,IDO1,INHBB,ITGA1,JUNB,LHCGR,MME,MMP2,MT1L,MYC,PLS3,PTGS2,QPCT,RCN1,SAA1,SEMA3C,SERPINA3,SLC1A5,TSC22D1	Ap1,CREBBP,CTNNB1,Creb,EP300,ESR2,FOS,HDAC1,JUN,NFkB (complex),PPARG,RELA,SP1,STAT1,STAT3,TCF,TP53	
P1	 	okadaic acid	 	chemical toxicant	 	-1.859	 	0.163	-2.734	1.40E-07	ALDH3A1,BCL2L1,CCND2,CCND3,CCNG2,CDK4,CRABP2,CXCL2,CXCL8,CYP1B1,EGR1,ELN,ESR1,FOS,FOSB,IL6,JUN,JUNB,KLF4,MAP3K8,MCL1,MMP9,MYC,NDRG1,ODC1,PTGS2,SAA1,SPP1,SQSTM1,SRSF3,THRSP	Akt,ELK1,ERK,ERK1/2,FOS,HIF1A,JUN,MAPK3,Mek,NFKBIA,NFkB (complex),RELA,SMAD3,SRF,STAT1,STAT3,TP53,okadaic acid	
P1	 	SB203580	 	chemical - kinase inhibitor	 	0.917	bias	-0.411	4.508	1.60E-07	ADIPOQ,ADRB2,AGT,ALPL,ANXA3,AQP9,ATF3,BMP2,BMP4,CCL2,CCL3,CCL8,CD55,CD86,CDH2,CEBPD,CLDN5,COL1A1,COL1A2,COL3A1,CTGF,CTSK,CXCL8,CYP1B1,CYP26B1,DCHS1,DDIT3,DUSP1,EGR1,ENO1,ERP29,ETS2,FCER2,FOS,FOSB,GADD45A,GLRX,HCAR3,HIF1A,HMOX1,HSPA5,IDO1,IER3,IFI27,IFIT2,IGFBP3,IL6,ISG20,ITGAM,JUN,JUNB,KDR,LIMS1,MMP2,MMP9,MYC,MYH11,NQO1,PLAT,PLAUR,POMC,PPP1R15A,PTGDS,PTGS2,RARRES3,RCN3,RUNX1,SELE,SGK1,SLC20A1,SOCS3,SPARC,SPP1,STC2,TAGLN,TGM2,THBS1,TIMP1,TNFSF10,TYMP,UCP2,VCAM1,VEGFC	Ap1,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SB203580,SP1,STAT1,STAT3,TNF	
P1	 	TGFB2	0.382	growth factor	 	0.003	 	0.174	-0.951	1.73E-07	ANGPTL4,BMP4,CD36,CD59,CDH5,CNN1,COL1A1,COL1A2,COL3A1,CTGF,EDN1,EGR1,EGR2,FGF2,FOS,HBEGF,HEY1,HMOX1,ID4,KDR,LIPG,MMP9,NGF,NOTCH1,OSR1,PDK4,RUNX1,S100A8,SPP1,TAGLN,TGFBR3,THBS1,TIMP1,VCAN	Ap1,CEBPA,CEBPB,FGF2,JUN,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TGFB1,TGFB2,TP53,Tgf beta	
P1	 	Hdac	 	group	 	1.347	 	-0.018	1.461	1.82E-07	ADAMTS1,ATF3,BMP2,CCNG2,CRABP2,CSF1R,CSF2RA,CXCL8,CXCR4,DDIT3,DKK3,EDN1,EDNRA,EGR1,EGR3,EMX2,ERBB2,FOS,GADD45B,HIF1A,IGFBP3,IL6,IRX3,JUN,KLF6,KLF9,MEOX2,MT1E,MT1F,MYC,MYCN,NRP1,OSR1,RNASE1,RRM2B,SEMA3C,SFRP1,SFRP2,SMO,SPP1,SPRY1,SPRY2,TGFBR2,THBS4	ARNT,Ap1,CTNNB1,EGR1,ESR1,HDAC1,HDAC2,HIF1A,Hdac,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SIN3A,SMAD3,SP1,STAT3,TNF,TP53,TP73,VHL	
P1	 	FN1	0.319	enzyme	 	-1.050	bias	0.281	-2.898	1.86E-07	ACP5,AHCY,APOE,BIRC3,BNIP3L,CANX,CAPN2,CCL2,CDH2,CDK4,COL1A1,CTSD,CXCL2,CXCL8,DDX3X,DHCR24,DLGAP4,EPB41L1,FGF2,FLNA,FOS,G3BP2,GFRA2,HK1,IL6,ITGA1,ITGAM,LIMS1,MGP,MMP2,MMP9,MTOR,MYC,NFKBIA,PLAUR,PREB,RNF125,RRAGD,SCRN1,SDC4,SDCBP,SLC9A1,SOCS3,SOX9,SPARC,SPP1,SQSTM1,SURF1,TAGLN,TGFBR2,TGM2,THBS1,TNFRSF10B,TNIP1,VPS4A	Ap1,CEBPB,CTNNB1,EGR1,ESR1,FN1,HIF1A,ITGB1,JUN,Jnk,MAP2K1,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	AR	-0.254	ligand-dependent nuclear receptor	 	-0.258	bias	0.329	-2.817	1.93E-07	ABCG1,ACTA1,ADM,AKR1C3,ALDH1A1,AMHR2,ATP2A2,BCL2L1,BMF,CA4,CASQ2,CAST,CAV1,CCL3L3,CDCA5,CDH2,CHTF18,CKAP4,CLGN,COL3A1,CXCL12,CYC1,CYP11A1,DDT,DHCR24,DHCR7,DNM1L,EDN1,EDNRA,EGR1,EPAS1,EPB41L4B,EPHX1,ERBB2,ERN1,ETS2,FAM174B,FKBP4,GDF15,GDI1,GSTM1,GUCY1A3,GUSB,HSPA5,HSPB7,IGFBP3,IL6,IMPDH2,KCNJ2,KPNA2,LAMC3,LHCGR,MAD2L2,MAOA,MCM2,MME,MSMO1,MT1X,MTHFD2,MYC,MYL3,NDRG1,NOTCH1,NUPR1,NUSAP1,ODC1,PCMT1,PDIA5,PLAT,PLS3,PMEPA1,POMC,PRKCD,PTGDS,RARRES1,RHOB,S1PR3,SCAP,SGK1,SLC2A3,SLC39A8,SORD,SOX9,SRD5A1,STK39,TACC2,TF,TFF3,TGFBR2,THBS1,TJP1,TMEM158,TNFRSF12A,TRMT12,VCAN	AR,ATF2,CEBPB,CREB1,CREBBP,CTNNB1,Creb,EGFR,EP300,ESR1,FOXO1,HIF1A,IGF1,JUN,MYC,NFkB (complex),RNA polymerase II,SMAD3,SP1,STAT3,TP53,dihydrotestosterone,metribolone,testosterone	
P1	 	CAT	-0.506	enzyme	 	-1.369	bias	-0.261	-0.193	1.93E-07	ADM,AGT,ATG7,CAV1,CCL2,CD36,CD69,COL1A1,CXCL8,CYP1B1,HIF1A,HMOX1,HSPA4,IL6,MCL1,MMP9,PTGS2,THBS1,TIMP1,TNFRSF10B,VCAM1,XAF1	Akt,Ap1,CAT,CEBPA,CEBPB,ERK,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	troglitazone	 	chemical drug	 	-0.388	 	0.048	-0.776	1.98E-07	ABCG1,ACADM,ACTA1,ADIPOQ,AGT,AK2,ALAD,ANGPTL4,ATF3,ATP2B1,AXIN2,BCL2L1,BIRC3,CARS,CAV1,CCL2,CCL3,CCND2,CCND3,CD36,CD59,CD86,CDK4,CDKN2C,CEBPD,CEBPG,CHCHD10,CIDEC,COL15A1,COL1A1,COL1A2,CXCL8,DDIT3,DHRS3,EGR1,EIF5,ELK1,ETS1,FOS,G0S2,GADD45A,GDF15,GPAM,HIPK2,HMOX1,HSPA5,IFRD1,IL6,ITM2A,JUN,KLF4,LEP,LIPE,LOC102724788/PRODH,MCL1,ME1,MGMT,MME,MMP9,MT1G,MYC,MYH11,NAGK,NDRG1,NFKBIA,NNMT,NR4A3,PC,PDE3B,PDK4,PLEC,PLIN1,PLIN2,PNRC2,PTGS2,RASD1,SELE,SLC27A1,SLC9A1,SORBS1,SPOCD1,SPP1,TALDO1,THRSP,TRIB3,UCP2,VCAM1	D-glucose,FOXO1,Growth hormone,HIF1A,Insulin,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TNF,troglitazone	
P1	 	sphingosine-1-phosphate	 	chemical - endogenous mammalian	Inhibited	-2.801	 	0.245	-4.084	2.09E-07	ANGPT1,CCL2,CD36,CTGF,CXCL2,CXCL8,EGR1,ENPP2,ERN1,ETS1,FGF2,FOS,GAP43,HIF1A,IL6,JUN,LEP,MMP9,PLA2G2A,PRPH,PTGS2,RARA,S1PR1,S1PR3,SELE,TAGLN,THBS1,TIMP1,VCAM1,VEGFC	Akt,Ap1,CREB1,FOS,HIF1A,IL6,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,STAT3,TP53,sphingosine-1-phosphate	
P1	 	SP600125	 	chemical - kinase inhibitor	 	0.869	 	-0.213	2.395	2.63E-07	ACAT2,ADM,AKR1C3,APOE,ATF3,BCL2L1,CCL2,CCL3,CD86,CIDEC,COL1A1,COL7A1,COL8A1,CSF1R,CSPG4,CTGF,CXCL16,CXCL2,CXCL8,CYR61,DDIT4,DSG2,EGR1,ERCC2,FOS,FOSB,GADD45A,HIST2H2AA3/HIST2H2AA4,HMOX1,IL6,ITGA3,JUN,JUNB,LDLR,LEP,MCL1,MMP9,MTHFD2,P4HA2,PCK2,PLA2G4A,PLEC,PTGDS,PTGS2,PTX3,SELE,SGPL1,SMPDL3A,SOCS3,SPP1,THBS1,TNFRSF10B,TPM1,VCAM1,ZFP36	Ap1,ERK1/2,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,SP600125,STAT3,TGFB1,Tgf beta	
P1	 	CCL5	0.274	cytokine	 	-0.706	bias	0.457	-3.006	2.68E-07	ALCAM,ATF4,C5AR1,CAPN2,CCL2,CCL3,CCL3L3,CCR1,CD163,CXCL2,CXCL8,CYP1B1,DUSP1,EMP1,FOS,HDC,HMGA1,IER2,IL6,LIMS1,MMP9,PLAUR,PLEC,PTGDS,SGK1,SQLE,ZFP36	CCL5,CEBPA,CEBPB,ERK1/2,IFNG,IL10,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TNF,TP53	
P1	 	miR-16-5p (and other miRNAs w/seed AGCAGCA)	 	mature microrna	Inhibited	-2.635	bias	-0.501	 	2.70E-07	ABHD10,ACP2,ACTR1A,ARHGDIA,ARL2,ASXL2,ATF6,ATG9A,CA12,CAPRIN1,CARD8,CCND2,CCND3,CRHBP,DNAJB4,DTD1,ECHDC1,FGF2,GFM1,GFPT1,GPAM,GRN,H3F3A/H3F3B,HARS,HMGA1,HMOX1,HRSP12,HSPA1A/HSPA1B,IFRD1,IGF2R,IPO4,JUN,MCL1,NPR3,PDCD4,PHLDB2,PLAG1,PSAT1,PTGS2,RTN4,SERPINE2,SLC12A2,SLC25A22,SLC38A1,SLC7A1,SPI1,SQSTM1,SRPRA,SRPRB,TOMM34,TPPP3,UCP2,VTI1B,YIF1B	 	
P1	 	ERG	-0.185	transcription regulator	 	0.769	bias	0.416	-1.611	2.76E-07	ACTN1,ADGRG1,ADRB2,APOC1,ARHGAP17,ARHGAP20,ARHGAP28,ARHGAP4,ARHGEF2,ARHGEF6,AXIN2,BIRC3,CD59,CDC42BPB,CDK5RAP2,CLIP1,COLGALT1,CXCL8,CXCR4,DAAM1,DOCK1,EPB41L3,ETS1,FAM174B,FHL1,FLNC,FOSB,FYN,GUCY1A3,IKBKG,MMP9,MYCN,MYO10,MYO1D,MYO5A,NDRG1,NLGN1,NR4A2,PARVA,PLAT,PLAUR,RAPGEF5,RAPH1,RCAN2,RPA1,RSU1,SLIT2,SPARC,SPP1,TGFBR2,THBS1,TRIOBP,WASF3	Akt,Ap1,BRAF,ELK1,ERG,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NFkB (family),RELA,SP1,SRC,STAT3,TP53	
P1	 	mycophenolic acid	 	chemical drug	Inhibited	-3.278	bias	0.320	-5.022	2.82E-07	ADM,ADRB2,AKAP12,ATF3,BIRC3,CCL2,CCND2,CCND3,CD55,CD59,CTGF,CXCL8,CXCR4,CYR61,DUSP1,DUSP14,EDN1,ETS1,GBP1,GNL3,HBEGF,HSPA5,ID3,IL6,LDLR,MME,PTGS2,SAMD4A,TNFAIP3,TUFT1	ALB,Ap1,EDN1,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,SQSTM1,STAT3,mycophenolic acid	
P1	 	FOXO3	0.407	transcription regulator	Inhibited	-2.544	 	0.212	-3.807	2.90E-07	ALDH3A1,BNIP3L,CAT,CCND2,CCNG2,CDK4,CDKN1C,CDKN2B,CTGF,CXCL8,CYR61,DDIT3,DDIT4,DOK5,EGR1,EGR2,EIF4EBP1,ESR1,FOS,FOSB,GABARAPL1,GADD45A,GADD45B,GLUL,GRB14,GSTM5,IARS,IER3,IL6,IMPDH2,IRS2,JUNB,LARS,MMP9,MTHFD2,MYC,NFKBIA,NOL3,PDE3B,PPP1R15A,PRDX5,PRNP,SGK1,SLC1A4,SLC7A1,TNFSF10,TXNRD2,UCP2	AR,ATF4,E2F1,EGR1,FOXO1,FOXO3,JUN,MAX,MXI1,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SIRT1,SP1,STAT3,TP53,TP73	
P1	 	sodium arsenite	 	chemical drug	 	1.619	 	0.131	1.062	2.92E-07	ABCB6,ABCC1,AHCY,CBS/CBSL,DDIT3,EGR1,ESR1,FOS,FTH1,GADD45A,GADD45B,GCLM,GSS,HIF1A,HMOX1,HSPA4,JUN,LITAF,RND2,SOCS3,TNFRSF10B,TNFSF10	Ap1,CEBPA,CEBPB,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TP53,sodium arsenite	
P1	 	CSF2	-0.046	cytokine	 	0.971	bias	0.388	-2.467	3.06E-07	ABCG1,ACP5,BCL2L1,BIRC3,BSG,C5AR1,CCL18,CCL2,CCL3,CCL3L3,CCND3,CCR1,CD14,CD1C,CD209,CD24,CD276,CD69,CD86,CDC20,CDCA5,CDKN2B,CDKN2C,CHTF18,COL8A1,CSF1R,CSF2RA,CXCL2,CXCL8,CXCR4,DDIT3,DOK2,EDN1,EFEMP2,EGR1,EGR2,EGR3,ELN,FAM65B,FOLR2,FOS,GADD45GIP1,GCLM,GDF15,HBEGF,HCAR2,HCAR3,HDC,ID3,IDO1,IER3,IL6,ITGAM,LAMP2,LEP,LY96,MAP3K20,MARCO,MCL1,MMD,MME,MMP2,MMP9,MNS1,MYC,NET1,NFKBIA,NLRP3,NR4A2,NRP1,NUSAP1,ODC1,PDE1B,PLA2G15,PMP22,POLD1,PPP1R15A,PRNP,PTGER4,PTGS2,QSOX1,RARA,RBBP9,RRM2B,SGK1,SLC1A5,SNTB1,SOCS2,SOCS3,SPI1,SPP1,SQSTM1,TGM2,THBS1,TNFAIP3,TNFRSF4,UPP1,UTP11,ZFP36	Ap1,CSF2,IFNG,IL4,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,STAT6,TNF	
P1	 	SRC	0.609	kinase	 	0.218	 	0.236	-1.071	3.08E-07	ACAT1,BCL2L1,CAV1,CCL2,CCND2,COL1A2,CTSB,CXCL8,DUSP1,ENO1,ERBB2,FOS,GBP1,HIF1A,HMOX1,ID1,IL6,JUN,LAMP2,LDLR,MCL1,MMP2,MMP9,MYC,NQO1,NQO2,PLAUR,PRKCD,PRKCE,PTGS2,SLC4A7,SPP1,SRC,TFPI2,TJP1,VCAM1,VEGFC	Akt,CEBPB,CREB1,CTNNB1,ERK1/2,HIF1A,JUN,MAP2K1,NFKBIA,NFkB (complex),P38 MAPK,PIK3R1,RELA,SMAD3,SP1,SRC,STAT3,TP53	
P1	 	trans-hydroxytamoxifen	 	chemical drug	 	-1.151	 	-0.116	-0.447	3.08E-07	ALDH4A1,ANXA3,BMP4,CBX6,CD24,COL4A5,CTSH,CXCL12,CYP1B1,DDIT4,DUSP1,EGR3,EPB41L3,ERBB2,HIST2H2AA3/HIST2H2AA4,IER3,IGFBP4,INHBB,KIAA0922,KLF6,LHFPL2,LITAF,MATN2,MMD,NDRG1,PPP1R3C,PRSS23,RAP1GAP,SIAH2,SLC22A5,SLIT2,SMPD1,SRD5A1,STC1,STXBP1,TM4SF1,TPM1	ESR1,ESR2,FOS,JUN,NFKB1,NFkB (complex),SP1,STAT3,trans-hydroxytamoxifen	
P1	 	ethanol	 	chemical - endogenous mammalian	 	1.496	 	0.143	0.284	3.42E-07	ABCG1,ACACA,ACADM,ACLY,ACTA1,ADAM17,ADH1C,ADIPOQ,ADM,ADRBK1,ALDH1A3,ATF3,BCL2L1,BMP4,C5AR1,CAPN5,CAT,CCL2,CD14,CEBPD,COL1A2,COL3A1,CTGF,CXCL8,CXCR4,CYP2C8,DDIT3,DUSP1,EDN1,EGR1,ELOVL3,EPHX1,ESR1,FAAH,FAM46A,FOS,FOSB,GADD45A,GDE1,GNAI1,GPAM,GSR,HEY1,HIF1A,HMOX1,HOMER2,HSPA5,ID1,IL6,ITGAM,JUN,LPIN1,LSS,MAP1B,MBP,MCOLN1,MME,MMP2,MMP9,MYC,NCF2,NQO1,ORM1,PHLDA2,PLAT,PLIN1,POMC,PPP1R1B,PPP1R3C,PTGS2,RARRES2,RGCC,RHOB,SELE,SGK1,SPTBN1,SQLE,SRXN1,STIM1,TFF3,TFPI2,TIMP1,VCAM1	Ap1,CEBPB,HIF1A,IGF1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNF,ethanol,reactive oxygen species	
P1	 	CD38	-0.017	enzyme	 	1.320	bias	0.436	-1.537	3.46E-07	ALDOA,ALDOC,ASNS,ASS1,B4GALT7,BNIP3L,CCND2,CD86,CKAP4,CLCN3,CRIP1,EIF4EBP1,FAM162A,GALK1,GBE1,GBP4,GCAT,GLIPR2,GPAM,HIGD1A,IL6,JCHAIN,KIAA1147,MYADM,NABP1,NDRG1,PFKL,PKM,PSAT1,PYCR1,RAP1GAP,RASGRP2,RBPMS,RRAS2,SDF2L1,SLC39A8,SLC7A5,SOCS2,SOCS3,STK39,THY1,TMED5,TMEM97,TUBB2B,VCAM1	Akt,CD38,CEBPA,CEBPB,FOS,HIF1A,IFNG,Ins1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,STAT1,STAT3,TP53	
P1	 	nitrofurantoin	 	chemical drug	Activated	2.052	 	0.064	1.617	3.51E-07	ACADM,ACADVL,ADAMTS1,ANXA5,APOE,ASNS,ASS1,BCL2L1,BTG2,CAPN2,CAPN6,CAT,CCL3L3,CES1,CST3,CTSB,DDIT3,ERBB2,GADD45A,GPNMB,GSR,GSS,GSTM1,GSTM3,HMGCS1,HMOX1,HSPA5,ID1,IER3,IFRD1,IGFBP3,IL6,LBP,LOX,MYC,NFKBIA,NQO1,ODC1,ORM1,PLAT,RPL6,SPP1,TIMP1,TNFRSF12A,TUBB,TXN,VCAM1	 	
P1	 	Pdgf (complex)	 	complex	 	0.055	bias	0.301	-1.542	3.89E-07	CAV1,CCL2,CCND2,CDKN2B,CYBA,EDN1,EGR1,FAM189B,FGF2,FOS,FOSB,HEY1,HEY2,HIF1A,HMOX1,IRS2,JUN,JUNB,LDLR,MEOX2,MMP2,MYC,NOTCH1,NOX4,NR4A2,ODC1,PLAUR,PTGS2,SPARC,THBD,TIMP1,VCAM1	EDN1,ERK,ERK1/2,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,Pdgf (complex),RELA,Ras,SMAD3,SP1,STAT1,STAT3	
P1	 	benzyloxycarbonyl-Leu-Leu-Leu aldehyde	 	chemical - protease inhibitor	 	1.363	 	0.234	-0.477	4.13E-07	ABL1,AK2,AKR1B1,ATF3,ATF4,BCL2L1,BIRC3,CAT,CCL2,CCND2,CCND3,CDK4,CDKN1C,CFB,CTGF,CTSB,CXCL2,CXCL8,CYP2C8,DDIT3,DIABLO,DUSP1,EIF4EBP1,EPAS1,ESR1,ETS1,FGF2,FOS,G0S2,GNAI1,HIF1A,HMOX1,HSPA4,HSPA5,HSPA8,HSPA9,IER3,IL6,IRS2,ITPR2,JUN,MCL1,MMP2,MMP9,MRTO4,MYC,MYCN,NCF2,NFKBIA,NOX4,NQO1,PDCD4,PEBP1,PFN1,PIN1,PSMA3,PSMB2,PTGFR,PTGS2,RANGAP1,RPLP0,SCRIB,SLC27A1,SQSTM1,TIMP1,TJP1,TNFRSF10B,TNK2,TXN,VCAM1,WAS	Akt,Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TNF,TP53,benzyloxycarbonyl-Leu-Leu-Leu aldehyde	
P1	 	NFYA	0.113	transcription regulator	 	1.299	bias	0.368	-0.293	4.21E-07	ACLY,CAT,CBS/CBSL,CHEK2,COL11A1,COL1A2,COL5A3,EGR1,ELANE,EPHX1,F8,FTH1,GADD45A,GADD45B,GPAM,HSPA5,JUN,JUNB,LPIN1,NOTCH1,PADI4,PIDD1,PKM,PPP1R15A,PTTG1,RHOB,TGFBR2,THOP1,THRSP	Ap1,CREB1,ESR1,Histone h3,JUN,JUNB,NFYA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1	
P1	 	ursolic acid	 	chemical drug	Inhibited	-2.361	 	-0.215	-1.495	4.42E-07	AKR1B1,ATF3,BCL2L1,CD69,CXCR4,EIF2S2,EIF3C,EIF4EBP1,FGF2,FOS,GDF15,LARS,LEP,MARS,MMP2,MMP9,NARS,PDCD4,PTGS2,SARS,SLC6A9,TNFRSF10B,VCAM1	Ap1,CREB1,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,ursolic acid	
P1	 	PP1	 	chemical - kinase inhibitor	 	-1.190	bias	-0.285	-0.030	4.53E-07	ANGPT1,BCL2L1,CCND2,CXCL16,CXCL8,CXCR4,ERBB2,ESR1,FOS,HMOX1,JUN,MMP2,MYC,ODC1,PTGS2,SRC,TJP1,VCAM1	Akt,CREB1,CTNNB1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PIK3R1,PP1,RELA,Ras,SP1,SRC,STAT1,STAT3,TP53	
P1	 	FGF1	0.213	growth factor	 	0.614	 	-0.076	1.032	4.60E-07	ACTA1,AKR1B1,AKR1B10,APOE,AXIN2,CCL3,CTGF,CYR61,EDN1,EGR1,FOS,FRMD3,FZD2,FZD7,GCLM,GSTM1,GSTM5,HMOX1,JUN,MYC,NDNF,NOTCH1,NQO1,NR4A2,ODC1,PMEPA1,PTGS2,RHOU,SELE,SLC7A2,SPP1,TGM2,THBS1,TNFRSF12A,VCAM1,VEGFC	APOE,CTNNB1,ERK,FGF1,FGF2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SMAD3,SP1,STAT1,STAT3,TNF,TP53	
P1	 	lactacystin	 	chemical - protease inhibitor	Activated	2.680	 	0.196	1.339	4.78E-07	ADRB2,AK2,AKR1B1,APOB,ASNS,ATF3,CCL2,CCND2,CCND3,CD24,CD69,CTSD,CXCL8,CXCR4,CYB5A,DDIT3,DUSP1,EBNA1BP2,ESR1,FBP1,GNAI1,HIF1A,HMOX1,HSPA5,IFRD1,IL6,IRS2,LDLR,MAP1B,MMP2,MMP9,MRTO4,MYCN,NEDD9,NFKBIA,P4HA2,PEA15,PEBP1,PFN1,PIN1,PRKCE,PTGS2,RANGAP1,RPLP0,SLC3A2,SQSTM1,TUBB2A,TXN,TXNRD1,VAV3,VHL,ZFP36L2	AKT1,APP,Akt,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53,lactacystin	
P1	 	SMAD3	0.251	transcription regulator	 	0.189	bias	0.257	-1.455	4.81E-07	ADORA1,APOB,BMP2,BMP6,CCL2,CCL3L3,CCND2,CCNG2,CDH2,CDH5,CDK4,CDKN2B,COL1A1,COL1A2,COL3A1,COL6A1,COL6A3,COL7A1,CTGF,CYP11A1,EDN1,EGR1,ELN,ESR1,FNDC5,FOS,FST,GADD45B,HBEGF,HEY1,HMOX1,HP,ID1,ID3,IL6,JUN,JUNB,LPAR1,LUM,MMP9,MYC,NET1,PMEPA1,POR,PTGS2,RHOB,S1PR1,SMAD7,SPP1,TAGLN,TF,THBS1,TIMP1,TPM1,TPSAB1/TPSB2,VEGFC,ZFP36	Ap1,CTNNB1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TGFB1,TP53,Tgf beta	
P1	 	cyclosporin A	 	biologic drug	 	0.316	 	-0.152	1.744	4.89E-07	ADORA1,AGT,AKR1B1,ANG,APOB,APOE,ASNS,ATF3,BCL2L1,BIRC3,BMP2,CADM3,CAPN6,CARD8,CAV1,CCL2,CCL3L1,CD14,CD163,CD55,CD68,CD86,CDK4,COL1A1,CSTF2,CTGF,CXCL8,CXCR4,CYBA,CYP27A1,DDIT4,DEXI,EDN1,EDNRA,EFEMP2,EGR1,EGR2,EIF6,EMP3,FCER2,FLNA,FOS,FST,FYN,GNPDA1,GPNMB,GSTM3,HIF1A,HMOX1,HS2ST1,HSPA5,ID3,IER3,IL6,ITPR2,JUN,KCNK3,KDR,LDLR,LXN,LYN,LYVE1,MAF,MIF,MMP2,MMP9,MYC,MYH11,NFKBIA,NME1,ODC1,PA2G4,PDCD4,PDE3B,PERP,PKM,PSMB10,PTGS2,RCAN1,RUNX1,S100A9,SDCBP,SELE,SERPINH1,SIAH2,SPP1,TAGLN,THOP1,TIMP1,TNFRSF12A,TNFSF10,TUBB,UPP1,VCAM1,VPS4B,XAF1	HIF1A,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TNF,TP53,cyclosporin A,doxorubicin	
P1	 	5-N-ethylcarboxamido adenosine	 	chemical reagent	 	0.620	 	-0.024	0.757	4.93E-07	ADM,ARG2,BTG2,CCL2,CCL3L3,CDKN2B,CEBPD,CES1,COL1A2,CTGF,CXCL8,EGR1,EGR2,FGF2,GADD45A,HIF1A,HMOX1,IER2,IFIT2,IL6,JUNB,KLF6,NR4A2,NR4A3,NRP1,ODC1,PROCR,SLC4A7,SOCS3,SOX17,SRXN1,THBD,THBS1,VCAN	5-N-ethylcarboxamido adenosine,Akt,CEBPB,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	HMOX1	1.058	enzyme	 	1.066	 	-0.033	1.242	4.93E-07	ABCG1,ADIPOQ,ANGPT1,BCL2L1,CCL2,CD14,COL1A1,CS,CXCL12,CXCL2,CXCL8,FOS,G6PD,HMOX1,ID1,ID3,IL6,ITGAM,KDR,MMP9,NQO1,NR4A2,PROCR,PTGS2,RELN,SELE,SPARC,TEK,THBD,THBS1,TYMP,VCAM1,VEGFD,ZFP36	Ap1,EP300,ERK,HMOX1,JUN,Jnk,NADPH oxidase,NFKBIA,NFkB (complex),P38 MAPK,PPARG,PTGS2,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	ADCYAP1	0.373	other	 	1.080	 	0.120	0.191	4.95E-07	ACAT1,ACTN1,ANGPT1,AZIN1,BMP6,BTG2,CCL3L3,CD86,CEBPD,COL3A1,COL5A1,COL5A2,CXCL2,EGR1,EGR2,EGR3,ENPP2,FOS,FST,GAP43,GCLM,GPC3,GRK5,H2AFZ,HK1,ID3,IER3,IL6,IRF3,ITGAM,KRT8,LUM,MAPK8IP3,MCAM,MCM2,MME,MYC,NECAP2,NFKBIA,NPR3,NPY5R,NQO1,ORM1,POMC,POR,PSMB7,RAB3IP,RGCC,RHOB,SCAMP3,SERPINA3,SERPINE2,SLC1A3,SOCS3,SPARC,TSC22D1,TTYH1,TUBB2B,TXNRD1,UCP2	ADCYAP1,CEBPA,CEBPB,ERK,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TNF,TP53	
P1	 	lysophosphatidic acid	 	chemical - other	Inhibited	-2.431	bias	0.360	-4.291	5.02E-07	CCL2,CD36,CTGF,CXCL2,CXCL8,CYR61,DUSP1,EDN1,EGR1,FOS,GRN,HIF1A,HYOU1,IL6,ITGAM,JUN,JUNB,KDR,LIPE,LIPG,MMP9,MYC,PFKFB1,PLAUR,PTGS2,RALA,S1PR3,TAGLN,TF,VEGFC	CREB1,ERK,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,STAT3,TNF,lysophosphatidic acid	
P1	 	AG490	 	chemical - kinase inhibitor	 	0.592	bias	-0.389	2.592	5.64E-07	ACAT1,AGT,AKR1C3,BCL2L1,BIRC3,CCL2,CCND3,CD24,CD68,CXCL8,EDN1,ESR1,FGF2,FOS,IL6,LY96,MCL1,MMP9,MYC,MYH11,PLA2G2A,PTGS2,PTTG1,SAA1,SOCS3,SPP1,TAGLN,TIMP1,TNFSF10	AG490,CEBPA,CEBPB,ERK1/2,GSK3B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	ST3-Hel2A-2	 	chemical reagent	 	-1.666	bias	0.501	 	6.10E-07	ATF3,CDKN1C,DDIT3,EGR2,FOS,GADD45A,IER3,NR4A2,PHLDA1	CEBPA,CEBPB,DDIT3,EGR2,JUN,NFAT (complex),NFkB (complex),RELA,ST3-Hel2A-2,STAT1,STAT3,TP53	
P1	 	PDX1	-0.059	transcription regulator	Inhibited	-2.669	 	0.092	-3.221	6.15E-07	AKR1B1,ARRDC4,ATF3,ATG9A,ATP2A2,CAT,CDO1,COL1A1,COL3A1,CSNK2B,CXCL2,CXCR4,DUSP5,EGR1,FGF2,GAP43,GCLM,GOT1,GRN,GUSB,HK1,ID1,ID3,IDH1,IER3,IGFBP3,IL6,IRS2,JUN,JUNB,KLF6,KRT8,LXN,MYC,NDUFB9,NPTX2,NQO1,NR5A2,NUPR1,PC,PNPO,PPP1R1A,PRSS23,PTPRF,SLIT3,SPP1,TGFBR3,TIPRL	CEBPA,CEBPB,CREBBP,EP300,FOS,FOXO1,FOXO3,Growth hormone,HIF1A,INS,Ins1,Insulin,NFkB (complex),PDX1,PPARA,PPARG,RELA,RNA polymerase II,SP1,TP53	
P1	 	NCOR1	0.049	transcription regulator	 	0.966	bias	-0.301	1.848	6.30E-07	ADIPOQ,COX8A,CSF3R,DDT,DHCR24,DUSP1,IGFBP3,LYZ,ME1,MME,MMP9,MRPS18B,MT1X,NDRG1,NDUFV1,NR1D1,PDK4,PLA2G2A,PLIN1,PMEPA1,PRKCD,PTGS2,RARA,SCAP,SORD,STK39,THRSP,WARS2	AR,Ap1,ESR1,FOS,FOXO1,HDAC3,JUN,NCOR1,NCOR2,NFkB (complex),NR3C1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SMAD3,SP1,SREBF1,STAT3,THRB,TP53,mifepristone	
P1	 	amino acids	 	chemical - endogenous mammalian	 	0.337	 	-0.150	0.843	6.42E-07	ASNS,DDIT3,FOS,FOSB,GAPDH,HIF1A,IL6,JUN,JUNB,ODC1,SELE,SLC7A1,SLC7A2,THOP1	ATF2,CEBPB,ELK1,FOS,FOXO1,Growth hormone,HIF1A,IGF1,Insulin,JUN,MAPK3,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,SP1,STAT3,amino acids	
P1	 	E. coli serotype 0127B8 lipopolysaccharide	 	chemical - endogenous non-mammalian	 	0.024	 	0.154	-1.057	7.10E-07	ADGRG2,ADIPOQ,ADORA1,ADRA2A,AQP11,AQP9,CAV1,CCL2,CD14,CTGF,CXCL12,CXCL16,CXCL2,CXCR4,DDIT3,EDEM1,EDNRA,EGR2,ELN,FAM107A,FGF2,FZD2,GJB2,GLUL,GNG2,GPR146,HCAR2,HMOX1,HSPA5,IL17D,IL6,IRF3,ITPK1,KLF2,LOX,MAP3K8,NFKBIA,NGF,PCK2,PPP1R1B,PRDX5,PTGS2,S1PR3,SLC4A2,SLC52A2,SLC7A5,SOCS3,SYNM,TGFBR2,TGFBR3	Ap1,E. coli serotype 0127B8 lipopolysaccharide,IFNG,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF	
P1	 	MEOX2	-0.658	transcription regulator	 	1.767	bias	-0.347	3.224	7.35E-07	ANGPT1,CCL2,CD69,CDKN1C,CXCL2,CXCL8,EDN1,FGF2,HBEGF,ID1,ID3,ID4,IL6,PTX3,SELE,TNFAIP3,VCAM1,VEGFC	JUN,MEOX2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P1	 	TGFB3	-0.039	growth factor	 	-0.513	bias	0.379	-2.538	7.37E-07	ACTA1,ACTG2,CD59,CDH2,CDKN2B,COL11A1,COL1A1,COL1A2,COL3A1,COL5A1,CYR61,ELN,ETS1,FGF2,FOS,FOSB,JUN,LTBP2,MGP,MMP2,MMP9,MYO10,PLAUR,SERPINE2,SH3PXD2A,SMAD7,TAGLN,TGFBR3,THBS1,TJP1,TNS1,TPM1,TSPAN13	Ap1,ERK1/2,FGF2,FOS,HRAS,JUN,MAPK8,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TGFB3,TP53	
P1	 	simvastatin	 	chemical drug	 	0.117	 	-0.114	0.790	7.74E-07	ABCG1,ACP5,ADRB2,ANXA3,APOB,ARHGDIA,ARHGEF2,ATP13A1,BCL2L1,BMP2,C12orf10,C5AR1,CCL2,CCL3,CCND2,CD14,CD55,CTGF,CXCL2,CXCL8,CYR61,EDN1,ESR1,FOS,HIST1H1C,HK1,HMOX1,IGFBP3,IL6,KIT,KLF2,LDLR,MMP2,MMP9,MYC,NCF2,NFIX,NFKBIA,PLAT,PTGS2,RHOB,RHOU,S1PR3,SDC4,SELE,SOCS3,SPP1,ST6GALNAC4,THBD,TIMM10,TIMP1,TNFRSF10B,VCAM1	Ap1,ERK1/2,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,simvastatin	
P1	 	MAPK3	0.231	kinase	 	-1.193	bias	0.380	-2.945	8.22E-07	BMP4,CCL3,CD69,CDKN2B,CSTA,CXCL8,EGR1,ESR1,FOS,FOSB,HDC,IL6,JUN,JUNB,MCL1,MMP9,MYC,PLA2G4A,PLAUR,PTGS2,SLC4A7,SPP1,THBS1,TIMP1,TNFRSF10B	CEBPB,ELK1,ERK,ERK1/2,FOS,HDAC2,Hdac,JUN,MAP2K1,MAPK1,MAPK3,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SRF,STAT1,STAT3	
P1	 	GNA15	0.555	enzyme	 	 	 	 	 	8.57E-07	AKAP12,CASP4,CD69,CDO1,CEBPD,CXCL2,CXCL8,DAB2,DDIT3,FHL1,FMO1,GADD45A,GLUL,HMOX1,IL6,LBP,MYC,MYH1,MYH11,NOX4,NPR3,ODC1,PAWR,PLAT,SERPINA3,SLC7A1,TAGLN,THBD,TIMP1,TRIB3,UNC5B,VCAN	Ap1,CEBPA,CEBPB,GNA15,HRAS,IKBKB,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TP53	
P1	 	INHBA	0.047	growth factor	 	-0.123	bias	0.265	-1.864	8.66E-07	ACTN1,ADRB2,AKR1C3,BAMBI,BCL2L1,BMP2,CCL2,CCND2,CD24,CDK4,CDKN2B,CHD7,CTGF,CXCL8,CXCR4,CYP11A1,DTNA,EFNB2,ESR1,ETS2,F13A1,FOLR2,FST,GULP1,HLA-G,IL6,INHBB,JUNB,KLF4,LHCGR,LOX,MAF,MCL1,MGP,MMP2,NR4A2,PCDH9,PCSK5,POMC,RGS16,S100A8,S100A9,SMAD6,SMAD7,SOX17,TAGLN,TIMP1,TPSAB1/TPSB2,VAV3	CREB1,Cg,ERK1/2,FOS,FSH,IL1B,INHBA,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad	
P1	 	POR	0.888	enzyme	 	-1.270	 	-0.196	-0.321	8.66E-07	ABCC3,ACADVL,ACAT2,ACLY,ACTA1,ALDH1A1,ALDH1A2,ANXA5,APCDD1,ASNS,ATF5,C11orf54,CD36,CPA3,CSAD,CYP2C8,CYP51A1,DHCR24,DHCR7,ECI1,ELOVL3,ELOVL6,FOXC1,GADD45B,GSTM1,GSTM5,HIF1A,HMGCS1,HMOX1,HSD17B11,KDR,LDLR,LSS,MSMO1,MVD,PDK4,PFKFB3,PGD,POR,PRNP,SDC4,SERPINA3,SLC22A5,SQLE,SUSD2,TM7SF2,TMEM267,TMEM97,TUBB2B	NFE2L2,POR,VHL,iron	
P1	 	mibolerone	 	chemical drug	Activated	3.928	 	0.160	2.951	8.77E-07	ABCA8,AHNAK,ALCAM,ALDH3A1,BMP6,CCDC80,CLTB,COL1A1,COL1A2,COL6A3,CYP51A1,DHRS3,DNAJB11,ERP29,FHL1,FKBP1A,GOT2,GPC3,GPNMB,HMGCS1,HSD17B11,HSPA5,HYOU1,IGFBP3,JUN,LDLR,LSS,MME,MYC,NME1,PRELP,S100P,SCAP,SLC22A5,SMPDL3A,SQLE,SRM,TF,TMED3,UCP2	AR,NCOR1,NR3C1,SP1,STAT3,TP53,mibolerone	
P1	 	estrogen	 	chemical drug	 	1.728	bias	0.333	-0.585	9.25E-07	AGT,ALDH1B1,AP3D1,APOB,APOE,AXL,BMP2,CCL2,COL15A1,COL18A1,COL1A1,COL3A1,COL5A1,COL6A2,CRABP1,CTGF,CTSD,CXCL12,CYP11A1,CYR61,DLG4,DUSP1,EGR1,EPAS1,ERBB2,ESR1,FOS,FTH1,G6PD,GALK1,GAP43,GJB2,HBEGF,HIF1A,IDO1,IGFBP4,IGFBP6,IL6,ITM2A,JUN,JUNB,KDR,LDLR,LIG1,MEOX2,MVD,MYC,NME1,PLAT,POLD1,PPRC1,PTGDS,PTGS2,PTTG1,PTX3,RARA,RET,S1PR1,SERPINA3,SERPINE2,SFTPD,SLC2A8,SPARC,SPP1,SRM,UNG,ZFP36	Ap1,EGF,FOS,IL1B,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TP53,estrogen	
P1	 	PRDM1	-0.267	transcription regulator	 	0.698	 	-0.120	1.567	9.50E-07	ADGRG1,ALPL,ANGPTL4,APOBEC3C,ARG2,ATG7,AXIN2,BTK,CADPS2,CD86,CPA4,CRISPLD2,CXCL2,CXCR4,DBNDD1,DDIT4,EGR2,ESR1,FAR2,FCER2,FNDC5,FOS,FTH1,FZD2,GBE1,HIST2H2AA3/HIST2H2AA4,ID3,IL18RAP,IL6,IRF2BP2,JCHAIN,MCL1,ME1,MMP25,MS4A4A,MSC,MT2A,MYC,NLRP3,PLA2G4A,PSMB10,RARRES3,RELN,S100A8,S100A9,SCARA5,SERPINA3,SLC16A5,SLC2A5,SLCO2B1,SRD5A1,SWAP70,TNFSF10,TRIB1,TRPM8,TSPAN10	Ap1,CEBPA,CEBPB,CSF3,ESR1,Histone h3,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),PRDM1,RELA,RNA polymerase II,SP1,STAT1,STAT3,STAT6,TNF	
P1	 	IKBKG	0.602	kinase	 	0.712	bias	0.382	-1.494	9.78E-07	ACTA1,AEBP1,ATP2A2,BMP2,CCR1,CEBPD,CH25H,CTSB,CXCL12,CXCL2,CXCL8,ENPP2,FCER2,FOS,GM2A,GRN,IGFBP6,IL6,JUNB,KCND2,MGP,NAGLU,NGF,OGN,PCDH7,PLD3,PTX3,RCAN1,RGS16,SEMA3C,SERPINE2,SFRP1,SGK1,SLC16A2,SOCS3,TNFAIP3,TNFSF10	Ap1,CHUK,IKBKB,IKBKG,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P1	 	Growth hormone	 	group	Inhibited	-2.035	bias	0.251	-3.507	1.02E-06	ADIPOQ,ADRB2,ANGPTL4,BMP4,CCND2,CD36,CEBPD,COL1A1,EGR1,FOS,FZD5,FZD7,G6PD,GDF15,GSTM1,GSTM5,IER3,IGFBP3,IGFBP6,LDLR,LEPR,LIPE,MMP9,MYC,NEDD9,NFKBIA,NOX4,NR1D1,PDK4,PFKFB3,PIK3C2B,PPP1R15A,SGK1,SOCS2,SOCS3,SPP1,TGFBR2,TNFSF10	CEBPB,ERK1/2,FOXO1,Growth hormone,HIF1A,IGF1,IL1B,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,SP1,STAT3,TNF	
P1	 	GnRH-A	 	chemical reagent	Inhibited	-3.322	 	0.111	-3.882	1.04E-06	AKR1B10,ANXA5,ATF3,BTG2,CD68,CIDEA,EGR1,EGR2,EIF2AK1,FOS,FOSB,FST,GADD45B,IER2,JUN,JUNB,KLF4,KLF6,NFKBIZ,PPP1R15A,PRSS23,PTGDS,RASD1,SPPL2B,TMBIM1,ZFP36	Ap1,ELK1,ERK,FOS,GnRH-A,JUN,MAPK1,MAPK3,MAPK9,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	corticosterone	 	chemical - endogenous mammalian	 	-1.309	 	0.020	-1.417	1.10E-06	ACACA,APOB,ATP2B1,CAV1,CDK4,CLDN5,CTGF,CYBA,CYP11A1,DDIT3,DDIT4,EDN1,FGF2,FOS,GLUL,GPAM,H19,HSPA5,IL6,JUN,KLF9,LEP,LIPE,MAOA,MMP9,MTOR,MYC,NOX4,PDK4,POMC,PTGS2,RELN,SFRP1,SGK1,UCP2	Ap1,CREB1,EP300,ERK1/2,JUN,LEP,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,POMC,PPARG,RELA,RNA polymerase II,SMAD3,STAT1,STAT3,corticosterone	
P1	 	3,4,5,3',4'-pentachlorobiphenyl	 	chemical toxicant	 	-0.869	 	0.222	-1.969	1.13E-06	BMP4,CA3,CAT,CCND2,CES1,CLDN5,COL1A1,COMT,CYB5A,CYP1B1,CYP2C8,EPB41L3,ESR1,ETS2,GADD45A,HSPA1A/HSPA1B,HSPA2,IDH1,IGFBP3,ITGA7,JUN,MYH11,NOTCH1,NQO1,PTGFR,SLCO2B1,SOCS2,TIPARP	3,4,5,3',4'-pentachlorobiphenyl,9,10-dimethyl-1,2-benzanthracene,AHR,AR,Ap1,CEBPB,Creb,ESR1,ESR2,FOS,JUN,NFKB2,NFkB (complex),PGR,RELA,SP1,STAT1,STAT3,TP53,progesterone,testosterone	
P1	 	homocysteine	 	chemical - endogenous mammalian	 	0.324	 	0.233	-0.734	1.13E-06	ATF3,ATF4,ATF6,BCL2L1,CCL2,CLDN5,CXCL12,CXCL8,DDAH2,DDIT3,FGF2,GADD45A,HCAR2,HMOX1,HSPA5,ID1,IL6,ITGAM,LEP,MMP2,NDRG1,PHLDA1,PTGS2,SAA1,SOCS3,TIMP1,TRIB3,VCAM1	Ap1,CEBPA,CEBPB,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SREBF2,STAT1,STAT3,TP53,cholesterol,homocysteine	
P1	 	BMP6	-1.600	growth factor	 	-0.238	bias	0.251	-1.381	1.14E-06	ACADM,ADAMTS1,ALDH1A2,BMP4,CDKN2C,CTGF,CYP11A1,CYP1B1,EPHX1,ETV5,HBEGF,HMOX1,ID1,ID3,IL6,KLF4,MATN2,MYCN,PCOLCE2,PMEPA1,PMP22,PTGS2,SDPR,SLC20A1,SORD,TAGLN,TEF,TIMP1,TNFRSF12A,TXNRD1	BMP6,IL6,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,RUNX2,SMAD1,SMAD3,SMAD4,SMAD5,SP1,STAT1,STAT3,Smad	
P1	 	Akt	 	group	 	-0.557	 	0.216	-2.050	1.18E-06	ADM,ANGPT1,ATF4,ATG7,BCL2L1,BMF,BMP2,CCL2,CCND2,CCND3,CD36,CDK4,CDKN1C,CIDEA,COL3A1,CTGF,CTSD,CXCL12,CXCL8,CXCR4,EGR2,ELK1,EPAS1,ESR1,ETS1,FOS,GSK3B,HIF1A,HMOX1,IER3,IL6,JUN,LEP,LHCGR,LMNA,MCAM,MCL1,MMP2,MMP9,MYC,NDRG1,NDUFV1,NOTCH1,NOX4,PDK4,PEA15,PPP1R1B,PTGER4,PTGS2,PTX3,RHOB,SLC4A7,SOCS3,SPP1,THBS1,TJP1,VCAM1,VCAN	AKT1,Akt,Ap1,ERK,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	MAPK1	0.464	kinase	 	0.813	 	-0.019	0.961	1.27E-06	ADAM17,ADH1C,APBB3,APOE,ARG2,ATF3,ATP1A2,CAPN2,CAV1,CCL2,CCL3L3,CD69,CDH2,CFB,COL7A1,COX17,CRABP2,CRYL1,CSTA,CTGF,CTSB,CXCL8,DAB2,DDT,DUSP1,EGR1,EGR2,EMP1,ERCC1,ERP29,ESR1,FLNC,FOS,FOSB,GBP1,GNG2,HDC,HMOX1,IFI27,IFIT2,IL6,ISG20,ITPR2,JUN,JUNB,LAMP3,LIG1,LMNA,MAP3K20,MBP,MCL1,MMP2,MMP28,MMP9,MNS1,NRP1,NUPR1,OLFML2A,PLA2G4A,PLA2G5,PSME2,PTGS2,PTPRK,RGS16,SFRP2,SLC4A7,SOCS2,SP110,SPP1,SPRY2,TJP1,TMEM158,TNFRSF10B,TNFSF10,TRIM5,UBE2I,ZFP42	CEBPA,CEBPB,EGR1,ELK1,FOS,JUN,MAP2K1,MAPK1,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	TFAP2C	-0.069	transcription regulator	 	0.402	 	-0.135	0.946	1.29E-06	ALCAM,CTGF,CYP11A1,EGR3,ERBB2,ESR1,FKBP4,FOXC1,FST,GZMH,HIST1H1C,HK1,KRT8,MBP,MYC,NRP1,RARA,RET,SEMA3B,SFTPD,SLC19A1,THBS1,TNFAIP3	 	
P1	 	poly rI:rC-RNA	 	biologic drug	Inhibited	-3.034	bias	0.373	-6.315	1.31E-06	ACSL3,AFAP1,ATF3,ATF4,ATP6V0A2,AXL,BIRC3,C2,CCL2,CCL3,CCL3L1,CCL3L3,CCL8,CCND3,CD14,CD209,CD36,CD69,CD86,CDH2,CEBPD,CFB,CHN1,CXCL2,CXCL8,CXCR4,DEFB1,DUSP1,DUSP5,EDN1,EGR1,FGF2,FOS,GADD45B,GBP1,GDF15,HLA-F,HLA-G,IDO1,IFI27,IFIT2,IGFBP6,IL10RA,IL6,IRAK1,IRF3,ISG20,ITGAM,JUN,JUNB,KLF4,KLF6,LIPG,LY6E,LYN,LYZ,MARCO,MMP2,MMP9,MYC,NFKBIA,NLRP3,NOTCH1,NR4A2,NR4A3,PCK2,PHLDA1,PI4KB,PLAUR,PPP1R15A,PRKCD,PSMA3,PSME2,PTGS2,PTPN23,RARRES3,RGS1,SDC4,SELE,SFTPD,SRGN,STAB1,TFPI2,THBS1,TIPARP,TNFAIP3,TNFRSF10B,TNFSF10,TPO,VCAM1,ZFP36,ZFP42	HIF1A,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,poly rI:rC-RNA	
P1	 	IRAK4	-0.154	kinase	 	-0.498	bias	0.279	-1.206	1.41E-06	ATF3,BIRC3,BTG2,CD86,CSRNP1,CXCL16,CXCL2,CXCL8,DAB2,EDN1,EGR1,FOS,FOSB,IER2,IFRD1,IL6,IRF3,JUN,MAP3K8,MARCO,NFKBIA,NFKBIZ,PHLDA1,RGS16,TNFAIP3,ZFP36	Ap1,HIF1A,IRAK4,JUN,MAPK9,MYD88,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF	
P1	 	CD3	 	complex	 	-0.439	bias	-0.338	2.869	1.46E-06	AARS,ACTG2,AHCYL1,ANG,AP1B1,ATF4,BAMBI,BCL2L1,BIRC3,BTG1,C1R,C2,CCL18,CCL3,CCL3L1,CCL3L3,CCND2,CCND3,CCR1,CD4,CD69,CD86,CDK4,CH25H,CLIP1,CS,CSTF2,CXCL8,CXCR4,CYBA,CYC1,DDT,DHRS4,DUSP14,DUSP22,EGR2,EGR3,ETS1,ETS2,FBL,FCER1G,FKBP1A,FKBP2,FMO3,FOS,FYN,G6PD,GAPDH,GBP1,GTF2IRD1,GYS1,H19,HAX1,HGS,HIF1A,HINT1,HIST2H2AA3/HIST2H2AA4,HOMER2,HS2ST1,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPE1,ID3,ID4,IGFBP6,IL6,JUN,JUNB,KCNK3,LONP1,LSP1,LYN,MAF,MAP3K8,MMP2,MST1,MT1G,MTHFD2,MYC,NCL,NFKBIA,NFX1,NME1,NPIPA8 (includes others),ODC1,OGN,PA2G4,PCBP2,PCSK7,PCYT2,PFN1,PLEC,PLIN2,POMZP3,PTGER4,PTGS2,RBBP8,RPL6,SCO1,SHC1,SMO,SNRPB,SOCS2,SOCS3,SORL1,SOS1,SRGN,SRPRB,STIM1,STOM,STX6,TCEA1,TFPI2,TFRC,TGM2,THBS1,THY1,TNFAIP3,TNFRSF4,TNFSF10,TRIM5,TSTA3,TXNRD1,VPS4B,XAF1,YARS,ZFP36	Ap1,CD3,CREB1,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PI3K (complex),RELA,SP1,STAT1,STAT3,TCR,TNF	
P1	 	IL2	-0.082	cytokine	 	-0.513	bias	0.311	-2.991	1.58E-06	ABCC1,ARHGDIA,ATF5,BCL2L1,BIRC3,BMP2,CAPN5,CARD9,CCL2,CCL3,CCL3L1,CCL3L3,CCND2,CCND3,CCNG2,CD59,CD69,CD86,CDK4,CDKN1C,CDKN2C,CMKLR1,CSF1R,CSF2RA,CSRNP1,CTPS1,CXCL12,CXCL8,CXCR4,CYP27A1,CYTIP,DAPK2,DKC1,DUSP5,EDN1,EEF1E1,EMP1,ENPP2,ETS1,FCER1G,FCGR3A/FCGR3B,FGF2,FOS,FYN,GADD45B,GAPDH,GARS,GDF15,GNL3,HAVCR2,HCST,HSPA1A/HSPA1B,HSPA5,IDO1,IER3,IL10RA,IL18RAP,IL6,ISG20,ITGA1,JUN,KIT,KLF6,LDLR,LY6E,MAF,MAP3K20,MAPKAPK2,MMD,MME,MMP2,MMP25,MMP9,MYC,NME1,NOP2,PDCD4,PDE3B,PEA15,PHLDA1,PHLDA2,POLR1C,PTGS2,PUS1,RGCC,RGS16,RHOB,RRAS2,RUFY1,SLC2A3,SOCS2,SOCS3,SOS1,SPP1,STIP1,TIMP1,TNFAIP8,TNFRSF10B,TNFRSF12A,TNFRSF21,TNFRSF4,TNFSF10,TRIB3,UPP1,YARS	Ap1,IL18,IL1B,IL2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF	
P1	 	SNAI1	0.066	transcription regulator	 	0.897	 	-0.096	1.275	1.65E-06	ACTN1,ACTR1A,ADIPOQ,AFAP1,BCL2L1,CCL2,CCND2,CCND3,CD55,CDH2,CDH5,CDK4,COL1A1,CXCL8,ERCC1,FLNA,FLNC,FOS,ID1,LIMA1,MMP9,MYO5A,PARVB,PEBP1,PTGS2,SPARC,THBD,TMOD1,TPM1,WAS,WASF3	Akt,Ap1,CTNNB1,EGR1,ESR1,EZH2,HDAC1,HDAC2,HIF1A,Hdac,Histone h4,JUN,NFkB (complex),RELA,SIN3A,SMAD3,SNAI1,SP1,STAT3,TCF,TP53	
P1	 	cigarette smoke	 	chemical toxicant	 	-0.353	bias	0.384	-2.377	1.67E-06	ADM,AKR1B10,ALDH3A1,AOX1,ATF4,ATF6,BCL2L1,CAT,CCL2,CCL3L3,CCT5,CXCL2,CXCL8,CYP1B1,CYR61,DDIT3,DNAJB2,EGR1,ELN,EPAS1,FOS,G6PD,GCLM,GPX3,GSR,GSTM5,H19,HIF1A,HMOX1,HSPA5,HSPA9,IL6,JUN,KDR,KLF4,LEP,MMP2,MMP9,NOX4,NQO1,P2RX4,P2RX7,PGD,PTGS2,PTPRB,RAMP2,SERPINA3,SLC1A4,SLC6A9,SMAD7,SOCS2,SQSTM1,TIMP1,TXNRD1	Akt,BACH1,CREB1,ERK1/2,FOS,HIF1A,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,STAT3,TNF,TP53,cigarette smoke	
P1	 	tetrachlorodibenzodioxin	 	chemical toxicant	 	-1.078	 	0.027	-1.254	1.74E-06	AARS,ABCB6,ACTN1,ADIPOR2,ADM,ALDH3A1,ANGPT1,ASNS,ATF4,ATP2B1,BMP4,BTG1,CA3,CBR3,CD36,CD86,CES1,CHD7,COL18A1,COL4A5,COL6A1,COMT,CTSD,CXCL8,CYP11A1,CYP1B1,CYP4B1,CYR61,EDN1,EIF4EBP2,ELN,EMP3,EPS15L1,ERBB2,ESR1,ETS2,FMO2,FMO3,FOS,FZD7,GHITM,HDAC11,HMOX1,HRAS,HSPA1A/HSPA1B,HSPA2,HSPA8,IDH1,IL10RA,IL6,ITGA7,JUN,KLF2,LHCGR,MARCO,MYC,MYH11,MYO10,NME1,NQO1,ODC1,PERP,PTGFR,PTGS2,S100A8,S100A9,S1PR1,SAA1,SERPINH1,SLC22A5,SLC2A3,SLC4A2,SLCO2B1,SNAPC2,SOCS2,SRC,STC2,TGFBR2,TIPARP,TNFRSF19,TXN,VEGFC	17-alpha-ethinylestradiol,AHR,CEBPA,CEBPB,EGF,ESR1,IL1B,JUN,MYC,N-cor,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD4,SP1,STAT3,TNF,TP53,tetrachlorodibenzodioxin	
P1	 	Salmonella enterica serotype abortus equi lipopolysaccharide	 	chemical toxicant	Inhibited	-2.922	bias	0.501	 	1.87E-06	ADRB2,ARRDC4,ASNS,BIRC3,BRE,CCL18,CCL3,CCL3L3,CDKN2B,CFB,CXCL2,DNAJB4,EDN1,EGR1,EGR3,ETS2,G0S2,GADD45A,GADD45B,GBP1,GJB2,HES4,HEY1,IDO1,IFIT2,IL6,KANK1,KCNJ2,LAMP3,MAP3K8,NEDD4L,NFKBIZ,NLRP3,NR4A2,OSGIN1,PHLDA1,PHLDA2,PTGS2,PTX3,RGS1,RHOU,SIAH2,SLC1A3,SOCS3,TFPI2,THBS1	Ap1,FOS,IL6,JUN,MAPK8,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,Salmonella enterica serotype abortus equi lipopolysaccharide,TNF	
P1	 	ionomycin	 	chemical reagent	 	-1.164	bias	0.371	-3.566	1.87E-06	AHNAK,BCL2L1,BMP2,BTK,CCL3,CCND2,CCNG2,CD276,CD4,CD69,CIDEC,CUL9,CXCL8,DUSP1,EGR1,EIF4EBP1,EIF4EBP2,ETS1,ETS2,FOS,FOSB,GBP4,HIF1A,HSPA4,HSPA5,IL6,ITM2A,ITPR2,KCNJ2,LDLR,MAF,MMP9,MYC,NCL,NGF,NR4A2,NRP1,PTGS2,PTPRK,RCAN1,SGK1,SLC3A2,SOCS2,SPP1,STC1,TNFSF10	Ap1,ERK1/2,IKBKB,IL1B,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SMAD3,STAT1,STAT3,ionomycin	
P1	 	isotretinoin	 	biologic drug	 	0.894	bias	0.346	-0.833	1.89E-06	ABCG1,ALDH1A3,BCL2L1,CCL2,CRABP2,CXCL8,CYP1B1,DEFB1,IGFBP3,IL6,MMP9,ODC1,PLA2G15,PSMB10,PTGIS,PTGS2,RARA,RARRES1,RARRES3,S100A9,S100P,SERPINA3,SLC12A8,TFRC,TNFSF10,VCAM1	ALB,ATF2,Akt,Ap1,CEBPB,EGF,EGFR,FOS,HIF1A,JUN,MYC,NFKB1,NFkB (complex),RARB,RELA,SMAD3,SP1,SQSTM1,STAT1,STAT3,TP53,isotretinoin	
P1	 	PDLIM2	0.088	other	 	0.365	 	-0.022	0.485	1.92E-06	C4orf19,CHPF,CRISPLD2,CXCL8,DNAJC15,ENPP2,FBP1,GNG2,GSTM1,GSTM2,HBEGF,IGFBP3,KIT,MECOM,MME,MPZL2,MYEOV,NAV1,NPR3,PHLDA1,PHLDA3,PPP1R14A,PRUNE2,RTN1,SCARA3,SPOCD1,SRGAP1,STC2,TAGLN,TNS1	 	
P1	 	SYVN1	0.184	transporter	Activated	2.960	bias	0.472	0.018	1.96E-06	ABCC3,ACP2,ACSL3,AES,ATP6AP1,AXL,CEP164,CRTAP,CSPG4,CTPS1,CYB561,CYP1B1,DAB2,DPYD,DUSP1,ERN1,FANCG,ITGA3,MCAM,MGRN1,MYOF,PFN1,PVR,RAB34,RPN2,SCARA3,SKIV2L,SLC1A5,SLC20A1,SLC2A3,SLC35B2,SLC3A2,SLC4A7,SLC7A2,SLC7A5,STOM,TARS,TFRC,USP5	 	
P1	 	RELA	-0.046	transcription regulator	Inhibited	-2.805	bias	0.346	-5.285	2.01E-06	AGT,ALCAM,AP1B1,APOE,BCL2L1,BEX2,BIRC3,BMP2,BNIP3L,BTG2,CARD8,CAV1,CBS/CBSL,CCL2,CCL3,CD14,CD59,CD69,CFB,COL1A1,COL1A2,CTGF,CTSB,CXCL2,CXCL8,CXCR4,DDIT3,DGCR6/LOC102724770,DUSP1,EDN1,EGR1,ELN,ERAP2,ERBB2,FCGRT,FGF2,FOS,FSCN1,GBP1,GDF15,GRK5,HIF1A,HMOX1,IER2,IER3,IL6,JUN,JUNB,KIT,LUM,LYN,MGMT,MIA,MIF,MMP9,MYC,NFKBIA,NOTCH1,PI4KA,PSMB10,PTGDS,PTGS2,PTX3,SAA1,SAA2,SBF1,SDC4,SELE,SERPINE2,SLC2A5,SMAD7,SOX9,STIM1,TFPI2,TGM2,TNFAIP3,TNFRSF10B,TNFRSF4,TNIP1,TPO,VCAM1,VHL,WASF3	IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	NOTCH1	-0.505	transcription regulator	 	-0.847	 	0.068	-1.321	2.05E-06	ANGPT1,BCL2L1,BIRC3,BMP2,C21orf33/LOC102724023,CCND2,CCND3,CD14,CD68,CDKN1C,CEBPD,COL1A1,COL1A2,CSF1R,CTGF,CTSG,CXCL8,CYR61,EFNB2,ELANE,ERBB2,FCER1G,FGF2,FOS,FOSB,GAA,GRN,HEY1,HEY2,HEYL,ID1,IGFBP3,IGFBP4,IL6,ITGAM,KRT8,LOX,LYVE1,MCAM,MMP2,MYC,MYLK,NOTCH1,PIN1,PRAG1,PTGDS,PTGS2,PTPRK,RHOU,S100A1,SPI1,SPP1,TAGLN,TEK,TGFBR2,TGFBR3	AKT1,Akt,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	IL1A	0.102	cytokine	 	-1.896	bias	0.330	-4.233	2.16E-06	ADAMTS1,ALDH1A1,ALDH1A3,ALDH3A2,ASIC1,BCL2L1,BIRC3,CCL2,CCL3,CCL8,CD86,CTSK,CXCL12,CXCL2,CXCL8,CYP11A1,CYR61,FGF2,FOS,FTH1,GBP1,HDC,HLA-DRB4,HMOX1,HSD11B2,IL6,IRAK1,JUN,KIT,LEP,LOX,MCAM,MMP2,MMP9,MT2A,MYC,NFKBIA,NFKBIZ,NGF,ORM1,PLA2G4A,POMC,PTGS2,PTX3,S100A8,S100A9,SAA1,SAA2,SELE,SERPINA3,SPARC,SPP1,TNFAIP3,VCAM1,VEGFC	Ap1,ESR1,FOS,IL1A,JUN,MYD88,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SP1,STAT3,TNF	
P1	 	SPP1	2.054	cytokine	Activated	3.766	bias	0.319	1.738	2.17E-06	ADIPOQ,ANGPT1,BCL2L1,CAPNS1,CCL18,CCL2,CCL3,CDC20,CDH2,COL1A1,COX7A2L,CXCL12,CXCL2,CXCL8,DHCR7,ERBB2,ETS2,FOS,FOXRED1,GCDH,HMOX1,HOMER2,IL6,ITGA3,LOX,MECR,MMP2,MMP9,MYC,NDUFA9,NDUFB9,NDUFS7,NDUFS8,NDUFV1,NOTCH1,PGD,PLOD1,POR,PTGS2,PTPMT1,SOX9,SPP1,TGFBR2,TIMP1,TM7SF2,TXNRD2,VAT1	Akt,Ap1,ERK1/2,ESR1,HIF1A,IL10,JUN,Jnk,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SPP1,STAT1,STAT3,TP53	
P1	 	BRD4	-0.053	kinase	 	1.923	bias	0.483	-0.055	2.23E-06	ALDH1B1,BCL2L1,CCND2,CCR1,CD4,CDKN2B,CXCL2,CXCR4,DMAP1,FOS,HMOX1,KAT2A,MCL1,MLF2,MTHFD1L,MTMR2,MYC,NAV1,NME1,NQO1,RNF125,SELE,SFXN4,SLC19A1,SLC7A2,SORD,SRM,STC2,TYRO3	BRD4,CDK9,EP300,IL6,NFkB (complex),RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53	
P1	 	EGR1	-3.667	transcription regulator	 	1.343	bias	0.366	-0.897	2.23E-06	ATF3,ATP2A2,CACNA1H,CAV1,CCL2,CCL3L3,CCND2,CCR1,CDC20,COL1A1,COL1A2,CXCL2,CXCL8,DLG4,EGR1,EGR2,EIF4EBP1,ELK1,FGF2,GADD45A,GADD45B,GDF15,HMOX1,ITGAM,JUN,JUNB,LDLR,LHCGR,LYZ,ME1,MMP9,MYC,NDRG1,PEG10,PTGS2,SGK1,SLC12A2,SLC4A2,SPP1,SQLE,SYN1,TGFBR2,THBS1,TIMP1,TNFSF10,VCAM1	Ap1,CEBPB,EGR1,ERK,ERK1/2,ESR1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TNF,TP53	
P1	 	actinomycin D	 	chemical drug	 	1.143	bias	-0.339	3.533	2.27E-06	ABCG1,ADM,AGT,ASS1,CAV1,CCL2,CD55,CDH2,COL1A2,CTGF,CXCL8,CYR61,DUSP1,EDN1,EPAS1,ETS1,FLNA,FOS,FTH1,GADD45A,GAPDH,GSTM5,GUCY1A3,HBEGF,HIF1A,HK1,HMOX1,IGFBP4,IL6,IRS2,ITPR2,JUN,MAOA,MCL1,MMP2,MYC,NGF,PERP,PFKFB3,PLAUR,PTGIS,PTGS2,PTX3,RRM2B,SELE,SLC20A1,SLC27A1,SMAD7,SOCS3,SPP1,TF,THRA,TNFRSF10B,VEGFC	ARNT,Ap1,HIF1A,IL1B,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT3,TNF,VHL,actinomycin D	
P1	 	resveratrol	 	chemical drug	 	0.633	 	-0.052	1.014	2.68E-06	ADAM17,ADIPOQ,ATF3,BCL2L1,BIRC3,BMP2,BSG,CCL2,CCL3,CCL3L3,CCND2,CD14,CD36,CD69,CDK4,CS,CSF1R,CTSK,CXCL2,CXCL8,CYP11A1,CYP1B1,DDIT3,EDN1,EGR1,ESR1,FOS,GDF15,GLB1,HDGF,HEY1,HEY2,HIF1A,HMOX1,HSPA5,IGFBP3,IL6,ITGA1,JUN,KDR,LDLR,LEP,LITAF,MCL1,MMP2,MMP9,MYC,NDUFA13,NFKBIA,NOTCH1,NQO1,PDCD4,PDK4,PLIN1,PPP1R15A,PSMB5,PTGS2,RAN,SESN2,SPP1,SQSTM1,TFRC,TNFRSF10B,TNMD,TNS1,VCAM1,ZNF91	Ap1,ERK1/2,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,resveratrol	
P1	 	2-deoxyglucose	 	chemical drug	 	0.452	 	0.077	0.116	2.69E-06	ACACA,ATF4,BCL2L1,BMF,DDIT3,DDIT4,FOS,GOT1,HIF1A,HSPA5,IL6,JUN,LEP,MCL1,MYC,MYCN,NLRX1,ODC1,POMC,PTGS2,SPP1,TNFRSF10B	2-deoxyglucose,AR,Akt,CEBPB,FOXO1,FOXO3,GSK3B,Growth hormone,HIF1A,IGF1,Insulin,JUN,NFKB1,NFkB (complex),NR3C1,NR3C2,PPARA,PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53,corticosterone	
P1	 	dexamethasone phosphate	 	chemical drug	 	-0.359	 	0.125	-0.810	2.70E-06	CXCR4,DDIT4,DUSP1,ID3,IL6,LYVE1,NFKBIA,PDK4,PLEKHF1,SGK1,SOX9,THBS1,TIPARP	EP300,JUN,NFkB (complex),NR3C1,RELA,STAT1,dexamethasone phosphate	
P1	 	DDIT3	2.344	transcription regulator	Activated	2.094	bias	0.305	0.806	2.83E-06	ATF3,ATF5,BHLHE22,CASP4,CEBPD,CLPP,CXCL8,DDIT3,HMOX1,HSPA5,HSPE1,IL6,ITGAM,PPP1R15A,SARS,SELE,TENM4,TNFRSF10B,TRIB3,WARS,XPOT	CEBPA,CEBPB,CREB1,Ca2+,DDIT3,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT3,TNF,TP53	
P1	 	cobalt chloride	 	chemical reagent	 	-1.783	bias	0.356	-3.524	2.84E-06	ADAMTS1,ADM,ALDOA,BHLHE41,COL18A1,CXCL8,CXCR4,DDIT4,DUSP1,EPAS1,HIF1A,HMOX1,HSD11B2,LEP,MCL1,NDRG1,PKM,PLAUR,PTGS2,RGS1,RGS5,SLC1A3,SORL1,TFRC,TJP1	ARNT,Akt,CEBPA,CEBPB,HIF1A,JUN,MAX,MYC,NFKB1,NFkB (complex),PPARG,RELA,SP1,SRC,STAT1,STAT3,TP53,VHL,cobalt chloride	
P1	 	glucocorticoid	 	chemical drug	 	0.177	 	0.048	-0.164	2.91E-06	ADRB2,AGT,ALDH3A1,BMP6,CCL13,CCL2,CCL3,CCND3,CD163,CD69,CDK4,CEBPD,CLDN5,CLOCK,COL1A1,CRIP1,CSF1R,CTGF,CXCL2,CXCL8,CXCR4,CYP11A1,DBP,DUSP1,EDN1,FCER2,G6PD,GLUL,GOT1,GPX3,GRN,HMOX1,HRAS,IGFBP3,IL10RA,IL6,LEP,LPIN1,MAOA,MIF,MMP9,MT2A,MYC,NCF2,NFKBIA,NGF,NR4A2,ODC1,OGN,ORM1,PFKL,PLAT,POMC,PRNP,PTGS2,SELE,SGK1,SOCS3,SPP1,STC1,STX11,VCAM1	Ap1,IFNG,IL1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TNF,Tgf beta,glucocorticoid	
P1	 	GATA1	0.019	transcription regulator	 	-1.677	 	0.215	-2.883	2.92E-06	ACTN1,ALAS2,ARHGAP4,BCL2L1,BMP6,BTG2,BZW2,CCND2,CCND3,CCR1,CD36,CDK4,CDKN2C,CHCHD6,CPA3,EGR1,EPB42,ETS1,FCER1A,FHL1,FOSB,GYPE,HIPK2,HSPA9,INHBB,JUNB,KDR,KIT,LEPR,LYZ,MAMDC2,MBP,MECOM,MS4A2,MYC,MYCN,NHP2,NOP2,NR4A2,PIGQ,PLXNA1,POLD1,SCIN,SLC19A1,SRC,SRM,ST3GAL6,TEK,TFF3,TFRC,TGM2,ZFPM1	Ap1,CEBPA,CEBPB,CREBBP,FOXO1,GATA1,HDAC1,IRF8,JUN,MYB,MYC,NFKBIA,NFkB (complex),RELA,SPI1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	WNT3A	0.058	cytokine	Inhibited	-2.537	 	0.205	-4.022	3.01E-06	ADM2,ALDH1A3,ALPL,ANGPT1,ARRDC4,AXIN2,BMP2,BMP4,CCL3L3,CCND2,CD68,CDH2,COL1A1,CTGF,CXCL12,CYR61,DDIT4,DPAGT1,DVL2,EDN1,EGR2,EPAS1,ETV5,GAP43,GPNMB,GSK3B,HEY2,ID1,IL6,IRS2,IRX3,JUN,MESP1,MMD,MT1X,MYC,NDNF,OGN,PLIN1,PMEPA1,PMP22,PTGS2,RHOU,SDC4,SFRP2,SLC7A1,SLC7A2,SOX9,SPARC,SPRY1,THBS1,THY1,TMEM158,TMEM2,TNFRSF19,TRIB3,VCAM1	APC,Akt,Ap1,CTNNB1,ERK1/2,HDAC1,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TCF,TP53,WNT3A	
P1	 	N-acetyl-L-cysteine	 	chemical drug	 	-0.758	bias	-0.262	1.047	3.06E-06	ACTA1,ADM,ATF4,BMP2,BSG,CASP4,CAV1,CCL2,CCND2,CD36,CD86,COL1A1,CTGF,CXCL8,CXCR4,CYBA,CYR61,DDIT3,EDN1,EGR1,FGF2,FOS,GCLM,GLB1,HBEGF,HDC,HIF1A,HMOX1,HSPA5,IL6,ITGAM,JUN,LEP,MMP2,MMP9,MYC,MYH11,NCF2,NQO1,OSGIN1,PIN1,PLAUR,PPRC1,PTGS2,RHOB,SELE,SPP1,TGFBR2,TNFRSF10B,VCAM1,XAF1	Ap1,ERK1/2,JUN,Jnk,N-acetyl-L-cysteine,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT3,TP53,hydrogen peroxide	
P1	 	ZBTB17	0.327	transcription regulator	 	-1.510	bias	0.424	-2.699	3.11E-06	BTG3,CDKN1C,CDKN2B,DDIT3,EGR1,IER3,JUN,LDLR,LRRN3,RRM2B,SPTBN1,ZFP36	HIF1A,JUN,MAX,MYC,SP1,TP53,ZBTB17	
P1	 	HOXA9	1.381	transcription regulator	 	-0.643	 	0.243	-1.564	3.15E-06	ADGRG1,AHCYL1,ALDH1A1,CALCRL,CBX6,CCL2,CCL3,CD36,CELF1,CELF2,CLCN7,CTSG,EDNRA,ETS2,FCGRT,FZD5,GLRX,GNG10,GPR183,HIGD1A,HOXA9,IER2,INPPL1,IRX3,IRX6,JUN,JUNB,KIT,LYN,LYZ,MAFG,MYC,PCMT1,PIK3R2,PPP1R16B,RPP40,S100A8,SDC4,SDCBP,SELE,SERINC2,SPP1,TPR,TSC22D1,VHL,WSB1	CREBBP,EP300,HOXA9,NFkB (complex),RELA,STAT1,STAT3	
P1	 	tyrphostin AG 1478	 	chemical - kinase inhibitor	 	0.318	bias	-0.380	2.134	3.15E-06	BCL2L1,CAV1,CCL2,COL8A1,CXCL8,CXCR4,EDN1,ELN,FOS,GFPT1,HBEGF,HIF1A,IL6,ITGAM,MCL1,MME,MMP2,MMP9,NCF2,PTGS2,PTTG1,RUNX1,S1PR3,VCAM1	ATF2,EGF,EGFR,ERK1/2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,SRC,STAT3,TP53,tyrphostin AG 1478	
P1	 	FOLR1	-0.039	transporter	 	 	 	 	 	3.17E-06	ADH1C,ALDOC,AOC3,AP1S2,ATP6V1B2,BCAT2,BIRC3,CAT,CAV1,CELF2,CLPTM1,DNASE2,DTD1,FBXO3,GBA,GLRX,GPAM,LPAR1,LSP1,LYZ,MDK,PDCD4,PFN1,RPS24,SLC3A2,SORD,ST3GAL3,ST3GAL4,ST3GAL6,WDFY1	 	
P1	 	5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1')-glycerol	 	chemical - endogenous non-mammalian	Inhibited	-3.024	bias	0.419	-5.240	3.34E-06	AQP9,ATF3,CCL2,CCL3L3,CCL8,CMKLR1,CXCL2,CXCL8,DUSP1,EGR2,HBEGF,IDO1,IER3,IFIT2,IL18RAP,MMP9,NFKBIZ,NR4A3,PCSK5,PTGS2,RCAN1,RGS1,RGS16,SDC4,SERPINE2,SOCS3,TNFAIP3,VCAM1	5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1')-glycerol,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF	
P1	 	ADIPOQ	-1.670	other	 	0.460	 	0.069	0.112	3.54E-06	ACACA,ACLY,ACSM5,ACTA1,ADIPOQ,ADIPOR2,BMP2,CCL2,CD36,CLEC10A,CMKLR1,COL3A1,CTGF,CXCL8,DUSP1,EGR1,FOS,HBEGF,HMOX1,IL6,LDLR,LEP,LEPR,LHCGR,NCF2,NFKBIA,NOX4,PDCD4,PFKFB1,PRDX5,PTGS2,SHC1,SLC27A1,SLC2A3,TIMP1,TSC2,UCP2,VCAM1,VEGFC	ADIPOQ,ERK1/2,FOXO1,Growth hormone,HIF1A,Insulin,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,RNA polymerase II,SMAD3,SREBF1,STAT3,fatty acid,palmitic acid	
P1	 	NR3C2	-0.448	ligand-dependent nuclear receptor	 	-1.418	 	0.125	-2.049	3.66E-06	ABCC9,ADAMTS1,AGT,BCL2L1,CACNA1H,CCL3L3,COL1A1,COL3A1,CTGF,DDIT4,EDN1,EGR1,FGF2,FKBP1A,FKBP4,GPX3,GUCY1A3,HSPA9,IL6,KDR,KLF9,MSRB1,NOX4,NR4A2,PROCR,PTGS2,SEMA3C,SERP2,SERPINA3,SGK1,ST3GAL3,TACC2	AR,Ap1,EP300,FOS,FOXO3,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,RELA,STAT1,STAT3,aldosterone,corticosterone,glucocorticoid	
P1	 	N-cor	 	group	 	0.437	bias	-0.441	2.015	3.86E-06	ACACA,ADIPOQ,ADIPOR2,AXIN2,BIN1,CCR1,CD36,CIDEC,CXCL14,CXCL2,DHRS3,ELOVL6,ESR1,G6PD,IDH1,IGFBP3,LHPP,MCTP1,MMP9,PLIN1,PLIN2,PTGS2,RGL1,RHOB,RNF144B,SGK1,SNX1	Ap1,CEBPB,ESR2,FOXO1,HDAC1,Hdac,Histone h4,JUN,N-cor,NFKB1,NFKB2,NFKBIA,NFkB (complex),PGR,PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,TNF,progesterone	
P1	 	bicuculline	 	chemical - endogenous non-mammalian	Inhibited	-3.619	bias	0.347	-5.034	3.97E-06	ATF3,BTG2,CYR61,DUSP1,EGR1,EGR2,FOS,FOSB,GADD45B,HSPA8,IER2,JUN,JUNB,KLF4,NR4A2,PTGS2,TIPARP	CREB1,CREBBP,CTNNB1,Cg,Creb,ELK1,EP300,ERK1/2,FOS,HDAC2,Hdac,JUN,L-glutamic acid,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,SP1,SRF,STAT3,TP53,bicuculline	
P1	 	bucladesine	 	chemical toxicant	 	-1.440	bias	0.285	-3.693	4.00E-06	ABCA3,ADAMTS1,ALDH3A1,APOE,ASS1,C5AR1,CD14,CD86,CDH2,CXCL8,CXCR4,CYP11A1,DGKQ,DUSP1,EGR2,ERBB2,FAAH,FCER1A,FOS,FST,GADD45B,GAP43,GDF15,GLUL,H19,HMOX1,ID1,ID4,IGFBP3,IGFBP6,IL6,INHBB,IRS2,JUN,JUNB,KIT,LDLR,LEP,LIPE,LRRN3,LXN,MCAM,MMP2,MMP9,MYC,NGF,NR4A2,NR4A3,ODC1,PADI4,PDE8B,POMC,PTGER4,PTGS2,QSOX1,RGN,RGS16,SIGMAR1,SOCS3,SOX17,SOX7,SRGN,STC1,TF,TGFBR3,THBD,TIMP1,TINAGL1,TYRO3,ZDHHC7	CEBPB,CREB1,Creb,ESR2,IL6,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PGR,Pka,RELA,SP1,STAT1,STAT3,TNF,bucladesine,cyclic AMP,progesterone	
P1	 	GATA4	0.051	transcription regulator	 	-1.858	 	0.090	-2.373	4.05E-06	ACACA,ACTA1,ACTG2,ADORA1,ATG7,ATP2A2,BCL2L1,CASQ2,CLSTN2,CNFN,COL1A1,COL1A2,COL3A1,CRABP2,CTGF,CTHRC1,CYP11A1,DAB2,ECM2,EDN1,EMX2,EPHX1,EVPL,FGF2,FOS,HSPA5,HSPB7,INHBB,KCNJ2,LHCGR,LOC102724428/SIK1,LTBP2,NR5A2,PLA2G2A,PTPRB,SGPL1,SOX9,SPP1,TAGLN,THBS4,TIMP1,TPM1,VCAM1	CEBPB,GATA4,PPARA,PPARG,PPARGC1A,RXRA,THRB	
P1	 	CXCL12	0.751	cytokine	 	-1.964	bias	0.299	-3.935	4.08E-06	ACP5,AKR1C3,AXL,BCL2L1,BMP2,BMP6,CANX,CCL2,CD36,CD69,CDKN1C,CELF1,CPSF1,CTSK,CXCL12,CXCL8,CXCR4,EGR1,ERBB2,ERCC1,FLNA,FOS,FYN,GSR,ID1,IFI27,IFNAR2,IL6,IRF3,JUN,JUNB,KIT,MAPK8IP2,MAPRE3,MMP2,MMP9,MYC,NR2F6,PKD1,PRKCD,PTGS2,RANGAP1,SOCS2,SOCS3,TF,TIMP1,TNFRSF10B,TNFSF10	Ap1,CXCL12,CXCR4,ERK1/2,ESR2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	L-triiodothyronine	 	chemical - endogenous mammalian	 	1.699	 	0.162	0.353	4.12E-06	ACTA1,ACTG2,ADIPOQ,ADM,ADRB2,AGT,AGTRAP,ALAS2,ALDH1A1,APOB,APOC1,ARSA,ATIC,ATP2A2,CMKLR1,CS,CST3,CTGF,CTSH,CXCL12,CYP11A1,DBP,DUSP1,DUSP5,EDN1,EGR1,EGR2,EIF4EBP2,ENPP2,ESR1,FOS,G6PD,H6PD,HIF1A,HINT1,HP,ID3,IGFBP3,IGFBP4,IL6,ITGA7,LEP,LHCGR,LIPE,LMNA,LYZ,MAMDC2,MBP,ME1,MMP9,MYC,NME1,NR1D1,NR5A2,ODC1,PDK4,PLA2G2A,POR,PTGDS,PTGS2,RAB34,RARA,RCAN2,RELN,RET,RGN,RPS6KA4,SLC27A1,SLC9A1,SORBS1,SRM,ST3GAL4,TF,THRA,THRSP,UBA1,UCP2	CEBPA,CEBPB,EDN1,FOS,FOXO1,Growth hormone,HIF1A,Ins1,Insulin,JUN,L-triiodothyronine,NCOR2,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3,THRB	
P1	 	trovafloxacin	 	chemical drug	Inhibited	-4.491	 	0.192	-5.430	4.26E-06	ADRB2,BIRC3,CHFR,CXCL2,DNAJB2,ETS2,FOS,HMOX1,IL6,ISG20,JUNB,LDLR,MAP3K8,MED20,NEDD4L,NFKBIA,PHLDA1,SELE,SOCS2,SOCS3,TGM2,THBS1,TNFAIP3,UBE2I	IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,trovafloxacin	
P1	 	prednisolone	 	chemical drug	 	-1.784	bias	-0.257	0.138	4.26E-06	APOE,ARSA,ATG7,ATG9A,BCL2L1,BIRC3,BTG1,BYSL,CAT,CCL2,CD163,CEBPD,CTSB,CXCR4,CYGB,DUSP1,DUSP10,EDN1,EDNRA,ESR1,FMO2,GAA,GABARAP,GABARAPL1,GM2A,GPX3,HGS,HSPA8,IL6,IRS2,ISG20,ITGAM,KLF9,LOC102724428/SIK1,MCL1,MYCN,NLGN4X,NQO2,PLAT,POMC,PRNP,PTGS2,RARRES3,RNF38,SGK1,SPHK2,SPP1,SQSTM1,SRGN,TGM2,TNFAIP3,TNFSF10,TPO,UVRAG,ZC3HC1,ZFP36L2	Ap1,CREB1,CSF2,EP300,ESR1,ESR2,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARG,PTGS2,RELA,SP1,STAT1,STAT3,TP53,beta-estradiol,prednisolone	
P1	 	methapyrilene	 	chemical drug	 	1.342	 	-0.048	1.555	4.28E-06	ACADM,ALDOA,ANXA5,APOE,ASS1,ATF3,ATF4,ATP6V1B2,AZIN1,BTG2,CAT,CBS/CBSL,CD36,CDC34,CES1,CST3,CTSB,DDIT3,ENPP2,FBP1,GADD45A,GRB14,GSK3B,GSS,GSTM1,HMOX1,HSPA5,IFRD1,MIPEP,MYC,NR2F6,NSFL1C,ODC1,OPLAH,ORM1,PC,SLC3A2,TUBB,TXNRD1	 	
P1	 	epigallocatechin-gallate	 	chemical drug	 	0.622	 	-0.179	1.804	4.52E-06	ACP5,ANGPT1,APOB,AXIN1,AXL,BCL2L1,BHLHE41,CAT,CCL2,CCL3L3,CLDN5,COL18A1,CSF2RA,CTGF,CTSK,CXCL8,CYR61,DAPK2,DIABLO,EDN1,EGR1,ERBB2,ESR1,FOS,FOSB,GADD45A,GADD45B,GBP4,GDI1,GJB2,GSR,HIF1A,HMOX1,IL6,JUN,JUNB,KDR,LDLR,LEP,LTBR,MMP2,MMP9,MYC,NFKBIA,NOTCH1,PRKCE,PTGS2,RBP4,SFRP1,TFRC,TIMP1,TNFRSF10B,TNFSF10,VCAM1,VEGFC	ERK1/2,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TNF,epigallocatechin-gallate	
P1	 	NUPR1	1.227	transcription regulator	 	-1.872	 	-0.148	-0.372	4.86E-06	--,ADGRG1,ADM,ADRB2,AEN,AKAP12,ALDH5A1,ALDOC,ALG8,AS3MT,ASIC1,ATF3,AVPI1,B3GAT3,BTG1,CARD8,CARMIL1,CD68,CDK4,CEP170B,CNPY4,COL1A2,COL3A1,CREB5,CXCL8,CXCR4,CYR61,CYSTM1,DDIT3,DHCR24,DHTKD1,DPH6,DUSP5,ETS1,ETV6,FAM162A,FBXO3,FUCA1,GADD45A,GDF15,GPR1,HBEGF,HSPA2,IFIT2,IRF2BP2,IRS2,KLF4,KLF6,LHFPL2,LMAN2L,LOC102724428/SIK1,LRP8,MAFG,MEGF9,MKL2,MMD,MSANTD3,MT1X,MYC,NCKIPSD,NDRG1,NR1D1,NRSN2,NSF,NUPR1,P3H1,P4HA2,PEA15,PFKFB3,PHLDA1,PMP22,POLA2,PPFIBP2,PPP1R15A,PRAG1,PRND,PRNP,RAB11FIP5,RAB32,RAB38,RCL1,RPA1,SAMD4A,SESN2,SIGMAR1,SLC39A8,SLF1,SPATS2L,SYTL2,TESK1,TMEM158,TMEM19,TMEM268,TNIP1,TOB1,TP53BP1,TRIB1,TRIB3,UNC5B,UPP1,USP36,ZFAND2A,ZNF296,ZPR1	EGR1,FOXO1,FOXO3,MXI1,NFkB (complex),NUPR1,TP53	
P1	 	ACVRL1	-0.351	kinase	 	-0.454	 	0.091	-0.750	4.88E-06	CXCL12,CXCL8,CXCR4,EFNB2,GDF15,ID1,KDR,LYVE1,MYC,PLAT,PLAUR,SELE,SMAD6,SMAD7,TAGLN	ACVRL1,ENG,GATA4,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,RUNX2,SMAD1,SMAD3,SMAD5,SP1,STAT3,Smad	
P1	 	ELF4	0.122	transcription regulator	 	-0.767	 	0.234	-1.627	4.88E-06	CBX1,CXCL2,CXCL8,DUSP1,DUSP5,HDC,KIT,KLF2,KLF4,LYZ,MT1G,NDUFS8,PLEC,RCAN1,SPP1	ELF4,IFNG,JUN,NFkB (complex),RELA,STAT1,STAT3	
P1	 	MTOR	0.516	kinase	 	0.773	 	0.101	0.121	4.96E-06	ACACA,ACADM,ACLY,ADM,AKR1B1,ATG7,ATP2A2,ATP2B1,BCL2L1,CD86,CEBPD,CS,CXCR4,CYP11A1,DDAH2,DDIT3,DDIT4,DLG4,ENO1,EPRS,ERCC1,FAF1,FKBP1A,GAP43,GLG1,GSTM5,HADHA,HIF1A,IL6,IRAK1,IRS2,KCND2,LEP,LHCGR,MBP,MCL1,MIA,MMP9,MTOR,MYC,PDK4,PFN1,PGP,PHLPP1,PIP5K1C,PKM,PRDX5,PSMB5,PYGB,RAP1GDS1,S1PR1,SLC12A2,SMPD1,SOCS3,SQSTM1,SRC,SRPX,TCEB2,TNFSF10,TSC2,TXNL1,VCAM1	AKT1,Akt,Ap1,GSK3B,HIF1A,JUN,MTOR,MYC,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,sirolimus	
P1	 	methotrexate	 	chemical drug	 	0.909	 	0.074	0.453	4.97E-06	ACADM,ACADVL,ACSL4,ADIPOR2,AK4,ALDOA,ASS1,BNIP3L,BTG2,C1QB,C1R,C2,C6,C7,CASP4,CCL13,CCL2,CCL3,CCL3L1,CCL8,CES1,CFB,CXCL12,CXCL8,DGAT2,DUSP1,DUSP10,DUSP14,EPAS1,GAP43,GAPDH,GPAM,GSR,HADHA,HMGCS1,HMOX1,ID1,IGFBP3,IL6,ITGA1,LBP,LPIN1,LY96,MAPKAPK2,MECR,MYC,NQO1,NR4A2,ORM1,PECR,PEX7,PTGS2,SLC31A2,SOCS3,SPP1,TEF,TOB1,VCAM1	Ap1,ERK1/2,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,methotrexate	
P1	 	calcitriol	 	chemical drug	 	-1.518	 	-0.032	-1.270	5.14E-06	AAAS,ABCC3,ABL1,ALDH1A2,ATP2B1,BCL2L1,CCND3,CD14,CDC20,CDCA5,CEBPD,CES1,CHTF18,CSE1L,CSF1R,CTSK,CXCL2,CXCL8,CYR61,DOK5,DUSP1,DUSP10,EDN1,EGR1,ERBB2,ESR1,ETV5,FAM107A,FBN2,FCER2,FECH,FOS,G6PD,GADD45A,GAPDH,GDPD5,GRK5,H2AFZ,HBEGF,ID1,IDH1,IER3,IGFBP3,IL10RA,IL6,ITGAM,JUN,KLF4,KPNA2,LIG1,LPAR1,MAF,MCL1,MCM2,MYC,NEDD9,NGF,NOX4,NUP43,NUP93,NUPR1,NUSAP1,ODC1,OLFML2A,PALMD,PDCD4,PMEPA1,PRKCD,PTGFR,PTGS2,RAB38,RARRES1,RBPMS,RGCC,RNF144A,S100A8,S100A9,SMAD7,SOCS3,SPP1,SPRY2,STXBP6,SULF1,THBD,THBS1,THRA,TJP1,TJP2,TMEM100,TNFAIP3,TNFRSF10B,TNFSF10,TXN,UCP2,WSB1	ERK,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,calcitriol,prostaglandin E2	
P1	 	STAT5A	-0.015	transcription regulator	 	-1.496	 	0.109	-2.004	5.16E-06	ADIPOQ,AHSA2,AKR1C3,ALDH3A1,AXIN2,BCL2L1,BIRC3,CASP4,CCL3L3,CCND2,CCND3,CD24,CD68,CDK4,CPA4,CYP1B1,DUSP5,EPAS1,ERAP2,ESR1,FCER1G,FOS,FOSB,GADD45A,GSTT1,HIST1H1C,HIST2H2AA3/HIST2H2AA4,ID1,IL6,KIT,LTBR,MAF,MAL2,MCL1,MYC,MYH1,NOL3,NR4A2,PODXL2,PPFIBP2,PRSS23,QPCT,QPRT,RARRES3,RPA1,S100P,SERP2,SERPINA3,SLC2A10,SLC2A3,SLC7A8,SNTB1,SOCS2,SOCS3,SYTL2,TFF3,TGFBR2,TIMP4,TM4SF1,TNFRSF14,TNFRSF4,TSPAN13,WARS,ZFP36,ZP3	CEBPB,HIF1A,IGF1,IL2,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SMAD3,SP1,STAT1,STAT3,STAT5A,STAT5B,STAT5a/b,TCF3,TNF	
P1	 	fulvestrant	 	chemical drug	Inhibited	-2.149	 	-0.113	-1.310	5.32E-06	ABL1,ADRB2,ASNS,ATF4,AXL,BMP2,BMP4,CASP4,CAST,CAV1,CCDC80,CCL2,CDC20,CDKN2C,CHTF18,COMT,CXCL12,CYP11A1,CYR61,DDIT4,EGR1,EGR3,ESR1,FKBP1A,FNTA,FOS,G6PD,GADD45A,GJB2,GUCY1A3,HRAS,ID1,IER3,INHBB,JUN,LDLR,LEPR,LRP8,MCM2,MMD,MYC,NME1,NRP1,PDCD4,POLA2,PRSS23,PTGS2,PTTG1,RNASEH2A,RNF126,SIAH2,SLC22A5,SLC7A5,SMPD1,SQSTM1,STC1,TFF3,TFRC,TGFBR3,VCAM1,ZMAT3	Ap1,CEBPB,CTNNB1,EGR1,ESR1,ESR2,HDAC1,JUN,MYC,NFKB1,NFKB2,NFkB (complex),NOTCH1,PGR,SMAD3,SP1,STAT3,TP53,TP73,Vegf,fulvestrant,progesterone	
P1	 	Gm-csf	 	group	 	-1.122	bias	0.428	-2.792	5.93E-06	BCL2L1,CCND2,CD14,CD163,CD1C,CD209,CD86,CXCL8,FOS,IL6,IRAK1,JUN,JUNB,LAMP3,MCL1,MMP9,MYC,PTGS2,SOCS2,SOCS3	Ap1,CSF2RB,ELK1,ERK1/2,FOS,Gm-csf,JUN,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT,STAT3,STAT5A,STAT5a/b	
P1	 	SMAD1	-0.104	transcription regulator	 	-0.197	bias	0.407	-1.694	6.03E-06	ALPL,BCL2L1,BTG2,CDKN2B,COCH,COL1A1,COL1A2,CTGF,CXCL2,GADD45B,HEY1,ID1,MYC,SMAD6,SMAD7,SOX9,SPP1	Ap1,EGR1,ESR1,GATA4,HIF1A,MYOCD,NFkB (complex),NOTCH1,RELA,RUNX2,RXRA,SMAD1,SMAD3,SP1,STAT3,Smad,TP53,VHL	
P1	 	baicalein	 	chemical - endogenous non-mammalian	 	1.153	bias	-0.330	2.371	6.20E-06	BCL2L1,CCL2,CCND3,CXCL8,DDIT3,FOS,HMOX1,IL6,JUN,KDR,MCL1,MMP2,MMP9,PLA2G4A,PTGS2,PTTG1,TIMP1,VCAM1	Akt,Ap1,CREB1,ERK,ESR1,FOS,HIF1A,JUN,Jnk,NFATC2,NFkB (complex),Nfat (family),Pkc(s),RELA,SMAD3,STAT3,TP53,baicalein	
P1	 	CTBP1	0.487	enzyme	 	-1.913	bias	-0.263	-1.013	6.57E-06	CCNG2,COL1A2,CSF1R,ENPP2,FAT1,FOS,FSCN1,KRT8,MIA,MMD,SMAD6,SPRY2,THBS1,VCAN	CTBP1,HDAC1,SIN3A,TP53,histone deacetylase	
P1	 	CSF1	0.402	cytokine	 	1.256	bias	0.364	-0.961	6.59E-06	ACP5,APOE,BCL2L1,CCL2,CCL3,CCND2,CD163,CD163L1,CD209,CD68,CDK4,CSF1R,CTSK,CXCL2,CYP11A1,DOK2,DUSP1,DUSP5,EGR1,EGR3,ETS2,FCER1G,FCGR3A/FCGR3B,FOLR2,FOS,GDF15,HSPA5,IL10RA,IL11RA,IL6,ITGAM,JUN,JUNB,MARCO,MMP9,MYC,PIK3R2,RUNX1,SFRP1,SPI1,STAB1,STX6,THBS1,VCAM1	CREB1,CSF1,CSF2,ERK,IFNG,IL10,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	FOXO1	0.014	transcription regulator	 	-0.675	bias	0.324	-3.070	6.80E-06	ACACA,ACLY,ADIPOQ,AFF3,ANGPTL4,AQP9,ATP6V0B,ATP6V1D,BIRC3,CAT,CCNG2,CDKN1C,CDKN2B,CDKN2C,CIDEA,CLDN5,CS,CTGF,CTSK,CXCL8,DDIT4,EBF1,EDN1,EFHD1,EGR1,EGR2,EIF4EBP1,ELOVL6,FAM65B,FOS,FOSB,GADD45A,GADD45B,GPAM,HMOX1,HSPA5,IER3,IL6,IRS2,ITGA3,JUN,JUNB,KLF2,KLF4,LAMP2,LEP,LHCGR,LPIN2,LTBR,ME1,MMP9,MRPL14,MRPL55,MRPS12,MRPS18A,MRPS2,MVD,MYC,MYL3,NDUFA7,NDUFA9,NDUFAF2,NDUFAF4,NUSAP1,PCK2,PDK4,POMC,PPP1R15A,PSMB6,SGK1,SQLE,THBS1,TNFSF10,TRIB3,VCAM1	AR,Akt,CEBPA,EGR1,ERK1/2,FOXO1,HIF1A,IL6,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	INSIG1	0.356	other	Inhibited	-2.578	bias	-0.491	0.025	6.84E-06	ABCG1,ACACA,ACLY,ACSL4,APOE,CD68,CXCL2,CXCR4,CYP51A1,DHCR24,DHCR7,ELOVL6,G6PD,GPAM,HMGCS1,IL6,IRS2,LDLR,LIPG,LPIN1,LSS,MARCO,NFKBIZ,PCYT2,PLIN2,S100A8,S100A9,SCAP,SQLE,TM7SF2,UCP2	ESR1,INSIG1,NFE2L2,NFkB (complex),PPARG,PPARGC1A,RELA,SREBF1,SREBF2,STAT3,Srebp,TP53,USF1,cholesterol	
P1	 	mir-122	0.011	microrna	Inhibited	-3.395	bias	-0.444	-1.051	7.12E-06	ACTR1A,ADGRB2,ALDOA,BCAT2,CDC42BPB,CS,FKBP1A,G6PD,GNPDA1,GYS1,H1F0,IL6,KIF5B,MAP1B,MAP3K12,MTHFD2,PKM,RAD21,SH3GL1,SLC1A5,SLC7A1,TGM2,TNPO2,VAV3,VPS4A,VPS4B,WARS,YARS	 	
P1	 	15-deoxy-delta-12,14 -PGJ 2	 	chemical - endogenous non-mammalian	 	0.089	 	-0.161	1.148	7.18E-06	BCL2L1,BIRC3,CCL2,CCL3,CCND2,CD36,CDK4,CEBPD,COL1A1,COL1A2,CTGF,CTSB,CTSD,CXCL8,DDIT3,EGR1,ESR1,FKBP4,FOS,FTH1,GADD45A,GCLM,GDF15,GSR,HMOX1,IL6,ITGAM,JUN,KDR,KLF4,MCL1,MMP9,MYC,MYH11,NFKBIA,NOX4,NQO1,PTGES2,PTGS2,RARRES3,SELE,SLC9A1,SOCS3,SPP1,TXNRD1,VCAM1	15-deoxy-delta-12,14 -PGJ 2,Ap1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TNF,nitric oxide	
P1	 	tacrolimus	 	chemical drug	 	-0.466	 	-0.158	0.542	7.29E-06	ACTA1,ANGPT1,BCL2L1,CARD8,CCL2,CD36,CDK4,COL1A1,COL3A1,CXCL2,CXCL8,CXCR4,EDN1,EGR1,FLNA,FOS,FOSB,GAP43,GNPDA1,HOMER2,ID3,JUN,JUNB,KCNK3,MAF,MYC,MYH11,NFKBIA,NME1,ODC1,ORM1,PA2G4,PDCD4,PDE3B,PLIN2,PRNP,PTGS2,PTPRF,SDCBP,SIAH2,SLIT2,SMAD7,SPP1,TJP1,TLE1,TMEM100,TNFRSF12A,TNFSF10,VEGFC	Ap1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF,tacrolimus	
P1	 	RARB	-0.239	ligand-dependent nuclear receptor	 	1.299	bias	0.323	0.156	7.54E-06	ACADM,ARHGAP4,CDH5,CDKN2B,CXCL2,CXCL8,EGR1,ETS1,FOLR2,GADD45A,GAP43,ID1,ID3,IFI27,IGFBP3,IL6,MAP2K3,PTGS2,RAB5A,RARA,RET,SPP1,TCEA1,THBD,TJP1,VEGFC	Ap1,CEBPA,CEBPB,ESR1,FOS,JUN,NFATC2,NFkB (complex),Nfat (family),PPARG,RARB,RARG,RELA,RNA polymerase II,RXRA,SP1,STAT3,isotretinoin,tretinoin	
P1	 	SU6656	 	chemical toxicant	Activated	2.534	bias	-0.501	 	7.83E-06	ADM,ATF3,CTGF,DDIT3,EGR1,ETS2,GFPT2,IER3,JUNB,KRT8,MYC,NR4A2,PHLDA1,PTGS2,SOCS3	ATF2,Akt,Ap1,CEBPA,CEBPB,EGFR,FOSL1,HIF1A,JUN,MAP2K1/2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,SU6656,TP53	
P1	 	FGF19	-0.001	growth factor	 	-1.942	 	-0.042	-1.833	8.35E-06	ACACA,ACLY,ALDH1A1,APOE,BCL2L1,BTG3,CD36,CXCL2,EGR1,ELOVL3,FBP1,FOS,G0S2,GADD45A,ID1,LEP,LEPR,MCAM,MME,PTGDS,RGS16,SERPINA3,SGK1,SLC2A5,SQLE,TCEA1,THRSP	ADIPOQ,CEBPA,CEBPB,ERK,ERK1/2,FGF19,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	Ca2+	 	chemical - endogenous mammalian	 	-1.289	bias	0.271	-3.221	8.44E-06	ATF3,ATP2A2,BCL2L1,CCND2,CCND3,CD86,CDK4,CEBPD,COL1A1,CSTF2,CUL9,CXCL8,CXCR4,CYP1B1,CYR61,DBP,DDIT3,DNASE1L3,DUSP1,EDN1,EGR1,ELK1,FAAH,FGF2,FOS,GRK5,HDC,HSPA5,ID1,ID3,IL6,IRS2,ITGA3,ITPR2,JUN,JUNB,KCND2,KCNG1,KLF4,KRT8,MCAM,MGP,MMP9,NDRG1,NFKBIA,NR1D1,NR4A3,ODC1,PEBP1,PLS3,PTGS2,PTTG1,S100A8,S100A9,SGK1,SPP1,STC1,TAGLN,TNFRSF10B,VEGFD	CREB1,Ca2+,ERK1/2,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,SP1,STAT3,TNF,TP53,hydrogen peroxide	
P1	 	CDK9	0.134	kinase	 	-1.832	bias	0.451	-3.168	8.78E-06	CCND2,COL1A1,CXCL2,CXCL8,CXCR4,FOS,G6PD,HNRNPH1,IL6,MMP9,MYC,NCL,NFKBIA,ODC1,PDK4,RUNX1,SELE,STC2,TNFAIP3	Ap1,CDK9,CREBBP,CTNNB1,EP300,ESR1,HIF1A,Histone h3,MMP9,MYC,NFKB1,NFkB (complex),NOTCH1,RELA,RNA polymerase II,SP1,STAT3,TP53,TP73	
P1	 	CREM	0.186	transcription regulator	 	-0.975	 	0.123	-1.591	8.79E-06	ADRB2,APOE,APOLD1,ATF3,ATP2A2,BTG2,CCND2,CD86,CH25H,CIART,COL3A1,COL8A1,CSRNP1,CXCL8,CYP51A1,DUSP1,DUSP14,EGR1,EGR2,FOS,GADD45B,HMGCS1,HSPA4,IRAK1,IRS2,JUNB,LDLR,LSS,MCL1,MKNK2,MNS1,MSMO1,NOTCH1,NR4A2,PPP1R15A,RHOB,SERTAD1,SIAH2,THBS1,TIPARP	CEBPB,CREB1,CREBBP,CREM,CTNNB1,Creb,EP300,JUN,Lh,NFE2L2,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,RNA polymerase II,SREBF2,STAT1,STAT3,STAT5B,TP53,cholesterol	
P1	 	ATG7	1.120	enzyme	 	-0.925	 	-0.201	-0.148	9.02E-06	ATF4,BMF,CDH2,CDH5,CTGF,CTSB,CXCL8,GSTM5,IL6,IRF3,MARCO,NFKBIA,NQO1,RCAN1,SOCS3,TEK,TGFBR2	ATG7,BACH1,CEBPA,CEBPB,IL17A,IL1B,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SQSTM1,STAT1,STAT3,TP53	
P1	 	BAPTA-AM	 	chemical reagent	 	0.690	bias	-0.355	2.119	9.02E-06	ATF3,CCL2,COL1A1,CXCL8,DDIT3,EGR1,ELK1,FOS,IL6,JUN,MMP2,PTGS2,SELE,SOCS2,SOCS3,SPP1,VCAM1	Ap1,BAPTA-AM,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT3	
P1	 	SMAD7	-1.107	transcription regulator	 	-0.870	 	-0.164	0.021	9.27E-06	ADH1C,BMP2,BZW2,CCL2,CDH2,CDKN2B,CDKN2C,CFC1/CFC1B,COL1A1,COL1A2,COL3A1,COL6A1,COL6A3,CTGF,FST,GADD45A,HBEGF,HMOX1,ITGA7,KRT8,LTBP2,MATN2,MMP2,MMP9,MYC,NFKBIA,NID2,PLAT,PMEPA1,SMAD7,SOX9,TAGLN,TGFBR2,TIMP1,TXN	ATF2,Ap1,EGFR,HIF1A,JUN,NFKBIA,NFkB (complex),PI3K (complex),RAC1,RELA,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad	
P1	 	pioglitazone	 	chemical drug	 	-0.537	 	0.054	-0.863	9.86E-06	ABCG1,ACTA1,ADIPOQ,ADIPOR2,ANGPTL4,APOB,APOE,ATP2A2,CAT,CAV1,CD36,CD86,CDK4,CEBPD,CMKLR1,CTGF,CXCL8,EGR1,FBP1,FOS,HMOX1,IL6,IRS2,ITGAM,KLF4,LDLR,LEP,LEPR,LIPE,LPIN1,MMP9,NCF2,NR4A3,PC,PDE3B,PFKL,PLIN1,PLIN2,PTGS2,RBP4,SLC27A1,UCP2	ADIPOQ,APOE,CTNNB1,FOXO1,Growth hormone,HIF1A,Insulin,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3,TNF,pioglitazone	
P1	 	lithium chloride	 	chemical drug	 	0.617	 	0.232	-0.610	1.06E-05	ASS1,AXIN2,BMP2,BMP4,BSG,CD4,CTAGE9 (includes others),DPAGT1,FOS,FSCN1,GDF15,GSK3B,HEYL,HMOX1,MMP2,MT1G,MT2A,MYC,NKD2,NOTCH1,PKD1,PLIN2,POMC,PTGS2,PTX3,RARA,SOX9,TMEM2,TNFRSF10B,TNFSF10,VCAN	AKT1,Akt,CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TCF,TNF,TP53,lithium chloride	
P1	 	imatinib	 	chemical drug	Inhibited	-2.581	 	-0.098	-2.082	1.07E-05	ABL1,BCL2L1,BIRC7,BMP2,CCND2,CDKN2C,COL1A1,COL3A1,CXCL12,CXCR4,DAB2,HMOX1,IL6,ITGA1,ITGAM,KDR,KIT,LYN,MCL1,MME,MTOR,MYC,PLIN2,PRNP,SMPD1,SOCS2,TNFRSF10B	CEBPA,CEBPB,IL6,JUN,KIT,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT,STAT1,STAT3,STAT4,STAT5a/b,TNF,TP53,imatinib	
P1	 	sorafenib	 	chemical drug	 	-0.318	 	-0.228	0.439	1.10E-05	BCL2L1,CCND2,CCND3,CD69,CDK4,CXCL8,DDIT3,ERN1,HIF1A,HSPA5,MCL1,PPP1R15A	Akt,Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TP53,bortezomib,sorafenib	
P1	 	SMAD4	-0.268	transcription regulator	 	-0.803	 	0.229	-2.197	1.10E-05	ANGPT1,ANGPTL4,APOB,BMP2,BMP4,CCL2,CCND2,CCNG2,CDH2,CDH5,CDKN2B,CELF2,COCH,COL1A2,COL7A1,CTGF,CTSD,CYB561,EDN1,ERBB2,FOS,FSCN1,FST,GADD45A,GADD45B,HMOX1,HP,ID1,IER3,LOC102724788/PRODH,LPAR1,MAPK7,MTOR,MYC,MYCN,NFKBIA,POR,PTGS2,PTX3,RGCC,RUNX1,SELE,SERTAD1,SGK1,SMAD6,SMAD7,SMO,SPI1,THBS1,TIMP1,TPM1,ZFP36	Ap1,EGR1,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TNF,TP53	
P1	 	5-fluorouracil	 	chemical drug	Inhibited	-4.300	 	-0.211	-2.853	1.12E-05	AHSA1,ALDOA,ATF4,ATP5I,BCL2L1,BNIP3L,CANX,CAPNS1,CCT3,CD86,CES2,COL1A2,COPS8,COX8A,CSTB,EEF1G,EGR1,EIF2S2,EIF3C,FBL,FKBP1A,GAP43,GAPDH,GARS,GDF15,GOT2,HADHA,HSPA8,HSPE1,IARS,MCL1,MYC,NCL,NDUFS8,PKM,PSMB2,PSMB5,PSMB7,PSME2,PTGS2,RAE1,RHOB,RPL6,SLC25A6,SNRPB,SQSTM1,SRM,TCEB2,THBS1,TNFRSF10B,TNFRSF12A,TSC22D1,UNG,XPOT	5-fluorouracil,CEBPA,CEBPB,CTNNB1,HDAC1,HDAC2,JUN,MYC,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SIN3A,SP1,STAT1,STAT3,TP53,TP73	
P1	 	lovastatin	 	chemical drug	 	0.659	 	0.134	-0.023	1.12E-05	ACAT2,ADIPOQ,APOE,ATF3,ATF4,BCL2L1,CAT,CCL2,CCND3,CD86,CDK4,CTGF,DDIT3,DHCR7,EBNA1BP2,FAM189B,GAP43,GPX3,HMGCS1,HMOX1,IL6,KLF2,LDLR,LEP,LMNA,MCL1,MVD,MYC,NOX4,PLAT,PTGS2,RHOB,RHOU,SDC4	AKT1,APOE,Akt,Ap1,CTNNB1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,lovastatin	
P1	 	reactive oxygen species	 	chemical toxicant	 	-0.178	bias	0.419	-2.391	1.12E-05	ABCC1,ADAM17,ADIPOQ,BCL2L1,CAT,CCL2,CD24,CSF1R,CTGF,CXCL8,CXCR4,DDIT3,EDN1,EIF4EBP1,ERBB2,ETS1,FGF2,GADD45A,GLRX,HIF1A,HMOX1,HSPA5,IL6,JUN,LEP,LPIN1,MCL1,MYC,PRDX5,PTGS2,TNFAIP3,TNFRSF10B,UCP2,VCAM1	ARNT,Ap1,ERK1/2,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SMAD3,STAT3,VHL,reactive oxygen species	
P1	 	ATP-gamma-S	 	chemical reagent	 	-0.503	 	-0.100	-0.196	1.14E-05	BTG1,CCL13,CCL2,CCL3,CCL8,CCR1,CD55,CD69,CD86,CSF1R,CXCL2,CXCL8,CXCR4,GAP43,IDO1,IL6,MMP9,NCF2,NRP1,PTGS2,THBS1,TRAP1,WARS	ATP-gamma-S,CEBPA,CEBPB,IFNG,IL10,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TNF,TP53	
P1	 	RICTOR	0.059	other	Inhibited	-4.760	bias	-0.363	-1.943	1.15E-05	ATP5D,ATP5G1,ATP6AP1,ATP6V0A2,ATP6V0B,ATP6V1B2,ATP6V1D,ATP6V1E1,ATP6V1F,BCL2L1,BSG,CD4,CD69,COX15,COX17,COX7A2L,COX8A,CYC1,HIF1A,IFIT2,IRS2,LEPR,LHPP,MCL1,NDUFA10,NDUFA7,NDUFA9,NDUFAB1,NDUFB10,NDUFB9,NDUFS3,NDUFS7,NDUFS8,NDUFV1,PRKCE,PSMA3,PSMA4,PSMB10,PSMB2,PSMB5,PSMB6,PSMB7,PSMD14,PSMD7,PSME2,PSME3,PSME4,PTGS2,RGS16,RPL14,RPL6,RPL8,RPL9,RPLP0,RPS2,RPS21,RPS24,SGK1,UQCR10,UQCRC1,VCAM1	AKT1,ATF4,E2F1,EGR1,ERK1/2,FOXO1,GSK3B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RICTOR,SIRT1,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	desmopressin	 	biologic drug	 	-0.379	bias	0.251	-1.371	1.15E-05	ADM,AHNAK,AKR1B1,CAPG,CTSD,CYBA,ENO1,ESAM,F8,FLNA,FOS,GAPDH,H3F3A/H3F3B,HINT1,HSPA1A/HSPA1B,HSPA8,LIMA1,LMNA,LRBA,MME,PHLDB2,PLS3,PPP1R1A,PPP1R1B,RAP1GAP,TJP2,TNS1,TUBB	 	
P1	 	BMP2	-0.717	growth factor	 	0.969	bias	0.302	-0.991	1.21E-05	ACP5,ADAMTS7,ALDH1A2,ASGR1,ATF6,BCL2L1,BMP2,BMP4,BSG,BTG3,CDK4,COL1A1,COL1A2,CRYM,CTSK,CXCL12,FGF2,FOS,FOSB,FST,GADD45B,HEY1,ID1,ID3,ID4,JUN,JUNB,KLF4,KLF9,LHCGR,MMP9,MYC,NOTCH1,NTRK3,PTGS2,RET,SMAD6,SMAD7,SOX9,SPARC,SPP1,TAGLN,TGM2,TIMP1,TMEM119,TOB1,VCAN,WDR5	BMP2,CEBPA,CEBPB,CTNNB1,ERK1/2,GATA4,HDAC1,JUN,NFKBIA,NFkB (complex),NOTCH1,RELA,RUNX2,SMAD1,SMAD3,SMAD4,SP1,STAT1,STAT3,Smad,TCF,TGFB1,TP53	
P1	 	wortmannin	 	chemical - kinase inhibitor	 	-1.497	 	-0.249	0.131	1.27E-05	ACACA,AGT,BCL2L1,CCL2,CCND2,CCND3,CD14,CDKN2B,CEBPD,CIDEA,CIDEC,COL1A1,COL1A2,COL3A1,CTGF,CXCL16,CXCL8,DDIT3,EGR1,ESR1,FOS,GAP43,HIF1A,HMOX1,IL6,IRS2,ITGAM,JUN,LEP,MAF,MCL1,MMP2,MMP9,MT2A,MYC,MYH11,NFKBIA,NR4A3,PTGS2,SELE,SOCS2,SOCS3,TFRC,TNFSF10,TPM1,TYMP,VCAM1	Ap1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,STAT3,TNF,wortmannin	
P1	 	SMARCB1	0.845	transcription regulator	 	-1.275	bias	0.288	-2.987	1.32E-05	ACAT1,AMPH,ARHGAP4,BNIP3L,BTG1,CDKN2C,COL18A1,COL1A1,COL1A2,COL5A2,CXCR4,CYP2C8,DSG2,ERBB2,ETS2,F11R,FASTK,FBP1,FOS,FZD7,GADD45A,GJB2,HBEGF,HEY1,HP,IFNAR2,LBP,MCM2,MYC,MYOM1,NEO1,PC,PELI1,PFKFB1,PLXNB2,PPP1R3C,PTMS,S100A1,SGCG,SMARCB1,SPARC,TMOD1,WASF3	CD44,ELK1,FOXO1,MYC,NFKB1,NFkB (complex),PPARG,RELA,RHOA,SMAD3,SMARCA4,SMARCB1,SP1,SP3,STAT1,STAT3,TP53,TP73	
P1	 	advanced glycation end-products	 	chemical - endogenous mammalian	 	-0.359	bias	0.251	-1.311	1.33E-05	ABCG1,BSG,CCL2,CLDN5,CTGF,CXCL12,CXCL8,DDAH2,FGF2,IL6,KLF2,MMP9,PFN1,PTGS2,SLIT2,SPP1,VCAM1	Akt,Ap1,CREB1,ERK1/2,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,STAT3,TP53,advanced glycation end-products,nitric oxide	
P1	 	ARNT	0.119	transcription regulator	 	-0.123	bias	0.396	-1.774	1.36E-05	ADAM17,ADM,ALDH3A1,ALDOA,ALDOC,ANGPTL4,ATP5G1,BHLHE41,CAV1,CCND2,CDK4,CTSD,CXCR4,CYP1B1,EDN1,EIF6,ENO1,EPAS1,G6PD,GAPDH,GZMH,HES6,HIF1A,IRS2,LEP,NDUFS3,NQO1,PCK2,RANGAP1,RGS5,S1PR1,SLC2A3,TFRC	AHR,ARNT,Ap1,CEBPB,CTNNB1,EGR1,EPO,ESR1,ESR2,FOXO3,HIF1A,JUN,MYC,NFKB1,NFkB (complex),PPARG,RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TP53,VHL	
P1	 	estrogen receptor	 	group	 	-1.015	 	-0.035	-0.773	1.37E-05	ABCG1,ADIPOQ,AXL,CAPG,CAV1,CCND2,CD24,CD59,CD68,CDH12,CDH5,COL12A1,COL4A5,COL5A1,COL6A1,COL6A2,COL7A1,CTGF,CXCL8,CXCR4,DCHS1,EDN1,EGR1,ERBB2,ETS1,F11R,FLNC,FOS,HBEGF,HRAS,HSPA1A/HSPA1B,IL6,ITGA3,JUN,KRT8,LDLR,LY6E,LYN,MAP1B,MMP9,MYC,NEDD9,PCDH7,PDGFD,PLAUR,POR,SMAD6,SPARC,TFF3,TGFBR2,TGFBR3,TIMP1,TIMP4,VEGFC,WNT5B	Ap1,EGF,EGR1,ERK,ESR1,FOS,JUN,MYC,NFKB1,NFkB (complex),RELA,SMAD3,SP1,SRC,STAT3,TP53,estrogen receptor	
P1	 	dithiothreitol	 	chemical reagent	 	-0.978	bias	0.283	-1.862	1.46E-05	ATF3,ATP2A2,CCNG2,DDIT3,ERBB2,GADD45A,HIF1A,HMOX1,HSPA5,MYC,PHLDA1,PTGES2,SELE	ATF2,CREB1,EGFR,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,SP1,STAT3,TP53,TP73,cisplatin,dithiothreitol	
P1	 	ADRB3	-0.116	g-protein coupled receptor	 	-0.770	bias	0.301	-1.598	1.51E-05	ADRB2,CCL2,CXCL12,EGR1,FOS,IL6,JUN,JUNB,LEP,UCP2	ADIPOQ,ADRB3,ATF2,CEBPB,Creb,EP300,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RNA polymerase II,SMAD3,STAT1,STAT3,cyclic AMP,isoproterenol	
P1	 	TSC2	0.671	other	 	-0.074	 	-0.225	1.044	1.52E-05	ATF3,ATF4,CCND2,CCND3,CRIP1,DDIT3,EGR1,EMP3,FAM107A,FAM129A,FOS,GAP43,GPNMB,HIF1A,HMOX1,HSPA5,IRS2,MCL1,MGP,NTRK3,PDK4,PHLPP1,PLP2,PRELP,SMPDL3A,TAGLN,THRSP,UCP2,ZFP36	AKT1,Akt,Ap1,CEBPA,CEBPB,FOXO1,HIF1A,JUN,MTOR,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,TSC2	
P1	 	SOD1	0.230	enzyme	 	-0.152	bias	-0.347	0.816	1.53E-05	ALDOC,APOE,ARL16,ASS1,ATF4,ATP1A2,AURKAIP1,BCL2L1,BMP4,C1QA,CASP4,CD14,CD36,CDH2,CDK4,COL1A1,COMT,CSF1R,CYB561,DCXR,ETS2,FOS,FTH1,GCLM,GPX3,GSTM1,GSTM3,GSTM5,HDDC3,HMOX1,HSPA4,HSPA8,IL6,JUN,JUNB,MMP9,MYOM1,PAWR,PRPH,PSMB5,SPP1,SQSTM1,STIP1,TFRC,TGFBR2,TNFAIP3,TNFRSF10B,VAPA,VCAM1	Ap1,BACH1,FOS,JUN,MAPK8,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SOD1,SP1,STAT3,TNF,TP53,TP73,nitric oxide	
P1	 	ERBB3	0.073	kinase	 	0.758	 	-0.063	1.062	1.60E-05	ACTA1,CCND2,CCNG2,COL1A1,COL6A1,CTSK,CXCL12,DUSP1,EGR1,EIF6,ERBB2,GZMH,HBEGF,HIF1A,HMOX1,HP,IER2,MATN2,PTGS2,SERPINA3,SFRP1,SLC4A7,SLK,SOCS3,SPARC,THBS1	ATF2,EGF,EGFR,ERBB2,ERBB3,ERBB4,JUN,MYC,NFKB1,NFkB (complex),NRG1,RELA,SMAD3,SP1,STAT,STAT3,STAT5A,STAT5B,STAT5a/b,TP53,estrogen receptor	
P1	 	Mek	 	group	 	-1.144	 	0.230	-2.492	1.62E-05	ACAT1,APOE,AXL,BCL2L1,BMF,CCND2,CCND3,COL1A2,CSF1R,CTGF,CXCL8,DUSP5,EGR1,EGR2,EGR3,ERBB2,ESR1,ETS1,ETV5,FOS,GAP43,GNL3,IER2,IL6,JUN,KDR,LEP,LRP8,MCL1,MMP9,MYC,NGF,NOX4,PHLDA1,PTGS2,RUNX1,SORL1,SPRY1,SPRY2,THBS1,UNG,VEGFC	Akt,CEBPA,CEBPB,HIF1A,JUN,MAP2K1,MYC,Mek,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53,TP73	
P1	 	ID3	-0.508	transcription regulator	 	-0.680	 	-0.080	-0.248	1.65E-05	ADGRG1,ADIPOQ,BCL2L1,CCND2,CCNG2,CDK20,CDKN2C,CXCL8,CXCR4,DUSP1,DUSP10,DUSP22,EGR2,ELOVL6,ETS2,FCER1G,G6PC3,GADD45B,GNL3,HIF1A,HOMER2,ID3,IL10RA,IL20RB,IL6,KLF6,LMO4,MAF,MAPK7,MMP2,MMP9,MYC,NOTCH1,NR4A3,PIK3C2B,PPAN,PTPN3,RAP1GAP,SELE,SMAD7,SOCS3,TGFBR3,TNFRSF4,TNFSF10,TOX2	ADIPOQ,Akt,EP300,HIF1A,ID3,IL6,JUN,MYOD1,NFKB1,NFkB (complex),PPARA,RELA,RNA polymerase II,SIRT1,SMARCA4,SP1,STAT1,STAT3,TCF3,TP53	
P1	 	salmonella minnesota R595 lipopolysaccharides	 	chemical - endogenous non-mammalian	Inhibited	-3.066	bias	0.501	 	1.66E-05	ATP6V1E1,AXL,CASP4,CCL2,CCL3L3,CCL8,CD86,CEBPD,CH25H,CXCL2,CXCL8,EGR1,ETS2,FOS,FOSB,GDF15,HLA-DRB4,IFIT2,IL6,ITPR2,JUN,JUNB,LPAR1,MCM2,MT1A,MT1X,NFKBIA,NFKBIZ,PTGS2,SLC7A2,SOCS3,TNFAIP3,TSC22D1,VCAM1	ERK1/2,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TLR4,TNF,TP53,salmonella minnesota R595 lipopolysaccharides	
P1	 	CD28	0.435	transmembrane receptor	 	-0.613	 	-0.244	1.371	1.73E-05	AHCYL1,AP1B1,BCL2L1,BIN1,BTG1,C2,CCL3,CCND2,CCND3,CD69,CD86,CDK4,CH25H,CLIP1,CS,CXCL2,CXCL8,CXCR4,CYC1,DUSP14,DUSP22,EGR2,FBL,FCER1G,FKBP2,FOS,FYN,GAPDH,GBP1,GTF2IRD1,GYS1,H19,HAVCR2,HAX1,HGS,HINT1,HIST2H2AA3/HIST2H2AA4,HOMER2,HSPA1A/HSPA1B,HSPA8,IGFBP6,IL10RA,IL6,JUN,KLF2,LSP1,MAF,MMP2,MYC,NCL,NFKBIA,NPIPA8 (includes others),ODC1,PCSK7,PTGER4,PTGS2,RPL6,SLC7A5,SNRPB,SOCS2,SOCS3,SRGN,SRPRB,STIM1,STOM,TFPI2,TFRC,THBS1,TNFAIP3,TNFSF10,TOB1,TSC22D1,TSTA3	Ap1,CD28,CD3,CREB1,IL2,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PI3K (complex),RELA,SP1,STAT1,STAT3,STAT6,TCR	
P1	 	LMNB1	0.019	other	Inhibited	-2.449	bias	-0.410	-1.445	1.73E-05	AEBP1,CRABP1,CRIP1,CXCL12,CYP51A1,DHCR7,GPC4,HBEGF,HMGCS1,LARGE1,LDLR,LMNA,MGP,MSMO1,PLIN2,RCN1,SERINC1,SLIT3,SQLE	 	
P1	 	ALDH1A2	-0.770	enzyme	 	-0.985	 	-0.178	-0.328	1.73E-05	ALDH1A1,ALDH1A3,ATF3,COL1A2,COL3A1,CTGF,CYR61,FGF2,IGFBP4,KIT,PCOLCE,SPARC,SPP1,TIMP1	ALDH1A2,ERK,JUN,NFkB (complex),RELA,SMAD3,SP1,STAT3,tretinoin	
P1	 	TCR	 	complex	 	-0.863	bias	0.331	-3.014	1.78E-05	ADM,BCL2L1,BIN1,BIRC3,BSG,CARD8,CCL3,CCL3L3,CCND3,CCR1,CD4,CD69,CTSB,CXCL8,CXCR4,CYTIP,DKC1,EBNA1BP2,EGR1,EGR2,ETV5,FLNA,FOS,FYN,GADD45B,GBP4,GNPDA1,HIF1A,HSPA5,ID3,IFIT2,IL6,ISG20,JUN,JUNB,KLF2,LPIN2,MAF,MAP3K8,MCL1,MYC,N4BP1,NFKBIA,NHP2,NME1,NRP1,ODC1,P2RX7,PA2G4,PDCD4,PDE3B,POMC,PRMT1,RUNX1,SDCBP,SIAH2,SLC2A3,SMAD7,SOCS2,SOCS3,SPP1,TNFAIP3,TNFRSF12A,TNFRSF4,TOB1,TSC22D1	CD28,CD3,CREB1,CREBBP,CSF2,IL1B,IL2,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,STAT1,STAT3,TCR	
P1	 	SLC13A1	-0.116	transporter	Inhibited	-2.646	 	-0.055	-2.357	1.82E-05	ACLY,AKR1C3,ALDH1A1,BYSL,C6,CD163,EDEM1,EEF1G,ELOVL6,G0S2,GALE,GFM1,GPAM,GPC6,HNMT,HSPA5,HSPA8,KLF9,MAD2L2,MVD,RPL8,SDF2L1,SPP1,SRPRA,STX6,TFG,TUBA1C,YARS	 	
P1	 	fatty acid	 	chemical - endogenous mammalian	 	0.577	bias	0.360	-1.140	1.82E-05	ACACA,ATF6,CD36,CIDEA,CXCL8,CYR61,DDIT3,GPAM,HMOX1,HSPA5,IL6,ITGAM,LDLR,LEPR,LPIN2,MMP9,NFKBIA,NR4A2,NR4A3,PLIN2,PTGS2,RBP4,S100A8,SLC27A1,THRSP,TNFRSF10B,UCP2,VCAM1	ADIPOQ,CREB1,FOS,FOXO1,Growth hormone,HIF1A,Insulin,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,Pkc(s),RELA,RXRA,STAT3,fatty acid,palmitic acid	
P1	 	Sn50 peptide	 	chemical toxicant	 	-0.790	bias	-0.398	0.991	1.93E-05	APOE,BCL2L1,BIRC3,CTGF,CXCL2,CXCL8,HMOX1,IL6,LIPG,MIF,MMP2,MMP9,MYC,PTGDS,PTGS2,SLC1A3,STC1,TNFRSF21,TNFSF10,TYMP,VCAM1	CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,RNA polymerase II,STAT3,Sn50 peptide,TERT,TNF	
P1	 	cyclic AMP	 	chemical - endogenous mammalian	 	-0.499	bias	0.321	-2.825	1.94E-05	ADRA2A,ANTXR1,AOC3,ARG2,ASS1,BMP2,CACNA1H,CCL2,CCND2,CD86,CDH2,CDK4,CEBPD,CRYM,CTGF,CYP11A1,DDIT3,EGR1,EGR2,ERBB2,FGF2,FOS,GAP43,GOT1,GTF3A,HBEGF,HIF1A,HSD17B11,IGFBP3,IGFBP4,IL6,JUN,JUNB,KDR,LEP,LHCGR,MME,MMP9,MYC,MYLK,NGF,NR4A2,ODC1,PFKFB1,PLA2G4A,POMC,PPP1R1B,PRNP,PTGS2,RARA,RBP4,SOCS3,SOX9,TF,THBD,THRSP,TIMP1,TNFRSF10B,TNFSF10	Ap1,CEBPA,CEBPB,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,STAT3,TNF,TP53,cyclic AMP	
P1	 	CBX5	0.558	transcription regulator	 	-0.640	bias	-0.501	 	2.01E-05	AHSA2,AKR1C3,ALDH3A1,AXIN2,CD24,CD68,CPA4,CYP1B1,ERAP2,GSTT1,HIST1H1C,HIST2H2AA3/HIST2H2AA4,ITGA7,KIT,MAL2,PODXL2,PPFIBP2,PRSS23,QPCT,QPRT,RARRES3,S100P,SERP2,SERPINA3,SLC2A10,SLC2A3,SLC7A8,SNTB1,SYTL2,TFF3,TIMP4,TM4SF1,TSPAN13	 	
P1	 	TWIST1	0.059	transcription regulator	 	0.000	 	0.192	-1.114	2.14E-05	ADAMTS1,ALCAM,ALDH1A1,C1QTNF1,C9orf3,CCDC3,CCL2,CDH2,COL1A1,COL6A1,CXCL12,CXCL8,DKK3,EFNB2,EGFL6,EMILIN1,EMP3,ESR1,ETS1,FBN2,FCGBP,FOS,GPC1,IGFBP4,IL6,KIT,LMNA,MME,MMP2,OLFML3,PAMR1,PCOLCE,PDZD2,SPP1,TF,TGFBR2,TNFRSF21,UNC5B,VCAN	Ap1,BCL2,CEBPB,Fgfr,JUN,MYC,NFKBIA,NFkB (complex),NOTCH1,NR3C1,RELA,SMAD3,SP1,STAT,STAT1,STAT3,TP53,TP73,TWIST1,cyclic AMP	
P1	 	EHF	-0.001	transcription regulator	 	-0.435	 	0.203	-1.455	2.17E-05	ANGPTL4,BMP4,CCL4L1/CCL4L2,CNFN,CRABP2,ERBB2,FCER1A,GLB1,HMOX1,IL6,KDR,KIT,LYN,MS4A2,PLAT,PLAUR,S100A8,S100A9,SAA1,SAA2,SAA4,SERPINA3,THBD,THY1,TIMP1,TNFRSF10B,VEGFC	 	
P1	 	Ins1	 	other	 	0.079	 	0.195	-1.429	2.17E-05	ACACA,ACADM,ADH1C,ADIPOQ,ADIPOR2,AGT,ALAD,ANGPTL4,AP2M1,ATP1A2,CCND3,CEBPD,CNN1,COL18A1,COL1A1,CRAT,CYB5A,DDIT3,DGAT2,ECI1,EDN1,EGR1,EGR2,EIF4EBP1,ELOVL6,ERCC1,ERP29,FGF2,FOS,G6PD,GAPDH,HMGCS1,HNRNPK,HP,HSD11B2,IGFBP3,IGFBP4,IL6,IMPDH2,IRS2,IVD,JUN,JUNB,LDLR,LEP,LIPE,MBP,MIF,MMP2,MYC,NDUFB9,NGF,ODC1,PIK3R2,PLAT,PLIN1,PLIN2,POMC,PTGS2,RGN,SLC27A1,SOCS2,SOCS3,SPARC,TF,THRSP,THY1,TIMP1,UQCRC1	CEBPB,D-glucose,FOXO1,HIF1A,IGF1,Ins1,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RNA polymerase II,RXRA,SMAD3,SP1,STAT3,TNF	
P1	 	mono-(2-ethylhexyl)phthalate	 	chemical toxicant	 	1.523	bias	0.439	-1.303	2.22E-05	ACADM,ACADVL,ACAT2,ACO2,ACSL4,ADIPOQ,ADIPOR2,ALDOC,ANGPTL4,ATP5D,BSCL2,CCND2,CD36,CDK4,CS,CYC1,CYP2C8,DDIT4,DGAT2,ENO1,FOS,G6PD,GAPDH,GFPT1,HADHA,HIPK2,IER2,IRS2,JUNB,KIF5B,LDLR,LIPE,N4BP1,NDUFA10,NDUFB9,NDUFS7,NDUFV1,PC,PDK4,PLIN2,TALDO1,UQCRC1	ACOX1,ADIPOQ,Ap1,FOXO1,JUN,NFKB1,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,mono-(2-ethylhexyl)phthalate	
P1	 	PTGES3	-0.085	enzyme	 	-0.547	bias	0.390	-1.560	2.23E-05	ABCC3,CTSD,HIF1A,MYC,NUPR1,PMP22,TM4SF1	AHR,CEBPB,ESR2,NFKB2,NFkB (complex),PGR,PTGES3,SMAD4,SP1,TP53,progesterone	
P1	 	bortezomib	 	chemical drug	 	1.562	 	0.072	1.070	2.34E-05	ALAS2,ALPL,ATF4,BCL2L1,BIRC3,BNIP3L,CAV1,CCND2,CDK4,CSF2RA,CXCL12,CXCL2,CXCL8,CXCR4,DDIT3,DNAJB2,DNAJB4,DNAJB6,ERN1,FANCE,FANCG,GADD45A,GADD45B,GDF15,GPNMB,HSPA1A/HSPA1B,HSPA5,HSPE1,IGFBP3,IL6,KIT,KLF9,LTBR,MCL1,MYC,NOX4,NSFL1C,ODC1,PSMA3,PSMA4,PSMB2,PSMB5,PSMB6,PSMB7,PSMD14,PSMD7,PTGS2,SAA1,SERPINA3,SRXN1,TNFRSF10B,UCHL1,VCAM1	Ap1,CEBPA,CEBPB,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53,bortezomib	
P1	 	salirasib	 	chemical drug	 	-0.139	bias	-0.386	1.516	2.38E-05	ADM,AK4,ALDOC,ATF3,ATF4,COL5A1,COL5A2,HIF1A,HRAS,MTOR,PFKFB3,PKM,PLAT,PLOD1,STC1,TGM2,TJP1,TJP2,VEGFC	Ap1,FOXO1,HIF1A,HRAS,JUN,MTOR,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,salirasib	
P1	 	aldosterone	 	chemical - endogenous mammalian	 	-0.709	bias	0.369	-2.670	2.42E-05	ACTA1,ADAMTS1,ADIPOQ,ADM,AGT,BMP2,CCL2,COL1A1,COL1A2,COL3A1,CTGF,CYBA,EDN1,ELN,ERGIC1,FAM65B,FKBP1A,FOS,IL6,KCNMA1,KDR,LOX,MMP2,NFKBIA,ORM1,PLAUR,PROCR,PTGS2,SGK1,SLC12A2,SLC9A1,SPP1,TPRG1,VCAM1	AGT,Ap1,Creb,ERK1/2,IL6,JUN,MYC,NFKBIA,NFkB (complex),NR3C1,NR3C2,Nfat (family),PPARG,RELA,Rock,SMAD3,SP1,SRF,STAT1,STAT3,aldosterone	
P1	 	HIC1	-0.058	transcription regulator	Inhibited	-2.009	 	-0.086	-1.629	2.57E-05	ADRB2,AHNAK2,ANO2,CA12,CDKN1C,CDO1,CXCL14,FST,ID4,KAZN,LRP8,MAP2K3,MAP2K5,MCAM,PLA2G4A,PLEC,SMPDL3A,SOX9,SPP1,SRGN,TNFAIP8	 	
P1	 	Pro-inflammatory Cytokine	 	group	 	0.130	bias	0.383	-1.182	2.57E-05	ADIPOR2,ADM,AKR1B1,APOE,ASS1,CD55,FGF2,GLUL,HMOX1,HP,HSPA5,IL6,ITGA1,LIPG,MMP9,S100A1,SDC4,SELE,SOCS3,TIMP1,VCAM1	Ap1,ESR1,ETS1,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,Pro-inflammatory Cytokine,RELA,STAT1,STAT3,TLR4,VEGFA	
P1	 	IL1	 	group	 	-1.032	bias	0.321	-3.484	2.58E-05	ABL1,ACACA,ADAM17,ADAMTS1,ADRB2,ALDH3A1,APOE,BMP2,C2,CBR3,CCL2,CCL3,CD55,CD59,CEBPD,CFB,COL1A1,CSF1R,CTSB,CXCL8,CYP27A1,DUSP1,EDN1,FOS,FST,FTH1,FZD5,H19,HIF1A,HMOX1,HP,IDO1,IL6,ITGAM,JUN,KIT,LDLR,LEP,LOX,LYZ,MAP2K3,MMP2,MMP9,MYC,NGF,ODC1,ORM1,PLA2G2A,PLA2G4A,POMC,PTGS2,RBP4,S100A9,SAA1,SAA2,SAA4,SDC4,SELE,SLC2A3,SOCS3,SOX9,SPARC,TGM2,THBD,THY1,TIMP1,TNFAIP3,TNFRSF4,TNFSF10,TYMP,VCAM1,VCAN	HIF1A,IL1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TNF	
P1	 	rosiglitazone	 	chemical drug	 	1.178	 	0.180	-0.375	2.68E-05	ABCC9,ABCG1,ACADM,ACADVL,ACO2,ACTA1,ADAMTS1,ADIPOQ,ADIPOR2,AGT,ANGPTL4,AOC3,APOC1,APOE,BIRC7,C1QA,C1QB,C1QC,CAT,CAV1,CCL2,CCL3L3,CD36,CD68,CD86,CIDEA,CIDEC,COL1A1,CS,CTGF,CXCL8,DGAT2,DHRS3,EDNRA,ELOVL3,ETS1,FAM3A,FOS,GAPDH,GBP1,GOT1,GPAM,H6PD,HMOX1,HP,HSPA5,HSPA9,IFIT2,IGFBP6,IL6,IRS2,ITGAM,KLF2,KLF4,LEP,LIPE,LOX,LPIN1,MAN1C1,MMP9,NGF,NOX4,NR1D1,PC,PDK4,PEA15,PECR,PLA2G15,PLIN1,PLIN2,PLTP,PTGS2,RARRES2,RBP4,S100A8,S100A9,SEMA3C,SGK1,SLC27A1,SLC9A1,SOCS3,SORBS1,THBS1,TIMP1,TSC22D1,UCP2	Ap1,FOXO1,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RNA polymerase II,RXRA,SREBF1,STAT3,TNF,palmitic acid,rosiglitazone	
P1	 	PRKCZ	0.072	kinase	 	-0.040	bias	0.301	-1.063	2.69E-05	COL1A2,CXCL8,ETS1,HIF1AN,HMOX1,JUN,LHCGR,MAPK7,MMP2,MMP9,MYC,NFKBIA,PSAT1,VCAM1	Akt,Ap1,CEBPB,ESR1,HIF1A,JUN,MAP2K1,NFATC2,NFKB1,NFKB2,NFkB (complex),Nfat (family),PRKCD,PRKCZ,RAC1,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	A23187	 	chemical reagent	 	-0.835	bias	0.312	-2.515	2.97E-05	ATP2A2,CD14,CD86,CXCL8,CYP11A1,DDIT3,DDIT4,DVL3,EGR1,EIF6,FGF2,FOS,FOSB,HSPA5,ID3,IL6,JUN,JUNB,MAP3K8,MYC,MYH1,NGF,ODC1,PTGS2,RCAN1,SDF2L1,SHC1,SYN1,THRSP,TNFSF10,TPO	A23187,CEBPB,CREB1,Ca2+,EGF,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	let-7a-5p (and other miRNAs w/seed GAGGUAG)	 	mature microrna	Inhibited	-2.939	bias	-0.501	 	2.97E-05	ADGRG1,ATP6V1F,BCL2L1,BSG,CAPG,CCND2,CDH2,COL1A1,COL1A2,COL3A1,COMMD9,GTPBP3,GYS1,HMGA1,HMOX1,HRAS,HYOU1,IFRD1,IGF2BP2,IPO4,ITGA1,MMP9,MRPS24,MYC,POLD2,PTGS2,RHOB,RTCA,SIGMAR1,SLC1A4,SLC25A1,SLC25A13,SLC38A1,SMOX,TAF9B,TAGLN,THBS1,TMEM2,TRMT1	IL6,NFkB (complex),RELA,SP1,STAT1,STAT3,let-7a-5p (and other miRNAs w/seed GAGGUAG)	
P1	 	VGLL3	0.470	other	 	0.000	bias	0.501	 	3.18E-05	ADM,COL12A1,COL1A1,COL1A2,GADD45B,SOX9,SPP1,THBS1	 	
P1	 	azetidyl-2-carboxylic acid	 	chemical reagent	Activated	2.180	bias	0.501	 	3.18E-05	ASNS,ATP2A2,DDIT3,EDEM1,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPA9	Ap1,NCK1,azetidyl-2-carboxylic acid	
P1	 	GW9662	 	chemical reagent	 	-1.409	 	-0.163	-0.586	3.24E-05	ACACA,ACLY,ADIPOQ,ANGPTL4,CAV1,CCL2,CD14,CD36,CD86,CTGF,FADS3,GDF15,GPAM,HSPA5,IL6,IRS2,KDR,KLF4,LOC102724788/PRODH,MID1IP1,NR1D1,PEA15,PLIN2,PTGS2,UCP2,VCAM1	Ap1,CAT,FOXO1,GW9662,JUN,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RXRA,SREBF1,STAT1,STAT3,TP53,fatty acid,rosiglitazone	
P1	 	SCAP	0.582	other	 	1.708	bias	0.483	-0.379	3.24E-05	ACACA,ACLY,ACSL4,ALDOC,CSAD,CYB5A,CYP51A1,DHCR7,ELOVL6,GPAM,HES6,LDLR,LSS,MSMO1,MVD,SQLE,TFF3,TM7SF2,TMEM97	ESR1,NFE2L2,NFkB (complex),PPARG,PPARGC1A,RELA,SCAP,SREBF1,SREBF2,STAT3,Srebp,TP53,USF1,cholesterol	
P1	 	iron	 	chemical - endogenous mammalian	 	1.466	 	0.064	1.230	3.24E-05	BMP6,CCND2,CCND3,CSNK2B,DDIT3,FTH1,GADD45A,GADD45B,HIF1A,HMOX1,ID1,IL6,MCOLN1,NDRG1,PCSK7,PPP1R15A,SLC39A8,TF,TFRC	AMPK,ATF6,Akt,Ap1,FOXO1,HIF1A,IL6,JUN,NFKBIA,NFkB (complex),PI3K (complex),PPARGC1A,RELA,SP1,STAT1,STAT3,TP53,dithiothreitol,iron	
P1	 	KDM5B	0.441	transcription regulator	 	1.136	 	-0.241	2.533	3.31E-05	CAV1,CTGF,CYB5A,DDIT3,DHCR24,DNAL4,EGR1,EPB41L1,ERBB2,ESR1,FHL1,FST,GADD45A,GCA,GJB2,HACD1,HSD17B8,ITGB1BP1,LIMCH1,MAPK8IP3,MCAM,MCM2,MT1E,MT1F,MT1X,NEDD9,NOL3,PDE3B,PIR,PLS3,PPOX,PSME3,SMOX,SOX9,SWAP70,TUBB2A	 	
P1	 	CBS/CBSL	1.756	enzyme	 	-1.407	 	-0.100	-1.110	3.32E-05	APOB,CCL2,CD69,CDO1,CLDN5,CSAD,GOT1,GOT2,UNG	 	
P1	 	SPTLC2	-0.520	enzyme	 	-1.782	bias	-0.368	-0.690	3.32E-05	ATF4,COL1A1,CTGF,DDIT3,HSPA5,MMP2,SPTLC2,THBS1,TIMP1	IL6,NFkB (complex),RELA,SP1,SPTLC2,STAT1,STAT3	
P1	 	CAV1	-0.517	transmembrane receptor	 	-1.040	 	0.097	-1.448	3.48E-05	ADAM17,ADGRG2,ADIPOQ,CAV1,CD14,CD276,CD36,CSF1R,EGR1,ESR1,FOS,HMOX1,HSPA8,ID1,IDO1,IL6,KDR,KRT8,LEP,NEDD4L,NOTCH1,NQO1,OSBPL7,PLA2G4A,RALA,SLC12A2,SLC20A1,SLC2A3,SLC7A2,ST6GALNAC4,THBS1,TJP1,TJP2,ZFP42	AKT1,CAV1,EP300,HMOX1,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	IGF1R	0.241	transmembrane receptor	 	-0.143	bias	0.301	-1.919	3.53E-05	ACADM,ACTA1,ATP5D,ATP5G1,BCL2L1,CD36,CD68,COL18A1,COL1A1,COL3A1,CTSD,CYP11A1,DDIT3,EDN1,ESR1,FLNC,FOS,HADHA,HIF1A,HSPA5,IGF2R,IGFBP3,IGFBP4,IL6,IRS2,ITGAM,LHCGR,MYC,MYCN,MYOM2,NDUFA9,NDUFB9,PECR,PHLDA2,PLAT,PTGS2,SCARA5,SLC16A2,TJP1,TPO,UQCRC1,VEGFC	CEBPA,CEBPB,CREB1,ERBB2,ERK1/2,FOS,FOXO1,Growth hormone,HIF1A,IGF1R,INSR,Ins1,Insulin,MYC,NFKBIA,NFkB (complex),PDX1,PPARA,PPARG,RELA,SMAD3,SP1,STAT3,STAT5a/b,TP53,estrogen receptor	
P1	 	LEPR	-0.834	transmembrane receptor	 	0.609	 	0.108	0.064	3.53E-05	ABCG1,ACACA,ADIPOQ,ANGPTL4,ANXA5,APOB,APOE,ATP2A2,BCL2L1,BTG1,CCL3L3,CD68,COL1A1,EIF4EBP1,EXOC4,FOS,GADD45B,GAP43,GPAM,IDO1,IGFBP3,IL6,INPPL1,IRS2,ITGAM,LDLR,LEP,LEPR,LGMN,MAP4K4,MBP,MMP2,PC,POMC,RPL7L1,SOCS2,SOCS3,STUB1,TGFBR2,TIMP1,TNFRSF4,UCP2	CEBPA,CEBPB,ERK1/2,FOS,IL1B,Ins1,JUN,LEP,LEPR,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,SMAD3,STAT3,TNF	
P1	 	15-E2-isoketal modified phosphatidylethanolamine	 	chemical reagent	 	0.243	bias	0.501	 	3.66E-05	CCL2,CXCL8,DDIT3,HSPA5,SELE,VCAM1	15-E2-isoketal modified phosphatidylethanolamine,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P1	 	MED28	0.104	other	 	1.791	bias	-0.501	 	3.66E-05	ACTG2,AEBP1,CNN2,CRIP1,MYH11,TAGLN	 	
P1	 	HNRNPK	0.711	transcription regulator	 	-1.624	 	0.000	-1.624	3.81E-05	AGT,COL12A1,CTGF,G6PD,IGSF10,LDLR,MYC,NRXN2,PRELP,PTGS2,SDPR,SLC47A1,UCP2	Ap1,CEBPA,CEBPB,ERK1/2,FOSL1,HNRNPK,JUN,MAP2K1/2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SP1,SRC,STAT3	
P1	 	dichlorovinylcysteine	 	chemical toxicant	Inhibited	-2.331	 	-0.116	-1.941	3.81E-05	ACAT1,CDK4,ENO1,GLOD4,HBEGF,HSPA9,IL6,ODC1,PKM,PRDX5,SORD,STIP1,TUFM	 	
P1	 	eicosapentenoic acid	 	chemical drug	 	0.164	 	-0.070	0.497	3.86E-05	ACADVL,ACAT1,ANGPTL4,APOE,CAT,CCL2,CD36,CD86,CEBPD,CIDEA,CSF1R,ELN,FOS,HMOX1,IMPA2,JUN,LDLR,LEP,MMP9,PDK4,PLIN2,PTGS2,SPI1,TGFBR2,THRSP	ATF2,Akt,Ap1,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SREBF1,STAT3,TP53,arachidonic acid,eicosapentenoic acid,fatty acid	
P1	 	Map3k7	 	kinase	 	-1.136	bias	0.432	-3.006	3.88E-05	BCL2L1,BMP4,CCL3L3,EDN1,EGR2,HBEGF,ID4,IFIT2,IL6,ISG20,JUN,MMP9,NFKBIZ,NGF,OSR1,PTGS2,RILPL1,S100A9,TSC22D1,VCAM1	Ap1,ERK,ERK1/2,ESR1,IL1B,JUN,Map3k7,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,SMAD3,STAT3	
P1	 	PTGS2	-2.630	enzyme	 	-1.993	bias	0.260	-3.527	3.91E-05	ANG,ANGPT1,BCL2L1,BIRC3,CCL2,CCL3L3,CD163,CD68,CDKN2C,CTSD,CTSK,CXCL12,CXCL14,CXCL8,CXCR4,CYP1B1,DUSP1,EDNRA,EGR1,ERBB2,FOS,IGFBP3,IL6,KDR,LEP,MCL1,MMP2,MMP9,MYC,NOP2,NR4A2,PLA2G4A,PTGER4,PTGS2,STC1,TEK,TGM2,TNFRSF10B,TNFSF10,VEGFC	Ap1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PTGS2,RELA,SP1,STAT1,STAT3,TNF,prostaglandin E2	
P1	 	TCF7L2	-0.043	transcription regulator	Activated	2.178	bias	0.437	-1.335	3.96E-05	ACOT4,ACSL3,ADIPOR2,AKR1C4,ALDH1A2,ALDH3A2,AQP9,AXIN2,BIN1,BMP4,CCND2,CD4,CREB5,CTGF,CYP2C8,CYP51A1,DHCR24,ENPP2,ENPP4,EPAS1,FBP1,FKBP1A,FRMD4A,FTH1,GCLM,GLUL,GSS,HIPK2,HSPA2,ICK,ID1,ID3,ID4,IDH1,IPO13,IRS2,KAT2B,KIF5B,KMT5A,LDLRAP1,MAP4K4,MAP7,MBP,MCAM,ME1,MTMR2,MYC,PARVB,PELI1,PI4KB,PKD1,PLAT,PLEKHH1,PPP1R14A,PPP1R16B,RNASE4,RTKN,SLC12A2,SMAD7,SRD5A1,STK39,SYTL2,TAF10,TMEM141,TMEM2,TNS1,TPRN	CTNNB1,FOXO1,Growth hormone,HDAC1,HIF1A,Insulin,JUN,NFkB (complex),PPARA,PPARG,STAT3,TCF,TCF7L2	
P1	 	N-nitro-L-arginine methyl ester	 	chemical drug	 	0.978	 	0.039	0.795	4.05E-05	ACTA1,ADIPOQ,ADM,AGT,ATF3,BCL2L1,CCL2,CD68,CD86,COL1A2,COL3A1,CTGF,CXCL2,CXCL8,CYBA,HMOX1,IL6,MAP1B,MMP9,NFKBIA,PDK4,PERP,PTGS2,SELE,TIMP1,VCAM1	Ap1,HIF1A,IL6,JUN,MYC,N-nitro-L-arginine methyl ester,NFKB1,NFKB2,NFKBIA,NFkB (complex),NOS2,P38 MAPK,RELA,SP1,STAT1,STAT3,Tnf (family)	
P1	 	vancomycin	 	biologic drug	 	1.965	bias	0.303	0.437	4.05E-05	ADAMTS1,ASNS,BIRC3,CAPN6,CAT,CD14,CXCL2,EFEMP2,EMP3,FMO2,GPNMB,GPX8,GSTM3,HMOX1,IER3,LXN,MYC,NOX4,PSMB10,RCN1,RTN4,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	bardoxolone	 	chemical drug	Activated	3.231	 	0.167	2.612	4.09E-05	CEBPG,DDIT3,EPHX1,FTH1,GCLM,GSR,HMOX1,HSPA9,NFKBIA,NQO1,NQO2,SQSTM1,TUFM,TXNRD1	 	
P1	 	INS	-0.007	other	 	0.422	 	0.055	0.139	4.15E-05	ACACA,ACADM,ACADVL,ACLY,ALDH3A2,ANO1,AQP9,ASPH,BCL2L1,CAT,CBS/CBSL,CD36,CIDEA,CIDEC,CTGF,DDIT3,EGR1,EIF4EBP1,ELK1,FADS3,FOS,FOSB,HIF1A,HSPA5,IGFBP3,IGFBP4,IRS2,JUN,JUNB,LEP,NDUFV1,PLIN2,SMPD1,TRIB3	ATF4,CEBPB,D-glucose,E2F1,EGR1,ERK1/2,FOXO1,Growth hormone,HIF1A,IGF1,INS,Insulin,JUN,MYC,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SIRT1,SMAD3,SP1,STAT3	
P1	 	PML	-0.135	transcription regulator	 	-1.235	 	-0.057	-0.919	4.25E-05	ACACA,ACADM,ACSL4,ADIPOQ,APOE,CAT,CDKN2B,CIAPIN1,DNAJB4,DNAJB6,GADD45A,GCLM,GPAM,HMOX1,LDLR,LEP,LIPE,LYZ,MAF,NDRG1,NQO1,NSFL1C,PCBP2,PDK4,RRAS2,RSU1,SQSTM1,STIP1,TNFAIP3,TXN,TXNRD1,UBE2M,UCP2	AMPK,Ap1,CREBBP,EP300,FOXO1,HIF1A,IL1,NFKB1,NFKBIA,NFkB (complex),NR4A1,PML,PPARGC1A,RELA,RXRA,SP1,STAT1,STAT3,TP53,reactive oxygen species	
P1	 	FLT1	-0.017	kinase	Inhibited	-2.558	 	0.172	-3.365	4.25E-05	AHCY,BNIP3L,CANX,CAPN2,DDX3X,DHCR24,EPAS1,FLNA,FOS,G3BP2,HK1,HMOX1,LIMS1,NOTCH1,PREB,RNF125,SCRN1,SURF1,TGFBR2,THBS1,TNFRSF10B,TNIP1,VPS4A	Akt,Ap1,CEBPA,CEBPB,CTNNB1,ETS1,FLT1,HDAC1,HIF1A,JUN,NFkB (complex),NOTCH1,PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,VEGFA,Vegf	
P1	 	ZNF217	-0.496	transcription regulator	 	1.546	bias	-0.478	3.453	4.25E-05	ADM,CCL2,CDKN2B,COL8A1,CREB5,IGFBP3,ITM2A,LMO3,MAP2K5,MPZL2,MYC,MYCN,NLGN1,NMNAT2,PKP2,PLAT,RCAN1,RGS20,SOCS2,ST3GAL6,WNT5B,ZHX2,ZNF616	 	
P1	 	SPI1	0.637	transcription regulator	Activated	3.657	 	0.186	2.647	4.31E-05	BTK,C1QC,CCND2,CD14,CD209,CD68,CSF1R,CSF2RA,CSF3R,CTSK,DAB2,EBF1,ELANE,EPB41L2,ETS2,FCER1A,FCER1G,FCGRT,FOS,FTH1,HMBS,HSPA8,ID3,IMP4,ITGAM,JUN,KIT,KLF4,LYZ,MBP,MCL1,MME,MMP2,MT1A,MT1E,MT1F,MT1G,MT1X,MT2A,MYC,NCF2,NOL6,PSMB10,PTGS2,SNU13,SPI1,SPP1,TNFRSF14	Ap1,CSF1R,CTNNB1,FOS,HDAC3,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,SPI1,STAT,STAT1,STAT3,STAT5a/b,TNF	
P1	 	AGN194204	 	chemical drug	 	0.643	bias	0.443	-1.848	4.33E-05	ACAT2,AEBP2,ATF3,BNIP3L,BZW2,CAMK2D,CCL3L3,CCNG2,CDKN2C,CRABP2,CST3,CYB5A,CYP51A1,DHCR7,DUSP1,ELOVL3,EMP1,EMP3,GADD45A,GAPDH,GNAI1,H2AFZ,HIST1H1C,IRS2,ITM2A,KLF6,LMNA,LSS,MMP9,MYC,NSMAF,PDCD4,PHLDA1,PLIN2,PRNP,RAMP3,SCIN,SLC3A2,SPP1,STIM1,TIMP1	AGN194204,CTNNB1,HDAC1,JUN,NFkB (complex),STAT3,TCF	
P1	 	norepinephrine	 	chemical - endogenous mammalian	Inhibited	-2.125	bias	0.291	-3.869	4.33E-05	ACTA1,ADRA1B,ATP2A2,CTGF,CXCL8,CXCR4,DUSP1,EDN1,EGR1,ELOVL3,ELOVL6,FCER1A,FGF2,FOS,FST,FTH1,GDF15,GRK5,HMOX1,ID1,IL6,IRS2,LEP,LRRN3,MCAM,MMP2,MMP9,NFKBIA,NGF,NR4A3,PADI4,PDE8B,POMC,PTGS2,RBP4,SGK1,SMAD7,TFRC,THRSP,TINAGL1,UBE2I	ERK1/2,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,norepinephrine	
P1	 	IPMK	0.018	kinase	 	-0.544	bias	0.501	 	4.34E-05	ABHD12,CAPNS1,CYR61,FLNA,FLNC,FOS,FOSB,JUN,JUNB,PFN1,PMP22	Ap1,CREB1,Ca2+,ELK1,ESR2,FOS,IPMK,JUN,MKL1,MKL2,NFkB (complex),SP1,SRF,STAT3,TP53	
P1	 	NOX4	-1.661	enzyme	 	-0.308	bias	0.343	-1.356	4.34E-05	AGT,BCL2L1,BMF,CCL2,CXCL8,EPAS1,HIF1A,KIT,MCL1,MMP2,NOX4	Akt,Ap1,CEBPA,CEBPB,HIF1A,JUN,Jnk,NFKB1,NFkB (complex),NOX4,RELA,SP1,SRC,STAT1,STAT3,TP53,hydrogen peroxide	
P1	 	cis-urocanic acid	 	chemical drug	 	-1.618	bias	0.501	 	4.34E-05	ADAMTS1,CD55,CXCL8,GADD45B,GLRX,HSPA1A/HSPA1B,IGFBP3,IL6,NCF2,PTGS2,TNFAIP3	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,cis-urocanic acid,prostaglandin E2	
P1	 	kainic acid	 	chemical toxicant	 	-0.910	bias	0.341	-2.881	4.46E-05	APOE,APOLD1,ATF3,ATF4,BCL2L1,BTG2,CDK4,CIART,CSF1R,CSRNP1,DUSP1,EGR1,EGR2,FGF2,FOS,FOSB,GADD45B,GAP43,HBEGF,HDC,HYOU1,JUN,JUNB,KDR,MMP9,NGF,NR4A2,ODC1,PPP1R15A,PTGS2,RELN,RET,SPP1,TIMP1,TIPARP,TJP1,TMEM158	CEBPB,CREB1,CREBBP,CREM,Ca2+,Creb,FOS,IL1B,JUN,MAPK1,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,STAT3,TP53,kainic acid	
P1	 	hydrocortisone	 	chemical - endogenous mammalian	 	-0.396	 	0.052	-0.694	4.80E-05	ADM,CCL2,CCND2,CCND3,CD163,CD86,CEBPD,CTGF,CXCL8,CXCR4,ERP29,FGF2,GADD45B,GAP43,GBP1,GLUL,H6PD,IGF2R,IGFBP3,IGFBP4,IGFBP6,IL6,ITGAM,NARFL,NFKBIA,NUSAP1,PTGS2,S100A8,SELE,SEMA6A,SMO,STC2,STX1A,TNFAIP3,TUBB	AGT,Ap1,CEBPB,FOS,HIF1A,IGF1,IL6,JUN,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,SP1,STAT1,STAT3,dexamethasone,hydrocortisone	
P1	 	maslinic acid	 	chemical - endogenous non-mammalian	 	-1.000	bias	-0.398	0.193	4.84E-05	ACTN1,ADAM17,BCL2L1,CCND2,CDK4,CDO1,DOCK1,ETS1,FBXW5,FZD7,GSK3B,IRAK1,ITGA3,ITPR2,JUNB,NCL,PLAUR,PRKCE,PTGS2,PTPA,SHC1,SLC1A3,SORBS1,SOS1,THBS1	Akt,ERK,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TP53,maslinic acid	
P1	 	beta-naphthoflavone	 	chemical toxicant	Activated	2.623	 	0.226	1.797	4.87E-05	ABCC3,ALAS2,APOE,CYP1B1,CYP4B1,CYR61,FOS,FTH1,GCLM,GSTM1,GSTM5,LBP,MAFG,ME1,NQO1,SAA1,SLCO2B1,SOCS2	9,10-dimethyl-1,2-benzanthracene,AHR,APOE,Ap1,BACH1,CEBPB,CTNNB1,NFE2L2,NFKB1,NFkB (complex),RELA,SMAD4,SP1,STAT1,STAT3,TP53,benzo(a)pyrene,beta-naphthoflavone	
P1	 	LEP	-4.224	growth factor	 	-0.871	 	0.187	-2.413	5.02E-05	ABCC3,ACACA,ACADM,ACADVL,ACAT1,ACLY,ADIPOQ,ANGPTL4,AQP9,ASS1,ATP2A2,BCL2L1,CA3,CAV1,CCL2,CCL3L3,CD14,CD36,CD68,CEL,CIDEA,COL1A1,COL3A1,CYB5A,CYBA,CYP11A1,CYP2C8,CYR61,EDN1,EGR1,EGR2,ELOVL6,ERBB2,ESR1,FAAH,FOS,GADD45A,GAP43,GAPDH,GOT2,GPAM,GSK3B,HEY2,HSPA5,IDH1,IGFBP3,IL6,IRS2,ITGAM,JUN,JUNB,KIF3B,LDLR,LEP,LEPR,LIPE,MBP,MCL1,MMP2,MSMO1,MYC,NCF2,NOTCH1,OPLAH,ORM1,PLAT,PLIN1,PLIN2,POMC,PTGS2,SELE,SLC27A1,SMPD1,SOCS3,SORD,SPARC,SPI1,SPP1,SYN1,THBS1,THRSP,TIMP1,TMED9,TNFSF10,UCP2,VCAM1,ZFP36	CEBPA,CEBPB,FOS,FOXO1,Growth hormone,HIF1A,IGF1,IL6,Ins1,Insulin,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TNF	
P1	 	Sb202190	 	chemical - kinase inhibitor	Activated	2.459	bias	-0.340	4.320	5.08E-05	ANGPTL4,CCL2,CCL3,CCND2,CCND3,CD55,CD86,COL1A1,CTGF,CXCL8,EGR1,FCER2,FOS,HIF1A,HMOX1,HSPA5,IL6,JUNB,LDLR,MAPKAP1,MMP2,MMP9,PCBP2,PHLDA1,PLA2G2A,PLA2G4A,PTGS2,RHOB,S100A8,SGK1,SPI1,TNFRSF10B,TYMP	CEBPA,CEBPB,ERK1/2,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,Sb202190,TNF,TP53	
P1	 	bisphenol A	 	chemical - endogenous non-mammalian	 	-0.018	bias	0.350	-1.750	5.18E-05	ADIPOQ,ALDH5A1,APEH,APOB,ATP6AP1,CCL2,CDK4,CTGF,CTSD,CXCL12,DLG4,EGR1,ENO1,ESR1,FOS,HSPA1A/HSPA1B,KDR,LAMP2,LBP,LEP,LHCGR,MAOA,MMP9,NR4A2,NR4A3,PEBP1,PKM,PTGS2,RPN2,SLC1A5,SRD5A1,SYN1	AR,Akt,CEBPA,CEBPB,Creb,ERK1/2,ESR1,ESR2,HIF1A,JUN,NFKB2,NFKBIA,NFkB (complex),PGR,RELA,SMAD3,STAT1,STAT3,TP53,bisphenol A,progesterone,testosterone	
P1	 	RET	1.998	kinase	 	-0.866	bias	0.327	-2.293	5.26E-05	ATF4,CCL2,CLDN5,COL1A1,COL1A2,CTSB,CXCL12,CXCL8,CXCR4,DNAJB2,EGR1,FKBP4,FOS,HSPA1A/HSPA1B,HSPA8,HSPA9,IL6,LOX,MAF,MAPKAPK2,MMP9,PLAUR,PRNP,REEP6,RET,RTN4,S100A9,SCARA3,STC1,STIP1,STUB1	CEBPA,CEBPB,CTNNB1,HIF1A,HRAS,ITGB1,MMP9,NFKB1,NFKB2,NFKBIA,NFkB (complex),NOTCH1,RELA,RET,SP1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	losartan potassium	 	chemical drug	 	0.138	bias	-0.309	1.733	5.31E-05	AGT,ANGPT1,ATF4,ATP2A2,CAV1,CD36,COL1A1,COL3A1,CST3,CTGF,CXCL8,EDN1,EDNRA,EGR1,FOS,GRK5,HSPA5,IL6,ITPR2,MMP2,MMP9,NOX4,PTGS2,SOCS3,SPP1,TEK,TGFBR2,TIMP1,UCP2,VCAM1	AGT,Akt,Ap1,ERK1/2,HIF1A,IL6,JUN,Jnk,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53,losartan potassium	
P1	 	bleomycin	 	chemical drug	 	0.596	bias	0.467	-2.162	5.31E-05	ANGPT1,BCL2L1,CCL2,CCL3L3,CCR1,CD86,COL1A1,COL1A2,COL3A1,CTGF,CTSD,CTSK,CXCL2,CXCR4,ELN,FRZB,HBEGF,HEY1,ID1,IL6,ITGA1,MIF,MMP2,MMP9,MYC,PLA2G15,PLAT,PRPF19,PTTG1,SDC4,SFRP1,SOCS2,SPP1,STOM,THBS4,TIMP1,TIMP4,TINAGL1,TNFRSF10B,VHL	Ap1,HGF,IFNG,IL6,JUN,NFKB1,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,Tgf beta,bleomycin	
P1	 	RCAN1	0.507	transcription regulator	Activated	2.133	 	-0.182	2.685	5.32E-05	ACTA1,CD36,CDK4,CXCL8,FOS,GSK3B,IL6,MYH1,PTGS2,RCAN1,SELE,VCAM1	ATF2,IL1B,JUN,MAP3K7,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RCAN1,RELA,STAT3,TAB1,TP53	
P1	 	diazoxide	 	chemical drug	 	0.389	 	-0.167	0.941	5.32E-05	ABCC9,ACACA,BCL2L1,EGR1,HYOU1,KCNJ8,LEP,MYC,ODC1,POMC,SLC39A8,UCP2	CEBPA,CEBPB,D-glucose,FOS,FOXO1,FOXO3,Growth hormone,HIF1A,INS,Ins1,Insulin,JUN,LEP,MYC,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,SP1,STAT3,diazoxide	
P1	 	PROC	0.079	peptidase	 	-1.197	 	-0.153	-0.596	5.34E-05	AGT,ANGPT1,CCL2,CXCL2,CXCL8,IL6,MMP2,MMP9,PLA2G2A,PROCR,SELE,TEK,THBD,THBS1,TJP1,TNFAIP3,VCAM1	Ap1,ESR1,F2R,IL1B,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PROC,RELA,SP1,STAT3,TNF	
P1	 	BACH1	-0.148	transcription regulator	Inhibited	-2.555	bias	-0.270	-1.865	5.55E-05	CXCR4,FTH1,GCLM,HMOX1,ME1,NQO1,SPP1,SQSTM1,TTC23,VTRNA1-1	BACH1,NFE2L2,NFKB1,NFkB (complex),RELA	
P1	 	DMP1	0.057	other	Inhibited	-2.354	 	-0.215	-1.501	5.75E-05	ADAMTSL2,ALPL,BMP2,BZW2,C1QB,CDH5,CORO2B,CXCL8,F13A1,IL6,LIPG,SLC6A9,SMAD6,SPP1,STAB1,TMEM267	DMP1,GATA4,NOTCH1,RUNX2,SMAD1,SP1,Smad	
P1	 	PDGFB	0.399	growth factor	 	-0.532	bias	0.270	-1.626	5.84E-05	ADAMTS7,CCL3,CNN1,COL1A1,COL1A2,CXCL8,EGR1,FOS,IL6,KLF2,MMP2,MMP9,MYC,PHLDA1,PTGS2,RGS5,SPP1,THBS1,TIMP1	Ap1,CTNNB1,ELK1,ERK1/2,FOS,HIF1A,ITGB1,JUN,Jnk,MAPK3,NFKBIA,NFkB (complex),PDGFB,PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b	
P1	 	DACH1	-0.373	transcription regulator	Activated	2.900	 	-0.215	3.722	6.02E-05	BMP4,CXCL8,EGR1,FGF2,FOS,ID1,IER2,IGFBP3,IL6,JUN,KLF4,PTGS2,RELN,STC2,TNFAIP3	Ap1,DACH1,ESR1,IL6,JUN,NFATC2,NFkB (complex),Nfat (family),RELA,SP1,STAT1,STAT3	
P1	 	IRS1	0.133	enzyme	 	-0.945	 	0.218	-1.608	6.05E-05	ACACA,ADIPOQ,BMP6,CDKN2B,CDKN2C,CEBPD,CIDEA,COL3A1,COL6A1,COL6A3,COL7A1,CRABP2,DBNL,DDIT3,DVL2,EFNB2,EGR1,FHL1,FMO1,FOS,IGFBP4,IRS2,LDLR,LEP,MYC,NRP1,PTPRF,RHOU,SFRP2,SPP1,THRA,TRIB3,UCP2	AKT1,ATF4,CEBPA,CEBPB,E2F1,EGR1,FOS,FOXO1,FOXO3,Growth hormone,HIF1A,INS,IRS1,Ins1,Insulin,NFKB1,NFkB (complex),PPARA,PPARG,SIRT1,SP1,STAT1,TP53	
P1	 	WNT1	-0.001	cytokine	 	-0.020	bias	0.342	-1.630	6.05E-05	APCDD1,AXIN2,BMP4,CCDC80,CCND2,CCND3,DNAJC1,DUS2,EGR1,EIF3C,EIF4EBP1,EIF4EBP2,ENPP2,ETS2,FOS,FZD2,GRN,ISLR,JUN,JUNB,KIT,LY6E,MYC,PDCD4,PTGS2,RELN,RHOU,RNASE1,SEMA3C,SPP1,TJP1,TLE1,VEGFC	Akt,CTNNB1,ERBB2,HDAC1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TCF,TP53,TP73,WNT1,estrogen receptor	
P1	 	glutamine	 	chemical - endogenous mammalian	 	-1.175	 	-0.107	-0.743	6.06E-05	AARS,ASNS,ASS1,ATF4,ATF5,ATF6,BSG,CARS,CXCL8,DDIT3,DUSP1,FOS,GADD45A,GCDH,HK1,HSPA1A/HSPA1B,HSPA5,IDH1,IL6,JUNB,NFKBIA,PCK2,PTGS2,PYCR1,WARS	ATF4,Ap1,CREB1,DDIT3,HIF1A,IGF2,JUN,Jnk,NFE2L2,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,RNA polymerase II,SP1,STAT3,glutamine	
P1	 	mercuric chloride	 	chemical toxicant	 	0.224	 	0.100	-0.017	6.10E-05	CDH2,DDIT3,GADD45A,GSR,GSTM1,HBEGF,HMOX1,HP,HSPA1A/HSPA1B,HSPA9,JUN,JUNB,SPP1,TXN	Ap1,CEBPA,CEBPB,ESR1,ESR2,FOS,IL6,JUN,MAPK8,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TP53,beta-estradiol,mercuric chloride	
P1	 	CALCA	0.087	other	 	-0.896	 	0.178	-1.802	6.39E-05	AHNAK,CCL2,CD86,COL3A1,CTSK,CXCL8,CXCR4,CYBA,EDN1,ESAM,FOS,IL6,JUNB,KDR,LIMA1,LMNA,LRBA,MME,ODC1,PHLDB2,POMC,PPP1R1A,PPP1R1B,RAP1GAP,SPI1,TJP2,TNS1	CALCA,CEBPB,CREB1,Ca2+,EDN1,ERK1/2,HIF1A,IFNG,JUN,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	5-hydroxytryptamine	 	chemical - endogenous mammalian	 	-0.169	bias	0.390	-1.918	6.39E-05	ALDH1A2,ASIC1,CCL2,CTGF,CXCL8,CYP1B1,EGR1,FGF2,FOS,GTF3A,HBEGF,HIF1A,IL6,MYC,NCF2,NUCB2,POMC,PTGS2,STAB1,THBS1,UCP2,VCAM1	5-hydroxytryptamine,CEBPB,ERK,ERK1/2,FOS,IL6,JAK2,JUN,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,cyclic AMP	
P1	 	SREBF2	0.061	transcription regulator	Activated	2.814	bias	0.386	1.122	6.39E-05	ACACA,ACLY,ALDOC,CYB5A,CYP51A1,DHCR7,ELOVL6,G6PD,HES6,HMGCS1,IDH1,IRS2,LDLR,LSS,MSMO1,MVD,PLIN2,SQLE,TFF3,THRSP,TM7SF2,TMEM97	CEBPA,CEBPB,ESR1,FOS,FOXO1,Ins1,MYC,NFE2L2,NFkB (complex),Nr1h,PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,SREBF2,STAT3,TP53,TP73,USF1,cholesterol	
P1	 	oleic acid	 	chemical - endogenous mammalian	 	0.743	 	0.156	-0.032	6.45E-05	ACACA,ACADM,APOB,APOE,AQP9,ATF4,ATF6,CD36,DDIT3,DGAT2,DUSP1,EDN1,FOS,GADD45A,GADD45B,GAPDH,HSPA5,IGFBP3,IL6,LDLR,NFKBIA,PDK4,PLIN2,PTGS2,SELE,THRSP,UCP2,VCAM1	D-glucose,FOXO1,Growth hormone,HIF1A,Insulin,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,fatty acid,oleic acid,palmitic acid	
P1	 	L-methionine	 	chemical - endogenous mammalian	 	0.697	 	-0.046	0.830	6.59E-05	CDKN2C,CXCL2,DDIT3,ETS2,GADD45B,GNA11,HSPA5,IGFBP4,MGMT,NFKBIA,NUSAP1,PCK2,PIN1,PLAT,RHOB,SMAD7,SPHK2,SPP1	Ap1,CREB1,CTNNB1,FOXO1,FOXO3,HMGA1,IRS1,JUN,L-methionine,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,SPP1,STAT3	
P1	 	MXI1	-0.095	transcription regulator	 	-1.931	bias	-0.501	 	6.69E-05	IARS,IMPDH2,LARS,MTHFD2,MYC,MYCN,ODC1,SLC1A4,SLC7A1	MAX,MXI1,MYCN	
P1	 	Pka	 	complex	 	0.205	bias	0.257	-1.196	6.71E-05	ANTXR1,APOE,CAV1,CCND3,CD14,CDH2,CTGF,CYP11A1,CYP51A1,DDIT3,DUSP1,EDN1,EGR1,FOS,HMOX1,IFI27,IL6,JUN,JUNB,KLF6,LDLR,LEP,LHCGR,LIPE,NGF,NR4A2,NR4A3,POMC,PPP1R1B,PTGS2,RUNX1,SGK1,SLC1A3,SOX9,SPI1	Ap1,CEBPB,CREB1,CREBBP,CREM,CTNNB1,Creb,EP300,JUN,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARG,Pka,RELA,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	acetaminophen	 	chemical drug	 	1.305	 	0.189	0.236	6.87E-05	ABCC1,ABCC3,ACADM,AK4,BTG2,CA3,CAST,CAT,CCL3L3,CCR1,CES1,CXCL2,DDIT3,GADD45A,GLUL,GSR,HIF1A,HMGCS1,HMOX1,HSPA5,IFRD1,IGFBP3,IL6,JUN,KDR,MCL1,ME1,MYC,NQO1,ODC1,ORM1,PLAUR,PTGS2,SOCS3,TF,TUBB,TXN,VCAM1	Ap1,BACH1,IL1B,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,acetaminophen,hydrogen peroxide	
P1	 	IL17A	0.030	cytokine	 	-1.986	bias	0.358	-4.293	6.88E-05	APBA3,CCL2,CD14,CD163,CD68,CEBPD,COL1A1,CTGF,CTSK,CXCL12,CXCL2,CXCL8,CYR61,CYTH3,FGF2,FMO1,FOS,GADD45A,GUSB,HBEGF,IL6,ITPR2,JUN,KLF2,LEP,LOX,MMP2,MMP9,MYC,NFKBIZ,NRP1,PLXNB2,PTGFR,PTGS2,RGS16,S100A8,SELE,SOCS3,TGFBR2,THBD,TIMP1,TIMP4,TNFAIP3,TYMP,VCAM1,VEGFC,VEGFD	IFNG,IL10,IL17A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF	
P1	 	androgen	 	chemical drug	 	-0.218	 	-0.011	-0.168	7.16E-05	AES,AKR1C3,AXIN1,AXIN2,BMP4,BMP6,BTG2,CA12,CA3,CCND3,COL12A1,CTSB,CXCR4,DHCR24,DNM1L,ETS1,FGF2,FLNA,FOS,ITGAM,JUN,MMP23B,MMP9,MYC,NFKBIA,PTGS2,PTPRA,PTPRK,RET,RUNX1,SDC4,SFRP2,SOX9,STIM1,TACC2,TNFAIP8,TRPM8,TSC2,VAV3,VEGFC	Ap1,CREB1,ELK1,ERK,FOS,JUN,MAPK3,NFKB1,NFkB (complex),PI3K (complex),Pkc(s),RELA,SMAD3,SP1,SRC,STAT3,androgen	
P1	 	PLA2G4A	-0.513	enzyme	 	0.420	bias	0.424	-0.753	7.30E-05	ANXA5,CXCL8,GSTM5,IL6,MYC,PLA2G2A,PLA2G5,PTGS2	ATF2,IFNG,JUN,NFKBIA,NFkB (complex),P38 MAPK,PLA2G2A,PLA2G4A,PPARA,PPARG,RELA,SP1,SREBF1,STAT1,STAT3,arachidonic acid,prostaglandin E2	
P1	 	PTGER1	0.315	g-protein coupled receptor	 	-0.605	 	0.228	-1.198	7.30E-05	ANGPTL4,CXCL8,EGR2,FOS,IL6,POMC,PTGS2,VEGFC	AGT,Ap1,ERBB2,IFNG,JUN,MYC,NFKBIA,NFkB (complex),PPARG,PTGER1,PTGS2,RELA,SMAD3,SP1,STAT1,STAT3,TP53,estrogen receptor,prostaglandin E2	
P1	 	NfkB-RelA	 	complex	 	-0.941	bias	0.501	 	7.30E-05	AGT,BCL2L1,CCL13,CCL2,CCL3,CXCL8,IL6,NFKBIA,PTGS2,SELE,VCAM1	 	
P1	 	PAF1	-0.193	other	Inhibited	-2.025	bias	0.501	 	7.33E-05	BAMBI,BIRC3,CCL3,CCL3L1,CCL3L3,CCL4L1/CCL4L2,FAM46A,HOXA9,IDO1,ISG20,KLF4,LRRN3,NFKBIZ,PLAUR,SDC4,SERTAD1,ZFP36	 	
P1	 	MAP4K4	0.568	kinase	Inhibited	-4.849	bias	-0.501	 	7.59E-05	ACACA,ACADVL,ACLY,ACO2,AGL,ALDH3B1,ALDH4A1,ATP6V0A2,BCAT2,CYC1,DHRS4,EIF4E2,GCDH,GLUL,GOT1,GYS1,H6PD,HADHA,HMGCL,IVD,NDUFAB1,NDUFS8,NDUFV1,PDXP,PEX16,PIGO,PTDSS2,PTS,RPS6KB2,ST3GAL4,UQCRC1	 	
P1	 	COL18A1	0.666	other	 	1.192	bias	-0.389	3.153	7.72E-05	ANTXR1,BCL2L1,CCL2,CDH5,CDKN2C,DDIT4,EDN1,EFNB2,ETS1,FGF2,FOS,HIF1A,HIF1AN,ID1,ID3,IL6,JUN,JUNB,KDR,MCL1,MMP2,MYC,NRP1,PTGS2,THBS1,TNFRSF21	Akt,Ap1,COL18A1,ERK,ETS1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,SRC,STAT3,TP53,VEGFA	
P1	 	Nfat (family)	 	group	 	-0.555	bias	0.501	 	7.72E-05	ACP5,CCL2,CCL3,CCL3L3,CTSK,CXCL8,CYR61,DAAM1,DHRS9,DKK3,EGR2,FCER2,FHL1,HBEGF,KLF6,NCOA7,NOX4,PDE3B,PTGS2,RCAN1,SAMD4A,SDC4,SELE,SLC7A1,SPOCD1,VCAM1	Ap1,CREB1,CSF2,FOS,IL13,IL2,IL4,NFKB1,NFKBIA,NFkB (complex),NR3C1,Nfat (family),PPARG,PTGS2,RELA,STAT1,STAT3,STAT6,TP53	
P1	 	GW3965	 	chemical reagent	Activated	2.277	 	0.096	1.889	7.74E-05	ABCG1,APOE,ARG2,CD86,CXCL8,CYP11A1,DGAT2,IL6,LDLR,MMP9,NFKBIA,NR1D1,NR5A2,PLIN2,PLTP,PTGS2,RARA,SOCS3,THRSP	Ap1,CEBPA,CEBPB,ESR2,GW3965,NFKB2,NFkB (complex),Nr1h,PGR,RELA,RXRA,STAT1,STAT3,TP53,progesterone	
P1	 	IL1R1	-0.429	transmembrane receptor	 	-0.558	bias	0.323	-1.822	7.74E-05	ABCC1,ABCC3,CCL3L3,CXCL12,CXCL2,CXCL8,EGR1,FOS,IL6,LBP,LEP,MMP2,MMP9,MYH11,ORM1,PTGS2,SAA1,SELE,TIMP1	Ap1,IL1A,IL1B,IL1R1,IL6,JUN,MYD88,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3	
P1	 	MAPK9	0.221	kinase	 	0.521	 	0.211	-0.669	8.00E-05	ACACA,ACLY,BIRC3,BMP4,CAV1,CCL2,CIDEC,CXCL8,EDN1,EGR1,FOS,GADD45B,GAPDH,GSTM1,HDC,HIF1A,HMGA1,IER2,IL6,ISG20,JUN,JUNB,KLF6,LMNA,METAP2,MIF,MMP9,MYC,NCL,PLA2G4A,PLAT,PLIN2,PPP1R15A,PTX3,RILPL1,THRA,TNFAIP3,ZFP36	Ap1,FOS,HIF1A,IL1B,JUN,MAPK8,MAPK9,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF	
P1	 	FOXO4	-0.348	transcription regulator	 	-1.741	bias	0.264	-2.741	8.01E-05	ACACA,BCL2L1,CCND2,CCNG2,CDKN2B,CTGF,CYP51A1,DHCR24,ELOVL6,GADD45A,GADD45B,HIF1A,HMGCS1,IER3,MMP9,SGK1	ARNT,Akt,FOXO1,FOXO3,FOXO4,HIF1A,JUN,MYC,NFkB (complex),PPARG,SIRT1,STAT3,TP53,VHL	
P1	 	NPC1	0.311	transporter	 	0.109	 	-0.243	0.897	8.01E-05	ABCG1,AKR1C4,ATF4,CAV1,CCL3L3,CD68,CTSB,CTSD,CTSK,CYP27A1,DDIT3,GUSB,LDLR,PTGS2,S100A8,SRD5A1	25-hydroxycholesterol,ABCA1,APP,Ap1,FOS,HIF1A,NFE2L2,NFKBIA,NFkB (complex),NPC1,Nr1h,PPARA,PPARD,PPARG,RELA,SREBF1,SREBF2,STAT1,STAT3,Srebp,cholesterol,fatty acid	
P1	 	FOSL1	0.072	transcription regulator	 	1.995	 	0.036	1.853	8.14E-05	ADM,AXL,CCL2,CCL3L3,CXCL8,EGR1,EGR2,ELN,FOS,FOSB,IL6,JUN,JUNB,LHCGR,MMP2,MMP9,MT2A,PLAUR,SERPINE2,SFTPD,SPARC,THBD	Ap1,ESR1,ESR2,FOS,FOSL1,JUN,NFATC2,NFkB (complex),Nfat (family),PRDM1,SP1,STAT1	
P1	 	ARRB2	0.020	other	 	1.425	 	0.000	1.425	8.40E-05	ADRA2A,ADRB2,CXCL2,EGR1,GRK5,HIF1A,IL6,JUNB,MMP2,MYC,NFKBIZ,PTGS2	ARRB2,CEBPB,ERK,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,cyclic AMP	
P1	 	SB 216763	 	chemical toxicant	 	-1.500	bias	0.324	-2.652	8.57E-05	ACACA,CCL2,CCL8,CTGF,CXCL8,CYR61,FOSB,FSCN1,IL6,MYC,NR4A2,NR4A3,PTGS2,RGS1,TNFSF10	CEBPA,CEBPB,ERK1/2,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SB 216763,SMAD3,STAT1,STAT3,TNF,TP53,palmitic acid	
P1	 	2,3,4,7,8-pentachlorodibenzofuran	 	chemical toxicant	 	-0.529	 	0.096	-0.935	8.82E-05	CA3,CAT,CES1,COL1A1,COMT,CYB5A,CYP1B1,CYP2C8,EPB41L3,ESR1,GADD45A,HSPA1A/HSPA1B,HSPA2,IDH1,ITGA7,MYH11,NQO1,PTGFR	2,3,4,7,8-pentachlorodibenzofuran,CEBPB,ESR2,NFKB2,NFkB (complex),PGR,progesterone	
P1	 	MAPKAPK2	0.579	kinase	 	0.536	 	0.246	-0.479	8.82E-05	CCL2,CCL3L3,CEBPD,CXCL8,DDIT3,HDC,HSPA5,IL6,IRF3,LMO4,MARCO,MMP2,MMP9,NFKBIA,PLAT,RILPL1,TSC22D1,VCAM1	ATF2,CTNNB1,EGFR,ERK1/2,IL6,JUN,MAPKAPK2,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	metformin	 	chemical drug	 	-1.535	 	-0.170	-0.582	8.85E-05	ACACA,ADIPOQ,ADIPOR2,APOB,ATF3,ATF4,BAMBI,BIRC7,BMP2,CAV1,CCL2,CCND2,CXCL8,CYP11A1,DDIT3,DDIT4,DVL3,ERBB2,ERN1,FOS,FTH1,GRB14,HMOX1,HSPA5,IL6,LEP,MMP9,MYC,NFKBIA,PEA15,PKM,PLIN2,PTGS2,RARRES2,SLIT2,UCP2	ADIPOQ,D-glucose,FOXO1,Growth hormone,HIF1A,Insulin,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,STAT3,metformin,rosiglitazone	
P1	 	CEACAM1	-0.469	transporter	 	-1.648	 	0.137	-2.157	8.91E-05	ALDH1A1,ANG,ANGPT1,CD86,COL18A1,CXCL8,CXCR4,HEY1,KDR,LEP,RAE1,TEK,VEGFC,VEGFD	Akt,Ap1,CEACAM1,CEBPA,CEBPB,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	SUMO3	0.346	other	 	-0.742	 	-0.059	-0.523	8.91E-05	AGT,CAV1,CCND2,CD59,CXCL16,GRB14,HLA-G,HMGA1,HSPA8,IL6,LAMP3,LY6E,RNASE4,TNFRSF21	 	
P1	 	Immunoglobulin	 	complex	 	-0.849	 	-0.009	-0.789	9.13E-05	ACKR2,ADM,ALAS2,AQP9,BCL2L1,CBS/CBSL,CCL2,CCL3,CCL8,CCND2,CCND3,CD69,CD86,CDK4,CDKN1C,CRISPLD2,CSF1R,CXCL2,CXCL8,CYP1B1,DUSP1,EGR1,EGR2,ETS2,FCER1G,FCGR3A/FCGR3B,FOS,FOSB,HMOX1,IDO1,IL10RA,IL6,JCHAIN,KLF4,MMP2,MMP9,MYC,NCF2,NFKBIA,NLRP3,PTGS2,RRBP1,S100A8,S100A9,SLC11A1,SMOX,SPI1,STAB1,TFRC,TIMP1,TYMP,VCAM1,VCAN	IFNG,IL10,IL4,IL6,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,STAT6,TNF	
P1	 	26s Proteasome	 	complex	Inhibited	-2.279	bias	-0.258	-0.936	9.27E-05	ATF5,ATP6V1D,BHLHE22,BIRC3,BMP2,CCL2,CLCN7,CTSA,CTSB,CTSD,CXCL8,DDIT3,ESR1,IL6,JUNB,MCOLN1,NOTCH1,PKD1,PRNP,PSMB5,PTGS2,PTPA,S1PR1,SOCS3,SQSTM1,SRC,TNFSF10,UBE2I,UVRAG,VPS18	26s Proteasome,Ap1,CEBPA,CEBPB,CHUK,ERK1/2,HIF1A,IKBKB,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	CLOCK	-0.687	transcription regulator	 	 	 	 	 	9.82E-05	ACSL4,ADPGK,AK4,ANGPTL4,C1QBP,CD86,CLOCK,CYP51A1,DBP,DDIT3,ELOVL6,FAAP20,GADD45A,GADD45B,HES6,HSD17B8,ID1,JUNB,LIG3,LPIN1,MAP2K3,MGP,MID1IP1,MKNK2,PA2G4,POMGNT1,POR,RAD23A,RANGAP1,SLC20A1,ST6GALNAC4,TBRG4,TEF,THBD,TMED3,TMEM222,TNFRSF21	 	
P1	 	SIN3A	0.117	transcription regulator	 	1.342	bias	-0.401	2.239	1.02E-04	CCND2,CCNG2,COL1A2,CTSK,DDIT3,ESR1,GADD45B,HOXA9,ING1,KLF6,LHCGR,MMP9,MYC,NCL,PTGS2,S100A9,SIN3B,TGFBR2,TP53BP1	AR,CEBPA,CTNNB1,HDAC1,HDAC2,Hdac,Histone h4,MYC,NFkB (complex),RELA,SIN3A,SP1,SP3,STAT3,TP53,TP73,histone deacetylase	
P1	 	HNRNPA2B1	-0.438	other	 	 	 	 	 	1.03E-04	ADGRG2,CA12,CD24,CIDEC,CRIP1,DCLK1,FHL1,FSCN1,GDF15,H19,HIPK2,HNMT,HYAL1,IL6,INHBB,LEPR,LPAR1,MAST4,MMD,MOCOS,MSRB3,MYC,NPR3,NTRK3,PEG10,PKM,ROR1,S1PR3,SEMA3B,SRPX,STOM,SVEP1,TFPI2,TLE1,UBASH3B,VCAN	 	
P1	 	JUNB	-1.740	transcription regulator	 	-0.356	bias	0.313	-1.370	1.05E-04	ACAT2,ACLY,ATF3,CAV1,CCL3L3,CD68,CDC20,COL1A1,COL1A2,COL7A1,COMT,CXCL2,CYP1B1,DUSP1,FTH1,HMOX1,IL6,JUNB,LIPE,LPAR1,MMP2,MMP9,MVD,NCF2,PLAUR,PLIN1,POMC,SFTPD,SGK1,SLC7A1,SWAP70,TIMP1	Ap1,CTNNB1,ESR1,FOS,HDAC1,JUN,JUNB,NFATC2,NFKB1,NFKBIA,NFkB (complex),NOTCH1,Nfat (family),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,Vegf	
P1	 	GH1	0.345	growth factor	 	-1.603	 	0.130	-2.346	1.06E-04	ABCC1,ACACA,AGT,AKR1B1,ANGPTL4,APOE,ATF3,ATF4,BMP2,BMP4,CA3,CAT,CCND3,CEBPD,COL18A1,COL3A1,COMT,CXCR4,CYP2C8,DDIT3,DDT,EGR1,FOS,FTH1,GADD45A,GCDH,ID1,ID3,IGFBP3,IL6,ITGA1,JUN,JUNB,LDLR,LIPE,MYC,NR2F6,RAD23A,RPL6,SHMT2,SOCS2,SOCS3,SPP1,STC1,TF,TFF3,TSC22D1,ZFP36	AR,CEBPA,CEBPB,EGR1,ERK1/2,ESR1,ESR2,FOS,GH1,Growth hormone,HIF1A,IGF1,Ins1,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,PRL,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	testosterone	 	chemical - endogenous mammalian	Activated	2.704	 	0.240	0.857	1.11E-04	ABCC9,ADIPOQ,ADRA2A,ALDOA,ANXA3,ARF5,ARG2,ATP2B1,ATP6V1F,BMP4,CA3,CAST,CAT,CAV1,CDH2,CIZ1,CLCN3,CYB5A,CYP11A1,CYP26B1,CYP51A1,DHCR24,EGR1,ERBB2,ESR1,FOS,FOSB,FST,GADD45A,GFM1,GPC1,GUSB,HDC,HIF1A,HNRNPK,HSPA1A/HSPA1B,ID1,ID3,IL6,INHBB,IRS2,JUN,LEP,LHCGR,MAOA,NDRG1,NFKBIA,NGF,ODC1,PDE3B,PMP22,POMC,PRKCE,PTGS2,RALA,RARA,SLC25A10,SLC39A8,SLC6A9,SLC9A1,SRD5A1,SYT11,TF,TGFBR2,THBS1,TUBB2A,TXNRD1,VCAM1,VCAN	AR,CEBPB,ESR1,ESR2,FOXO1,Growth hormone,HIF1A,IGF1,Insulin,JUN,NCOR1,NFKB2,NFkB (complex),NR3C1,PGR,PPARA,PPARG,RELA,SMAD3,SP1,STAT3,TP53,beta-estradiol,progesterone,testosterone	
P1	 	RNA polymerase II	 	complex	 	 	 	 	 	1.12E-04	ADIPOQ,ALPL,ASNS,ATP13A2,CA12,CBX5,CCND2,CD14,CD4,CHEK2,COL1A2,CXCL2,CXCL8,CXCR4,CYP1B1,DDIT3,DDX11,DUSP1,ENO1,ERBB2,ESR1,FOS,FOXC1,GADD45A,GADD45B,GAPDH,GDF15,GOT1,HCST,HOXA9,HSD11B2,HSPA1A/HSPA1B,ID1,IGFBP3,IL6,JUNB,KPNA2,LDLR,MAP2K2,MMP2,MMP9,MYC,MYCN,NFKBIA,NR5A2,OSGIN1,PBX3,POMC,PTGS2,RBBP8,RPS21,SOCS3,SORBS1,SPI1,SPP1,TXN	Ap1,CDK9,EP300,ESR1,Histone h3,MYC,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TBP,TP53,TP73	
P1	 	MAX	0.349	transcription regulator	 	0.123	 	-0.113	0.526	1.15E-04	AEBP2,CBX5,CCND2,CCNG2,CDK4,CDKN2B,DDIT3,DKC1,DLEU1,EBF1,EDN1,FTH1,GADD45A,GADD45B,HMGA1,ID1,KLF6,LAMP2,LRRN3,MYC,NCL,ODC1,RBBP8,SLC2A3,TSC2	HMGA1,MAX,MYCN	
P1	 	Ni2+	 	chemical reagent	 	-1.096	bias	0.501	 	1.18E-04	ANGPTL4,ASNS,BIRC3,CCL2,CXCL2,CXCL8,HIF1A,IL6,NDRG1,PTGES2,VCAM1	APP,ATF2,Ap1,CXCR4,ESR2,HIF1A,MYC,NFKB1,NFKBIA,NFkB (complex),Ni2+,PPARA,PPARG,SP1,SREBF1,STAT1,STAT3,TP53,TP73,arachidonic acid	
P1	 	PRKCE	0.572	kinase	 	0.021	bias	0.437	-1.938	1.22E-04	BCL2L1,CAV1,CCND3,CD55,CXCL8,EGR1,FOS,HSPA5,IL6,IRF3,JUN,JUNB,LDLR,MMP9,MYC,ODC1,PDCD4,POMC,PRKCE,PTGS2,VCAM1	CREB1,ERK,ERK1/2,FOS,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,PRKCE,Pkc(s),RELA,Ras,SMAD3,SP1,STAT1,STAT3	
P1	 	PRNP	0.910	other	 	0.756	 	0.017	0.684	1.22E-04	APOE,ATF4,CTSD,DAB2,DLG4,EGR1,ETS2,FST,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPA9,LAMP2,MMP2,MYC,NOTCH1,PLAUR,PRND,PRNP,SOX9,TLE1	APP,CEBPB,CTNNB1,ERK1/2,HIF1A,IGF1,ITGB1,JUN,MYC,NFKBIA,NFkB (complex),PRNP,RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,TP53,TP73	
P1	 	PTPN11	-0.287	phosphatase	 	-0.801	 	0.077	-1.084	1.22E-04	ABCA3,ACSL4,BCL2L1,BSG,CD14,CD68,CSF1R,CSF3R,CXCL8,EGR1,ELANE,FOS,IL6,JUN,KDR,KIT,MCL1,PERP,PLAUR,SOCS3,ZMAT3	15-deoxy-delta-12,14 -PGJ 2,Ap1,HDAC1,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1,STAT3,TP53	
P1	 	ACSL5	0.285	enzyme	 	0.426	 	0.029	0.338	1.25E-04	ANOS1,GALNT13,GFPT2,KCNJ8,MCAM,MDK,MYRIP,PEG10,PHLDA2	 	
P1	 	triclosan	 	chemical drug	 	1.414	bias	0.368	0.374	1.25E-04	COL1A1,FOS,HMOX1,IL6,JUN,MBD3,NCF2,NQO1,TIMP1	Ap1,CEBPB,ESR1,ESR2,FOS,JUN,MAPK8,NFKB2,NFkB (complex),PGR,RELA,SP1,STAT3,TP53,beta-estradiol,progesterone,superoxide,triclosan	
P1	 	isoproterenol	 	chemical drug	 	0.534	bias	0.324	-1.272	1.27E-04	ABL1,ACSL3,ACSL4,ADIPOQ,ADRB2,ADRBK1,AGT,ALDH3B1,APLNR,ATF3,CAV1,CYP1B1,DHRS3,EDN1,FGF2,FOS,GRK5,HMOX1,IL6,JUN,JUNB,LEP,MMP2,MMP9,NGF,ODC1,PLAT,PLIN2,PPP1R1A,PRNP,PTGS2,TIMP1,TUBB,TYRO3,UCP2	CEBPB,CREB1,ERK,FOXO3,IL6,JUN,LEP,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,forskolin,isoproterenol	
P1	 	TFEB	0.309	transcription regulator	Activated	3.276	bias	0.473	1.531	1.28E-04	ARSA,CLCN7,CTSA,CTSB,CTSD,CTSK,GBA,HEXA,IL6,MCOLN1,NAGLU,NEU1,SGSH,TPP1	 	
P1	 	HNF1B	0.119	transcription regulator	 	-0.283	 	0.033	-0.454	1.28E-04	ACADVL,ACTN1,AKR1C4,COL5A1,COL5A2,DEFB1,DUSP1,F11R,FZD2,ID1,ID3,ID4,IGFBP3,ITGA3,LUM,MMP2,MPZL2,NID2,NR5A2,PKD1,PLAUR,PMP22,PTGIS,RNASE4,S100P,SEMA3C,SERPINH1,SLC22A12,SPARC,SULF1,UPP1	 	
P1	 	EIF2AK4	0.051	kinase	 	1.689	bias	0.394	0.342	1.29E-04	ASNS,ATF3,ATF4,CAT,CHAC1,DDIT3,EGR1,IL6,MBP,PCK2,PPP1R15A,PSAT1	 	
P1	 	TAB1	0.245	enzyme	 	1.890	bias	-0.287	2.874	1.29E-04	BIRC3,CFB,CH25H,CXCL8,GBP1,IL6,JUN,PTGS2,SAA1,SELE,TNFSF10,XAF1	Ap1,FOS,JUN,MAP3K7,MAPK8,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RCAN1,RELA,STAT3,TAB1	
P1	 	suramin	 	chemical drug	 	1.607	 	-0.019	1.670	1.29E-04	CCL2,CD86,CDH2,CXCL8,FGF2,FST,HMOX1,IL6,LOX,ODC1,PTGS2,SHC1	CEBPA,CEBPB,FOS,IL1B,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,STAT5a/b,TP53,suramin	
P1	 	L-cysteine	 	chemical - endogenous mammalian	 	-1.432	 	0.167	-1.802	1.30E-04	CDO1,CTNS,CXCL8,FOS,MYC,PCK2	Akt,Ap1,CREB1,CTNNB1,FOS,FOXO1,FOXO3,HIF1A,HMGA1,IRS1,JUN,L-cysteine,MAPK8,NFKB1,NFkB (complex),PI3K (complex),PTEN,RELA,SP1,STAT3,TP53	
P1	 	motexafin gadolinium	 	chemical drug	Inhibited	-2.449	bias	0.501	 	1.30E-04	MT1E,MT1F,MT1G,MT1L,MT1X,MT2A	 	
P1	 	Am 580	 	chemical toxicant	 	-0.208	bias	0.439	-1.757	1.32E-04	ADM,CD1C,CYP26B1,DUSP1,FOLR2,MYCN,PDCD4,PLAT,RARA,SOX9,TGM2,THBD,TIMP1	Am 580,CEBPB,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RXRA,STAT1,STAT3,THRB,cyclic AMP	
P1	 	CR1L	0.051	other	Inhibited	-2.279	bias	-0.439	-0.713	1.32E-04	COL15A1,COL18A1,COL1A1,COL1A2,COL3A1,COL5A1,COL6A1,COL6A3,COL8A1,CTGF,LUM,MGP,PTGER4	Akt,Ap1,CR1L,ERK,HIF1A,IL4,JUN,Jnk,NFkB (complex),RELA,SMAD3,STAT1,STAT3,STAT6,TP53	
P1	 	F7	0.485	peptidase	Inhibited	-3.076	bias	0.439	-4.614	1.32E-04	CTGF,CXCL2,CXCL8,CYR61,EGR1,FOS,GADD45A,HBEGF,IER2,IL6,MYC,PLAUR,ZFP36	Ap1,ERK,ERK1/2,F2RL1,F7,FOS,JUN,MAPK8,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3	
P1	 	Fgf	 	group	 	-0.497	bias	0.421	-1.864	1.32E-04	CCND3,FOS,GNL3,IL6,JUN,JUNB,KDR,MMP2,MMP9,ODC1,PTGS2,SPRY2,VCAM1	Akt,Ap1,ERK,FOS,Fgf,HIF1A,JUN,NFKB1,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,SRC,STAT3,TP53	
P1	 	parthenolide	 	chemical drug	 	1.156	 	-0.215	1.891	1.32E-04	BCL2L1,CCL2,CLDN5,CXCL2,CXCL8,DDIT3,HMOX1,IL6,MMP9,PDK4,PTGS2,TNFRSF10B,VCAM1	FOXO1,HIF1A,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT3,TP53,palmitic acid,parthenolide,reactive oxygen species	
P1	 	CEBPE	0.042	transcription regulator	 	0.030	 	0.238	-0.849	1.33E-04	B9D1,BCL2L1,CCND2,CD14,CDK4,CLEC10A,CSF1R,CSF3R,ELANE,IL6,ITGAM,LYZ,MBP,MMP2,MMP9,MYC,PTGS2	CEBPE,HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P1	 	PTK2	0.057	kinase	 	-0.103	bias	0.263	-1.099	1.33E-04	ACTA1,BIRC3,COL1A1,COL1A2,CSPG4,CYR61,FOS,IL6,KRT8,LDLR,LPP,MMP2,MMP9,PCOLCE2,THBS1,TIMP1,VCAM1	CEBPB,CTNNB1,ERK1/2,Focal adhesion kinase,HIF1A,ITGB1,JUN,MAP2K1,NFKB1,NFKBIA,NFkB (complex),PPARG,PTK2,RELA,RHOA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	quercetin	 	chemical drug	 	0.985	 	0.029	0.827	1.33E-04	ARRDC4,BCL2L1,CAV1,CCL2,COMT,CXCL8,EDN1,EGR1,ESR1,FBL,FOS,HIF1A,HMOX1,HSPA5,IL6,JUN,LDLR,LEP,LEPR,MCL1,MMP9,MYC,NFE2L1,ODC1,PIN1,PLAUR,POR,PRDX5,PTGS2,SELE,SMAD7,SOX9,TNFRSF10B,VCAM1	Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,quercetin,reactive oxygen species	
P1	 	KITLG	-0.202	growth factor	 	-0.717	bias	0.406	-2.892	1.36E-04	ATP6V1B2,AXL,BCL2L1,BTG1,BZW2,CCL2,CCL3L3,CCND3,CD14,CD68,CDKN2B,CIAPIN1,CPSF3,CSF3R,CTGF,CXCL8,CXCR4,DHCR24,EFNB2,EGR1,ELANE,FOS,FTH1,HMOX1,IGFBP3,IL6,KDR,KIT,KPNA2,LDLR,LY6E,MARCO,MID1IP1,MME,MMP2,MS4A2,NFKBIA,PDCD4,PGLS,PKM,PRKCE,PSMB5,PTGS2,RPLP0,SHC1,ST3GAL4,STIM1,TAF1C,TPSAB1/TPSB2,TXNL1,UCP2	Ap1,IL6,IRF8,JUN,KITLG,NFKBIA,NFkB (complex),PI3K (complex),PTPN11,RELA,Ras,SP1,SPI1,STAT1,STAT3	
P1	 	S100A8	-2.699	other	 	-1.186	 	0.110	-1.871	1.37E-04	ABCG1,ADAMTS1,AKAP12,ALDH1A1,ALPL,ARG2,ATF3,BCL2L1,BMF,C1QB,CCL2,CHDH,CXCL14,CXCL2,CXCL8,DDIT4,ELN,ENPP2,EPB41L4B,ETV5,GJB2,H19,HEY2,HMOX1,IDO1,IL6,ITGAM,KCNMA1,LOC102724788/PRODH,MGMT,MYH1,NFKBIA,NR4A3,NTRK3,PHLDA1,S100A8,SEMA3B,SGK1,TNFAIP8,VCAM1,VCAN	IL1B,IL6,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,S100A8,SP1,STAT1,STAT3,TP53	
P1	 	CTGF	-0.869	growth factor	 	-0.190	bias	0.272	-1.561	1.38E-04	ABCF1,ADAMTS1,BCL2L1,COL1A1,COL8A1,CTGF,EGR1,EMILIN1,ENO1,ESR1,FZD2,HIF1A,IL6,ITGA1,JUN,LHCGR,LIMS1,LOX,MMP2,MMP9,MYC,PTGFR,RAMP2,SDC4,SDPR,SFRP4,SPARC,TIMP1	Akt,Ap1,CTGF,ERK1/2,HIF1A,IL6,JUN,Jnk,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,TP53	
P1	 	ACOX1	0.051	enzyme	 	-0.780	 	-0.096	-0.213	1.40E-04	ACADM,ACADVL,ADAMTS1,AKR1C4,CAT,CD36,CRAT,CSTB,CXCL12,CYP2C8,DDIT3,ELOVL3,ETS2,GADD45A,GOT1,GSDMC,HSPA5,KLF6,KRT8,LHPP,LONP1,MYH1,NUPR1,PALMD,PDK4,PHLDA1,PLIN2,QPCT,RGN,RPS24,SGK1,SLC20A1,SLCO2B1,SQSTM1,TRIB3,UCP2	ACOX1,Ap1,JUN,NFkB (complex),PPARA,PPARD,PPARG,RXRA,SREBF1,fatty acid	
P1	 	bee venom	 	chemical - endogenous non-mammalian	 	-1.269	 	0.173	-1.997	1.40E-04	CCNL1,CXCL8,CYTIP,DDIT3,ETS2,FOSB,GADD45A,IFRD1,JUN,JUNB,KLF2,KLF4,LPIN2,MAP3K8,NFKBIA,NLRP3,NR4A2,NUPR1,NUSAP1,PPP1R15A,PTGS2,RCAN1,RGS1,SOCS3,THBD,TNFAIP3,TSC22D1	Ap1,FOS,HIF1A,JUN,MAPK8,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT3,TP53,bee venom	
P1	 	calphostin C	 	chemical - kinase inhibitor	 	0.186	bias	-0.448	1.992	1.45E-04	AGT,BCL2L1,CCL2,CD36,CXCL8,DUSP1,ETS1,FOS,GFPT1,HSPA5,IL6,KIT,LDLR,MAP3K12,MMP9,MYC,NGF,NQO1,PTGS2,S100A8	Ap1,CREB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PRKCE,Pkc(s),RELA,SMAD3,SP1,SRC,STAT1,STAT3,calphostin C	
P1	 	nicotine	 	chemical drug	 	1.150	bias	0.278	-0.330	1.55E-04	ALDOA,BMP2,CCL2,CCL3,CCND2,CD86,CLPTM1,CTGF,CTSK,CXCL8,DLG4,EDN1,EGR1,ENO1,FGF2,FOS,GJA4,HIF1A,HMOX1,HSPA8,ID1,IL6,ITGAM,JUNB,KCNK12,KDR,LDLR,LEP,LITAF,MMP2,MMP9,MYCN,NSF,PLAT,PLAUR,POMC,PTGS2,PTPRA,SELE,SLC20A1,SPP1,TFPI2,ZFP36	D-glucose,ERK1/2,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SMAD3,SP1,SRC,STAT3,nicotine	
P1	 	topotecan	 	chemical drug	 	-1.135	 	-0.184	0.019	1.55E-04	AKAP12,ASTN2,ATF3,BTG1,CYB5A,DUSP5,EGR1,EGR3,ENO1,FAT1,FOSB,GDF15,GPC6,HIF1A,HNRNPK,HSPA1A/HSPA1B,HSPA8,JUNB,KCNMA1,KIAA0040,MAP2K5,MCL1,MYC,MYCN,NBEA,NINJ1,NLGN1,NNAT,PCDH9,PHKG1,PRNP,PTGS2,PTPRK,PTPRT,RELN,SAC3D1,SESN2,SLC7A5,SRSF3,STK39,TRAP1,XPO6,ZER1	AMPK,Ap1,FOXO1,JUN,MYC,NFKBIA,NFkB (complex),PI3K (complex),PPARGC1A,SP1,STAT1,STAT3,TP53,TP73,topotecan	
P1	 	ATF3	-1.957	transcription regulator	 	0.633	 	-0.063	0.870	1.55E-04	ADIPOQ,ASNS,ATF3,BHLHE41,BIRC3,CDK4,CHAC1,DDIT3,FBP1,ID1,IL6,ITGA1,JUN,LDLR,MMP2,MT2A,NUPR1,PPP1R15A,SELE,SLC11A1,TNFRSF10B	ATF3,Ap1,IFNG,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,TP73	
P1	 	E. coli B5 lipopolysaccharide	 	chemical - endogenous non-mammalian	Inhibited	-4.471	 	0.243	-6.245	1.56E-04	ADAMTS1,ADH1C,ADRB2,AKR1C4,ALDH2,BIRC3,CAT,CCL18,CCL2,CCL3L3,CCR1,CD69,CD86,CES1,CHFR,CIDEA,CSF3R,CXCL2,CXCL8,CXCR4,CYP11A1,DNAJB2,DUSP1,ETS2,FMO1,FOS,GCLM,HMOX1,IDO1,IL18RAP,IL6,INHBB,ISG20,JUNB,LDLR,MAP3K8,MED20,NCF2,NEDD4L,NFKBIA,PHLDA1,PTGS2,RHOB,SELE,SEPHS2,SOCS2,SOCS3,SPINT2,SPP1,TGFBR2,TGFBR3,TGM2,THBS1,TNFAIP3,TPO,UBE2I	E. coli B5 lipopolysaccharide,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF	
P1	 	AFP	0.091	transporter	 	-1.732	 	0.201	-2.218	1.59E-04	EGR1,EGR2,FOS,MMP9,TNFRSF10B,TNFRSF12A,TSC22D1	17-alpha-ethinylestradiol,AFP,Ap1,CEBPA,ESR1,Histone h3,N-cor,NFkB (complex),RELA,RNA polymerase II,SP1	
P1	 	CHRM3	0.166	g-protein coupled receptor	 	-0.640	bias	0.501	 	1.59E-04	CYR61,EGR1,FOS,HMOX1,ITGA3,LEP,MMP9	Ap1,CHRM1,CHRM3,CREB1,Ca2+,EGR1,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RAC1,RELA,SP1,SRF,STAT3,TP53	
P1	 	PCDH11Y	0.102	other	 	-0.784	bias	0.501	 	1.64E-04	AES,AXIN1,AXIN2,BMP4,CCND3,JUN,MYC,PTGS2,RET,SFRP2	CTNNB1,HDAC1,JUN,NFkB (complex),PCDH11Y,STAT3,TCF	
P1	 	acetaldehyde	 	chemical - endogenous mammalian	 	0.902	bias	0.358	-0.212	1.64E-04	COL1A1,COL1A2,FOS,IL6,JUN,KLF9,MMP2,MYC,SMOX,TIMP1	Ap1,ERK1/2,ESR1,FOS,JUN,Jnk,MAPK8,NFATC2,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,acetaldehyde	
P1	 	mir-146	0.092	microrna	 	0.867	bias	-0.393	2.292	1.66E-04	CAT,CCL2,CCL3,CXCL8,DUSP1,FAF1,IL6,IRAK1,KIT,MBP,MMP2,MYC,NLGN1,PTGS2,RUNX1	CCL5,CREB1,HIF1A,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,mir-146	
P1	 	docosahexaenoic acid	 	chemical drug	 	0.130	 	-0.204	1.337	1.66E-04	ACACA,ADIPOQ,APOE,ATF4,BCL2L1,CD86,COL1A1,CTGF,CXCL8,CXCR4,DDIT3,ELOVL6,ERN1,FOS,HMOX1,IL6,LDLR,LEP,LOX,MMP2,MMP9,MYC,NOX4,PLAT,PLTP,PTGS2,SELE,SERPINH1,SMAD6,SMAD7,SMPD1,SOCS3,SORL1,TGFBR2,THBS1,TIMP1,UCP2,VCAM1	Akt,ERK1/2,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TNF,TP53,docosahexaenoic acid	
P1	 	mir-223	0.041	microrna	 	-1.209	 	0.124	-1.897	1.72E-04	ALCAM,C5AR1,C7,CA4,CARM1,CD36,CRHBP,CTSG,CYB5A,EGR2,EGR3,ELANE,EMP1,FCER1A,FNIP2,GFPT1,GSTM5,HMGCS1,IL6,LY96,MMP25,MSMO1,MT1E,MYO1D,MYOF,NLRP3,NQO1,PADI4,RAB38,S100A9,SGPL1,TOB1	 	
P1	 	MYOC	-1.503	other	 	0.713	bias	0.275	-0.002	1.72E-04	ADAMTS1,DAB2,DDIT3,DDIT4,DPP7,EGR2,FSCN1,HSPA5,INHBE,KCNJ2,LAMA2,MBP,MFAP2,NOL3,PHLDA2,PTGER4,RGS17,SESN2,SFRP1,SLC2A3,SPP1,STC1,STC2,UPP1,VAPA	EGR1,FOS,FOXO1,FOXO3,JUN,MAPK1,MXI1,MYOC,NFkB (complex),SP1,STAT1,STAT3,TP53	
P1	 	5-azacytidine	 	chemical drug	 	-0.196	bias	0.419	-2.567	1.72E-04	BCL2L1,CANX,CAV1,CDKN2B,COL1A1,CXCL12,DUSP1,ESR1,ETV5,FYN,GADD45A,GDF15,HBEGF,HSPA5,HSPA8,IRS2,KLF6,LOX,MCL1,MGMT,PCDHA1,PTGS2,SHC1,SLC3A2,SLC7A5,SLC9A1,SOCS3,SOX9,TFPI2,TGFBR2,TGM2,THBS1,TNFRSF10B,TUBB,UPP1	5-azacytidine,AR,Ap1,EGR1,ESR1,HDAC1,Histone h3,MECP2,NCOR1,NR3C1,RELA,RNA polymerase II,SMAD3,SP1,SP3,SPI1,STAT3,TP53	
P1	 	SUMO2	0.235	enzyme	 	-0.742	 	-0.076	-0.460	1.80E-04	AGT,CAV1,CCND2,CD59,CXCL16,GRB14,HLA-G,HMGA1,HSPA8,IL6,LAMP3,LY6E,RNASE4,TNFRSF21	APP,Ap1,EGR1,ESR1,HIF1A,NFKBIA,NFkB (complex),SMAD3,SP1,STAT1,STAT3,SUMO2,TP53	
P1	 	conjugated linoleic acid	 	chemical drug	 	1.129	 	0.036	1.022	1.80E-04	ANGPTL4,CBS/CBSL,CTSK,CXCL8,CXCR4,DUSP1,FOS,GDF15,IL10RA,LEP,MMP9,PTGS2,SOCS3,VEGFD	CEBPA,CEBPB,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TNFSF11,TP53,conjugated linoleic acid	
P1	 	HLX	-0.170	transcription regulator	 	0.714	 	-0.219	1.497	1.90E-04	BMP2,CDKN1C,CXCL8,CYP1B1,EGR1,ELK1,GDF15,JUN,MYC,PLXNA1,SEMA3G,THY1,UNC5B	CTNNB1,HDAC1,HDAC2,HLX,SIN3A,SP1,TP53	
P1	 	SELPLG	0.028	other	Inhibited	-3.051	bias	0.471	-4.749	1.90E-04	CCL2,CCL3,CXCL2,CXCL8,CXCR4,CYP1B1,FOS,HCAR3,IDO1,ITGAM,PLAUR,PRKCD,THBD	CEBPB,IFNG,IL17A,IL4,IL6,JUN,NFKBIA,NFkB (complex),RELA,SELPLG,SMAD3,SMAD4,SP1,STAT1,STAT3,STAT6,TGFB1	
P1	 	propylthiouracil	 	chemical drug	 	0.000	 	0.107	-0.215	1.98E-04	ABCA3,ABCC3,ADSSL1,AKR1C3,BTG2,CCND3,CD69,CS,CXCL2,ELOVL3,FMO3,G6PD,GBP4,GLUL,HCAR2,JUN,LOC102724788/PRODH,MYH11,NNMT,NRP1,NSMF,PCOLCE2,PHLDA1,QPCT,SLC2A5,THRA,THRSP,TPO	AR,PRL,SP1,STAT1,STAT3,TP53,propylthiouracil	
P1	 	romidepsin	 	biologic drug	 	-0.323	 	0.147	-0.705	2.00E-04	BCL2L1,CD86,CDKN2B,DDIT3,DUSP1,EGR1,ERBB2,FGF2,FOS,HIF1A,JUN,MMP9,MYC,PLAUR,PTGS2,SPRY2,TNFRSF10B,VHL	Ap1,ELK1,ERK1/2,FOS,HIF1A,JUN,MAPK3,NFKBIA,NFkB (complex),PI3K (complex),RAF1,RELA,SMAD3,SP1,STAT3,reactive oxygen species,romidepsin	
P1	 	Rock	 	group	 	-1.200	 	0.215	-1.938	2.01E-04	ACTA1,BMP2,CCL2,COL1A1,COL3A1,CTGF,CXCL8,ETS1,FOS,LPP,MYC,NOP16,SOX9,SPP1,TJP1,VCAM1	Akt,Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RHOA,Rock,SMAD3,STAT3,TP53	
P1	 	Esrra	 	transcription regulator	 	1.140	 	0.100	0.722	2.09E-04	ACADM,AGL,ALDOA,ALDOC,ATP5G1,CH25H,COX7A2L,COX8A,CRAT,CYC1,ENO1,FBP1,GALM,GYS1,IL6,NDUFS3,PCK2,PDK4,PFKL,PHKG1,PTGS2,SOX9,SPP1,THRA	Esrra,FOXO1,PPARA,PPARD,PPARG,PPARGC1A,RXRA	
P1	 	POU2F1	-0.167	transcription regulator	 	-0.687	 	0.185	-1.084	2.11E-04	AOX1,CD55,CDO1,CSF1R,CXCL8,CYP2C8,DDIT4,ELK1,ESR1,GADD45A,GCLM,GPX3,GSTM1,GSTM3,GSTM5,HOMER3,IDH1,IL6,IRF3,LY6E,MYH1,PTGDS,RN7SK,SAA1,SELE,SESN2,SPP1,TNFAIP3,TNFRSF14,VCAM1,ZFP42	EP300,JUN,NFkB (complex),NR3C1,POU2F1,RELA,STAT1	
P1	 	TP63	-0.128	transcription regulator	Activated	2.343	 	0.190	1.046	2.14E-04	ADAMTS1,ADM,ADRM1,AEN,ALDH1A3,ANOS1,ATG7,ATG9A,BCL2L1,CA4,CAST,CCND2,CCND3,CDH2,CDKN1C,CDKN2B,COL5A1,CSTA,CTSD,CXCL8,CYR61,DAP3,DDIT4,DUSP10,EMP1,FOS,FST,GADD45A,HAGH,HBEGF,HSPA8,ID1,IER3,IGFBP3,IGFBP6,IL6,ING1,ITGA3,ITGA7,JUNB,KCNG1,KLF6,LLGL1,LYN,MAP2K3,MPZL2,MYC,NOTCH1,PERP,PKP2,POLD2,PRNP,RBBP8,REXO4,RPA1,RUNX1,S100A8,SPATA18,STX1A,TAGLN,THAP8,THBS1,THY1,TNFAIP8,TNFRSF10B,TPM1,TPP1,TRIM6,TSC2,UVRAG	Akt,CEBPA,CEBPB,ERK,FOS,HIF1A,Hdac,JUN,MYC,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,TP63,TP73,YBX1	
P1	 	Ap1	 	complex	 	-1.944	bias	0.452	-3.854	2.18E-04	ATF3,CCL2,CCL3,CCL3L3,CXCL12,CXCL8,DDIT3,EDN1,ERCC1,ETS1,FOS,GSS,HMBS,HMOX1,IGFBP3,IL17D,IL6,JUN,LHCGR,MMP2,MMP9,MT2A,MYC,NDRG1,NGF,NQO1,PADI4,PLA2G2A,PTGS2,RSPO3,SELE,SFTPD,SPARC,SPP1,TIMP1,VCAM1	Ap1,CREB1,CSF2,CTNNB1,FOS,HDAC1,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,NR3C1,RELA,SMAD3,SP1,STAT1,STAT3,Vegf	
P1	 	FOXL2	0.087	transcription regulator	Inhibited	-2.199	bias	0.277	-3.362	2.18E-04	ATF3,CCL3,CCL3L1,CCL3L3,CH25H,CXCL2,CYP26B1,FOS,FST,IER3,NR4A3,NR5A2,PPP1R15A,PTGS2,RSPO3,SMAD6,SOX9,SPRY1,TNFAIP3	CREB1,FOS,FOXL2,FSH,JUN,Lh,NFkB (complex),SMAD3,STAT1,STAT5B	
P1	 	MMP9	0.592	peptidase	 	-0.249	 	0.047	-0.440	2.18E-04	BCL2L1,CCL3L3,CLDN5,COL18A1,CTSB,CXCL12,CXCL2,CXCR4,DDIT3,FOS,GADD45A,IL6,MMP2,MMP9,MYC,SDC4,SERPINE2,TIMP1,TJP1	APP,HIF1A,IL1B,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3	
P1	 	Y 27632	 	chemical drug	 	1.625	 	-0.210	2.471	2.18E-04	ACTA1,BMP2,BMP4,CCL2,CDK4,CLDN5,CTGF,FOS,IL6,MMP2,MMP9,MYC,MYH11,PTGS2,SOX9,TAGLN,THBS1,TJP1,VCAM1	APP,Akt,Creb,ERK1/2,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),P38 MAPK,RELA,Rock,SMAD3,SRF,STAT1,STAT3,TP53,Y 27632	
P1	 	phenylephrine	 	chemical drug	 	-1.305	bias	0.294	-2.552	2.18E-04	ACTA1,ANGPT1,ATF6,ATP2A2,BNIP3L,COL3A1,DUSP1,EDN1,EDNRA,EGR1,FOS,FST,ITPR2,JUN,MYC,PDK4,RCAN1,SLC9A1,THRA	ADRA1B,CREBBP,EDN1,EP300,ERK,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,phenylephrine	
P1	 	BID	0.144	other	 	0.923	bias	0.446	-0.403	2.20E-04	ADAM17,C5AR1,CTSB,CTSD,CTSH,CTSK,CXCL8,IL6,TIMP1	Akt,BID,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P1	 	LYL1	0.044	transcription regulator	 	0.816	 	0.116	0.533	2.20E-04	ADGRG1,BCL2L1,BTG2,CCND3,CDH5,EGR1,ID1,ID3,ID4	 	
P1	 	RARRES2	-1.543	transmembrane receptor	 	-1.718	 	0.056	-1.883	2.20E-04	ADIPOQ,CCND2,CD55,CXCL2,CYP11A1,IL6,LEP,LIPE,PLIN1	ESR1,ESR2,RARRES2,RELA,SP1,STAT3,beta-estradiol	
P1	 	D-fructose	 	chemical - endogenous mammalian	 	0.405	bias	0.474	-1.287	2.26E-04	ACACA,ADIPOQ,AGT,CD68,COL1A1,COL3A1,CXCL2,HP,IL6,ITGAM,MMP2,SLC2A5,SLC2A8,THBS1,TIMP1	CREB1,CTNNB1,D-fructose,FOXO1,FOXO3,HMGA1,IFNG,IRS1,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SIRT1,STAT1,STAT3,TNF	
P1	 	6,7-dinitroquinoxaline-2,3-dione	 	chemical reagent	Inhibited	-2.000	bias	0.501	 	2.35E-04	EGR1,FOS,FOSB,JUN,JUNB	5-hydroxytryptamine,6,7-dinitroquinoxaline-2,3-dione,Ap1,ESR1,FOXO3,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),STAT1	
P1	 	SERCA	 	group	Activated	2.191	bias	-0.501	 	2.35E-04	BTG2,EGR1,JUN,MYC,ZFP36	Akt,CREB1,Ca2+,ERK,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SERCA,SMAD3,SP1,STAT3,TP53	
P1	 	STX2	-0.066	transporter	 	-0.447	 	0.167	-0.821	2.35E-04	BMP2,BMP4,MMP2,MYC,SMAD7	CTNNB1,HDAC1,IL6,JUN,MMP9,NFKB1,NFkB (complex),NOTCH1,RELA,SP1,STAT1,STAT3,STX2,TCF	
P1	 	histidinol	 	chemical - endogenous mammalian	 	1.400	bias	0.501	 	2.35E-04	ASNS,ATF4,EGR1,SLC7A1,SLC7A5	 	
P1	 	vanillyl-N-nonylamide	 	chemical drug	 	 	 	 	 	2.35E-04	ATF3,CCNG2,DDIT3,GADD45A,HSPA5	CREB1,Ca2+,NFkB (complex),SP1,STAT3,TP53,vanillyl-N-nonylamide	
P1	 	TGFBR1	0.019	kinase	 	-1.876	bias	0.331	-3.264	2.43E-04	BMP4,CD86,CDK4,CLDN5,COL1A1,COL1A2,CTGF,EDN1,EGR2,GJA4,HEY1,HMOX1,ID4,OSR1,PDK4,RUNX1,SMAD7,TAGLN,TPSAB1/TPSB2,VEGFC,ZFP36	GATA4,JUN,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,RELA,RUNX2,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TGFB1,TGFBR1	
P1	 	ESRRA	0.350	ligand-dependent nuclear receptor	 	1.391	bias	0.461	-0.679	2.49E-04	ACADM,ACADVL,ALDOC,ATP2A2,CD36,CDH2,CSAD,CYB5A,CYP51A1,ENO1,FAM102A,GAPDH,GOT1,HADHA,HK1,HMGCS1,LIPE,MTCH2,NR1D1,PCK2,PDK4,PKM,PLIN1,PRKCD,THRA,UBALD1	ESRRA,FOXO1,PPARA,PPARD,PPARG,PPARGC1A,RXRA	
P1	 	CP-55940	 	chemical reagent	Inhibited	-2.776	bias	0.418	-3.936	2.50E-04	ALDOC,BCL2L1,BTG2,CCL2,CXCL8,ERBB2,GADD45A,GAPDH,GRK5,JUN,JUNB,MYC,NFKBIA,TNFAIP3	Akt,Ap1,CP-55940,CREB1,Ca2+,ERK,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,nitric oxide	
P1	 	CYR61	-2.755	other	 	-0.724	bias	0.349	-1.927	2.50E-04	BCL2L1,CCL2,COL1A1,COL1A2,CXCL8,CYR61,ESR1,HIF1A,ITGA3,MCL1,MYC,TIMP1,TNFSF10,VEGFC	CYR61,ERK1/2,FGF2,GSK3B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	nitrofen	 	chemical toxicant	 	-0.434	bias	-0.501	 	2.50E-04	AGTRAP,APLNR,CLCN7,EGR1,ENO1,EPAS1,HK1,HYOU1,KCNJ8,PLD3,RARA,RTN4,TGFBR2,TGFBR3	 	
P1	 	DUSP1	-2.120	phosphatase	 	1.999	 	-0.150	2.696	2.54E-04	CCL2,CCL3L3,CD86,CIDEA,CIDEC,CLEC10A,CXCL2,CXCL8,DUSP1,ELOVL3,IER3,IL6,ISG20,JUN,MYH1,PAQR7,PLAUR,PLIN2,PTGS2,S100A9,SELE,VCAM1,ZFP36	Ap1,DUSP1,IFNG,IL10,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,ZFP36	
P1	 	SBDS	-0.357	other	 	 	 	 	 	2.54E-04	AKR1C3,CHAC1,CRABP1,CRYM,CTGF,DDIT3,DPYD,EGR1,FOS,GABRE,GADD45B,GAP43,HSPA5,ID1,INHBE,KIF1A,MAOA,MT2A,PCDH7,PPP1R15A,PPP1R1A,PSMD7,SPP1,TRIB3	AR,CEBPA,CEBPB,DDIT3,EGR1,JUN,NFAT (complex),NFkB (complex),RELA,SBDS,SIRT1,SP1	
P1	 	di(2-ethylhexyl) phthalate	 	chemical toxicant	Inhibited	-2.012	 	0.173	-2.736	2.58E-04	ALDH3A1,BSG,CCL2,CCND2,CD36,CXCL8,EGR1,FOS,FOSB,IKBKG,JUN,LHCGR,MYC,POR,SLC27A1,SLCO2A1,SLCO2B1,ZFP36	Ap1,CAT,CREB1,D-glucose,HIF1A,JUN,Lh,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SREBF1,STAT1,STAT3,STAT5B,TP53,di(2-ethylhexyl) phthalate	
P1	 	rotenone	 	chemical toxicant	 	0.187	 	-0.029	0.308	2.58E-04	AGT,ATF4,BIRC3,BSG,CXCL2,DDIT3,FOS,HIF1A,HMOX1,IL6,ITGAM,KDR,MMP9,NR4A2,PTGS2,TIMP1,UCP2,VCAM1	Ap1,CEBPA,CEBPB,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,SP1,SREBF1,STAT1,STAT3,TP53,fatty acid,hydrogen peroxide,rotenone	
P1	 	SEMA7A	0.152	transmembrane receptor	 	1.265	bias	0.501	 	2.64E-04	COL1A1,COL1A2,COL3A1,CTGF,CTSB,EGR1,ELN,FGF2,SMAD6,TIMP1	CTNNB1,HIF1A,ITGB1,SEMA7A,STAT1,STAT3,STAT5a/b	
P1	 	ADRA1B	0.724	g-protein coupled receptor	 	0.000	 	0.116	-0.283	2.67E-04	ACTA1,ADRA1A,APBA3,CEBPD,COL3A1,DUSP1,EGR1,EGR2,FOS,IL6,JUN,LEP,LOX,NFIX,NR4A2,RALA	ADRA1B,ADRA1D,CEBPA,CEBPB,CREB1,CREBBP,Creb,EP300,GATA4,JUN,MEF2C,NFkB (complex),RELA,STAT1,STAT3,TP53,norepinephrine,phenylephrine,prazosin	
P1	 	STAT5B	-0.436	transcription regulator	 	-0.938	 	0.125	-1.620	2.68E-04	AHNAK,AKR1C3,ATP2A2,BCL2L1,BIRC3,CASP4,CCL3L3,CCND2,CCND3,CD276,CDO1,CIDEA,DGAT2,EBF1,ESR1,FOS,GADD45A,HEXA,IL6,LEP,LTBR,MAF,MCL1,ME1,MYC,MYH1,NOL3,NR4A2,PPP1R3C,RASD1,RPA1,SH3RF3,SOCS2,SOCS3,THRSP,TNFRSF14,TNFRSF4,WARS,ZFP36	AKT1,CEBPB,HIF1A,IGF1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT5B,TNF,TP53	
P1	 	TCF3	0.381	transcription regulator	 	-0.156	 	0.063	-0.438	2.75E-04	ADIPOQ,AP3D1,ARSA,ATF3,AXIN2,CCND2,CCND3,CD4,CDH5,CDKN2B,CDKN2C,COL1A1,CYP11A1,DOCK1,EBF1,EIF4EBP1,ELANE,EPB42,EPRS,ETS2,FAM86C1,GADD45A,GADD45B,GM2A,GPAM,HADHA,HSD17B14,JUN,KIT,KLF4,LHCGR,LMO4,LRBA,MSMO1,MYC,MYCN,NOTCH1,NR4A3,NUSAP1,RGS16,SCIN,SEMA3G,SLC12A2,SLC7A5,SOCS3,TCEAL9,TF,ZP3	Ap1,ESR1,Histone h3,ID3,MYOD1,RELA,RNA polymerase II,SP1,TCF3	
P1	 	MYCN	0.512	transcription regulator	Activated	3.460	 	0.104	2.746	2.77E-04	ABCC1,AEBP2,ALDH1A1,ALDOA,BCL2L1,CAV1,CCND2,CCNG2,CKAP4,COL18A1,COL1A1,COL5A2,COL8A1,CTDNEP1,CTGF,DKK3,EEF1G,EIF3C,GAPDH,HMGA1,ITGA3,LRRN3,MMP2,MSRB3,MYCN,NCL,NME1,ODC1,P3H1,PSMB6,PSMB7,RGS5,RPL6,RPL8,RPL9,RPLP0,RPLP1,RPS2,RPS24,SLC25A19,SLIT3,SORD,SOX17,SPARC,TAGLN,TGM2,TM6SF1,TMED9,TNFRSF10B,TPM1,TUBB,TUFM,UCHL1	ATF2,Ap1,CDK9,EP300,ERK,HMGA1,JUN,MYCN,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TP53,estrogen receptor	
P1	 	FBXW7	-0.315	transcription regulator	 	0.863	bias	-0.401	1.987	2.83E-04	CD36,CIDEC,COL1A1,DDX11,DGAT2,GPAM,HEY1,JUN,MYC,NOTCH1,NQO1	ATF2,Ap1,CEBPA,EGFR,FBXW7,FOS,HDAC1,JUN,MYC,NFkB (complex),NOTCH1,NOTCH4,PPARG,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	TAF4B	0.283	transcription regulator	 	-0.446	bias	0.501	 	2.83E-04	CCND2,CTGF,FST,IER3,INHBB,JCHAIN,JUN,NFKBIA,RET,SPP1,TNFAIP3	 	
P1	 	TRIB3	5.135	kinase	Inhibited	-2.720	 	-0.231	-1.964	2.83E-04	ASNS,DDIT3,DDIT4,GARS,GDF15,ID1,MTHFD2,PCK2,PSAT1,STC2,TRIB3	ATF4,CEBPA,CEBPB,DDIT3,HIF1A,JUN,NFAT (complex),NFE2L2,NFkB (complex),PPARG,RNA polymerase II,STAT3,TRIB3	
P1	 	PTX3	1.630	other	 	0.871	bias	-0.334	1.999	2.83E-04	CCL2,CCL3L3,CTGF,CXCL2,CXCL8,EGR2,EGR3,FOS,IL6,IRAK1,JUN,MMP9	ERK1/2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PTX3,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	CSF2RB	-0.084	transmembrane receptor	 	-0.692	bias	0.424	-1.798	2.84E-04	BCL2L1,CCND2,FOS,IL6,ITGAM,JUN,JUNB,MYC	CSF2RA,CSF2RB,ERK,ERK1/2,FOXO3,IL3,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,STAT5A,STAT5B,STAT5a/b,STAT6	
P1	 	PLIN1	-1.850	other	 	-0.246	 	-0.201	0.198	2.84E-04	ABHD5,ACACA,ACADM,ACADVL,CIDEC,HADHA,LEP,UCP2	NFkB (complex),PLIN1,PPARA,PPARD,PPARG,SREBF1,fatty acid	
P1	 	PNN	0.289	other	 	0.000	 	-0.143	0.405	2.84E-04	BCL2L1,BSG,CDK4,GDF15,JUN,MYC,TBRG4,TIMP1	 	
P1	 	leukotriene C4	 	chemical - endogenous mammalian	Inhibited	-2.231	bias	0.501	 	2.84E-04	CCL2,CXCL8,EGR1,EGR2,EGR3,FOS,PTGS2,VCAM1	Ap1,ESR2,FOS,HIF1A,IL4,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,STAT6,leukotriene C4,reactive oxygen species	
P1	 	methylmercury	 	chemical toxicant	 	-0.447	 	0.069	-0.758	2.92E-04	ACVR1C,ATF5,BCL2L1,COL1A1,COL3A1,DHCR24,EGR1,FBXO3,HMOX1,IGFBP3,IL6,LTBR,MAPKAPK2,NR2F6,PLS3,PTPRF,RHOB,RTN4,SPARC,STOM	CAT,ERK1/2,IL6,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53,methylmercury	
P1	 	Go 6976	 	chemical - kinase inhibitor	 	1.624	bias	-0.442	3.414	3.02E-04	ACTA1,BMP2,BMP6,CD55,CXCL2,CXCL8,ERBB2,ETS1,FOS,HMOX1,MMP2,MMP9,NFKBIA,PTGS2,STC1,TNFRSF4,VCAM1	Ap1,Go 6976,HIF1A,IKBKB,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCA,RELA,STAT3	
P1	 	platelet activating factor	 	chemical - endogenous mammalian	 	-0.143	bias	0.361	-1.576	3.02E-04	CCL2,CD69,CDH2,EGR1,EGR2,FGF2,FOS,IDO1,IL6,ITGAM,MMP2,MMP9,NFKBIA,PLAUR,PTGS2,THBS1,TIMP1	Ap1,CEBPA,CEBPB,ERK,IL6,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53,platelet activating factor	
P1	 	sulindac sulfide	 	chemical drug	 	0.288	 	-0.074	0.616	3.02E-04	ATF3,BCL2L1,CTGF,CYP1B1,EGR1,GADD45A,GARS,GDF15,IFRD1,MSMO1,MTHFD2,NQO1,PPP2R1A,PRSS23,PTGS2,RAP1GAP,RRM2B,SPTBN1,STC1,STC2,TNFRSF10B	Ap1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,Ras,SMAD3,SP1,STAT1,STAT3,TP53,sulindac sulfide	
P1	 	Ro31-8220	 	chemical - kinase inhibitor	 	1.185	bias	-0.408	2.729	3.05E-04	BCL2L1,CCL2,CD55,COL1A1,COL1A2,CXCL8,DUSP1,EGR1,HMOX1,IL6,MMP2,PDCD4,PTGS2,TNFSF10,VCAM1	Ap1,CREB1,FOS,HIF1A,JUN,Jnk,MIF,NFKB1,NFKBIA,NFkB (complex),PRKCE,Pkc(s),RELA,Ro31-8220,STAT1,STAT3,TP53	
P1	 	tanespimycin	 	chemical drug	 	1.307	 	-0.246	2.607	3.18E-04	AHSA1,AXL,BCL2L1,BIRC3,CAV1,CDK4,CDKN2B,CXCL8,DDIT3,DLG4,ERBB2,HSPA1A/HSPA1B,HSPA5,HSPA8,HSPA9,IARS,JUN,KIT,KRT8,LYN,MCL1,MIF,MYC,SERPINH1,SNRPB,SRC,SYN1,TNFAIP3,TYMP	ARNT,ATF2,EGFR,ERK1/2,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,SP1,STAT3,TP53,VHL,tanespimycin	
P1	 	H89	 	chemical - kinase inhibitor	 	0.391	bias	-0.340	2.208	3.20E-04	ADIPOQ,BCL2L1,CCL3,CD14,CD55,CXCL8,DUSP1,EGR1,EGR2,EGR3,FGF2,FOS,HMOX1,IL6,ITPR2,LHCGR,MMP2,MMP9,MYC,NFKBIA,NR4A2,PDE3B,POMC,PPP1R16B,PTGS2,RUNX1,S100A8,SHC1,SIGMAR1,TXN,UCP2,VCAM1	CEBPA,CEBPB,CREB1,FOS,H89,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT1,STAT3,TNF,TP53	
P1	 	BLVRA	0.061	enzyme	 	0.000	 	0.000	0.000	3.28E-04	HMOX1,JUN,TNFRSF10B,TNFSF10	 	
P1	 	CYP	 	group	Activated	2.000	bias	0.501	 	3.28E-04	CD86,GCLM,HMOX1,NQO1	AHR,ATF2,ATF6,Ap1,CYP,NFE2L2,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SREBF1,STAT3,TP53,acetaminophen,arachidonic acid,benzo(a)pyrene,carbon monoxide	
P1	 	GCLC	-0.155	enzyme	 	1.982	bias	-0.501	 	3.28E-04	FOS,JUN,JUNB,SLC39A8	FOXO1,GCLC,Growth hormone,HIF1A,Insulin,NFKB1,NFkB (complex),NR3C2,PPARA,PPARG,buthionine sulfoximine	
P1	 	HS6ST2	-0.058	enzyme	 	-0.141	bias	0.501	 	3.28E-04	CXCL8,FGF2,IL6,TPSAB1/TPSB2	CREBBP,ERK1/2,FGFR1,HS6ST2,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,estrogen receptor	
P1	 	OLFM2	1.707	other	 	-1.279	bias	0.251	-1.773	3.28E-04	ACTA1,HEY2,MYH11,TAGLN	ELK1,FOS,MKL1,MKL2,OLFM2,SRF	
P1	 	PD 180970	 	chemical - kinase inhibitor	 	-0.132	bias	-0.501	 	3.28E-04	BCL2L1,CCND2,MCL1,MYC	Ap1,CEBPA,CEBPB,GAB2,KIT,NFkB (complex),PD 180970,RELA,STAT,STAT1,STAT3,STAT4,STAT5a/b,TP53	
P1	 	MITF	0.351	transcription regulator	Activated	4.669	bias	0.450	1.584	3.30E-04	ACO2,ACP5,ALCAM,AMDHD2,APEX2,APOE,APOLD1,ATP6V1B2,BIRC7,CCNG2,CHTF18,CLCN7,COL1A1,CTSG,CTSK,CXCL8,FAM53B,FANCG,FOS,GM2A,GPM6B,GPNMB,GYG2,HIF1A,HMBS,ITGA3,KAZN,KIT,LIG1,MBP,MCM2,MGAT4B,MGP,NDST2,NPM3,PIR,POLD1,RAD51D,RRAGD,SEMA3C,SEMA6A,SLC7A8,SOX9,ST3GAL6,STXBP1,TBC1D16,TNFRSF14,TPSAB1/TPSB2,UPP1,UVRAG,VAT1	Ap1,HDAC1,IRF8,JUN,MITF,SPI1,TP53	
P1	 	HDAC2	0.262	transcription regulator	 	0.209	 	0.029	0.070	3.38E-04	ATG7,CCNG2,CD4,COL11A1,COL1A2,COMP,CXCL8,DPT,EGR1,ESR1,FAM107A,GABARAPL1,IL6,LHCGR,LIG1,MMP9,MYC,MYCN,NFKBIA,POLD2,PTGS2,RHOB,RRM2B,S100A9,SDPR,SFRP1,SOX9,SQSTM1,TAGLN,TNFRSF19,TNFSF10	Ap1,CEBPA,CEBPB,ESR1,HDAC1,HDAC2,HIF1A,Hdac,Histone h3,Histone h4,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SIN3A,SP1,STAT1,STAT3,TP53,histone deacetylase,vorinostat	
P1	 	LIPE	-0.589	enzyme	 	-0.543	 	0.114	-0.935	3.38E-04	ADH1C,ADIPOQ,ALDH1A1,ANGPT1,ATF3,CD36,CDO1,COL1A1,COL1A2,EDN1,EGR1,FOS,G0S2,GAPDH,H3F3A/H3F3B,HSPA1A/HSPA1B,MAPKAPK2,MEOX2,NET1,PC,PDK4,PFKFB1,PHKG1,PLIN2,RARA,RBP4,RGS5,SDC4,SMAD7,SUCLA2,THRSP	Ap1,CAV1,CEBPA,CEBPB,Creb,FOS,Ins1,JUN,LDL,LEP,LIPE,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,RNA polymerase II,SIRT1,SMAD3,SREBF1,STAT3,TP53,fatty acid	
P1	 	Ras	 	group	 	-1.024	bias	0.308	-2.316	3.38E-04	ARG2,ARHGEF2,BCL2L1,CAV1,CCL2,CCND3,CDKN2B,CSF3R,CTGF,CXCL8,EDN1,EGR1,FOS,HMGA1,HMOX1,JUN,LDLR,MMP2,MMP9,MYC,MYH11,ODC1,PDCD4,PLAUR,PTGS2,PVR,RAE1,SERPINE2,SIN3B,TFPI2,UPP1	Ap1,CREB1,EGR1,ERK,ERK1/2,ESR1,FOS,JUN,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,Ras,SMAD3,SP1,STAT3,TP53	
P1	 	ELK4	0.166	transcription regulator	 	 	 	 	 	3.38E-04	CCT8,EGR1,EGR2,EGR3,FOS,JUNB,NCOA7	Ap1,ELK1,ELK4,ESR2,FOS,JUN,MKL1,MKL2,NFkB (complex),SP1,SRF	
P1	 	NELFB	0.820	other	 	1.134	 	-0.084	1.355	3.38E-04	ATF3,COL6A1,CTGF,GADD45A,GADD45B,MKNK2,RPLP0	EP300,JUN,NELFB,NFkB (complex),NR3C1,RELA,STAT1	
P1	 	butyric acid	 	chemical - endogenous mammalian	 	-0.937	 	0.049	-1.309	3.42E-04	ACP2,ADCY1,ADGRG1,ALAD,ALDH1A1,ANXA5,ARID4A,BCL2L1,C7,CBS/CBSL,CCND2,CCR1,CD86,CDC16,CDC20,CDK4,CDKN1C,CLCN3,COL11A1,COL5A1,COL5A2,COL6A3,CPA3,CXCL8,CXCR4,DHCR24,DUSP1,ELANE,EMP3,ERCC2,FOS,FTH1,FYN,G0S2,GAA,GADD45A,GDI1,GRN,H2AFZ,HDGF,HIST1H1C,HK1,HLA-DRB1,IFNAR2,IGFBP3,IL6,ITGAM,ITPR2,JCHAIN,KIT,KLF4,LEP,LY6E,MCL1,MT2A,MYC,MYCN,NCL,NDUFAF4,NEU1,NFKBIA,NME1,NRP1,PCMT1,PFKL,PLAT,PRKCD,PTGDS,PTGS2,S100P,SGK1,SMPD1,SOCS3,SOX9,SPP1,TFF3,TGFBR2,TGM2,THBS4,THRA,TIMP1,TNFRSF10B,TPR	Ap1,ERK1/2,HIF1A,IL6,JUN,Jnk,MAX,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,TP53,butyric acid	
P1	 	ATP7B	-0.292	transporter	Activated	2.138	 	0.068	1.885	3.43E-04	ACLY,CDC20,CYP51A1,ELOVL6,H19,HIST1H1C,HMGCS1,LDLR,LPIN1,LSS,MSMO1,PTTG1,SQLE,THRSP	 	
P1	 	1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate	 	chemical - kinase inhibitor	 	-0.115	 	-0.056	0.020	3.45E-04	CXCL16,GDF15,IL6,MMP2,MT2A,PTGS2	1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate,Akt,Ap1,CREBBP,CTNNB1,Creb,EP300,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TP53	
P1	 	RUNX1T1	-0.162	transcription regulator	 	 	 	 	 	3.45E-04	CCL3,CCND2,CD69,CSF1R,ELANE,SPI1	CEBPA,CEBPB,CTNNB1,HDAC1,HDAC2,JUN,NFkB (complex),PPARG,RNA polymerase II,RUNX1T1,SIN3A,SP1,TP53	
P1	 	aurothioglucose	 	chemical drug	 	-0.059	 	0.056	-0.193	3.45E-04	HMOX1,LEP,LEPR,NQO1,POMC,SPARC	HIF1A,NFKBIA,NFkB (complex),RELA,STAT3,aurothioglucose,reactive oxygen species	
P1	 	desoxycorticosterone	 	chemical - endogenous mammalian	 	-0.167	bias	0.376	-0.994	3.45E-04	CTGF,CYBA,FOS,NOX4,PTGS2,SPP1	CREB1,EP300,FOS,JUN,NFkB (complex),NR3C1,NR3C2,Nfat (family),Pkc(s),RELA,STAT1,STAT3,desoxycorticosterone	
P1	 	nickel chloride	 	chemical toxicant	 	-0.889	bias	0.501	 	3.45E-04	CCL2,GAPDH,HIF1A,IL6,NDRG1,PTGS2	Akt,Ap1,HIF1A,IKBKB,JUN,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PI3K (complex),RELA,SP1,STAT3,TP53,nickel chloride	
P1	 	omeprazole	 	chemical drug	 	0.068	 	0.029	0.010	3.52E-04	ABCC3,ADORA1,AGT,BCL2L1,CD36,CELF2,CNN1,CTGF,CXCL12,CXCR4,EGR1,EPAS1,FOS,FST,HDC,POR	 	
P1	 	PRKCD	-0.676	kinase	 	1.311	 	0.218	0.270	3.55E-04	BCL2L1,BIRC3,CCL2,CD68,COL1A1,COL1A2,CXCL12,CXCL16,CXCL8,FOS,GDF15,IL6,ITGAM,JCHAIN,JUN,JUNB,MMP2,MMP9,MYC,NFKBIA,ODC1,PDCD4,PTGS2,TUBB2A,VCAM1,ZFP36	Ap1,ERK,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PRKCD,RELA,SMAD3,SP1,STAT3	
P1	 	E. coli lipopolysaccharide	 	chemical - endogenous non-mammalian	 	-1.818	bias	0.457	-3.813	3.65E-04	ATG7,BCL2L1,CCL2,CCL3,CCL8,CD86,CEBPD,CXCL2,CXCL8,CYR61,HSPA5,IL6,LY96,MMP9,S100A8,S100A9,SELE,SOCS3,TF,VCAM1	Ap1,CEBPB,E. coli lipopolysaccharide,IL10,IL17A,JUN,Jnk,NFATC2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TLR4	
P1	 	ADCY	 	group	 	0.841	bias	0.324	-0.062	3.69E-04	CDH2,COL3A1,CRYM,CYP1B1,FGF2,FOS,LEP,NR4A2,TXN	ADCY,Akt,CEBPB,CREB1,Creb,FOS,HIF1A,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),Pka,RELA,STAT1,STAT3,TP53,adenosine,cyclic AMP	
P1	 	PS-1145	 	chemical - kinase inhibitor	Activated	2.359	 	-0.238	3.062	3.69E-04	CCL2,CDK4,CXCL8,HSPA5,IL6,NFKBIA,PTGS2,SERPINA3,TNFAIP3	CCL5,CREB1,CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PS-1145,RELA,RNA polymerase II,STAT1,STAT3,TERT,TP53	
P1	 	resolvin D1	 	chemical - endogenous mammalian	 	1.866	 	-0.132	2.249	3.69E-04	ADIPOQ,CCL2,CXCL2,CXCL8,CXCR4,HMOX1,IL6,JUN,PTGS2	Akt,EP300,ERK1/2,HIF1A,HMOX1,JUN,MAP3K7,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RCAN1,RELA,SMAD3,SP1,STAT3,TP53,resolvin D1	
P1	 	MKL1	0.227	transcription regulator	 	-1.574	 	-0.121	-1.031	3.71E-04	ACTA1,BCL2L1,CDC42EP2,CNN1,CNN2,COMT,CPA3,CTSG,CXCR4,CYBA,DHCR24,DNAJB4,EGR1,ELANE,ELOVL3,ETV6,EYA2,FLNA,FOS,G0S2,GSTM5,MMP9,MYH11,MYLK,OSCP1,RUNX1,S100A8,S100A9,SLC20A1,TAGLN,WAS,ZFPM1	Akt,ELK1,FOS,HIF1A,JUN,MKL1,MKL2,NFkB (complex),RELA,Ras,SP1,SRF,STAT1,STAT3,TP53	
P1	 	MYD88	-0.316	other	 	-0.718	bias	0.440	-3.749	3.73E-04	ALDH1A1,ALDH1A2,ATF6,ATP6V1E1,BAMBI,CASP4,CCL2,CCL3L3,CD14,CD86,CEBPD,CH25H,CLEC10A,CTSK,CXCL12,CXCL2,CXCL8,CYR61,DUSP1,EGR1,ETS2,FOS,GDF15,HDC,HIF1A,HMOX1,HP,HSPA5,IFIT2,IL6,ITPR2,JUN,LPAR1,MARCO,MCM2,MMP2,MMP9,MYC,NFKBIA,NFKBIZ,PLA2G4A,PTGS2,S100A8,SAA1,SELE,SLC7A2,SOCS3,SPP1,TIMP1,TNFAIP3,TSC22D1,VCAM1	Ap1,CHUK,IL1B,JUN,Jnk,MYD88,NFATC2,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TLR4	
P1	 	Notch	 	group	Inhibited	-2.152	bias	0.251	-3.172	3.73E-04	ADM,AGT,CCND3,CDKN2B,DUSP1,GADD45B,GUCY1A3,HEY1,HEY2,HEYL,ID1,ID3,IL6,MCL1,MMP2,MYC,MYLK,NET1,NOTCH1,SMAD6,TAGLN	Akt,Ap1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,Notch,PI3K (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TNF,TP53	
P1	 	ST1926	 	chemical drug	Inhibited	-4.867	bias	-0.483	-1.890	3.75E-04	AK2,AKR1B1,AP2M1,AP2S1,ARSA,ATP5I,CCT3,CDK4,COX7A2L,ENO1,H2AFZ,ITGA11,KPNA2,MAN1B1,MTCH2,NARS,NDUFB9,NME1,ODC1,PCBP2,PFN1,PIN1,POLR2G,PSMA4,RPL6,RPL8,RPLP1,RPS2,S100P,SLC25A6,SLC38A7,SNRPB,SRSF3,TIMM8B,TNFRSF10B,TXN,UBE2M,UQCRH	 	
P1	 	SB-431542	 	chemical reagent	 	0.000	 	-0.188	0.876	3.76E-04	ATP1A2,BMP4,BMP6,C5AR1,CD14,COL1A1,CTGF,DVL3,ETS2,FOLR2,FOS,GADD45B,GJB2,ID1,KCNJ8,MMP2,MYC,PTPRK,SMAD6,SMAD7,SPP1,TJP1,TNFRSF12A	CEBPB,CREB1,ESR1,ESR2,FOS,FSH,JUN,MAPK1,NFKB2,NFkB (complex),PGR,RELA,SB-431542,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,beta-estradiol,progesterone	
P1	 	chenodeoxycholic acid	 	chemical - endogenous mammalian	 	0.272	 	0.138	-0.358	3.76E-04	ABCC3,ABCG1,AGT,APOB,APOE,CAV1,CD36,COL1A1,CXCL8,CYP27A1,EGR1,ERBB2,FBP1,IL6,LDLR,MMP9,NR5A2,PCK2,PDK4,PLTP,PTGS2,TNFRSF10B,TXNRD1	CREBBP,EP300,ERBB2,ERK1/2,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SMAD3,SP1,STAT1,STAT3,TP53,chenodeoxycholic acid,estrogen receptor	
P1	 	mir-24	-0.029	microrna	 	-0.664	bias	-0.258	0.251	3.78E-04	CCND3,CDH2,CDK4,CDKN2B,FAF1,IL6,KDR,MYC,NET1,PAK4,SH3PXD2A,SPRY2,TRIB3	ERK1/2,IL6,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,mir-24	
P1	 	MAPK8	-0.045	kinase	 	0.161	bias	0.253	-1.217	3.80E-04	ACSL4,APOE,ATG7,BIRC3,BMP4,CDH2,COL1A1,CSTA,CXCL16,CXCL8,CYP11A1,CYP27A1,DUSP1,EGR1,ELK1,ETS1,FOS,FTH1,GSTM1,HMOX1,IL6,JUN,KLF6,MIF,MMP2,MMP9,MYC,NOX4,NUPR1,PLAUR,PTGS2,PTX3,RARA,SELE,TNFAIP3,ZFP36	Ap1,FOS,JUN,Jnk,MAPK8,MAPK9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF	
P1	 	sulforafan	 	chemical drug	 	1.375	 	-0.005	1.398	3.93E-04	AKR1B1,AKR1B10,ALDH1A1,AOX1,BCL2L1,CCL2,CXCL8,EPHX1,FOS,GCLM,GSR,GSTM1,GSTM5,GSTT1,HIF1A,HMOX1,HP,IL6,KEAP1,LIPE,MMP9,NFKBIA,NQO1,PSMB5,PTGS2,SELE,SOCS3,TALDO1,TNFRSF10B,TXNRD1,VCAM1	Ap1,BACH1,IKBKB,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53,sulforafan	
P1	 	TGFBR2	-0.563	kinase	 	-0.829	 	0.068	-1.182	4.00E-04	ACSL3,ANGPTL4,ATF4,ATP1A2,BMP6,C5AR1,CCND3,CCT5,CD14,CDH2,CDKN2B,COL1A1,COL1A2,CTGF,CXCL2,DSG2,FST,GADD45B,GJB2,IL6,ING1,JUN,KCNJ8,KDR,KRT8,MMP2,MMP9,MYOF,NIPA2,NRP1,SLC2A3,SMAD7,SOCS3,SPARC,SPP1,SVEP1,TAGLN,TGFBR2,THBD,THBS1,TIMP1,TNFRSF12A	Ap1,CEBPA,CEBPB,IFNG,JUN,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TGFB1,TGFBR2,TP53,Tgf beta	
P1	 	SRC (family)	 	group	 	-0.850	bias	0.272	-1.733	4.06E-04	BMP2,CCL2,CD36,CDKN1C,HIF1A,ID1,IL6,KLF2,MAOA,MCL1,PTGS2,SLC4A7,TJP1,VCAM1,VEGFC	Akt,CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,PI3K (family),RELA,SIRT1,SP1,SRC (family),STAT3,TP53,Vegf	
P1	 	brefeldin A	 	chemical - endogenous non-mammalian	 	0.716	 	0.023	0.629	4.06E-04	ADRA1B,ATP2A2,DDIT3,GADD45B,HMOX1,HSPA5,HSPA9,KCND2,KLF4,LONP1,PRNP,PTGS2,SESN2,STARD5,THBS1	ATF6,Creb,DDIT3,EIF2AK3,FOXO1,FOXO3,HIF1A,IL6,NFE2L2,NFKBIA,NFkB (complex),RELA,SP1,SREBF2,STAT1,STAT3,TP53,brefeldin A,cholesterol,reactive oxygen species	
P1	 	ELANE	0.552	peptidase	 	-1.658	 	0.234	-2.422	4.06E-04	CCL3L3,CD14,CTSB,CXCL2,CXCL8,ELANE,ELN,FOS,HSPA5,IL6,MMP2,MMP9	Ap1,ELANE,ERK1/2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SMAD4,SP1,STAT1,STAT3,TP53,Tgf beta	
P1	 	SHC1	0.878	other	 	1.492	 	0.072	1.275	4.06E-04	BCL2L1,CD69,FOS,FTH1,ITGAM,KLF2,NQO1,S1PR1,SELE,SQSTM1,THBD,TXN	APP,Ap1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SHC1,SP1,STAT1,STAT3	
P1	 	semaxinib	 	chemical drug	 	-0.263	 	-0.167	0.203	4.06E-04	CD24,FHL1,HIF1A,HMOX1,IL6,KDR,MMP9,PTGIS,PTGS2,S100P,SELE,THBS1	AKT1,EDN1,EP300,ERK1/2,HIF1A,JUN,KIT,NADPH oxidase,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT,STAT1,STAT3,STAT4,STAT5a/b,TP53,semaxinib	
P1	 	EGR2	-1.750	transcription regulator	 	-0.512	bias	0.440	-2.861	4.07E-04	ABCC1,ASS1,BNIP3L,CAST,COL11A1,CSF1R,CYP51A1,DHCR7,EGR1,EGR2,ERBB2,FCER2,FGF2,FOS,HSPA5,ID4,JUN,KDR,LAMA2,MBP,MME,NCL,NOTCH1,NSF,PMP22,PRKCD,S100A1,SLC12A2,SLC1A3,SOCS3,SQLE,TFRC,TGFBR3,TNFSF10,TXNRD2	CEBPA,CEBPB,EGR2,IFNG,IL10,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53	
P1	 	ALDH2	-0.875	enzyme	Inhibited	-3.148	bias	-0.501	 	4.11E-04	ATF4,ATF5,GCLM,GSS,MTHFD2,PSAT1,SHMT2,SLC1A4,SLC3A2,SLC7A5	 	
P1	 	MAP3K3	-0.187	kinase	 	-1.476	bias	0.501	 	4.11E-04	ACTA1,ADSSL1,BMP2,CXCL8,FOS,IL6,JUN,PSME3,TGFBR3,TNFAIP3	Ap1,FOS,IKBKG,JUN,MAP2K5,MAP3K3,MAPK8,MAPK9,NFE2L2,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3	
P1	 	PKM	1.610	kinase	 	1.711	bias	0.501	 	4.11E-04	ACLY,BCL2L1,CDH2,ENO1,MAP2K5,MMP2,MMP9,MYC,PKM,VEGFC	ARNT,CEBPA,CEBPB,CTNNB1,HDAC1,HDAC3,HIF1A,JUN,MAP2K1,MYC,NCOR2,NFE2L2,NFkB (complex),PKM,PPARG,RELA,SMAD3,SNAI1,SP1,STAT1,STAT3,TCF,TP53,VHL	
P1	 	benzene	 	chemical toxicant	 	-0.471	 	0.052	-0.691	4.18E-04	ACVR1C,ATF5,BCL2L1,COL1A1,COL3A1,DHCR24,EGR1,FBXO3,IGFBP3,LTBR,MAPKAPK2,NR2F6,PLS3,PTPRF,RHOB,RTN4,SPARC,STOM	 	
P1	 	trichloroethylene	 	chemical toxicant	 	-0.471	 	0.052	-0.691	4.18E-04	ACVR1C,ATF5,BCL2L1,COL1A1,COL3A1,DHCR24,EGR1,FBXO3,IGFBP3,LTBR,MAPKAPK2,NR2F6,PLS3,PTPRF,RHOB,RTN4,SPARC,STOM	 	
P1	 	ECSIT	0.048	transcription regulator	Inhibited	-2.739	bias	0.501	 	4.20E-04	CCL3L1,CXCL8,HMOX1,IER3,IL6,JUNB,NFKBIA,NR4A2,PLAUR,PTGS2,TNFAIP3	ATF2,ECSIT,FOS,HIF1A,JUN,MAP3K1,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3	
P1	 	PD 123319	 	chemical drug	 	0.798	 	-0.084	1.042	4.20E-04	CD24,COL1A1,CYBA,KDR,NCF2,POMC,PTGS2,RET,SPP1,SPRY1,TIMP1	AGT,AR,Ap1,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,PD 123319,PPARG,PRL,RELA,SMAD3,SP1,STAT1,STAT3,TP53,aldosterone	
P1	 	WR 1065	 	chemical drug	Activated	2.143	bias	0.464	0.617	4.20E-04	CASP4,CAT,ERCC1,GADD45A,GDF15,GSR,KDR,MYC,NME1,RAD23A,TNFRSF10B	Ap1,ERK1/2,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,TP73,WR 1065	
P1	 	APC	-0.018	enzyme	 	1.549	 	-0.106	1.949	4.23E-04	AMHR2,APCDD1,APOB,AXIN2,CD55,CDH2,CS,CXCL12,CXCL2,DHRS9,EDN1,HIF1A,ID1,ID3,IL6,KLF4,MYC,ODC1,PDK4,PLA2G4A,PTGS2,SGK1,SPP1,TFF3,TIMP1,TJP1	APC,CREBBP,CTNNB1,Creb,FOS,FOXO1,HDAC1,HIF1A,JUN,MTOR,NFKB1,NFkB (complex),RAC1,RELA,STAT1,STAT3,TCF	
P1	 	IL10	-0.067	cytokine	 	0.406	 	0.054	-0.019	4.27E-04	ADM,ARG2,BCL2L1,BMP2,BMP6,CCL18,CCL2,CCL3,CCL3L3,CCND2,CCND3,CCR1,CD14,CD163,CD163L1,CD209,CD55,CD68,CD86,CHI3L2,COL1A1,CSF1R,CTSB,CXCL12,CXCL2,CXCL8,CXCR4,DUSP1,ETS2,FAAH,FCER1G,FCER2,FCGR3A/FCGR3B,FLRT2,FOS,HCAR3,HLA-G,HMOX1,IDO1,IFIT2,IGFBP4,IL10RA,IL6,IRAK1,JUN,LAMP3,MAF,MAP3K8,MMP2,MMP9,MS4A2,NEDD9,NR4A3,PLA2G2A,PTGS2,PTX3,RARRES1,RGS16,S100A8,SELE,SLC1A3,SOCS3,TFRC,TIMP1,TINAGL1,TMEM158,TNFSF10,VCAM1,VCAN,ZFP36	IFNG,IL10,IL1B,IL4,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,STAT6,TNF	
P1	 	TFAP2A	0.122	transcription regulator	 	1.385	 	-0.077	1.657	4.36E-04	ALCAM,APOE,BCL2L1,BIRC3,COL7A1,CXCL2,CYP11A1,DCLK1,ERBB2,ESR1,FASTK,G3BP2,KLF4,KLHDC3,LHCGR,MMP2,MT2A,PAG1,PLAUR,POR,RPL6,RPLP0,SLC19A1,SMPD1,TPM1	Akt,Ap1,CTNNB1,EGR1,ESR1,HDAC1,HIF1A,JUN,NFkB (complex),RNA polymerase II,SMAD3,SP1,SP3,STAT3,TCF,TFAP2A,TP53	
P1	 	XBP1	0.122	transcription regulator	Activated	2.828	bias	0.431	0.194	4.43E-04	ATF6,ATP2A2,CAT,COPE,CXCL2,CXCL8,DDIT3,DDOST,DNAJB11,DNAJB2,DNAJC1,EDEM1,ERP29,ESR1,ETS1,FKBP2,GCC1,GOLGA3,HMOX1,HSPA13,HSPA5,HYOU1,IL6,KDELR3,KLF4,MYC,NUCB2,ORMDL3,P3H1,PHLDA2,PRNP,RCN3,RPN2,S1PR1,SDF2L1,SEC61A1,SELM,SPARC,SRPRA,SRPRB,STARD5,TXN,VCAM1,YIF1A,YIPF5	ATF6,Ap1,BACH1,Creb,DDIT3,ERK1/2,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,XBP1	
P1	 	NRAS	-0.030	enzyme	 	-1.079	 	0.240	-1.745	4.47E-04	BCL2L1,CCL3L1,CD86,CDC20,CDKN2B,COL1A2,EGR1,ELK1,EPAS1,ETS1,ETV5,FCER2,GALE,HIF1A,HOMER3,JCHAIN,KDR,MCL1,NCF2,POLD1,PTGS2,RHOB,SV2B,XPNPEP2	AKT1,Akt,Ap1,HIF1A,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),NRAS,PI3K (complex),RELA,SP1,SRF,STAT1,STAT3,TP53	
P1	 	NS-398	 	chemical reagent	 	0.771	bias	-0.310	2.081	4.55E-04	ANGPT1,BTG2,CAPN2,COL1A2,CXCL8,CXCR4,EGR2,FAT1,FGF2,HIF1A,IL6,MCL1,MMP2,MMP9,PCDH7,PDCD4,PSMB5,PTGS2,S100A8,S100A9,SPP1,TFPI2,TFRC	Ap1,ERK,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),NS-398,PPARG,PTGS2,RELA,SMAD3,SP1,STAT3,TP53,prostaglandin E2	
P1	 	DETA-NONOate	 	chemical reagent	 	-1.798	 	0.113	-2.237	4.57E-04	BCL2L1,BIRC3,CAT,CCL3,CXCL8,DUSP1,FOS,HIF1A,HMOX1,IL6,MMP9,PDE3B,PTGS2,S100A8,TIMP1,VCAM1	CAT,DETA-NONOate,ERK1/2,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	RARG	-0.015	ligand-dependent nuclear receptor	 	0.194	bias	0.274	-0.567	4.62E-04	BMP2,CRABP2,DUSP1,EGR1,EGR2,FOLR2,FOS,FOXC1,GAP43,IL6,JUN,MYC,RARA,THBD	Akt,Ap1,ESR2,FOS,HIF1A,JUN,NFkB (complex),RARB,RARG,RELA,SP1,STAT3,TP53,arotinoid acid,tretinoin	
P1	 	SQSTM1	0.761	transcription regulator	 	0.366	 	0.230	-0.409	4.62E-04	CXCL2,EDN1,GSTM5,HBEGF,IL6,JUN,KEAP1,LEP,NFKBIA,NQO1,PLAT,RGCC,RILPL1,TSC22D1	Ap1,ERK,HIF1A,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SQSTM1,STAT1,STAT3	
P1	 	Histone h4	 	group	 	 	 	 	 	4.65E-04	ACTA1,ADIPOQ,AGT,AKAP12,BTG3,CCND3,CD69,CDK4,CHFR,CXCL8,ESR1,FOS,G6PD,HOXA9,IL6,KIF1A,KLF2,MGMT,MMP9,NEDD4L,NLGN1,POLD2,PTGS2,SELE,SFRP1,SOCS3,SPP1,TACC2,TAGLN,TGFBR2,TNFRSF4,TNFSF10,VCAM1	Ap1,BCL2,CTNNB1,HDAC1,HDAC2,HIF1A,Hdac,Histone h4,IL1B,NFATC3,NFKB1,NFKBIA,NFkB (complex),RELA,SIN3A,SP1,STAT3,TP53	
P1	 	8-bromo-cAMP	 	chemical reagent	 	-0.749	bias	0.281	-2.474	4.69E-04	ACSL4,ADM,ALDH2,ARG2,BMP2,CTGF,CTSD,CYP11A1,CYP1B1,DUSP1,EGR1,FGF2,FOS,GNAI1,IL6,INHBB,ITPR2,JUN,KDR,KRT8,LDLR,LHCGR,LOX,MMP23B,MYC,NQO1,NRP1,ODC1,PDE3B,PLAT,POMC,PPP1R1A,PTGFR,PTGS2,SGK1,SHC1,SPP1,TGFBR3,TIMP1,VEGFC	8-bromo-cAMP,CEBPB,CREB1,Cg,FOS,FSH,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,cyclic AMP	
P1	 	SRF	-0.473	transcription regulator	Inhibited	-3.879	 	0.215	-5.043	4.76E-04	ACTA1,ACTG2,AKAP12,APOLD1,ARHGAP20,BCL2L1,BMP2,CAPRIN1,CDK4,CENPB,CLDN5,CNN1,CNN2,CPA3,CTGF,CTSG,CXCR4,DUSP5,EGR1,EGR2,EGR3,EIF6,ELANE,ELK1,ETS1,EYA2,FHL1,FLNA,FOS,FOSB,FST,G0S2,GSTM5,HES6,IER2,ITGA1,ITGAM,JUN,JUNB,KDR,LDLR,LEPR,LMCD1,MAP4K4,MBD2,MCL1,MMP9,MYH1,MYH11,MYL3,MYLK,MYOM1,NCOA7,NET1,NR4A2,OSCP1,PDLIM7,PTGS2,PTMS,RNH1,S100A8,S100A9,SCAP,TAGLN,TJP2,VEGFD	Ap1,ELK1,ESR2,FOS,HDAC2,Hdac,JUN,MKL1,MKL2,NFkB (complex),PTK2,SMAD3,SP1,SRF,STAT1,STAT3	
P1	 	CD24	-0.916	other	 	-1.579	bias	0.501	 	4.81E-04	ADRB2,ATF3,CAV1,CHAC1,CXCL8,DUSP5,EMP3,EPHB6,FOS,FRYL,GDF15,HOMER3,HS2ST1,ISG20,JUN,LPP,LRPPRC,MCAM,MTUS1,NAGK,PPP1R15A,RARRES1,TFPI2,THBS1,TIMP4,TPR,TUFT1	Ap1,CD24,CEBPA,CEBPB,ELK1,ERK,FOS,JUN,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	FLI1	-0.262	transcription regulator	 	-0.613	bias	0.301	-1.670	4.98E-04	ADGRG1,CCND3,COL1A1,COL1A2,CSF1R,CTGF,EGR1,HSPA8,IMP4,LOX,NOL6,SNRPB,SNU13,SRC,SRGN,TEK,TGFBR2	FLI1,GATA1,MYB,SPI1,STAT1,STAT3,STAT5a/b	
P1	 	MAP3K1	-0.161	kinase	 	-1.739	bias	0.361	-3.197	4.98E-04	ATF3,BIRC3,COL3A1,CSTA,CXCL8,DUSP1,EGR1,FOS,HMOX1,IRF3,JUN,LDLR,PLA2G4A,PLAUR,PTGS2,THBS1,TIMP1	Ap1,CEBPB,ELK1,FOS,JUN,MAP2K1,MAP3K1,MAPK3,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3	
P1	 	hydrogen sulfide	 	chemical - endogenous mammalian	 	1.313	bias	0.301	0.479	5.00E-04	BCL2L1,CD69,CXCL8,DDIT3,HMOX1,HSPA5,PTGS2,TXN	Ap1,BACH1,HIF1A,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PRKCE,RELA,SP1,STAT1,STAT3,hydrogen sulfide	
P1	 	bisindolylmaleimide I	 	chemical - kinase inhibitor	 	0.658	bias	-0.420	2.761	5.01E-04	AGT,BCL2L1,BIRC3,CCND2,CD55,CTGF,CXCL8,EGR1,EIF4EBP1,FOS,GAP43,GDF15,HMOX1,HSPA5,IL6,MMP2,MMP9,NFKBIA,PDCD4,PRKCD,PRKCE,PTGDS,PTGS2,TJP1,TJP2,TNFSF10	Ap1,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,PRKCE,RELA,SP1,SRC,STAT1,STAT3,bisindolylmaleimide I	
P1	 	nitric oxide	 	chemical - endogenous mammalian	 	0.620	 	0.178	-0.341	5.23E-04	ATF3,BCL2L1,CTGF,CTSH,CXCL12,CXCL8,DDIT3,DUSP1,EDN1,EGR1,FOS,FTH1,GADD45A,GCLM,GSTM1,HEY1,HMOX1,IDO1,IER3,IL6,JUN,JUNB,MMP2,MMP9,MYC,NDRG1,NQO1,ODC1,PRDX5,PTGS2,SELE,SGK1,SPP1,SQSTM1,TFRC,THBS1,TXNRD1	Ap1,D-glucose,ERK,ESR1,HIF1A,JUN,MYC,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PPARG,RELA,SMAD3,STAT3,nitric oxide	
P1	 	FMR1	0.113	translation regulator	Inhibited	-2.593	bias	-0.365	-1.253	5.33E-04	ALDOA,ATP6V1E1,ATPIF1,DLG4,ENO1,GAP43,GAPDH,KCND2,MAP1B,MMP9,MTOR,PCLO,PLAT,SYN1,TSC2	AR,DICER1,FMR1,FOS,FOXO1,HIF1A,MTOR,NFKB1,NR3C1,SPI1,STAT1,STAT3,TP53	
P1	 	TICAM1	-0.070	other	 	-1.838	bias	0.470	-4.401	5.35E-04	ATP6V1E1,CASP4,CCL2,CCL3L3,CD86,CEBPD,CFB,CH25H,CXCL2,CXCL8,DUSP1,EGR1,ETS2,GDF15,IFIT2,IL6,IRF3,ISG20,ITPR2,LPAR1,MCM2,NFKBIA,NFKBIZ,PELI1,PTGS2,RHOB,SELE,SLC7A2,SOCS3,TNFAIP3,TNFSF10,TSC22D1,VCAM1	Ap1,IL1B,JUN,MYD88,NFATC2,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TICAM1,TLR4	
P1	 	arachidonic acid	 	chemical - endogenous mammalian	 	-1.027	 	0.112	-1.554	5.35E-04	ACACA,ACSL4,CD36,CD86,COL1A2,EDN1,EGR1,ELOVL6,FOS,G6PD,HMOX1,IL6,JUN,KDR,LDLR,NFKBIA,PLA2G2A,PLA2G4A,PLTP,PTGS2,SRSF3,THRSP,UCP2,VCAM1	Ap1,FOXO1,Growth hormone,HIF1A,IL6,Insulin,JUN,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT1,STAT3,arachidonic acid,linoleic acid	
P1	 	allopurinol	 	chemical drug	 	1.504	bias	0.310	0.019	5.48E-04	ADAMTS1,ASNS,BIRC3,CAPN6,CAT,CD14,CD69,EFEMP2,EMP3,GPNMB,GSTM3,HMOX1,IER3,LXN,MYC,PSMB10,PTGS2,RCN1,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	Akt,ERK,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TP53,allopurinol,reactive oxygen species	
P1	 	MYOCD	-0.085	transcription regulator	Inhibited	-2.732	bias	0.280	-3.974	5.56E-04	ACTA1,ATF4,ATP2A2,CASQ2,CLSTN2,CNN1,COL1A1,COL1A2,COL3A1,DDIT3,ECM2,FOS,HSPB7,LOC102724428/SIK1,LPP,MYH11,MYLK,PLA2G2A,PTPRB,TAGLN,TPM1,VCAN	ELK1,FOS,MKL1,MKL2,MYOCD,SRF	
P1	 	TLR4	-0.002	transmembrane receptor	 	-1.951	bias	0.371	-4.411	5.57E-04	ACTA1,ADM,ADRBK1,ATF3,ATF6,BAMBI,BCL2L1,CAST,CCL2,CCL3,CCL3L3,CCL8,CCND2,CD14,CD163,CD86,CEBPD,CERS6,CFB,CTSK,CXCL2,CXCL8,CYR61,DAB2,EDN1,HBEGF,HDC,HMOX1,HSPA5,IFIT2,IL6,IRF3,ISG20,ITGAM,LMO4,LRRK2,MARCO,METTL1,MIF,MMP9,MYC,NFKBIA,NFKBIZ,NOTCH1,NR4A2,NR4A3,NSMAF,ORMDL3,PELI1,PLAT,PTGS2,RGCC,RGS1,RGS16,RILPL1,SELE,SGPL1,SMPD1,SMPDL3A,SOCS3,SPP1,SPTLC2,TFRC,TNFAIP3,TNFSF10,TPM1,TSC22D1,VCAM1	Ap1,Creb,JUN,MAPKAPK2,MYD88,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TICAM1,TLR4,TP53,ZFP36,lipopolysaccharide	
P1	 	WNT5A	-0.100	cytokine	 	0.602	 	0.066	0.277	5.66E-04	AXIN2,BCL2L1,BMP6,CCL2,CCL3L3,CD14,COL1A1,CXCL12,CXCL2,CXCL8,CXCR4,DAB2,DOK2,ENPP2,ERBB2,FLNA,ID3,IL6,KIT,MYC,PTGS2,RET,SOCS3,SPARC,SPP1,STC1,TNFSF10	IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,WNT5A	
P1	 	8-bromoguanosine 3',5'-cyclic monophosphate	 	chemical - kinase inhibitor	 	1.194	 	0.157	0.659	5.70E-04	ACACA,CAV1,EDN1,FOS,HINT1,HLCS,HMOX1,ITGAM,JUNB,MMP9,PLAUR,VCAM1	8-bromoguanosine 3',5'-cyclic monophosphate,ATF4,E2F1,EDN1,EGR1,ERK,ERK1/2,FOXO1,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SIRT1,SMAD3,SP1,STAT3	
P1	 	GAB2	0.168	other	 	-1.482	bias	0.340	-2.639	5.70E-04	ANGPT1,BCL2L1,CCL3L3,CD69,ELK1,FOS,HIF1A,IL6,KDR,MCL1,SMAD7,SPARC	AKT1,Akt,GAB2,HIF1A,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1,STAT3,TP53	
P1	 	thalidomide	 	chemical drug	 	0.326	bias	-0.468	1.908	5.70E-04	ANGPT1,BCL2L1,BIRC3,CAV1,COL1A1,CXCL8,FGF2,GADD45B,GDF15,IL6,ITGAM,PLAUR	ERK1/2,FN1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TNF,thalidomide	
P1	 	cadmium chloride	 	chemical toxicant	 	1.277	 	0.234	0.633	5.90E-04	ANXA5,ATF4,DDIT3,FOS,GADD45A,GSR,GSTM1,HMOX1,HP,HSPA13,HSPA5,IGFBP6,JUN,LPAR1,MYC,TXN	Ap1,BACH1,ESR1,ESR2,FOS,JUN,MAPK8,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,beta-estradiol,cadmium chloride	
P1	 	fluocinolone acetonide	 	chemical drug	 	-1.000	 	-0.075	-0.701	5.90E-04	ANGPTL4,ANOS1,BCL2L1,HSD11B2,ITGA10,LIMCH1,LSP1,MT1E,MT1F,MT1X,MXRA5,MYOC,PIR,RGCC,SAA1,SOCS3	 	
P1	 	HRG	0.045	other	 	0.333	bias	0.501	 	5.91E-04	C1QA,C1QB,C1QC,CXCL14,CXCR4,FCGR3A/FCGR3B,SPARC,SPP1,TIMP1	 	
P1	 	IGF2BP1	0.038	translation regulator	Activated	2.333	bias	0.451	0.979	5.91E-04	CDC34,COL1A1,COL1A2,COL5A1,COL6A2,COL6A3,LUM,MYC,SERPINH1	 	
P1	 	PD184352	 	chemical drug	 	0.849	 	-0.125	1.150	5.91E-04	BCL2L1,EGR1,ESR1,FOS,HSPA5,MCL1,NELFB,PPP1R14B,TRMT112	AKT1,ELK1,ERK1/2,FOS,JUN,MAPK3,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD184352,RELA,SMAD3,SP1,SRF,STAT1,STAT3,TP53	
P1	 	S100A9	-1.518	other	 	-1.167	 	0.145	-2.028	5.93E-04	ABCG1,ADAMTS1,AKAP12,ALDH1A1,ALPL,ATF3,BACE2,BMF,C1QB,CHDH,CXCL14,CXCL8,DDIT4,ELN,ENPP2,EPB41L4B,ETV5,GJB2,H19,HEY2,IL6,ITGAM,KCNMA1,LOC102724788/PRODH,MGMT,MYH1,NR4A3,NTRK3,PHLDA1,S100A8,S100A9,SEMA3B,SGK1,TNFAIP8,TNFRSF4,VCAM1,VCAN	APP,CREB1,Ca2+,ERK1/2,HIF1A,IL6,NFKB1,NFKBIA,NFkB (complex),RELA,S100A8,S100A9,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	STK11	0.435	kinase	 	-1.300	 	-0.039	-1.070	5.93E-04	ACP6,ALCAM,ARF5,ASPHD2,ATF3,CCL18,CCL2,CSF3R,DIABLO,ECM2,GADD45A,GADD45B,HIF1A,IL6,JUNB,LUM,MCAM,MMP2,MMP9,MRPS15,MYC,NEDD9,NET1,NPTX2,NR1D1,PSMB5,PTGS2,PTPN3,RGS1,RND2,SERPINI1,SORL1,TARS,TNFAIP3,TNFSF10,TTYH1,VAV3	ATF2,EGFR,GSK3B,HIF1A,IL6,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STK11,TNF	
P1	 	gefitinib	 	chemical drug	 	1.491	 	-0.186	2.099	6.07E-04	ADAMTS1,ALDH1A1,BMF,BTG2,CCL2,CEBPD,CHEK2,COL15A1,COL1A1,COL8A1,CTSA,CTSB,CXCL8,EGR3,FMO2,GADD45B,HMOX1,HYAL1,ID1,ID4,KIT,MAP4K4,MYCN,NOTCH1,NOX4,PLAUR,PTGS2,PTTG1,RHOB,S100A9,SLC2A3,TNFRSF10B,TNFSF10,VEGFD,WNT5B	ATF2,EGFR,ERBB2,ERK,ERK1/2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SRC,STAT3,TP53,estrogen receptor,gefitinib	
P1	 	SIAH2	0.741	transcription regulator	 	1.086	 	0.137	0.814	6.08E-04	AKR1C3,ANGPT1,DDT,DHCR24,HIF1A,MME,MT1X,NDRG1,PMEPA1,SCAP,SIAH2	AR,NCOR1,NCOR2,NR3C1,PPARA,PPARG,SIAH2,SP1,STAT3,THRB,TP53	
P1	 	RCE1	0.677	peptidase	 	 	 	 	 	6.16E-04	AEBP1,CRABP1,CRIP1,CXCL12,GPC4,HBEGF,LARGE1,LMNA,MGP,PLIN2,RCE1,RCN1,SERINC1,SLIT3	 	
P1	 	emodin	 	chemical drug	 	-1.126	bias	-0.251	-0.354	6.16E-04	ABCC1,ADIPOQ,CCR1,CLDN5,CXCL8,CXCR4,CYP1B1,ERBB2,ERCC1,HSPA5,LEP,MMP9,SELE,VCAM1	Ap1,EGR1,ESR1,JUN,Jnk,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PPARG,RELA,STAT3,TP53,emodin,troglitazone	
P1	 	fasudil	 	chemical drug	 	0.196	 	-0.223	0.989	6.16E-04	BCL2L1,BMP2,CCL2,CD14,CTGF,IL6,JUN,MIF,MMP2,MMP9,MYH11,SLC1A3,TAGLN,VCAM1	HIF1A,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TNF,fasudil	
P1	 	deoxycorticosterone acetate	 	chemical drug	 	1.989	bias	0.251	1.214	6.20E-04	CD68,COL3A1,CYBA,EDN1,MYH11,PTGS2,SELE,SLC9A1,SPP1,VCAM1	CREB1,CTNNB1,NFKBIA,NFkB (complex),PIK3R1,TP53,deoxycorticosterone acetate	
P1	 	diphenyleneiodonium	 	chemical reagent	 	0.662	bias	-0.410	2.319	6.31E-04	AGT,BMP2,CCL2,COL1A1,CXCL2,CXCL8,EPAS1,FOS,HIF1A,HMOX1,IL6,MMP9,NOX4,PTGS2,SELE,TIMP1,UCP2	Akt,Ap1,CEBPA,CEBPB,ERK,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53,diphenyleneiodonium	
P1	 	EPO	0.161	cytokine	 	-0.367	bias	0.257	-1.915	6.34E-04	ALAS2,ATP6V1B2,BCL2L1,BNIP3L,BTG1,BZW2,CCND2,CCND3,CCNG2,CD36,CLGN,CPSF3,CTSK,CXCL12,CXCR4,DDIT3,DHCR24,EDN1,EGR1,FECH,FGF2,FOS,FOSB,GBA,GLUL,GSPT1,H2AFZ,HLA-DRB1,IL6,JUN,JUNB,KAT2B,KIT,KPNA2,LDLR,LY6E,MCL1,MID1IP1,MMP2,MYC,NFKBIA,NUPR1,PDCD4,PRKCD,PTGS2,PTPRB,RPLP0,SELE,SOCS2,SOCS3,SPP1,ST3GAL4,TF,TFRC,TJP1,TNFSF10,UCP2,VEGFC	Ap1,EPO,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF,nitric oxide	
P1	 	LDLR	0.611	transporter	 	1.620	 	-0.096	1.900	6.38E-04	ABCG1,ALCAM,APOB,APOE,AXIN2,BMP2,CD36,CD68,CYP27A1,DDIT3,EGR1,G6PD,GJA4,HSPA5,IL6,LDLR,MMP2,MMP9,MYC,PSMB7,PSME2,SELE,SPP1,VCAM1	APOE,Ap1,CREB1,CREM,CTNNB1,IgG,JUN,LDL,LDLR,LEP,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,SREBF2,STAT3,cholesterol	
P1	 	BMX	-0.457	kinase	 	-0.359	bias	0.424	-1.473	6.47E-04	COL3A1,CXCL8,FOS,HSPA1A/HSPA1B,IL6,MMP2,TIMP1	Akt,Ap1,BMX,CEBPA,CEBPB,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,RHOA,STAT1,STAT3,TP53	
P1	 	GNA13	0.323	enzyme	Inhibited	-2.226	bias	0.501	 	6.47E-04	CNN1,CXCL8,EGR1,FOS,MYH11,PTGS2,TAGLN	ATF2,Ap1,ELK1,FOS,GNA13,JUN,Jnk,MAP3K1,MAPK8,MKL1,MKL2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SRF,STAT3	
P1	 	LAMA2	-1.083	other	 	-1.980	 	0.046	-2.097	6.47E-04	CDH5,CLDN5,CSK,LAMA2,MBP,MMP9,PAG1	 	
P1	 	auranofin	 	chemical drug	 	1.471	 	-0.137	1.768	6.47E-04	CXCL8,HMOX1,HP,IL6,NQO1,ORM1,PTGS2	Ap1,BACH1,CEBPA,CEBPB,IKBKB,IL6,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SMAD3,SP1,STAT1,STAT3,TP53,TXN,auranofin	
P1	 	nelfinavir	 	chemical drug	 	1.988	bias	-0.270	2.683	6.47E-04	ADIPOQ,ATF4,DDIT3,LIPE,MMP9,PLIN1,TNFRSF10B	CTNNB1,HSD11B1,MMP9,NFKB1,NFkB (complex),NOTCH1,NR3C1,PPARA,PPARD,PPARG,RELA,SREBF1,fatty acid,nelfinavir	
P1	 	ALKBH5	0.330	enzyme	 	 	 	 	 	6.57E-04	ADGRG2,ASB1,AXL,CAV1,CHN1,CTSD,CYP11A1,DDX3X,DNM1L,FYN,GSTM5,HSPA8,LHCGR,MAST2,MBP,RARA,RPA1,RPLP0,SBF1,SLC4A2,SLC7A8,STON1,UBA1	 	
P1	 	mitomycin C	 	chemical drug	 	-0.262	bias	0.374	-1.777	6.59E-04	ATF3,BCL2L1,BTG2,CXCL8,EGR1,GADD45A,HBEGF,IRF2BP2,IRF2BPL,JUN,MCAM,NQO1,PARP2,PPP1R15A,PRKCE,SESN2,TYMP,ZMAT3	ATF2,ATM,Ap1,Creb,IFNG,JUN,Jnk,MAPK9,MYC,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TP53,TP73,mitomycin C	
P1	 	MAP3K7	0.342	kinase	 	1.337	 	0.144	0.727	6.76E-04	ACTA1,BIRC3,CD14,CFB,CH25H,CXCL2,CXCL8,GBP1,HMOX1,IL6,JUN,MAP2K3,PTGS2,SAA1,SELE,SPTBN1,TNFSF10,VHL,XAF1	ATF2,HIF1A,JUN,MAP3K7,NFKB1,NFKB2,NFKBIA,NFkB (complex),RCAN1,RELA,STAT3,TAB1,TNF,TP53	
P1	 	NRG2	0.234	growth factor	 	 	 	 	 	6.76E-04	BIN1,CCND3,CTGF,CYR61,DNAJB2,EDN1,EGR1,ERBB2,FOSB,HMOX1,IER2,IER3,IRF3,JUNB,MCL1,NR4A3,PFKFB1,PHKG1,SGSH	Akt,ERBB2,ERBB3,ERK1/2,ESR2,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),NRG2,PGR,RELA,SMAD3,SP1,STAT3,TP53,estrogen receptor	
P1	 	miR-199a-5p (and other miRNAs w/seed CCAGUGU)	 	mature microrna	 	1.880	bias	-0.487	4.022	6.82E-04	ACTA1,ACTG2,COL1A1,COL4A5,CSTB,ETS1,HIF1A,ID3,IFI27,ITGA1,ITGA3,KLF2,KLF4,MYH11,NEDD9,PADI4,TAGLN,TGFBR2,TGFBR3,WNT5B	 	
P1	 	diethylstilbestrol	 	chemical drug	 	0.350	 	0.211	-0.831	7.01E-04	ACTA1,ADH1C,ADIPOQ,ADM2,ALPL,AMHR2,AQP9,C1QA,CD14,CD55,CFB,CLSTN2,COMP,CRABP2,DCLK1,EGR1,EMP1,ESR1,FMO1,FOS,FRZB,GADD45A,GAP43,GJB2,GLRX,GSPT1,GSTM3,HBEGF,HDC,HOXA9,HRSP12,IGFBP3,IGFBP6,INHBB,KDR,KLF4,LMO4,LTBP2,MAOA,PTTG1,RPN2,RUNX1,S100A8,SOCS2,SPARC,SRC	4-hydroxytamoxifen,AR,ATF2,CREB1,Creb,EGFR,ERBB2,ESR1,ESR2,FOS,HDAC1,JUN,MYC,NFkB (complex),SMAD3,SP1,STAT3,TP53,diethylstilbestrol,estrogen receptor,testosterone	
P1	 	GDF9	-0.071	growth factor	 	-0.790	 	0.178	-1.359	7.02E-04	CTGF,CYP11A1,ID1,ID3,INHBB,KIT,LHCGR,LOX,PTGS2,PTX3,SMAD6,SMAD7,VCAN	Ap1,BMP15,BMP7,CEBPB,CREB1,ESR2,FOS,FSH,GDF9,JUN,NFKB2,NFkB (complex),PGR,SMAD1,SMAD3,SMAD4,SMAD5,SMAD7,SP1,Smad,progesterone	
P1	 	ibuprofen	 	chemical drug	 	0.606	 	-0.157	1.118	7.02E-04	CD36,EPAS1,GDF15,HIF1A,IL6,ITGAM,MMP2,MMP9,PLIN2,PTGS2,SERPINA3,TNFRSF10B,TNFRSF21	Ap1,CTNNB1,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,aspirin,ibuprofen,prostaglandin E2,sphingosine-1-phosphate	
P1	 	bezafibrate	 	chemical drug	 	0.615	bias	0.350	-1.070	7.28E-04	ACAD11,ACADM,ACADVL,ACOT4,ACSL4,ADIPOQ,ALDH1A2,ANGPTL4,APOE,CAT,CD36,CDK4,CS,CYB5A,DECR2,DNM1L,ECI1,HADHA,HSPA5,LEP,MGMT,PANK1,PDK4,PTGS2,UCP2	ATF6,Ap1,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SREBF1,bezafibrate,oleic acid,palmitic acid	
P1	 	AKIRIN2	0.463	other	 	0.514	 	0.215	0.045	7.29E-04	CCND2,DUSP1,IL6,MMP9,MYC	AKIRIN2,CTNNB1,ERK1/2,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,STAT3	
P1	 	ENO1	0.687	enzyme	 	 	 	 	 	7.29E-04	BCL2L1,ENO1,MYC,PTGS2,SELE	ENO1,ERK1/2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3	
P1	 	KDM3A	-0.160	transcription regulator	 	0.277	 	0.215	-0.199	7.29E-04	ADM,EDN1,GDF15,HMOX1,LEP	 	
P1	 	LRP2	0.001	transporter	 	0.651	 	0.072	0.492	7.29E-04	BMP4,CA3,CTSB,DAB2,NLRP3	 	
P1	 	P2RY1	0.054	g-protein coupled receptor	 	-1.581	bias	0.501	 	7.29E-04	FOS,IL6,LEP,SELE,VCAM1	CEBPB,CREB1,Ca2+,Creb,FOS,JUN,L-glutamic acid,NFKBIA,NFkB (complex),P2RY1,RELA,SP1,STAT1,STAT3,TP53,cyclic AMP,norepinephrine	
P1	 	P2RY4	0.009	g-protein coupled receptor	 	0.447	bias	0.501	 	7.29E-04	MMP9,SELE,TIMP1,TIMP4,VCAM1	EDN1,HIF1A,JUN,NFkB (complex),P2RY4,SP1,STAT3	
P1	 	PLA2G2A	1.169	enzyme	Inhibited	-2.228	bias	0.501	 	7.29E-04	CD69,CXCL8,IL6,PLA2G4A,PTGS2	ATF2,Ap1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PLA2G2A,PPARA,PPARD,PPARG,RELA,SREBF1,STAT3,TP53,arachidonic acid,fatty acid	
P1	 	PROK1	-0.155	growth factor	 	 	 	 	 	7.29E-04	CTGF,CXCL8,MCL1,PTGS2,RCAN1	ATF2,Akt,CEBPA,CEBPB,EGFR,FOS,HIF1A,JUN,MAPK1,NFKB1,NFkB (complex),PROK1,RELA,SMAD3,SP1,SRC,STAT1,STAT3,TP53	
P1	 	paraquat	 	chemical toxicant	 	0.650	bias	0.284	-0.755	7.33E-04	--,AGT,BCL2L1,CAT,CEBPD,COL1A1,CTGF,CXCL8,DIP2B,ELN,GSR,HMOX1,IL6,ITGAM,KCNMA1,KIAA1217,KLF2,LPIN2,MKL2,MMP9,PLCE1,PLTP,PTGS2,SFTPD,TIMP1,TMEM42,TXN,ZNF580	Ap1,CAT,ERK1/2,FOS,JUN,Jnk,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,paraquat	
P1	 	staurosporine	 	chemical - kinase inhibitor	 	0.708	 	-0.072	1.038	7.33E-04	ANXA5,BCL2L1,BTG2,CDK4,COL1A1,COL1A2,CSF3R,CXCL8,CYP11A1,FOS,H19,HDC,HMOX1,IFIT2,IL6,INHBB,MCL1,MME,MMP9,NEDD9,NQO1,ODC1,PLAT,PTGS2,RCAN1,SELE,SERPINA3,TGFBR3	Ap1,ERK,IL1B,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TNF,staurosporine	
P1	 	fenofibrate	 	chemical drug	 	1.793	 	0.137	0.945	7.46E-04	ACADM,ACADVL,ACAT1,ACSL4,ADIPOQ,ADIPOR2,ALDH1A2,ANGPTL4,APOB,ASNS,CASP4,CAT,CCL2,CD36,CDH2,CSF1R,CXCL8,CYP11A1,EDN1,FBP1,GADD45A,GAPDH,GBE1,GLUL,GOT1,GOT2,GPAM,HADHA,HIF1A,HMOX1,HP,IL6,JUN,KDR,MGMT,PAICS,PANK1,PDK4,PLTP,POLD1,POR,PSMA4,PTGS2,PTPRF,SLC27A1,SLCO2B1,STK36,THRA,TPP1,UCP2,VCAM1	ADIPOQ,Ap1,CEBPB,FOXO1,Growth hormone,HIF1A,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,THRB,fenofibrate,reactive oxygen species	
P1	 	BRAF	0.001	kinase	 	-1.293	 	0.234	-1.855	7.53E-04	BIRC3,BMF,CSF1R,CXCL8,EGR1,EPAS1,HIF1A,IL6,MCL1,MMP9,MYC,SERPINE2,THBS1,TPO,TSC22D1,VHL	Akt,BRAF,CEBPB,ELK1,FOS,HIF1A,JUN,MAP2K1,MAPK3,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SRF,STAT1,STAT3,TP53	
P1	 	ritonavir	 	chemical drug	 	0.371	 	-0.100	0.714	7.54E-04	ACAT2,ADIPOQ,ATP2B1,AXIN2,BCL2L1,CARS,CCND2,CD36,CD59,CXCL8,CYP2C8,DHCR7,EIF5,ELK1,IFRD1,IL6,LDLR,LEP,LIPE,ME1,MME,MMP9,MSMO1,MT1G,MYC,NAGK,PLEC,PNRC2,SELE,SPOCD1,SQLE,VCAM1	ADIPOQ,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,SP1,SRC,SREBF1,STAT3,fatty acid,ritonavir,saquinavir	
P1	 	TNFSF12	-0.128	cytokine	 	0.304	 	0.189	-0.587	7.57E-04	BCL2L1,CCL2,CCL3,CCL3L3,CCR1,CD68,CSF2RA,CXCL2,CXCL8,HES6,HEY1,HEYL,IL6,ITGAM,MMP9,NFKBIA,NOTCH1,PTX3,S100A8,S100A9,SELE,TIMP1,TNFRSF12A,VCAM1	IFNG,IL10,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNFSF12,TP53	
P1	 	phosphate	 	chemical - endogenous mammalian	 	0.433	 	0.152	-0.288	7.57E-04	ACAT1,ALPL,AXL,BMP2,COL5A1,CPNE1,CYC1,DAAM2,DECR2,EMILIN1,MAP2K3,NDUFB10,OGN,PLEC,PRPF31,RPL7L1,SDF2L1,SLC20A1,SPP1,STC1,STC2,TIMP1,XRN2,ZFP36L2	 	
P1	 	EZH2	0.460	transcription regulator	 	-1.105	 	-0.015	-1.017	7.60E-04	ADRB2,ALPL,ATF3,AXIN2,BIRC3,BMP4,C4BPB,CCND2,CCND3,CDK4,CDKN2B,CLEC3B,CRISPLD2,CSF3R,CSTF2,CXCL2,CXCL8,CYP1B1,DDT,EGR1,EPAS1,ERBB2,FRZB,FUCA1,GDF15,HOXA9,HSD11B2,IGFBP3,IL10RA,IL18RAP,IL6,ITGA1,KLF4,MAL2,MMP9,MNDA,MPZL2,MYC,MYL6B,NCOA7,NFKBIA,NKD2,PLA2G4A,PTGS2,RAP1GAP,RARRES3,RUNX1,SAA1,SAA2,SFRP2,SFRP4,SGPL1,SH3BP4,SLC1A3,SOX17	Ap1,CEBPA,CEBPB,CTNNB1,ESR1,EZH2,HDAC1,HDAC2,Hdac,Histone h3,Histone h4,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,RNA polymerase II,SIN3A,SP1,STAT1,STAT3,TP53	
P1	 	CMKLR1	0.635	g-protein coupled receptor	Inhibited	-2.236	bias	0.390	-3.108	7.63E-04	ADIPOQ,CCND2,CD55,IL6,LIPE,PLIN1	CEBPA,CEBPB,CMKLR1,FOS,Ins1,PPARA,PPARG	
P1	 	EIF4G2	-0.105	translation regulator	 	0.816	bias	0.501	 	7.63E-04	CCND2,CTSD,HIF1A,JUN,PLAT,SERPINE2	 	
P1	 	EPHB1	0.007	kinase	Inhibited	-2.429	bias	0.501	 	7.63E-04	EGR1,EGR2,FOS,JUN,JUNB,PTGS2	ELK1,EPHB1,ERK,ERK1/2,FOS,JUN,MAPK1,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	LDB1	0.043	transcription regulator	Inhibited	-2.144	bias	0.251	-2.682	7.63E-04	CDH5,EPB42,FRZB,KIT,SFRP1,SFRP2	 	
P1	 	NCK1	-0.129	kinase	 	-1.741	 	-0.056	-1.607	7.63E-04	ATF4,CD69,DDIT3,FOS,HSPA5,PPP1R15A	Ap1,EIF2AK3,ELK1,ESR1,FOS,FOXO1,FOXO3,JUN,MAPK3,MAPK9,NCK1,NFATC2,NFkB (complex),Nfat (family),RELA,STAT1,STAT3,TP53	
P1	 	PIAS3	0.090	transcription regulator	 	-0.618	bias	-0.301	0.101	7.63E-04	BCL2L1,CDKN2B,FTH1,HP,SERPINA3,TPSAB1/TPSB2	CEBPA,CEBPB,IRF8,JUN,NFKBIA,NFkB (complex),PIAS3,RELA,STAT,STAT1,STAT3,TP53	
P1	 	Trolox C	 	chemical drug	 	-0.728	 	-0.167	-0.322	7.63E-04	CCL3L3,CXCL8,HIF1A,MCL1,MMP9,UCP2	Akt,ERK1/2,GSK3B,HDAC3,HIF1A,IKK (complex),JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53,Trolox C	
P1	 	anacardic acid	 	chemical - endogenous non-mammalian	 	1.671	bias	-0.279	2.344	7.63E-04	CXCL8,DDIT3,EDN1,HSPA5,MMP9,PLAT	MYC,NFkB (complex),SP1,STAT3,TP53,TP73,anacardic acid	
P1	 	NOS2	0.174	enzyme	 	0.495	 	0.057	0.156	7.78E-04	ACTA1,ADIPOQ,ALDH3A1,ATP2A2,CCL2,CCL3L3,CD14,CD86,CSF3R,CXCL2,CXCL8,DDX3X,DLG4,EDN1,G6PD,H19,HIF1A,HMOX1,IL6,IRAK1,IRS2,KDR,KLF6,LEP,LPAR1,MMP9,MYL3,NFKBIA,PC,PERP,PTGS2,S100A8,SERPINA3,SERPINH1,SLC1A5,STXBP1,THY1,TIMP1,TNFSF10,TNK2,TYROBP	IFNG,IL10,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NOS2,RELA,SP1,STAT1,STAT3,TNF	
P1	 	E2F1	-0.037	transcription regulator	 	0.488	bias	0.345	-1.637	7.84E-04	ACTR1A,ADIPOQ,ADIPOR2,ALPL,ARHGAP4,BMP4,CAV1,CBX5,CBX7,CCND2,CCND3,CDC20,CDK4,CDKN1C,CDKN2C,CHEK2,COPS8,CRABP2,CSE1L,CTSB,CYB5A,DDAH2,DDX11,DLEU1,DUSP1,DUSP10,EGR1,EGR2,EYA2,FGF2,FHL1,FOS,GM2A,GPS2,H19,HADHA,HIST2H2AA3/HIST2H2AA4,HMGA1,HNRNPK,HOXA9,HSPA8,HSPE1,ID3,IRS2,KDR,KIT,LACTB,LEP,MAF,MCL1,MCM2,MT1G,MYC,MYCN,NCL,NFKBIA,NRP1,NUSAP1,PA2G4,PAWR,PIN1,POLA2,POLD1,PRPSAP1,PSAT1,RAN,RBBP8,RUVBL1,SELE,SLC3A2,SMARCB1,SOX7,SRPRA,THBS1,TRAP1,TRIM28,TXNL1,TXNRD1,UNG,VCAM1,YARS,ZFP36	Ap1,E2F1,EGR1,ERK1/2,ESR1,Histone h3,MYC,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TP53,TP73	
P1	 	HSD11B1	-0.418	enzyme	 	0.478	 	-0.084	0.698	7.87E-04	ACACA,ADIPOQ,AGT,ANGPTL4,CCL2,CPA3,GPAM,IL6,LEP,LIPE,PDK4,UCP2	AKT1,AR,EP300,ERK1/2,FOXO3,HSD11B1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,RELA,SMAD3,SP1,SREBF2,STAT1,STAT3,TP53,cholesterol,corticosterone	
P1	 	taurine	 	chemical - endogenous mammalian	 	0.302	 	0.017	0.244	7.87E-04	ADIPOQ,AGT,AXL,CDO1,CSAD,DLG4,GOT1,IL6,MMP2,MMP9,PTGS2,SYN1	AGT,Ap1,CAT,CREB1,ERK,ERK1/2,FOS,FSH,JUN,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,STAT1,STAT3,TP53,taurine	
P1	 	TGFA	0.190	growth factor	 	-0.774	bias	0.344	-2.312	8.06E-04	BCL2L1,BIRC3,CCL2,CTGF,CXCL2,CXCL8,DDX3X,ESR1,FOS,GJB2,IGFBP4,IL6,ITGAM,JUNB,MMP9,NR4A2,PLA2G4A,PLA2G5,PLAT,PRNP,PTGS2,PTTG1	Ap1,CEBPA,CEBPB,IL6,JUN,NFKBIA,NFkB (complex),PI3K (complex),PPARG,PTGS2,RELA,SP1,STAT1,STAT3,TGFA,TP53,prostaglandin E2	
P1	 	RETN	-0.058	other	 	-1.730	bias	0.285	-2.698	8.11E-04	ACACA,CCL2,CTGF,EDN1,FOS,HMOX1,IL6,LDLR,PLAT,PTGS2,SELE,SOCS3,SPP1,VCAM1	Ap1,D-glucose,ERK1/2,HIF1A,JUN,LDL,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,RETN,RNA polymerase II,SMAD3,STAT3	
P1	 	ATM	-0.194	kinase	Inhibited	-2.133	bias	0.379	-3.471	8.19E-04	ADIPOQ,CHEK2,CTGF,CXCL8,DUSP1,DUSP10,GADD45A,GADD45B,HMOX1,HSPE1,IL6,JUN,LEP,LPIN1,PSME2,TGM2,TNFAIP3,TNFRSF10B	ATF2,ATM,Ap1,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P1	 	miR-122-5p (miRNAs w/seed GGAGUGU)	 	mature microrna	Inhibited	-3.262	bias	-0.501	 	8.31E-04	ADAM17,ALDOA,ANK2,AP3M2,ATP1A2,BCKDK,CERS6,CS,G6PC3,GPX7,GYS1,PKM,PSME3,SLC35A4,SLC7A1,TMED3,TRIB1,TTYH3,XPO6	 	
P1	 	triamterene	 	chemical drug	 	1.576	bias	0.456	-0.392	8.31E-04	ADAMTS1,ASNS,BIRC3,CAPN6,CD14,EFEMP2,EMP3,GPNMB,GSTM3,IER3,LXN,MYC,PSMB10,RCN1,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	GATA3	-0.281	transcription regulator	 	0.106	 	-0.018	0.219	8.35E-04	ADM,ANGPTL4,AURKAIP1,BCL2L1,BHLHE41,BMF,C10orf54,CCR1,CD4,CDH2,CDKN2C,CNFN,CPA3,CRABP2,CSF1R,CYP11A1,EBF1,ELOVL3,ELOVL6,ESR1,ETS1,EVPL,FOS,FSCN1,GLUL,IL6,KIT,KLF4,LOC102724788/PRODH,LOX,MAF,MYC,MYO10,NOTCH1,NR5A2,RCAN1,RET,RGCC,S100A8,S100A9,SPI1,TJP1,TJP2,ZFPM1	Akt,CBFB,CEBPA,GATA3,HDAC1,HIF1A,IFNG,IL10,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RUNX1,SMAD1,SMAD3,SMAD4,SP1,SPI1,STAT1,STAT3,TP53	
P1	 	AREG	0.060	growth factor	 	-0.306	bias	0.432	-1.709	8.61E-04	BCL2L1,CXCR4,EGR1,ELK1,FOS,IL6,JUN,MMP9,PTGS2,PTX3,RUNX1	AREG,ATF2,Akt,EGFR,ELK1,ERK1/2,FOS,HIF1A,JUN,MAPK3,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	CHADL	0.050	other	 	-1.508	 	-0.086	-1.221	8.61E-04	CSPG4,FAM107A,GFRA2,IGFBP3,IL6,KLF2,MN1,NTRK3,PTX3,SOX9,VCAM1	 	
P1	 	LRP1	0.055	transmembrane receptor	 	-0.180	 	-0.121	0.214	8.61E-04	C1R,CCL3L3,CDH2,COL3A1,CTSD,DDIT3,MMP2,MMP9,PLIN2,PTGS2,SLC2A3	Ap1,CEBPB,CTNNB1,HIF1A,JUN,LRP1,MAP2K1,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,PI3K (complex),RAC1,RELA,SMAD3,SP1,STAT3	
P1	 	MEL S3	 	chemical - kinase inhibitor	 	-0.905	 	-0.190	-0.274	8.61E-04	ATP5D,C1QBP,COPS8,EGR1,ENO1,ERP29,GLOD4,HSPA1A/HSPA1B,PCK2,STIP1,TUBB	 	
P1	 	CDK5	0.447	kinase	 	0.605	 	0.209	-0.007	9.10E-04	CD14,GLB1,IGFBP3,JUN,KCNMA1,MBP,PPP1R1B,RALA,S100P,TNFAIP3	Ap1,CDK5,ESR1,FOS,Histone h3,JUN,NFkB (complex),RELA,RNA polymerase II,SP1	
P1	 	HAND1	-0.063	transcription regulator	 	1.929	bias	-0.274	2.790	9.10E-04	ACACA,ADSSL1,ANGPT1,EDN1,EFNB2,HEY1,KDR,LIPE,NOTCH1,NRP1	 	
P1	 	Smad	 	complex	 	-1.007	bias	0.406	-2.179	9.10E-04	ANGPTL4,CDKN2B,COL1A1,COL1A2,CTGF,ID1,ID3,MCL1,MYC,SMAD7	ATF2,EGFR,HIF1A,MYOCD,NFkB (complex),NOTCH1,RUNX2,SMAD3,SP1,STAT3,Smad,VHL	
P1	 	dibutyl phthalate	 	chemical toxicant	 	-0.756	 	0.109	-1.094	9.10E-04	CYP11A1,FOS,FST,INHBB,JUN,JUNB,MYC,ORM1,POR,SPP1	AHR,AR,CEBPA,CEBPB,Creb,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD4,SP1,STAT1,STAT3,TP53,cyclic AMP,dibutyl phthalate,testosterone	
P1	 	Collagen type IV	 	complex	 	-0.378	 	0.111	-0.673	9.11E-04	CCL2,DPYD,MMP2,MMP9,MYC,PLAUR,PTGS2,TAGLN,THBS1	ATF2,CTNNB1,Collagen type IV,EGFR,FOXO1,HIF1A,ITGB1,JUN,NFKB1,NFkB (complex),PTEN,PTK2,RELA,SMAD3,SP1,SRC,STAT1,STAT3,STAT5a/b	
P1	 	PD 153035	 	chemical drug	 	1.188	 	-0.024	1.259	9.11E-04	BCL2L1,CCL2,COL1A2,CXCL8,DDIT3,FOS,HSPA5,MCL1,PTGS2	ATF2,CEBPA,CEBPB,EGFR,JUN,MAP2K1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD 153035,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	SIN3B	0.726	transcription regulator	 	 	 	 	 	9.11E-04	CCNG2,CDK4,COL1A2,DDIT3,GADD45B,KLF6,MYC,NCL,SRD5A1	HIF1A,JUN,MAX,MYC,SIN3B,SP1,TP53	
P1	 	tosylphenylalanyl chloromethyl ketone	 	chemical - protease inhibitor	 	1.891	bias	-0.406	3.087	9.11E-04	CCL2,CXCL2,CXCL8,IL6,MMP2,MYC,PTGS2,SMAD7,VCAM1	Akt,HIF1A,IL6,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TP53,tosylphenylalanyl chloromethyl ketone	
P1	 	RXRA	0.062	ligand-dependent nuclear receptor	 	0.856	 	0.215	-0.242	9.11E-04	ABCC3,ABCG1,ACACA,ACADM,ACSL3,ADH1C,AHCY,ALDH1A1,ALDH1A2,APOE,ARG2,ASNS,CAT,CCND3,CD36,CDO1,CEBPD,CIDEA,CLMN,CLOCK,COL1A1,CRABP2,CTSH,EPHX1,FOS,HADHA,HIF1A,HMOX1,IER3,IL6,MBP,MGP,MID1IP1,MYCN,NEDD9,NME1,NR1D1,NR5A2,PC,PCK2,PLA2G2A,PLIN1,PLTP,PTGDS,RARA,RET,SLC27A1,SORBS1,SPP1,THBD,TNFRSF10B,TPP1,TXN	Ap1,CEBPA,EP300,FOXO1,JUN,L-triiodothyronine,NCOR1,NCOR2,NFkB (complex),NR3C1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,THRB,tretinoin	
P1	 	17-alpha-ethinylestradiol	 	chemical drug	 	-0.042	 	0.158	-0.765	9.15E-04	AARS,ABCC3,APOB,APOE,AQP9,ASNS,ATF4,C1QB,C1QC,CCL3L3,CCR1,CD68,CSF1R,EIF2S2,FOS,INHBB,JUN,LDLR,LPIN1,MARCO,MMP9,NME1,ODC1,PERP,PTGDS,SERPINH1,SGK1,SLC11A1,SLC4A2,SNAPC2,SPSB2,TFF3,VCAM1	17-alpha-ethinylestradiol,IFNG,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,SREBF2,STAT1,STAT3,TNF,cholesterol,lipopolysaccharide	
P1	 	EIF2AK2	0.143	kinase	Inhibited	-2.092	bias	0.436	-4.093	9.32E-04	ATF3,ATF4,CEBPD,CXCL8,DDIT3,EGR1,ERAP2,FOS,IFI27,IL6,IRS2,ISG20,KCTD13,MT1M,MYC,NEDD9,NFKBIA,NNMT,PPP1R15A,PSMB10,SELE,SOCS3,TNFAIP3	Ap1,CHUK,EIF2AK2,IKBKB,IRF8,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53	
P1	 	MET	-0.395	kinase	 	-0.768	bias	0.360	-2.453	9.32E-04	BMF,CCL3L3,CCND2,DAB2,EDN1,FOS,HBEGF,HDC,HMOX1,IL6,JUN,KLF4,MMP2,MYC,NFKBIZ,NOX4,NREP,PTGS2,RILPL1,RUNX1,SOCS3,SPP1,TSC22D1	Akt,Ap1,ERK1/2,ESR1,HIF1A,JUN,MET,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT3,TP53	
P1	 	MYB	0.264	transcription regulator	 	0.887	bias	0.382	-0.456	9.32E-04	ATP2B1,BCL2L1,BIRC3,CBX4,CD4,CDKN2B,COL1A2,CXCL12,CXCR4,ELANE,GSTM1,HSPA5,HSPA8,IGFBP3,JUN,KDR,KIT,KLF4,MTSS1,MYC,PTGS2,SLC1A5,SPP1	Akt,Ap1,ESR1,HIF1A,Histone h3,JUN,Jnk,MAX,MYB,MYC,NFKB1,NFKB2,NFkB (complex),PRKCD,RELA,RNA polymerase II,SP1,STAT3,TP53	
P1	 	H2AFY	0.342	other	 	0.577	bias	-0.339	1.751	9.37E-04	ALDH1A3,CCND2,CD36,CDKN1C,CDKN2B,CDKN2C,EGR1,ERBB2,ETS1,GADD45A,ID1,SPARC,THRSP	Ap1,ESR1,H2AFY,Histone h3,NFkB (complex),RELA,RNA polymerase II,SCD,SP1,STAT1	
P1	 	ethylene glycol tetraacetic acid	 	chemical reagent	 	1.630	bias	-0.279	2.615	9.37E-04	ATP2A2,BIRC3,CD86,CXCL8,DDIT3,EGR1,FOS,HSPA5,IL6,ITGAM,KCNJ2,RCAN1,THRSP	Ap1,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,ethylene glycol tetraacetic acid	
P1	 	CCL11	0.028	cytokine	 	-1.250	bias	0.462	-3.036	9.53E-04	BCL2L1,BMP6,CCL18,CCL2,CCL3L3,CCL8,CXCL12,CXCL2,CXCL8,HCAR3,IL6,ITGA1,ITGAM,LEP,ORMDL3,VEGFC	Ap1,CCL11,ERK1/2,FOS,HIF1A,IL13,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,STAT6,reactive oxygen species	
P1	 	PTPRJ	0.107	phosphatase	 	-1.291	bias	0.481	-3.155	9.53E-04	CCL3L3,CD69,CEBPD,CXCL2,EDN1,FOS,HBEGF,HDC,IL6,MARCO,NFKBIZ,PLAT,PTGS2,RILPL1,TPO,TSC22D1	Ap1,CTNNB1,ELK1,ERK1/2,FOS,HRAS,JUN,MAPK3,MET,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,PTPRJ,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	carbonyl cyanide m-chlorophenyl hydrazone	 	chemical toxicant	 	-1.432	bias	0.462	-3.270	9.53E-04	AADAC,AGT,ATF4,BMP6,CXCL8,DDIT4,DUSP5,GDF15,GNG11,NFKBIZ,PHLDA1,PPRC1,PTGS2,SPX,ST6GALNAC3,TM6SF1	AGT,AKT1,Ap1,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PLA2G2A,PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53,carbonyl cyanide m-chlorophenyl hydrazone	
P1	 	miR-145-5p (and other miRNAs w/seed UCCAGUU)	 	mature microrna	 	-0.494	bias	-0.501	 	9.53E-04	AHNAK,CDK4,CES1,DTD1,EIF4EBP2,F11R,FSCN1,KLF4,LAMP2,MAPK7,MYC,MYH11,RTKN,SWAP70,TAGLN,UNG	NFkB (complex),SMAD3,SMAD4,SP1,STAT3,TGFB1,miR-145-5p (and other miRNAs w/seed UCCAGUU)	
P1	 	IL6R	-0.136	transmembrane receptor	 	-0.628	bias	0.383	-2.254	1.01E-03	ABCC1,ABCC3,CCL2,CCL3,CD36,COL1A1,COL1A2,CXCL2,CXCL8,HP,IL6,MCL1,MMP2,MMP9,PTGS2,SAA1,SERPINA3,SOCS3,TIMP1,VCAM1	Ap1,CEBPA,CEBPB,ERK1/2,IL6,IL6R,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	F3	-0.404	transmembrane receptor	 	-1.133	bias	0.501	 	1.01E-03	ANGPT1,CARD9,CCL2,CTGF,CXCL8,CYR61,EGR1,FOS,IL6,ITGAM,MDK,MMP2,MMP9,PODXL2,SPRY1,TGFBR2,TGM2,UBASH3B	Akt,Ap1,F10,F2R,F2RL1,F3,F7,HIF1A,JUN,NFkB (complex),RELA,SP1,STAT3,TP53	
P1	 	heparin	 	chemical - endogenous mammalian	 	-0.409	 	0.134	-0.920	1.02E-03	ACADM,ACADVL,APOB,APOE,CD209,CD86,CNN1,COL1A1,CS,CYP11A1,FOS,IGFBP3,LHCGR,MMP2,MMP9,NDUFA9,PLAT,PROCR,THBD	APOE,Ap1,CTNNB1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TNF,Tgf beta,heparin	
P1	 	PRKAA2	-0.000	kinase	 	-0.975	 	-0.218	0.117	1.05E-03	ACOT7,ACTA1,CD302,CIDEA,CXCL12,DDIT3,EGR1,ERN1,GALM,HIF1A,HIGD1A,HSPA5,IGFBP4,IL6,LEP,LMO4,MMP9,MYLK,NCF2,NFKBIA,NOX4,PARP3,PCOLCE,SERPINI1,SORL1,TGM2,TTYH1	AMPK,Akt,FOXO1,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,PRKAA1,PRKAA2,RELA,SREBF1,STAT1,STAT3,TP53,fatty acid,palmitic acid	
P1	 	ABCB6	1.460	transporter	Inhibited	-2.168	 	0.035	-2.298	1.05E-03	ALAD,ALAS2,ATPIF1,CAT,CYP2R1,CYP4B1,FECH,HAGH,HK1,HMBS,PPOX,SLC25A39,TXNRD2,UROS	 	
P1	 	SELP	-0.042	transmembrane receptor	Inhibited	-2.891	bias	0.354	-4.112	1.07E-03	CCL2,CCL3,CCL3L3,CXCL2,CXCL8,CXCR4,CYP1B1,HCAR3,IL6,PLAUR,PRKCD,THBD	CEBPB,IFNG,IL17A,IL4,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SELP,SP1,STAT1,STAT3,STAT6,lipopolysaccharide	
P1	 	dextran sulfate	 	chemical drug	 	-1.699	bias	0.255	-2.601	1.07E-03	ADAMTS1,AGT,CCL3L3,CD14,CD209,CD36,CD86,CDC20,CDCA5,CHTF18,COL18A1,CTGF,CXCL2,CXCL8,EFEMP2,EFNB2,GADD45GIP1,GSTM5,HMOX1,ID3,IDO1,IL6,LY96,MMP2,MMP9,MNS1,MYC,MYLK,NQO1,NRP1,NUSAP1,POLD1,PTGS2,RBBP9,S100A8,S100A9,S1PR1,SOCS3,TGFBR2,TGFBR3,TGM2,THBS1,THBS4,TJP1,VCAM1,VEGFC,VEGFD	CEBPB,IL17A,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,dextran sulfate	
P1	 	SATB1	-0.322	transcription regulator	Activated	2.089	 	-0.096	2.659	1.09E-03	ACTN1,ARF5,CD69,CD86,CORO6,CSF3R,CTSD,EPAS1,ETS1,FAM129A,FAM65B,FOSB,GADD45B,GDF15,GLRX,HSPA8,ID3,IL10RA,IL18RAP,KLF2,LPIN2,LRRN3,MT1A,NR4A2,PTGS2,RASGRP2,RGS1,RPLP0,RPLP1,RUNX1,S1PR1,SGK1,SPI1,TMEM2,TSPAN17,WARS,XAF1	CTNNB1,HDAC1,JUN,NFkB (complex),SATB1,STAT3,TCF	
P1	 	MECP2	0.058	transcription regulator	 	-0.496	 	-0.076	-0.290	1.11E-03	APOE,BCAT2,CAPG,CDKN2B,CYB5A,EGR1,ENPP4,ESR1,HSPA5,IGFBP3,IRAK1,IVD,JUNB,LMNA,MBP,MGMT,MT1A,MT1G,MYC,PTGS2,RELN,SGK1,SLC2A3,SYN1,TFPI2,UQCRC1	Ap1,CEBPB,ELK1,FOS,HDAC1,HIF1A,IGF1,IRF8,JUN,MAPK1,MAPK3,MECP2,MYC,NFkB (complex),RELA,SMAD3,SP1,SPI1,STAT1,STAT3,TP53,doxorubicin	
P1	 	LTBR	0.796	transmembrane receptor	 	0.128	bias	0.301	-0.989	1.14E-03	BCL2L1,CD86,CNN1,COCH,CXCL12,DSG2,ENPP2,FAAH,GPM6B,IL6,LYZ,NFKBIA,PCDH17,PRNP,VCAM1	FOS,IFNG,JUN,LTBR,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53	
P1	 	CSF3R	-0.975	transmembrane receptor	 	 	 	 	 	1.14E-03	CD14,CSF3R,CXCL12,FOS,ITGAM,LYZ,SELE	AR,Ap1,CEBPA,CEBPB,CSF3R,EGR1,JUN,Jnk,NFkB (complex),RELA,SIRT1,SP1,STAT1,STAT3,TP53	
P1	 	NFkB (family)	 	group	 	-0.447	bias	0.401	-1.344	1.14E-03	BCL2L1,BSG,CXCL8,MMP9,PTGS2,TNFAIP3,TNFSF10	FOS,NFKB1,NFKB2,NFkB (complex),NFkB (family),RELA	
P1	 	TFAP2B	0.032	transcription regulator	 	0.000	 	0.228	-0.558	1.14E-03	EDN1,EPAS1,ERBB2,KIT,MMP2,MT2A,SLC19A1	FOXO1,Growth hormone,HIF1A,Insulin,PPARA,PPARG,TFAP2B	
P1	 	gallic acid	 	chemical - endogenous non-mammalian	 	-0.436	bias	-0.424	0.675	1.14E-03	ADAM17,CXCL8,IL6,MMP2,MMP9,PLAT,VCAM1	Akt,Ap1,CAT,CREB1,ESR2,FOS,HDAC3,HIF1A,IKK (complex),JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,STAT3,TP53,gallic acid	
P1	 	xanthine	 	chemical - endogenous mammalian	 	-0.455	bias	0.358	-1.374	1.14E-03	CD69,CXCR4,DUSP1,DUSP10,ID3,MMP2,PLAUR	ATF2,Ap1,CTNNB1,EGFR,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SRC,STAT3,XDH,xanthine	
P1	 	MKL2	-0.527	transcription regulator	 	-1.732	bias	-0.315	-0.641	1.15E-03	ACTA1,BCL2L1,CNN2,CPA3,CTSG,CXCR4,CYBA,DHCR24,DNAJB4,ELANE,ETV6,EYA2,FLNA,G0S2,GSTM5,OSCP1,RUNX1,S100A8,S100A9,SLC20A1,TAGLN,ZFPM1	 	
P1	 	ANXA2	-0.319	other	Inhibited	-3.132	 	-0.017	-3.078	1.20E-03	ANG,GADD45A,IGFBP3,IL6,JUN,MMP2,MYC,PTGS2,SESN2,TNFRSF10B,ZMAT3	ANXA2,Akt,Ap1,CEBPA,CEBPB,ERK1/2,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	IL17RA	-0.312	transmembrane receptor	 	-1.062	bias	0.432	-2.479	1.20E-03	CCR1,CSF3R,CXCL12,CXCL2,CXCL8,IL6,MMP9,S100A8,S100A9,SELE,TIMP1	Ap1,CEBPB,FOS,IL13,IL17A,IL17RA,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,STAT6	
P1	 	bardoxolone methyl	 	chemical drug	 	1.734	bias	-0.347	2.865	1.20E-03	BCL2L1,BIRC3,CCL3L3,GCLM,HMOX1,IL6,MMP9,MYC,PTGS2,THRSP,TNFRSF10B	AKT1,Ap1,GSK3B,HDAC3,IKK (complex),JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TP53,bardoxolone methyl	
P1	 	proteasome inhibitor PSI	 	chemical - protease inhibitor	Activated	2.225	 	0.167	1.691	1.20E-03	BMP2,CCL3,CD55,CXCL2,DDIT3,HMOX1,HSPA5,IL6,PRKCE,SQSTM1,TJP1	26s Proteasome,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PTAFR,RELA,SP1,STAT1,STAT3,TNF,proteasome inhibitor PSI	
P1	 	KLF5	0.045	transcription regulator	 	-0.481	bias	0.285	-1.596	1.20E-03	ACADM,BRE,CXCR4,DUSP1,EPAS1,HIF1A,MMP9,MYC,NOTCH1,PREB,RUNX1,S100A9,SLC35F6,SORCS2,TAGLN,UCP2	ARNT,CTNNB1,DUSP1,ERK,HIF1A,JUN,KLF5,MMP9,MYC,NFKB1,NFkB (complex),NOTCH1,PPARG,RELA,SMAD3,STAT3,TP53,VHL,ZFP36	
P1	 	MAP2K6	-0.078	kinase	Inhibited	-2.803	bias	0.339	-3.752	1.21E-03	ACP5,ACTA1,ATP2A2,CCL2,CCL8,CD86,CXCL8,IFIT2,IL6,IRS2,JUN,LDLR,MMP2,MMP9,MYH1,MYH11,PLA2G2A,PTGS2,SLC1A3,TNFSF10	Ap1,ERK,ERK1/2,ESR1,IL6,JUN,MAP2K6,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	PLG	0.040	peptidase	 	-0.887	bias	0.487	-2.964	1.21E-03	ADIPOQ,CAV1,CCL2,CNN2,COL1A1,COLEC12,CYR61,DOCK1,EDN1,FYN,GULP1,IL6,MCOLN3,MIF,MMP9,PLA2G5,PRKCE,PTGS2,RAB5A,RALA	Ap1,ERK1/2,ETS1,F2R,JUN,NFKBIA,NFkB (complex),P38 MAPK,PLG,RELA,SMAD3,SMAD4,SP1,STAT3,Tgf beta,VEGFA	
P1	 	TNFRSF1B	-0.302	transmembrane receptor	 	0.482	bias	0.285	-0.678	1.21E-03	ABCC3,BCL2L1,CD69,CXCL12,CXCL8,IL6,JUN,LBP,LEP,MBP,MMP2,MMP9,NR5A2,P2RX7,SAA1,SOCS3,SRC,TIMP1,TNFAIP3,TYMP	Ap1,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TNFRSF1B,Tnf (family)	
P1	 	cadmium	 	chemical toxicant	 	1.173	 	0.198	0.327	1.21E-03	BCL2L1,CUBN,CYB5A,CYP26B1,EPHX1,HIF1A,HMOX1,HNRNPK,HSPA5,IGF2R,JUN,LOX,MGP,MYC,PECR,PTGS2,SGK1,SLC22A12,SLC39A8,TIMP1	Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,TP53,cadmium,reactive oxygen species	
P1	 	NFATC3	0.192	transcription regulator	 	-0.072	bias	0.334	-1.096	1.23E-03	ABCA3,ATF3,BMP2,CD69,COL1A1,DDIT4,EDN1,EGR2,EGR3,FOS,GAP43,IL6,JUN,NUPR1,PTGS2,SFTPD,STIM1	Ap1,FOS,JUN,NFATC3,NFkB (complex),RELA,SP1	
P1	 	SCD	-0.075	enzyme	 	-0.183	 	-0.130	0.311	1.23E-03	ACACA,ACADVL,ANGPTL4,ATF3,CCL3L3,CD36,CXCL8,DDIT3,GADD45A,GPAM,HSPA5,IL6,LEP,LIPE,SLC27A1,SPTLC2,UCP2	ATF6,CREB1,FOS,INSR,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PDX1,PPARA,PPARD,PPARG,RELA,SCD,SREBF1,STAT3,STAT5a/b,TNF,fatty acid,oleic acid	
P1	 	GLI1	-0.107	transcription regulator	 	0.395	bias	0.413	-2.124	1.23E-03	ACADVL,BCL2L1,CAV1,CCND2,CD24,CDC34,COL1A1,DRG2,EGR3,EPB41L4B,FHL1,GPC3,HEY2,IGFBP6,IL6,IMPA2,KLF4,LMNA,MAN1C1,MMP2,MMP9,MYCN,NQO2,NREP,PCOLCE2,PDZRN3,PHLDA2,PLOD1,POMC,PRKCE,PVR,RAB34,RHOB,S100A9,SFRP1,SH3GLB1,SOX9,SPP1,TMEM100,TMEM79,TSC22D1,TUFM	Ap1,CTNNB1,ESR1,ETS1,GLI1,HDAC1,Histone h3,JUN,MYC,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TCF,TP53,TP73,VEGFA	
P1	 	ITGB3	-0.193	transmembrane receptor	 	1.213	 	0.180	0.543	1.23E-03	ACLY,BCL2L1,CD36,COL1A1,COL1A2,FOS,KDR,LDLR,LIMS1,MMP2,MMP9,NDUFV1,PLAUR,PTGS2,RUNX1,SMAD7,SPARC,TGFBR2,TIMP1	Ap1,COL4A3,ITGB3,JUN,NFKB1,NFKBIA,NFkB (complex),PTK2,RELA,SMAD3,SMAD4,SP1,SPP1,SRC,STAT1,STAT3,Tgf beta	
P1	 	Il3	 	cytokine	 	0.600	 	0.167	-0.017	1.23E-03	ATF5,BCL2L1,CCND2,CCND3,CD14,CD68,CSF1R,CSF3R,EGR1,ELANE,FOS,HRAS,IL6,ITGAM,LYZ,MCL1,MYC,PRKCE,SPP1	CSF2RB,IRF8,Il3,JUN,KIT,Mek,NFKBIA,NFkB (complex),PTPN11,SPI1,SRF,STAT,STAT1,STAT3,STAT4,STAT5A,STAT5a/b,TP53	
P1	 	SPDEF	0.008	transcription regulator	 	-1.872	bias	-0.325	-0.574	1.23E-03	BIRC3,CDH2,COL16A1,COL1A1,COL4A5,COL5A1,COL5A2,COL6A1,COL6A2,COL6A3,CTGF,CXCL8,DKK3,HIF1A,ITGA3,PLAUR,PTPRF,SOX17,SQSTM1	CTNNB1,HDAC1,JUN,NFkB (complex),SPDEF,STAT3,TCF	
P1	 	POMC	0.874	other	 	-0.665	 	0.186	-1.520	1.24E-03	ACSL4,APOB,CXCR4,CYP11A1,CYP1B1,DUSP1,FGF2,FOS,GAPDH,GSTM5,H19,HMOX1,HSD11B2,IL6,JUN,JUNB,LDLR,LEP,NR4A2,NR4A3,PCSK5,POMC,SELE,VCAM1	AR,CREB1,Creb,FOXO3,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,P38 MAPK,POMC,Pka,RELA,SP1,STAT1,STAT3,corticosterone	
P1	 	cocaine	 	chemical drug	 	-1.686	bias	0.321	-3.576	1.26E-03	ADCY1,ASGR1,CCL2,CLOCK,CXCL2,CXCL8,DLG4,DUSP1,DUSP14,DUSP5,EFNB2,EGR1,EGR2,FGF2,FOS,FOSB,GADD45A,GADD45B,HSPA4,IL6,IRS2,JUN,JUNB,MCL1,MKNK2,MNS1,NPTX2,NR4A3,POMC,PPP1R1B,PPRC1,SERTAD1,SIAH2,SIGMAR1,THBS1,TIPARP,TUBB,UBASH3B	ATF4,CEBPB,CREB1,CREBBP,CREM,Creb,E2F1,EGR1,ELK1,ERK,ERK1/2,FOS,FOXO1,JUN,MAPK3,NFKBIA,NFkB (complex),PPARG,RELA,SIRT1,SMAD3,STAT3,cocaine	
P1	 	CHI3L1	0.186	enzyme	 	 	 	 	 	1.30E-03	COL16A1,COL6A1,COL6A2,CXCL8,EMP1,MMP9,NNMT,PEG10,TGFBR2,TMEM158	Ap1,CHI3L1,FOS,IL13,NFkB (complex),STAT3,STAT6	
P1	 	NPR1	0.088	enzyme	 	-1.687	bias	-0.341	-0.676	1.30E-03	ACTA1,AGT,COL1A1,COL3A1,GBA,GUCY1A3,MMP2,MMP9,RCAN1,SLC9A1	ERK1/2,GATA4,HIF1A,NFKB1,NFKBIA,NFkB (complex),NPR1,RELA,RXRA,SMAD3,STAT3	
P1	 	bryostatin 1	 	chemical drug	 	0.444	bias	0.334	-0.535	1.30E-03	BIRC3,CCL3,CD209,CD86,CXCL8,CXCR4,IL6,MYC,ODC1,PRKCD	ERK1/2,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,RELA,SMAD3,STAT3,TNF,bryostatin 1	
P1	 	FGF8	-0.100	growth factor	 	0.894	 	0.147	0.197	1.30E-03	BMP2,BMP4,CCDC50,CCL2,CDK20,CMTM3,COL18A1,CRIP1,DDAH2,ETV5,GPR4,MDK,PCOLCE2,RASD1,RGS12,SHC1,SLC22A17,SPARC,SPP1,SPRY2,THBS1,TM7SF2,TRIP6	ELK1,FGF8,FOS,JUN,MAPK3,NFkB (complex),STAT3	
P1	 	ADRB1	-0.195	g-protein coupled receptor	 	0.246	 	0.167	-0.124	1.32E-03	COL3A1,DDIT3,HSPA5,IRAK1,LEP,NGF,SLC9A1,THBS1	ADRB1,ATF2,Ap1,CEBPB,CREB1,Creb,EGFR,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,Pka,RELA,SMAD3,SP1,STAT1,STAT3,cyclic AMP	
P1	 	MPZ	0.163	other	 	 	 	 	 	1.32E-03	ATF4,DDIT3,HMGCS1,HSPA5,MVD,PPP1R15A,SDF2L1,SQLE	 	
P1	 	Pdgf Ab	 	complex	 	-0.674	bias	0.383	-1.734	1.32E-03	ANGPT1,COL8A1,FOS,HBEGF,HIF1A,HMOX1,IL6,VEGFC	ARNT,Akt,Ap1,ETS1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,Pdgf Ab,RELA,SP1,STAT3,TP53,VEGFA,VHL	
P1	 	ABCA1	-0.245	transporter	 	0.476	 	-0.100	0.790	1.36E-03	ABCA5,ABCA8,ABCG1,ADIPOQ,APOB,APOE,CCL3L3,CYP51A1,DGAT2,HSPA5,IL6,LDLR,LEP,PTGS2	ABCA1,APOE,CREB1,CTNNB1,Creb,ERK1/2,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pka,RELA,SMAD3,SP1,SREBF2,STAT1,STAT3,cholesterol	
P1	 	ALB	0.214	transporter	 	-0.395	bias	0.290	-1.380	1.36E-03	AGT,CCL2,CDKN1C,COL1A1,CXCL8,CYBA,DDIT3,EDN1,EDNRA,ERN1,HSPA5,IL6,PTGS2,SQSTM1	AGT,ALB,Ap1,CREB1,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,Pkc(s),RELA,SMAD3,STAT3,palmitic acid	
P1	 	GPS2	0.647	transcription regulator	 	0.535	bias	-0.478	2.321	1.36E-03	ADIPOR2,BIN1,CXCL8,DHRS3,IDH1,LHPP,MCTP1,NFKBIA,RGL1,RHOB,RNF144B,SGK1,SNX1,VCAM1	FOXO1,GPS2,NFkB (complex),PPARA,PPARG,PPARGC1A,RXRA	
P1	 	niacinamide	 	chemical - endogenous mammalian	 	1.029	 	0.037	0.903	1.36E-03	CCL2,CD14,G6PD,GAPDH,H2AFZ,IL6,ITGAM,JUNB,MCL1,MMP9,MYC,NNMT,PTGS2,SHC1	Ap1,CEBPA,CEBPB,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,niacinamide,prostaglandin E2	
P1	 	pitavastatin	 	chemical drug	 	0.066	bias	0.410	-1.141	1.36E-03	ACADM,CAT,CD36,CYP51A1,HMGCS1,LSS,MVD,PTGS2,SQLE	Ap1,FOXO1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RXRA,SREBF1,pitavastatin	
P1	 	prostaglandin A1	 	chemical - endogenous non-mammalian	 	-0.142	 	0.167	-0.610	1.36E-03	BCL2L1,CD14,CXCL8,HMOX1,HSPA1A/HSPA1B,HSPA4,IL6,NFKBIA,PTGS2	Ap1,HDAC3,IKBKB,IKK (complex),JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,doxorubicin,prostaglandin A1	
P1	 	LIF	0.005	cytokine	 	-1.940	 	0.100	-2.524	1.37E-03	ACACA,AHNAK,BCL2L1,BMP2,C16orf89,CCL3L3,CDH5,CEBPD,COCH,CSF1R,CXCL2,CXCL8,CYP11A1,EGR1,FBP1,FOS,HBEGF,HEY1,HIF1A,HLA-G,IL34,IL6,JUN,JUNB,KDR,LARGE1,LBP,LEP,LIMS1,MYC,PELI1,POMC,PRPH,PTGS2,RET,RHOU,SERPINA3,SOCS2,SOCS3,SPP1,TIMP1,ZFP42	CEBPA,CEBPB,ERK1/2,IRF8,JUN,LIF,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,STAT,STAT1,STAT3,TP53	
P1	 	caffeic acid phenethyl ester	 	chemical drug	 	-0.569	bias	-0.375	1.260	1.37E-03	ABL1,BCL2L1,CTSB,CXCL8,DDIT3,EGR1,ELK1,ERCC1,ESR1,FCGRT,FTH1,GSR,HMOX1,IGFBP6,IL6,KLF6,LEP,MMP2,NFKBIA,NQO1,PTGFR,PTGS2,RARA,RHOB,VCAM1	Ap1,FOS,JUN,Jnk,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,caffeic acid phenethyl ester,nitric oxide	
P1	 	ETS1	-0.581	transcription regulator	 	-0.092	bias	0.351	-1.537	1.40E-03	AXIN1,BCL2L1,BMP4,CAV1,CCL2,CD14,CDH5,COL1A2,CSF1R,CTGF,DNAJA3,EGR1,ERBB2,ETS1,ETS2,GABRE,HCST,HMOX1,HS2ST1,HSPA1A/HSPA1B,HSPA8,HSPE1,ITGA10,JUNB,KRT8,MCL1,MMP2,MMP9,MYC,NCLN,NQO1,PEG10,PERP,PHLDA2,PLAA,PVR,RUNX1,SPI1,SPP1,SRD5A1,SRGN,TGFBR2,THY1,WAS	Ap1,CREB1,CREBBP,CSF2,EP300,ESR1,ETS1,HIF1A,Histone h3,MYC,NFkB (complex),RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53,TP73	
P1	 	histamine	 	chemical - endogenous mammalian	 	-0.732	bias	0.251	-1.729	1.41E-03	BMP2,CCL2,CCL3,CD86,CXCL8,CXCR4,FOS,GDF15,HBEGF,HIF1A,IL6,JUN,LDLR,LEP,NGF,POMC,PTGIS,PTGS2,SELE,STIM1,TJP1	Ap1,CEBPB,IL1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF,cyclic AMP,histamine	
P1	 	IFNA2	0.025	cytokine	 	-1.507	bias	0.425	-3.867	1.42E-03	ATF5,C1R,CAV1,CCL2,CCL8,CD86,CDKN2B,CYB5A,DIABLO,DNAJB2,EPB41L3,FAM134A,FGF2,GBP1,GOT1,HBEGF,HIF1A,HMGCS1,IFI27,IFI27L2,IFIT2,IFNAR2,IL6,ISG20,LY6E,LYN,MMP9,MT1F,MT1G,MT1L,MT1M,MT1X,MT2A,MYC,NPTX2,PLAT,PTTG1,RARRES3,SLC15A3,SOCS2,SOCS3,SP110,TNFRSF10B,TNFSF10,VEGFC,XAF1	CEBPA,CEBPB,ERK1/2,FOS,IFNA2,IRF8,JUN,MAPK1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	IFNB1	0.004	cytokine	 	-1.677	 	0.236	-2.969	1.43E-03	AGL,ANXA5,AXL,BCL2L1,CAPN2,CCL2,CCL3,CD14,CD86,CDH2,CH25H,COL12A1,CTSK,CXCL2,CXCL8,DEFB1,DKK3,FGF2,FOS,GBP4,GPC4,GZMH,HMGCS1,IDO1,IFI27,IFIT2,IL6,IRF3,ISG20,MMP2,MMP9,MYC,NDUFA13,NFIX,NID2,NNMT,NOTCH1,OGN,PDK4,PHLDB2,PKP2,PTGS2,RARRES3,RNASE4,SPRY1,SPRY2,SQLE,THBS1,TIMP1,TNFRSF4,TNFSF10,UBE2E2,UCHL1,XAF1	Ap1,CEBPA,CEBPB,IFNB1,IFNG,IL10,IL1A,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53	
P1	 	PTGS1	0.258	enzyme	 	1.262	 	0.060	1.088	1.43E-03	ANGPT1,ATF3,FGF2,GZMH,IL6,JCHAIN,MMP2,MMP9,PLA2G4A,PTGER4,PTGS2,STC1	Ap1,CEBPB,CTNNB1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,NS-398,PPARG,PTGS1,PTGS2,RELA,SP1,STAT3,TP53,aspirin,indomethacin,prostaglandin E2	
P1	 	fluvastatin	 	chemical drug	 	-0.174	 	-0.100	0.150	1.43E-03	AGTRAP,BCL2L1,CXCL8,CYBA,EDN1,HMOX1,IL6,PLAT,PTGIS,PTGS2,THBD,TNFSF10	Ap1,ESR1,FOXO1,JUN,Jnk,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,fluvastatin	
P1	 	WISP2	0.036	growth factor	 	1.041	 	-0.084	1.350	1.44E-03	ADIPOQ,AXIN2,CD24,CTGF,ERBB2,ESR1,HIF1A,JUN,KRT8,PROCR,SDC4,SPARC,TFF3,TGFBR2,TGFBR3	Akt,Ap1,HIF1A,JUN,Jnk,NFkB (complex),RELA,STAT3,TP53,WISP2	
P1	 	deoxycholate	 	chemical - endogenous mammalian	 	0.568	 	-0.042	0.726	1.44E-03	CAV1,CXCL8,DDIT3,EGR1,GJB2,GLUL,HSPA5,IL6,LDLR,MCL1,PLAUR,PTGS2,SLC1A3,SMUG1,TNFRSF10B	ATF2,Ap1,EGFR,EGR1,ERK1/2,ESR1,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53,deoxycholate	
P1	 	PP2/AG1879 tyrosine kinase inhibitor	 	chemical - kinase inhibitor	 	-0.176	bias	-0.306	1.130	1.46E-03	BIRC3,CCL2,CTGF,CXCL16,CXCL8,DUSP1,EDN1,FGF2,FOS,GFPT1,HIF1A,HMOX1,ID1,IL6,ITGAM,LYN,PTGS2,SPP1,SRC,TJP1	Ap1,CREB1,ERK1/2,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PP2/AG1879 tyrosine kinase inhibitor,Pkc(s),RELA,SMAD3,SP1,SRC,STAT3	
P1	 	ABCB7	0.145	transporter	 	1.980	bias	0.301	1.384	1.46E-03	FECH,FTH1,TFRC,TXN	ABCB7,NFE2L2,VHL,iron	
P1	 	ADRA1	 	group	 	-1.969	bias	0.501	 	1.46E-03	ACTA1,EGR1,FOS,JUNB	ADRA1,CREB1,CREBBP,Ca2+,EGR1,EP300,ERK,ERK1/2,FOXO1,FOXO3,GATA4,JUN,MEF2C,MXI1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,phenylephrine	
P1	 	GCLM	1.130	enzyme	 	 	 	 	 	1.46E-03	FOS,GCLM,JUN,JUNB	 	
P1	 	PSMD4	0.307	other	 	0.000	bias	0.501	 	1.46E-03	CD14,CD36,CD69,MARCO	CXCL12,FOXO3,HIF1A,IL3,JUN,NFKB1,NFKBIA,NFkB (complex),PSMD4,RELA,STAT1,STAT3,STAT6	
P1	 	RTKN	1.143	other	 	-0.927	bias	0.501	 	1.46E-03	BCL2L1,BIRC3,FOS,TNFAIP3	JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RHOA,RTKN,STAT3,TP53	
P1	 	[Lys15,Arg16,Leu27]VIP(1-7)GRF(8-27)	 	chemical reagent	 	1.732	bias	-0.501	 	1.46E-03	CCL2,CD86,CXCL8,IL6	 	
P1	 	aclarubicin	 	chemical drug	 	 	 	 	 	1.46E-03	BCL2L1,MCL1,PTGS2,TNFRSF10B	 	
P1	 	oxytetracycline	 	chemical drug	 	-1.000	bias	0.501	 	1.46E-03	BMP2,BMP4,BMP6,ID1	 	
P1	 	ACO1	-0.009	enzyme	 	-1.067	bias	-0.334	-0.405	1.49E-03	ACO2,ALAS2,FTH1,GAPDH,IGFBP3,TFRC	ACO1,NFE2L2,VHL,iron	
P1	 	CEBPG	0.646	transcription regulator	 	0.152	 	0.167	-0.179	1.49E-03	ADH1C,ASNS,CXCL8,DDIT3,ELANE,IL6	CEBPA,CEBPB,CEBPD,CEBPG,CREBBP,HDAC4,JUN,NFkB (complex),PPARG,RNA polymerase II,XBP1	
P1	 	CNB-001	 	chemical reagent	 	0.816	bias	0.410	-0.188	1.49E-03	ASNS,ATF3,ATF4,DDIT3,PPP1R15A,SYN1	 	
P1	 	Collagen Alpha1	 	group	 	0.280	bias	0.401	-0.610	1.49E-03	CDH2,COL1A1,MMP2,MMP9,PLAUR,PTGS2	Ap1,CEBPA,CEBPB,Collagen Alpha1,Focal adhesion kinase,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RAC1,RELA,STAT1,STAT3,TP53	
P1	 	EPHX2	0.324	enzyme	Activated	2.200	 	-0.100	2.421	1.49E-03	CCL2,HEY1,HSPA5,IL6,NOTCH1,VCAM1	Ap1,EP300,EPHX2,ERK,HMOX1,IL1A,IL6,JUN,NFE2L2,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	hemoglobin	 	complex	 	-0.509	bias	0.410	-1.494	1.49E-03	ADM,CD163,CXCL8,EDN1,HMOX1,IL6	ATF6,Ap1,ESR1,ESR2,IL10,IL2,IL6,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARG,RELA,SP1,STAT1,STAT3,beta-estradiol,carbon monoxide,hemoglobin	
P1	 	fenamic acid	 	chemical reagent	 	1.569	bias	0.429	-0.281	1.49E-03	ADAMTS1,ASNS,BIRC3,CAPN6,CD14,EFEMP2,EMP3,GPNMB,GSTM3,IER3,LXN,MYC,PSMB10,RCN1,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	glucagon	 	biologic drug	 	-0.239	bias	0.255	-1.252	1.49E-03	AHNAK,CYBA,ESAM,FOS,LIMA1,LMNA,LRBA,MME,NR4A2,NR4A3,PHLDB2,PPP1R1A,PPP1R1B,RAP1GAP,TJP2,TNS1	CEBPB,CREB1,Creb,JUN,NFkB (complex),Pka,RELA,STAT1,STAT3,cyclic AMP,glucagon	
P1	 	hyaluronic acid	 	chemical - endogenous mammalian	 	0.022	 	0.194	-0.882	1.50E-03	BCL2L1,CCL3L3,CD86,COL6A2,CSF1R,CTSK,CXCL2,ERBB2,FOS,FST,IL6,JUN,LY96,MMP2,MMP9,NCF2,NFKBIA,NR4A2,PDCD4,PTGS2,SOCS3,SOX9,SPP1,TIMP1,TNFAIP3,VCAM1	Ap1,CREB1,CSF2,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TNF,hyaluronic acid	
P1	 	ERN1	0.817	kinase	 	-0.059	bias	0.282	-0.974	1.51E-03	ANG,CXCL2,CYP1B1,DDIT3,DGAT2,ETS1,GOT1,HSPA5,JUN,MCL1,MPZL2,NOX4,PVR,SLC7A1,SPARC,SYT11,TINAGL1,TNFRSF10B	ATF6,ATF6B,Ap1,ERN1,GSK3B,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,XBP1	
P1	 	MAP2K1/2	 	group	 	-1.320	bias	0.343	-2.744	1.51E-03	ARG2,ATF3,CCL3L3,CCND2,CTGF,DDIT3,DUSP1,EGR1,EGR2,ELN,FOS,HMOX1,HSPA5,JUN,MCL1,MMP9,MYC,PHLDA1	CEBPA,CEBPB,ERK,FOS,JUN,MAP2K1/2,MAPK1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TP53	
P1	 	flutamide	 	chemical drug	 	-0.251	 	-0.080	0.011	1.51E-03	ALAS2,AQP9,COL3A1,CXCL2,CYP11A1,CYP1B1,CYP4B1,CYR61,ESR1,FOS,GSTM1,HIF1A,IL6,KDR,ME1,NQO1,ODC1,SRD5A1	AR,Akt,Ap1,CREB1,ESR1,ESR2,HIF1A,JUN,NCOR1,NFKB1,NFKBIA,NFkB (complex),NR3C1,POMC,RELA,SP1,STAT3,TNF,TP53,beta-estradiol,flutamide	
P1	 	lipoteichoic acid	 	chemical - endogenous non-mammalian	 	-0.284	bias	0.413	-1.881	1.51E-03	ANTXR1,BCL2L1,CAST,CCL2,CCR1,CD14,CD86,CXCL8,CXCR4,HIF1A,HMOX1,IL6,MMP2,MMP9,NLRP3,NR4A2,NR4A3,PTGS2	CEBPA,CEBPB,IL10,IL1B,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TLR4,TP53,lipoteichoic acid	
P1	 	ATF6	0.586	transcription regulator	 	1.598	bias	0.371	0.090	1.51E-03	ATP2A2,DDIT3,DNAJB11,FOS,HSPA5,IL6,MCL1,NUCB2,PLIN2,PRNP,PVR,RAN,RCAN1,SLC35B1,SPARC,TNFRSF10B,UNC13B	APP,ATF6,CEBPA,CEBPB,CTNNB1,DDIT3,FOXO1,HDAC1,HIF1A,JUN,MTOR,NFAT (complex),NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,STAT1,STAT3,Vegf	
P1	 	Ifn gamma	 	complex	 	-0.768	bias	0.287	-2.030	1.53E-03	AGT,BCL2L1,CCL2,CD86,COL1A1,CSE1L,CXCL16,CXCL8,EDN1,ESR1,GBP1,IGFBP4,LY96,MAP4K4,MMP9,MYC,NR4A3,PCDH7,PSME2,SOCS3,TNFSF10,VSIG4,XAF1	Ap1,IFNG,IRF8,Ifn gamma,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TNF	
P1	 	miR-125b-5p (and other miRNAs w/seed CCCUGAG)	 	mature microrna	 	-0.207	bias	-0.501	 	1.53E-03	ADAMTS1,AJUBA,BMF,C10orf54,CBX7,CDH5,CEBPG,DUS1L,ERBB2,GPR160,GSS,H3F3A/H3F3B,ID1,ID3,IGFBP3,JUN,PERP,RABL6,SGPL1,SMO,UBE2I,UVRAG,VPS4B	 	
P1	 	trinitrobenzenesulfonic acid	 	chemical reagent	 	0.567	bias	0.406	-1.246	1.53E-03	CCL3L3,CCR1,CD68,COL1A1,COL1A2,COL3A1,CSF2RA,CXCL2,CYP11A1,FOS,IDO1,IL6,ITGAM,LUM,MMP9,PTGDS,PTGS2,PTX3,S100A8,S100A9,SOCS3,TIMP1,TNFRSF12A	AR,Ap1,FOXO3,HIF1A,IFNG,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NOS2,NR3C1,NR3C2,RELA,STAT1,STAT3,corticosterone,trinitrobenzenesulfonic acid	
P1	 	ITGB1	-0.458	transmembrane receptor	 	-1.233	 	0.154	-1.917	1.61E-03	ABCC1,ACTA1,APOE,CCL2,COL1A1,COL1A2,CXCL8,EIF4EBP1,ERBB2,FLNA,FOS,IL6,JUN,JUNB,LIMS1,MMP2,MMP9,MYC,PLAUR,PTGS2,THBS1,TNFAIP3	ATF2,Ap1,EGFR,FN1,FOS,ITGB1,JUN,MAPK8,NFKB1,NFKB2,NFkB (complex),PRKCD,RELA,SMAD3,SP1,SRC,STAT3	
P1	 	Hsp70	 	group	 	-0.750	 	0.178	-1.370	1.61E-03	BCL2L1,CD14,CD86,CXCL8,GAPDH,HCST,HIF1A,HRAS,IL6,NFKBIA,SELE,TYROBP,VCAM1	Ap1,Hsp70,IL10,JUN,MYD88,NFATC2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TLR4,TP53	
P1	 	RUVBL1	0.517	transcription regulator	 	0.466	bias	0.501	 	1.61E-03	AXIN2,C9orf9,CARS,CCND2,ERGIC1,ETS1,GADD45B,HIST2H2AC,IGFBP3,KIFC2,SESN2,SRD5A1,TMEM19	 	
P1	 	TXN	1.353	enzyme	 	-0.399	 	0.125	-0.801	1.61E-03	ACADM,CCND2,CD86,CXCL8,CYP1B1,ESR1,FOS,HIF1A,HMOX1,IL6,MMP9,NFKBIA,TXN	JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53,TXN	
P1	 	valsartan	 	chemical drug	 	-0.800	bias	-0.290	0.186	1.61E-03	ADIPOQ,COL1A1,CYBA,DLG4,EDN1,FGF2,FOS,KIT,LEP,MMP2,PTGS2,SPP1,TIMP1	AGT,AGTR1,Ap1,ESR1,FGF2,HNRNPK,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53,valsartan	
P1	 	zoledronic acid	 	chemical drug	 	-1.575	 	-0.209	-0.953	1.63E-03	BCL2L1,CXCL8,CXCR4,CYR61,FZD5,IL6,LPAR1,MMP2,MMP9,PTGS2,TNFSF10	AKT1,Akt,Ap1,CEBPA,CEBPB,HIF1A,JUN,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,STAT3,TP53,fluvastatin,prostaglandin E2,zoledronic acid	
P1	 	resiquimod	 	chemical drug	 	-1.262	bias	0.319	-2.615	1.67E-03	ATF3,ATP6V1B2,CASP4,CAT,CCL2,CCL3L3,CD86,CMTM8,CREB5,CXCL12,CXCL2,CXCL8,ETS2,FCER2,FGF2,GDF15,GM2A,GNG2,HEY1,IER3,IL6,IRAK1,JUN,KCNMA1,LMNA,MCL1,NFKBIA,NFKBIZ,PKM,PLAT,PSMB2,PTGS2,PTX3,SPP1,TNFSF10,WARS	Ap1,IFNG,IL1B,JUN,MYD88,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53,resiquimod	
P1	 	STAT1	-0.342	transcription regulator	 	-0.725	bias	0.352	-2.906	1.68E-03	AGT,ALAS2,ALDH1A3,APOE,AXL,BCL2L1,BTG1,CASP4,CCL2,CCL3,CCL3L3,CCND2,CCND3,CD14,CD86,CEBPD,CFB,CH25H,CSF3R,CXCL8,CYP2C8,EDN1,EGR1,FAM26F,FCER1G,FGF2,FOS,GBP1,HEY1,HIF1A,IDO1,IFI27,IFIT2,IL6,JUN,LY6E,LY96,MMP9,MYC,PCDH17,POMC,PRKCE,PSMB10,PSME2,PTGS2,RUNX1,SERPINA3,SMAD7,SMARCB1,SOCS3,SP110,TNFRSF10B,TNFSF10,TYMP,WARS	CEBPA,CEBPB,ERK1/2,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	GSK3B	0.601	kinase	 	-0.338	 	-0.058	-0.085	1.69E-03	ATP2A2,BCL2L1,BIRC3,CCL2,DDIT3,EMD,ESR1,FOS,HIF1A,IL6,IRS2,KIF3B,MCL1,MMP9,MYC,NFKBIZ,PMP22,PTGS2,RND2,SH3GLB1,SPP1,SYN1,TNFRSF10B,TNFSF10	Akt,Ap1,CEBPA,CEBPB,ERK1/2,GSK3B,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	plicamycin	 	chemical drug	 	0.870	 	-0.189	1.777	1.69E-03	AVPI1,AXL,BNIP3L,CCL2,COL1A1,COL1A2,CTGF,GFRA2,GJB2,HIF1A,HMOX1,ID1,IGFBP4,KDR,MAOA,MIF,PLAUR,PPP1R1B,PRKCD,SERPINE2,SOCS3,TGFBR2,TIMP1,TYMP	Ap1,EGR1,ESR1,HDAC1,Histone h3,MYC,NFkB (complex),RELA,RNA polymerase II,SMAD1,SMAD3,SMAD4,SP1,SP3,STAT3,Smad,TGFBR2,TP53,TP73,plicamycin	
P1	 	DEK	-0.327	transcription regulator	 	 	 	 	 	1.73E-03	BIRC3,CSF3R,CXCL8,MCL1,NFKBIA	DEK,HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P1	 	PLA2G5	0.559	enzyme	 	0.483	bias	0.501	 	1.73E-03	COL1A2,COL3A1,PLA2G5,PTGS2,VEGFC	ATF2,ERK1/2,FOS,JUN,MAPK1,NFKBIA,NFkB (complex),PLA2G5,PPARA,PPARG,RELA,SMAD3,SP1,SREBF1,STAT1,STAT3,arachidonic acid	
P1	 	PMP22	-0.501	other	 	 	 	 	 	1.73E-03	APOE,CSPG4,EMP3,FLOT1,PMP22	 	
P1	 	acetic acid	 	chemical - endogenous mammalian	Inhibited	-2.196	bias	0.376	-3.022	1.73E-03	EGR1,FOS,JUN,JUNB,LEP	Ap1,ERK,JUN,NFkB (complex),RELA,SMAD3,SMAD4,STAT3,Tgf beta,acetic acid	
P1	 	allyl isothiocyanate	 	chemical toxicant	 	 	 	 	 	1.73E-03	FOS,HMOX1,MMP2,MMP9,PTGS2	ADM,Ap1,BCL2,CREB1,ERK1/2,FOS,JUN,MAPK8,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,SP1,STAT3,TP53,allyl isothiocyanate	
P1	 	aplidine	 	biologic drug	 	-1.452	bias	0.376	-2.276	1.73E-03	DUSP1,FOS,FOSB,JUN,JUNB	ATF2,Ap1,EGFR,FOS,HIF1A,JUN,Jnk,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,RAC1,RELA,SMAD3,SP1,STAT3,aplidine	
P1	 	ciclopirox olamine	 	chemical drug	 	0.000	 	0.000	0.000	1.73E-03	AXIN2,BCL2L1,CDK4,HIF1A,TF	ARNT,Ap1,BCL2,HIF1A,MYC,NFKBIA,NFkB (complex),PPARG,SP1,TP53,VHL,ciclopirox olamine	
P1	 	fingolimod phosphate	 	chemical - endogenous mammalian	Inhibited	-2.236	bias	0.376	-3.077	1.73E-03	CCL2,CTGF,ERN1,IL6,THBS1	Ap1,ELK1,FOS,JUN,MAPK3,NFkB (complex),Nr1h,RXRA,STAT1,STAT3,fingolimod phosphate	
P1	 	oleoylethanolamide	 	chemical - endogenous mammalian	 	-0.074	 	0.125	-0.345	1.73E-03	BCL2L1,CD36,FOS,FOSB,SLC27A1	AKT1,Akt,Ap1,ERK1/2,FOXO1,Growth hormone,HIF1A,Insulin,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53,oleoylethanolamide	
P1	 	saikosaponin A	 	chemical reagent	 	-1.980	 	0.215	-2.405	1.73E-03	BMP4,CDKN2B,FOS,JUN,JUNB	ATF2,Ap1,ERK,ESR1,FOS,JUN,MAPK1,NFATC2,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,STAT1,STAT3,saikosaponin A	
P1	 	Collagen(s)	 	complex	 	1.643	 	0.156	1.132	1.73E-03	ATF4,C5AR1,CD55,CD68,CYR61,DDIT3,EDEM1,IARS,ITGAM,LAMP2,PPP1R15A,PSAT1,SERPINH1,THBS1	CEBPA,CEBPB,CREB1,Collagen(s),FOS,JUN,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT1,STAT3,TP53	
P1	 	LPL	-0.330	enzyme	 	-1.016	 	0.152	-1.541	1.73E-03	ADIPOQ,APOB,CCL2,CD36,CXCL8,GBP1,IL6,IRS2,LDLR,PDK4,SELE,SLC27A1,THBS1,VCAM1	ADIPOQ,Ap1,D-glucose,HIF1A,LDL,LPL,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,SREBF1,SREBF2,STAT3,cholesterol,fatty acid	
P1	 	PPRC1	0.610	transcription regulator	 	-1.664	bias	0.501	 	1.73E-03	AADAC,ATF4,BMP6,CXCL8,DDIT4,DUSP5,GDF15,GNG11,NFKBIZ,PHLDA1,PTGS2,SPX,ST6GALNAC3,TM6SF1	 	
P1	 	apigenin	 	chemical - endogenous non-mammalian	 	0.014	bias	-0.358	1.422	1.74E-03	CCL2,CCL3L3,CCND2,CDK4,CXCL8,DGAT2,DVL2,DVL3,FOS,GCLM,HIF1A,HMOX1,IL6,MMP9,PTGS2,SELE,SLC27A1,TAGLN,TNFRSF10B,VCAM1	Akt,CAT,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53,apigenin	
P1	 	IL11	-0.001	cytokine	 	0.317	 	0.100	-0.007	1.81E-03	BCL2L1,CEBPD,CXCL8,F8,FOS,IL6,JUNB,LBP,POMC,SERPINA3,SMAD6,SOCS3,SPP1,TIMP1,VCAM1	CEBPA,CEBPB,ELK1,ERK1/2,FOS,IL11,IRF8,JUN,MAPK3,NFKBIA,NFkB (complex),RELA,SMAD3,STAT,STAT1,STAT3,TP53	
P1	 	CCR1	0.501	g-protein coupled receptor	 	0.240	 	0.221	-0.449	1.82E-03	ATF4,CCL3L3,CCR1,CTSK,FOS,ITGAM,MMP2,MMP9,SPARC,SPP1	CCL5,CCR1,CREB1,ERK,IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TNF	
P1	 	CSF1R	0.878	kinase	 	-1.463	bias	0.456	-2.745	1.82E-03	CCL3L3,CCND2,CSF1R,FOS,IL6,JUN,JUNB,MYC,SPI1,VCAM1	Ap1,CSF1,CSF1R,ELK1,ERK1/2,FOS,JUN,MAPK3,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,SPI1,STAT1,STAT3	
P1	 	JAK	 	group	 	0.128	bias	0.279	-0.478	1.82E-03	CCL2,CD209,HES6,HIF1A,IL6,MMP9,PTGER4,PTGS2,SOCS2,SOCS3	Ap1,CEBPA,CEBPB,IL10,IRF8,JAK,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53	
P1	 	hemozoin	 	chemical - endogenous non-mammalian	 	-1.343	bias	0.501	 	1.82E-03	CCL2,CCL3,CCL3L3,CCR1,CXCR4,HMOX1,IL6,MMP9,S100A8,S100A9	ERK1/2,IL10,IL1B,IL6,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,hemozoin	
P1	 	MAP2K7	0.118	kinase	 	-1.452	 	0.209	-1.910	1.84E-03	ATF3,BIRC3,CSTA,CXCL8,EFNB2,ENPP2,ERCC1,FCGRT,HSPA5,JUNB,LSP1,MYC,P2RX4,PLA2G4A,RHOB,TFPI2	ATF2,Ap1,FOS,JUN,MAP2K7,MAP3K1,MAPK1,MAPK9,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3	
P1	 	telmisartan	 	chemical drug	 	1.330	 	-0.053	1.533	1.84E-03	ADIPOQ,AGT,APLNR,CCL2,CD163,CLEC10A,CTGF,CYR61,IL6,LEP,MMP9,NR4A2,PLA2G5,PLIN1,PRMT1,PTGS2	EP300,FOXO1,Growth hormone,HIF1A,Insulin,NADPH oxidase,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,aldosterone,palmitic acid,telmisartan	
P1	 	thioctic acid	 	chemical drug	 	-0.231	 	-0.215	0.557	1.84E-03	ABCC1,CAT,CCL2,CXCL8,FOS,HMOX1,IL6,JUN,LEP,MMP2,MMP9,MYC,NQO1,SELE,UCP2,VCAM1	Akt,Ap1,ESR1,FOS,HIF1A,JUN,Jnk,MAPK8,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,STAT3,TP53,thioctic acid	
P1	 	Nr1h	 	group	Activated	2.923	 	-0.185	3.930	1.85E-03	ABCG1,ACACA,ACSL3,AGT,ALDH1A1,ALDH1A2,APOC1,APOE,ARG2,BMP6,C2,CAV1,CCL3,CCL3L3,CCND2,CXCL8,EDN1,EDNRA,FECH,HLA-DOA,IL6,NFKBIZ,NLRP3,NR5A2,PLA2G2A,PLTP,PTGS2,RGN,SFRP1,SP110,THBS1,THY1	Ap1,CEBPB,ESR1,IRF8,JUN,NFATC2,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),Nr1h,PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF2,STAT1,STAT3,THRB,cholesterol	
P1	 	IL10RA	0.544	transmembrane receptor	 	-0.983	 	0.016	-1.110	1.88E-03	AADAC,ABCG1,ADH1C,ALDH2,ANO1,ARG2,ASS1,BMP2,BMP4,CACHD1,CBS/CBSL,CD36,CD69,CFB,CLCN7,CSF3R,CYR61,DDIT4,DPT,EDN1,F13A1,FADS3,FAM26F,FHL1,FOLR2,GSAP,GSDMC,GSTM1,GSTM2,GSTM5,HCAR2,HSPA8,IL6,LMO4,LUM,MECOM,MECR,MLKL,MMP25,MSRB1,NPL,NR5A2,OGN,PCOLCE,PMP22,PROCR,S1PR1,SCIN,SLAMF8,SLC2A6,SLCO2B1,SOCS3,SPARC,SPON1,ST3GAL6,ST6GALNAC2,TGM2,THBS4,TNFRSF14,UPP1	IL10RA,IRF8,JUN,NFKBIA,NFkB (complex),STAT1,STAT3	
P1	 	PLAUR	-0.525	transmembrane receptor	 	0.497	bias	0.349	-0.593	1.88E-03	ANG,BCL2L1,C5AR1,CCL2,CDK4,CTSB,ITGAM,KDR,MMP2,MMP9,MYC,PLAUR	CEBPA,CEBPB,ERK1/2,FN1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PLAUR,RELA,SMAD3,SP1,SRC,STAT1,STAT3,TP53	
P1	 	STAT	 	group	 	-0.986	bias	0.501	 	1.88E-03	AGT,BCL2L1,CEBPD,FOS,JUNB,LBP,POMC,SERPINA3,SMAD7,SOCS2,SOCS3,TIMP1	AKT1,ERK,JUN,NFKB1,NFkB (complex),RELA,SMAD3,SP1,STAT,STAT1,STAT3,TP53	
P1	 	XDH	-0.017	enzyme	 	-0.532	 	-0.072	-0.291	1.88E-03	ABCG1,CD69,CTGF,CXCL8,CXCR4,DUSP1,DUSP10,HIF1A,ID3,MMP2,PLAUR,SPP1	Ap1,CREB1,CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,SP1,SRC,STAT3,XDH,xanthine	
P1	 	HDAC1	-0.040	transcription regulator	 	-0.857	 	-0.067	-0.491	1.89E-03	ADIPOQ,AKAP12,ATF3,ATG7,AXIN2,BAMBI,BMF,CCND2,CD4,COL1A2,CSF1R,CTSK,CXCL8,EGR1,ESR1,FAM107A,FOS,GABARAPL1,GLUL,GSK3B,ID1,IL6,KDR,LHCGR,LIG1,MMP9,MT1G,MYC,NCL,NFKBIA,PFKFB3,POLD2,PRAG1,PTGS2,RHOB,RRM2B,S100A9,SDPR,SFRP1,SGK1,SOX9,SPP1,SQSTM1,TAGLN,TGFBR2,TGM2,TNFRSF19,TNS1,VHL	Ap1,ESR1,HDAC1,HDAC2,Hdac,Histone h3,Histone h4,MYC,NFkB (complex),NR3C1,RELA,RNA polymerase II,SIN3A,SP1,STAT3,TP53,TP73,histone deacetylase	
P1	 	DDR1	-0.450	kinase	 	0.456	 	0.167	0.024	1.90E-03	BCL2L1,COL1A1,COL3A1,ELN,MMP2,MMP9,VCAM1	CEBPA,CEBPB,CTNNB1,DDR1,ERK,GATA1,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,STAT1,STAT3,TP53,imatinib	
P1	 	EDNRA	-0.665	transmembrane receptor	 	1.408	bias	0.501	 	1.90E-03	COL1A1,COL3A1,FOS,ITGAM,MMP2,PTGS2,TIMP1	ARRB2,Ap1,CREB1,EDNRA,FOS,JUN,MAPK1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,STAT3,TP53,histamine	
P1	 	Go6983	 	chemical - kinase inhibitor	 	1.937	bias	-0.301	2.726	1.90E-03	ACADM,CD36,CTGF,FOS,PRKCD,PRKCE,PTGS2	Akt,CREB1,FOS,Go6983,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PRKCE,Pkc(s),RELA,SP1,SRC,STAT1,STAT3,TP53	
P1	 	IGFBP7	-0.247	transporter	 	-0.640	 	0.116	-0.922	1.90E-03	ASNS,CYP11A1,DVL3,MMP2,MMP9,MYC,PTGS2	Akt,Ap1,ELK1,ERK,FOS,HIF1A,IGFBP7,JUN,MAPK3,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TP53,heparin,hyaluronic acid	
P1	 	NREP	1.252	other	 	-0.277	 	0.167	-0.713	1.90E-03	COL3A1,FGF2,ITGA3,MMP2,MMP9,TAGLN,TGFBR2	HIF1A,JUN,NFkB (complex),NREP,RAC1,RELA,STAT3	
P1	 	PD 0325901	 	chemical drug	 	1.530	 	0.143	1.180	1.90E-03	CXCL8,DDIT4,ERCC1,MCL1,MYC,TSC2,VCAM1	Akt,ERK,HIF1A,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD 0325901,RELA,SMAD3,SRF,STAT1,STAT3,TP53	
P1	 	PLC	 	group	 	-1.890	bias	0.418	-2.995	1.90E-03	CCL2,CXCL8,EGR3,FOS,LIPE,MYC,ODC1	ERK,FOXO1,Growth hormone,HIF1A,Insulin,JUN,NFKB1,NFKB2,NFkB (complex),PLC,PPARA,PPARG,PRKCD,PRKCE,RELA,SMAD3,SP1,SRC,STAT1,STAT3	
P1	 	PTAFR	-0.069	g-protein coupled receptor	 	-0.316	 	0.215	-0.827	1.90E-03	CCL2,CCL3L3,CDH2,CXCL2,CXCL8,IL6,PTGS2	Creb,FOS,JAK2,JUN,MAPK1,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PTAFR,RELA,SP1,STAT1,STAT3,STAT5a/b,platelet activating factor	
P1	 	RPS6KA5	-0.386	kinase	 	-1.667	 	0.143	-2.013	1.90E-03	DUSP1,FOS,IL6,JUN,JUNB,MYC,PTGS2	CEBPB,CREB1,CREBBP,CREM,CTNNB1,Creb,EP300,HIF1A,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RPS6KA5,SP1,STAT1,STAT3,TP53	
P1	 	dexmedetomidine	 	chemical drug	 	1.000	bias	-0.270	1.651	1.90E-03	CCL2,CXCL8,DDIT4,FOS,FOSB,IL6,PTGS2	Akt,ERK1/2,FOS,HIF1A,IL4,JUN,MAPK1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT6,TP53,dexmedetomidine,prostaglandin E2	
P1	 	trastuzumab	 	biologic drug	 	-1.738	 	-0.033	-1.652	1.90E-03	BCL2L1,BNIP3L,CXCL8,ERBB2,IL6,MYC,PDCD4	Akt,EGR1,ELK1,ERBB2,FOS,FOXO1,FOXO3,HIF1A,JUN,MAPK3,MXI1,MYC,NFKB1,NFkB (complex),PTEN,SP1,STAT3,TP53,estrogen receptor,trastuzumab	
P1	 	L-glutamic acid	 	chemical - endogenous mammalian	Inhibited	-2.084	bias	0.281	-3.389	1.97E-03	ACLY,BCL2L1,CDH2,CIDEC,EGR1,FGF2,FMO2,FOS,FOSB,GADD45B,HEXA,JUN,JUNB,LEP,MAP1B,PLIN2,POMC,PTGS2,SLC1A3,SLC27A1,SORBS1,SORL1,TIMP1,TSC2	AKT1,ELK1,FOS,IL1B,JUN,L-glutamic acid,LEP,MAPK3,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT1,STAT3,TNF,TP53	
P1	 	olanzapine	 	chemical drug	 	-0.604	 	0.149	-1.311	1.97E-03	ACKR2,AOX1,ATF3,COL1A2,CYP11A1,DBP,FOS,GSK3B,HLA-G,HMGCS1,HMOX1,HSPA8,LDLR,NR4A2,NR4A3,PLA2G4A,PPP2R1A,RELN,S100A8,S100A9,SLC24A3,SLC38A1,SPRY2,THBD	ADRA1D,Ap1,CEBPA,CEBPB,FOS,FOSL1,JUN,LEP,MAP2K1/2,MAPK1,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,TP53,olanzapine	
P1	 	KN-62	 	chemical - kinase inhibitor	 	0.426	bias	-0.414	1.663	1.97E-03	ATF3,CXCL8,DDIT3,EGR1,IL6,MMP9,PPP1R15A,PTGS2,VCAM1	Ap1,CHUK,IKBKB,IL1B,JUN,Jnk,KN-62,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P1	 	epicatechin gallate	 	chemical drug	 	1.276	 	0.125	0.949	1.97E-03	CXCL8,GDF15,IL6,LYN,MGMT,PERP,PTGS2,VCAM1,ZMAT3	Ap1,ESR1,HIF1A,JUN,Jnk,NFATC2,NFKB1,NFKB2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,PRKCD,RELA,STAT3,epicatechin gallate	
P1	 	evodiamine	 	chemical - endogenous non-mammalian	 	0.333	bias	-0.358	1.408	1.97E-03	BCL2L1,BIRC3,CXCL8,LIPE,MCL1,MMP9,MYC,PTGS2,SELE	Akt,ERK,HDAC3,HIF1A,IKK (complex),JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TP53,evodiamine	
P1	 	PPARD	0.179	ligand-dependent nuclear receptor	 	0.831	 	0.240	-0.573	1.98E-03	ACADVL,ADORA1,ALDH2,ALDH3A2,ANGPTL4,APOB,APOE,C10orf35,C1QA,C1QB,C1QC,CCND2,CD36,CD68,CDK4,CLEC4F,CSAD,FBP1,GOT2,GPAM,IL6,INHBE,LIPE,LIPG,LPIN2,MMP9,MYOM2,PDK4,PLA2G2A,PLIN2,PTGS2,RABL6,SERINC2,SLC27A1,SORD,TCEA3,THBS1,TNFRSF12A,UCP2	Ap1,CEBPB,EP300,GW501516,JUN,NFKB1,NFkB (complex),PPARA,PPARD,PPARG,RXRA,SMAD3,SREBF1,STAT3,bezafibrate,eicosapentenoic acid,fatty acid	
P1	 	DPP-23	 	chemical reagent	 	0.788	bias	0.501	 	2.02E-03	ATF4,DDIT3,DNAJB2,DNAJB4,ERN1,HSPA1A/HSPA1B,HSPA5,PPP1R15A	 	
P1	 	MNT	0.451	transcription regulator	 	1.000	bias	-0.501	 	2.02E-03	CCND2,CCNG2,CDK4,DDIT3,GADD45B,KLF6,NCL,ODC1	 	
P1	 	NADPH oxidase	 	complex	 	0.294	bias	0.324	-0.603	2.02E-03	CCL2,FOS,HMOX1,IL6,JUN,MMP9,PTGS2,VCAM1	ATF2,Akt,Ap1,HIF1A,JUN,Jnk,NADPH oxidase,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SREBF1,STAT3,TP53,arachidonic acid	
P1	 	SP100	0.286	transcription regulator	 	 	 	 	 	2.02E-03	AXIN1,CD14,CTGF,GABRE,HSPA8,HSPE1,SRD5A1,THY1	CREB1,EP300,ETS1,HDAC1,RNA polymerase II,SP100,TP53	
P1	 	TNFRSF18	0.108	transmembrane receptor	 	-0.263	 	0.088	-0.510	2.02E-03	BCL2L1,CCL2,CCL3L3,CXCL8,IDO1,IL6,MMP9,PTGS2	IL2,IRF8,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,STAT1,STAT3,TNFRSF18	
P1	 	dipyridamole	 	chemical drug	 	-0.896	bias	-0.324	-0.107	2.02E-03	CCL2,HMOX1,IL6,MMP2,MMP9,PTGS2,SPP1,TIMP1	5-hydroxytryptamine,Ap1,CREBBP,CTNNB1,Creb,EP300,FOXO3,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SPP1,STAT1,STAT3,TP53,dipyridamole,nitric oxide	
P1	 	hydroxypropyl-beta-cyclodextrin	 	chemical drug	 	-0.841	 	-0.185	-0.327	2.02E-03	ABCG1,CCL3L3,CD68,CTSB,CTSD,GUSB,LDLR,SQSTM1	NFE2L2,NFkB (complex),RELA,SREBF2,STAT3,cholesterol,hydroxypropyl-beta-cyclodextrin	
P1	 	D-galactosamine	 	chemical - endogenous mammalian	 	-0.971	bias	0.422	-2.403	2.07E-03	CD14,CTSB,CXCL2,EDNRA,FOS,GDF15,IL6,JUN,JUNB,MCL1,MYC,TIMP1,TNFSF10	D-galactosamine,IFNG,IL10,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF	
P1	 	IRF6	0.092	transcription regulator	 	-1.132	bias	0.449	-2.590	2.07E-03	CCL2,CD14,CDH2,CXCL8,ENPP2,IL6,KLF4,NLRP3,NR4A2,P2RX4,PTGS2,SLC7A2,TJP1	CEBPB,HIF1A,IRF6,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TLR4,cyclic AMP,reactive oxygen species	
P1	 	ELAVL1	0.151	other	 	0.445	bias	0.363	-0.492	2.07E-03	ARF5,ARG2,ATF3,CCL8,DUSP1,EIF4E2,FLNA,FOS,GSS,HMOX1,HOMER2,HSPA2,IL6,MYC,NCL,PCOLCE,PTGS2,RPN2,TRIOBP,ZFP36	Ap1,CTNNB1,ELAVL1,HIF1A,JUN,MMP9,MYC,NFKB1,NFKBIA,NFkB (complex),NOS2,NOTCH1,P38 MAPK,RELA,STAT3	
P1	 	KLF4	-2.287	transcription regulator	 	0.218	bias	0.282	-1.560	2.08E-03	ALCAM,ALDH1A1,ALPL,ANGPT1,APCDD1,AXIN1,BMPER,CCND2,CD14,CDKN2B,CNFN,COBLL1,COL1A1,COL8A1,CRABP2,CSF1R,CXCL8,DUSP1,DUSP5,EMX2,EVPL,FARP1,FRZB,GBP4,GJB2,HEY1,HEY2,ID3,IL6,IRX3,ITGAM,KDR,KLF4,MYH11,NOTCH1,NRP1,ODC1,PLAUR,SERPINH1,SLC4A7,SOX17,TAGLN,TF,TNFRSF19,TXNRD1,ZFP42	Ap1,CREBBP,CTNNB1,EGR1,EP300,ESR1,HDAC1,HIF1A,Histone h3,JUN,KLF4,NFkB (complex),RELA,RNA polymerase II,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TCF,TP53	
P1	 	2-amino-5-phosphonovaleric acid	 	chemical - other	Activated	3.644	 	0.068	3.267	2.09E-03	AAGAB,ADAMTS1,ATF4,BTG3,CDK20,DCLK2,DUSP1,EGR1,EGR2,EGR3,FOS,FOSB,GADD45A,GADD45B,HGH1,IFRD1,JUN,JUNB,KDR,LHFPL2,MED20,MLST8,NAB1,NR4A2,NR4A3,PHLDA1,PTGS2,SDPR,SMG7,STOML1,TNFAIP3,ZNF605	2-amino-5-phosphonovaleric acid,5-hydroxytryptamine,Ap1,CREB1,FOS,FOXO3,FSH,HDAC4,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,nitric oxide	
P1	 	ID2	-0.347	transcription regulator	 	-1.091	 	-0.057	-0.830	2.13E-03	BCL2L1,CCND2,CCNG2,CDK20,CDK4,CDKN2C,CXCR4,DUSP1,DUSP10,DUSP22,EGR2,ETS2,FCER1G,G6PC3,GADD45B,HIF1A,HOMER2,IL10RA,IL20RB,ITGA1,KLF6,LMO4,MAF,MAPK7,MYC,NOTCH1,NR4A3,PIK3C2B,PTPN3,RAP1GAP,SMAD7,SOCS3,TF,TGFBR3,TNFRSF4,TNFSF10,TOX2	Akt,EP300,HIF1A,ID2,ID3,JUN,MYOD1,NFkB (complex),RNA polymerase II,SIRT1,SMARCA4,STAT3,STAT5a/b,TAL1,TCF3,TP53	
P1	 	PIK3R1	-0.118	kinase	 	1.040	bias	0.339	-0.348	2.14E-03	ATF5,BCL2L1,CCL3,CCND2,COL1A2,CXCL8,DDIT3,FOS,HIF1A,HMOX1,IL6,MMP2,MYC,NFE2L1,PIK3R2,PKM,PTGS2,VCAM1,VEGFC	Ap1,HIF1A,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PIK3R1,RAC1,RELA,SP1,SRC,STAT1,STAT3,STAT6	
P1	 	chloroquine	 	chemical drug	 	1.688	 	-0.033	1.808	2.18E-03	BCL2L1,CD69,CD86,CTSD,CXCL8,HIF1A,IL6,PRNP,RCAN1,S1PR1,SELE,SOCS3,SQSTM1,TXN	26s Proteasome,APP,CEBPB,HIF1A,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,TP53,chloroquine	
P1	 	4-hydroxynonenal	 	chemical toxicant	 	-1.709	 	0.234	-2.396	2.19E-03	AKR1B1,BCL2L1,CD36,CTGF,CTSB,HSPA1A/HSPA1B,IL6,JUN,MME,MMP9,PTGS2	4-hydroxynonenal,APP,Akt,D-glucose,EP300,ERK1/2,HIF1A,JUN,MYC,NADPH oxidase,NFKBIA,NFkB (complex),PPARG,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	STAT6	-0.012	transcription regulator	 	1.091	 	0.146	0.239	2.20E-03	ACP5,ALDH2,ANO1,APOE,APOLD1,BCL2L1,CCDC86,CCL2,CCL3L3,CCL8,CCND2,CD69,COBLL1,COL1A1,COL1A2,CRIP1,CTNS,CTSB,EGR1,EGR2,EPHX1,FCER1G,FCER2,FCGR3A/FCGR3B,FLRT2,FNIP2,GADD45B,GNA15,GPM6B,HIPK2,IER2,IFNAR2,IL10RA,IL6,IRS2,ISG20,LPIN2,MAF,MMP2,MMP28,MMP9,NEDD9,NFKBIA,PRNP,PTGS2,SAMD4A,SELE,SOCS2,SQSTM1,TFF3,TLE1,VCAM1,ZFP36	IFNG,IL10,IL4,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,STAT6,TNF	
P1	 	linoleic acid	 	chemical - endogenous mammalian	 	0.347	 	0.167	-0.311	2.21E-03	ACADM,ACSL4,APOB,DDIT3,DUSP1,EDN1,HSPA5,IL6,KDR,LDLR,NEDD4L,NFKBIA,PLIN2,PTGS2,S100A8,S100A9,UCP2,VCAM1	CREB1,Ca2+,FOS,FOXO1,IL1B,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,Pkc(s),RELA,RXRA,SP1,SREBF1,STAT3,TP53,fatty acid,linoleic acid	
P1	 	NRIP1	-0.342	transcription regulator	 	-0.403	bias	-0.288	0.442	2.25E-03	ACACA,ACO2,CCNG2,CIDEA,CRABP1,CYP2C8,CYP4B1,IL6,MMD,OPLAH,OTUB2,PDK4,PTGS2,PTX3,SLC25A19,SMAD6,THRSP	ESR1,ESR2,JUN,NFKB1,NFkB (complex),NRIP1,RELA,SP1,STAT3,beta-estradiol	
P1	 	TSH	 	complex	 	-0.746	bias	0.324	-1.927	2.27E-03	CCND3,CXCL8,EGR1,ERP29,FOS,FTH1,GAPDH,GNAI1,IGFBP3,IL6,JUNB,KDR,MYC,NOX4,SOCS3,TPO	Ap1,CEBPB,ERK1/2,FOS,JUN,MAPK8,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TSH,cyclic AMP,phorbol myristate acetate	
P1	 	mir-1	0.107	microrna	 	-0.915	bias	-0.433	1.268	2.29E-03	ADPGK,CAPRIN1,CCL2,CCND2,CXCL8,EDN1,ESR1,GATAD2A,H3F3A/H3F3B,HACD3,KIF2A,MAN1C1,MMP9,MTX1,MYLK,PDCD4,RNF38,RRBP1,SEC61A1,SFRP1,SLC25A1,SOX9,STX6,SULF1,VEGFC,XPO6	CCL11,IL5,NFkB (complex),STAT3,STAT5A,STAT5B,STAT5a/b,mir-1	
P1	 	MTPN	0.370	transcription regulator	 	-0.562	bias	0.501	 	2.33E-03	BCL2L1,CCND2,CCND3,COL1A1,COL1A2,COL8A1,EDN1,FOS,H6PD,IL6,JUN,MIF,MYC,MYH1,PLAT,S100A8,SPARC,SPP1,TAGLN,TNFSF10,VCAM1	ATF2,FOS,HIF1A,JUN,MTPN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P1	 	dimethyl sulfoxide	 	chemical drug	 	-1.676	bias	0.296	-3.198	2.36E-03	ALAS2,BMP2,BMP4,CA3,CCND2,CCND3,COL22A1,CXCL8,DDIT3,DNAJB4,EIF4EBP1,EIF4EBP2,EMP3,FECH,FOS,FRZB,HMOX1,IRS2,ITGAM,JUN,KAT2B,MYC,NUPR1,PDZD2,SPI1,SQSTM1,SRC,TFRC,VCAM1	Ap1,CTNNB1,ESR1,FOS,HDAC1,HIF1A,JUN,MYC,NFATC2,NFKB1,NFkB (complex),Nfat (family),RELA,SP1,SRC,STAT3,TCF,dimethyl sulfoxide,sirolimus	
P1	 	2-amino-3-phosphonopropionic acid	 	chemical - endogenous mammalian	 	 	 	 	 	2.44E-03	EGR1,FOS,JUNB	2-amino-3-phosphonopropionic acid,CREB1,FOS,NFkB (complex),Pkc(s),RELA,STAT3	
P1	 	CIDEB	0.372	other	 	 	 	 	 	2.44E-03	ADIPOQ,LEP,PLIN2	 	
P1	 	EMD	0.717	other	 	 	 	 	 	2.44E-03	BMP2,EGR1,IER3	 	
P1	 	ERC1	0.424	other	 	 	 	 	 	2.44E-03	CXCL8,NFKBIA,PTGS2	Ap1,ERC1,IKBKB,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P1	 	F Actin	 	complex	 	 	 	 	 	2.44E-03	CTGF,FLNA,MMP2	 	
P1	 	Fascin	 	group	 	 	 	 	 	2.44E-03	CTGF,CYR61,MMP9	Akt,CTNNB1,Fascin,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TCF,TP53	
P1	 	GFRA2	0.609	transmembrane receptor	 	 	 	 	 	2.44E-03	EGR1,EGR2,FOSB	ERK1/2,GFRA2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3	
P1	 	HIST1H1D	-0.106	other	 	 	 	 	 	2.44E-03	AXIN2,H19,MYC	 	
P1	 	MATK	0.831	kinase	 	 	 	 	 	2.44E-03	CXCR4,LYN,SRC	 	
P1	 	SB-657510	 	chemical reagent	 	 	 	 	 	2.44E-03	ATP2A2,MTOR,SLC9A1	 	
P1	 	TNKS	-0.002	enzyme	 	 	 	 	 	2.44E-03	AXIN1,MCL1,MYC	AKT1,FOXO1,HIF1A,NFKB1,NFkB (complex),PTEN,SP1,STAT1,STAT3,TNKS,TP53	
P1	 	TOR2A	0.259	other	 	 	 	 	 	2.44E-03	ACAT1,FOS,MYC	 	
P1	 	ZNF300	0.034	other	 	 	 	 	 	2.44E-03	CXCL8,IL6,MYC	ERK1/2,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,ZNF300	
P1	 	atipamezole	 	chemical drug	 	 	 	 	 	2.44E-03	EGR1,FOS,JUNB	 	
P1	 	sulprostone	 	chemical drug	 	 	 	 	 	2.44E-03	PTGS2,THRSP,VEGFC	 	
P1	 	trimethyloxamine	 	chemical - endogenous non-mammalian	 	 	 	 	 	2.44E-03	ATF4,DDIT3,IL6	 	
P1	 	RETNLB	-0.042	other	 	-0.325	bias	0.475	-2.440	2.45E-03	CCL2,CCL3L3,CCR1,CD86,COL1A1,COL1A2,CTGF,ELN,FRZB,HEY1,IRS2,MMP2,MYC,PLA2G15,SFRP1,SOCS2,STOM,THBS4,TIMP1,TINAGL1	Ap1,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,RETNLB,SP1,STAT1,STAT3,TNF	
P1	 	ascorbic acid	 	chemical - endogenous mammalian	 	0.459	 	0.047	0.260	2.45E-03	ALPL,BCL2L1,BMF,CXCL8,DDIT3,HIF1A,HSPA5,IGFBP3,IGFBP4,IL6,ISCU,ITGA1,MGP,NDRG1,PMP22,PRKCD,PTGS2,SLC20A1,SPARC,SPP1	Ap1,CREB1,Ca2+,ESR1,HIF1A,JUN,LDL,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SP1,STAT3,TP53,ascorbic acid,hydrogen peroxide,reactive oxygen species	
P1	 	NQO1	0.519	enzyme	 	-0.093	 	0.122	-0.514	2.45E-03	BCL2L1,BIRC3,C5AR1,CCR1,CSF3R,CXCL12,CXCR4,KIT,MMP9,PTGS2,SPI1,VCAM1	Akt,Ap1,HIF1A,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NQO1,RELA,SP1,STAT1,STAT3,TP53	
P1	 	amiodarone	 	chemical drug	Activated	2.111	bias	0.267	1.224	2.45E-03	AK4,CA3,CXCL8,GRN,HMOX1,LDLR,LSS,ME1,SLC2A3,SLCO2B1,TAGLN,TF	ATF2,FOXO1,Growth hormone,HIF1A,Insulin,NFkB (complex),PPARA,PPARD,PPARG,SREBF1,amiodarone,arachidonic acid,fatty acid	
P1	 	beta-carotene	 	chemical - endogenous mammalian	 	0.577	bias	-0.501	 	2.45E-03	DGAT2,ELOVL6,FADS3,HSPA1A/HSPA1B,IL6,LPGAT1,ME1,MID1IP1,NPR3,PTGS2,RBP4,THBD	JUN,LEP,NFkB (complex),PPARG,RNA polymerase II,STAT3,beta-carotene	
P1	 	propofol	 	chemical drug	 	-0.464	bias	-0.334	0.622	2.45E-03	BCL2L1,CCL2,CD14,EGR1,FOS,HMOX1,IL6,MMP2,MMP9,NET1,THBS1,ZFP36	Akt,Ap1,D-glucose,ERK,HIF1A,JUN,Jnk,MYC,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SMAD3,STAT3,TP53,propofol	
P1	 	RUNX1	0.808	transcription regulator	 	0.836	 	0.218	-0.119	2.47E-03	ADGRG1,ALCAM,BCL2L12,BTG2,CCND3,CD4,CDKN2B,CPA3,CSF1R,CSF2RA,CTSG,CYB561,CYP11A1,FSCN1,GPAM,IGF2R,IGFBP3,MECOM,NR4A3,PCDH7,RGCC,S100A9,SH3GL1,SLC24A3,SPI1,SPP1,TIMP1,TJP1,TPSAB1/TPSB2,UPP1	Ap1,CBFB,CEBPA,ESR1,FOS,HDAC1,Histone h3,IRF8,JUN,MYC,NFkB (complex),PPARG,RELA,RNA polymerase II,RUNX1,SP1,SPI1,STAT3,TP53	
P1	 	IND S7	 	chemical - kinase inhibitor	 	-0.632	 	-0.179	-0.066	2.49E-03	ATP5D,C1QBP,COPS8,ENO1,ERP29,GLOD4,HSPA1A/HSPA1B,PCK2,STIP1,TUBB	 	
P1	 	PLIN5	-0.350	other	Activated	2.530	 	-0.036	2.643	2.49E-03	ACADM,ACADVL,ACSM5,ATF4,GSS,HMOX1,NQO1,PDK4,POR,TXNRD1	 	
P1	 	crocidolite asbestos	 	chemical toxicant	 	-0.531	bias	0.501	 	2.49E-03	FOS,GADD45A,GCLM,JUN,JUNB,MAPK7,MYC,PRKCD,SPP1,SRC	ATF2,Ap1,EGFR,ERK1/2,ESR1,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,SRC,STAT3,crocidolite asbestos	
P1	 	methamphetamine	 	chemical drug	 	-0.807	 	0.183	-1.517	2.55E-03	ABCC1,BCL2L1,CAST,EGR1,FOS,FOSB,HMOX1,HOMER2,IL6,JUN,MAOA,MMP2,MMP9,MYC,NAT8L,PCLO,SIGMAR1,TXN,VCAM1	Ap1,ELK1,ERK,ERK1/2,ESR1,FOS,IL6,JUN,MAPK3,NFATC2,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,STAT1,STAT3,methamphetamine	
P1	 	FGFR1	0.144	kinase	 	-0.775	bias	0.251	-1.864	2.58E-03	BMP4,CCND2,COL1A1,DNAJC1,DUS2,EIF3C,EIF4EBP1,EIF4EBP2,FGF2,FOS,GRINA,IL6,JUN,MBP,MYC,NOTCH1,PDCD4,PLAUR,PLXNB2,PTGS2,PTPRA,SPARC	Ap1,ELK1,ERK1/2,FGF2,FGFR1,FOS,JUN,MAPK3,MAPK8,NFKB1,NFKB2,NFKBIA,NFkB (complex),PRKCD,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	9,10-dimethyl-1,2-benzanthracene	 	chemical toxicant	 	-0.010	bias	0.446	-1.395	2.63E-03	BCL2L1,CCDC80,CYP1B1,EPHX1,GADD45A,HBEGF,HRAS,IL6,JUN,MMP9,NQO1,PTGS2,RUNX1	9,10-dimethyl-1,2-benzanthracene,Ap1,CREB1,Ca2+,ESR1,IRF8,JUN,Jnk,MYC,NFATC2,NFKBIA,NFkB (complex),Nfat (family),RELA,SP1,STAT1,STAT3,TP53,TP73	
P1	 	NCOR2	0.403	transcription regulator	 	-0.243	 	-0.215	0.279	2.63E-03	ADIPOQ,AXIN2,BIRC3,CD69,CXCL8,FOS,IL6,JUN,PLA2G2A,PLIN1,POMC,PTGS2,RARA	Ap1,ESR1,FOXO1,GTF2I,HDAC3,JUN,NCOR2,NFATC2,NFE2L2,NFKBIA,NFkB (complex),Nfat (family),PLA2G2A,PPARA,PPARG,PPARGC1A,RELA,RXRA,SNAI1,STAT3,THRB	
P1	 	chloropromazine	 	chemical drug	 	0.885	 	0.193	0.319	2.63E-03	ACAT2,DHCR7,FOS,HMGCS1,LDLR,LSS,MSMO1,NR4A2,NR4A3,SERPINA3,SLC2A3,SQLE,TAGLN	ADRA1B,CREB1,FOS,NFkB (complex),Pkc(s),RELA,STAT3,chloropromazine	
P1	 	5'-methylthioadenosine	 	chemical - endogenous mammalian	 	0.000	 	-0.046	0.112	2.64E-03	ADIPOQ,COL1A1,COL1A2,FGF2,GUCY1A3,PTGS2	5'-methylthioadenosine,Ap1,CEBPA,CEBPB,ESR1,Histone h3,IRF8,JUN,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53	
P1	 	BTC	-0.135	growth factor	 	-0.816	bias	0.418	-1.840	2.64E-03	CXCL8,IL6,IRS2,ITGAM,MMP9,PTGS2	AKT1,Akt,Ap1,BTC,EGF,ERK1/2,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	CHRM1	-0.006	g-protein coupled receptor	Inhibited	-2.423	bias	0.251	-3.030	2.64E-03	CYR61,EGR1,EGR2,EGR3,FOS,JUN	CEBPB,CHRM1,CREB1,Ca2+,ELK1,FOS,JUN,MAPK1,MKL1,MKL2,NFkB (complex),Pkc(s),RELA,SP1,SRF,STAT1,STAT3,TP53,cyclic AMP	
P1	 	L-histidine	 	chemical - endogenous mammalian	 	0.637	bias	-0.334	1.433	2.64E-03	ASNS,ATF3,ATF4,DDIT4,EGR1,PPP1R15A	ATF3,ATF4,Ap1,CREBBP,DDIT3,EGR1,ESR1,FOXO1,Growth hormone,HIF1A,Insulin,L-histidine,NFE2L2,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,SMAD3,SMARCA4,SP1,STAT3,TP53	
P1	 	buthionine sulfoximine	 	chemical drug	 	-1.664	bias	0.251	-2.274	2.64E-03	BCL2L1,CXCR4,FOS,HBEGF,HMOX1,PTGS2	Akt,Ap1,HIF1A,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,RELA,Ras,SP1,STAT1,STAT3,TP53,buthionine sulfoximine	
P1	 	methylselenic acid	 	chemical reagent	Activated	2.157	 	-0.134	2.532	2.67E-03	ABCA5,ACSL3,ADAMTS1,ALDH3A2,ARID4A,ATF3,ATF5,BIRC3,BMP4,CDC20,CDK4,CDKN1C,CHEK2,DDIT3,DHCR24,DUSP10,EPHX1,ERCC1,ESR1,G3BP2,GADD45A,GDF15,GUCY1A3,H1F0,HSD17B11,ID1,ID3,ING1,JUN,JUNB,KLF4,MAP1B,MAP2K3,MAP2K5,MATN2,MCL1,MCM2,MYC,NDRG1,NEDD4L,NQO1,NREP,RHOB,SGK1,STX1A,TAF6,TGFBR3,TNFAIP3,VEGFC,ZNF75D	Akt,CEBPA,E2F1,ERK1/2,ESR1,ESR2,HIF1A,JUN,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TP53,beta-estradiol,methylselenic acid,reactive oxygen species	
P1	 	metribolone	 	chemical reagent	 	1.012	bias	0.283	-0.721	2.73E-03	ACACA,ACLY,ACSL3,ACTN1,ADAMTS1,ADRM1,AKAP12,BCL2L1,CDKN2B,CXCR4,CYB561,DHCR24,EGR1,EIF5,FOS,GDF15,GFPT1,HES6,HOMER2,IL6,LDLR,MAF,MAOA,MARS,MMP2,NDRG1,NEDD4L,PMEPA1,PRKCD,RAD23A,S100P,SCAP,SORD,STK39,TACC2,THBS1,TM4SF1,TSC2,TSC22D1,UNC13B,VCAN	AKT1,AR,Akt,CREBBP,CTNNB1,EP300,HIF1A,JUN,MYC,NCOR1,NFKB1,NFkB (complex),NR3C1,RELA,SP1,STAT1,STAT3,TP53,dihydrotestosterone,metribolone	
P1	 	ADRA1D	0.016	g-protein coupled receptor	 	 	 	 	 	2.73E-03	ADRA1B,APBA3,CEBPD,COL3A1,DUSP1,EGR1,EGR2,FOS,IL6,JUN,LOX,NFIX,NR4A2,POLA2	ADRA1D,Ap1,CEBPA,CEBPB,CREBBP,EP300,ERK1/2,FOS,GATA4,JUN,MAPK8,MEF2C,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53,phenylephrine,prazosin	
P1	 	PPARGC1A	-0.238	transcription regulator	 	0.778	bias	0.401	-1.722	2.74E-03	ACACA,ACADM,ACADVL,ACAT1,ADGRG1,ADIPOQ,AK1,BCAT2,CAT,CD36,CD68,CEBPD,CIDEA,COMP,CS,CYP11A1,ERBB2,FNDC5,GOT2,GSK3B,HMGCL,IL6,IRS2,ITGB1BP1,LDLR,LPIN1,MBP,ME1,MYH1,NDUFS8,NR5A2,PCK2,PDK4,PLIN2,PRDX5,PTGS2,RBP4,SESN2,SOCS3,TNFRSF12A,TRIB3,TXNRD2,UCP2,UQCRH	Ap1,CEBPA,FOXO1,Growth hormone,HIF1A,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SREBF1,fatty acid,palmitic acid	
P1	 	hexachlorobenzene	 	chemical toxicant	Activated	2.546	bias	0.431	0.831	2.76E-03	ASNS,CD14,EFEMP2,EMP3,GPNMB,IER3,LXN,MMP2,MMP9,MYC,PSMB10,RCN1,SPP1,TIMP1,TNFRSF12A,UPP1	ATF2,CTNNB1,EGFR,ERK1/2,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,SP1,SRC,STAT3,hexachlorobenzene	
P1	 	DCN	-0.148	other	Inhibited	-2.113	 	-0.042	-1.954	2.77E-03	CDKN1C,COL1A2,CTGF,DUSP1,ERBB2,FGF2,FST,HIF1A,IL6,KIT,MMP2,MMP9,S1PR1,THBS1,VCAM1	Akt,Ap1,DCN,HIF1A,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD1,SMAD3,SMAD4,SP1,STAT1,STAT3,Smad,TGFBR2,TP53,Tgf beta	
P1	 	enalapril	 	chemical drug	 	0.641	 	0.029	0.527	2.77E-03	ADAMTS1,AGT,ASNS,CAPN6,EFEMP2,GSTM3,IER3,KDR,MYC,SPP1,TGFBR2,TIMP1,TNFRSF12A,UCP2,VCAM1	HGF,JUN,NFKB1,NFkB (complex),SMAD3,SMAD4,SP1,STAT3,TGFB1,enalapril	
P1	 	COL4A3	0.020	other	 	 	 	 	 	2.78E-03	COL1A1,COL1A2,COL3A1,COL4A5,CTGF,MMP2,MMP9,PTGS2,TIMP1	Ap1,COL4A3,CTNNB1,ETS1,ITGB3,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD4,STAT3,TP53,VEGFA	
P1	 	arotinoid acid	 	chemical toxicant	 	1.206	bias	0.283	0.376	2.78E-03	DUSP1,FOLR2,FOS,ODC1,PLA2G15,PLTP,RARA,RARRES1,SOX9	ATF2,Ap1,CEBPB,CREB1,Ca2+,EGF,EGFR,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RARB,RELA,SMAD3,SP1,STAT1,STAT3,TNF,TP53,arotinoid acid	
P1	 	methyl-beta-cyclodextrin	 	chemical drug	 	1.195	 	0.000	1.195	2.78E-03	BCL2L1,CAV1,CXCL8,HIF1A,IL6,LDLR,MYC,PLA2G2A,ZFP42	CEBPB,ERK,ERK1/2,JUN,MAP2K1,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SMAD3,SP1,SRC,STAT1,STAT3,methyl-beta-cyclodextrin	
P1	 	etoposide	 	chemical drug	 	-0.443	 	0.242	-1.797	2.78E-03	ABCG1,ADAM17,ATF3,BCL2L1,BIN1,BIRC3,CCL3,CD86,CHCHD6,COL1A2,CTSD,CXCL8,DDIT4,DUSP1,FTH1,GADD45A,GDF15,HK1,IER3,IFIT2,JUN,MCL1,MME,PEBP1,PFKL,PIDD1,RNF144B,SGK1,SLC2A3,SQSTM1,TAF6,TNFAIP3,TNFRSF10B,TNFSF10	Ap1,HIF1A,JUN,Jnk,MAX,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,etoposide	
P1	 	aspirin	 	chemical drug	 	1.270	 	-0.242	2.321	2.81E-03	ABCG1,ADRB2,BCL2L1,CCL2,CCL3,CD86,CXCL8,CXCR4,CYB5A,DDIT3,GDF15,IDO1,IL6,MCL1,MMP2,MMP9,NOX4,PLA2G4A,PTGS2,SOX7,TNFSF10,TYMP,VCAM1	Ap1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,aspirin,prostaglandin E2	
P1	 	pyrrolidine dithiocarbamate	 	chemical reagent	 	1.390	bias	-0.351	3.097	2.82E-03	ASS1,BCL2L1,BIRC3,BMF,BMP2,CCL2,COL1A1,CTGF,CXCL2,CXCL8,CXCR4,GCLM,HIF1A,HMOX1,IDO1,IL6,MAFG,MMP2,MMP9,MYC,NFKBIA,PTGS2,SELE,SOX9,VCAM1	Akt,Ap1,HIF1A,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT3,TP53,pyrrolidine dithiocarbamate	
P1	 	TERC	0.013	other	 	 	 	 	 	2.88E-03	ALAD,CDC20,CLEC4F,CYP2C8,EGR1,H19,H1F0,NR1D1,S100A9,THRA,TUBB2A	 	
P1	 	tempol	 	chemical drug	 	-0.213	bias	-0.251	0.608	2.88E-03	BCL2L1,BMP4,CAT,CXCL2,CXCL8,MMP9,PTGS2,SGK1,SPP1,UCP2,VCAM1	AMPK,Akt,Ap1,ELK1,FOS,FOXO1,HIF1A,JUN,MAPK3,NFKBIA,NFkB (complex),PI3K (complex),PPARGC1A,RELA,SP1,STAT1,STAT3,TP53,nitric oxide,tempol	
P1	 	Histone h3	 	group	 	 	 	 	 	2.89E-03	ACOT4,ACTA1,ADGRA2,ADIPOQ,ADRA1A,ADRA1B,AKAP12,BMP4,BTG3,CA4,CAV1,CCL2,CCND2,CD69,CDK4,CDKN2B,CDKN2C,CHFR,CKAP4,COL1A2,CSF1R,CSPG4,CXCL8,DUSP10,EGR1,EPHB3,ESR1,FOS,G6PD,GAPDH,HOXA9,ID1,IGF2R,IGFBP3,IGFBP4,IL6,JUN,KDR,KLF2,MCM2,MGMT,MKX,MMP9,MT1G,MTUS1,NFKBIA,OSGIN1,PTGS2,RAB38,RARA,RCAN1,RELN,SATB2,SBF1,SFRP1,SGK1,SNUPN,SOCS3,SOX17,SPATS2L,SPP1,STOM,TACC2,TAGLN,TGFBR2,TNFAIP3,TNFSF10,TRIB1,UPP1,UQCRC1,VKORC1,ZNF239	Ap1,EGR1,ESR1,ESR2,HIF1A,Histone h3,IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	FGFR2	0.036	kinase	 	1.745	 	0.146	1.083	2.90E-03	BMP4,BMPER,CA4,CCND2,COL1A1,CTSH,CUBN,DAB2,FST,HRAS,IL6,INHBB,KBTBD11,MBP,NNAT,NOTCH1,NR5A2,PCOLCE,PLAUR,PLXNB2,PTPRA,SFRP1,SOX17,SOX7,SPP1,TENM3,VCAM1,VEGFC	Akt,Ap1,ERK1/2,ESR1,FGFR2,HIF1A,Histone h3,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TNF,TP53,thalidomide	
P1	 	NFKB1	0.061	transcription regulator	 	-1.063	bias	0.349	-2.913	2.95E-03	ADORA1,AKR1B1,APOE,BAMBI,BCL2L1,BIRC3,BMP2,BTG2,CCL2,CCL3L3,CCND2,CD59,CD86,CFB,COL1A1,COL1A2,CSF2RA,CTSB,CXCL2,CXCL8,DUSP1,EGR1,ENPP2,FCGRT,FOS,FSCN1,GBP1,GRK5,HMOX1,IER3,IGFBP3,IKBKG,IL6,MAP3K8,MCL1,MMP9,MYC,NFKBIA,PTGS2,PTX3,SDC4,SELE,SOX9,STIM1,TNFAIP3,TNFRSF4,TNFSF10,VCAM1	Ap1,HIF1A,IKBKB,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	11,12-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.332	 	0.201	-1.885	2.97E-03	ADIPOQ,DUSP1,MMP9,NFKBIA,NME1,PLAT,SELE,VCAM1	11,12-epoxyeicosatrienoic acid,ATF4,Ap1,E2F1,EGR1,FOXO1,Growth hormone,HIF1A,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SREBF1,STAT3	
P1	 	CYP2E1	0.358	enzyme	 	0.339	bias	0.343	-0.606	2.97E-03	C5AR1,CAT,CD14,COL1A2,HMOX1,IL6,NCF2,PTGS2	Ap1,CYP2E1,EP300,JUN,NADPH oxidase,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,acetaminophen,carbon tetrachloride,ethanol	
P1	 	K-252	 	chemical - kinase inhibitor	 	1.463	bias	-0.401	2.591	2.97E-03	CD14,CXCL8,ITGAM,JUN,MYCN,NDRG1,PPP1R1B,SPP1	Akt,ERK,ERK1/2,HDAC1,HIF1A,Hdac,JUN,K-252,NFATC3,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,prostaglandin E2	
P1	 	carvedilol	 	chemical drug	 	1.230	bias	-0.368	2.186	2.97E-03	ATP2A2,CYBA,GAP43,HMOX1,IL6,MMP2,MYC,NPR3	APP,ARRB2,Ap1,ERK,FOXO1,HIF1A,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,TP53,carvedilol,palmitic acid	
P1	 	salvin	 	chemical toxicant	 	1.321	 	0.100	1.043	2.97E-03	CCL2,CD14,CES1,CXCL8,EGR1,IL6,ITGAM,MMP9	ATF2,Ap1,EGFR,ERK1/2,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,salvin	
P1	 	CGB3 (includes others)	0.096	other	 	1.103	bias	0.301	0.319	2.98E-03	CYP11A1,LHCGR,MMP2,PTGS2,RUNX1,SGK1,WNT5B	AR,CEBPB,CGB3 (includes others),CREB1,Creb,ERK1/2,ESR1,FOS,FSH,JUN,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,cyclic AMP,testosterone	
P1	 	D609	 	chemical reagent	 	-0.059	 	-0.167	0.344	2.98E-03	CCL2,CXCL8,IL6,JUN,MMP9,PTGS2,VCAM1	Akt,Ap1,D609,ERK1/2,ESR1,HIF1A,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PRKCE,RELA,SMAD3,STAT1,STAT3,TNFRSF1A,TP53	
P1	 	DIRAS3	0.127	enzyme	 	-1.134	bias	0.376	-2.129	2.98E-03	CAPN6,DNASE1L3,FOSB,HMGA1,MT1G,MT1L,TFPI2	 	
P1	 	IKK (complex)	 	complex	 	-0.378	 	-0.100	-0.113	2.98E-03	BCL2L1,BIRC3,CXCL8,MMP9,MYC,PTGS2,VCAM1	Ap1,HDAC3,HIF1A,IKBKB,IKK (complex),JUN,NCOR2,NFE2L2,NFKB1,NFKB2,NFKBIA,NFkB (complex),PPARG,RELA,SNAI1,STAT3,TP53,curcumin	
P1	 	MAFG	0.513	transcription regulator	 	0.728	bias	0.270	0.138	2.98E-03	ABCC3,GCLM,HMBS,HMOX1,MAFG,NQO1,TXNRD1	 	
P1	 	NCAM1	-0.170	other	 	-0.570	bias	0.376	-1.556	2.98E-03	BCL2L12,GLUL,HSPA4,NFKBIA,NLGN1,THBS1,THY1	 	
P1	 	diethylmaleate	 	chemical toxicant	Activated	2.583	 	0.063	2.421	2.98E-03	HMOX1,MAFG,NFKBIA,NQO1,SELE,SLC3A2,TNFAIP3	BACH1,HIF1A,JUN,NFE2L2,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT3,TP53,diethylmaleate	
P1	 	silicon dioxide	 	chemical drug	 	-1.890	bias	0.313	-2.719	2.98E-03	CCL2,CST3,CXCL8,FOS,JUN,JUNB,SFTPD	Ap1,CREB1,ERK,ESR1,FOS,JUN,MAPK9,NFATC2,NFkB (complex),Nfat (family),Pkc(s),RELA,SMAD3,SP1,STAT3,silicon dioxide	
P1	 	superoxide	 	chemical - endogenous mammalian	Activated	2.186	bias	0.424	1.259	2.98E-03	CAV1,CYBA,HMOX1,ID3,MMP9,PTGS2,TIMP1	Ap1,EP300,ERK1/2,ESR1,JUN,NADPH oxidase,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,Ras,SMAD3,SP1,STAT1,STAT3,superoxide	
P1	 	C5	0.404	cytokine	 	-1.538	 	0.222	-2.641	2.99E-03	ATF3,C5AR1,CCL13,CCL2,CCL3,CCL3L3,CD55,CD59,CXCL2,CXCL8,EFNB2,EGR1,GDF15,IL6,ITGAM,NFIX,NFKBIA,PLAT,PPP1R15A,SELE,SLC25A15,SMAD7,TNFAIP3,VCAM1,VEGFC,ZFP36	C5,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,prostaglandin E2	
P1	 	IKZF1	-0.206	transcription regulator	 	-1.181	 	-0.190	-0.211	3.02E-03	AJUBA,ALAS2,AXL,BCL2L1,C1QTNF1,CCND2,CCND3,DOCK1,EBF1,EMP1,EPB42,KIAA1211L,KIT,LHFPL2,LYN,MYC,NFIX,NOTCH1,POMC,PRNP,PRRT3,RUNX1,SELM,SERPINH1,SLC19A1,SPI1,SULF2,TMEM119,ZFPM1	IKZF1,IL2,NFKB1,NFKBIA,NFkB (complex),NR3C1,STAT1	
P1	 	IRF8	-0.022	transcription regulator	 	0.044	bias	0.271	-1.275	3.02E-03	ATF3,BCL2L1,CD14,CD4,CD86,CFB,CSF1R,CSF3R,CXCL16,DAB2,EGR1,EGR2,ETV6,FOS,GBP1,ID3,IDO1,IFIT2,IL6,ITGAM,KLF4,KLF6,LSP1,MAF,MAP4K4,MMP9,MYC,PCDH7,TYROBP	IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT,STAT1,STAT3,TNF	
P1	 	GW501516	 	chemical drug	 	-0.789	bias	0.368	-2.094	3.03E-03	ACADM,ACSL4,ADIPOQ,ANGPTL4,CAT,COL5A1,COL6A1,GZMH,HADHA,IGFBP3,IGFBP6,LIPE,LIPG,LPIN1,NOTCH1,PDK4,PLAT,PLIN2,S100A8,S100A9,SAA1,SLC27A1,THBS1,UCP2	ATF6,Ap1,CEBPA,CEBPB,FOS,FOXO1,GW501516,Ins1,JUN,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SIRT1,SREBF1,STAT1,STAT3,TP53,oleic acid	
P1	 	ATN1	0.786	transcription regulator	 	 	 	 	 	3.13E-03	ADRBK1,ASGR1,BTG3,CA4,DBP,DLG4,EBF1,GRK5,HBEGF,HIST2H2AA3/HIST2H2AA4,IL11RA,KAT2A,KCNK3,LTBP2,MCAM,NREP,PDE1B,PPP1CB,PPP2R1A,PRKCD,PTPRF,RGS16,SOCS2,SPP1,THRA,THRSP,TM4SF1,TUBB,TYRO3,VAMP1	 	
P1	 	ENG	0.131	transmembrane receptor	 	-0.263	 	0.118	-0.630	3.15E-03	CDH5,CTGF,CXCR4,ELN,ID1,ITGA1,KDR,MYC,SMAD6,SMAD7,TGFBR2,THBS1	ACVRL1,ENG,GATA4,NFkB (complex),NOTCH1,RUNX2,SMAD1,SMAD3,SMAD4,SMAD5,SMAD7,SP1,STAT3,Smad,TGFB1,TGFBR2	
P1	 	Hsp27	 	group	 	-1.397	 	0.049	-1.562	3.15E-03	CD14,CD163,CD86,CSF1R,CXCL8,FOS,GBA,IL6,NOX4,PLA2G2A,PPP1R1B,PTGS2	Akt,Ap1,CREBBP,HIF1A,Hsp27,IL10,IL6,JUN,MAP2K6,MEF2C,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,SRF,STAT1,STAT3,TP53	
P1	 	propranolol	 	chemical drug	 	0.194	 	-0.106	0.490	3.15E-03	ADIPOQ,ATP2A2,AXIN1,DUSP1,FOS,IL6,LEP,LEPR,MAOA,MYC,NFKBIA,PTGS2	AR,CREBBP,CTNNB1,Creb,EP300,ERK1/2,ESR1,IL6,JUN,LEP,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,TP53,propranolol,testosterone	
P1	 	SPIB	-0.010	transcription regulator	 	0.799	bias	0.404	-1.037	3.19E-03	APOE,ATF3,BMP6,BTK,CD209,CD86,CLEC10A,CLEC4G,EGR1,EGR2,GNA15,HSPA1A/HSPA1B,KDR,KIT,KLF6,MBD2,NET1,NRXN2,PTPRF,SLC22A12,TENM4	 	
P1	 	BCL2	-0.380	transporter	 	1.616	 	0.202	0.635	3.23E-03	ABCC1,ATP2A2,BCL2L1,CLCN3,CTSH,CXCL8,FOS,GADD45A,GAP43,HAVCR2,HIF1A,IGFBP6,IL6,MCAM,MCL1,MMP2,MMP9,NDRG1,NFKBIA,NNAT,PCDHA1,PLAUR,SOX9,SQSTM1,TIMP1	Akt,Ap1,BCL2,ERK,ERK1/2,HIF1A,IKBKB,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TP53	
P1	 	phenethyl isothiocyanate	 	chemical drug	 	0.053	 	-0.137	0.434	3.23E-03	BCL2L1,C21orf33/LOC102724023,CAPN2,ERBB2,ESR1,GCLM,GSS,H2AFZ,IDH1,IFIT2,KAT2B,KDR,LARS,MAP2K3,MCL1,MMP2,NNMT,PLS3,PTPRE,QSOX1,TMED2,TTC1,TXN,TXNL1,TXNRD1	ATF2,Akt,Ap1,CEBPA,CEBPB,EGF,EGFR,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,SMAD3,SP1,STAT1,STAT3,TP53,phenethyl isothiocyanate	
P1	 	isobutylmethylxanthine	 	chemical toxicant	 	0.021	bias	0.253	-1.262	3.23E-03	ACSL3,ACSL4,ADIPOQ,AEBP1,AGT,ALDH3B1,ANGPTL4,CAV1,CD14,CD36,CEBPD,CRABP2,CRHBP,CXCR4,CYP11A1,DHRS3,EGR1,FOS,GAPDH,JUN,JUNB,MMP2,MYC,NOTCH1,PDE3B,PLAT,PLIN1,PLIN2,TIMP1,TUBB,TYRO3	CEBPA,CEBPB,CREBBP,CTNNB1,Creb,EP300,FOS,FOXO1,HDAC1,Ins1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TNF,TP53,isobutylmethylxanthine	
P1	 	SOX4	-0.034	transcription regulator	 	1.102	bias	0.309	-0.770	3.26E-03	AES,ALDH1B1,CACNA1H,CAPN2,CDH2,CHAC1,DDAH2,EMP1,FCER1G,FHL1,FOS,GCAT,GPR183,HIPK2,IGFBP4,KANK1,KIAA0922,LRRN3,LYZ,MAP7,MBP,NAV1,NREP,NRXN2,RARRES1,RNASE4,RNF144A,SERPINE2,SLC2A6,SNX10,SPI1,TAX1BP3,TENM4,TMEM98,TNFRSF19,TSPAN6,TUBB2B,UCHL1	 	
P1	 	gentamicin C	 	chemical drug	 	1.265	bias	0.438	-0.535	3.26E-03	ADAMTS1,ASNS,BIRC3,CAPN6,CD14,EFEMP2,EMP3,GPNMB,IER3,LXN,MYC,PSMB10,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	2-methoxyestradiol	 	chemical - endogenous mammalian	 	-0.628	 	0.075	-0.882	3.31E-03	ATF3,BCL2L1,CAV1,CXCR4,HIF1A,ID1,IL6,LOC102724788/PRODH,LOX,MCL1,PTGS2,SERPINE2,SPON1	2-methoxyestradiol,ARNT,Ap1,CAT,ETS1,HIF1A,IL6,JUN,MYC,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT3,TP53,VEGFA,VHL	
P1	 	GPX1	-0.181	enzyme	 	0.799	bias	-0.358	1.975	3.31E-03	CAT,CCL3L3,CD14,CTGF,FAF1,GLRX,GLRX2,GPX3,IL6,MMP9,TNFSF10,TXN,VCAM1	Ap1,ESR2,FOS,GPX1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,reactive oxygen species	
P1	 	NFATC2	0.097	transcription regulator	 	-1.095	bias	0.325	-2.781	3.31E-03	ACP5,CCL3L3,CDK4,DAB2,EDN1,EGR2,EGR3,ENPP2,FCER2,GBP4,IFIT2,ISG20,LMO4,MAF,MYC,NFKBIZ,NOX4,PDZD2,PELI1,PLA2G2A,PLAT,PTGS2,PTPRK,RCAN1,RGS1,RILPL1,SELE,SLC3A2,SOCS2,SOCS3,SRC,TSC22D1	IFNG,IL10,IL2,IL6,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT1,STAT3,TNF	
P1	 	NME1	1.293	kinase	 	0.399	 	-0.181	0.935	3.31E-03	BOP1,CDK4,CTGF,CTSD,FBL,LPAR1,METTL1,MMP2,PA2G4,RAE1,SMAD7,SMO,TIMP1	Ap1,JUN,Jnk,NFkB (complex),NME1,PI3K (complex),RELA,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TGFBR1	
P1	 	ciprofibrate	 	chemical drug	 	-1.260	 	-0.021	-1.146	3.31E-03	ACADM,ADAMTS1,AKR1C4,APOB,BSG,CAT,CCND2,CD36,CIDEA,CRAT,CSTB,CXCL12,CYP27A1,CYP2C8,ELOVL3,ETS2,GOT1,HADHA,KRT8,LHPP,MYH1,NFKBIA,PALMD,PDK4,PHLDA1,PLIN2,QPCT,RGN,SLCO2A1,SLCO2B1,SQSTM1,VEGFD	ACOX1,ATF6,Ap1,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,RXRA,SREBF1,STAT3,TNF,ciprofibrate,oleic acid	
P1	 	methyl methanesulfonate	 	chemical toxicant	 	-0.815	bias	0.476	-2.492	3.31E-03	ATF3,BTG1,BTG2,CTSD,DDIT3,EGR1,GADD45A,GADD45B,JUN,KLF4,MCL1,PHLDA3,PLXNB2	ATF2,Ap1,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,TP73,methyl methanesulfonate	
P1	 	3-methyladenine	 	chemical toxicant	Inhibited	-2.093	 	0.000	-2.093	3.35E-03	ADIPOQ,CD86,CXCL2,CXCL8,HMOX1,HSPA5,IL6,PTGS2,RCAN1,SQSTM1	3-methyladenine,AMPK,Ap1,CREB1,Ca2+,FOXO1,IL6,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PPARGC1A,RELA,SP1,STAT1,STAT3,TP53	
P1	 	S100A6	0.099	transporter	Activated	2.538	 	0.000	2.538	3.35E-03	ADAMTS1,ATF3,CXCL2,CXCL8,DHRS9,PRNP,RDH5,SELE,STC1,TNFAIP3	CREB1,Ca2+,NFkB (complex),S100A6,SP1,STAT3,TP53	
P1	 	betulinic acid	 	chemical drug	 	-0.070	bias	-0.270	0.721	3.35E-03	BCL2L1,CXCL12,CYBA,IL6,MMP2,MMP9,NOX4,PTGS2,TIMP1,TNFRSF10B	AMPK,Akt,CEBPA,CEBPB,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARGC1A,RELA,STAT1,STAT3,TP53,betulinic acid	
P1	 	nicotinic acid	 	chemical - endogenous mammalian	 	1.201	 	-0.017	1.255	3.35E-03	ABCG1,ADIPOQ,ANGPT1,CD36,ELOVL6,G6PD,GAPDH,IL6,LIPE,TECR	Ap1,CAT,CEBPA,CEBPB,EP300,FOS,HMOX1,Ins1,LDL,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,STAT3,TP53,docosahexaenoic acid,nicotinic acid	
P1	 	N-Ac-Leu-Leu-norleucinal	 	chemical - protease inhibitor	 	1.339	 	0.206	0.436	3.38E-03	APOB,ATF4,ATF6,BCL2L1,CAV1,CCL2,CCL3,CXCL8,DDIT3,IER3,ITPR2,LAMP2,MYCN,NEDD9,NFKBIA,PAWR,PRKCE,PTGS2,PTTG1,TGFBR2	Ap1,CEBPA,CEBPB,HIF1A,JUN,Jnk,MYC,N-Ac-Leu-Leu-norleucinal,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT3,TP53,TP73	
P1	 	PRDM5	0.116	transcription regulator	 	 	 	 	 	3.38E-03	C15orf59,DKK3,EBF1,EDNRA,ETS2,GADD45B,GPR1,ISLR,LOC102724428/SIK1,MYC,MYOM2,NCOA7,NOTCH1,NREP,RARA,RUNX1,SOCS3,TINAGL1,UBL7,ZFPM1	 	
P1	 	budesonide	 	chemical drug	 	0.257	 	0.089	-0.131	3.38E-03	BTG3,CCL3L3,CEBPG,CXCL2,CXCL8,FYN,GNA11,GNAI1,HIF1A,IL6,ING1,ITGAM,JUN,MAF,MAFG,MAP2K3,PDCD6,RAE1,RAP1GAP,RGS5	CCL5,CEBPB,CREB1,EP300,IL17A,IL5,IL6,JUN,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT1,STAT3,STAT5A,STAT5B,STAT5a/b,budesonide	
P1	 	ciglitazone	 	chemical drug	 	-0.579	 	-0.092	-0.189	3.38E-03	ABCG1,AGT,APOE,CAT,CAV1,CCL2,CD36,CXCL8,ESR1,IL6,JUN,MMP2,MMP9,NFKBIA,NOX4,PTGS2,SELE,SLC9A1,TNFSF10,VCAM1	APOE,Ap1,CTNNB1,ERK1/2,FOXO1,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SMAD3,SP1,STAT3,ciglitazone	
P1	 	FOXC2	-0.392	transcription regulator	 	-0.063	bias	0.301	-1.118	3.38E-03	ADIPOQ,ADRB2,CDH2,CXCR4,EFNB2,IRS2,KDR,LIPE,MESP1,MMP2,MMP9,NOTCH1,PLIN1,PTGS2	Akt,ERK1/2,FOXC2,FOXO1,HIF1A,JUN,MTOR,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SMAD3,STAT1,STAT3,TP53	
P1	 	chromium	 	chemical drug	Inhibited	-2.182	bias	-0.388	-0.684	3.39E-03	ABHD4,AJUBA,ALDH3A1,ARHGDIA,CXCL8,CYB5A,DOK5,ESR1,G6PD,NQO1,PGD,SLC1A4,TAF6,UBL7,ZMAT3	 	
P1	 	4-(2-aminoethyl)benzenesulfonylfluoride	 	chemical - protease inhibitor	 	-0.850	 	-0.056	-0.730	3.46E-03	CXCL8,DDIT3,HMOX1,HSPA5,TNFRSF14	4-(2-aminoethyl)benzenesulfonylfluoride,APP,ARNT,Ap1,HIF1A,JUN,Jnk,MYC,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,STAT1,STAT3,VHL	
P1	 	Agtr1b	 	g-protein coupled receptor	 	-0.686	 	0.000	-0.686	3.46E-03	AGT,CTGF,FOS,PTGS2,VCAM1	Agtr1b,Ap1,ELK1,ERK,GNAQ,HIF1A,JUN,NFATC3,NFKB1,NFKBIA,NFkB (complex),PRKCE,RELA,SMAD3,SP1,SRC,SRF,STAT1,STAT3	
P1	 	CD160	0.036	transmembrane receptor	 	-1.000	 	0.215	-1.430	3.46E-03	BCL2L1,FOS,IL6,JUN,MCL1	CD160,IL6,NFkB (complex),RELA,SP1,STAT1,STAT3	
P1	 	Ccl6	 	cytokine	 	0.692	bias	0.390	-0.167	3.46E-03	CCL3L3,CTSK,MMP2,MMP9,TIMP4	 	
P1	 	Ck2	 	complex	 	-0.200	 	0.056	-0.323	3.46E-03	ATF4,BCL2L1,FOS,MYC,ZFP36	CREB1,CTNNB1,Ck2,ELK1,EP300,FOS,HIF1A,JAK2,JUN,MAX,MYC,NFKBIA,NFkB (complex),NOTCH1,PPP1R1B,PRKCB,RELA,SMAD7,SP1,STAT1,STAT3,STAT5a/b,TP53,YY1	
P1	 	DGCR8	0.419	enzyme	 	-0.651	bias	0.279	-1.268	3.46E-03	CNN1,FOS,MYC,SPI1,TAGLN	Akt,Ap1,DGCR8,ERK1/2,HDAC1,HIF1A,IRF8,JUN,NFKBIA,NFkB (complex),RELA,SMAD3,SPI1,STAT3,TP53	
P1	 	DKK3	-0.605	cytokine	 	 	 	 	 	3.46E-03	ANGPT1,ATF6,CDKN2B,MYH11,TAGLN	DKK3,MYOCD,SRF	
P1	 	FAT1	0.573	other	 	-1.179	bias	0.390	-2.040	3.46E-03	IL6,JUN,PDCD4,PTGS2,VEGFC	Ap1,FAT1,FOS,JUN,NFkB (complex),RELA,SP1	
P1	 	MEMO1	-0.002	other	 	-0.626	bias	0.501	 	3.46E-03	CTSD,FOS,JUN,MYC,STC2	Akt,Ap1,ERK1/2,ESR1,ESR2,HIF1A,JUN,MEMO1,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,estrogen receptor	
P1	 	TPM3	0.059	other	 	-0.447	bias	-0.501	 	3.46E-03	ITGA1,ITGA3,MMP2,TEK,TNFRSF10B	 	
P1	 	bevacizumab	 	biologic drug	 	0.555	 	-0.056	0.678	3.46E-03	ANGPT1,CXCL12,CXCR4,KDR,NRP1	Ap1,CTNNB1,ETS1,HDAC1,NFkB (complex),NOTCH1,RELA,STAT3,VEGFA,Vegf,bevacizumab	
P1	 	hexamethoxyflavone	 	chemical toxicant	 	0.507	bias	-0.501	 	3.46E-03	CXCL8,IL6,MMP9,PTGS2,VCAM1	Akt,Ap1,ERK,ESR1,HIF1A,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,SMAD3,SP1,STAT3,TP53,hexamethoxyflavone,prostaglandin E2	
P1	 	ketorolac	 	chemical drug	 	-0.625	 	-0.125	-0.351	3.46E-03	CXCL8,HIF1A,IL6,NFKBIA,PTGS2	Ap1,CREB1,CTNNB1,FOS,GATA4,HDAC3,HDAC4,IFNB1,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),PPARG,PTGS2,RELA,SP1,STAT1,STAT3,TP53,dinoprost,ketorolac,leukotriene C4,prostaglandin E2	
P1	 	tiron	 	chemical reagent	 	-1.342	bias	-0.390	-0.470	3.46E-03	AGT,HMOX1,HSPA5,IL6,PLAUR	ATF2,Ap1,EGFR,EP300,FOS,JUN,MAPK8,NADPH oxidase,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,SRC,STAT3,tiron	
P1	 	voltage-gated calcium channel	 	complex	 	0.600	bias	0.390	-0.258	3.46E-03	ACTA1,CCND2,ITGAM,ITPR2,NR4A2	CREB1,Ca2+,NFkB (complex),SP1,STAT3,TP53,voltage-gated calcium channel	
P1	 	CBFB	-0.319	transcription regulator	 	1.981	 	-0.015	2.043	3.56E-03	ATF4,CD4,COCH,CSF1R,HEY1,LGMN,NRP1,PDE3B,PTGER4,RAB3IP,RGS1,RUNX1,SLC25A19,SOCS2,SPP1,TGFBR2,TGFBR3,TNFRSF4,TPSAB1/TPSB2	CBFB,CEBPA,HDAC1,JUN,RUNX1,SPI1	
P1	 	LMNA	0.561	other	 	 	 	 	 	3.60E-03	ARRDC4,BAMBI,C2orf40,CAAP1,CCNG2,CERS6,COL11A1,COL12A1,COL1A1,COL3A1,COL8A1,CSTF2,CTDSPL,EDN1,ELK1,EPB41L3,ERN1,GULP1,H3F3A/H3F3B,ID3,IGF2R,ISG20,JUN,KANK3,KIAA1551,LEP,LMNA,MAP3K8,MAPKAP1,MSC,NDST2,PCDH7,PKD1,RCCD1,RHPN2,RPS21,SEMA3G,SLC41A2,SMG7,SNRK,ST6GALNAC4,STAB1,TNMD,ZFP36	Ap1,ERK1/2,FOS,JUN,Jnk,LMNA,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3	
P1	 	4-hydroxytamoxifen	 	chemical drug	 	0.340	 	0.182	-0.631	3.62E-03	BCL2L1,CD55,CEBPD,COL16A1,CTSD,DDIT4,ESR1,FOS,GLRX,GM2A,HDGF,IER3,IGFBP3,IL6,JUNB,MYC,NEDD9,PDK4,PTTG1,RARA,RBP4,RPS6KA4,S100A9,S100P,SGK1,SLC39A8,TM4SF1,TMEM97,TMOD1,TPM1,ZNF91	4-hydroxytamoxifen,Akt,CEBPB,ESR1,ESR2,FOS,HIF1A,IGF1,JAK2,JUN,NFKB1,NFkB (complex),SMAD3,SP1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	gemfibrozil	 	chemical drug	 	1.060	 	0.225	0.120	3.74E-03	ACADVL,APOE,DECR2,ECI1,GADD45A,HADHA,IL6,LDLR,MBP,MYC,NFKBIA,ORM1,PCSK5,PDCD4,POR,RTN4,SOCS3,TPP1	APP,Ap1,CEBPB,HIF1A,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT1,STAT3,THRB,gemfibrozil	
P1	 	HBEGF	-1.351	growth factor	 	-0.048	bias	0.301	-0.988	3.75E-03	ANGPTL4,BMP2,CCND2,CSF1R,CXCR4,ELN,FGF2,MMP9,NRP1,PDK4,PTGS2	AKT1,Akt,ERK1/2,HBEGF,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TP53	
P1	 	green tea polyphenol	 	chemical drug	 	-0.323	 	-0.125	0.088	3.75E-03	ADIPOQ,CAV1,DLG4,FOS,HMOX1,IGFBP3,IL6,JUN,MMP2,MMP9,PTGS2	Ap1,ERK,ERK1/2,ESR1,FOS,JUN,MAPK8,NFATC2,NFKBIA,NFkB (complex),Nfat (family),P38 MAPK,RELA,SMAD3,STAT3,green tea polyphenol	
P1	 	honokiol	 	chemical - endogenous non-mammalian	 	0.379	 	-0.091	0.615	3.75E-03	ADIPOQ,BCL2L1,CCND2,CDK4,FOS,JUNB,KDR,MAP3K8,MCL1,MMP9,PTGS2	Akt,Ap1,ERK1/2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT3,TNF,TP53,honokiol	
P1	 	monocrotaline	 	chemical toxicant	 	0.471	 	0.076	0.234	3.75E-03	ATP2A2,FHL1,GAP43,HMOX1,ID1,ID3,IL6,NGF,SLC9A1,SMAD6,SPP1	ERK1/2,GATA4,NFKBIA,NFkB (complex),NOTCH1,RELA,RUNX2,SMAD1,SMAD3,SP1,STAT3,Smad,monocrotaline	
P1	 	phorbol 12,13-dibutyrate	 	chemical - endogenous non-mammalian	Inhibited	-2.504	 	0.146	-2.959	3.75E-03	CCND2,CCNG2,CD55,CXCL8,FOS,MAP3K8,PRKCD,PRKCE,PRNP,PTGS2,SPRY2	Akt,Ap1,CREB1,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PRKCA,PRKCE,Pkc(s),RELA,STAT1,STAT3,TP53,phorbol 12,13-dibutyrate	
P1	 	ICMT	0.118	enzyme	 	 	 	 	 	3.83E-03	AEBP1,CRABP1,GDI1,GPC4,HBEGF,LARGE1,LMNA,SERINC1,SLIT3	 	
P1	 	rimonabant	 	chemical drug	 	-1.879	 	-0.221	-1.236	3.83E-03	ADIPOQ,CXCL8,FGF2,FOS,HSPA5,IL6,MMP9,NGF,PTGS2	AMPK,Ap1,CEBPB,ERK1/2,FOXO1,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PPARGC1A,RELA,SMAD3,STAT1,STAT3,TP53,cyclic AMP,rimonabant	
P1	 	KLF6	-0.821	transcription regulator	 	-0.929	 	0.036	-1.065	3.90E-03	ATF3,BCL2L1,CCL2,CCL3L3,CDH2,COL1A1,CXCL2,CXCL8,MCL1,MMP9,MYC,NFKBIA,NR1D1,NR2F6,PTGS2,SERPINH1,TFPI2	Akt,Ap1,FOS,HIF1A,JUN,KLF6,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TP53	
P1	 	caffeine	 	chemical drug	 	0.866	 	0.017	0.804	3.90E-03	ACP5,CAT,CAV1,CTGF,CTSK,CUL7,CXCL8,EGR1,EPAS1,FOS,FOSB,HIF1A,HSD11B2,JUNB,PTGS2,SRSF3,THBS1	CEBPB,ERK,ERK1/2,HIF1A,IGF1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,caffeine	
P1	 	lomustine	 	chemical drug	 	1.739	bias	0.423	-0.000	3.90E-03	ASNS,BIRC3,CAPN6,CD14,EMP3,GPNMB,GSTM3,IER3,LXN,MYC,RCN1,SPP1,TIMP1,TNFRSF10B,TNFRSF12A,TUBB,UPP1	 	
P1	 	6-cyano-7-nitroquinoxaline-2,3-dione	 	chemical reagent	 	1.997	bias	-0.501	 	3.92E-03	EGR1,FOS,JUN,JUNB	6-cyano-7-nitroquinoxaline-2,3-dione,AR,PRL,SP1,STAT1,STAT3,TP53	
P1	 	CYB5R4	-0.320	enzyme	 	-0.958	bias	-0.334	-0.296	3.92E-03	ATF3,ATF6,DDIT3,HSPA5	 	
P1	 	Cdk	 	group	 	-1.980	bias	0.501	 	3.92E-03	CCL2,CXCL2,CXCL8,IL6	 	
P1	 	PPM1B	0.271	phosphatase	 	-1.000	bias	0.334	-1.669	3.92E-03	CCL3L3,CEBPD,HBEGF,MARCO	Ap1,IKBKB,NFKB1,NFKBIA,NFkB (complex),PPM1B,RELA	
P1	 	YES1	-0.020	kinase	 	 	 	 	 	3.92E-03	HMOX1,IL6,NQO1,NQO2	AKT1,Ap1,BACH1,FOXO1,GAB1,HIF1A,JUN,Jnk,MYC,NFE2L2,NFKB1,NFkB (complex),NOS2,RELA,SP1,STAT1,STAT3,TP53,YES1	
P1	 	ferric nitrilotriacetate	 	chemical toxicant	 	 	 	 	 	3.92E-03	BCL2L1,ID3,KLF4,PTGS2	 	
P1	 	nicotinic acetylcholine receptor	 	complex	 	0.000	bias	0.334	-0.669	3.92E-03	FOS,ID1,JUN,JUNB	CREB1,Ca2+,Creb,FOS,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,nicotine,nicotinic acetylcholine receptor	
P1	 	non-esterified fatty acid	 	chemical - endogenous mammalian	 	-1.000	 	-0.167	-0.666	3.92E-03	APOB,APOE,IL6,LDLR	CEBPA,CEBPB,FOS,IL6,Ins1,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,STAT3,non-esterified fatty acid	
P1	 	saquinavir	 	chemical drug	 	-1.067	 	0.000	-1.067	3.92E-03	LIPE,MMP9,MYC,NFKBIA	CEBPA,CEBPB,CTNNB1,FOS,Ins1,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,PPARA,PPARG,RELA,STAT3,saquinavir	
P1	 	teichoic acid	 	chemical - endogenous non-mammalian	 	0.254	bias	0.501	 	3.92E-03	HIF1A,IL6,MMP2,PTGS2	 	
P1	 	SNCA	0.077	enzyme	 	0.329	 	-0.043	0.456	3.95E-03	BCL2L1,CRYM,CTSB,DDIT3,GSK3B,HSPA5,ITPA,KIF1A,KIF2A,LRRK2,MMP9,NCF2,NOTCH1,PSMA3,PYGB,SYN1,SYN2,TRIB3,TUBG1,UCHL1	APP,Ap1,CREB1,CTNNB1,FOS,GSK3B,HIF1A,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,Pkc(s),RELA,SNCA,STAT1,STAT3,baicalein	
P1	 	ANGPT1	-1.172	growth factor	 	-0.400	 	0.091	-0.655	4.00E-03	ACTA1,ALCAM,BCL2L1,CCL2,CDH5,COL3A1,DUSP1,DUSP5,EFNB2,SELE,TEK,VCAM1	ANGPT1,Akt,CEBPB,ERK1/2,HIF1A,JUN,MAP2K1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,RHOA,SMAD3,SP1,STAT3,TP53	
P1	 	alvocidib	 	chemical drug	 	-0.440	bias	-0.396	0.879	4.00E-03	AEN,BCL2L1,BIRC3,CCL2,CCND3,ERBB2,FOS,ITGAM,MCL1,MYC,TCEA1,TXN	Akt,HIF1A,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,TP73,alvocidib	
P1	 	histone deacetylase	 	complex	 	1.554	bias	-0.267	2.437	4.00E-03	CSF2RA,CXCR4,CYR61,JUNB,KEAP1,LHCGR,MMP9,NOTCH1,PLAT,PTGIS,SLC7A8,THBS1	AR,CEBPA,ERK1/2,HDAC1,JUN,MYC,NCOR1,NFKBIA,NFkB (complex),NR3C1,PPARG,RELA,SMAD3,SP1,STAT3,TP53,histone deacetylase	
P1	 	TAL1	-0.205	transcription regulator	 	0.426	bias	0.267	-0.315	4.01E-03	ADGRG1,ARSA,CDH5,DOCK1,EPB42,FAM86C1,FCER1A,HADHA,HSD17B14,IL10RA,KIT,LRBA,MS4A2,MVD,MYC,NOTCH1,NR4A3,PLA2G2A,SLC4A11,SPI1,TPSAB1/TPSB2,UBXN1	ID3,TAL1,TCF3	
P1	 	Tnf (family)	 	group	 	-1.489	bias	0.267	-2.910	4.04E-03	ABCC3,ADIPOQ,ATF3,BCL2L1,BIRC3,CCL2,CCL3,CCL8,CD163,CD4,CD86,CDK4,CXCL12,CXCL8,ENPP2,FST,HIF1A,IL6,MMP9,NFKBIA,NOX4,POMC,PTGS2,RPS6KA4,SAA1,SELE,SOCS3,TNFAIP3,TNFRSF4,TYMP,VCAM1	Ap1,ERK1/2,IL1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,Tnf (family),prostaglandin E2	
P1	 	POLR2A	0.205	enzyme	 	 	 	 	 	4.12E-03	ANO1,BCL2L1,BMF,CAV1,CXCR4,EGR2,FOS,GAPDH,HNRNPH1,HOXA9,MYC,NFKBIA,SELE,STC2,TNFAIP3	 	
P1	 	YBX1	-0.167	transcription regulator	 	-0.028	bias	0.288	-1.046	4.12E-03	CDC34,COL1A1,COL1A2,CXCL2,FOS,ID1,IGFBP3,KLF4,MMP2,PTGS2,PTPA,RELN,SLC2A3,SPON1,STC2	CEBPB,IL17A,IL6,JUN,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,YBX1	
P1	 	rifampin	 	chemical drug	Activated	2.601	bias	0.363	1.177	4.12E-03	ABCC1,ABCC3,ABCG1,ATP2B1,AXIN2,CARS,CD14,CD24,CD36,CD59,CES1,CES2,COL6A1,CYP2C8,CYP4B1,EIF5,ELK1,ENPP2,FMO4,IFRD1,ITGAM,MATN2,ME1,MGP,MME,MT1G,NAGK,PCK2,PLEC,PNRC2,SPOCD1,SPP1	 	
P1	 	quinolinic acid	 	chemical - endogenous mammalian	 	-1.466	 	0.050	-1.628	4.13E-03	BCL2L1,CAT,EGR1,FOS,FOSB,HSPA1A/HSPA1B,JUN,JUNB,MYC,NGF,NTRK3,PTGS2,RET	Ap1,CREB1,EPO,ESR1,FOS,FOXO3,HIF1A,JUN,L-glutamic acid,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),RELA,STAT1,STAT3,quinolinic acid	
P1	 	thymoquinone	 	chemical - endogenous non-mammalian	 	-0.923	 	-0.029	-0.836	4.13E-03	BCL2L1,BMP2,CAT,CD14,CDK4,COL1A1,COL3A1,CXCR4,HMOX1,MCL1,MMP9,PTGS2,TNFSF10	Akt,Ap1,CEBPA,CEBPB,ERK,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53,thymoquinone	
P1	 	2-bromoethylamine	 	chemical reagent	 	1.183	bias	0.440	-0.453	4.16E-03	ADAMTS1,CAPN6,CD14,EFEMP2,EMP3,GPNMB,IER3,LXN,MYC,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	ADM	-0.833	other	 	0.767	 	-0.061	0.932	4.16E-03	ADM,AGT,CXCL2,EDN1,FGF2,FOS,HIF1A,HRAS,IL6,PTGS2,RAMP2,RAMP3,SPP1,VCAM1	ADM,EDN1,ERK1/2,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,RELA,SMAD3,SP1,STAT3,aldosterone	
P1	 	LGALS1	-0.065	other	 	0.637	bias	0.313	-0.467	4.16E-03	ANG,CCND2,CD69,CXCL16,CXCL2,HBEGF,HLA-G,HRAS,IL6,LEP,MAF,MMP2,MMP9,PTX3	Akt,Ap1,FOS,HIF1A,HRAS,IFNG,JUN,LGALS1,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,TP53	
P1	 	ZFP36	-2.961	transcription regulator	 	1.514	bias	-0.469	2.958	4.16E-03	BIRC3,CCL3L3,CD36,CXCL2,FOS,HIF1A,IER3,IL6,PTGS2,S100A8,S100A9,SPP1,VCAM1,ZFP36	CREB1,CSF2,IL6,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,ZFP36	
P1	 	AMPK	 	complex	 	-0.384	 	0.093	-0.794	4.19E-03	ACACA,ACO2,ADIPOQ,BMF,BMP2,CAT,CCL2,CCND2,CS,CXCL12,CXCL8,EGR1,FSCN1,HIF1A,HMOX1,IL6,LITAF,LPIN1,MMP9,NOX4,PFKFB3,PTGS2,STIM1,THRSP,UCP2	AMPK,Akt,Ap1,CEBPB,ERK1/2,ESR2,HIF1A,JUN,Jnk,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,PGR,RELA,SMAD3,STAT3,TP53,progesterone	
P1	 	Creb	 	group	 	0.312	bias	0.391	-1.478	4.21E-03	ADIPOQ,ADM,ANTXR1,ATP2A2,CD14,CD59,CEBPD,CIDEC,COL8A1,CSF1R,CTSB,CXCL8,CYP51A1,DDX28,DUSP1,EGR1,EIF4EBP2,ETV5,FCER1G,FOS,FSCN1,GSTM3,HLA-G,IER3,IL6,ITGAM,JUN,JUNB,LDLR,LEP,LMO4,MCAM,MIF,MMP2,NEDD9,NMNAT2,NR4A3,ORM1,PDE3B,PLAT,PTGS2,RET,RNASEH2A,SOX17,SOX9,TF	Ap1,CREBBP,CTNNB1,Creb,EP300,ESR1,FOXO1,HDAC1,HIF1A,Histone h3,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RNA polymerase II,RXRA,SP1,STAT1,STAT3,TCF	
P1	 	ACKR1	-0.089	g-protein coupled receptor	 	 	 	 	 	4.24E-03	CCL2,LOC102724428/SIK1,MYO5A,NINJ1,SELE,TBC1D8,TNFAIP3,VCAM1	 	
P1	 	FBN1	0.070	other	 	0.000	bias	-0.446	1.083	4.24E-03	COL1A2,COL3A1,COL6A3,CTGF,CYR61,MMP2,MMP9,TGFBR2	Ap1,EGR1,ERK,ESR1,FBN1,JUN,NFkB (complex),RELA,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TGFB1,TP53	
P1	 	FOXC1	-0.755	transcription regulator	 	-0.324	bias	0.442	-1.473	4.24E-03	CXCR4,EFNB2,MESP1,MMP9,NOTCH1,PIN1,PLOD1,TSC22D1	FOXC1,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P1	 	FUT8	-0.160	enzyme	 	0.822	bias	-0.263	1.556	4.24E-03	ALDH2,CYP1B1,ELN,GSTM3,GSTM5,SMAD7,SQLE,TFRC	 	
P1	 	JUN/JUNB/JUND	 	group	 	0.277	 	0.100	0.055	4.24E-03	BCL2L1,COL7A1,CYR61,FOS,HMOX1,IL6,JUN,PDCD4	Ap1,BACH1,CREB1,EP300,ESR2,ETS1,FOS,HDAC1,JUN,JUN/JUNB/JUND,NFE2L2,NFKB1,NFkB (complex),RELA,RNA polymerase II,SP1,TP53	
P1	 	MAP2K5	0.536	kinase	 	-1.098	bias	0.396	-2.201	4.24E-03	ACTA1,CXCL8,FOS,JUN,KLF2,MMP9,NR4A3,PTGS2	Ap1,BACH1,CTNNB1,ESR1,JUN,MAP2K5,MAPK7,MMP9,NFATC2,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NOTCH1,Nfat (family),PPARG,RELA,STAT3	
P1	 	NOTCH4	-0.450	transcription regulator	Inhibited	-2.138	bias	0.358	-3.145	4.24E-03	ANGPT1,C21orf33/LOC102724023,EFNB2,HEY1,HEY2,NOTCH1,PRAG1,TEK	 	
P1	 	mangiferin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.24E-03	ACACA,BCL2L1,CD36,DGAT2,HMOX1,MMP9,NQO1,PTGS2	Akt,Ap1,CAT,FOXO1,Growth hormone,HIF1A,Insulin,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,STAT1,STAT3,TP53,mangiferin	
P1	 	miR-124-3p (and other miRNAs w/seed AAGGCAC)	 	mature microrna	 	-1.459	bias	-0.501	 	4.25E-03	ABHD5,AK2,APEX2,BTG3,CAV1,CCL2,CD59,CDK4,CTGF,CYP1B1,DCTD,DHCR24,DNAJC1,DVL2,EGR1,F11R,FAM129B,GNG10,KANK1,LDLR,LDLRAP1,LIMCH1,LITAF,MAD2L2,MYO10,NECAP2,OAF,PDLIM7,PHF19,PLOD3,PLP2,RASSF5,RAVER2,RNPEPL1,SLC15A4,SLC22A5,SOX9,STOM,SWAP70,TJP2,TMBIM1,TNFRSF21,TRIM29,TSC22D4,ZFP36L2	 	
P1	 	COL1A1	2.336	other	 	-0.492	bias	0.376	-1.326	4.34E-03	CCL2,COL1A1,CXCR4,EDN1,SELE,VCAM1	ATF2,COL1A1,CTNNB1,EGFR,HIF1A,ITGB1,NFkB (complex),SMAD3,SP1,STAT1,STAT3,STAT5a/b	
P1	 	CSF2RA	0.721	transmembrane receptor	 	-1.546	bias	0.424	-2.577	4.34E-03	CCND2,FOS,ITGAM,JUN,JUNB,MYC	Akt,CEBPA,CEBPB,CSF2RA,ELK1,FOS,HIF1A,JAK2,JUN,MAPK3,NFkB (complex),RELA,STAT1,STAT3,STAT5a/b,TP53	
P1	 	CYP51A1	0.950	enzyme	 	-0.816	bias	-0.270	-0.155	4.34E-03	DHCR24,LSS,MSMO1,RARA,SQLE,TM7SF2	 	
P1	 	EPHA2	-0.173	kinase	 	-0.218	 	-0.084	-0.018	4.34E-03	HRAS,MMP9,SELE,SLIT2,TJP1,VCAM1	Akt,EPHA2,Focal adhesion kinase,HIF1A,JUN,NFKB1,NFkB (complex),PPARG,PTK2,RELA,RHOA,SMAD3,SP1,SRC,STAT1,STAT3,TP53	
P1	 	LPAR1	0.772	g-protein coupled receptor	 	-1.561	bias	0.501	 	4.34E-03	CTGF,CXCL8,IL6,MMP9,PTGS2,S1PR3	Akt,ERK,Gm-csf,HIF1A,JUN,LPAR1,NFKB1,NFkB (complex),PPARG,RAC1,RELA,RHOA,SMAD3,STAT3,STAT5a/b,TP53	
P1	 	PLCG1	0.348	enzyme	 	0.431	 	0.167	0.032	4.34E-03	CCL2,CCND3,EGR1,FOS,KDR,THBS1	CREB1,ELK1,ERK,FOS,HDAC2,Hdac,JUN,NFKB1,NFkB (complex),PLCG1,PRKCE,Pkc(s),RELA,Ras,SMAD3,SP1,SRF,STAT1,STAT3	
P1	 	SYK/ZAP	 	group	 	-1.016	bias	0.501	 	4.34E-03	CD69,IL6,PTGS2,TIMP1,VCAM1,VEGFC	Ap1,CREB1,CTNNB1,Immunoglobulin,JUN,MYD88,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PIK3R1,RELA,STAT1,STAT3,STAT6,SYK/ZAP,TP53	
P1	 	TLE1	-0.797	transcription regulator	 	 	 	 	 	4.34E-03	ATF3,DUSP1,EGR1,FOS,MCL1,NUPR1	CTNNB1,HDAC1,HDAC2,SIN3A,SP1,TLE1,TP53	
P1	 	TMBIM6	0.278	other	 	-0.186	 	0.039	-0.279	4.34E-03	DDIT3,EDEM1,ERN1,HMOX1,HSPA5,SEC61A1	ATF6,CREB1,Ca2+,Creb,DDIT3,ERN1,NFkB (complex),SP1,STAT3,TMBIM6,TP53,XBP1	
P1	 	clenbuterol	 	chemical drug	 	0.600	bias	0.251	0.048	4.34E-03	ADRB2,BCL2L1,CAST,MYH1,NGF,SOCS3	Akt,HIF1A,JUN,NFkB (complex),STAT3,TP53,clenbuterol	
P1	 	prazosin	 	chemical drug	Activated	2.000	bias	-0.501	 	4.34E-03	CCL2,DUSP1,EGR1,FOS,IL6,MYC	Ap1,ERK1/2,FOS,FOXO1,Growth hormone,HIF1A,Insulin,JUN,Jnk,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SMAD3,STAT3,prazosin	
P1	 	ANXA1	0.376	enzyme	 	-0.336	 	-0.125	-0.002	4.43E-03	CCL2,CD69,CXCR4,FARSA,IL6,ITGAM,ITGB1BP1,PLA2G4A,POMC,PTGS2	ANXA1,EP300,FOS,IL1B,JUN,MAPK1,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,RNA polymerase II,SP1,STAT1,STAT3,hydrocortisone	
P1	 	CTF1	0.105	cytokine	 	-0.083	 	0.100	-0.280	4.43E-03	AGT,CEBPD,FOS,JUNB,LBP,LEP,POMC,SERPINA3,SOCS3,TIMP1	CEBPA,CEBPB,CTF1,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT,STAT1,STAT3,TP53	
P1	 	Focal adhesion kinase	 	group	 	0.285	 	0.093	0.009	4.43E-03	CDH2,CDKN1C,EFNB2,IL6,KRT8,LPP,MMP2,MMP9,TAGLN,VCAM1	Akt,Ap1,ERK1/2,Focal adhesion kinase,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,RAC1,RELA,RHOA,SMAD3,STAT3,TP53	
P1	 	IFRD1	0.902	other	 	-1.289	bias	-0.267	-0.452	4.43E-03	CRABP2,CTGF,DGAT2,FEM1A,HK1,LAMA2,MYC,PTTG1,SPP1,SYN1	CTNNB1,HDAC1,IFRD1,JUN,NFkB (complex),STAT3,TCF	
P1	 	MAPK7	0.800	kinase	 	-0.854	 	0.241	-1.600	4.43E-03	CDH2,CXCL2,EDN1,HMOX1,JUN,KLF4,MAPK7,MCL1,NQO1,PTGS2	Ap1,FOS,FOXO1,HIF1A,JUN,MAPK7,NFKB1,NFKB2,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3	
P1	 	TIMP1	0.956	cytokine	 	1.265	 	0.052	1.101	4.43E-03	BCL2L1,CTSG,FCER2,IGFBP3,MME,MMP2,MMP9,PLAT,PLAUR,PLTP	Akt,CD44,CTNNB1,ELK1,FOXO1,HIF1A,JUN,MMP1,MMP9,NFKB1,NFkB (complex),NOTCH1,PTK2,RELA,SMAD3,STAT1,STAT3,TIMP1,TP53	
P1	 	eplerenone	 	chemical drug	 	-0.611	bias	-0.368	0.518	4.43E-03	ADIPOQ,CD68,CTGF,CYBA,EDN1,MMP2,NOX4,PTGS2,SPP1,VCAM1	IL1B,IL6,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,Nfat (family),RELA,SP1,STAT1,STAT3,TNF,aldosterone,eplerenone	
P1	 	MMP1	0.042	peptidase	 	1.005	 	0.188	0.523	4.49E-03	CXCL12,EGR1,HIF1A,KDR,MMP9,PLTP,TAGLN	Ap1,CTGF,CTNNB1,Creb,ETS1,F2R,FLI1,IL1B,JUN,MMP1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,VEGFA	
P1	 	PECAM1	-0.180	other	 	0.665	 	-0.215	1.179	4.49E-03	BCL2L1,CD36,CDH5,IL6,ITGAM,MMP2,THBS1	Akt,Ap1,CEBPA,CEBPB,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PECAM1,RELA,SP1,STAT1,STAT3,TNF,TNFRSF1A,TP53	
P1	 	TREM2	0.382	transmembrane receptor	 	1.909	 	-0.029	1.985	4.49E-03	CCL3L3,CD86,CXCL2,IL6,NFKBIA,PTGS2,TNFAIP3	Ap1,CTNNB1,ERK,IFNG,JUN,NFAT (complex),NFkB (complex),RELA,SMAD3,STAT1,STAT3,TREM2,TYROBP,nitric oxide	
P1	 	batimastat	 	chemical - protease inhibitor	 	0.816	 	0.063	0.663	4.49E-03	ANG,FCER2,FGF2,LIPE,MMP2,MMP9,SDC4	CTNNB1,CX3CL1,ERK,ERK1/2,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,SMAD3,STAT3,batimastat	
P1	 	magnolol	 	chemical - endogenous non-mammalian	 	0.849	 	-0.228	1.300	4.49E-03	CXCL8,FOS,HIF1A,IL6,MMP2,MMP9,PTGS2	Akt,Ap1,CREB1,ERK1/2,FOS,HIF1A,JUN,Jnk,MAPK8,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,STAT3,TP53,magnolol	
P1	 	oxysterol	 	chemical - endogenous mammalian	 	0.610	bias	0.265	-0.082	4.49E-03	ABCG1,APOE,CAV1,CCL2,CXCL8,MYC,TIMP1	Ap1,IL1A,JUN,NFKBIA,NFkB (complex),Nr1h,RELA,RXRA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,oxysterol	
P1	 	CEBPD	-1.069	transcription regulator	 	-0.215	bias	0.255	-1.238	4.62E-03	AGT,ASNS,B9D1,CCL3L3,CD14,CDKN1C,CEBPD,CSF1R,CSF3R,CXCL8,FOS,HP,IL6,ITGAM,LEP,MBP,MIA,MYC,NGF,PTGS2,SFTPD,VEGFC	Ap1,CEBPD,CREBBP,EP300,FOXO1,HDAC4,HIF1A,IL6,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,PTGS2,RELA,RXRA,SP1,STAT1,STAT3,TP53	
P1	 	MEF2C	-0.129	transcription regulator	Inhibited	-2.049	bias	0.342	-3.517	4.62E-03	ACTA1,ATP2A2,CASQ2,CLSTN2,COL1A1,COL1A2,COL3A1,ECM2,FRZB,HSPB7,JUN,KCNJ2,KLF2,LOC102724428/SIK1,MYH1,MYOM1,MYOM2,PLA2G2A,PTPRB,SFRP2,SRPK3,TPM1	GATA4,MEF2C,RXRA	
P1	 	PRKAA1	-0.207	kinase	 	-1.254	bias	-0.370	0.430	4.62E-03	ACOT7,ATF3,CD302,CXCL12,CXCL8,GALM,HIGD1A,IGFBP4,IL6,LMO4,MMP9,MYLK,NCF2,NFKBIA,PARP3,PCOLCE,SERPINI1,SOCS3,SORL1,TGM2,THRSP,TTYH1	AMPK,Ap1,FOXO1,FOXO3,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARA,PPARD,PPARG,PPARGC1A,PRKAA1,PRKAA2,RELA,SP1,SREBF1,STAT1,STAT3,TP53,fatty acid,palmitic acid	
P1	 	HDAC3	0.210	transcription regulator	Activated	2.208	 	-0.178	2.701	4.63E-03	BIRC3,CD55,CDH2,COL1A2,CXCL2,CXCL8,ENPP2,FOS,HMOX1,MMP9,MYC,NFKBIA,PHLPP1,PTGS2,SMAD7,SPP1,TAGLN	Ap1,ESR1,ETS1,EZH2,FOS,HDAC1,HDAC3,HIF1A,Histone h3,JUN,MAPK8,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SIN3A,SMAD3,SMAD4,SNAI1,SP1,STAT3,TGFB1	
P1	 	miR-30c-5p (and other miRNAs w/seed GUAAACA)	 	mature microrna	Inhibited	-2.208	bias	-0.501	 	4.76E-03	ADPGK,ATP2A2,CTGF,IDH1,IFRD1,IL6,IRS2,JUN,MAP4K4,MYO10,NCL,NPR3,P4HA2,PTPA,PTPRK,PTRH1,SLC38A1,SLC4A7,SLC7A1,STX1A,TMED2,TMED3,TMEM41B,TNFRSF10B,UBE2I	 	
P1	 	CD44	0.141	enzyme	 	0.039	bias	0.334	-1.603	4.78E-03	ADRB2,BCL2L1,BIRC3,CCND2,CD36,CD69,CDH5,CIDEA,CIDEC,COL18A1,COL1A1,COL3A1,COL5A2,CRABP2,CTSK,DDIT3,EMILIN1,ERBB2,FKBP4,GADD45A,IL6,ITGA3,JUN,KCTD10,LTBP2,MCL1,MMP2,MMP9,PDCD4,PMEPA1,SDC4,SPP1,SRC,THBS1,THY1,VCAM1,WBP2	Akt,Ap1,CD44,ERBB2,FGF2,HIF1A,JUN,MYC,NFkB (complex),PI3K (complex),SMAD3,SMAD4,SP1,STAT3,TGFB1,TP53,estrogen receptor	
P1	 	MYOD1	-0.095	transcription regulator	 	0.344	bias	0.280	-1.122	4.79E-03	ACACA,ACTA1,ADORA1,AGT,ALDOA,ASS1,BCL2L1,BIN1,CBX5,CCND3,CDKN1C,CDO1,DUSP1,ENPP2,ESR1,FNDC5,FYN,GADD45A,GYS1,HDAC11,HES6,ITGA7,JUNB,KLF6,MMP2,MSC,PMEPA1,RBM38,RUNX1,SH3GLB1,SLC12A2,SMAD7,SPTBN1,SRC,SUSD2,TGFBR3,TJP1,TNS1	Akt,CREBBP,EP300,HDAC1,HIF1A,Hdac,Histone h4,JUN,MYOD1,NFkB (complex),RELA,RNA polymerase II,SMARCA4,SP1,SP3,STAT1,STAT3,TP53	
P1	 	GAPDH	1.022	enzyme	 	-0.474	 	-0.206	0.195	4.82E-03	BCL2L1,C2,CCL2,CCL3,DUSP1,ENO1,FCER1G,GAPDH,IFIT2,SPP1,WARS	GAPDH,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P1	 	SPHK1	0.482	kinase	Inhibited	-2.013	 	0.076	-2.260	4.82E-03	COL1A2,CTGF,CXCL8,DDIT3,EGR1,ERN1,IL6,JUN,PTGS2,SOCS3,TIMP1	Ap1,CREB1,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,SPHK1,STAT3,sphingosine-1-phosphate	
P1	 	phenylbutazone	 	chemical drug	Activated	2.121	bias	0.384	0.599	4.82E-03	ADAMTS1,ASNS,CAPN6,EFEMP2,GPNMB,GSTM3,IDO1,IER3,LXN,PTGS2,RCN1,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,phenylbutazone	
P1	 	clofibrate	 	chemical drug	 	1.127	bias	0.253	-0.072	4.91E-03	ABCC3,ACADVL,ACOT4,BSG,CCND2,CD36,CXCL8,DECR2,ECI1,GADD45A,HADHA,HMOX1,IL6,LDLR,MYC,NQO1,PDCD4,PTGS2,RTN4,SLC27A1,SLCO2A1,SLCO2B1,UCP2	ACOX1,ATF6,Akt,Ap1,CAT,HIF1A,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,RXRA,SREBF1,STAT1,STAT3,TP53,clofibrate,oleic acid	
P1	 	daidzein	 	chemical drug	 	0.951	 	0.143	0.312	4.96E-03	ABCC3,ADIPOQ,AKR1C3,CAV1,CCL2,CD4,CD86,DNASE1L3,DNPH1,ERBB2,ESR1,FERMT3,FOSB,HCST,IL6,LDLR,MAL2,MYC,PLCXD3,PTGS2,VPS52	Ap1,CEBPB,ERK,ESR1,ESR2,JUN,LDL,NFKB1,NFKB2,NFKBIA,NFkB (complex),PGR,RELA,SMAD3,SP1,STAT3,beta-estradiol,daidzein,ethanol,progesterone	
P1	 	BIRC5	0.281	other	 	 	 	 	 	4.98E-03	BCL2L1,C1QC,COL1A1,COL3A1,COL5A2,COL8A1,CTGF,DPT,JCHAIN,LUM,LYZ,MCL1,MMP2,UVRAG,VEGFC	Ap1,BCL2,BIRC5,EGR1,ESR1,ETS1,HIF1A,JUN,MAX,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,TP73,VEGFA	
P1	 	F2RL1	0.050	g-protein coupled receptor	Inhibited	-2.569	bias	0.406	-3.997	4.98E-03	CAV1,CCL2,CTGF,CTSD,CXCL8,CYR61,FOS,GBP4,HBEGF,IL6,MMP9,MSC,PELI1,PTGS2,VEGFC	Ap1,ERK1/2,F2RL1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARG,RELA,RHOA,SMAD3,SP1,STAT3,prostaglandin E2	
P1	 	SERPINF1	0.316	other	 	0.704	 	-0.023	0.784	4.98E-03	ADIPOQ,AXIN2,BCL2L1,CDH5,CSPG4,CTGF,CXCL8,CYBA,G0S2,MYC,NFKBIA,NGF,THBS1,TJP1,TNFSF10	Akt,CTNNB1,HDAC1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SERPINF1,SP1,STAT1,STAT3,TCF,TP53	
P1	 	H-7	 	chemical - kinase inhibitor	 	1.839	bias	-0.424	3.268	5.03E-03	ALDH3A1,COL1A1,COL1A2,EGR1,FCER2,FOS,HDC,IFIT2,JUNB,MYC,SAA1,SELE	Ap1,CEBPA,CEBPB,ELK1,FOS,H-7,IL6,JUN,MAPK3,MAPK8,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TP53	
P1	 	carrageenan	 	chemical - endogenous non-mammalian	Inhibited	-2.894	bias	0.474	-4.490	5.03E-03	CCL3L3,CXCL2,CXCL8,EGR1,EGR2,FOS,FOSB,JUN,JUNB,KIT,NGF,PTGS2	Ap1,ESR2,FOS,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,carrageenan,prostaglandin E2	
P1	 	3-methylcholanthrene	 	chemical toxicant	 	-1.250	bias	0.424	-2.519	5.08E-03	ADM,ALAS2,CD36,CYP1B1,CYR61,FOS,GSR,GSTM1,GSTM5,HP,ME1,NQO1,POR,PTGS2	3-methylcholanthrene,AHR,ARNT,CEBPB,ESR1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD4,SP1,STAT3,TP53,TP73	
P1	 	TNFSF13B	0.278	cytokine	 	0.872	bias	0.331	-0.298	5.08E-03	ADIPOQ,BCL2L1,CCL2,CCND2,CD86,CDK4,CXCL8,DUSP5,LEP,MCL1,MMP9,MYC,SPP1,TFG	Akt,ERK1/2,HIF1A,IL2,JUN,Mek,NFKB1,NFKB2,NFKBIA,NFkB (complex),NR3C1,RELA,SMAD3,SRF,STAT1,STAT3,TNFSF13B,TP53	
P1	 	anisomycin	 	chemical - endogenous non-mammalian	Inhibited	-2.650	 	0.191	-3.269	5.08E-03	ATF3,BCL2L1,CXCL8,DUSP1,EGR1,FOS,HSPA5,IL6,JUN,JUNB,LDLR,MCL1,PLAUR,SPP1	ATF2,ELK1,ERK1/2,FOS,JUN,MAP3K1,MAPK3,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT3,anisomycin	
P1	 	luteolin	 	chemical - endogenous non-mammalian	 	1.669	bias	-0.319	2.550	5.11E-03	BCL2L1,CDK4,FOS,GCLM,HMOX1,IL6,JUN,MMP2,MMP9,MYC,PTGS2,SELE,TNFRSF10B	Ap1,ERK,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SMAD3,SP1,STAT3,TNFSF10,luteolin,nitric oxide	
P1	 	SMAD5	-0.196	transcription regulator	 	-0.946	 	0.206	-1.441	5.16E-03	ALPL,BMP2,COCH,CSF2RA,CTGF,ID1,ID3,RUNX1,SMAD6	HIF1A,MYOCD,NOTCH1,RUNX2,SMAD3,SMAD5,VHL	
P1	 	anakinra	 	biologic drug	 	0.928	 	-0.188	1.382	5.16E-03	EDN1,GRINA,HMOX1,IL6,MAP2K3,PTGS2,SELE,VCAM1,VWA5A	Ap1,FOXO1,Growth hormone,HIF1A,IL1A,IL1B,IL1R1,IL6,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,STAT3,anakinra	
P1	 	bisindolylmaleimide	 	chemical - kinase inhibitor	 	0.121	bias	-0.386	1.244	5.16E-03	CTGF,CXCL8,EGR1,FGF2,FOS,GFPT1,IL6,ITGAM,MYC	Ap1,ELK1,ERK,ERK1/2,JUN,NFKBIA,NFkB (complex),P38 MAPK,PRKCB,RELA,SMAD3,STAT3,bisindolylmaleimide,nitric oxide	
P1	 	irbesartan	 	chemical drug	 	-0.332	bias	-0.251	0.313	5.16E-03	ADIPOQ,CCL2,CD36,FHL1,FOS,HRAS,LEP,SMAD6,VCAM1	Agtr1b,Ap1,HIF1A,JUN,NFKBIA,NFkB (complex),P38 MAPK,PPARG,PTGS2,RELA,STAT3,TP53,irbesartan,reactive oxygen species	
P1	 	ozone	 	chemical toxicant	 	-1.615	bias	0.501	 	5.16E-03	CCL3L3,CXCL2,CXCL8,FOS,HMOX1,IL6,JUN,JUNB,SPP1	Ap1,CEBPA,CEBPB,CSF3,IKBKB,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT3,ozone	
P1	 	ramipril	 	chemical drug	Inhibited	-2.345	bias	-0.381	-1.208	5.16E-03	COL1A1,COL1A2,COL3A1,COL4A5,CTGF,MMP2,MMP9,PTGS2,TIMP1	 	
P1	 	KIT	1.019	transmembrane receptor	 	0.254	 	0.125	0.010	5.30E-03	BCL2L1,BIRC7,CCND2,CCND3,CPA3,CXCR4,FCER1A,GPR34,HDC,HMOX1,IL6,KIT,MCL1,MTOR,MYC,PPP2R1A,RAB32,SHC1,SOCS2,SOCS3,SPP1,TJP1	Akt,Ap1,GATA1,HIF1A,JUN,KIT,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,SRC,STAT3,TNF,TP53,imatinib	
P1	 	zinc	 	chemical drug	 	-1.576	 	-0.060	-1.324	5.32E-03	AKR1B10,BLMH,CAT,CD86,CDK4,CNN1,COL1A1,ENO1,HMOX1,IL6,KPNA2,MAFG,MGP,MT1A,MT2A,NFKBIA,NGF,PTGS2,TFRC,TGM2	AKT1,CYP2E1,ERK1/2,FOXO1,IL1B,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TNF,TP53,zinc	
P1	 	TBX5	0.052	transcription regulator	 	-1.807	bias	0.340	-3.141	5.47E-03	ATP2A2,BCL2L1,CASQ2,CLSTN2,COL1A1,COL1A2,COL3A1,CXCL2,CXCL8,ECM2,HEY2,HSPB7,KCNJ2,LOC102724428/SIK1,PLA2G2A,PTPRB,TPM1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TBX5,TP53	
P1	 	RHOA	0.223	enzyme	 	-0.040	 	0.189	-0.756	5.69E-03	ACTA1,AGT,BCL2L1,COL1A1,COL3A1,CTGF,CTSD,CXCL8,ERBB2,ESR1,FOS,GDF15,IL6,JUN,MMP9,RHOB,SOX9,TAGLN,VCAM1	Akt,Ap1,EGF,ERK1/2,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RHOA,SMAD3,STAT3,TP53	
P1	 	USF1	-0.071	transcription regulator	 	-0.290	bias	0.412	-1.632	5.69E-03	AGT,AGTRAP,AKAP12,CAT,CBS/CBSL,CCNG2,CDK4,DUSP1,FCER1A,GPAM,IGF2R,IGFBP3,LDLR,POMC,PTGS2,SLC19A1,SPP1,TNFAIP3,UCP2	IRF8,JUN,NFKBIA,NFkB (complex),STAT1,STAT3,USF1	
P1	 	clozapine	 	chemical drug	 	-0.104	bias	0.293	-1.176	5.73E-03	ACACA,ACAT2,AXIN1,CIDEA,DHCR7,DVL3,EGR1,FOS,GSK3B,HMGCS1,IL6,LDLR,NR4A2,NR4A3,PEA15,SGK1	ADRA1B,ADRA1D,AKT1,CREB1,Creb,FOXO1,Growth hormone,HIF1A,Insulin,JUN,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,STAT3,TP53,clozapine,norepinephrine	
P1	 	BMP7	-0.173	growth factor	 	0.144	bias	0.266	-1.195	5.75E-03	ADIPOQ,ADORA1,ALDH1A2,BMP4,CCL2,CEBPD,CIDEA,COL1A1,COL1A2,CXCL8,EDN1,GRB14,HRAS,ID1,IGFBP3,IGFBP4,IGFBP6,IL6,KLF4,MMP2,NDRG1,POMC,SMAD6,SMAD7,SOCS3,SPP1,SULF1	Ap1,BMP7,ERK1/2,ESR1,GATA4,IL6,JUN,NFATC2,NFKBIA,NFkB (complex),NOTCH1,Nfat (family),RELA,RUNX2,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad	
P1	 	interferon beta-1a	 	biologic drug	 	-0.192	 	0.125	-0.440	5.75E-03	ARHGEF6,ATP5I,CD4,CHFR,CS,CSF1R,CXCR4,EEF1G,ENO1,FCER1G,FCGRT,FKBP1A,GADD45B,MMP9,MRPS18B,NCF2,NDUFB9,NFKBIA,NOTCH1,PIN1,PLAUR,RAE1,RAN,S100A9,SLC25A6,TBCB,TTC1	 	
P1	 	BSG	1.180	transporter	 	1.058	bias	0.294	0.152	5.76E-03	BCL2L1,BSG,CDH2,CXCL8,EPAS1,HIF1A,KDR,MMP2,MMP9,TJP1	APP,Akt,Ap1,BSG,CTNNB1,HIF1A,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),NOTCH1,PI3K (complex),RAC1,RELA,SP1,STAT1,STAT3,TP53	
P1	 	CGA	-0.014	other	 	-1.445	bias	0.309	-2.396	5.76E-03	ADAMTS1,BIRC3,CLDN5,CXCL8,LHCGR,MMP2,PARM1,PTGS2,SFRP4,SGK1	AR,CGA,CREB1,FOS,FSH,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PRL,RELA,RNA polymerase II,SMAD3,SP1,STAT1,STAT3,STAT5B,TP53,estrogen receptor	
P1	 	KNG1	0.012	other	 	-0.569	bias	0.294	-1.439	5.76E-03	ASIC1,COL1A1,COL1A2,CTGF,CXCL8,FGF2,FOS,IL6,KDR,PTGS2	Ap1,ETS1,HIF1A,JUN,KNG1,Mek,NFKB1,NFKBIA,NFkB (complex),RAC1,RELA,SMAD3,SMAD4,SRF,STAT1,STAT3,TP53,Tgf beta,VEGFA	
P1	 	prostaglandin J2	 	chemical - endogenous non-mammalian	 	0.953	bias	0.368	-0.169	5.76E-03	CXCL8,GDF15,HMOX1,HSPA1A/HSPA1B,IL6,MYH11,PSMA3,PSMB2,PSMB7,PTGS2	26s Proteasome,Akt,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TP53,prostaglandin A1,prostaglandin J2	
P1	 	NFYB	-0.088	transcription regulator	 	 	 	 	 	5.85E-03	ACLY,CAV1,CBS/CBSL,CBX5,CDH2,CHEK2,COL1A1,COL1A2,COL5A3,CYTIP,DNAJB6,EIF3C,EMC6,EMX2,EMX2OS,EPAS1,F8,FIZ1,FLCN,FLRT2,FRYL,FTH1,GADD45A,GAPDH,GPAM,GPR160,HSPA13,ICK,ITM2C,KCTD1,KIAA0930,LIG3,LPIN1,MSRA,NOSIP,NUDT2,PSMB7,PTTG1,RHOB,SH3GL1,SLC39A8,SLIT3,TAX1BP3,TGFBR2,THRSP,TJP1,TPM1,TXNDC12,VPS52,ZFP42,ZNF524	 	
P1	 	BMP15	0.118	growth factor	 	-0.723	 	0.137	-1.106	5.89E-03	CYP11A1,ID1,ID3,LHCGR,PTGS2,PTX3,SMAD6,SMAD7	Ap1,BMP15,BMP7,CREB1,FOS,FSH,GATA4,GDF9,JUN,NFkB (complex),NOTCH1,RUNX2,SMAD1,SMAD3,SMAD5,SP1,Smad	
P1	 	IND S1	 	chemical - kinase inhibitor	 	0.000	 	-0.046	0.129	5.89E-03	ATP5D,C1QBP,COPS8,ENO1,GLOD4,HSPA1A/HSPA1B,STIP1,TUBB	 	
P1	 	NFAT (complex)	 	complex	 	0.707	bias	0.442	-0.544	5.89E-03	ATF3,CCL2,CD68,CD86,CYGB,IL6,SLC1A3,SPP1	 	
P1	 	NTRK1	0.134	kinase	 	0.896	bias	0.430	-0.149	5.89E-03	DLG4,EGR1,FOS,GADD45A,MMP9,RET,SCRIB,TSC22D1	AKT1,BRAF,CREB1,ELK1,FOS,JUN,MAPK3,NFKB1,NFkB (complex),NFkB (family),NTRK1,Pkc(s),RELA,Ras,SP1,STAT1,STAT3,TP53	
P1	 	TET1	0.512	enzyme	 	-1.340	bias	0.351	-2.307	5.89E-03	EGR2,FOS,HOXA9,KLF2,KRT8,PBX3,SOX17,ZFP42	 	
P1	 	CXCR4	-0.784	g-protein coupled receptor	 	-1.617	bias	0.373	-2.975	5.97E-03	AXL,CCL2,CD69,CDH2,CXCL12,CXCL8,CXCR4,EGR1,ID1,IL6,JUNB,MMP2,MYC,TNFRSF10B,TNFSF10	Ap1,CEBPA,CEBPB,CXCL12,CXCR4,ERK1/2,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	PRKCB	-0.184	kinase	 	-0.115	bias	0.309	-1.254	5.97E-03	ACTA1,BCL2L1,CD86,CLCN7,EGR1,FGF2,FOS,IL6,IRS2,JUN,MMP2,MMP9,MYC,PTGS2,TGFBR2	Ap1,ERK1/2,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PRKCB,RAC1,RELA,SMAD3,STAT3,nitric oxide	
P1	 	GPD1	-0.064	enzyme	 	 	 	 	 	6.06E-03	ACLY,ALPL,ASNS,C6,CD36,CYP2C8,ELOVL3,ELOVL6,FADS3,FAM129A,FMO3,GADD45A,GBP4,MCM2,MTHFD1L,NOL3,NQO1,PFKFB3,PSAT1,RARRES1,SERPINA3,SERPINE2	 	
P1	 	NCSTN	0.665	peptidase	Inhibited	-2.111	bias	-0.279	-1.187	6.11E-03	CD14,CD68,CEBPD,CSF1R,CTSG,ELANE,FCER1G,GRN,NOTCH1,S100A1,SPI1	NCSTN,NFkB (complex),NOTCH1,RELA,SMAD3,STAT3,TP53	
P1	 	NEDD9	-0.710	other	 	0.905	bias	0.473	-0.664	6.11E-03	ADM,BMP2,DDIT4,FOS,GDF15,KIT,MKNK2,MMP9,PLIN2,STC1,TF	ARNT,Akt,ERK,HIF1A,IL2,JUN,MYC,NEDD9,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARG,PTK2,RELA,SMAD3,STAT1,STAT3,TP53,VHL	
P1	 	6-hydroxydopamine	 	chemical toxicant	Activated	2.686	 	0.227	1.766	6.14E-03	ATF4,BCL2L1,DDIT3,DDIT4,FOS,FOSB,GAP43,HSPA1A/HSPA1B,HSPA4,HSPA5,HSPA8,HSPA9,IL6,JUN,LONP1,MMP9,NR4A2,PSMB2,TRIB3,ZMAT3	6-hydroxydopamine,Ap1,CREB1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SNCA,STAT3,TP53	
P1	 	ATF2	-0.180	transcription regulator	 	-0.035	bias	0.481	-1.669	6.14E-03	ASNS,ATF3,CXCL8,DDIT3,DUSP1,DUSP10,EGR1,FOS,GADD45A,IL6,JUN,MCL1,MT2A,MYLK,NOTCH1,NUPR1,PLA2G4A,PTGS2,RHOB,VCAM1	ATF2,Ap1,ESR2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF	
P1	 	CFTR	-0.022	ion channel	 	0.036	 	-0.040	0.207	6.14E-03	ASNS,CA4,CAPG,CPA3,CUBN,CXCL8,FAAH,GSR,HSD17B11,NFKBIA,NFKBIZ,PLA2G5,POR,PTGS2,S100A8,SAA1,SLC7A8,SOCS3,SQLE,TNFAIP3	CFTR,HDAC2,HIF1A,Hsp70,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SIN3A,STAT1,STAT3,TP53	
P1	 	YY1	0.358	transcription regulator	 	1.508	 	0.040	1.356	6.15E-03	ACTA1,ALCAM,ATF4,BCL2L1,BMP4,BMP6,BTG2,CAPG,CDKN2C,COL15A1,COL1A1,CRABP1,CXCL12,CXCR4,DNAJB4,EBF2,ERBB2,FCER1A,FOS,GBP1,GPC3,HMOX1,HSPA5,ID4,KDR,KIF5B,LDLR,MMP2,MYC,MYH1,MYH11,MYOM1,NIPSNAP1,NNAT,ORM1,PAWR,PERP,PNRC2,PPP1R15A,PTPRA,RAD21,SRC,TAGLN,TGM2,TNFRSF4,UNG,VEGFC,WSB1	Ap1,CREBBP,EGR1,EP300,ESR1,HIF1A,MYC,NFkB (complex),NOTCH1,RELA,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,TP53,TP73,YY1	
P1	 	H2AFB3 (includes others)	0.075	other	 	-0.535	bias	0.501	 	6.15E-03	ATF3,ATF5,CDKN1C,CHAC1,CLCNKA,DCLK1,DHRS9,FOS,ING1,IRF3,PCDH9,PRPH,SAA1,SAA2	H2AFB3 (includes others),HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P1	 	inosine	 	chemical - endogenous mammalian	Activated	3.705	bias	0.383	2.284	6.15E-03	ALCAM,ANXA5,C1QA,C1QB,C1QC,C2,CCL3L3,CD68,CFB,EIF4EBP1,EMP3,GAP43,PPP1R14B,TIMP1	 	
P1	 	(5-(4-N-methyl-N(2-pyridyl)amino)ethoxy)benzyl thiazolidine-2,4-dione	 	chemical reagent	 	0.351	bias	0.301	-0.318	6.15E-03	CIDEC,COL1A1,ITGAM,PC,SLC27A1	 	
P1	 	6-mercaptopurine	 	chemical drug	 	0.447	bias	-0.301	1.120	6.15E-03	CXCL8,IL6,NR4A3,TNFSF10,VCAM1	6-mercaptopurine,ATF2,Ap1,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NR4A1,RAC1,RELA,RXRA,SP1,STAT3,TP53	
P1	 	MIR320	 	group	 	0.152	bias	-0.501	 	6.15E-03	EDN1,EMILIN2,ETS2,MMP9,TFRC	 	
P1	 	RPS6KA3	-0.070	kinase	 	-0.386	bias	0.390	-1.236	6.15E-03	FOS,FSCN1,LEP,MYC,TNFRSF10B	AKT1,CREBBP,CTNNB1,Creb,ELK1,EP300,ERK,ERK1/2,FOS,JUN,MAPK3,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RPS6KA3,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	RPS6KA4	0.538	kinase	 	-1.412	 	0.000	-1.412	6.15E-03	DUSP1,FOS,IL6,JUN,JUNB	CEBPB,CREB1,CREBBP,CREM,CTNNB1,Creb,EP300,IL10,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RPS6KA4,SP1,STAT1,STAT3,TP53	
P1	 	S-equol	 	chemical drug	 	 	 	 	 	6.15E-03	CD86,IL6,MMP2,MMP9,PLAT	Akt,Ap1,HIF1A,JUN,NFkB (complex),RELA,S-equol,SP1,STAT3,TP53,estrogen receptor	
P1	 	Shc	 	group	 	0.554	 	0.201	0.109	6.15E-03	BCL2L1,CCND2,CCND3,FOS,MYC	Akt,Ap1,ERK,HIF1A,HRAS,JUN,NFkB (complex),PI3K (complex),RELA,Ras,SMAD3,SP1,STAT1,STAT3,Shc,TP53	
P1	 	beraprost	 	chemical drug	 	0.447	 	-0.201	0.896	6.15E-03	CCL2,CD86,COL1A1,COL3A1,EDN1	 	
P1	 	edaravone	 	chemical drug	 	0.391	bias	-0.501	 	6.15E-03	CCL2,DDIT3,HSPA5,IL6,PTGS2	Ap1,CEBPA,CEBPB,CTNNB1,HDAC1,IL6,JUN,Jnk,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,RELA,SP1,STAT1,STAT3,TP53,Vegf,edaravone	
P1	 	tridecanoic acid	 	chemical - endogenous mammalian	 	-1.342	bias	0.501	 	6.15E-03	CD59,CDKN1C,DDIT3,DUSP5,KLF4	 	
P1	 	herbimycin	 	chemical - kinase inhibitor	 	0.659	bias	-0.305	1.739	6.26E-03	BCL2L1,CCND3,CDK4,CTGF,CXCL8,CXCR4,DUSP1,FOS,IL6,JUNB,MMP2,MMP9,PTGS2	ATF2,Akt,CREB1,EGFR,ERK,ERK1/2,FOS,HIF1A,JUN,NFKBIA,NFkB (complex),Pkc(s),RELA,SMAD3,SP1,STAT3,TP53,herbimycin	
P1	 	S-nitrosoglutathione	 	chemical toxicant	 	-0.238	 	-0.079	0.019	6.26E-03	BCL2L1,BIRC3,CCL2,CD86,HIF1A,IRS2,ITGAM,NFKBIA,NQO1,PTGS2,SELE,VCAM1	AKT1,Ap1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,S-nitrosoglutathione,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	T3-TR-RXR	 	complex	 	1.673	bias	0.404	0.287	6.26E-03	ACACA,AKR1C3,COL6A3,ENO1,HP,KLF9,LDLR,ME1,PDE3B,RCAN2,THRSP,UCP2	 	
P1	 	nonylphenol	 	chemical toxicant	 	0.653	bias	0.404	-0.740	6.26E-03	ADIPOQ,ALDH5A1,APEH,APOB,ATP6AP1,CCL2,ESR1,HSPA1A/HSPA1B,LBP,PTGS2,RPN2,SLC1A5	AR,Akt,Creb,ESR1,FOS,HIF1A,JUN,MAPK1,NFkB (complex),SP1,STAT1,STAT3,TP53,nonylphenol,testosterone	
P1	 	CYP1A1	-0.091	enzyme	 	-0.522	 	0.040	-0.641	6.36E-03	ANXA3,AP2M1,BANF1,CACHD1,CNN2,DNAL4,GAMT,GPC1,GSTM2,GSTM3,KIF2A,LMNA,MARCO,MYO10,NDUFV1,NQO1,ODC1,PRPH,RGS16,SOCS2,ST3GAL4,TRPM8,TSC22D1	 	
P1	 	TBP	0.093	transcription regulator	 	 	 	 	 	6.43E-03	ALAS2,ASNS,COL1A1,EDNRA,ETS2,FOS,GAPDH,HOXA9,IER3,LDLR,MEOX2,MYC,NFKBIA,PTGS2,RN7SK,RPL34,TNFAIP3	Ap1,EP300,ESR1,ESR2,JUN,NFKB1,NFkB (complex),NR3C1,PGR,RELA,RNA polymerase II,Ras,SP1,STAT1,STAT3,TBP,TP53,estrogen receptor	
P1	 	Ctbp	 	group	 	-0.391	 	0.084	-0.576	6.50E-03	ADRB2,CTSK,DSG2,GADD45A,HEY1,PERP,PLAUR	Ctbp,MYC,NFkB (complex),SP1,STAT3,TP53,TP73	
P1	 	GPER1	-0.356	g-protein coupled receptor	 	-1.903	bias	0.383	-2.879	6.50E-03	CTGF,EGR1,ESR1,FOS,HSPA5,MYC,SFRP2	CEBPB,ELK1,ERK1/2,ESR1,ESR2,FOS,GPER1,JUN,MAP2K1,MAPK1,MAPK3,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,beta-estradiol	
P1	 	NPC2	0.367	other	 	1.276	bias	-0.501	 	6.50E-03	AKR1C3,BMP2,CREB5,PLA2G4A,PTGDS,PTGER4,PTGS2	IL6,JUN,NFkB (complex),NPC2,RELA,SP1,STAT1,STAT3,prostaglandin E2	
P1	 	TMSB4	 	group	 	-0.160	bias	0.390	-1.177	6.50E-03	BMP2,BMP4,IRAK1,ITGA1,ITGA3,MBP,SPP1	ELK1,FOS,JUN,MAPK3,NFkB (complex),STAT3,TMSB4	
P1	 	thiazolidinedione	 	chemical drug	 	-1.709	bias	0.301	-2.429	6.50E-03	ABCG1,ADIPOQ,IRS2,NR4A2,NR4A3,SORBS1,UCP2	D-glucose,FOXO1,Growth hormone,HIF1A,Insulin,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,TNF,fatty acid,thiazolidinedione	
P1	 	MIF	0.918	cytokine	 	-0.636	 	0.247	-1.635	6.59E-03	ATF5,CCL2,CCL3L3,CDC34,COL1A1,CXCL2,CXCL8,DGAT2,DUSP1,FOS,IL6,JUN,MMP2,MMP9,MYCN,PTGS2,RAMP2,TIMP1,VCAM1	Ap1,CEBPB,ERK1/2,ESR1,IL17A,JUN,Jnk,MIF,NFATC2,NFKB1,NFKB2,NFKBIA,NFkB (complex),Nfat (family),PRKCD,RELA,SMAD3,STAT3	
P1	 	rottlerin	 	chemical toxicant	 	0.212	bias	-0.420	1.975	6.59E-03	BIRC3,CCND3,CDK4,COL1A1,COL3A1,CXCL8,DDIT3,HMOX1,JUN,MMP2,MMP9,PDCD4,PRKCD,PTGS2,TJP1,TJP2,TNFRSF10B,VCAM1,ZFP36	Akt,Ap1,ERK,HIF1A,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),P38 MAPK,PRKCD,RELA,SMAD3,STAT3,TP53,rottlerin	
P1	 	BMP4	-0.580	growth factor	 	-0.901	bias	0.251	-2.079	6.70E-03	ALDH1A2,ASIP,BMP2,BMP4,CNN1,COCH,CYR61,HEY1,ID1,ID3,IL6,JUN,JUNB,KDR,KIT,KLF4,MYC,MYCN,PYCR2,RET,SMAD6,SMAD7,SOX9,SPARC,SPI1,SULF1,TAGLN,TGM2,ZFP42	BMP4,ERK1/2,ESR1,ESR2,GATA4,NFKBIA,NFkB (complex),NOTCH1,RELA,RUNX2,SMAD1,SMAD3,SMAD4,SMAD5,SP1,STAT3,Smad,beta-estradiol	
P1	 	IL7	-0.063	cytokine	 	0.086	bias	0.303	-1.419	6.70E-03	BCL2L1,CCL2,CCL3,CCND2,CCND3,CD69,CD86,COL1A1,CTSK,CXCR4,DUSP5,EBF1,GARS,GSR,HAVCR2,HCST,IL18RAP,IL6,KLF2,LYN,MAF,MCL1,MMP9,MYC,RGS16,SMAD7,SOCS3,TNFSF10,UPP1	Ap1,IL15,IL2,IL4,IL7,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PI3K (complex),RELA,SP1,STAT1,STAT3,STAT6	
P1	 	GAB1	0.059	kinase	 	-0.881	bias	0.358	-1.739	6.75E-03	ANGPT1,EGR1,EGR2,ELK1,HRAS,IL6	Akt,Ap1,CEBPB,FOS,GAB1,HIF1A,HRAS,JUN,MAP2K1,MAPK8,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53	
P1	 	GTF2I	0.177	transcription regulator	 	-1.109	bias	0.358	-1.820	6.75E-03	CAT,FOS,HSPA5,KDR,MYC,THBS1	GTF2I,HIF1A,JUN,MAX,MYC,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P1	 	IL2RB	0.294	transmembrane receptor	 	-1.746	bias	0.287	-2.434	6.75E-03	CCL2,CCND3,ETS1,FOS,JUN,MYC	HRAS,IL2,IL2RB,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PTPN11,RELA,SP1,SPI1,STAT1,STAT3,STAT5a/b,STAT6,TP53	
P1	 	Srebp	 	group	 	1.673	bias	0.501	 	6.75E-03	ACLY,FOS,G6PD,LDLR,PGD,UCP2	 	
P1	 	diacylglycerol	 	chemical - endogenous mammalian	 	0.000	bias	0.501	 	6.75E-03	ACADM,CD36,ODC1,PRKCD,PRKCE,UCP2	ATF2,CREB1,FOS,INSR,JUN,NFKB1,NFkB (complex),PDX1,PPARA,PPARG,PRKCE,RELA,SREBF1,STAT1,STAT3,STAT5a/b,arachidonic acid,diacylglycerol	
P1	 	gambogic acid	 	chemical - endogenous non-mammalian	 	0.277	bias	-0.424	1.219	6.75E-03	BCL2L1,BIRC3,MCL1,MMP9,MYC,PTGS2	Akt,Ap1,ERK,HDAC3,HIF1A,IKK (complex),JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3,TP53,gambogic acid	
P1	 	nystatin	 	chemical drug	 	-0.277	bias	0.410	-1.074	6.75E-03	CCL3L3,CD86,CXCL8,IL6,SPP1,TIMP1	Ap1,ERK1/2,JUN,Jnk,NFATC2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TLR4,nystatin	
P1	 	onapristone	 	chemical drug	 	0.447	bias	-0.334	1.195	6.75E-03	ADAMTS1,CTSD,ESR1,HBEGF,PMP22,RUNX1	NFkB (complex),NR3C1,PGR,RNA polymerase II,STAT3,estrogen receptor,onapristone	
P1	 	ASAH1	-0.165	enzyme	 	-0.862	bias	-0.279	-0.035	6.83E-03	CERS6,CYP11A1,ETS1,LIPE,NR4A2,NR4A3,SMPD1,SPHK2,SPTLC2	ASAH1,NFkB (complex),PPARA,PPARD,PPARG,SREBF1,fatty acid	
P1	 	DRD2	0.070	g-protein coupled receptor	 	0.086	 	-0.022	0.143	6.83E-03	CCL2,FOS,FOSB,IGFBP3,JUN,KCNJ2,NAT8L,POMC,TGFBR2	CEBPB,CREB1,DRD2,ERK1/2,FOS,FOXO1,Growth hormone,HIF1A,IL1B,Insulin,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,STAT1,STAT3,cyclic AMP	
P1	 	THBS4	-1.918	other	 	1.540	 	0.204	0.940	6.83E-03	ATF4,ATF6,COL3A1,HSPA5,HYOU1,MTHFD2,SDF2L1,SELE,VCAM1	 	
P1	 	everolimus	 	chemical drug	 	-1.964	 	-0.196	-1.450	6.83E-03	CAV1,CCND2,CCND3,CTGF,FSCN1,KDR,MCL1,MMP2,MYC	ATF2,Akt,EGFR,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT3,TP53,everolimus	
P1	 	vitamin K3	 	chemical drug	 	0.508	bias	0.421	-0.725	6.83E-03	ABCC1,BMP6,DDIT3,EGR1,FOS,HMOX1,HSPA5,MYC,PPRC1	ATF6,Ap1,Creb,DDIT3,EGR1,FOS,FOSL1,FOXO1,FOXO3,JUN,Jnk,MAP2K1/2,MAPK8,MXI1,NFkB (complex),RELA,SMAD3,STAT3,TP53,vitamin K3	
P1	 	thyroid hormone	 	chemical - endogenous mammalian	 	0.417	 	-0.013	0.478	6.92E-03	ABCG1,ACTA1,AGT,AK4,ALAS2,APOE,ATF4,ATP2A2,BTG2,CDKN2B,COMT,CRAT,EGR1,FOS,G6PD,GDI1,ID1,IGFBP3,IGFBP4,KLF9,LEP,MBP,ME1,MYC,NNAT,PGD,PLA2G2A,PLA2G5,PTGDS,RAD21,RELN,RTN1,SERPINE2,TCEA3,THRSP,UCP2,UQCR10	ATF2,Ap1,ESR1,ESR2,JUN,LEP,NCOR2,NFKB1,NFKBIA,NFkB (complex),PPARG,PRKCA,RELA,RNA polymerase II,RXRA,SP1,STAT3,THRB,TSH,thyroid hormone	
P1	 	NKX2-1	0.063	transcription regulator	 	0.371	 	0.228	-0.306	6.95E-03	ADGRF5,AGT,BTG3,CA4,CD14,CDKN2B,CYGB,ENPP2,EPHB3,ESAM,HS2ST1,IER3,IGFBP6,LMO3,LSP1,LYZ,MIA,MMP2,MTUS1,MYH11,PC,QSOX1,RET,RNASE4,ROR1,SCARA3,SFTPD,SH3PXD2A,SMAD7,SOX17,TFF3,THBS1,THY1,TMEM37,TPO,WNT5B	 	
P1	 	NFKB2	0.210	transcription regulator	 	-0.363	bias	0.281	-1.350	7.11E-03	AKR1B1,BCL2L1,BIRC3,BMP2,CD86,CXCL12,CXCL8,CXCR4,FOS,MMP2,MMP9,MYC,PTGS2,STIM1,VCAM1	HIF1A,IL10,IL2,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),NR3C1,RELA,STAT1,STAT3,TP53	
P1	 	SIRT1	-0.437	transcription regulator	 	-1.671	 	0.026	-1.818	7.15E-03	ABCG1,ACADM,ADIPOQ,BCL2L1,BIRC3,CAT,CCND2,CCNG2,CDH2,CDKN2B,DBP,DDAH2,EDEM1,EIF2S2,ESR1,GABARAPL1,GADD45A,H2AFZ,HMOX1,ID1,IL6,KIF1A,KLF2,LEP,MAOA,MMP2,MMP9,MTHFD1L,MYC,MYL6B,NEDD4L,NLGN1,NR1D1,PC,PCK2,PDK4,RGS16,SEC61A1,SFRP2,SFRP4,THBD,TNFRSF10B,UCP2	AR,ATF4,Ap1,CEBPA,CEBPB,E2F1,EGR1,FOXO1,FOXO3,HIF1A,JUN,MXI1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,RELA,SIRT1,SP1,STAT1,STAT3,TP53,reactive oxygen species	
P1	 	KDM5A	-0.151	transcription regulator	Inhibited	-4.536	bias	-0.440	-2.209	7.34E-03	ACO2,ATP6V1D,ATP6V1F,CD55,COA3,COL1A2,COX17,GADD45GIP1,GHITM,HMOX1,ICT1,MAP2K3,MCM2,MRPL12,MRPL17,MRPL55,MTOR,MYL6B,MYOM2,NDUFA10,NDUFA13,NDUFA9,NDUFB10,NDUFS7,NDUFV1,NME1,PGD,UQCRC1	 	
P1	 	GNAQ	0.178	enzyme	 	-1.770	bias	0.376	-2.681	7.39E-03	ACTA1,ADAMTS1,ATP2A2,BNIP3L,CXCL8,FOS,GNA11,PRKCD,PRKCE,PTGS2	Ap1,CREB1,CREBBP,EGR1,GNAQ,JUN,Lh,MAP2K3,MAP2K5,MAP2K6,MEF2C,NFE2L2,NFKB1,NFkB (complex),PRKCE,RELA,STAT1,STAT5B,TP53	
P1	 	NKX3-1	-0.309	transcription regulator	 	 	 	 	 	7.39E-03	BTG2,CA12,CA3,CTSB,ETS1,FOS,IGFBP3,MMP23B,MMP9,MYC,PTPRK,RUNX1,SDC4,VAV3	Akt,Ap1,ERK1/2,FOSL1,GSK3B,HIF1A,JUN,MAP2K1/2,NFKB1,NFKBIA,NFkB (complex),NKX3-1,P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	NR4A3	-0.963	ligand-dependent nuclear receptor	 	-1.097	 	0.211	-1.847	7.39E-03	BIRC3,CCND2,COL16A1,COL1A1,COL6A1,COL6A2,FBP1,HIF1A,LPIN1,MYH1,NQO1,POMC,SLC39A8,UCP2	FOXO1,Growth hormone,HIF1A,Insulin,NFKB1,NFKBIA,NFkB (complex),NR4A3,PPARA,PPARG,RELA,STAT3,TNF	
P1	 	AGTR1	0.160	g-protein coupled receptor	 	0.870	 	0.167	0.434	7.66E-03	AGT,COL3A1,CYBA,DUSP1,EDN1,FOS,GSTM5,HMOX1,IL6,JUN,PTGS2	AGTR1,ATF2,Ap1,FOS,HIF1A,JUN,Jnk,MAP3K1,NFKB1,NFKBIA,NFkB (complex),NR3C1,NR3C2,RELA,SMAD3,SMAD7,STAT3,aldosterone,losartan potassium	
P1	 	PTPN6	0.375	phosphatase	 	-1.304	 	-0.243	-0.551	7.66E-03	BCL2L1,CD86,CDK4,CXCL8,ETS1,IL6,LYN,MYC,NCF2,POMC,TIMP1	Ap1,ERK,ERK1/2,IL2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR3C1,PTPN6,RELA,SMAD3,STAT1,STAT3,TNF	
P1	 	TYROBP	0.555	transmembrane receptor	 	-0.798	bias	0.313	-1.619	7.71E-03	CCL2,CCL3,CD69,CD86,CXCL8,IDO1,IL6,ITGAM,NCKAP1L,SLC1A5,SPP1,TYROBP	CREB1,CSF2,ELK1,FOS,IL1B,IRF8,JUN,MAPK3,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TYROBP	
P1	 	SLC25A13	0.644	transporter	 	 	 	 	 	7.84E-03	ACLY,ALPL,ASNS,C6,CD36,CYP2C8,ELOVL3,ELOVL6,FADS3,FAM129A,FMO3,GADD45A,GBP4,MCM2,MTHFD1L,NOL3,NQO1,PFKFB3,PSAT1,RARRES1,SERPINA3,SERPINE2	 	
P1	 	JAK2	0.027	kinase	Inhibited	-2.867	bias	0.413	-4.546	7.89E-03	ACTN1,AKR1C3,BCL2L1,CCL2,CCND2,CD36,CDC42BPB,CXCL8,DCXR,EGR1,ESR1,FGF2,FOS,IL6,LY6E,LYN,MYC,ODC1,PFN1,PHLDA3,PTGS2,RARA,SLC11A1,SLC1A3,SOCS3,THBS1	Akt,ERK,ERK1/2,HIF1A,IRF8,JAK2,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,STAT1,STAT3,TP53	
P1	 	BSCL2	0.846	other	 	 	 	 	 	7.98E-03	ADIPOQ,AKR1C3,AOC3,CD36,CIDEC,CLEC10A,HMGA1,IER3,IL6,LEP,LPIN1,NAT8L,PC,PTGS2,THRSP,TIMP1	BSCL2,ESR1,PPARG,PPARGC1A,SREBF1,SREBF2,USF1	
P1	 	9Z,11E-octadecadienoic acid	 	chemical - endogenous non-mammalian	Activated	2.137	 	-0.022	2.198	7.98E-03	CD36,EBF1,IL10RA,LDLR,PTGS2,SORBS1,THBS1,UCP2	9Z,11E-octadecadienoic acid,Ap1,ERK,FOXO1,JUN,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SMAD3,SREBF1,STAT3,fatty acid	
P1	 	CX3CL1	-0.141	cytokine	 	1.890	bias	0.310	1.069	7.98E-03	BCL2L1,FGF2,HIF1A,HMOX1,IL6,MMP2,MMP9,TIMP1	AKT1,Ap1,BCL2,CX3CL1,ERK,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RAC1,RELA,SMAD3,SP1,STAT1,STAT3,TP53	
P1	 	FAM3B	0.070	cytokine	 	 	 	 	 	7.98E-03	CASP4,CAV1,DAPK2,IER3,IGFBP3,IGFBP4,RNASE1,SPARC	CEBPA,CEBPB,FAM3B,FOS,Ins1,PPARA,PPARG	
P1	 	lipoarabinomannan	 	chemical - endogenous non-mammalian	 	-1.151	bias	0.410	-2.297	7.98E-03	CCL3,CD14,CXCL2,CXCL8,CXCR4,IER3,ITGA7,SELE	CEBPA,CEBPB,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT1,STAT3,TNF,lipoarabinomannan	
P1	 	STAT5a/b	 	group	 	-1.625	bias	0.386	-2.986	8.10E-03	BCL2L1,BMP6,CCND2,CD36,CD69,CDKN2C,DUSP1,EBF1,EMP1,FCER1G,FOS,GYPE,LEPR,MAF,MMD,MYC,PTGS2,RARA,SLC2A3,STIP1	Akt,Ap1,ERK1/2,FOS,HIF1A,IL10,JAK2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,STAT5a/b,TP53	
P1	 	haloperidol	 	chemical drug	 	-1.322	bias	0.279	-2.469	8.10E-03	AXIN1,CCND3,DLG4,DVL3,EGR1,FGF2,FOS,FOSB,GSK3B,HMGCS1,LDLR,LXN,NR4A2,NR4A3,POMC,PPP1R1B,PRKCE,SIGMAR1,SPRY2,SYN2	AKT1,CEBPB,CREB1,CREBBP,CREM,Creb,FOS,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),Pka,Pkc(s),RELA,SP1,STAT1,STAT3,TP53,haloperidol	
P1	 	RAC1	0.097	enzyme	 	0.482	bias	0.334	-0.913	8.15E-03	ACP5,AGT,ATF3,CD86,CDH2,COL1A2,CTGF,DUSP1,ESR1,FGF2,FOS,HIF1A,HMOX1,IL6,JUN,MMP2,MMP9,MYC,PLAUR,PTGS2,SHC1,SOX9,VCAM1	Ap1,ERK1/2,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RAC1,RELA,SMAD3,SP1,SRC,STAT3	
P1	 	2-mercaptoethanol	 	chemical - endogenous mammalian	 	0.152	 	0.215	-0.274	8.16E-03	ATF3,HMOX1,HSPA5,IDO1	2-mercaptoethanol,APP,Ap1,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,homocysteine	
P1	 	4-coumaric acid	 	chemical - endogenous mammalian	 	 	 	 	 	8.16E-03	FGF2,MYC,ODC1,PTGS2	 	
P1	 	DGAT2	0.615	enzyme	 	1.067	 	0.215	0.641	8.16E-03	ACACA,DGAT2,GPAM,UCP2	DGAT2,NFkB (complex),PPARA,PPARD,PPARG,SREBF1,fatty acid	
P1	 	EWSR1	0.055	other	 	 	 	 	 	8.16E-03	ABL1,CHEK2,ERBB2,FOS	 	
P1	 	GNE	-0.035	kinase	Inhibited	-2.000	 	-0.215	-1.570	8.16E-03	ASNS,CHAC1,DDIT3,TRIB3	 	
P1	 	HS6ST1	-0.056	enzyme	 	-0.116	bias	0.334	-0.774	8.16E-03	CXCL8,FGF2,IL6,TPSAB1/TPSB2	CREBBP,ERK1/2,FGFR1,HS6ST1,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,STAT1,STAT3,estrogen receptor	
P1	 	IGFBP4	1.947	other	 	0.750	 	-0.215	1.168	8.16E-03	IGFBP3,IGFBP6,MCAM,MYH11	CEBPB,HIF1A,IGF1,IGFBP4,JUN,SMAD3,SP1	
P1	 	KCNMA1	0.847	ion channel	 	0.000	 	0.215	-0.430	8.16E-03	CXCL8,KCNMA1,MMP2,POMC	 	
P1	 	MIB1	-0.023	enzyme	 	-1.965	bias	0.358	-2.669	8.16E-03	HEY1,HEY2,HEYL,NOTCH1	 	
P1	 	MLLT3	-0.018	other	 	 	 	 	 	8.16E-03	EDN1,HOXA9,MYC,SGK1	 	
P1	 	MS4A1	-0.098	other	 	 	 	 	 	8.16E-03	CD69,CD86,MCL1,MYC	ERK1/2,MS4A1,NFKBIA,NFkB (complex),RELA,SMAD3,STAT3	
P1	 	MTBP	0.003	other	 	 	 	 	 	8.16E-03	CCND2,CDKN2B,NCL,ODC1	 	
P1	 	MYCBP	-0.060	transcription regulator	Activated	2.000	bias	0.501	 	8.16E-03	CCND2,CDK4,NCL,ODC1	 	
P1	 	Muscarinic cholinergic receptor	 	group	 	-0.837	bias	0.501	 	8.16E-03	ALPL,CYR61,FOS,JUN	Ap1,CREB1,Ca2+,ERK1/2,ESR1,JUN,Muscarinic cholinergic receptor,NFATC2,NFKBIA,NFkB (complex),Nfat (family),PI3K (complex),RELA,SMAD3,SP1,STAT3,TP53,nitric oxide	
P1	 	PPP1CA	0.191	phosphatase	 	1.000	bias	0.358	0.284	8.16E-03	CDH2,CTGF,FOS,SPP1	AKT1,Akt,ELK1,FOS,HIF1A,JUN,MAPK1,MAPK3,NFKB1,NFkB (complex),PPP1CA,SP1,STAT1,STAT3,TP53	
P1	 	PPP5C	-0.120	phosphatase	 	0.000	 	-0.072	0.143	8.16E-03	CD36,DUSP1,PLIN1,SGK1	Ap1,ERK1/2,FOS,FOXO1,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,PPP5C,RELA,RXRA,SMAD3,SP1,STAT3	
P1	 	R59949	 	chemical - kinase inhibitor	 	1.000	bias	-0.501	 	8.16E-03	CCND3,CXCL8,FOS,MYC	AKT1,ARNT,Ap1,CREB1,Ca2+,FOXO1,Growth hormone,HIF1A,Insulin,JUN,MYC,NFKB1,NFkB (complex),PPARA,PPARG,PRKCA,R59949,RELA,SP1,STAT1,STAT3,TP53,VHL	
P1	 	RBCK1	1.033	transcription regulator	 	-1.067	bias	0.501	 	8.16E-03	ESR1,MYC,TNFAIP3,VCAM1	HDAC3,HIF1A,IKK (complex),JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RBCK1,RELA,STAT3,TP53	
P1	 	SLC25A4	0.204	transporter	 	-0.152	bias	-0.501	 	8.16E-03	ARL2,BCL2L1,BIRC3,MCL1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SLC25A4,STAT3	
P1	 	TMPO	-0.138	other	 	1.000	bias	0.501	 	8.16E-03	COL11A1,COL12A1,COL1A1,COL3A1	 	
P1	 	WP1066	 	chemical drug	 	0.371	 	-0.215	0.792	8.16E-03	CD86,EDN1,HIF1A,PSMB5	CEBPA,CEBPB,IL15,IRF8,JUN,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TP53,WP1066	
P1	 	manidipine	 	chemical drug	 	1.445	bias	-0.358	2.125	8.16E-03	CXCL8,FOS,IL6,JUN	JUN,NFKB1,NFKB2,NFkB (complex),PRKCD,PRKCE,RELA,STAT1,manidipine	
P1	 	polyphosphate	 	chemical - endogenous mammalian	 	0.107	bias	0.501	 	8.16E-03	BMP2,SELE,SPP1,VCAM1	FGF2,Fgfr,HDAC1,Hdac,Histone h4,JUN,NFkB (complex),NR3C1,RELA,SP1,STAT,STAT1,STAT3,TP53,polyphosphate	
P1	 	sanguinarine	 	chemical - endogenous non-mammalian	 	 	 	 	 	8.16E-03	CCL2,HMOX1,NQO1,TIMP1	AMPK,Ap1,CEBPA,CEBPB,ERK,ESR1,FOXO1,JUN,NFATC2,NFKB1,NFKBIA,NFkB (complex),Nfat (family),PPARGC1A,RELA,SMAD3,STAT1,STAT3,TP53,sanguinarine	
P1	 	TERT	0.066	enzyme	 	-0.599	 	0.179	-1.059	8.17E-03	ALDH1A3,ASNS,ATF3,CAV1,CD24,COL5A2,CTGF,CXCL8,ETS1,FGF2,GLB1,IFIT2,IGFBP4,IL6,LIPG,MMP2,MMP9,MTHFD1L,MYC,NFKBIA,NSFL1C,PLTP,PRSS23,PTGS2,SPON1,SPP1,TOX2,UBASH3B	CTNNB1,HDAC1,HDAC2,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,RNA polymerase II,SIN3A,SP1,SRC,STAT3,TERT,TP53	
P1	 	IL6ST	-0.413	transmembrane receptor	 	-1.970	bias	0.331	-3.003	8.43E-03	ATP2A2,BCL2L1,CSF1R,EGR1,HP,IL6,JUN,JUNB,MAF,MYC,NOTCH1,ORM1,RET,SOCS3,VCAM1	CEBPA,CEBPB,CEBPD,IL6,IL6ST,IRF8,JUN,LIF,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT,STAT1,STAT3,TP53	
P1	 	SAMSN1	0.088	other	 	-1.528	bias	0.446	-3.573	8.52E-03	CCL3L3,CCND2,CXCL2,DAB2,EDN1,FCER2,HBEGF,HDC,IFIT2,IL6,ISG20,LMO4,MARCO,NFKBIZ,PELI1,PLAT,PTGS2,RGCC,RILPL1,SOCS3,TSC22D1	Akt,HIF1A,IL4,JUN,NFkB (complex),RELA,SAMSN1,STAT1,STAT3,STAT6,TP53	
P1	 	HDAC4	0.079	transcription regulator	Activated	2.540	 	-0.046	2.681	8.64E-03	ACTA1,ANGPTL4,ATF3,C1QC,CHN1,FOS,FST,GADD45A,HIF1A,HOMER2,IL6,KLF2,MMP9,NBEA,NR4A2,NTM,PTGS2,RTN1,SYN1,SYN2,TAGLN,TNFRSF12A,TP53BP1,TSPAN13,VCAM1	Ap1,EP300,ESR1,HDAC1,HDAC3,HDAC4,Hdac,Histone h3,Histone h4,IRF8,JUN,NFATC2,NFKBIA,NFkB (complex),Nfat (family),RELA,RNA polymerase II,SP1,STAT1,STAT3,TP53,romidepsin	
P1	 	MAP2K3	0.567	kinase	 	-0.611	bias	0.440	-1.904	8.76E-03	ACTA1,ARG2,ATP2A2,CCL8,COL1A1,COL1A2,COL3A1,CTSK,CXCL8,DDIT3,IL6,MMP9,PTGS2,RAB34,SGK1,SLC1A3,TNFSF10	AR,EGR1,ERK1/2,IL10,JUN,MAP2K3,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SIRT1,SMAD3,SP1,STAT1,STAT3,TNF	
P1	 	NOD2	0.156	other	Inhibited	-2.051	bias	0.438	-3.659	8.76E-03	ALDH1A2,AXIN2,BMP2,CCL2,CCL3,CXCL2,CXCL8,IER3,IL6,ITGAM,KLF2,LMO4,MAP3K8,NFKBIA,SLC2A6,SOCS3,TNFAIP3	C5,Creb,HIF1A,IL1B,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),NOD2,RELA,STAT3,Tnf (family)	
P1	 	1-methyl-2-pyrrolidinone	 	chemical toxicant	 	 	 	 	 	8.76E-03	CTSK,FOS,MMP9	 	
P1	 	4-methylcatechol	 	chemical - endogenous mammalian	 	 	 	 	 	8.76E-03	HMOX1,JUN,NGF	 	
P1	 	ATF6B	0.094	transcription regulator	 	 	 	 	 	8.76E-03	DDIT3,HSPA5,RCAN1	ATF6,ATF6B,Creb,DDIT3,NFkB (complex)	
P1	 	ATP2A1	0.067	transporter	 	 	 	 	 	8.76E-03	ATP2A2,DDIT3,HSPA5	ATP2A1,CREB1,Ca2+,NFkB (complex),SP1,STAT3,TP53	
P1	 	BBS12	0.064	other	 	 	 	 	 	8.76E-03	ADIPOQ,IL6,LEP	 	
P1	 	CC8490	 	chemical drug	 	 	 	 	 	8.76E-03	CXCL8,IER3,IL6	CC8490,ESR1,ESR2,JUN,NFKB1,NFkB (complex),SP1	
P1	 	CMA1	0.280	peptidase	 	 	 	 	 	8.76E-03	AGT,COL1A1,COL3A1	Ap1,CD44,CMA1,ELK1,FOS,FOXO1,HGF,IL13,IL6,JUN,NFKB1,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,STAT6	
P1	 	DACT3	0.048	other	 	 	 	 	 	8.76E-03	AXIN2,DVL2,MYC	 	
P1	 	ENPP1	-0.425	enzyme	 	 	 	 	 	8.76E-03	ALPL,LEP,SPP1	 	
P1	 	FOXH1	-0.129	transcription regulator	 	 	 	 	 	8.76E-03	ALDH1A1,ALDH1A2,ALDH1A3	 	
P1	 	HDAC10	0.131	transcription regulator	 	 	 	 	 	8.76E-03	MMP2,MMP9,SQSTM1	CTNNB1,HDAC10,MMP9,NFKB1,NFkB (complex),NOTCH1,RELA,RNA polymerase II,TP53	
P1	 	LAMP2	0.701	enzyme	 	 	 	 	 	8.76E-03	HIF1A,IGF2R,RCAN1	 	
P1	 	NUCB2	1.079	other	 	 	 	 	 	8.76E-03	FOS,IL6,PTGS2	AR,Akt,CREB1,Ca2+,Creb,ERK1/2,ESR1,HIF1A,JUN,Lh,NFKBIA,NFkB (complex),NUCB2,RELA,SMAD3,SP1,STAT1,STAT3,STAT5B,TP53,testosterone	
P1	 	PDIA3	0.007	peptidase	 	 	 	 	 	8.76E-03	CD24,FCGR3A/FCGR3B,PRNP	 	
P1	 	PELI2	-0.253	other	 	 	 	 	 	8.76E-03	CXCL2,CXCL8,IL6	Ap1,ERK,IKBKG,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PELI2,RELA,SMAD3,STAT1,STAT3	
P1	 	PROM1	0.368	other	 	 	 	 	 	8.76E-03	CDH5,DSG2,NR4A2	 	
P1	 	Pou3f1	 	transcription regulator	 	 	 	 	 	8.76E-03	MBP,PMP22,ZFP42	 	
P1	 	QKI	0.115	other	 	 	 	 	 	8.76E-03	CSF1R,ERCC2,MAP1B	 	
P1	 	RGD1560225	 	other	 	 	 	 	 	8.76E-03	EDN1,ITPR2,PTGS2	 	
P1	 	RRM2	0.069	enzyme	 	 	 	 	 	8.76E-03	HIF1A,MMP9,THBS1	Ap1,BCL2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RRM2,SP1,STAT3,TP53,TP73,nitric oxide	
P1	 	RSPO3	0.582	kinase	 	 	 	 	 	8.76E-03	AXIN2,IL6,PTGS2	NFKB1,NFKBIA,NFkB (complex),RELA,RSPO3,STAT3,TNF	
P1	 	Rsk	 	group	 	 	 	 	 	8.76E-03	ATF4,CXCL2,CXCL8	Ap1,CEBPA,CEBPB,CREB1,CREBBP,CREM,Creb,IKBKB,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,Rsk	
P1	 	Stat dimer	 	complex	 	 	 	 	 	8.76E-03	BCL2L1,FOS,IL6	 	
P1	 	TRHR	0.048	g-protein coupled receptor	 	 	 	 	 	8.76E-03	LEP,LEPR,SOCS3	CEBPA,CEBPB,JUN,LEP,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT1,STAT3,TP53,TRHR	
P1	 	bafilomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	8.76E-03	ATG7,HIF1A,SQSTM1	Akt,HIF1A,JUN,NFkB (complex),STAT3,TP53,bafilomycin	
P1	 	chlorophyllin	 	chemical toxicant	 	 	 	 	 	8.76E-03	CCL2,CXCL8,HMOX1	 	
P1	 	desmosterol	 	chemical - endogenous mammalian	 	 	 	 	 	8.76E-03	ABCG1,ACSL4,DHCR24	 	
P1	 	lansoprazole	 	chemical drug	 	 	 	 	 	8.76E-03	CD14,CXCL8,PTGS2	Ap1,JUN,NFKBIA,NFkB (complex),Nr1h,P38 MAPK,RELA,RXRA,STAT1,STAT3,lansoprazole	
P1	 	microcystin-LR	 	chemical toxicant	 	 	 	 	 	8.76E-03	IL6,MMP2,MYC	CREB1,ERK1/2,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SMAD3,SP1,STAT3,TP53,TP73,microcystin-LR	
P1	 	parbendazole	 	chemical reagent	 	 	 	 	 	8.76E-03	ALPL,BMP2,SPP1	BMP2,CTNNB1,NFkB (complex),SMAD1,SMAD4,STAT3,parbendazole	
P1	 	tazarotene	 	chemical drug	 	 	 	 	 	8.76E-03	RARRES1,RARRES2,RARRES3	 	
P1	 	ticrynafen	 	chemical drug	 	 	 	 	 	8.76E-03	GCLM,HMOX1,NQO1	 	
P1	 	FGF10	-0.009	growth factor	 	-0.043	bias	0.481	-1.688	8.83E-03	AHNAK,ANXA3,BMP4,CTSB,CTSH,CYP1B1,CYP51A1,LDLR,LIPE,LSS,PERP,PTGS2,SOX9,SPRY2	CREBBP,ELK1,ERK1/2,FGF10,FGFR1,FOS,JUN,MAPK3,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,SMAD4,SP1,STAT1,STAT3,TGFB1,estrogen receptor	
P1	 	adenosine	 	chemical - endogenous mammalian	 	-0.049	 	0.041	-0.167	8.83E-03	BCL2L1,CD69,CD86,CXCL8,CXCR4,FOS,HIF1A,HMOX1,HSPA5,IL6,NR4A2,PTGS2,SOCS3,TIMP1	Ap1,CEBPA,CEBPB,ERK1/2,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,adenosine	
P1	 	CIDEC	-0.675	other	 	1.539	bias	-0.466	2.924	8.89E-03	ACADM,CCL2,CIDEA,DGAT2,EBF2,IL6,LEP,LIPE,PLIN1	Akt,CIDEC,HIF1A,JUN,NFkB (complex),STAT3,TP53	
P1	 	GPC1	2.413	transmembrane receptor	 	-1.269	 	0.056	-1.433	8.89E-03	CCND2,CCND3,CDKN2B,CDKN2C,ID1,ID3,MYC,PTGS2,SOX17	CREBBP,CTNNB1,Creb,ERK,ERK1/2,FGF2,FGFR1,FOS,GPC1,JUN,MYC,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TCF,TP53,estrogen receptor	
P1	 	JAG1	-0.325	growth factor	 	0.180	 	0.241	-0.491	8.89E-03	CD86,COL1A1,HEY1,HEY2,HEYL,MYC,PTPRK,SPP1,TAGLN	JAG1,NFkB (complex),NOTCH1,Notch,RELA,SMAD3,STAT3,TCF3,TP53	
P1	 	NF1	0.172	other	 	-1.463	bias	-0.418	-0.287	8.89E-03	AXIN2,BCL2L1,CBS/CBSL,FGF2,MDK,MRPL15,MYC,NCL,TNFRSF10B	CEBPB,CTNNB1,ERK,HIF1A,HRAS,JUN,KRAS,MYC,NF1,NFKBIA,NFkB (complex),RAC1,RELA,SMAD3,SP1,STAT1,STAT3,TP53,cyclic AMP	
P1	 	THBS1	-2.303	other	 	1.450	 	0.039	1.343	8.89E-03	CD69,CTGF,EGR1,IL6,MMP2,MMP9,THBS1,TIMP1,TNFRSF10B	CXCL12,ERK,FOS,JUN,MAPK1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT1,STAT3,THBS1	
P1	 	arginine	 	chemical - endogenous mammalian	 	-0.199	 	0.093	-0.465	8.89E-03	BCL2L1,DDIT3,EGR1,HDC,HIF1A,HSPA5,PCK2,PTGS2,SLC7A5	Ap1,CEBPB,D-glucose,FOXO1,FOXO3,HIF1A,IGF1,INS,JUN,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SMAD3,SP1,STAT3,arginine	
P1	 	formaldehyde	 	chemical - endogenous mammalian	Inhibited	-2.118	bias	0.456	-3.363	8.89E-03	EGR1,EGR2,FOS,FOSB,JUN,JUNB,MMP9,PTGS2,SGK1	CEBPB,CREB1,CREBBP,CREM,Creb,ELK1,ERK1/2,FOS,JUN,MAPK1,MAPK3,NFKB1,NFKBIA,NFkB (complex),PRKCE,RELA,SMAD3,SP1,STAT1,STAT3,formaldehyde	
P1	 	leucine	 	chemical - endogenous mammalian	 	-0.050	 	0.039	-0.157	8.89E-03	ACACA,ASNS,ATF3,ATF4,CRAT,DDIT3,FOS,LEPR,PPP1R15A	ATF2,Ap1,CEBPA,CEBPB,FOS,FOXO1,Growth hormone,HIF1A,Ins1,Insulin,JUN,NFkB (complex),PI3K (complex),PPARA,PPARG,RELA,SP1,STAT3,ethanol,leucine	
P1	 	TNFRSF1A	0.264	transmembrane receptor	 	-0.769	 	0.242	-1.907	8.96E-03	ABCC1,ABCC3,BCL2L1,BIRC3,CCL2,CCL3L3,CD68,CD86,CDH2,CTGF,CXCL2,CXCL8,GCLM,IL6,ITGAM,JUN,KDR,LBP,MMP2,MMP9,NQO1,P2RX7,SAA1,SELE,SOCS3,SRC,VCAM1	Ap1,IL6,JUN,Jnk,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNFRSF1A,TNFRSF1B,Tnf (family)	
P1	 	FOXA1	0.050	transcription regulator	 	-0.931	 	0.013	-0.979	9.07E-03	ACTG2,BMP2,CNN1,COL18A1,EFHD1,EPHX1,ESR1,FKBP4,FOXC1,HK1,IL6,LYN,MGP,MYC,MYH11,NR4A2,PALM2,PFKFB1,PRNP,RARA,SIAH2,SLC12A2,SOX9,TAGLN,TF,TFF3,THBS3,TNFRSF12A	AR,ATF6,ATF6B,Ap1,CEBPA,CEBPB,FOS,FOXA1,GATA4,Ins1,JUN,NCOR1,NFE2L2,NFkB (complex),NR3C1,PPARA,PPARG,RELA,RXRA,SP1,STAT3,TP53,XBP1,estrogen receptor	
P1	 	1-methyl-4-phenylpyridinium	 	chemical toxicant	 	1.274	bias	0.290	0.525	9.11E-03	ATF4,DDIT3,DDIT4,HIF1A,PIN1,TFRC,TRIB3	1-methyl-4-phenylpyridinium,EIF2AK3,FOXO1,FOXO3,GSK3B,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SNCA,STAT1,STAT3,TP53,VHL,iron	
P1	 	EPOR	-0.220	transmembrane receptor	 	 	 	 	 	9.11E-03	BCL2L1,CCND2,JUN,JUNB,MYC,SOCS3,SPI1	EPO,EPOR,ESR1,FOS,FOXO3,HIF1A,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,STAT5a/b,Shc	
P1	 	HTATIP2	-0.207	transcription regulator	 	0.305	bias	-0.501	 	9.11E-03	ANGPT1,CDH2,FOS,MMP2,MYC,SPARC,SPP1	ATF2,Ap1,EGFR,ERK1/2,HTATIP2,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SMAD3,SP1,STAT3,TP53,hyaluronic acid	
P1	 	NRTN	0.105	growth factor	 	0.264	 	0.167	-0.177	9.11E-03	EGR1,EGR2,FOSB,GFRA2,IL6,RET,TRPM8	CEBPA,CEBPB,ERK1/2,FOXO3,IL6,NFKB1,NFKBIA,NFkB (complex),NRTN,RELA,RET,SMAD3,SP1,STAT1,STAT3,TNF,TP53	
P1	 	RHOJ	0.190	enzyme	 	 	 	 	 	9.11E-03	ADIPOQ,AKAP12,ATP2A2,CAV1,LRP1B,PLAT,PPP2R1A	 	
P1	 	WWOX	0.055	enzyme	Inhibited	-2.607	 	-0.132	-2.263	9.11E-03	BCL2L1,COL1A1,ESR1,IL6,ITGA3,MMP9,TIMP4	ERK,FN1,FOS,GSK3B,Hdac,JUN,MYC,NFKB1,NFkB (complex),RELA,SMAD3,SP1,STAT1,STAT3,TP53,TP63,TP73,WWOX	
P1	 	IL18	-0.003	cytokine	 	0.109	bias	0.408	-1.979	9.15E-03	ACTA1,ADIPOQ,BCL2L1,BSG,CCL2,CCL3,CCL3L3,CD69,CD86,CXCL12,CXCL16,CXCL8,FCGR3A/FCGR3B,GADD45B,HAVCR2,IDO1,IL18RAP,IL6,ITGAM,JUN,KIT,MMP9,NFKBIZ,PTGS2,SPP1,TF,TGFBR2,TIMP1,VCAM1	Ap1,IFNG,IL18,IL1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TNF	
P1	 	8-chlorophenylthio-adenosine 3',5'-cyclic monophosphate	 	chemical - kinase inhibitor	 	0.124	 	0.212	-0.593	9.17E-03	ACADM,ATP2A2,BCAT2,BIRC3,CD36,CEBPD,DDIT3,DUSP1,LIPE,LPIN1,LPIN2,S100A8,THRSP	8-chlorophenylthio-adenosine 3',5'-cyclic monophosphate,CEBPA,CEBPB,CREB1,CREBBP,CTNNB1,Creb,DDIT3,EP300,FOXO1,HIF1A,JUN,MTOR,NFAT (complex),NFKB1,NFKBIA,NFkB (complex),PPARG,Pka,RELA,STAT1,STAT3,TP53	
P1	 	EGLN1	-0.131	enzyme	 	0.398	 	-0.033	0.510	9.17E-03	ADM,CD86,CDKN2B,CXCR4,EPAS1,HIF1A,IL6,LEP,MYC,NGF,PTGS2,SDC4,TGFBR2	ARNT,Ap1,EGLN1,EPAS1,ETS1,HIF1A,KLF2,MYC,NFkB (complex),PPARG,RELA,RNA polymerase II,SMAD3,SMAD4,SMAD7,SP1,STAT3,Smad,VEGFA,VHL	
P1	 	vorinostat	 	chemical drug	 	1.276	 	0.003	1.258	9.23E-03	ADAMTS1,ATG7,BCL2L1,BIRC3,BMF,CD69,CDH2,CTSD,CYP1B1,DUSP1,EDN1,ERBB2,GRN,HSPA5,IL6,JUN,KIT,LTBR,MCL1,MMP2,MMP9,MYC,NDRG1,NFKBIA,PTGS2,SOCS3,SPI1,TEK,TNFRSF10B,TNFSF10,TXN,VEGFC,ZFPM1	ARNT,Ap1,EGR1,HIF1A,JUN,Jnk,LY294002,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT3,TNFSF10,VHL,vorinostat	
P1	 	amphetamine	 	chemical drug	Inhibited	-2.332	bias	0.276	-3.112	9.25E-03	ATF3,ATF4,BCL2L1,BMP4,CDH2,CSF1R,EFNB2,EGR1,FOS,FOSB,HSPA4,HSPA8,JUN,JUNB,MYOM1,SGK1,STIP1,TGFBR2,TNFAIP3,UCHL1	CEBPB,CREB1,CREBBP,CREM,Creb,DRD2,ERK1/2,FOS,Growth hormone,JUN,L-glutamic acid,MAPK1,NFKBIA,NFkB (complex),RELA,SMAD3,SP1,SP3,STAT1,STAT3,amphetamine	
P1	 	TLR3	-0.459	transmembrane receptor	Inhibited	-2.451	bias	0.465	-5.243	9.29E-03	ARG2,ARRDC4,ATF3,CAST,CCL2,CCL3,CCL3L3,CD69,CD86,CFB,CTSK,CXCL2,CXCL8,DEFB1,DUSP1,EDN1,FOS,GADD45B,GBP4,HMOX1,ID1,IER3,IFIT2,IL6,IRF3,ISG20,JUNB,LIPG,LPIN2,MAP3K8,N4BP1,NFKBIZ,PFKFB3,PHLDA1,PROCR,PTGS2,PTX3,RGS1,RHBDD3,RHOB,S100A8,SELE,SOCS3,SPRY1,TIMP1,TNFSF10	IFNG,IL10,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),RELA,STAT1,STAT3,TICAM1,TLR3,poly rI:rC-RNA	
P1	 	andrographolide	 	chemical drug	 	-0.277	 	-0.072	-0.065	9.35E-03	BCL2L1,HMOX1,IL6,MMP9,PTGS2,RGN,SELE,SRC,TIMP1,VCAM1	Ap1,EP300,FOS,HIF1A,HMOX1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,andrographolide,nitric oxide	
P1	 	ITGA5	0.396	transmembrane receptor	 	0.860	bias	0.329	-0.192	9.41E-03	APOE,CDH2,CDK4,ENPP2,ERBB2,FOS,JUN,JUNB,MMP2,MMP9,PLAUR,TGFBR2	ATF2,Ap1,CTNNB1,EGFR,EGR1,ESR1,FN1,HIF1A,ITGA5,ITGB1,JUN,NFKB1,NFkB (complex),RAC1,RELA,SMAD3,SP1,STAT1,STAT3,STAT5a/b,TP53	
P1	 	U73122	 	chemical reagent	 	-1.698	bias	-0.478	-0.068	9.41E-03	AGT,ATF4,ATP2A2,CCND2,HSPA5,ITGAM,ITPR2,MMP2,PTGS2,SELE,TPM1,VCAM1	Akt,HIF1A,IFNG,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT3,TNF,TP53,U73122	
P1	 	captopril	 	chemical drug	 	1.987	 	0.122	1.477	9.43E-03	AGT,ASNS,CAPN6,EFEMP2,GSTM3,HMOX1,IER3,IGFBP6,IL6,LTBP2,MAOA,MMP9,PTGS2,SPP1,THBS4,TIMP1,TNFRSF12A,UPP1	AGT,AKT1,ALB,AMPK,Ap1,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,SMAD3,SP1,SQSTM1,SREBF1,STAT1,TP53,captopril,fatty acid	
P1	 	RUNX2	0.054	transcription regulator	 	1.206	 	0.242	0.105	9.45E-03	ALPL,AXIN2,BMP2,CDH2,CEBPD,COL11A1,COL1A1,COL1A2,CSNK2B,CXCL8,FLRT2,GADD45B,HIF1A,IL20RB,LUM,MMP2,MYH11,RUNX1,SMAD6,SPP1,TAGLN,TIMP1,TPM1,TPSAB1/TPSB2	ARNT,HIF1A,MYC,MYOCD,NFkB (complex),NOTCH1,PPARG,PTK2,RELA,RUNX2,SMAD3,SMAD4,SMAD7,SP1,SRF,STAT1,STAT3,Smad,TP53,VHL	
P1	 	THRB	0.027	ligand-dependent nuclear receptor	 	1.269	 	0.146	0.530	9.91E-03	ACACA,ATP2A2,BTG2,CCL2,CCND2,CCND3,CDK4,CTSD,CTSH,CXCL2,FOS,FRZB,FZD7,FZD9,GDI1,HIF1A,ID1,IL6,JUN,LYZ,MBP,ME1,MMP2,NME1,NR5A2,PGD,PLA2G2A,PLIN1,POR,PTGDS,SFRP1,SFRP2,SFRP4,TCEA3,THRSP,WNT5B	AKT1,Akt,Ap1,CEBPB,EP300,HIF1A,JUN,L-triiodothyronine,NCOR1,NFKB1,NFkB (complex),PI3K (complex),PPARA,PPARG,PPARGC1A,RXRA,SP1,STAT1,STAT3,THRB,TP53	
P1	 	carbon monoxide	 	chemical - endogenous mammalian	Activated	2.033	 	-0.191	2.758	9.92E-03	ATF4,CAV1,CCL2,CD14,CXCL12,DDIT3,EGR1,HIF1A,HMOX1,IL6,LEP,NCF2,NQO1,PLAUR,PTGS2	Ap1,CEBPA,CEBPB,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT1,STAT3,TNF,TP53,carbon monoxide	
P1	 	miR-21-5p (and other miRNAs w/seed AGCUUAU)	 	mature microrna	Activated	2.062	bias	-0.501	 	9.92E-03	BCL2L1,BTG2,CD69,CDH5,IRAK1,KDR,MMP2,PDCD4,PELI1,SMAD7,SPRY1,SPRY2,TAGLN,TGFBR2,TPM1	CEBPA,CEBPB,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PTEN,RELA,SMAD1,SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,Smad,TP53,miR-21-5p (and other miRNAs w/seed AGCUUAU)	
P1	 	seocalcitol	 	chemical drug	 	0.901	bias	0.348	-0.441	9.92E-03	BCL2L1,BLOC1S1,GADD45A,ITGA7,MCL1,MST1,NGF,NINJ1,NOMO1 (includes others),PDLIM7,PTGS2,SGK1,SNU13,TSPAN6,UVRAG	CREB1,Ca2+,ERK,JUN,NFKBIA,NFkB (complex),P38 MAPK,RELA,SMAD3,SP1,STAT3,TP53,seocalcitol	
P1	 	10-nitrooleate	 	chemical - endogenous mammalian	 	1.664	bias	-0.368	2.559	9.98E-03	CXCL8,IL6,NOX4,PTGS2,SELE,VCAM1	10-nitrooleate,CHUK,FOXO1,HIF1A,JUN,NFKB1,NFKB2,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TP53	
P1	 	ADRBK1	0.598	kinase	Activated	2.433	bias	-0.319	3.209	9.98E-03	ACTA1,C5AR1,CDKN2B,FOS,LHCGR,MYH11	ADRA1B,ADRBK1,CREB1,CTNNB1,ELK1,FOS,FOXO1,FOXO3,HMGA1,IRS1,JUN,Lh,MAPK3,NFkB (complex),SMAD3,SMAD4,SMAD7,SP1,STAT1,STAT3,STAT5B,Smad	
P1	 	ENPP2	-0.990	enzyme	 	0.816	bias	-0.301	1.553	9.98E-03	ADIPOQ,CIDEA,ENPP2,IL6,ITGAM,LEP	Akt,ENPP2,HIF1A,JUN,NFkB (complex),STAT3,TP53	
P1	 	Fgfr	 	group	 	0.000	bias	0.435	-1.065	9.98E-03	BCL2L1,FOS,HEY1,HEY2,HMOX1,SPP1	Akt,Ap1,CREB1,ERK,FOS,Fgfr,HIF1A,JUN,NFKBIA,NFkB (complex),PI3K (complex),Pkc(s),RELA,SMAD3,SP1,STAT3,TP53,hyaluronic acid	
P1	 	INSIG2	-0.209	other	Inhibited	-2.392	bias	-0.501	 	9.98E-03	ACACA,ACLY,ELOVL6,G6PD,GPAM,LDLR	INSIG2,NFE2L2,NFkB (complex),PPARGC1A,RELA,SREBF1,SREBF2,STAT3,TP53,cholesterol	
P1	 	PGF	-0.012	growth factor	 	-1.729	bias	0.501	 	9.98E-03	CCL2,CXCL8,CXCR4,EDN1,IL6,MMP9	Akt,Ap1,ERK1/2,ETS1,HIF1A,JUN,Jnk,NFKBIA,NFkB (complex),P38 MAPK,PGF,RELA,SMAD3,STAT3,TP53,VEGFA	
P1	 	PPP1R1B	-1.020	phosphatase	 	-0.034	bias	0.435	-1.078	9.98E-03	BCL2L1,ERBB2,FOS,GSK3B,LRRK2,MYC	Akt,ERBB2,ERK,FOXO3,GSK3B,HIF1A,JUN,MYC,NFKB1,NFkB (complex),PPP1R1B,RELA,SMAD3,SP1,STAT1,STAT3,TP53,estrogen receptor,trastuzumab	
P1	 	PROCR	-0.841	other	Inhibited	-2.412	bias	0.435	-3.460	9.98E-03	ANGPT1,GBP4,MMP9,PELI1,TEK,TJP1	Ap1,F2,F2R,JUN,NFKB1,NFKBIA,NFkB (complex),PROC,PROCR,RELA,SP1,STAT3	
P1	 	ROCK1	-0.056	kinase	 	0.651	bias	0.430	-0.300	9.98E-03	ACTA1,CCND2,CCND3,EDN1,ETS1,VCAM1	Akt,CREB1,D-glucose,ERK1/2,FOS,HIF1A,INSR,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PDX1,PPARG,RELA,ROCK1,SMAD3,STAT3,STAT5a/b,TP53	
P1	 	S1PR2	-0.072	g-protein coupled receptor	 	-0.830	bias	0.435	-1.875	9.98E-03	FOS,JUN,PTGS2,SELE,TIMP1,VCAM1	Akt,Ap1,CEBPB,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,S1PR2,STAT1,STAT3,TP53,cyclic AMP	
P1	 	SELENOS	-0.293	other	 	-0.294	bias	-0.501	 	9.98E-03	ADIPOQ,ATF6,CAV1,DDIT3,HSPA5,IL6	 	
P1	 	amlodipine	 	chemical drug	 	0.816	bias	-0.347	1.667	9.98E-03	ACTA1,COL1A1,EDN1,ENO1,LDLR,PTGS2	ATF2,CREB1,EGFR,ERK,FOS,JUN,NFKB1,NFkB (complex),PLG,Pkc(s),RELA,SMAD3,SP1,STAT1,STAT3,amlodipine	
P1	 	cobalt	 	chemical toxicant	 	0.128	bias	0.430	-0.918	9.98E-03	ESR1,FGF2,HIF1A,IL6,PFKFB1,PFKFB3	ARNT,EPAS1,HIF1A,MYC,NFkB (complex),PPARG,RUNX2,SP1,STAT3,TP53,TP73,VHL,cobalt	
P1	 	epoprostenol	 	chemical - endogenous mammalian	 	-0.714	 	0.143	-1.028	9.98E-03	EGR1,FOS,HIF1A,PTGIS,PTGS2,SPP1	Ap1,CEBPB,CREB1,Ca2+,EP300,GNA13,JUN,NADPH oxidase,NFATC3,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,SREBF1,SRF,STAT1,STAT3,TP53,cyclic AMP,epoprostenol	
P1	 	isoquercitrin	 	chemical drug	Activated	2.449	bias	0.435	1.385	9.98E-03	ACAT2,CYP51A1,DHCR7,LDLR,MSMO1,SQLE	PPARGC1A,SREBF1,SREBF2,TP53,isoquercitrin	
P1	 	tauroursodeoxycholic acid	 	chemical - endogenous mammalian	 	-1.067	 	0.201	-1.465	9.98E-03	ADIPOQ,BCL2L1,CTGF,DDIT3,DLG4,HSPA5	ADIPOQ,AKT1,Ap1,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PRKCA,PRKCE,RELA,SMAD3,SP1,STAT1,STAT3,TP53,tauroursodeoxycholic acid	
P1	 	GATA6	-0.032	transcription regulator	 	-0.767	 	-0.058	-0.455	9.99E-03	AMHR2,ATP6V0A2,C1R,CAV1,CD163,CLEC10A,CNFN,CRABP2,CRYL1,CYP11A1,DAB2,EDN1,EMD,EMX2,EVPL,FGF2,HYAL1,KLF2,LHCGR,LYVE1,MARCO,MYH11,MYLK,NR5A2,PPP1R14A,SEMA3C,SOX17,SOX7,SPARC,STARD13,SUCLA2,TAGLN,THRSP,TNFSF10,VSIG4	AR,FOXO3,GATA6,NFkB (complex),NR3C1,NR3C2,corticosterone	
P1	 	CNTF	0.038	cytokine	 	-0.075	 	0.078	-0.341	1.00E-02	CEBPD,CXCL8,EGR1,FGF2,FOS,JUNB,LBP,LEP,NGF,NOTCH1,PDE1B,POMC,PPP1R1B,SATB2,SERPINA3,SOCS2,SOCS3,TIMP1,ZFP36	 	
P1	 	AIFM1	0.459	enzyme	Activated	2.202	bias	0.501	 	1.00E-02	CHCHD4,COX17,NDUFA13,NDUFA9,NDUFS7	 	
P1	 	CACNA1A	0.353	ion channel	 	 	 	 	 	1.00E-02	BTG1,CD68,GRN,IL6,ITGAM	 	
P1	 	DSP	-0.043	other	 	-1.387	 	-0.137	-1.083	1.00E-02	ADIPOQ,COL1A1,COL1A2,COL3A1,PKP1	 	
P1	 	ELK3	-0.068	transcription regulator	 	-0.372	bias	-0.251	0.057	1.00E-02	CCT8,EGR1,ERBB2,FOS,HMOX1	 	
P1	 	Fe2+	 	chemical - endogenous mammalian	 	0.447	 	-0.228	0.957	1.00E-02	CCL3L3,HIF1A,HMOX1,TF,TFRC	 	
P1	 	HCK	0.067	kinase	 	-1.408	 	0.137	-1.706	1.00E-02	CD36,ELK1,IL6,MAOA,SRC	 	
P1	 	Integrin	 	complex	 	-1.069	bias	0.501	 	1.00E-02	FOS,JUN,MMP9,MYC,SOCS3	 	
P1	 	MAPK10	0.473	kinase	Inhibited	-2.193	bias	0.410	-3.092	1.00E-02	CXCL8,FOS,IL6,JUN,PTGS2	 	
P1	 	NUMBL	0.399	other	 	-0.277	bias	-0.319	0.431	1.00E-02	ATF6,KLF4,MMP9,MYC,SPARC	 	
P1	 	Rac	 	group	 	-1.982	bias	0.501	 	1.00E-02	BMP2,CCL2,FOS,IL6,PTGS2	 	
P1	 	T 0070907	 	chemical reagent	 	1.231	 	-0.046	1.332	1.00E-02	ADIPOQ,COL1A1,COL1A2,HMOX1,PTGS2	 	
P1	 	ferric ammonium citrate	 	chemical drug	 	0.490	 	0.046	0.388	1.00E-02	ELN,FTH1,GADD45A,HMOX1,MYC	 	
P1	 	latrunculin B	 	chemical reagent	 	1.982	bias	-0.401	2.778	1.00E-02	ACTA1,CTGF,FOS,MYOC,TAGLN	 	
P1	 	naringin	 	chemical - endogenous non-mammalian	 	0.447	bias	-0.279	1.070	1.00E-02	CAT,CCL2,CXCL8,HMOX1,MMP9	 	
P1	 	rosmarinic acid	 	chemical - endogenous non-mammalian	 	1.067	bias	-0.376	1.813	1.00E-02	CTGF,CXCL8,IL6,MMP2,PTGS2	 	
P1	 	salubrinal	 	chemical reagent	 	-1.393	 	-0.228	-0.892	1.00E-02	ATF4,ATF6,DLG4,HSPA5,SQSTM1	 	
P1	 	sorbitol	 	chemical - endogenous mammalian	 	-0.934	bias	0.301	-1.516	1.00E-02	AKR1B1,BCL2L1,SGK1,SLC1A3,SORD	 	
P1	 	trypsin	 	group	 	0.152	bias	0.279	-0.400	1.00E-02	CXCL8,ELN,FOS,MIF,PTGS2	 	
P1	 	DKK1	-0.484	growth factor	 	0.484	bias	-0.276	1.466	1.05E-02	AXIN2,BMP4,BMP6,COL1A1,DLG4,DPAGT1,DVL3,GSK3B,MMP9,MYC,SOX9,SPARC,TAGLN,TTYH1	 	
P1	 	N-acetylmuramyl-L-alanyl-D-isoglutamine	 	chemical - endogenous non-mammalian	 	-1.483	bias	0.457	-2.876	1.05E-02	AOX1,AXIN2,CARD9,CCL2,CCL8,CD86,CXCL2,CXCL8,ETS1,IDO1,IL6,MMP9,NFKBIA,PTGS2	 	
P1	 	GNRH	 	group	Inhibited	-2.141	bias	0.301	-2.927	1.06E-02	ADIPOQ,ATF3,DUSP1,EGR1,FOS,JUN,PTGS2,SGK1	 	
P1	 	Stat3-Stat3	 	complex	 	-0.049	bias	0.501	 	1.06E-02	BCL2L1,FCER2,JUN,LBP,MYC,POMC,SERPINA3,SOCS3	 	
P1	 	TRPV4	0.090	ion channel	 	-1.450	bias	0.418	-2.622	1.06E-02	CCL3L3,CXCL2,FOS,IL6,SOCS3,THBS1,TIMP1,VCAM1	 	
P1	 	oleoyl-estrone	 	chemical drug	 	-1.091	 	-0.240	-0.463	1.06E-02	ACACA,ACADVL,CYP2C8,G6PD,LDLR,LIPE,PRMT1,SLC27A1	 	
P1	 	RORA	-0.323	ligand-dependent nuclear receptor	 	0.805	bias	0.266	-0.222	1.07E-02	ACSL4,ADGRL1,ADIPOR2,APOE,ASNS,CCL3L3,CD36,CH25H,CXCL8,CYP27A1,CYP2C8,DHCR24,ELOVL3,ELOVL6,GADD45B,GOT1,GSTM2,IL6,LPIN2,NAALAD2,NFKBIA,NLGN1,NNMT,NR1D1,PLIN2,POR,PPP1R3C,PTGS2,S100A8,S100A9,SLC15A4,SLC29A4,SLC2A3,SLC41A2,SOCS3,SULF2,UCP2	 	
P1	 	NGF	0.839	growth factor	Activated	2.143	bias	0.288	0.487	1.08E-02	ASIC1,ATF3,BCL2L1,BTG2,CAV1,CD86,DLG4,DUSP1,EGR1,EGR2,ELK1,EPAS1,ETV5,FOS,GADD45A,GAP43,GSK3B,GUCY1A3,HMOX1,ID1,JUN,JUNB,KIF2A,MAP3K12,MAPK8IP3,MMP2,MMP9,MT1A,MYC,MYCN,PLA2G4A,PLAUR,SHC1,SQSTM1,TNFRSF12A,TXN	 	
P1	 	GAST	0.102	other	 	1.175	bias	0.408	-0.447	1.08E-02	ATF4,BTK,EGR1,FOS,HBEGF,HDC,IMPDH2,JUN,MMP9,MYLK,NARS,ODC1,POMC,POR,PTGS2,SLC4A2,SRC,VCAM1	 	
P1	 	fluoxetine	 	chemical drug	 	-0.056	 	0.167	-0.753	1.08E-02	CLOCK,EGR1,FGF2,FOS,FOSB,GNAI1,GNAZ,IL6,LSS,MMP2,MTOR,MYC,NME1,POMC,PPP1R1B,SERPINA3,SLC2A3,TAGLN	 	
P1	 	NEUROG1	-0.010	transcription regulator	 	-0.258	 	-0.103	0.143	1.09E-02	ASS1,C1orf115,CCND2,COL3A1,EPAS1,FAM65B,GFPT2,IL6,LRRN3,MFAP4,MMP9,NEO1,P4HA2,SDPR,SULF1,THBS1	 	
P1	 	mir-210	-0.064	microrna	Inhibited	-2.169	bias	-0.458	-0.126	1.10E-02	ABCC3,ABL1,ALDH5A1,CBX1,CDH2,CTGF,CXCL12,DDOST,ELOF1,EPB41L1,FAM102A,FCER2,GDE1,HOXA9,INHBB,ISCU,KDR,KIAA0930,KLF6,NDRG1,SCARA3	 	
P1	 	EPHB4	0.020	kinase	 	-0.832	bias	0.317	-1.976	1.10E-02	BMP2,BMP4,CSF2RA,CXCR4,IGFBP4,KDR,KIT,PDLIM7,RUNX1,SMAD6,TEK,TGFBR2,ZFP42	 	
P1	 	HAND2	-0.221	transcription regulator	 	-0.747	bias	0.283	-1.760	1.10E-02	ADSSL1,ATP2A2,CASQ2,CLSTN2,COL1A1,COL1A2,COL3A1,ECM2,HSPB7,LOC102724428/SIK1,PLA2G2A,PTPRB,TPM1	 	
P1	 	PTGER4	-1.158	g-protein coupled receptor	 	0.763	 	-0.123	1.401	1.12E-02	CCL2,CCL3L3,CCNG2,CD69,CH25H,CXCL8,CXCR4,EDN1,EGR1,FAM49A,GBP4,HAVCR2,HCAR2,IFIT2,IGF2BP2,IL6,ISG20,LHFPL2,MMP2,NCF2,PDCD4,PTGS2,RNF144B,RNF24,S100P,S1PR1,SLAMF8,TNFSF10,XAF1	 	
P1	 	MAP3K8	-1.566	kinase	 	-1.120	 	0.063	-1.440	1.12E-02	APOE,BIRC3,CCR1,CEBPD,COBLL1,COLEC12,CXCL2,CXCL8,DOK2,FOS,FSCN1,GCA,GPR146,GPR160,HP,IER3,IL6,IRF2BPL,JUN,MARCO,MMP9,NGF,PLAT,PTGER4,PTGS2,SOCS3,SPATS2L,ST3GAL3,TUBB2B,UBALD1	 	
P1	 	Mapk	 	group	 	-1.150	bias	0.446	-2.787	1.13E-02	BCL2L1,CAT,CCL2,COL1A1,CXCL8,DBP,DLG4,EGR1,ESR1,FOS,HMOX1,IL6,JUN,JUNB,LEP,MMP9,MYC,NR4A3,PTGS2,S100A8,SPP1,VCAM1	 	
P1	 	bufalin	 	chemical reagent	 	-0.378	 	-0.167	0.064	1.14E-02	CDK4,DDIT3,EGR1,FOS,HSPA5,MCL1,MMP2,RPLP0,TNFRSF10B	 	
P1	 	FGF21	0.444	growth factor	 	0.863	 	0.198	0.190	1.14E-02	ACACA,ACADM,ACLY,ADIPOQ,CIDEA,DGAT2,EGR1,HMGCL,IRS2,LDLR,LEP,ME1	 	
P1	 	KLF15	0.328	transcription regulator	 	0.697	bias	0.330	-0.331	1.14E-02	ACADM,ACADVL,ACAT1,CD36,CMKLR1,CTGF,DGAT2,GPAM,GPR1,HADHA,PDK4,SLC27A1	 	
P1	 	N-acetylsphingosine	 	chemical reagent	 	-1.754	 	0.160	-2.297	1.14E-02	CAT,COL1A1,COL1A2,COL3A1,CXCL2,CXCL8,FOS,GSTM5,JUN,PDE3B,PTGS2,RARA	 	
P1	 	NOTCH3	-0.462	transcription regulator	 	0.426	bias	0.383	-0.718	1.14E-02	ACTN1,ARHGEF4,CDKN1C,COL5A1,HEY1,HEY2,ID1,MYH11,PRAG1,PTX3,SPARC,TAGLN	 	
P1	 	lipid A	 	chemical toxicant	 	-0.588	bias	0.478	-2.087	1.14E-02	C2,CCL2,CCL3L3,CD14,CD36,CD86,CXCL8,IL6,LYN,MARCO,PRKCD,THBS1	 	
P1	 	NR0B2	0.032	ligand-dependent nuclear receptor	 	-0.242	bias	-0.418	1.052	1.16E-02	ACACA,ACADM,ACLY,AGT,CD36,CEL,CYP11A1,CYP51A1,EGR1,FBP1,HDC,LPIN1,PCK2,PDK4,TIMP1	 	
P1	 	NFYC	0.453	transcription regulator	 	 	 	 	 	1.17E-02	COL1A1,COL1A2,COL5A3,EMX2,FTH1,LPIN1,PTTG1,RHOB,SGK1,THRSP,TXNDC12	 	
P1	 	tetraethylammonium	 	chemical drug	 	-0.971	 	-0.116	-0.589	1.17E-02	ARHGDIA,BCL2L1,DPH5,FTH1,HADHA,HSPA8,HSPA9,NDUFS8,RPLP0,SARS,TBCB	 	
P1	 	NOS3	0.249	enzyme	 	-1.311	 	0.094	-1.603	1.17E-02	ACTA1,ADIPOQ,ATF3,CCL2,CD86,CXCL12,IL6,MMP2,PTGS2,VCAM1	 	
P1	 	TEAD4	0.041	transcription regulator	 	 	 	 	 	1.17E-02	ACTA1,BMP4,CTGF,GATAD2A,HIF1A,JUN,JUNB,MYH1,RCAN1,SLC2A3	 	
P1	 	acetovanillone	 	chemical drug	 	-0.566	bias	-0.354	0.536	1.17E-02	CACNA1H,CCL2,EDN1,HMOX1,MMP2,MMP9,NCF2,OSGIN1,PTGS2,UCP2	 	
P1	 	diclofenac	 	chemical drug	 	1.732	 	-0.046	1.872	1.17E-02	ATF6,FOS,GDF15,HIF1A,IL6,ITGAM,MYC,PTGS2,TMEM100,VEGFC	 	
P1	 	temozolomide	 	chemical drug	 	-0.000	 	0.049	-0.144	1.17E-02	BCL2L1,CCL2,CXCL8,DDIT3,MGMT,MMP2,MMP9,NFKBIA,QPRT,TNFRSF10B	 	
P1	 	GCG	0.025	other	 	1.054	bias	0.261	-0.002	1.17E-02	ACADM,ADIPOQ,BCL2L1,BMP4,BTG2,CBS/CBSL,CCL2,FAM46A,FOS,FST,HK1,IGFBP4,IVD,LPIN1,ODC1,PPP1R3C,VCAM1	 	
P1	 	TCOF1	0.049	transporter	 	 	 	 	 	1.17E-02	ADM,AK4,AKR1B1,AMHR2,AZIN1,BNIP3L,CAPRIN1,EPB41L1,GALK1,NDRG1,NUDT14,NUP155,PPRC1,S100A16,TBRG4,TXNRD1,UTP4	 	
P1	 	NTRK2	0.432	kinase	 	-0.731	bias	0.437	-2.292	1.24E-02	BMP2,CDCA5,CDK4,CDKN2B,CDKN2C,DDX11,FOS,HEY2,MYC,POMC,SERTAD1,SPP1,SYN1,TNFSF10	 	
P1	 	PLAG1	1.212	transcription regulator	 	1.655	bias	0.337	0.405	1.24E-02	ATF5,CDKN1C,CLTB,FLNC,LSP1,NPTXR,PIR,PLAG1,PLEC,QSOX1,SRPK3,STX1A,TGM2,TPSAB1/TPSB2	 	
P1	 	CDC73	0.005	other	 	 	 	 	 	1.24E-02	H19,HIST1H1C,HMGA1,HOXA9,IGFBP4,MYC,RUNX1	 	
P1	 	EZR	0.479	other	 	1.298	 	0.088	1.068	1.24E-02	BCL2L1,BOP1,CDH2,EIF4EBP1,MMP2,MMP9,TMEM8B	 	
P1	 	L-buthionine (SR)-sulfoximine	 	chemical drug	 	1.226	 	0.167	0.827	1.24E-02	CD36,HMOX1,NFKBIA,NQO1,TNFAIP3,TNFRSF10B,TPO	 	
P1	 	MAFK	0.012	transcription regulator	 	0.401	bias	0.251	-0.137	1.24E-02	ABCC3,GCLM,HMBS,HMOX1,NQO1,TXN,TXNRD1	 	
P1	 	Ras homolog	 	group	 	-1.270	 	0.167	-1.637	1.24E-02	CTGF,EGR1,FOS,MMP9,MYC,PTGS2,TJP1	 	
P1	 	SOCS6	-0.351	other	 	0.378	 	0.150	-0.020	1.24E-02	CEBPD,CXCL2,HBEGF,MARCO,PLAT,PTGS2,RGCC	 	
P1	 	butaprost	 	chemical drug	 	-1.157	 	0.050	-1.282	1.24E-02	CCL3L3,CTGF,IL6,MMP9,PTGS2,SOCS3,TGFBR3	 	
P1	 	dacinostat	 	chemical drug	 	-0.126	bias	-0.251	0.526	1.24E-02	ABL1,BCL2L1,CEBPD,ERBB2,HIF1A,TEK,TNFRSF10B	 	
P1	 	NFATC1	0.084	transcription regulator	 	-0.759	bias	0.388	-2.176	1.24E-02	ACP5,COL1A1,CTSK,CYP1B1,EDN1,GPC6,IL6,ITPR2,MYC,MYH11,NOX4,NQO1,PAG1,PLS3,PTGS2,RCAN1,TNFSF10,VCAM1	 	
P1	 	silibinin	 	chemical drug	 	0.535	bias	-0.358	1.838	1.26E-02	CDK4,CTGF,CXCL8,EGR1,GSK3B,HIF1A,IGFBP3,IL6,MCL1,MMP2,MMP9,MYC,NFKBIA,PLAUR,PTGS2,TNFRSF10B	 	
P1	 	berberine	 	chemical drug	 	0.430	 	-0.116	0.866	1.27E-02	ACACA,ADIPOQ,ADRBK1,BSG,CCL2,CD86,CDK4,CLDN5,CXCL8,ERBB2,HIF1A,HMOX1,IL6,LDLR,MCL1,MMP2,MMP9,PTGS2,TIMP1,TRPM8,UCP2,VCAM1	 	
P1	 	TAC1	0.106	other	Inhibited	-2.393	bias	0.448	-4.194	1.30E-02	CCL2,CXCL8,CXCR4,CYR61,FCER1A,FOS,FOSB,HDC,HIF1A,HMOX1,IL6,KCND2,MME,NGF,PLAT,PTGS2,SELE,SERPINI1,ZFPM1	 	
P1	 	potassium chloride	 	chemical drug	 	-1.756	bias	0.355	-2.967	1.30E-02	ATF3,ATP2B1,BTG2,CIDEA,DDIT3,EGR1,EGR2,FOS,HSPA5,ID1,ID3,JUN,MYC,NR4A2,NR4A3,ODC1,PTGS2,SPP1,UNC5B	 	
P1	 	ADRA1A	1.173	g-protein coupled receptor	 	 	 	 	 	1.31E-02	APBA3,CEBPD,COL3A1,DUSP1,EGR1,EGR2,FOS,IL6,JUN,LOX,NFIX,NR4A2,POLA2	 	
P1	 	Ige	 	complex	 	0.662	 	0.230	-0.145	1.31E-02	CCL2,CCL3,CCL3L3,CD86,CXCL2,CXCL8,FCER1A,FCER1G,HAVCR2,HDC,IL6,MYC,PTGS2	 	
P1	 	PELP1	0.459	other	 	1.414	 	0.134	1.036	1.31E-02	ADRB2,BMP2,COL12A1,DAB2,FOS,FYN,KAT2B,LEP,MMP2,MMP9,MYC,PSAT1,SRC	 	
P1	 	TRIM28	0.878	transcription regulator	 	0.469	bias	0.410	-0.749	1.31E-02	ALAD,ALAS2,EPAS1,ETS1,FECH,HMBS,IL6,KLF2,MMP2,NRXN2,RCAN1,S100A9,SOGA1	 	
P1	 	mir-15	-0.071	microrna	 	-1.281	bias	-0.376	-0.111	1.31E-02	CAPRIN1,CARM1,CCND2,CD69,FGF2,HMGA1,HSPA1A/HSPA1B,IL6,MCL1,MMP9,PTGS2,TIMP1,UCP2	 	
P1	 	melatonin	 	chemical - endogenous mammalian	 	0.727	 	-0.021	0.824	1.32E-02	ACACA,BMP2,CCL2,CXCL8,CYP11A1,DDAH2,EDN1,FOS,GJB2,HIF1A,HMOX1,HSPA9,IL6,IRS2,JUNB,LEP,MMP9,NQO1,PLAT,PTGS2,SOX9,SPARC,SPP1,SQSTM1	 	
P1	 	BRCA1	0.334	transcription regulator	 	0.366	 	0.172	-0.522	1.32E-02	AK1,ANGPT1,BCL2L1,COL18A1,CTSD,CYP1B1,DDIT3,DDIT4,EGR1,ENPP2,ESR1,GADD45A,GADD45B,GDF15,H3F3A/H3F3B,HMOX1,HSD11B2,IFI27,IFIT2,LPIN1,MYC,NEDD9,NQO1,PCBP2,PERP,PHLDA1,PIN1,PLTP,POLR3E,RRM2B,SERPINE2,STC1,UBE2I	 	
P1	 	CXCL8	-1.953	cytokine	 	0.504	 	0.198	-0.221	1.35E-02	BCL2L1,CD69,COL12A1,COL18A1,CXCL2,CXCL8,IFRD1,ITGA1,ITGAM,MMP2,MMP9,NFKBIA,PTGS2,TNFRSF10B,TPM1,VCAM1,ZFP36	 	
P1	 	LCN2	-0.071	transporter	 	0.246	bias	0.284	-0.835	1.35E-02	ACTN1,ATF5,BMP2,CAPG,CCL3L3,CDH2,COL1A1,CXCL2,ESR1,HIF1A,HMOX1,IL6,LDLR,MMP2,TINAGL1	 	
P1	 	candesartan	 	chemical drug	 	-0.048	bias	-0.387	1.274	1.37E-02	ACTA1,ADM,AGT,COL1A2,COL3A1,FOS,GFPT1,IL6,LEP,NPR3,POMC,SPP1	 	
P1	 	ACKR3	0.290	g-protein coupled receptor	 	 	 	 	 	1.38E-02	ADM,AKR1C3,AXL,CDK4,CXCL12,CXCR4,ELN,HBEGF	 	
P1	 	GRP	-0.083	growth factor	 	-1.761	bias	0.418	-2.912	1.38E-02	CXCL8,ELK1,FOS,FOSB,JUN,MYC,MYCN,PTGS2	 	
P1	 	NCOR-LXR-Oxysterol-RXR-9 cis RA	 	complex	 	1.463	bias	0.381	0.391	1.38E-02	ABCG1,ACACA,APOC1,APOE,ARG2,CD36,CYP51A1,PLTP	 	
P1	 	alpha-tocopherol	 	chemical drug	 	0.614	bias	-0.301	1.442	1.38E-02	ADIPOQ,CD36,CTGF,HMOX1,HSPA1A/HSPA1B,IL6,LEP,SQSTM1	 	
P1	 	epoxomicin	 	chemical - protease inhibitor	 	0.884	bias	0.449	-0.256	1.38E-02	CXCL8,DDIT3,H2AFZ,HSPA5,IRS2,NOX4,PSMB5,SQSTM1	 	
P1	 	kaempferol	 	chemical toxicant	 	1.109	bias	-0.290	1.754	1.38E-02	BCL2L1,CD69,HMOX1,JUN,MMP2,MMP9,PTGS2,SELE	 	
P1	 	A2M	0.239	transporter	 	1.364	bias	0.296	0.447	1.42E-02	ACLY,ATF4,ATF6,CDH2,DDIT3,ERN1,GADD45B,GAP43,GSK3B,HSPA5,PPP1R15A	 	
P1	 	OLR1	-0.188	transmembrane receptor	 	0.444	bias	0.373	-0.781	1.42E-02	CCL2,CD68,CYBA,IL6,ITGAM,NCF2,NOX4,SPP1,TGFBR2,TGFBR3,VCAM1	 	
P1	 	14,15-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-0.937	 	0.100	-1.156	1.42E-02	ADIPOQ,CTSK,FGF2,MMP9,NME1,PLAT	 	
P1	 	CFB	0.526	peptidase	 	0.640	bias	0.439	-0.427	1.42E-02	C5AR1,CXCL2,DDIT3,HSPA5,ITGAM,THBD	 	
P1	 	CYP2J2	0.019	enzyme	 	-0.034	 	0.167	-0.434	1.42E-02	BCL2L1,MMP9,NFKBIA,NME1,SELE,VCAM1	 	
P1	 	GC-GCR dimer	 	complex	 	-0.970	bias	0.501	 	1.42E-02	ADRB2,AGT,CD163,CDKN1C,DUSP1,NFKBIA	 	
P1	 	MEL T1	 	chemical - kinase inhibitor	 	0.816	 	0.063	0.663	1.42E-02	ATP5D,C1QBP,COPS8,ENO1,GLOD4,HSPA1A/HSPA1B	 	
P1	 	PD173074	 	chemical reagent	 	-0.861	 	-0.125	-0.559	1.42E-02	BCL2L1,CCL3,CCND2,CDK4,FRMD3,MYC	 	
P1	 	mir-221	-0.185	microrna	 	0.838	bias	-0.313	1.596	1.42E-02	CDKN1C,KDR,KIT,MEOX2,MMP2,MMP9	 	
P1	 	plumbagin	 	chemical toxicant	 	-0.555	 	-0.100	-0.332	1.42E-02	BCL2L1,ESR1,GSK3B,IL6,PRKCE,TNFRSF10B	 	
P1	 	SHH	0.051	peptidase	 	-0.545	bias	0.338	-2.090	1.42E-02	ADAMTS1,ALAD,ANGPT1,ATF5,BMP2,BMP4,CAV1,CCND2,CCNG2,CD69,CTPS1,DAAM1,GPC1,HEY1,HEY2,HMGA1,ID1,IL6,IMPDH2,MCM2,MYC,MYCN,PLAT,PMP22,PVR,PYCR2,SFRP1,SFRP2,SOX9,SPP1,SRM,THBD,TJP1,UNG	 	
P1	 	HSF2	-0.123	transcription regulator	Activated	2.619	bias	0.301	1.831	1.44E-02	CCT3,CCT5,CCT8,HIF1A,HSPA1A/HSPA1B,HSPA4,LHCGR,RELN,TXN	 	
P1	 	NPPB	0.007	other	Inhibited	-2.376	bias	-0.401	-1.185	1.44E-02	ACAT2,COL1A1,COL3A1,CTGF,HMGCS1,LDLR,LSS,MSMO1,SMAD7	 	
P1	 	Nuclear factor 1	 	group	 	1.539	 	0.201	1.101	1.44E-02	ADRA1B,ALDOA,COL1A1,DDIT3,GSS,HSD11B2,ID1,LOX,SERPINA3	 	
P1	 	PRKG1	-0.043	kinase	 	0.213	 	-0.060	0.393	1.44E-02	COL1A1,COL3A1,CTGF,FOS,GUCY1A3,HINT1,TAGLN,THBS1,VCAM1	 	
P1	 	UPF2	-0.227	other	 	-0.103	bias	-0.267	0.693	1.44E-02	HEY1,KANK1,NEO1,NRP1,PTGS2,RCAN1,RERGL,TNFAIP3,TSPAN13	 	
P1	 	SN-38	 	chemical drug	 	0.373	bias	0.371	-0.594	1.44E-02	BCL2L1,BIRC3,BMP6,ERBB2,GDF15,GNG11,MCL1,MYC,PPRC1,TNFRSF10B	 	
P1	 	MAP2K4	0.301	kinase	 	-1.702	bias	0.440	-3.138	1.45E-02	ATF3,BCL2L1,BIRC3,CD86,CXCL8,FLNA,FOS,GADD45A,IL6,JUN,KIF2A,PLA2G4A,PTGS2,TUBB2A	 	
P1	 	SIRT6	0.130	enzyme	 	-1.362	 	-0.201	-0.781	1.45E-02	ACSL3,ACSL4,BIRC3,CXCL8,DBP,ELOVL6,GSK3B,IGF2R,IL6,IRS2,LSS,PCBP2,PTGS2,RPL6	 	
P1	 	Gsk3	 	group	 	0.982	 	0.210	0.185	1.46E-02	ATF4,CXCL8,DDIT3,ESR1,FOS,FSCN1,GDF15,HIF1A,IL6,JUN,LDLR,MYC,PTGS2,SPP1,TNFAIP3,TNFRSF10B	 	
P1	 	TCF4	-0.114	transcription regulator	 	-1.629	bias	0.301	-2.511	1.46E-02	AMHR2,AXIN2,CD24,CDKN1C,CDKN2B,EDN1,FOS,JUN,MIA,MYC,POMC,SGK1,SOX9,SPP1,SQSTM1,VCAN	 	
P1	 	ATF5	3.407	transcription regulator	 	 	 	 	 	1.46E-02	ID1,MCL1,SAA1,SAA2	 	
P1	 	HBP1	-0.315	transcription regulator	 	0.000	bias	-0.376	0.745	1.46E-02	CTSB,H1F0,MYCN,PTGS2	 	
P1	 	L1CAM	0.055	other	Activated	2.000	bias	0.501	 	1.46E-02	ARHGDIA,MMP2,MMP9,SQLE	 	
P1	 	MIA	0.512	other	 	 	 	 	 	1.46E-02	CDH2,MIA,PLAT,SPARC	 	
P1	 	MMP8	0.101	peptidase	 	 	 	 	 	1.46E-02	CCL3L3,CXCL8,IL6,S100A8	 	
P1	 	N-propyl bromide	 	chemical reagent	Activated	2.000	bias	0.501	 	1.46E-02	GCLM,GSR,HMOX1,NQO1	 	
P1	 	PD 168393	 	chemical - kinase inhibitor	 	0.702	 	0.000	0.702	1.46E-02	CCL2,CXCL8,MCL1,RGS16	 	
P1	 	PNPLA8	-0.405	enzyme	 	0.422	 	0.000	0.422	1.46E-02	HMOX1,HSPA5,NQO1,PLA2G2A	 	
P1	 	RAB1A	0.157	enzyme	 	 	 	 	 	1.46E-02	ADRA1A,ADRA1B,ADRB2,PRKCD	 	
P1	 	RNF40	0.453	enzyme	 	1.000	bias	0.501	 	1.46E-02	ALPL,CXCL12,G6PD,PDK4	 	
P1	 	RP 73401	 	chemical toxicant	 	 	 	 	 	1.46E-02	BTG2,CXCL2,EGR1,RARA	 	
P1	 	SH3KBP1	0.256	other	 	0.000	bias	-0.251	0.501	1.46E-02	BCL2L1,CCND2,HIF1A,MYC	 	
P1	 	SOX17	-1.703	transcription regulator	 	 	 	 	 	1.46E-02	AXIN2,CDC42BPB,FOS,KDR	 	
P1	 	capsazepine	 	chemical toxicant	 	1.969	bias	-0.251	2.462	1.46E-02	CXCL8,FOS,PTGS2,TNFRSF10B	 	
P1	 	cordycepin	 	chemical drug	 	 	 	 	 	1.46E-02	ADORA1,ESR1,FOS,MYC	 	
P1	 	meldonium	 	chemical drug	 	1.000	bias	0.501	 	1.46E-02	CD36,GOT2,HADHA,LDLR	 	
P1	 	nilotinib	 	chemical drug	 	-0.957	bias	-0.251	-0.457	1.46E-02	BCL2L1,COL1A1,COL1A2,MYC	 	
P1	 	orlistat	 	chemical drug	 	0.000	 	0.125	-0.251	1.46E-02	APOB,CCL2,CCL3L3,CXCL8	 	
P1	 	polymyxin B	 	biologic drug	 	0.152	bias	-0.376	0.898	1.46E-02	CXCL8,IL6,LDLR,VCAM1	 	
P1	 	ponesimod	 	chemical drug	Inhibited	-2.000	bias	0.501	 	1.46E-02	CCL2,CTGF,IL6,THBS1	 	
P1	 	sphingosylphosphocholine	 	chemical - endogenous non-mammalian	 	-1.944	bias	0.376	-2.675	1.46E-02	CCL2,FOS,JUN,TGM2	 	
P1	 	FBXO32	0.204	enzyme	Activated	2.926	 	0.119	2.411	1.48E-02	ADSSL1,ALDH1A3,AXIN2,BCAT2,CCND2,CXCL2,GADD45A,GMPPB,HSPA5,HSPB7,HYOU1,IL6,ITGA3,LBP,MYCN,PTGIS,PTGS2,PYCR1,TFPI2	 	
P1	 	BCR (complex)	 	complex	 	0.010	bias	0.287	-1.290	1.48E-02	BCL2L1,BTK,CCL3,CCND2,CCND3,CCNG2,CD1C,CD69,CD86,CDK4,CXCR4,EGR1,FCER2,FOS,FOSB,HSPA5,IGSF1,JUNB,KLF4,KLF9,MCL1,MYC,PLA2G5,PTGS2,S1PR1	 	
P1	 	let-7	-0.359	microrna	 	-0.415	bias	-0.473	2.029	1.48E-02	ACVR1C,BCL2L1,BTG2,CDC16,CDC20,CDC34,CDCA5,CDH2,CEBPD,COL1A1,COL1A2,COL3A1,CPED1,FARP1,GPX7,IL6,IRS2,ITGA1,MCM2,MYC,MYCN,PTGS2,RCAN1,SIGMAR1,SOX9,STARD13,THBS1,TRIB1,ZFP36	 	
P1	 	FOXF1	-0.024	transcription regulator	 	-1.057	bias	0.501	 	1.53E-02	ACTG2,FGF2,MYH11,MYLK,VCAM1	 	
P1	 	Il8r	 	group	 	1.477	bias	0.418	0.551	1.53E-02	BCL2L1,CXCL8,ITGAM,MMP2,MMP9	 	
P1	 	MAML1	-0.088	transcription regulator	Inhibited	-2.219	bias	0.410	-3.129	1.53E-02	EGR1,HEY1,HEY2,HEYL,MYLK	 	
P1	 	N,N-dimethylsphingosine	 	chemical reagent	 	1.172	bias	-0.418	2.097	1.53E-02	FOS,IL6,PTGS2,SELE,VCAM1	 	
P1	 	PDCD4	-0.553	other	 	1.387	bias	-0.418	2.314	1.53E-02	IL6,JUN,PDCD4,PTGS2,VEGFC	 	
P1	 	RALA	1.011	enzyme	 	1.000	bias	0.319	0.362	1.53E-02	CD24,CDH2,MMP2,MMP9,PLAUR	 	
P1	 	SR 144528	 	chemical reagent	Activated	2.176	bias	-0.251	2.721	1.53E-02	CCL2,CCR1,CXCL8,EGR1,NFKBIA	 	
P1	 	STAR	0.055	transporter	 	-1.000	bias	-0.501	 	1.53E-02	ABCG1,CD36,CD86,POMC,SPP1	 	
P1	 	TFF3	-1.013	other	 	-0.313	 	0.056	-0.421	1.53E-02	CD55,CTSK,FOS,HIF1A,TJP1	 	
P1	 	TIMP3	0.184	other	 	-0.391	 	-0.228	0.114	1.53E-02	IL6,KIT,LRP8,MMP2,MMP9	 	
P1	 	VCP	0.450	enzyme	 	 	 	 	 	1.53E-02	CCL2,CXCL8,DDIT3,HSPA5,VCAM1	 	
P1	 	dimethyl fumarate	 	chemical drug	 	1.446	 	-0.056	1.569	1.53E-02	HMOX1,JUN,KDR,PTGS2,SELE	 	
P1	 	indinavir	 	chemical drug	 	0.277	 	-0.084	0.463	1.53E-02	ADIPOQ,CCL3,CD36,LIPE,MMP9	 	
P1	 	rhein	 	chemical - endogenous non-mammalian	 	-1.387	 	0.000	-1.387	1.53E-02	BCL2L1,CCR1,CXCL8,TJP1,VCAM1	 	
P1	 	tetrathiomolybdate	 	chemical drug	Inhibited	-2.236	bias	-0.334	-1.489	1.53E-02	COL1A1,ITGAM,MMP9,TIMP1,VCAM1	 	
P1	 	FSHR	0.059	g-protein coupled receptor	 	-0.274	bias	0.301	-1.059	1.54E-02	ADIPOQ,ADIPOR2,CD55,CYP11A1,DUSP1,GDE1,IGFBP3,INHBB,LHCGR,NPR3,PLAT,PPP1CB,TJP1	 	
P1	 	PTPN1	-0.007	phosphatase	 	1.087	 	-0.139	1.562	1.54E-02	ADRA1A,ADRA1B,CIDEA,CXCL2,DUSP1,EDEM1,IRS2,LEP,MARCO,NFKBIA,NOX4,RILPL1,SMAD7	 	
P1	 	salicylic acid	 	chemical drug	 	0.611	 	-0.203	1.300	1.54E-02	BCL2L1,CCL3,CTGF,CXCL8,DDIT3,FCER2,GDF15,HIF1A,IL6,MCL1,MMP9,PTGS2,TNFSF10	 	
P1	 	ETS2	-0.530	transcription regulator	 	0.768	bias	0.421	-0.785	1.57E-02	BCL2L1,BMP4,CSF1R,CYP27A1,ERBB2,FOS,GSK3B,HMOX1,JUN,JUNB,LYZ,MMP9,MYC,SPP1,TGFBR2	 	
P1	 	MDM2	-0.199	transcription regulator	 	1.989	 	0.019	1.922	1.57E-02	CDK4,CLIP3,CXCL8,ETS1,FCGRT,HIF1A,HIPK2,HIST2H2AA3/HIST2H2AA4,IGFBP6,INHBB,KAT2B,LYZ,MYCN,TIMP1,TNFSF10	 	
P1	 	peptidoglycan	 	chemical - endogenous non-mammalian	Inhibited	-2.661	bias	0.391	-4.445	1.59E-02	ATP6V0A2,CCL13,CCL18,CCL2,CCL3,CCL3L3,CCL8,CD86,CXCL16,CXCL2,CXCL8,DUSP1,EGR1,FOS,HMOX1,IL6,JUNB,MCL1,NLRP3,PTGS2,S100A8,S100A9	 	
P1	 	CDKN2A	0.205	transcription regulator	 	-0.496	 	-0.042	-0.232	1.62E-02	AK1,BTG2,BTG3,CAPG,CCL2,CCL3L3,CCND3,CDCA5,CDKN2B,CDKN2C,CEBPD,CPA4,CTGF,CXCL14,DUSP1,EBF1,EGR1,FAM86B1,FBL,FOS,FST,GABARAP,GFRA2,GLB1,GNL3,GSPT1,GTF3C1,HACD3,IL6,JUN,MCL1,MMP2,MYC,MYCN,ODC1,P4HA2,PBX3,PMEPA1,POLD2,PTX3,RRM2B,SERTAD1,SOX17,TMEM97,TOB1,TPM1,TPP1,TRIM28,ZMAT3	 	
P1	 	CpG oligonucleotide	 	chemical drug	 	-1.491	bias	0.376	-3.327	1.64E-02	BIRC7,C2,CASP4,CCL3L3,CCR1,CD14,CD36,CD86,CXCL2,CXCL8,EGR1,ETS2,FCGRT,IDO1,IFI27,IL6,LYN,MARCO,MCL1,MYC,NFKBIZ,NOTCH1,PRKCD,PTGS2,THBS1,TNFSF10	 	
P1	 	HSPA9	1.181	other	 	1.673	bias	0.351	0.750	1.65E-02	CLMN,CRABP2,MYC,MYCN,NEDD9,RET,SESN2	 	
P1	 	NCL	0.564	other	 	0.447	 	-0.116	0.706	1.65E-02	HIF1A,HSPA1A/HSPA1B,KLF2,MDK,MYC,PDCD4,RET	 	
P1	 	Tnf receptor	 	group	 	-0.378	bias	0.251	-1.041	1.65E-02	CTGF,CXCL8,ELANE,IL6,MMP9,SELE,TIMP1	 	
P1	 	DCAF1	0.087	kinase	 	1.818	bias	-0.501	 	1.65E-02	BMF,LOC102724428/SIK1,SOCS2,SOCS3,TGM2,TNFSF10,TOB1	 	
P1	 	nickel	 	chemical toxicant	 	1.912	bias	0.343	1.010	1.65E-02	CD86,CXCL8,ESR1,FGF2,GAPDH,HIF1A,PLAT	 	
P1	 	probucol	 	chemical drug	 	-1.633	 	-0.167	-1.224	1.65E-02	BMP2,CTGF,CYBA,HMOX1,PSMA3,PSMA4,VCAM1	 	
P1	 	FADD	0.273	other	Activated	2.047	bias	0.254	0.976	1.67E-02	BIRC3,CCND2,CXCL2,CXCL8,CXCR4,EGR1,FOS,GADD45B,IFIT2,IL6,JUN,JUNB,KLF6,LY6E,MMP9,MYC,PPP1R15A,TIPARP,TNFAIP3	 	
P1	 	Bay 11-7082	 	chemical - kinase inhibitor	 	0.714	bias	-0.484	2.410	1.69E-02	BCL2L1,BMP2,CCL2,CCL3L3,CXCL2,CXCL8,HMOX1,HSPA5,IL6,MCL1,MMP2,MMP9,PTGS2,TNFSF10	 	
P1	 	GNRH1	0.249	other	 	-1.881	 	0.237	-2.721	1.69E-02	CYP11A1,EGR1,EGR2,FOS,FOSB,FST,INHBB,JUN,JUNB,PLAT,PRKCD,PRKCE,PTGS2,RPLP1	 	
P1	 	KDR	-0.527	kinase	 	0.000	bias	0.376	-0.921	1.71E-02	BTK,EPHB3,HAVCR2,HMOX1,KDR,NME1,NOTCH1,PTGS2,SELE,SFRP1,TJP1	 	
P1	 	mir-21	-1.022	microrna	 	1.274	bias	-0.259	2.655	1.72E-02	BTG2,C1R,CASP4,CCL2,CCL3L3,CDH5,COL1A1,COL3A1,CSF3R,DBP,DDAH2,EGR2,ELN,IDO1,IL6,IRAK1,LEPR,MARCO,MMP2,MMP9,NLRP3,NPAS2,PDCD4,PLAT,PSME2,RHOB,SMAD7,SPRY1,SPRY2,TPM1,TYMP,VCAM1	 	
P1	 	cyclophosphamide	 	chemical drug	 	-0.458	bias	0.274	-1.526	1.76E-02	ATF3,CAPN6,CAT,FOS,GAP43,IER3,IL6,MYC,NGF,ODC1,SLC22A5,SOX9,SPP1,THBS1,TIMP1,TNFRSF12A,UPP1	 	
P1	 	ADAMTS12	0.004	peptidase	 	1.309	bias	-0.501	 	1.76E-02	ALDH1A3,HDC,IL6,MGP,S100A8,S100A9,SOX9,TAGLN	 	
P1	 	AHI1	0.344	other	 	0.707	 	-0.077	0.925	1.76E-02	BCAS4,BIN1,CCNG2,CDKN1C,LMCD1,PALM2,PDCD6,SV2B	 	
P1	 	ARRB1	0.105	other	 	1.000	 	0.029	0.941	1.76E-02	ADRB2,CXCL8,EGR1,IL6,JUNB,MYC,PTGS2,SPP1	 	
P1	 	UTP	 	chemical - endogenous mammalian	 	0.631	 	0.167	0.203	1.76E-02	CCL2,CD14,CDH2,FLNA,KCND2,SPP1,THBS1,VCAM1	 	
P1	 	alitretinoin	 	chemical drug	 	1.516	 	0.227	0.343	1.76E-02	ABCC3,ABCG1,ACADM,ANXA5,BCL2L1,CASP4,CCL8,CCND3,CD14,CD36,CD86,CDK4,CIDEA,CYP4F11,DHRS9,DNASE1L3,DUSP1,ESR1,FOLR2,FOS,IL6,ITGAM,MMP9,PLA2G15,PLTP,PTGIS,RARA,SLC27A1,SPP1,WNT5B	 	
P1	 	cardiotoxin	 	chemical - other	 	-0.277	bias	0.501	 	1.76E-02	AOC3,APRT,C5AR1,CAPN6,CCL2,CCL3L3,CCND2,CCND3,CCR1,COL1A2,COL6A2,CSF1R,CSF3R,CXCR4,DOK2,FBL,G6PD,GM2A,H19,HSPA5,IL10RA,KPNA2,MCM2,MMP2,SFRP2,SPP1,TIMP1,TSC22D1,TXNRD1,UCP2	 	
P1	 	NR2F1	-0.105	ligand-dependent nuclear receptor	 	1.132	 	0.072	0.947	1.76E-02	ACADM,AGT,ALDH2,EGR1,GDF15,LHCGR,POMC,SLC9A1,SPRY1,SPRY2	 	
P1	 	OGT	0.308	enzyme	 	0.000	 	0.017	-0.042	1.76E-02	ACADM,ACO2,ATP2A2,BCL2L1,FOS,JUN,MTX1,MYC,NDUFA9,TET1	 	
P1	 	mevalonic acid	 	chemical - endogenous mammalian	 	-0.167	 	0.084	-0.425	1.76E-02	CCL2,CD55,GNAI1,KLF2,LDLR,LEP,LHCGR,PLAT,PTGS2,VCAM1	 	
P1	 	pentoxifylline	 	chemical drug	 	-0.194	bias	-0.358	0.915	1.76E-02	BCL2L1,COL1A1,CTGF,FOS,IL6,NFKBIA,ORM1,TIMP1,TNFRSF10B,VCAM1	 	
P1	 	dopamine	 	chemical - endogenous mammalian	 	1.240	 	0.061	0.980	1.77E-02	BCL2L1,CLCN3,CTSK,CXCL8,DDIT3,EGR1,FOS,FST,GPC3,GUCY1A3,HMOX1,IL6,JUN,KCND2,LDLR,NPR3,PDE1B,POMC,PPP1R1B,RNLS,SLC1A3,TMEM205	 	
P1	 	TET2	-0.004	other	 	0.626	bias	0.306	-0.844	1.80E-02	AFF3,AHNAK,C5AR1,FAM129A,FAM129B,FLCN,FOXC1,GRK5,KLF2,LXN,MTSS1,NAV1,ORAOV1,PLS3,RGS1,RNF144A,S100A8,SERAC1,SLC20A1,SLC4A11,SORL1,TIMP1,TRIOBP,ZFP42	 	
P1	 	BCL2L1	0.717	other	 	0.149	 	0.032	0.039	1.81E-02	BCL2L1,COL6A2,CXCL8,GSR,ITGA3,MCL1,MMP9,NQO1,THBS1,TIMP1,TNFRSF10B,TNFRSF21,TNFSF10	 	
P1	 	NFKBIB	0.233	transcription regulator	 	-0.777	 	0.157	-1.249	1.81E-02	BCL2L1,CCL2,CD86,CXCL2,CXCL8,IL6,MMP9,NFKBIA,SELE,SMAD7,TEK,TNFSF10,VCAM1	 	
P1	 	RTN4	-1.260	other	 	-1.295	 	-0.023	-1.214	1.81E-02	ACTR1A,AP2A2,ARHGDIA,GAP43,GNG2,IL6,JUN,MAPRE3,MBP,NQO1,PEA15,RHOB,RTN4	 	
P1	 	colchicine	 	chemical drug	 	-1.308	 	0.146	-1.823	1.81E-02	ATF3,CTGF,CYP2C8,FOS,GAP43,HIF1A,JUN,LEP,MCL1,NGF,NQO1,PTGS2,SOX9	 	
P1	 	3,4-dihydroxyphenylethanol	 	chemical drug	 	 	 	 	 	1.81E-02	MMP9,PTGS2	 	
P1	 	3-hydroxyflavone	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	BCL2L1,HSPA1A/HSPA1B	 	
P1	 	3-iodobenzylguanidine	 	chemical drug	 	 	 	 	 	1.81E-02	MYC,MYCN	 	
P1	 	8-methyl-pyridoxatin	 	chemical reagent	 	 	 	 	 	1.81E-02	HIF1A,TF	 	
P1	 	ACPP	-0.040	phosphatase	 	 	 	 	 	1.81E-02	ERBB2,SHC1	 	
P1	 	ADI PEG20	 	biologic drug	 	 	 	 	 	1.81E-02	ASS1,MYC	 	
P1	 	AFAP1L2	-0.397	other	 	 	 	 	 	1.81E-02	CXCL8,IL6	 	
P1	 	AMOT	-0.390	other	 	 	 	 	 	1.81E-02	CTGF,CYR61	 	
P1	 	ASH1L	0.080	transcription regulator	 	 	 	 	 	1.81E-02	IL6,TNFAIP3	 	
P1	 	Alpha 1 antitrypsin	 	group	 	 	 	 	 	1.81E-02	CTSB,MMP2	 	
P1	 	BAY-u9773	 	chemical reagent	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	BR-4628	 	chemical reagent	 	 	 	 	 	1.81E-02	CTGF,LOX	 	
P1	 	BTBD7	0.390	other	 	 	 	 	 	1.81E-02	MMP2,MMP9	 	
P1	 	COL17A1	0.035	other	 	 	 	 	 	1.81E-02	CXCL8,IL6	 	
P1	 	CRADD	-0.380	other	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	DST	0.102	other	 	 	 	 	 	1.81E-02	DDIT3,HSPA5	 	
P1	 	E-4031	 	chemical drug	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	E. coli 011:B4 lipopolysaccharide	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	BCL2L1,ITSN1	 	
P1	 	E64	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	MMP2,TNFSF10	 	
P1	 	EIF2A	0.001	translation regulator	 	 	 	 	 	1.81E-02	ATF5,PCK2	 	
P1	 	EIF4F	 	complex	 	 	 	 	 	1.81E-02	MCL1,MYC	 	
P1	 	ETV7	0.041	transcription regulator	 	 	 	 	 	1.81E-02	BMP6,RARA	 	
P1	 	FAM103A1	0.281	other	 	 	 	 	 	1.81E-02	MYC,RUVBL1	 	
P1	 	FBXO25	0.095	enzyme	 	 	 	 	 	1.81E-02	EGR1,FOS	 	
P1	 	GNA14	0.036	enzyme	 	 	 	 	 	1.81E-02	CXCL8,IL6	 	
P1	 	GPR32	0.044	g-protein coupled receptor	 	 	 	 	 	1.81E-02	CXCL8,IL6	 	
P1	 	GSTK1	0.056	enzyme	 	 	 	 	 	1.81E-02	ADIPOQ,DDIT3	 	
P1	 	IBSP	-0.024	other	 	 	 	 	 	1.81E-02	MMP2,THBS1	 	
P1	 	IMPACT	0.111	other	 	 	 	 	 	1.81E-02	ATF4,DDIT3	 	
P1	 	KT 5926	 	chemical - kinase inhibitor	 	 	 	 	 	1.81E-02	CD14,VCAM1	 	
P1	 	LFM-A13	 	chemical - kinase inhibitor	 	 	 	 	 	1.81E-02	CCND2,HMOX1	 	
P1	 	NCEH1	-0.168	enzyme	 	 	 	 	 	1.81E-02	DDIT3,HSPA5	 	
P1	 	NEFL	0.021	other	 	 	 	 	 	1.81E-02	MYO5A,PRPH	 	
P1	 	NID1	-0.228	other	 	 	 	 	 	1.81E-02	NID2,PTPRF	 	
P1	 	NMB	0.457	other	 	 	 	 	 	1.81E-02	FOS,JUN	 	
P1	 	NPS	0.038	other	 	 	 	 	 	1.81E-02	FOS,ITGAM	 	
P1	 	NTN4	0.192	other	 	 	 	 	 	1.81E-02	CDH5,TJP1	 	
P1	 	NUBP1	-0.172	other	 	 	 	 	 	1.81E-02	FTH1,TFRC	 	
P1	 	OMG	0.061	g-protein coupled receptor	 	 	 	 	 	1.81E-02	FOS,MYC	 	
P1	 	PARM1	-1.272	other	 	 	 	 	 	1.81E-02	BMP2,BMP4	 	
P1	 	PLSCR3	0.412	enzyme	 	 	 	 	 	1.81E-02	ADIPOQ,LEP	 	
P1	 	PTPRT	0.575	phosphatase	 	 	 	 	 	1.81E-02	BCL2L1,SOCS3	 	
P1	 	RBMS3	-0.387	other	 	 	 	 	 	1.81E-02	CDK4,MYC	 	
P1	 	RYR3	-0.435	ion channel	 	 	 	 	 	1.81E-02	ADIPOQ,ATF3	 	
P1	 	Rab5	 	group	 	 	 	 	 	1.81E-02	ADRB2,IL6	 	
P1	 	S-adenosylhomocysteine	 	chemical - endogenous mammalian	 	 	 	 	 	1.81E-02	COL1A1,COL1A2	 	
P1	 	STAMBP	0.473	enzyme	 	 	 	 	 	1.81E-02	CXCR4,MYC	 	
P1	 	TAT	0.036	enzyme	 	 	 	 	 	1.81E-02	GLB1,MMP9	 	
P1	 	TMEM9B	0.526	other	 	 	 	 	 	1.81E-02	CXCL8,IL6	 	
P1	 	TPPP3	-0.693	other	 	 	 	 	 	1.81E-02	ADRB2,TPPP3	 	
P1	 	TXNDC5	0.432	enzyme	 	 	 	 	 	1.81E-02	CTSB,MMP9	 	
P1	 	VANGL1	0.071	other	 	 	 	 	 	1.81E-02	DVL2,JUN	 	
P1	 	ZHX2	0.737	transcription regulator	 	 	 	 	 	1.81E-02	HDC,MYH11	 	
P1	 	ZNF224	0.265	other	 	 	 	 	 	1.81E-02	ALDOA,TNFAIP3	 	
P1	 	ZNF350	-0.149	transcription regulator	 	 	 	 	 	1.81E-02	GADD45A,MMP9	 	
P1	 	amprenavir	 	chemical drug	 	 	 	 	 	1.81E-02	CD36,LEP	 	
P1	 	amsacrine	 	chemical drug	 	 	 	 	 	1.81E-02	JUN,MMP9	 	
P1	 	compound 48/80	 	chemical reagent	 	 	 	 	 	1.81E-02	IL6,LDLR	 	
P1	 	cortisone	 	chemical - endogenous mammalian	 	 	 	 	 	1.81E-02	IDO1,IL6	 	
P1	 	dioctyl adipate	 	chemical toxicant	 	 	 	 	 	1.81E-02	CD36,SLC27A1	 	
P1	 	dofetilide	 	chemical drug	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	hoechst 33342	 	chemical reagent	 	 	 	 	 	1.81E-02	FOS,SOX17	 	
P1	 	hydroxyl radical	 	chemical toxicant	 	 	 	 	 	1.81E-02	CAV1,KLF4	 	
P1	 	ingenol-dibenzoate	 	chemical reagent	 	 	 	 	 	1.81E-02	CD36,CD55	 	
P1	 	loganin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	CTGF,NOX4	 	
P1	 	metacept-1	 	chemical reagent	 	 	 	 	 	1.81E-02	BCL2L1,CDKN2B	 	
P1	 	miR-483-5p (miRNAs w/seed AGACGGG)	 	mature microrna	 	 	 	 	 	1.81E-02	ALCAM,ARHGDIA	 	
P1	 	miR-489-3p (miRNAs w/seed UGACAUC)	 	mature microrna	 	 	 	 	 	1.81E-02	GCA,PEX7	 	
P1	 	minalrestat	 	chemical drug	 	 	 	 	 	1.81E-02	FGF2,PRKCE	 	
P1	 	mir-346	0.048	microrna	 	 	 	 	 	1.81E-02	BTK,EFEMP2	 	
P1	 	oxazepam	 	chemical drug	 	 	 	 	 	1.81E-02	GADD45B,TSC22D1	 	
P1	 	polyinosinic acid	 	chemical reagent	 	 	 	 	 	1.81E-02	CCL2,VCAM1	 	
P1	 	retaspimycin	 	chemical drug	 	 	 	 	 	1.81E-02	ERBB2,KIT	 	
P1	 	sulfur	 	chemical - endogenous mammalian	 	 	 	 	 	1.81E-02	MMP2,MMP9	 	
P1	 	teleocidins	 	chemical toxicant	 	 	 	 	 	1.81E-02	FOS,ODC1	 	
P1	 	tetrahydropalmatine	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	CXCL8,PTGS2	 	
P1	 	tirapazamine	 	chemical drug	 	 	 	 	 	1.81E-02	RPA1,SPP1	 	
P1	 	titanium	 	chemical reagent	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	wax ester	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.81E-02	CCL2,IL6	 	
P1	 	IL33	0.143	cytokine	 	0.129	bias	0.309	-1.144	1.82E-02	ABCG1,ACAT1,ADAMTS1,ADRBK1,APOE,CCL18,CCL3,CD36,CD69,CD86,CXCL2,CXCL8,EGR2,IL6,ITGAM,LEPR,NFKBIA,PLIN2	 	
P1	 	KCNE3	0.101	ion channel	 	 	 	 	 	1.91E-02	AKR1C3,APOLD1,BAALC,COCH,CSRNP1,FOSB,HSPA1A/HSPA1B,JCHAIN,KCNJ2,KLF4,NR4A2,OSGIN1,PHLDA1,PTGS2,SLC2A5,VSIG4	 	
P1	 	AGPAT2	-0.269	enzyme	Inhibited	-2.433	 	-0.029	-2.361	1.95E-02	ACACA,ADIPOQ,ELOVL6,LEP,PLD3,PLIN1	 	
P1	 	Angiotensin II receptor type 1	 	group	 	-0.600	bias	0.435	-1.644	1.95E-02	CCL2,CCL3L3,CXCL8,EDN1,GAP43,TIMP1	 	
P1	 	C5	 	other	 	-1.791	bias	0.442	-2.858	1.95E-02	BCL2L1,C5AR1,CCL3L3,CXCL2,IL6,SOCS3	 	
P1	 	Endothelin	 	group	Inhibited	-2.364	bias	0.501	 	1.95E-02	ACTA1,EDN1,FOS,JUN,MYC,PTGS2	 	
P1	 	NCR2	0.003	transmembrane receptor	 	-0.728	bias	0.501	 	1.95E-02	NR4A2,NR4A3,PTGS2,RCAN1,THBS1,TYROBP	 	
P1	 	Smad2/3-Smad4	 	complex	 	-0.346	bias	0.442	-1.419	1.95E-02	CDKN2B,COL1A1,COL1A2,IGFBP3,MYC,SMAD7	 	
P1	 	T	0.177	transcription regulator	Activated	2.236	bias	0.501	 	1.95E-02	ALCAM,COL1A1,ITGA3,KDR,MGP,SOX9	 	
P1	 	TF	-1.096	transporter	 	0.816	bias	0.501	 	1.95E-02	CCL2,CCND3,COL1A1,CXCL8,ERP29,WDR5	 	
P1	 	arecoline	 	chemical drug	 	1.982	 	0.143	1.698	1.95E-02	ERBB2,HMOX1,IL6,MAOA,TJP1,VCAM1	 	
P1	 	calcipotriene	 	chemical drug	 	-0.000	 	0.147	-0.358	1.95E-02	CXCL8,FOS,JUN,JUNB,PRKCD,SPP1	 	
P1	 	indirubin	 	chemical drug	 	0.000	 	-0.188	0.461	1.95E-02	BCL2L1,BIRC3,CYR61,JUN,MMP9,MYC	 	
P1	 	isoliquiritigenin	 	chemical - endogenous non-mammalian	 	0.298	bias	-0.424	1.235	1.95E-02	CTGF,IL6,MMP2,MMP9,PTGS2,TGFBR2	 	
P1	 	mannitol	 	chemical - endogenous mammalian	 	-1.043	 	0.088	-1.254	1.95E-02	AKR1B1,AQP9,COL1A1,CTGF,HDC,JUN	 	
P1	 	p85 (pik3r)	 	group	 	-1.732	bias	0.270	-2.387	1.95E-02	HIF1A,IL6,MCL1,MMP2,NDRG1,PTGS2	 	
P1	 	peroxynitrite	 	chemical toxicant	 	-1.000	bias	0.251	-1.605	1.95E-02	CXCL8,DDIT3,FOS,IDO1,LMO4,LYN	 	
P1	 	FOXM1	0.314	transcription regulator	 	0.469	bias	0.426	-1.390	1.97E-02	ADAM17,AXIN2,CAV1,CCND2,CDC20,CDH2,CENPB,CXCL12,ESR1,GLB1,HSD11B2,IL6,KDR,LOX,MMP2,MMP9,MYC,PLAUR,SFTPD,TGFBR2,TJP1,VCAN	 	
P1	 	NCOA1	0.360	transcription regulator	 	0.382	 	0.026	0.274	1.97E-02	--,ADIPOQ,CD24,CYP11A1,DDX28,DGKQ,FGF2,GJB2,IL6,KDR,LEP,LYZ,MAPK8IP2,MTHFSD,MYC,NCAPH2,NFKBIA,NFKBIZ,PAWR,SORBS1,THRSP,TLE1	 	
P1	 	1,2,3,4,6,7,8-heptachlorodibenzofuran	 	chemical toxicant	 	 	 	 	 	1.97E-02	COMT,CYP1B1,ESR1	 	
P1	 	2,3,7,8-tetrachlorodibenzofuran	 	chemical toxicant	 	 	 	 	 	1.97E-02	COMT,CYP1B1,ESR1	 	
P1	 	ADAM9	0.031	peptidase	 	 	 	 	 	1.97E-02	ITGA3,SLIT2,TIMP1	 	
P1	 	CREB3L4	0.097	transcription regulator	 	 	 	 	 	1.97E-02	ANG,AQP9,KDELR3	 	
P1	 	Ctnna	 	group	 	 	 	 	 	1.97E-02	AXIN2,CXCR4,SOX17	 	
P1	 	ENTPD5	0.193	enzyme	 	 	 	 	 	1.97E-02	COL1A1,COL1A2,PRKCD	 	
P1	 	FUT7	-0.067	enzyme	 	 	 	 	 	1.97E-02	CD24,GLG1,SELE	 	
P1	 	G6PC	0.070	phosphatase	 	 	 	 	 	1.97E-02	CYP11A1,HSPA5,HYOU1	 	
P1	 	GTF2H4	0.490	transcription regulator	 	 	 	 	 	1.97E-02	CCND2,CDK4,NCL	 	
P1	 	Gpcr	 	group	 	 	 	 	 	1.97E-02	FOS,JUN,RGS1	 	
P1	 	HTR4	0.066	g-protein coupled receptor	 	 	 	 	 	1.97E-02	ANGPT1,CXCL12,VCAM1	 	
P1	 	KIDINS220	-0.195	transcription regulator	 	 	 	 	 	1.97E-02	CD69,EGR1,FOS	 	
P1	 	MKX	1.186	transcription regulator	 	 	 	 	 	1.97E-02	COL1A1,COL1A2,TNMD	 	
P1	 	MNK1/2	 	group	 	 	 	 	 	1.97E-02	MYC,SPRY1,SPRY2	 	
P1	 	NCK2	0.325	kinase	 	 	 	 	 	1.97E-02	ATF4,DDIT3,PPP1R15A	 	
P1	 	NUBPL	0.012	other	 	 	 	 	 	1.97E-02	NDUFA13,NDUFS3,NDUFV1	 	
P1	 	PADI4	-1.331	enzyme	 	 	 	 	 	1.97E-02	BCL2L1,GADD45A,OSGIN1	 	
P1	 	PSAP	0.205	other	 	 	 	 	 	1.97E-02	BIRC3,ESR1,GBA	 	
P1	 	RHOC	0.049	enzyme	 	 	 	 	 	1.97E-02	ATF3,CDKN1C,DDIT3	 	
P1	 	SEMA3F	0.022	other	 	 	 	 	 	1.97E-02	HIF1A,MMP2,MMP9	 	
P1	 	SPRY4	0.109	other	 	 	 	 	 	1.97E-02	CNN1,ETV5,TAGLN	 	
P1	 	WRN	0.224	enzyme	 	 	 	 	 	1.97E-02	CXCL8,HIF1A,PRKCD	 	
P1	 	YY2	0.039	other	 	 	 	 	 	1.97E-02	CXCR4,FOS,MYC	 	
P1	 	ZMIZ2	0.104	transcription regulator	 	 	 	 	 	1.97E-02	AXIN2,JUN,MYC	 	
P1	 	allosamidin	 	chemical reagent	 	 	 	 	 	1.97E-02	ABCG1,CCL2,CD36	 	
P1	 	apamin	 	chemical toxicant	 	 	 	 	 	1.97E-02	FOS,JUN,VCAM1	 	
P1	 	betulin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.97E-02	BCL2L1,PTGS2,TIMP1	 	
P1	 	butylated hydroxytoluene	 	chemical toxicant	 	 	 	 	 	1.97E-02	FOS,JUN,PTGS2	 	
P1	 	enzastaurin	 	chemical drug	 	 	 	 	 	1.97E-02	CLDN5,TJP1,TNFRSF10B	 	
P1	 	ghrelin	 	biologic drug	 	 	 	 	 	1.97E-02	ACACA,EGR1,FOS	 	
P1	 	heparan sulfate	 	chemical - endogenous mammalian	 	 	 	 	 	1.97E-02	FGF2,IL6,PRNP	 	
P1	 	luminespib	 	chemical drug	 	 	 	 	 	1.97E-02	BCL2L1,ERBB2,HSPA1A/HSPA1B	 	
P1	 	quisqualic acid	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.97E-02	EGR1,FOS,JUNB	 	
P1	 	CCL2	-1.732	cytokine	 	-0.010	 	0.206	-0.806	1.99E-02	ABCG1,CCL2,CD86,CXCL8,FOLR2,FOS,HDC,IL6,ITGA1,MMP2,MMP9,NOTCH1,PTGDS,PTGS2,SLC11A1,TIMP1,VCAM1	 	
P1	 	BBI608	 	chemical drug	 	0.410	bias	-0.501	 	2.08E-02	ALCAM,ALDH1A1,AXL,CD24,CXCL8,ERBB2,GSK3B,ID1,KLF4,MYC,NOTCH1,PLAUR,RPLP0,SMO,TAZ	 	
P1	 	entinostat	 	chemical drug	 	0.137	 	0.059	-0.071	2.08E-02	BCL2L1,CSF2RA,DUSP1,ERBB2,IGFBP3,ITGAM,LYVE1,MCL1,MMP2,MMP9,TGFBR2,TNFRSF10B,TNFRSF19,TNFSF10,TXN	 	
P1	 	miR-155-5p (miRNAs w/seed UAAUGCU)	 	mature microrna	 	-0.799	bias	-0.501	 	2.09E-02	CCL18,CCL3,CD209,CD69,CSF1R,CXCL2,CXCL8,CYP51A1,CYR61,DPP7,DSG2,ETS1,FCER2,HSDL1,IL6,LCLAT1,LDOC1,MAF,MYO10,NARS,PELI1,RAB34,SDCBP,SH3BP4,SPI1,TBCA,TM6SF1,TXNDC12,TXNRD1,WDFY1	 	
P1	 	EOMES	0.138	transcription regulator	 	-0.792	 	0.019	-0.859	2.11E-02	AFAP1,BHLHE22,CRABP1,CRYM,CXCR4,DNAJC15,DUSP14,MESP1,SATB2,SV2B,TMEM2,TNFSF10,ZNF521	 	
P1	 	PIN1	0.500	enzyme	Inhibited	-2.144	 	0.110	-2.501	2.11E-02	BTK,COL3A1,EPB41L4B,IL6,MCL1,MMP2,MMP9,MYC,NFE2L1,PTGS2,TBC1D31,TIMP1,TIMP4	 	
P1	 	ADORA2B	0.277	g-protein coupled receptor	 	-0.128	 	0.177	-0.685	2.13E-02	CD86,COL1A2,CXCL2,CXCL8,HIF1A,IL6,KLF4,MMP9,SPP1,TIMP1	 	
P1	 	CUL4B	0.157	other	Inhibited	-2.449	bias	-0.301	-1.713	2.13E-02	AXIN2,HSPA9,IGFBP3,NKD2,NME1,PYGO2,RUNX1,TSC2,UBXN1,ZFP36	 	
P1	 	EGR3	-0.853	transcription regulator	 	-1.929	 	0.043	-2.064	2.13E-02	B3GALT6,BCL2L1,IRAK1,JUN,NOTCH1,RCCD1,RET,SLIT2,SOCS3,SOX9	 	
P1	 	anandamide	 	chemical - endogenous mammalian	 	0.305	 	0.167	-0.184	2.13E-02	ANGPTL4,FGF2,FOS,HSPA5,IL6,MMP2,NCSTN,PLIN2,PTGS2,STIP1	 	
P1	 	BMPR2	-0.264	kinase	 	-0.879	bias	0.313	-1.500	2.15E-02	CXCL12,CXCL8,EFNB2,ID1,SELE,SEMA3C,SPP1	 	
P1	 	CASP8	0.146	peptidase	 	-0.729	 	0.167	-1.135	2.15E-02	ADAM17,CD14,CD69,FOS,IL6,MMP9,NLRP3	 	
P1	 	DLL4	-0.353	other	 	-0.194	 	-0.046	-0.075	2.15E-02	EFNB2,HEY1,HEY2,KDR,LYVE1,MAF,UNC5B	 	
P1	 	GADD45A	0.905	other	 	1.709	 	-0.091	1.948	2.15E-02	BCL2L1,CXCL2,FOSB,IL6,JUN,MMP9,UCHL1	 	
P1	 	Ikb	 	group	 	0.714	bias	0.383	-0.126	2.15E-02	BCL2L1,CCL2,CFB,HSPA5,IL6,PTGS2,TNFAIP3	 	
P1	 	MED13	-0.059	transcription regulator	 	-1.134	bias	-0.501	 	2.15E-02	ACACA,CIDEA,CIDEC,ELN,ELOVL6,ENO1,THRSP	 	
P1	 	NOV	-0.357	growth factor	 	-0.896	 	-0.100	-0.678	2.15E-02	ALPL,BMP4,CCL2,COL1A1,CTGF,MMP2,MMP9	 	
P1	 	RNF31	0.051	enzyme	 	-0.378	bias	0.365	-1.343	2.15E-02	ADORA1,CXCR4,EGR3,ESR1,IGFBP4,KCNMA1,NR5A2	 	
P1	 	SFTPD	0.732	other	 	0.199	 	-0.150	0.555	2.15E-02	CCL2,CD14,CD209,CXCL2,MMP2,MMP9,SFTPD	 	
P1	 	beta-glycerophosphoric acid	 	chemical - endogenous mammalian	 	0.128	bias	0.310	-0.627	2.15E-02	ALPL,BMP2,MGP,PTGS2,SLC20A1,SPARC,SPP1	 	
P1	 	ceruletide	 	biologic drug	 	1.056	bias	0.351	0.142	2.15E-02	ATF4,CXCL2,DDIT3,HMOX1,HSPA5,MME,PTGS2	 	
P1	 	ilomastat	 	chemical drug	 	-0.374	 	-0.050	-0.264	2.15E-02	CCL2,CXCL8,F11R,HBEGF,MMP9,NGF,TJP1	 	
P1	 	piceatannol	 	chemical - endogenous non-mammalian	 	1.524	 	-0.185	1.968	2.15E-02	CCL2,HMOX1,IL6,MMP9,MYC,PTGS2,TNFRSF10B	 	
P1	 	sucrose	 	chemical - endogenous mammalian	 	-0.080	bias	0.270	-0.605	2.15E-02	APOE,CRYM,DDAH2,FOS,FOSB,IL6,LEP	 	
P1	 	ADA	0.379	enzyme	 	-1.325	bias	-0.458	-0.059	2.21E-02	ADORA1,COL1A2,CXCL2,HIF1A,IL6,MMP9,SPP1,TIMP1	 	
P1	 	REN	-0.011	peptidase	 	-0.145	 	0.153	-0.515	2.21E-02	AGT,CD86,COL3A1,CTGF,FGF2,FOS,IL6,NOX4	 	
P1	 	ceramide	 	chemical - endogenous mammalian	 	-1.929	 	0.167	-2.390	2.21E-02	COL1A1,CXCL8,FOS,GAPDH,JUN,MYC,PTGS2,SFRP1	 	
P1	 	choline fenofibrate	 	chemical drug	 	-1.135	 	0.084	-1.364	2.21E-02	ADIPOQ,CAV1,CXCL12,HIF1A,NFKBIA,NR1D1,PCSK5,PTPRF	 	
P1	 	diallyl disulfide	 	chemical - endogenous non-mammalian	 	1.537	bias	0.358	0.537	2.21E-02	ABCC3,ATF3,CD55,GDF15,GSR,GSTM5,HMOX1,NQO1	 	
P1	 	miR-22-3p (miRNAs w/seed AGCUGCC)	 	mature microrna	 	0.180	bias	-0.501	 	2.21E-02	AGBL5,BIN1,CHD7,CLIP2,CYTH3,ESR1,MECOM,MTHFD2	 	
P1	 	miR-26a-5p (and other miRNAs w/seed UCAAGUA)	 	mature microrna	 	-0.405	bias	-0.501	 	2.21E-02	CCND2,CCND3,CDK4,GSK3B,MYC,PLAG1,PTGS2,TGFBR2	 	
P1	 	prostaglandin D2	 	chemical - endogenous mammalian	 	-0.292	 	0.056	-0.444	2.21E-02	CCL3,CXCL8,HMOX1,HSPA1A/HSPA1B,IL6,ITGAM,PTGDS,PTGS2	 	
P1	 	LY96	0.677	transmembrane receptor	 	0.677	 	0.228	0.245	2.22E-02	CD86,CXCL2,CXCL8,IL6,SELE	 	
P1	 	MLX	0.280	transcription regulator	 	1.944	bias	0.501	 	2.22E-02	ACACA,ARRDC4,ELOVL6,MID1IP1,THRSP	 	
P1	 	SKF-38393	 	chemical reagent	 	0.092	bias	0.270	-0.499	2.22E-02	EGR1,FGF2,FOS,HSPA9,PRKCD	 	
P1	 	SP7	-0.029	transcription regulator	 	 	 	 	 	2.22E-02	ALPL,COL1A1,IL6,SATB2,SPP1	 	
P1	 	TOPBP1	0.041	other	 	-0.708	bias	-0.424	0.226	2.22E-02	ABL1,CDKN2B,COQ8A,GADD45A,IGFBP3	 	
P1	 	WDR5	0.698	other	 	 	 	 	 	2.22E-02	CDH2,ERBB2,ESR1,IGF2R,SPP1	 	
P1	 	alvespimycin	 	chemical drug	 	-0.593	bias	-0.270	0.006	2.22E-02	CDK4,ERBB2,ESR1,HSPA1A/HSPA1B,MCL1	 	
P1	 	formoterol	 	chemical drug	 	-1.981	 	-0.201	-1.583	2.22E-02	CDKN1C,IL6,MMP9,PSMA3,PSMA4	 	
P1	 	gamma-linolenic acid	 	chemical - endogenous mammalian	 	1.342	 	-0.039	1.428	2.22E-02	CCL2,HMOX1,PLIN2,PTGS2,THRSP	 	
P1	 	poly-L-lysine	 	chemical reagent	 	-1.342	bias	0.418	-2.276	2.22E-02	CCL2,COL1A2,CXCL8,IL6,ITGAM	 	
P1	 	spermine nitric oxide complex	 	chemical toxicant	 	-0.277	 	-0.193	0.151	2.22E-02	BCL2L1,CXCL8,HMOX1,SELE,VCAM1	 	
P1	 	Calcineurin protein(s)	 	complex	 	0.914	bias	0.289	-0.004	2.26E-02	ATP2A2,CAMK2D,CDK4,CYGB,DUSP1,DUSP14,EGR1,EGR2,FOS,NR4A2,NR4A3,PTGS2,RCAN1,SPP1	 	
P1	 	MBD2	-0.685	transcription regulator	 	-0.643	 	0.046	-0.762	2.26E-02	APOE,ATP5I,BCAT2,BIRC3,CDKN2B,CEL,ELANE,ESR1,G6PD,MGMT,MMP2,MMP9,NUPR1,RNASE1	 	
P1	 	1,1-bis(3'-indolyl)-1-(4-trifluoromethyl-phenyl)methane	 	chemical reagent	 	-0.849	bias	0.279	-1.400	2.35E-02	ATF3,CAV1,GDF15,TNFSF10	 	
P1	 	11-dehydrocorticosterone	 	chemical - endogenous mammalian	 	-1.982	 	0.167	-2.314	2.35E-02	ACACA,GPAM,LIPE,PDK4	 	
P1	 	8,9-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.000	bias	0.279	-1.557	2.35E-02	ADIPOQ,MMP9,NME1,PLAT	 	
P1	 	ATG16L1	0.269	enzyme	 	1.091	bias	-0.501	 	2.35E-02	CXCL2,IL6,NFKBIA,SQSTM1	 	
P1	 	C7	0.868	other	 	-1.000	bias	0.251	-1.501	2.35E-02	CCL3L3,CXCL2,SELE,VCAM1	 	
P1	 	C8	 	complex	 	-1.000	bias	0.251	-1.501	2.35E-02	CCL3L3,CXCL2,SELE,VCAM1	 	
P1	 	C9	-0.010	other	 	-1.000	bias	0.251	-1.501	2.35E-02	CCL3L3,CXCL2,SELE,VCAM1	 	
P1	 	CD209	1.702	other	 	1.000	 	0.167	0.666	2.35E-02	CCL3,CD209,CD86,PTGS2	 	
P1	 	FBXO42	0.122	other	 	0.132	bias	0.501	 	2.35E-02	CXCL8,IL6,MMP9,VCAM1	 	
P1	 	FGF3	0.059	growth factor	 	 	 	 	 	2.35E-02	MMP2,MMP9,PLAT,PNCK	 	
P1	 	GUSB	0.514	enzyme	 	 	 	 	 	2.35E-02	CEBPD,CYR61,EGR2,EXOC4	 	
P1	 	HTR7	-0.115	g-protein coupled receptor	 	-1.067	bias	0.501	 	2.35E-02	FOS,IL6,STAB1,THBS1	 	
P1	 	IREB2	0.042	translation regulator	 	-0.975	bias	-0.279	-0.425	2.35E-02	ACO2,ALAS2,FTH1,TFRC	 	
P1	 	L-lysine	 	chemical - endogenous mammalian	 	0.159	 	-0.056	0.268	2.35E-02	CXCL2,DDIT3,IL6,PCK2	 	
P1	 	LMO2	-0.288	transcription regulator	 	 	 	 	 	2.35E-02	ADGRG1,CDH5,EPB42,KIT	 	
P1	 	MCAM	0.502	other	 	1.956	 	0.056	1.847	2.35E-02	ATF3,CD24,ID1,MMP2	 	
P1	 	Mir218	 	microrna	 	1.177	 	0.056	1.067	2.35E-02	CXCR4,SFRP2,SPP1,TOB1	 	
P1	 	NEK6	0.344	kinase	 	-1.000	bias	0.501	 	2.35E-02	IL6,PTGS2,RGS1,RILPL1	 	
P1	 	NEK7	-0.841	kinase	 	1.000	bias	0.279	0.443	2.35E-02	EDN1,LMO4,PTGS2,RGCC	 	
P1	 	PNPT1	-0.079	enzyme	 	 	 	 	 	2.35E-02	BCL2L1,CXCL8,IL6,MYC	 	
P1	 	PTMA	0.111	other	 	 	 	 	 	2.35E-02	CCL3,CCL3L3,IDO1,MMP9	 	
P1	 	Pde	 	group	 	0.000	bias	-0.390	0.780	2.35E-02	FOS,HMOX1,NR4A2,NR4A3	 	
P1	 	R 59022	 	chemical - kinase inhibitor	 	1.000	 	-0.056	1.111	2.35E-02	CCL2,CD69,CXCL8,IL6	 	
P1	 	RALBP1	0.050	enzyme	 	 	 	 	 	2.35E-02	COL1A2,GAPDH,IL6,MMP2	 	
P1	 	SRY	0.048	transcription regulator	 	0.928	bias	0.501	 	2.35E-02	MAOA,PTGDS,SOX9,THOP1	 	
P1	 	TAF6	0.503	transcription regulator	 	 	 	 	 	2.35E-02	GADD45A,GAPDH,HOXA9,JUN	 	
P1	 	UACA	-0.380	other	 	-1.964	 	-0.167	-1.636	2.35E-02	CEBPD,DDIT3,HSPA5,IL6	 	
P1	 	UCN2	0.070	other	 	-1.941	 	0.125	-2.185	2.35E-02	CCL2,CXCL8,FOS,POMC	 	
P1	 	VEGFC	-0.776	growth factor	 	-1.949	bias	0.501	 	2.35E-02	CXCR4,KDR,PTGS2,VEGFC	 	
P1	 	Z-DEVD-FMK	 	chemical - protease inhibitor	 	-1.000	 	-0.056	-0.889	2.35E-02	BLMH,CXCL2,FCER1G,MCL1	 	
P1	 	arachidonyltrifluoromethane	 	chemical reagent	 	0.247	bias	-0.501	 	2.35E-02	PLA2G2A,PLA2G4A,PLA2G5,PTGS2	 	
P1	 	astressin 2B	 	biologic drug	 	-0.686	 	0.125	-0.901	2.35E-02	CXCL2,FOS,KCNMA1,SLC2A3	 	
P1	 	betaine	 	chemical - endogenous mammalian	 	-1.131	 	-0.125	-0.883	2.35E-02	CCL2,DDIT3,FGF2,HSPA5	 	
P1	 	cytochalasin B	 	chemical toxicant	 	 	 	 	 	2.35E-02	BMP2,MCAM,MMP2,MMP9	 	
P1	 	miR-224-5p (miRNAs w/seed AAGUCAC)	 	mature microrna	 	-1.165	bias	-0.501	 	2.35E-02	AP2M1,CXCL14,MMP9,PAK4	 	
P1	 	mir-515	0.116	microrna	 	1.990	bias	-0.501	 	2.35E-02	ANGPTL4,CXCL8,IL6,TGFBR2	 	
P1	 	saturated fatty acid	 	chemical - other	 	 	 	 	 	2.35E-02	CCL2,CCL3,IL6,PTGS2	 	
P1	 	theophylline	 	chemical drug	 	0.343	 	0.125	0.128	2.35E-02	CXCL8,FOS,IL6,THBD	 	
P1	 	thiocoraline	 	chemical reagent	 	-1.982	 	0.167	-2.314	2.35E-02	HES6,HEY1,HEY2,NOTCH1	 	
P1	 	PLAU	-0.102	peptidase	 	-1.694	 	0.222	-2.477	2.38E-02	ABCG1,ANG,BCL2L1,C5AR1,CCL2,CYR61,GDF15,HSPA5,IFNAR2,IL6,MMP9,PHLDA1,PLAUR,S100A8,S100A9	 	
P1	 	MAPK14	-0.093	kinase	Inhibited	-2.212	bias	0.333	-4.013	2.38E-02	ACP5,ACTA1,CAT,CCL2,CD86,CEBPD,COL1A1,CXCL8,CYP51A1,DUSP1,FOS,GADD45A,HMOX1,IL6,JUN,JUNB,KDR,LDLR,MMP9,MYH11,PIN1,PLA2G5,PLAUR,PTGS2,SGK1,SHC1,SOCS3,STIM1,TAGLN,TGM2,TIMP1,ZFP36	 	
P1	 	IL1RN	0.358	cytokine	 	1.325	bias	-0.377	3.172	2.40E-02	ATF3,CCL2,CHAC1,CXCL8,ERAP2,GBP1,H6PD,IFI27,IGFBP4,IL6,ISG20,KLF6,LAMP3,MMP9,NGF,PELI1,PTGS2,RARRES1,S100A9,SELE,SLC15A3,SPP1,TIMP1,TNFSF10,VEGFC	 	
P1	 	ATP	 	chemical - endogenous mammalian	 	-0.334	 	0.236	-1.364	2.41E-02	CD14,CXCL2,CXCL8,CXCR4,DLG4,DUSP1,FLNA,FOS,GCLM,HBEGF,IL6,ITGAM,MBP,MYC,NRP1,P2RX4,P2RX7,PTGS2,THBS1,TXN,VCAM1	 	
P1	 	CRP	0.085	other	 	1.765	 	0.203	1.240	2.41E-02	CCL2,CCL3L3,CXCL8,EGR1,F8,FCER1A,IL6,ITGAM,PSMB7,PSME2,TNFSF10	 	
P1	 	retinoid	 	chemical drug	 	1.500	 	0.150	1.009	2.41E-02	DUSP1,EDN1,FOLR2,GTF3A,HBEGF,IGFBP3,LIMA1,MYC,PTGS2,RARRES3,TNFSF10	 	
P1	 	oblimersen	 	biologic drug	 	-0.832	bias	0.464	-2.506	2.45E-02	ADM,ATF3,CEBPD,CXCL8,DUSP1,EFNB2,FLAD1,GADD45A,GADD45B,IFI27,IFRD1,N4BP1,ZPR1	 	
P1	 	TLR9	-0.000	transmembrane receptor	Inhibited	-2.951	bias	0.399	-5.351	2.54E-02	ARG2,ARRDC4,ATF3,CAST,CCL3,CCL3L3,CD69,CD86,CERS6,CXCL8,DUSP1,EDN1,EGR1,GADD45B,HMOX1,IDO1,IER3,IFIT2,IL10RA,IL6,ISG20,KDELR3,LAMP2,LIPG,NFKBIZ,NSMAF,PFKFB3,PHLDA1,PROCR,PTGS2,S100A8,SGPL1,SMPD1,SMPDL3A,SOCS3,SPRY1,SPTLC2,TIMP1,TNFSF10	 	
P1	 	mir-10	0.133	microrna	 	-1.895	bias	-0.352	-0.517	2.54E-02	ACVR1C,BCL2L1,BMF,CCL2,CD86,CTDSPL,CYR61,ERBB2,HDC,HIF1A,IL6,KLF4,MAF,MCL1,MKNK2,MTOR,SGPL1	 	
P1	 	spironolactone	 	chemical drug	 	0.480	 	-0.127	0.992	2.54E-02	ABCC3,ACACA,CIDEA,COL1A1,COL1A2,COL3A1,CTGF,CXCR4,EDN1,FGF2,IL6,KCNMA1,LOX,PTGS2,SLC9A1,SLCO2A1,SLCO2B1	 	
P1	 	n-nitrosomethylbenzylamine	 	chemical toxicant	 	 	 	 	 	2.57E-02	AHNAK,AKR1B10,ALDH3A2,AOX1,C21orf33/LOC102724023,CDK4,DUSP5,FST,GCLM,GSS,H2AFZ,HMOX1,IDH1,INHBB,LAMP2,LEPR,LRBA,MAP2K3,MCL1,MYO10,PECR,PLS3,PTGS2,RGS17,TMED2,TTC1,TXNL1	 	
P1	 	Fcer1	 	complex	 	-1.434	bias	0.430	-2.886	2.59E-02	ATP2A2,CCL2,CCL3,CCL3L3,CD4,CXCL8,EIF6,FOS,FYN,IDO1,IFIT2,IL6,JUN,MAP2K3	 	
P1	 	infliximab	 	biologic drug	 	0.000	bias	-0.433	1.622	2.59E-02	BMP2,CCL18,CCND2,CXCL8,DDIT4,EDN1,G0S2,IL17D,MSC,MT1X,NFKBIA,PTGS2,SLC7A5,TNFRSF4	 	
P1	 	ACVR1C	-0.797	kinase	Inhibited	-2.400	 	0.206	-2.896	2.59E-02	BCL2L1,CCNG2,CDKN2B,FOS,JUNB,SMAD7	 	
P1	 	AXIN1	0.752	other	 	-0.391	bias	-0.313	0.303	2.59E-02	APCDD1,CCND2,CSRNP1,FOS,GSK3B,HRAS	 	
P1	 	BARX2	0.094	transcription regulator	 	0.314	bias	0.418	-0.605	2.59E-02	ESR1,FLNA,HSPA9,MMP9,MYL3,TIMP1	 	
P1	 	CREB3L1	0.053	transcription regulator	 	1.746	bias	0.390	0.810	2.59E-02	COL1A1,COL1A2,HSPA5,SLC1A4,SPP1,TFF3	 	
P1	 	ITGA6	-0.356	transmembrane receptor	 	0.701	bias	0.390	-0.227	2.59E-02	BCL2L1,CCND2,DVL2,ENPP2,ITGA3,ITGA7	 	
P1	 	Pkg	 	group	 	-0.816	bias	0.376	-1.738	2.59E-02	EDN1,EGR1,FOS,FOSB,JUN,TXN	 	
P1	 	RNF20	0.115	enzyme	 	1.633	 	-0.088	1.850	2.59E-02	FOS,HOXA9,MYC,NR4A2,PA2G4,RHOB	 	
P1	 	S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF	 	chemical reagent	 	-0.922	bias	0.383	-1.839	2.59E-02	CCL2,CD86,CXCL8,IL6,MMP9,PTGS2	 	
P1	 	W7	 	chemical reagent	 	1.387	bias	-0.383	2.238	2.59E-02	BIRC3,CCL2,CD14,CD86,CXCL8,FOS	 	
P1	 	cuprizone	 	chemical toxicant	 	-1.516	bias	0.279	-2.189	2.59E-02	CCL3L3,CSPG4,FOS,MBP,S1PR1,SOCS3	 	
P1	 	hydrochloric acid	 	chemical - endogenous non-mammalian	 	-1.000	 	0.201	-1.401	2.59E-02	CCL2,CXCL2,CXCL8,FOS,IL6,JUN	 	
P1	 	lisinopril	 	biologic drug	 	1.664	bias	-0.334	2.478	2.59E-02	CAST,FOS,JUN,KDR,LDLR,MMP2	 	
P1	 	retinol	 	chemical drug	 	0.896	bias	0.334	0.083	2.59E-02	CXCL8,IL6,JUN,PLIN2,RARA,TF	 	
P1	 	glucosamine	 	chemical - endogenous mammalian	 	0.704	 	-0.114	1.087	2.64E-02	ACACA,ACADM,AGT,APOB,ASS1,ATP2A2,CCL2,DDIT3,LEP,LEPR,NDUFB9,PCCB	 	
P1	 	ONECUT1	0.068	transcription regulator	 	 	 	 	 	2.66E-02	ABCA8,AKR1C4,ALDH3A1,ALDH5A1,ATG101,ATG9A,BNIP3L,C2,CCT8,CDCA5,CEBPD,COL5A3,COPS7A,COX7A2L,CYGB,CYP51A1,DHRS4,EGR2,EMG1,EXOSC5,FADS3,G3BP2,GSS,GUF1,HLA-G,HSPA1A/HSPA1B,IRF3,MAP2K5,MYOF,NDUFAF4,NFKBIA,NUDT2,PACS1,PEX6,PFKFB1,PFKL,PI4KB,RPLP1,SEMA6A,SLC1A3,SLC25A13,THAP10,TNFSF10,TRMT12,TRPC4AP,TXNDC12,VWA5A,WBSCR22,WDR12	 	
P1	 	cephaloridine	 	chemical drug	 	1.119	bias	0.303	-0.256	2.67E-02	AKR1B10,ANGPTL4,CTGF,CXCL14,CYP1B1,DDIT4,DSG2,G6PD,GPNMB,GSTM5,HMOX1,HSPA1A/HSPA1B,MAPK8IP3,MESP1,NQO1,NUP93,PIR,POLA2,TFRC,TNFRSF12A,TRIB3	 	
P1	 	BMS-690514	 	chemical drug	 	-0.333	 	-0.228	0.350	2.67E-02	CCND3,CDKN1C,CTSH,DDIT3,DNAJB6,HSPA4,HSPA8,HSPE1,MCL1	 	
P1	 	MTTP	0.066	transporter	 	-1.127	 	-0.116	-0.810	2.67E-02	APOB,ATF6,CCL3L3,CD36,CIDEC,ERN1,GOT1,HSPA5,JUN	 	
P1	 	RAB1B	0.350	other	 	0.847	bias	0.289	0.005	2.67E-02	CXCL8,GOLGA3,JUN,KDELR3,RAB26,RAB32,RRAGC,STXBP1,YIF1A	 	
P1	 	S-adenosylmethionine	 	chemical - endogenous mammalian	 	-0.475	bias	-0.319	0.460	2.67E-02	ACACA,ACTG2,COL1A1,COL1A2,FOS,GCLM,HMOX1,MAF,MAFG	 	
P1	 	CTR9	0.122	other	 	0.547	 	0.091	0.310	2.74E-02	CXCL12,EGR3,EPAS1,HOXA9,IGFBP4,MYC,TRIM29	 	
P1	 	MST1	0.719	growth factor	 	1.085	 	-0.182	1.555	2.74E-02	BCL2L1,CTGF,FOS,GPC3,IL6,PTGS2,SPP1	 	
P1	 	N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester	 	chemical - protease inhibitor	 	1.912	bias	-0.351	2.835	2.74E-02	BCL2L1,HEY1,HEY2,IL6,NOTCH1,PTGDS,PTPRF	 	
P1	 	XIAP	0.082	enzyme	 	-1.461	 	0.185	-1.865	2.74E-02	CDH2,CDK4,COMMD1,CXCL8,IL6,PTGS2,SELE	 	
P1	 	ZBTB7A	-0.085	transcription regulator	 	 	 	 	 	2.74E-02	FOS,H19,MIA,MYC,PKM,SELE,SLC2A3	 	
P1	 	miR-30a-3p (and other miRNAs w/seed UUUCAGU)	 	mature microrna	 	1.890	bias	-0.501	 	2.74E-02	CYR61,HELZ,LIMA1,RSU1,SLC7A6,THBS1,TMEM2	 	
P1	 	TRADD	0.109	other	 	-1.480	bias	0.430	-2.681	2.74E-02	CCL2,CXCL2,CXCL8,IL6,MMP9,NFKBIA,TNFAIP3,VCAM1	 	
P1	 	indican	 	chemical - endogenous mammalian	 	-0.147	 	0.042	-0.264	2.74E-02	AGT,CCL2,CXCR4,HMOX1,NOX4,PTGS2,SELE,THBS1	 	
P1	 	sterol	 	chemical - endogenous mammalian	Inhibited	-2.144	bias	-0.251	-1.450	2.74E-02	ABCG1,ACACA,ACLY,DHCR7,GPAM,IDH1,LDLR,LPIN1	 	
P1	 	(+)-MK-801	 	chemical drug	 	1.875	 	0.088	1.537	2.79E-02	ALDOA,EGR1,FGF2,FOS,FOSB,GDI1,GJA4,HSPA5,ITGAM,JUN,JUNB,NFKBIA,NPTXR,PTPRF,STXBP1,TIMP1	 	
P1	 	CYP1B1	-0.938	enzyme	 	-0.180	 	0.027	-0.278	2.82E-02	CACHD1,CYP1B1,GSTM2,GSTM3,HMOX1,MARCO,MCAM,NQO1,RGS16,SOCS2,ST3GAL4,TNFSF10,TRPM8	 	
P1	 	Ccl2	 	cytokine	 	-0.260	 	0.215	-0.993	2.82E-02	ADIPOQ,CCL3L3,CD14,CTSB,CTSK,CXCL2,ETS1,IL6,KDR,KLF4,LEP,SDC4,VCAM1	 	
P1	 	TCF12	0.053	transcription regulator	 	 	 	 	 	2.82E-02	ARSA,CD4,CDKN2B,FAM86C1,GJB2,HADHA,HSD17B14,IL10RA,LRBA,MVD,NOTCH1,NR4A3,POMC	 	
P1	 	RAC2	0.430	enzyme	 	 	 	 	 	2.84E-02	ALDOA,BCL2L1,CCL3L3,CDH2,EFNB2,EGR2,FOS,MIF,PKM,PMP22,TSC22D1	 	
P1	 	SOX3	0.038	transcription regulator	 	1.000	bias	-0.475	2.899	2.86E-02	ANGPT1,APCDD1,AXIN1,BMPER,COBLL1,DUSP1,DUSP5,FARP1,FRZB,GBP4,IRX3,NRP1,RET,SOX17,SOX9,TNFRSF19,TXNRD1	 	
P1	 	KMT2A	0.145	transcription regulator	 	0.718	bias	0.488	-1.197	2.90E-02	ADRA1A,ADRA1B,CDKN2C,DUSP10,EGR1,EPHB3,ETS1,FOXC1,HOXA9,IGFBP4,KLF6,MECOM,MKX,MYC,SATB2,TET1,TRIB1,ZFAND2A	 	
P1	 	cholecalciferol	 	chemical - endogenous mammalian	 	0.290	 	0.176	-0.413	2.90E-02	BCL2L1,CCL18,CCL2,CD14,CD209,CD86,CEBPD,COL1A1,CTSK,EDN1,IGFBP3,ITGAM,NDUFAF4,PTPRB,RARA,SLC20A1,SPP1,TGFBR2	 	
P1	 	garcinol	 	chemical - endogenous non-mammalian	 	1.308	 	-0.213	2.210	2.93E-02	ADIPOQ,BCL2L1,CASP4,CDC34,DVL2,GSPT1,GTF3A,GULP1,MAF,MAP3K20,MNDA,NFE2L1,NR4A3,PERP,PLAT,TAF6,TNFRSF10B,VAV3,ZFP36	 	
P1	 	phorbol esters	 	chemical - other	 	-0.761	bias	0.365	-2.316	2.93E-02	CDH2,CXCL8,DUSP1,EGR1,ERCC1,FOS,IL6,ITGAM,JUN,JUNB,MMP9,ODC1,PLAT,PTGDS,PTGS2,SLC12A2,TIMP1,TNFSF10,TXN	 	
P1	 	TNFRSF8	-0.208	transmembrane receptor	 	-1.362	 	0.041	-1.513	2.96E-02	AHNAK,CCL3,CES2,CXCL8,CXCR4,GBP1,JUNB,MRTO4,MYC,ODC1,PBX3,PCDH7,TMEM41B,TNFSF10	 	
P1	 	minocycline	 	chemical drug	 	-0.862	bias	-0.396	0.596	2.96E-02	ATF3,BCL2L1,CD163,CD86,CDK4,CXCL8,FOS,IL6,ITGAM,MBP,NANOS1,NGF,PTGS2,VCAM1	 	
P1	 	vitamin E	 	chemical drug	 	0.360	bias	-0.325	1.471	2.96E-02	ACTA1,BCL2L1,CAT,CAV1,CCL2,CD36,EGR1,MMP2,PLAT,POMC,PRMT1,SPP1,UCP2,VCAM1	 	
P1	 	RARA	0.604	ligand-dependent nuclear receptor	 	0.802	 	0.007	0.759	2.99E-02	ACACA,ADAM17,ADH1C,ALDH1A1,ALDH1A2,ARPC5L,ATF5,CCPG1,CLMN,CLOCK,COBL,CRABP2,DUSP1,EGR1,EGR2,EGR3,ENAH,FLCN,FOLR2,FOS,FOXC1,GAP43,HLA-G,IL6,JUN,LMO3,MAP1B,MGP,MYC,MYCN,NEDD9,NRP1,PGLS,PHF19,PTGS2,PTTG1,PVR,RARA,RET,RNF38,RUNX1,SMPD1,SP110,THBD,TNFRSF10B,XK,ZNF544	 	
P1	 	ATF1	-0.161	transcription regulator	 	-0.246	 	0.234	-0.765	3.03E-02	CYP51A1,EGR1,FTH1,HLA-G,HMOX1,JUN,PDE3B,PTGS2,TGFBR2,THBS1	 	
P1	 	GHR	-0.300	transmembrane receptor	 	1.294	 	0.000	1.294	3.03E-02	ADIPOQ,IGFBP3,IGFBP4,IL6,LEP,LHCGR,MYC,SOCS2,SOCS3,SPP1	 	
P1	 	HDAC6	0.070	transcription regulator	 	0.381	 	0.198	-0.202	3.03E-02	ADAMTS1,COL1A1,CYP1B1,HIF1A,IL6,JUN,JUNB,LTBP2,MYC,TAGLN	 	
P1	 	HDL	 	complex	 	-0.595	 	-0.090	-0.317	3.03E-02	ABCG1,ADIPOQ,CCL2,CD86,HIF1A,ITGAM,PTGIS,PTGS2,SIAH2,VCAM1	 	
P1	 	TSC22D3	0.209	transcription regulator	 	1.473	 	-0.219	2.157	3.03E-02	CCL2,CD86,COL1A1,CXCL8,DUSP1,EGR2,EGR3,IL6,PTGS2,SELE	 	
P1	 	FST	1.331	other	 	-1.303	 	0.072	-1.548	3.06E-02	ADIPOQ,ATP1A2,CD36,CIDEA,FST,HP,IL6,INHBB,MMP2,SAA1,SMAD7,THRSP	 	
P1	 	carboplatin	 	chemical drug	 	0.577	bias	0.293	-0.436	3.06E-02	ASNS,CAPN6,GPNMB,IER3,LXN,MYC,PNKD,SPP1,TIMP1,TNFRSF12A,TUBB,UPP1	 	
P1	 	Hsp90	 	group	 	0.615	bias	0.294	-0.470	3.07E-02	BCL2L1,CARM1,CCND2,CD4,CDK4,DLG4,ERBB2,ESR1,HSPA1A/HSPA1B,IL6,LYN,MYC,SRC,SYN1,ZFAND2A	 	
P1	 	PPP3CA	-0.461	phosphatase	 	 	 	 	 	3.07E-02	ATP2A2,CDK4,GRN,LAMP2,LITAF,LPAR1,MYH1,PMP22,PRDX5,PTGFR,PTGS2,RCAN1,SDC4,SPP1,TF	 	
P1	 	Cd2+	 	chemical toxicant	 	0.152	bias	0.401	-0.643	3.08E-02	DDIT3,FOS,HMOX1,MYC,PTGS2	 	
P1	 	Collagen type II	 	complex	 	1.710	 	-0.167	2.070	3.08E-02	BMP2,BMP4,BMP6,CCL3L3,IL6	 	
P1	 	D-tubocurarine	 	chemical drug	 	 	 	 	 	3.08E-02	EGR1,IL6,LITAF,PTPRA,TFPI2	 	
P1	 	GABBR1	0.134	g-protein coupled receptor	 	1.172	 	-0.143	1.489	3.08E-02	ATF4,BMP2,IL6,POMC,SPP1	 	
P1	 	Mn(III)-tetrakis-(4-benzoic acid) porphyrin	 	chemical reagent	 	-1.342	 	-0.143	-1.021	3.08E-02	AGT,DDIT3,HIF1A,MCL1,SELE	 	
P1	 	NHLH2	-0.009	other	 	0.000	bias	0.270	-0.540	3.08E-02	ADRB2,CD68,IL6,POMC,UCP2	 	
P1	 	Nos	 	group	 	-0.739	bias	0.347	-1.508	3.08E-02	CD59,EGR1,FOS,HMOX1,TIMP1	 	
P1	 	PI-103	 	chemical - kinase inhibitor	 	1.125	 	-0.167	1.492	3.08E-02	CIDEA,CIDEC,IL6,MCL1,TNFRSF10B	 	
P1	 	dihydroartemisinin	 	chemical drug	 	-0.900	bias	-0.319	-0.275	3.08E-02	CDK4,MMP2,MMP9,MYC,PTGS2	 	
P1	 	gossypol	 	chemical drug	 	0.684	 	-0.143	0.991	3.08E-02	ATF3,ATF4,BCL2L1,CXCL8,TNFRSF10B	 	
P1	 	lonafarnib	 	chemical drug	 	1.414	bias	-0.287	2.027	3.08E-02	BIRC3,DDIT3,MMP9,PTGS2,TNFRSF10B	 	
P1	 	manganese	 	chemical - endogenous mammalian	 	 	 	 	 	3.08E-02	C5AR1,DDIT3,GAPDH,HSPA5,PTGS2	 	
P1	 	mir-143	 	microrna	 	-1.387	 	-0.215	-0.910	3.08E-02	COL3A1,MAPK7,MMP2,PRKCE,TAGLN	 	
P1	 	pyruvic acid	 	chemical - endogenous mammalian	 	-0.391	bias	0.287	-1.025	3.08E-02	ALDOA,FOS,SLC2A3,TNFRSF10B,TNFSF10	 	
P1	 	selenite	 	chemical toxicant	 	0.000	bias	-0.251	0.496	3.08E-02	BCL2L1,MMP9,TIMP1,TXNRD2,UVRAG	 	
P1	 	spermidine	 	chemical - endogenous mammalian	 	-0.447	 	0.137	-0.753	3.08E-02	FOS,HMOX1,ITGAM,MMP2,ODC1	 	
P1	 	sulfasalazine	 	chemical drug	 	0.861	bias	-0.501	 	3.08E-02	CXCL8,HP,IER3,NFKBIA,TYMP	 	
P1	 	SERPINE1	0.289	other	 	1.287	bias	-0.287	2.031	3.21E-02	CXCL2,CXCL8,DLG4,FGF2,FOS,GAP43,IL6,PLAUR,TGFBR2	 	
P1	 	ZBED6	 	other	 	1.633	bias	-0.341	2.468	3.21E-02	BOP1,DDIT4,KCTD1,LAMP3,PMEPA1,PRPF19,SGK1,SPTBN1,UPP1	 	
P1	 	SPARC	-0.509	other	 	1.530	 	-0.084	1.915	3.23E-02	AKR1C3,ARG2,CEBPD,CIART,CIDEC,COL1A1,COL1A2,ELMOD3,IL6,LRP8,LYVE1,MMP2,NDRG1,NOTCH1,PAG1,PPIH,RABL6,SLC22A5,SOX9,SPARC,TRIM5,ZHX2	 	
P1	 	GHRL	0.015	growth factor	 	-0.605	 	0.056	-0.800	3.24E-02	ABCG1,ACACA,CYP11A1,DDIT3,EDN1,FOS,GPAM,IL6,LEP,NGF,POMC,PTGS2,SPP1	 	
P1	 	ZAP70	0.052	kinase	 	1.257	bias	0.501	 	3.24E-02	ANG,CD69,COL4A5,CSTF2,CYBA,DEXI,HS2ST1,KCNK3,PLEC,QPCT,SLC25A1,VPS4B,XAF1	 	
P1	 	SOD2	0.091	enzyme	 	-0.169	 	0.000	-0.169	3.26E-02	ACP5,ANGPT1,BCAS4,BCL2L1,CAT,COLEC12,DDIT3,GPR146,HMOX1,IL6,INHBE,MMP2,MMP9,MT1E,MYC,ODC1,PTGS2,SMPD1,TRPM8,ZNF358	 	
P1	 	PRKACA	0.149	kinase	 	0.404	bias	0.355	-0.755	3.32E-02	ADIPOQ,ANTXR1,CCND2,CCND3,HSPA1A/HSPA1B,LEP,MYC,NGF,SFRP4,SOCS3,VCAM1	 	
P1	 	RBM5	0.175	other	 	-0.113	 	-0.189	0.507	3.32E-02	BIRC3,BTG2,CD69,FAF1,GBE1,ITPA,MCL1,SERPINH1,TSPAN6,UBA1,UCP2	 	
P1	 	ELF3	0.109	transcription regulator	Inhibited	-2.604	bias	0.327	-3.456	3.35E-02	ANGPT1,ANGPTL4,ERBB2,IL6,KRT8,LYZ,PTGS2,TGFBR2	 	
P1	 	FGFR3	0.070	kinase	 	0.655	 	-0.125	0.901	3.35E-02	BCL2L1,BMP4,CCL3,FOS,FRMD3,MAF,SPARC,SPP1	 	
P1	 	MEF2A	-0.194	transcription regulator	 	-0.813	bias	0.454	-1.980	3.35E-02	ACTA1,ATP2A2,EDN1,FOS,JUN,KLF2,MEOX2,THBD	 	
P1	 	bafilomycin A1	 	chemical drug	Activated	2.804	 	0.190	2.270	3.35E-02	BCL2L1,DDIT3,IDO1,NFKBIA,PTGS2,SLC7A1,SQSTM1,TRIB3	 	
P1	 	sodium chloride	 	chemical - endogenous mammalian	 	0.301	bias	0.401	-1.152	3.37E-02	ADRA2A,AKR1B1,APLNR,CTGF,CXCL8,CYBA,DDIT4,EDN1,FOS,HIF1A,HMOX1,NOX4,PTGS2,SPP1	 	
P1	 	ursodeoxycholic acid	 	chemical - endogenous mammalian	 	0.715	 	0.134	0.258	3.37E-02	ABCC3,BCL2L1,COL1A1,COL1A2,CTGF,CYP27A1,DDIT3,GCLM,MAF,MAFG,PTGS2,SPARC,SPP1,TIMP1	 	
P1	 	7-ketocholesterol	 	chemical - endogenous mammalian	 	-0.218	 	0.079	-0.408	3.37E-02	CXCL8,DDIT3,EGR1,GNAI1,HSPA5,NOX4	 	
P1	 	CCKBR	0.078	g-protein coupled receptor	 	 	 	 	 	3.37E-02	ADIPOQ,CDH2,HIF1A,LEP,SPARC,TJP1	 	
P1	 	DAG1	0.299	transmembrane receptor	 	0.447	bias	0.358	-0.354	3.37E-02	CDH5,ITGA7,SGCB,SGCD,SGCG,SNTA1	 	
P1	 	ETV1	-0.068	transcription regulator	 	0.721	bias	0.390	-0.209	3.37E-02	ACSL3,ADRB2,ERBB2,POMC,SOX9,TGFBR2	 	
P1	 	ammonium chloride	 	chemical drug	 	1.633	 	0.238	1.051	3.37E-02	CTSB,EDN1,IL6,LDLR,RCAN1,SQSTM1	 	
P1	 	chlorogenic acid	 	chemical drug	 	0.816	bias	-0.287	1.518	3.37E-02	CCL2,HMOX1,IL6,NINJ1,PTGS2,VCAM1	 	
P1	 	isoprenaline	 	chemical drug	Inhibited	-2.236	 	0.167	-2.610	3.37E-02	CTGF,FOS,MMP9,NGF,NR4A2,NR4A3	 	
P1	 	ketamine	 	chemical drug	 	0.580	 	0.100	0.399	3.37E-02	CXCL8,FOS,HK1,HMOX1,NQO1,PTGS2	 	
P1	 	leuprolide	 	biologic drug	 	-0.730	 	0.056	-0.865	3.37E-02	EGR1,MMP2,MMP9,NR4A3,PEA15,TIMP1	 	
P1	 	miR-7a-5p (and other miRNAs w/seed GGAAGAC)	 	mature microrna	 	-0.886	bias	-0.501	 	3.37E-02	FOS,IRS2,KMT5A,MAPKAP1,MKNK2,SLC3A2	 	
P1	 	thioridazine	 	chemical drug	 	1.342	 	0.167	0.968	3.37E-02	CDK4,LSS,MCL1,SERPINA3,SLC2A3,TAGLN	 	
P1	 	vitamin K2	 	chemical drug	 	1.732	bias	0.449	0.644	3.37E-02	CD14,CD24,COL6A1,MATN2,MGP,SPP1	 	
P1	 	IL27	0.084	cytokine	 	0.149	 	0.238	-0.964	3.41E-02	CCL2,CCL3,CCND2,CCND3,CD14,CD163,CD86,CDK4,CEBPD,CXCL8,EGR1,EGR2,FOS,HLA-DOA,IL6,ITGAM,MAF,MYC,PTGS2,RARRES3,SOCS3,SPTBN1,TNFRSF4,TNFSF10,VCAM1	 	
P1	 	COMMD1	0.816	transporter	 	0.000	bias	-0.501	 	3.43E-02	ALDOA,BIRC3,DDIT4,PFKFB3,STC2,TF,TFRC	 	
P1	 	JAK inhibitor I	 	chemical - kinase inhibitor	 	1.134	bias	-0.334	2.018	3.43E-02	CCND2,CXCL2,LHCGR,MMP9,PTGS2,SGK1,TIMP1	 	
P1	 	PF4	0.038	cytokine	 	-1.391	 	0.240	-2.017	3.43E-02	CCL2,CCL3,CD86,CNN1,CXCL8,IL6,KLF4	 	
P1	 	geranylgeranyl pyrophosphate	 	chemical - endogenous mammalian	 	0.896	 	-0.091	1.118	3.43E-02	BMP2,CCL2,CD55,KLF2,MMP9,PTGS2,VCAM1	 	
P1	 	stearic acid	 	chemical - endogenous mammalian	 	-0.570	 	0.167	-1.008	3.43E-02	ATF3,CCL3L3,EDN1,IL6,NFKBIA,PLIN2,PTGS2	 	
P1	 	ACTN4	-0.061	transcription regulator	 	-1.982	bias	0.390	-2.756	3.51E-02	CCL2,CXCL8,FOS,MYCN	 	
P1	 	AEBP1	0.944	peptidase	 	0.152	 	-0.100	0.351	3.51E-02	ABCG1,APOE,CD36,COL1A2	 	
P1	 	ATP7A	-0.196	transporter	 	 	 	 	 	3.51E-02	CCL2,ELN,PLA2G4A,POMC	 	
P1	 	Atrial Natriuretic Peptide	 	group	 	1.000	 	-0.167	1.334	3.51E-02	ADIPOQ,CTGF,EDN1,LEP	 	
P1	 	BCAR1	0.358	enzyme	 	 	 	 	 	3.51E-02	CDKN2B,EGR1,ESR1,RALA	 	
P1	 	BQ-788	 	chemical drug	 	-1.000	 	0.100	-1.201	3.51E-02	AQP9,CXCL2,EDN1,MCAM	 	
P1	 	HOXB7	0.115	transcription regulator	 	0.985	bias	0.390	0.217	3.51E-02	ANGPT1,CXCL8,FGF2,MMP9	 	
P1	 	IAPP	0.009	other	 	0.000	bias	0.401	-0.794	3.51E-02	BACE2,FOS,MYC,POMC	 	
P1	 	Igkv1-117	 	other	 	 	 	 	 	3.51E-02	CCND2,JUN,JUNB,MYC	 	
P1	 	NFKBIE	0.329	transcription regulator	 	-0.577	bias	0.501	 	3.51E-02	CCL2,CXCL8,SELE,VCAM1	 	
P1	 	NQO2	0.528	enzyme	 	0.000	 	0.201	-0.401	3.51E-02	CXCL12,CXCR4,MMP9,PTGS2	 	
P1	 	PIAS2	0.291	transcription regulator	 	 	 	 	 	3.51E-02	CDKN2B,FOS,LDLR,SLC11A1	 	
P1	 	RANBP9	0.109	other	 	-1.982	 	-0.201	-1.585	3.51E-02	DLG4,FOS,GAP43,JUN	 	
P1	 	RLIM	0.063	enzyme	 	-0.577	bias	0.501	 	3.51E-02	CDH2,CDKN2B,CTGF,SMAD7	 	
P1	 	RV 538	 	chemical reagent	 	-1.980	 	-0.201	-1.583	3.51E-02	ATP13A2,BCL2L1,LAMP2,PRNP	 	
P1	 	S1PR3	-0.506	g-protein coupled receptor	 	-1.981	bias	0.501	 	3.51E-02	ETS1,FOS,JUN,PTGS2	 	
P1	 	SU1498	 	chemical - kinase inhibitor	 	0.762	bias	-0.501	 	3.51E-02	CD55,ETS1,SELE,VCAM1	 	
P1	 	TAPI-1	 	chemical - protease inhibitor	 	-0.762	bias	-0.501	 	3.51E-02	LEPR,MMP2,MMP9,VCAM1	 	
P1	 	calmidazolium	 	chemical drug	 	-0.218	 	-0.201	0.176	3.51E-02	EGR1,FOS,SOX9,VCAM1	 	
P1	 	formononetin	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.51E-02	ABCC1,BMP2,CD86,IL6	 	
P1	 	pCPT-cAMP	 	chemical - kinase inhibitor	 	-1.982	bias	0.401	-2.778	3.51E-02	EGR1,FOS,JUN,JUNB	 	
P1	 	fenretinide	 	chemical drug	 	1.854	 	0.048	1.667	3.53E-02	AP2M1,DDIT3,ENAH,ERCC1,FYN,HIF1A,IL6,JUN,LEP,MGMT,MMP9,MYC,NCF2,NFKBIA,PTGS2,TNFRSF10B	 	
P1	 	vitamin D	 	chemical drug	 	0.426	 	0.064	0.235	3.53E-02	ADAMTS1,CCL2,CCL3L3,COMT,CYR61,IFI27,IL6,MGP,NFKBIA,S100A8,SGK1,SPP1	 	
P1	 	AGI-1067	 	chemical drug	 	 	 	 	 	3.55E-02	CCL2,IL6,VCAM1	 	
P1	 	Ap2 alpha	 	group	 	 	 	 	 	3.55E-02	ITGA10,PLAUR,PTGDS	 	
P1	 	BCL2A1	-0.022	other	 	 	 	 	 	3.55E-02	BCL2L1,CD69,CXCL8	 	
P1	 	CACNA1C	-0.056	ion channel	 	 	 	 	 	3.55E-02	CAV1,ENO1,PTGS2	 	
P1	 	CD99	0.386	other	 	 	 	 	 	3.55E-02	CAV1,FOSB,MMP9	 	
P1	 	CNGB3	0.007	ion channel	 	 	 	 	 	3.55E-02	CAPN2,DDIT3,HSPA5	 	
P1	 	DAB2	1.021	other	 	 	 	 	 	3.55E-02	AXIN1,DAB2,FOS	 	
P1	 	EFEMP2	0.666	other	 	 	 	 	 	3.55E-02	CTGF,ELN,MMP9	 	
P1	 	EFNB1	0.156	other	 	 	 	 	 	3.55E-02	BCL2L1,EPHB3,TEK	 	
P1	 	EIF3E	-0.040	other	 	 	 	 	 	3.55E-02	ANGPT1,EPAS1,FGF2	 	
P1	 	HIST1H1C	-1.076	other	 	 	 	 	 	3.55E-02	AXIN2,GAPDH,MYC	 	
P1	 	HSPB2	-0.073	other	 	 	 	 	 	3.55E-02	CCL2,CXCL8,HRAS	 	
P1	 	Irs3	 	other	 	 	 	 	 	3.55E-02	EGR1,IRS2,LEP	 	
P1	 	LDL-cholesterol	 	complex	 	 	 	 	 	3.55E-02	CXCR4,SHC1,THBD	 	
P1	 	MB	-0.089	transporter	 	 	 	 	 	3.55E-02	EPAS1,HIF1A,VCAM1	 	
P1	 	OPRK1	0.117	g-protein coupled receptor	 	 	 	 	 	3.55E-02	FOS,KDR,NRP1	 	
P1	 	PLA2G6	0.089	enzyme	 	 	 	 	 	3.55E-02	ATF4,BCL2L1,DDIT3	 	
P1	 	PLCE1	-0.910	enzyme	 	 	 	 	 	3.55E-02	HRAS,IL6,PTGS2	 	
P1	 	PPP1R14B	0.819	phosphatase	 	 	 	 	 	3.55E-02	EPAS1,HIF1A,KDR	 	
P1	 	RAB7B	0.244	peptidase	 	 	 	 	 	3.55E-02	CTSD,IGF2R,IL6	 	
P1	 	RNF111	0.328	enzyme	 	 	 	 	 	3.55E-02	CDKN2B,PMEPA1,SMAD7	 	
P1	 	RO4929097	 	chemical drug	 	 	 	 	 	3.55E-02	HEY1,HEYL,KDR	 	
P1	 	SDC4	0.622	other	 	 	 	 	 	3.55E-02	KLF2,KLF4,SOX9	 	
P1	 	SERPINA4	0.050	other	 	 	 	 	 	3.55E-02	CCL2,MYC,VCAM1	 	
P1	 	SH2B3	0.234	other	 	 	 	 	 	3.55E-02	HMOX1,SELE,VCAM1	 	
P1	 	SSPN	0.196	other	 	 	 	 	 	3.55E-02	CDH2,CTSB,PTGS2	 	
P1	 	SULT1E1	-0.079	enzyme	 	 	 	 	 	3.55E-02	IGFBP4,PTGS2,SULF2	 	
P1	 	TNFRSF10A	-0.171	transmembrane receptor	 	 	 	 	 	3.55E-02	CD14,IL6,ITGAM	 	
P1	 	WAC	0.062	other	 	 	 	 	 	3.55E-02	ALPL,G6PD,PDK4	 	
P1	 	Z-VEID-FMK	 	chemical reagent	 	 	 	 	 	3.55E-02	CCND2,CCND3,CDK4	 	
P1	 	ZMYND10	0.083	other	 	 	 	 	 	3.55E-02	MMP2,MMP9,THBS1	 	
P1	 	acetazolamide	 	chemical drug	 	 	 	 	 	3.55E-02	DDIT3,GUSB,HSPA5	 	
P1	 	blinatumomab	 	biologic drug	 	 	 	 	 	3.55E-02	CCL2,CXCL8,IL6	 	
P1	 	canrenoate potassium	 	chemical drug	 	 	 	 	 	3.55E-02	EDN1,PTGS2,SPP1	 	
P1	 	carboxymethylflavin	 	chemical - endogenous mammalian	 	 	 	 	 	3.55E-02	MMP2,MMP9,TIMP1	 	
P1	 	fluphenazine	 	chemical drug	 	 	 	 	 	3.55E-02	FOS,NR4A2,NR4A3	 	
P1	 	formylmethylflavin	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.55E-02	MMP2,MMP9,TIMP1	 	
P1	 	ingenol mebutate	 	chemical drug	 	 	 	 	 	3.55E-02	BCL2L1,PRKCD,PRKCE	 	
P1	 	jasplakinolide	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.55E-02	CTGF,SOX9,TAGLN	 	
P1	 	lumichrome	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.55E-02	MMP2,MMP9,TIMP1	 	
P1	 	miR-139-5p (miRNAs w/seed CUACAGU)	 	mature microrna	 	 	 	 	 	3.55E-02	KIT,RUNX1,SHC1	 	
P1	 	miR-491-5p (and other miRNAs w/seed GUGGGGA)	 	mature microrna	 	 	 	 	 	3.55E-02	BCL2L1,MMP2,MMP9	 	
P1	 	obatoclax	 	chemical drug	 	 	 	 	 	3.55E-02	ATF3,ATF4,MCL1	 	
P1	 	poly(U)RNA	 	chemical reagent	 	 	 	 	 	3.55E-02	CCL2,CXCL8,IL6	 	
P1	 	propyl gallate	 	chemical toxicant	 	 	 	 	 	3.55E-02	CXCL8,PLA2G2A,PTGS2	 	
P1	 	pyridoxamine	 	chemical - endogenous mammalian	 	 	 	 	 	3.55E-02	CXCL8,DDIT3,IL6	 	
P1	 	retinol acetate	 	chemical drug	 	 	 	 	 	3.55E-02	ALPL,RARA,TF	 	
P1	 	zofenopril	 	chemical drug	 	 	 	 	 	3.55E-02	HMOX1,IL6,TIMP1	 	
P1	 	TRAF2	0.458	enzyme	 	-0.900	 	0.000	-0.900	3.57E-02	ADM,BIRC3,CARMIL1,CCL2,CCR1,CXCL8,GPR34,IL6,KLF2,MMP9,NDRG1,PBX3,PPFIBP2,PRNP,RSU1,SELE,TNFAIP3	 	
P1	 	lysophosphatidylcholine	 	chemical - other	Inhibited	-2.397	bias	0.349	-3.422	3.57E-02	CAT,CCL2,CCL3L3,CXCL8,EGR1,HBEGF,IL6,JUN,MBP,PLAUR	 	
P1	 	CNR1	-0.265	g-protein coupled receptor	 	0.225	 	0.223	-0.874	3.58E-02	ACACA,ADIPOQ,ADORA1,ALPL,APCDD1,APOE,BMP2,BMP4,ERBB2,FGF2,FOS,HAGH,HEY2,HEYL,HSPA4,IL6,LEP,MDK,POMC,PTGS2,RAD21,SLC22A17,SLC35B2,SLIT2,TIMP1,TJP1,VEGFC	 	
P1	 	HIST1H1T	0.013	other	 	0.471	bias	0.303	-0.815	3.59E-02	CD36,COPS7B,DLG4,FARP1,FKBP4,FOS,GLUL,HSPA4,MAN2B1,MARS,METTL22,MRPL38,PARVA,PCCB,PHLDA1,PLA2G5,RILPL1,TEX2	 	
P1	 	Hist1h1a	 	other	 	0.471	bias	0.303	-0.815	3.59E-02	CD36,COPS7B,DLG4,FARP1,FKBP4,FOS,GLUL,HSPA4,MAN2B1,MARS,METTL22,MRPL38,PARVA,PCCB,PHLDA1,PLA2G5,RILPL1,TEX2	 	
P1	 	HSF1	-0.109	transcription regulator	 	-0.870	 	0.043	-1.091	3.63E-02	AHSA1,ATG7,ATN1,BCL2L1,CCT3,CCT5,CCT8,COBL,COL18A1,FKBP4,HMOX1,HSPA1A/HSPA1B,HSPA4,HSPA8,HSPE1,IL6,JUN,LDLR,LMAN2L,MBOAT7,MCL1,PDZD2,POLA2,PTOV1,RAD51D,RANGAP1,RARRES3,SERPINH1,SHC1,SPHK2,STIP1,VCAM1,XAF1	 	
P1	 	RHO	0.061	g-protein coupled receptor	 	-1.976	 	0.072	-2.233	3.69E-02	ACADM,AP2A2,C1QA,CEBPD,COL1A2,CRABP1,CSF1R,FOS,HIST1H1C,PCOLCE,PRPH,SGK1,TNFAIP3	 	
P1	 	GTF2B	-0.273	transcription regulator	 	 	 	 	 	3.82E-02	ASNS,CCND2,ETS2,GAPDH,IRF3,LHCGR,NFKBIA,RBBP8,TNFAIP3	 	
P1	 	ITGAV	0.164	transmembrane receptor	 	1.740	 	0.236	1.049	3.82E-02	BCL2L1,CD36,COL1A1,COL1A2,FOS,LDLR,MMP2,MMP9,TIMP1	 	
P1	 	NLRP12	-0.180	other	 	1.865	 	-0.215	2.493	3.82E-02	CXCL12,CXCL2,CXCL8,CXCR4,HLA-F,HLA-G,IL6,JUN,LY96	 	
P1	 	SOX2	0.064	transcription regulator	Activated	2.496	 	-0.038	2.759	3.86E-02	ABCC3,ALDH1A1,ANGPT1,APCDD1,ATF3,AXIN1,AXIN2,BCL2L1,BMP4,BMPER,CNFN,COBLL1,COL1A1,CRABP2,CSF1R,CTGF,CXCL14,CXCR4,DKK3,DUSP1,DUSP5,EMX2,ETS2,ETV5,EVPL,FARP1,FOS,FRZB,FST,GADD45B,GBP4,GSK3B,H19,HEY1,IER5L,IRX3,JUN,KDR,KLF4,KLF6,MYCN,NOTCH1,NR5A2,NRP1,PRKCD,SOX17,TET1,TF,TNFRSF19,TULP3,TXNRD1,VEGFC,ZFP42	 	
P1	 	DOCK8	-0.463	other	 	-0.775	bias	0.501	 	3.89E-02	CCND2,DAB2,EDN1,HDC,IFIT2,IL6,ISG20,LMO4,NFKBIZ,PELI1,PLAT,PTGS2,RGS1,RILPL1,TSC22D1	 	
P1	 	GNA12	0.281	enzyme	Inhibited	-2.720	bias	0.313	-3.755	3.95E-02	CNN1,CXCL8,FOS,G6PD,GCLM,GSR,MMP2,MYC,MYH11,PSMB5,PTGS2,RRAS2,SOS1,TAGLN,TXNRD1,VAV3	 	
P1	 	IFI16	-0.235	transcription regulator	 	0.636	bias	0.446	-1.137	3.95E-02	CCL2,CCL3,CSF3R,CXCL8,EDN1,ESR1,FAF1,GADD45A,IL6,LDLR,MIF,MTHFD2,NFKBIA,SELE,SFTPD,VCAM1	 	
P1	 	SMAD2	-0.048	transcription regulator	 	-0.956	bias	0.310	-2.195	3.97E-02	CCNG2,CDH2,CDH5,CDKN2B,CTGF,GADD45B,HMOX1,IL6,MMP2,MMP9,NET1,S1PR1,SELE,SMAD7,THBS1,TPM1,VEGFC	 	
P1	 	LGALS3	0.084	other	 	-0.572	 	0.107	-0.936	3.98E-02	ADIPOQ,CCL3L3,CCR1,COL3A1,COL5A2,CTSH,DDOST,ENPP2,FSCN1,IL6,ITGA10,ITGAM,MYC,PRKCSH,SAA1,SELE,SOCS3,VCAM1	 	
P1	 	KMT2D	-0.086	transcription regulator	 	0.967	bias	0.501	 	3.99E-02	ACADM,ACOT4,ADGRG1,ADGRG2,BTG3,CA4,CD55,CHURC1,CKAP4,CRIP1,CSPG4,CTSD,FHL1,GALK1,GPRC5C,GPX7,GUSB,HDDC2,IGSF1,NIPSNAP3A,NPR3,NUDT14,PCDH7,PTTG1,RAB38,REEP6,SFXN4,SLC35G2,SMAD6,SMO,SORD,WDSUB1	 	
P1	 	HSPA5	2.484	enzyme	 	0.802	 	-0.072	1.002	4.05E-02	ACLY,BCL2L1,DDIT3,ERN1,ESR1,HSPA5,HSPA8,IL6	 	
P1	 	VTN	0.058	other	 	0.758	 	0.196	0.251	4.05E-02	COL1A1,COL1A2,EFNB2,ITGAM,MMP2,MMP9,PLAUR,PTGS2	 	
P1	 	WWTR1	-0.042	transcription regulator	 	1.414	 	0.130	1.047	4.05E-02	BMP2,COL1A1,CTGF,CXCL2,CXCL8,IL6,SMAD7,SPP1	 	
P1	 	exenatide	 	biologic drug	 	-1.964	 	0.050	-2.062	4.05E-02	CTGF,FOS,HMOX1,IL6,IRS2,ITGAM,MMP9,PTGS2	 	
P1	 	1'-acetoxychavicol acetate	 	chemical reagent	 	0.447	bias	-0.501	 	4.12E-02	BCL2L1,BIRC3,MMP9,MYC,PTGS2	 	
P1	 	24-hydroxycholesterol	 	chemical - endogenous mammalian	 	1.371	 	0.100	1.151	4.12E-02	ABCG1,AGT,APOE,HSPA5,LDLR	 	
P1	 	FABP1	0.035	transporter	 	-0.447	 	-0.167	-0.073	4.12E-02	CD36,FAAH,GOT1,HMOX1,SLC27A1	 	
P1	 	FNDC5	0.781	other	Activated	2.200	bias	0.435	1.244	4.12E-02	ALPL,ATF4,COL1A1,FNDC5,SPP1	 	
P1	 	HOXB4	-0.019	transcription regulator	 	-0.447	bias	0.501	 	4.12E-02	CCND2,CCND3,GPX3,JUNB,MYC	 	
P1	 	LRPAP1	0.363	other	 	-0.130	 	0.100	-0.352	4.12E-02	DDIT3,LDLR,MMP2,SERPINA3,SORL1	 	
P1	 	MIR101	 	group	Activated	2.200	bias	-0.270	2.795	4.12E-02	CDH5,CLDN5,DUSP1,MCL1,PTGS2	 	
P1	 	PDGFRA	-0.126	kinase	 	 	 	 	 	4.12E-02	COL1A1,DAB2,FOS,KIT,MYC	 	
P1	 	PPARα-RXRα	 	complex	 	0.447	bias	0.501	 	4.12E-02	AP2A2,GOT2,IL6,NFKBIA,SLC27A1	 	
P1	 	STK3	0.223	kinase	 	1.342	 	-0.033	1.416	4.12E-02	CTGF,GPC3,IL6,SFTPD,SPP1	 	
P1	 	TCF7L1	-0.042	transcription regulator	 	1.342	 	-0.143	1.662	4.12E-02	ATF3,CCND2,JUN,KLF4,PYCR2	 	
P1	 	TNFSF9	-0.247	cytokine	 	0.314	bias	0.301	-0.348	4.12E-02	BCL2L1,CD14,CXCL8,IL6,VCAM1	 	
P1	 	alpha-tocopherol succinate	 	chemical drug	 	-1.467	bias	-0.270	-0.878	4.12E-02	EGR1,FGF2,HIF1A,UCP2,VCAM1	 	
P1	 	amphotericin B	 	chemical drug	 	 	 	 	 	4.12E-02	CCL2,CXCL8,IL6,SPP1,TIMP1	 	
P1	 	caffeic acid	 	chemical drug	 	 	 	 	 	4.12E-02	AKR1B1,CAT,CCL2,CXCL8,PTGS2	 	
P1	 	fluoride	 	chemical - endogenous mammalian	 	1.964	bias	0.501	 	4.12E-02	DDIT3,FOS,GADD45A,HSPA5,VCAM1	 	
P1	 	lauric acid	 	chemical - endogenous mammalian	 	-1.197	bias	0.501	 	4.12E-02	CCL3L3,CD86,CXCL8,IL6,PTGS2	 	
P1	 	MUC1	0.216	other	 	-0.918	 	0.230	-1.538	4.17E-02	ABCC1,ALDH1A1,BCL2L1,CAT,CD86,CXCL8,HIF1A,IL6,MT1G,NFKBIA	 	
P1	 	mir-145	 	microrna	 	-1.390	bias	-0.301	-0.463	4.17E-02	ADAM17,CDH2,COL5A1,FSCN1,IL6,MYC,MYH11,PDE3B,SOX9,TAGLN	 	
P1	 	SOX9	1.214	transcription regulator	 	1.016	bias	0.285	0.083	4.20E-02	CDH2,COL1A1,COMP,CTGF,CXCR4,CYP26B1,FOS,H19,KIT,LBP,MIA,PTGDS,SOX9	 	
P1	 	CCL3	-0.596	cytokine	 	-1.741	bias	0.418	-2.750	4.22E-02	CCL2,CCL3,CCR1,FOS,IL6,ITGAM,SELE	 	
P1	 	CTSB	0.500	peptidase	 	-0.436	bias	0.319	-1.272	4.22E-02	CDK4,COL1A1,CTSB,CXCL2,KDR,MYC,PLAUR	 	
P1	 	NR2C2	0.203	ligand-dependent nuclear receptor	 	0.926	 	0.185	0.486	4.22E-02	APOE,CD36,HADHA,LHCGR,POMC,SLC27A1,THRSP	 	
P1	 	SUPT16H	0.280	transcription regulator	 	 	 	 	 	4.22E-02	ACTA1,DUSP5,EGR1,HIST1H1C,HNRNPK,HSPA1A/HSPA1B,KRT8	 	
P1	 	UCN-01	 	chemical drug	 	-0.071	bias	-0.293	0.625	4.22E-02	BCL2L1,CCND3,CDK4,CXCL8,ERCC1,MCL1,RHOB	 	
P1	 	ochratoxin A	 	chemical toxicant	 	-0.352	 	0.000	-0.352	4.22E-02	BCL2L1,CDH2,COL3A1,GSTM5,MMP9,NQO1,TIMP1	 	
P1	 	BAG1	0.110	other	 	 	 	 	 	4.28E-02	BCL2L1,FOS,GADD45A,JUN,NEDD4L,PTGS2	 	
P1	 	DOT1L	0.051	phosphatase	 	 	 	 	 	4.28E-02	EDN1,HOXA9,RPLP0,RPS2,SPI1,TUBA1C	 	
P1	 	DUSP5	-0.808	phosphatase	 	1.633	bias	-0.451	2.738	4.28E-02	ALDH1A3,CH25H,EGR1,EGR3,SRXN1,ZFP36	 	
P1	 	HOXD3	-0.305	transcription regulator	 	0.000	 	0.223	-0.546	4.28E-02	COL1A1,IGFBP3,MMP2,TAGLN,TGM2,THBS1	 	
P1	 	PPP1R15A	-0.507	other	 	0.447	 	0.039	0.356	4.28E-02	ATF4,DDIT3,DLG4,GADD45A,HSPA5,IL6	 	
P1	 	PYCARD	0.376	transcription regulator	 	-1.131	bias	0.324	-1.774	4.28E-02	CXCL8,DUSP10,IL6,MMP9,NOTCH1,PTGS2	 	
P1	 	apicidin	 	chemical - endogenous non-mammalian	 	0.000	 	0.050	-0.123	4.28E-02	CCR1,H6PD,PRKCD,ROR1,SDPR,TGM2	 	
P1	 	calyculin A	 	chemical toxicant	 	-0.816	 	-0.026	-0.752	4.28E-02	CCL2,CCND2,CYP1B1,EGR1,MCL1,ODC1	 	
P1	 	carbenoxolone	 	chemical toxicant	 	-0.816	 	-0.079	-0.623	4.28E-02	ACACA,CTGF,CYBA,NOX4,PTGS2,SPP1	 	
P1	 	finasteride	 	chemical drug	 	-1.633	bias	0.290	-2.344	4.28E-02	EDN1,FOS,HIF1A,IL6,KDR,SRD5A1	 	
P1	 	peoniflorin	 	chemical drug	 	0.640	 	0.100	0.400	4.28E-02	ENO1,HMOX1,PPP1R1B,PSMB7,RUNX1,TUBB	 	
P1	 	rosuvastatin	 	chemical drug	 	1.455	 	-0.100	1.698	4.28E-02	CYBA,HMOX1,IL6,KIT,LDLR,NAB1	 	
P1	 	RB1	-0.090	transcription regulator	Activated	3.730	 	0.124	2.999	4.29E-02	ACO2,ALPL,ATP6V1D,ATP6V1F,BTG3,CASP4,CBX5,CDCA5,COA3,COX17,CPA4,CTGF,DDX11,EDNRA,EGR1,FAM86B1,FGF2,FOS,FST,GADD45GIP1,GHITM,GPS2,H1F0,HACD3,HRAS,ICT1,ID1,IL6,KDR,KIT,LACTB,LIG1,MAF,MAP2K3,MCM2,MECR,MRPL12,MRPL17,MRPL55,MT1G,MTOR,MYC,MYL6B,MYOM2,NDUFA10,NDUFA13,NDUFA9,NDUFB10,NDUFS7,NDUFV1,NME1,PBX3,PGD,PMEPA1,POMC,PTX3,SOX7,SRPRA,TMEM97,TPO,TUBG1,UQCRC1	 	
P1	 	Collagen type I	 	complex	 	0.560	bias	0.297	-0.492	4.30E-02	APOE,CDH2,COL1A1,EIF4EBP1,F13A1,HDGF,ITGA1,ITGA3,KDR,MCL1,MMP2,MMP9,MYC,PTGS2	 	
P1	 	R5020	 	chemical reagent	 	-1.182	bias	0.312	-2.097	4.30E-02	BCL2L1,BIRC3,CTSD,DUSP5,ERBB2,HBEGF,HSD11B2,IER3,INHBB,IRS2,MT2A,MYC,SAA1,SGK1	 	
P1	 	erlotinib	 	chemical drug	 	1.792	 	0.134	1.319	4.30E-02	BCL2L1,CCL2,CD14,COL8A1,CXCL8,EGR1,ENAH,FCER2,IL6,MME,NFKBIA,NOX4,SLC2A3,TNFRSF10B	 	
P1	 	RIPK2	-0.029	kinase	 	-1.121	bias	0.312	-2.296	4.36E-02	ACACA,ACADM,CD36,CD69,CD86,CXCL2,DGAT2,IL6,LDLR,LMO4,SCAP,SELE,SLC27A1,SLC2A6,VCAM1	 	
P1	 	C/ebp	 	group	 	0.640	bias	0.401	-0.336	4.43E-02	ADH1C,ALDH3A1,CSF1R,F8,HIF1A,ID1,IL6,LEP,ORM1,PTGS2,SFTPD	 	
P1	 	CD86	0.688	transmembrane receptor	 	-1.801	 	0.119	-2.189	4.43E-02	BCL2L1,CCL3,CD69,CD86,EGR2,FCER2,HOMER2,IDO1,IL6,NFKBIA,TNFAIP3	 	
P1	 	MMP2	0.532	peptidase	 	0.928	 	0.188	0.370	4.51E-02	BCL2L1,BMP2,CLDN5,COL18A1,CXCL12,ITGA3,MYC,PPP2R1A,TJP1	 	
P1	 	cilostazol	 	chemical drug	 	0.396	 	-0.157	0.862	4.51E-02	ABCG1,CCL2,CLDN5,HMOX1,KDR,MMP9,NR4A2,SELE,VCAM1	 	
P1	 	pimagedine	 	chemical drug	 	-0.198	 	-0.129	0.185	4.51E-02	BCL2L1,CAST,CTGF,CXCL8,GADD45B,HBEGF,HMOX1,IL6,TNFSF10	 	
P1	 	black raspberry extract	 	chemical drug	 	 	 	 	 	4.61E-02	AHNAK,AKR1B10,ALDH3A2,AOX1,C21orf33/LOC102724023,DUSP5,FST,H2AFZ,HMOX1,INHBB,LAMP2,LEPR,LRBA,MAP2K3,MCL1,MYO10,PECR,PLS3,RGS17,TMED2,TTC1,TXNL1	 	
P1	 	BCL6	-0.302	transcription regulator	 	1.040	 	-0.140	1.601	4.62E-02	ALCAM,BCL2L1,CCL2,CCL3,CCND2,CD69,CLEC10A,COL1A1,DNAJB11,EPB41L2,FCER2,FCGRT,FGF2,FTH1,GADD45A,IL6,ITGA3,JUNB,LITAF,MAF,MGP,MYC,PLA2G2A,SOCS3,SOX9,TNFRSF14	 	
P1	 	capsaicin	 	chemical drug	 	1.178	 	-0.046	1.327	4.62E-02	ABCC3,ATF4,CAT,CXCL8,DDIT3,FOS,GDF15,HMOX1,LEP,MMP2,MMP9,PTGS2	 	
P1	 	fingolimod	 	chemical drug	 	0.762	 	-0.240	1.504	4.62E-02	ADIPOQ,BCL2L1,CCND3,CD36,CD69,CDK4,COL3A1,CTGF,IL6,LIPE,S1PR1,S1PR3	 	
P1	 	mir-29	-0.097	microrna	 	-0.067	bias	-0.371	1.192	4.74E-02	AOX1,CARD9,CCL8,CD276,COL1A1,ELN,IDO1,ITGA11,KIT,MCL1,MMP2,PMP22,THBS1	 	
P1	 	JUND	0.048	transcription regulator	 	0.600	 	0.234	-0.055	4.82E-02	AGT,COL6A1,CSTA,FTH1,HMOX1,IL6,LHCGR,MMP9,NCF2,NOX4,PLAUR,SFTPD,SPP1,TIMP1	 	
P1	 	doxycycline	 	chemical drug	 	-1.854	 	-0.019	-1.797	4.82E-02	BCL2L1,BMP2,CD86,COL3A1,CXCL12,EGR2,FGF2,HSPA1A/HSPA1B,JCHAIN,MMP2,MMP9,NGF,PTGS2,TIMP1	 	
P1	 	4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone	 	chemical toxicant	 	-1.270	bias	0.363	-2.209	4.84E-02	FOS,HP,JUN,JUNB,LOX,PTGS2,SPP1,TF	 	
P1	 	4-tert-octylphenol	 	chemical toxicant	 	-0.674	bias	0.401	-1.702	4.84E-02	ADIPOQ,CD55,CLSTN2,EMP1,ESR1,MYC,RPN2,SRC	 	
P1	 	ABCB4	0.080	transporter	 	-0.711	bias	-0.468	0.598	4.84E-02	COL1A1,COL1A2,CTGF,MMP2,NR5A2,SPARC,SPP1,TIMP1	 	
P1	 	ETV4	0.036	transcription regulator	 	0.305	bias	0.301	-0.337	4.84E-02	CAV1,CXCL8,ERBB2,MMP9,PLEC,PTGS2,SPP1,TGFBR2	 	
P1	 	NFE2L1	1.088	transcription regulator	 	1.408	bias	0.365	0.521	4.84E-02	GCLM,HMOX1,LEP,NQO1,PSMB2,PSMB5,PSMB6,PSMB7	 	
P1	 	SERPINA1	-0.119	other	 	-0.759	 	0.093	-0.960	4.84E-02	ANGPTL4,ATF6,CCL2,DDIT3,FCER2,HSPA5,LDLR,RGS16	 	
P1	 	TNC	-0.220	other	Inhibited	-2.180	 	0.167	-2.646	4.84E-02	CCL2,EDNRA,FOS,IL6,MBP,MMP2,MYC,TPM1	 	
P1	 	sodium orthovanadate	 	chemical reagent	 	0.014	 	0.178	-0.474	4.84E-02	BCL2L1,COL1A1,CXCL8,HIF1A,IFIT2,NFKBIA,PLAUR,SLC2A5	 	
P1	 	HOXC6	0.378	transcription regulator	 	0.000	 	0.186	-0.527	4.84E-02	CARD8,FAM49A,IGFBP3,MME,RUNX1,SH3D19,SLC1A3,TNFAIP8,VCAM1,ZBTB7C	 	
P1	 	mir-181	-0.139	microrna	Activated	2.621	bias	-0.387	3.635	4.84E-02	CD163,CD69,KLF6,MCL1,PBX3,PRKCD,RGS5,SLC47A1,SMAD7,TGM2	 	
P1	 	AGER	0.219	transmembrane receptor	 	-1.347	 	0.201	-2.072	4.87E-02	CCL2,CCL3,CCL3L3,CTSK,CXCL8,EGR1,IL6,MMP2,MMP9,PTGS2,S100A8,S100A9,SELE,TJP1,VCAM1	 	
P1	 	RBL1	0.163	transcription regulator	 	0.629	bias	-0.368	1.652	4.87E-02	CASP4,DUSP10,FGF2,FOS,LHCGR,MCM2,MT1G,MTOR,MYC,MYCN,NOTCH1,PA2G4,POMC,SFRP1,THBS1	 	
P1	 	TRAF3	0.397	enzyme	 	1.035	 	-0.103	1.452	4.87E-02	ADM,BIRC3,CARMIL1,CCR1,CXCL12,CXCL2,FCER2,GPR34,HSPA5,IL6,NDRG1,NFKBIA,PBX3,PPFIBP2,RSU1,TMEM8B,TNFAIP3	 	
P1	 	2,4,5,2',4',5'-hexachlorobiphenyl	 	chemical toxicant	 	-1.175	 	0.198	-1.939	4.88E-02	ABCC3,ACSL3,ADRB2,AKAP12,AOX1,CLDN5,EBF1,ELOVL6,EXOC4,GADD45A,GADD45B,MYC,NOL3,PIK3R2,SLC1A4,SMAD7	 	
P1	 	HMGB1	0.329	transcription regulator	 	-0.120	bias	0.398	-1.614	4.88E-02	CCL2,CCL3,CD86,CXCL8,GLUL,HIF1A,HLA-DRB1,HLA-G,IL6,MIA,MMP9,PLA2G2A,PTGS2,SELE,SMAD7,VCAM1	 	
P1	 	2-[[9-isopropyl-6-[[4-(2-pyridyl)phenyl]methylamino]purin-2-yl]amino]butan-1-ol	 	chemical reagent	 	-0.152	bias	-0.501	 	4.94E-02	CCL3L3,CD86,CDK4,IL6	 	
P1	 	3,5-diiodothyronine	 	chemical - endogenous mammalian	Activated	2.000	bias	0.410	1.179	4.94E-02	AK1,CD36,ENO1,GAPDH	 	
P1	 	4-hydroxyestradiol-17beta	 	chemical - endogenous mammalian	 	1.030	bias	0.401	0.241	4.94E-02	CAT,HSPA5,NQO1,SFRP2	 	
P1	 	ACVR1B	0.397	kinase	 	 	 	 	 	4.94E-02	CCNG2,FST,HP,SMAD7	 	
P1	 	CLCN5	0.020	ion channel	 	-0.159	 	-0.100	0.036	4.94E-02	CA3,CTSB,CUBN,TXN	 	
P1	 	CSK	1.063	kinase	 	1.969	 	0.046	1.879	4.94E-02	FOS,FYN,IL6,SRC	 	
P1	 	Cebp	 	complex	 	 	 	 	 	4.94E-02	CSF3R,CXCL8,IL6,MIA	 	
P1	 	Ciap	 	group	 	-1.000	 	-0.137	-0.726	4.94E-02	BCL2L1,CXCL2,IL6,MYC	 	
P1	 	DRD1	0.053	g-protein coupled receptor	 	 	 	 	 	4.94E-02	EGR1,FOS,FOSB,JUNB	 	
P1	 	LY6E	0.788	other	 	0.849	bias	-0.501	 	4.94E-02	CD14,CXCL8,IL6,NFKBIA	 	
P1	 	MZF1	0.277	transcription regulator	 	 	 	 	 	4.94E-02	AXL,CDH2,FGF2,MS4A2	 	
P1	 	PARP2	0.575	enzyme	 	-1.980	 	0.228	-2.431	4.94E-02	ADIPOQ,CD36,LEP,TNFRSF10B	 	
P1	 	PLA2G2D	-0.106	enzyme	 	0.000	bias	-0.501	 	4.94E-02	CD68,IL6,ITGAM,S100A9	 	
P1	 	PPBP	-0.084	cytokine	 	1.987	bias	0.410	1.172	4.94E-02	COL15A1,COL18A1,COL6A3,GLG1	 	
P1	 	TAS1R3	0.029	g-protein coupled receptor	 	0.000	 	-0.228	0.456	4.94E-02	DDIT4,SLC1A5,SLC3A2,TSC2	 	
P1	 	UCP2	1.023	transporter	 	0.000	bias	-0.410	0.821	4.94E-02	ADIPOQ,EPAS1,IL6,PKM	 	
P1	 	azathioprine	 	chemical drug	 	0.254	bias	-0.501	 	4.94E-02	ACLY,CD1C,G3BP2,TNFSF10	 	
P1	 	biotin	 	chemical - endogenous mammalian	 	 	 	 	 	4.94E-02	CYP1B1,HLCS,PC,PMP22	 	
P1	 	clonidine	 	chemical drug	 	1.067	bias	-0.319	1.700	4.94E-02	EGR1,FOS,MYC,POMC	 	
P1	 	coal tar	 	chemical drug	 	0.000	bias	0.410	-0.821	4.94E-02	CYP1B1,HMOX1,NQO1,PTGS2	 	
P1	 	enoxacin	 	chemical drug	 	-1.000	bias	-0.410	-0.179	4.94E-02	ATP6V1B2,ATP6V1E1,CTSK,FOS	 	
P1	 	enterolactone	 	chemical - endogenous non-mammalian	 	-0.152	bias	0.410	-0.966	4.94E-02	ESR1,KDR,SPARC,SPP1	 	
P1	 	hesperetin	 	chemical drug	 	 	 	 	 	4.94E-02	BCL2L1,DHCR24,LDLR,NOTCH1	 	
P1	 	mir-373	0.049	microrna	 	1.990	bias	-0.319	2.625	4.94E-02	ANGPTL4,CXCL8,IL6,TGFBR2	 	
P1	 	mir-7	0.085	microrna	 	-0.569	bias	-0.501	 	4.94E-02	ABCC1,KLF4,MAPKAP1,MKNK2	 	
P1	 	nitroglycerin	 	chemical drug	 	0.283	 	0.137	0.012	4.94E-02	CXCL8,HMOX1,IL6,PLAUR	 	
P1	 	tyrphostin AG 1296	 	chemical - kinase inhibitor	 	0.849	bias	-0.319	1.480	4.94E-02	CD14,ITGAM,JUN,PTGS2	 	
P1	 	(+)-fluprostenol	 	chemical drug	 	 	 	 	 	4.95E-02	FGF2,NR4A2	 	
P1	 	(E)-1-(2-nitrovinyl)naphthalene	 	chemical reagent	 	 	 	 	 	4.95E-02	MYC,SQSTM1	 	
P1	 	(E)-9-(2-nitrovinyl)anthracene	 	chemical reagent	 	 	 	 	 	4.95E-02	MYC,SQSTM1	 	
P1	 	3,4-methylenedioxyamphetamine	 	chemical drug	 	 	 	 	 	4.95E-02	BCL2L1,JUN	 	
P1	 	5R,11R-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol	 	chemical reagent	 	 	 	 	 	4.95E-02	ESR1,TGFBR3	 	
P1	 	ACS84	 	chemical reagent	 	 	 	 	 	4.95E-02	GCLM,HMOX1	 	
P1	 	AHNAK	0.834	other	 	 	 	 	 	4.95E-02	CCND2,MYC	 	
P1	 	ALPL	1.163	phosphatase	 	 	 	 	 	4.95E-02	ALPL,SPP1	 	
P1	 	ATF7	-0.022	transcription regulator	 	 	 	 	 	4.95E-02	DDIT3,SELE	 	
P1	 	ATP1A2	-0.783	transporter	 	 	 	 	 	4.95E-02	ATP1A2,FOS	 	
P1	 	Akr1b7	 	enzyme	 	 	 	 	 	4.95E-02	ADIPOQ,LEP	 	
P1	 	BAG4	0.051	other	 	 	 	 	 	4.95E-02	APOB,IL6	 	
P1	 	BCAT2	0.747	enzyme	 	 	 	 	 	4.95E-02	ADIPOQ,LEP	 	
P1	 	BMP1	0.279	peptidase	 	 	 	 	 	4.95E-02	IGFBP3,OGN	 	
P1	 	BUB1B	0.090	kinase	 	 	 	 	 	4.95E-02	CDC20,PTTG1	 	
P1	 	CCDC3	-1.980	other	 	 	 	 	 	4.95E-02	ACACA,DGAT2	 	
P1	 	CCKAR	0.050	g-protein coupled receptor	 	 	 	 	 	4.95E-02	EGR1,LEP	 	
P1	 	CD151	-0.305	other	 	 	 	 	 	4.95E-02	CD69,MMP9	 	
P1	 	CD300LF	-0.071	other	 	 	 	 	 	4.95E-02	CXCL8,MMP9	 	
P1	 	CHCHD4	0.544	enzyme	 	 	 	 	 	4.95E-02	HIF1A,NDUFS7	 	
P1	 	CIAO1	0.378	transcription regulator	 	 	 	 	 	4.95E-02	FAM96B,NARFL	 	
P1	 	CMYA5	0.425	other	 	 	 	 	 	4.95E-02	ATP2A2,MYH1	 	
P1	 	CRIP2	0.052	other	 	 	 	 	 	4.95E-02	CXCL8,IL6	 	
P1	 	CTH	0.055	enzyme	 	 	 	 	 	4.95E-02	DDIT3,HSPA5	 	
P1	 	CYSLTR2	-0.040	g-protein coupled receptor	 	 	 	 	 	4.95E-02	CXCL8,EGR1	 	
P1	 	DEFA1 (includes others)	0.106	other	 	 	 	 	 	4.95E-02	CD4,CXCL8	 	
P1	 	DGKH	-0.082	kinase	 	 	 	 	 	4.95E-02	CCL2,CXCL8	 	
P1	 	DNAJC3	0.035	other	 	 	 	 	 	4.95E-02	ATF4,DDIT3	 	
P1	 	DOK2	0.503	other	 	 	 	 	 	4.95E-02	DOK2,MYC	 	
P1	 	DROSHA	0.067	enzyme	 	 	 	 	 	4.95E-02	MYC,THBS1	 	
P1	 	EAF2	-0.161	transcription regulator	 	 	 	 	 	4.95E-02	HIF1A,VHL	 	
P1	 	EDEM1	0.886	enzyme	 	 	 	 	 	4.95E-02	DDIT3,HSPA5	 	
P1	 	EEF2K	0.030	kinase	 	 	 	 	 	4.95E-02	BCL2L1,MAP1B	 	
P1	 	EIF2B1	0.039	translation regulator	 	 	 	 	 	4.95E-02	ATF4,DDIT3	 	
P1	 	ELL	-0.133	transcription regulator	 	 	 	 	 	4.95E-02	FOS,MYC	 	
P1	 	Eif2	 	complex	 	 	 	 	 	4.95E-02	HSPA5,PTGS2	 	
P1	 	Esr1-Estrogen-Sp1	 	complex	 	 	 	 	 	4.95E-02	CTSD,FOS	 	
P1	 	FH535	 	chemical reagent	 	 	 	 	 	4.95E-02	ESR1,MMP9	 	
P1	 	FTL	0.051	enzyme	 	 	 	 	 	4.95E-02	FTH1,TFRC	 	
P1	 	FTMT	0.143	enzyme	 	 	 	 	 	4.95E-02	FTH1,TFRC	 	
P1	 	Fetal Hemoglobin	 	complex	 	 	 	 	 	4.95E-02	HIF1A,HMOX1	 	
P1	 	GRB10	0.494	other	 	 	 	 	 	4.95E-02	FOS,KDR	 	
P1	 	HIST1H1A	-0.041	other	 	 	 	 	 	4.95E-02	FOS,GLB1	 	
P1	 	HOXB8	0.155	transcription regulator	 	 	 	 	 	4.95E-02	MYLK,TAGLN	 	
P1	 	HSPB3	0.171	other	 	 	 	 	 	4.95E-02	CCL2,CXCL8	 	
P1	 	HSPBP1	0.161	other	 	 	 	 	 	4.95E-02	HSPA1A/HSPA1B,HSPA2	 	
P1	 	INHBC	0.168	growth factor	 	 	 	 	 	4.95E-02	INHBE,JUNB	 	
P1	 	Il3r	 	complex	 	 	 	 	 	4.95E-02	CXCL8,SELE	 	
P1	 	Irs4	 	other	 	 	 	 	 	4.95E-02	EGR1,IRS2	 	
P1	 	LPXN	0.196	transcription regulator	 	 	 	 	 	4.95E-02	MYH11,TAGLN	 	
P1	 	LSS	0.828	enzyme	 	 	 	 	 	4.95E-02	ABCG1,LDLR	 	
P1	 	MARK3	0.144	kinase	 	 	 	 	 	4.95E-02	ACP5,ADIPOQ	 	
P1	 	MMS19	0.478	transcription regulator	 	 	 	 	 	4.95E-02	FAM96B,NARFL	 	
P1	 	MSRA	0.972	enzyme	 	 	 	 	 	4.95E-02	HMOX1,MSRB2	 	
P1	 	MXD3	-0.026	transcription regulator	 	 	 	 	 	4.95E-02	MYCN,ODC1	 	
P1	 	MYH11	-1.803	other	 	 	 	 	 	4.95E-02	CNN1,MYH11	 	
P1	 	Mac	 	complex	 	 	 	 	 	4.95E-02	CD59,ZFP36	 	
P1	 	Mn2+	 	chemical - endogenous mammalian	 	 	 	 	 	4.95E-02	ATP13A2,GAP43	 	
P1	 	N-ethylmaleimide	 	chemical reagent	 	 	 	 	 	4.95E-02	LEPR,SELE	 	
P1	 	N4BP1	0.623	other	 	 	 	 	 	4.95E-02	JUN,JUNB	 	
P1	 	NDUFAF3	0.670	other	 	 	 	 	 	4.95E-02	CTSD,ESR1	 	
P1	 	NIK	 	group	 	 	 	 	 	4.95E-02	CXCL8,IL6	 	
P1	 	NPAS4	-0.038	transcription regulator	 	 	 	 	 	4.95E-02	DDIT3,SYN1	 	
P1	 	P2RY6	0.060	g-protein coupled receptor	 	 	 	 	 	4.95E-02	CXCL8,VCAM1	 	
P1	 	PHGDH	0.231	enzyme	 	 	 	 	 	4.95E-02	CHEK2,MMP2	 	
P1	 	PON3	0.443	enzyme	 	 	 	 	 	4.95E-02	IL6,LEP	 	
P1	 	PPP1R1A	-0.894	phosphatase	 	 	 	 	 	4.95E-02	ERN1,HSPA5	 	
P1	 	PQQ cofactor	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	HMOX1,NGF	 	
P1	 	PROS1	-0.073	other	 	 	 	 	 	4.95E-02	CXCL8,IL6	 	
P1	 	PRR7	0.084	other	 	 	 	 	 	4.95E-02	CD69,JUN	 	
P1	 	PSMC5	0.288	transcription regulator	 	 	 	 	 	4.95E-02	CCND2,LYN	 	
P1	 	PVALB	0.036	other	 	 	 	 	 	4.95E-02	C1QC,VEGFD	 	
P1	 	RAB7A	0.429	enzyme	 	 	 	 	 	4.95E-02	EGR1,FOS	 	
P1	 	RAPGEF4	-0.391	other	 	 	 	 	 	4.95E-02	CTSK,SPP1	 	
P1	 	RING1	0.355	transcription regulator	 	 	 	 	 	4.95E-02	FOS,JUN	 	
P1	 	RNA polymerase I	 	complex	 	 	 	 	 	4.95E-02	MARS,RNA28S5	 	
P1	 	RPP38	0.058	enzyme	 	 	 	 	 	4.95E-02	RPP21,RPP25	 	
P1	 	Rbpjl2	 	other	 	 	 	 	 	4.95E-02	HEY1,HEY2	 	
P1	 	Rp-8-Br-cGMPS	 	chemical - kinase inhibitor	 	 	 	 	 	4.95E-02	FOS,ITGAM	 	
P1	 	PRAG1	-0.650	kinase	 	 	 	 	 	4.95E-02	HEY1,HEY2	 	
P1	 	SPTBN1	-1.456	other	 	 	 	 	 	4.95E-02	BCL2L1,FOS	 	
P1	 	STRAP	0.201	other	 	 	 	 	 	4.95E-02	JUN,MYC	 	
P1	 	TAPI	 	chemical - protease inhibitor	 	 	 	 	 	4.95E-02	CXCL8,PRNP	 	
P1	 	TH17 Cytokine	 	group	 	 	 	 	 	4.95E-02	CXCL8,IL6	 	
P1	 	TMBIM1	-0.528	other	 	 	 	 	 	4.95E-02	MMP2,MMP9	 	
P1	 	TRAF7	0.414	enzyme	 	 	 	 	 	4.95E-02	JUN,MYC	 	
P1	 	TUBB1	-0.151	other	 	 	 	 	 	4.95E-02	TUBB,TUBB2A	 	
P1	 	USP6	0.035	peptidase	 	 	 	 	 	4.95E-02	BMP4,MMP9	 	
P1	 	Yap1	 	transcription regulator	 	 	 	 	 	4.95E-02	MYH11,TAGLN	 	
P1	 	acacetin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	FAF1,PTGS2	 	
P1	 	acriflavine	 	chemical toxicant	 	 	 	 	 	4.95E-02	ADIPOQ,SOCS3	 	
P1	 	actinomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	IGFBP4,SAA1	 	
P1	 	ampelopsin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	HMOX1,HSPA5	 	
P1	 	astemizole	 	chemical drug	 	 	 	 	 	4.95E-02	CCL2,IL6	 	
P1	 	benfotiamine	 	chemical drug	 	 	 	 	 	4.95E-02	AKR1B1,NOX4	 	
P1	 	cetylpyridinium	 	chemical drug	 	 	 	 	 	4.95E-02	CTSK,FOS	 	
P1	 	cibacron blue F 3GA	 	chemical reagent	 	 	 	 	 	4.95E-02	CXCL8,THBS1	 	
P1	 	danazol	 	chemical drug	 	 	 	 	 	4.95E-02	CXCL8,IL6	 	
P1	 	dietary fat derivative	 	chemical drug	 	 	 	 	 	4.95E-02	APOB,ITGAM	 	
P1	 	dobutamine	 	chemical drug	 	 	 	 	 	4.95E-02	HMOX1,LEP	 	
P1	 	ergosterol-5,8-peroxide	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	CTGF,VCAM1	 	
P1	 	etodolac	 	chemical drug	 	 	 	 	 	4.95E-02	CD36,THBS1	 	
P1	 	exemestane	 	chemical drug	 	 	 	 	 	4.95E-02	HMOX1,NQO1	 	
P1	 	ezatiostat	 	chemical drug	 	 	 	 	 	4.95E-02	ABCC1,GCLM	 	
P1	 	fluoroquinolone	 	chemical drug	 	 	 	 	 	4.95E-02	MMP2,MMP9	 	
P1	 	gelatinase	 	group	 	 	 	 	 	4.95E-02	CLDN5,TJP1	 	
P1	 	glycodeoxycholic acid	 	chemical - endogenous mammalian	 	 	 	 	 	4.95E-02	IL6,TNFRSF10B	 	
P1	 	hyodeoxycholic acid	 	chemical - endogenous mammalian	 	 	 	 	 	4.95E-02	ABCG1,APOE	 	
P1	 	imperatorin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	IL6,PTGS2	 	
P1	 	lanthanum chloride	 	chemical reagent	 	 	 	 	 	4.95E-02	AXL,MGP	 	
P1	 	latanoprost	 	chemical drug	 	 	 	 	 	4.95E-02	MMP2,MMP9	 	
P1	 	lopinavir	 	chemical drug	 	 	 	 	 	4.95E-02	CCL2,DDIT3	 	
P1	 	mercaptopropionylglycine	 	chemical drug	 	 	 	 	 	4.95E-02	EPAS1,HIF1A	 	
P1	 	methylamphotericin B	 	chemical drug	 	 	 	 	 	4.95E-02	SPP1,TIMP1	 	
P1	 	miR-330-5p (and other miRNAs w/seed CUCUGGG)	 	mature microrna	 	 	 	 	 	4.95E-02	ETS1,SMO	 	
P1	 	miR-331-3p (miRNAs w/seed CCCCUGG)	 	mature microrna	 	 	 	 	 	4.95E-02	CDCA5,ERBB2	 	
P1	 	minodronate	 	chemical drug	 	 	 	 	 	4.95E-02	CCL2,CXCR4	 	
P1	 	muscarine	 	chemical toxicant	 	 	 	 	 	4.95E-02	EGR1,SELE	 	
P1	 	myristoylated PKCzeta pseudosubstrate peptide inhibitor	 	chemical - kinase inhibitor	 	 	 	 	 	4.95E-02	LHCGR,VCAM1	 	
P1	 	natamycin	 	chemical drug	 	 	 	 	 	4.95E-02	SPP1,TIMP1	 	
P1	 	nickel subsulfide	 	chemical toxicant	 	 	 	 	 	4.95E-02	CXCL8,NDRG1	 	
P1	 	p-chloroamphetamine	 	chemical drug	 	 	 	 	 	4.95E-02	FOS,SMO	 	
P1	 	pentosan polysulfate	 	chemical drug	 	 	 	 	 	4.95E-02	MMP9,PRNP	 	
P1	 	phenol derivative	 	chemical toxicant	 	 	 	 	 	4.95E-02	HMOX1,USP47	 	
P1	 	phloretin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	ADIPOQ,HMOX1	 	
P1	 	pituitary adenylate cyclase-activating polypeptide	 	biologic drug	 	 	 	 	 	4.95E-02	CCND2,CCND3	 	
P1	 	polyethyleneimine	 	chemical reagent	 	 	 	 	 	4.95E-02	IDO1,IL6	 	
P1	 	potassium channel	 	group	 	 	 	 	 	4.95E-02	FOS,JUN	 	
P1	 	prochloraz	 	chemical reagent	 	 	 	 	 	4.95E-02	CYP1B1,ODC1	 	
P1	 	propentofylline	 	chemical drug	 	 	 	 	 	4.95E-02	GAP43,NGF	 	
P1	 	pycnogenols	 	chemical drug	 	 	 	 	 	4.95E-02	CXCL8,PTGS2	 	
P1	 	riociguat	 	chemical drug	 	 	 	 	 	4.95E-02	SPP1,TIMP1	 	
P1	 	ropivacaine	 	chemical drug	 	 	 	 	 	4.95E-02	ITGAM,MBP	 	
P1	 	sangivamycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.95E-02	IL6,JUN	 	
P1	 	silver nitrate	 	chemical drug	 	 	 	 	 	4.95E-02	HMOX1,SAA1	 	
P1	 	tenidap	 	chemical drug	 	 	 	 	 	4.95E-02	IL6,PTGS2	 	
P1	 	thioguanine	 	chemical drug	 	 	 	 	 	4.95E-02	MYC,TNFSF10	 	
P1	 	tyrphostin AG 18	 	chemical - kinase inhibitor	 	 	 	 	 	4.95E-02	AKR1C3,IL6	 	
P1	 	vapreotide	 	biologic drug	 	 	 	 	 	4.95E-02	CCL2,CXCL8	 	
P1	 	yohimbine	 	chemical drug	 	 	 	 	 	4.95E-02	EGR1,FOS	 	
P1	 	zeaxanthin	 	chemical drug	 	 	 	 	 	4.95E-02	MMP2,TIMP1	 	
P1	 	NPY1R	-0.437	g-protein coupled receptor	 	1.980	 	-0.193	2.362	5.35E-02	FOS,IL6,LEP,POMC,UCP2	 	
P1	 	NR1H3	-0.159	ligand-dependent nuclear receptor	Activated	2.693	 	0.131	2.183	5.91E-02	ABCG1,ACACA,ACSL3,ADRB2,APOE,ARG2,FBP1,GPAM,IL6,LDLR,MID1IP1,MMP9,NFKBIA,NR5A2,PLTP,PTGS2,RARA	 	
P1	 	arsenic	 	chemical toxicant	 	1.761	 	0.153	1.396	6.15E-02	BIRC3,ESR1,FOS,FTH1,HIF1A,KEAP1,NQO1	 	
P1	 	mannose	 	chemical - endogenous mammalian	Inhibited	-2.000	 	0.167	-2.334	6.64E-02	ATF4,FOS,HSPA5,THBS1	 	
P1	 	TSC1	0.202	other	 	-1.970	 	-0.052	-1.836	6.69E-02	DDIT3,EGR2,FAM129A,FLNA,HMOX1,IL6,IRS2,TSC2	 	
P1	 	NR1I2	-0.059	ligand-dependent nuclear receptor	Activated	2.221	 	0.130	1.590	7.10E-02	ABCC3,AHCY,ALDH1A1,ALDH3A2,ANG,CD36,CES1,CES2,CYP2C8,ELOVL6,GLUL,GOT1,GSTM1,GSTM3,GSTM5,GUSB,HMGCS1,IL6,JUN,MGP,PGD,POR,PTS,S100A8,TF,TGM2	 	
P1	 	ZBTB20	0.016	transcription regulator	 	1.857	 	0.029	1.761	7.38E-02	CYP2C8,GPC3,GSTM5,IL6,LEP,LEPR,NEDD9,NFKBIA,PDK4,SOCS2,SOCS3	 	
P1	 	folic acid	 	chemical - endogenous mammalian	Inhibited	-2.013	 	0.086	-2.279	8.21E-02	ABCC1,ANGPT1,BCL2L1,CERS6,IFI27,JUN,SFRP1,TEK,UNG,VCAM1	 	
P1	 	THRA	0.989	ligand-dependent nuclear receptor	Activated	2.359	 	-0.025	2.432	8.43E-02	ACACA,ANGPTL4,ATF4,ATP2A2,CCL2,CTSH,CXCL2,FOS,FRZB,FZD9,HMOX1,IL6,JUN,MBP,MYH1,NME1,POR,RCAN2,SLC9A1,THRSP	 	
P1	 	lipoxin A4	 	chemical - endogenous mammalian	Activated	2.534	 	-0.178	2.985	8.93E-02	CCL2,CXCL8,ESR1,HMOX1,IL6,PTGS2,SELE,TIMP1	 	
P1	 	SMARCA2	0.061	transcription regulator	Inhibited	-2.359	 	0.157	-2.823	9.23E-02	ACTA1,ALPL,CD36,COL11A1,HOXA9,ITGAM,KDR,MYLK,NME1,TAGLN,TUFT1	 	
P1	 	NR1H2	0.290	ligand-dependent nuclear receptor	Activated	2.496	 	0.119	2.091	9.78E-02	ABCG1,ACACA,AGT,APOE,ELOVL6,IL6,LDLR,LIPE,LRP8,MMP9,NFKBIA,PLTP,PTGS2,THRA	 	
P1	 	N-(3-oxododecanoyl)-homoserine lactone	 	chemical reagent	 	-1.954	 	0.000	-1.954	1.08E-01	CXCL2,CXCL8,IL6,PTGS2	 	
P1	 	ginsenoside Rb1	 	chemical - endogenous non-mammalian	Activated	2.000	 	0.072	1.857	1.08E-01	CXCL8,FOS,HBEGF,NGF	 	
P1	 	ETV5	1.479	transcription regulator	 	1.953	 	0.215	1.533	1.16E-01	ALCAM,CDH2,CXCL12,ETV5,MMP2,PKP2,SPP1,TJP1,TJP2	 	
P1	 	NANOG	-0.050	transcription regulator	 	-1.836	 	0.106	-2.245	1.20E-01	CCDC85A,CCND2,CDRT1,COL3A1,EGR1,FOS,FOSB,HNRNPH1,HSPA1A/HSPA1B,IER5L,KLF4,LYN,MAP1B,MYCN,NPIPA8 (includes others),PDCD4,RAPGEF5,TET1,TOB1,ZFP42	 	
P1	 	hexamethylene bisacetamide	 	chemical reagent	Inhibited	-2.626	 	-0.068	-2.448	1.30E-01	ALAS2,HSPA8,IMP4,NOL6,SNRPB,SNU13,SPI1,TFRC	 	
P1	 	KLF9	-0.669	transcription regulator	 	1.959	 	0.039	1.883	1.32E-01	ACP5,BMP2,COL1A1,ESR1	 	
P1	 	YWHAZ	0.042	enzyme	 	-1.964	 	0.000	-1.964	1.32E-01	ATF4,ATF6,HSPA5,MCL1	 	
P1	 	CD47	-0.222	transmembrane receptor	Activated	2.183	 	0.221	1.701	1.46E-01	COL1A1,CTSK,FCER2,IL6,KDR,MYC	 	
P1	 	uric acid	 	chemical - endogenous mammalian	Inhibited	-2.287	 	0.065	-2.524	1.58E-01	ADIPOQ,AGT,CCL2,CCL3,CCL3L3,CD86,CXCL2,CXCL8,HMOX1,IL6,KIF1A,LIG1,PARP2,PTGS2,PTTG1,TACC2	 	
P1	 	OMA1	0.228	peptidase	 	1.982	 	0.125	1.734	1.59E-01	ACADVL,DNM1L,LEP,NDUFA9	 	
P1	 	p70 S6k	 	group	Activated	2.000	 	0.167	1.666	1.65E-01	CCND3,CDH2,CDK4,GAP43,PDCD4	 	
P1	 	sodium selenite	 	chemical drug	 	1.982	 	0.079	1.826	1.65E-01	BCL2L1,MMP9,PTGS2,SEPHS2,WDR5	 	
P1	 	NPM1	-0.032	transcription regulator	Activated	2.236	 	0.056	2.111	1.66E-01	CCL2,CCL3,CXCL2,HOXA9,IL6,MMP9	 	
P1	 	Rxr	 	group	 	1.982	 	0.113	1.758	1.75E-01	ANGPTL4,APOE,CD36,CYP2C8,GADD45A,IL6,LEP,MGP,MYC,NR5A2,PLIN2,PLTP,POR,PTGS2,SPP1	 	
P1	 	COPS5	0.339	transcription regulator	 	1.982	 	0.088	1.807	1.87E-01	GPS1,HIF1A,LHCGR,MARS	 	
P1	 	Secretase gamma	 	complex	 	-1.851	 	0.196	-2.253	1.89E-01	CD86,HEY1,HEYL,PTPRF,RELN	 	
P1	 	desipramine	 	chemical drug	Activated	2.175	 	0.046	2.076	1.89E-01	ADRA2A,FGF2,FOS,HMOX1,IL6	 	
P1	 	NRF1	0.295	transcription regulator	Activated	2.138	 	0.239	1.466	1.90E-01	COX8A,CXCL8,FTH1,GCLM,HMOX1,NQO1,PPRC1,PVR,SURF1	 	
P1	 	lenalidomide	 	chemical drug	Inhibited	-2.132	 	-0.123	-1.557	1.97E-01	APTX,CCL3,DHTKD1,DTNA,FLNA,HIPK2,HLA-DRB1,HLA-DRB4,LIMA1,LRRC8B,MARCH2,NUP43,PCBP2,PPP4R3B,RGS1,RGS16,ROR1,SLC7A2,STAMBPL1,TET1,TNFRSF21,WDR4	 	
P1	 	naringenin	 	chemical - endogenous non-mammalian	Activated	2.449	 	-0.072	2.625	2.09E-01	CXCL8,HMOX1,HSPA5,LDLR,LYN,PTGS2	 	
P1	 	PD 169316	 	chemical - kinase inhibitor	 	1.964	 	-0.056	2.073	2.16E-01	BIRC3,CCND2,CCND3,PTGS2	 	
P1	 	morphine	 	chemical drug	 	-1.802	 	0.170	-2.550	2.60E-01	ADM,ADRBK1,CCL3L3,CXCL8,ERBB2,FOS,FOSB,IL6,ITGAM,JUNB,LEP,MBP,MMP9,NET1,NTRK3,PLAT,POMC,PTGS2,SPARC,THBS1,TXN	 	
P1	 	CDKN1A	0.134	kinase	 	1.899	 	-0.138	2.534	2.69E-01	BCL2L1,CCL2,CCND3,CDC20,CDK4,CDKN2B,CPA3,CTGF,CTSB,CTSK,CYR61,DUSP1,EDNRA,FANCG,GLB1,GRN,H2AFZ,HSPA1A/HSPA1B,HSPA5,IL6,ITGAM,LIMA1,MAF,MCM2,MMP9,MYC,NUSAP1,PARP2,POLD1,SAA1,SHC1,SOX9,ZNF84	 	
P1	 	PSEN2	0.364	peptidase	Inhibited	-3.212	 	-0.038	-3.072	2.93E-01	ATP2A2,C1QA,C1QB,COX8A,CYTIP,DBP,EMP1,ENPP2,GAPDH,KIF5B,NOTCH1,PTGS2,PTPRF,STAB1	 	
P1	 	PARK2	0.065	enzyme	Activated	2.207	 	-0.143	2.523	3.04E-01	AXIN2,KDR,MAOA,MCL1,MYC,NDUFS3	 	
P1	 	KDM2B	0.318	enzyme	 	1.982	 	-0.137	2.254	3.50E-01	CD24,CRABP2,SFRP2,SOX17,SOX7	 	
P1	 	TRH	0.077	other	Inhibited	-2.385	 	0.158	-2.760	3.54E-01	DUSP1,FOS,JUN,JUNB,POMC,PRKCE	 	
P1	 	MBP	1.595	other	Inhibited	-2.000	 	0.167	-2.334	3.75E-01	CCL2,IL6,LEPR,MYC	 	
P1	 	POU5F1	0.057	transcription regulator	Inhibited	-2.080	 	0.186	-3.119	3.90E-01	ANGPT1,APCDD1,AXIN1,BIRC3,BMPER,BNIP3L,CIDEA,CNFN,COBLL1,CRABP2,DUSP1,DUSP5,EVPL,FARP1,FRZB,GADD45A,GBP4,H19,ID3,IER5L,IRX3,KLF2,KLF4,MCL1,MYCN,NRP1,PMEPA1,RARA,SH3GLB1,SMAD7,SOX17,SPP1,SRC,STIM1,TET1,TF,TNFRSF10B,TNFRSF19,TNFRSF21,TNFSF10,TXNRD1,ZFP42	 	
P1	 	GDNF	0.067	growth factor	Inhibited	-2.135	 	0.218	-2.737	3.96E-01	CLDN5,CTSB,EGR1,EGR2,FOSB,HSD11B2,KIT,NNAT,PPP1R1B,STC1	 	
P1	 	CYP27B1	0.032	enzyme	 	1.960	 	-0.134	2.222	4.63E-01	ATP2B1,CCL3L3,CD14,IL6,SPP1	 	
P1	 	KCNK9	-0.068	ion channel	Activated	2.449	 	-0.110	2.719	4.81E-01	ACVR1C,DKK3,GADD45B,HP,KCNK3,NR4A2	 	
P1	 	MERTK	-0.079	kinase	Activated	2.186	 	0.014	2.157	5.69E-01	HDC,IL6,MARCO,RGCC,RILPL1	 	

Causal Networks for My Projects->David Bulger->P1

Diseases and Bio Functions for My Projects->David Bulger->P1
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	malignant solid tumor	1.13E-35	 	-1.386	 	-1.190	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,ATP6V1F,CBS/CBSL,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,MMP28,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ORM2,ANO3,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,ABHD1,CA12,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,LYVE1,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,SCRN1,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,CNN2,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,ATP6AP1,H2AFZ,KLF9,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,ACVR1C,AHNAK2,GJB2,CYP2R1,NPRL2,LIMCH1,PRPH,CD209,CD276,STAMBPL1,FCRLB,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,H2AFY2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,NMNAT2,CYP4X1,GOT1,WDR46,EGR3,MTURN,FBXO22,SLC4A7,PAWR,ATP10A,ALAD,NDUFAF2,C19orf48,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,ARHGEF35,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,RRM2B,ZNF239,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,PPOX,ZNF606,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,HCAR1,C9orf24,CEBPD,CDK4,HSD17B11,CTDSPL,SDHAF1,GADD45GIP1,PNPO,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,PTDSS2,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,PPFIBP2,SLC41A2,RNASE1,SLC35F6,DRG2,CD163,CEBPG,GPNMB,MYC,TGFBR2,GPX3,ADGRF5,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,RERG,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,NOL3,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,SPIRE2,ZSWIM3,AUP1,ME1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,CTAGE9 (includes others),RNLS,CANX,N4BP1,PNCK,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,DNAJA3,CSTF2,HEY2,GUCY1A3,GSTM3,FANCG,NAT10,STOML2,MMP2,TSSC1,IER3,SCNN1D,RAE1,RPP21,SERINC2,DOCK1,AQP9,PSMB2,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,PSMB10,CHCHD6,KAZN,KHDC1,VCAN,SERTAD4,CA3,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,FAM86C1,RBM6,ADCK2,PELI1,CHFR,DBNL,DNPH1,VPS52,CYP2C8,GPR137,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,LMO4,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,CHPF,FLRT2,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,KCNJ2,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CNPPD1,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,PROCR,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,ARL17A/ARL17B,STK39,UROS,MAPK8IP2,RIMS4,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,GPS1,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,UBE2I,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,C1orf216,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,CSRNP1,SERTAD1,APOLD1,ZNF428,ITM2C,COL11A1,GSTO2,CERCAM,FCGBP,HSD17B14,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EIF6,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,C19orf53,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,ANG,B9D1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,TMEM259,KANSL3,ASNS,THBS3,CORO2B,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,NDUFB9,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,YIF1B,PLA2G2A,TRMT12,GBP4,OTUB1,VPS9D1,LMO3,SLC48A1,RNF144A,RHBDD2,GALE,BMF,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,C1QBP,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,GNG2,TALDO1,PCDHA1,GPAA1,ZNHIT1,ANKRD33,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,SFRP2,PA2G4,KIAA1191,C1orf158,ATF5,TBCB,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,WSB2,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,IL20RB,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,UQCRC1,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IP6K3,EIF4EBP3,CTSH,MCOLN3,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,UBE2Q1,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,GALK1,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TNMD,TTC23,DDX28,TRIM29,FAM96B,POMGNT2,ALDH5A1,G3BP2,HEY1,CNFN,ZNF524,PRDM11,GPM6B,CBR3,GALM,GRN,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,C19orf12,TTYH3,ABCC3,C11orf68,RBP5,SGCD,PTER,CH25H,MT2A,ABCB6,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GSTM2,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,MED9,CAPG,PGAP3,PTGDS,C9orf114,OSBPL7,RBKS,KCNG1,CBX1,ORM1,TRIM39,HIF1AN,MRPS2,CUEDC2,KLHDC4,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,SF3B5,TPR,COPE,STX6,ABCF1,CRYL1,GTF3A,NAT14,KIFC2,CCL3,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,RBPMS,SUGP2,PWWP2B,NQO1,DLEU1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CXCL16,RCAN1,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,PLIN1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,PKIA,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,CCDC170,COLEC12,CDH2,ASGR1,CD68,PTPA,SLC22A17,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,BOD1,DHRS4,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,ACSM5,SLC2A6,CMTM8,STARD13,RHOU,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,HDC,DEFB1,WDR12,CYP1B1,YBX2,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,IGF2BP2,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,TAZ,FBN2,ADSSL1,ATP5D,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,EIF5,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,RARRES1,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,ALPL,CTDNEP1,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,TAF6,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,CCDC3,ZDHHC7,NDUFA13,TRIM69,WARS,CYTIP,TSPAN1,EDNRA,RCAN2,RTN3,ASS1,PAQR7,TLE1,PGGHG,EEF1G,SLC39A8,POR,IDUA,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,TRIAP1,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,FAM136A,CA4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,BCL2L1,KANK1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,NDUFS3,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,EMX2,GIMAP6,VPS25,F8,C16orf59,EPN1,RNF26,SNTB1,TCEA3,PLAUR,SAA2,FRMD4A,ORAOV1,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,EIF3C,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,RND2,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,MT1X,TIMM17B,COMMD9,FAHD2A,KAZALD1,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,PODXL2,TSPAN14,SAC3D1,TSPAN6,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,MAFG,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,C5orf15,ACP2,CD302,USP36,LAGE3,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,DKK3,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,RPS21,C16orf58,CCDC85A,THRSP,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,CSTA,SVEP1,SYTL2,MAP6,CA5B,CACNA1H,ASCC2,TSPAN13,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,SLCO2B1,TACO1,MYL3,ALDOC,NSUN4,TSHZ2,NUP43,ALDH1B1,PDIA5,RRP1,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,GPX7,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,CD86,GCC1,TFRC,P2RX6,SQSTM1,CHD1L,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,ZNF285,TECR,KLHDC9,IFI27,AHSA2,ASB1,RNF181,DUSP5,POFUT2,CCL2,IRF2BPL,RENBP,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,TSTA3,MED20,TJP1,GLRX2,RGS16,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,FBP1,TP53BP1,BMPER,PIN1,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,PDCD6,NBAS,PSMB5,ATF3,PKP2,RILPL1,BTG1,ZNF282,THRA,TRIM35,FOSB,GZMH,CDC42BPB,SDCBP,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,DPH5,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,CCDC107,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,ANKRD46,BSCL2,TNFRSF14,ATIC,SERPINE2,ATP6V1E1,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,FAM50B,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,ARRDC4,RPA1,SERINC1,GRAMD1A,RAD51D,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,DUS2,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PDDC1,ACSF2,FOLR2,NT5C,PFKL,SCO1,FAXDC2,TAX1BP3,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,C11orf24,LPP,SARS,COL18A1,NCKIPSD,PLAT,IL11RA,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,P4HTM,TRMT1,F11R,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,PLA2G15,XXYLT1,CLTB,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,D2HGDH,LPIN2,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,GLYAT,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,CCL18,MAP2K5,KATNB1,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,PCMT1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,MICALL1,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM222,TMEM132B,SPOCD1,FRMD1,FAM134B,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,RDH5,ZNF585A,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,GADD45B,HSDL1,ABCC9,CD69,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,LOX,SFTPD,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,KIF3B,POLR3B,PRUNE2,CMTM4,BCAS4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,TMEM37,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,C17orf49,FAM174B,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,WDR18,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,GTPBP3,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PARM1,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C1QTNF6,KBTBD11,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,C12orf76,CD55,KIAA0040,STK24,FMO1,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,LOC401052,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,CPZ,PDE8B,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,CAV1,ST6GALNAC2,KANK3,CEP170B,MGP,ATF4,DLG4,STK32A,EBF2,CDC16,CASQ2,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,FLOT1,TIMM8B,SMG5,THOP1,IFNAR2,BRF2,RHBDD1,TRAPPC3,ZNF579,CARD9,CTSA,IFT122,NRDE2,LRRN3,FBXW5,FSCN1,VARS2,PRELP,TRPC4AP,NCF2,MCEE,GAPDH,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,PHLDA2,GUCD1,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,LRRC20,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,SWI5,NOL12,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,FCER2,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,TRIB3,SLCO2A1,AGL,HSPA2,GLG1,PLA2G4A,SELM,NR4A2,NRXN2,SNUPN,FLNC,AIMP2,FAM129A,GPBAR1,MBD3,ATP1A2,XAF1,TMEM106C,TAF1C,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,UQCC3,SESN2,SLC38A10,AMDHD2,MBP,KLF6,ABCG1,C16orf91,HSPA4,MAP2K2,HDAC11,GCLM,CAST,CHTF18,CHMP1A,IER2,DOK2,GM2A,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,ELOVL6,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,NUDT2,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,C4orf3,C4BPB,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,WDR41,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,ZNF404,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,MFAP2,PEX16,DGCR6L,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,NANOS1,RRBP1,PCSK5,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,GLUL,ASPHD2,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,ELOF1,GBA,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,STK19,SEMA3G,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,MIOS,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,IPO13,SPRY2,NOP2,DENND1A,LSP1,BNIP3L,CPSF3,GABARAP,NEDD9,ACTR1A,RAB3IP,RAB43,EFR3A,RGS1,PHLDA1,TFG,RCN1,XPO5,CXCL12,LIPE,TAF10,SDC4,DCAF10,MTCH2,PLEKHG4,NARS,CEL,CYP26B1,PGD,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,KLF2,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,ERCC1,ITGAM,C9orf9,PKD1,SRPK3,SLC22A5,PLEKHH3,AK2,NFIX,RNF165,EPB41L3,PKM,PPP1CB,QPRT,TET1,GPR34,FBXO3,CDKN2B,ERV3-1,FAM110B,TNFRSF12A,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,NDUFAF3,COX17,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,FIZ1,KIAA0930,NEK11,EXOC4,LPAR1,DIP2C,JCHAIN,ELK1,DSG2	2624	
Cancer, Organismal Injury and Abnormalities	cancer	cancer	4.50E-35	 	-1.067	 	-1.012	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,ATP6V1F,CBS/CBSL,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,MMP28,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ORM2,ANO3,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,ABHD1,CA12,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,LYVE1,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,SCRN1,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,CNN2,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,ATP6AP1,H2AFZ,KLF9,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,ACVR1C,AHNAK2,GJB2,CYP2R1,NPRL2,LIMCH1,PRPH,CD209,CD276,STAMBPL1,FCRLB,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,NIPSNAP3A,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,H2AFY2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,NMNAT2,CYP4X1,GOT1,WDR46,EGR3,MTURN,FBXO22,SLC4A7,PAWR,ATP10A,ALAD,NDUFAF2,C19orf48,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,NELFE,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,ARHGEF35,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,RRM2B,ZNF239,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,PPOX,ZNF606,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,HCAR1,C9orf24,CEBPD,CDK4,HSD17B11,CTDSPL,SDHAF1,GADD45GIP1,PNPO,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,PTDSS2,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,PPFIBP2,SLC41A2,RNASE1,SLC35F6,DRG2,CD163,CEBPG,GPNMB,MYC,TGFBR2,GPX3,ADGRF5,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,RERG,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,NOL3,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,SPIRE2,ZSWIM3,AUP1,ME1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,CTAGE9 (includes others),RNLS,CANX,N4BP1,PNCK,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,ADGRL1,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,DNAJA3,CSTF2,HEY2,GUCY1A3,GSTM3,FANCG,NAT10,STOML2,MMP2,TSSC1,IER3,SCNN1D,RAE1,RPP21,SERINC2,DOCK1,AQP9,PSMB2,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,PSMB10,CHCHD6,KAZN,KHDC1,VCAN,SERTAD4,CA3,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,FAM86C1,RBM6,ADCK2,PELI1,CHFR,DBNL,DNPH1,VPS52,CYP2C8,GPR137,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,LMO4,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,CHPF,FLRT2,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,KCNJ2,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CNPPD1,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,MSMO1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,PROCR,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,ARL17A/ARL17B,STK39,UROS,MAPK8IP2,RIMS4,POLR2H,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,GPS1,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,UBE2I,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,SUCLA2,EDN1,ERBB2,CRYM,C1orf216,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,CSRNP1,SERTAD1,APOLD1,ZNF428,ITM2C,COL11A1,GSTO2,CERCAM,FCGBP,HSD17B14,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EIF6,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,C19orf53,PDE1B,FAM71E1,RTN4,CCT3,EBNA1BP2,ALAS2,CAPRIN1,ANG,B9D1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,TMEM259,KANSL3,ASNS,THBS3,CORO2B,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,NDUFB9,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,YIF1B,PLA2G2A,TRMT12,GBP4,OTUB1,VPS9D1,LMO3,SLC48A1,RNF144A,RHBDD2,GALE,BMF,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,C1QBP,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,GNG2,TALDO1,PCDHA1,GPAA1,ZNHIT1,ANKRD33,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,SFRP2,PA2G4,KIAA1191,C1orf158,ATF5,TBCB,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,WSB2,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,IL20RB,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,UQCRC1,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IP6K3,EIF4EBP3,CTSH,MCOLN3,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,UBE2Q1,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,GALK1,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TNMD,TTC23,DDX28,TRIM29,FAM96B,POMGNT2,ALDH5A1,G3BP2,HEY1,CNFN,ZNF524,PRDM11,GPM6B,CBR3,GALM,GRN,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,C19orf12,TTYH3,ABCC3,C11orf68,RBP5,SGCD,PTER,CH25H,MT2A,ABCB6,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GSTM2,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,MED9,CAPG,PGAP3,PTGDS,C9orf114,OSBPL7,RBKS,KCNG1,CBX1,ORM1,TRIM39,HIF1AN,MRPS2,CUEDC2,KLHDC4,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,SF3B5,TPR,COPE,STX6,ABCF1,CRYL1,GTF3A,NAT14,KIFC2,CCL3,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,RBPMS,SUGP2,PWWP2B,NQO1,DLEU1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CXCL16,RCAN1,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,PLIN1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,PKIA,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,CCDC170,COLEC12,CDH2,ASGR1,CD68,PTPA,SLC22A17,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,BOD1,DHRS4,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,ACSM5,SLC2A6,CMTM8,STARD13,RHOU,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,HDC,DEFB1,WDR12,CYP1B1,YBX2,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,FCER1G,S1PR1,IGF2BP2,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,TAZ,FBN2,ADSSL1,ATP5D,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,EIF5,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,RARRES1,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,SEMA3B,ALPL,CTDNEP1,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,TAF6,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,CCDC3,ZDHHC7,NDUFA13,TRIM69,WARS,PBX3,CYTIP,TSPAN1,EDNRA,RCAN2,RTN3,ASS1,PAQR7,TLE1,PGGHG,EEF1G,SLC39A8,POR,IDUA,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,TRIAP1,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,FAM136A,DPYSL4,CA4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,BCL2L1,KANK1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,NDUFS3,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,EMX2,GIMAP6,VPS25,F8,C16orf59,ISCU,EPN1,RNF26,SNTB1,TCEA3,PLAUR,SAA2,FRMD4A,ORAOV1,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,EIF3C,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,RND2,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,MT1X,TIMM17B,COMMD9,FAHD2A,KAZALD1,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,PODXL2,TSPAN14,SAC3D1,TSPAN6,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,MAFG,LCMT1,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,C5orf15,ACP2,CD302,USP36,LAGE3,IRX6,ACAP1,FAM45A,TARS,SLC39A3,GALNT13,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,RCE1,TSTD1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,DKK3,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,RPS21,C16orf58,CCDC85A,THRSP,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,CSTA,SVEP1,SYTL2,MAP6,CA5B,CACNA1H,ASCC2,TSPAN13,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,SLCO2B1,TACO1,MYL3,ALDOC,NSUN4,TSHZ2,NUP43,ALDH1B1,PDIA5,RRP1,TTC4,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,GPX7,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,CD86,GCC1,TFRC,P2RX6,SQSTM1,CHD1L,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,ZNF285,TECR,KLHDC9,IFI27,AHSA2,ASB1,RNF181,DUSP5,POFUT2,CCL2,IRF2BPL,RENBP,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,TSTA3,MED20,TJP1,GLRX2,RGS16,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,FBP1,TP53BP1,BMPER,PIN1,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,PDCD6,NBAS,PSMB5,ATF3,PKP2,RILPL1,BTG1,ZNF282,THRA,TRIM35,FOSB,GZMH,CDC42BPB,SDCBP,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,PECR,VPS37A,CCPG1,DPH5,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,CCDC107,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,ANKRD46,BSCL2,TNFRSF14,ATIC,SERPINE2,ATP6V1E1,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,FAM50B,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,ARRDC4,RPA1,SERINC1,GRAMD1A,RAD51D,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,DUS2,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PDDC1,ACSF2,FOLR2,NT5C,PFKL,SCO1,FAXDC2,TAX1BP3,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,C11orf24,LPP,SARS,COL18A1,NCKIPSD,PLAT,IL11RA,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,P4HTM,TRMT1,F11R,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,PLA2G15,XXYLT1,CLTB,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,D2HGDH,LPIN2,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,GLYAT,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,CCL18,MAP2K5,KATNB1,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,PCMT1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,MICALL1,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM222,TMEM132B,SPOCD1,FRMD1,FAM134B,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,RDH5,ZNF585A,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,GADD45B,HSDL1,ABCC9,CD69,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,SLC25A43,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,LOX,SFTPD,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,KIF3B,POLR3B,PRUNE2,CMTM4,BCAS4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,TMEM37,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,C17orf49,FAM174B,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,WDR18,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,GTPBP3,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PARM1,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C1QTNF6,KBTBD11,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,C12orf76,CD55,KIAA0040,NPIPA8 (includes others),STK24,FMO1,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,LOC401052,COLEC11,PLBD2,C2orf88,TMEM2,RHOXF1,GLMP,ACAT1,GBE1,CPZ,PDE8B,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,CAV1,ST6GALNAC2,KANK3,CEP170B,MGP,ATF4,DLG4,STK32A,EBF2,CDC16,CASQ2,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,FLOT1,TIMM8B,SMG5,THOP1,IFNAR2,BRF2,RHBDD1,TRAPPC3,ZNF579,CARD9,CTSA,IFT122,NRDE2,LRRN3,FBXW5,FSCN1,VARS2,PRELP,TRPC4AP,NCF2,MCEE,GAPDH,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,PHLDA2,GUCD1,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,LRRC20,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,SWI5,NOL12,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,FCER2,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,TRIB3,SLCO2A1,AGL,HSPA2,GLG1,PLA2G4A,SELM,NR4A2,NRXN2,SNUPN,FLNC,AIMP2,FAM129A,GPBAR1,MBD3,ATP1A2,XAF1,TMEM106C,TAF1C,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,RFXANK,UQCC3,SESN2,SLC38A10,AMDHD2,MBP,KLF6,ABCG1,C16orf91,HSPA4,MAP2K2,HDAC11,GCLM,CAST,CHTF18,CHMP1A,IER2,DOK2,GM2A,SRPRB,PSME2,ENKD1,ANO1,CYB561,KLF4,SLC25A44,ELOVL6,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,NUDT2,SH3D19,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,C4orf3,C4BPB,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,WDR41,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,ZNF404,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,MFAP2,PEX16,DGCR6L,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,NANOS1,RRBP1,PCSK5,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,GLUL,ASPHD2,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,ELOF1,GBA,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,ADGRB2,MYH1,STK19,SEMA3G,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,MIOS,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,IPO13,SPRY2,NOP2,DENND1A,LSP1,BNIP3L,CPSF3,GABARAP,NEDD9,ACTR1A,RAB3IP,RAB43,EFR3A,RGS1,PHLDA1,TFG,RCN1,XPO5,CXCL12,LIPE,CDC42EP2,TAF10,SDC4,DCAF10,MTCH2,PLEKHG4,NARS,CEL,CYP26B1,PGD,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,KLF2,GPR1,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,ERCC1,ITGAM,C9orf9,PKD1,SRPK3,SLC22A5,PLEKHH3,AK2,NFIX,RNF165,EPB41L3,PKM,PPP1CB,QPRT,TET1,GPR34,FBXO3,CDKN2B,ERV3-1,FAM110B,TNFRSF12A,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,NDUFAF3,COX17,MIPEP,CXCR4,AQP11,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,FIZ1,KIAA0930,NEK11,EXOC4,LPAR1,DIP2C,JCHAIN,ELK1,DSG2	2649	
Cellular Growth and Proliferation	proliferation	proliferation of cells	5.41E-34	Increased	3.715	 	0.145	TLE1,POR,AJUBA,GLB1,PPRC1,TSC2,SMARCB1,ETS1,RBM38,CLEC4G,DDIT4,SLX4,PLAG1,DVL2,CDH5,NPR3,PSMA4,ALCAM,mir-21,FHL1,GBP1,DDIT3,ADIPOQ,MCTS1,SYNM,DIABLO,RABL6,LLGL1,EMP3,ID3,GPR183,GPAM,SWAP70,CBS/CBSL,TBC1D8,WBP2,AKR1C3,HAVCR2,RGCC,DIRAS1,STC2,EEF1E1,BIRC3,TEK,RASGRP2,ADAMTS1,BCL2L1,AES,H3F3A/H3F3B,NDUFS3,ETV5,KCNK3,RPH3AL,ZP3,EMX2,HDGF,COL6A1,EPN1,USMG5,PLAUR,MT1A,BTK,RRAS2,ANO3,FECH,SPARC,TSC22D1,ING1,CXCL2,EFEMP2,MAP4K4,EIF3C,ASPSCR1,CTGF,CA12,SGPL1,SP110,PRG4,MTUS1,MCL1,RND2,PIK3C2B,BIRC7,DFNA5,CDKN1C,NAB1,ATG7,PRAG1,CENPB,PLEC,HBEGF,GRK5,HMGA1,THBD,NINJ1,SH3GL1,MAP3K12,GDPD5,SAC3D1,NOTCH1,NRP1,CNN2,ZFP36,LEPR,NQO2,FKBP1A,RUVBL1,MEOX2,H2AFZ,MAFG,KLF9,CST3,MEG3,TXNL1,HGS,ACVR1C,GJB2,PRPH,CD209,CD276,TRIM28,EGR1,ACLY,RELN,COPS3,SLC2A8,DHCR24,SBF1,GCAT,PTGS2,ARID4A,PRPF19,LHCGR,DNAJB2,IKBKG,PLCE1,PTGES2,ETS2,COMT,AAGAB,FST,EGR3,USP36,IRX6,PAWR,NDUFAF2,INHBB,TPSAB1/TPSB2,ZFAND3,COL6A3,SCRIB,RCE1,UVRAG,ICK,NGF,PTPRF,NELFE,RAB5A,HINT1,ARHGAP17,THBS1,MARCH8,DKK3,DUSP10,USP47,CYGB,SULF2,PARP10,HYAL1,LRRK2,EMP1,COL1A1,EBF1,PAG1,NCKAP1L,SLIT3,SPI1,ATP2A2,SLC8B1,ODC1,RCL1,GNA15,CYBA,GPRC5C,P3H1,ALDH3A1,PDIA5,DPT,MTSS1,TNFRSF10B,MAD2L2,LAMC3,HAX1,PYGO2,MN1,PPP1R15A,ARHGEF6,TFRC,CD86,AARS,SQSTM1,BYSL,ADIPOR2,PTPRA,RNF10,APOE,NME1,NACC2,PLXNA3,HCAR1,GDF15,CDK4,CEBPD,DUSP22,CTHRC1,CTDSPL,COPS8,GKN1,GADD45GIP1,DUSP5,CCL2,PLIN2,SOS1,DAB2,ASPH,ADORA1,RAD21,P4HA2,CCR1,BTNL9,S100A1,SPRY1,TJP1,RGS16,LY96,MYOC,NTRK3,SERPINH1,ATP6V0A2,FBP1,ARHGDIA,BMPER,TP53BP1,MSRA,PIN1,BMP6,PPIL1,ID4,ADRA1A,MAOA,NOC3L,NCDN,USP5,HSPA1A/HSPA1B,SLC35F6,CES2,CD163,BIN1,GPNMB,MYC,TGFBR2,NNMT,GPX3,RHOB,CXCL14,NUPR1,PDCD6,NEDD4L,PFKFB3,ATF3,PKP2,RERG,BTG1,ZNF282,VEGFC,THRA,TRIM35,DCHS1,FOSB,CDC42BPB,OGN,SDCBP,NOL3,TLN2,GIPC1,APCDD1,ALDH1A2,FZD5,MDK,PIDD1,CCPG1,ESR1,S100P,PMEPA1,INO80B,RBP4,PTGFR,FAM107A,CDC20,FRZB,MECR,ETV6,IRAK1,RAP1GDS1,HLA-DRB1,MFSD12,RGS5,AHNAK,TIMP1,MCAM,LOC102724428/SIK1,CIZ1,GJA4,SLC20A1,VCAM1,XRN2,SLC12A2,UPP1,GNAI1,ZNF16,PSME3,TNFRSF14,ATIC,SERPINE2,FAIM,SLK,CAPNS1,LOC102724788/PRODH,VAV3,CAT,TBC1D7,ISG20,SGK1,MAF,ELANE,TRAP1,CDKN2C,HOXA9,NOSIP,LPIN1,ABCC1,VEGFD,CSTF2,DNAJA3,HEY2,APEX2,RIMS3,NAT10,RPA1,MMP2,IER3,RAE1,DOCK1,SRGAP3,AQP9,VKORC1,YARS,PIP5K1C,PSMB2,MS4A4A,IL10RA,AK4,ALDOA,TRO,BACE2,PDGFD,ITGA7,DUS2,PHLPP1,ATP5G1,RALA,EMILIN2,PSMB10,CHCHD6,FOLR2,TAX1BP3,VCAN,TRIB1,CA3,MTOR,TADA3,DHPS,SRGAP1,DAP3,SOCS2,EPS15L1,PRKCE,NAA60,ACSL4,LIPG,COL18A1,NDUFAB1,PLAT,IL11RA,CYP11A1,GSTM1,SOX7,NABP1,CINP,POMGNT1,F11R,MCM2,RBM6,CHFR,PELI1,PEA15,DNPH1,SCAMP3,ZFP36L2,FZD7,CYP2C8,MVD,C10orf54,ADRBK1,VPS28,OSR1,KPNA2,LTBR,CLCN3,MYO10,ADRA1B,PTX3,CSF3R,APLNR,SPP1,GPS2,LMNA,MYOF,CORO1B,RGN,CCL18,AKR1B1,MAP2K5,LEP,NLGN1,ERN1,ANTXR1,ADSL,ZMAT3,FLNA,RPS6KB2,HSD11B2,S100A8,RNF144B,MYO16,CD59,SMAD7,MKNK2,CSF1R,ENO1,LRP1B,NDNF,UBA1,YME1L1,P2RX7,MMP9,SHMT2,CARM1,CBX7,KCNJ2,AXIN1,IL6,EIF3B,ATG9A,CCND3,CSE1L,PLXNB2,AHCY,TNFRSF21,HEYL,COMP,NKIRAS2,SURF1,GFM1,PTPN3,CTSB,ACACA,FTH1,GADD45B,DAPK2,GNA11,FNTA,DDX3X,ABCC9,UCP2,MECOM,ZNF521,CD69,IGF2R,LYN,PROCR,SOX9,LIG1,SOCS3,RARRES2,MICALL2,RABEP1,FCER1A,GPC3,CTSD,CCT5,ERAL1,KMT5A,ELN,CXCL8,NOX4,TJP2,H19,STK39,RIMS4,POLR2H,BAMBI,ERCC2,AKR1B10,TXNRD1,ADRA2A,BAP1,SYN1,VHL,UBE2I,PEBP1,SULF1,LOX,IGFBP4,LITAF,SFTPD,PC,BMP2,INPPL1,HLA-G,DHCR7,EDN1,STUB1,ERBB2,THBS4,NDUFV1,SRC,PREB,PKP1,COL6A2,G6PD,SERTAD1,RBCK1,KCND2,BMP4,TYRO3,RAN,MST1,POMC,EIF6,GSS,RAD23A,MIA,NR4A3,ITGA3,PLS3,AHSA1,IRX3,RARA,MGAT4B,AFAP1,TESK1,HADHA,SFRP4,CMKLR1,CAPN6,DKC1,JUNB,MBD2,MNDA,ROR1,RTN4,CCT3,EBNA1BP2,CAPRIN1,ANG,AKAP12,MAP7,FYN,BTG3,TTLL4,SLC1A3,ATAT1,GPC4,NAA35,ASNS,SF3B3,ENAH,EIF4EBP1,LYZ,KAT2B,JUN,RHOD,CSF2RA,CD24,WSB1,PLXNA1,RBBP9,PTPRK,CSK,CCDC8,SLIT2,AXL,DUSP14,OTUB1,LMO3,IMMT,RNF144A,GTPBP3,BMF,ATAD3A,MAMSTR,TFF3,TNFRSF4,PFN1,LAMTOR2,CD36,CD4,MAP1B,UNC5B,METAP2,WDR5,CAMK2D,SLC25A6,ALDH1A1,PLA2G5,GSK3B,C1QBP,GPC1,RET,HK1,PTPRE,GSDMB,GNG2,FZD9,AGTRAP,RASD1,ZNHIT1,APBA3,FLCN,ATPIF1,RAP1GAP,EXOSC4,PRKCD,N6AMT1,RARRES3,CD14,IDO1,CLCN7,CRABP2,SRM,SH3BP4,SFRP2,PA2G4,ATF5,CD55,NFKBIA,ANGPTL4,SMO,CFB,CDCA5,STK24,NCL,MAPKAPK2,CHEK2,ADRB2,EMILIN1,BEX2,LXN,PAK4,EPAS1,VSIG4,IL20RB,EDF1,PRMT1,IL18RAP,KIF2A,TMEM2,ACAT1,EPHB3,NUCB2,GAP43,CPEB1,KDR,TNFRSF19,CLEC10A,CAPS,CTSG,COL8A1,SERPINA3,SLC9A1,CLIP1,FADS3,BOP1,EGR2,CTSH,KIF1A,KEAP1,LUM,MGP,ST6GALNAC2,CAV1,DLG4,ATF4,HES6,HIPK2,CDC16,KAT2A,SELE,PODN,PPP1R1B,C1GALT1C1,FLOT1,NPY5R,BRF2,IFNAR2,TFPI2,HSPA8,TMEM127,IFT122,MICU1,FSCN1,BTG2,NCF2,ATMIN,GAPDH,ITGA1,PHLDA2,OSGIN1,FGF2,SEMA6A,MMP25,LAMP3,TGM2,B4GALT7,GADD45A,IL34,TNMD,CSNK2B,PIK3R2,FCGR3A/FCGR3B,HEY1,FCER2,ZNF580,NINL,CUL7,TOB1,TRIB3,GFRA2,GRN,FOS,PLA2G4A,NR4A2,AIMP2,MBD3,TAGLN,SLC22A18,MAP3K8,ABCC3,QPCT,ABCB6,MT2A,PTTG1,ITGB1BP1,MBP,PARP2,POLR3E,KLF6,OGFOD1,ABCG1,HSPA5,PADI4,HSPA4,MAP2K2,CAST,CHMP1A,MYDGF,DOK2,LAMA2,PSME2,PTGDS,ANO1,KLF4,SLC3A2,CBX1,TRIM39,ORM1,DUSP1,LIMA1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,TXNRD2,PPAN,TNFAIP8,RUNX1,DOK5,TPR,PTPMT1,COPE,STX6,ATF6,CCL3,GLRX,HNRNPK,SHC1,NET1,SAA1,RNH1,ENPP2,MCRS1,LONP1,AGT,NDUFAF4,RTKN,NQO1,SMAD6,EMD,ZPR1,CXCL16,RCAN1,HRSP12,ADGRG1,PMP22,TACC2,RPS6KA4,PLEKHA2,ALKBH3,DNM1L,NREP,NNAT,CAMK1,APOB,ITSN1,DNAJB4,TGFBR3,HRAS,NCSTN,RAPH1,NEU1,PEG10,NMUR2,NPTX2,ANK2,IRS2,TXN,WNT5B,MATK,CALCRL,NDRG1,CHN1,TUBB2A,THY1,TNK2,CTPS1,TAF9B,C9orf69,S1PR3,CDH2,TIMP4,ASGR1,CCND2,NR1D1,BSG,STIP1,SPINT2,GLUL,RSU1,MAP2K3,MAPK7,SFRP1,CYR61,ADM,SPTBN1,ADAM17,GRB14,TNFSF10,MYH11,DCLK1,VTI1B,IDH1,UCHL1,EFNB2,ID1,SEC61A1,CCL3L1,CCL3L3,STARD13,HLCS,RHOU,CLMN,SLC19A1,STIM1,TPO,RASSF5,LDLRAP1,PRPF31,SF3A2,AMFR,PI4KA,MYCN,C5AR1,UBE2M,ANGPT1,TYROBP,IMPDH2,MGMT,DPAGT1,DEFB1,WDR12,CYP1B1,B4GALT2,SUPV3L1,KRT8,TF,S100A9,CDK20,WAS,LIMS1,PPP1R16B,CNN1,NOP2,SPRY2,ADCY1,ZSCAN18,FCER1G,S1PR1,FKBP4,NR5A2,DVL3,CBX4,TAZ,GABARAP,NEDD9,FBN2,PHLDA1,TFG,SPHK2,CXCL12,TPM1,SDC4,TUBB,PARVB,CEL,PGD,G0S2,CRIP1,ITGA11,GABARAPL1,BRSK1,EIF5,NEO1,SLC7A5,KLF2,RTN4R,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,SNRK,FOXC1,PKN1,STC1,SRSF3,EFS,PPP2R1A,CCNG2,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,ASIC1,GNL3,EXTL3,AK2,NFIX,EPB41L3,VAPA,PKM,ABL1,CDH23,PPP1CB,RARRES1,TNFAIP3,TET1,SMPD1,GPR34,MYLK,IRF3,HIF1A,NAA10,AKIP1,CDKN2B,PDCD4,PRKCSH,TNFRSF12A,COL1A2,SOX17,EPHB6,HMOX1,TMEM119,AEBP1,CCL13,PCK2,CSPG4,KCNMA1,CLOCK,KIT,ARHGEF2,NSMF,NR2F6,SEMA3B,PTGER4,ACTN1,ASIP,PRNP,NDUFAF3,COX17,TAF6,MIPEP,CXCR4,AQP11,RNF126,QSOX1,SCIN,ZBTB7C,TBRG4,NDUFA13,WARS,PBX3,CYTIP,LPAR1,EXOC4,TSPAN1,P3H3,EDNRA,ELK1,RCAN2,DSG2	1044	
Cancer, Organismal Injury and Abnormalities	tumorigenesis	tumorigenesis of tissue	1.64E-33	 	-0.368	 	-0.028	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,ORM2,ANO3,SPARC,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,ABHD1,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,CNN2,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,H2AFZ,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,STAMBPL1,FCRLB,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,NIPSNAP3A,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,H2AFY2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,WDR46,EGR3,MTURN,FBXO22,SLC4A7,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,ARHGEF35,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,RRM2B,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,C9orf24,CEBPD,CDK4,CTDSPL,SDHAF1,GADD45GIP1,PNPO,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,NTMT1,PPFIBP2,SLC41A2,RNASE1,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,RERG,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,RPLP1,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,CTAGE9 (includes others),RNLS,CANX,N4BP1,PNCK,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,DNAJA3,CSTF2,HEY2,GUCY1A3,NAT10,MMP2,IER3,SCNN1D,RAE1,SERINC2,DOCK1,AQP9,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,PSMB10,CHCHD6,KAZN,KHDC1,VCAN,SERTAD4,CA3,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,FAM86C1,RBM6,ADCK2,CHFR,DBNL,VPS52,CYP2C8,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,LMO4,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,PROCR,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,POLR2H,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,UBE2I,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,SUCLA2,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,CERCAM,FCGBP,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EIF6,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,C19orf53,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,TMEM259,KANSL3,THBS3,CORO2B,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,NDUFB9,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,YIF1B,PLA2G2A,TRMT12,GBP4,OTUB1,SLC48A1,RHBDD2,GALE,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,C1QBP,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,ANKRD33,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,SFRP2,PA2G4,KIAA1191,ATF5,TBCB,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,PERP,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,EPHB3,NUCB2,GPR160,GAP43,UQCRC1,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IP6K3,EIF4EBP3,CTSH,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,FAM96B,POMGNT2,ALDH5A1,G3BP2,HEY1,CNFN,ZNF524,PRDM11,GPM6B,CBR3,GALM,GRN,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,C19orf12,TTYH3,ABCC3,C11orf68,RBP5,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,PTGDS,C9orf114,OSBPL7,KCNG1,CBX1,TRIM39,ORM1,HIF1AN,MRPS2,KLHDC4,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,SF3B5,TPR,COPE,STX6,ABCF1,GTF3A,NAT14,KIFC2,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,ASGR1,CD68,PTPA,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,BOD1,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,ACSM5,SLC2A6,CMTM8,STARD13,RHOU,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,DEFB1,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,FCER1G,S1PR1,IGF2BP2,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,TAZ,FBN2,ADSSL1,ATP5D,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,SEMA3B,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,CCDC3,ZDHHC7,NDUFA13,WARS,CYTIP,EDNRA,RCAN2,RTN3,ASS1,PAQR7,TLE1,EEF1G,SLC39A8,POR,IDUA,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,FAM136A,CA4,DPYSL4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,ORAOV1,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,EIF3C,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,LDHD,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,TSPAN14,SAC3D1,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,LCMT1,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,RPS21,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,CSTA,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,TSPAN13,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,SLCO2B1,TACO1,MYL3,ALDOC,NSUN4,TSHZ2,NUP43,PDIA5,ALDH1B1,TTC4,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,PPP1R15A,ARHGEF6,PHF23,CD86,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,IFI27,AHSA2,ASB1,RNF181,DUSP5,POFUT2,CCL2,IRF2BPL,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,TP53BP1,BMPER,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,PDCD6,NBAS,PKP2,RILPL1,ZNF282,THRA,TRIM35,FOSB,GZMH,CDC42BPB,SDCBP,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,PECR,VPS37A,CCPG1,DPH5,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,CCDC107,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,DUS2,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PAM16,PDDC1,ACSF2,FOLR2,NT5C,PFKL,SCO1,FAXDC2,TAX1BP3,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,PLA2G15,XXYLT1,CLTB,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,D2HGDH,LPIN2,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,MAP2K5,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,PCMT1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM222,TMEM132B,SPOCD1,FRMD1,FAM134B,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,GADD45B,HSDL1,ABCC9,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,SLC25A43,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,LOX,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,KIF3B,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,TMEM37,CMKLR1,RPL7L1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,FAM174B,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,GTPBP3,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,KIAA0040,NPIPA8 (includes others),STK24,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,LOC401052,COLEC11,PLBD2,C2orf88,TMEM2,RHOXF1,GLMP,ACAT1,GBE1,CPZ,PDE8B,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,CAV1,ST6GALNAC2,KANK3,CEP170B,MGP,ATF4,DLG4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,FLOT1,TIMM8B,SMG5,THOP1,IFNAR2,BRF2,RHBDD1,TRAPPC3,ZNF579,CARD9,CTSA,IFT122,NRDE2,LRRN3,FBXW5,FSCN1,VARS2,PRELP,TRPC4AP,NCF2,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,SWI5,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,FCER2,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,TRIB3,SLCO2A1,AGL,HSPA2,GLG1,PLA2G4A,SELM,NR4A2,NRXN2,SNUPN,FLNC,FAM129A,GPBAR1,MBD3,ATP1A2,XAF1,TMEM106C,TAF1C,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,RFXANK,UQCC3,SESN2,SLC38A10,AMDHD2,MBP,KLF6,ABCG1,C16orf91,MAP2K2,HDAC11,GCLM,CAST,CHTF18,DOK2,GM2A,SRPRB,PSME2,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,NUDT2,SH3D19,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,C4orf3,C4BPB,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,WDR41,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,ZNF404,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,STK19,SEMA3G,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,IPO13,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,TAF10,SDC4,DCAF10,MTCH2,PLEKHG4,CEL,CYP26B1,ASXL2,ZSWIM1,IP6K1,C14orf180,GPR1,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,ERCC1,ITGAM,C9orf9,PKD1,SRPK3,SLC22A5,PLEKHH3,AK2,NFIX,RNF165,EPB41L3,PKM,PPP1CB,QPRT,TET1,GPR34,FBXO3,CDKN2B,ERV3-1,FAM110B,TNFRSF12A,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,COX17,MIPEP,CXCR4,AQP11,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,KIAA0930,NEK11,EXOC4,LPAR1,DIP2C,JCHAIN,ELK1,DSG2	2498	
Cancer, Organismal Injury and Abnormalities	neoplasia	neoplasia of epithelial tissue	2.84E-32	 	-0.455	 	-0.021	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,ABHD1,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,CNN2,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,H2AFZ,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,H2AFY2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,WDR46,EGR3,MTURN,FBXO22,SLC4A7,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,ARHGEF35,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,C9orf24,CEBPD,CDK4,CTDSPL,SDHAF1,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,NTMT1,PPFIBP2,SLC41A2,RNASE1,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,CTAGE9 (includes others),RNLS,CANX,N4BP1,PNCK,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,DNAJA3,CSTF2,GUCY1A3,NAT10,MMP2,IER3,SCNN1D,RAE1,SERINC2,DOCK1,AQP9,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,PSMB10,CHCHD6,KAZN,KHDC1,VCAN,SERTAD4,CA3,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,FAM86C1,RBM6,ADCK2,CHFR,DBNL,VPS52,CYP2C8,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,LMO4,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,PROCR,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,UBE2I,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,CERCAM,FCGBP,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EIF6,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,TMEM259,KANSL3,THBS3,CORO2B,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,NDUFB9,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,YIF1B,PLA2G2A,TRMT12,GBP4,OTUB1,SLC48A1,RHBDD2,GALE,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,C1QBP,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,ANKRD33,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,SFRP2,PA2G4,KIAA1191,ATF5,TBCB,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,PERP,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IP6K3,EIF4EBP3,CTSH,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,FAM96B,POMGNT2,ALDH5A1,G3BP2,HEY1,CNFN,ZNF524,PRDM11,GPM6B,CBR3,GALM,GRN,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,C19orf12,TTYH3,ABCC3,C11orf68,RBP5,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,PTGDS,OSBPL7,C9orf114,KCNG1,CBX1,TRIM39,ORM1,HIF1AN,MRPS2,KLHDC4,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,SF3B5,TPR,COPE,STX6,ABCF1,GTF3A,NAT14,KIFC2,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,ASGR1,CD68,PTPA,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,BOD1,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,ACSM5,SLC2A6,CMTM8,STARD13,RHOU,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,DEFB1,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,IGF2BP2,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,FBN2,ADSSL1,ATP5D,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,CCDC3,ZDHHC7,NDUFA13,WARS,CYTIP,EDNRA,RTN3,RCAN2,ASS1,PAQR7,TLE1,EEF1G,SLC39A8,POR,IDUA,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,FAM136A,CA4,DPYSL4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,ORAOV1,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,EIF3C,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,LDHD,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,TSPAN14,SAC3D1,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,RPS21,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,CSTA,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,TSPAN13,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,SLCO2B1,TACO1,MYL3,ALDOC,NSUN4,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,PPP1R15A,ARHGEF6,PHF23,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,IFI27,AHSA2,ASB1,RNF181,DUSP5,POFUT2,CCL2,IRF2BPL,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,TP53BP1,BMPER,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,PDCD6,NBAS,PKP2,RILPL1,ZNF282,THRA,TRIM35,FOSB,GZMH,CDC42BPB,SDCBP,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,DPH5,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,CCDC107,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,DUS2,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PAM16,PDDC1,ACSF2,FOLR2,NT5C,PFKL,SCO1,FAXDC2,TAX1BP3,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,PLA2G15,XXYLT1,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,D2HGDH,LPIN2,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,MAP2K5,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,PCMT1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM222,TMEM132B,SPOCD1,FRMD1,FAM134B,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,GADD45B,HSDL1,ABCC9,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,LOX,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,KIF3B,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,TMEM37,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,FAM174B,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,GTPBP3,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,KIAA0040,STK24,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,LOC401052,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,CPZ,PDE8B,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,CAV1,ST6GALNAC2,KANK3,CEP170B,MGP,ATF4,DLG4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,FLOT1,TIMM8B,SMG5,THOP1,IFNAR2,BRF2,RHBDD1,TRAPPC3,ZNF579,CARD9,CTSA,IFT122,NRDE2,LRRN3,FBXW5,FSCN1,VARS2,PRELP,TRPC4AP,NCF2,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,SWI5,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,FCER2,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,TRIB3,SLCO2A1,AGL,HSPA2,GLG1,PLA2G4A,SELM,NR4A2,NRXN2,SNUPN,FLNC,FAM129A,GPBAR1,MBD3,ATP1A2,XAF1,TMEM106C,TAF1C,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,UQCC3,SESN2,SLC38A10,AMDHD2,MBP,KLF6,ABCG1,C16orf91,MAP2K2,HDAC11,GCLM,CAST,CHTF18,DOK2,GM2A,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,NUDT2,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,C4orf3,C4BPB,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,WDR41,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,ZNF404,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,STK19,SEMA3G,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,IPO13,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,TAF10,SDC4,DCAF10,MTCH2,PLEKHG4,CEL,CYP26B1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,ERCC1,ITGAM,C9orf9,PKD1,SRPK3,SLC22A5,PLEKHH3,AK2,NFIX,RNF165,EPB41L3,PKM,PPP1CB,QPRT,TET1,GPR34,FBXO3,CDKN2B,FAM110B,TNFRSF12A,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,COX17,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,KIAA0930,NEK11,EXOC4,LPAR1,DIP2C,JCHAIN,ELK1,DSG2	2467	
Cell Death and Survival	necrosis	necrosis	2.13E-29	Decreased	-3.572	 	-2.302	ASS1,VAC14,TSC2,SMARCB1,ETS1,DDIT4,DVL2,HLA-DRB4,CDH5,PSMA4,ALCAM,TRIAP1,mir-21,DDIT3,ADIPOQ,MCTS1,DIABLO,RABL6,ATN1,EMP3,ID3,GPAM,SWAP70,CBS/CBSL,HAVCR2,DPYSL4,CA4,DNAJC15,CBX5,CARD8,BIRC3,NSMAF,TEK,ADAMTS1,SGCB,STX1A,BCL2L1,NAGLU,MLKL,SUN1,KCNK3,HDGF,COL6A1,ISCU,NLRP3,PLAUR,MT1A,BTK,RRAS2,SPARC,TSC22D1,CYB5A,ING1,CXCL2,RPLP0,GFPT1,EIF3C,MSRB2,CTGF,GMDS,SGPL1,MTUS1,MCL1,BIRC7,ATG7,CDKN1C,MT1X,CENPB,PLEC,HBEGF,FAHD2A,HMGA1,THBD,MAP3K12,NOTCH1,TMEM158,NRP1,CNN2,ZFP36,LEPR,NQO2,SIN3B,FKBP1A,CASP4,MEOX2,KLF9,LCMT1,CST3,ACVR1C,GJB2,RPS24,PRPH,TRIM28,EGR1,ACLY,SRXN1,DHCR24,PTGS2,PRPF19,AS3MT,DNAJB2,IKBKG,PLCE1,ETS2,COMT,FST,EGR3,PAWR,TPSAB1/TPSB2,ITPK1,NGF,PTPRF,HINT1,MAN2C1,MARCH8,DKK3,THBS1,SULF2,FAM162A,ATP2C1,HYAL1,LRRK2,RPS21,EMP1,FAF1,COL1A1,EBF1,MT1F,SLC47A1,SLIT3,CSTA,RRM2B,CACNA1H,SPI1,ATP2A2,ODC1,EMG1,NUP93,CYBA,ALDH3A1,CERS6,TNFRSF10B,MAD2L2,RPAP3,DCTD,GPX7,HAX1,TNPO2,ARHGEF6,PPP1R15A,TFRC,CD86,SQSTM1,AARS,PTPRA,APOE,NME1,NACC2,HCAR1,GDF15,CDK4,CEBPD,MTFP1,CCL2,DAB2,ADORA1,HCAR2,RAD21,LIG3,S100A1,SIGMAR1,RGS16,MYOC,LDLR,NTRK3,SERPINH1,TPP1,TP53BP1,ARHGDIA,PIN1,BMP6,ADRA1A,MAOA,ISM1,RTN1,ACO2,HSPA1A/HSPA1B,TYMP,RNASE1,TGFBR2,MYC,RHOB,NUPR1,GIMAP5,GULP1,PFKFB3,ATF3,PSMB5,PKP2,BTG1,VEGFC,THRA,FOSB,GZMH,NOL3,PLEKHF1,ALDH1A2,SORCS2,MDK,PIDD1,ESR1,DPH5,PMEPA1,RBP4,S100P,SRPX,FRZB,CDC20,ETV6,RAP1GDS1,IRAK1,RGS5,TIMP1,MCAM,LOC102724428/SIK1,ATP13A2,SLC20A1,PARVA,VCAM1,PSME3,NFE2L1,TNFRSF14,SERPINE2,SH3PXD2A,FAIM,SLK,LOC102724788/PRODH,CAPNS1,VAV3,CAT,SGK1,COX8A,TRAP1,ELANE,SH3GLB1,CDKN2C,HOXA9,APRT,SPTLC2,ABCC1,ZHX2,DNAJA3,FANCG,STOML2,MMP2,RPA1,IER3,RAD51D,DOCK1,YARS,ALDOA,RPL6,PDGFD,ITGA7,PHLPP1,EMILIN2,PSMB10,KAZN,VCAN,TRIB1,CA3,MTOR,DAP3,PRKCE,COL18A1,NDUFAB1,IL11RA,PLAT,CYP11A1,GSTM1,NABP1,COL5A3,LAMP2,MCM2,SLC25A19,PEA15,CYP2C8,SERPINI1,VPS28,ADRBK1,ARG2,PRND,SIAH2,KPNA2,LTBR,CCDC86,DDX41,CSF3R,SPP1,NUP155,GPS2,LMO4,SGCG,ITPR2,LMNA,DPP9,RPL9,GSR,RGN,AKR1B1,MAP2K5,LEP,ERN1,BCL2L12,ANTXR1,ZMAT3,FLNA,RPS6KB2,HSD11B2,S100A8,PSMA3,RNF144B,CD59,FAM134B,SMAD7,F13A1,CSF1R,ENO1,NDNF,UBA1,YME1L1,MMP9,P2RX7,AXIN1,C1QA,IL6,EIF3B,CCND3,CSE1L,TNFRSF21,PTGIS,HEYL,COMP,SURF1,PDLIM7,CTSB,ACACA,EPHX1,FTH1,TUFM,GADD45B,PSMD7,DAPK2,GNA11,FNTA,DDX3X,ABCC9,UCP2,MECOM,CD69,IGF2R,HNRNPH1,PROCR,LYN,SOX9,LIG1,SOCS3,FCER1A,GPC3,CEP104,CTSD,CCT5,WDR4,CXCL8,STXBP1,NOX4,TJP2,POLR2H,ERCC2,TXNRD1,BAP1,SLC25A10,CCDC80,VHL,UBE2I,PEBP1,IGFBP4,SULF1,SFTPD,NELFB,BMP2,INPPL1,HLA-G,ALDH2,DHCR7,EDN1,STUB1,ERBB2,SRC,THBS4,G6PD,RBCK1,KCND2,BMP4,TYRO3,RAN,MST1,POMC,EIF6,COMMD4,MIA,NR4A3,ITGA3,LGMN,AHSA1,RARA,AFAP1,HADHA,SFRP4,CAPN6,JUNB,NLRX1,RNASEH2A,ROR1,DPH2,PDE1B,RTN4,CCT3,EBNA1BP2,CAPRIN1,ANG,AKAP12,FYN,GSTM5,BTG3,SLC1A3,HYOU1,NAA35,ASNS,SF3B3,EIF4EBP1,MCOLN1,LYZ,JUN,CES1,CSF2RA,CD24,WSB1,CSK,ARHGAP4,CCDC8,SLIT2,AXL,BRMS1,OTUB1,IMMT,BMF,TFF3,TNFRSF4,PFN1,LAMTOR2,CD4,CD36,UNC5B,MAP1B,METAP2,SLC25A6,ALDH1A1,CAMK2D,PLA2G5,GPC1,GSK3B,BCKDK,RET,FZD2,HK1,PTPRE,SHARPIN,HSPA9,GNG2,RASD1,RAP1GAP,PRKCD,CD14,IDO1,CLCN7,CRABP2,SFRP2,PA2G4,ATF5,CD55,NFKBIA,HSPE1,SMO,NCL,MAPKAPK2,IFRD1,CHEK2,RHBDD3,ADRB2,BEX2,PAK4,EPAS1,SNRPB,PERP,AVPI1,PRMT1,ACAT1,GBE1,KDR,TNFRSF19,CLEC10A,CTSG,SERPINA3,SLC9A1,EGR2,MCOLN3,KIF1A,KEAP1,LUM,CAV1,DLG4,ATF4,HIPK2,UNG,PIGT,SELE,UBE2Q1,PPP1R1B,IFNAR2,TFPI2,HSPA8,CARD9,NCF2,BTG2,ATMIN,GAPDH,ITGA1,OSGIN1,FGF2,SEMA6A,GRINA,TGM2,GADD45A,CS,IL17D,PIK3R2,TRIM29,FCGR3A/FCGR3B,FCER2,MAPKAP1,CUL7,TRIB3,GFRA2,ST3GAL3,GRN,PLA2G4A,FOS,NR4A2,AIMP2,ATP1A2,XAF1,MAP3K8,SGCD,MT2A,RFXANK,ATP2B1,SESN2,MBP,PTTG1,POLR3E,KLF6,PARP2,OGFOD1,ABCG1,STYXL1,HSPA5,AP2A2,PADI4,HSPA4,HDAC11,CAST,GCLM,UNC13B,LAMA2,PPP1R11,PTGDS,KLF4,SLC3A2,TRIM39,DUSP1,HIF1AN,IGFBP3,AGAP3,ALDH3B1,CAPN2,RUNX1,TNFAIP8,PTPMT1,TPR,CADPS2,ATF6,CCL3,GLRX,HNRNPK,CIAPIN1,SLC19A3,SHC1,SAA1,MCRS1,LONP1,AGT,NDUFAF4,RTKN,NQO1,SMAD6,EMD,RCAN1,PMP22,CIDEA,IRF2BP2,PIGB,CDC34,DNM1L,ALKBH3,NNAT,APOB,DPYD,ITSN1,TGFBR3,HRAS,MIF4GD,SATB2,IRS2,TXN,EYA2,CALCRL,NDRG1,THY1,TNK2,LDOC1,S1PR3,TIMP4,CDH2,CCND2,BSG,NR1D1,STIP1,MAP2K3,SFRP1,MAPK7,CYR61,SPTBN1,MME,ADM,HIST1H1C,ADAM17,RAB32,TNFSF10,MYH11,VTI1B,UCHL1,FANCE,ID1,EFNB2,ACSM5,GBA,CCL3L3,PSMD14,STIM1,LBP,RASSF5,PCBP2,PTPRT,MBOAT7,MYCN,ADRM1,C5AR1,ANGPT1,UBE2M,TYROBP,MGMT,DEFB1,CYP1B1,KRT8,S100A9,TF,LIMS1,WAS,SPRY2,LSP1,FKBP4,MS4A2,IGF2BP2,S1PR1,FCER1G,BNIP3L,NR5A2,NEDD9,PHLDA1,PFKFB1,SPHK2,CXCL12,LIPE,TPM1,SDC4,TUBB,CCT8,CEL,TNIP1,G0S2,IP6K1,NEO1,PUF60,KLF2,RTN4R,EIF2AK1,IGFBP6,MIF,DNASE2,SNRK,PKN1,STC1,PPP2R1A,ERCC1,ITGAM,PKD1,SMOX,GNL3,NFIX,PKM,VAPA,ABL1,TNFAIP3,MYLK,SMPD1,HIF1A,IRF3,PDCD4,SOX17,EPHB6,HMOX1,PCK2,KCNMA1,CSPG4,CLOCK,C7,KIT,NEK7,NSMF,SEMA3B,HCST,CUL9,PTGER4,PI4KB,PRNP,FAAH,TAF6,CXCR4,AQP11,TRIP6,SCIN,NFKBIZ,NDUFA13,NEK11,LPAR1,PBX3,EDNRA,ELK1,RCAN2,DSG2	771	
Cancer, Organismal Injury and Abnormalities	epithelial cancer	epithelial cancer	4.20E-29	 	-0.401	 	-0.130	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,GPC6,MTSS1L,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,ABHD1,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,CNN2,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,H2AFZ,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,H2AFY2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,WDR46,EGR3,MTURN,FBXO22,SLC4A7,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,ARHGEF35,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,C9orf24,CEBPD,CDK4,CTDSPL,SDHAF1,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,PPFIBP2,SLC41A2,RNASE1,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,CTAGE9 (includes others),RNLS,CANX,N4BP1,PNCK,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,DNAJA3,CSTF2,GUCY1A3,NAT10,MMP2,IER3,SCNN1D,RAE1,SERINC2,DOCK1,AQP9,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,PSMB10,CHCHD6,KAZN,KHDC1,VCAN,SERTAD4,CA3,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,FAM86C1,RBM6,ADCK2,CHFR,DBNL,VPS52,CYP2C8,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,LMO4,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,PROCR,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,CERCAM,FCGBP,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EIF6,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,TMEM259,KANSL3,THBS3,CORO2B,SF3B3,GPIHBP1,SDCCAG3,TIGD5,CELF1,RPUSD3,STOM,NDUFB9,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,YIF1B,TRMT12,GBP4,OTUB1,SLC48A1,RHBDD2,GALE,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,C1QBP,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,ANKRD33,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,SFRP2,PA2G4,KIAA1191,ATF5,TBCB,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IP6K3,EIF4EBP3,CTSH,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,FAM96B,POMGNT2,ALDH5A1,G3BP2,HEY1,CNFN,ZNF524,PRDM11,GPM6B,CBR3,GALM,GRN,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,C19orf12,TTYH3,ABCC3,C11orf68,RBP5,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,OSBPL7,C9orf114,KCNG1,CBX1,TRIM39,ORM1,HIF1AN,MRPS2,KLHDC4,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,SF3B5,TPR,COPE,STX6,ABCF1,GTF3A,NAT14,KIFC2,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,ASGR1,CD68,PTPA,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,BOD1,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,ACSM5,SLC2A6,CMTM8,STARD13,RHOU,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,DEFB1,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,IGF2BP2,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,FBN2,ADSSL1,ATP5D,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,CCDC3,ZDHHC7,NDUFA13,WARS,CYTIP,EDNRA,RTN3,ASS1,PAQR7,TLE1,EEF1G,SLC39A8,POR,IDUA,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,FAM136A,CA4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,ORAOV1,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,EIF3C,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,TSPAN14,SAC3D1,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,NAP1L4,SLC25A13,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,RPS21,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,CSTA,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,TSPAN13,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,SLCO2B1,TACO1,MYL3,ALDOC,NSUN4,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,IFI27,AHSA2,ASB1,RNF181,DUSP5,POFUT2,CCL2,IRF2BPL,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,TP53BP1,BMPER,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,PDCD6,NBAS,PKP2,RILPL1,ZNF282,THRA,TRIM35,FOSB,GZMH,CDC42BPB,SDCBP,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,DPH5,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,CCDC107,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,DUS2,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PDDC1,ACSF2,FOLR2,NT5C,PFKL,SCO1,FAXDC2,TAX1BP3,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,PLA2G15,XXYLT1,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,D2HGDH,LPIN2,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,MAP2K5,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,PCMT1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM222,TMEM132B,SPOCD1,FRMD1,FAM134B,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,GADD45B,HSDL1,ABCC9,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,LOX,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,KIF3B,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,CMKLR1,TMEM37,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,FAM174B,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,GTPBP3,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,KIAA0040,STK24,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,LOC401052,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,CPZ,PDE8B,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,CAV1,ST6GALNAC2,KANK3,CEP170B,MGP,ATF4,DLG4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,FLOT1,TIMM8B,SMG5,THOP1,IFNAR2,BRF2,RHBDD1,TRAPPC3,ZNF579,CARD9,CTSA,IFT122,NRDE2,LRRN3,FBXW5,FSCN1,VARS2,PRELP,TRPC4AP,NCF2,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,SWI5,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,FCER2,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,TRIB3,SLCO2A1,AGL,HSPA2,GLG1,PLA2G4A,SELM,NR4A2,NRXN2,SNUPN,FLNC,FAM129A,GPBAR1,MBD3,ATP1A2,XAF1,TMEM106C,TAF1C,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,UQCC3,SESN2,SLC38A10,AMDHD2,MBP,KLF6,ABCG1,C16orf91,MAP2K2,HDAC11,GCLM,CAST,CHTF18,DOK2,GM2A,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,NUDT2,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,C4orf3,C4BPB,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,WDR41,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,ZNF404,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,STK19,SEMA3G,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,IPO13,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,TAF10,SDC4,DCAF10,MTCH2,PLEKHG4,CEL,CYP26B1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,C9orf9,ITGAM,ERCC1,SRPK3,PKD1,SLC22A5,PLEKHH3,AK2,NFIX,RNF165,EPB41L3,PKM,PPP1CB,QPRT,TET1,GPR34,FBXO3,CDKN2B,FAM110B,TNFRSF12A,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,COX17,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,KIAA0930,NEK11,EXOC4,LPAR1,DIP2C,ELK1,DSG2	2441	
Cell Death and Survival	cell death	cell death	6.61E-29	Decreased	-3.964	 	-2.059	ASS1,VAC14,POR,IDUA,TSC2,SMARCB1,ETS1,DDIT4,SLX4,DVL2,HLA-DRB4,CDH5,PSMA4,ALCAM,TRIAP1,BRE,mir-21,DDIT3,ADIPOQ,MCTS1,DIABLO,RABL6,GNG5,ATN1,EMP3,ID3,GPAM,SWAP70,CBS/CBSL,AKR1C3,CA4,DPYSL4,HAVCR2,DNAJC15,CBX5,INTS1,CARD8,EEF1E1,MTMR2,BIRC3,NSMAF,TEK,RASGRP2,ADAMTS1,SGCB,STX1A,BCL2L1,AES,H3F3A/H3F3B,NAGLU,MLKL,SUN1,ETV5,KCNK3,EMX2,HDGF,COL6A1,ISCU,NLRP3,PLAUR,MT1A,BTK,RRAS2,SPARC,TSC22D1,CYB5A,ING1,CXCL2,MAP4K4,RPLP0,EIF3C,GFPT1,MSRB2,CTGF,GMDS,SGPL1,SP110,MTUS1,MCL1,BIRC7,CDKN1C,ATG7,CENPB,MT1X,PLEC,FAHD2A,HBEGF,GRK5,HMGA1,THBD,NINJ1,MAP3K12,NOTCH1,TMEM158,NRP1,CNN2,SORL1,ZFP36,LEPR,NQO2,SIN3B,FKBP1A,CASP4,MEOX2,ATP6AP1,MAFG,KLF9,LCMT1,CST3,TUB,ACVR1C,GJB2,RPS24,PRPH,TRIM28,EGR1,ACLY,SRXN1,DHCR24,PTGS2,PRPF19,CLIP3,LHCGR,AS3MT,DNAJB2,IKBKG,PLCE1,ETS2,COMT,FST,ACP2,EGR3,SLC4A7,PAWR,TPSAB1/TPSB2,ITPK1,SCRIB,UTP11,HIGD1A,NGF,PTPRF,RAB5A,HINT1,MAN2C1,MARCH8,DKK3,THBS1,DUSP10,USP47,SULF2,FAM162A,ATP2C1,HYAL1,LRRK2,RPS21,EMP1,FAF1,COL1A1,EBF1,MT1F,NCKAP1L,SLC47A1,SLIT3,CSTA,RRM2B,CACNA1H,SPI1,ATP2A2,ODC1,EMG1,GATAD2A,NUP93,CYBA,ALDH3A1,ALDOC,CERS6,TNFRSF10B,MAD2L2,RPAP3,DCTD,GPX7,HAX1,WDR81,TNPO2,PPP1R15A,ARHGEF6,TFRC,CD86,AARS,SQSTM1,PTPRA,APOE,NME1,SLC4A2,NACC2,FBXO10,HCAR1,GDF15,CDK4,CEBPD,DUSP22,MTFP1,IFI27,GADD45GIP1,CCL2,DAB2,ADORA1,HCAR2,RAD21,LIG3,TSTA3,S100A1,SIGMAR1,RGS16,SDF2L1,ZFPM2,MYOC,LDLR,NTRK3,SERPINH1,TPP1,ARHGDIA,TP53BP1,AFG3L2,PIN1,BMP6,ADRA1A,MAOA,ISM1,RTN1,ABCA3,HSPA1A/HSPA1B,ACO2,TYMP,RNASE1,BIN1,CEBPG,MYC,TGFBR2,RHOB,GIMAP5,NUPR1,PDCD6,GULP1,PFKFB3,PSMB5,ATF3,PKP2,BTG1,VEGFC,THRA,TRIM35,ARSA,FOSB,GZMH,NOL3,PLEKHF1,ALDH1A2,SORCS2,MDK,PIDD1,ESR1,DPH5,S100P,PMEPA1,RBP4,PTGFR,SRPX,FRZB,CDC20,SLC2A3,ETV6,IRAK1,RAP1GDS1,HLA-DRB1,RGS5,TIMP1,MCAM,COQ8A,LOC102724428/SIK1,ATP13A2,SLC20A1,NUSAP1,PARVA,VCAM1,SLC12A2,GNAI1,CANX,ZNF16,PSME3,NFE2L1,TNFRSF14,SERPINE2,SH3PXD2A,FAIM,SLK,LOC102724788/PRODH,CAPNS1,VAV3,CAT,ISG20,SGK1,COX8A,MAF,TRAP1,ELANE,SH3GLB1,CDKN2C,HOXA9,APRT,SLC4A3,SPTLC2,ABCC1,ZHX2,DNAJA3,FANCG,STOML2,MMP2,RPA1,IER3,RAD51D,RAE1,DOCK1,AQP9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,PDGFD,DUS2,ITGA7,PHLPP1,EMILIN2,PSMB10,PAM16,KAZN,VCAN,TRIB1,CA3,MTOR,TADA3,ALDH1A3,ANXA5,DAP3,SOCS2,PRKCE,ACSL4,COL18A1,NDUFAB1,IL11RA,PLAT,CYP11A1,GSTM1,NABP1,COL5A3,LAMP2,MCM2,SLC25A19,PEA15,ZFP36L2,CYP2C8,SERPINI1,VPS28,ADRBK1,FNIP2,ARG2,OSR1,PRND,KPNA2,SIAH2,LTBR,CCDC86,CLCN3,DDX41,ADRA1B,CSF3R,SPP1,NUP155,GPS2,LMO4,SGCG,ITPR2,LMNA,RPL9,DPP9,GSR,RGN,AKR1B1,KATNB1,MAP2K5,LEP,PRDX5,ERN1,PCMT1,BCL2L12,ANTXR1,ZMAT3,FLNA,RPS6KB2,HSD11B2,PSMA3,S100A8,RNF144B,CD59,FAM134B,SMAD7,F13A1,CSF1R,ENO1,NDNF,UBA1,YME1L1,P2RX7,MMP9,CBX7,AXIN1,C1QA,IL6,NPAS2,EIF3B,CCND3,CSE1L,TNFRSF21,FBL,PTGIS,HEYL,COMP,SURF1,PDLIM7,CTSB,ACACA,PLTP,FTH1,EPHX1,TUFM,GADD45B,PSMD7,DAPK2,GNA11,FNTA,DDX3X,ABCC9,UCP2,MECOM,APBB3,CD69,PVR,IGF2R,CSTB,HNRNPH1,LYN,PROCR,SOX9,LIG1,SOCS3,FCER1A,GPC3,CEP104,CTSD,AK1,CCT5,WDR4,KMT5A,CXCL8,NOX4,STXBP1,TJP2,POLR2H,ERCC2,TXNRD1,BAP1,SLC25A10,CCDC80,VHL,UBE2I,PEBP1,SULF1,IGFBP4,SFTPD,NELFB,DNASE1L3,BMP2,INPPL1,HLA-G,ALDH2,DHCR7,EDN1,STUB1,ERBB2,THBS4,SRC,G6PD,CSRNP1,RBCK1,KCND2,DDX11,BMP4,TYRO3,RAN,MST1,POMC,EIF6,GSS,COMMD4,MIA,NR4A3,ITGA3,AHSA1,LGMN,RARA,AFAP1,HADHA,SFRP4,CAPN6,ZC3HC1,JUNB,MNDA,RNASEH2A,NLRX1,ROR1,BCAP29,DPH2,EPB42,PDE1B,RTN4,CCT3,EBNA1BP2,CAPRIN1,ANG,AKAP12,FYN,GSTM5,BTG3,HYOU1,SLC1A3,ATAT1,NAA35,ASNS,SF3B3,EIF4EBP1,MCOLN1,LYZ,CES1,JUN,KAT2B,CSF2RA,CD24,WSB1,CSK,ARHGAP4,CCDC8,SLIT2,BRMS1,AXL,PLA2G2A,OTUB1,IMMT,BMF,ATAD3A,TFF3,TNFRSF4,PFN1,LAMTOR2,CD36,CD4,MAP1B,UNC5B,METAP2,CAMK2D,SLC25A6,ALDH1A1,PLA2G5,GSK3B,C1QBP,GPC1,RET,HLA-F,BCKDK,FZD2,STX11,FERMT3,HK1,PTPRE,SHARPIN,HSPA9,GNG2,RASD1,FLCN,RAP1GAP,PRKCD,CD14,IDO1,CLCN7,CRABP2,SFRP2,PA2G4,ATF5,CD55,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,STK24,NCL,MAPKAPK2,IFRD1,CHEK2,ADRB2,RHBDD3,BEX2,PAK4,EPAS1,SNRPB,BHLHE41,PHLDA3,P2RX4,PERP,AVPI1,PRMT1,ACAT1,GBE1,C6,CPEB1,KDR,TNFRSF19,CLEC10A,CTSG,SERPINA3,SLC9A1,NSF,EGR2,CTSH,MCOLN3,KIF1A,KEAP1,LUM,MGP,CAV1,DLG4,ATF4,HIPK2,KAT2A,UNG,CASQ2,VPS4B,PIGT,SELE,UBE2Q1,PPP1R1B,CIDEC,C1GALT1C1,ANO6,NPY5R,RHBDD1,IFNAR2,TFPI2,HSPA8,CARD9,IFT122,BTG2,NCF2,ATMIN,GAPDH,ITGA1,PHLDA2,OSGIN1,FGF2,SEMA6A,GRINA,TGM2,CS,GADD45A,IL17D,PIK3R2,TRIM29,FCGR3A/FCGR3B,HEY1,FCER2,MAPKAP1,CUL7,TRIB3,GFRA2,GPM6B,ST3GAL3,HSPA2,GRN,FOS,PLA2G4A,HP,NR4A2,AIMP2,ATP1A2,XAF1,NLE1,MAP3K8,ABCC3,SGCD,RFXANK,MT2A,SESN2,ATP2B1,MBP,PTTG1,POLR3E,DPP7,KLF6,PARP2,OGFOD1,ABCG1,STYXL1,HSPA5,AP2A2,PADI4,HSPA4,MAP2K2,HDAC11,GCLM,CHTF18,CAST,MYDGF,UNC13B,LAMA2,PSME2,PPP1R11,C9orf114,PTGDS,KLF4,SLC3A2,TRIM39,DUSP1,HIF1AN,IGFBP3,AGAP3,CAPN2,ALDH3B1,DNAJB6,TXNRD2,RUNX1,TNFAIP8,TPR,PTPMT1,CADPS2,ATF6,NUDT2,CCL3,GLRX,HNRNPK,CIAPIN1,SLC19A3,SHC1,MSRB3,NET1,SAA1,MCRS1,LONP1,AGT,NDUFAF4,RTKN,NQO1,SMAD6,EMD,ZPR1,RCAN1,ADGRG1,CIDEA,PMP22,PIGB,IRF2BP2,CDC34,ALKBH3,DNM1L,NNAT,DPYD,APOB,ITSN1,TGFBR3,HRAS,NCSTN,MIF4GD,SATB2,PEG10,NPTX2,IRS2,TXN,EYA2,CALCRL,NDRG1,RRBP1,THY1,TNK2,FAM129B,LDOC1,TAF9B,S1PR3,CDH2,TIMP4,CCND2,NR1D1,BSG,PTPA,STIP1,SPINT2,MAP2K3,SFRP1,MAPK7,CYR61,IFIT2,ADM,SPTBN1,MME,HIST1H1C,ADAM17,RAB32,TNFSF10,MYH11,VTI1B,UCHL1,FANCE,EFNB2,ID1,ACSM5,GBA,CCL3L3,PSMD14,STIM1,LBP,RASSF5,PCBP2,PTPRT,AMFR,MBOAT7,MYCN,ADRM1,C5AR1,ANGPT1,UBE2M,TYROBP,IMPDH2,MGMT,DEFB1,CYP1B1,YBX2,SUPV3L1,KRT8,TF,S100A9,LIMS1,WAS,SPRY2,LSP1,FCER1G,FKBP4,MS4A2,IGF2BP2,S1PR1,NR5A2,BNIP3L,CBX4,GABARAP,NEDD9,FBN2,PHLDA1,PFKFB1,SPHK2,CXCL12,LIPE,TPM1,SDC4,TAF10,TUBB,CCT8,PARVB,CYP26B1,CEL,TNIP1,G0S2,CRIP1,IP6K1,NEO1,PUF60,KLF2,RTN4R,EIF2AK1,IGFBP6,MIF,AXIN2,DNASE2,SNRK,PKN1,STC1,PPP2R1A,ITGAM,ERCC1,PKD1,SMOX,ASIC1,GNL3,DDAH2,NFIX,VAPA,PKM,ABL1,TNFAIP3,MYLK,SMPD1,HIF1A,IRF3,TNFRSF12A,PDCD4,SOX17,EPHB6,HMOX1,CCL13,PCK2,KCNMA1,CSPG4,C7,CLOCK,KIT,NSMF,NEK7,ARHGEF2,SEMA3B,HCST,CUL9,STK40,PTGER4,PI4KB,PRNP,FAAH,TAF6,CXCR4,AQP11,SCIN,TRIP6,NFKBIZ,NDUFA13,NEK11,PBX3,LPAR1,FASTK,EDNRA,ELK1,RCAN2,DSG2	948	
Cancer, Organismal Injury and Abnormalities	abdominal neoplasm	abdominal neoplasm	1.07E-27	 	0.801	 	1.428	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,ABHD1,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,ATP6AP1,KLF9,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,GOT1,EGR3,MTURN,FBXO22,SLC4A7,PAWR,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,GNG11,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,HCAR1,CEBPD,CDK4,HSD17B11,CTDSPL,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,NTMT1,PPFIBP2,SLC41A2,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,POLR3F,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,RNLS,CANX,N4BP1,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,CSTF2,GUCY1A3,FANCG,NAT10,MMP2,IER3,SCNN1D,RAE1,DOCK1,AQP9,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,UQCRH,CHCHD6,KHDC1,VCAN,SERTAD4,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,KCNJ2,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,ARL17A/ARL17B,STK39,UROS,MAPK8IP2,RIMS4,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,GPS1,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,UBE2I,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,CERCAM,KCND2,DDX11,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,AP2S1,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,ANG,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,KANSL3,THBS3,CORO2B,SF3B3,GPIHBP1,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,PLA2G2A,TRMT12,GBP4,OTUB1,LMO3,SLC48A1,RNF144A,RHBDD2,GALE,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,FZD2,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,--,SRM,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,EIF4EBP3,CTSH,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,ALDH5A1,G3BP2,CNFN,ZNF524,PRDM11,GPM6B,CBR3,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,TTYH3,ABCC3,C11orf68,RBP5,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,PTGDS,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,HIF1AN,MRPS2,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,TPR,COPE,STX6,ABCF1,CRYL1,GTF3A,NAT14,KIFC2,CCL3,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CXCL16,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,PKIA,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,CD68,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,SLC2A6,CMTM8,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,MGMT,DEFB1,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,FBN2,ADSSL1,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,RARRES1,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,CCDC3,ZDHHC7,WARS,CYTIP,TSPAN1,EDNRA,RTN3,RCAN2,ASS1,PAQR7,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,TRIAP1,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,CA4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,RPLP0,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,LDHD,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,HYAL1,TANC2,LRRK2,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,NSUN4,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,PPP1R15A,ARHGEF6,PHF23,CD86,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,IFI27,AHSA2,ASB1,DUSP5,POFUT2,CCL2,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,TP53BP1,BMPER,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,NBAS,ATF3,PKP2,RILPL1,ZNF282,THRA,TRIM35,FOSB,CDC42BPB,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,RAD51D,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,RERGL,PDDC1,ACSF2,NT5C,PFKL,SCO1,FAXDC2,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,PTPN23,VPS28,XXYLT1,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,D2HGDH,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,MAP2K5,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,RPS6KB2,HIST2H2AC,MICALL1,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM132B,SPOCD1,FRMD1,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,HSDL1,ABCC9,CD69,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,GTPBP3,BRINP2,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PHPT1,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,STK24,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,ST6GALNAC2,KANK3,CEP170B,MGP,CAV1,ATF4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,TIMM8B,SMG5,FLOT1,THOP1,RHBDD1,IFNAR2,TRAPPC3,ZNF579,CARD9,IFT122,NRDE2,CTSA,LRRN3,FBXW5,FSCN1,VARS2,TRPC4AP,NCF2,MCEE,GAPDH,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,ZMYND19,B4GALT7,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,IL34,OSBPL11,PIK3R2,CSNK2B,TBC1D10B,FCGR3A/FCGR3B,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,PLA2G4A,SELM,NRXN2,SNUPN,NR4A2,FLNC,FAM129A,GPBAR1,ATP1A2,MBD3,TMEM106C,TAF1C,XAF1,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,ABCG1,C16orf91,HDAC11,GCLM,CAST,CHTF18,CHMP1A,DOK2,GM2A,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,DGCR6L,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,NANOS1,PCSK5,RRBP1,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,SEMA3G,STK19,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,GABARAP,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,SDC4,TAF10,DCAF10,MTCH2,PLEKHG4,CEL,CYP26B1,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,KLF2,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,SRSF3,EFS,C9orf9,ITGAM,ERCC1,SRPK3,PKD1,SLC22A5,PLEKHH3,AK2,RNF165,NFIX,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,KIAA0930,NEK11,EXOC4,DIP2C,LPAR1,JCHAIN,ELK1,DSG2	2395	
Cell Death and Survival	cell death	cell death of tumor cell lines	3.59E-26	Decreased	-3.307	 	-2.553	AXIN1,IL6,CCND3,CSE1L,TSC2,TNFRSF21,ETS1,DDIT4,DVL2,PDLIM7,HLA-DRB4,CTSB,ALCAM,ACACA,TRIAP1,mir-21,FTH1,TUFM,GADD45B,PSMD7,DDIT3,DAPK2,GNA11,ADIPOQ,DDX3X,DIABLO,RABL6,ATN1,UCP2,MECOM,IGF2R,ID3,HNRNPH1,LYN,SOX9,LIG1,SOCS3,FCER1A,DNAJC15,GPC3,CBX5,CTSD,CARD8,CCT5,BIRC3,WDR4,CXCL8,NOX4,TXNRD1,BCL2L1,BAP1,CCDC80,MLKL,VHL,PEBP1,SULF1,IGFBP4,BMP2,HLA-G,EDN1,STUB1,ERBB2,SRC,NLRP3,G6PD,PLAUR,BTK,SPARC,CYB5A,ING1,RPLP0,MSRB2,BMP4,CTGF,GMDS,TYRO3,MIA,AHSA1,MTUS1,RARA,AFAP1,MCL1,SFRP4,BIRC7,CAPN6,CDKN1C,ATG7,CENPB,MT1X,FAHD2A,HBEGF,JUNB,HMGA1,RNASEH2A,ROR1,MAP3K12,DPH2,PDE1B,RTN4,CCT3,NOTCH1,ANG,NRP1,AKAP12,CNN2,FYN,ZFP36,BTG3,LEPR,SIN3B,FKBP1A,CASP4,NAA35,ASNS,SF3B3,EIF4EBP1,KLF9,MCOLN1,LCMT1,JUN,CSF2RA,CD24,ACVR1C,RPS24,WSB1,TRIM28,EGR1,ARHGAP4,CCDC8,AXL,OTUB1,IMMT,DHCR24,BMF,PTGS2,TFF3,PRPF19,CD4,UNC5B,AS3MT,IKBKG,SLC25A6,ETS2,GSK3B,GPC1,RET,HK1,PTPRE,FST,EGR3,HSPA9,PAWR,RASD1,ITPK1,RAP1GAP,PRKCD,IDO1,CLCN7,CRABP2,SFRP2,PA2G4,NGF,PTPRF,CD55,HINT1,MAN2C1,NFKBIA,MARCH8,DKK3,THBS1,SMO,NCL,SULF2,MAPKAPK2,IFRD1,CHEK2,BEX2,PAK4,EPAS1,AVPI1,HYAL1,PRMT1,FAF1,COL1A1,EBF1,MT1F,GBE1,CSTA,RRM2B,CACNA1H,CTSG,SERPINA3,SPI1,ATP2A2,SLC9A1,ODC1,EMG1,EGR2,NUP93,CYBA,MCOLN3,KEAP1,CAV1,ATF4,HIPK2,CERS6,UBE2Q1,PPP1R1B,TNFRSF10B,RPAP3,DCTD,IFNAR2,GPX7,HAX1,HSPA8,CARD9,TNPO2,PPP1R15A,BTG2,ARHGEF6,ATMIN,GAPDH,TFRC,SQSTM1,APOE,NME1,NACC2,OSGIN1,FGF2,HCAR1,GDF15,CEBPD,MTFP1,GRINA,TGM2,CS,CCL2,GADD45A,IL17D,DAB2,TRIM29,ADORA1,HCAR2,RAD21,LIG3,FCER2,MAPKAP1,CUL7,RGS16,TRIB3,GRN,FOS,PLA2G4A,NR4A2,NTRK3,AIMP2,XAF1,ARHGDIA,TP53BP1,BMP6,MAOA,MT2A,SESN2,ATP2B1,RTN1,MBP,PTTG1,HSPA1A/HSPA1B,ACO2,KLF6,OGFOD1,TYMP,RNASE1,STYXL1,HSPA5,AP2A2,MYC,TGFBR2,PADI4,HSPA4,RHOB,HDAC11,GIMAP5,NUPR1,CAST,GULP1,ATF3,BTG1,VEGFC,PPP1R11,THRA,KLF4,SLC3A2,FOSB,GZMH,NOL3,TRIM39,DUSP1,SORCS2,IGFBP3,CAPN2,MDK,PIDD1,ESR1,DPH5,PMEPA1,RUNX1,TNFAIP8,CDC20,SRPX,PTPMT1,ATF6,GLRX,HNRNPK,IRAK1,RAP1GDS1,SHC1,TIMP1,MCRS1,LONP1,ATP13A2,AGT,NDUFAF4,PARVA,RTKN,NQO1,SMAD6,TNFRSF14,NFE2L1,FAIM,RCAN1,CAPNS1,LOC102724788/PRODH,PIGB,IRF2BP2,VAV3,CAT,CDC34,ALKBH3,DNM1L,NNAT,DPYD,APOB,ITSN1,SGK1,TGFBR3,COX8A,ELANE,TRAP1,HRAS,SH3GLB1,CDKN2C,MIF4GD,SATB2,ABCC1,DNAJA3,TXN,NDRG1,STOML2,THY1,RPA1,IER3,TNK2,LDOC1,S1PR3,DOCK1,TIMP4,CCND2,YARS,MAP2K3,SFRP1,MAPK7,CYR61,PHLPP1,ADM,MME,ADAM17,RAB32,EMILIN2,TNFSF10,KAZN,VCAN,UCHL1,FANCE,ID1,MTOR,ACSM5,DAP3,PRKCE,PSMD14,STIM1,RASSF5,COL18A1,PCBP2,PTPRT,PLAT,GSTM1,MYCN,ADRM1,C5AR1,MGMT,NABP1,DEFB1,CYP1B1,LAMP2,TF,S100A9,LIMS1,WAS,SPRY2,LSP1,IGF2BP2,PEA15,BNIP3L,NEDD9,SERPINI1,VPS28,ADRBK1,PFKFB1,SPHK2,CXCL12,CCT8,CEL,G0S2,IP6K1,KPNA2,SIAH2,LTBR,PUF60,KLF2,DDX41,IGFBP6,MIF,SPP1,GPS2,LMO4,ITPR2,LMNA,PKN1,DPP9,PPP2R1A,ITGAM,SMOX,AKR1B1,MAP2K5,LEP,NFIX,ERN1,BCL2L12,PKM,ABL1,TNFAIP3,SMPD1,HIF1A,IRF3,PDCD4,EPHB6,HMOX1,ZMAT3,PCK2,CSPG4,KIT,NEK7,S100A8,SEMA3B,RNF144B,HCST,CUL9,PRNP,CD59,TAF6,CXCR4,SMAD7,SCIN,TRIP6,NFKBIZ,CSF1R,NDUFA13,ENO1,NEK11,PBX3,ELK1,DSG2,MMP9	484	
Cancer, Organismal Injury and Abnormalities	abdominal cancer	abdominal cancer	3.67E-26	 	0.815	 	1.243	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,HLA-DRB4,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,LY6E,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,STRN4,STC2,ANKDD1A,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,AP3M2,ING1,CXCL2,MED24,RER1,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,ABHD1,HOMER3,PPP4C,SGPL1,RNF38,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,PIK3C2B,APTX,DFNA5,ATG7,NAB1,HIGD1B,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,ACAD11,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,ATP6AP1,KLF9,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,GOT1,EGR3,MTURN,FBXO22,SLC4A7,PAWR,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,TMEM98,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,PLLP,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,SLC16A5,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,NACC2,SFXN4,IGSF1,HCAR1,CEBPD,CDK4,HSD17B11,CTDSPL,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,PPFIBP2,SLC41A2,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,GIMAP5,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,CIZ1,VARS,IARS,RNLS,CANX,N4BP1,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,LPAR5,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,ABCC1,CSTF2,GUCY1A3,FANCG,NAT10,MMP2,IER3,SCNN1D,RAE1,DOCK1,AQP9,PIP5K1C,MS4A4A,C11orf80,MS4A7,TRO,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,CHCHD6,KHDC1,VCAN,SERTAD4,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,MFAP4,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,ITPA,DYM,CARM1,ATP6V1B2,CBX7,KCNJ2,SLC6A9,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,FBL,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,ARL17A/ARL17B,STK39,UROS,MAPK8IP2,RIMS4,BAMBI,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,GPS1,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,CERCAM,KCND2,DDX11,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,FAM127A,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,ANG,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,KANSL3,THBS3,CORO2B,SF3B3,GPIHBP1,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,PLA2G2A,TRMT12,GBP4,OTUB1,LMO3,SLC48A1,RNF144A,RHBDD2,GALE,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,FZD2,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,--,SRM,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,GOT2,ATP5I,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,EIF4EBP3,CTSH,IQCC,MTHFD2,HES6,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,BTG2,ATMIN,MUSTN1,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,ALDH5A1,G3BP2,CNFN,ZNF524,PRDM11,GPM6B,CBR3,CYTH3,FOS,HP,TAGLN,ZCWPW1,LRRC75B,SLC22A18,NLE1,TTYH3,ABCC3,C11orf68,RBP5,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,PTGDS,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,HIF1AN,MRPS2,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,TPR,COPE,STX6,ABCF1,CRYL1,GTF3A,NAT14,KIFC2,CCL3,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,TOX2,C10orf35,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CXCL16,CIDEA,PMP22,IRF2BP2,CES4A,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,COQ9,NNAT,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,CD68,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,SLC2A6,CMTM8,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MBOAT7,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,MGMT,DEFB1,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,ALS2CL,DVL3,CBX4,FBN2,ADSSL1,DCAKD,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,RARRES1,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,NFX1,TMEM119,HMOX1,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,CCDC3,ZDHHC7,WARS,CYTIP,TSPAN1,EDNRA,RTN3,RCAN2,ASS1,PAQR7,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,TRIAP1,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,COG5,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,CA4,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,RPLP0,ASPSCR1,SP110,PRG4,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,HMGA1,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,FAM86B1,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,SLC39A3,GALNT13,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,RNF125,ATP2A2,SPI1,MT1E,ODC1,CAAP1,RNASE4,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,NSUN4,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,LHPP,TIMM44,MTSS1,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,CD86,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,DEAF1,IGSF10,PTPRA,NOL7,PLXNA3,FBXO10,SLC4A2,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,IFI27,AHSA2,ASB1,DUSP5,POFUT2,CCL2,DAB2,ASPH,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,LDLR,MYOC,ZFPM2,TPP1,TP53BP1,BMPER,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NOC3L,NCDN,TPPP3,SNX8,ABCA3,RTN1,HSPA1A/HSPA1B,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,NBAS,ATF3,PKP2,RILPL1,ZNF282,THRA,TRIM35,FOSB,CDC42BPB,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,FAM20B,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,PGAP2,GNAI1,ST3GAL6,ZNF16,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,ELANE,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,RAD51D,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,RERGL,PDDC1,ACSF2,NT5C,PFKL,SCO1,FAXDC2,TMEM94,MTOR,WDFY1,TARS2,DHPS,ANXA5,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,HGH1,MCM2,UQCR10,PEA15,ZC2HC1C,ZFP36L2,SCAMP3,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,PTPN23,VPS28,XXYLT1,FNIP2,ARG2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,D2HGDH,LTBR,CLCN3,MYO10,FAM65B,MRPL43,ADRA1B,AGBL5,DDX41,PTX3,MGRN1,NUP155,C8orf46,APLNR,SPP1,GPS2,ZNF408,MACROD1,PCSK7,MARS,MYOF,EIF2S2,RPL9,PANK1,R3HDM4,RRP7A,HSPA13,RGN,LSM7,AKR1B1,MAP2K5,COL7A1,RNPEP,AOC3,CCDC106,SPX,ADAMTS7,B3GALT6,LEP,ERN1,NLGN1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,RPS6KB2,HIST2H2AC,HSD11B2,PSMA3,S100A8,ZNHIT2,MYO16,PRRT3,TMEM132B,SPOCD1,FRMD1,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,SHMT2,MMP9,TOMM40L,RPE,AXIN1,PPP1R14B,BCAT2,ATG9A,PLXNB2,AMHR2,SLC2A5,PTGIS,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,HSDL1,ABCC9,CD69,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,FCER1A,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,WDR4,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,IPO4,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,MKX,KIF21A,AFAP1,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,GAMT,EPB42,ME2,TBL3,TRPT1,C20orf96,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,SLIT2,CCDC8,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,GTPBP3,BRINP2,UAP1L1,CILP,NENF,MAMSTR,LRFN4,PFN1,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,ALDH1A1,BCL7C,ALDH3A2,PHPT1,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,ACSL3,PTPRE,PACSIN3,ICA1,HSPA9,RPUSD1,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,IDO1,RARRES3,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,STK24,MAPKAPK2,KCTD1,NCL,ACADM,CCDC189,RHBDD3,COL5A2,LRRC2,PHLDA3,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,ST6GALNAC2,KANK3,CEP170B,MGP,CAV1,ATF4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,TIMM8B,SMG5,FLOT1,THOP1,RHBDD1,IFNAR2,TRAPPC3,ZNF579,CARD9,IFT122,NRDE2,CTSA,LRRN3,FBXW5,FSCN1,VARS2,TRPC4AP,NCF2,MCEE,GAPDH,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,B4GALT7,ZMYND19,CHDH,FAM102A,PGA5 (includes others),RANGAP1,IL34,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,PLA2G4A,SELM,NRXN2,SNUPN,NR4A2,FLNC,FAM129A,GPBAR1,ATP1A2,MBD3,TMEM106C,TAF1C,XAF1,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,ABCG1,C16orf91,HDAC11,GCLM,CAST,CHTF18,CHMP1A,DOK2,GM2A,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,LIMA1,SOBP,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,TXNRD2,DOCK6,NMT1,ATF6,CADPS2,RPL14,NET1,ENPP2,LONP1,MRPL40,ZNF135,PSAT1,ZNF358,SLC22A12,TUBG1,SMAD6,EMD,GATSL3,ADGRG1,SMG7,ASTN2,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,DGCR6L,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,NANOS1,PCSK5,RRBP1,CPA3,TNK2,FAM129B,LDOC1,TAF9B,TIMP4,CCND2,CDH12,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,STIM1,PSMD14,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,SEMA3G,STK19,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,GABARAP,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,SDC4,TAF10,DCAF10,MTCH2,PLEKHG4,CEL,CYP26B1,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,KLF2,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,FOXC1,LMCD1,EFS,C9orf9,ITGAM,ERCC1,SRPK3,PKD1,PLEKHH3,AK2,RNF165,NFIX,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,EPHB6,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,ARHGAP28,CPA4,KIAA0930,NEK11,EXOC4,DIP2C,LPAR1,JCHAIN,ELK1,DSG2	2372	
Cellular Movement	cell movement	cell movement	4.58E-26	 	1.529	 	-3.082	IL6,PPP1R14B,ATG9A,AJUBA,CSE1L,SMARCB1,TSC2,PLXNB2,AHCY,ETS1,TNFRSF21,COMP,COCH,DDIT4,DVL2,CDH5,CTSB,ALCAM,PLTP,mir-21,FTH1,FHL1,LTBP2,GBP1,DAPK2,GNA11,ADIPOQ,DDX3X,TUBB2B,SYNM,LLGL1,UCP2,CD69,MESP1,ANOS1,PVR,IGF2R,ID3,GPR183,MYO5A,SWAP70,CBS/CBSL,LYN,PROCR,WBP2,SOX9,SOCS3,ADGRA2,RARRES2,HAVCR2,RABEP1,RGCC,TRPM8,FCER1A,GPC3,TUBA1C,VNN2,TEK,RASGRP2,MARCO,KMT5A,ELN,CXCL8,NOX4,ADAMTS1,GNAZ,KANK1,BCL2L1,ADRA2A,TNS1,VHL,SLC11A1,UBE2I,ETV5,PEBP1,SULF1,LOX,IGFBP4,LITAF,SFTPD,ZP3,PLGRKT,BMP2,INPPL1,HDGF,HLA-G,ALDH2,SH3PXD2B,EDN1,STUB1,IGSF8,ERBB2,THBS4,SRC,NLRP3,MMP28,G6PD,PLAUR,SNX27,BTK,RRAS2,SPARC,COL11A1,CXCL2,MAP4K4,CTGF,BMP4,NUDT16L1,TYRO3,MST1,POMC,ACP5,HOMER3,MIA,SGPL1,ITGA3,LGMN,MTUS1,RARA,AFAP1,LYVE1,PIK3C2B,SFRP4,BIRC7,CMKLR1,ATG7,PLEC,HBEGF,JUNB,HMGA1,THBD,ROR1,NINJ1,MAP3K12,PODXL2,RTN4,NOTCH1,NRP1,COL3A1,CNN2,AKAP12,FYN,LEPR,NQO2,HYOU1,SLC1A3,ATAT1,RUVBL1,MEOX2,ASNS,EIF4EBP1,ENAH,LYZ,CES1,JUN,CCL8,CST3,RHOD,CSF2RA,DPCD,CD24,GJB2,PLXNA1,CD209,CD276,PTPRK,EGR1,CSK,ARHGAP4,SLIT2,BRMS1,RELN,AXL,SLC2A8,ANXA3,PTGS2,TM4SF1,TFF3,TNFRSF4,PFN1,LAMTOR2,FAT1,CD36,CD4,MAP1B,UNC5B,RSPO3,IKBKG,CAMK2D,PLA2G5,NAV1,GSK3B,GPC1,C1QBP,RET,FERMT3,FST,GSDMB,TARS,MAPK8IP3,TPSAB1/TPSB2,APBA3,FLCN,SORD,RAP1GAP,PRKCD,SCRIB,CD14,IDO1,SH3BP4,SFRP2,PA2G4,NGF,PTPRF,RAB5A,CD55,NFKBIA,ANGPTL4,THBS1,DKK3,DUSP10,SMO,CFB,CYGB,STK24,NCL,MAPKAPK2,ADRB2,PAK4,AP2M1,EPAS1,TPST2,BHLHE41,PCOLCE2,HYAL1,LRRK2,ARPIN/C15orf38-AP3S2,PRMT1,FAF1,COL1A1,KIF2A,EBF1,MT1F,EPHB3,NUCB2,C6,KDR,NCKAP1L,CPEB1,TNFRSF19,SLIT3,CTSG,SERPINA3,SLC9A1,SPI1,EGR2,CTSH,KEAP1,MYADM,LUM,MGP,ST6GALNAC2,CAV1,DLG4,EBF2,HES6,HIPK2,SELE,DPT,PODN,MTSS1,TMEM201,CARMIL1,ANO6,FLOT1,TFPI2,HAX1,CARD9,FSCN1,PPP1R15A,BTG2,NCF2,ARHGEF6,GAPDH,CD86,ITGA1,SQSTM1,PTPRA,APOE,NME1,SLC4A2,FGF2,PHLDA2,OSGIN1,SEMA6A,ACKR2,GDF15,CEBPD,CDK4,G6PC3,GRINA,TGM2,GADD45A,CHDH,CCL2,SOS1,IL34,DAB2,CSNK2B,PIK3R2,ASPH,ADORA1,HCAR2,POMGNT2,FCGR3A/FCGR3B,HEY1,P4HA2,FCER2,CCR1,S100A1,ZNF580,TJP1,RGS16,ST3GAL3,GRN,FOS,PLA2G4A,HP,LY96,MYOC,NR4A2,LDLR,NTRK3,FLNC,SERPINH1,ARHGDIA,MAP3K8,SEMA3C,BMP6,ST3GAL4,QPCT,USP5,PTTG1,ITGB1BP1,MBP,HSPA1A/HSPA1B,KLF6,ACO2,TYMP,HSPA5,MYC,TGFBR2,ADGRF5,RHOB,MAP2K2,TMEM8B,CXCL14,STAB1,PDCD6,CAST,ATF3,PKP2,IER2,DOK2,PEX7,LAMA2,VEGFC,CAPG,THRA,PTGDS,ORMDL3,KLF4,SLC3A2,FOSB,SDCBP,ORM1,MATN2,GIPC1,DUSP1,ARHGEF16,LIMA1,IGFBP3,CAPN2,DNAJB6,MDK,ESR1,C2,S100P,TNFAIP8,RUNX1,TPR,STX6,CADPS2,CCL3,GLRX,HNRNPK,ETV6,SHC1,AHNAK,NET1,TIMP1,MCAM,SAA1,MKL2,RNH1,ENPP2,AGT,VCAM1,PARVA,SLC12A2,NQO1,ST3GAL6,GNAI1,EMD,TNFRSF14,SH3PXD2A,SERPINE2,CXCL16,ADGRG1,RCAN1,PMP22,CAPNS1,KIF5B,VAV3,CAT,NREP,CAMK1,APOB,SGK1,DNAJB4,TGFBR3,ELANE,HRAS,CDKN2C,HOXA9,NEU1,SATB2,DGCR6L,ABR,ABCC1,NPTX2,VEGFD,DNAJA3,IRS2,TXN,HEY2,EYA2,WNT5B,MATK,ARHGEF4,CALCRL,NDRG1,GUCY1A3,THY1,MMP2,TNK2,S1PR3,DOCK1,CDH2,AQP9,NR1D1,BSG,YARS,PIP5K1C,MS4A4A,IL10RA,ALDOA,RSU1,MAP2K3,RAMP3,LRP8,MAPK7,SFRP1,CYR61,IFIT2,PDGFD,ADM,MME,ADAM17,RALA,EMILIN2,WASF3,TNFSF10,MYH11,DCLK1,VCAN,IDH1,EFNB2,ID1,TRIB1,MTOR,GBA,CCL3L1,CCL3L3,SRGAP1,ANXA5,CMTM8,STARD13,RHOU,SOCS2,PRKCE,ACSL4,STIM1,RASSF5,LBP,LPP,COL18A1,SARS,NCKIPSD,PLAT,IL11RA,MBOAT7,SOX7,VPS18,C5AR1,ANGPT1,TYROBP,EPB41L4B,HDC,DPAGT1,DEFB1,CYP1B1,F11R,GLIPR2,KRT8,MCM2,S100A9,WAS,LIMS1,CNN1,SPRY2,CHFR,PELI1,LSP1,FCER1G,S1PR1,FKBP4,TAZ,NEDD9,RUFY3,FZD7,RGS1,PHLDA1,ADRBK1,PTPN23,VPS28,SPHK2,CXCL12,HARS,LIPE,TPM1,SDC4,TUBB,MTCH2,NARS,CYP26B1,ESAM,OSR1,PRND,NEO1,KPNA2,SIAH2,LTBR,FBXO45,CLCN3,FAM65B,KLF2,MYO10,PTX3,CSF3R,IGFBP6,MIF,APLNR,SPP1,LMO4,LMNA,FOXC1,PKN1,LMCD1,STC1,EFS,ITGAM,CORO1B,PKD1,ASIC1,CCL18,AKR1B1,MAP2K5,COL7A1,AOC3,GDI1,ADAMTS7,LEP,NFIX,FLRT2,PKM,ABL1,RARRES1,TNFAIP3,SMPD1,MYLK,GPR34,IRF3,HIF1A,RAMP2,PDCD4,TNFRSF12A,HMOX1,CCL13,CSPG4,FLNA,KCNMA1,KIT,S100A8,SEMA3B,PTGER4,PRNP,NDUFAF3,FAAH,CD59,CXCR4,SMAD7,F13A1,TRIP6,NFKBIZ,CSF1R,ENO1,WARS,CYTIP,LPAR1,EDNRA,NDNF,ELK1,DSG2,P2RX7,MMP9	636	
Organismal Survival	organismal death	organismal death	4.93E-26	Decreased	-8.189	bias	3.017	PCLO,SLC6A9,KCNJ2,AXIN1,ASS1,VAC14,C1QA,IL6,POR,IDUA,CCND3,ATG9A,CSE1L,PPRC1,SMARCB1,TSC2,PLXNB2,ETS1,FBL,RBM38,HEYL,SLX4,SURF1,DVL2,CDH5,NPR3,CTSB,ACACA,ATOX1,mir-21,FTH1,LTBP2,GNA11,ADIPOQ,HEXA,TIPARP,LLGL1,LY6E,GNG5,ABCC9,ATN1,UCP2,MECOM,ZNF521,MESP1,CDO1,PVR,TK2,IGF2R,ID3,KIF7,CBS/CBSL,LYN,PROCR,SOX9,LIG1,SOCS3,ADGRA2,AKR1C3,CA4,HAVCR2,ZFPM1,NARFL,INTS1,GPC3,CTSD,EEF1E1,MTMR2,BIRC3,TEK,MARCO,KMT5A,ELN,CXCL8,STXBP1,TJP2,H19,ADAMTS1,UROS,MAPK8IP2,FIG4,STX1A,ERCC2,EIF4E2,TXNRD1,AES,BCL2L1,H3F3A/H3F3B,ADRA2A,BAP1,COMMD1,NAGLU,VHL,UBE2I,SUN1,SULF1,LOX,NELFB,BMP2,ADH1C,CLUAP1,INPPL1,EMX2,HLA-G,DHCR7,EDN1,F8,STUB1,ERBB2,SRC,EPN1,NLRP3,COL6A2,G6PD,CSRNP1,PLAUR,SNX27,SERTAD1,KIF3B,ACADVL,FECH,COL11A1,ING1,CXCL2,EFEMP2,MED24,MAP4K4,COX15,DDX11,CTGF,BMP4,CA12,POMC,EIF6,PPP4C,GSS,RAD23A,NR4A3,SGPL1,ITGA3,DMRT2,PLS3,MTUS1,RARA,HMBS,HADHA,RFNG,MCL1,ATG7,NAB1,SV2B,ZC3HC1,PRAG1,CENPB,DKC1,PLEC,HBEGF,CREB5,ROR1,THBD,NINJ1,SH3GL1,MAP3K12,GAMT,RTN4,ALAS2,CAPRIN1,NOTCH1,NRP1,B9D1,COL3A1,AKAP12,FYN,ZFP36,LEPR,PPP1R3C,SIN3B,HYOU1,SLC1A3,FKBP1A,MEOX2,ABCA5,ATP6AP1,H2AFZ,ENAH,MAFG,CELF1,MCOLN1,KLF9,LYZ,KAT2B,JUN,CST3,CD24,HGS,GJB2,SLC25A13,ABHD5,BLMH,WDR55,COL12A1,TRIM28,CSK,CSRNP2,SLIT2,ACLY,COPS3,SRXN1,PLA2G2A,SLC2A8,LMO3,SBF1,BMF,PTGS2,ARID4A,MAMSTR,PFN1,PRPF19,LAMTOR2,FAT1,CD36,CD4,MAP1B,MNS1,CLIP3,METAP2,RSPO3,IKBKG,ALDH1A1,ETS2,PLA2G5,PCYT2,AMPH,GSK3B,C1QBP,RET,FERMT3,TTYH1,FST,ICA1,EGR3,FZD9,MAPK8IP3,INHBB,APBA3,FLCN,PRKCD,N6AMT1,SCRIB,IDO1,CD14,CLCN7,RCE1,CRABP2,--,SFRP2,NGF,PTPRF,RAB5A,CD55,NFKBIA,ANGPTL4,THBS1,HSPE1,CFB,MAPKAPK2,SULF2,HMGCL,ACADM,CHEK2,ADRB2,RHBDD3,COL5A2,PAK4,AP2M1,EPAS1,ATP2C1,PERP,VSIG4,LRRK2,PRMT1,COL1A1,KIF2A,EBF1,EPHB3,GBE1,GAP43,KDR,RRM2B,CA5B,SLC35C1,SLC9A1,ATP2A2,SPI1,GATAD2A,EGR2,KEAP1,KIF1A,LUM,MTHFD2,MGP,CAV1,ATF4,NABP2,HIPK2,KAT2A,UNG,SELE,STK36,MTSS1,UBE2Q1,C1GALT1C1,IFNAR2,GPX7,HAX1,NRBP1,PYGO2,CARD9,MN1,IFT122,CTSA,FSCN1,PPP1R15A,ATMIN,TFRC,B3GAT3,SQSTM1,BYSL,DEAF1,APOE,SLC4A2,FGF2,CFC1/CFC1B,HS2ST1,GDF15,CEBPD,CDK4,COPS8,G6PC3,TGM2,GADD45GIP1,GADD45A,SOS1,DAB2,ASPH,CSNK2B,ADORA1,POMGNT2,CYP51A1,ALDH5A1,LIG3,HEY1,CCR1,TSTA3,SPRY1,CUL7,DGAT2,SLCO2A1,GPM6B,AGL,GRN,FOS,HP,LY96,LDLR,NRXN2,ZFPM2,NR4A2,NTRK3,FLNC,SERPINH1,ATP1A2,MBD3,TPP1,ARHGDIA,MAP3K8,TP53BP1,NLE1,BMPER,MSRA,BMP6,SGCD,ADRA1A,ABCB6,NOC3L,ATP2B1,PTTG1,ITGB1BP1,ABCA3,PARP2,KLF6,TYMP,HSPA5,BIN1,CEBPG,GPNMB,MYC,TGFBR2,PADI4,GPX3,ADGRF5,KCNAB1,GPR4,CXCL14,STAB1,GCLM,CHTF18,CAST,NEDD4L,KCNJ8,PFKFB3,ATF3,PKP2,LAMA2,UNC13B,VEGFC,THRA,C9orf114,ANO1,DCHS1,KLF4,SLC3A2,DUSP1,ALDH1A2,IGFBP3,CAPN2,FZD5,H1F0,DNAJB6,MEGF8,ESR1,TXNRD2,RUNX1,CDC20,PTPMT1,CADPS2,ATF6,HNRNPK,VPS4A,ETV6,SLC2A3,IRAK1,CIAPIN1,SHC1,SLC19A3,TIMP1,MKL2,ENPP2,LRPPRC,PSMG1,AGT,GJA4,SLC20A1,VCAM1,DHRS3,NUSAP1,SLC12A2,TUBG1,NQO1,GNAI1,CANX,BSCL2,NFE2L1,ZPR1,FAIM,SH3PXD2A,RCAN1,CAPNS1,KIF5B,VAV3,RPS6KA4,ALKBH3,DNM1L,PNPLA6,DPYD,MIB2,APOB,ITSN1,DNAJB4,TGFBR3,MAF,ELANE,HRAS,CDKN2C,NCSTN,APRT,HOXA9,SATB2,PEG10,ABR,ABCC1,SPTLC2,ANK2,DNAJA3,IRS2,TXN,HEY2,WNT5B,CALCRL,NDRG1,GUCY1A3,PCSK5,CPA3,MMP2,RAD51D,PLOD1,CRABP1,RAE1,S1PR3,DOCK1,CDH2,SRGAP3,TIMP4,ASGR1,CCND2,CD68,VKORC1,BSG,PIP5K1C,STIP1,SPINT2,TRO,RPL6,MAP2K3,LRP8,MAPK7,BACE2,SFRP1,CYR61,IFIT2,ITGA7,ADM,MME,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,ADAM17,RALA,TCEA1,TNFSF10,MYH11,TENM3,VTI1B,VCAN,IDH1,COL5A1,EFNB2,ID1,TADA3,MTOR,GBA,CCL3L3,ALDH1A3,PTS,STARD13,SLC19A1,STIM1,PRPF31,PI4KA,NAPB,PLOD3,PLAT,IL11RA,MBOAT7,CYP11A1,MYCN,SOX7,GSTM1,C5AR1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,DEFB1,POLD1,POMGNT1,LAMP2,SUPV3L1,KRT8,CLDN5,TF,MCM2,S100A9,LIMS1,SLC25A19,SPRY2,CHFR,PELI1,FCER1G,PEA15,S1PR1,FKBP4,NR5A2,BNIP3L,DVL3,CBX4,GABARAP,ZFP36L2,VPS52,FBN2,ADRBK1,CXCL12,SDC4,TAF10,CYP26B1,TNIP1,ITGA11,BRSK1,OSR1,SLC7A5,SIAH2,CCDC86,LTBR,FBXO45,CLCN3,KLF2,ACTA1,ADRA1B,PTX3,EIF2AK1,MIF,APLNR,SPP1,DNASE2,SGCG,LMO4,ITPR2,LMNA,PANK1,SRSF3,ARF5,ITGAM,ERCC1,PKD1,CSAD,SNX1,RGN,GNL3,EXTL3,TMOD1,MAP2K5,COL7A1,DRAP1,LEP,NFIX,EPB41L3,NLGN1,ERN1,FLRT2,PKM,ABL1,RBBP8,SLC7A1,TNFAIP3,SMPD1,IRF3,HIF1A,RAMP2,CDKN2B,PDCD4,SOX17,HMOX1,AEBP1,FLNA,KCNMA1,RPS6KB2,KIT,HSD11B2,S100A8,NEK7,HCST,CUL9,ALPL,STK40,CTDNEP1,PTGER4,PRNP,COX17,CD59,CXCR4,AQP11,SMAD7,F13A1,NFKBIZ,CSF1R,NDUFA13,ITPA,PBX3,LPAR1,LRP1B,EDNRA,DSG2,CARM1,MMP9,SHMT2	696	
Organismal Survival	morbidity or mortality	morbidity or mortality	7.62E-26	Decreased	-8.066	bias	2.889	PCLO,SLC6A9,KCNJ2,AXIN1,ASS1,VAC14,C1QA,IL6,POR,IDUA,CCND3,ATG9A,CSE1L,PPRC1,SMARCB1,TSC2,PLXNB2,ETS1,FBL,RBM38,HEYL,SLX4,SURF1,DVL2,CDH5,NPR3,CTSB,ACACA,ATOX1,mir-21,FTH1,LTBP2,GNA11,ADIPOQ,HEXA,TIPARP,LLGL1,LY6E,GNG5,ABCC9,ATN1,UCP2,MECOM,ZNF521,MESP1,CDO1,PVR,TK2,IGF2R,ID3,KIF7,CBS/CBSL,LYN,PROCR,SOX9,LIG1,SOCS3,ADGRA2,AKR1C3,CA4,HAVCR2,ZFPM1,NARFL,INTS1,GPC3,CTSD,EEF1E1,MTMR2,BIRC3,TEK,MARCO,KMT5A,ELN,CXCL8,STXBP1,TJP2,H19,ADAMTS1,UROS,MAPK8IP2,FIG4,GNAZ,STX1A,ERCC2,EIF4E2,TXNRD1,AES,BCL2L1,H3F3A/H3F3B,ADRA2A,BAP1,COMMD1,NAGLU,VHL,UBE2I,SUN1,SULF1,LOX,NELFB,BMP2,ADH1C,CLUAP1,INPPL1,EMX2,HLA-G,DHCR7,EDN1,F8,STUB1,ERBB2,SRC,EPN1,NLRP3,COL6A2,G6PD,CSRNP1,PLAUR,SNX27,SERTAD1,KIF3B,ACADVL,FECH,COL11A1,ING1,CXCL2,EFEMP2,MED24,MAP4K4,COX15,DDX11,CTGF,BMP4,CA12,POMC,EIF6,PPP4C,GSS,RAD23A,NR4A3,SGPL1,ITGA3,DMRT2,PLS3,MTUS1,RARA,HMBS,HADHA,RFNG,MCL1,ATG7,NAB1,SV2B,ZC3HC1,PRAG1,CENPB,DKC1,PLEC,HBEGF,CREB5,ROR1,THBD,NINJ1,SH3GL1,MAP3K12,GAMT,RTN4,ALAS2,CAPRIN1,NOTCH1,NRP1,B9D1,COL3A1,AKAP12,FYN,ZFP36,LEPR,PPP1R3C,SIN3B,HYOU1,SLC1A3,FKBP1A,CASP4,MEOX2,ABCA5,ATP6AP1,H2AFZ,ENAH,MAFG,CELF1,MCOLN1,KLF9,LYZ,KAT2B,JUN,CST3,CD24,HGS,GJB2,SLC25A13,ABHD5,BLMH,WDR55,COL12A1,TRIM28,CSK,CSRNP2,SLIT2,ACLY,COPS3,SRXN1,PLA2G2A,SLC2A8,LMO3,SBF1,BMF,PTGS2,ARID4A,MAMSTR,PFN1,PRPF19,LAMTOR2,FAT1,CD36,CD4,MAP1B,MNS1,CLIP3,METAP2,RSPO3,IKBKG,ALDH1A1,ETS2,PLA2G5,PCYT2,AMPH,GSK3B,C1QBP,RET,FERMT3,TTYH1,FST,ICA1,EGR3,FZD9,MAPK8IP3,INHBB,APBA3,FLCN,PRKCD,N6AMT1,SCRIB,IDO1,CD14,CLCN7,RCE1,CRABP2,--,SFRP2,NGF,PTPRF,RAB5A,CD55,NFKBIA,ANGPTL4,THBS1,HSPE1,CFB,MAPKAPK2,SULF2,HMGCL,ACADM,CHEK2,ADRB2,RHBDD3,COL5A2,PAK4,AP2M1,EPAS1,ATP2C1,PERP,VSIG4,LRRK2,PRMT1,COL1A1,KIF2A,EBF1,EPHB3,GBE1,GAP43,KDR,RRM2B,CA5B,CTSG,SLC35C1,SLC9A1,ATP2A2,SPI1,GATAD2A,EGR2,KEAP1,KIF1A,LUM,MTHFD2,MGP,CAV1,ATF4,NABP2,HIPK2,KAT2A,UNG,SELE,STK36,MTSS1,UBE2Q1,C1GALT1C1,IFNAR2,GPX7,HAX1,NRBP1,PYGO2,CARD9,MN1,IFT122,CTSA,FSCN1,PPP1R15A,ATMIN,TFRC,B3GAT3,SQSTM1,BYSL,DEAF1,APOE,SLC4A2,FGF2,CFC1/CFC1B,HS2ST1,GDF15,CEBPD,CDK4,COPS8,G6PC3,TGM2,GADD45GIP1,GADD45A,SOS1,DAB2,ASPH,CSNK2B,ADORA1,POMGNT2,CYP51A1,ALDH5A1,LIG3,HEY1,CCR1,TSTA3,SPRY1,CUL7,DGAT2,SLCO2A1,GPM6B,AGL,GRN,FOS,HP,LY96,LDLR,NRXN2,ZFPM2,NR4A2,NTRK3,FLNC,SERPINH1,ATP1A2,MBD3,TPP1,ARHGDIA,MAP3K8,TP53BP1,NLE1,BMPER,MSRA,BMP6,SGCD,ADRA1A,ABCB6,NOC3L,ATP2B1,PTTG1,ITGB1BP1,ABCA3,PARP2,KLF6,TYMP,HSPA5,BIN1,CEBPG,GPNMB,MYC,TGFBR2,PADI4,GPX3,ADGRF5,KCNAB1,GPR4,CXCL14,STAB1,GCLM,CAST,CHTF18,NEDD4L,KCNJ8,PFKFB3,ATF3,PKP2,LAMA2,UNC13B,VEGFC,THRA,C9orf114,ANO1,DCHS1,KLF4,SLC3A2,DUSP1,ALDH1A2,IGFBP3,CAPN2,FZD5,H1F0,DNAJB6,MEGF8,ESR1,TXNRD2,RUNX1,CDC20,PTPMT1,ATF6,CADPS2,HNRNPK,VPS4A,ETV6,SLC2A3,IRAK1,CIAPIN1,SHC1,SLC19A3,TIMP1,MKL2,ENPP2,LRPPRC,PSMG1,AGT,GJA4,SLC20A1,VCAM1,DHRS3,NUSAP1,SLC12A2,TUBG1,NQO1,GNAI1,CANX,BSCL2,TNFRSF14,NFE2L1,ZPR1,FAIM,SH3PXD2A,RCAN1,CAPNS1,KIF5B,VAV3,RPS6KA4,ALKBH3,DNM1L,PNPLA6,DPYD,MIB2,APOB,ITSN1,DNAJB4,TGFBR3,MAF,ELANE,HRAS,CDKN2C,NCSTN,APRT,HOXA9,SATB2,PEG10,ABR,ABCC1,SPTLC2,ANK2,DNAJA3,IRS2,TXN,HEY2,WNT5B,CALCRL,NDRG1,GUCY1A3,PCSK5,CPA3,MMP2,RAD51D,PLOD1,CRABP1,RAE1,S1PR3,DOCK1,CDH2,SRGAP3,TIMP4,ASGR1,CCND2,CD68,VKORC1,BSG,PIP5K1C,STIP1,SPINT2,TRO,RPL6,MAP2K3,LRP8,MAPK7,BACE2,SFRP1,CYR61,IFIT2,ITGA7,ADM,MME,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,ADAM17,RALA,TCEA1,TNFSF10,MYH11,TENM3,VTI1B,VCAN,IDH1,COL5A1,EFNB2,ID1,TADA3,MTOR,GBA,CCL3L3,ALDH1A3,PTS,STARD13,SLC19A1,STIM1,RASSF5,PRPF31,PI4KA,NAPB,PLOD3,PLAT,IL11RA,MBOAT7,CYP11A1,MYCN,SOX7,GSTM1,C5AR1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,DEFB1,POLD1,POMGNT1,LAMP2,SUPV3L1,KRT8,CLDN5,TF,MCM2,S100A9,LIMS1,SLC25A19,SPRY2,CHFR,PELI1,FCER1G,PEA15,S1PR1,FKBP4,NR5A2,BNIP3L,DVL3,CBX4,GABARAP,ZFP36L2,VPS52,FBN2,ADRBK1,CXCL12,SDC4,TAF10,CYP26B1,TNIP1,ITGA11,BRSK1,OSR1,SLC7A5,SIAH2,CCDC86,LTBR,FBXO45,CLCN3,KLF2,ACTA1,ADRA1B,PTX3,EIF2AK1,MIF,APLNR,SPP1,DNASE2,SGCG,LMO4,ITPR2,LMNA,PANK1,SRSF3,ARF5,ITGAM,ERCC1,PKD1,CSAD,SNX1,RGN,GNL3,EXTL3,TMOD1,MAP2K5,COL7A1,DRAP1,LEP,NFIX,EPB41L3,ERN1,NLGN1,FLRT2,ANTXR1,PKM,ABL1,RBBP8,SLC7A1,TNFAIP3,SMPD1,IRF3,HIF1A,RAMP2,CDKN2B,PDCD4,SOX17,HMOX1,AEBP1,FLNA,KCNMA1,RPS6KB2,KIT,HSD11B2,S100A8,NEK7,HCST,CUL9,ALPL,STK40,CTDNEP1,PTGER4,PRNP,COX17,CD59,CXCR4,AQP11,SMAD7,F13A1,NFKBIZ,CSF1R,NDUFA13,ITPA,PBX3,LPAR1,JCHAIN,LRP1B,EDNRA,DSG2,CARM1,SHMT2,MMP9	703	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive organ tumor	digestive organ tumor	3.84E-25	 	0.336	 	1.097	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,NARFL,STRN4,STC2,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,RER1,CTGF,GMDS,SNTA1,CA12,ABHD1,HOMER3,RNF38,SGPL1,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,CTNS,PIK3C2B,APTX,ATG7,NAB1,HIGD1B,PLEC,HBEGF,CNOT10,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,GOT1,EGR3,MTURN,SLC4A7,PAWR,ATP10A,ALAD,ZMYND15,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,TMEM98,C4orf32,MAD2L2,RUNDC3B,CARMIL1,LAMC3,OSGIN2,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,SFXN4,IGSF1,HCAR1,CEBPD,CDK4,HSD17B11,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,TMEM8A,NTMT1,PPFIBP2,SLC41A2,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,RPAP1,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,ABR,ZHX2,ABCC1,CSTF2,GUCY1A3,FANCG,NAT10,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,SERTAD4,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,FLNA,RNF144B,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,F13A1,ZBTB42,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,DYM,CARM1,ATP6V1B2,CBX7,KCNJ2,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,H6PD,FIG4,RAB34,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,PC,BMP2,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PREB,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,PALMD,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,ALAS2,CAPRIN1,ANG,AKAP12,MAP7,SQLE,FYN,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,THBS3,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,PLA2G2A,GBP4,OTUB1,SLC48A1,RHBDD2,GALE,ANXA3,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,FZD2,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,--,SRM,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,ATP5I,CHEK2,ZFP42,EMILIN1,BEX2,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,EIF4EBP3,CTSH,IQCC,HES6,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,ATMIN,MUSTN1,PPDPF,OSGIN1,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,GALM,CYTH3,FOS,HP,TAGLN,ZCWPW1,SLC22A18,NLE1,TTYH3,ABCC3,C11orf68,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,TPR,STX6,ABCF1,CRYL1,KIFC2,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,C10orf35,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,IRF2BP2,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,DNM1L,NREP,COQ9,PARP6,CADM3,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,CD68,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,VTI1B,IDH1,FANCE,UCHL1,EFNB2,ID1,SLC2A6,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,DVL3,CBX4,FBN2,ADSSL1,DCAKD,SPHK2,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,TMEM119,NFX1,HMOX1,C1orf54,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,PRNP,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,ZDHHC7,CCDC3,WARS,CYTIP,EDNRA,RTN3,ASS1,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,TRIAP1,ATG101,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,WDR86,NDST2,CYP4F11,CA4,TRPM8,TMEM169,MYL6B,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,RPLP0,ASPSCR1,SP110,PRG4,MTUS1,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,LDHD,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,IRX5,APEH,FAHD2B,CCDC136,MS4A14,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,GALNT13,SLC39A3,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,CCDC85A,C16orf58,NCAPH2,ANO2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,CSTA,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,SPI1,ATP2A2,MT1E,ODC1,RNASE4,CAAP1,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,TIMM44,LHPP,MTSS1,MFAP5,RAB3IL1,REEP6,DCTD,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,PPP1R15A,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,IGSF10,PTPRA,DEAF1,NOL7,FBXO10,SLC4A2,PLXNA3,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,AHSA2,ASB1,DUSP5,POFUT2,CCL2,DAB2,ASPH,ADORA1,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,LDLR,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NCDN,NOC3L,TPPP3,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,NBAS,ATF3,PKP2,RILPL1,ZNF282,THRA,TRIM35,CDC42BPB,TLN2,MATN2,PLEKHF1,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,FAM20B,SLC1A4,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,PGAP2,ST3GAL6,GNAI1,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PDDC1,ACSF2,NT5C,PFKL,SCO1,FAXDC2,TMEM94,MTOR,WDFY1,TARS2,DHPS,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,HGH1,MCM2,UQCR10,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,XXYLT1,FNIP2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,GPS2,ZNF408,MACROD1,MYOF,MARS,RPL9,PANK1,R3HDM4,RRP7A,HSPA13,RGN,ACOT4,LSM7,AKR1B1,MAP2K5,RNPEP,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,ERN1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,HSD11B2,S100A8,ZNHIT2,MYO16,PRRT3,TMEM132B,SPOCD1,FRMD1,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,TOMM40L,RPE,AXIN1,PPP1R14B,ATG9A,BCAT2,PLXNB2,AMHR2,PTGIS,SLC2A5,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,HSDL1,ABCC9,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,ANKMY1,FCER1A,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,DNASE1L3,PLGRKT,INPPL1,PHLDB2,COL6A6,HLA-G,SNX16,ESPNL,GTPBP2,SRC,IPO4,POLR3B,PRUNE2,GYG2,SLC15A4,MKX,KIF21A,AFAP1,CMKLR1,RNASEH2A,NGRN,CLEC4F,GAMT,EPB42,ME2,TBL3,TRPT1,C20orf96,ENAH,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,CCDC8,SLIT2,TMEM42,GABRE,DCAF13,RBM42,GTPBP3,BRINP2,UAP1L1,CILP,NENF,MAMSTR,LRFN4,TNFRSF4,PFN1,C8orf82,FAT1,TCEB2,WDR5,GSPT1,BCL7C,ALDH3A2,PHPT1,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,RARRES3,IDO1,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,STK24,KCTD1,NCL,MAPKAPK2,CCDC189,RHBDD3,COL5A2,LRRC2,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,ST6GALNAC2,KANK3,CEP170B,MGP,CAV1,ATF4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,TIMM8B,SMG5,FLOT1,THOP1,RHBDD1,IFNAR2,TRAPPC3,ZNF579,CARD9,IFT122,NRDE2,CTSA,LRRN3,FBXW5,FSCN1,VARS2,TRPC4AP,NCF2,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,B4GALT7,ZMYND19,GADD45A,CHDH,FAM102A,PGA5 (includes others),RANGAP1,IL34,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,PLA2G4A,SELM,NRXN2,SNUPN,NR4A2,FLNC,FAM129A,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,ABCG1,C16orf91,HDAC11,GCLM,CHTF18,CAST,CHMP1A,DOK2,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,TXNRD2,DOCK6,NMT1,CADPS2,ATF6,NET1,ENPP2,MRPL40,LONP1,ZNF135,PSAT1,ZNF358,SLC22A12,TUBG1,SMAD6,ADGRG1,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,DGCR6L,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,LBP,PRPF31,AMFR,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,SDC4,TAF10,DCAF10,PLEKHG4,CEL,CYP26B1,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,LMCD1,EFS,C9orf9,ITGAM,ERCC1,PKD1,SLC22A5,PLEKHH3,AK2,RNF165,NFIX,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,EXOC4,DIP2C,LPAR1,JCHAIN,ELK1,DSG2	2221	
Cell Death and Survival	apoptosis	apoptosis	5.16E-25	Decreased	-3.017	 	-1.137	AXIN1,ASS1,C1QA,IL6,POR,CCND3,EIF3B,CSE1L,SMARCB1,TSC2,ETS1,PTGIS,TNFRSF21,FBL,HEYL,COMP,DDIT4,SLX4,SURF1,DVL2,PDLIM7,CDH5,CTSB,ALCAM,ACACA,TRIAP1,BRE,mir-21,FTH1,EPHX1,GADD45B,DDIT3,DAPK2,GNA11,ADIPOQ,MCTS1,FNTA,DDX3X,DIABLO,RABL6,GNG5,ATN1,UCP2,MECOM,APBB3,CD69,IGF2R,ID3,CSTB,GPAM,SWAP70,HNRNPH1,CBS/CBSL,LYN,PROCR,SOX9,LIG1,SOCS3,CA4,HAVCR2,FCER1A,DNAJC15,INTS1,GPC3,CBX5,CTSD,CARD8,EEF1E1,NSMAF,BIRC3,TEK,KMT5A,CXCL8,NOX4,STXBP1,TJP2,ADAMTS1,STX1A,ERCC2,TXNRD1,AES,BCL2L1,BAP1,SLC25A10,CCDC80,VHL,UBE2I,SUN1,ETV5,PEBP1,SULF1,IGFBP4,SFTPD,DNASE1L3,NELFB,BMP2,INPPL1,EMX2,HDGF,HLA-G,ALDH2,EDN1,STUB1,ERBB2,SRC,NLRP3,G6PD,CSRNP1,PLAUR,MT1A,RBCK1,BTK,RRAS2,SPARC,TSC22D1,ING1,CYB5A,CXCL2,MAP4K4,RPLP0,KCND2,EIF3C,DDX11,GFPT1,CTGF,MSRB2,BMP4,GMDS,TYRO3,MST1,POMC,EIF6,MIA,NR4A3,SGPL1,SP110,ITGA3,AHSA1,LGMN,MTUS1,RARA,MCL1,SFRP4,BIRC7,CAPN6,CDKN1C,ATG7,ZC3HC1,CENPB,HBEGF,GRK5,JUNB,HMGA1,MNDA,ROR1,NLRX1,THBD,NINJ1,DPH2,MAP3K12,PDE1B,RTN4,CAPRIN1,ANG,NOTCH1,NRP1,CNN2,AKAP12,FYN,ZFP36,GSTM5,LEPR,NQO2,SIN3B,HYOU1,SLC1A3,FKBP1A,ATAT1,NAA35,CASP4,MEOX2,ASNS,EIF4EBP1,MCOLN1,KLF9,LCMT1,KAT2B,JUN,CST3,CSF2RA,TUB,CD24,ACVR1C,RPS24,PRPH,WSB1,EGR1,TRIM28,CSK,ARHGAP4,SLIT2,CCDC8,BRMS1,ACLY,AXL,SRXN1,OTUB1,DHCR24,IMMT,BMF,PTGS2,ATAD3A,TFF3,PFN1,TNFRSF4,PRPF19,LAMTOR2,CD36,CD4,MAP1B,UNC5B,CLIP3,LHCGR,IKBKG,CAMK2D,ALDH1A1,SLC25A6,PLCE1,ETS2,PLA2G5,GSK3B,C1QBP,RET,FZD2,HK1,PTPRE,FST,EGR3,GNG2,HSPA9,SLC4A7,PAWR,RASD1,TPSAB1/TPSB2,FLCN,ITPK1,PRKCD,SCRIB,IDO1,CD14,CRABP2,UTP11,SFRP2,PA2G4,HIGD1A,ATF5,NGF,PTPRF,HINT1,MAN2C1,CD55,NFKBIA,ANGPTL4,THBS1,DKK3,MARCH8,DUSP10,HSPE1,USP47,SMO,STK24,MAPKAPK2,SULF2,NCL,FAM162A,CHEK2,ADRB2,BEX2,PAK4,EPAS1,BHLHE41,ATP2C1,P2RX4,PHLDA3,HYAL1,PERP,LRRK2,PRMT1,COL1A1,FAF1,EBF1,MT1F,C6,KDR,CPEB1,NCKAP1L,TNFRSF19,CSTA,RRM2B,CTSG,SERPINA3,SLC9A1,SPI1,ODC1,EGR2,GATAD2A,CTSH,CYBA,KEAP1,MCOLN3,LUM,MGP,CAV1,ATF4,DLG4,HIPK2,KAT2A,ALDH3A1,UNG,CASQ2,PIGT,ALDOC,CERS6,PPP1R1B,TNFRSF10B,CIDEC,MAD2L2,ANO6,NPY5R,RHBDD1,IFNAR2,TFPI2,GPX7,HAX1,HSPA8,CARD9,PPP1R15A,BTG2,ARHGEF6,NCF2,ATMIN,GAPDH,TFRC,ITGA1,AARS,SQSTM1,APOE,NME1,FBXO10,NACC2,SLC4A2,FGF2,PHLDA2,OSGIN1,GDF15,CEBPD,CDK4,DUSP22,MTFP1,IFI27,TGM2,GADD45GIP1,CS,GADD45A,CCL2,IL17D,DAB2,PIK3R2,ADORA1,TRIM29,HCAR2,RAD21,FCGR3A/FCGR3B,HEY1,FCER2,S100A1,SIGMAR1,MAPKAP1,CUL7,TRIB3,GPM6B,ST3GAL3,HSPA2,GRN,FOS,PLA2G4A,SDF2L1,LDLR,NR4A2,MYOC,NTRK3,AIMP2,SERPINH1,ATP1A2,XAF1,ARHGDIA,MAP3K8,TP53BP1,NLE1,PIN1,BMP6,ADRA1A,MAOA,RFXANK,ISM1,MT2A,PTTG1,RTN1,HSPA1A/HSPA1B,KLF6,POLR3E,DPP7,ACO2,OGFOD1,RNASE1,TYMP,ABCG1,STYXL1,HSPA5,BIN1,AP2A2,MYC,TGFBR2,PADI4,HSPA4,RHOB,MAP2K2,HDAC11,GIMAP5,NUPR1,PDCD6,GCLM,CAST,CHTF18,ATF3,MYDGF,PKP2,LAMA2,UNC13B,BTG1,VEGFC,THRA,PPP1R11,PTGDS,C9orf114,TRIM35,KLF4,FOSB,GZMH,NOL3,TRIM39,DUSP1,PLEKHF1,ALDH1A2,IGFBP3,HIF1AN,SORCS2,CAPN2,MDK,PIDD1,ESR1,DPH5,RBP4,PMEPA1,TNFAIP8,RUNX1,PTGFR,CDC20,FRZB,SRPX,TPR,PTPMT1,ATF6,NUDT2,CCL3,GLRX,HNRNPK,ETV6,SLC2A3,IRAK1,CIAPIN1,MSRB3,SHC1,RGS5,NET1,TIMP1,MCAM,SAA1,COQ8A,LOC102724428/SIK1,MCRS1,AGT,NDUFAF4,SLC20A1,PARVA,NUSAP1,RTKN,NQO1,SMAD6,EMD,ZNF16,CANX,TNFRSF14,NFE2L1,ZPR1,FAIM,SERPINE2,SLK,RCAN1,CIDEA,PMP22,CAPNS1,LOC102724788/PRODH,IRF2BP2,VAV3,CAT,CDC34,ALKBH3,DNM1L,ITSN1,SGK1,TGFBR3,COX8A,ELANE,TRAP1,HRAS,CDKN2C,SH3GLB1,NCSTN,HOXA9,SATB2,SLC4A3,ZHX2,ABCC1,SPTLC2,NPTX2,DNAJA3,IRS2,TXN,EYA2,CALCRL,NDRG1,RRBP1,THY1,STOML2,RPA1,MMP2,IER3,FAM129B,TAF9B,LDOC1,S1PR3,CDH2,TIMP4,CCND2,NR1D1,BSG,PTPA,YARS,STIP1,MAP3K20,IL10RA,SPINT2,ALDOA,MAP2K3,MAPK7,SFRP1,CYR61,IFIT2,PDGFD,ITGA7,PHLPP1,ADM,MME,SPTBN1,HIST1H1C,RAB32,ADAM17,EMILIN2,PSMB10,PAM16,TNFSF10,KAZN,MYH11,VTI1B,VCAN,UCHL1,EFNB2,CA3,TRIB1,ID1,TADA3,MTOR,ACSM5,CCL3L3,ALDH1A3,ANXA5,DAP3,SOCS2,ACSL4,PRKCE,STIM1,RASSF5,PCBP2,COL18A1,AMFR,PLAT,MBOAT7,CYP11A1,MYCN,C5AR1,UBE2M,ANGPT1,TYROBP,MGMT,DEFB1,CYP1B1,YBX2,COL5A3,SUPV3L1,KRT8,TF,MCM2,S100A9,WAS,LIMS1,SPRY2,LSP1,FCER1G,PEA15,S1PR1,IGF2BP2,MS4A2,FKBP4,BNIP3L,CBX4,GABARAP,ZFP36L2,NEDD9,PHLDA1,SERPINI1,ADRBK1,VPS28,SPHK2,FNIP2,CXCL12,ARG2,TPM1,SDC4,TAF10,PARVB,CYP26B1,TNIP1,G0S2,CRIP1,OSR1,KPNA2,SIAH2,CCDC86,PUF60,LTBR,RTN4R,KLF2,ADRA1B,DDX41,CSF3R,EIF2AK1,IGFBP6,MIF,AXIN2,SPP1,DNASE2,SGCG,LMO4,GPS2,ITPR2,LMNA,SNRK,PKN1,DPP9,GSR,STC1,PPP2R1A,ITGAM,ERCC1,PKD1,SMOX,ASIC1,RGN,GNL3,AKR1B1,MAP2K5,DDAH2,LEP,ERN1,PRDX5,PCMT1,ANTXR1,BCL2L12,PKM,ABL1,TNFAIP3,SMPD1,MYLK,IRF3,HIF1A,PDCD4,TNFRSF12A,EPHB6,SOX17,HMOX1,ZMAT3,CSPG4,FLNA,KCNMA1,RPS6KB2,KIT,HSD11B2,S100A8,NSMF,NEK7,RNF144B,SEMA3B,HCST,CUL9,STK40,PTGER4,PRNP,CD59,TAF6,CXCR4,FAM134B,AQP11,SMAD7,SCIN,NFKBIZ,CSF1R,NDUFA13,ENO1,PBX3,LPAR1,FASTK,EDNRA,NDNF,UBA1,ELK1,YME1L1,DSG2,RCAN2,P2RX7,MMP9	751	
Cellular Movement	migration	migration of cells	1.87E-24	 	1.503	 	-2.909	IL6,PPP1R14B,ATG9A,AJUBA,CSE1L,SMARCB1,TSC2,PLXNB2,AHCY,ETS1,TNFRSF21,COMP,COCH,DDIT4,DVL2,CDH5,CTSB,ALCAM,PLTP,mir-21,FTH1,FHL1,LTBP2,DAPK2,GNA11,ADIPOQ,DDX3X,TUBB2B,SYNM,LLGL1,UCP2,CD69,MESP1,PVR,IGF2R,ID3,GPR183,SWAP70,CBS/CBSL,LYN,PROCR,WBP2,SOX9,SOCS3,ADGRA2,RARRES2,HAVCR2,RABEP1,RGCC,TRPM8,FCER1A,GPC3,VNN2,TEK,RASGRP2,MARCO,KMT5A,ELN,CXCL8,NOX4,ADAMTS1,GNAZ,KANK1,BCL2L1,ADRA2A,TNS1,VHL,UBE2I,ETV5,SULF1,LOX,IGFBP4,LITAF,SFTPD,PLGRKT,ZP3,BMP2,INPPL1,HDGF,HLA-G,SH3PXD2B,EDN1,STUB1,IGSF8,ERBB2,THBS4,SRC,NLRP3,MMP28,G6PD,PLAUR,BTK,RRAS2,SPARC,COL11A1,CXCL2,MAP4K4,BMP4,CTGF,NUDT16L1,TYRO3,MST1,POMC,ACP5,MIA,SGPL1,ITGA3,LGMN,MTUS1,RARA,AFAP1,LYVE1,SFRP4,PIK3C2B,BIRC7,CMKLR1,ATG7,PLEC,HBEGF,THBD,ROR1,NINJ1,MAP3K12,RTN4,NOTCH1,COL3A1,NRP1,AKAP12,CNN2,FYN,LEPR,NQO2,HYOU1,SLC1A3,ATAT1,RUVBL1,MEOX2,ASNS,ENAH,EIF4EBP1,LYZ,CES1,JUN,CCL8,CST3,RHOD,CSF2RA,CD24,GJB2,PLXNA1,CD209,CD276,PTPRK,CSK,EGR1,ARHGAP4,SLIT2,BRMS1,AXL,RELN,ANXA3,PTGS2,TM4SF1,TNFRSF4,PFN1,LAMTOR2,FAT1,CD36,CD4,MAP1B,UNC5B,RSPO3,IKBKG,CAMK2D,PLA2G5,NAV1,GSK3B,GPC1,C1QBP,RET,FERMT3,TARS,MAPK8IP3,TPSAB1/TPSB2,APBA3,FLCN,RAP1GAP,PRKCD,CD14,IDO1,SH3BP4,SFRP2,PA2G4,NGF,PTPRF,RAB5A,CD55,NFKBIA,ANGPTL4,THBS1,DUSP10,SMO,CFB,CYGB,STK24,NCL,MAPKAPK2,ADRB2,PAK4,AP2M1,EPAS1,BHLHE41,PCOLCE2,HYAL1,LRRK2,ARPIN/C15orf38-AP3S2,PRMT1,FAF1,COL1A1,KIF2A,EBF1,MT1F,EPHB3,NUCB2,C6,KDR,NCKAP1L,CPEB1,TNFRSF19,SLIT3,CTSG,SERPINA3,SPI1,SLC9A1,EGR2,CTSH,KEAP1,MYADM,LUM,MGP,CAV1,DLG4,EBF2,HES6,SELE,DPT,PODN,TMEM201,CARMIL1,ANO6,FLOT1,TFPI2,HAX1,CARD9,FSCN1,PPP1R15A,BTG2,NCF2,ARHGEF6,CD86,ITGA1,PTPRA,APOE,NME1,SLC4A2,OSGIN1,PHLDA2,FGF2,ACKR2,GDF15,SEMA6A,CDK4,G6PC3,GRINA,TGM2,CCL2,GADD45A,SOS1,DAB2,CSNK2B,PIK3R2,ASPH,ADORA1,HCAR2,POMGNT2,FCGR3A/FCGR3B,HEY1,P4HA2,FCER2,CCR1,TJP1,ZNF580,RGS16,GRN,FOS,PLA2G4A,HP,LY96,MYOC,NR4A2,LDLR,NTRK3,FLNC,ARHGDIA,MAP3K8,SEMA3C,BMP6,ST3GAL4,QPCT,USP5,PTTG1,ITGB1BP1,HSPA1A/HSPA1B,KLF6,HSPA5,MYC,TGFBR2,ADGRF5,RHOB,MAP2K2,TMEM8B,CXCL14,STAB1,PDCD6,CAST,ATF3,PKP2,DOK2,PEX7,LAMA2,VEGFC,CAPG,THRA,PTGDS,ORMDL3,KLF4,SLC3A2,SDCBP,ORM1,MATN2,DUSP1,GIPC1,LIMA1,IGFBP3,CAPN2,MDK,DNAJB6,ESR1,C2,S100P,TNFAIP8,RUNX1,STX6,CADPS2,CCL3,GLRX,HNRNPK,ETV6,SHC1,AHNAK,NET1,TIMP1,MCAM,SAA1,MKL2,RNH1,ENPP2,AGT,VCAM1,PARVA,SLC12A2,NQO1,ST3GAL6,GNAI1,TNFRSF14,SERPINE2,CXCL16,RCAN1,ADGRG1,PMP22,CAPNS1,VAV3,CAT,NREP,CAMK1,APOB,SGK1,TGFBR3,ELANE,HRAS,CDKN2C,HOXA9,NEU1,SATB2,DGCR6L,ABR,ABCC1,NPTX2,VEGFD,DNAJA3,IRS2,TXN,EYA2,WNT5B,MATK,ARHGEF4,CALCRL,NDRG1,GUCY1A3,THY1,MMP2,TNK2,S1PR3,DOCK1,CDH2,AQP9,NR1D1,BSG,YARS,PIP5K1C,MS4A4A,IL10RA,ALDOA,RSU1,MAP2K3,RAMP3,LRP8,MAPK7,SFRP1,CYR61,IFIT2,PDGFD,ADM,MME,ADAM17,RALA,EMILIN2,WASF3,TNFSF10,MYH11,DCLK1,VCAN,IDH1,EFNB2,ID1,MTOR,GBA,CCL3L1,CCL3L3,SRGAP1,ANXA5,CMTM8,STARD13,RHOU,PRKCE,ACSL4,STIM1,LBP,RASSF5,LPP,COL18A1,SARS,NCKIPSD,PLAT,IL11RA,MBOAT7,SOX7,VPS18,C5AR1,ANGPT1,TYROBP,EPB41L4B,HDC,DPAGT1,DEFB1,CYP1B1,F11R,GLIPR2,KRT8,MCM2,S100A9,WAS,SPRY2,PELI1,LSP1,FCER1G,S1PR1,FKBP4,TAZ,NEDD9,RUFY3,FZD7,RGS1,PHLDA1,VPS28,ADRBK1,SPHK2,CXCL12,HARS,TPM1,SDC4,CYP26B1,ESAM,NARS,NEO1,KPNA2,SIAH2,LTBR,CLCN3,FBXO45,FAM65B,KLF2,MYO10,PTX3,CSF3R,IGFBP6,MIF,SPP1,LMO4,LMNA,FOXC1,PKN1,LMCD1,STC1,EFS,ITGAM,CORO1B,PKD1,ASIC1,CCL18,MAP2K5,COL7A1,AOC3,ADAMTS7,LEP,NFIX,FLRT2,PKM,ABL1,RARRES1,TNFAIP3,SMPD1,MYLK,GPR34,IRF3,HIF1A,RAMP2,PDCD4,TNFRSF12A,HMOX1,CCL13,CSPG4,FLNA,KCNMA1,KIT,S100A8,PTGER4,PRNP,NDUFAF3,FAAH,CXCR4,SMAD7,F13A1,TRIP6,NFKBIZ,CSF1R,WARS,CYTIP,LPAR1,EDNRA,NDNF,ELK1,DSG2,P2RX7,MMP9	575	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive system cancer	digestive system cancer	1.00E-23	 	0.809	 	1.295	PCLO,GARS,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,DDIT3,SLC1A5,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,GPR183,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,TCTEX1D2,PIGU,GMPPA,AKR1C3,HAVCR2,NARFL,STRN4,STC2,EEF1E1,TUBA1C,MTMR2,VNN2,NSMAF,BIRC3,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,KCNK3,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,SPARC,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,RER1,CTGF,GMDS,SNTA1,CA12,ABHD1,HOMER3,RNF38,SGPL1,TMEM268,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,PIK3C2B,APTX,ATG7,NAB1,HIGD1B,PLEC,HBEGF,CNOT10,PARP3,CREB5,FAM193B,THBD,NINJ1,CORO7/CORO7-PAM16,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,ZFP36,LEPR,ZNF234,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,PI16,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,CD276,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,KLHL35,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLEC3B,LHCGR,ZBTB47,FAM127B,RPUSD2,IKBKG,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,GOT1,EGR3,MTURN,SLC4A7,ATP10A,ALAD,ZMYND15,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,TMEM104,DAAM2,PLSCR4,EMP1,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,RAB38,ARHGAP39,SPATA18,MRPL24,ICT1,TMEM98,C4orf32,MAD2L2,CARMIL1,RUNDC3B,LAMC3,OSGIN2,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,TRAPPC5,MRPL37,FKBP2,ZDHHC4,APOE,RNF10,NME1,TTLL3,SFXN4,IGSF1,HCAR1,CEBPD,CDK4,HSD17B11,GADD45GIP1,ARFGAP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,S100A1,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,STOML1,DGAT2,OLFML3,FAM53B,PTCD1,SAA4,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ID4,HAGH,ISM1,BZW2,KIAA1551,MEGF9,TMEM8A,PPFIBP2,SLC41A2,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,RPAP1,SMPDL3A,PFKFB3,TEX264,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,KCNK12,DCHS1,SMUG1,ABCA8,CHURC1,GIPC1,RAB26,LRRC25,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,RBP4,PMEPA1,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,NFE2L1,FAM49A,FAIM,SH3PXD2A,SLK,XYLT2,CAT,TBC1D7,ISG20,MAF,TRAP1,CDKN2C,PCDH7,SH3GLB1,C1QB,ZKSCAN2,HOXA9,NOSIP,SLC4A3,ABR,ZHX2,ABCC1,CSTF2,GUCY1A3,FANCG,NAT10,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,SERTAD4,DCLK2,TRIB1,TADA3,ALDH1A3,SRGAP1,ACSL4,NAALAD2,NAA60,PRKCE,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,POLD1,STXBP6,PCDH9,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,PRND,ADPRHL2,ACTA1,PHKG1,RTCA,CSF3R,SGCG,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,PRDX5,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,FLNA,RNF144B,SNAPC4,CD59,DLGAP4,LCLAT1,PHOSPHO2,AP3D1,CPED1,ZBTB42,F13A1,MKNK2,CSF1R,TRMT61A,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,CBX7,KCNJ2,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,TMEM219,AHCY,TNFRSF21,COMP,COCH,SURF1,TMEM203,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,TSEN15,EXOSC3,ERAL1,KMT5A,ELN,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,H6PD,FIG4,RAB34,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,PC,BMP2,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,PALMD,GSS,RAD23A,MIA,NR4A3,EVI5L,ITGA3,DMRT2,PLS3,AHSA1,LGMN,IRX3,RARA,BAALC,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,TSR3,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,ALAS2,CAPRIN1,ANG,AKAP12,MAP7,SQLE,FYN,BTG3,CRTAP,HEATR1,PPP1R3C,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,THBS3,SF3B3,GPIHBP1,SDCCAG3,TIGD5,EIF4EBP1,CELF1,RPUSD3,STOM,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,MRPS18A,PLA2G2A,GBP4,OTUB1,SLC48A1,RHBDD2,GALE,ANXA3,TM4SF1,TFF3,FARP1,LAMTOR2,CD36,CD4,UNC5B,MAP1B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,FZD2,MFSD3,STX11,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,ZNHIT1,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,EXOSC4,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,--,SRM,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CFB,CDCA5,IFRD1,ATP5I,CHEK2,ZFP42,EMILIN1,BEX2,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,EIF4EBP3,CTSH,IQCC,HES6,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,ATMIN,MUSTN1,PPDPF,OSGIN1,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,CYTH3,FOS,HP,TAGLN,ZCWPW1,SLC22A18,NLE1,TTYH3,ABCC3,C11orf68,PTER,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,PPAN,LRRC8B,PCMTD2,DOK5,RUNX1,UBXN1,TPR,STX6,ABCF1,CRYL1,KIFC2,GLRX,HNRNPK,GCDH,REXO2,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP4,DECR2,MKL2,RNH1,LRPPRC,C10orf35,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,IRF2BP2,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,DNM1L,NREP,COQ9,PARP6,CADM3,SLC29A4,DPYD,CAMK1,C1orf115,APOB,ITSN1,WDR45,DNAJB4,TGFBR3,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,NPTX2,ANK2,REEP2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,TUBB2A,THY1,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,CD68,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,VTI1B,IDH1,FANCE,UCHL1,EFNB2,ID1,SLC2A6,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,TYROBP,MGMT,WDR12,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,DVL3,CBX4,FBN2,ADSSL1,DCAKD,SPHK2,IL17RC,UTP4,TPM1,TUBB,FRMD3,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PDCD4,PRKCSH,COL1A2,SOX17,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,PRNP,CYP27A1,COPS7A,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,ZDHHC7,CCDC3,WARS,CYTIP,EDNRA,RTN3,ASS1,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,VIT,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,ATG101,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,WDR86,NDST2,CYP4F11,CA4,TRPM8,TMEM169,MYL6B,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,NHP2,GIMAP6,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,SAA2,FRMD4A,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,RPLP0,ASPSCR1,SP110,PRG4,SPAG8,POLR2I,UBXN6,BIRC7,CDKN1C,SV2B,CENPB,MT1X,TIMM17B,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,IRX5,APEH,FAHD2B,CCDC136,MS4A14,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,COASY,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,NAP1L4,SLC25A13,ANKRD9,PGBD5,TRIM28,OCIAD2,NTM,ACLY,SLC2A8,DHCR24,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,RSPO3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,FAM45A,GALNT13,SLC39A3,TARS,PUS1,LRRC41,CSN1S1,DUS1L,SCRIB,TSTD1,RCE1,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,PPIP5K1,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,CCDC85A,C16orf58,ANO2,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,NCKAP1L,MPV17,SLC47A1,SLIT3,CSTA,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,SPI1,ATP2A2,MT1E,ODC1,RNASE4,CAAP1,NPL,NKAP,RCL1,PPP1R3F,GATAD2A,NUP93,GPRC5C,MYADM,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,PLD3,SOGA1,TIMM44,LHPP,MTSS1,MFAP5,RAB3IL1,REEP6,DCTD,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,ADIPOR2,IGSF10,PTPRA,DEAF1,NOL7,FBXO10,SLC4A2,PLXNA3,ZNF205,CUBN,SCUBE2,HS2ST1,GDF15,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,AHSA2,ASB1,DUSP5,POFUT2,CCL2,DAB2,ASPH,ADORA1,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,LDLR,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NCDN,NOC3L,TPPP3,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,GDE1,CXCL14,ZNF598,GYPE,NUPR1,STAB1,NBAS,ATF3,PKP2,RILPL1,ZNF282,THRA,TRIM35,CDC42BPB,TLN2,MATN2,PLEKHF1,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,FAM20B,SLC1A4,CDC20,SRPX,FRZB,SCARA5,MECR,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,PGAP2,ST3GAL6,GNAI1,ZFPL1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,NUDT14,VWA5A,NCOA7,CLCNKA,SPTLC2,SLC16A2,VEGFD,RPS2,ALPK1,MRPL4,TMEM9B,RIMS3,RPA1,SERINC1,GRAMD1A,LONP2,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,YARS,MAP3K20,IL10RA,ALDOA,RPL6,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,EMILIN2,RERGL,PDDC1,ACSF2,NT5C,PFKL,SCO1,FAXDC2,TMEM94,MTOR,WDFY1,TARS2,DHPS,DAP3,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,HGH1,MCM2,UQCR10,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,MAPRE3,FZD7,MVD,NAGK,CYTOR,SERPINI1,PTPN23,VPS28,XXYLT1,FNIP2,DYNLT1,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,GPS2,ZNF408,MACROD1,MYOF,MARS,RPL9,PANK1,R3HDM4,RRP7A,HSPA13,RGN,LSM7,MAP2K5,RNPEP,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,ERN1,C1QTNF1,BCL2L12,PNMAL1,AADAC,FUBP3,SRGN,RPS6KB2,HSD11B2,S100A8,ZNHIT2,MYO16,PRRT3,TMEM132B,SPOCD1,FRMD1,VWCE,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,TOMM40L,RPE,AXIN1,PPP1R14B,ATG9A,BCAT2,PLXNB2,AMHR2,PTGIS,SLC2A5,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,HSDL1,ABCC9,ZNF521,KIAA1549L,SPATS2L,PVR,GCNA,C1orf123,SOCS3,ARSD,SFMBT1,RABEP1,ANKMY1,FCER1A,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,SNX16,ESPNL,GTPBP2,SRC,IPO4,POLR3B,PRUNE2,GYG2,SLC15A4,MKX,KIF21A,AFAP1,CMKLR1,RNASEH2A,NGRN,CLEC4F,GAMT,EPB42,ME2,TBL3,TRPT1,C20orf96,ENAH,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,CCDC8,SLIT2,TMEM42,GABRE,DCAF13,RBM42,GTPBP3,BRINP2,UAP1L1,CILP,NENF,MAMSTR,LRFN4,TNFRSF4,PFN1,C8orf82,FAT1,TCEB2,WDR5,GSPT1,BCL7C,ALDH3A2,PHPT1,BCKDK,EPB41L1,C7orf50,PHACTR3,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,RARRES3,IDO1,TBC1D16,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,STK24,KCTD1,NCL,MAPKAPK2,CCDC189,RHBDD3,COL5A2,LRRC2,METTL1,PCOLCE2,VSIG4,DHX37,PRMT1,COLEC11,PLBD2,TMEM2,GLMP,ACAT1,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,ST6GALNAC2,KANK3,CEP170B,MGP,CAV1,ATF4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,TMEM201,TIMM8B,SMG5,FLOT1,THOP1,RHBDD1,IFNAR2,TRAPPC3,ZNF579,CARD9,IFT122,NRDE2,CTSA,LRRN3,FBXW5,FSCN1,VARS2,TRPC4AP,NCF2,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,CXorf57,ADPGK,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,THOC3,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,B4GALT7,ZMYND19,CHDH,FAM102A,PGA5 (includes others),RANGAP1,IL34,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,PLA2G4A,SELM,NRXN2,SNUPN,NR4A2,FLNC,FAM129A,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,ABCG1,C16orf91,HDAC11,GCLM,CHTF18,CAST,CHMP1A,DOK2,SRPRB,ENKD1,ANO1,CYB561,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,TXNRD2,DOCK6,NMT1,CADPS2,ATF6,NET1,ENPP2,MRPL40,LONP1,ZNF135,PSAT1,ZNF358,SLC22A12,TUBG1,SMAD6,ADGRG1,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,DGCR6L,PEX16,NMUR2,GAA,IRS2,TXN,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,PTS,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,LBP,PRPF31,AMFR,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,SDC4,TAF10,DCAF10,PLEKHG4,CEL,CYP26B1,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,LMCD1,EFS,C9orf9,ITGAM,ERCC1,PKD1,PLEKHH3,AK2,RNF165,NFIX,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,SEPHS2,NKD2,AEBP1,CCL13,PCK2,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,ACTN1,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,EXOC4,DIP2C,LPAR1,JCHAIN,ELK1,DSG2	2198	
Cancer, Organismal Injury and Abnormalities	benign neoplasia	benign neoplasia	7.85E-22	 	0.030	 	1.229	SLIT3,CBX7,RPE,AXIN1,ASS1,COL8A1,NPAS2,ATP2A2,ODC1,POR,CCND3,AJUBA,CYBA,KEAP1,SMARCB1,TSC2,MTHFD2,MGP,PLXNB2,UNG,TSHZ2,ALDOC,PTGIS,SLC2A5,ALDH1B1,DPT,PLD3,MFAP5,NDUFS7,IFNAR2,TFPI2,PLAG1,CDH5,MRPL17,CTSB,ALCAM,P2RX6,BYSL,mir-21,FTH1,NOL7,APOE,COL4A5,DDIT3,FGF2,PHLDA2,ZNF205,CUBN,CEBPD,CDK4,ADIPOQ,COL15A1,COL16A1,TGM2,DTNA,DUSP5,GADD45A,SOS1,DAB2,RAD21,FCGR3A/FCGR3B,CNFN,MECOM,DGAT2,TRIB3,GPM6B,IGF2R,FOS,HP,AFF3,ZFPM2,NR4A2,ATP6V1F,NTRK3,LYN,XAF1,SOX9,NLE1,SEMA3C,BMP6,MXRA5,ID4,ADRA1A,MAOA,LIG1,SOCS3,MEGF9,PTTG1,DPYSL4,PARP2,NTMT1,RGCC,RNASE1,CES2,CEBPG,MYC,TGFBR2,GPX3,MAP2K2,CXCL14,ERAL1,STAB1,TEK,SMPDL3A,H19,THRA,STX1A,ERCC2,BCL2L1,KCNG1,ABCA8,ADRA2A,DUSP1,ALDH1A2,IGFBP3,BAP1,ESR1,CCDC80,VHL,UBE2I,RBP4,POLR3F,IGFBP4,CARS,DNASE1L3,SCARA5,GLRX,ETV6,POLR1C,SHC1,ALDH2,COL6A1,RGS5,TIMP1,MCAM,ERBB2,PSAT1,SRC,VCAM1,NUSAP1,COL6A2,SLC12A2,NQO1,CLEC16A,SERPINE2,VAV3,LPAR5,ITM2C,COL11A1,DPYD,C1orf115,BMP4,AHCYL1,SGK1,TGFBR3,CMTM4,MAF,CA12,HRAS,CDKN2C,POMC,ACP5,PPP4C,GTF2IRD1,ADGRL1,MIA,NR4A3,PKIA,WNT5B,PIK3C2B,CALCRL,CAPN6,ATG7,NDRG1,SLC24A3,TUBB2A,DKC1,THY1,MMP2,HMGA1,PARP3,AP2S1,LARGE1,CDH2,SRGAP3,CCND2,NPRL3,SPINT2,ALDOA,TRO,GLUL,HSPB7,LRP8,MAPK7,BACE2,SFRP1,CYR61,NOTCH1,NRP1,COL3A1,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,GSTM5,UQCRH,LEPR,PAM16,TNFSF10,FKBP1A,RUVBL1,MYH11,DCLK1,VCAN,EIF4EBP1,IDH1,FANCE,COL5A1,ID1,CADM2,MTOR,JUN,CMTM8,ANXA5,DAP3,CLMN,SLC19A1,PRKCE,COL22A1,CD24,TPO,COL18A1,ECM2,PTPRT,PI4KA,MYH1,CCDC68,EGR1,MGMT,COL12A1,DDX24,SLIT2,RELN,AXL,POLD1,STXBP6,CYP1B1,PLA2G2A,RHPN2,COL5A3,SLC48A1,S100A9,ANXA3,LSP1,PEA15,NR5A2,PTGS2,CYP2C8,PHLDA1,CLEC3B,LHCGR,CXCL12,ALDH1A1,PLCE1,SDPR,DHTKD1,SLC7A5,GSK3B,RET,ADRA1B,PDK4,AXIN2,HNMT,SPP1,RPL9,FLCN,C9orf16,PPP2R1A,SORD,COL6A3,PKD1,PRKCD,SLC22A5,SCRIB,CRABP2,AK2,COL7A1,LEP,EPB41L3,PRDX5,FLRT2,ANTXR1,PKM,ABL1,RBBP8,SLC7A1,TNFAIP3,TET1,MAN1B1,HIF1A,RAMP2,CDKN2B,PDCD4,TNFRSF12A,COL1A2,EPHB6,HMOX1,AEBP1,HINT1,NFKBIA,GNG11,THBS1,SMO,KIT,MICALL1,HSD11B2,ARHGEF2,S100A8,RNF144B,ASAP3,CHEK2,PTGER4,ADRB2,COL5A2,DLGAP4,ATP2C1,HYAL1,PERP,LRRK2,VSIG4,NFKBIZ,CSF1R,COL1A1,C2orf88,ITPA,LPAR1,JCHAIN,PAG1,LRP1B,ACAT1,EPHB3,EDNRA,GAP43,RDH5,KDR,RCAN2,ATP6V1B2,MMP9	347	
Cell Death and Survival	apoptosis	apoptosis of tumor cell lines	8.71E-21	Decreased	-3.039	 	-2.524	CSTA,AXIN1,CTSG,SERPINA3,IL6,SLC9A1,SPI1,ODC1,EGR2,CCND3,CSE1L,TSC2,CAV1,ATF4,HIPK2,ETS1,TNFRSF21,CERS6,DDIT4,PPP1R1B,TNFRSF10B,IFNAR2,HAX1,HSPA8,CARD9,DVL2,PDLIM7,PPP1R15A,BTG2,ARHGEF6,CTSB,ATMIN,GAPDH,ALCAM,TFRC,ACACA,SQSTM1,TRIAP1,mir-21,FTH1,APOE,NME1,GADD45B,NACC2,DDIT3,DAPK2,FGF2,OSGIN1,GNA11,GDF15,CEBPD,ADIPOQ,MTFP1,DIABLO,TGM2,RABL6,CS,GADD45A,IL17D,DAB2,ADORA1,TRIM29,HCAR2,RAD21,ATN1,FCER2,MAPKAP1,MECOM,IGF2R,ID3,GRN,FOS,NR4A2,HNRNPH1,NTRK3,AIMP2,LYN,XAF1,ARHGDIA,SOX9,TP53BP1,BMP6,MAOA,LIG1,MT2A,SOCS3,PTTG1,RTN1,HSPA1A/HSPA1B,KLF6,ACO2,FCER1A,OGFOD1,RNASE1,TYMP,STYXL1,DNAJC15,HSPA5,CBX5,AP2A2,MYC,TGFBR2,PADI4,HSPA4,CTSD,RHOB,HDAC11,CARD8,GIMAP5,NUPR1,CAST,BIRC3,CXCL8,NOX4,ATF3,THRA,PPP1R11,KLF4,TXNRD1,FOSB,BCL2L1,NOL3,TRIM39,DUSP1,BAP1,IGFBP3,SORCS2,CAPN2,MDK,PIDD1,ESR1,CCDC80,VHL,DPH5,PMEPA1,TNFAIP8,PEBP1,RUNX1,SULF1,IGFBP4,CDC20,SRPX,BMP2,ATF6,GLRX,HNRNPK,IRAK1,HLA-G,SHC1,EDN1,STUB1,TIMP1,ERBB2,MCRS1,AGT,NDUFAF4,SRC,PARVA,RTKN,NQO1,SMAD6,G6PD,PLAUR,NFE2L1,FAIM,BTK,RCAN1,CAPNS1,LOC102724788/PRODH,IRF2BP2,CAT,SPARC,ING1,CYB5A,ALKBH3,DNM1L,RPLP0,CTGF,MSRB2,BMP4,ITSN1,GMDS,SGK1,TGFBR3,TYRO3,COX8A,ELANE,TRAP1,HRAS,CDKN2C,MIA,SATB2,AHSA1,MTUS1,RARA,ABCC1,DNAJA3,TXN,MCL1,SFRP4,BIRC7,CAPN6,CDKN1C,ATG7,NDRG1,CENPB,THY1,HBEGF,STOML2,RPA1,JUNB,IER3,HMGA1,ROR1,LDOC1,S1PR3,MAP3K12,DPH2,TIMP4,PDE1B,RTN4,MAP2K3,MAPK7,SFRP1,CYR61,NOTCH1,NRP1,PHLPP1,ADM,MME,CNN2,AKAP12,FYN,RAB32,ADAM17,EMILIN2,ZFP36,LEPR,SIN3B,TNFSF10,KAZN,CASP4,ASNS,VCAN,EIF4EBP1,UCHL1,KLF9,MCOLN1,ID1,LCMT1,MTOR,ACSM5,JUN,CSF2RA,PRKCE,CD24,STIM1,RASSF5,PCBP2,COL18A1,ACVR1C,PLAT,RPS24,WSB1,MYCN,C5AR1,EGR1,TRIM28,ARHGAP4,DEFB1,CCDC8,CYP1B1,OTUB1,IMMT,DHCR24,TF,S100A9,WAS,LIMS1,BMF,SPRY2,LSP1,PEA15,IGF2BP2,BNIP3L,PTGS2,NEDD9,TFF3,PRPF19,ADRBK1,CD4,UNC5B,SPHK2,CXCL12,IKBKG,G0S2,ETS2,KPNA2,SIAH2,GSK3B,PUF60,RET,KLF2,IGFBP6,MIF,PTPRE,SPP1,FST,LMO4,GPS2,ITPR2,EGR3,HSPA9,PAWR,PKN1,RASD1,ITPK1,PPP2R1A,ITGAM,SMOX,PRKCD,IDO1,CRABP2,AKR1B1,MAP2K5,LEP,SFRP2,PA2G4,ERN1,BCL2L12,PKM,ABL1,TNFAIP3,SMPD1,IRF3,HIF1A,NGF,PDCD4,EPHB6,HMOX1,HINT1,ZMAT3,MAN2C1,CD55,NFKBIA,CSPG4,THBS1,MARCH8,DKK3,SMO,KIT,S100A8,NEK7,RNF144B,SEMA3B,HCST,SULF2,NCL,CUL9,CHEK2,PRNP,BEX2,CD59,PAK4,TAF6,EPAS1,CXCR4,HYAL1,SMAD7,SCIN,NFKBIZ,CSF1R,NDUFA13,PRMT1,FAF1,COL1A1,ENO1,EBF1,PBX3,MT1F,DSG2,MMP9	382	
Organismal Injury and Abnormalities	growth	growth of lesion	2.96E-20	 	1.124	 	-0.539	TLE1,IL6,SPI1,ODC1,CCND3,CYBA,TSC2,LUM,CAV1,KAT2A,AHCY,CERS6,ETS1,CLEC4G,SELE,TNFRSF10B,GFM1,HSPA8,PYGO2,DVL2,CDH5,BTG2,CTSB,GAPDH,ALCAM,ITGA1,SQSTM1,PTPRA,mir-21,FTH1,APOE,NME1,FHL1,DDIT3,FGF2,GDF15,ADIPOQ,CDK4,TGM2,CCL2,GADD45A,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,ID3,GRN,FOS,PLA2G4A,NR4A2,PROCR,TP53BP1,MAP3K8,SOX9,PIN1,BMP6,MAOA,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,KLF6,DIRAS1,HSPA5,GPC3,GPNMB,MYC,TGFBR2,HSPA4,RHOB,MAP2K2,CXCL14,PFKFB3,CXCL8,NOX4,ATF3,H19,ADAMTS1,BAMBI,VEGFC,TRIM35,AKR1B10,SLC3A2,BCL2L1,CBX1,NOL3,DUSP1,APCDD1,IGFBP3,CAPN2,VPS37A,DNAJB6,ESR1,VHL,RUNX1,LOX,LITAF,BMP2,TPR,EMX2,CCL3,HDGF,RAP1GDS1,HLA-G,SHC1,EDN1,TIMP1,MCAM,ERBB2,MCRS1,GJA4,AGT,SRC,NLRP3,PLAUR,BTK,CXCL16,RCAN1,ADGRG1,CAPNS1,RRAS2,TACC2,VAV3,SPARC,TSC22D1,EFEMP2,BMP4,CTGF,COX8A,ELANE,CA12,HRAS,MST1,PEG10,ABCC1,ANK2,VEGFD,TXN,MCL1,ARHGEF4,ATG7,NDRG1,PLEC,HBEGF,MMP2,HMGA1,THBD,SH3GL1,TIMP4,ASGR1,BSG,MAP2K3,MAPK7,SFRP1,CYR61,PDGFD,NOTCH1,DUS2,ANG,PHLPP1,NRP1,ADM,MME,RALA,ZFP36,BTG3,LEPR,HYOU1,TNFSF10,RUVBL1,TAX1BP3,VCAN,EIF4EBP1,UCHL1,EFNB2,ID1,MTOR,KAT2B,JUN,CSF2RA,CST3,CD24,PRKCE,COL18A1,ACVR1C,PLAT,MYCN,SOX7,CTSK,MGMT,EGR1,ACLY,AXL,S100A9,WAS,FCER1G,PTGS2,NEDD9,PHLDA1,TFF3,TNFRSF4,ADRBK1,TFG,CD36,SPHK2,CXCL12,TPM1,PGD,PLCE1,SIAH2,GSK3B,LTBR,GPC1,RET,CSF3R,MIF,PTPRE,SPP1,FST,PAWR,INHBB,SRSF3,ITGAM,RAP1GAP,PRKCD,RGN,CRABP2,CCL18,AKR1B1,UVRAG,MAP2K5,AOC3,SFRP2,LEP,PA2G4,ANTXR1,PKM,ABL1,IRF3,HIF1A,NGF,CDKN2B,NELFE,HMOX1,ZMAT3,NFKBIA,ANGPTL4,THBS1,FLNA,SRGN,SMO,KIT,CYGB,SEMA3B,CHCHD4,HCST,NDUFAF3,BEX2,CD59,COX17,EPAS1,CXCR4,HYAL1,RNF126,LRRK2,CSF1R,NDUFA13,TRIM69,ACAT1,KDR,MMP9	271	
Cardiovascular System Development and Function, Organismal Development	vasculogenesis	vasculogenesis	6.44E-20	 	-1.520	 	-4.171	SLIT3,KCNJ2,COL8A1,SERPINA3,C1QA,IL6,ODC1,POR,CYBA,MGP,CAV1,HIPK2,ETS1,HEYL,SELE,COMP,C1GALT1C1,SMOC2,TMEM100,CDH5,CTSB,ALCAM,ITGA1,ADIPOR2,mir-21,APOE,GBP1,DDIT3,FGF2,CFC1/CFC1B,SEMA6A,ADIPOQ,COL15A1,TGM2,CCL2,GADD45A,TIPARP,SOS1,DAB2,TNMD,CYP51A1,HEY1,ZNF580,CUL7,MESP1,ID3,GRN,PLA2G4A,ZFPM2,KIF7,CBS/CBSL,SERPINH1,ATP6V0A2,PROCR,ARHGDIA,BMPER,MAN2B1,SEMA3C,BMP6,SOCS3,ITGB1BP1,RGCC,TYMP,GPC3,MYC,TGFBR2,RHOB,CXCL14,STAB1,PDCD6,GCLM,TEK,ELN,PFKFB3,CXCL8,NOX4,ATF3,ADAMTS1,MYDGF,STK39,LAMA2,VEGFC,THRA,ORM1,ADRA2A,ALDH1A2,HIF1AN,IGFBP3,COMMD1,FZD5,MDK,MEGF8,ESR1,VHL,RUNX1,SULF1,LOX,IGFBP4,BMP2,ETV6,SHC1,EDN1,RGS5,TIMP1,SAA1,MKL2,ENPP2,ERBB2,AGT,THBS4,SRC,VCAM1,AP1S2,SMAD6,G6PD,PLAUR,RCAN1,CAPNS1,CAT,SPARC,CXCL2,PNPLA6,BMP4,APOB,CTGF,TGFBR3,HRAS,NEU1,SGPL1,RARA,VEGFD,HEY2,PIK3C2B,ATG7,GUCY1A3,PCSK5,THY1,HBEGF,MMP2,JUNB,THBD,ROR1,S1PR3,CDH2,BSG,YARS,PTPRB,MAP2K3,LRP8,MAPK7,CYR61,ITGA7,NOTCH1,ANG,NRP1,ADM,LEPR,TNFSF10,MEOX2,EFNB2,ID1,MTOR,JUN,CST3,PRKCE,EGFL6,STIM1,COL18A1,SARS,NCKIPSD,PLOD3,PLAT,PTK7,GSTM1,C5AR1,ANGPT1,EGR1,SLIT2,BRMS1,AXL,CYP1B1,WARS2,F11R,S100A9,TF,PPP1R16B,SPRY2,S1PR1,PTGS2,CHD7,TM4SF1,CD36,UNC5B,CXCL12,SDC4,METAP2,ESAM,GSK3B,LTBR,GPC1,KLF2,FERMT3,PTX3,SPP1,EGR3,MYOF,FOXC1,STC1,ATPIF1,ITGAM,PRKCD,AKR1B1,TMOD1,MAP2K5,SFRP2,LEP,ERN1,SLC4A11,PKM,TNFAIP3,SMPD1,HIF1A,NGF,RAMP2,TNFRSF12A,SOX17,HMOX1,NFKBIA,ANGPTL4,CSPG4,FLNA,KCNMA1,THBS1,SMO,CFB,KIT,CYGB,S100A8,SEMA3B,MAPKAPK2,EPAS1,CXCR4,SMAD7,CSF1R,EDF1,COL1A1,WARS,EPHB3,EDNRA,NDNF,C6,KDR,RCAN2,MMP9	254	
Cancer, Organismal Injury and Abnormalities	growth	growth of tumor	9.37E-20	 	1.090	 	-0.553	TLE1,IL6,SPI1,ODC1,CCND3,CYBA,TSC2,LUM,CAV1,KAT2A,AHCY,CERS6,ETS1,CLEC4G,SELE,TNFRSF10B,GFM1,HSPA8,PYGO2,DVL2,CDH5,BTG2,CTSB,GAPDH,ALCAM,ITGA1,SQSTM1,PTPRA,mir-21,FTH1,NME1,FHL1,DDIT3,FGF2,GDF15,ADIPOQ,CDK4,TGM2,CCL2,GADD45A,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,ID3,GRN,FOS,PLA2G4A,NR4A2,PROCR,TP53BP1,MAP3K8,SOX9,PIN1,BMP6,MAOA,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,KLF6,DIRAS1,HSPA5,GPC3,GPNMB,MYC,TGFBR2,HSPA4,RHOB,MAP2K2,CXCL14,PFKFB3,CXCL8,NOX4,ATF3,H19,ADAMTS1,BAMBI,VEGFC,TRIM35,AKR1B10,SLC3A2,BCL2L1,CBX1,NOL3,DUSP1,APCDD1,IGFBP3,CAPN2,VPS37A,DNAJB6,ESR1,VHL,RUNX1,LOX,LITAF,BMP2,TPR,EMX2,CCL3,HDGF,RAP1GDS1,HLA-G,SHC1,EDN1,TIMP1,MCAM,ERBB2,MCRS1,GJA4,AGT,SRC,NLRP3,PLAUR,BTK,CXCL16,RCAN1,ADGRG1,RRAS2,TACC2,VAV3,SPARC,TSC22D1,EFEMP2,BMP4,CTGF,COX8A,ELANE,CA12,HRAS,MST1,PEG10,ABCC1,ANK2,VEGFD,TXN,MCL1,ARHGEF4,ATG7,NDRG1,PLEC,HBEGF,MMP2,HMGA1,THBD,SH3GL1,TIMP4,ASGR1,BSG,MAP2K3,MAPK7,SFRP1,CYR61,PDGFD,NOTCH1,DUS2,ANG,PHLPP1,NRP1,ADM,MME,RALA,ZFP36,BTG3,LEPR,HYOU1,TNFSF10,RUVBL1,TAX1BP3,VCAN,EIF4EBP1,UCHL1,EFNB2,ID1,MTOR,JUN,KAT2B,CSF2RA,CST3,CD24,PRKCE,COL18A1,ACVR1C,PLAT,MYCN,SOX7,CTSK,MGMT,EGR1,ACLY,AXL,S100A9,WAS,FCER1G,PTGS2,NEDD9,PHLDA1,TFF3,TNFRSF4,ADRBK1,TFG,CD36,SPHK2,CXCL12,TPM1,PGD,PLCE1,SIAH2,GSK3B,LTBR,GPC1,RET,CSF3R,MIF,PTPRE,SPP1,FST,PAWR,INHBB,SRSF3,ITGAM,RAP1GAP,PRKCD,RGN,CRABP2,CCL18,AKR1B1,UVRAG,MAP2K5,AOC3,SFRP2,LEP,PA2G4,ANTXR1,PKM,ABL1,IRF3,HIF1A,NGF,CDKN2B,NELFE,HMOX1,ZMAT3,NFKBIA,ANGPTL4,THBS1,FLNA,SRGN,SMO,KIT,CYGB,SEMA3B,CHCHD4,HCST,NDUFAF3,BEX2,CD59,COX17,EPAS1,CXCR4,HYAL1,RNF126,LRRK2,CSF1R,NDUFA13,TRIM69,ACAT1,KDR,MMP9	269	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of tumor cell lines	2.03E-19	Increased	2.156	 	0.019	CBX7,AXIN1,IL6,POR,CCND3,CSE1L,AJUBA,SMARCB1,ETS1,HEYL,RBM38,COMP,DVL2,CTSB,PSMA4,ALCAM,ACACA,mir-21,FTH1,DDIT3,DAPK2,ADIPOQ,FNTA,SYNM,DIABLO,RABL6,LLGL1,MECOM,IGF2R,ID3,LYN,WBP2,SOX9,LIG1,SOCS3,AKR1C3,HAVCR2,GPC3,CTSD,ERAL1,TEK,CXCL8,NOX4,H19,ADAMTS1,AKR1B10,BCL2L1,VHL,UBE2I,PEBP1,LOX,IGFBP4,PC,BMP2,HDGF,EDN1,STUB1,ERBB2,SRC,USMG5,G6PD,PLAUR,SERTAD1,MT1A,RBCK1,BTK,ANO3,SPARC,ING1,MAP4K4,KCND2,EIF3C,BMP4,CTGF,TYRO3,RAN,POMC,RAD23A,MIA,SP110,AHSA1,MTUS1,RARA,AFAP1,MCL1,SFRP4,PIK3C2B,BIRC7,CAPN6,CDKN1C,ATG7,CENPB,HBEGF,GRK5,JUNB,HMGA1,MBD2,THBD,ROR1,SH3GL1,NOTCH1,ANG,NRP1,AKAP12,CNN2,FYN,ZFP36,TTLL4,NAA35,ASNS,H2AFZ,ENAH,EIF4EBP1,JUN,KAT2B,CD24,MEG3,HGS,ACVR1C,WSB1,PTPRK,TRIM28,EGR1,AXL,ACLY,COPS3,OTUB1,SLC2A8,LMO3,RNF144A,IMMT,GCAT,PTGS2,ARID4A,TNFRSF4,PFN1,CD4,MAP1B,DNAJB2,WDR5,IKBKG,CAMK2D,SLC25A6,ALDH1A1,PLCE1,ETS2,GSK3B,AAGAB,C1QBP,GPC1,RET,HK1,PTPRE,FST,GSDMB,USP36,FZD9,NDUFAF2,RASD1,ZFAND3,COL6A3,RAP1GAP,PRKCD,RARRES3,IDO1,RCE1,CRABP2,UVRAG,SRM,PA2G4,ATF5,NGF,PTPRF,NFKBIA,ANGPTL4,DKK3,THBS1,SMO,CDCA5,STK24,NCL,MAPKAPK2,CHEK2,EMILIN1,BEX2,PAK4,HYAL1,PRMT1,EMP1,COL1A1,TMEM2,ACAT1,NUCB2,GAP43,KDR,SLIT3,CTSG,SPI1,ATP2A2,SLC9A1,CLIP1,ODC1,BOP1,EGR2,GNA15,KIF1A,KEAP1,CAV1,HES6,CDC16,HIPK2,KAT2A,SELE,PPP1R1B,TNFRSF10B,FLOT1,TFPI2,MICU1,FSCN1,BTG2,GAPDH,TFRC,ITGA1,NME1,NACC2,OSGIN1,FGF2,HCAR1,GDF15,CDK4,CEBPD,COPS8,TGM2,GADD45GIP1,DUSP5,CCL2,GADD45A,IL34,DAB2,CSNK2B,ASPH,RAD21,FCER2,S100A1,CUL7,RGS16,TRIB3,GRN,PLA2G4A,FOS,NR4A2,NTRK3,PIN1,BMP6,PPIL1,ABCB6,MT2A,USP5,PTTG1,KLF6,CES2,CD163,HSPA5,BIN1,MYC,TGFBR2,PADI4,RHOB,PFKFB3,ATF3,DOK2,ZNF282,VEGFC,THRA,TRIM35,ANO1,KLF4,SLC3A2,FOSB,CBX1,SDCBP,TRIM39,DUSP1,IGFBP3,MDK,ESR1,PMEPA1,INO80B,RUNX1,TNFAIP8,CCL3,ETV6,HNRNPK,RAP1GDS1,SHC1,MFSD12,AHNAK,NET1,LOC102724428/SIK1,MCRS1,CIZ1,AGT,GJA4,NDUFAF4,VCAM1,RTKN,NQO1,LOC102724788/PRODH,TACC2,VAV3,CAT,TBC1D7,ALKBH3,NNAT,APOB,DNAJB4,SGK1,TGFBR3,HRAS,NCSTN,PEG10,NMUR2,CSTF2,DNAJA3,IRS2,TXN,MATK,NDRG1,TUBB2A,NAT10,MMP2,TNK2,IER3,TAF9B,S1PR3,TIMP4,CCND2,VKORC1,BSG,PIP5K1C,ALDOA,MAP2K3,SFRP1,BACE2,MAPK7,CYR61,ITGA7,PHLPP1,ADM,ADAM17,EMILIN2,RALA,CHCHD6,TNFSF10,VCAN,UCHL1,ID1,CA3,MTOR,TADA3,STARD13,SLC19A1,PRKCE,ACSL4,STIM1,RASSF5,COL18A1,PRPF31,PLAT,GSTM1,MYCN,UBE2M,MGMT,NABP1,DEFB1,CINP,WDR12,CYP1B1,KRT8,MCM2,TF,WAS,SPRY2,CNN1,FCER1G,NR5A2,DVL3,NEDD9,CYP2C8,PHLDA1,VPS28,SPHK2,CXCL12,TPM1,SDC4,TUBB,PARVB,CEL,PGD,EIF5,SLC7A5,NEO1,KPNA2,CLCN3,KLF2,ADRA1B,PDK4,EIF2AK1,MIF,SPP1,GPS2,SNRK,FOXC1,SRSF3,CCNG2,PPP2R1A,ERCC1,SRPK3,SMOX,EXTL3,GNL3,CCL18,LEP,EPB41L3,ANTXR1,PKM,ABL1,RARRES1,GPR34,MYLK,HIF1A,NAA10,CDKN2B,PRKCSH,PDCD4,SOX17,EPHB6,HMOX1,ADSL,PCK2,FLNA,CSPG4,KIT,HSD11B2,ARHGEF2,NR2F6,SEMA3B,ACTN1,NDUFAF3,PRNP,CD59,TAF6,MIPEP,CXCR4,SMAD7,RNF126,ZBTB7C,MKNK2,NDUFA13,PBX3,LRP1B,UBA1,ELK1,DSG2,P2RX7,MMP9	466	
Cancer, Organismal Injury and Abnormalities	adenocarcinoma	adenocarcinoma	1.48E-18	 	-1.510	 	-0.682	PCLO,VAC14,LRRN4CL,GLB1,AJUBA,SMARCB1,MARCH2,DMAP1,ETS1,RNPEPL1,SRPRA,KIAA1147,CDH5,NPR3,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,SLC1A5,KIAA1211L,TUBB2B,C1R,RABL6,GPC6,MTSS1L,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,WBP2,PIGU,GMPPA,AKR1C3,HAVCR2,RGCC,NARFL,ANKDD1A,TUBA1C,VNN2,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,NAGLU,PSME4,BAIAP2L2,POLD2,MLKL,FAM134A,RAB11FIP5,SUN1,CARS,ZP3,FLRT1,ADH1C,CLUAP1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,SH3PXD2B,IGSF8,CD1C,ELMOD3,NLRP3,FAAP100,PYGB,SNX27,CLEC16A,BTK,RRAS2,ACADVL,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,GFPT1,CTGF,MSRB2,GMDS,SNTA1,CA12,HOMER3,PPP4C,RNF38,SGPL1,SLC22A15,ZNF395,ZNF605,FAM124B,PNKD,LSS,MCL1,TMEM39B,PPIL6,PIK3C2B,APTX,DFNA5,ATG7,NAB1,PLEC,HBEGF,TMEM267,CNOT10,GRK5,PARP3,CREB5,THBD,NINJ1,ACAD11,CORO7/CORO7-PAM16,MAP3K12,ISLR,NCLN,GDPD5,KIAA0368,RSAD1,AKR1C4,TMEM158,NOTCH1,EOGT,NRP1,COL3A1,SUSD2,CPSF2,FCGRT,ABI3BP,SERAC1,RP9,ZFP36,LEPR,ZNF234,NQO2,EFHD1,FKBP1A,MEOX2,CST3,ZNF608,DPCD,TUB,COL22A1,TXNL1,AHNAK2,GJB2,NPRL2,LIMCH1,PRPH,CD209,FCRLB,STAMBPL1,BLMH,EGR1,COL12A1,DAAM1,MED30,DDX24,RELN,COPS3,C8orf33,SBF1,CELF2,KDELR3,TMEM63B,PTGS2,AOX1,ARID4A,CHD7,C1orf186,COBLL1,CLIP3,CLEC3B,LHCGR,ZBTB47,RPUSD2,CNDP2,PTGES2,DHTKD1,COMT,CYP4X1,NMNAT2,WDR46,EGR3,MTURN,FBXO22,SLC4A7,ATP10A,NDUFAF2,ZMYND15,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,NGF,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,TMEM104,SYBU,COL1A1,FAF1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,CYBA,ARHGAP39,SPATA18,MRPL24,ICT1,C4orf32,MAD2L2,CARMIL1,RUNDC3B,LAMC3,OSGIN2,HAX1,WDR81,HDDC2,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,MRPL37,FKBP2,ZDHHC4,APOE,NME1,TTLL3,NACC2,IGSF1,CEBPD,CDK4,CTDSPL,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,HELZ,SPRY1,MLF2,NLGN4X,DGAT2,OLFML3,FAM53B,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,MAN2B1,MSRA,PPIL1,HAGH,ISM1,BZW2,KIAA1551,MEGF9,USP5,TMEM8A,PPFIBP2,SLC41A2,SLC35F6,DRG2,CD163,GPNMB,MYC,TGFBR2,GPX3,RHOB,MOCOS,METTL5,TMEM234,LILRB5,NEDD4L,KIF25,FMO4,RPAP1,GULP1,POLR3C,SMPDL3A,PFKFB3,FMO2,STARD5,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,VARS,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,LPAR5,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,NOSIP,SLC4A3,ABR,ABCC1,ZHX2,CSTF2,GUCY1A3,NAT10,MMP2,IER3,SCNN1D,RAE1,DOCK1,AQP9,PIP5K1C,C11orf80,MS4A7,TRO,HSPB7,BACE2,PDGFD,HIST2H2AA3/HIST2H2AA4,SCAP,CHCHD6,KHDC1,VCAN,TRIB1,TADA3,SRGAP1,ALDH1A3,NAALAD2,NAA60,PRKCE,ACSL4,AKR1B15,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,MRPL51,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,ADRBK1,LARS,ADPRHL2,ACTA1,RTCA,PHKG1,CSF3R,SGCG,ITPR2,LMNA,DPP9,GSR,TRAPPC9,PCGF1,CUEDC1,THSD7B,DRAP1,GDI1,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,RAMP2,ADSL,ZMAT3,FLNA,RNF144B,RAB11FIP3,SNAPC4,CD59,DLGAP4,LCLAT1,AP3D1,CPED1,ZBTB42,F13A1,MKNK2,CSF1R,PTGES3L-AARSD1,ITPA,DYM,ATP6V1B2,CARM1,CBX7,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,EIF3B,CSE1L,C6orf136,MAP1A,AHCY,FBL,COMP,COCH,SURF1,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,EVA1B,COL4A5,PSMD7,DAPK2,DPM2,FNTA,MRPL38,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,PTRH1,SLC25A1,CDO1,IGF2R,MYO5A,LYN,SOX9,MXRA5,DEXI,LIG1,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,MAPK8IP2,RIMS4,H6PD,FIG4,RAB34,ERCC2,AKR1B10,AEBP2,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,LITAF,PC,BMP2,HABP4,ZFAND2A,ALDH2,DHCR7,EDN1,ERBB2,CRYM,THBS4,PATL1,NDUFV1,PKP1,RGS20,COL6A2,PACS1,G6PD,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,CERCAM,FCGBP,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,GSS,RAD23A,NR4A3,EVI5L,ITGA3,DMRT2,AHSA1,LGMN,IRX3,BAALC,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,NLRX1,ROR1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,CCT3,ALAS2,CAPRIN1,AKAP12,MAP7,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,RCOR2,ABCA5,CORO2B,THBS3,SF3B3,SDCCAG3,CELF1,STOM,CES1,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,NPTXR,ECM2,FUK,PLXNA1,RBBP9,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,NBEA,BRMS1,AXL,TRMT12,GBP4,OTUB1,RHBDD2,ANXA3,ATAD3A,TM4SF1,TFF3,FARP1,CD4,UNC5B,MAP1B,PIGQ,GUSB,NDUFB10,CAMK2D,SLC25A6,MYOM1,TTLL12,PLA2G5,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,FZD2,MRPS15,MFSD3,STX11,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,CYYR1,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,SLC2A10,KIAA0922,APBA3,CCDC184,PRSS23,RAP1GAP,N6AMT1,PEF1,C2orf40,CD14,CLCN7,XPNPEP1,CRABP2,DNPEP,ARL2,SPIRE1,AMY1C (includes others),--,SRM,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,GOT2,CHEK2,ADRB2,ZFP42,EMILIN1,BEX2,LXN,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,CIART,NAT8L,CYC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,WBSCR22,CTSG,COL8A1,PLEKHM2,CLIP1,FADS3,IQCC,MTHFD2,HIPK2,KAT2A,TMEM97,VPS4B,RNF121,TM6SF1,FAM189B,STK36,ANO6,MASP1,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,TMEM127,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,UBE2Z,ZBTB9,MMP25,G6PC3,MRPL22,GRINA,COL16A1,CS,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,FAM96B,TRIM29,POMGNT2,ALDH5A1,G3BP2,CNFN,ZNF524,PRDM11,GPM6B,CBR3,CYTH3,FOS,HP,LRRC75B,SLC22A18,ABCC3,RBP5,C11orf68,CH25H,ABCB6,MT2A,FOXRED1,TRAPPC2L,ATP13A1,ATP2B1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STARD7,STYXL1,HSPA5,AP2A2,CLPP,PADI4,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,HIF1AN,MRPS2,PPAN,PCMTD2,DOK5,RUNX1,UBXN1,TPR,COPE,STX6,ABCF1,NAT14,KIFC2,HNRNPK,GCDH,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,DECR2,MKL2,RNH1,LRPPRC,C10orf35,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,CES4A,IRF2BP2,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,CDC34,DNM1L,NREP,PARP6,CADM3,KCNK15,SLC29A4,DPYD,CAMK1,APOB,ITSN1,WDR45,DNAJB4,HRAS,PCOLCE,NEU1,MYRIP,PEG10,CCNB1IP1,ANK2,EXOC3,MATK,CACHD1,CALCRL,ITM2A,SLC24A3,TUBB2A,PLOD1,CRABP1,CTPS1,S1PR3,COLEC12,CCDC170,CDH2,CD68,PTPRB,NPRL3,CDRT1,SPINT2,MAP2K3,RAMP3,MAPK7,ZER1,SFRP1,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,ADAP2,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,EFNB2,ID1,SLC2A6,CMTM8,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,CTSK,VPS18,C5AR1,ADRM1,UBE2M,MGMT,DEFB1,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,DVL3,CBX4,FBN2,ADSSL1,ATP5D,SPHK2,HARS,IL17RC,UTP4,TPM1,TUBB,CCT8,PARVB,TNIP1,ITGA11,SDPR,GABARAPL1,BRSK1,PUSL1,NEO1,SLC7A5,PUF60,TRIM5,IGFBP6,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,GNL3,EXTL3,TMOD1,CUTA,VAPA,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TNFAIP3,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,NAA10,ACOT7,PRKCSH,COL1A2,SOX17,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,ALPL,STK40,HMGCS1,PI4KB,ASIP,PRNP,FAAH,CYP27A1,TRIP6,ZBTB7C,RAPGEF5,SLC7A8,COQ2,TBRG4,ZDHHC7,CCDC3,WARS,CYTIP,EDNRA,RTN3,PAQR7,TLE1,EEF1G,SLC39A8,PPRC1,TSC2,DEFB132,VIT,ECHDC1,WASH3P,DDIT4,SLX4,RANBP3,LARP4,PLAG1,DVL2,C14orf79,RAB40C,RCN3,KIAA1217,mir-21,FHL1,GBP1,TMEM79,MFSD5,SYNM,DIABLO,TIPARP,LLGL1,TRIT1,ATN1,EMP3,POLR1E,PSMB6,ID3,THNSL2,GPAM,SWAP70,MTHFSD,WDR86,GCSH,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DIRAS1,DNAJC15,INTS1,CBX5,TSPAN17,LHFPL2,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,RPL8,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,FEM1A,MRPL27,MRPL15,RPH3AL,ZNF252P,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,FRMD4A,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,EFEMP2,MAP4K4,C15orf59,RPLP0,ASPSCR1,SP110,PRG4,SPAG8,BIRC7,CDKN1C,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,MALSU1,CHI3L2,IRX5,APEH,FAHD2B,SH3GL1,CCDC136,MS4A14,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,CASP4,RNF185,CADM2,CCL8,ENTPD6,DIP2B,EGFL6,RNF135,HGS,RPS24,NAP1L4,SLC25A13,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,PQLC2,GPR180,FBXW9,WDR25,ZFYVE19,SPNS1,TBX15,SLC35F1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ETS2,ACP6,MCTP1,NAV1,PGP,AAGAB,FAM193A,FST,CD302,C5orf15,ACP2,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,NECAB2,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,LMAN2L,YIF1A,UVRAG,CDK5RAP2,UTP11,MAN1B1,SSU72,RAB5A,ARHGAP17,THBS1,ASAP3,TPST2,ATP2C1,PARP10,C9orf3,ANKRD54,TANC2,LRRK2,CCDC85A,C16orf58,ANO2,NCAPH2,RPS27L,FAM46A,MT1F,NCKAP1L,MYPOP,SLC47A1,MPV17,SLIT3,CSTA,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,TSPAN13,ASCC2,RNF125,SPI1,ATP2A2,MT1E,ODC1,CAAP1,NPL,NKAP,PPP1R3F,GATAD2A,NUP93,GPRC5C,EFHB,MYADM,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NSUN4,ALDOC,NUP43,PDIA5,ALDH1B1,SOGA1,MTSS1,LHPP,MFAP5,RAB3IL1,OSBPL10,RPAP3,REEP6,DCTD,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,PPP1R15A,ARHGEF6,PHF23,GCC1,TFRC,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,DEAF1,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,SCUBE2,HS2ST1,DUSP22,CTHRC1,CRAT,COPS8,TECR,ZNF285,KLHDC9,AHSA2,ASB1,DUSP5,POFUT2,CCL2,IRF2BPL,DAB2,ADORA1,HCAR2,CYP51A1,P4HA2,CCR1,SLC38A7,BTNL9,MED20,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,LY96,MYOC,ZFPM2,LDLR,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,IFFO2,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NCDN,NOC3L,TPPP3,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,CES2,BIN1,NNMT,TPRN,CXCL14,ZNF598,GYPE,STAB1,NBAS,PKP2,RILPL1,THRA,TRIM35,CDC42BPB,TLN2,MATN2,PLEKHF1,APCDD1,THAP7,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,FAM20B,SLC1A4,CDC20,SRPX,FRZB,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,GJA4,CCDC50,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,NUDT14,VWA5A,GTF2IRD1,NCOA7,CLCNKA,SPTLC2,SLC16A2,ALPK1,MRPL4,RIMS3,RPA1,GRAMD1A,UBQLN4,MRPL14,SRGAP3,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ALDH4A1,ATP5G1,RALA,TCTN1,RERGL,ACSF2,SCO1,FAXDC2,TMEM94,MTOR,TARS2,DHPS,ANXA5,SOCS2,EPS15L1,LIPG,LPP,SARS,COL18A1,NCKIPSD,PLAT,PTK7,C9orf142,GSTM1,CCDC130,RPL34,EPB41L4B,NR2C2AP,TRMT1,P4HTM,HGH1,MCM2,UQCR10,ZFP36L2,SCAMP3,C16orf89,MAPRE3,FZD7,MVD,NAGK,PTPN23,VPS28,XXYLT1,FNIP2,ARG2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,CLCN3,FAM65B,MYO10,AGBL5,DDX41,ADRA1B,MGRN1,C8orf46,APLNR,SPP1,NUP155,GPS2,ZNF408,MACROD1,PCSK7,MYOF,MARS,EIF2S2,RPL9,PANK1,CORO1B,R3HDM4,RRP7A,HSPA13,LSM7,AKR1B1,MAP2K5,RNPEP,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,ERN1,PCMT1,C1QTNF1,PNMAL1,FUBP3,RPS6KB2,HIST2H2AC,PSMA3,S100A8,MYO16,PRRT3,TMEM132B,SPOCD1,FRMD1,SMAD7,ENO1,LRP1B,OLFML2B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,ATG9A,BCAT2,PLXNB2,AMHR2,PTGIS,SLC2A5,HEYL,NDUFS7,ERICH1,KIAA0513,CTSB,TUFM,HSDL1,GADD45B,ABCC9,ZNF521,KIAA1549L,SPATS2L,GCNA,C1orf123,ARSD,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,TEF,LOX,IGFBP4,PLGRKT,INPPL1,COL6A6,PHLDB2,HLA-G,SNX16,ESPNL,GTPBP2,FARS2,SRC,KIF3B,POLR3B,PRUNE2,CMTM4,GYG2,SLC15A4,KIF21A,AFAP1,CMKLR1,RNASEH2A,NGRN,DPH2,CLEC4F,CCZ1/CCZ1B,EPB42,TBL3,ENAH,MCOLN1,LYZ,CLEC14A,CD24,ZFAND2B,MORN4,CEP164,CSRNP2,LRSAM1,CCDC8,SLIT2,TMEM42,EMC1,GABRE,DCAF13,IMMT,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,C8orf82,FAT1,TCEB2,METAP2,WDR5,GSPT1,BCL7C,ALDH3A2,PHPT1,ARL16,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,ACSL3,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,RARRES3,IDO1,GMPPB,SMAP1,SH3RF3,SLC4A11,WDR13,CD55,STK24,KCTD1,NCL,MAPKAPK2,CCDC189,ACADM,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,COLEC11,PLBD2,C2orf88,TMEM2,GLMP,ACAT1,GBE1,PDE8B,CPZ,C6,CLEC10A,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KEAP1,KIF1A,LUM,ST6GALNAC2,KANK3,CEP170B,MGP,CAV1,ATF4,STK32A,EBF2,CDC16,PIGT,SELE,PODN,PPP1R1B,TIMM8B,SMG5,FLOT1,THOP1,RHBDD1,BRF2,IFNAR2,TRAPPC3,ZNF579,CARD9,IFT122,NRDE2,CTSA,FBXW5,LRRN3,FSCN1,VARS2,TRPC4AP,NCF2,PRELP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,ADPGK,CXorf57,SAMD4A,ERI3,TOMM40,CHCHD10,FGF2,GUCD1,PHLDA2,SEMA6A,CCDC167,CKAP4,TOM1L2,SLC35B2,HS3ST3A1,LAMP3,TGM2,B4GALT7,ZMYND19,GADD45A,CHDH,FAM102A,RANGAP1,IL34,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,MAPKAP1,NINL,CUL7,MRPL12,TOB1,GFRA2,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,PLA2G4A,NRXN2,SNUPN,NR4A2,FLNC,FAM129A,GPBAR1,ATP1A2,MBD3,TMEM106C,TAF1C,XAF1,TMEM177,MAP3K8,AARS2,SEMA3C,CSTF3,QPCT,UQCC3,SESN2,SLC38A10,MBP,KLF6,C16orf91,MAP2K2,HDAC11,GCLM,CHTF18,CAST,DOK2,GM2A,SRPRB,ANO1,KLF4,SLC25A44,SLC3A2,ALG3,ARHGEF16,SLC25A39,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,DNAJB6,MEGF8,DOCK6,CADPS2,ATF6,RPL14,NET1,ENPP2,LONP1,C4orf3,ZNF358,SLC22A12,TUBG1,SMAD6,GATSL3,ASTN2,SMG7,RPS6KA4,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,FAM58A,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,WNT5B,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,TAF9B,CDH12,CCND2,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,MSC,ADAM17,GRB14,TCEA1,TTC1,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,STIM1,SH3GLB2,LBP,PRPF31,AMFR,SLC7A6,MYH1,SEMA3G,STK19,FMO3,ANGPT1,TWNK,IMPDH2,DPAGT1,MVB12A,HHATL,WARS2,B4GALT2,RHPN2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,CPSF3,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,XPO5,CXCL12,LIPE,SDC4,TAF10,PLEKHG4,CEL,CYP26B1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,PNMA2,AXIN2,DNASE2,ST6GALNAC3,LMCD1,C9orf9,ITGAM,ERCC1,SRPK3,PKD1,PLEKHH3,RNF165,NFIX,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,EPHB6,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NR2F6,HCST,CUL9,ACTN1,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,NEK11,EXOC4,DIP2C,LPAR1,ELK1	2108	
Cardiovascular System Development and Function, Organismal Development	angiogenesis	angiogenesis	3.34E-18	 	-1.401	 	-4.161	SLIT3,KCNJ2,COL8A1,SERPINA3,C1QA,IL6,ODC1,POR,GATAD2A,CTSH,CYBA,MGP,CAV1,HIPK2,ETS1,PTGIS,HEYL,SELE,COMP,C1GALT1C1,SMOC2,TMEM100,CDH5,CTSB,ALCAM,ITGA1,ADIPOR2,mir-21,APOE,DDIT3,GBP1,FGF2,CFC1/CFC1B,SEMA6A,ADIPOQ,COL15A1,TGM2,TIPARP,CCL2,GADD45A,SOS1,TNMD,DAB2,CYP51A1,HEY1,ZNF580,TJP1,CUL7,MESP1,IGF2R,ID3,GRN,FOS,PLA2G4A,HP,KIF7,ZFPM2,CBS/CBSL,SERPINH1,ATP6V0A2,PROCR,ARHGDIA,MAN2B1,BMPER,SEMA3C,BMP6,ISM1,SOCS3,ADGRA2,ITGB1BP1,KLF6,RGCC,TYMP,GPC3,MYC,TGFBR2,RHOB,GPR4,CXCL14,STAB1,PDCD6,GCLM,TEK,ELN,PFKFB3,CXCL8,NOX4,ATF3,ADAMTS1,MYDGF,STK39,LAMA2,BTG1,VEGFC,THRA,ADRA2A,ORM1,ALDH1A2,HIF1AN,IGFBP3,COMMD1,FZD5,MDK,MEGF8,ESR1,VHL,RUNX1,SULF1,LOX,IGFBP4,BMP2,ETV6,SHC1,DHCR7,EDN1,RGS5,TIMP1,MCAM,SAA1,MKL2,RNH1,ENPP2,ERBB2,AGT,GJA4,THBS4,SRC,VCAM1,AP1S2,SMAD6,G6PD,PLAUR,RCAN1,ADGRG1,CAPNS1,VAV3,CAT,SPARC,CXCL2,PNPLA6,CTGF,APOB,BMP4,TGFBR3,HRAS,NEU1,SGPL1,RARA,VEGFD,HEY2,PIK3C2B,ARHGEF4,CALCRL,ATG7,NDRG1,GUCY1A3,PCSK5,THY1,HBEGF,MMP2,JUNB,THBD,ROR1,S1PR3,CDH2,BSG,YARS,PTPRB,RTN4,ADM2,MAP2K3,LRP8,MAPK7,CYR61,ITGA7,NOTCH1,ANG,NRP1,COL3A1,ADM,LEPR,TNFSF10,MEOX2,COL5A1,EFNB2,ID1,MTOR,JUN,CST3,PDE3B,PRKCE,EGFL6,STIM1,COL18A1,SARS,NCKIPSD,PLOD3,PLAT,PTK7,GSTM1,C5AR1,ANGPT1,CSK,EGR1,SLIT2,BRMS1,AXL,CYP1B1,WARS2,F11R,TF,S100A9,PPP1R16B,SPRY2,ANXA3,S1PR1,PTGS2,CHD7,TM4SF1,CD36,UNC5B,SPHK2,CXCL12,SDC4,METAP2,RSPO3,ESAM,GSK3B,GPC1,LTBR,KLF2,FERMT3,PTX3,SPP1,EGR3,MYOF,FOXC1,STC1,ATPIF1,ITGAM,PKD1,PRKCD,AKR1B1,TMOD1,MAP2K5,AOC3,LEP,SFRP2,ERN1,SLC4A11,PKM,TNFAIP3,SMPD1,HIF1A,NGF,RAMP2,TNFRSF12A,COL1A2,SOX17,HMOX1,NFKBIA,ANGPTL4,CSPG4,THBS1,FLNA,KCNMA1,SRGN,SMO,CFB,KIT,CYGB,S100A8,SEMA3B,CHCHD4,NCL,MAPKAPK2,PTGER4,ADRB2,BEX2,EPAS1,CXCR4,SMAD7,HYAL1,CSF1R,EDF1,COL1A1,WARS,EPHB3,EDNRA,NDNF,C6,KDR,RCAN2,P2RX7,MMP9	295	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	neoplasia	Gastrointestinal Tract Cancer and Tumors	3.16E-17	 	0.453	 	1.306	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,DMAP1,RNPEPL1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,SLC1A5,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,VNN2,BIRC3,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,RRAS2,ACADVL,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,CTNS,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,NPRL2,PRPH,CD209,FCRLB,STAMBPL1,BLMH,COL12A1,EGR1,DAAM1,MED30,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,PTGES2,DHTKD1,CYP4X1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,COL1A1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,RAB38,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,APOE,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,DGAT2,OLFML3,FAM53B,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ISM1,BZW2,MEGF9,TMEM8A,NTMT1,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,TEX264,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,NAA60,NAALAD2,PRKCE,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,RAB34,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,PC,BMP2,ZFAND2A,ALDH2,EDN1,ERBB2,THBS4,PATL1,NDUFV1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,GSS,RAD23A,MIA,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,BAALC,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,SDCCAG3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,SLC48A1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,UNC5B,MAP1B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,STX11,HK1,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,KIAA0922,SLC2A10,APBA3,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,ZFP42,EMILIN1,BEX2,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,CTSH,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,GALM,FOS,TAGLN,NLE1,ABCC3,CH25H,ABCB6,MT2A,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STYXL1,AP2A2,CLPP,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,LAMA2,UNC13B,CAPG,PGAP3,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,STX6,ABCF1,CRYL1,KIFC2,GLRX,HNRNPK,GCDH,POLR1C,SHC1,MSRB3,DECR2,MKL2,RNH1,LRPPRC,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,DPYD,CAMK1,C1orf115,APOB,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,MATK,CACHD1,CALCRL,NDRG1,SLC24A3,TUBB2A,THY1,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,MAP2K3,RAMP3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,IDH1,FANCE,UCHL1,EFNB2,SLC2A6,STARD13,SNX10,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,TYROBP,MGMT,CYP1B1,KRT8,PLEKHG6,TF,CDK20,WAS,PPP1R16B,CNN1,ADCY1,ZSCAN18,S1PR1,MS4A2,NR5A2,DVL3,CBX4,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,ABL1,RBBP8,CDH23,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,COL1A2,SOX17,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,TRIP6,ZBTB7C,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,WARS,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,RBM38,DDIT4,SLX4,RANBP3,PLAG1,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,FRMD4A,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,MS4A14,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,CSTA,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,SOGA1,MTSS1,LHPP,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,GPX7,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,DUSP22,CTHRC1,CRAT,COPS8,TECR,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,P4HA2,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,LDLR,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,CES2,TPRN,CXCL14,ZNF598,GYPE,STAB1,NBAS,ATF3,PKP2,RILPL1,TRIM35,CDC42BPB,TLN2,MATN2,PLEKHF1,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,FAM20B,CDC20,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,SLC12A2,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,GTF2IRD1,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,EMILIN2,TCTN1,RERGL,ACSF2,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PLAT,PTK7,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,SERPINI1,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,AKR1B1,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,ERN1,C1QTNF1,PNMAL1,FUBP3,SRGN,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,PTGIS,HEYL,NDUFS7,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SOCS3,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,SNX16,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,LYZ,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,RARRES3,IDO1,GMPPB,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,C2orf88,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KIF1A,KEAP1,MGP,CEP170B,ST6GALNAC2,CAV1,ATF4,STK32A,EBF2,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,IFT122,NRDE2,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,ERI3,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,B4GALT7,ZMYND19,CHDH,FAM102A,PGA5 (includes others),IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,PLA2G4A,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,NET1,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,LBP,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,HHATL,WARS2,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,LIPE,SDC4,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,SLC22A5,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1836	
Cellular Movement	cell movement	cell movement of blood cells	3.27E-17	 	-0.106	 	-3.334	CTSG,SERPINA3,IL6,SPI1,EGR2,MYADM,LUM,CAV1,ETS1,TNFRSF21,SELE,COCH,ANO6,FLOT1,CARD9,PPP1R15A,ARHGEF6,CTSB,ALCAM,CD86,ITGA1,PLTP,PTPRA,APOE,DAPK2,FGF2,GNA11,GDF15,ACKR2,ADIPOQ,G6PC3,TGM2,CCL2,SOS1,PIK3R2,ADORA1,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,ZNF580,CD69,RGS16,PVR,GRN,GPR183,FOS,PLA2G4A,HP,LY96,SWAP70,LDLR,LYN,PROCR,MAP3K8,ST3GAL4,QPCT,SOCS3,RARRES2,HSPA1A/HSPA1B,FCER1A,GPC3,MYC,TGFBR2,RHOB,CXCL14,STAB1,CAST,VNN2,MARCO,RASGRP2,ELN,CXCL8,VEGFC,CAPG,PTGDS,GNAZ,ORMDL3,DUSP1,IGFBP3,MDK,ESR1,C2,TNFAIP8,RUNX1,LITAF,SFTPD,PLGRKT,ZP3,BMP2,CCL3,GLRX,ETV6,HLA-G,SHC1,EDN1,TIMP1,MCAM,SAA1,ENPP2,ERBB2,AGT,THBS4,SRC,VCAM1,NLRP3,MMP28,NQO1,ST3GAL6,PLAUR,TNFRSF14,BTK,CXCL16,RCAN1,VAV3,CAT,SPARC,CXCL2,CAMK1,APOB,BMP4,CTGF,ELANE,HRAS,MST1,POMC,HOXA9,SGPL1,ITGA3,RARA,ABCC1,VEGFD,TXN,CMKLR1,ATG7,NDRG1,PLEC,THY1,MMP2,THBD,NINJ1,S1PR3,DOCK1,AQP9,YARS,PIP5K1C,MS4A4A,IL10RA,RTN4,MAP2K3,MAPK7,SFRP1,CYR61,NOTCH1,ADM,CNN2,FYN,ADAM17,NQO2,HYOU1,TNFSF10,VCAN,EFNB2,LYZ,MTOR,CES1,JUN,GBA,CCL3L1,CCL8,CCL3L3,CST3,RHOD,CSF2RA,ANXA5,STIM1,LBP,RASSF5,GJB2,PLAT,IL11RA,CD209,CD276,C5AR1,ANGPT1,TYROBP,CSK,EGR1,HDC,DEFB1,SLIT2,CYP1B1,F11R,S100A9,WAS,PELI1,LSP1,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,TNFRSF4,PFN1,ADRBK1,LAMTOR2,CD36,CD4,UNC5B,SPHK2,CXCL12,HARS,CYP26B1,RSPO3,ESAM,NARS,IKBKG,PLA2G5,NEO1,LTBR,C1QBP,FAM65B,KLF2,FERMT3,PTX3,CSF3R,MIF,SPP1,TPSAB1/TPSB2,APBA3,STC1,EFS,ITGAM,RAP1GAP,PRKCD,CD14,IDO1,CCL18,AKR1B1,AOC3,LEP,PA2G4,ABL1,TNFAIP3,SMPD1,MYLK,GPR34,IRF3,HIF1A,NGF,HMOX1,CD55,NFKBIA,CCL13,THBS1,FLNA,DUSP10,CFB,KIT,S100A8,MAPKAPK2,ADRB2,PRNP,EPAS1,CXCR4,PCOLCE2,SMAD7,HYAL1,LRRK2,F13A1,NFKBIZ,CSF1R,COL1A1,CYTIP,EDNRA,C6,KDR,NCKAP1L,P2RX7,MMP9	281	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	mammary tumor	mammary tumor	4.34E-17	 	-0.489	 	-1.023	PAQR7,TLE1,IL6,POR,CCND3,EIF3B,AJUBA,CSE1L,PPRC1,MAP1A,AMHR2,ETS1,HEYL,SRPRA,DDIT4,PTOV1,CDH5,SLC27A1,RAB40C,mir-21,FTH1,EIF3K,EPHX1,LTBP2,GADD45B,ADIPOQ,RABL6,GTF3C1,MECOM,EMP3,CD69,IGF2R,PAMR1,GPR183,PDZD2,AFF3,LYN,SOX9,AKR1C3,TRPM8,FCER1A,GPC3,CTSD,CARD8,NDUFA10,TUBA1C,TEK,CXCL8,H19,ADAMTS1,GNAZ,ERCC2,BCL2L1,H3F3A/H3F3B,ADRA2A,BAP1,C17orf97,VHL,RAB11FIP5,SULF1,MRPL15,ZP3,PLGRKT,RPH3AL,BMP2,INPPL1,COL6A6,HLA-G,ALDH2,EDN1,F8,IGSF8,ERBB2,PATL1,SRC,MMP28,FRMD4A,BTK,RRAS2,ACADVL,SPARC,AP3M2,COL11A1,ING1,CXCL2,FCGBP,KCND2,EIF3C,DDX11,CTGF,BMP4,TYRO3,GYG2,ACP5,NR4A3,ITGA3,PRG4,IRX3,RARA,LYVE1,MCL1,PIK3C2B,MT1X,PLEC,FAHD2A,HBEGF,JUNB,PARP3,RNASEH2A,NLRX1,FAHD2B,FARSA,MAP3K12,DPH2,EEF2KMT,C19orf53,PDE1B,RTN4,CCT3,NOTCH1,ANG,SORL1,AKAP12,SQLE,FYN,ZFP36,GSTM5,LEPR,CRTAP,HEATR1,NQO2,FKBP1A,ATAT1,FAM174B,H2AFZ,SF3B3,EIF4EBP1,C20orf96,ENAH,NDUFB9,CES1,JUN,ZNF334,CSF2RA,ZNF608,TUB,CD24,EGFL6,FUK,AHNAK2,GJB2,LIMCH1,RPS24,NAP1L4,CD276,CEP164,STAMBPL1,EGR1,WDR55,COL12A1,SLIT2,RELN,AXL,COPS3,PLA2G2A,ANXA3,PTGS2,FBXW9,MAMSTR,TM4SF1,COBLL1,PFN1,FAT1,CD4,LHCGR,METAP2,WDR5,H2AFY2,GSPT1,CNDP2,ALDH1A1,SLC25A6,ETS2,COMT,BCL7C,AMPH,GSK3B,C1QBP,RET,MT1G,PTPRE,GSDMB,EGR3,LAGE3,PAWR,PCDHA1,ANKRD33,ZNHIT1,SORD,SCRIB,LMAN2L,CRABP2,SFRP2,HIGD1A,ATF5,NGF,PTPRF,NELFE,NFKBIA,ARHGAP17,THBS1,NCL,MAPKAPK2,CHEK2,ADRB2,BEX2,TPST2,ATP2C1,C9orf3,LRRK2,CCDC85A,DHX37,THRSP,PRMT1,COL1A1,PLEKHH1,CYC1,PLP2,MT1F,GPR160,C6,KDR,CLEC10A,HCAR3,SYTL2,CACNA1H,COL8A1,SPI1,MT1E,CLIP1,ODC1,ZNF263,IP6K3,NUP93,CYBA,IQCC,KEAP1,CAV1,ATF4,TSHZ2,MRPL24,ALDOC,PIGT,PDIA5,SELE,SOGA1,TIMM44,PPP1R1B,TNFRSF10B,SMG5,MASP1,LAMC3,BRF2,MAMDC2,GPX7,HAX1,SHROOM4,NRBP1,TNPO2,CTSA,FSCN1,BTG2,SAMD4A,PTPRA,APOE,NME1,FGF2,SCUBE2,CEBPD,CDK4,CTDSPL,MMP25,KLHDC9,COL16A1,PNPO,CCL2,GADD45A,PLIN2,NOL12,DAB2,FAM96B,ADORA1,HCAR2,TBC1D10B,RAD21,MRPL12,NLGN4X,C1orf122,CBR3,FAM178B,FOS,ARHGEF5,HP,NRXN2,NR4A2,NTRK3,TAGLN,TMEM106C,SLC22A18,ARHGDIA,C19orf12,TP53BP1,MAP3K8,PIN1,CPXM1,HAGH,ISM1,MT2A,PTTG1,PARP2,KLF6,TYMP,STYXL1,HSPA5,BIN1,MYC,TGFBR2,ADGRF5,GSTM2,RHOB,GPR4,MAP2K2,HDAC11,CXCL14,FAR2,PDCD6,PFKFB3,ATF3,IER2,MAST4,VEGFC,PGAP3,DCHS1,KLF4,ELOVL6,FOSB,ABCA8,ORM1,DUSP1,GIPC1,LIMA1,IGFBP3,DNAJB6,MEGF8,ESR1,DPH5,PMEPA1,RUNX1,CDC20,FRZB,MECR,ABCF1,CCL3,REXO2,SHC1,TIMP1,MCAM,MKL2,LOC102724428/SIK1,MCRS1,LONP1,AGT,PARVA,C4BPB,TUBG1,UPP1,NQO1,BSCL2,PNCK,NFE2L1,SH3PXD2A,XYLT2,CLGN,TACC2,VAV3,CAT,NOP16,ALKBH3,DPYD,APOB,ITSN1,TGFBR3,HRAS,CDKN2C,VWA5A,PCOLCE,NEU1,SLC4A3,PEX16,CLCNKA,ABR,ABCC1,ZHX2,ANK2,VEGFD,IRS2,HEY2,WNT5B,FANCG,GSTM3,TUBB2A,MMP2,IER3,TNK2,UBQLN4,COLEC12,CDH2,SRGAP3,TIMP4,ASGR1,CCND2,CD68,BSG,MS4A4A,STIP1,MAP3K20,ADAMTS18,ALDOA,TRO,GLUL,RPL6,MAP2K3,HSPB7,MAPK7,SFRP1,AIDA,CYR61,MYEOV,HIST1H1C,ADAM17,PIGO,GRB14,NID2,UHRF1BP1,TNFSF10,XPOT,PFKL,MYH11,DCLK1,TAX1BP3,VCAN,TMEM94,IDH1,FANCE,UCHL1,COL5A1,TRIB1,ID1,MTOR,GBA,ALDH1A3,CLMN,SH3GLB2,TPO,PCBP2,PLOD3,PLAT,MYCN,SOX7,GSTM1,ADRM1,DPAGT1,RRP12,POLD1,YBX2,F11R,COL5A3,SUPV3L1,KRT8,MCM2,S100A9,CDK20,IPO13,CNN1,PELI1,LSP1,DVL3,CBX4,ZFP36L2,NEDD9,MAPRE3,CYP2C8,FBN2,RGS1,PLA2G15,CXCL12,UTP4,TPM1,TUBB,COBL,CCNL1,MTCH2,ASXL2,BRSK1,EIF5,KPNA2,SIAH2,MYO10,AGBL5,ACTA1,PDK4,EIF2AK1,CSF3R,IGFBP6,MIF,AXIN2,SPP1,PCSK7,LMNA,MARS,PKN1,PPP2R1A,SMOX,AKR1B1,AOC3,ADAMTS7,LEP,PRDX5,FLRT2,BCL2L12,PKM,ABL1,RBBP8,PPP1CB,SLC7A1,TET1,TNFAIP3,MYLK,GPR34,ITGA10,SIL1,HIF1A,COL1A2,EPHB6,HMOX1,AEBP1,CSPG4,FLNA,CLOCK,KIT,ARHGEF2,NEK7,S100A8,CUL9,ALPL,HMGCS1,PI4KB,PTGER4,NDUFAF3,TAF6,CXCR4,VWCE,SMAD7,QSOX1,ZBTB7C,CSF1R,ENO1,DIP2C,LPAR1,EXOC4,RDH5,UBA1,MMP9,SHMT2	574	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function	proliferation	proliferation of fibroblast cell lines	4.89E-17	 	0.617	 	-1.168	EIF3C,ASPSCR1,BMP4,ITSN1,AXIN1,HRAS,IL6,EIF6,ODC1,MIA,BOP1,EGR2,EIF3B,ATG9A,SMARCB1,TSC2,CAV1,CSTF2,HIPK2,MAD2L2,HBEGF,GRK5,HMGA1,IER3,JUNB,PLAG1,S1PR3,SH3GL1,PIP5K1C,STIP1,PPP1R15A,BTG2,PSMA4,ALDOA,TFRC,MAP2K3,EBNA1BP2,CAPRIN1,PDGFD,NOTCH1,AKAP12,RALA,GRB14,GADD45B,FGF2,BTG3,TTLL4,CDK4,ADIPOQ,VCAN,DDX3X,TGM2,ID1,GADD45GIP1,JUN,GADD45A,CSF2RA,SOS1,RHOU,PRKCE,RASSF5,LDLRAP1,CSNK2B,MYCN,EGR1,CUL7,TOB1,GRN,FOS,SWAP70,NTRK3,SBF1,SOX9,CBX4,PPIL1,ADRA1A,LIG1,NOC3L,PRPF19,TFG,PTTG1,HSPA1A/HSPA1B,KLF6,SPHK2,CXCL12,TPM1,CES2,SDC4,MYC,CTSD,PLCE1,RHOB,ITGA11,CXCL14,CAST,RET,KLF2,ADRA1B,RASGRP2,EIF2AK1,PFKFB3,NOX4,MIF,BTG1,LMNA,SLC3A2,BCL2L1,PKD1,PRKCD,IGFBP3,MDK,AKR1B1,S100P,RUNX1,LOX,LEP,BMP2,TPR,PKM,IRF3,NGF,CDKN2B,ETV6,HDGF,HMOX1,HINT1,NFKBIA,STUB1,THBS1,KIT,CYGB,CDCA5,ERBB2,CIZ1,MCRS1,MAPKAPK2,SRC,PAK4,TAF6,G6PD,PLAUR,ZBTB7C,SERTAD1,CSF1R,ATIC,PRMT1,COL1A1,LPAR1,CAT,ACAT1,ING1,NREP	152	
Cellular Movement, Immune Cell Trafficking	migration	leukocyte migration	6.51E-17	 	-0.126	 	-3.336	CTSG,SERPINA3,IL6,SPI1,EGR2,MYADM,LUM,CAV1,ETS1,TNFRSF21,SELE,COCH,ANO6,FLOT1,CARD9,PPP1R15A,ARHGEF6,CTSB,ALCAM,CD86,ITGA1,PLTP,PTPRA,APOE,DAPK2,FGF2,GNA11,GDF15,ACKR2,ADIPOQ,G6PC3,TGM2,CCL2,SOS1,PIK3R2,ADORA1,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,ZNF580,CD69,RGS16,PVR,GRN,GPR183,FOS,PLA2G4A,HP,LY96,SWAP70,LDLR,LYN,PROCR,MAP3K8,ST3GAL4,QPCT,SOCS3,RARRES2,HSPA1A/HSPA1B,FCER1A,GPC3,MYC,TGFBR2,RHOB,CXCL14,STAB1,CAST,VNN2,MARCO,RASGRP2,ELN,CXCL8,VEGFC,CAPG,PTGDS,GNAZ,ORMDL3,DUSP1,IGFBP3,MDK,ESR1,C2,TNFAIP8,RUNX1,LITAF,SFTPD,PLGRKT,ZP3,BMP2,CCL3,GLRX,ETV6,HLA-G,SHC1,EDN1,TIMP1,MCAM,SAA1,ENPP2,ERBB2,AGT,THBS4,SRC,VCAM1,NLRP3,MMP28,NQO1,ST3GAL6,PLAUR,TNFRSF14,BTK,CXCL16,RCAN1,VAV3,CAT,SPARC,CXCL2,CAMK1,APOB,CTGF,ELANE,HRAS,MST1,POMC,HOXA9,SGPL1,ITGA3,RARA,ABCC1,VEGFD,TXN,CMKLR1,ATG7,NDRG1,PLEC,THY1,MMP2,THBD,NINJ1,S1PR3,DOCK1,AQP9,YARS,PIP5K1C,MS4A4A,IL10RA,RTN4,MAP2K3,MAPK7,SFRP1,CYR61,NOTCH1,ADM,CNN2,FYN,ADAM17,NQO2,HYOU1,TNFSF10,VCAN,EFNB2,LYZ,MTOR,CES1,JUN,GBA,CCL3L1,CCL8,CCL3L3,CST3,RHOD,CSF2RA,ANXA5,STIM1,LBP,RASSF5,GJB2,PLAT,IL11RA,CD209,CD276,C5AR1,ANGPT1,TYROBP,CSK,EGR1,HDC,DEFB1,SLIT2,CYP1B1,F11R,S100A9,WAS,PELI1,LSP1,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,TNFRSF4,PFN1,ADRBK1,LAMTOR2,CD36,CD4,UNC5B,SPHK2,CXCL12,HARS,CYP26B1,RSPO3,ESAM,NARS,IKBKG,PLA2G5,NEO1,LTBR,C1QBP,FAM65B,KLF2,FERMT3,PTX3,CSF3R,MIF,SPP1,TPSAB1/TPSB2,APBA3,STC1,EFS,ITGAM,RAP1GAP,PRKCD,CD14,IDO1,CCL18,AOC3,LEP,PA2G4,ABL1,TNFAIP3,SMPD1,MYLK,GPR34,IRF3,HIF1A,NGF,HMOX1,CD55,NFKBIA,CCL13,THBS1,FLNA,DUSP10,CFB,KIT,S100A8,MAPKAPK2,ADRB2,PRNP,EPAS1,CXCR4,PCOLCE2,SMAD7,HYAL1,LRRK2,F13A1,NFKBIZ,CSF1R,COL1A1,CYTIP,EDNRA,C6,KDR,NCKAP1L,P2RX7,MMP9	279	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast or ovarian cancer	breast or ovarian cancer	2.44E-16	 	-0.303	 	-0.462	PCLO,VAC14,PAQR7,POR,AJUBA,PPRC1,ETS1,DDIT4,SRPRA,SLX4,CDH5,C14orf79,ALCAM,SLC27A1,RAB40C,mir-21,LTBP2,SYNM,RABL6,TIPARP,EMP3,PAMR1,GPR183,PDZD2,AFF3,KIF7,SWAP70,TBC1D8,WBP2,AKR1C3,TRPM8,RGCC,CARD8,NDUFA10,TUBA1C,TEK,ADAMTS1,GNAZ,BCL2L1,CRHBP,H3F3A/H3F3B,C17orf97,RAB11FIP5,FEM1A,RPH3AL,ZP3,MRPL15,CLUAP1,F8,IGSF8,NLRP3,MMP28,PLAUR,FRMD4A,RRAS2,ACADVL,ANO3,SPARC,AP3M2,ING1,CXCL2,ASPSCR1,EIF3C,CTGF,GMDS,PRG4,LYVE1,MCL1,PIK3C2B,MT1X,PLEC,HBEGF,FAHD2A,TMEM267,HMGA1,PARP3,CREB5,FAHD2B,SH3GL1,MAP3K12,ACAD11,MS4A14,EEF2KMT,NCLN,NOTCH1,COL3A1,NRP1,SORL1,ZFP36,RP9,NQO2,SIN3B,FKBP1A,H2AFZ,ZNF608,ENTPD6,DIP2B,COL22A1,TUB,EGFL6,AHNAK2,LIMCH1,GJB2,RPS24,NAP1L4,CD276,STAMBPL1,COL12A1,EGR1,NTM,RELN,COPS3,DHCR24,PTGS2,FBXW9,ZFYVE19,COBLL1,LHCGR,CLEC3B,CLIP3,FAM173A,H2AFY2,CNDP2,ETS2,COMT,DHTKD1,MCTP1,PGP,EGR3,LAGE3,PAWR,SORD,COL6A3,SCRIB,LMAN2L,HIGD1A,PTPRF,SSU72,ARHGAP17,THBS1,TMEM104,TPST2,ATP2C1,C9orf3,LRRK2,TANC2,CCDC85A,THRSP,COL1A1,PLEKHH1,PLP2,MT1F,NIPA2,HCAR3,SYTL2,MAP6,CACNA1H,SPI1,ODC1,MT1E,OGFOD3,NUP93,CYBA,ARHGAP39,SPATA18,ALDH3A1,TSHZ2,MRPL24,ALDOC,PDIA5,TIMM44,SOGA1,MFAP5,TNFRSF10B,LAMC3,GPX7,HAX1,NRBP1,TNPO2,IGSF10,APOE,NME1,FBXO10,NACC2,CUBN,GDF15,SCUBE2,CDK4,CEBPD,CTDSPL,KLHDC9,IFI27,DUSP5,CCL2,PNPO,PLIN2,DAB2,ADORA1,HCAR2,RAD21,MED20,NLGN4X,C1orf122,FAM178B,ARHGEF5,ZFPM2,LDLR,NTRK3,ARHGDIA,PIN1,CPXM1,HAGH,ISM1,ABCA3,TYMP,CES2,MYC,TGFBR2,GPX3,ADGRF5,RHOB,CXCL14,STAB1,PDCD6,LILRB5,FMO4,PFKFB3,ATF3,PKP2,VEGFC,DCHS1,FOSB,TLN2,ABCA8,GIPC1,APCDD1,ALDH1A2,ESR1,LRRC47,DPH5,S100P,PMEPA1,MAST2,ERAP2,FAM107A,FRZB,CDC20,MECR,ZSWIM3,RAP1GDS1,TIMP1,MCAM,LOC102724428/SIK1,VARS,NUSAP1,PARVA,VCAM1,UPP1,BSCL2,PNCK,ATIC,NFE2L1,SH3PXD2A,XYLT2,CLGN,VAV3,CAT,LPAR5,CDKN2C,VWA5A,GTF2IRD1,HOXA9,SLC4A3,CLCNKA,ABR,ABCC1,ZHX2,CSTF2,VEGFD,HEY2,FANCG,GSTM3,MMP2,IER3,RAD51D,UBQLN4,RAE1,SRGAP3,MS4A4A,MAP3K20,MS4A7,TRO,ALDOA,RPL6,LRP8,HSPB7,AIDA,HIST2H2AA3/HIST2H2AA4,CHCHD6,PFKL,KHDC1,VCAN,TAX1BP3,TMEM94,TRIB1,MTOR,ALDH1A3,TBCD,COL18A1,PLOD3,PLAT,CYP11A1,GSTM1,SOX7,RRP12,POLD1,F11R,COL5A3,PELI1,PEA15,ZFP36L2,MAPRE3,CYP2C8,PLA2G15,ARG2,COBL,CCNL1,KPNA2,SIAH2,MYO10,AGBL5,ACTA1,CSF3R,SPP1,LMNA,MYOF,MARS,THSD7B,AKR1B1,RNPEP,COL7A1,AOC3,ADAMTS7,LEP,PRDX5,FLRT2,BCL2L12,FLNA,FUBP3,HIST2H2AC,S100A8,RNF144B,PRRT3,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,VWCE,SMAD7,CSF1R,ENO1,ITPA,UBA1,RDH5,MMP9,ATP6V1B2,SHMT2,IL6,NPAS2,EIF3B,CCND3,CSE1L,MAP1A,AMHR2,FBL,PTGIS,HEYL,PTOV1,EPHX1,EIF3K,FTH1,GADD45B,COL15A1,DDX3X,DTNA,GTF3C1,MECOM,KIAA1549L,CD69,CDO1,IGF2R,SOX9,LIG1,MICALL2,FCER1A,AP1B1,GPC3,CTSD,CCT5,CXCL8,H19,TJP2,ERCC2,TXNRD1,BAP1,VHL,SLC11A1,IGFBP4,SULF1,PLGRKT,INPPL1,COL6A6,PHLDB2,HLA-G,ALDH2,EDN1,ERBB2,PATL1,SRC,COL11A1,FCGBP,CERCAM,KCND2,DDX11,BMP4,CMTM4,TYRO3,PCDH17,GYG2,POMC,ACP5,NR4A3,ITGA3,EVI5L,IRX3,RARA,MGAT4B,EFL1,CMKLR1,CAPN6,ATP8B4,JUNB,RNASEH2A,NLRX1,FARSA,DPH2,C19orf53,PDE1B,RTN4,CCT3,ANG,AKAP12,FYN,SQLE,GSTM5,HEATR1,CRTAP,FAM174B,ATAT1,SF3B3,THBS3,CORO2B,ENAH,EIF4EBP1,C20orf96,NDUFB9,STOM,JUN,KAT2B,CES1,PDE3B,CSF2RA,ZNF334,CD24,NPTXR,FUK,PLXNA1,CEP164,MYOM2,WDR55,LRSAM1,NBEA,SLIT2,AXL,PLA2G2A,ANXA3,ATAD3A,MAMSTR,TM4SF1,LRFN4,TFF3,PFN1,FARP1,FAT1,CD4,METAP2,WDR5,GSPT1,ALDH1A1,SLC25A6,BCL7C,AMPH,C1QBP,GSK3B,RET,HK1,KLHDC3,MT1G,PTPRE,GSDMB,PCDHA1,MAPK8IP3,ZNHIT1,ANKRD33,IDO1,CRABP2,SFRP2,ATF5,SLC4A11,HSPE1,CFB,NCL,GOT2,MAPKAPK2,CHEK2,ADRB2,BEX2,EPAS1,DHX37,CIART,C2orf88,CYC1,EPHB3,GPR160,C6,KDR,CLEC10A,COL8A1,CLIP1,FADS3,ZNF263,IP6K3,EGR2,IQCC,KEAP1,MGP,KANK3,CAV1,MTHFD2,ATF4,RNF121,PIGT,SELE,PPP1R1B,MASP1,SMG5,FLOT1,BRF2,MAMDC2,TFPI2,SHROOM4,TMEM127,NRDE2,CTSA,EVPL,VARS2,FSCN1,BTG2,GAPDH,ITGA1,SAMD4A,FGF2,MMP25,TGM2,COL16A1,CS,SORBS1,NOL12,FAM96B,TBC1D10B,NINL,MRPL12,CUL7,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,NRXN2,NR4A2,TMEM106C,TAGLN,SLC22A18,C19orf12,MAP3K8,SEMA3C,ABCC3,MT2A,ATP13A1,PTTG1,KLF6,PARP2,STYXL1,STARD7,GSTM2,GPR4,MAP2K2,HDAC11,FAR2,CAST,MAST4,IER2,GM2A,LAMA2,PGAP3,KLF4,ELOVL6,ORM1,DUSP1,LIMA1,IGFBP3,DNAJB6,MEGF8,RUNX1,TPR,ABCF1,CCL3,REXO2,GCDH,SHC1,MSRB3,POLR1C,MKL2,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,C4BPB,NQO1,TUBG1,EMD,GATSL3,LARP6,CXCL16,PMP22,TACC2,NOP16,ALKBH3,APOB,DPYD,ITSN1,TGFBR3,HRAS,RAPH1,PCOLCE,NEU1,PEX16,ANK2,IRS2,EYA2,WNT5B,RRBP1,TUBB2A,TNK2,CDH2,COLEC12,TIMP4,CCND2,ASGR1,BSG,CD68,ADAMTS18,GLUL,SPINT2,MAP2K3,SFRP1,ZER1,MAPK7,CYR61,MYEOV,SPTBN1,HIST1H1C,ADAM17,GRB14,PIGO,NID2,WASF3,UHRF1BP1,XPOT,TNFSF10,TTC1,MYH11,DCLK1,IDH1,COL5A1,FANCE,EFNB2,GBA,CMTM8,CLMN,TPO,SH3GLB2,PCBP2,PTPRT,MYCN,VPS18,ADRM1,ANGPT1,MGMT,DPAGT1,MVB12A,YBX2,KRT8,S100A9,TF,PLEKHG6,IPO13,CDK20,CNN1,LSP1,MS4A2,CBX4,DVL3,FBN2,PHLDA1,RGS1,SPHK2,CXCL12,XPO5,TPM1,UTP4,TUBB,MTCH2,ASXL2,BRSK1,EIF5,PDK4,EIF2AK1,IGFBP6,AXIN2,MIF,PKN1,STC1,PPP2R1A,ERCC1,PKD1,SMOX,EPB41L3,CUTA,PKM,RBBP8,ABL1,TNFAIP3,TET1,SLC7A1,MYLK,HIF1A,SIL1,ITGA10,CDKN2B,FAM110B,EPHB6,COL1A2,EVC,HMOX1,AEBP1,PCK2,CSPG4,CLOCK,KIT,NEK7,ARHGEF2,HMGCS1,STK40,ALPL,CUL9,PI4KB,NDUFAF3,TAF6,CXCR4,QSOX1,ZBTB7C,DIP2C,LPAR1,EXOC4,RTN3	789	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	gastrointestinal tract cancer	gastrointestinal tract cancer	5.23E-16	 	1.295	 	1.776	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,DMAP1,RNPEPL1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,SLC1A5,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,VNN2,BIRC3,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,KCNS3,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,RRAS2,ACADVL,ANO3,ORM2,AP3M2,ING1,CXCL2,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,NPRL2,PRPH,CD209,FCRLB,STAMBPL1,BLMH,COL12A1,EGR1,DAAM1,MED30,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,PTGES2,DHTKD1,CYP4X1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,INHBB,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ICK,ZNF174,PTPRF,RGS17,MAN2C1,HINT1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,COL1A1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,CCDC88C,ANKRD20A4 (includes others),SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,RAB38,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,APOE,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,OLFML3,FAM53B,MRPS25,UBL7,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,PPIL1,ISM1,BZW2,MEGF9,TMEM8A,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,MDK,ESR1,LRRC47,S100P,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,PRKCE,NAA60,NAALAD2,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,ADRBK1,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTPN3,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,FTH1,EIF3K,EPHX1,CD163L1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,DDX3X,SPON1,DTNA,PEPD,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,CSTB,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,RAB34,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,GSDMC,SYN1,SLC11A1,VHL,SULF1,PC,BMP2,ALDH2,ZFAND2A,EDN1,ERBB2,THBS4,PATL1,NDUFV1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,SERTAD1,APOLD1,ITM2C,COL11A1,KCND2,DDX11,BMP4,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,GSS,RAD23A,MIA,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,BAALC,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,FAM71E1,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,SDCCAG3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,UNC5B,MAP1B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,AMPH,GSK3B,GPC1,RET,HLA-F,STX11,HK1,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,KIAA0922,SLC2A10,APBA3,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,PA2G4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,ZFP42,EMILIN1,BEX2,PAK4,EPAS1,SNRPB,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,CTSH,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,TFPI2,MAMDC2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,FOS,TAGLN,NLE1,ABCC3,CH25H,ABCB6,MT2A,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,PTTG1,SLF2,PARP2,DPP7,POLR3E,OGFOD1,STYXL1,AP2A2,CLPP,GPR4,KCNAB1,TMEM8B,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,CLIP2,UNC13B,LAMA2,PGAP3,CAPG,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,STX6,ABCF1,CRYL1,KIFC2,GLRX,HNRNPK,GCDH,POLR1C,SHC1,MSRB3,DECR2,MKL2,RNH1,LRPPRC,TOX2,AGT,SUGP2,PWWP2B,NQO1,TUBGCP2,LARP6,NUP210L,ANGPTL5,CIDEA,PMP22,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,DPYD,CAMK1,C1orf115,APOB,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,MATK,CACHD1,CALCRL,NDRG1,SLC24A3,TUBB2A,THY1,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,RAMP3,MAP2K3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,IDH1,UCHL1,FANCE,EFNB2,SLC2A6,STARD13,SNX10,KIAA0391,LDLRAP1,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,TYROBP,MGMT,CYP1B1,KRT8,PLEKHG6,TF,CDK20,PPP1R16B,WAS,CNN1,ZSCAN18,ADCY1,MS4A2,S1PR1,NR5A2,CBX4,DVL3,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,ABL1,RBBP8,CDH23,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,COL1A2,SOX17,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,TRIP6,ZBTB7C,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,WARS,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,POR,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,RANBP3,PLAG1,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,SNTB1,PLAUR,FRMD4A,VAT1,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,MS4A14,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,CSTA,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,SOGA1,MTSS1,LHPP,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,DUSP22,CTHRC1,CRAT,COPS8,TECR,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,P4HA2,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,LDLR,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,TPRN,CXCL14,ZNF598,GYPE,STAB1,NBAS,ATF3,PKP2,RILPL1,TRIM35,CDC42BPB,TLN2,MATN2,PLEKHF1,VPS37A,CCPG1,C2,MAST2,PTGFR,ERAP2,FAM107A,FAM20B,CDC20,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,VPS4A,SLC2A3,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,TIMP1,OLFML2A,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,EMILIN2,TCTN1,RERGL,ACSF2,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PLAT,PTK7,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,F11R,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,SERPINI1,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,TMED5,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,ERN1,C1QTNF1,PNMAL1,FUBP3,SRGN,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,PTGIS,HEYL,NDUFS7,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,ARHGAP20,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,SNX16,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,LYZ,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,RARRES3,IDO1,GMPPB,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,ASCC1,C1QC,SLC9A1,ADCK1,NSF,ZNF263,EGR2,KIF1A,KEAP1,MGP,CEP170B,ST6GALNAC2,CAV1,ATF4,EBF2,STK32A,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,IFT122,NRDE2,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,ERI3,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,B4GALT7,ZMYND19,CHDH,FAM102A,PGA5 (includes others),IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,DUSP1,ARHGEF16,SLC25A39,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,NET1,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,BSG,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,RSU1,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,LBP,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,HHATL,WARS2,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,LIPE,SDC4,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,CXCR4,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1814	
Cardiovascular System Development and Function, Cellular Movement	cell movement	cell movement of endothelial cells	8.05E-16	 	-0.961	 	-3.409	SLIT3,BMP4,CTGF,HRAS,HOXA9,NEU1,ITGA3,MGP,CAV1,VEGFD,ETS1,SFRP4,PIK3C2B,ARHGEF4,SELE,MTSS1,THY1,MMP2,THBD,S1PR3,CDH2,CDH5,ARHGEF6,RTN4,ALCAM,MAP2K3,CYR61,mir-21,NRP1,ADM,CNN2,APOE,FGF2,GNA11,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,CCL2,GADD45A,STARD13,PRKCE,CSNK2B,COL18A1,HEY1,PLXNA1,ANGPT1,TJP1,ZNF580,SLIT2,AXL,ID3,IGF2R,CYP1B1,GRN,F11R,PLA2G4A,CBS/CBSL,ANXA3,S1PR1,PTGS2,BMP6,ADGRA2,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,HSPA5,MYC,TGFBR2,ESAM,RHOB,OSR1,CXCL14,STAB1,PDCD6,GSK3B,GPC1,KLF2,TEK,ELN,CXCL8,NOX4,MIF,SPP1,ADAMTS1,VEGFC,THRA,TARS,FOXC1,STC1,ORM1,GIPC1,IGFBP3,MDK,MAP2K5,S100P,LOX,LEP,BMP2,PKM,HIF1A,TNFRSF12A,ANGPTL4,EDN1,TIMP1,FLNA,THBS1,CSPG4,MCAM,SAA1,ENPP2,ERBB2,NCL,MAPKAPK2,AGT,SRC,VCAM1,CXCR4,G6PD,PLAUR,WARS,VAV3,SPARC,KDR,MMP9	129	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast cancer	breast cancer	8.71E-16	 	-0.303	 	-0.561	PAQR7,IL6,POR,CCND3,EIF3B,AJUBA,CSE1L,PPRC1,MAP1A,AMHR2,ETS1,HEYL,SRPRA,DDIT4,PTOV1,CDH5,SLC27A1,RAB40C,mir-21,FTH1,EIF3K,EPHX1,LTBP2,GADD45B,RABL6,GTF3C1,MECOM,EMP3,CD69,IGF2R,PAMR1,GPR183,PDZD2,AFF3,SOX9,AKR1C3,TRPM8,FCER1A,GPC3,CTSD,CARD8,NDUFA10,TUBA1C,TEK,CXCL8,H19,ADAMTS1,GNAZ,ERCC2,BCL2L1,H3F3A/H3F3B,BAP1,C17orf97,VHL,RAB11FIP5,SULF1,MRPL15,PLGRKT,RPH3AL,ZP3,INPPL1,COL6A6,HLA-G,ALDH2,EDN1,F8,IGSF8,ERBB2,PATL1,SRC,MMP28,FRMD4A,RRAS2,ACADVL,SPARC,AP3M2,COL11A1,ING1,CXCL2,FCGBP,KCND2,EIF3C,DDX11,BMP4,CTGF,TYRO3,GYG2,ACP5,NR4A3,PRG4,IRX3,RARA,LYVE1,MCL1,PIK3C2B,MT1X,PLEC,FAHD2A,HBEGF,JUNB,PARP3,RNASEH2A,NLRX1,FAHD2B,FARSA,MAP3K12,DPH2,EEF2KMT,C19orf53,PDE1B,RTN4,CCT3,NOTCH1,ANG,SORL1,AKAP12,SQLE,FYN,ZFP36,GSTM5,CRTAP,HEATR1,NQO2,ATAT1,FAM174B,FKBP1A,H2AFZ,SF3B3,EIF4EBP1,C20orf96,ENAH,NDUFB9,CES1,JUN,ZNF334,CSF2RA,ZNF608,TUB,CD24,EGFL6,FUK,AHNAK2,LIMCH1,GJB2,RPS24,NAP1L4,CEP164,CD276,STAMBPL1,WDR55,COL12A1,EGR1,SLIT2,AXL,RELN,COPS3,PLA2G2A,ANXA3,PTGS2,FBXW9,MAMSTR,COBLL1,PFN1,FAT1,CD4,LHCGR,METAP2,WDR5,H2AFY2,GSPT1,CNDP2,ALDH1A1,SLC25A6,ETS2,COMT,BCL7C,AMPH,C1QBP,RET,MT1G,PTPRE,GSDMB,EGR3,LAGE3,PAWR,PCDHA1,ANKRD33,ZNHIT1,SORD,SCRIB,LMAN2L,CRABP2,SFRP2,HIGD1A,ATF5,PTPRF,ARHGAP17,THBS1,NCL,MAPKAPK2,CHEK2,ADRB2,BEX2,TPST2,ATP2C1,C9orf3,LRRK2,CCDC85A,DHX37,THRSP,COL1A1,PLEKHH1,CYC1,PLP2,MT1F,GPR160,C6,KDR,CLEC10A,HCAR3,SYTL2,CACNA1H,COL8A1,SPI1,MT1E,CLIP1,ODC1,ZNF263,IP6K3,NUP93,CYBA,IQCC,KEAP1,CAV1,ATF4,TSHZ2,MRPL24,ALDOC,PIGT,PDIA5,SELE,SOGA1,TIMM44,PPP1R1B,TNFRSF10B,SMG5,MASP1,LAMC3,BRF2,MAMDC2,GPX7,HAX1,SHROOM4,NRBP1,TNPO2,CTSA,FSCN1,BTG2,SAMD4A,APOE,NME1,FGF2,SCUBE2,CEBPD,CDK4,CTDSPL,MMP25,KLHDC9,COL16A1,PNPO,CCL2,PLIN2,NOL12,FAM96B,ADORA1,HCAR2,TBC1D10B,RAD21,MRPL12,NLGN4X,C1orf122,FAM178B,FOS,ARHGEF5,HP,NRXN2,NR4A2,NTRK3,TAGLN,TMEM106C,SLC22A18,ARHGDIA,C19orf12,MAP3K8,PIN1,CPXM1,HAGH,ISM1,MT2A,PTTG1,PARP2,KLF6,TYMP,STYXL1,MYC,TGFBR2,ADGRF5,GSTM2,RHOB,GPR4,MAP2K2,HDAC11,CXCL14,FAR2,PDCD6,PFKFB3,ATF3,IER2,MAST4,VEGFC,PGAP3,DCHS1,KLF4,ELOVL6,FOSB,ABCA8,ORM1,DUSP1,GIPC1,LIMA1,IGFBP3,DNAJB6,MEGF8,ESR1,DPH5,PMEPA1,RUNX1,CDC20,FRZB,MECR,ABCF1,CCL3,REXO2,SHC1,TIMP1,MCAM,MKL2,LOC102724428/SIK1,LONP1,AGT,PARVA,C4BPB,TUBG1,UPP1,NQO1,BSCL2,PNCK,NFE2L1,SH3PXD2A,XYLT2,CLGN,TACC2,CAT,NOP16,ALKBH3,DPYD,APOB,ITSN1,TGFBR3,HRAS,CDKN2C,VWA5A,PCOLCE,NEU1,SLC4A3,PEX16,CLCNKA,ABR,ABCC1,ZHX2,ANK2,VEGFD,IRS2,HEY2,WNT5B,FANCG,GSTM3,TUBB2A,MMP2,IER3,TNK2,UBQLN4,COLEC12,CDH2,SRGAP3,TIMP4,ASGR1,CCND2,CD68,BSG,MS4A4A,MAP3K20,ADAMTS18,ALDOA,TRO,GLUL,RPL6,MAP2K3,HSPB7,MAPK7,SFRP1,AIDA,CYR61,MYEOV,HIST1H1C,ADAM17,PIGO,GRB14,NID2,UHRF1BP1,TNFSF10,XPOT,PFKL,MYH11,DCLK1,TAX1BP3,VCAN,TMEM94,IDH1,FANCE,COL5A1,TRIB1,MTOR,GBA,ALDH1A3,CLMN,SH3GLB2,TPO,PCBP2,PLOD3,PLAT,MYCN,SOX7,GSTM1,ADRM1,DPAGT1,RRP12,POLD1,YBX2,F11R,COL5A3,KRT8,S100A9,CDK20,IPO13,CNN1,PELI1,LSP1,DVL3,CBX4,ZFP36L2,MAPRE3,CYP2C8,FBN2,RGS1,PLA2G15,CXCL12,UTP4,TPM1,TUBB,COBL,CCNL1,MTCH2,ASXL2,BRSK1,EIF5,KPNA2,SIAH2,MYO10,AGBL5,ACTA1,PDK4,EIF2AK1,CSF3R,IGFBP6,MIF,AXIN2,SPP1,LMNA,MARS,PKN1,PPP2R1A,SMOX,AKR1B1,AOC3,ADAMTS7,PRDX5,FLRT2,BCL2L12,PKM,ABL1,RBBP8,SLC7A1,TNFAIP3,TET1,MYLK,ITGA10,SIL1,HIF1A,COL1A2,EPHB6,HMOX1,AEBP1,CSPG4,FLNA,CLOCK,KIT,ARHGEF2,NEK7,S100A8,CUL9,ALPL,HMGCS1,PI4KB,NDUFAF3,TAF6,CXCR4,VWCE,SMAD7,QSOX1,ZBTB7C,CSF1R,ENO1,DIP2C,LPAR1,EXOC4,RDH5,UBA1,MMP9,SHMT2	540	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	large intestine neoplasm	large intestine neoplasm	1.89E-15	 	1.427	 	1.867	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,ACADVL,AP3M2,ING1,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,PRPH,CD209,STAMBPL1,BLMH,COL12A1,EGR1,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,DHTKD1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ZNF174,PTPRF,MAN2C1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,ANKRD20A4 (includes others),CCDC88C,SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,HELZ,SPRY1,MLF2,NLGN4X,OLFML3,DGAT2,FAM53B,MRPS25,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,ISM1,BZW2,TMEM8A,NTMT1,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,ESR1,LRRC47,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,PRKCE,NAA60,NAALAD2,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,EIF3K,EPHX1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,SPON1,DTNA,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,SYN1,GSDMC,VHL,SLC11A1,SULF1,PC,BMP2,ALDH2,ZFAND2A,EDN1,ERBB2,THBS4,NDUFV1,PATL1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,KCND2,DDX11,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,RAD23A,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,SLC48A1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,MAP1B,UNC5B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,GSK3B,GPC1,RET,HLA-F,STX11,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,APBA3,KIAA0922,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,EMILIN1,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,KLHDC8B,PAPLN,HLA-DOA,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,MAMDC2,TFPI2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,FOS,NLE1,ABCC3,ABCB6,MT2A,CH25H,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,SLF2,PTTG1,DPP7,POLR3E,PARP2,OGFOD1,STYXL1,CLPP,AP2A2,GPR4,KCNAB1,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,UNC13B,LAMA2,CLIP2,PGAP3,CAPG,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,ABCF1,STX6,CRYL1,KIFC2,GLRX,GCDH,HNRNPK,SHC1,POLR1C,DECR2,MKL2,LRPPRC,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,LARP6,NUP210L,TUBGCP2,ANGPTL5,PMP22,CIDEA,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,DPYD,C1orf115,APOB,CAMK1,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,MATK,CACHD1,CALCRL,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,RAMP3,MAP2K3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,IDH1,UCHL1,FANCE,EFNB2,SLC2A6,STARD13,SNX10,KIAA0391,LDLRAP1,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,MGMT,CYP1B1,KRT8,PLEKHG6,TF,CDK20,PPP1R16B,WAS,ZSCAN18,ADCY1,MS4A2,S1PR1,NR5A2,CBX4,DVL3,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,CDH23,RBBP8,ABL1,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,SOX17,COL1A2,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,ZBTB7C,TRIP6,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,PLAUR,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,MTSS1,LHPP,SOGA1,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,CTHRC1,CRAT,DUSP22,TECR,COPS8,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,CPXM1,ST3GAL4,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,CES2,IMP4,TPRN,ZNF598,GYPE,STAB1,NBAS,ATF3,RILPL1,TRIM35,CDC42BPB,TLN2,PLEKHF1,MATN2,VPS37A,CCPG1,C2,MAST2,ERAP2,PTGFR,FAM107A,FAM20B,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,VPS4A,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,OLFML2A,TIMP1,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,NUSAP1,PARVA,VCAM1,APBB1IP,SLC12A2,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,GTF2IRD1,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,TCTN1,RERGL,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PTK7,PLAT,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,AKR1B1,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,C1QTNF1,PNMAL1,FUBP3,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,PTGIS,HEYL,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,CCT5,ACTG2,WDR4,MARCO,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,RARRES3,IDO1,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,C2orf88,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,C1QC,SLC9A1,ADCK1,ZNF263,EGR2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,CAV1,ATF4,EBF2,STK32A,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,NRDE2,IFT122,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,ZMYND19,CHDH,IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,PLA2G4A,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,ARHGEF16,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,WARS2,HHATL,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,SLC22A5,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1729	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal tumor	intestinal tumor	2.98E-15	 	1.680	 	2.581	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,ACADVL,AP3M2,ING1,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,PRPH,CD209,STAMBPL1,BLMH,COL12A1,EGR1,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,DHTKD1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ZNF174,PTPRF,MAN2C1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,ANKRD20A4 (includes others),CCDC88C,SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,OLFML3,DGAT2,FAM53B,MRPS25,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,ISM1,BZW2,TMEM8A,NTMT1,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,ESR1,LRRC47,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,PRKCE,NAA60,NAALAD2,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,EIF3K,EPHX1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,SPON1,DTNA,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,SYN1,GSDMC,VHL,SLC11A1,SULF1,PC,BMP2,ALDH2,ZFAND2A,EDN1,ERBB2,THBS4,NDUFV1,PATL1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,KCND2,DDX11,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,RAD23A,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,SLC48A1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,UNC5B,MAP1B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,GSK3B,GPC1,RET,HLA-F,STX11,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,APBA3,KIAA0922,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,ZFP42,EMILIN1,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,KLHDC8B,PAPLN,HLA-DOA,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,MAMDC2,TFPI2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,FOS,NLE1,ABCC3,ABCB6,MT2A,CH25H,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,SLF2,PTTG1,DPP7,POLR3E,PARP2,OGFOD1,STYXL1,CLPP,AP2A2,GPR4,KCNAB1,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,UNC13B,LAMA2,CLIP2,PGAP3,CAPG,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,ABCF1,STX6,CRYL1,KIFC2,GLRX,GCDH,HNRNPK,SHC1,POLR1C,DECR2,MKL2,LRPPRC,TOX2,MCRS1,AGT,SUGP2,PWWP2B,NQO1,LARP6,NUP210L,TUBGCP2,ANGPTL5,PMP22,CIDEA,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,DPYD,CAMK1,C1orf115,APOB,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,MATK,CACHD1,CALCRL,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,RAMP3,MAP2K3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,IDH1,UCHL1,FANCE,EFNB2,SLC2A6,STARD13,SNX10,KIAA0391,LDLRAP1,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,MGMT,CYP1B1,KRT8,PLEKHG6,TF,CDK20,PPP1R16B,WAS,ZSCAN18,ADCY1,MS4A2,S1PR1,NR5A2,CBX4,DVL3,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,ABL1,CDH23,RBBP8,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,SOX17,COL1A2,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,ZBTB7C,TRIP6,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,PLAUR,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,CCDC68,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,SORD,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,MTSS1,LHPP,SOGA1,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,MRPL17,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,CTHRC1,CRAT,DUSP22,TECR,COPS8,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,CPXM1,ST3GAL4,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,CES2,IMP4,TPRN,ZNF598,GYPE,STAB1,NBAS,ATF3,RILPL1,TRIM35,CDC42BPB,TLN2,PLEKHF1,MATN2,VPS37A,CCPG1,C2,MAST2,ERAP2,PTGFR,FAM107A,FAM20B,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,VPS4A,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,OLFML2A,TIMP1,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,NUSAP1,PARVA,VCAM1,APBB1IP,SLC12A2,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,GTF2IRD1,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,TCTN1,RERGL,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PTK7,PLAT,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,AKR1B1,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,C1QTNF1,PNMAL1,FUBP3,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,PTGIS,HEYL,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C9orf16,C1QTNF6,PRKCD,RARRES3,IDO1,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,C2orf88,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,C1QC,SLC9A1,ADCK1,ZNF263,EGR2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,CAV1,ATF4,EBF2,STK32A,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,NRDE2,IFT122,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,ZMYND19,CHDH,IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,PLA2G4A,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,ARHGEF16,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,WARS2,HHATL,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,SLC22A5,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,CDKN2B,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1732	
Cardiovascular System Development and Function, Cellular Movement	migration	migration of endothelial cells	3.05E-15	 	-1.146	 	-3.540	SLIT3,BMP4,CTGF,HRAS,HOXA9,NEU1,ITGA3,CAV1,MGP,VEGFD,ETS1,SFRP4,PIK3C2B,ARHGEF4,SELE,THY1,MMP2,THBD,S1PR3,CDH5,ARHGEF6,RTN4,ALCAM,MAP2K3,CYR61,mir-21,NRP1,ADM,CNN2,APOE,FGF2,GNA11,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,CCL2,GADD45A,STARD13,PRKCE,CSNK2B,COL18A1,HEY1,PLXNA1,ANGPT1,TJP1,ZNF580,SLIT2,AXL,ID3,IGF2R,CYP1B1,GRN,F11R,PLA2G4A,CBS/CBSL,ANXA3,S1PR1,PTGS2,BMP6,ADGRA2,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,HSPA5,MYC,TGFBR2,ESAM,RHOB,STAB1,PDCD6,GSK3B,GPC1,KLF2,TEK,ELN,CXCL8,NOX4,SPP1,ADAMTS1,VEGFC,THRA,TARS,FOXC1,STC1,ORM1,GIPC1,IGFBP3,MDK,S100P,LOX,LEP,BMP2,PKM,HIF1A,TNFRSF12A,ANGPTL4,EDN1,FLNA,THBS1,TIMP1,SAA1,MCAM,ERBB2,NCL,MAPKAPK2,AGT,SRC,VCAM1,G6PD,PLAUR,WARS,VAV3,SPARC,KDR,MMP9	120	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoplasm	3.06E-15	 	1.873	 	-1.912	KCNJ2,PCLO,AXIN1,C1QA,IL6,IDUA,AJUBA,GLB1,TSC2,MAP1A,PLXNB2,AMHR2,WASH3P,TNFRSF21,ETS1,LARP4,DVL2,PDLIM7,ACACA,mir-21,EIF4EBP2,ADIPOQ,HEXA,SYNM,LLGL1,PVR,MYO5A,SWAP70,LYN,SOX9,LIG1,MICALL2,DPYSL4,FCER1A,CEP104,ARHGAP20,MARCO,CXCL8,MAPK8IP2,RIMS4,TXNRD1,ADRA2A,NAGLU,SYN1,VHL,UBE2I,LOX,SULF1,KIZ,BMP2,FLRT1,CLUAP1,INPPL1,PHLDB2,HDGF,EDN1,ERBB2,THBS4,SRC,PKP1,NLRP3,NSFL1C,PLAUR,KIF3B,BTK,SPARC,BMP4,CTGF,RAN,POMC,MIA,EVI5L,ITGA3,PLS3,MTUS1,KIF21A,AFAP1,TESK1,RND2,CAPN6,ATG7,PLEC,GRK5,CEP89,PARP3,THBD,ROR1,NINJ1,MAP3K12,RTN4,GDPD5,CAPRIN1,NOTCH1,B9D1,NRP1,AKAP12,CNN2,FYN,ATP6V1D,BTG3,EFHD1,CASP4,ENAH,EIF4EBP1,KLF9,JUN,RHOD,TUB,NPTXR,PRPH,CEP164,PTPRK,CSK,EGR1,DAAM1,ARHGAP4,TMED2,CCDC8,SLIT2,AXL,RELN,TENM4,PTGS2,TM4SF1,PFN1,FARP1,FAT1,MAP1B,UNC5B,MNS1,CLIP3,WDR5,COMT,MID1IP1,GSK3B,C1QBP,RET,FERMT3,TTYH1,PTPRE,ACP2,SHARPIN,EGR3,ACAP1,MAPK8IP3,RAP1GAP,PRKCD,RARRES3,UVRAG,CDK5RAP2,ARL2,SPIRE1,--,ICK,NGF,PTPRF,RAB5A,NFKBIA,ANGPTL4,ARHGAP17,DKK3,THBS1,STK24,SULF2,HMGCL,MAPKAPK2,IFRD1,PAK4,EPAS1,ATP2C1,LRRK2,PRMT1,KIF2A,EPHB3,GAP43,NCKAP1L,KDR,SLIT3,MAP6,CACNA1H,PLEKHM2,SPI1,SLC9A1,CLIP1,CAV1,DLG4,VPS4B,STK36,MTSS1,CARMIL1,MAD2L2,FLOT1,SHROOM4,TMEM127,IFT122,FSCN1,NCF2,ARHGEF6,BTG2,ATMIN,GAPDH,ITGA1,APOE,NME1,PLXNA3,TTLL3,CHCHD10,FGF2,GDF15,MTFP1,CKAP4,TGM2,CCL2,SORBS1,RAD21,LIG3,S100A1,CUL7,GFRA2,GPM6B,GRN,ARHGEF5,FOS,MYOC,LDLR,NTRK3,FLNC,TPP1,ARHGDIA,AFG3L2,PIN1,BMP6,KTN1,MAOA,MT2A,NCDN,SESN2,ATP2B1,MBP,NTMT1,MYC,NNMT,ADGRF5,RHOB,MAP2K2,CAST,ATF3,PEX7,LAMA2,VEGFC,CAPG,ARSA,MLST8,SLC3A2,CDC42BPB,PLEKHF1,MATN2,CAPN2,DNAJB6,ESR1,TMEM138,FAM107A,SPIRE2,CDC20,STX6,ATF6,CCL3,HNRNPK,SH3D19,SHC1,NET1,MKL2,LOC102724428/SIK1,LONP1,AGT,ZNF135,NUSAP1,PARVA,APBB1IP,TUBG1,NQO1,EMD,CANX,TUBGCP2,TMED9,ZPR1,SLK,KCTD13,PMP22,CAPNS1,TACC2,KIF5B,VAV3,TBC1D7,DNM1L,ITSN1,SGK1,SH3GLB1,HRAS,RAPH1,LPIN1,PEX16,ABR,GAA,ABCC1,DNAJA3,VEGFD,MATK,ARHGEF4,RIMS3,PEX6,NDRG1,RRBP1,CHN1,FANCG,STOML2,THY1,TNK2,S1PR3,DOCK1,SRGAP3,CDH2,BSG,PIP5K1C,STIP1,MAP3K20,ALDOA,RSU1,LRP8,SFRP1,CYR61,PDGFD,ADM,SPTBN1,TCTN1,RALA,WASF3,TNFSF10,DCLK1,UCHL1,ID1,DCLK2,EFNB2,MTOR,SEC61A1,SRGAP1,CLMN,SNX10,RHOU,PRKCE,RASSF5,TBCD,NCKIPSD,PTK7,IL11RA,PLAT,GSTM1,VPS18,S100A9,TF,PLEKHG6,WAS,LSP1,ADCY1,FKBP4,S1PR1,DBNL,ALS2CL,GABARAP,RUFY3,MAPRE3,RAB43,RAB3IP,PTPN23,ADRBK1,CXCL12,TPM1,SDC4,CDC42EP2,DYNLT1,TUBB,PLEKHG4,PARVB,CRIP1,BRSK1,NEO1,KLF2,MYO10,RTN4R,ADRA1B,PTX3,SPP1,LMCD1,ITGAM,CORO1B,PKD1,SLC22A5,SNX1,KATNB1,MAP2K5,GDI1,LEP,RNF165,NFIX,EPB41L3,NLGN1,ERN1,VAPA,ANTXR1,PKM,ABL1,SMPD1,PRKCSH,TNFRSF12A,EPHB6,CCL13,FLNA,KIT,MICALL1,NSMF,NEK7,S100A8,ARHGEF2,CUL9,MYO16,ACTN1,PI4KB,PRNP,CXCR4,F13A1,SCIN,TRIP6,CSF1R,LPAR1,DYM,EDNRA,ELK1,YME1L1,EPB41L2,RTN3,P2RX7	441	
Cardiovascular System Development and Function	morphology	morphology of cardiovascular system	3.44E-15	 	 	 	 	RRM2B,CACNA1H,COL8A1,IL6,SPI1,ATP2A2,POR,IDUA,CCND3,LUM,MGP,CAV1,CASQ2,PTGIS,ETS1,HEYL,RBM38,MFAP5,C1GALT1C1,GPX7,IFT122,DVL2,CDH5,PPP1R15A,TFRC,APOE,FGF2,CFC1/CFC1B,ADIPOQ,CDK4,COL15A1,TGM2,GADD45A,LY6E,GNG5,CYP51A1,HEY1,MECOM,MESP1,SLCO2A1,CDO1,TK2,IGF2R,PLA2G4A,ZFPM2,LDLR,CBS/CBSL,NTRK3,SERPINH1,LYN,ARHGDIA,MAN2B1,SGCD,LIG1,ADGRA2,GPC3,BIN1,MYC,TGFBR2,GPR4,BIRC3,TEK,ELN,NOX4,PKP2,SGCB,DCHS1,BCL2L1,NOL3,ALDH1A2,FZD5,CAPN2,MDK,MEGF8,TXNRD2,VHL,RBP4,LOX,BMP2,ETV6,CIAPIN1,SHC1,EDN1,MKL2,ENPP2,ERBB2,AGT,SRC,EPN1,DHRS3,VCAM1,G6PD,EMD,SNX27,BSCL2,KIF3B,RCAN1,CAPNS1,ACADVL,VAV3,EFEMP2,BMP4,APOB,TGFBR3,TYRO3,NCSTN,CDKN2C,ITGA3,MFAP2,LGMN,RARA,GAA,HEY2,HADHA,CALCRL,ATG7,PLEC,HBEGF,MMP2,HMGA1,IER3,THBD,PLOD1,S1PR3,DOCK1,TIMP4,CDH2,CCND2,EPB42,MAP2K3,MAPK7,NOTCH1,COL3A1,B9D1,NRP1,SPTBN1,AKAP12,ADM,HIST1H1C,ADAM17,SIN3B,FKBP1A,MYH11,COL5A1,EFNB2,JUN,CST3,COL18A1,PLOD3,MYCN,ANGPT1,AXL,F11R,CNN1,BNIP3L,GPR180,DVL3,ARID4A,ADRBK1,CD36,PLA2G15,CXCL12,RSPO3,PLCE1,OSR1,SIAH2,RET,KLF2,ADRA1B,EIF2AK1,SPP1,SGCG,LMNA,PKD1,TMOD1,MAP2K5,FLRT2,SLC4A11,ABL1,SLC7A1,HIF1A,RAMP2,HMOX1,FLNA,THBS1,RPS6KB2,SMO,HMGCL,ACADM,PTGER4,PAK4,CXCR4,MTMR14,SMAD7,COL1A1,ITPA,GBE1,EDNRA,NCKAP1L,RCAN2,MMP9	201	
Cell Death and Survival	necrosis	necrosis of epithelial tissue	4.72E-15	 	-1.231	 	-1.579	BMP4,ITSN1,SGK1,ASS1,HRAS,MST1,SERPINA3,POMC,IL6,MIA,NR4A3,SGPL1,ITGA3,MCOLN3,ABCC1,LUM,CAV1,TXN,HIPK2,ALDH3A1,MCL1,PTGIS,HEYL,COMP,ATG7,NDRG1,TNFRSF10B,MMP2,IER3,THBD,HAX1,CDH2,CDH5,PPP1R15A,CTSB,GAPDH,TFRC,MAP2K3,MAPK7,SFRP1,mir-21,ADM,SPTBN1,FYN,ADAM17,GADD45B,DDIT3,FGF2,PSMB10,NQO2,SEMA6A,GDF15,CEBPD,ADIPOQ,TNFSF10,CASP4,MEOX2,TGM2,EFNB2,CA3,ID1,MTOR,JUN,GADD45A,DAP3,PRKCE,DAB2,RASSF5,COL18A1,NDUFAB1,RAD21,PLAT,MYCN,UCP2,MECOM,ANGPT1,EMP3,EGR1,CUL7,TRIB3,AXL,SRXN1,FOS,PLA2G4A,KRT8,MYOC,LDLR,CBS/CBSL,NTRK3,BMF,LYN,PEA15,S1PR1,FKBP4,PROCR,BNIP3L,MAP3K8,PTGS2,BMP6,MAOA,RFXANK,ISM1,SOCS3,TFF3,ADRBK1,CD36,CD4,UNC5B,SPHK2,CXCL12,TYMP,ARG2,HSPA5,MYC,TGFBR2,TNIP1,IKBKG,ALDH1A1,RHOB,PLA2G5,GSK3B,BIRC3,KLF2,HK1,CXCL8,MIF,TJP2,ATF3,SPP1,ADAMTS1,PAWR,BCL2L1,NOL3,ERCC1,TRIM39,PKD1,PRKCD,HIF1AN,IGFBP3,RGN,ALDH3B1,ESR1,MLKL,RBP4,LEP,ERN1,ABL1,TNFAIP3,SMPD1,MYLK,IRF3,NGF,HMOX1,SHC1,ALDH2,NFKBIA,EDN1,RGS5,TIMP1,THBS1,MCAM,SAA1,S100A8,ERBB2,SEMA3B,MAPKAPK2,NCL,ATP13A2,PRNP,AGT,FAAH,SLC20A1,SRC,NLRP3,CXCR4,PLAUR,CSF1R,FAIM,PRMT1,RBCK1,EMP1,PMP22,RRAS2,CAT,SPARC,ELK1,KDR,DNM1L,TNFRSF19,P2RX7,SLC47A1,MMP9	192	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of leukocytes	9.69E-15	 	-0.077	 	-3.031	CTSG,SERPINA3,IL6,SPI1,EGR2,MYADM,LUM,CAV1,TNFRSF21,ETS1,SELE,ANO6,FLOT1,PPP1R15A,CTSB,CD86,ALCAM,ITGA1,PLTP,PTPRA,APOE,DAPK2,GNA11,GDF15,ACKR2,ADIPOQ,G6PC3,TGM2,CCL2,SOS1,PIK3R2,ADORA1,HCAR2,FCGR3A/FCGR3B,CCR1,UCP2,ZNF580,CD69,RGS16,PVR,GRN,GPR183,FOS,PLA2G4A,HP,SWAP70,LDLR,LYN,PROCR,MAP3K8,QPCT,SOCS3,RARRES2,FCER1A,MYC,TGFBR2,RHOB,CXCL14,STAB1,CAST,MARCO,ELN,CXCL8,VEGFC,CAPG,GNAZ,PTGDS,DUSP1,IGFBP3,MDK,ESR1,C2,RUNX1,TNFAIP8,LITAF,SFTPD,CCL3,ETV6,HLA-G,SHC1,EDN1,TIMP1,MCAM,SAA1,ENPP2,ERBB2,AGT,THBS4,SRC,VCAM1,NLRP3,MMP28,NQO1,PLAUR,TNFRSF14,BTK,CXCL16,VAV3,SPARC,CXCL2,CTGF,ELANE,HRAS,MST1,POMC,HOXA9,SGPL1,ITGA3,RARA,ABCC1,VEGFD,TXN,CMKLR1,NDRG1,PLEC,THY1,MMP2,THBD,NINJ1,S1PR3,AQP9,YARS,PIP5K1C,MS4A4A,RTN4,IL10RA,SFRP1,MAPK7,CYR61,NOTCH1,ADM,CNN2,FYN,ADAM17,NQO2,HYOU1,TNFSF10,VCAN,EFNB2,MTOR,CES1,JUN,GBA,CCL3L1,CCL8,CCL3L3,CSF2RA,CST3,STIM1,LBP,RASSF5,GJB2,IL11RA,PLAT,CD209,CD276,C5AR1,ANGPT1,TYROBP,CSK,HDC,DEFB1,SLIT2,F11R,S100A9,WAS,LSP1,PELI1,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,TNFRSF4,PFN1,ADRBK1,CD36,CD4,UNC5B,SPHK2,CXCL12,HARS,CYP26B1,RSPO3,NARS,IKBKG,PLA2G5,NEO1,LTBR,C1QBP,FAM65B,KLF2,FERMT3,PTX3,CSF3R,MIF,SPP1,TPSAB1/TPSB2,APBA3,STC1,EFS,ITGAM,RAP1GAP,PRKCD,CD14,IDO1,CCL18,AOC3,LEP,ABL1,TNFAIP3,MYLK,SMPD1,HIF1A,NGF,HMOX1,CD55,NFKBIA,CCL13,FLNA,THBS1,DUSP10,CFB,KIT,S100A8,MAPKAPK2,ADRB2,PRNP,EPAS1,CXCR4,PCOLCE2,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,COL1A1,CYTIP,EDNRA,C6,NCKAP1L,KDR,P2RX7,MMP9	244	
Cardiovascular System Development and Function	abnormal morphology	abnormal morphology of cardiovascular system	2.09E-14	 	 	 	 	TGFBR3,RRM2B,TYRO3,CACNA1H,CDKN2C,COL8A1,NCSTN,IL6,ATP2A2,SPI1,POR,IDUA,MFAP2,ITGA3,LGMN,CCND3,GAA,RARA,LUM,MGP,CAV1,HEY2,HADHA,CASQ2,PTGIS,RBM38,CALCRL,MFAP5,PLEC,C1GALT1C1,HBEGF,MMP2,IER3,HMGA1,THBD,GPX7,PLOD1,S1PR3,DOCK1,DVL2,IFT122,CDH2,TIMP4,CCND2,CDH5,EPB42,PPP1R15A,TFRC,MAPK7,NOTCH1,NRP1,B9D1,COL3A1,ADM,AKAP12,SPTBN1,APOE,HIST1H1C,ADAM17,FGF2,CFC1/CFC1B,SIN3B,CDK4,ADIPOQ,FKBP1A,MYH11,COL15A1,TGM2,COL5A1,EFNB2,JUN,GADD45A,CST3,LY6E,COL18A1,CYP51A1,PLOD3,HEY1,MYCN,MECOM,MESP1,SLCO2A1,CDO1,TK2,AXL,IGF2R,PLA2G4A,LDLR,ZFPM2,CBS/CBSL,NTRK3,LYN,BNIP3L,MAN2B1,GPR180,ARHGDIA,DVL3,SGCD,ARID4A,ADGRA2,ADRBK1,CD36,PLA2G15,CXCL12,GPC3,BIN1,MYC,TGFBR2,RSPO3,PLCE1,GPR4,OSR1,RET,BIRC3,KLF2,TEK,ADRA1B,EIF2AK1,ELN,NOX4,SPP1,SGCG,PKP2,LMNA,SGCB,DCHS1,BCL2L1,NOL3,PKD1,ALDH1A2,CAPN2,FZD5,MDK,MEGF8,TXNRD2,VHL,RBP4,LOX,BMP2,SLC4A11,FLRT2,ABL1,SLC7A1,HIF1A,RAMP2,ETV6,CIAPIN1,SHC1,HMOX1,EDN1,THBS1,FLNA,SMO,RPS6KB2,MKL2,ENPP2,ERBB2,HMGCL,ACADM,PTGER4,AGT,VCAM1,PAK4,DHRS3,EPN1,CXCR4,MTMR14,G6PD,SMAD7,EMD,SNX27,BSCL2,KIF3B,COL1A1,RCAN1,CAPNS1,ITPA,ACADVL,VAV3,EDNRA,GBE1,EFEMP2,RCAN2,MMP9	184	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoskeleton	2.39E-14	 	1.819	 	-1.948	KCNJ2,PCLO,AXIN1,C1QA,IL6,AJUBA,GLB1,TSC2,MAP1A,PLXNB2,AMHR2,TNFRSF21,ETS1,LARP4,DVL2,PDLIM7,ACACA,mir-21,EIF4EBP2,ADIPOQ,SYNM,LLGL1,PVR,MYO5A,SWAP70,LYN,SOX9,LIG1,DPYSL4,MICALL2,FCER1A,CEP104,ARHGAP20,MARCO,CXCL8,MAPK8IP2,RIMS4,TXNRD1,ADRA2A,SYN1,VHL,UBE2I,LOX,SULF1,KIZ,BMP2,FLRT1,CLUAP1,INPPL1,PHLDB2,HDGF,EDN1,ERBB2,SRC,THBS4,PKP1,NLRP3,PLAUR,KIF3B,BTK,SPARC,BMP4,CTGF,RAN,POMC,MIA,EVI5L,ITGA3,PLS3,MTUS1,KIF21A,AFAP1,TESK1,RND2,CAPN6,ATG7,PLEC,GRK5,CEP89,PARP3,THBD,ROR1,NINJ1,MAP3K12,RTN4,GDPD5,CAPRIN1,NOTCH1,B9D1,NRP1,AKAP12,CNN2,FYN,ATP6V1D,BTG3,EFHD1,CASP4,ENAH,EIF4EBP1,KLF9,JUN,RHOD,TUB,NPTXR,PRPH,CEP164,PTPRK,CSK,EGR1,DAAM1,ARHGAP4,CCDC8,SLIT2,AXL,RELN,TENM4,PTGS2,TM4SF1,PFN1,FARP1,FAT1,MAP1B,UNC5B,MNS1,CLIP3,WDR5,COMT,MID1IP1,C1QBP,GSK3B,RET,FERMT3,TTYH1,PTPRE,EGR3,ACAP1,MAPK8IP3,RAP1GAP,PRKCD,RARRES3,UVRAG,CDK5RAP2,SPIRE1,ARL2,--,ICK,NGF,PTPRF,RAB5A,ANGPTL4,NFKBIA,ARHGAP17,DKK3,THBS1,STK24,SULF2,MAPKAPK2,IFRD1,PAK4,ATP2C1,LRRK2,PRMT1,KIF2A,EPHB3,GAP43,NCKAP1L,KDR,SLIT3,MAP6,CACNA1H,SPI1,SLC9A1,CLIP1,CAV1,DLG4,STK36,MTSS1,CARMIL1,MAD2L2,FLOT1,SHROOM4,IFT122,FSCN1,NCF2,ARHGEF6,BTG2,ATMIN,GAPDH,ITGA1,APOE,NME1,PLXNA3,TTLL3,FGF2,GDF15,CKAP4,TGM2,CCL2,SORBS1,RAD21,S100A1,CUL7,GFRA2,GPM6B,GRN,ARHGEF5,FOS,MYOC,LDLR,NTRK3,FLNC,ARHGDIA,AFG3L2,PIN1,BMP6,KTN1,MAOA,MT2A,NCDN,ATP2B1,MBP,NTMT1,MYC,NNMT,ADGRF5,RHOB,MAP2K2,CAST,ATF3,LAMA2,VEGFC,CAPG,ARSA,MLST8,SLC3A2,CDC42BPB,MATN2,CAPN2,DNAJB6,ESR1,TMEM138,FAM107A,SPIRE2,CDC20,ATF6,CCL3,HNRNPK,SH3D19,SHC1,NET1,MKL2,LOC102724428/SIK1,AGT,ZNF135,NUSAP1,PARVA,APBB1IP,TUBG1,NQO1,CANX,TUBGCP2,ZPR1,SLK,KCTD13,PMP22,CAPNS1,TACC2,KIF5B,VAV3,TBC1D7,DNM1L,ITSN1,SGK1,HRAS,RAPH1,LPIN1,ABR,ABCC1,DNAJA3,VEGFD,MATK,RIMS3,ARHGEF4,NDRG1,RRBP1,CHN1,THY1,TNK2,S1PR3,DOCK1,SRGAP3,CDH2,BSG,PIP5K1C,STIP1,MAP3K20,ALDOA,LRP8,RSU1,SFRP1,PDGFD,CYR61,ADM,SPTBN1,TCTN1,RALA,WASF3,TNFSF10,DCLK1,UCHL1,ID1,DCLK2,EFNB2,MTOR,SRGAP1,CLMN,SNX10,RHOU,PRKCE,RASSF5,TBCD,NCKIPSD,PTK7,IL11RA,PLAT,GSTM1,S100A9,TF,PLEKHG6,WAS,LSP1,ADCY1,FKBP4,S1PR1,DBNL,GABARAP,RUFY3,MAPRE3,RAB3IP,PTPN23,ADRBK1,CXCL12,TPM1,SDC4,CDC42EP2,DYNLT1,TUBB,PLEKHG4,PARVB,CRIP1,BRSK1,NEO1,KLF2,MYO10,RTN4R,ADRA1B,SPP1,LMCD1,ITGAM,CORO1B,PKD1,SNX1,KATNB1,MAP2K5,GDI1,LEP,RNF165,NFIX,EPB41L3,NLGN1,ERN1,VAPA,ANTXR1,PKM,ABL1,SMPD1,PRKCSH,TNFRSF12A,EPHB6,CCL13,FLNA,MICALL1,KIT,NSMF,NEK7,S100A8,ARHGEF2,CUL9,MYO16,ACTN1,PI4KB,PRNP,CXCR4,F13A1,TRIP6,SCIN,CSF1R,LPAR1,EDNRA,EPB41L2,ELK1,RTN3,P2RX7	403	
Cancer, Organismal Injury and Abnormalities	head and neck neoplasia	head and neck neoplasia	2.44E-14	 	-1.301	 	-0.305	PCLO,ASS1,POR,IDUA,AJUBA,GLB1,POMZP3,TSC2,SMARCB1,DEFB132,WASH3P,ETS1,RBM38,PLAG1,DVL2,mir-21,SYNM,RABL6,NAXE,GPC6,ATN1,MTSS1L,EMP3,POLR1E,GPAM,PDZD2,AFF3,KIF7,FAM136A,AKR1C3,C2CD4B,DPYSL4,INTS1,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,TEK,CPNE1,ADAMTS1,STX1A,UBL4A,FAAP20,KANK1,BCL2L1,H3F3A/H3F3B,DBNDD1,C19orf54,NAGLU,C17orf97,BAIAP2L2,SUN1,RAB11FIP5,FEM1A,ZP3,FLRT1,ZNF252P,GIMAP6,SH3PXD2B,COL6A1,ISCU,FAAP100,NLRP3,PLAUR,PYGB,FRMD4A,SAA2,ORAOV1,ING1,CXCL2,CTGF,HOMER3,RNF38,SGPL1,PRG4,MTUS1,PNKD,MCL1,POLR2I,CTNS,PPIL6,PIK3C2B,NAB1,SV2B,PLEC,GRK5,HMGA1,CHI3L2,THBD,MAP3K12,ACAD11,CORO7/CORO7-PAM16,FAM86B1,ISLR,AKR1C4,NOTCH1,TMEM158,NRP1,SUSD2,CNN2,SORL1,FCGRT,LEPR,SIN3B,FKBP1A,MEOX2,H2AFZ,ATP6AP1,CCL8,CST3,COL22A1,EGFL6,RNF135,AHNAK2,CD209,SLC25A13,ANKRD9,TRIM28,EGR1,DAAM1,RELN,SBF1,AOX1,PTGS2,CHD7,ZFYVE19,SPNS1,CLEC3B,ZNF91,FAM173A,COMT,DHTKD1,CYP4X1,NMNAT2,USP36,MTURN,SLC4A7,ALAD,TPSAB1/TPSB2,SORD,LRRC41,FRYL,SCRIB,MAN1B1,PTPRF,DKK3,THBS1,ARHGEF35,ASAP3,TPST2,PARP10,LRRK2,RPS21,CCDC85A,ANO2,SYBU,COL1A1,EBF1,PLEKHH1,FAM46A,MYPOP,XK,SLIT3,CSTA,HCAR3,SVEP1,MAP6,CACNA1H,ANKRD20A4 (includes others),ASCC2,MTX1,SPI1,ATP2A2,TYSND1,GATAD2A,GNA15,NUP93,RAB38,SLCO2B1,TSHZ2,ALDOC,RRP1,DPT,MTSS1,MFAP5,TNFRSF10B,RAB3IL1,LAMC3,GPX7,HAX1,AEN,WDR81,MN1,CHD1L,PTPRA,TRAPPC5,ZDHHC4,NME1,SLC4A2,ZNF205,C9orf24,GDF15,CDK4,CEBPD,CTHRC1,TECR,SDHAF1,ARFGAP1,IRF2BPL,SOS1,HCAR2,RAD21,CYP51A1,SPRY1,MLF2,GLRX2,RCCD1,MRPS25,FAM178B,ARHGEF5,LDLR,NTRK3,SERPINH1,BMPER,TP53BP1,BMP6,ID4,KTN1,TPPP3,KIAA1551,RTN1,HSPA1A/HSPA1B,ACO2,RNASE1,BIN1,MYC,TGFBR2,ZNF598,CXCL14,GYPE,KIF25,RPAP1,TEX264,FMO2,RILPL1,VEGFC,THRA,KCNK12,DCHS1,GZMH,ABCA8,GIPC1,MATN2,BUD31,APCDD1,ALDH1A2,SORCS2,THAP7,ESR1,S100P,PMEPA1,RBP4,POLR3F,SPIRE2,FRZB,SRPX,SCARA5,DENND4B,MECR,DCAF4,TPGS2,NEURL4,GSTT1,SLC2A3,IRAK1,CCDC107,HLA-DRB1,AHNAK,TIMP1,MEX3B,LOC102724428/SIK1,HES4,VARS,CIZ1,GJA4,NUSAP1,VCAM1,CTAGE9 (includes others),APBB1IP,SLC12A2,PGAP2,GNAI1,ATIC,SH3PXD2A,CLGN,LOC102724788/PRODH,PHF19,GAPVD1,TRAP1,PCDH7,CDKN2C,HOXA9,NCOA7,CLCNKA,SLC16A2,VEGFD,ALPK1,ARRDC4,MMP2,SERINC2,SRGAP3,MS4A7,LRP8,AIDA,PDGFD,ITGA7,ALDH4A1,SCAP,EMILIN2,PSMB10,PAM16,FOLR2,KAZN,PFKL,MTOR,TARS2,SRGAP1,ANXA5,DAP3,PRKCE,COL18A1,DNAH6,PTK7,GSTM1,F11R,COL5A3,FAM86C1,CLDN5,RBM6,SLC25A19,SYN2,C16orf89,CYP2C8,C10orf54,SERPINI1,PTPN23,CLTB,COBL,TMEM156,KPNA2,LTBR,CSF3R,CRISPLD2,SPP1,MACROD1,PCSK7,LMNA,DPP9,PANK1,GSR,CORO1B,CUEDC1,ADAMTSL2,ACOT4,LSM7,THSD7B,AKR1B1,RNPEP,AOC3,ADAMTS7,LEP,PRDX5,ERN1,CHPF,PCMT1,ADSL,FLNA,SRGN,HSD11B2,S100A8,MYO16,RAB11FIP3,TMEM132B,SNAPC4,FRMD1,CPED1,SMAD7,CSF1R,TRMT61A,URM1,LRP1B,ZNF585A,EPB41L2,ATP6V1B2,MMP9,CBX7,AXIN1,NOMO1 (includes others),IL6,POLRMT,UPK3BL,ATG9A,EIF3B,CCND3,PLXNB2,COMP,COCH,KIAA0513,CTSB,C15orf39,CD163L1,GNA11,COL15A1,DDX3X,SPON1,DTNA,MECOM,SPATS2L,THEM6,HNRNPH1,PROCR,LYN,SOX9,MXRA5,SOCS3,ARSD,ANKMY1,ZFPM1,AP1B1,GPC3,CEP104,KMT5A,CXCL8,MAN1C1,MAPK8IP2,RIMS4,H6PD,LZTR1,ERCC2,AKR1B10,ZNF296,FAM26F,SLC7A2,BAP1,VHL,UBE2I,SULF1,INPPL1,HLA-G,ALDH2,DHCR7,GTPBP2,EDN1,ERBB2,NDUFV1,SRC,THBS4,POLR3B,COL11A1,FCGBP,PRUNE2,KCND2,DDX11,BMP4,TYRO3,MST1,GYG2,BCAS4,POMC,EIF6,GSS,MIA,NR4A3,ITGA3,RARA,MGAT4B,MED16,TESK1,CAPN5,EFL1,SFRP4,TMEM37,DKC1,CEP89,CCZ1/CCZ1B,CCT3,AKAP12,MAP7,GSTM5,TTLL4,HYOU1,ATAT1,GPC4,RCOR2,TMEM259,TUSC5,THBS3,SF3B3,TIGD5,C20orf96,ENAH,RPUSD3,CES1,JUN,CD24,MYO1D,FUK,RBBP9,PLXNA1,CEP164,MYOM2,BHLHE22,ARHGAP4,WDR18,SLIT2,AXL,EMC1,YIF1B,GABRE,RBM42,BRINP2,BMF,UAP1L1,CILP,TM4SF1,TFF3,TNFRSF4,FARP1,MAP1B,UNC5B,TMEM147,GPC1,GSK3B,RET,PHACTR3,MFSD3,FUCA1,MT1G,TRIOBP,GSDMB,PCDHA1,UBXN11,KIAA0922,FLCN,CCDC184,RAP1GAP,N6AMT1,C2orf40,CLCN7,AMY1C (includes others),SFRP2,ATF5,SLC4A11,TBCB,KIAA0040,CFB,SMO,EXOSC7,NCL,CHEK2,ZFP42,RHBDD3,EMILIN1,ADRB2,BHLHE41,PCOLCE2,DHX37,LOC401052,PLBD2,EPHB3,CPZ,C6,KDR,CLEC10A,ANKRD35,PAPLN,HLA-DOA,CLIP1,FADS3,NSF,CTSH,MCOLN3,KIF1A,KEAP1,LUM,MGP,CEP170B,KANK3,DLG4,KAT2A,TM6SF1,FAM189B,SELE,PODN,IFNAR2,TFPI2,SHROOM4,ZNF579,HSPA8,CTSA,EVPL,NCF2,BTG2,SAMD4A,CHCHD10,FGF2,SEMA6A,THOC3,ZBTB9,CKAP4,HS3ST3A1,TGM2,CHDH,GADD45A,PGA5 (includes others),FCGR3A/FCGR3B,G3BP2,FCER2,MAPKAP1,GALM,GRN,FOS,HP,NRXN2,FLNC,ATP1A2,TAF1C,LRRC75B,TAGLN,AARS2,MAP3K8,TTYH3,ABCC3,ABCB6,FOXRED1,AMDHD2,SLC38A10,PTTG1,DPP7,ABCG1,C16orf91,GPR4,TMEM8B,FAR2,CHTF18,PDZRN3,LRBA,MYDGF,CLIP2,ANO1,KLF4,CYB561,TRIM39,ORM1,DUSP1,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,RUNX1,FDX1L,SF3B5,ABCF1,NUDT2,HNRNPK,RPL14,SHC1,MSRB3,SAA1,TOX2,MCRS1,RBPMS,C4BPB,SLC22A12,ZNF358,TUBG1,PWWP2B,DLEU1,GATSL3,NUP210L,CXCL16,IRF2BP2,TACC2,CDC34,IVD,ZNF404,PNPLA6,COQ9,NNAT,KCNK15,ITSN1,NCSTN,HRAS,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NPTX2,ANK2,IRS2,PKIA,EYA2,PEX6,PCSK5,RRBP1,TUBB2A,THY1,TNK2,PLOD1,CRABP1,CCDC170,TIMP4,CCND2,ASGR1,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,ASPHD2,MAP2K3,ZER1,SFRP1,MAPK7,CYR61,IFIT2,MYEOV,BOD1,DHRS4,SPTBN1,HIST1H1C,TNFSF10,IDH1,UCHL1,ID1,EFNB2,SLC2A6,SLC19A1,SH3GLB2,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ANGPT1,TWNK,TYROBP,MGMT,DPAGT1,CYP1B1,YBX2,B4GALT2,RHPN2,S100A9,LIMS1,SPRY2,CNN1,DENND1A,ZSCAN18,S1PR1,ALS2CL,CBX4,FBN2,PHLDA1,ADSSL1,DCAKD,SPHK2,CXCL12,LIPE,TPM1,SDC4,MTCH2,CYP26B1,CEL,TNIP1,ASXL2,ITGA11,TSEN54,TRIM5,PDK4,IGFBP6,STAG3L2/STAG3L3,AXIN2,TMIE,SNRK,FOXC1,PPP2R1A,C9orf9,ERCC1,PKD1,SLC22A5,PLEKHH3,AK2,NFIX,PKM,CDH23,RBBP8,ABL1,PPP1CB,TNFAIP3,RARRES1,SMPD1,HIF1A,ITGA10,CDKN2B,PRKCSH,SOX17,EPHB6,HMOX1,TMEM119,AEBP1,PCK2,CSPG4,KIT,ARHGEF2,NR2F6,CUL9,CTDNEP1,PTGER4,CXCR4,COPS7A,RNF126,SCIN,NDUFA13,FIZ1,LPAR1,ELK1,DSG2,ALG1L	836	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	malignant neoplasm of large intestine	malignant neoplasm of large intestine	2.63E-14	Increased	2.424	 	2.712	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,ACADVL,AP3M2,ING1,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,PRPH,CD209,STAMBPL1,BLMH,COL12A1,EGR1,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,DHTKD1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ZNF174,PTPRF,MAN2C1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,ANKRD20A4 (includes others),CCDC88C,SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,HELZ,SPRY1,MLF2,NLGN4X,OLFML3,FAM53B,MRPS25,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,ISM1,BZW2,TMEM8A,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,ESR1,LRRC47,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,PRKCE,NAA60,NAALAD2,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,EIF3K,EPHX1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,SPON1,DTNA,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,SYN1,GSDMC,VHL,SLC11A1,SULF1,PC,BMP2,ALDH2,ZFAND2A,EDN1,ERBB2,THBS4,NDUFV1,PATL1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,KCND2,DDX11,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,RAD23A,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,MAP1B,UNC5B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,GSK3B,GPC1,RET,HLA-F,STX11,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,APBA3,KIAA0922,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,EMILIN1,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,KLHDC8B,PAPLN,HLA-DOA,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,MAMDC2,TFPI2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,FOS,NLE1,ABCC3,ABCB6,MT2A,CH25H,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,SLF2,PTTG1,DPP7,POLR3E,PARP2,OGFOD1,STYXL1,CLPP,AP2A2,GPR4,KCNAB1,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,UNC13B,LAMA2,CLIP2,PGAP3,CAPG,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,ABCF1,STX6,CRYL1,KIFC2,GLRX,GCDH,HNRNPK,SHC1,POLR1C,DECR2,MKL2,LRPPRC,TOX2,AGT,SUGP2,PWWP2B,NQO1,LARP6,NUP210L,TUBGCP2,ANGPTL5,PMP22,CIDEA,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,C1orf115,APOB,CAMK1,DPYD,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,CACHD1,MATK,CALCRL,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,RAMP3,MAP2K3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,SRD5A1,NID2,WASF3,UHRF1BP1,XPOT,TNFSF10,MYH11,DCLK1,IDH1,UCHL1,FANCE,EFNB2,SLC2A6,STARD13,SNX10,KIAA0391,LDLRAP1,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,MGMT,CYP1B1,KRT8,PLEKHG6,TF,PPP1R16B,WAS,CDK20,ZSCAN18,ADCY1,MS4A2,S1PR1,NR5A2,CBX4,DVL3,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,CDH23,RBBP8,ABL1,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,SOX17,COL1A2,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,ZBTB7C,TRIP6,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,PLAUR,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,MTSS1,LHPP,SOGA1,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,CTHRC1,CRAT,DUSP22,TECR,COPS8,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,CPXM1,ST3GAL4,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,TPRN,ZNF598,GYPE,STAB1,NBAS,ATF3,RILPL1,TRIM35,CDC42BPB,TLN2,PLEKHF1,MATN2,VPS37A,CCPG1,C2,MAST2,ERAP2,PTGFR,FAM107A,FAM20B,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,VPS4A,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,OLFML2A,TIMP1,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,NUSAP1,PARVA,VCAM1,APBB1IP,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,TCTN1,RERGL,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PTK7,PLAT,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,C1QTNF1,PNMAL1,FUBP3,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,HEYL,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,CCT5,ACTG2,WDR4,MARCO,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,RARRES3,IDO1,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,C1QC,SLC9A1,ADCK1,ZNF263,EGR2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,CAV1,ATF4,EBF2,STK32A,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,NRDE2,IFT122,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,ZMYND19,CHDH,IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,ARHGEF16,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,WARS2,HHATL,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1712	
Cellular Movement, Skeletal and Muscular System Development and Function	cell movement	cell movement of smooth muscle cells	2.90E-14	Decreased	-2.085	 	-3.815	ADRBK1,IL6,SDC4,MYC,CAMK2D,NEO1,TXN,GSK3B,TEK,ELN,CXCL8,CALCRL,SPP1,ATF3,COMP,HBEGF,MMP2,TFPI2,ITGAM,DUSP1,RTN4,RAMP3,CYR61,mir-21,ADM,LOX,IGFBP4,APOE,FHL1,ADAMTS7,LEP,FGF2,BMP2,ADIPOQ,CDK4,TNFSF10,MEOX2,CCL3,NGF,RAMP2,VCAN,PTPRF,TRIB1,HMOX1,CCL2,TIMP1,THBS1,ENPP2,MAPKAPK2,PTGER4,PLAT,AGT,EGR1,NQO1,PLAUR,SLIT2,CYP1B1,F11R,RCAN1,PLA2G4A,LDLR,LPAR1,S1PR1,PTGS2,CXCL2,KDR,MMP9	67	
Cardiovascular System Development and Function, Tissue Development	development	development of endothelial tissue	3.15E-14	 	-0.762	 	-2.220	BMP4,KCNJ2,SERPINA3,IL6,ODC1,CYBA,SMARCB1,MGP,CAV1,VEGFD,HIPK2,HEYL,PIK3C2B,COMP,C1GALT1C1,HBEGF,THY1,MMP2,SMOC2,CDH2,CDH5,CTSB,MAP2K3,ITGA1,MAPK7,CYR61,ANG,NOTCH1,NRP1,ADM,APOE,GBP1,FGF2,SEMA6A,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,JUN,CCL2,DAB2,TNMD,PRKCE,EGFL6,CSNK2B,COL18A1,PLOD3,HEY1,PLAT,ANGPT1,ZNF580,EGR1,MESP1,AXL,GRN,F11R,PLA2G4A,S100A9,PPP1R16B,ATP6V0A2,PROCR,BMPER,PTGS2,BMP6,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,METAP2,MYC,TGFBR2,RHOB,PDCD6,GSK3B,GPC1,KLF2,TEK,PFKFB3,CXCL8,SPP1,ADAMTS1,MYDGF,STK39,EGR3,VEGFC,MYOF,STC1,ATPIF1,PRKCD,ALDH1A2,HIF1AN,FZD5,MDK,SULF1,LEP,ERN1,BMP2,PKM,HIF1A,NGF,TNFRSF12A,HMOX1,ANGPTL4,EDN1,RGS5,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,AGT,THBS4,VCAM1,G6PD,PLAUR,CSF1R,EDF1,RCAN1,COL1A1,SPARC,CXCL2,KDR,RCAN2,MMP9	128	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal cancer	intestinal cancer	3.29E-14	Increased	2.278	 	2.873	PCLO,VAC14,LRRN4CL,AJUBA,GLB1,MARCH2,SMARCB1,ETS1,SRPRA,NPR3,CDH5,PSMA4,ALCAM,SLC27A1,BRE,LTBP2,KIAA1211L,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,PDZD2,AFF3,KIF7,CBS/CBSL,ATP6V1F,TBC1D8,PIGU,AKR1C3,GMPPA,HAVCR2,NARFL,TUBA1C,NSMAF,TEK,RASGRP2,HARS2,STX1A,UBL4A,FAAP20,PSME4,NAGLU,MLKL,FAM134A,POLD2,SUN1,RAB11FIP5,CARS,ZP3,FLRT1,DENND6B,ALKBH2,HDGF,THYN1,COL6A1,CD1C,ELMOD3,FAAP100,NLRP3,PYGB,CLEC16A,BTK,ACADVL,AP3M2,ING1,MED24,CTGF,GMDS,SNTA1,CA12,HOMER3,RNF38,ZNF395,SLC22A15,FAM124B,PNKD,LSS,MCL1,TMEM39B,PIK3C2B,NAB1,ATG7,PLEC,CNOT10,PARP3,THBD,CORO7/CORO7-PAM16,MAP3K12,ISLR,GDPD5,RSAD1,KIAA0368,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CPSF2,FCGRT,ABI3BP,ZFP36,ZNF234,LEPR,EFHD1,FKBP1A,RUVBL1,MEOX2,CST3,ZNF608,COL22A1,TUB,TXNL1,AHNAK2,LIMCH1,PRPH,CD209,STAMBPL1,BLMH,COL12A1,EGR1,DDX24,RELN,COPS3,SBF1,CELF2,TMEM63B,AOX1,PTGS2,CHD7,ARID4A,C1orf186,COBLL1,LHCGR,CLEC3B,ZBTB47,CNDP2,DHTKD1,EGR3,MTURN,SLC4A7,ATP10A,ZMYND15,GPR146,ITPK1,COL6A3,FRYL,TOMM34,FPR3,ZNF174,PTPRF,MAN2C1,MARCH8,DUSP10,USP47,CYGB,SULF2,ZNF493,PLSCR4,SYBU,EMP1,EBF1,PLEKHH1,PAG1,PLP2,XK,NIPA2,CLSTN2,ANKRD20A4 (includes others),CCDC88C,SLC35C1,SUSD1,SKIV2L,OGFOD3,GNA15,LRRC28,ARHGAP39,MRPL24,CARMIL1,RUNDC3B,MAD2L2,LAMC3,OSGIN2,HAX1,WDR81,NRBP1,SLC7A10,ZNF606,PPOX,KCNIP4,ZDHHC1,AARS,FKBP2,ZDHHC4,TTLL3,IGSF1,HSD17B11,CDK4,CEBPD,GADD45GIP1,PLIN2,SOS1,ALG8,ARMCX1,RAD21,C11orf54,LIG3,SIGMAR1,HELZ,SPRY1,MLF2,NLGN4X,OLFML3,FAM53B,MRPS25,NTRK3,SERPINH1,ATP6V0A2,ARHGDIA,MAN2B1,MSRA,ISM1,BZW2,TMEM8A,SLC35F6,CD163,GPNMB,MYC,TGFBR2,RHOB,MOCOS,TMEM234,METTL5,LILRB5,NEDD4L,RPAP1,SMPDL3A,PFKFB3,FMO2,DDOST,VEGFC,CMSS1,ARSA,DCHS1,ABCA8,GIPC1,RAB26,ALDH1A2,SORCS2,FZD5,ESR1,LRRC47,PMEPA1,RBP4,SPIRE2,ZSWIM3,AUP1,NEURL4,ETV6,GFPT2,DNAJC4,COQ8A,MEX3B,CIZ1,IARS,RNLS,CANX,N4BP1,PSME3,FAM49A,NFE2L1,SH3PXD2A,SLK,XYLT2,CAT,ISG20,MAF,TRAP1,PCDH7,CDKN2C,ZKSCAN2,C1QB,HOXA9,SLC4A3,NOSIP,ABR,ABCC1,ZHX2,GUCY1A3,MMP2,SCNN1D,RAE1,DOCK1,PIP5K1C,C11orf80,TRO,BACE2,PDGFD,SCAP,VCAN,TADA3,SRGAP1,ALDH1A3,PRKCE,NAA60,NAALAD2,ACSL4,TBCD,PLOD3,DNAH6,CYP11A1,SOX7,RRP12,PCDH9,STXBP6,POLD1,POMGNT1,GLIPR2,COL5A3,CLDN5,RBM6,CHFR,DBNL,VPS52,CYP2C8,C10orf54,LARS,ADPRHL2,ACTA1,RTCA,CSF3R,SGCG,ITPR2,LMNA,TRAPPC9,PCGF1,THSD7B,DRAP1,PRDX5,HPS6,FLRT2,CHPF,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,RNF144B,SNAPC4,DLGAP4,LCLAT1,CPED1,ZBTB42,F13A1,CSF1R,PTGES3L-AARSD1,DYM,ATP6V1B2,CARM1,KCNJ2,PPP2R3B,MTG1,IL6,NPAS2,POLRMT,EIF3B,CSE1L,C6orf136,AHCY,COMP,COCH,SURF1,GFM1,PTOV1,TMEM100,PDLIM7,C15orf39,PLTP,EIF3K,EPHX1,COL4A5,PSMD7,DAPK2,GNA11,DPM2,FNTA,COL15A1,SPON1,DTNA,ZNF419,GTF3C1,UCP2,MECOM,SLC25A1,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,DEXI,RARRES2,MICALL2,ZFPM1,GPC3,CTSD,EXOSC3,ERAL1,KMT5A,CXCL8,NOX4,STXBP1,TJP2,STK39,UROS,H6PD,FIG4,ERCC2,AKR1B10,ADRA2A,FAM26F,SLC25A10,CCDC80,SYN1,GSDMC,VHL,SLC11A1,SULF1,PC,BMP2,ALDH2,ZFAND2A,EDN1,ERBB2,THBS4,NDUFV1,PATL1,RGS20,COL6A2,PACS1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,KCND2,DDX11,TYRO3,RAN,PCDH17,GHITM,POMC,PALMD,RAD23A,NR4A3,EVI5L,DMRT2,ITGA3,PLS3,AHSA1,IRX3,MGAT4B,MED16,TESK1,HADHA,CAPN5,EFL1,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,MBD2,MNDA,ROR1,NLRX1,VPS26B,BCAP29,FARSA,LARGE1,AAAS,PDE1B,RTN4,ALAS2,CAPRIN1,AKAP12,SQLE,FYN,MAP7,BTG3,CRTAP,HEATR1,TTLL4,SLC1A3,HYOU1,GOLGA3,ATAT1,NAA35,ABCA5,CORO2B,THBS3,SF3B3,EIF4EBP1,CELF1,STOM,JUN,KAT2B,ZNF334,CSF2RA,PDE3B,DCXR,MYO1D,FUK,ECM2,RBBP9,PLXNA1,ABHD5,NOL6,PTPRK,MYOM2,WDR55,CSK,BHLHE22,ARHGAP4,PAICS,NBEA,BRMS1,AXL,GBP4,PLA2G2A,OTUB1,RHBDD2,ANXA3,TM4SF1,TFF3,FARP1,CD36,CD4,MAP1B,UNC5B,PIGQ,NDUFB10,CAMK2D,SLC25A6,MYOM1,PCYT2,GSK3B,GPC1,RET,HLA-F,STX11,FUCA1,HNMT,TRIOBP,GSDMB,TALDO1,PCDHA1,GPAA1,RASD1,UBXN11,APBA3,KIAA0922,CCDC184,PRSS23,RAP1GAP,N6AMT1,CLCN7,CRABP2,DNPEP,ARL2,SPIRE1,--,SH3BP4,KIAA1191,ATF5,RRAGD,IPO9,NFKBIA,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,CHEK2,ZFP42,EMILIN1,PAK4,EPAS1,BHLHE41,OAF,SGTA,PPP1R16A,IL18RAP,NAT8L,CYC1,APOC1,EPHB3,NUCB2,GPR160,GAP43,KDR,TNFRSF19,KLHDC8B,PAPLN,HLA-DOA,CTSG,COL8A1,SERPINA3,PLEKHM2,CLIP1,FADS3,IQCC,HIPK2,KAT2A,TMEM97,VPS4B,TM6SF1,STK36,ANO6,NPY5R,MAMDC2,TFPI2,SHROOM4,HSPA8,EVPL,CBLN3,ATMIN,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,MRPL22,COL16A1,IRF2BP1,SORBS1,IL17D,TTC23,DDX28,TRIM29,POMGNT2,G3BP2,CNFN,ZNF524,PRDM11,CBR3,FOS,NLE1,ABCC3,ABCB6,MT2A,CH25H,TRAPPC2L,FOXRED1,ATP13A1,ATP2B1,SLF2,PTTG1,DPP7,POLR3E,PARP2,OGFOD1,STYXL1,CLPP,AP2A2,GPR4,KCNAB1,FAR2,PDZRN3,LACTB,KCNJ8,LRBA,MAST4,UNC13B,LAMA2,CLIP2,PGAP3,CAPG,OSBPL7,C9orf114,KCNG1,CBX1,ORM1,MRPS2,DOK5,RUNX1,PCMTD2,UBXN1,TPR,ABCF1,STX6,CRYL1,KIFC2,GLRX,GCDH,HNRNPK,SHC1,POLR1C,DECR2,MKL2,LRPPRC,TOX2,AGT,SUGP2,PWWP2B,NQO1,LARP6,NUP210L,TUBGCP2,ANGPTL5,PMP22,CIDEA,PIGB,SCARA3,TACC2,KIF5B,HEPACAM,NOP16,NREP,PARP6,CADM3,C1orf115,APOB,CAMK1,DPYD,ITSN1,DNAJB4,WDR45,TGFBR3,HRAS,PCOLCE,NEU1,PEG10,MYRIP,NPTX2,ANK2,CACHD1,MATK,CALCRL,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CD68,PTPRB,NPRL3,SPINT2,RAMP3,MAP2K3,ZER1,SFRP1,MAPK7,IFIT2,MYEOV,MME,RAB32,PIGO,ZNF330,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,MYH11,DCLK1,IDH1,UCHL1,FANCE,EFNB2,SLC2A6,STARD13,SNX10,KIAA0391,LDLRAP1,RASSF5,TPO,PCBP2,PTPRT,SF3A2,PI4KA,MYCN,VPS18,ADRM1,C5AR1,UBE2M,MGMT,CYP1B1,KRT8,PLEKHG6,TF,PPP1R16B,WAS,CDK20,ZSCAN18,ADCY1,MS4A2,S1PR1,NR5A2,CBX4,DVL3,FBN2,ADSSL1,SPHK2,IL17RC,TPM1,UTP4,TUBB,CCT8,PARVB,TNIP1,ITGA11,BRSK1,GABARAPL1,SDPR,PUSL1,SLC7A5,NEO1,PUF60,TRIM5,IGFBP6,MIF,TMIE,TEX2,SNRK,ZNF616,PKN1,EPRS,STC1,PPP2R1A,SMOX,SNX1,EXTL3,VAPA,CDH23,RBBP8,ABL1,MRPL2,TNFAIP3,SLC7A1,MYLK,SMPD1,SIL1,HIF1A,ITGA10,IRF3,ACOT7,PRKCSH,PDCD4,SOX17,COL1A2,TMEM119,NFX1,HMOX1,CSPG4,POLN,ARHGEF2,STK40,HMGCS1,ALPL,PI4KB,PRNP,CYP27A1,ZBTB7C,TRIP6,RAPGEF5,COQ2,SLC7A8,ZDHHC7,CCDC3,CYTIP,RTN3,TLE1,EEF1G,SLC39A8,PPRC1,TSC2,DEFB132,ECHDC1,WASH3P,DDIT4,SLX4,DVL2,C14orf79,TRIAP1,RAB40C,RCN3,KIAA1217,mir-21,GBP1,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,LLGL1,ATN1,EMP3,PSMB6,THNSL2,GPAM,MTHFD1L,SWAP70,MTHFSD,NDST2,CYP4F11,TRPM8,TMEM169,MYL6B,DNAJC15,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,CPNE1,ADAMTS1,SGCB,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,DBNDD1,C19orf54,C17orf97,ETV5,MRPL27,RPH3AL,MRPL15,EMX2,VPS25,F8,C16orf59,EPN1,RNF26,TCEA3,PLAUR,FRMD4A,TXNDC12,ZNF544,FECH,TSC22D1,MAP4K4,EFEMP2,SP110,PRG4,SPAG8,BIRC7,SV2B,CENPB,MT1X,COMMD9,FAHD2A,GCOM1,CHI3L2,MALSU1,APEH,FAHD2B,CCDC136,EEF2KMT,TSPAN14,ILVBL,SORL1,SIN3B,ST6GALNAC4,RNF185,CCL8,DIP2B,EGFL6,RNF135,HGS,RPS24,SLC25A13,ANKRD9,TRIM28,PGBD5,OCIAD2,NTM,ACLY,SLC2A8,CYP4F22,GPR180,PQLC2,FBXW9,SPNS1,DNAJB2,ZNF91,SLC6A16,FAM173A,PLCXD3,PLCE1,ACP6,MCTP1,NAV1,AAGAB,FAM193A,FST,CD302,ACP2,C5orf15,USP36,IRX6,ACAP1,SLC39A3,TARS,PUS1,LRRC41,CSN1S1,DUS1L,SCRIB,YIF1A,UVRAG,CDK5RAP2,UTP11,HIGD1A,MAN1B1,RAB5A,ARHGAP17,THBS1,ASAP3,ATP2C1,PARP10,C9orf3,ANKRD54,LRRK2,TANC2,CCDC85A,C16orf58,NCAPH2,RPS27L,FAM46A,MT1F,MYPOP,SLC47A1,SLIT3,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,ASCC2,ATP2A2,MT1E,ODC1,NKAP,CAAP1,GATAD2A,PPP1R3F,NUP93,GPRC5C,EFHB,PLEKHO2,WDR47,ALDH3A1,TACO1,MYL3,TSHZ2,NUP43,PDIA5,ALDH1B1,DPT,MTSS1,LHPP,SOGA1,MFAP5,RAB3IL1,REEP6,SMOC2,TRAPPC1,AEN,PYGO2,TNPO2,MN1,TMEM41B,CYP4B1,ARHGEF6,PHF23,GCC1,TFRC,CD86,P2RX6,CHD1L,SQSTM1,BYSL,IGSF10,PTPRA,NOL7,FBXO10,SLC4A2,PLXNA3,CUBN,HS2ST1,GDF15,SCUBE2,CTHRC1,CRAT,DUSP22,TECR,COPS8,KLHDC9,ASB1,AHSA2,DUSP5,POFUT2,CCL2,DAB2,ADORA1,CYP51A1,BTNL9,SLC38A7,TJP1,GLRX2,STON1,C1orf122,FAM178B,TBC1D13,ARHGEF5,SDF2L1,LY96,MYOC,ZFPM2,TPP1,BMPER,TP53BP1,TMEM139,AFG3L2,BMP6,CPXM1,ST3GAL4,ADRA1A,KTN1,MAOA,NCDN,NOC3L,SNX8,ABCA3,RTN1,ACO2,TYMP,TIGD2,IMP4,TPRN,ZNF598,GYPE,STAB1,NBAS,ATF3,RILPL1,TRIM35,CDC42BPB,TLN2,PLEKHF1,MATN2,VPS37A,CCPG1,C2,MAST2,ERAP2,PTGFR,FAM107A,FAM20B,FRZB,SRPX,SCARA5,DENND4B,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,VPS4A,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,OLFML2A,TIMP1,MCAM,LOC102724428/SIK1,ATP13A2,CCDC50,SLC20A1,NUSAP1,PARVA,VCAM1,APBB1IP,PGAP2,ST3GAL6,GNAI1,BSCL2,ATIC,SERPINE2,KCTD13,CLGN,LOC102724788/PRODH,PHF19,VAV3,SNAPC2,UBE2E2,GAPVD1,ADHFE1,MIB2,SGK1,VWA5A,NCOA7,SPTLC2,SLC16A2,VEGFD,ALPK1,MRPL4,RIMS3,GRAMD1A,UBQLN4,MRPL14,SRGAP3,PPIH,DHRS9,MAP3K20,IL10RA,ALDOA,LRP8,AIDA,ITGA7,SLC35A4,PHLPP1,ATP5G1,TCTN1,RERGL,FAXDC2,TMEM94,MTOR,TARS2,DHPS,SOCS2,LIPG,SARS,COL18A1,NCKIPSD,PTK7,PLAT,GSTM1,CCDC130,EPB41L4B,NR2C2AP,TRMT1,P4HTM,MCM2,UQCR10,ZFP36L2,MAPRE3,FZD7,MVD,PTPN23,VPS28,FNIP2,COBL,LOC102724828/MRPL23,TRIM47,CCNL1,MBNL3,SDAD1,OSR1,TMEM156,TMEM150A,KPNA2,SIAH2,CCDC86,LPIN2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,PTX3,MGRN1,APLNR,SPP1,NUP155,MACROD1,ZNF408,MYOF,MARS,PANK1,R3HDM4,RRP7A,HSPA13,LSM7,MAP2K5,COL7A1,CCDC106,AOC3,SPX,ADAMTS7,B3GALT6,LEP,NLGN1,C1QTNF1,PNMAL1,FUBP3,RPS6KB2,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,FRMD1,SPOCD1,SMAD7,ENO1,OLFML2B,LRP1B,TANGO2,NDNF,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,MMP9,SHMT2,AXIN1,PPP1R14B,BCAT2,PLXNB2,AMHR2,HEYL,ERICH1,CTSB,TUFM,HSDL1,ABCC9,KIAA1549L,ZNF521,SPATS2L,PVR,GCNA,SFMBT1,RABEP1,ANKMY1,AP1B1,CEP104,OSCP1,ZNF75D,CCT5,ACTG2,WDR4,MARCO,H19,MAN1C1,CBX6,LZTR1,EIF4E2,TXNRD1,FCN3,ZNF296,TMEM19,SLC7A2,BAP1,TNS1,IGFBP4,PLGRKT,DNASE1L3,INPPL1,COL6A6,PHLDB2,HLA-G,ESPNL,GTPBP2,SRC,POLR3B,PRUNE2,GYG2,SLC15A4,KIF21A,AFAP1,RNASEH2A,NGRN,CLEC4F,TBL3,ENAH,CLEC14A,MORN4,CEP164,CSRNP2,CCDC8,SLIT2,TMEM42,DCAF13,RBM42,BRINP2,UAP1L1,CILP,MAMSTR,LRFN4,TNFRSF4,FAT1,TCEB2,WDR5,GSPT1,ALDH3A2,BCL7C,PHPT1,BCKDK,EPB41L1,C7orf50,FERMT3,TTYH1,PTPRE,PACSIN3,ICA1,RPUSD1,HSPA9,FZD9,MAPK8IP3,FLCN,C1QTNF6,PRKCD,RARRES3,IDO1,SMAP1,SH3RF3,SLC4A11,KCTD1,NCL,MAPKAPK2,CCDC189,COL5A2,LRRC2,PCOLCE2,VSIG4,DHX37,PRMT1,PLBD2,COLEC11,TMEM2,ACAT1,GLMP,GBE1,PDE8B,CPZ,C6,DHRS7B,ANKRD35,NDUFA9,C1QC,SLC9A1,ADCK1,ZNF263,EGR2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,CAV1,ATF4,EBF2,STK32A,CDC16,UNG,PIGT,SELE,PODN,PPP1R1B,SMG5,TIMM8B,FLOT1,THOP1,RHBDD1,IFNAR2,ZNF579,CARD9,NRDE2,IFT122,CTSA,FBXW5,LRRN3,VARS2,FSCN1,NCF2,TRPC4AP,MCEE,CCDC178,ITGA1,TULP3,SLC35B4,SAMD4A,CXorf57,TOMM40,CHCHD10,GUCD1,PHLDA2,FGF2,SEMA6A,CKAP4,TOM1L2,SLC35B2,LAMP3,HS3ST3A1,TGM2,ZMYND19,CHDH,IL34,RANGAP1,OSBPL11,CSNK2B,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,NINL,MRPL12,CUL7,TOB1,SLCO2A1,TRIB3,GFRA2,AGL,HSPA2,GLG1,SNUPN,NRXN2,NR4A2,FAM129A,FLNC,GPBAR1,ATP1A2,MBD3,TAF1C,XAF1,TMEM177,AARS2,SEMA3C,CSTF3,QPCT,SESN2,SLC38A10,MBP,KLF6,C16orf91,HDAC11,GCLM,CHTF18,CHMP1A,DOK2,SRPRB,ANO1,KLF4,SLC3A2,ALG3,ARHGEF16,SOBP,LIMA1,IGFBP3,AGAP3,CAPN2,MEGF8,DOCK6,CADPS2,ENPP2,LONP1,PSAT1,SLC22A12,ZNF358,TUBG1,SMAD6,ASTN2,SMG7,RPS6KA4,IVD,ALKBH3,PNPLA6,SFXN5,AHCYL1,SGSH,NCSTN,SNAP47,RAPH1,GRWD1,SATB2,PEX16,NMUR2,GAA,IRS2,SARS2,EYA2,ARHGEF4,PEX6,PCSK5,RRBP1,TNK2,FAM129B,LDOC1,CDH12,CCND2,NR1D1,INHBE,STIP1,ADAMTS18,ADM2,ASPHD2,GLUL,CYR61,RAVER2,ADM,SPTBN1,HIST1H1C,ADAM17,MSC,GRB14,TCEA1,TTC1,RPP40,COL5A1,SEC61A1,HLCS,CLMN,SLC19A1,PSMD14,STIM1,SH3GLB2,PRPF31,MYH1,SEMA3G,STK19,ANGPT1,TWNK,IMPDH2,DPAGT1,WARS2,HHATL,B4GALT2,SUPV3L1,S100A9,COPS7B,NOP2,SPRY2,DENND1A,LSP1,BNIP3L,NEDD9,ACTR1A,EFR3A,RGS1,PHLDA1,TFG,CXCL12,XPO5,TAF10,PLEKHG4,CYP26B1,CEL,CRIP1,ASXL2,ZSWIM1,IP6K1,C14orf180,PDK4,EIF2AK1,AXIN2,DNASE2,ST6GALNAC3,EFS,C9orf9,ITGAM,ERCC1,PKD1,PLEKHH3,RNF165,EPB41L3,PKM,PPP1CB,TET1,QPRT,GPR34,FBXO3,FAM110B,EVC,NKD2,AEBP1,CCL13,KCNMA1,C7,CLOCK,KIT,NEK7,NR2F6,HCST,CUL9,PTGER4,MIPEP,MTMR14,RNF126,QSOX1,SCIN,NFKBIZ,CPA4,ARHGAP28,KIAA0930,DIP2C,LPAR1,EXOC4,JCHAIN,ELK1,DSG2	1715	
Cardiovascular System Development and Function, Tissue Development	development	development of cardiovascular tissue	3.83E-14	 	-0.986	 	-2.464	BMP4,KCNJ2,SERPINA3,IL6,ODC1,CYBA,SMARCB1,MGP,CAV1,VEGFD,HIPK2,HEYL,PIK3C2B,COMP,C1GALT1C1,THY1,HBEGF,MMP2,SMOC2,CDH2,CDH5,CTSB,MAP2K3,ITGA1,MAPK7,CYR61,ANG,NOTCH1,NRP1,ADM,APOE,GBP1,FGF2,SEMA6A,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,JUN,CCL2,DAB2,TNMD,PRKCE,EGFL6,CSNK2B,COL18A1,PLOD3,HEY1,PLAT,ANGPT1,ZNF580,EGR1,MESP1,AXL,GRN,F11R,PLA2G4A,S100A9,PPP1R16B,ATP6V0A2,PROCR,BMPER,PTGS2,BMP6,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,METAP2,MYC,TGFBR2,RHOB,PDCD6,GSK3B,GPC1,KLF2,TEK,PFKFB3,CXCL8,SPP1,ADAMTS1,MYDGF,STK39,EGR3,VEGFC,MYOF,STC1,ATPIF1,PRKCD,ALDH1A2,HIF1AN,FZD5,MDK,TMOD1,SULF1,LEP,ERN1,BMP2,PKM,HIF1A,NGF,TNFRSF12A,HMOX1,ANGPTL4,EDN1,RGS5,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,AGT,THBS4,VCAM1,G6PD,PLAUR,CSF1R,EDF1,RCAN1,COL1A1,SPARC,CXCL2,KDR,RCAN2,MMP9	129	
Connective Tissue Disorders, Skeletal and Muscular Disorders	arthropathy	arthropathy	7.99E-14	 	0.678	 	0.176	HLA-DOA,CTSG,CACNA1H,C1QA,CLSTN2,IL6,EEF1G,SLC39A8,SKIV2L,IP6K3,CCND3,LUM,ECHDC1,TNFRSF21,CERS6,PTGIS,RBM38,SELE,COMP,TNFRSF10B,IFNAR2,TFPI2,HSPA8,TMEM127,HLA-DRB4,VARS2,CTSB,TFRC,CD86,FTH1,APOE,COL4A5,GADD45B,DDIT3,FGF2,ADIPOQ,ZBTB9,C1R,CCL2,ARFGAP1,IL17D,RENBP,FCGR3A/FCGR3B,CCR1,SIGMAR1,TJP1,CD69,SPATS2L,SLCO2A1,TK2,GRN,FOS,PLA2G4A,HP,NR4A2,LDLR,LYN,TP53BP1,NDST2,ADRA1A,MAOA,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,HSPA5,CD163,TGFBR2,PADI4,CARD8,CXCL14,EEF1E1,TUBA1C,CXCL8,ADAMTS1,PPP1R11,PTGDS,FOSB,H3F3A/H3F3B,ADRA2A,DUSP1,SLC7A2,NAGLU,CAPN2,FZD5,MDK,SLC11A1,C2,RBP4,IGFBP4,SLC1A4,FRZB,BMP2,TPGS2,CCL3,GSTT1,HLA-G,HLA-DRB1,EDN1,TIMP1,SAA1,ENPP2,ERBB2,VARS,SRC,VCAM1,NLRP3,MMP28,SLC22A12,TUBG1,NQO1,PLAUR,HCG9,ATIC,CXCL16,PHF19,SMG7,SPARC,COL11A1,CXCL2,EFEMP2,MAP4K4,COX15,PRUNE2,CAMK1,CTGF,BMP4,TYRO3,ELANE,RAPH1,HSD17B8,NR4A3,LPIN1,ABCC1,TXN,WNT5B,MCL1,PPIL6,CALCRL,TUBB2A,MMP2,AQP9,TIMP4,CD68,PIP5K1C,IL10RA,MS4A7,ALDOA,GLUL,ALAS2,PDGFD,ITGA7,ANG,COL3A1,ADM,MME,SORL1,FCGRT,SQLE,SCAP,RALA,ZFP36,LEPR,NQO2,SLC1A3,TNFSF10,ST6GALNAC4,ATAT1,FKBP1A,GPC4,LYZ,MTOR,CCL3L1,CCL8,CCL3L3,CST3,SLC19A1,CD24,LBP,FUK,PLAT,IL11RA,RPS24,STK19,C5AR1,TYROBP,TRIM28,CSK,CINP,BRMS1,ACLY,AXL,POLD1,GABRE,PLA2G2A,F11R,GLIPR2,TF,S100A9,FCER1G,S1PR1,CELF2,CILP,PTGS2,VPS52,FBN2,TNFRSF4,TFG,CD36,CD4,CXCL12,IL17RC,LIPE,SDC4,NRSN2,CAMK2D,G0S2,UQCC2,LTBR,RET,ARL16,GCA,WDR46,ADRA1B,ACTA1,PHACTR3,CSF3R,MIF,HNMT,SPP1,DNASE2,CYYR1,LMO4,TPSAB1/TPSB2,GSR,C1QTNF6,ITGAM,ASIC1,CCL18,MAP2K5,ADAMTS7,LEP,NFIX,PRDX5,ERN1,ABL1,SLC7A1,TNFAIP3,SIL1,NGF,RAMP2,NELFE,EVC,HMOX1,NFKBIA,CCL13,THBS1,CFB,KIT,S100A8,MAPKAPK2,ALPL,CHEK2,PTGER4,ADRB2,PRNP,CD59,MIPEP,CXCR4,HYAL1,VSIG4,ZBTB42,LRRK2,F13A1,CSF1R,FAF1,ENO1,DIP2C,LRP1B,DYM,UBA1,C6,KDR,P2RX7,MMP9	287	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	inflammation	inflammation of joint	1.10E-13	 	0.842	 	0.325	HLA-DOA,CTSG,CACNA1H,C1QA,CLSTN2,IL6,EEF1G,SLC39A8,SKIV2L,IP6K3,CCND3,LUM,ECHDC1,TNFRSF21,CERS6,PTGIS,RBM38,SELE,COMP,TNFRSF10B,IFNAR2,TFPI2,HSPA8,TMEM127,HLA-DRB4,VARS2,CTSB,TFRC,CD86,FTH1,APOE,COL4A5,GADD45B,DDIT3,FGF2,ADIPOQ,ZBTB9,C1R,CCL2,ARFGAP1,IL17D,RENBP,FCGR3A/FCGR3B,CCR1,SIGMAR1,TJP1,CD69,SPATS2L,TK2,GRN,FOS,PLA2G4A,HP,NR4A2,LDLR,LYN,TP53BP1,NDST2,ADRA1A,MAOA,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,HSPA5,CD163,TGFBR2,PADI4,CARD8,CXCL14,EEF1E1,TUBA1C,CXCL8,ADAMTS1,PPP1R11,PTGDS,FOSB,H3F3A/H3F3B,ADRA2A,DUSP1,SLC7A2,NAGLU,CAPN2,FZD5,MDK,SLC11A1,C2,RBP4,IGFBP4,SLC1A4,FRZB,BMP2,TPGS2,CCL3,GSTT1,HLA-G,HLA-DRB1,EDN1,TIMP1,SAA1,ENPP2,ERBB2,VARS,SRC,VCAM1,NLRP3,MMP28,SLC22A12,TUBG1,NQO1,PLAUR,HCG9,ATIC,CXCL16,PHF19,SMG7,SPARC,COL11A1,CXCL2,EFEMP2,MAP4K4,COX15,PRUNE2,CAMK1,BMP4,CTGF,TYRO3,ELANE,RAPH1,HSD17B8,NR4A3,LPIN1,ABCC1,TXN,WNT5B,MCL1,PPIL6,CALCRL,TUBB2A,MMP2,AQP9,TIMP4,CD68,IL10RA,MS4A7,ALDOA,GLUL,ALAS2,PDGFD,ITGA7,ANG,COL3A1,ADM,MME,SORL1,FCGRT,SQLE,SCAP,RALA,ZFP36,LEPR,NQO2,SLC1A3,TNFSF10,ST6GALNAC4,ATAT1,FKBP1A,GPC4,LYZ,MTOR,CCL3L1,CCL8,CCL3L3,CST3,SLC19A1,CD24,LBP,FUK,PLAT,IL11RA,RPS24,STK19,C5AR1,TYROBP,TRIM28,CSK,CINP,BRMS1,ACLY,AXL,POLD1,GABRE,PLA2G2A,F11R,GLIPR2,TF,S100A9,FCER1G,S1PR1,CELF2,CILP,PTGS2,VPS52,TNFRSF4,TFG,CD36,CD4,CXCL12,IL17RC,LIPE,SDC4,NRSN2,CAMK2D,G0S2,UQCC2,LTBR,RET,ARL16,GCA,WDR46,ADRA1B,ACTA1,PHACTR3,CSF3R,MIF,HNMT,SPP1,DNASE2,CYYR1,LMO4,TPSAB1/TPSB2,GSR,C1QTNF6,ITGAM,ASIC1,CCL18,MAP2K5,ADAMTS7,LEP,NFIX,PRDX5,ERN1,ABL1,SLC7A1,TNFAIP3,SIL1,NGF,RAMP2,NELFE,EVC,HMOX1,NFKBIA,CCL13,THBS1,CFB,KIT,S100A8,MAPKAPK2,ALPL,CHEK2,PTGER4,ADRB2,PRNP,CD59,MIPEP,CXCR4,HYAL1,LRRK2,VSIG4,F13A1,CSF1R,FAF1,ENO1,DIP2C,LRP1B,DYM,C6,KDR,P2RX7,MMP9	282	
Cancer, Organismal Injury and Abnormalities	adenoma	adenoma	1.58E-13	 	-0.510	bias	0.692	SLIT3,CBX7,C1orf115,AXIN1,CMTM4,ASS1,CA12,HRAS,CDKN2C,POMC,ACP5,GTF2IRD1,ODC1,MIA,CCND3,AJUBA,KEAP1,TSC2,MGP,UNG,TSHZ2,ALDOC,PTGIS,DPT,ATG7,MFAP5,TUBB2A,DKC1,THY1,HMGA1,PARP3,TFPI2,PLAG1,MRPL17,CTSB,SPINT2,TRO,GLUL,LRP8,BACE2,BYSL,NOTCH1,mir-21,SPTBN1,HIST2H2AA3/HIST2H2AA4,APOE,HIST1H1C,GSTM5,LEPR,PAM16,CEBPD,CDK4,ADIPOQ,RUVBL1,COL15A1,EIF4EBP1,TGM2,DTNA,ID1,MTOR,GADD45A,ANXA5,CMTM8,DAP3,CLMN,CD24,DAB2,TPO,PTPRT,RAD21,CCDC68,MECOM,EGR1,MGMT,DGAT2,TRIB3,SLIT2,RELN,POLD1,CYP1B1,PLA2G2A,FOS,HP,ZFPM2,SLC48A1,ATP6V1F,ANXA3,NR5A2,SOX9,NLE1,PTGS2,SEMA3C,ID4,LIG1,PHLDA1,PTTG1,DPYSL4,PARP2,NTMT1,CLEC3B,RGCC,LHCGR,RNASE1,CES2,MYC,TGFBR2,GPX3,DHTKD1,SLC7A5,GSK3B,PDK4,SMPDL3A,AXIN2,SPP1,H19,STX1A,ERCC2,C9orf16,BCL2L1,PPP2R1A,SORD,ABCA8,ALDH1A2,SLC22A5,SCRIB,BAP1,ESR1,CCDC80,VHL,UBE2I,RBP4,IGFBP4,LEP,EPB41L3,SCARA5,DNASE1L3,FLRT2,PKM,CDKN2B,EPHB6,POLR1C,HMOX1,ALDH2,AEBP1,HINT1,RGS5,TIMP1,THBS1,MCAM,SMO,KIT,HSD11B2,ARHGEF2,S100A8,ERBB2,RNF144B,ASAP3,CHEK2,PSAT1,SRC,VCAM1,NUSAP1,ATP2C1,SLC12A2,VSIG4,LRRK2,C2orf88,LPAR1,JCHAIN,PAG1,VAV3,LPAR5,EPHB3,ITM2C,RDH5,MMP9	176	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of myeloid cells	2.27E-13	 	-0.323	 	-2.958	CTGF,ELANE,CTSG,HRAS,MST1,SERPINA3,POMC,IL6,SPI1,HOXA9,LUM,CAV1,VEGFD,TXN,TNFRSF21,CMKLR1,SELE,NDRG1,PLEC,ANO6,FLOT1,THBD,NINJ1,AQP9,PIP5K1C,YARS,MS4A4A,PPP1R15A,CTSB,RTN4,ITGA1,SFRP1,PLTP,CYR61,ADM,CNN2,APOE,FYN,ADAM17,DAPK2,NQO2,GDF15,ADIPOQ,G6PC3,VCAN,TGM2,MTOR,CES1,GBA,CCL3L1,CCL8,CCL2,CCL3L3,CST3,CSF2RA,STIM1,LBP,ADORA1,HCAR2,GJB2,PLAT,CCR1,C5AR1,ANGPT1,TYROBP,CD69,CSK,DEFB1,SLIT2,PVR,GRN,F11R,PLA2G4A,HP,SWAP70,LDLR,S100A9,WAS,LSP1,LYN,FCER1G,S1PR1,PROCR,MAP3K8,PTGS2,QPCT,SOCS3,RARRES2,PFN1,ADRBK1,CD36,CD4,UNC5B,SPHK2,CXCL12,HARS,TGFBR2,RSPO3,IKBKG,RHOB,PLA2G5,CXCL14,NEO1,STAB1,C1QBP,CAST,CSF3R,PTX3,ELN,CXCL8,MIF,SPP1,VEGFC,CAPG,PTGDS,TPSAB1/TPSB2,APBA3,STC1,ITGAM,DUSP1,PRKCD,IGFBP3,CD14,MDK,C2,AOC3,SFTPD,LITAF,LEP,ABL1,TNFAIP3,MYLK,HIF1A,NGF,CCL3,HMOX1,CD55,NFKBIA,CCL13,EDN1,TIMP1,THBS1,FLNA,MCAM,DUSP10,SAA1,CFB,KIT,S100A8,ERBB2,MAPKAPK2,PRNP,AGT,THBS4,VCAM1,NLRP3,EPAS1,MMP28,CXCR4,PCOLCE2,NQO1,HYAL1,SMAD7,LRRK2,PLAUR,NFKBIZ,CSF1R,BTK,COL1A1,VAV3,EDNRA,C6,KDR,CXCL2,NCKAP1L,P2RX7,MMP9	177	
Inflammatory Response	inflammatory response	inflammatory response	2.77E-13	 	-0.295	 	-2.591	CTSG,SERPINA3,IL6,SPI1,SLC9A1,CYBA,LUM,CAV1,CERS6,PTGIS,ETS1,SELE,ANO6,FLOT1,CTSB,ITGA1,mir-21,ABHD12,APOE,DDIT3,DAPK2,FGF2,SLC1A5,GNA11,ACKR2,ADIPOQ,CEBPD,G6PC3,TGM2,CCL2,GADD45A,PLIN2,IL34,ADORA1,HCAR2,CCR1,MECOM,ZNF580,CD69,CDO1,GRN,FOS,PLA2G4A,HP,LY96,SWAP70,NR4A2,LDLR,LYN,PROCR,MSRA,CYP4F11,SOCS3,RARRES2,HAVCR2,CD163,ADGRF5,RHOB,MAP2K2,CXCL14,NUPR1,BIRC3,TEK,MARCO,ELN,CXCL8,NOX4,ATF3,MYDGF,STK39,VEGFC,CAPG,GNAZ,KLF4,CRHBP,ORM1,ADRA2A,SLC7A2,MDK,ESR1,SLC11A1,LITAF,SFTPD,FEM1A,SCARA5,ZP3,ABCF1,CCL3,IRAK1,HLA-G,SHC1,EDN1,SAA1,ERBB2,AGT,THBS4,SRC,VCAM1,NLRP3,MMP28,PLAUR,TNFRSF14,NFE2L1,CXCL16,VAV3,CXCL2,TYRO3,MAF,ELANE,MST1,POMC,HOXA9,ABR,ABCC1,VEGFD,TXN,MCL1,CALCRL,CMKLR1,ATG7,PLEC,MMP2,IER3,THBD,NLRX1,NINJ1,PLAA,S1PR3,AQP9,NR1D1,YARS,PIP5K1C,IL10RA,MAP2K3,SFRP1,MAPK7,NOTCH1,FYN,ADAM17,ZFP36,FKBP1A,CASP4,LYZ,CCL3L1,CCL8,CCL3L3,CSF2RA,CST3,PRKCE,STIM1,LBP,COL18A1,PLAT,CD276,C5AR1,ANGPT1,TYROBP,EGR1,DEFB1,SLIT2,AXL,PLA2G2A,F11R,S100A9,WAS,LSP1,PELI1,FCER1G,MS4A2,S1PR1,AOX1,PTGS2,NEDD9,RGS1,TNFRSF4,PFN1,ADRBK1,CD36,CD4,SPHK2,CXCL12,SDC4,CYP26B1,IKBKG,TNIP1,C1QBP,EIF2AK1,PTX3,CSF3R,MIF,SPP1,SHARPIN,TPSAB1/TPSB2,EFS,ITGAM,RAP1GAP,PRKCD,CD14,IDO1,CLCN7,CCL18,UVRAG,AOC3,LEP,PRDX5,ERN1,TNFAIP3,MYLK,NGF,TNFRSF12A,HMOX1,NFX1,ANGPTL4,CCL13,THBS1,CSPG4,DUSP10,CLOCK,KIT,S100A8,NCL,MAPKAPK2,PTGER4,ADRB2,PRNP,EPAS1,CXCR4,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,IL18RAP,EDNRA,C6,NCKAP1L,KDR,P2RX7,MMP9	239	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of tumor cells	3.02E-13	 	0.764	 	-0.481	BMP4,ELANE,CA12,HRAS,MST1,TLE1,IL6,SPI1,ODC1,PEG10,CCND3,TSC2,LUM,ANK2,CAV1,AHCY,ATG7,NDRG1,GFM1,HBEGF,PYGO2,DVL2,CDH5,BSG,BTG2,CTSB,ITGA1,SFRP1,SQSTM1,CYR61,NOTCH1,DUS2,PTPRA,mir-21,NRP1,FHL1,DDIT3,ZFP36,FGF2,GDF15,CDK4,ADIPOQ,TNFSF10,RUVBL1,TAX1BP3,VCAN,EIF4EBP1,UCHL1,ID1,MTOR,JUN,CST3,CSF2RA,PRKCE,ACVR1C,PLAT,FCER2,MYCN,SOX7,EGR1,MGMT,ACLY,ID3,GRN,FOS,NR4A2,S100A9,PROCR,PTGS2,PIN1,SOCS3,TFF3,TNFRSF4,TFG,ADRBK1,HSPA1A/HSPA1B,SPHK2,CXCL12,DIRAS1,HSPA5,GPC3,MYC,TGFBR2,PLCE1,RHOB,GSK3B,GPC1,RET,CSF3R,PFKFB3,CXCL8,NOX4,MIF,PTPRE,FST,ATF3,SPP1,BAMBI,VEGFC,INHBB,SLC3A2,SRSF3,BCL2L1,CBX1,NOL3,DUSP1,PRKCD,APCDD1,IGFBP3,RGN,CCL18,AKR1B1,ESR1,MAP2K5,LOX,LITAF,LEP,SFRP2,BMP2,ABL1,EMX2,IRF3,HIF1A,NGF,CCL3,CDKN2B,NELFE,HDGF,HMOX1,ZMAT3,NFKBIA,EDN1,TIMP1,THBS1,MCAM,SMO,KIT,ERBB2,SEMA3B,MCRS1,NDUFAF3,AGT,BEX2,SRC,COX17,CXCR4,LRRK2,PLAUR,CSF1R,BTK,RCAN1,KDR,EFEMP2,MMP9	154	
Cell Death and Survival	cell death	cell death of connective tissue cells	4.17E-13	 	-0.345	 	-0.811	EIF3C,BMP4,ITSN1,AXIN1,HRAS,CDKN2C,SH3GLB1,EIF6,SLC9A1,COMMD4,SGPL1,EGR2,EIF3B,RARA,ABCC1,SMARCB1,TSC2,LUM,ATF4,DNAJA3,TXN,HIPK2,UNG,MCL1,ETS1,SFRP4,COMP,ATG7,DDIT4,FANCG,TNFRSF10B,HBEGF,IER3,NLRX1,RAD51D,IFNAR2,GPX7,PPP1R15A,CTSB,RTN4,MAP2K3,SFRP1,CYR61,PDGFD,NOTCH1,mir-21,FTH1,EPHX1,ADM,FYN,GADD45B,DDIT3,GSTM5,FGF2,CDK4,ADIPOQ,TNFSF10,CASP4,FNTA,DDX3X,EIF4EBP1,DIABLO,TGM2,EFNB2,CA3,ID1,MTOR,JUN,RASSF5,PIK3R2,TRIM29,ATN1,MAPKAP1,MECOM,EGR1,CUL7,IGF2R,CYP1B1,GRN,PLA2G4A,LAMP2,KRT8,NR4A2,DHCR24,SERPINH1,BMF,S1PR1,FKBP4,TPP1,BNIP3L,MAP3K8,PIN1,LIG1,ADRBK1,VPS28,CD36,CA4,DPYSL4,PARP2,KLF6,UNC5B,SPHK2,LIPE,SDC4,HSPA5,MYC,CTSD,TNIP1,IKBKG,RHOB,NUPR1,GSK3B,NSMAF,BIRC3,KLF2,EIF2AK1,CXCL8,ATF3,SPP1,SHARPIN,GNG2,LMNA,PAWR,STX1A,STC1,BCL2L1,PKD1,PLEKHF1,DUSP1,PRKCD,IGFBP3,GNL3,PIDD1,ESR1,VHL,MLKL,S100P,SUN1,TNFAIP8,RUNX1,LEP,SFRP2,CDC20,FRZB,ATF5,NELFB,BMP2,ABL1,TNFAIP3,SMPD1,ATF6,IRF3,HIF1A,NGF,HMOX1,HINT1,NFKBIA,STUB1,TIMP1,FLNA,SAA1,SMO,RPS6KB2,HSD11B2,S100A8,ERBB2,CUL9,PI4KB,PRNP,AGT,FAAH,SRC,NLRP3,PERP,EMD,TRIP6,CSF1R,NFE2L1,SLK,FAF1,ENO1,CIDEA,CAPNS1,RRAS2,CAT,UBA1,ELK1,YME1L1,DNM1L,MMP9	190	
Cellular Movement	cell movement	cell movement of muscle cells	4.24E-13	Decreased	-2.085	 	-3.823	ADRBK1,ITGB1BP1,IL6,SDC4,MYC,CAMK2D,NEO1,TXN,GSK3B,TEK,ELN,CXCL8,CALCRL,SPP1,ATF3,COMP,HBEGF,MMP2,TFPI2,ITGAM,DUSP1,RTN4,RAMP3,CYR61,mir-21,ADM,LOX,IGFBP4,APOE,FHL1,ADAMTS7,LEP,FGF2,BMP2,ADIPOQ,CDK4,TNFSF10,MEOX2,CCL3,NGF,RAMP2,VCAN,PTPRF,TRIB1,HMOX1,CCL2,TIMP1,THBS1,NET1,SMO,ENPP2,MAPKAPK2,PTGER4,PLAT,AGT,THBS4,EGR1,NQO1,PLAUR,SLIT2,CYP1B1,F11R,RCAN1,PLA2G4A,LDLR,LPAR1,S1PR1,PTGS2,CXCL2,KDR,MMP9	71	
Cardiovascular System Development and Function, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Organismal Development, Tissue Development	development	endothelial cell development	4.69E-13	 	-0.695	 	-2.164	BMP4,KCNJ2,SERPINA3,IL6,ODC1,CYBA,MGP,CAV1,VEGFD,HIPK2,HEYL,PIK3C2B,COMP,C1GALT1C1,HBEGF,THY1,MMP2,SMOC2,CDH2,CDH5,CTSB,ITGA1,MAP2K3,MAPK7,CYR61,ANG,NOTCH1,NRP1,ADM,APOE,GBP1,FGF2,SEMA6A,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,JUN,CCL2,DAB2,TNMD,PRKCE,EGFL6,COL18A1,PLOD3,HEY1,ANGPT1,ZNF580,EGR1,MESP1,AXL,GRN,F11R,PLA2G4A,S100A9,PPP1R16B,ATP6V0A2,PROCR,BMPER,PTGS2,BMP6,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,METAP2,MYC,TGFBR2,PDCD6,GSK3B,GPC1,KLF2,TEK,CXCL8,PFKFB3,ADAMTS1,MYDGF,STK39,EGR3,VEGFC,MYOF,STC1,ATPIF1,PRKCD,ALDH1A2,HIF1AN,FZD5,MDK,SULF1,LEP,ERN1,BMP2,PKM,HIF1A,NGF,TNFRSF12A,HMOX1,ANGPTL4,EDN1,RGS5,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,AGT,THBS4,VCAM1,G6PD,PLAUR,CSF1R,EDF1,RCAN1,COL1A1,SPARC,CXCL2,KDR,RCAN2,MMP9	123	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	morphology	morphology of heart	5.52E-13	 	 	 	 	APOB,TGFBR3,RRM2B,CACNA1H,NCSTN,CDKN2C,IL6,ATP2A2,POR,IDUA,CCND3,GAA,RARA,LUM,CAV1,HEY2,HADHA,CASQ2,HEYL,CALCRL,PLEC,HBEGF,MMP2,HMGA1,IER3,THBD,GPX7,DOCK1,DVL2,CDH2,IFT122,TIMP4,CCND2,CDH5,MAP2K3,MAPK7,NOTCH1,ADM,SPTBN1,AKAP12,HIST1H1C,APOE,ADAM17,FGF2,ADIPOQ,CDK4,FKBP1A,MYH11,TGM2,EFNB2,JUN,LY6E,GNG5,COL18A1,CYP51A1,HEY1,MYCN,MECOM,MESP1,SLCO2A1,TK2,IGF2R,PLA2G4A,ZFPM2,LDLR,NTRK3,DVL3,SGCD,ADRBK1,CD36,PLA2G15,GPC3,BIN1,MYC,TGFBR2,RSPO3,PLCE1,OSR1,RET,BIRC3,ADRA1B,TEK,EIF2AK1,ELN,NOX4,PKP2,SGCG,LMNA,DCHS1,BCL2L1,NOL3,ALDH1A2,CAPN2,MEGF8,TMOD1,TXNRD2,RBP4,FLRT2,ABL1,HIF1A,RAMP2,ETV6,CIAPIN1,HMOX1,SHC1,EDN1,THBS1,FLNA,SMO,MKL2,RPS6KB2,ERBB2,HMGCL,ACADM,PTGER4,VCAM1,PAK4,DHRS3,EPN1,CXCR4,MTMR14,SMAD7,G6PD,EMD,SNX27,BSCL2,KIF3B,RCAN1,ITPA,ACADVL,VAV3,EDNRA,GBE1,RCAN2,MMP9	135	
Tissue Development	development	development of epithelial tissue	7.17E-13	 	-0.000	 	-1.728	CTGF,BMP4,KCNJ2,HRAS,MST1,SERPINA3,IL6,ODC1,HOXA9,CYBA,SMARCB1,MGP,CAV1,VEGFD,HIPK2,PIK3C2B,HEYL,COMP,C1GALT1C1,THY1,HBEGF,MMP2,SMOC2,CDH2,CDH5,CTSB,MAP2K3,ITGA1,MAPK7,CYR61,NOTCH1,ANG,NRP1,ADM,MAP7,APOE,NME1,COL4A5,GBP1,LEPR,FGF2,PSMB10,SEMA6A,ADIPOQ,TNFSF10,MEOX2,EFNB2,ID1,MTOR,JUN,CCL2,TNMD,PRKCE,DAB2,EGFL6,CSNK2B,COL18A1,GJB2,PLOD3,HEY1,PLAT,MYCN,ADRM1,ANGPT1,ZNF580,EGR1,MESP1,SLIT2,AXL,GRN,F11R,PLA2G4A,KRT8,S100A9,PPP1R16B,SPRY2,ATP6V0A2,PROCR,SOX9,BMPER,PTGS2,PIN1,BMP6,CHD7,CD36,PTTG1,ITGB1BP1,ABCA3,RGCC,CXCL12,SDC4,CEP104,METAP2,MYC,TGFBR2,RHOB,PDCD6,GSK3B,GPC1,LTBR,KLF2,TEK,ELN,PFKFB3,CXCL8,SPP1,ADAMTS1,MYDGF,STK39,EGR3,RILPL1,VEGFC,MYOF,KLF4,INHBB,STC1,ATPIF1,PKD1,PRKCD,ALDH1A2,SOBP,HIF1AN,SCRIB,FZD5,MDK,ESR1,SULF1,LEP,ERN1,BMP2,PKM,HIF1A,NGF,TNFRSF12A,HMOX1,NFKBIA,ANGPTL4,EDN1,RGS5,TIMP1,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,SULF2,ASIP,AGT,THBS4,VCAM1,CXCR4,G6PD,PLAUR,NUP210L,CSF1R,EDF1,COL1A1,RCAN1,XYLT2,RRAS2,SPARC,KDR,CXCL2,RCAN2,MPV17,MMP9	167	
Cell Death and Survival	cell death	cell death of endothelial cells	8.70E-13	 	0.451	 	0.489	ISM1,ITSN1,CD36,ASS1,CXCL12,HRAS,SERPINA3,ARG2,TYMP,IL6,HSPA5,MYC,NR4A3,ITGA3,IKBKG,RHOB,PLA2G5,LUM,CAV1,TXN,GSK3B,KLF2,CXCL8,HEYL,MIF,COMP,SPP1,ATF3,ADAMTS1,TNFRSF10B,MMP2,THBD,BCL2L1,CDH5,HIF1AN,IGFBP3,MAP2K3,MAPK7,mir-21,RBP4,ADM,ADAM17,LEP,DDIT3,PSMB10,ERN1,FGF2,SEMA6A,ABL1,ADIPOQ,TNFSF10,TNFAIP3,SMPD1,MEOX2,HMOX1,ALDH2,NFKBIA,EDN1,RGS5,THBS1,MCAM,PRKCE,S100A8,SEMA3B,COL18A1,MAPKAPK2,PLAT,AGT,SRC,UCP2,ANGPT1,CXCR4,AXL,CAT,PROCR,KDR,MMP9	77	
Connective Tissue Disorders, Inflammatory Disease, Skeletal and Muscular Disorders	rheumatic disease	Rheumatic Disease	9.16E-13	 	0.865	 	0.529	HCAR3,HLA-DOA,CTSG,CACNA1H,C1QA,CLSTN2,IL6,EEF1G,SLC39A8,SKIV2L,IP6K3,EGR2,CCND3,LUM,ECHDC1,TNFRSF21,CERS6,PTGIS,RBM38,SELE,COMP,TNFRSF10B,IFNAR2,TFPI2,HSPA8,TMEM127,CTSA,HLA-DRB4,VARS2,NCF2,CTSB,TFRC,CD86,mir-21,FTH1,APOE,COL4A5,GADD45B,DDIT3,FGF2,ADIPOQ,ZBTB9,C1R,CCL2,ARFGAP1,IL17D,LY6E,RENBP,FCGR3A/FCGR3B,CCR1,SIGMAR1,TJP1,CD69,SPATS2L,TK2,GRN,FOS,PLA2G4A,HP,NR4A2,LDLR,LYN,MAP3K8,TP53BP1,NDST2,ADRA1A,MAOA,MT2A,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,HSPA5,CD163,TGFBR2,PADI4,CARD8,CXCL14,EEF1E1,TUBA1C,CXCL8,ADAMTS1,PPP1R11,PTGDS,FOSB,BCL2L1,H3F3A/H3F3B,ADRA2A,DUSP1,SLC7A2,NAGLU,CAPN2,FZD5,MDK,ESR1,SLC11A1,C2,RBP4,IGFBP4,SLC1A4,FRZB,DNASE1L3,BMP2,TPGS2,CCL3,GSTT1,HLA-G,HLA-DRB1,EDN1,TIMP1,SAA1,ENPP2,ERBB2,CD1C,VARS,SRC,VCAM1,NLRP3,MMP28,SLC22A12,TUBG1,NQO1,PLAUR,HCG9,ATIC,CXCL16,PHF19,SMG7,SPARC,COL11A1,CXCL2,EFEMP2,MAP4K4,COX15,PRUNE2,CAMK1,CTGF,BMP4,SGK1,TYRO3,ELANE,POMC,C1QB,RAPH1,GSS,HSD17B8,NR4A3,LPIN1,ABCC1,TXN,WNT5B,MCL1,PPIL6,CALCRL,TUBB2A,MMP2,AQP9,TIMP4,CD68,MS4A7,IL10RA,ALDOA,GLUL,ALAS2,PDGFD,ITGA7,ANG,COL3A1,ADM,MME,SORL1,FCGRT,SQLE,SCAP,ADAM17,RALA,ZFP36,LEPR,NQO2,SLC1A3,TNFSF10,ST6GALNAC4,FKBP1A,ATAT1,GPC4,ASNS,MTOR,LYZ,CCL3L1,CCL8,CCL3L3,CST3,SLC19A1,CD24,LBP,FUK,PLAT,IL11RA,RPS24,STK19,C5AR1,TYROBP,IMPDH2,TRIM28,CSK,CINP,BRMS1,ACLY,AXL,POLD1,GABRE,PLA2G2A,GLIPR2,F11R,TF,S100A9,FCER1G,S1PR1,CELF2,CILP,PTGS2,VPS52,RGS1,TNFRSF4,TFG,CD36,CD4,CXCL12,IL17RC,LIPE,SDC4,NRSN2,CAMK2D,G0S2,UQCC2,NMNAT2,LTBR,RET,ARL16,GCA,ACTA1,WDR46,ADRA1B,PHACTR3,CSF3R,MIF,HNMT,SPP1,DNASE2,LMO4,ICA1,CYYR1,EGR3,TPSAB1/TPSB2,GSR,SRSF3,C1QTNF6,ITGAM,ASIC1,IDO1,CCL18,MAP2K5,FPR3,ADAMTS7,LEP,NFIX,PRDX5,ERN1,ABL1,SLC7A1,TNFAIP3,UBASH3B,SIL1,NGF,RAMP2,NELFE,EVC,HMOX1,RAB5A,NFKBIA,CCL13,THBS1,DKK3,HSPE1,CFB,KIT,S100A8,IFRD1,MAPKAPK2,ALPL,CHEK2,PTGER4,ADRB2,PRNP,CD59,MIPEP,CXCR4,HYAL1,VSIG4,LRRK2,F13A1,CSF1R,FAF1,COL1A1,ENO1,ITPA,DIP2C,LRP1B,DYM,EDNRA,C6,KDR,P2RX7,MMP9	316	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	abnormal morphology	abnormal morphology of heart	9.20E-13	 	 	 	 	TGFBR3,RRM2B,CACNA1H,NCSTN,CDKN2C,IL6,ATP2A2,POR,IDUA,CCND3,GAA,RARA,LUM,CAV1,HEY2,HADHA,CASQ2,CALCRL,PLEC,HBEGF,MMP2,HMGA1,IER3,THBD,GPX7,DOCK1,DVL2,CDH2,IFT122,TIMP4,CCND2,CDH5,MAPK7,NOTCH1,ADM,SPTBN1,AKAP12,HIST1H1C,APOE,ADAM17,FGF2,ADIPOQ,CDK4,FKBP1A,MYH11,TGM2,EFNB2,JUN,LY6E,COL18A1,CYP51A1,HEY1,MYCN,MECOM,MESP1,SLCO2A1,TK2,IGF2R,PLA2G4A,ZFPM2,NTRK3,DVL3,SGCD,ADRBK1,CD36,PLA2G15,GPC3,BIN1,MYC,TGFBR2,RSPO3,PLCE1,OSR1,RET,BIRC3,ADRA1B,TEK,EIF2AK1,ELN,NOX4,PKP2,SGCG,LMNA,DCHS1,NOL3,ALDH1A2,CAPN2,MEGF8,TXNRD2,RBP4,FLRT2,ABL1,HIF1A,RAMP2,ETV6,CIAPIN1,HMOX1,SHC1,EDN1,FLNA,THBS1,SMO,MKL2,RPS6KB2,ERBB2,HMGCL,ACADM,PTGER4,VCAM1,PAK4,DHRS3,EPN1,CXCR4,MTMR14,SMAD7,G6PD,EMD,SNX27,BSCL2,KIF3B,RCAN1,ITPA,ACADVL,VAV3,EDNRA,GBE1,RCAN2,MMP9	128	
Cardiovascular Disease	hypertension	Hypertension	1.04E-12	 	0.502	 	1.686	SLIT3,CBX7,MAP6,CA5B,CACNA1H,COL8A1,IL6,ATP2A2,SLC9A1,SLC39A8,CYBA,MARCH2,MGP,CAV1,EARS2,TMEM97,PTGIS,SELE,KIAA1147,RANBP3,MSMO1,SMOC2,NPR3,PRELP,ATMIN,SAMD4A,MUSTN1,FKBP2,EPHX1,APOE,FHL1,GDF15,ADIPOQ,G6PC3,COL16A1,CCL2,OSBPL11,ALG8,ABCC9,MECOM,APBB3,AFF3,MYOC,LDLR,NTRK3,RBP5,MXRA5,SGCD,HAGH,ADRA1A,MAOA,RARRES2,ATP2B1,CA4,ADGRF5,MOCOS,ACTG2,NEDD4L,ELN,NOX4,FMO2,STK39,SRPRB,VEGFC,OSBPL7,PTGDS,DCHS1,BCL2L1,ADRA2A,DNAJB6,ESR1,DOCK6,PMEPA1,TEF,PTGFR,SRPX,KCNK3,TPR,ATF6,SLC19A3,SHC1,MSRB3,F8,EDN1,OLFML2A,TIMP1,AGT,GJA4,CCDC50,VCAM1,MMP28,SLC12A2,SNTB1,FAM49A,PMP22,POLR3B,VAV3,DNAJB11,SPARC,ALKBH3,APOB,BMP4,ITSN1,CA12,ADGRL1,CLCNKA,NPTX2,IRS2,SARS2,MCL1,APTX,RASL10B,GUCY1A3,DBP,HIGD1B,SCNN1D,THBD,CREB5,CCDC136,VKORC1,PDE1B,ADM,GSTM5,LEPR,FKBP1A,TNFSF10,TRPT1,FAXDC2,GPIHBP1,KLF9,CA3,MTOR,CST3,CSF2RA,PDE3B,CLEC14A,NAALAD2,ABHD4,PLAT,CYP11A1,CEP164,ANGPT1,COL12A1,CCDC8,PLA2G2A,LMO3,PTGS2,ADRBK1,LHCGR,PLEKHG4,TMED5,RSPO3,ITGA11,COMT,ALDH3A2,PLA2G5,RET,MYO10,ADRA1B,MIF,APLNR,C3orf18,PPP1R14A,FOXC1,GSR,MMP23B,ASIC1,TMOD1,AOC3,LEP,NFIX,NLGN1,ABL1,UBASH3B,HIF1A,NGF,HMOX1,TMEM119,XPNPEP2,KIAA0040,KIT,HSD11B2,NSMF,ALPL,MYO16,ADRB2,SPOCD1,EPAS1,ATP2C1,CXCR4,DAAM2,CCDC85A,PLSCR4,CSF1R,TRIM69,CIART,PBX3,OLFML2B,NUCB2,EDNRA,RDH5,KDR,MMP9	203	
Cell Morphology	morphology	morphology of cells	1.10E-12	 	 	 	 	SLC6A9,AXIN1,C1QA,IL6,IDUA,CCND3,GLB1,TSC2,SMARCB1,PLXNB2,AMHR2,ETS1,HEYL,RBM38,CLEC4G,SURF1,DVL2,CDH5,NPR3,CTSB,mir-21,LTBP2,EIF4EBP2,GNA11,ADIPOQ,HEXA,COL15A1,SYNM,DTNA,MECOM,ZNF521,TK2,IGF2R,ID3,CSTB,MYO5A,CBS/CBSL,ATP6V1F,LYN,SOX9,NDST2,LIG1,SOCS3,DPYSL4,ZFPM1,PNRC2,CTSD,TEK,MARCO,CXCL8,NOX4,TJP2,MAN1C1,MAPK8IP2,H6PD,SGCB,STX1A,BCL2L1,H3F3A/H3F3B,ADRA2A,PSME4,NAGLU,SYN1,TNS1,VHL,SUN1,ETV5,PEBP1,SULF1,LOX,IGFBP4,SFTPD,ZP3,CLUAP1,EMX2,LRRC29,HLA-G,EDN1,STUB1,ERBB2,SRC,NLRP3,PLAUR,KIF3B,RRAS2,ACADVL,SPARC,AP3M2,KCND2,BMP4,CTGF,SNTA1,RAN,MST1,POMC,EIF6,MIA,ITGA3,PLS3,LGMN,RARA,HADHA,MCL1,CMKLR1,CDKN1C,NAB1,ATG7,ZC3HC1,PLEC,COMMD9,HBEGF,JUNB,HMGA1,CREB5,THBD,SH3GL1,MAP3K12,EPB42,RTN4,CAPRIN1,SAC3D1,NOTCH1,COL3A1,SORL1,CNN2,MAP7,FYN,LEPR,SIN3B,SLC1A3,ATAT1,MEOX2,H2AFZ,ATP6AP1,EIF4EBP1,MCOLN1,CES1,JUN,RHOD,PDE3B,HGS,ACVR1C,ABHD5,COL12A1,CSK,EGR1,DAAM1,SBF1,BMF,ARID4A,PFN1,FAT1,CD36,CD4,MAP1B,MNS1,CLIP3,LHCGR,IKBKG,CAMK2D,MYOM1,ETS2,AMPH,GSK3B,RET,FZD2,EPB41L1,FERMT3,TTYH1,PTPRE,FST,ACP2,SHARPIN,EGR3,TALDO1,SLC4A7,MAPK8IP3,RAP1GAP,PRKCD,RARRES3,IDO1,CLCN7,--,SLC4A11,NGF,WDR13,PTPRF,CD55,MAN2C1,NFKBIA,THBS1,DKK3,SULF2,HMGCL,MAPKAPK2,ACADM,ADRB2,RHBDD3,ZFP42,EMILIN1,PAK4,AP2M1,COL5A2,EPAS1,ATP2C1,HYAL1,LRRK2,COL1A1,KIF2A,EBF1,APOC1,MT1F,EPHB3,PDE8B,GAP43,NCKAP1L,XK,SYTL2,CACNA1H,COL8A1,SERPINA3,SPI1,ATP2A2,ODC1,TYSND1,IP6K3,LUM,CAV1,NABP2,DLG4,ATF4,EBF2,CASQ2,VPS4B,MRPL24,CERS6,SELE,DPT,MTSS1,CIDEC,MAD2L2,ANO6,HAX1,TMEM127,PYGO2,MN1,IFT122,CTSA,PPP1R15A,TFRC,CD86,ITGA1,PTPRA,APOE,SLC4A2,FGF2,GDF15,CEBPD,CDK4,CTHRC1,MTFP1,CCL2,GADD45A,SORBS1,PLIN2,SOS1,CSNK2B,POMGNT2,RAD21,HEY1,CCR1,TSTA3,S100A1,TJP1,CUL7,DGAT2,TOB1,GFRA2,GPM6B,AGL,GRN,FOS,PLA2G4A,LDLR,NTRK3,FLNC,SERPINH1,TPP1,ARHGDIA,MAN2B1,PIN1,ST3GAL4,ADRA1A,KTN1,PTTG1,ABCA3,MBP,HSPA1A/HSPA1B,PARP2,ABCG1,TYMP,BIN1,MYC,TGFBR2,HSPA4,ADGRF5,RHOB,CXCL14,GCLM,CHTF18,CAST,ATF3,PKP2,GM2A,LAMA2,UNC13B,THRA,PTGDS,ARSA,KLF4,MLST8,OGN,DUSP1,GIPC1,ALDH1A2,HIF1AN,IGFBP3,CAPN2,MDK,ESR1,RBP4,PTGFR,SRPX,TPR,CADPS2,GLRX,CIAPIN1,MSRB3,SHC1,NET1,ENPP2,MCRS1,ATP13A2,AGT,VCAM1,NUSAP1,PARVA,SLC12A2,TUBG1,UPP1,ST3GAL6,EMD,BSCL2,PSME3,ZPR1,SERPINE2,RCAN1,PMP22,TACC2,KIF5B,VAV3,HEPACAM,LPAR5,DNM1L,PNPLA6,PLIN1,ITSN1,HRAS,SH3GLB1,CDKN2C,HOXA9,PCOLCE,SLC4A3,PEG10,ABR,GAA,ZHX2,VEGFD,IRS2,HEY2,EYA2,WNT5B,ARHGEF4,RASL10B,CHN1,CPA3,IER3,TNK2,PLOD1,S1PR3,SERINC2,DOCK1,SRGAP3,CDH2,CCND2,CD68,MAP2K3,LRP8,MAPK7,SFRP1,IFIT2,ITGA7,PHLPP1,ADM,SPTBN1,ADAM17,TCEA1,PSMB10,CHCHD6,TNFSF10,MYH11,DCLK1,VTI1B,VCAN,COL5A1,ID1,TRIB1,MTOR,GBA,CMTM8,STARD13,DAP3,PRKCE,STIM1,COL18A1,NCKIPSD,PLOD3,IL11RA,MBOAT7,CYP11A1,MYCN,CTSK,C5AR1,TYROBP,IMPDH2,HDC,DPAGT1,CYP1B1,POMGNT1,YBX2,F11R,LAMP2,KRT8,WAS,LIMS1,SPRY2,CHFR,LSP1,FCER1G,PEA15,BNIP3L,CBX4,NEDD9,SYN2,PHLDA1,PLA2G15,CXCL12,LIPE,TPM1,SDC4,TAF10,CYP26B1,BRSK1,PRND,IP6K1,LTBR,CCDC86,CLCN3,FBXO45,KLF2,ADRA1B,ACTA1,PDK4,EIF2AK1,CSF3R,MIF,MGRN1,SPP1,DNASE2,LMO4,SGCG,ITPR2,LMNA,ITGAM,ERCC1,CORO1B,PKD1,RGN,TMOD1,MAP2K5,LEP,EPB41L3,ERN1,ABL1,CDH23,SLC7A1,SMPD1,ELOVL3,GPR34,CDKN2B,AEBP1,FLNA,KCNMA1,RPS6KB2,ARHGEF2,NEK7,CUL9,ALPL,CTDNEP1,PRNP,CD59,CXCR4,AP3D1,MTMR14,SCIN,CCDC3,NFKBIZ,CSF1R,ITPA,CYTIP,LPAR1,ELK1,YME1L1,EPB41L2,RCAN2,P2RX7,MMP9,ATP6V1B2	528	
Molecular Transport	transport	transport of molecule	1.27E-12	Increased	3.782	bias	0.230	ACAT2,SLC6A9,KCNJ2,AXIN1,IL6,SLC39A8,CSE1L,TSC2,SMARCB1,SLC2A5,SEC13,NPR3,ATOX1,SLC27A1,PLTP,TRIAP1,FTH1,EPHX1,FHL1,LTBP2,SLC1A5,GNA11,ADIPOQ,DDX3X,LLGL1,LY6E,ABCC9,SLC25A1,IGF2R,MYO5A,GPAM,LYN,SOCS3,RARRES2,AKR1C3,CA4,RABEP1,TRPM8,FCER1A,RGCC,AP1B1,GPC3,AK1,TEK,CPNE1,CXCL8,STXBP1,TJP2,STK39,STX1A,BCL2L1,ADRA2A,SLC7A2,COMMD1,SLC25A10,SYN1,VHL,SLC11A1,UBE2I,KCNK3,RPH3AL,ZP3,BMP2,KCNS3,SNX16,EDN1,ERBB2,CRYM,SRC,SNTB1,SYT11,AP3B2,SNX27,MT1A,BTK,FECH,ING1,CXCL2,MAP4K4,KCND2,ASPSCR1,BMP4,RAN,POMC,SLC15A4,NR4A3,ITGA3,PNKD,LSS,CTNS,SFRP4,HMGA1,SLC25A22,CORO7/CORO7-PAM16,AAAS,EPB42,RTN4,ALAS2,AKR1C4,ANG,SORL1,FYN,ATP6V0B,PPP1R3C,SLC1A3,CASP4,ABCA5,ATP6AP1,GPIHBP1,CES1,JUN,CCL8,CSF2RA,HGS,GJB2,SLC25A13,ABHD5,EGR1,TMED2,ACLY,SLC35B1,RELN,GABRE,VPS9D1,SLC2A8,SLC48A1,PQLC2,PTGS2,TNFRSF4,CD36,CD4,MAP1B,CLIP3,LHCGR,CAMK2D,PTGES2,PLA2G5,GSK3B,RET,STX11,HK1,TTYH1,ACSL3,FST,HSPA9,FBXO22,SLC39A3,MAPK8IP3,SLC2A10,ERP29,PRKCD,CD14,CLCN7,LMAN2L,ARL2,SPIRE1,PPP1R1A,SLC4A11,NGF,IPO9,NFKBIA,THBS1,SMO,SLC25A15,CHCHD4,GOT2,ADRB2,RHBDD3,AP2M1,EPAS1,ATP2C1,P2RX4,PCOLCE2,ANKRD54,ANO2,RUFY1,COL1A1,APOC1,ACAT1,PLP2,NUCB2,CPEB1,XK,SLC47A1,NIPA2,SYTL2,CACNA1H,CTSG,ATP2A2,SLC9A1,SLC8B1,NSF,EGR2,P3H1,CAV1,EBF2,SLCO2B1,VIPAS39,VPS4B,TIMM44,SMG5,ANO6,RHBDD1,PLLP,NPY5R,SLC7A10,HSPA8,TNPO2,MICU1,CTSA,SLC16A5,TFRC,P2RX6,SQSTM1,SLC35B4,ADIPOR2,TOMM40,APOE,SLC4A2,FGF2,CUBN,GDF15,CDK4,CRAT,THOC3,SLC35B2,SLC31A2,G6PC3,IFI27,CCL2,POFUT2,SORBS1,ARFGAP1,PLIN2,RANGAP1,ADORA1,HCAR2,RAB4B,SLC38A7,CCR1,MAPKAP1,TOB1,SLCO2A1,TRIB3,PLA2G4A,HP,NRXN2,LDLR,GPBAR1,ATP1A2,SLC22A18,POLA2,BMPER,TTYH3,BMP6,ABCC3,ABCB6,MT2A,SESN2,SNX8,ATP2B1,ABCA3,MBP,ITGB1BP1,MCUR1,ABCG1,HSPA5,AP2A2,MYC,RHOB,KCNAB1,PDCD6,PRELID3A,NEDD4L,CHMP1A,KCNJ8,ATF3,PEX7,GM2A,VEGFC,THRA,ANO1,PTGDS,SLC3A2,FOSB,KCNG1,ABCA8,GIPC1,RAB26,AGAP3,TMEM165,ESR1,RBP4,RUNX1,SPIRE2,SLC1A4,SCARA5,TPR,STX6,SLC38A1,CADPS2,CCL3,SLC2A3,VPS4A,IRAK1,SLC19A3,SAA1,AGT,GJA4,SLC20A1,SLC22A12,SLC12A2,AP1S2,CANX,DNAJC1,ZPR1,ATP6V1E1,CIDEA,KIF5B,CAT,SMG7,GAPVD1,DNM1L,ADHFE1,NNAT,SLC29A4,CAMK1,APOB,SFXN5,AHCYL1,SGK1,HRAS,SLC4A3,PEX16,NMUR2,CLCNKA,ABCC1,SLC16A2,IRS2,EXOC3,CALCRL,PEX6,SLC24A3,RRBP1,OLFM2,STOML2,SERINC1,SCNN1D,RAE1,SERINC2,AQP9,BSG,GLUL,RAMP3,MAP2K3,ADM,SPTBN1,FOLR2,XPOT,VTI1B,SLC52A2,TRIB1,SLC19A1,PRKCE,ACSL4,STIM1,LIPG,LBP,SLC7A6,FMO3,VPS18,ANGPT1,HDC,STXBP6,KRT8,TF,S100A9,IPO13,SLC25A19,FCER1G,FKBP4,MS4A2,PEA15,NR5A2,GABARAP,SCAMP3,NEDD9,SYN2,ACTR1A,RAB3IP,ADRBK1,ATP5D,CXCL12,XPO5,LIPE,DYNLT1,BRSK1,PRND,SLC7A5,NEO1,KPNA2,CLCN3,EIF2AK1,MGRN1,MIF,NUP155,ITPR2,PKN1,STC1,SRSF3,ARF5,PKD1,SLC22A5,ASIC1,SNX1,XPO6,AOC3,LEP,HPS6,VAPA,PKM,CDH23,SLC7A1,ELOVL3,SMPD1,HIF1A,IRF3,RAMP2,EPHB6,HMOX1,AEBP1,KCNMA1,S100A8,PTGER4,RAB11FIP3,PRNP,CYP27A1,AP3D1,AQP11,TIMM23,SLC7A8,EXOC4,LRP1B,EDNRA,P2RX7,ATP6V1B2	446	
Organismal Development	size	size of body	1.42E-12	Increased	5.003	bias	-2.126	CBX7,SLC6A9,PCLO,CA5B,CACNA1H,IL6,SLC35C1,SPI1,ATP2A2,SLC9A1,EGR2,CCND3,BCAT2,LUM,SMARCB1,MGP,ST6GALNAC2,CAV1,NABP2,ATF4,EBF2,ETS1,HEYL,STK36,SURF1,MAD2L2,HAX1,PYGO2,CTSA,NPR3,APOE,SLC4A2,GNA11,GDF15,CDK4,ADIPOQ,MSRB1,G6PC3,DIABLO,PLIN2,POMGNT2,ALDH5A1,ATN1,HEY1,TSTA3,ZNF521,DGAT2,GFRA2,CDO1,IGF2R,GLG1,FOS,GPAM,PLA2G4A,NRXN2,CBS/CBSL,NTRK3,MAN2B1,BMPER,TP53BP1,AFG3L2,MSRA,PIN1,PTTG1,ITGB1BP1,CA4,KLF6,GPC3,PNRC2,MYC,CTSD,ADGRF5,STC2,CXCL14,MTMR2,CHTF18,H19,ADAMTS1,LAMA2,MAPK8IP2,BAMBI,H6PD,SGCB,THRA,ANO1,GNAZ,STX1A,FOSB,DUSP1,ALDH1A2,HIF1AN,IGFBP3,H1F0,ESR1,SUN1,ETV5,RUNX1,SULF1,IGFBP4,SFTPD,CADPS2,INPPL1,AHNAK,STUB1,AGT,SRC,DHRS3,SLC12A2,NQO1,G6PD,CANX,BSCL2,RCAN1,ING1,BMP4,ITSN1,MAF,CDKN2C,POMC,EIF6,GTF2IRD1,APRT,HOXA9,SGPL1,MFAP2,LGMN,IRS2,HEY2,NAB1,ATG7,NDRG1,SV2B,ZC3HC1,CHN1,CENPB,DKC1,PLEC,HBEGF,MMP2,HMGA1,NLRX1,SH3GL1,DOCK1,GAMT,AAAS,BSG,RAMP3,LRP8,SFRP1,BACE2,COL3A1,SPTBN1,HIST1H1C,FYN,ADAM17,ZFP36,LEPR,MYH11,MEOX2,VTI1B,EIF4EBP1,ID1,TRIB1,MCOLN1,STARD13,SOCS2,SLC19A1,PRKCE,STIM1,PLAT,MBOAT7,MYH1,MYCN,SLC25A13,CTSK,ABHD5,BLMH,TYROBP,COL12A1,POMGNT1,COL5A3,LAMP2,KRT8,SLC2A8,BMF,SPRY2,FCER1G,PEA15,FKBP4,DBNL,BNIP3L,ZFP36L2,CHD7,MAMSTR,ARID4A,CD36,MAP1B,LHCGR,ESAM,IKBKG,ITGA11,IP6K1,CLCN3,ACTA1,APLNR,SPP1,FST,DNASE2,SGCG,ITPR2,LMNA,FZD9,MYOF,ERCC1,PRKCD,SNX1,RGN,CLCN7,RCE1,--,LEP,SFRP2,NFIX,NLGN1,ABL1,SLC7A1,TNFAIP3,TET1,SMPD1,NGF,HMOX1,TMEM119,AEBP1,HINT1,NFKBIA,ANGPTL4,KCNMA1,IFRD1,SULF2,CUL9,ALPL,ADRB2,COL5A2,TPST2,CXCR4,AQP11,SMAD7,CSF1R,EBF1,ITPA,LPAR1,GAP43,P2RX7,MMP9	254	
Carbohydrate Metabolism	metabolism	metabolism of carbohydrate	1.46E-12	 	1.136	bias	-1.493	RPE,VAC14,IL6,SPI1,IDUA,PPP1R3F,IP6K3,GYS1,GNA15,CCND3,GLB1,SMARCB1,ATF4,ALDOC,GALK1,PPP1R15A,CTSB,GAPDH,SLC27A1,ITGA1,B3GAT3,EPHX1,APOE,FGF2,HS2ST1,DPM2,ADIPOQ,HEXA,G6PC3,B4GALT7,CCL2,CS,SORBS1,RENBP,ADORA1,ALDH5A1,TSTA3,DGAT2,AGL,PTDSS2,CBR3,GALM,GPAM,ZFPM2,NR4A2,NTRK3,LYN,FBP1,MAN2B1,NDST2,HAGH,ADRA1A,SOCS3,PIGU,MYC,MTMR2,PFKFB3,CXCL8,GM2A,H6PD,VEGFC,FIG4,ACBD6,IGFBP3,NAGLU,VHL,ANGPTL8,PTGFR,SULF1,BMP2,ATF6,INPPL1,GFPT2,ALDH2,EDN1,ENPP2,ERBB2,AGT,NQO1,ST3GAL6,G6PD,GNAI1,PYGB,XYLT2,PIGB,COL11A1,GSTO2,GAPVD1,PNPLA6,NNAT,GFPT1,CTGF,PLIN1,GMDS,SGSH,HRAS,SH3GLB1,POMC,NEU1,NR4A3,LPIN1,GAA,IRS2,LYVE1,PIK3C2B,HBEGF,MMP2,SERINC1,GRK5,THBD,S1PR3,LARGE1,SERINC2,AQP9,NR1D1,BSG,PIP5K1C,ALDOA,SFRP1,SCAP,PIGO,RALA,LEPR,PPP1R3C,PFKL,MTOR,PDE3B,DCXR,PI4KA,MBOAT7,PLAT,ABHD5,ANGPT1,DPAGT1,PLA2G2A,SLC2A8,GALE,S1PR1,GNPDA1,NAGK,PFKFB1,ADRBK1,CD36,PLA2G15,LHCGR,LIPE,PIGQ,GUSB,PGD,ALDH1A1,PCYT2,IMPA2,IP6K1,GOT1,PGP,GSK3B,GPC1,ADRA1B,PHKG1,HK1,FUCA1,MIF,APLNR,SPP1,GNG2,TALDO1,FOXC1,GPAA1,SORD,RGN,EXTL3,AKR1B1,GMPPB,B3GALT6,LEP,CHPF,PKM,PPP1CB,PPIP5K1,MAN1B1,HIF1A,NGF,KIT,SULF2,ACADM,STK40,PI4KB,PTGER4,ADRB2,ASIP,HYAL1,COQ2,CSF1R,GBE1	194	
Cellular Movement, Skeletal and Muscular System Development and Function	migration	migration of smooth muscle cells	1.51E-12	 	-1.604	 	-3.297	ADRBK1,IL6,SDC4,MYC,CAMK2D,NEO1,TXN,GSK3B,TEK,ELN,CXCL8,CALCRL,SPP1,ATF3,COMP,HBEGF,TFPI2,ITGAM,DUSP1,RTN4,RAMP3,CYR61,mir-21,ADM,IGFBP4,APOE,FHL1,ADAMTS7,LEP,FGF2,BMP2,ADIPOQ,CDK4,TNFSF10,MEOX2,NGF,RAMP2,VCAN,PTPRF,HMOX1,CCL2,THBS1,TIMP1,MAPKAPK2,PTGER4,AGT,PLAT,EGR1,NQO1,PLAUR,CYP1B1,F11R,RCAN1,LDLR,LPAR1,S1PR1,PTGS2,CXCL2,KDR,MMP9	60	
Cellular Movement	invasion	invasion of cells	1.53E-12	 	1.785	 	-1.227	IL6,SPI1,SLC9A1,ODC1,CTSH,CSE1L,KEAP1,CAV1,HIPK2,AHCY,ETS1,TFPI2,HAX1,DVL2,CDH5,FSCN1,CTSB,ALCAM,ITGA1,SQSTM1,mir-21,NME1,GBP1,FGF2,GDF15,ADIPOQ,CCL2,SOS1,DAB2,PIK3R2,ASPH,CCR1,TJP1,GRN,FOS,NR4A2,NTRK3,LYN,TAGLN,WBP2,ARHGDIA,SOX9,BMP6,ID4,PTTG1,HAVCR2,KLF6,HSPA5,CBX5,MYC,TGFBR2,CTSD,RHOB,MAP2K2,TMEM8B,CXCL8,ATF3,ADAMTS1,VEGFC,KLF4,BCL2L1,CDC42BPB,SDCBP,NOL3,ADRA2A,GIPC1,LIMA1,CAPN2,MDK,DNAJB6,ESR1,VHL,S100P,ETV5,TNFAIP8,PEBP1,SULF1,LOX,PLGRKT,BMP2,ETV6,HDGF,SHC1,EDN1,AHNAK,NET1,TIMP1,MCAM,SAA1,RNH1,ENPP2,ERBB2,AGT,SRC,VCAM1,PARVA,SLC12A2,NQO1,GNAI1,PLAUR,SERPINE2,CAPNS1,RRAS2,VAV3,CAT,SPARC,COL11A1,ALKBH3,MAP4K4,BMP4,CTGF,DNAJB4,TGFBR3,HRAS,MST1,MIA,SATB2,ITGA3,LGMN,CCNB1IP1,NPTX2,VEGFD,IRS2,WNT5B,MATK,BIRC7,NDRG1,HBEGF,MMP2,TNK2,MBD2,HMGA1,IER3,JUNB,THBD,ROR1,S1PR3,DOCK1,CDH2,TIMP4,ASGR1,BSG,MAP3K20,SFRP1,MAPK7,CYR61,IFIT2,PDGFD,NOTCH1,ANG,NRP1,ADM,FYN,ADAM17,RALA,WASF3,TNFSF10,FKBP1A,RUVBL1,VCAN,ENAH,ID1,CA3,MTOR,JUN,CST3,RHOD,CMTM8,CD24,PRKCE,ACSL4,SH3GLB2,LDLRAP1,COL18A1,PLOD3,PLAT,SOX7,MYCN,CTSK,PTPRK,CSK,EGR1,FAM43A,ARHGAP4,SLIT2,AXL,RELN,CYP1B1,OTUB1,KRT8,S100A9,PLEKHG6,WAS,SPRY2,CHFR,PTGS2,NEDD9,TFF3,PTPN23,FAT1,UNC5B,CXCL12,SDC4,PARVB,ETS2,OSR1,GSK3B,C1QBP,GPC1,RET,MIF,FST,SPP1,GSDMB,FOXC1,INHBB,ITGAM,RAP1GAP,PRKCD,SCRIB,CD14,RGN,MAP2K5,COL7A1,ADAMTS7,LEP,PA2G4,PKM,ABL1,MYLK,SMPD1,HIF1A,NGF,PDCD4,EPHB6,HMOX1,RAB5A,NFKBIA,ANGPTL4,DKK3,FLNA,KCNMA1,THBS1,CSPG4,S100A8,STK24,MAPKAPK2,PI4KB,ADRB2,PAK4,EPAS1,BHLHE41,CXCR4,SMAD7,PRMT1,FAF1,LPAR1,PAG1,ACAT1,ELK1,KDR,MMP9	262	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of muscle cells	2.04E-12	 	0.619	 	-0.663	BMP4,TGFBR3,ELANE,HRAS,IL6,SLC9A1,ODC1,NR4A3,CYBA,RARA,CAV1,TXN,HEY2,HEYL,CALCRL,CDKN1C,TNFRSF10B,HBEGF,GRK5,JUNB,NPY5R,THBD,TFPI2,NPR3,NCF2,CTSB,PDGFD,PTPRA,ANG,NOTCH1,mir-21,ADM,APOE,FHL1,ADAM17,FGF2,NQO2,GNA11,ADIPOQ,CDK4,CEBPD,TNFSF10,NAA35,H2AFZ,VCAN,TGM2,EFNB2,TRIB1,MTOR,JUN,CCL2,STIM1,HEY1,FCER2,PLAT,MYCN,EGR1,ID3,CYP1B1,POMGNT1,FOS,NR4A2,S1PR1,PIN1,PTGS2,MAMSTR,SOCS3,ADRBK1,CXCL12,FCER1A,SDC4,MYC,TGFBR2,CAMK2D,PLCE1,COMT,GSK3B,ELN,CXCL8,NOX4,MIF,FST,SPP1,PTGDS,AGTRAP,KLF4,OGN,NOL3,DUSP1,ALDH1A2,IGFBP3,CAPN2,DNAJB6,AKR1B1,ESR1,RBP4,IGFBP4,LEP,BMP2,TNFAIP3,SMPD1,HIF1A,AKIP1,CCL3,PTPRF,TNFRSF12A,IRAK1,HMOX1,SHC1,RAB5A,EDN1,THBS1,TIMP1,KIT,HSD11B2,AGT,PRNP,NDUFV1,NQO1,GNAI1,EMD,PLAUR,CXCL16,LPAR1,EDNRA,SPARC,ELK1,MMP9	128	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of phagocytes	2.65E-12	 	-0.353	 	-3.245	CTGF,ELANE,CTSG,HRAS,MST1,SERPINA3,IL6,SPI1,HOXA9,ABCC1,LUM,CAV1,VEGFD,TXN,TNFRSF21,CMKLR1,SELE,NDRG1,PLEC,ANO6,FLOT1,THBD,NINJ1,S1PR3,AQP9,PIP5K1C,MS4A4A,PPP1R15A,CTSB,IL10RA,RTN4,ALCAM,CD86,ITGA1,SFRP1,PLTP,CYR61,ADM,CNN2,APOE,FYN,ADAM17,DAPK2,NQO2,ADIPOQ,G6PC3,VCAN,CES1,GBA,CCL3L1,CCL8,CCL2,CCL3L3,CST3,CSF2RA,STIM1,LBP,ADORA1,HCAR2,GJB2,PLAT,IL11RA,CCR1,CD209,C5AR1,ANGPT1,TYROBP,CD69,DEFB1,PVR,SLIT2,GRN,F11R,PLA2G4A,HP,SWAP70,LDLR,S100A9,WAS,LSP1,LYN,FCER1G,S1PR1,PROCR,MAP3K8,PTGS2,QPCT,SOCS3,RARRES2,PFN1,ADRBK1,CD36,CD4,UNC5B,SPHK2,CXCL12,HARS,TGFBR2,NARS,RSPO3,IKBKG,RHOB,CXCL14,STAB1,C1QBP,CAST,MARCO,CSF3R,PTX3,ELN,CXCL8,MIF,SPP1,VEGFC,CAPG,PTGDS,TPSAB1/TPSB2,APBA3,STC1,ITGAM,DUSP1,PRKCD,CD14,MDK,C2,AOC3,SFTPD,LITAF,LEP,ABL1,TNFAIP3,MYLK,HIF1A,NGF,CCL3,HMOX1,CD55,NFKBIA,EDN1,TIMP1,THBS1,FLNA,MCAM,DUSP10,SAA1,CFB,KIT,S100A8,ERBB2,MAPKAPK2,PRNP,AGT,THBS4,VCAM1,NLRP3,EPAS1,MMP28,CXCR4,PCOLCE2,NQO1,HYAL1,SMAD7,LRRK2,PLAUR,NFKBIZ,CSF1R,BTK,COL1A1,VAV3,EDNRA,C6,KDR,CXCL2,NCKAP1L,P2RX7,MMP9	176	
Neurological Disease	movement disorder	Movement Disorders	3.08E-12	Decreased	-3.700	bias	-0.667	SLC6A9,CA5B,CACNA1H,ZNF239,CCDC88C,SERPINA3,IL6,SLC9A1,ATP2A2,MT1E,IDUA,EGR2,GLB1,CSE1L,GPRC5C,PPRC1,LUM,CAV1,MAP1A,ATF4,EBF2,CASQ2,AHCY,FBL,SELE,STK36,COCH,PPP1R1B,FLOT1,PTPN3,WDR81,HSPA8,CTSA,PDLIM7,CBLN3,CTSB,GAPDH,SLC27A1,SQSTM1,FTH1,EIF3K,ABHD12,RNF10,APOE,NME1,SLC4A2,DDIT3,GBP1,FGF2,SCUBE2,HEXA,TUBB2B,TGM2,DTNA,DUSP5,MAL2,GADD45A,ADORA1,CYP51A1,ALDH5A1,ATN1,SIGMAR1,MLF2,TRIB3,GPM6B,PSMB6,AGL,IGF2R,ID3,CSTB,MYO5A,FOS,GPAM,HP,NR4A2,LDLR,NTRK3,ATP1A2,TPP1,SOX9,AFG3L2,MSRA,PIN1,ID4,ADRA1A,MAOA,MT2A,ATP2B1,CA4,RTN1,MBP,HSPA1A/HSPA1B,MT1M,HSPA5,MYC,CTSD,AK1,STRN4,KCNAB1,TUBA1C,MTMR2,RASGRP2,LAMA2,MAPK8IP2,ARSA,FOSB,KANK1,BCL2L1,NOL3,H3F3A/H3F3B,ADRA2A,DNAJB6,NDUFS3,SYN1,ETV5,RBP4,PEBP1,FAM107A,SLC1A4,SRPX,COPE,ADH1C,EMX2,GTF3A,ALDH2,DHCR7,SUCLA2,STUB1,TIMP1,COQ8A,CRYM,ATP13A2,PSAT1,AP1S2,SLC12A2,TUBG1,SMAD6,PLAUR,CANX,DNAJC1,ATP6V1E1,RCAN1,PMP22,KCTD13,CAPNS1,ANO3,NREP,PNPLA6,JMJD8,CTGF,AHCYL1,SGK1,RAN,CA12,HRAS,PCDH7,CDKN2C,GHITM,GAA,NPTX2,PNKD,TXN,PKIA,POLR2I,APTX,CDKN1C,NAB1,DBP,NDRG1,CHN1,MT1X,TUBB2A,THY1,GRK5,JUNB,IER3,NINJ1,NGRN,MAP3K12,CDH2,SRGAP3,NR1D1,CD68,PDE1B,RTN4,LRP8,IFIT2,ITGA7,SORL1,NDUFA7,SRD5A1,NQO2,SLC1A3,FKBP1A,KAZN,MEOX2,ABCA5,CORO2B,THBS3,VCAN,UCHL1,MCOLN1,CA3,STOM,MTOR,JUN,GBA,PTS,NAPB,MYCN,TWNK,MYOM2,EGR1,HDC,NBEA,SLIT2,RELN,GABRE,F11R,LAMP2,UQCR10,S1PR1,FKBP4,DBNL,PTGS2,SYN2,SERPINI1,PFN1,PFKFB1,MAP1B,DNAJB2,SDC4,DYNLT1,PLEKHG4,FAM173A,CYP26B1,IKBKG,SLC25A6,COMT,BRSK1,PRND,GSK3B,FBXO45,CLCN3,RTN4R,ADRA1B,MT1G,APLNR,SPP1,ICA1,GPS2,SGCG,EGR3,USP36,LMNA,LMCD1,ITGAM,ERCC1,COL6A3,RAP1GAP,C2orf40,RARRES3,RGN,IDO1,MAP2K5,--,SRM,SH3BP4,LEP,NFIX,EPB41L3,HIGD1A,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,SMPD1,SIL1,NGF,HMOX1,RAB5A,AEBP1,HINT1,DKK3,KCNMA1,MT1L,C7,MICALL1,ACADM,ADRB2,PRNP,DAAM2,LRRK2,SGTA,COQ2,PLSCR4,NDUFA13,ITPA,VAMP1,CYC1,ACAT1,GAP43,UQCRC1,XK,ATP6V1B2,MMP9	307	
Cellular Function and Maintenance	engulfment	engulfment of cells	3.38E-12	Increased	3.459	bias	-0.071	ITSN1,TYRO3,ELANE,C1QA,IL6,SPI1,CLIP1,NKAP,ABR,CYBA,TSC2,LUM,CAV1,ATG7,CHN1,FLOT1,HBEGF,HAX1,AP2S1,HSPA8,DOCK1,COLEC12,ASGR1,PIP5K1C,MS4A4A,CNN2,FYN,APOE,RALA,ATP6V1D,CUBN,HYOU1,ADIPOQ,TNFSF10,ATP6AP1,SF3B3,ASB1,TGM2,RHOD,ARFGAP1,ANXA5,TUB,DAB2,PRKCE,NAA60,STIM1,ADORA1,HGS,FCGR3A/FCGR3B,CD209,UCP2,CSK,STON1,AXL,PLA2G4A,HP,SWAP70,PLEKHG6,S100A9,ATP6V1F,WAS,ANXA3,PELI1,LYN,FCER1G,CH25H,PFN1,CD36,CD4,MAP1B,CLIP3,RGCC,CXCL12,GPC3,CD163,BIN1,AP2A2,MYC,PADI4,RHOB,ETS2,PLA2G5,AMPH,NEDD4L,CLCN3,KLF2,GULP1,MARCO,EIF2AK1,PTX3,CSF3R,MIF,CD302,SHARPIN,CAPG,PGAP3,SRSF3,ITGAM,RAP1GAP,PLEKHF1,PRKCD,CD14,FZD5,SLC11A1,SFTPD,LEP,ANTXR1,ABL1,ABCF1,SMPD1,CCL3,LRRC29,GLRX,HMOX1,THBS1,SAA1,MEX3B,ERBB2,NCL,MAPKAPK2,PTGER4,SRC,AP2M1,EPN1,PLAUR,RPS21,ATP6V1E1,BTK,RUFY1,RRAS2,TSPAN1,CAT,EPB41L2,GAPVD1,P2RX7,ATP6V1B2	136	
Cellular Movement	cell movement	cell movement of tumor cell lines	3.83E-12	 	1.909	 	-1.359	CTSG,IL6,CTSH,CSE1L,KEAP1,SMARCB1,ST6GALNAC2,CAV1,HES6,HIPK2,ETS1,SELE,HAX1,DVL2,CDH5,FSCN1,CTSB,ALCAM,ITGA1,SQSTM1,mir-21,NME1,LTBP2,OSGIN1,FGF2,GNA11,GDF15,ADIPOQ,SYNM,GRINA,TGM2,CCL2,IL34,DAB2,ASPH,S100A1,CD69,PVR,GRN,FOS,NR4A2,NTRK3,FLNC,LYN,WBP2,MAP3K8,SOX9,BMP6,SOCS3,RARRES2,USP5,HAVCR2,PTTG1,KLF6,TRPM8,MYC,ADGRF5,RHOB,TMEM8B,CXCL14,TUBA1C,CXCL8,ATF3,VEGFC,KLF4,FOSB,BCL2L1,KANK1,SDCBP,GIPC1,IGFBP3,CAPN2,MDK,DNAJB6,ESR1,S100P,UBE2I,ETV5,PEBP1,TNFAIP8,SULF1,LOX,IGFBP4,PLGRKT,BMP2,CCL3,HNRNPK,HDGF,SHC1,SH3PXD2B,EDN1,NET1,STUB1,TIMP1,MCAM,ENPP2,IGSF8,ERBB2,AGT,SRC,VCAM1,PARVA,SLC12A2,GNAI1,PLAUR,SNX27,CAPNS1,VAV3,CAT,SPARC,COL11A1,CXCL2,NREP,MAP4K4,CTGF,DNAJB4,NUDT16L1,TGFBR3,ELANE,HRAS,MST1,POMC,HOMER3,SATB2,DGCR6L,MTUS1,VEGFD,DNAJA3,AFAP1,LYVE1,MATK,SFRP4,PIK3C2B,ARHGEF4,NDRG1,HBEGF,MMP2,TNK2,HMGA1,THBD,ROR1,NINJ1,S1PR3,DOCK1,CDH2,BSG,RSU1,MAPK7,CYR61,IFIT2,NOTCH1,NRP1,AKAP12,MME,FYN,ADAM17,RALA,LEPR,TNFSF10,RUVBL1,ASNS,VCAN,ENAH,ID1,MTOR,JUN,CCL3L1,CCL8,CMTM8,STARD13,RHOU,CD24,PRKCE,ACSL4,STIM1,COL18A1,PLAT,PLXNA1,PTPRK,CSK,EGR1,DPAGT1,SLIT2,BRMS1,AXL,KRT8,S100A9,WAS,SPRY2,CNN1,S1PR1,PTGS2,NEDD9,RGS1,PHLDA1,VPS28,PTPN23,FAT1,CD36,SPHK2,CXCL12,SDC4,MTCH2,KPNA2,GSK3B,C1QBP,RET,CLCN3,MYO10,IGFBP6,MIF,SPP1,GSDMB,MAPK8IP3,FOXC1,PKN1,LMCD1,RAP1GAP,PRKCD,ASIC1,CCL18,GDI1,LEP,PA2G4,PKM,ABL1,RARRES1,HIF1A,NGF,PDCD4,HMOX1,RAB5A,NFKBIA,CCL13,DKK3,FLNA,THBS1,KIT,S100A8,NCL,MAPKAPK2,PTGER4,ADRB2,NDUFAF3,PRNP,AP2M1,PAK4,BHLHE41,CXCR4,TRIP6,CSF1R,PRMT1,FAF1,COL1A1,LPAR1,ELK1,KDR,MMP9	258	
Cellular Movement, Skeletal and Muscular System Development and Function	migration	migration of muscle cells	6.50E-12	 	-1.604	 	-3.323	ADRBK1,ITGB1BP1,IL6,SDC4,MYC,CAMK2D,NEO1,TXN,GSK3B,TEK,ELN,CXCL8,CALCRL,SPP1,ATF3,COMP,HBEGF,TFPI2,ITGAM,DUSP1,RTN4,RAMP3,CYR61,mir-21,ADM,IGFBP4,APOE,FHL1,ADAMTS7,LEP,FGF2,BMP2,ADIPOQ,CDK4,TNFSF10,MEOX2,NGF,RAMP2,VCAN,PTPRF,HMOX1,CCL2,NET1,THBS1,TIMP1,SMO,MAPKAPK2,PTGER4,AGT,PLAT,THBS4,EGR1,NQO1,PLAUR,CYP1B1,F11R,RCAN1,LDLR,LPAR1,S1PR1,PTGS2,CXCL2,KDR,MMP9	64	
Organismal Development	abnormal morphology	abnormal morphology of thoracic cavity	1.39E-11	 	 	 	 	CTGF,TGFBR3,RRM2B,CACNA1H,CDKN2C,NCSTN,IL6,SLC35C1,ATP2A2,SPI1,POR,IDUA,ITGA3,DMRT2,CCND3,GAA,RARA,LUM,MGP,CAV1,NABP2,HEY2,HADHA,CASQ2,UNG,MCL1,ETS1,PTGIS,CALCRL,CMKLR1,SELE,PLEC,HBEGF,MMP2,IER3,HMGA1,THBD,GPX7,DOCK1,DVL2,IFT122,CDH2,TIMP4,CCND2,CDH5,ATMIN,MAPK7,NOTCH1,NRP1,COL3A1,ADM,AKAP12,SPTBN1,APOE,HIST1H1C,ADAM17,ZFP36,FGF2,CFC1/CFC1B,CDK4,ADIPOQ,FKBP1A,MYH11,TGM2,EFNB2,ID1,JUN,CST3,SLC19A1,LY6E,RASSF5,COL18A1,CYP51A1,HEY1,MYCN,CTSK,MECOM,MESP1,SLCO2A1,TK2,POLD1,IGF2R,ID3,PLA2G4A,LAMP2,ZFPM2,NTRK3,WAS,DBNL,ARHGDIA,DVL3,SGCD,ADRBK1,CD36,ABCA3,CD4,PLA2G15,GPC3,BIN1,CEBPG,MYC,TGFBR2,RSPO3,IKBKG,ADGRF5,PLCE1,OSR1,NEDD4L,RET,BIRC3,KLF2,TEK,ADRA1B,EIF2AK1,ELN,NOX4,DNASE2,SGCG,PKP2,LMNA,MAPK8IP3,DCHS1,NOL3,PKD1,DUSP1,ALDH1A2,RGN,CAPN2,H1F0,MEGF8,TXNRD2,RBP4,RUNX1,LOX,SFTPD,FLRT2,ABL1,SMPD1,HIF1A,RAMP2,ETV6,CIAPIN1,SHC1,HMOX1,EDN1,THBS1,FLNA,SMO,RPS6KB2,MKL2,ERBB2,HMGCL,ALPL,ACADM,PTGER4,VCAM1,PAK4,DHRS3,EPN1,EPAS1,CXCR4,MTMR14,G6PD,HYAL1,SMAD7,EMD,LRRK2,SNX27,BSCL2,KIF3B,RCAN1,ITPA,ACADVL,VAV3,EDNRA,GBE1,RCAN2,CARM1,MMP9	179	
Cellular Function and Maintenance	endocytosis	endocytosis	1.45E-11	Increased	2.358	bias	-0.501	ITSN1,HRAS,SPI1,NKAP,TSC2,CAV1,CHN1,FLOT1,HBEGF,AP2S1,HAX1,HSPA8,PDLIM7,ASGR1,PIP5K1C,MS4A4A,LRP8,SORL1,APOE,ATP6V1D,CUBN,ACKR2,HYOU1,TNFSF10,SF3B3,ATP6AP1,ASB1,RHOD,ARFGAP1,ANXA5,DAB2,NAA60,STIM1,LDLRAP1,ADORA1,HGS,FCGR3A/FCGR3B,FCER2,CD209,VPS18,STON1,AXL,IGF2R,GRN,MYO5A,PLA2G4A,HP,SWAP70,LDLR,TF,PLEKHG6,ATP6V1F,WAS,DENND1A,LYN,CD36,MAP1B,CLIP3,CXCL12,GPC3,CD163,AP2A2,BIN1,TGFBR2,RHOB,AMPH,STAB1,NEDD4L,GULP1,MARCO,EIF2AK1,SHARPIN,HSPA9,RAB34,SRSF3,ITGAM,PLEKHF1,SCRIB,CD14,SFTPD,SCARA5,ANTXR1,ABL1,ABCF1,INPPL1,MYLK,SMPD1,CCL3,LRRC29,HNRNPK,HMOX1,RAB5A,SAA1,MICALL1,ERBB2,NCL,MAPKAPK2,PI4KB,ADRB2,AP2M1,EPN1,LRRK2,PLAUR,CANX,RPS21,RUFY1,ATP6V1E1,SCARA3,TSPAN1,APOC1,GAP43,GAPVD1,EPB41L2,P2RX7,MMP9,ATP6V1B2	116	
Cancer, Organismal Injury and Abnormalities	benign connective or soft tissue neoplasm	benign connective or soft tissue neoplasm	1.92E-11	 	 	 	 	AHCYL1,RPE,MAF,HRAS,COL8A1,PPP4C,POR,NR4A3,CYBA,TSC2,MTHFD2,PKIA,WNT5B,SLC2A5,ALDH1B1,CAPN6,CALCRL,DPT,PLD3,NDRG1,SLC24A3,NDUFS7,MMP2,IFNAR2,AP2S1,CCND2,ALDOA,P2RX6,HSPB7,SFRP1,CYR61,mir-21,FTH1,COL3A1,NRP1,NOL7,COL4A5,UQCRH,PHLDA2,FGF2,FKBP1A,COL15A1,VCAN,IDH1,EIF4EBP1,COL5A1,COL16A1,MTOR,JUN,SOS1,CD24,COL22A1,COL18A1,ECM2,PI4KA,COL12A1,EGR1,DDX24,STXBP6,CYP1B1,FOS,COL5A3,NR4A2,LSP1,LYN,XAF1,NR5A2,PTGS2,ADRA1A,MAOA,SOCS3,MEGF9,PTTG1,LHCGR,MYC,ALDH1A1,SDPR,CXCL14,ERAL1,RET,ADRA1B,PDK4,HNMT,H19,RPL9,KCNG1,ABCA8,COL6A3,PKD1,ADRA2A,DUSP1,CRABP2,AK2,ESR1,COL7A1,POLR3F,SCARA5,ABL1,RBBP8,SLC7A1,RAMP2,COL1A2,SHC1,GNG11,COL6A1,RGS5,KIT,MICALL1,PTGER4,ADRB2,COL5A2,DLGAP4,COL6A2,HYAL1,CLEC16A,CSF1R,COL1A1,COL11A1,KDR,ATP6V1B2	120	
Cellular Assembly and Organization, Tissue Development	fibrogenesis	fibrogenesis	2.00E-11	 	1.235	 	-0.922	MSRB2,BMP4,CTGF,SGK1,HRAS,SERPINA3,IL6,SLC9A1,CLIP1,ITGA3,BOP1,GLB1,MYADM,KANK3,CAV1,MAP1A,TESK1,SELE,MTSS1,CARMIL1,THY1,MMP2,JUNB,HAX1,CORO7/CORO7-PAM16,PTPRA,mir-21,FYN,APOE,FHL1,FGF2,GNA11,WASF3,CDK4,MSRB1,MYH11,COL5A1,MTOR,CCL2,SORBS1,RHOD,STARD13,TUB,DAB2,PRKCE,LBP,TBCD,PIK3R2,GNG5,COL18A1,ADORA1,NCKIPSD,PLAT,SLIT2,RELN,ARHGEF5,MYOC,PLEKHG6,WAS,SERPINH1,SPRY2,S1PR1,FKBP4,PIN1,PFN1,ITGB1BP1,MICALL2,MBP,MAP1B,CLIP3,CXCL12,FCER1A,RGCC,TPM1,SDC4,CDC42EP2,HSPA5,TUBB,COBL,TGFBR2,ADGRF5,RHOB,MYOM1,GPR4,GSK3B,KLF2,ACTA1,ELN,CXCL8,NOX4,MIF,PKP2,GNG2,PTGDS,MLST8,UBXN11,LMCD1,KANK1,CDC42BPB,COL6A3,PRKCD,CD14,ARL2,LEP,TPR,ABL1,INPPL1,MYLK,HIF1A,PHLDB2,PDCD4,RAP1GDS1,EDN1,NET1,ARHGEF2,ASAP3,PTGER4,AGT,SRC,VCAM1,NUSAP1,PAK4,PKP1,EPAS1,RTKN,PLAUR,SH3PXD2A,KCTD13,LPAR1,EDNRA,SPARC,GAP43,NCKAP1L,KDR	134	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of lipid	2.19E-11	 	-0.178	 	-0.827	ACAT2,VAC14,C1QA,IL6,ATP2A2,POR,BCAT2,GLB1,CAV1,DLG4,CERS6,PTGIS,CIDEC,NPY5R,CDH5,ACACA,ITGA1,SLC27A1,PLTP,ADIPOR2,ABHD12,APOE,GNA11,ADIPOQ,CDK4,G6PC3,GRINA,TGM2,CCL2,SORBS1,PLIN2,ADORA1,HCAR2,SIGMAR1,UCP2,DGAT2,SLCO2A1,GFRA2,GPM6B,TK2,FOS,GPAM,PLA2G4A,HP,LDLR,CBS/CBSL,GPBAR1,ARHGDIA,MAP3K8,ABCC3,ABCA3,MBP,PTTG1,RGCC,ABCG1,MYC,TGFBR2,CTSD,ADGRF5,CXCL14,NEDD4L,NSMAF,TEK,CXCL8,ATF3,STK39,H6PD,FIG4,THRA,PTGDS,ECI1,SLC3A2,BCL2L1,ADRA2A,DUSP1,HIF1AN,NAGLU,ESR1,CCDC80,RBP4,RUNX1,ANGPTL8,PTGFR,SFTPD,KCNK3,PTPMT1,ADH1C,INPPL1,DHCR7,EDN1,TIMP1,SAA1,LOC102724428/SIK1,ENPP2,AGT,SRC,DHRS3,VCAM1,SLC12A2,NQO1,GNAI1,LPGAT1,BSCL2,ZPR1,CIDEA,PMP22,DGKQ,LOC102724788/PRODH,VAV3,PNPLA6,APOB,PLIN1,SGK1,HRAS,CDKN2C,POMC,GTF2IRD1,NEU1,SGPL1,LPIN1,RARA,SPTLC2,SLC16A2,IRS2,HADHA,ATG7,STOML2,GRK5,HMGA1,CRABP1,SRGAP3,AQP9,PIP5K1C,ADM,SCAP,LEPR,SRD5A1,PPP1R3C,TNFSF10,IDH1,TRIB1,MTOR,CES1,JUN,GBA,PDE3B,ANXA5,PRKCE,ACSL4,LIPG,LBP,LDLRAP1,COL18A1,AMFR,PI4KA,MBOAT7,PLAT,CYP11A1,SLC25A13,ABHD5,FMO3,EGR1,BRMS1,ACLY,CYP1B1,PLA2G2A,B4GALT2,SLC2A8,S100A9,DHCR24,FCER1G,FKBP4,NR5A2,PTGS2,TAZ,ADRBK1,PFKFB1,CD36,CD4,SPHK2,PLA2G15,LHCGR,CXCL12,LIPE,CYP26B1,CEL,ALDH1A1,COMT,ACP6,PLA2G5,PCYT2,ADRA1B,PDK4,MIF,SPP1,LMNA,PANK1,ERCC1,PRKCD,CD14,RGN,AKR1B1,LEP,ELOVL3,SMPD1,HIF1A,NGF,TNFRSF12A,HMOX1,AADAC,AEBP1,HINT1,ANGPTL4,PCK2,DKK3,KCNMA1,CSPG4,CFB,CLOCK,RPS6KB2,HSD11B2,S100A8,MAPKAPK2,IFRD1,CTDNEP1,PTGER4,PI4KB,ADRB2,PRNP,FAAH,CD59,CYP27A1,THRSP,APOC1,ACAT1,NUCB2,P2RX7,MMP9	238	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	female genital tract serous cancer	female genital tract serous cancer	2.46E-11	 	 	 	 	PRUNE2,SLIT3,CMTM4,TGFBR3,MAF,CDKN2C,ACP5,IL6,RNASE4,ITGA3,KEAP1,LUM,MGP,TSHZ2,PTGIS,SFRP4,DPT,ITM2A,GUCY1A3,MFAP5,RUNDC3B,CPA3,PARP3,HMGA1,PLLP,TFPI2,CRABP1,SPINT2,TRO,LRP8,SFRP1,NOTCH1,COL3A1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,APOE,GSTM5,MYH11,MEOX2,COL15A1,LAMP3,SYNM,UCHL1,DTNA,MTOR,CMTM8,SOCS2,DAB2,CD24,LPP,ECM2,RAD21,MECOM,STON1,MFAP4,SLIT2,ZFPM2,CLDN5,CBS/CBSL,GALE,CNN1,ANXA3,MS4A2,SEMA3C,PTTG1,PARP2,CXCL12,RGCC,CLEC3B,TGFBR2,GPX3,TNIP1,ALDH1A1,DHTKD1,SLC7A5,KPNA2,ACTG2,PDZRN3,FAM65B,TEK,PDK4,CXCL8,AXIN2,SPP1,ERCC2,TPSAB1/TPSB2,PPP2R1A,ABCA8,MATN2,ALDH1A2,BAP1,AOC3,IGFBP4,CDC20,FRZB,FLRT2,PKM,MYLK,IRAK1,EPHB6,RGS5,KCNMA1,CSPG4,MCAM,SAA1,C7,CFB,KIT,ENPP2,ERBB2,RNF144B,CHEK2,EMILIN1,THBS4,LRRK2,PLAUR,F13A1,C2orf88,PMP22,VAV3,LPAR5,EDNRA,PDE8B,KDR	124	
Cellular Movement, Skeletal and Muscular System Development and Function	cell movement	cell movement of vascular smooth muscle cells	2.49E-11	 	-1.533	bias	-3.101	ADM,IGFBP4,ADAMTS7,FHL1,LEP,ADRBK1,FGF2,BMP2,CDK4,TNFSF10,IL6,MEOX2,SDC4,CCL3,RAMP2,PTPRF,HMOX1,TRIB1,CAMK2D,CCL2,TIMP1,THBS1,NEO1,TXN,GSK3B,AGT,ELN,CXCL8,CALCRL,COMP,SPP1,ATF3,EGR1,NQO1,PLAUR,MMP2,SLIT2,TFPI2,CYP1B1,RCAN1,PLA2G4A,S1PR1,RTN4,RAMP3,PTGS2,KDR,mir-21	47	
Cellular Movement	cellular infiltration	cellular infiltration	2.75E-11	 	-0.187	 	-0.913	CTGF,ELANE,CTSG,HRAS,IL6,SPI1,RARA,CAV1,ETS1,TNFRSF21,CMKLR1,SELE,NDRG1,PLEC,MMP2,JUNB,THBD,NINJ1,PPP1R15A,CTSB,GAPDH,ALDOA,CD86,ITGA1,SFRP1,PLTP,CYR61,mir-21,NRP1,ADM,APOE,ADAM17,GBP1,FGF2,NQO2,HYOU1,ADIPOQ,TNFSF10,TGM2,CES1,JUN,GBA,CCL2,CCL3L3,SOCS2,STIM1,LBP,PIK3R2,GJB2,PLAT,IL11RA,CCR1,CD276,C5AR1,UCP2,SLIT2,ST3GAL3,PLA2G4A,LDLR,S100A9,PELI1,ANXA3,FCER1G,PROCR,MAP3K8,PTGS2,SOCS3,TNFRSF4,ADRBK1,CD36,CD4,MBP,ACO2,UNC5B,CXCL12,FCER1A,HARS,HSPA5,TUBB,TGFBR2,RSPO3,IKBKG,PLA2G5,LTBR,PTX3,CXCL8,MIF,SPP1,FST,STC1,EFS,ITGAM,DUSP1,PRKCD,IGFBP3,CD14,IDO1,MDK,CCL18,AKR1B1,ESR1,C2,TNFAIP8,LEP,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,ALDH2,CD55,NFKBIA,EDN1,TIMP1,THBS1,MCAM,DUSP10,SAA1,CFB,S100A8,ERBB2,MAPKAPK2,ADRB2,AGT,VCAM1,NLRP3,PCOLCE2,NQO1,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,CXCL16,ENO1,VAV3,SPARC,C6,KDR,CXCL2,P2RX7,MMP9	142	
Cancer, Organismal Injury and Abnormalities	advanced malignant tumor	advanced malignant tumor	3.60E-11	 	0.076	 	-1.027	KCNJ2,RRM2B,IL6,POR,CTSH,CSE1L,CAV1,SELE,MFAP5,TNFRSF10B,IFNAR2,TFPI2,HAX1,FSCN1,CTSB,CD86,ALCAM,SQSTM1,PTPRA,mir-21,APOE,NME1,FGF2,HCAR1,GDF15,CDK4,CEBPD,CTHRC1,FNTA,COL15A1,TGM2,C1R,DTNA,CCL2,GADD45A,DAB2,TRIM29,HCAR2,CYP51A1,FCGR3A/FCGR3B,SLC12A8,MECOM,OLFML3,ID3,FOS,ZFPM2,LYN,TP53BP1,SEMA3C,ABCC3,QPCT,SOCS3,AKR1C3,PTTG1,RTN1,PARP2,KLF6,RGCC,RNASE1,MYC,TGFBR2,ADGRF5,RHOB,MAP2K2,HDAC11,STAB1,TUBA1C,PDZRN3,TEK,CXCL8,ATF3,ADAMTS1,VEGFC,CAPG,ERCC2,KLF4,BCL2L1,SDCBP,NOL3,ABCA8,ALDH1A2,FAM26F,CAPN2,DNAJB6,ESR1,RUNX1,ERAP2,LOX,IGFBP4,SRPX,BMP2,EMX2,GLRX,GSTT1,EDN1,TIMP1,MCAM,LOC102724428/SIK1,RNH1,ENPP2,ERBB2,SRC,VCAM1,TUBG1,PLAUR,ATIC,BTK,CLGN,VAV3,CAT,LPAR5,ING1,CXCL2,DPYD,BMP4,CTGF,TGFBR3,CMTM4,HRAS,CDKN2C,GYG2,ACP5,HOXA9,PCOLCE,MIA,ITGA3,PLS3,DGCR6L,MTUS1,VEGFD,NDRG1,GSTM3,TUBB2A,THY1,MMP2,PARP3,HMGA1,MBD2,TNK2,THBD,ROR1,CDH2,ISLR,COLEC12,ASGR1,CCND2,TRO,GLUL,MAP2K3,LRP8,MAPK7,SFRP1,CYR61,NOTCH1,NRP1,ADM,MME,AKAP12,HIST2H2AA3/HIST2H2AA4,FYN,ADAM17,MSC,GSTM5,ZFP36,TCEA1,NID2,SRD5A1,HYOU1,FKBP1A,VCAN,ENAH,IDH1,ID1,MTOR,KAT2B,CCL8,CST3,ANXA5,CMTM8,CD24,PRKCE,STIM1,COL18A1,PLAT,MYCN,C5AR1,IMPDH2,MGMT,EPB41L4B,SLIT2,AXL,RELN,BRMS1,POLD1,CYP1B1,KRT8,WAS,CNN1,PTGS2,ZFP36L2,NEDD9,TM4SF1,FZD7,FBN2,CD36,LHCGR,CXCL12,DNAJB2,TUBB,DHTKD1,LTBR,C1QBP,RET,CLCN3,PTX3,CSF3R,MIF,SPP1,FST,LMCD1,GSR,EFS,PPP2R1A,ERCC1,COL6A3,SCRIB,LSM7,CRABP2,EPB41L3,FLRT2,ABL1,GPR34,HIF1A,TNFRSF12A,PDCD4,EPHB6,HMOX1,NFKBIA,ANGPTL4,FLNA,KCNMA1,THBS1,SMO,KIT,RNF144B,HCST,ALPL,PRNP,EPAS1,BHLHE41,CXCR4,SMAD7,PLSCR4,CPA4,CSF1R,NDUFA13,PRMT1,EMP1,FAF1,C2orf88,NEK11,KDR,DSG2,MMP9	264	
Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Emery-Dreifuss muscular dystrophy	Emery-Dreifuss muscular dystrophy	3.71E-11	 	 	 	 	LOX,FHL1,TGFBR3,HIF1A,TAX1BP3,TGFBR2,COL5A1,COL1A2,PLS3,COL6A1,DAB2,TBCD,EMILIN1,COL5A2,COL6A2,TUBB2A,EMD,LMNA,ACLY,CYB561,COL1A1,COLEC12,SDCBP,COL6A3,SERPINH1,CELF2,S1PR1,BNIP3L,SPARC,RSU1,COL3A1	31	
Cellular Movement	invasion	invasion of tumor cell lines	3.78E-11	 	1.895	 	-0.905	IL6,SLC9A1,CSE1L,CTSH,KEAP1,CAV1,HIPK2,ETS1,TFPI2,HAX1,DVL2,FSCN1,CTSB,ALCAM,SQSTM1,mir-21,NME1,GBP1,FGF2,GDF15,ADIPOQ,CCL2,DAB2,PIK3R2,ASPH,CCR1,TJP1,GRN,NR4A2,NTRK3,WBP2,TAGLN,LYN,ARHGDIA,SOX9,BMP6,ID4,HAVCR2,PTTG1,KLF6,CBX5,MYC,TGFBR2,CTSD,MAP2K2,TMEM8B,CXCL8,ATF3,ADAMTS1,VEGFC,KLF4,BCL2L1,CDC42BPB,NOL3,SDCBP,ADRA2A,GIPC1,LIMA1,CAPN2,MDK,DNAJB6,ESR1,VHL,S100P,ETV5,PEBP1,LOX,SULF1,PLGRKT,BMP2,HDGF,EDN1,NET1,TIMP1,SAA1,MCAM,ENPP2,ERBB2,AGT,SRC,PARVA,VCAM1,SLC12A2,GNAI1,PLAUR,SERPINE2,CAPNS1,VAV3,CAT,SPARC,COL11A1,ALKBH3,MAP4K4,BMP4,CTGF,DNAJB4,TGFBR3,MST1,MIA,SATB2,ITGA3,VEGFD,IRS2,WNT5B,MATK,NDRG1,HBEGF,MMP2,TNK2,MBD2,HMGA1,JUNB,ROR1,S1PR3,DOCK1,TIMP4,CDH2,ASGR1,BSG,MAP3K20,SFRP1,IFIT2,CYR61,NRP1,ADM,ADAM17,RALA,TNFSF10,RUVBL1,VCAN,ENAH,ID1,CA3,MTOR,JUN,RHOD,CMTM8,CD24,PRKCE,ACSL4,LDLRAP1,SH3GLB2,COL18A1,PLAT,MYCN,CTSK,PTPRK,CSK,EGR1,FAM43A,ARHGAP4,AXL,CYP1B1,KRT8,S100A9,PLEKHG6,SPRY2,PTGS2,TFF3,FAT1,UNC5B,CXCL12,SDC4,PARVB,ETS2,GSK3B,MIF,SPP1,GSDMB,FOXC1,INHBB,RAP1GAP,PRKCD,LEP,PA2G4,PKM,ABL1,SMPD1,HIF1A,NGF,PDCD4,EPHB6,HMOX1,RAB5A,ANGPTL4,NFKBIA,DKK3,CSPG4,STK24,MAPKAPK2,PI4KB,ADRB2,PAK4,EPAS1,CXCR4,BHLHE41,SMAD7,PRMT1,FAF1,LPAR1,ACAT1,ELK1,MMP9	203	
Skeletal and Muscular System Development and Function, Tissue Development	growth	growth of smooth muscle	4.05E-11	 	-0.071	 	-1.159	SOCS3,BMP4,ADRBK1,FCER1A,CXCL12,ELANE,IL6,SLC9A1,MYC,TGFBR2,NR4A3,CAMK2D,CYBA,COMT,CAV1,TXN,GSK3B,CXCL8,ELN,CALCRL,MIF,NOX4,CDKN1C,SPP1,TNFRSF10B,HBEGF,PTGDS,NPY5R,THBD,AGTRAP,KLF4,TFPI2,OGN,NOL3,NPR3,NCF2,IGFBP3,CAPN2,AKR1B1,PDGFD,ESR1,NOTCH1,ANG,mir-21,ADM,IGFBP4,APOE,FHL1,LEP,FGF2,NQO2,BMP2,GNA11,CEBPD,CDK4,ADIPOQ,TNFSF10,TNFAIP3,NAA35,HIF1A,CCL3,VCAN,PTPRF,IRAK1,TGM2,EFNB2,TRIB1,SHC1,HMOX1,MTOR,RAB5A,JUN,CCL2,EDN1,THBS1,STIM1,PLAT,FCER2,AGT,EGR1,NQO1,GNAI1,PLAUR,ID3,CYP1B1,FOS,CXCL16,NR4A2,LPAR1,S1PR1,SPARC,EDNRA,SOX9,PIN1,PTGS2,ELK1,MMP9	97	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	microtubule dynamics	4.20E-11	Increased	2.129	bias	-1.475	SLIT3,KCNJ2,AXIN1,MAP6,CACNA1H,C1QA,IL6,SLC9A1,CLIP1,GLB1,AJUBA,TSC2,CAV1,MAP1A,DLG4,PLXNB2,AMHR2,TNFRSF21,STK36,MTSS1,CARMIL1,FLOT1,DVL2,IFT122,FSCN1,BTG2,NCF2,ARHGEF6,ATMIN,GAPDH,ACACA,ITGA1,mir-21,APOE,NME1,TTLL3,PLXNA3,EIF4EBP2,FGF2,GDF15,ADIPOQ,CKAP4,CCL2,LLGL1,RAD21,S100A1,CUL7,GFRA2,PVR,GRN,MYO5A,FOS,ARHGEF5,MYOC,SWAP70,LDLR,NTRK3,LYN,AFG3L2,PIN1,BMP6,KTN1,MAOA,MT2A,NCDN,ATP2B1,MICALL2,DPYSL4,MBP,FCER1A,CEP104,MYC,NNMT,ADGRF5,RHOB,MAP2K2,ARHGAP20,CAST,MARCO,CXCL8,ATF3,LAMA2,MAPK8IP2,RIMS4,CAPG,ARSA,TXNRD1,CDC42BPB,MATN2,CAPN2,ESR1,SYN1,VHL,UBE2I,SULF1,LOX,TMEM138,FAM107A,CDC20,BMP2,FLRT1,CLUAP1,INPPL1,ATF6,HNRNPK,PHLDB2,HDGF,SHC1,NET1,MKL2,LOC102724428/SIK1,ERBB2,AGT,THBS4,SRC,PKP1,NUSAP1,PARVA,TUBG1,NQO1,CANX,PLAUR,TUBGCP2,KIF3B,ZPR1,BTK,PMP22,CAPNS1,TACC2,KIF5B,VAV3,SPARC,TBC1D7,DNM1L,CTGF,BMP4,ITSN1,SGK1,RAN,HRAS,POMC,RAPH1,MIA,EVI5L,ITGA3,MTUS1,ABCC1,KIF21A,VEGFD,TESK1,MATK,RND2,ARHGEF4,RIMS3,ATG7,NDRG1,CHN1,RRBP1,PLEC,THY1,CEP89,GRK5,TNK2,ROR1,THBD,NINJ1,S1PR3,DOCK1,MAP3K12,CDH2,SRGAP3,BSG,PIP5K1C,STIP1,GDPD5,RTN4,RSU1,LRP8,CAPRIN1,CYR61,NOTCH1,NRP1,B9D1,ADM,AKAP12,SPTBN1,FYN,RALA,TCTN1,ATP6V1D,BTG3,WASF3,EFHD1,DCLK1,EIF4EBP1,ENAH,UCHL1,EFNB2,DCLK2,KLF9,ID1,MTOR,JUN,RHOD,SRGAP1,RHOU,SNX10,CLMN,TUB,PRKCE,NPTXR,TBCD,NCKIPSD,PLAT,IL11RA,PTK7,PRPH,GSTM1,CEP164,PTPRK,EGR1,DAAM1,ARHGAP4,CCDC8,SLIT2,RELN,AXL,PLEKHG6,WAS,TENM4,ADCY1,S1PR1,FKBP4,DBNL,PTGS2,GABARAP,RUFY3,TM4SF1,MAPRE3,RAB3IP,PFN1,PTPN23,FARP1,MAP1B,UNC5B,MNS1,CLIP3,CXCL12,CDC42EP2,SDC4,DYNLT1,TUBB,PLEKHG4,PARVB,WDR5,CRIP1,BRSK1,COMT,NEO1,MID1IP1,GSK3B,C1QBP,RET,RTN4R,KLF2,MYO10,FERMT3,TTYH1,PTPRE,EGR3,ACAP1,MAPK8IP3,LMCD1,ITGAM,RAP1GAP,PRKCD,SNX1,RARRES3,KATNB1,CDK5RAP2,ARL2,--,GDI1,ICK,RNF165,LEP,NFIX,EPB41L3,NLGN1,ERN1,VAPA,PKM,ABL1,SMPD1,NGF,PTPRF,TNFRSF12A,PRKCSH,EPHB6,RAB5A,NFKBIA,ANGPTL4,THBS1,FLNA,DKK3,KIT,MICALL1,ARHGEF2,STK24,NSMF,NEK7,IFRD1,MAPKAPK2,SULF2,CUL9,MYO16,PI4KB,PRNP,PAK4,ATP2C1,CXCR4,F13A1,LRRK2,TRIP6,CSF1R,PRMT1,KIF2A,LPAR1,EPHB3,EDNRA,GAP43,ELK1,KDR,RTN3,P2RX7	335	
Cancer, Organismal Injury and Abnormalities	breast or colorectal cancer	breast or colorectal cancer	5.57E-11	 	1.578	 	1.511	PCLO,PAQR7,SLC39A8,POR,AJUBA,PPRC1,SMARCB1,WASH3P,ETS1,SRPRA,DDIT4,SLX4,DVL2,CDH5,ALCAM,SLC27A1,TRIAP1,RAB40C,BRE,mir-21,LTBP2,GBP1,KIAA1211L,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,C1R,RABL6,GPC6,MTSS1L,SLC12A8,EMP3,RNF157,PAMR1,THNSL2,GPR183,PDZD2,MTHFD1L,AFF3,KIF7,SWAP70,CBS/CBSL,NDST2,CYP4F11,AKR1C3,HAVCR2,TRPM8,TMEM169,INTS1,CBX5,TSPAN17,CARD8,NDUFA10,TUBA1C,NSMAF,TEK,ADAMTS1,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,PSME4,C17orf97,RAB11FIP5,MRPL15,ZP3,RPH3AL,FLRT1,EMX2,HDGF,THYN1,COL6A1,F8,IGSF8,EPN1,NLRP3,MMP28,TCEA3,PLAUR,FRMD4A,CLEC16A,RRAS2,ACADVL,TXNDC12,SPARC,FECH,AP3M2,TSC22D1,ING1,CXCL2,MED24,MAP4K4,EIF3C,CTGF,SNTA1,HOMER3,RNF38,ZNF395,PRG4,SPAG8,PNKD,LYVE1,MCL1,PIK3C2B,BIRC7,ATG7,SV2B,CENPB,MT1X,PLEC,FAHD2A,HBEGF,CNOT10,PARP3,MALSU1,APEH,FAHD2B,CCDC136,MAP3K12,EEF2KMT,ISLR,RSAD1,AKR1C4,NOTCH1,NRP1,COL3A1,SORL1,CPSF2,ZFP36,LEPR,NQO2,SIN3B,EFHD1,FKBP1A,RUVBL1,H2AFZ,CST3,ZNF608,TUB,EGFL6,HGS,AHNAK2,GJB2,LIMCH1,RPS24,NAP1L4,CD209,CD276,ANKRD9,STAMBPL1,EGR1,COL12A1,TRIM28,DDX24,RELN,NTM,ACLY,COPS3,SBF1,CELF2,PQLC2,PTGS2,FBXW9,ARID4A,CHD7,COBLL1,CLEC3B,LHCGR,ZNF91,H2AFY2,CNDP2,ETS2,COMT,MCTP1,FAM193A,FST,EGR3,LAGE3,IRX6,SLC4A7,PAWR,ATP10A,SLC39A3,SORD,LRRC41,COL6A3,DUS1L,FRYL,TOMM34,SCRIB,LMAN2L,YIF1A,CDK5RAP2,HIGD1A,ZNF174,MAN1B1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,ASAP3,SULF2,ZNF493,TPST2,ATP2C1,C9orf3,TANC2,LRRK2,CCDC85A,PLSCR4,THRSP,EMP1,COL1A1,PLEKHH1,PAG1,PLP2,MT1F,SLIT3,NIPA2,HCAR3,SYTL2,MAP6,CACNA1H,ANKRD20A4 (includes others),SPI1,ATP2A2,MT1E,ODC1,CAAP1,GATAD2A,NUP93,CYBA,EFHB,ARHGAP39,PLEKHO2,WDR47,ALDH3A1,MRPL24,TSHZ2,ALDOC,NUP43,PDIA5,ALDH1B1,DPT,SOGA1,MTSS1,TIMM44,MFAP5,TNFRSF10B,LAMC3,GPX7,HAX1,WDR81,NRBP1,SLC7A10,PYGO2,TNPO2,MN1,TMEM41B,ARHGEF6,PHF23,TFRC,CD86,KCNIP4,SQSTM1,BYSL,ZDHHC4,NOL7,APOE,NME1,SLC4A2,PLXNA3,IGSF1,CUBN,SCUBE2,GDF15,CEBPD,CDK4,HSD17B11,DUSP22,CTDSPL,CRAT,TECR,KLHDC9,GADD45GIP1,DUSP5,PNPO,POFUT2,CCL2,PLIN2,DAB2,ALG8,ADORA1,HCAR2,RAD21,C11orf54,LIG3,SLC38A7,HELZ,GLRX2,NLGN4X,OLFML3,STON1,C1orf122,FAM178B,ARHGEF5,SDF2L1,NTRK3,ARHGDIA,BMPER,TP53BP1,AFG3L2,PIN1,BMP6,ST3GAL4,CPXM1,HAGH,ADRA1A,KTN1,ISM1,NOC3L,ABCA3,RTN1,ACO2,TYMP,GPNMB,MYC,TGFBR2,TPRN,ADGRF5,RHOB,CXCL14,ZNF598,GYPE,METTL5,STAB1,PDCD6,SMPDL3A,PFKFB3,ATF3,RILPL1,VEGFC,DCHS1,FOSB,CDC42BPB,ABCA8,MATN2,GIPC1,SORCS2,ESR1,DPH5,C2,RBP4,PMEPA1,MAST2,ERAP2,SPIRE2,CDC20,FRZB,SRPX,SCARA5,MECR,DENND4B,SLC38A1,NEURL4,GSTT1,ETV6,SLC2A3,HLA-DRB1,TRIM6,AHNAK,TIMP1,MCAM,MEX3B,LOC102724428/SIK1,CIZ1,IARS,SLC20A1,VCAM1,PARVA,RNLS,UPP1,ST3GAL6,CANX,N4BP1,BSCL2,PNCK,NFE2L1,SH3PXD2A,SERPINE2,SLK,XYLT2,CLGN,LOC102724788/PRODH,CAT,ISG20,MIB2,SGK1,TRAP1,CDKN2C,VWA5A,HOXA9,NCOA7,SLC4A3,CLCNKA,ABR,ZHX2,ABCC1,VEGFD,HEY2,RIMS3,GSTM3,FANCG,MMP2,IER3,SCNN1D,UBQLN4,RAE1,DOCK1,SRGAP3,PPIH,DHRS9,PIP5K1C,MS4A4A,C11orf80,MAP3K20,IL10RA,ALDOA,TRO,RPL6,HSPB7,LRP8,BACE2,AIDA,PDGFD,ITGA7,RERGL,PFKL,FAXDC2,TAX1BP3,VCAN,TMEM94,TRIB1,TADA3,MTOR,DHPS,ALDH1A3,SRGAP1,ACSL4,PRKCE,COL18A1,PLOD3,PLAT,DNAH6,CYP11A1,SOX7,GSTM1,RRP12,POLD1,STXBP6,PCDH9,NR2C2AP,POMGNT1,TRMT1,P4HTM,F11R,COL5A3,CLDN5,RBM6,PELI1,ZFP36L2,VPS52,MAPRE3,CYP2C8,FZD7,MVD,C10orf54,PTPN23,VPS28,PLA2G15,COBL,CCNL1,SDAD1,OSR1,TMEM150A,KPNA2,SIAH2,LTBR,CLCN3,MYO10,ACTA1,AGBL5,DDX41,ADRA1B,CSF3R,PTX3,APLNR,SPP1,SGCG,ZNF408,MACROD1,LMNA,MARS,PANK1,TRAPPC9,RRP7A,THSD7B,AKR1B1,COL7A1,DRAP1,AOC3,ADAMTS7,B3GALT6,LEP,HPS6,PRDX5,FLRT2,ANTXR1,BCL2L12,UBASH3B,RGS12,ADSL,FLNA,FUBP3,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,DLGAP4,VWCE,CPED1,SMAD7,CSF1R,ENO1,DYM,OLFML2B,TANGO2,RDH5,UBA1,CARM1,ATP6V1B2,MMP9,SHMT2,KCNJ2,AXIN1,PPP2R3B,MTG1,IL6,POLRMT,PPP1R14B,CCND3,EIF3B,CSE1L,MAP1A,AMHR2,AHCY,HEYL,PTOV1,TMEM100,PDLIM7,CTSB,C15orf39,FTH1,EIF3K,EPHX1,COL4A5,GADD45B,DAPK2,GNA11,ZNF419,GTF3C1,MECOM,KIAA1549L,CD69,CDO1,PVR,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,RARRES2,MICALL2,FCER1A,AP1B1,GPC3,CTSD,OSCP1,CCT5,KMT5A,CXCL8,H19,STK39,UROS,CBX6,ERCC2,AKR1B10,ADRA2A,SLC7A2,BAP1,CCDC80,TNS1,SLC11A1,VHL,SULF1,IGFBP4,DNASE1L3,PLGRKT,BMP2,INPPL1,COL6A6,HLA-G,ALDH2,ESPNL,EDN1,ERBB2,THBS4,SRC,PATL1,RGS20,COL6A2,ITM2C,COL11A1,FCGBP,PRUNE2,KCND2,DDX11,BMP4,TYRO3,PCDH17,GYG2,POMC,ACP5,NR4A3,PLS3,IRX3,RARA,KIF21A,CAPN5,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,NLRX1,RNASEH2A,ROR1,BCAP29,NGRN,FARSA,LARGE1,DPH2,AAAS,C19orf53,PDE1B,RTN4,CCT3,ANG,AKAP12,SQLE,FYN,GSTM5,BTG3,CRTAP,HEATR1,ATAT1,FAM174B,NAA35,ABCA5,THBS3,SF3B3,C20orf96,EIF4EBP1,ENAH,NDUFB9,CES1,JUN,ZNF334,CSF2RA,DCXR,CD24,MYO1D,ECM2,FUK,PLXNA1,CEP164,NOL6,PTPRK,MYOM2,WDR55,ARHGAP4,PAICS,NBEA,SLIT2,BRMS1,TMEM42,AXL,PLA2G2A,DCAF13,ANXA3,MAMSTR,TM4SF1,LRFN4,TFF3,TNFRSF4,PFN1,FARP1,FAT1,CD36,CD4,MAP1B,METAP2,NDUFB10,WDR5,GSPT1,SLC25A6,ALDH1A1,MYOM1,BCL7C,AMPH,GPC1,C1QBP,RET,HLA-F,EPB41L1,C7orf50,MT1G,PTPRE,TRIOBP,PACSIN3,GSDMB,ICA1,HSPA9,PCDHA1,MAPK8IP3,ANKRD33,ZNHIT1,FLCN,KIAA0922,PRSS23,RAP1GAP,PRKCD,RARRES3,CLCN7,CRABP2,SMAP1,SH3RF3,SFRP2,KIAA1191,ATF5,SLC4A11,IPO9,ANGPTL4,HSPE1,SMO,CDCA5,IFRD1,NCL,MAPKAPK2,CHEK2,ADRB2,EMILIN1,BEX2,PAK4,LRRC2,EPAS1,PCOLCE2,VSIG4,SGTA,DHX37,PPP1R16A,IL18RAP,PRMT1,COLEC11,NAT8L,CYC1,APOC1,ACAT1,GBE1,NUCB2,PDE8B,CPZ,GPR160,C6,KDR,TNFRSF19,CLEC10A,HLA-DOA,KLHDC8B,PAPLN,CTSG,COL8A1,SERPINA3,PLEKHM2,SLC9A1,CLIP1,FADS3,ZNF263,IP6K3,EGR2,KEAP1,IQCC,CEP170B,CAV1,ATF4,STK32A,TMEM97,UNG,PIGT,TM6SF1,SELE,PODN,PPP1R1B,ANO6,SMG5,MASP1,NPY5R,BRF2,TFPI2,MAMDC2,SHROOM4,ZNF579,HSPA8,EVPL,NRDE2,CTSA,LRRN3,CBLN3,FSCN1,VARS2,BTG2,MCEE,CCDC178,ITGA1,SAMD4A,FGF2,MMP25,SLC35B2,HS3ST3A1,LAMP3,GRINA,COL16A1,ZMYND19,NOL12,RANGAP1,FAM96B,TRIM29,TBC1D10B,FCGR3A/FCGR3B,G3BP2,NINL,MRPL12,ZNF524,TOB1,PRDM11,SLCO2A1,TRIB3,AGL,HSPA2,GLG1,FOS,HP,NRXN2,NR4A2,FLNC,TAGLN,TMEM106C,TAF1C,SLC22A18,MAP3K8,C19orf12,AARS2,NLE1,ABCC3,CSTF3,QPCT,ABCB6,MT2A,FOXRED1,TRAPPC2L,SESN2,ATP2B1,SLC38A10,PTTG1,MBP,PARP2,KLF6,DPP7,POLR3E,STYXL1,AP2A2,CLPP,GSTM2,GPR4,MAP2K2,HDAC11,FAR2,GCLM,CHTF18,CHMP1A,PDZRN3,KCNJ8,LRBA,IER2,MAST4,DOK2,LAMA2,CAPG,PGAP3,ANO1,OSBPL7,C9orf114,KLF4,ELOVL6,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,SOBP,LIMA1,IGFBP3,DNAJB6,MEGF8,DOCK6,PCMTD2,RUNX1,TPR,ABCF1,CRYL1,CCL3,GLRX,GCDH,REXO2,SHC1,MKL2,ENPP2,LRPPRC,TOX2,LONP1,AGT,PSAT1,C4BPB,SUGP2,SLC22A12,TUBG1,PWWP2B,NQO1,NUP210L,PMP22,PIGB,TACC2,KIF5B,ASTN2,NOP16,SMG7,IVD,ALKBH3,NREP,CADM3,DPYD,C1orf115,APOB,ITSN1,TGFBR3,HRAS,NCSTN,RAPH1,PCOLCE,NEU1,PEX16,NMUR2,GAA,NPTX2,ANK2,IRS2,EYA2,WNT5B,MATK,CACHD1,CALCRL,PEX6,NDRG1,SLC24A3,TUBB2A,TNK2,CRABP1,S1PR3,COLEC12,CDH2,TIMP4,ASGR1,CCND2,CD68,BSG,PTPRB,STIP1,ADAMTS18,GLUL,MAP2K3,MAPK7,SFRP1,CYR61,IFIT2,MYEOV,ADM,MME,HIST1H1C,MSC,ADAM17,PIGO,GRB14,ZNF330,TCEA1,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,TTC1,MYH11,DCLK1,RPP40,IDH1,FANCE,COL5A1,EFNB2,GBA,SLC2A6,HLCS,SNX10,CLMN,PSMD14,STIM1,SH3GLB2,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,PI4KA,MYCN,SEMA3G,STK19,ADRM1,IMPDH2,MGMT,DPAGT1,CYP1B1,YBX2,B4GALT2,KRT8,PLEKHG6,TF,S100A9,CDK20,PPP1R16B,IPO13,CNN1,NOP2,DENND1A,LSP1,MS4A2,DVL3,CBX4,NEDD9,FBN2,RGS1,PHLDA1,ADSSL1,CXCL12,UTP4,TPM1,TUBB,MTCH2,CEL,TNIP1,CRIP1,ASXL2,BRSK1,EIF5,SLC7A5,C14orf180,PUF60,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,TEX2,ST6GALNAC3,PKN1,EFS,PPP2R1A,ITGAM,ERCC1,SMOX,SNX1,EXTL3,PLEKHH3,EPB41L3,PKM,ABL1,RBBP8,CDH23,SLC7A1,MRPL2,TET1,TNFAIP3,SMPD1,MYLK,GPR34,ITGA10,SIL1,HIF1A,FBXO3,ACOT7,FAM110B,PDCD4,COL1A2,EPHB6,SOX17,NKD2,NFX1,HMOX1,AEBP1,CCL13,CSPG4,KCNMA1,POLN,CLOCK,KIT,ARHGEF2,NEK7,HCST,CUL9,ALPL,HMGCS1,PI4KB,PTGER4,PRNP,NDUFAF3,TAF6,MIPEP,CXCR4,QSOX1,TRIP6,ZBTB7C,RAPGEF5,COQ2,ZDHHC7,CCDC3,CPA4,ARHGAP28,CYTIP,EXOC4,DIP2C,LPAR1,JCHAIN,DSG2,RTN3	1172	
Cell Death and Survival	survival	cell survival	5.69E-11	Increased	3.967	bias	-1.255	WBSCR22,ASS1,RRM2B,IL6,SLC9A1,ODC1,POR,PPP1R3F,IP6K3,CSE1L,KEAP1,CYBA,KIF1A,MCOLN3,SMARCB1,TSC2,CAV1,ATF4,HIPK2,UNG,SELE,COMP,MFAP5,PPP1R1B,SLX4,TNFRSF10B,MAD2L2,NPY5R,AEN,CDH5,BTG2,NCF2,PSMA4,CTSB,ALCAM,CD86,ACACA,SQSTM1,BRE,PTPRA,mir-21,FTH1,APOE,NME1,GADD45B,DDIT3,FGF2,SEMA6A,GDF15,CEBPD,CDK4,ADIPOQ,DUSP22,CTDSPL,DDX3X,SYNM,DIABLO,TGM2,DUSP5,GADD45A,CCL2,SWI5,DAB2,PIK3R2,ADORA1,TRIM29,RAD21,FCGR3A/FCGR3B,LIG3,CCR1,SIGMAR1,UCP2,MECOM,SPRY1,GFRA2,IGF2R,FOS,PLA2G4A,NR4A2,NTRK3,LYN,SOX9,MAP3K8,TP53BP1,PIN1,ABCC3,BMP6,ID4,LIG1,ABCB6,SOCS3,ITGB1BP1,MBP,HSPA1A/HSPA1B,PARP2,KLF6,FCER1A,TRPM8,TYMP,NARFL,DRG2,HSPA5,GPC3,MYC,TGFBR2,HSPA4,GIMAP5,NUPR1,CXCL8,NOX4,PSMB5,ATF3,ADAMTS1,BAMBI,VEGFC,AURKAIP1,H6PD,PPP1R11,ERCC2,KLF4,FAAP20,BCL2L1,SMUG1,DUSP1,IGFBP3,CAPN2,DNAJB6,MDK,ESR1,VHL,SLC11A1,DPH5,S100P,UBE2I,ETV5,TNFAIP8,RUNX1,SULF1,CARS,SFTPD,DNASE1L3,BMP2,ATF6,CCL3,KIFC2,GLRX,ETV6,IRAK1,HDGF,CIAPIN1,HLA-G,SHC1,EDN1,TIMP1,MCAM,ERBB2,ATP13A2,NDUFAF4,SRC,VCAM1,PARVA,USMG5,SMAD6,PLAUR,PSME3,BTK,RCAN1,CAT,SPARC,RPS6KA4,ING1,CXCL2,ALKBH3,DNM1L,PNPLA6,EIF3C,DPYD,CTGF,APOB,BMP4,SGK1,TYRO3,ELANE,HRAS,NCSTN,NR4A3,SGPL1,NOSIP,RARA,ABCC1,IRS2,TXN,MCL1,BIRC7,CDKN1C,ATG7,NDRG1,GUCY1A3,FANCG,HBEGF,RPA1,IER3,HMGA1,TNK2,THBD,ROR1,LDOC1,S1PR3,MAP3K12,DOCK1,DPH2,CDH2,VKORC1,MAPK7,SFRP1,CYR61,NOTCH1,ANG,TMEM158,NRP1,PHLPP1,FYN,SCAP,ADAM17,EMILIN2,ZFP36,LEPR,CHCHD6,HYOU1,SLC1A3,TNFSF10,KAZN,MYH11,ASNS,VCAN,IDH1,UCHL1,EFNB2,MCOLN1,MTOR,LYZ,BANF1,JUN,CST3,CSF2RA,ANXA5,SOCS2,SLC19A1,PRKCE,CD24,COL18A1,PTPRT,PLAT,IL11RA,PRPH,MYCN,GSTM1,PTPRK,ANGPT1,TYROBP,EGR1,MGMT,TRIM28,ACLY,AXL,DUSP14,LMO3,S100A9,CDK20,PPP1R16B,SBF1,LIMS1,CHFR,FCER1G,PEA15,S1PR1,GPR180,PTGS2,NEDD9,PRPF19,TNFRSF4,SERPINI1,ADRBK1,PTPN23,FAT1,CD4,UNC5B,CXCL12,ZNF91,TUBB,METAP2,CEL,IKBKG,CAMK2D,PLCE1,ETS2,PRND,IP6K1,GSK3B,GPC1,RET,BCKDK,FZD2,KLF2,PDK4,CSF3R,MIF,PTPRE,SPP1,EGR3,USP36,LMNA,AGTRAP,DPP9,GSR,STC1,PPP2R1A,ITGAM,ERCC1,PRKCD,RARRES3,CCL18,MAP2K5,LEP,SFRP2,ATF5,ERN1,ANTXR1,PKM,ABL1,PPP1CB,SLC7A1,TNFAIP3,SMPD1,HIF1A,NGF,PTPRF,PDCD4,HMOX1,RAB5A,HINT1,CD55,NFKBIA,THBS1,FLNA,DUSP10,SMO,RPS6KB2,POLN,CLOCK,KIT,PSMA3,S100A8,NEK7,MAPKAPK2,CUL9,CHEK2,PRNP,BEX2,CD59,CXCR4,RNF126,SMAD7,LRRK2,CSF1R,NDUFA13,THRSP,TRIM69,PRMT1,EMP1,COL1A1,ENO1,EBF1,PBX3,EPHB3,NDNF,ELK1,KDR,P2RX7,MMP9,SHMT2	381	
Dermatological Diseases and Conditions	psoriasis	chronic psoriasis	6.67E-11	 	 	 	 	GARS,TAF10,MTX1,ATP2A2,METAP2,POR,PGD,GNA15,CRIP1,ALDH3A2,EIF5,CCT5,KPNA2,GOT1,C1QBP,IER2,PSME2,THBD,EIF2S2,HSPA8,FSCN1,CTSB,ATOX1,MAP2K3,CRABP2,PCBD1,UBE2I,SRM,SQLE,APOE,ZFP36,PSMB10,PCMT1,PKM,CEBPD,CASP4,HIF1A,ME1,H2AFZ,IRAK1,ID1,HMOX1,CCL2,HSPE1,CD24,GOT2,GJB2,PKP1,TUBG1,UPP1,CSTB,LDLR,S100A9,CNN1,TAGLN	55	
Organismal Development	morphology	morphology of body cavity	7.29E-11	 	 	 	 	SYTL2,RRM2B,CACNA1H,IL6,SLC35C1,ATP2A2,SPI1,TYSND1,POR,IDUA,CCND3,BCAT2,LUM,MTHFD2,MGP,CAV1,ATF4,NABP2,AMHR2,UNG,CASQ2,ETS1,PTGIS,RBM38,HEYL,SELE,MTSS1,MAD2L2,GPX7,PYGO2,DVL2,IFT122,CTSA,CDH5,PPP1R15A,ATMIN,CD86,ITGA1,APOE,SLC4A2,FGF2,CFC1/CFC1B,HS2ST1,GDF15,CDK4,ADIPOQ,CTHRC1,HEXA,TGM2,GADD45GIP1,GADD45A,LY6E,DAB2,GNG5,CYP51A1,HEY1,CCR1,TSTA3,MECOM,SPRY1,MESP1,SLCO2A1,AGL,TK2,IGF2R,ID3,GRN,FOS,PLA2G4A,HP,ZFPM2,LDLR,CBS/CBSL,NTRK3,GPBAR1,LYN,ARHGDIA,SOX9,MAP3K8,MAN2B1,BMPER,SGCD,LIG1,SOCS3,PTTG1,ABCA3,ZFPM1,GPC3,BIN1,CEBPG,MYC,TGFBR2,CTSD,ADGRF5,GPR4,NUPR1,NEDD4L,BIRC3,TEK,MARCO,ELN,NOX4,ATF3,PKP2,ADAMTS1,DOK2,MAPK8IP2,THRA,DCHS1,KLF4,BCL2L1,NOL3,DUSP1,ALDH1A2,IGFBP3,NAGLU,CAPN2,H1F0,MEGF8,ESR1,TXNRD2,TNS1,VHL,RBP4,SUN1,RUNX1,IGFBP4,LOX,SFTPD,SRPX,ZP3,BMP2,CADPS2,EMX2,ETV6,CIAPIN1,SHC1,SLC19A3,DHCR7,EDN1,MKL2,ERBB2,AGT,SLC20A1,SRC,VCAM1,PARVA,DHRS3,EPN1,SLC12A2,NQO1,G6PD,EMD,SNX27,BSCL2,KIF3B,NFE2L1,BTK,RCAN1,XYLT2,ACADVL,VAV3,SPARC,ING1,PLIN1,CTGF,APOB,BMP4,TGFBR3,TYRO3,CDKN2C,MST1,NCSTN,APRT,ITGA3,DMRT2,LGMN,GAA,RARA,IRS2,HEY2,HADHA,MCL1,CALCRL,CMKLR1,ZC3HC1,CENPB,FANCG,PLEC,HBEGF,MMP2,JUNB,IER3,HMGA1,THBD,S1PR3,DOCK1,CDH2,TIMP4,CCND2,BSG,MAP2K3,MAPK7,NOTCH1,NRP1,COL3A1,B9D1,ADM,AKAP12,SPTBN1,HIST1H1C,FYN,ADAM17,ZFP36,SRD5A1,LEPR,FKBP1A,ABCA5,MYH11,VTI1B,EFNB2,TRIB1,MCOLN1,ID1,CES1,JUN,GBA,CST3,PDE3B,SLC19A1,ACSL4,PRKCE,RASSF5,COL18A1,CYP11A1,MYCN,SOX7,CTSK,EGR1,MGMT,AXL,POLD1,COPS3,YBX2,LAMP2,KRT8,WAS,LIMS1,CNN1,BMF,SPRY2,FCER1G,FKBP4,NR5A2,DBNL,BNIP3L,DVL3,PTGS2,ZFP36L2,ARID4A,RGS1,TFF3,ADRBK1,FAT1,CD36,CD4,PLA2G15,LHCGR,SDC4,RSPO3,IKBKG,PLCE1,ETS2,COMT,OSR1,GSK3B,LTBR,RET,CLCN3,KLF2,ADRA1B,EIF2AK1,PTX3,MIF,SPP1,DNASE2,SGCG,LMNA,PAWR,FZD9,MAPK8IP3,ERCC1,PKD1,PRKCD,SCRIB,RGN,AKR1B1,TMOD1,LEP,NFIX,FLRT2,ANTXR1,ABL1,SMPD1,HIF1A,RAMP2,CDKN2B,HMOX1,AEBP1,MAN2C1,CD55,NFKBIA,ANGPTL4,THBS1,FLNA,SMO,CFB,RPS6KB2,HSD11B2,HCST,HMGCL,ALPL,ACADM,PTGER4,PAK4,EPAS1,CXCR4,AQP11,MTMR14,HYAL1,SMAD7,LRRK2,NFKBIZ,CSF1R,COL1A1,ITPA,EPHB3,EDNRA,GBE1,CPEB1,RCAN2,CARM1,MMP9	343	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of smooth muscle cells	8.01E-11	 	0.018	 	-1.099	SOCS3,BMP4,ADRBK1,ELANE,FCER1A,CXCL12,IL6,SLC9A1,MYC,TGFBR2,NR4A3,CAMK2D,CYBA,COMT,CAV1,TXN,GSK3B,ELN,CXCL8,NOX4,CALCRL,MIF,CDKN1C,SPP1,TNFRSF10B,HBEGF,PTGDS,NPY5R,THBD,TFPI2,AGTRAP,KLF4,OGN,NOL3,NPR3,NCF2,IGFBP3,CAPN2,PDGFD,AKR1B1,ESR1,NOTCH1,ANG,mir-21,ADM,APOE,IGFBP4,FHL1,LEP,FGF2,BMP2,NQO2,GNA11,CEBPD,CDK4,ADIPOQ,TNFSF10,TNFAIP3,NAA35,HIF1A,CCL3,PTPRF,VCAN,IRAK1,TGM2,EFNB2,HMOX1,SHC1,TRIB1,RAB5A,MTOR,JUN,EDN1,CCL2,THBS1,STIM1,PLAT,AGT,FCER2,EGR1,NQO1,GNAI1,PLAUR,ID3,CYP1B1,FOS,CXCL16,NR4A2,LPAR1,S1PR1,EDNRA,SPARC,PTGS2,PIN1,ELK1,MMP9	96	
Cellular Movement	migration	migration of tumor cell lines	8.91E-11	Increased	2.095	 	-0.934	IL6,CSE1L,CTSH,KEAP1,SMARCB1,CAV1,HES6,ETS1,HAX1,DVL2,CDH5,FSCN1,CTSB,ALCAM,mir-21,NME1,LTBP2,OSGIN1,FGF2,GDF15,GNA11,ADIPOQ,SYNM,GRINA,TGM2,CCL2,DAB2,ASPH,PVR,GRN,NR4A2,NTRK3,FLNC,WBP2,LYN,MAP3K8,SOX9,BMP6,SOCS3,USP5,HAVCR2,PTTG1,KLF6,TRPM8,MYC,ADGRF5,RHOB,TMEM8B,CXCL8,ATF3,VEGFC,KLF4,BCL2L1,KANK1,SDCBP,GIPC1,IGFBP3,CAPN2,MDK,DNAJB6,ESR1,S100P,ETV5,UBE2I,TNFAIP8,LOX,IGFBP4,PLGRKT,BMP2,CCL3,HNRNPK,HDGF,SHC1,SH3PXD2B,EDN1,NET1,TIMP1,STUB1,MCAM,ENPP2,IGSF8,ERBB2,AGT,SRC,PARVA,VCAM1,SLC12A2,GNAI1,PLAUR,CAPNS1,VAV3,CAT,SPARC,COL11A1,CXCL2,NREP,MAP4K4,CTGF,NUDT16L1,TGFBR3,ELANE,MST1,HRAS,POMC,SATB2,DGCR6L,MTUS1,DNAJA3,VEGFD,AFAP1,LYVE1,MATK,SFRP4,PIK3C2B,ARHGEF4,NDRG1,HBEGF,MMP2,TNK2,ROR1,NINJ1,S1PR3,DOCK1,CDH2,BSG,RSU1,CYR61,IFIT2,NOTCH1,NRP1,AKAP12,MME,FYN,ADAM17,RALA,LEPR,TNFSF10,RUVBL1,ASNS,VCAN,ENAH,ID1,MTOR,JUN,CMTM8,RHOU,CD24,ACSL4,STIM1,COL18A1,PLAT,PLXNA1,PTPRK,CSK,EGR1,DPAGT1,SLIT2,BRMS1,AXL,KRT8,S100A9,WAS,SPRY2,PTGS2,NEDD9,RGS1,PHLDA1,VPS28,FAT1,CD36,SPHK2,CXCL12,SDC4,KPNA2,GSK3B,C1QBP,MYO10,IGFBP6,MIF,SPP1,MAPK8IP3,FOXC1,PKN1,LMCD1,RAP1GAP,PRKCD,ASIC1,LEP,PKM,RARRES1,HIF1A,NGF,PDCD4,HMOX1,NFKBIA,FLNA,THBS1,KIT,S100A8,NCL,MAPKAPK2,PTGER4,ADRB2,NDUFAF3,PRNP,AP2M1,BHLHE41,CXCR4,TRIP6,CSF1R,PRMT1,COL1A1,FAF1,LPAR1,ELK1,KDR,MMP9	217	
Hereditary Disorder, Organismal Injury and Abnormalities	autosomal recessive disease	autosomal recessive disease	1.18E-10	 	 	 	 	CSTA,CTSG,CCDC88C,C1QC,C1QA,IL6,SLC9A1,POR,EMG1,EGR2,CCND3,CYBA,KIF1A,P3H1,CAV1,EARS2,UNG,CASQ2,AHCY,PIGT,SLX4,CIDEC,GFM1,MASP1,LAMC3,HAX1,WDR81,CARD9,PPOX,VARS2,NCF2,PSMA4,AARS,SQSTM1,B3GAT3,PCBD1,mir-21,ABHD12,LTBP2,SFXN4,DPM2,TECR,G6PC3,B4GALT7,CCL2,POMGNT2,GPC6,CYP51A1,FCGR3A/FCGR3B,SIGMAR1,RGS16,SLCO2A1,TK2,ST3GAL3,KIF7,MYOC,LDLR,CBS/CBSL,ATP6V0A2,TPP1,ARHGDIA,C19orf12,AARS2,BMPER,AFG3L2,SGCD,POC1A,RFXANK,GMPPA,ACO2,HSPA5,BIN1,CLPP,CEP104,MYC,TPRN,EXOSC3,CCT5,MTMR2,CAST,CHMP1A,RASGRP2,CXCL8,NBAS,LRBA,TJP2,PSMB5,PEX7,FIG4,PGAP3,SGCB,ARSA,HARS2,ERCC2,DCHS1,FCN3,BCL2L1,SOBP,TMEM165,HOGA1,VPS37A,MEGF8,TMEM138,SFTPD,KIZ,NHP2,INPPL1,POLR1C,MSRB3,SLC19A3,SUCLA2,COL6A1,AHNAK,STUB1,FARS2,COQ8A,LONP1,ATP13A2,ELMOD3,AGT,PSAT1,COL6A2,PGAP2,CANX,RBCK1,XYLT2,PMP22,POLR3B,HEPACAM,TBC1D7,ATPAF2,CYB5A,EFEMP2,PNPLA6,COQ9,NNAT,JMJD8,GFPT1,DPYD,APOB,ELANE,CA12,C1QB,GSS,APRT,LPIN1,PEX16,GAA,SARS2,HADHA,ADCK4,PEX6,NDRG1,GUCY1A3,PLEC,MMP2,RNASEH2A,IRX5,CTPS1,LARGE1,CCND2,GAMT,PSMB2,ADAMTS18,IL10RA,RNASEH2C,EOGT,B9D1,COL3A1,ADAM17,PIGO,TCTN1,SERAC1,CRTAP,ASNS,GPIHBP1,SLC52A2,UCHL1,TARS2,BANF1,GBA,ALDH1A3,PTS,SNX10,STIM1,LDLRAP1,GJB2,PLOD3,IL11RA,SLC25A13,CEP164,TWNK,IMPDH2,DPAGT1,RELN,CYP1B1,POMGNT1,TF,RHBDD2,CYP4F22,GTPBP3,SBF1,SLC25A19,GALE,ADCY1,MS4A2,TNFRSF4,TBX15,HARS,DNAJB2,TSEN54,PLA2G5,LPIN2,HK1,CSF3R,FUCA1,TMIE,HNMT,WDR34,TRIOBP,PARN,SGCG,LMNA,DGUOK,SLC2A10,TRAPPC9,ERCC1,COL6A3,PKD1,PRKCD,ADAMTSL2,CLCN7,KATNB1,CDK5RAP2,PYCR1,COL7A1,GMPPB,ICK,B3GALT6,HPS6,SLC4A11,ANTXR1,RBBP8,CDH23,MAN1B1,NGF,COL1A2,ADSL,HMOX1,HINT1,FLNA,SLC25A15,IFRD1,HMGCL,ALPL,ADRB2,CD59,CYB5R1,F13A1,COQ2,COLEC11,OPLAH,EXOC4,NAT8L,CYC1,RDH5,MPV17,MMP9	268	
Cellular Movement	homing	homing of cells	1.37E-10	 	-0.680	bias	-4.616	CTGF,BMP4,ELANE,CTSG,HRAS,MST1,SERPINA3,IL6,HOMER3,SPI1,HOXA9,ABCC1,TSC2,CAV1,VEGFD,TXN,CMKLR1,SELE,PLEC,HBEGF,ANO6,FLOT1,MMP2,THBD,NINJ1,S1PR3,AQP9,PIP5K1C,YARS,RTN4,ITGA1,CYR61,PDGFD,PTPRA,NRP1,AKAP12,APOE,FYN,ADAM17,RALA,DAPK2,FGF2,NQO2,GNA11,ACKR2,G6PC3,EFNB2,TRIB1,MTOR,JUN,CCL3L1,CCL8,CCL2,CCL3L3,CST3,RHOD,CSF2RA,RHOU,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CSK,CD69,ANOS1,DEFB1,SLIT2,BRMS1,AXL,IGF2R,GRN,HP,SWAP70,LDLR,CBS/CBSL,S100A9,NTRK3,WAS,SERPINH1,LSP1,LYN,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,SOCS3,TFF3,ADGRA2,RARRES2,PFN1,ADRBK1,CD36,CD4,SPHK2,CXCL12,HARS,TYMP,MYC,RHOB,OSR1,CXCL14,C1QBP,LTBR,CLCN3,TEK,MARCO,CSF3R,ELN,CXCL8,MIF,SPP1,APLNR,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,ARHGEF16,PRKCD,SCRIB,IGFBP3,CAPN2,MDK,CCL18,RUNX1,AOC3,LOX,SFTPD,LITAF,LEP,BMP2,ABL1,MYLK,NGF,CCL3,GLRX,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,SEMA3B,MAPKAPK2,PRNP,AGT,THBS4,SRC,VCAM1,MMP28,CXCR4,NQO1,LRRK2,PLAUR,CSF1R,TNFRSF14,CXCL16,LPAR1,VAV3,EDNRA,KDR,CXCL2,NCKAP1L,MMP9	174	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral tumor	oral tumor	1.40E-10	 	-1.342	 	-1.342	CSTA,BMP4,CTGF,PCDH7,HRAS,IL6,ATP2A2,CTSH,RAB38,TSC2,NPTX2,MGP,PLXNB2,MCL1,CTNS,RBM38,DPT,MTSS1,MFAP5,TUBB2A,LAMC3,THBD,GPX7,HAX1,PLAG1,EVPL,BSG,LRP8,PDGFD,IFIT2,NOTCH1,MAP7,EMILIN2,LEPR,CTHRC1,TNFSF10,COL15A1,TGM2,SPON1,CCL8,EGFL6,GPC6,ATN1,G3BP2,GSTM1,SPRY1,TYROBP,DAAM1,DPAGT1,GALM,F11R,S100A9,CNN1,TAGLN,CILP,PTGS2,CHD7,TM4SF1,SERPINI1,SLC38A10,CXCL12,TPM1,GPC3,MYC,CYP26B1,ITGA11,CXCL14,TUBA1C,CXCL8,IGFBP6,TEX264,BCL2L1,H3F3A/H3F3B,PKD1,DUSP1,MATN2,IGFBP3,C17orf97,S100P,SULF1,PKM,PPP1CB,ITGA10,GSTT1,ADSL,TIMP1,SRGN,SMO,S100A8,ERBB2,CHEK2,THBS4,TUBG1,ATIC,COL1A1,EBF1,LPAR1,ING1,COL11A1,CXCL2,KDR,DSG2	102	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	hereditary myopathy	hereditary myopathy	1.50E-10	 	-1.649	bias	-0.262	NDUFA9,KCNJ2,TGFBR3,RRM2B,SNTA1,GARS,C1QB,GSS,PLS3,EGR2,GYS1,CCND3,ANK2,HEY2,MYL3,NDRG1,NDUFS7,TUBB2A,SURF1,PLEC,LARGE1,COLEC12,HLA-DRB4,YARS,PSMA4,RSU1,AARS,SQSTM1,ITGA7,mir-21,COL3A1,FHL1,CHCHD10,FKBP1A,TAX1BP3,COL5A1,DTNA,MTOR,DAB2,STIM1,TBCD,ABCC9,POMGNT2,SIGMAR1,COL12A1,DPAGT1,LRSAM1,ACLY,TK2,POMGNT1,LAMP2,SBF1,FLNC,SERPINH1,S1PR1,CELF2,BNIP3L,AARS2,TAZ,SGCD,ADRA1A,FOXRED1,CA4,TPM1,TYMP,DNAJB2,HSPA5,BIN1,TGFBR2,MYOM1,DHTKD1,CXCL14,NDUFA10,MTMR2,CAST,ADRA1B,PDK4,HK1,KCNJ8,PSMB5,NUP155,PKP2,SGCG,LAMA2,LMNA,FIG4,SGCB,NDUFAF2,MARS,PUS1,CYB561,SDCBP,TLN2,COL6A3,NAGLU,DNAJB6,NDUFS3,TMOD1,TXNRD2,GMPPB,LOX,LITAF,HIF1A,NGF,COL1A2,HINT1,SUCLA2,HLA-DRB1,COL6A1,AHNAK,LRPPRC,ISCU,ADRB2,PRNP,EMILIN1,COL5A2,COL6A2,MTMR14,EMD,CANX,BSCL2,RBCK1,COL1A1,PMP22,NDUFS8,ACADVL,SPARC,UBA1,DSG2,MPV17,COX15	131	
Cell Death and Survival	apoptosis	apoptosis of endothelial cells	1.54E-10	 	0.270	 	0.174	ISM1,ITSN1,CD36,ASS1,CXCL12,HRAS,SERPINA3,TYMP,HSPA5,MYC,NR4A3,ITGA3,RHOB,PLA2G5,LUM,CAV1,TXN,GSK3B,CXCL8,HEYL,MIF,SPP1,ATF3,COMP,ADAMTS1,TNFRSF10B,MMP2,BCL2L1,CDH5,HIF1AN,mir-21,RBP4,ADM,ADAM17,LEP,DDIT3,PSMB10,FGF2,ABL1,ADIPOQ,TNFSF10,TNFAIP3,SMPD1,MEOX2,HMOX1,ALDH2,NFKBIA,EDN1,RGS5,THBS1,MCAM,PRKCE,S100A8,SEMA3B,COL18A1,MAPKAPK2,PLAT,AGT,SRC,UCP2,ANGPT1,CXCR4,AXL,CAT,PROCR,KDR,MMP9	67	
Cancer, Organismal Injury and Abnormalities	growth	growth of malignant tumor	1.64E-10	 	-0.119	 	-1.539	CTGF,HRAS,MST1,TLE1,IL6,SPI1,ODC1,PEG10,CCND3,LUM,CAV1,AHCY,MCL1,ATG7,NDRG1,PYGO2,DVL2,TIMP4,ASGR1,CDH5,BSG,BTG2,CTSB,ITGA1,SFRP1,SQSTM1,CYR61,DUS2,NOTCH1,mir-21,NRP1,ADM,MME,FHL1,RALA,DDIT3,BTG3,FGF2,LEPR,GDF15,ADIPOQ,CDK4,TNFSF10,RUVBL1,TAX1BP3,EIF4EBP1,ID1,MTOR,JUN,CCL2,CSF2RA,CST3,PRKCE,ACVR1C,PLAT,FCER2,SOX7,MGMT,EGR1,ID3,GRN,FOS,NR4A2,S100A9,PIN1,PTGS2,BMP6,MAOA,SOCS3,TFF3,TNFRSF4,ADRBK1,SPHK2,CXCL12,DIRAS1,GPC3,MYC,TGFBR2,PLCE1,RHOB,GSK3B,RET,CSF3R,CXCL8,PFKFB3,NOX4,MIF,SPP1,BAMBI,VEGFC,AKR1B10,INHBB,BCL2L1,CBX1,NOL3,ITGAM,DUSP1,APCDD1,PRKCD,IGFBP3,RGN,CCL18,AKR1B1,ESR1,MAP2K5,LOX,LITAF,SFRP2,LEP,BMP2,PKM,ABL1,EMX2,HIF1A,CCL3,NGF,NELFE,HDGF,EDN1,THBS1,MCAM,SMO,KIT,ERBB2,MCRS1,AGT,BEX2,SRC,COX17,CXCR4,PLAUR,BTK,RCAN1,ADGRG1,KDR,MMP9	136	
Protein Synthesis	metabolism	metabolism of protein	1.81E-10	 	1.829	 	0.033	CSTA,AXIN1,CTSG,GSAP,IL6,ODC1,TYSND1,NSF,EIF4EBP3,EIF3B,CTSH,P3H1,TSC2,CAV1,ATF4,KAT2A,ALDH3A1,DPH6,MAD2L2,THOP1,RHBDD1,HSPA8,CTSA,MRPL17,PPP1R15A,BTG2,TRPC4AP,CTSB,GAPDH,SQSTM1,PLTP,SAMD4A,EIF3K,TUFM,APOE,EIF4EBP2,DDIT3,FGF2,DPM2,ADIPOQ,CDK4,DDX3X,TGM2,TIPARP,ASPH,HELZ,MRPL12,TOB1,CSTB,FOS,ZFPM2,SWAP70,LDLR,CBS/CBSL,FAM129A,LYN,TPP1,TP53BP1,MAP3K8,SOX9,PIN1,SOCS3,HSPA1A/HSPA1B,DPP7,OGFOD1,HSPA5,GPC3,MYC,CTSD,CCT5,CAST,NEDD4L,CHMP1A,CPNE1,STXBP1,PSMB5,AURKAIP1,EIF4E2,BCL2L1,GIPC1,EDEM1,IGFBP3,AGAP3,NAGLU,CAPN2,VHL,UBE2I,UBXN1,TMEM88,SFTPD,HOMER2,MRPL15,BMP2,TPR,ABCF1,ATF6,INPPL1,HNRNPK,VPS4A,EDN1,F8,STUB1,ERBB2,LONP1,ATP13A2,AGT,PATL1,SRC,C4BPB,PLAUR,CANX,DNAJC1,PSME3,SERPINE2,HRSP12,CAPNS1,CAT,EIF3C,APOB,ELANE,SH3GLB1,NCSTN,EIF6,NCBP2,PCOLCE,RAD23A,LGMN,RARA,ANK2,DNAJA3,APTX,PEX6,ATG7,NANOS1,PCSK5,RRBP1,DKC1,THY1,CPA3,SERINC1,MMP2,JUNB,IER3,APEH,TAF9B,STIP1,KIAA0368,CCT3,MAP2K3,SFRP1,CAPRIN1,BACE2,NOTCH1,ANG,DUS2,PHLPP1,ADM,MME,SORL1,FYN,ADAM17,ZFP36,CRTAP,TNFSF10,FKBP1A,CASP4,H2AFZ,SF3B3,EIF4EBP1,UCHL1,SPPL2B,MTOR,TADA3,DHPS,JUN,GBA,CST3,SOCS2,NAALAD2,PSMD14,SARS,HGS,AMFR,PLAT,RPS24,CTSK,ADRM1,AZIN1,LRSAM1,RELN,CYP1B1,YBX2,MRPL51,LAMP2,TF,S100A9,CHFR,IGF2BP2,DVL3,PFN1,ADRBK1,VPS28,CD4,PIGQ,SDC4,LOC102724828/MRPL23,CCT8,METAP2,TNIP1,CNDP2,EIF5,SIAH2,GSK3B,D2HGDH,GPC1,KLF2,ADRA1B,EIF2AK1,SPP1,FST,PCSK7,FBXO22,ST6GALNAC3,MARS,EPRS,MMP23B,SNX1,XPNPEP1,RCE1,RNPEP,ADAMTS7,RNF165,LEP,ERN1,SLC7A1,TNFAIP3,MRPL2,MAN1B1,FBXO3,AKIP1,PDCD4,SOX17,IPO9,CSPG4,THBS1,FLNA,SMO,RPS6KB2,ARHGEF2,NCL,CHEK2,PRNP,RHBDD3,MIPEP,C9orf3,SMAD7,PERP,SCIN,MKNK2,NDUFA13,FAF1,WARS,TSPAN1,RPS27L,CPZ,RNMTL1,CPEB1,P2RX7,MMP9	269	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	central nervous system tumor	central nervous system tumor	1.94E-10	 	0.163	 	0.042	AXIN1,ANKRD20A4 (includes others),ASCC2,IL6,ATP2A2,CLIP1,AJUBA,MCOLN3,TSC2,LUM,SMARCB1,MGP,CAV1,HES6,HIPK2,SLCO2B1,TSHZ2,WASH3P,ALDOC,SELE,COCH,LHPP,TNFRSF10B,TFPI2,HSPA8,PYGO2,DVL2,MN1,BTG2,ALCAM,TRAPPC5,mir-21,ZDHHC4,CD163L1,NME1,GBP1,FGF2,GNA11,GDF15,CDK4,DDX3X,DTNA,RAD21,CYP51A1,MECOM,TJP1,EMP3,ID3,HSPA2,GRN,KIF7,LDLR,NTRK3,FLNC,TAGLN,SOX9,ABCC3,BMP6,KTN1,FOXRED1,RARRES2,PTTG1,MBP,KLF6,DIRAS1,HSPA5,BIN1,GPNMB,MYC,TGFBR2,KCNAB1,FAR2,RPAP1,TEK,PFKFB3,CXCL8,H19,VEGFC,PTGDS,KLF4,CYB561,BCL2L1,ABCA8,H3F3A/H3F3B,DBNDD1,BUD31,BAP1,AGAP3,ESR1,VHL,RAB11FIP5,FEM1A,DENND4B,DCAF4,GIMAP6,IRAK1,HLA-G,MSRB3,HLA-DRB1,COL6A1,TIMP1,ENPP2,ERBB2,CIZ1,RBPMS,SRC,VCAM1,NLRP3,SLC12A2,GNAI1,DLEU1,NUP210L,ATIC,CXCL16,VAV3,CAT,SPARC,COL11A1,MAP4K4,ITSN1,CA12,HRAS,CDKN2C,RAPH1,HOXA9,RNF38,PRG4,RARA,ANK2,MGAT4B,VEGFD,IRS2,PKIA,ALPK1,MCL1,POLR2I,CAPN5,PIK3C2B,SV2B,PLEC,HBEGF,GRK5,MMP2,MBD2,TNK2,FAM86B1,DOCK1,CCND2,MS4A7,ASPHD2,RSU1,SFRP1,NOTCH1,DHRS4,COL3A1,NRP1,SPTBN1,AKAP12,HIST2H2AA3/HIST2H2AA4,MAP7,HIST1H1C,GSTM5,HYOU1,TNFSF10,FKBP1A,H2AFZ,IDH1,MTOR,TARS2,CSF2RA,PRKCE,COL22A1,MYO1D,PCBP2,AHNAK2,PTK7,DNAH6,MYCN,PLXNA1,CD209,SLC25A13,ANGPT1,IMPDH2,MGMT,NBEA,SLIT2,RELN,EMC1,POLD1,COL5A3,RHPN2,CLDN5,TF,S100A9,SBF1,BMF,CBX4,TAZ,AOX1,PTGS2,CHD7,SPNS1,SERPINI1,CLTB,SPHK2,TMEM147,CXCL12,ZNF91,COBL,DHTKD1,TMEM156,CYP4X1,KPNA2,GOT1,GSK3B,RET,TRIM5,PTX3,CSF3R,AXIN2,TRIOBP,SPP1,EGR3,ALAD,GSR,PPP2R1A,PRKCD,RGN,CLCN7,RNPEP,ADAMTS7,PA2G4,ATF5,FLRT2,PCMT1,BCL2L12,PKM,ABL1,IRF3,HIF1A,CDKN2B,COL1A2,SOX17,EPHB6,CSPG4,THBS1,FLNA,DKK3,KCNMA1,SMO,KIT,CYGB,NR2F6,CTDNEP1,CHEK2,ACTN1,ZFP42,BEX2,SNAPC4,CXCR4,CPED1,LRRK2,RAPGEF5,CSF1R,ANO2,SYBU,COL1A1,LPAR1,LRP1B,GAP43,C6,ELK1,KDR,MMP9	274	
Dermatological Diseases and Conditions	psoriasis	psoriasis	2.01E-10	 	0.447	 	0.333	CSTA,SGK1,TGFBR3,RAN,GARS,POMC,IL6,EIF6,MTX1,ATP2A2,ODC1,POR,ITGA3,GNA15,CCND3,RARA,KEAP1,RAB38,ABCC1,SPTLC2,CAV1,VEGFD,SELE,CDKN1C,NAB1,MT1X,MMP2,JUNB,THBD,IFNAR2,HAX1,HSPA8,AQP9,CCND2,FSCN1,CTSB,GAPDH,MAP2K3,ATOX1,ITGA1,PCBD1,mir-21,NRP1,EPHX1,ADM,APOE,SQLE,ADAM17,ZFP36,GBP1,PSMB10,PPP1R3C,ACKR2,CEBPD,FKBP1A,CRAT,CASP4,H2AFZ,LAMP3,IFI27,EIF4EBP1,EFNB2,ID1,MTOR,JUN,GBA,CCL2,ALDH1A3,IL17D,CD24,PCBP2,GJB2,FCGR3A/FCGR3B,PLAT,GSTM1,CTSK,EGR1,GPM6B,PSMB6,CSTB,CYP1B1,OTUB1,FOS,NR4A2,LDLR,TF,S100A9,CNN1,ANXA3,TAGLN,ARHGDIA,PTGS2,ID4,RGS1,CD4,MBP,CD36,CLEC3B,IL17RC,TYMP,TAF10,ZNF91,HSPA5,TUBB,METAP2,TNIP1,PGD,G0S2,CRIP1,ALDH3A2,EIF5,FAR2,CCT5,KPNA2,GOT1,C1QBP,TEK,CXCL8,MIF,ICA1,IER2,GM2A,LAMA2,PSME2,EIF2S2,PKN1,BCL2L1,ABCA8,DUSP1,FAM26F,IGFBP3,IDO1,CRABP2,S100P,UBE2I,RBP4,SRM,FRZB,PCMT1,PKM,RARRES1,TNFAIP3,ELOVL3,ME1,HIF1A,RGS12,IRAK1,COL1A2,HLA-G,HMOX1,SHC1,RAB5A,CSPG4,MCAM,HSPE1,MT1L,PSMA3,S100A8,GOT2,VCAM1,PKP1,RGS20,TUBG1,UPP1,F13A1,IL20RB,THRSP,APOC1,KDR,GAPVD1,RCAN2,P2RX7,ISG20,MMP9,RER1	175	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral cancer	oral cancer	2.03E-10	 	 	 	 	CSTA,BMP4,SERPINI1,CTGF,CXCL12,HRAS,PCDH7,TPM1,IL6,GPC3,MYC,CYP26B1,ITGA11,CTSH,RAB38,CXCL14,NPTX2,MGP,TUBA1C,MCL1,IGFBP6,CXCL8,DPT,MTSS1,MFAP5,TUBB2A,THBD,HAX1,BCL2L1,H3F3A/H3F3B,BSG,MATN2,DUSP1,IGFBP3,IFIT2,PDGFD,S100P,SULF1,MAP7,EMILIN2,PKM,PPP1CB,TNFSF10,CTHRC1,ITGA10,COL15A1,SPON1,TGM2,ADSL,CCL8,TIMP1,SRGN,EGFL6,S100A8,ERBB2,GPC6,G3BP2,THBS4,SPRY1,TYROBP,TUBG1,DAAM1,DPAGT1,ATIC,F11R,COL1A1,EBF1,S100A9,LPAR1,CNN1,TAGLN,CILP,COL11A1,PTGS2,ING1,CXCL2,KDR,DSG2,TM4SF1	79	
Cardiovascular Disease	vascular lesion	vascular lesion	2.13E-10	 	-0.446	 	-0.522	SOCS3,APOB,ACAT2,PFN1,CD4,PLA2G15,LIPE,C1QA,ARG2,IL6,SDC4,MYC,TGFBR2,CEL,IKBKG,PLA2G5,MGP,KLF2,PTX3,ELN,MIF,SELE,SPP1,MFAP5,PCSK5,RRBP1,SGCB,MMP2,THBD,ADRA2A,ESR1,VHL,mir-21,COL3A1,ADM,RUNX1,LOX,APOE,LEP,ZFP36,ADIPOQ,TNFSF10,TNFAIP3,MYLK,MYH11,EFNB2,HMOX1,SHC1,NFKBIA,CCL2,CCL3L3,TIMP1,THBS1,CST3,MKL2,LIPG,COL18A1,PTGER4,AGT,CCR1,VCAM1,CTSK,COL5A2,CD59,ATP2C1,EGR1,PLA2G2A,CXCL16,RCAN1,COL1A1,LDLR,CBS/CBSL,ACAT1,EDNRA,SPARC,PTGS2,KDR,CXCL2,EFEMP2,MMP9	80	
Skeletal and Muscular System Development and Function	morphology	morphology of muscle	2.17E-10	 	 	 	 	TGFBR3,CACNA1H,IL6,ATP2A2,GTF2IRD1,PCOLCE,POR,IDUA,MKX,GAA,LUM,MGP,CAV1,HEY2,HADHA,CASQ2,HEYL,CALCRL,CAPN6,PLEC,HBEGF,MMP2,HMGA1,IER3,PLOD1,DOCK1,CDH2,MAP2K3,MAPK7,NOTCH1,ITGA7,SPTBN1,APOE,ADAM17,ADIPOQ,CDK4,FKBP1A,MYH11,MEOX2,COL15A1,TGM2,DTNA,TNMD,STIM1,PLOD3,MYH1,HEY1,SOX7,MYCN,COL12A1,TK2,IGF2R,PLA2G4A,ZFPM2,FLNC,MAN2B1,ADRBK1,CLIP3,CXCL12,BIN1,CAMK2D,GPR4,KLF2,ACTA1,ELN,FST,DNASE2,PKP2,SGCG,EGR3,LAMA2,H6PD,SGCB,ANO1,MYOF,BCL2L1,TLN2,SRPK3,ALDH1A2,TMOD1,SUN1,LOX,ABL1,HIF1A,RAMP2,SHC1,CD55,COL6A1,EDN1,THBS1,MKL2,RPS6KB2,IFRD1,ACADM,ALPL,PAK4,VCAM1,CXCR4,MTMR14,EMD,RCAN1,ITPA,ACADVL,VAV3,EDNRA,XK,RCAN2,EFEMP2	108	
Cardiovascular System Development and Function, Cellular Movement	movement	movement of vascular endothelial cells	2.18E-10	 	-1.841	 	-3.442	BMP4,CD36,CXCL12,SDC4,HSPA5,HOXA9,TGFBR2,NEU1,OSR1,STAB1,GSK3B,KLF2,CXCL8,PIK3C2B,ARHGEF4,SELE,ADAMTS1,MTSS1,THY1,VEGFC,THRA,THBD,FOXC1,S1PR3,ORM1,CDH5,ARHGEF6,RTN4,MDK,CYR61,MAP2K5,NRP1,ADM,CNN2,LOX,LEP,FGF2,GNA11,PKM,ADIPOQ,TNFSF10,HIF1A,MEOX2,EFNB2,ID1,EDN1,TIMP1,THBS1,SAA1,ENPP2,ERBB2,COL18A1,NCL,SRC,ANGPT1,TJP1,SLIT2,ID3,F11R,PLA2G4A,VAV3,S1PR1,SPARC,PTGS2,KDR,MMP9	66	
Cellular Assembly and Organization, Tissue Development	formation	formation of filaments	2.22E-10	 	1.401	 	-0.772	BMP4,MSRB2,CTGF,SGK1,HRAS,SERPINA3,SLC9A1,CLIP1,ITGA3,BOP1,GLB1,MYADM,KANK3,CAV1,MAP1A,TESK1,SELE,MTSS1,CARMIL1,THY1,MMP2,JUNB,HAX1,CORO7/CORO7-PAM16,PTPRA,FYN,APOE,FHL1,FGF2,GNA11,WASF3,CDK4,MSRB1,MYH11,COL5A1,MTOR,CCL2,SORBS1,RHOD,STARD13,DAB2,PRKCE,TUB,TBCD,PIK3R2,GNG5,COL18A1,ADORA1,NCKIPSD,PLAT,SLIT2,RELN,ARHGEF5,MYOC,PLEKHG6,WAS,SERPINH1,SPRY2,S1PR1,FKBP4,PIN1,PFN1,ITGB1BP1,MICALL2,MBP,MAP1B,CLIP3,CXCL12,FCER1A,RGCC,TPM1,SDC4,CDC42EP2,HSPA5,COBL,TUBB,TGFBR2,ADGRF5,RHOB,MYOM1,GPR4,GSK3B,KLF2,ACTA1,ELN,CXCL8,NOX4,MIF,PKP2,GNG2,PTGDS,MLST8,UBXN11,LMCD1,KANK1,CDC42BPB,COL6A3,PRKCD,ARL2,LEP,TPR,ABL1,INPPL1,MYLK,PHLDB2,RAP1GDS1,EDN1,NET1,ARHGEF2,ASAP3,PTGER4,AGT,SRC,VCAM1,NUSAP1,PKP1,PAK4,RTKN,PLAUR,SH3PXD2A,KCTD13,LPAR1,EDNRA,SPARC,GAP43,NCKAP1L,KDR	127	
Inflammatory Disease	chronic inflammatory disorder	chronic inflammatory disorder	2.54E-10	 	-0.322	 	0.061	HLA-DOA,CTSG,CACNA1H,TLE1,C1QA,CLSTN2,IL6,EEF1G,SKIV2L,POR,IP6K3,CYBA,ATF4,ECHDC1,TNFRSF21,CERS6,PTGIS,RBM38,SELE,COMP,TNFRSF10B,MSMO1,THOP1,IFNAR2,HSPA8,TMEM127,HLA-DRB4,VARS2,NCF2,CTSB,TFRC,CD86,FTH1,APOE,COL4A5,GADD45B,DDIT3,FGF2,ADIPOQ,ZBTB9,C1R,SPON1,CCL2,IL17D,PGA5 (includes others),ADORA1,CYP51A1,FCGR3A/FCGR3B,CCR1,S100A1,TJP1,CD69,DGAT2,SPATS2L,TK2,GRN,FOS,HP,NR4A2,PROCR,ADRA1A,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,TRPM8,TYMP,HSPA5,TGFBR2,PADI4,CTSD,CARD8,CXCL14,EEF1E1,STAB1,VNN2,CXCL8,PSMB5,CAPG,PPP1R11,THRA,ORMDL3,FOSB,BCL2L1,H3F3A/H3F3B,ADRA2A,DUSP1,SLC7A2,NAGLU,FZD5,MDK,C2,RBP4,IGFBP4,FRZB,TPGS2,CCL3,HLA-G,HLA-DRB1,EDN1,TIMP1,MCAM,SAA1,VARS,AGT,SRC,VCAM1,NLRP3,PLAUR,HCG9,ATIC,CXCL16,PMP22,PHF19,VAV3,SMG7,CXCL2,MAP4K4,COX15,PRUNE2,KCND2,BMP4,ELANE,POMC,GSS,HSD17B8,NR4A3,GAA,TXN,MCL1,PPIL6,CALCRL,HBEGF,GRK5,MMP2,THBD,APEH,AQP9,CD68,BSG,PSMB2,MS4A7,IL10RA,ALDOA,GLUL,ALAS2,ANG,COL3A1,ADM,MME,SORL1,FCGRT,SQLE,ADAM17,SCAP,ZFP36,TNFSF10,ST6GALNAC4,FKBP1A,ATAT1,GPC4,UCHL1,MTOR,LYZ,JUN,CCL3L1,CCL8,CST3,CSF2RA,PDE3B,SLC19A1,PRKCE,CD24,LBP,FUK,RPS24,CYP11A1,STK19,C5AR1,IMPDH2,TRIM28,CINP,BRMS1,ACLY,AXL,POLD1,GABRE,PLA2G2A,GLIPR2,F11R,KRT8,TF,S100A9,WAS,TENM4,S1PR1,CELF2,MS4A2,NR5A2,PTGS2,VPS52,RGS1,TFG,CD36,CD4,CXCL12,IL17RC,SDC4,NRSN2,IKBKG,CAMK2D,G0S2,UQCC2,LPIN2,LTBR,ARL16,GCA,WDR46,ADRA1B,ACTA1,PHACTR3,CSF3R,MIF,HNMT,SPP1,DNASE2,CYYR1,LMO4,GSR,C1QTNF6,PRKCD,SLC22A5,ASIC1,IDO1,CCL18,ADAMTS7,LEP,PRDX5,PKM,SLC7A1,TNFAIP3,SIL1,NGF,RAMP2,NELFE,EVC,COL1A2,HMOX1,NFKBIA,CCL13,THBS1,CFB,S100A8,MAPKAPK2,ALPL,CHEK2,PTGER4,ADRB2,PRNP,CD59,MIPEP,CXCR4,SMAD7,VSIG4,LRRK2,PRMT1,FAF1,COL1A1,ENO1,ITPA,DIP2C,LRP1B,DYM,MMP9	276	
Cellular Movement	chemotaxis	chemotaxis	3.06E-10	 	-0.708	bias	-4.562	CTGF,BMP4,ELANE,CTSG,HRAS,MST1,SERPINA3,IL6,HOMER3,SPI1,HOXA9,ABCC1,TSC2,CAV1,VEGFD,TXN,CMKLR1,SELE,PLEC,HBEGF,ANO6,FLOT1,MMP2,THBD,NINJ1,S1PR3,AQP9,PIP5K1C,YARS,RTN4,ITGA1,CYR61,PDGFD,NRP1,APOE,FYN,ADAM17,RALA,DAPK2,FGF2,GNA11,ACKR2,G6PC3,EFNB2,TRIB1,MTOR,JUN,CCL3L1,CCL8,CCL2,CCL3L3,CST3,RHOD,CSF2RA,RHOU,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CSK,CD69,ANOS1,DEFB1,SLIT2,BRMS1,AXL,IGF2R,GRN,HP,SWAP70,LDLR,CBS/CBSL,S100A9,NTRK3,WAS,SERPINH1,LSP1,LYN,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,SOCS3,TFF3,ADGRA2,RARRES2,PFN1,ADRBK1,CD36,CD4,SPHK2,CXCL12,HARS,TYMP,RHOB,OSR1,CXCL14,C1QBP,CLCN3,TEK,MARCO,CSF3R,ELN,CXCL8,MIF,SPP1,APLNR,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,ARHGEF16,PRKCD,SCRIB,CAPN2,MDK,CCL18,LOX,LITAF,SFTPD,LEP,BMP2,ABL1,MYLK,NGF,CCL3,GLRX,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,SEMA3B,MAPKAPK2,PRNP,AGT,THBS4,SRC,VCAM1,MMP28,CXCR4,LRRK2,PLAUR,CSF1R,TNFRSF14,CXCL16,LPAR1,VAV3,EDNRA,KDR,CXCL2,NCKAP1L,MMP9	165	
Organismal Development	abnormal morphology	abnormal morphology of body cavity	3.16E-10	 	 	 	 	SYTL2,RRM2B,CACNA1H,IL6,SLC35C1,SPI1,ATP2A2,TYSND1,POR,IDUA,CCND3,BCAT2,LUM,MTHFD2,MGP,CAV1,ATF4,NABP2,UNG,CASQ2,AMHR2,ETS1,PTGIS,RBM38,SELE,MTSS1,MAD2L2,GPX7,PYGO2,DVL2,IFT122,CTSA,CDH5,PPP1R15A,ATMIN,CD86,ITGA1,APOE,SLC4A2,FGF2,CFC1/CFC1B,GDF15,CDK4,ADIPOQ,CTHRC1,HEXA,TGM2,GADD45GIP1,GADD45A,LY6E,DAB2,CYP51A1,HEY1,CCR1,TSTA3,MECOM,SPRY1,MESP1,SLCO2A1,AGL,TK2,IGF2R,ID3,GRN,FOS,PLA2G4A,HP,ZFPM2,LDLR,CBS/CBSL,NTRK3,GPBAR1,LYN,ARHGDIA,SOX9,MAP3K8,MAN2B1,BMPER,SGCD,LIG1,SOCS3,PTTG1,ABCA3,ZFPM1,GPC3,BIN1,CEBPG,MYC,TGFBR2,CTSD,ADGRF5,GPR4,NUPR1,NEDD4L,BIRC3,TEK,MARCO,ELN,NOX4,ATF3,PKP2,ADAMTS1,DOK2,MAPK8IP2,THRA,DCHS1,KLF4,NOL3,DUSP1,ALDH1A2,IGFBP3,NAGLU,CAPN2,H1F0,MEGF8,ESR1,TXNRD2,TNS1,VHL,RBP4,SUN1,RUNX1,IGFBP4,LOX,SFTPD,SRPX,ZP3,BMP2,CADPS2,ETV6,CIAPIN1,SHC1,SLC19A3,DHCR7,EDN1,MKL2,ERBB2,AGT,SLC20A1,SRC,VCAM1,DHRS3,EPN1,SLC12A2,NQO1,G6PD,EMD,SNX27,BSCL2,KIF3B,NFE2L1,BTK,RCAN1,XYLT2,ACADVL,VAV3,ING1,PLIN1,CTGF,BMP4,TGFBR3,TYRO3,CDKN2C,MST1,NCSTN,APRT,ITGA3,DMRT2,LGMN,GAA,RARA,IRS2,HEY2,HADHA,MCL1,CALCRL,CMKLR1,ZC3HC1,CENPB,FANCG,PLEC,HBEGF,MMP2,IER3,HMGA1,THBD,S1PR3,DOCK1,CDH2,TIMP4,CCND2,BSG,MAPK7,NOTCH1,NRP1,COL3A1,B9D1,ADM,AKAP12,SPTBN1,HIST1H1C,FYN,ADAM17,ZFP36,SRD5A1,FKBP1A,ABCA5,MYH11,VTI1B,EFNB2,TRIB1,MCOLN1,ID1,CES1,JUN,GBA,CST3,SLC19A1,ACSL4,PRKCE,RASSF5,COL18A1,CYP11A1,MYCN,SOX7,CTSK,EGR1,MGMT,AXL,POLD1,COPS3,YBX2,LAMP2,KRT8,WAS,LIMS1,BMF,SPRY2,FCER1G,FKBP4,NR5A2,DBNL,BNIP3L,DVL3,PTGS2,ZFP36L2,ARID4A,RGS1,TFF3,ADRBK1,FAT1,CD36,CD4,PLA2G15,LHCGR,SDC4,RSPO3,IKBKG,PLCE1,COMT,OSR1,GSK3B,LTBR,RET,CLCN3,KLF2,ADRA1B,EIF2AK1,PTX3,MIF,SPP1,DNASE2,SGCG,LMNA,PAWR,FZD9,MAPK8IP3,ERCC1,PKD1,PRKCD,SCRIB,RGN,AKR1B1,NFIX,FLRT2,ANTXR1,ABL1,SMPD1,HIF1A,RAMP2,CDKN2B,HMOX1,AEBP1,MAN2C1,CD55,NFKBIA,ANGPTL4,THBS1,FLNA,SMO,CFB,RPS6KB2,HSD11B2,HCST,HMGCL,ALPL,ACADM,PTGER4,PAK4,EPAS1,CXCR4,AQP11,MTMR14,HYAL1,SMAD7,LRRK2,NFKBIZ,CSF1R,COL1A1,ITPA,EPHB3,EDNRA,GBE1,RCAN2,CARM1,MMP9	326	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	autosomal dominant myopathy	autosomal dominant myopathy	3.37E-10	 	 	 	 	LOX,TGFBR3,GARS,HIF1A,TAX1BP3,TGFBR2,COL1A2,COL5A1,PLS3,COL6A1,EGR2,AHNAK,DHTKD1,DAB2,STIM1,TBCD,EMILIN1,COL5A2,COL6A2,TUBB2A,MTMR14,LMNA,ACLY,CYB561,COL1A1,PMP22,COLEC12,SDCBP,COL6A3,FLNC,SERPINH1,S1PR1,CELF2,SPARC,BNIP3L,RSU1,AARS,DNAJB6,COL3A1	39	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	endocrine gland tumor	endocrine gland tumor	3.61E-10	 	1.858	 	2.406	CBX7,AXIN1,ASS1,NOMO1 (includes others),IL6,POLRMT,POR,IDUA,EIF3B,CCND3,GLB1,POMZP3,TSC2,PLXNB2,ETS1,COMP,CTSB,C15orf39,mir-21,RABL6,NAXE,ATN1,MECOM,THEM6,GPAM,KIF7,SOCS3,C2CD4B,DPYSL4,ANKMY1,ZFPM1,AP1B1,INTS1,TUBA1C,TEK,KMT5A,MAN1C1,ADAMTS1,H6PD,STX1A,AKR1B10,FAAP20,BCL2L1,ADRA2A,FAM26F,C17orf97,BAIAP2L2,VHL,SUN1,RAB11FIP5,UBE2I,ZP3,BMP2,FLRT1,ALDH2,SH3PXD2B,EDN1,ISCU,ERBB2,FAAP100,NLRP3,PYGB,SAA2,ING1,COL11A1,FCGBP,PRUNE2,DDX11,MST1,BCAS4,POMC,HOMER3,MIA,NR4A3,ITGA3,MED16,SFRP4,PIK3C2B,DKC1,PLEC,CEP89,HMGA1,CORO7/CORO7-PAM16,FAM86B1,ISLR,CCZ1/CCZ1B,NOTCH1,TMEM158,AKAP12,SUSD2,FCGRT,ZFP36,FKBP1A,RCOR2,TMEM259,TUSC5,ATP6AP1,C20orf96,CES1,CST3,RNF135,FUK,HGS,AHNAK2,PLXNA1,ANKRD9,EGR1,BHLHE22,ARHGAP4,WDR18,SLIT2,AXL,RELN,GABRE,RBM42,SBF1,UAP1L1,PTGS2,TFF3,TNFRSF4,MAP1B,UNC5B,LHCGR,CLEC3B,FAM173A,DHTKD1,GPC1,GSK3B,RET,MT1G,TRIOBP,CYYR1,MTURN,PCDHA1,GALNT13,TPSAB1/TPSB2,UBXN11,KIAA0922,FLCN,CCDC184,SORD,LRRC41,RAP1GAP,FRYL,C2orf40,SCRIB,CLCN7,AMY1C (includes others),SFRP2,ATF5,MAN1B1,PTPRF,THBS1,ARHGEF35,CDCA5,EXOSC7,RHBDD3,ADRB2,EPAS1,BHLHE41,PARP10,DHX37,PLBD2,PLEKHH1,FAM46A,EPHB3,CPZ,MYPOP,KDR,XK,CLEC10A,SLIT3,HCAR3,SVEP1,MAP6,WBSCR22,CACNA1H,ANKRD20A4 (includes others),ASCC2,MTX1,CLIP1,ODC1,TYSND1,GATAD2A,NUP93,RAB38,CEP170B,ALDOC,RRP1,SELE,PODN,RAB3IL1,LAMC3,IFNAR2,AEN,WDR81,ZNF579,TMEM127,MN1,NCF2,CHD1L,TRAPPC5,SLC4A2,CHCHD10,ZNF205,FGF2,GDF15,CDK4,CEBPD,THOC3,CKAP4,HS3ST3A1,TGM2,CHDH,GADD45A,PGA5 (includes others),IRF2BPL,HCAR2,FCGR3A/FCGR3B,FCER2,MAPKAP1,GLRX2,RCCD1,ARHGEF5,FOS,HP,NRXN2,SERPINH1,LRRC75B,TAGLN,BMPER,MAP3K8,ABCC3,ID4,ADRA1A,FOXRED1,TPPP3,KIAA1551,RTN1,PTTG1,HSPA1A/HSPA1B,DPP7,RNASE1,C16orf91,MYC,TGFBR2,ZNF598,PDCD6,CHTF18,PDZRN3,KIF25,LRBA,MYDGF,CLIP2,THRA,KCNK12,DCHS1,ABCA8,ORM1,GIPC1,SOBP,ALDH1A2,IGFBP3,CAPN2,ESR1,PMEPA1,RBP4,POLR3F,FDX1L,FRZB,SF3B5,SCARA5,TPGS2,NEURL4,SLC2A3,IRAK1,HLA-DRB1,RGS5,AHNAK,TIMP1,HES4,VARS,MCRS1,GJA4,NUSAP1,VCAM1,APBB1IP,SLC22A12,ZNF358,TUBG1,PWWP2B,CXCL16,CLGN,LOC102724788/PRODH,IRF2BP2,TACC2,PHF19,IVD,KCNK15,CDKN2C,HRAS,CLCNKA,SLC16A2,IRS2,PEX6,ARRDC4,PCSK5,RRBP1,TUBB2A,THY1,MMP2,PLOD1,CRABP1,CCDC170,CCND2,ASGR1,CDRT1,ADAMTS18,ASPHD2,LRP8,MAP2K3,ZER1,ITGA7,BOD1,SPTBN1,MME,ALDH4A1,SCAP,PAM16,PFKL,IDH1,UCHL1,ID1,EFNB2,MTOR,SRGAP1,ANXA5,DAP3,SLC19A1,PRKCE,SH3GLB2,RASSF5,TPO,COL18A1,SF3A2,PI4KA,GSTM1,MYCN,YBX2,RHPN2,FAM86C1,RBM6,LIMS1,SLC25A19,DENND1A,ZSCAN18,S1PR1,ALS2CL,FBN2,PHLDA1,ADSSL1,C10orf54,PTPN23,DCAKD,SDC4,TSEN54,LTBR,ADRA1B,PDK4,CSF3R,CRISPLD2,STAG3L2/STAG3L3,SPP1,PANK1,PKD1,CUEDC1,ADAMTSL2,LSM7,AKR1B1,AK2,RNPEP,ADAMTS7,LEP,PRDX5,PKM,CDH23,ABL1,RARRES1,SMPD1,HIF1A,CDKN2B,HMOX1,ADSL,TMEM119,AEBP1,KCNMA1,CSPG4,KIT,HSD11B2,S100A8,ARHGEF2,CUL9,CTDNEP1,MYO16,RAB11FIP3,TMEM132B,FRMD1,CXCR4,RNF126,SCIN,CSF1R,NDUFA13,FIZ1,URM1,LRP1B,ZNF585A,ELK1,DSG2,ALG1L,MMP9	420	
Cardiovascular System Development and Function, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Organismal Development, Tissue Development	proliferation	proliferation of endothelial cells	3.65E-10	 	-0.667	 	-1.747	BMP4,KCNJ2,SERPINA3,IL6,CYBA,MGP,CAV1,VEGFD,HIPK2,HEYL,C1GALT1C1,HBEGF,THY1,CDH2,CTSB,ITGA1,ANG,NRP1,ADM,APOE,GBP1,FGF2,SEMA6A,ADIPOQ,TNFSF10,ID1,EFNB2,MTOR,JUN,CCL2,DAB2,PRKCE,TNMD,COL18A1,HEY1,ANGPT1,ZNF580,EGR1,AXL,GRN,F11R,PLA2G4A,S100A9,PPP1R16B,ATP6V0A2,PROCR,BMPER,PTGS2,BMP6,CD36,ITGB1BP1,CXCL12,RGCC,SDC4,METAP2,MYC,TGFBR2,PDCD6,GPC1,GSK3B,KLF2,TEK,CXCL8,PFKFB3,ADAMTS1,MYDGF,EGR3,STK39,VEGFC,MYOF,ATPIF1,PRKCD,ALDH1A2,HIF1AN,FZD5,MDK,SULF1,LEP,ERN1,BMP2,PKM,HIF1A,TNFRSF12A,HMOX1,ANGPTL4,RGS5,EDN1,THBS1,SAA1,KIT,S100A8,AGT,THBS4,G6PD,PLAUR,CSF1R,EDF1,RCAN1,SPARC,KDR,RCAN2	101	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	benign neoplasm of female genital organ	benign neoplasm of female genital organ	3.77E-10	 	 	 	 	RPE,AHCYL1,CMTM4,MAF,CDKN2C,ACP5,PPP4C,NR4A3,CYBA,KEAP1,MTHFD2,MGP,PKIA,WNT5B,TSHZ2,SLC2A5,ALDH1B1,CALCRL,CAPN6,DPT,PLD3,NDRG1,SLC24A3,NDUFS7,MFAP5,MMP2,PARP3,TFPI2,AP2S1,SPINT2,ALDOA,TRO,LRP8,HSPB7,SFRP1,CYR61,NOTCH1,mir-21,FTH1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,APOE,NOL7,GSTM5,UQCRH,PHLDA2,FGF2,COL15A1,VCAN,EIF4EBP1,DTNA,MTOR,JUN,CMTM8,DAB2,CD24,ECM2,RAD21,PI4KA,MECOM,DDX24,SLIT2,STXBP6,CYP1B1,FOS,ZFPM2,NR4A2,LSP1,LYN,XAF1,NR5A2,SEMA3C,PTGS2,ADRA1A,MAOA,SOCS3,MEGF9,PTTG1,PARP2,LHCGR,RGCC,CLEC3B,MYC,TGFBR2,GPX3,ALDH1A1,DHTKD1,SDPR,CXCL14,ERAL1,ADRA1B,PDK4,AXIN2,SPP1,HNMT,H19,ERCC2,RPL9,KCNG1,PPP2R1A,ABCA8,COL6A3,ADRA2A,ALDH1A2,BAP1,CRABP2,AK2,ESR1,POLR3F,IGFBP4,SCARA5,FLRT2,PKM,SLC7A1,RAMP2,EPHB6,GNG11,RGS5,MCAM,KIT,MICALL1,RNF144B,CHEK2,ADRB2,DLGAP4,HYAL1,LRRK2,CLEC16A,C2orf88,VAV3,LPAR5	131	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of cancer cells	3.94E-10	 	0.124	 	-1.122	TLE1,MST1,HRAS,IL6,SPI1,ODC1,PEG10,CCND3,LUM,CAV1,AHCY,ATG7,NDRG1,PYGO2,DVL2,BSG,CDH5,BTG2,CTSB,ITGA1,SFRP1,SQSTM1,CYR61,DUS2,NOTCH1,mir-21,NRP1,FHL1,DDIT3,FGF2,GDF15,ADIPOQ,CDK4,TNFSF10,RUVBL1,TAX1BP3,EIF4EBP1,ID1,MTOR,JUN,CSF2RA,CST3,PRKCE,ACVR1C,FCER2,PLAT,SOX7,MGMT,EGR1,ID3,GRN,FOS,NR4A2,S100A9,PIN1,PTGS2,SOCS3,TFF3,TNFRSF4,ADRBK1,SPHK2,DIRAS1,GPC3,MYC,PLCE1,RHOB,GSK3B,RET,CSF3R,CXCL8,PFKFB3,NOX4,MIF,SPP1,BAMBI,VEGFC,INHBB,BCL2L1,CBX1,NOL3,DUSP1,APCDD1,PRKCD,IGFBP3,RGN,AKR1B1,ESR1,MAP2K5,LOX,LITAF,SFRP2,LEP,BMP2,ABL1,EMX2,HIF1A,CCL3,NGF,NELFE,HDGF,EDN1,THBS1,MCAM,SMO,KIT,ERBB2,MCRS1,AGT,BEX2,SRC,COX17,PLAUR,BTK,RCAN1,KDR,MMP9	116	
Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development	cardiogenesis	cardiogenesis	4.03E-10	 	-0.052	 	-1.195	BMP4,TGFBR3,HRAS,NCSTN,IL6,ATP2A2,POR,IDUA,GYS1,CCND3,GAA,RARA,TSC2,CAV1,HEY2,MYL3,CASQ2,HEYL,CALCRL,PCSK5,PLEC,HBEGF,MMP2,THBD,S1PR3,DVL2,CCND2,PIP5K1C,STIP1,NPRL3,MAPK7,CYR61,NOTCH1,mir-21,NRP1,COL3A1,ADM,SPTBN1,APOE,ADAM17,FHL1,CFC1/CFC1B,GNA11,SIN3B,GDF15,CDK4,FKBP1A,MYH11,VCAN,COL5A1,ID1,MTOR,JUN,SOS1,LY6E,GNG5,NCKIPSD,CYP51A1,HEY1,PTK7,MYCN,MECOM,ANGPT1,DAAM1,MESP1,TMED2,IGF2R,ID3,KRT8,ZFPM2,KIF7,CBS/CBSL,NTRK3,LIMS1,S1PR1,DVL3,SOX9,TAZ,SEMA3C,CHD7,ADRA1A,ADRBK1,CXCL12,ZFPM1,TPM1,AP1B1,GPC3,BIN1,MYC,TGFBR2,CAMK2D,PLCE1,CRIP1,MAP2K2,ASXL2,OSR1,GSK3B,FZD2,TEK,ADRA1B,KCNJ8,APLNR,PKP2,LMO4,SGCG,THRA,DCHS1,FOXC1,PKD1,DUSP1,ALDH1A2,SLC22A5,DNAJB6,MEGF8,TMOD1,TXNRD2,MAP2K5,RBP4,LOX,LEP,BMP2,FLRT2,ABL1,CLUAP1,MYLK,HIF1A,AKIP1,RAMP2,SOX17,HMOX1,SHC1,SH3PXD2B,EDN1,THBS1,FLNA,SMO,MKL2,KIT,HSD11B2,ERBB2,ACADM,ADRB2,AGT,VCAM1,DHRS3,PAK4,CXCR4,SMAD6,SMAD7,CAPNS1,ITPA,EDNRA,COL11A1,DNM1L,MMP9	155	
Skeletal and Muscular System Development and Function	abnormal morphology	abnormal morphology of muscle	4.25E-10	 	 	 	 	TGFBR3,CACNA1H,IL6,ATP2A2,GTF2IRD1,PCOLCE,POR,IDUA,MKX,GAA,LUM,MGP,CAV1,HEY2,HADHA,CASQ2,HEYL,CAPN6,CALCRL,PLEC,HBEGF,MMP2,HMGA1,IER3,PLOD1,DOCK1,CDH2,MAPK7,NOTCH1,ITGA7,SPTBN1,APOE,ADAM17,ADIPOQ,CDK4,FKBP1A,MYH11,MEOX2,COL15A1,TGM2,TNMD,MYH1,HEY1,SOX7,MYCN,COL12A1,TK2,IGF2R,PLA2G4A,ZFPM2,FLNC,MAN2B1,ADRBK1,CLIP3,CXCL12,BIN1,CAMK2D,GPR4,KLF2,ACTA1,ELN,FST,DNASE2,PKP2,SGCG,EGR3,LAMA2,H6PD,SGCB,ANO1,MYOF,TLN2,SRPK3,ALDH1A2,SUN1,LOX,ABL1,HIF1A,RAMP2,SHC1,CD55,COL6A1,EDN1,THBS1,MKL2,RPS6KB2,IFRD1,ACADM,ALPL,PAK4,VCAM1,CXCR4,MTMR14,EMD,RCAN1,ITPA,ACADVL,VAV3,EDNRA,RCAN2,XK,EFEMP2	102	
Cardiovascular Disease, Organismal Injury and Abnormalities, Reproductive System Disease	preeclampsia	preeclampsia	4.48E-10	 	 	 	 	SLIT3,CBX7,MAP6,COL8A1,ADGRL1,ATP2A2,SLC39A8,CLCNKA,NPTX2,MARCH2,MGP,EARS2,TMEM97,MCL1,PTGIS,APTX,DBP,GUCY1A3,KIAA1147,HIGD1B,MSMO1,RANBP3,CCDC136,PDE1B,PRELP,ATMIN,MUSTN1,FKBP2,EPHX1,FHL1,GDF15,TRPT1,FAXDC2,GPIHBP1,COL16A1,KLF9,CST3,CLEC14A,OSBPL11,NAALAD2,ALG8,ABHD4,CYP11A1,CEP164,APBB3,COL12A1,PLA2G2A,MYOC,LDLR,LMO3,NTRK3,PTGS2,MXRA5,RBP5,SGCD,HAGH,ADRA1A,MAOA,RARRES2,LHCGR,PLEKHG4,TMED5,ADGRF5,ITGA11,MOCOS,ALDH3A2,PLA2G5,ACTG2,MYO10,ADRA1B,NOX4,FMO2,SRPRB,C3orf18,PPP1R14A,VEGFC,OSBPL7,DCHS1,FOXC1,GSR,MMP23B,ADRA2A,DNAJB6,ESR1,DOCK6,TMOD1,PMEPA1,TEF,AOC3,NFIX,SRPX,NLGN1,TPR,UBASH3B,ATF6,NGF,MSRB3,TMEM119,HMOX1,OLFML2A,KIAA0040,XPNPEP2,NSMF,MYO16,ADRB2,GJA4,AGT,CCDC50,SPOCD1,MMP28,ATP2C1,SNTB1,DAAM2,CCDC85A,FAM49A,TRIM69,CIART,PMP22,POLR3B,DNAJB11,OLFML2B,SPARC,NUCB2,RDH5,KDR,ALKBH3	126	
Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	autosomal dominant Emery-Dreifuss muscular dystrophy	autosomal dominant Emery-Dreifuss muscular dystrophy	4.48E-10	 	 	 	 	LOX,TGFBR3,HIF1A,TAX1BP3,TGFBR2,COL5A1,COL1A2,PLS3,COL6A1,DAB2,TBCD,EMILIN1,COL5A2,COL6A2,TUBB2A,LMNA,ACLY,CYB561,COL1A1,COLEC12,SDCBP,COL6A3,SERPINH1,CELF2,S1PR1,BNIP3L,SPARC,RSU1,COL3A1	29	
Neurological Disease, Skeletal and Muscular Disorders	neuromuscular disease	neuromuscular disease	4.60E-10	Increased	2.170	 	2.370	RRM2B,ZNF239,SERPINA3,IL6,ATP2A2,MT1E,EGR2,CSE1L,GPRC5C,PPRC1,KEAP1,ATF4,TACO1,CASQ2,AHCY,FBL,COCH,PPP1R1B,SURF1,FLOT1,PTPN3,IFNAR2,HSPA8,PDLIM7,PSMA4,GAPDH,CD86,ALCAM,SLC27A1,SQSTM1,FTH1,EIF3K,RNF10,APOE,NME1,GBP1,DDIT3,FGF2,SCUBE2,TUBB2B,TGM2,DTNA,DUSP5,MAL2,CCL2,GADD45A,LY6E,CSNK2B,ADORA1,CYP51A1,FCGR3A/FCGR3B,MLF2,TRIB3,GPM6B,PSMB6,ID3,MYO5A,FOS,GPAM,HP,NR4A2,LDLR,SOX9,PIN1,ID4,ADRA1A,MT2A,ATP2B1,RTN1,HAVCR2,MBP,HSPA1A/HSPA1B,MT1M,HSPA5,AK1,KCNAB1,STRN4,TUBA1C,RASGRP2,PSMB5,LAMA2,BCL2L1,H3F3A/H3F3B,ADRA2A,DNAJB6,NDUFS3,SYN1,ETV5,RBP4,PEBP1,FAM107A,SLC1A4,SRPX,COPE,ADH1C,EMX2,GTF3A,HLA-G,ALDH2,DHCR7,SUCLA2,HLA-DRB1,STUB1,MCAM,CRYM,ATP13A2,AGT,PSAT1,AP1S2,SMAD6,CANX,DNAJC1,ATP6V1E1,RCAN1,KCTD13,PMP22,CAPNS1,DNAJB11,NREP,COX15,KCND2,GFPT1,CTGF,AHCYL1,SGK1,RAN,CA12,HRAS,PCDH7,GHITM,TXN,PKIA,POLR2I,CDKN1C,NDRG1,DBP,SLC24A3,CHN1,MT1X,THY1,JUNB,IER3,NGRN,MAP3K12,CDH2,NR1D1,CD68,PDE1B,RTN4,SORL1,FCGRT,ADAM17,NDUFA7,SRD5A1,NQO2,SLC1A3,KAZN,FKBP1A,THBS3,CORO2B,VCAN,UCHL1,CA3,MTOR,STOM,JUN,GBA,CST3,MYOM2,IMPDH2,EGR1,DPAGT1,NBEA,SLIT2,AXL,GABRE,F11R,LAMP2,UQCR10,FKBP4,S1PR1,DBNL,PTGS2,SYN2,SERPINI1,PFN1,PFKFB1,MAP1B,CXCL12,DNAJB2,SDC4,DYNLT1,FAM173A,CYP26B1,SLC25A6,COMT,GSK3B,HLA-F,ADRA1B,MT1G,MIF,SPP1,APLNR,ICA1,GPS2,USP36,LMCD1,ITGAM,RAP1GAP,C2orf40,RARRES3,IDO1,SRM,SH3BP4,LEP,HIGD1A,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,NGF,NELFE,HMOX1,RAB5A,AEBP1,CD55,HINT1,DKK3,KCNMA1,MT1L,C7,CFB,MICALL1,ACADM,ADRB2,PRNP,ATP2C1,LRRK2,DAAM2,SGTA,PLSCR4,NDUFA13,VAMP1,CYC1,ACAT1,GAP43,UQCRC1,P2RX7,ATP6V1B2	250	
Cellular Movement, Skeletal and Muscular System Development and Function	migration	migration of vascular smooth muscle cells	5.11E-10	 	-1.223	bias	-2.749	ADM,IGFBP4,ADAMTS7,FHL1,LEP,ADRBK1,FGF2,BMP2,CDK4,TNFSF10,IL6,SDC4,MEOX2,RAMP2,PTPRF,HMOX1,CAMK2D,CCL2,TIMP1,THBS1,NEO1,TXN,GSK3B,AGT,ELN,CXCL8,CALCRL,COMP,SPP1,ATF3,EGR1,NQO1,PLAUR,TFPI2,CYP1B1,RCAN1,S1PR1,RTN4,RAMP3,PTGS2,KDR,mir-21	42	
Dermatological Diseases and Conditions, Inflammatory Disease, Skeletal and Muscular Disorders	juvenile dermatomyositis	juvenile dermatomyositis	5.54E-10	 	 	 	 	LOX,TGFBR3,HIF1A,TAX1BP3,TGFBR2,COL5A1,COL1A2,PLS3,COL6A1,DAB2,TBCD,EMILIN1,COL5A2,COL6A2,TUBB2A,ACLY,CYB561,COL1A1,COLEC12,SDCBP,COL6A3,SERPINH1,CELF2,S1PR1,BNIP3L,SPARC,RSU1,COL3A1	28	
Cell-To-Cell Signaling and Interaction, Cellular Movement	recruitment	recruitment of cells	6.32E-10	 	-1.952	bias	-4.423	CAMK1,APOB,CTSG,ELANE,IL6,SGPL1,CAV1,TXN,HEY2,ETS1,CMKLR1,SELE,ATG7,COCH,FLOT1,THY1,MMP2,NINJ1,CARD9,PIP5K1C,RTN4,MAP2K3,SFRP1,MAPK7,CYR61,NOTCH1,CNN2,APOE,ADAM17,FGF2,GDF15,ADIPOQ,EFNB2,LYZ,MTOR,JUN,CCL2,CCL3L3,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,C5AR1,ANGPT1,CD69,EGR1,HDC,SLIT2,CYP1B1,FOS,LY96,SWAP70,LSP1,PELI1,LYN,S1PR1,MAP3K8,PTGS2,ST3GAL4,RARRES2,LAMTOR2,CD36,CD4,HSPA1A/HSPA1B,CXCL12,FCER1A,GPC3,TGFBR2,RHOB,TEK,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SPP1,ORMDL3,TPSAB1/TPSB2,ITGAM,CD14,IDO1,MDK,SLC11A1,AOC3,SFTPD,LEP,PLGRKT,HIF1A,IRF3,CCL3,GLRX,HMOX1,SHC1,NFKBIA,EDN1,THBS1,S100A8,AGT,VCAM1,NLRP3,MMP28,CXCR4,ST3GAL6,LRRK2,F13A1,CSF1R,RCAN1,CXCL16,VAV3,CAT,CXCL2,KDR,MMP9	114	
Cancer, Organismal Injury and Abnormalities	metastasis	metastasis	6.52E-10	 	0.076	 	-1.008	KCNJ2,IL6,POR,CTSH,CSE1L,CAV1,SELE,TNFRSF10B,IFNAR2,HAX1,FSCN1,CTSB,CD86,ALCAM,SQSTM1,PTPRA,mir-21,APOE,NME1,FGF2,HCAR1,GDF15,CDK4,CEBPD,CTHRC1,FNTA,TGM2,C1R,CCL2,GADD45A,TRIM29,HCAR2,FCGR3A/FCGR3B,CYP51A1,SLC12A8,OLFML3,ID3,FOS,LYN,TP53BP1,ABCC3,QPCT,SOCS3,AKR1C3,RTN1,PTTG1,KLF6,PARP2,RNASE1,MYC,TGFBR2,ADGRF5,RHOB,MAP2K2,HDAC11,STAB1,TUBA1C,PDZRN3,TEK,CXCL8,ATF3,ADAMTS1,VEGFC,CAPG,ERCC2,BCL2L1,NOL3,SDCBP,FAM26F,CAPN2,DNAJB6,ESR1,RUNX1,ERAP2,LOX,SRPX,BMP2,EMX2,GLRX,GSTT1,EDN1,TIMP1,MCAM,LOC102724428/SIK1,RNH1,ENPP2,ERBB2,SRC,VCAM1,TUBG1,PLAUR,ATIC,BTK,CLGN,VAV3,CAT,CXCL2,DPYD,BMP4,CTGF,TGFBR3,HRAS,CDKN2C,GYG2,ACP5,HOXA9,PCOLCE,MIA,ITGA3,PLS3,DGCR6L,MTUS1,VEGFD,NDRG1,GSTM3,TUBB2A,THY1,MMP2,TNK2,MBD2,PARP3,HMGA1,THBD,ROR1,CDH2,ISLR,COLEC12,CCND2,ASGR1,GLUL,MAP2K3,SFRP1,MAPK7,CYR61,NOTCH1,NRP1,ADM,AKAP12,MME,FYN,ADAM17,MSC,ZFP36,TCEA1,NID2,SRD5A1,HYOU1,FKBP1A,VCAN,ENAH,IDH1,ID1,MTOR,CCL8,CST3,ANXA5,CD24,PRKCE,STIM1,COL18A1,PLAT,MYCN,C5AR1,IMPDH2,MGMT,EPB41L4B,SLIT2,BRMS1,AXL,RELN,POLD1,CYP1B1,KRT8,WAS,CNN1,PTGS2,ZFP36L2,NEDD9,TM4SF1,FZD7,FBN2,CD36,LHCGR,CXCL12,DNAJB2,TUBB,LTBR,C1QBP,RET,CLCN3,PTX3,CSF3R,MIF,FST,SPP1,LMCD1,GSR,EFS,PPP2R1A,ERCC1,COL6A3,SCRIB,LSM7,CRABP2,EPB41L3,FLRT2,ABL1,GPR34,HIF1A,TNFRSF12A,PDCD4,HMOX1,NFKBIA,ANGPTL4,FLNA,THBS1,SMO,KIT,RNF144B,HCST,ALPL,PRNP,EPAS1,BHLHE41,CXCR4,SMAD7,PLSCR4,CPA4,CSF1R,NDUFA13,PRMT1,EMP1,FAF1,NEK11,KDR,DSG2,MMP9	237	
Carbohydrate Metabolism	quantity	quantity of carbohydrate	7.65E-10	 	1.176	 	0.246	GFPT1,ASPSCR1,CTGF,BMP4,CA5B,VAC14,HRAS,C1QA,IL6,ATP2A2,IDUA,LPIN1,BCAT2,GAA,SPTLC2,ABCC1,CAV1,ATF4,IRS2,RGL1,CERS6,ATG7,CIDEC,CPA3,AQP9,PIP5K1C,PPP1R15A,GAPDH,ACACA,ADIPOR2,ADM,APOE,SCAP,LEPR,FGF2,PPP1R3C,GDF15,CDK4,ADIPOQ,TNFSF10,CTHRC1,HEXA,G6PC3,MTOR,CES1,PDE3B,DCXR,PLIN2,ANXA5,LIPG,LBP,PIK3R2,ABCC9,PI4KA,MBOAT7,TSTA3,SLC25A13,ABHD5,FMO3,UCP2,MGMT,RGS16,DGAT2,CDO1,BRMS1,AGL,TK2,GPAM,PLA2G4A,LDLR,FCER1G,IGF2BP2,PTGS2,NDST2,ADRA1A,PFKFB1,C2CD4B,CD36,PTTG1,ABCA3,LIPE,ABCG1,SDC4,HSPA5,GUSB,MYC,TGFBR2,CEL,ALDH1A1,ACP6,CXCL14,GSK3B,C1QBP,CLCN3,KLF2,TEK,ACTA1,ADRA1B,PDK4,HK1,CXCL8,MIF,SPP1,ICA1,ITPR2,LMNA,H6PD,FIG4,THRA,GNAZ,STX1A,TPSAB1/TPSB2,SLC3A2,PANK1,ERCC1,ADRA2A,PKD1,HIF1AN,IGFBP3,CD14,ESR1,CCDC80,VHL,IGFBP4,DDAH2,SFTPD,LEP,RPH3AL,SMPD1,INPPL1,ATF6,HIF1A,NGF,WDR13,HINT1,MAN2C1,EDN1,CFB,RPS6KB2,ENPP2,STK40,ACADM,PI4KB,PTGER4,AGT,LCLAT1,NQO1,SMAD6,BSCL2,THRSP,CIDEA,DGKQ,ACADVL,APOC1,GBE1,NUCB2,PNPLA6,MMP9	158	
Cellular Movement	chemotaxis	chemotaxis of cells	1.01E-09	 	-0.717	bias	-4.534	CTGF,BMP4,ELANE,CTSG,HRAS,MST1,SERPINA3,IL6,HOMER3,SPI1,HOXA9,ABCC1,TSC2,CAV1,VEGFD,TXN,CMKLR1,SELE,PLEC,HBEGF,ANO6,FLOT1,MMP2,THBD,NINJ1,S1PR3,AQP9,YARS,PIP5K1C,RTN4,ITGA1,CYR61,PDGFD,NRP1,APOE,FYN,ADAM17,DAPK2,FGF2,GNA11,ACKR2,G6PC3,TRIB1,MTOR,JUN,CCL3L1,CCL8,CCL2,CCL3L3,CST3,CSF2RA,RHOU,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CSK,CD69,DEFB1,SLIT2,BRMS1,AXL,IGF2R,GRN,HP,SWAP70,LDLR,CBS/CBSL,S100A9,NTRK3,WAS,SERPINH1,LSP1,LYN,FCER1G,S1PR1,PTGS2,NEDD9,RGS1,SOCS3,TFF3,RARRES2,PFN1,ADRBK1,CD36,CD4,SPHK2,CXCL12,HARS,RHOB,OSR1,CXCL14,C1QBP,CLCN3,TEK,MARCO,CSF3R,ELN,CXCL8,MIF,SPP1,APLNR,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,ARHGEF16,PRKCD,SCRIB,CAPN2,MDK,CCL18,LOX,LITAF,SFTPD,LEP,BMP2,ABL1,MYLK,NGF,CCL3,GLRX,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,KIT,ENPP2,S100A8,ERBB2,SEMA3B,MAPKAPK2,PRNP,AGT,THBS4,SRC,VCAM1,MMP28,CXCR4,LRRK2,PLAUR,CSF1R,TNFRSF14,CXCL16,LPAR1,VAV3,EDNRA,KDR,CXCL2,NCKAP1L,MMP9	159	
Neurological Disease, Psychological Disorders	disorder of basal ganglia	disorder of basal ganglia	1.02E-09	 	-1.455	bias	-0.825	ZNF239,SERPINA3,IL6,ATP2A2,MT1E,EGR2,CSE1L,PPRC1,GPRC5C,CAV1,ATF4,CASQ2,AHCY,FBL,COCH,PPP1R1B,FLOT1,PTPN3,HSPA8,PDLIM7,GAPDH,SLC27A1,EIF3K,FTH1,RNF10,APOE,NME1,GBP1,DDIT3,FGF2,SCUBE2,TUBB2B,TGM2,DTNA,DUSP5,GADD45A,MAL2,ADORA1,ATN1,CYP51A1,MLF2,TRIB3,PSMB6,ID3,MYO5A,GPAM,FOS,HP,NR4A2,LDLR,C19orf12,SOX9,PIN1,ID4,ADRA1A,MT2A,ATP2B1,RTN1,MBP,HSPA1A/HSPA1B,MT1M,HSPA5,AK1,KCNAB1,STRN4,TUBA1C,RASGRP2,FOSB,BCL2L1,H3F3A/H3F3B,ADRA2A,DNAJB6,NDUFS3,SYN1,ETV5,RBP4,PEBP1,FAM107A,SLC1A4,SRPX,ADH1C,COPE,EMX2,GTF3A,SLC19A3,ALDH2,SUCLA2,DHCR7,STUB1,CRYM,ATP13A2,PSAT1,AP1S2,TUBG1,SMAD6,DNAJC1,ATP6V1E1,RCAN1,KCTD13,PMP22,CAPNS1,NREP,CTGF,AHCYL1,WDR45,SGK1,CA12,RAN,PCDH7,HRAS,GHITM,PNKD,TXN,PKIA,POLR2I,CDKN1C,NDRG1,DBP,CHN1,MT1X,TUBB2A,THY1,JUNB,IER3,RNASEH2A,NGRN,MAP3K12,CDH2,NR1D1,CD68,PDE1B,RTN4,RNASEH2C,SORL1,NDUFA7,SRD5A1,NQO2,SLC1A3,KAZN,THBS3,CORO2B,VCAN,UCHL1,STOM,JUN,GBA,MYOM2,EGR1,NBEA,SLIT2,GABRE,F11R,LAMP2,SLC25A19,UQCR10,FKBP4,S1PR1,DBNL,PTGS2,SYN2,SERPINI1,PFN1,PFKFB1,MAP1B,DNAJB2,SDC4,DYNLT1,FAM173A,CYP26B1,SLC25A6,COMT,GSK3B,ADRA1B,MT1G,SPP1,APLNR,ICA1,GPS2,USP36,LMCD1,ITGAM,RAP1GAP,C2orf40,RARRES3,IDO1,SRM,SH3BP4,LEP,HIGD1A,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,NGF,HMOX1,RAB5A,AEBP1,HINT1,DKK3,MT1L,C7,MICALL1,ACADM,PRNP,ADRB2,LRRK2,DAAM2,SGTA,PLSCR4,NDUFA13,VAMP1,CYC1,ACAT1,PDE8B,GAP43,UQCRC1,ATP6V1B2	218	
Organismal Injury and Abnormalities, Reproductive System Disease	disorder of pregnancy	disorder of pregnancy	1.03E-09	 	-1.938	 	-1.301	SLIT3,CBX7,DDX11,MAP6,COL8A1,IL6,ATP2A2,ADGRL1,SLC39A8,CLCNKA,NPTX2,MARCH2,MGP,EARS2,TMEM97,MCL1,PTGIS,APTX,DBP,GUCY1A3,KIAA1147,HIGD1B,MSMO1,RANBP3,S1PR3,CCDC136,PDE1B,PRELP,ATMIN,MUSTN1,FKBP2,EPHX1,ADM,NME1,FHL1,GDF15,TRPT1,FAXDC2,ATP6AP1,GPIHBP1,COL16A1,KLF9,CST3,ANXA5,CLEC14A,OSBPL11,NAALAD2,ALG8,FCGR3A/FCGR3B,ABHD4,CYP11A1,CEP164,APBB3,COL12A1,PLA2G2A,MYOC,LDLR,LMO3,NTRK3,SERPINH1,PTGS2,MXRA5,RBP5,SGCD,HAGH,ADRA1A,MAOA,RARRES2,LHCGR,PLEKHG4,MYC,TMED5,ADGRF5,ITGA11,MOCOS,ALDH3A2,PLA2G5,ACTG2,MYO10,ADRA1B,CSF3R,NOX4,H19,FMO2,SRPRB,C3orf18,PPP1R14A,VEGFC,OSBPL7,DCHS1,FOXC1,GSR,MMP23B,ADRA2A,PKD1,GPS1,DNAJB6,ESR1,DOCK6,TMOD1,TEF,RNPEP,PMEPA1,AOC3,NFIX,SRPX,NLGN1,TPR,UBASH3B,ATF6,NGF,IRAK1,MSRB3,TMEM119,HMOX1,OLFML2A,KIAA0040,XPNPEP2,HSD11B2,NSMF,MYO16,PTGER4,ADRB2,GJA4,AGT,CCDC50,SPOCD1,MMP28,ATP2C1,SNTB1,F13A1,DAAM2,CCDC85A,FAM49A,TRIM69,CIART,PMP22,POLR3B,DNAJB11,OLFML2B,SPARC,NUCB2,RDH5,KDR,ALKBH3	145	
Tissue Development	growth	growth of connective tissue	1.06E-09	 	0.919	 	-1.239	CBX7,CTGF,BMP4,ITSN1,TYRO3,HRAS,CDKN2C,NCSTN,IL6,SPI1,SGPL1,CCND3,RARA,SMARCB1,P3H1,TSC2,LUM,CAV1,ATF4,TXN,HIPK2,WNT5B,NAB1,NDRG1,TNFRSF10B,DKC1,HBEGF,MMP2,JUNB,HMGA1,TNK2,MN1,CCND2,NPR3,CTSB,IL10RA,MAP2K3,ITGA1,SFRP1,CYR61,PDGFD,NOTCH1,FTH1,PHLPP1,ADM,AKAP12,FYN,LEPR,FGF2,CDK4,ADIPOQ,TNFSF10,CTHRC1,VCAN,IDH1,EFNB2,KLF9,B4GALT7,JUN,GADD45A,CCL2,IL34,TNMD,PIK3R2,HGS,PLAT,MYCN,PTPRK,MECOM,TYROBP,CSK,GRN,FOS,TF,S100A9,NTRK3,SERPINH1,SPRY2,PTGS2,BMP6,LIG1,SOCS3,TFG,PTTG1,HSPA1A/HSPA1B,SPHK2,CXCL12,TPM1,SDC4,CD163,MYC,TGFBR2,CTSD,IKBKG,PLCE1,RHOB,NUPR1,RET,ELN,IGFBP6,CXCL8,NOX4,MIF,APLNR,SPP1,FST,ATF3,BTG1,LMNA,PAWR,THRA,FOXC1,KLF4,INHBB,RASD1,SLC3A2,FOSB,STC1,BCL2L1,CCNG2,TLN2,DUSP1,PRKCD,LIMA1,IGFBP3,IDO1,GNL3,RCE1,ESR1,TXNRD2,VHL,TNFAIP8,RUNX1,SULF1,IGFBP4,LOX,SFTPD,LEP,PA2G4,BMP2,TPR,ABL1,SMPD1,HIF1A,NGF,CDKN2B,ETV6,PTPRF,TNFRSF12A,HDGF,HMOX1,TMEM119,AEBP1,HINT1,NFKBIA,CCL13,EDN1,TIMP1,DKK3,KCNMA1,SAA1,SMO,KIT,ERBB2,RNF144B,MAPKAPK2,SULF2,AGT,SRC,PARP10,SMAD6,SMAD7,EMD,PLAUR,SERTAD1,CSF1R,PSME3,ATIC,BTK,COL1A1,CAPNS1,LPAR1,VAV3,EDNRA,SPARC,ELK1,DNM1L,DSG2,MMP9	189	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	central nervous system cancer	central nervous system cancer	1.08E-09	 	-0.132	 	0.023	AXIN1,CDKN2C,ANKRD20A4 (includes others),IL6,ATP2A2,HOXA9,AJUBA,TSC2,SMARCB1,MGP,CAV1,VEGFD,IRS2,PKIA,HIPK2,MCL1,TSHZ2,POLR2I,PIK3C2B,LHPP,MMP2,MBD2,FAM86B1,DOCK1,DVL2,CCND2,BTG2,ASPHD2,ALCAM,RSU1,SFRP1,NOTCH1,mir-21,TRAPPC5,DHRS4,COL3A1,NRP1,AKAP12,HIST2H2AA3/HIST2H2AA4,MAP7,HIST1H1C,NME1,GBP1,GNA11,CDK4,DDX3X,IDH1,DTNA,MTOR,RAD21,MYCN,MECOM,ANGPT1,TJP1,EMP3,MGMT,NBEA,SLIT2,RELN,ID3,HSPA2,POLD1,CLDN5,TF,SOX9,CBX4,TAZ,PTGS2,CHD7,FOXRED1,SERPINI1,PTTG1,MBP,CLTB,KLF6,HSPA5,GPNMB,MYC,TGFBR2,KCNAB1,GOT1,GSK3B,RET,PTX3,CSF3R,PFKFB3,CXCL8,AXIN2,SPP1,EGR3,VEGFC,ALAD,PTGDS,CYB561,GSR,BCL2L1,ABCA8,H3F3A/H3F3B,BAP1,RGN,RNPEP,FEM1A,PA2G4,PCMT1,BCL2L12,PKM,ABL1,CDKN2B,IRAK1,COL1A2,SOX17,EPHB6,HLA-DRB1,TIMP1,CSPG4,THBS1,FLNA,KCNMA1,SMO,KIT,ENPP2,ERBB2,CTDNEP1,CHEK2,ACTN1,RBPMS,SRC,VCAM1,SLC12A2,GNAI1,LRRK2,DLEU1,RAPGEF5,ATIC,CXCL16,COL1A1,LPAR1,VAV3,LRP1B,GAP43,ELK1,KDR,MAP4K4,MMP9	144	
Cellular Assembly and Organization	formation	formation of cytoskeleton	1.09E-09	Increased	2.013	 	0.020	BMP4,MSRB2,CTGF,SGK1,HRAS,SLC9A1,CLIP1,ITGA3,BOP1,GLB1,MYADM,KANK3,CAV1,MAP1A,TESK1,SELE,MTSS1,CARMIL1,THY1,MMP2,JUNB,HAX1,CORO7/CORO7-PAM16,PTPRA,FYN,SLC4A2,FGF2,GNA11,WASF3,CDK4,MSRB1,MYH11,MTOR,CCL2,SORBS1,RHOD,STARD13,DAB2,PRKCE,TUB,TBCD,PIK3R2,GNG5,COL18A1,ADORA1,NCKIPSD,PLAT,SLIT2,RELN,ARHGEF5,COL5A3,MYOC,PLEKHG6,WAS,SPRY2,FKBP4,S1PR1,PIN1,PFN1,MICALL2,ITGB1BP1,MAP1B,CLIP3,CXCL12,FCER1A,RGCC,TPM1,SDC4,CDC42EP2,COBL,TUBB,MYC,TGFBR2,ADGRF5,RHOB,GPR4,GSK3B,KLF2,ELN,CXCL8,NOX4,MIF,GNG2,PTGDS,MLST8,UBXN11,LMCD1,KANK1,CDC42BPB,ERP29,PRKCD,ARL2,GDI1,LEP,ABL1,INPPL1,MYLK,PHLDB2,EDN1,NET1,FLNA,THBS1,ARHGEF2,ASAP3,PTGER4,AGT,SRC,VCAM1,NUSAP1,PAK4,RTKN,SH3PXD2A,KCTD13,LPAR1,EDNRA,SPARC,GAP43,NCKAP1L,KDR	119	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of neutrophils	1.11E-09	 	-1.295	 	-3.478	CTGF,CTSG,ELANE,IL6,SPI1,LUM,TXN,SELE,CMKLR1,FLOT1,THBD,AQP9,PIP5K1C,RTN4,CTSB,ITGA1,PLTP,SFRP1,ADM,CNN2,APOE,ADAM17,DAPK2,NQO2,ADIPOQ,CCL2,CCL8,CCL3L1,CSF2RA,CST3,CCL3L3,STIM1,LBP,ADORA1,GJB2,PLAT,CCR1,C5AR1,CD69,DEFB1,SLIT2,GRN,S100A9,WAS,LSP1,PROCR,FCER1G,LYN,MAP3K8,PTGS2,SOCS3,ADRBK1,CD36,UNC5B,CXCL12,TGFBR2,RSPO3,CXCL14,C1QBP,CAST,PTX3,CSF3R,CXCL8,SPP1,VEGFC,CAPG,TPSAB1/TPSB2,ITGAM,DUSP1,CD14,MDK,C2,TNFAIP3,MYLK,CCL3,HMOX1,CD55,NFKBIA,EDN1,TIMP1,SAA1,CFB,S100A8,ERBB2,MAPKAPK2,AGT,THBS4,VCAM1,NLRP3,NQO1,HYAL1,LRRK2,BTK,VAV3,EDNRA,NCKAP1L,CXCL2,MMP9	98	
Cardiovascular System Development and Function, Cellular Movement	migration	migration of vascular endothelial cells	1.13E-09	 	-1.675	 	-3.247	BMP4,CD36,CXCL12,SDC4,HSPA5,HOXA9,TGFBR2,NEU1,STAB1,GSK3B,KLF2,PIK3C2B,ARHGEF4,SELE,ADAMTS1,VEGFC,THY1,THRA,THBD,FOXC1,S1PR3,ORM1,CDH5,ARHGEF6,RTN4,MDK,CYR61,NRP1,ADM,CNN2,LOX,LEP,FGF2,GNA11,PKM,ADIPOQ,TNFSF10,HIF1A,MEOX2,EFNB2,ID1,EDN1,THBS1,TIMP1,SAA1,ERBB2,COL18A1,NCL,SRC,ANGPT1,TJP1,SLIT2,ID3,F11R,PLA2G4A,VAV3,S1PR1,PTGS2,KDR,MMP9	60	
Cardiovascular Disease	arteriosclerosis	arteriosclerosis	1.22E-09	 	0.603	 	-0.087	HCAR3,PLIN1,ACAT2,APOB,IL6,GSS,ATP2A2,SLC9A1,GAA,MGP,CAV1,CERS6,SELE,TUBB2A,MMP2,SCNN1D,JUNB,THBD,NPR3,VKORC1,RTN4,LRP8,PLTP,SAMD4A,APOE,ZFP36,GDF15,CCDC167,ADIPOQ,TNFSF10,FKBP1A,LRRC20,MTOR,CES1,JUN,CCL2,CCL3L3,SORBS1,CST3,PDE3B,PLIN2,LIPG,COL18A1,ADORA1,ABCC9,HCAR2,ALDH5A1,PLAT,CCR1,SIGMAR1,FMO3,MECOM,IMPDH2,EGR1,RNF157,DGAT2,GABRE,PLA2G2A,FOS,HP,MTHFD1L,SUPV3L1,LAMP2,LDLR,CBS/CBSL,S100A9,S1PR1,PTGS2,MSRA,SGCD,RGS1,SOCS3,PFN1,CD36,PLA2G15,KLF6,LIPE,ABCG1,ARG2,SDC4,CD163,TGFBR2,NNMT,CYP26B1,CEL,IKBKG,COMT,PLA2G5,TUBA1C,GCLM,BIRC3,KLF2,PTX3,ELN,KCNJ8,MIF,SPP1,SGCG,KLF4,FOSB,ITGAM,ADRA2A,MATN2,ASIC1,CD14,ESR1,ADAMTS7,LEP,ERN1,TNFAIP3,QPRT,HMOX1,SHC1,CD55,NFKBIA,EDN1,TIMP1,THBS1,SAA1,S100A8,MAPKAPK2,ADRB2,AGT,SNAPC4,VCAM1,PARVA,COL5A2,CD59,CYP27A1,ATP2C1,TUBG1,PLAUR,F13A1,FRMD4A,CXCL16,PBX3,ASTN2,APOC1,ACAT1,SPARC,GBE1,KDR,CXCL2,MMP9	144	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of lipid	1.23E-09	Increased	2.660	bias	-0.439	ACAT2,HACD1,CACNA1H,VAC14,IL6,ODC1,POR,TSC2,CAV1,CERS6,PTGIS,HSPA8,ACACA,SLC27A1,PLTP,BRE,APOE,FGF2,GDF15,DPM2,ADIPOQ,TECR,CCL2,SORBS1,PLIN2,DAB2,CYP51A1,DGAT2,TRIB3,PTDSS2,MYO5A,GPAM,PLA2G4A,FOS,NR4A2,LDLR,LYN,MAN2B1,MAP3K8,BMP6,CH25H,SOCS3,PIGU,RARRES2,AKR1C3,FCER1A,ABCG1,MYC,FAR2,MTMR2,NSMAF,CXCL8,ATF3,PEX7,ARSA,PTGDS,ORMDL3,ELOVL6,BCL2L1,ABCA8,ACBD6,ALDH1A2,ESR1,IGFBP4,HOMER2,KCNK3,BMP2,PTPMT1,ADH1C,ATF6,INPPL1,ME1,GCDH,DHCR7,EDN1,DECR2,ENPP2,ERBB2,AGT,G6PD,BSCL2,SERPINE2,PIGB,ACADVL,GAPVD1,PNPLA6,BMP4,APOB,PLIN1,SH3GLB1,POMC,HSD17B8,NR4A3,SGPL1,ITGA3,LPIN1,SPTLC2,ABCC1,LSS,TXN,PIK3C2B,SERINC1,MMP2,SERINC2,LARGE1,S1PR3,PLAA,NR1D1,DHRS9,PIP5K1C,ME2,ANG,HACD3,ADM,FYN,SCAP,PIGO,RALA,LEPR,SRD5A1,SLC1A3,TNFSF10,MTOR,CES1,GBA,ALDH1A3,ACSL4,CYP2R1,PI4KA,CYP11A1,CD209,ABHD5,C5AR1,ANGPT1,EGR1,HDC,DPAGT1,ACLY,PLA2G2A,CYP1B1,FAM213B,DHCR24,DENND1A,S1PR1,FCER1G,NR5A2,PTGS2,TAZ,MVD,PRPF19,ADRBK1,CD36,CD4,SPHK2,CXCL12,LHCGR,LIPE,PIGQ,CEL,PGD,PLCE1,ALDH1A1,PTGES2,PCYT2,PLA2G5,MID1IP1,GPC1,PDK4,PTX3,ACSL3,MIF,GPAA1,STC1,PRKCD,CD14,RGN,AKR1B1,LEP,PKM,C1QTNF1,ELOVL3,SMPD1,NGF,ACOT7,TNFRSF12A,HMOX1,NFKBIA,DKK3,KIT,CTDNEP1,PI4KB,PRNP,ADRB2,FAAH,CYP27A1,THRSP,IL18RAP,APOC1,ACAT1,EDNRA,PDE8B,RDH5,KDR,P2RX7,MMP9	205	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	uterine serous papillary cancer	uterine serous papillary cancer	1.26E-09	 	 	 	 	SLIT3,PRUNE2,PTTG1,TGFBR3,MAF,CLEC3B,CXCL12,IL6,RNASE4,TNIP1,ITGA3,ALDH1A1,LUM,SLC7A5,KPNA2,ACTG2,PDZRN3,FAM65B,TEK,PTGIS,CXCL8,SFRP4,DPT,ITM2A,GUCY1A3,MFAP5,RUNDC3B,CPA3,HMGA1,PLLP,CRABP1,TPSAB1/TPSB2,ABCA8,MATN2,SPINT2,SFRP1,COL3A1,AOC3,HIST1H1C,CDC20,FRZB,FLRT2,MYLK,MEOX2,MYH11,COL15A1,LAMP3,IRAK1,SYNM,UCHL1,RGS5,CSPG4,KCNMA1,SAA1,C7,CFB,SOCS2,ENPP2,ERBB2,LPP,ECM2,EMILIN1,THBS4,STON1,PLAUR,F13A1,MFAP4,PMP22,CLDN5,CBS/CBSL,CNN1,GALE,ANXA3,MS4A2,EDNRA,PDE8B,KDR	77	
Cell Morphology	cell spreading	cell spreading	1.33E-09	 	1.508	 	-0.448	SLIT3,PFN1,CD36,ITGB1BP1,CXCL12,HRAS,SERPINA3,TPM1,SDC4,DRG2,SLC9A1,CLIP1,PARVB,NSF,ITGA3,RHOB,MAP2K2,ITGA11,GSK3B,CAST,MYO10,TESK1,MATK,ETS1,FERMT3,CXCL8,SPP1,RRBP1,LAMA2,TNK2,DOCK1,ITGAM,RAP1GAP,RTN4,CAPN2,ITGA1,CYR61,ITGA7,PTPRA,VHL,CNN2,AKAP12,FGF2,GNA11,ANTXR1,STX6,SMPD1,INPPL1,NGF,IRAK1,SYNM,EPHB6,UCHL1,IPO9,MTOR,NET1,SORBS1,CSPG4,THBS1,RHOD,FLNA,PDE3B,PRKCE,DAB2,ERBB2,LPP,PRNP,FAAH,SRC,VCAM1,PAK4,PARVA,ANGPT1,CSK,PVR,IGF2R,BTK,SLK,PMP22,COL5A3,LPAR1,WAS,FLNC,SPRY2,VAV3,LYN,SPARC,GAP43,NEDD9,MAPRE3,MMP9	91	
Cellular Assembly and Organization	development	development of cytoplasm	1.34E-09	Increased	2.127	 	-0.036	MSRB2,BMP4,CTGF,SGK1,HRAS,SLC9A1,CLIP1,ITGA3,PEX16,BOP1,ATG9A,GLB1,MYADM,KANK3,CAV1,MAP1A,TESK1,PEX6,SELE,ATG7,MTSS1,CARMIL1,THY1,STOML2,MMP2,JUNB,MALSU1,HAX1,MRPL14,HSPA8,CORO7/CORO7-PAM16,NR1D1,EMC6,ATG101,PTPRA,ANG,FYN,APOE,SLC4A2,FGF2,GNA11,WASF3,CDK4,MSRB1,MYH11,MTOR,CCL2,SORBS1,RHOD,STARD13,TUB,PRKCE,DAB2,TBCD,PIK3R2,GNG5,COL18A1,ADORA1,NCKIPSD,PLAT,SLIT2,RELN,ARHGEF5,COL5A3,SUPV3L1,LAMP2,MYOC,PLEKHG6,WAS,SPRY2,S1PR1,FKBP4,PIN1,PFN1,ITGB1BP1,MICALL2,MAP1B,CLIP3,CXCL12,FCER1A,RGCC,TPM1,SDC4,CDC42EP2,TUBB,COBL,MYC,TGFBR2,CTSD,ADGRF5,RHOB,GPR4,GSK3B,KLF2,ELN,CXCL8,NOX4,MIF,GNG2,PTGDS,MLST8,UBXN11,LMCD1,KANK1,BCL2L1,CDC42BPB,ERP29,PRKCD,VHL,ARL2,GDI1,LEP,ABL1,MYLK,INPPL1,VPS4A,PHLDB2,RAB5A,IPO9,EDN1,NET1,THBS1,FLNA,ARHGEF2,ASAP3,PTGER4,AGT,SRC,VCAM1,PAK4,NUSAP1,IPO4,RTKN,SH3PXD2A,KCTD13,LPAR1,EDNRA,SPARC,GAP43,KDR,NCKAP1L,DNM1L	142	
Cancer, Organismal Injury and Abnormalities	solid tumor of head and neck	solid tumor of head and neck	1.38E-09	 	-0.658	 	0.170	CBX7,PCLO,AXIN1,NOMO1 (includes others),IL6,POLRMT,POR,IDUA,UPK3BL,CCND3,ATG9A,EIF3B,AJUBA,SMARCB1,TSC2,DEFB132,PLXNB2,WASH3P,ETS1,COMP,COCH,DVL2,KIAA0513,mir-21,CD163L1,GNA11,COL15A1,DDX3X,SYNM,SPON1,DTNA,GPC6,ATN1,MTSS1L,MECOM,EMP3,POLR1E,SPATS2L,PDZD2,GPAM,AFF3,KIF7,HNRNPH1,LYN,PROCR,SOX9,MXRA5,SOCS3,FAM136A,ARSD,AKR1C3,ANKMY1,ZFPM1,AP1B1,GPC3,CEP104,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,CPNE1,TEK,CXCL8,ADAMTS1,MAPK8IP2,RIMS4,LZTR1,ERCC2,UBL4A,KANK1,BCL2L1,H3F3A/H3F3B,ZNF296,DBNDD1,SLC7A2,C19orf54,BAP1,NAGLU,C17orf97,VHL,UBE2I,RAB11FIP5,SULF1,FEM1A,ZP3,FLRT1,ZNF252P,INPPL1,GIMAP6,HLA-G,DHCR7,COL6A1,EDN1,GTPBP2,ERBB2,THBS4,SRC,NDUFV1,NLRP3,PLAUR,PYGB,SAA2,FRMD4A,ORAOV1,POLR3B,COL11A1,ING1,CXCL2,FCGBP,PRUNE2,KCND2,DDX11,CTGF,BMP4,TYRO3,MST1,GYG2,POMC,HOMER3,EIF6,RNF38,SGPL1,ITGA3,PRG4,MTUS1,PNKD,MGAT4B,TESK1,MCL1,POLR2I,PPIL6,CAPN5,PIK3C2B,EFL1,TMEM37,NAB1,SV2B,PLEC,GRK5,CHI3L2,HMGA1,THBD,FAM86B1,ACAD11,CORO7/CORO7-PAM16,MAP3K12,CCZ1/CCZ1B,CCT3,AKR1C4,NOTCH1,NRP1,SORL1,CNN2,SUSD2,AKAP12,MAP7,FCGRT,GSTM5,SIN3B,TTLL4,HYOU1,FKBP1A,ATAT1,GPC4,RCOR2,MEOX2,TMEM259,THBS3,H2AFZ,SF3B3,TIGD5,ENAH,RPUSD3,CES1,JUN,CCL8,COL22A1,CD24,MYO1D,EGFL6,AHNAK2,PLXNA1,RBBP9,CD209,SLC25A13,CEP164,MYOM2,EGR1,TRIM28,DAAM1,BHLHE22,ARHGAP4,SLIT2,RELN,AXL,YIF1B,EMC1,GABRE,RBM42,BRINP2,SBF1,BMF,CILP,PTGS2,AOX1,CHD7,ZFYVE19,TM4SF1,SPNS1,TFF3,FARP1,UNC5B,MAP1B,TMEM147,ZNF91,DHTKD1,COMT,CYP4X1,NMNAT2,RET,MFSD3,PHACTR3,FUCA1,TRIOBP,GSDMB,USP36,SLC4A7,ALAD,TPSAB1/TPSB2,UBXN11,FLCN,SORD,LRRC41,RAP1GAP,N6AMT1,FRYL,SCRIB,CLCN7,AMY1C (includes others),SFRP2,ATF5,SLC4A11,TBCB,PTPRF,THBS1,DKK3,KIAA0040,ARHGEF35,SMO,CFB,ASAP3,NCL,CHEK2,RHBDD3,ZFP42,EMILIN1,TPST2,PCOLCE2,LRRK2,RPS21,CCDC85A,LOC401052,ANO2,SYBU,COL1A1,EBF1,PLEKHH1,FAM46A,CPZ,C6,KDR,XK,HCAR3,CSTA,HLA-DOA,SVEP1,PAPLN,ANKRD35,ANKRD20A4 (includes others),ASCC2,SPI1,CLIP1,FADS3,NSF,GNA15,NUP93,CTSH,KEAP1,KIF1A,RAB38,MCOLN3,LUM,KANK3,CEP170B,MGP,DLG4,KAT2A,SLCO2B1,ALDOC,TSHZ2,TM6SF1,SELE,FAM189B,DPT,MTSS1,MFAP5,TNFRSF10B,LAMC3,IFNAR2,TFPI2,HAX1,SHROOM4,WDR81,HSPA8,EVPL,CTSA,MN1,BTG2,SAMD4A,PTPRA,TRAPPC5,ZDHHC4,NME1,FGF2,ZNF205,C9orf24,SEMA6A,GDF15,CDK4,CTHRC1,CKAP4,ZBTB9,TECR,HS3ST3A1,SDHAF1,TGM2,ARFGAP1,HCAR2,RAD21,CYP51A1,FCGR3A/FCGR3B,G3BP2,FCER2,MAPKAP1,SPRY1,MLF2,MRPS25,GRN,FAM178B,ARHGEF5,LDLR,NTRK3,FLNC,ATP1A2,TAGLN,TAF1C,MAP3K8,TP53BP1,AARS2,TTYH3,ABCC3,BMP6,KTN1,ABCB6,FOXRED1,SLC38A10,AMDHD2,PTTG1,RTN1,HSPA1A/HSPA1B,ACO2,ABCG1,BIN1,MYC,TGFBR2,GPR4,TMEM8B,CXCL14,ZNF598,GYPE,FAR2,CHTF18,RPAP1,LRBA,FMO2,RILPL1,CLIP2,VEGFC,THRA,ANO1,CYB561,KLF4,DCHS1,GZMH,TRIM39,ORM1,MATN2,DUSP1,BUD31,APCDD1,LIMA1,IGFBP3,SORCS2,THAP7,AGAP3,ESR1,S100P,POLR3F,RUNX1,SPIRE2,SRPX,SF3B5,MECR,DENND4B,DCAF4,ABCF1,NUDT2,NEURL4,HNRNPK,SLC2A3,IRAK1,RPL14,MSRB3,SHC1,CCDC107,HLA-DRB1,AHNAK,TIMP1,SAA1,MEX3B,LOC102724428/SIK1,HES4,TOX2,VARS,CIZ1,GJA4,RBPMS,VCAM1,C4BPB,CTAGE9 (includes others),APBB1IP,SLC12A2,TUBG1,PGAP2,GNAI1,DLEU1,GATSL3,NUP210L,ATIC,SH3PXD2A,CXCL16,CLGN,TACC2,PHF19,CDC34,GAPVD1,PNPLA6,ZNF404,COQ9,NNAT,KCNK15,ITSN1,TRAP1,HRAS,CDKN2C,PCDH7,NCSTN,RAPH1,GRWD1,HOXA9,SATB2,MFAP2,NCOA7,PEX16,CLCNKA,NPTX2,SLC16A2,ANK2,VEGFD,IRS2,ALPK1,PKIA,EYA2,PEX6,PCSK5,RRBP1,TUBB2A,THY1,MMP2,TNK2,CRABP1,SERINC2,SRGAP3,TIMP4,CCND2,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,MS4A7,MAP2K3,MAPK7,ZER1,SFRP1,AIDA,CYR61,IFIT2,PDGFD,MYEOV,BOD1,DHRS4,SPTBN1,HIST1H1C,EMILIN2,PSMB10,TNFSF10,KAZN,FOLR2,PFKL,IDH1,UCHL1,EFNB2,ID1,MTOR,TARS2,SRGAP1,SLC2A6,DAP3,PRKCE,TPO,PCBP2,COL18A1,PTPRT,SF3A2,PTK7,DNAH6,MYCN,GSTM1,VPS18,ANGPT1,TWNK,TYROBP,MGMT,DPAGT1,CYP1B1,B4GALT2,F11R,RHPN2,COL5A3,CLDN5,FAM86C1,S100A9,CNN1,SPRY2,S1PR1,ALS2CL,CBX4,SYN2,C16orf89,CYP2C8,PHLDA1,SERPINI1,CLTB,SPHK2,CXCL12,LIPE,TPM1,COBL,MTCH2,CEL,CYP26B1,TNIP1,ITGA11,ASXL2,TMEM156,KPNA2,LTBR,TRIM5,PDK4,CSF3R,IGFBP6,AXIN2,TMIE,SPP1,MACROD1,PCSK7,LMNA,SNRK,FOXC1,DPP9,GSR,PPP2R1A,ERCC1,C9orf9,PKD1,CORO1B,SLC22A5,ACOT4,LSM7,PLEKHH3,AK2,THSD7B,RNPEP,AOC3,ADAMTS7,NFIX,ERN1,CHPF,PCMT1,PKM,ABL1,PPP1CB,TNFAIP3,SMPD1,ITGA10,HIF1A,PRKCSH,EPHB6,SOX17,TMEM119,ADSL,PCK2,CSPG4,FLNA,SRGN,KIT,ARHGEF2,S100A8,NR2F6,CTDNEP1,PTGER4,TMEM132B,SNAPC4,CXCR4,COPS7A,CPED1,SMAD7,CSF1R,NDUFA13,TRMT61A,LPAR1,LRP1B,ZNF585A,ELK1,EPB41L2,DSG2,MMP9	650	
Cellular Growth and Proliferation, Tissue Development	proliferation	proliferation of connective tissue cells	1.47E-09	 	0.768	 	-1.336	CBX7,CTGF,BMP4,ITSN1,TYRO3,HRAS,CDKN2C,NCSTN,IL6,SGPL1,CCND3,RARA,SMARCB1,P3H1,TSC2,LUM,CAV1,ATF4,TXN,WNT5B,NAB1,NDRG1,TNFRSF10B,DKC1,HBEGF,MMP2,JUNB,TNK2,MN1,CCND2,NPR3,CTSB,MAP2K3,ITGA1,SFRP1,CYR61,PDGFD,NOTCH1,FTH1,PHLPP1,ADM,AKAP12,FYN,LEPR,FGF2,CDK4,ADIPOQ,TNFSF10,CTHRC1,VCAN,IDH1,EFNB2,KLF9,B4GALT7,JUN,GADD45A,CCL2,IL34,TNMD,HGS,PLAT,MYCN,PTPRK,CSK,GRN,FOS,TF,S100A9,NTRK3,SERPINH1,SPRY2,PTGS2,BMP6,LIG1,SOCS3,TFG,PTTG1,HSPA1A/HSPA1B,SPHK2,CXCL12,TPM1,SDC4,MYC,TGFBR2,CTSD,IKBKG,PLCE1,RHOB,NUPR1,RET,ELN,IGFBP6,CXCL8,NOX4,MIF,APLNR,SPP1,FST,ATF3,LMNA,THRA,FOXC1,KLF4,INHBB,RASD1,SLC3A2,FOSB,STC1,BCL2L1,CCNG2,TLN2,DUSP1,PRKCD,LIMA1,IGFBP3,IDO1,GNL3,RCE1,ESR1,TXNRD2,VHL,TNFAIP8,RUNX1,SULF1,IGFBP4,LOX,LEP,PA2G4,BMP2,TPR,ABL1,SMPD1,HIF1A,NGF,CDKN2B,ETV6,PTPRF,TNFRSF12A,HDGF,HMOX1,TMEM119,AEBP1,HINT1,NFKBIA,CCL13,EDN1,TIMP1,DKK3,KCNMA1,SAA1,SMO,ERBB2,RNF144B,SULF2,MAPKAPK2,AGT,SRC,PARP10,SMAD6,SMAD7,EMD,PLAUR,SERTAD1,CSF1R,PSME3,ATIC,COL1A1,CAPNS1,LPAR1,VAV3,EDNRA,SPARC,DNM1L,DSG2,MMP9	175	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of phagocytes	1.75E-09	 	-1.221	bias	-3.403	RARRES2,CAMK1,APOB,LAMTOR2,CD36,CD4,HSPA1A/HSPA1B,ELANE,CTSG,CXCL12,IL6,GPC3,TGFBR2,RHOB,CAV1,RASGRP2,ETS1,FERMT3,PTX3,CXCL8,MIF,CMKLR1,SELE,ATG7,SPP1,COCH,FLOT1,MMP2,ITGAM,PIP5K1C,RTN4,CD14,IDO1,MAP2K3,MAPK7,SFRP1,MDK,CYR61,NOTCH1,CNN2,APOE,ADAM17,LEP,PLGRKT,ADIPOQ,IRF3,CCL3,GLRX,LYZ,NFKBIA,EDN1,CCL2,CCL3L3,THBS1,S100A8,HCAR2,FCGR3A/FCGR3B,AGT,FCER2,CCR1,VCAM1,C5AR1,NLRP3,UCP2,MMP28,CD69,ST3GAL6,F13A1,SLIT2,CSF1R,CYP1B1,RCAN1,LY96,VAV3,CAT,LSP1,LYN,S1PR1,MAP3K8,KDR,CXCL2,ST3GAL4,MMP9	83	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of leukocytes	1.86E-09	 	-1.559	 	-3.902	APOB,CAMK1,CTSG,ELANE,IL6,SGPL1,CAV1,TXN,ETS1,SELE,CMKLR1,ATG7,COCH,FLOT1,THY1,MMP2,NINJ1,CARD9,PIP5K1C,RTN4,MAP2K3,SFRP1,MAPK7,CYR61,NOTCH1,CNN2,APOE,ADAM17,GDF15,ADIPOQ,LYZ,JUN,CCL2,CCL3L3,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,C5AR1,CD69,EGR1,HDC,SLIT2,CYP1B1,FOS,LY96,SWAP70,LSP1,PELI1,S1PR1,LYN,MAP3K8,ST3GAL4,RARRES2,LAMTOR2,CD36,CD4,HSPA1A/HSPA1B,CXCL12,FCER1A,GPC3,TGFBR2,RHOB,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SPP1,ORMDL3,TPSAB1/TPSB2,ITGAM,CD14,IDO1,MDK,AOC3,LEP,PLGRKT,HIF1A,IRF3,CCL3,GLRX,HMOX1,NFKBIA,EDN1,THBS1,S100A8,AGT,VCAM1,NLRP3,MMP28,CXCR4,ST3GAL6,LRRK2,F13A1,CSF1R,RCAN1,CXCL16,VAV3,CAT,CXCL2,KDR,MMP9	104	
Cellular Function and Maintenance	engulfment	engulfment of tumor cell lines	1.94E-09	Increased	2.874	bias	0.359	PFN1,CD36,CXCL12,RGCC,IL6,SPI1,CLIP1,NKAP,MYC,ETS2,CAV1,KLF2,MARCO,PTX3,SHARPIN,HBEGF,HAX1,SRSF3,ITGAM,ASGR1,PRKCD,FZD5,APOE,ATP6V1D,RALA,TNFSF10,LRRC29,SF3B3,ATP6AP1,ASB1,TGM2,HMOX1,DAB2,NAA60,PRKCE,ERBB2,NCL,CD209,AP2M1,CSK,RPS21,AXL,BTK,ATP6V1E1,RRAS2,ATP6V1F,PLEKHG6,WAS,PELI1,LYN,EPB41L2,P2RX7,ATP6V1B2	53	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	rheumatoid arthritis	rheumatoid arthritis	1.97E-09	 	-0.416	 	-0.720	HLA-DOA,CACNA1H,CTSG,C1QA,CLSTN2,IL6,EEF1G,SKIV2L,IP6K3,ECHDC1,CERS6,PTGIS,TNFRSF21,RBM38,SELE,COMP,TNFRSF10B,IFNAR2,TMEM127,HSPA8,HLA-DRB4,VARS2,CTSB,TFRC,CD86,FTH1,APOE,GADD45B,COL4A5,FGF2,ADIPOQ,ZBTB9,C1R,CCL2,IL17D,FCGR3A/FCGR3B,CCR1,TJP1,CD69,SPATS2L,TK2,GRN,FOS,HP,NR4A2,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,PADI4,CARD8,CXCL14,EEF1E1,CXCL8,PPP1R11,FOSB,H3F3A/H3F3B,DUSP1,SLC7A2,NAGLU,FZD5,MDK,C2,RBP4,IGFBP4,FRZB,TPGS2,CCL3,HLA-G,HLA-DRB1,TIMP1,SAA1,VARS,SRC,VCAM1,PLAUR,HCG9,ATIC,CXCL16,PHF19,SMG7,CXCL2,MAP4K4,COX15,PRUNE2,BMP4,ELANE,HSD17B8,NR4A3,TXN,MCL1,PPIL6,CALCRL,MMP2,AQP9,CD68,IL10RA,MS4A7,GLUL,ALDOA,ALAS2,ANG,COL3A1,ADM,SORL1,MME,FCGRT,SQLE,SCAP,ZFP36,ATAT1,FKBP1A,ST6GALNAC4,TNFSF10,GPC4,LYZ,MTOR,CCL3L1,CCL8,CST3,SLC19A1,CD24,LBP,FUK,RPS24,STK19,C5AR1,TRIM28,CINP,ACLY,BRMS1,POLD1,PLA2G2A,GABRE,F11R,GLIPR2,S100A9,CELF2,S1PR1,PTGS2,VPS52,TFG,CD4,CD36,CXCL12,IL17RC,SDC4,NRSN2,G0S2,CAMK2D,UQCC2,ARL16,GCA,WDR46,ACTA1,PHACTR3,CSF3R,MIF,SPP1,HNMT,DNASE2,CYYR1,LMO4,GSR,C1QTNF6,ASIC1,CCL18,ADAMTS7,PRDX5,TNFAIP3,SLC7A1,SIL1,NGF,RAMP2,NELFE,EVC,HMOX1,CCL13,NFKBIA,THBS1,CFB,S100A8,ALPL,CHEK2,PTGER4,PRNP,ADRB2,MIPEP,CXCR4,LRRK2,VSIG4,ENO1,FAF1,DIP2C,DYM,LRP1B,MMP9	199	
Cancer, Organismal Injury and Abnormalities	head and neck cancer	head and neck cancer	2.16E-09	 	-0.658	 	0.158	CBX7,PCLO,AXIN1,NOMO1 (includes others),IL6,POLRMT,POR,IDUA,UPK3BL,CCND3,ATG9A,EIF3B,AJUBA,SMARCB1,TSC2,DEFB132,PLXNB2,WASH3P,ETS1,COMP,KIAA0513,mir-21,GNA11,COL15A1,DDX3X,SYNM,SPON1,GPC6,ATN1,MTSS1L,MECOM,EMP3,POLR1E,SPATS2L,PDZD2,GPAM,AFF3,KIF7,HNRNPH1,LYN,PROCR,SOX9,MXRA5,SOCS3,FAM136A,ARSD,AKR1C3,ANKMY1,ZFPM1,AP1B1,GPC3,CEP104,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,CPNE1,TEK,CXCL8,ADAMTS1,MAPK8IP2,RIMS4,LZTR1,ERCC2,UBL4A,KANK1,BCL2L1,H3F3A/H3F3B,ZNF296,SLC7A2,C19orf54,BAP1,NAGLU,C17orf97,VHL,UBE2I,SULF1,FEM1A,ZP3,FLRT1,ZNF252P,INPPL1,GIMAP6,DHCR7,EDN1,GTPBP2,ERBB2,THBS4,SRC,NDUFV1,PLAUR,PYGB,SAA2,FRMD4A,ORAOV1,POLR3B,COL11A1,ING1,CXCL2,FCGBP,PRUNE2,KCND2,DDX11,CTGF,BMP4,TYRO3,MST1,GYG2,POMC,HOMER3,EIF6,SGPL1,ITGA3,PRG4,MTUS1,PNKD,TESK1,MCL1,POLR2I,PPIL6,CAPN5,PIK3C2B,EFL1,TMEM37,NAB1,PLEC,HMGA1,CHI3L2,THBD,FAM86B1,ACAD11,CORO7/CORO7-PAM16,MAP3K12,CCZ1/CCZ1B,CCT3,AKR1C4,NOTCH1,NRP1,SORL1,CNN2,SUSD2,AKAP12,MAP7,FCGRT,GSTM5,SIN3B,TTLL4,FKBP1A,ATAT1,GPC4,RCOR2,MEOX2,TMEM259,THBS3,SF3B3,TIGD5,ENAH,RPUSD3,CES1,JUN,CCL8,CD24,EGFL6,AHNAK2,RBBP9,CEP164,MYOM2,EGR1,TRIM28,DAAM1,BHLHE22,ARHGAP4,SLIT2,RELN,AXL,YIF1B,GABRE,RBM42,BRINP2,BMF,CILP,PTGS2,CHD7,ZFYVE19,TM4SF1,TFF3,FARP1,UNC5B,MAP1B,ZNF91,COMT,NMNAT2,RET,PHACTR3,MFSD3,FUCA1,TRIOBP,GSDMB,USP36,SLC4A7,ALAD,TPSAB1/TPSB2,UBXN11,FLCN,SORD,LRRC41,RAP1GAP,N6AMT1,FRYL,SCRIB,AMY1C (includes others),SFRP2,ATF5,SLC4A11,TBCB,PTPRF,THBS1,KIAA0040,ARHGEF35,SMO,CFB,ASAP3,NCL,CHEK2,RHBDD3,EMILIN1,TPST2,PCOLCE2,LRRK2,RPS21,CCDC85A,LOC401052,COL1A1,EBF1,PLEKHH1,FAM46A,CPZ,KDR,XK,CSTA,HCAR3,HLA-DOA,ANKRD35,PAPLN,SVEP1,ANKRD20A4 (includes others),ASCC2,SPI1,CLIP1,FADS3,NSF,GNA15,NUP93,CTSH,KEAP1,RAB38,KIF1A,CEP170B,KANK3,MGP,DLG4,KAT2A,SLCO2B1,TSHZ2,TM6SF1,FAM189B,DPT,MTSS1,MFAP5,TNFRSF10B,LAMC3,IFNAR2,HAX1,SHROOM4,WDR81,EVPL,MN1,CTSA,BTG2,SAMD4A,PTPRA,TRAPPC5,NME1,FGF2,ZNF205,C9orf24,SEMA6A,GDF15,CDK4,CTHRC1,ZBTB9,CKAP4,TECR,HS3ST3A1,SDHAF1,TGM2,ARFGAP1,HCAR2,RAD21,CYP51A1,FCGR3A/FCGR3B,G3BP2,FCER2,MAPKAP1,SPRY1,MLF2,MRPS25,GRN,FAM178B,ARHGEF5,FLNC,ATP1A2,TAGLN,TAF1C,MAP3K8,AARS2,TP53BP1,TTYH3,ABCC3,ABCB6,FOXRED1,AMDHD2,SLC38A10,PTTG1,RTN1,HSPA1A/HSPA1B,ACO2,ABCG1,MYC,TGFBR2,GPR4,TMEM8B,CXCL14,ZNF598,GYPE,CHTF18,LRBA,FMO2,RILPL1,CLIP2,VEGFC,THRA,ANO1,CYB561,DCHS1,KLF4,GZMH,TRIM39,ORM1,MATN2,DUSP1,APCDD1,LIMA1,SORCS2,THAP7,IGFBP3,ESR1,S100P,POLR3F,RUNX1,SPIRE2,SRPX,SF3B5,MECR,DENND4B,ABCF1,NUDT2,NEURL4,HNRNPK,SLC2A3,IRAK1,RPL14,SHC1,CCDC107,HLA-DRB1,AHNAK,TIMP1,SAA1,MEX3B,LOC102724428/SIK1,HES4,TOX2,VARS,GJA4,RBPMS,VCAM1,C4BPB,CTAGE9 (includes others),APBB1IP,SLC12A2,TUBG1,PGAP2,GNAI1,DLEU1,GATSL3,ATIC,SH3PXD2A,CXCL16,CLGN,TACC2,PHF19,CDC34,GAPVD1,ZNF404,PNPLA6,COQ9,NNAT,KCNK15,TRAP1,HRAS,CDKN2C,PCDH7,NCSTN,GRWD1,HOXA9,SATB2,MFAP2,NCOA7,PEX16,CLCNKA,NPTX2,SLC16A2,ANK2,VEGFD,IRS2,PKIA,EYA2,PEX6,PCSK5,RRBP1,TUBB2A,THY1,MMP2,CRABP1,SERINC2,SRGAP3,TIMP4,CCND2,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,MAP2K3,MAPK7,ZER1,SFRP1,AIDA,CYR61,IFIT2,PDGFD,MYEOV,BOD1,DHRS4,SPTBN1,HIST1H1C,EMILIN2,PSMB10,TNFSF10,FOLR2,KAZN,PFKL,IDH1,UCHL1,EFNB2,ID1,MTOR,SRGAP1,SLC2A6,DAP3,PRKCE,TPO,COL18A1,PTPRT,SF3A2,PTK7,MYCN,GSTM1,VPS18,ANGPT1,TWNK,TYROBP,MGMT,DPAGT1,CYP1B1,B4GALT2,F11R,RHPN2,COL5A3,CLDN5,FAM86C1,S100A9,CNN1,SPRY2,S1PR1,ALS2CL,CBX4,SYN2,C16orf89,CYP2C8,PHLDA1,SERPINI1,CLTB,SPHK2,CXCL12,LIPE,TPM1,MTCH2,CEL,CYP26B1,TNIP1,ITGA11,ASXL2,LTBR,PDK4,CSF3R,IGFBP6,AXIN2,TMIE,SPP1,MACROD1,PCSK7,LMNA,SNRK,FOXC1,DPP9,GSR,PPP2R1A,C9orf9,ERCC1,CORO1B,PKD1,SLC22A5,ACOT4,LSM7,PLEKHH3,AK2,THSD7B,RNPEP,AOC3,ADAMTS7,NFIX,ERN1,CHPF,PCMT1,PKM,ABL1,PPP1CB,TNFAIP3,SMPD1,ITGA10,HIF1A,PRKCSH,EPHB6,SOX17,TMEM119,ADSL,PCK2,CSPG4,SRGN,KIT,ARHGEF2,S100A8,NR2F6,CTDNEP1,PTGER4,TMEM132B,SNAPC4,CXCR4,COPS7A,SMAD7,CSF1R,NDUFA13,TRMT61A,LPAR1,LRP1B,ZNF585A,ELK1,EPB41L2,DSG2,MMP9	583	
Cardiovascular Disease	occlusion	occlusion of artery	2.20E-09	 	0.597	 	-0.236	HCAR3,PLIN1,ACAT2,APOB,IL6,GSS,ATP2A2,SLC9A1,GAA,CAV1,CERS6,SELE,TUBB2A,MMP2,SCNN1D,JUNB,THBD,NPR3,VKORC1,RTN4,LRP8,PLTP,SAMD4A,APOE,ZFP36,GDF15,CCDC167,ADIPOQ,TNFSF10,FKBP1A,LRRC20,MTOR,CES1,JUN,CCL2,CCL3L3,SORBS1,CST3,PDE3B,PLIN2,LIPG,COL18A1,ADORA1,ABCC9,HCAR2,ALDH5A1,PLAT,CCR1,SIGMAR1,FMO3,MECOM,IMPDH2,EGR1,RNF157,DGAT2,GABRE,PLA2G2A,FOS,HP,MTHFD1L,SUPV3L1,LAMP2,LDLR,CBS/CBSL,S100A9,S1PR1,PROCR,PTGS2,MSRA,SGCD,RGS1,SOCS3,PFN1,CD36,PLA2G15,KLF6,CXCL12,LIPE,ABCG1,ARG2,SDC4,CD163,TGFBR2,NNMT,CYP26B1,CEL,IKBKG,COMT,PLA2G5,TUBA1C,GCLM,BIRC3,KLF2,PTX3,ELN,KCNJ8,MIF,SPP1,SGCG,KLF4,FOSB,ITGAM,ADRA2A,MATN2,ASIC1,CD14,ESR1,ADAMTS7,LEP,ERN1,TNFAIP3,QPRT,HMOX1,SHC1,CD55,NFKBIA,EDN1,F8,TIMP1,THBS1,SAA1,S100A8,PTGER4,ADRB2,AGT,SNAPC4,VCAM1,PARVA,COL5A2,CD59,CYP27A1,ATP2C1,TUBG1,PLAUR,F13A1,FRMD4A,CXCL16,PBX3,VAV3,ASTN2,APOC1,ACAT1,GBE1,KDR,CXCL2,MMP9	146	
Cell-To-Cell Signaling and Interaction, Cellular Movement	recruitment	recruitment of blood cells	2.42E-09	 	-1.623	bias	-3.991	APOB,CAMK1,CTSG,ELANE,IL6,SGPL1,CAV1,TXN,ETS1,CMKLR1,SELE,ATG7,COCH,FLOT1,THY1,MMP2,NINJ1,CARD9,PIP5K1C,RTN4,MAP2K3,SFRP1,MAPK7,CYR61,NOTCH1,CNN2,APOE,ADAM17,GDF15,ADIPOQ,LYZ,JUN,CCL2,CCL3L3,HCAR2,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,C5AR1,ANGPT1,CD69,EGR1,HDC,SLIT2,CYP1B1,FOS,LY96,SWAP70,LSP1,PELI1,LYN,S1PR1,MAP3K8,ST3GAL4,RARRES2,LAMTOR2,CD36,CD4,HSPA1A/HSPA1B,CXCL12,FCER1A,GPC3,TGFBR2,RHOB,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SPP1,ORMDL3,TPSAB1/TPSB2,ITGAM,CD14,IDO1,MDK,AOC3,LEP,PLGRKT,HIF1A,IRF3,CCL3,GLRX,HMOX1,NFKBIA,EDN1,THBS1,S100A8,AGT,VCAM1,NLRP3,MMP28,CXCR4,ST3GAL6,LRRK2,F13A1,CSF1R,RCAN1,CXCL16,VAV3,CAT,CXCL2,KDR,MMP9	105	
Cellular Movement	cell movement	cell movement of tumor cells	2.52E-09	 	0.433	 	-1.312	CTGF,PTTG1,CXCL12,HRAS,IL6,ITGA3,RHOB,LUM,CAV1,VEGFD,SIAH2,IRS2,RET,CSF3R,CXCL8,MIF,SELE,SPP1,HBEGF,MMP2,KLF4,CDH2,DUSP1,CTSB,ALCAM,SFRP1,PDGFD,VHL,MAP2K5,S100P,NRP1,SH3BP4,SFRP2,LEP,EMILIN2,ADIPOQ,CCL3,VCAN,RAB5A,NFKBIA,CCL2,THBS1,CSF2RA,MCAM,PRKCE,COL18A1,SOX7,SRC,VCAM1,PAK4,CXCR4,PLAUR,SLIT2,CSF1R,SPRY2,LSP1,LYN,SPARC,PTGS2,KDR,NEDD9,DSG2,MMP9,TM4SF1	64	
Cardiovascular Disease	vaso-occlusion	vaso-occlusion	2.62E-09	 	0.480	 	-0.333	HCAR3,PLIN1,ACAT2,APOB,IL6,GSS,ATP2A2,SLC9A1,SP110,GAA,CAV1,CERS6,SELE,TUBB2A,MMP2,SCNN1D,JUNB,THBD,NPR3,VKORC1,RTN4,LRP8,PLTP,SAMD4A,APOE,ZFP36,GDF15,CCDC167,ADIPOQ,TNFSF10,FKBP1A,LRRC20,MTOR,CES1,JUN,CCL2,CCL3L3,SORBS1,CST3,PDE3B,PLIN2,LIPG,COL18A1,ADORA1,ABCC9,HCAR2,ALDH5A1,PLAT,CCR1,SIGMAR1,FMO3,MECOM,IMPDH2,EGR1,RNF157,DGAT2,GABRE,PLA2G2A,FOS,HP,MTHFD1L,SUPV3L1,LAMP2,LDLR,CBS/CBSL,S100A9,S1PR1,PROCR,PTGS2,MSRA,SGCD,RGS1,SOCS3,PFN1,CD36,PLA2G15,KLF6,CXCL12,LIPE,ABCG1,ARG2,SDC4,CD163,TGFBR2,NNMT,CYP26B1,CEL,IKBKG,COMT,PLA2G5,TUBA1C,GCLM,BIRC3,KLF2,PTX3,ELN,KCNJ8,MIF,SPP1,SGCG,KLF4,FOSB,ITGAM,ADRA2A,MATN2,ASIC1,CD14,ESR1,ADAMTS7,LEP,ERN1,TNFAIP3,QPRT,HMOX1,SHC1,CD55,NFKBIA,EDN1,F8,TIMP1,THBS1,SAA1,S100A8,PTGER4,ADRB2,AGT,SNAPC4,VCAM1,PARVA,COL5A2,CD59,CYP27A1,ATP2C1,TUBG1,PLAUR,F13A1,FRMD4A,CXCL16,PBX3,VAV3,ASTN2,APOC1,ACAT1,GBE1,KDR,CXCL2,MMP9	147	
Cardiovascular Disease	atherosclerosis	atherosclerosis	2.81E-09	 	0.726	 	-0.055	HCAR3,PLIN1,ACAT2,APOB,IL6,GSS,ATP2A2,SLC9A1,GAA,CAV1,CERS6,SELE,TUBB2A,MMP2,SCNN1D,JUNB,THBD,NPR3,VKORC1,RTN4,LRP8,PLTP,SAMD4A,APOE,ZFP36,GDF15,CCDC167,ADIPOQ,TNFSF10,FKBP1A,LRRC20,MTOR,CES1,JUN,CCL2,CCL3L3,SORBS1,PDE3B,CST3,PLIN2,LIPG,COL18A1,ADORA1,ABCC9,HCAR2,ALDH5A1,PLAT,CCR1,SIGMAR1,FMO3,MECOM,IMPDH2,EGR1,RNF157,DGAT2,GABRE,PLA2G2A,FOS,HP,MTHFD1L,SUPV3L1,LAMP2,LDLR,CBS/CBSL,S100A9,S1PR1,MSRA,PTGS2,SGCD,RGS1,SOCS3,PFN1,CD36,PLA2G15,KLF6,LIPE,ABCG1,ARG2,SDC4,CD163,TGFBR2,NNMT,CYP26B1,CEL,IKBKG,COMT,PLA2G5,TUBA1C,GCLM,BIRC3,KLF2,PTX3,ELN,KCNJ8,MIF,SPP1,SGCG,KLF4,FOSB,ITGAM,ADRA2A,MATN2,ASIC1,CD14,ESR1,ADAMTS7,LEP,ERN1,TNFAIP3,QPRT,HMOX1,SHC1,CD55,NFKBIA,EDN1,TIMP1,THBS1,SAA1,S100A8,ADRB2,AGT,SNAPC4,VCAM1,PARVA,COL5A2,CD59,CYP27A1,ATP2C1,TUBG1,PLAUR,F13A1,FRMD4A,CXCL16,PBX3,ASTN2,APOC1,ACAT1,GBE1,KDR,CXCL2,MMP9	141	
Cardiovascular Disease	occlusion	occlusion of blood vessel	3.65E-09	 	0.597	 	-0.179	HCAR3,PLIN1,ACAT2,APOB,IL6,GSS,ATP2A2,SLC9A1,SP110,GAA,CAV1,CERS6,SELE,TUBB2A,MMP2,SCNN1D,JUNB,THBD,NPR3,VKORC1,RTN4,LRP8,PLTP,SAMD4A,APOE,ZFP36,GDF15,CCDC167,ADIPOQ,TNFSF10,FKBP1A,LRRC20,MTOR,CES1,JUN,CCL2,CCL3L3,SORBS1,CST3,PDE3B,PLIN2,LIPG,COL18A1,ADORA1,ABCC9,HCAR2,ALDH5A1,PLAT,CCR1,SIGMAR1,FMO3,MECOM,IMPDH2,EGR1,RNF157,DGAT2,GABRE,PLA2G2A,FOS,HP,MTHFD1L,SUPV3L1,LAMP2,LDLR,CBS/CBSL,S100A9,S1PR1,PROCR,PTGS2,MSRA,SGCD,RGS1,SOCS3,PFN1,CD36,PLA2G15,KLF6,CXCL12,LIPE,ABCG1,ARG2,SDC4,CD163,TGFBR2,NNMT,CYP26B1,CEL,IKBKG,COMT,PLA2G5,TUBA1C,GCLM,BIRC3,KLF2,PTX3,ELN,KCNJ8,MIF,SPP1,SGCG,KLF4,FOSB,ITGAM,ADRA2A,MATN2,ASIC1,CD14,ESR1,ADAMTS7,LEP,ERN1,TNFAIP3,QPRT,HMOX1,SHC1,CD55,NFKBIA,EDN1,F8,TIMP1,THBS1,SAA1,S100A8,PTGER4,ADRB2,AGT,SNAPC4,VCAM1,PARVA,COL5A2,CD59,CYP27A1,ATP2C1,TUBG1,PLAUR,F13A1,FRMD4A,CXCL16,PBX3,VAV3,ASTN2,APOC1,ACAT1,GBE1,KDR,CXCL2,MMP9	147	
Cellular Movement	migration	migration of cancer cells	4.33E-09	 	0.550	 	-1.235	CTGF,PTTG1,CXCL12,HRAS,IL6,ITGA3,RHOB,CSE1L,LUM,CAV1,VEGFD,SIAH2,IRS2,RET,AHCY,CSF3R,CXCL8,MIF,SELE,SPP1,HBEGF,MMP2,KLF4,CDH2,DUSP1,CTSB,ALCAM,SFRP1,PDGFD,VHL,MAP2K5,S100P,NRP1,SH3BP4,SFRP2,LEP,EMILIN2,ADIPOQ,CCL3,VCAN,RAB5A,NFKBIA,CCL2,THBS1,CSF2RA,MCAM,PRKCE,COL18A1,SOX7,SRC,VCAM1,PAK4,CXCR4,PLAUR,SLIT2,CSF1R,SPRY2,LSP1,LYN,SPARC,PTGS2,KDR,NEDD9,DSG2,MMP9,TM4SF1	66	
Cell Death and Survival	cell viability	cell viability of tumor cell lines	4.95E-09	Increased	3.619	bias	-0.689	WBSCR22,RRM2B,IL6,PPP1R3F,IP6K3,CYBA,MCOLN3,KIF1A,TSC2,SMARCB1,CAV1,PPP1R1B,TNFRSF10B,NPY5R,AEN,BTG2,PSMA4,ACACA,SQSTM1,PTPRA,mir-21,FTH1,APOE,FGF2,GDF15,CEBPD,CTDSPL,DUSP22,SYNM,DIABLO,TGM2,DUSP5,CCL2,SWI5,PIK3R2,TRIM29,RAD21,LIG3,MECOM,IGF2R,NTRK3,LYN,TP53BP1,PIN1,ABCC3,ID4,ABCB6,LIG1,SOCS3,KLF6,PARP2,TRPM8,TYMP,HSPA5,MYC,TGFBR2,NUPR1,CXCL8,NOX4,ATF3,ADAMTS1,H6PD,AURKAIP1,VEGFC,PPP1R11,ERCC2,KLF4,FAAP20,BCL2L1,DUSP1,IGFBP3,CAPN2,MDK,DNAJB6,VHL,DPH5,UBE2I,TNFAIP8,SULF1,SFTPD,CARS,BMP2,ATF6,KIFC2,IRAK1,HLA-G,MCAM,ERBB2,ATP13A2,NDUFAF4,SRC,USMG5,PLAUR,BTK,RCAN1,CAT,ING1,ALKBH3,CXCL2,EIF3C,CTGF,SGK1,NCSTN,HRAS,RARA,ABCC1,IRS2,TXN,MCL1,BIRC7,CDKN1C,ATG7,GUCY1A3,FANCG,HBEGF,RPA1,HMGA1,IER3,TNK2,THBD,ROR1,LDOC1,DPH2,DOCK1,CDH2,VKORC1,MAPK7,NOTCH1,PHLPP1,NRP1,FYN,ADAM17,SCAP,ZFP36,CHCHD6,KAZN,TNFSF10,ASNS,VCAN,IDH1,MCOLN1,LYZ,MTOR,JUN,SLC19A1,CD24,PRKCE,PTPRT,PLAT,PRPH,GSTM1,MYCN,PTPRK,TRIM28,MGMT,AXL,DUSP14,LMO3,S100A9,SBF1,PPP1R16B,CDK20,CHFR,GPR180,PTGS2,PRPF19,PTPN23,ADRBK1,CXCL12,ZNF91,CEL,CAMK2D,PLCE1,GSK3B,GPC1,RET,BCKDK,PTPRE,SPP1,USP36,AGTRAP,DPP9,STC1,PPP2R1A,ITGAM,ERCC1,PRKCD,CCL18,MAP2K5,ANTXR1,PKM,ABL1,SLC7A1,HIF1A,NGF,PTPRF,PDCD4,HMOX1,CD55,HINT1,NFKBIA,FLNA,DUSP10,SMO,RPS6KB2,KIT,PSMA3,NEK7,MAPKAPK2,CUL9,CHEK2,PRNP,BEX2,CXCR4,RNF126,NDUFA13,THRSP,PRMT1,TRIM69,ENO1,COL1A1,PBX3,ELK1,KDR	224	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	necrosis	necrosis of tumor	5.21E-09	 	-1.526	 	-0.633	EIF3C,BMP4,SGK1,RAN,HRAS,SERPINA3,IL6,SPI1,EIF3B,CCND3,CSE1L,RARA,KEAP1,CAV1,TXN,HIPK2,MCL1,TNFRSF21,ETS1,BIRC7,CAPN6,ATG7,NDRG1,TNFRSF10B,MAD2L2,HBEGF,TIMP4,BSG,RTN4,CTSB,PSMA4,RPL6,EBNA1BP2,ITGA1,SFRP1,MAPK7,CYR61,PTPRA,NOTCH1,mir-21,PHLPP1,NRP1,ZFP36,DDIT3,FGF2,LEPR,GDF15,ADIPOQ,TNFSF10,SF3B3,DIABLO,TRIB1,MTOR,JUN,GADD45A,CD24,PRKCE,COL18A1,RPS24,MYCN,BRMS1,ACLY,FOS,NR4A2,MCM2,TF,SPRY2,PROCR,PIN1,PTGS2,BMP6,PHLDA1,SOCS3,HSPA1A/HSPA1B,CXCL12,TPM1,MYC,TGFBR2,RHOB,CARD8,GSK3B,LTBR,PUF60,BIRC3,TEK,CSF3R,CXCL8,MIF,PSMB5,NUP155,HSPA9,BTG1,POLR2H,VEGFC,PAWR,ERCC2,RPL9,STC1,BCL2L1,PRKCD,IGFBP3,VHL,MAP2K5,UBE2I,RUNX1,SFRP2,LEP,BMP2,ABL1,HIF1A,NGF,HMOX1,DHCR7,NFKBIA,TIMP1,KIT,PSMA3,ISCU,ERBB2,SEMA3B,PRNP,BEX2,VCAM1,CD59,SNRPB,CXCR4,LRRK2,PLAUR,RPS21,TNFRSF14,BTK,ENO1,LPAR1,CAT,EDNRA,SPARC,TSC22D1,KDR,MMP9,RPLP0	140	
Embryonic Development, Organismal Development	development	development of body trunk	5.63E-09	 	1.496	bias	-1.143	AXIN1,RRM2B,IL6,SLC35C1,SPI1,ATP2A2,ODC1,POR,IDUA,EGR2,GYS1,CCND3,CTSH,TSC2,MGP,CAV1,ATF4,NABP2,MYL3,CASQ2,AMHR2,ETS1,HEYL,SELE,STK36,PYGO2,DVL2,CDH5,ATMIN,CD86,ITGA1,TULP3,DEAF1,mir-21,APOE,NME1,FHL1,COL4A5,FGF2,CFC1/CFC1B,GNA11,GDF15,CEBPD,CDK4,ADIPOQ,TGM2,TIPARP,CCL2,SOS1,LY6E,GNG5,CYP51A1,HEY1,MECOM,SPRY1,ZNF521,MESP1,CDO1,IGF2R,ID3,MYO5A,FOS,HP,KIF7,ZFPM2,CBS/CBSL,NTRK3,GPBAR1,SOX9,NLE1,BMPER,SEMA3C,PIN1,BMP6,ID4,ADRA1A,LIG1,SOCS3,PTTG1,ABCA3,KLF6,ZFPM1,AP1B1,GPC3,BIN1,CEBPG,MYC,TGFBR2,ADGRF5,MAP2K2,CXCL14,NEDD4L,TEK,ELN,KCNJ8,NOX4,ATF3,PKP2,ADAMTS1,VEGFC,THRA,ERCC2,DCHS1,FOSB,BCL2L1,DUSP1,ALDH1A2,DNAJB6,MDK,MEGF8,ESR1,TXNRD2,VHL,RBP4,RUNX1,SULF1,LOX,SFTPD,ZP3,BMP2,CLUAP1,EMX2,HNRNPK,HDGF,CIAPIN1,SHC1,DHCR7,SH3PXD2B,EDN1,TIMP1,MKL2,ERBB2,AGT,GJA4,SLC20A1,SRC,VCAM1,DHRS3,SMAD6,ZPR1,PMP22,XYLT2,CAPNS1,RRAS2,CAT,SPARC,TSC22D1,COL11A1,DNM1L,CTGF,BMP4,TGFBR3,HRAS,CDKN2C,MST1,NCSTN,POMC,APRT,HOXA9,SGPL1,ITGA3,DMRT2,GAA,RARA,DNAJA3,IRS2,HEY2,CALCRL,CMKLR1,ATG7,NAB1,PCSK5,FANCG,PLEC,HBEGF,MMP2,THBD,S1PR3,CCND2,PIP5K1C,EPB42,STIP1,NPRL3,MAPK7,SFRP1,CYR61,NOTCH1,NRP1,COL3A1,ADM,AKAP12,SPTBN1,FYN,ADAM17,LEPR,SIN3B,FKBP1A,MEOX2,MYH11,VCAN,COL5A1,ID1,MTOR,JUN,ALDH1A3,CST3,PDE3B,STARD13,SOCS2,SLC19A1,LBP,NCKIPSD,PLOD3,PLAT,PTK7,CYP11A1,MYCN,CTSK,ADRM1,ANGPT1,TYROBP,EGR1,DAAM1,TMED2,SLIT2,YBX2,KRT8,TF,LIMS1,BMF,SPRY2,S1PR1,FKBP4,NR5A2,DBNL,DVL3,CBX4,TAZ,PTGS2,CHD7,FZD7,ADRBK1,CD4,PLA2G15,CLEC3B,LHCGR,CXCL12,TPM1,TAF10,CAMK2D,ALDH1A1,PLCE1,CRIP1,ITGA11,ASXL2,OSR1,GSK3B,LTBR,RET,FZD2,KLF2,ADRA1B,APLNR,SPP1,FST,SGCG,LMO4,EGR3,MAPK8IP3,FOXC1,PKN1,INHBB,PKD1,SLC22A5,RGN,CD14,AKR1B1,TMOD1,MAP2K5,LEP,NFIX,ERN1,FLRT2,PKM,ABL1,SMPD1,MYLK,HIF1A,NGF,AKIP1,RAMP2,CDKN2B,PTPRF,PDCD4,PRKCSH,SOX17,HMOX1,AEBP1,THBS1,FLNA,SMO,KIT,HSD11B2,SULF2,STK40,ACADM,PTGER4,ADRB2,RHBDD3,PAK4,EPAS1,CXCR4,AQP11,HYAL1,SMAD7,LRRK2,CSF1R,THRSP,ITPA,PBX3,EPHB3,EDNRA,KDR,CPEB1,DSG2,CARM1,MPV17,MMP9	328	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral squamous cell carcinoma	oral squamous cell carcinoma	5.77E-09	 	 	 	 	CSTA,BMP4,SERPINI1,CTGF,CXCL12,PCDH7,TPM1,GPC3,CYP26B1,ITGA11,CTSH,RAB38,NPTX2,CXCL14,MGP,TUBA1C,IGFBP6,CXCL8,DPT,MTSS1,MFAP5,TUBB2A,THBD,HAX1,MATN2,IGFBP3,PDGFD,SULF1,MAP7,EMILIN2,PKM,PPP1CB,TNFSF10,CTHRC1,ITGA10,COL15A1,SPON1,TGM2,CCL8,SRGN,EGFL6,ERBB2,GPC6,THBS4,SPRY1,TUBG1,DAAM1,DPAGT1,F11R,EBF1,LPAR1,CNN1,TAGLN,CILP,COL11A1,PTGS2,ING1,CXCL2,KDR,DSG2,TM4SF1	61	
Cell Death and Survival	necrosis	necrosis of vascular endothelial cells	5.88E-09	 	0.054	 	-0.055	ADM,LEP,ITSN1,DDIT3,FGF2,ERN1,CD36,SEMA6A,ADIPOQ,CXCL12,TNFSF10,ARG2,HSPA5,HMOX1,NR4A3,ALDH2,RGS5,THBS1,MCAM,CAV1,PRKCE,S100A8,GSK3B,SEMA3B,COL18A1,CXCL8,COMP,ATF3,SPP1,UCP2,ANGPT1,TNFRSF10B,MMP2,AXL,BCL2L1,CAT,HIF1AN,IGFBP3,MAPK7,KDR,MMP9,mir-21,RBP4	43	
Cellular Movement	cellular infiltration	cellular infiltration of blood cells	6.15E-09	 	-0.262	 	-0.993	CTGF,CTSG,ELANE,HRAS,IL6,RARA,CAV1,TNFRSF21,ETS1,CMKLR1,SELE,NDRG1,PLEC,MMP2,THBD,NINJ1,PPP1R15A,CTSB,CD86,ITGA1,PLTP,SFRP1,CYR61,ADM,APOE,ADAM17,NQO2,ADIPOQ,HYOU1,TNFSF10,TGM2,CES1,GBA,CCL2,CCL3L3,STIM1,LBP,PIK3R2,GJB2,IL11RA,PLAT,CCR1,CD276,UCP2,C5AR1,SLIT2,PLA2G4A,LDLR,S100A9,PELI1,FCER1G,PROCR,MAP3K8,PTGS2,SOCS3,TNFRSF4,ADRBK1,CD36,UNC5B,CXCL12,HARS,TGFBR2,RSPO3,IKBKG,PLA2G5,LTBR,PTX3,CXCL8,MIF,SPP1,STC1,EFS,ITGAM,DUSP1,PRKCD,IGFBP3,CD14,IDO1,MDK,CCL18,AKR1B1,ESR1,C2,TNFAIP8,LEP,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,CD55,NFKBIA,EDN1,TIMP1,THBS1,SAA1,DUSP10,MCAM,CFB,S100A8,ERBB2,MAPKAPK2,ADRB2,AGT,VCAM1,NLRP3,NQO1,PCOLCE2,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,CXCL16,VAV3,SPARC,C6,CXCL2,KDR,P2RX7,MMP9	121	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral cavity carcinoma	oral cavity carcinoma	6.43E-09	 	 	 	 	CSTA,BMP4,SERPINI1,CTGF,CXCL12,PCDH7,TPM1,IL6,GPC3,CYP26B1,ITGA11,CTSH,RAB38,NPTX2,CXCL14,MGP,TUBA1C,IGFBP6,CXCL8,DPT,MTSS1,MFAP5,TUBB2A,THBD,HAX1,MATN2,IGFBP3,PDGFD,SULF1,MAP7,EMILIN2,PKM,PPP1CB,TNFSF10,CTHRC1,ITGA10,COL15A1,SPON1,TGM2,ADSL,CCL8,TIMP1,SRGN,EGFL6,ERBB2,GPC6,THBS4,SPRY1,TYROBP,TUBG1,DAAM1,DPAGT1,ATIC,F11R,EBF1,LPAR1,CNN1,TAGLN,CILP,COL11A1,PTGS2,ING1,CXCL2,KDR,DSG2,TM4SF1	66	
Cell Death and Survival	cell viability	cell viability	6.75E-09	Increased	3.395	bias	-1.708	WBSCR22,ASS1,RRM2B,IL6,SLC9A1,POR,PPP1R3F,IP6K3,CYBA,KEAP1,MCOLN3,KIF1A,SMARCB1,TSC2,CAV1,HIPK2,UNG,SELE,COMP,MFAP5,PPP1R1B,SLX4,TNFRSF10B,MAD2L2,NPY5R,AEN,CDH5,BTG2,NCF2,PSMA4,CTSB,CD86,ACACA,SQSTM1,PTPRA,mir-21,FTH1,APOE,NME1,GADD45B,DDIT3,FGF2,SEMA6A,GDF15,CEBPD,ADIPOQ,DUSP22,CTDSPL,SYNM,DIABLO,TGM2,DUSP5,GADD45A,CCL2,SWI5,DAB2,PIK3R2,TRIM29,ADORA1,RAD21,FCGR3A/FCGR3B,LIG3,CCR1,SIGMAR1,MECOM,SPRY1,GFRA2,IGF2R,FOS,PLA2G4A,NR4A2,NTRK3,LYN,SOX9,MAP3K8,TP53BP1,PIN1,ABCC3,BMP6,ID4,LIG1,ABCB6,SOCS3,ITGB1BP1,MBP,HSPA1A/HSPA1B,PARP2,KLF6,FCER1A,TRPM8,NARFL,TYMP,DRG2,HSPA5,MYC,TGFBR2,GIMAP5,NUPR1,CXCL8,NOX4,ATF3,ADAMTS1,VEGFC,AURKAIP1,H6PD,PPP1R11,ERCC2,KLF4,FAAP20,BCL2L1,SMUG1,DUSP1,IGFBP3,CAPN2,DNAJB6,MDK,ESR1,VHL,DPH5,S100P,UBE2I,TNFAIP8,RUNX1,SULF1,CARS,SFTPD,DNASE1L3,BMP2,ATF6,CCL3,KIFC2,ETV6,IRAK1,HDGF,CIAPIN1,HLA-G,SHC1,EDN1,TIMP1,MCAM,ERBB2,ATP13A2,NDUFAF4,SRC,VCAM1,PARVA,USMG5,PLAUR,PSME3,BTK,RCAN1,CAT,SPARC,ING1,CXCL2,ALKBH3,DNM1L,PNPLA6,EIF3C,DPYD,CTGF,APOB,BMP4,SGK1,HRAS,NCSTN,NR4A3,SGPL1,RARA,ABCC1,IRS2,TXN,MCL1,BIRC7,CDKN1C,ATG7,NDRG1,GUCY1A3,FANCG,HBEGF,RPA1,IER3,HMGA1,TNK2,THBD,ROR1,LDOC1,S1PR3,MAP3K12,DOCK1,DPH2,CDH2,VKORC1,MAPK7,SFRP1,CYR61,NOTCH1,TMEM158,NRP1,PHLPP1,FYN,SCAP,ADAM17,EMILIN2,ZFP36,LEPR,CHCHD6,HYOU1,SLC1A3,TNFSF10,KAZN,MYH11,ASNS,VCAN,IDH1,UCHL1,MCOLN1,MTOR,LYZ,JUN,CST3,CSF2RA,ANXA5,SOCS2,SLC19A1,PRKCE,CD24,PTPRT,PLAT,IL11RA,PRPH,MYCN,GSTM1,PTPRK,ANGPT1,TYROBP,EGR1,MGMT,TRIM28,ACLY,AXL,DUSP14,LMO3,S100A9,CDK20,SBF1,PPP1R16B,CHFR,FCER1G,S1PR1,GPR180,PTGS2,PRPF19,TNFRSF4,SERPINI1,ADRBK1,PTPN23,FAT1,CD4,UNC5B,CXCL12,ZNF91,METAP2,CEL,IKBKG,CAMK2D,PLCE1,ETS2,PRND,IP6K1,GSK3B,GPC1,RET,BCKDK,FZD2,KLF2,PDK4,MIF,PTPRE,SPP1,EGR3,USP36,LMNA,AGTRAP,DPP9,GSR,STC1,PPP2R1A,ITGAM,ERCC1,PRKCD,RARRES3,CCL18,MAP2K5,LEP,SFRP2,ATF5,ERN1,ANTXR1,PKM,ABL1,PPP1CB,SLC7A1,TNFAIP3,SMPD1,HIF1A,NGF,PTPRF,PDCD4,HMOX1,HINT1,CD55,NFKBIA,THBS1,FLNA,DUSP10,SMO,CLOCK,RPS6KB2,KIT,PSMA3,NEK7,S100A8,MAPKAPK2,CUL9,CHEK2,PRNP,BEX2,CD59,CXCR4,RNF126,LRRK2,CSF1R,NDUFA13,THRSP,TRIM69,PRMT1,COL1A1,ENO1,EBF1,PBX3,EPHB3,NDNF,ELK1,KDR,P2RX7,MMP9,SHMT2	348	
Cancer	transformation	cell transformation	7.11E-09	Increased	4.065	 	1.523	BMP4,ITSN1,TYRO3,MAF,HRAS,SERPINA3,IL6,ODC1,HOXA9,CCND3,CAV1,DNAJA3,KAT2A,MATK,ETS1,HEYL,CDKN1C,DDIT4,MMP2,HMGA1,JUNB,SH3GL1,MN1,CCND2,BTG2,MAP3K20,MAP2K3,SFRP1,MAPK7,CYR61,PDGFD,PTPRA,NOTCH1,mir-21,FTH1,ADM,EIF4EBP2,FGF2,CDK4,RUVBL1,MCTS1,EIF4EBP1,MTOR,JUN,CSF2RA,STARD13,SOS1,RHOU,PRKCE,ASPH,LPP,FCGR3A/FCGR3B,HEY1,MYCN,MECOM,CSK,EGR1,TOB1,AXL,FOS,NTRK3,SBF1,MAP3K8,SOX9,PIN1,DNPH1,TFF3,PTPN23,TFG,PTTG1,CD4,HSPA1A/HSPA1B,KLF6,DIRAS1,BIN1,MYC,TGFBR2,RHOB,GPR4,MAP2K2,RET,ADRA1B,RASGRP2,MIF,PTPRE,SPP1,ATF3,FZD9,THRA,PAWR,SLC3A2,FOSB,BCL2L1,SDCBP,NOL3,RAP1GAP,PRKCD,RCE1,ESR1,MAP2K5,RUNX1,PEBP1,LOX,SFRP2,BMP2,TPR,ABL1,NGF,CDKN2B,ETV6,PDCD4,COL1A2,SH3D19,SHC1,NFKBIA,SMO,KIT,ERBB2,MCRS1,SRC,PAK4,PARP10,SMAD7,G6PD,CSF1R,NDUFA13,ATIC,BTK,COL1A1,RRAS2,PBX3,VAV3,CAT,ING1,EFEMP2,MMP9	136	
Cellular Movement	cellular infiltration	cellular infiltration of cells	7.22E-09	 	-0.088	 	-0.787	CTGF,CTSG,ELANE,HRAS,IL6,RARA,CAV1,TNFRSF21,ETS1,CMKLR1,SELE,NDRG1,PLEC,MMP2,THBD,NINJ1,PPP1R15A,CTSB,CD86,ITGA1,PLTP,SFRP1,CYR61,NRP1,ADM,APOE,ADAM17,FGF2,NQO2,ADIPOQ,HYOU1,TNFSF10,TGM2,CES1,GBA,CCL2,CCL3L3,STIM1,LBP,PIK3R2,GJB2,IL11RA,PLAT,CCR1,CD276,UCP2,C5AR1,SLIT2,PLA2G4A,LDLR,S100A9,PELI1,FCER1G,PROCR,MAP3K8,PTGS2,SOCS3,TNFRSF4,ADRBK1,CD36,UNC5B,CXCL12,HARS,TGFBR2,RSPO3,IKBKG,PLA2G5,LTBR,PTX3,CXCL8,MIF,SPP1,STC1,EFS,ITGAM,DUSP1,PRKCD,IGFBP3,CD14,IDO1,MDK,CCL18,AKR1B1,ESR1,C2,TNFAIP8,LEP,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,CD55,NFKBIA,EDN1,TIMP1,THBS1,MCAM,SAA1,DUSP10,CFB,S100A8,ERBB2,MAPKAPK2,ADRB2,AGT,VCAM1,NLRP3,NQO1,PCOLCE2,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,CXCL16,VAV3,SPARC,C6,CXCL2,KDR,P2RX7,MMP9	123	
Free Radical Scavenging	metabolism	metabolism of reactive oxygen species	7.39E-09	 	-0.629	 	-2.211	MSRB2,ITSN1,ELANE,CTSG,TRAP1,HRAS,SERPINA3,POMC,IL6,SPI1,MTUS1,CYBA,ABCC1,TSC2,CAV1,TXN,ETS1,SELE,DDIT4,NLRX1,CARD9,CDH5,NCF2,RTN4,TFRC,MAP2K3,ITGA1,SQSTM1,BACE2,CYR61,mir-21,FTH1,FYN,APOE,DDIT3,LEPR,FGF2,ADIPOQ,IDH1,TGM2,MTOR,CST3,PRKCE,TPO,COL18A1,FCGR3A/FCGR3B,SIGMAR1,C5AR1,UCP2,TYROBP,CSTB,CYP1B1,GRN,FOS,PLA2G4A,HP,TF,CBS/CBSL,IMMT,DHCR24,SPRY2,LYN,TAGLN,BNIP3L,FBP1,ARHGDIA,MAP3K8,PTGS2,AFG3L2,GABARAP,CYP2C8,MAOA,SOCS3,ADRBK1,CD36,CXCL12,FCER1A,GPX3,ALDH3A2,CXCL14,CLCN3,HK1,CXCL8,NOX4,MIF,SPP1,APLNR,HSPA9,THRA,ARSA,TXNRD1,STC1,ATPIF1,BCL2L1,GZMH,NOL3,ITGAM,PRSS23,SMOX,DUSP1,PRKCD,CD14,SLC25A10,AKR1B1,TXNRD2,VHL,PTGFR,SFTPD,LEP,PRDX5,BMP2,ABL1,SMPD1,MYLK,NGF,CCL3,HNRNPK,ETV6,IRAK1,HMOX1,SHC1,ALDH2,NFKBIA,SH3PXD2B,CCL13,EDN1,CFB,RPS6KB2,CYGB,S100A8,LONP1,PRNP,AGT,FAAH,SRC,VCAM1,EPAS1,LCLAT1,NQO1,G6PD,PLAUR,SH3PXD2A,FAF1,LOC102724788/PRODH,CAT,CXCL2,DNM1L,P2RX7	148	
Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of cellular protrusions	7.83E-09	Increased	2.596	bias	-1.062	SLIT3,KCNJ2,MAP6,AXIN1,CACNA1H,IL6,SLC9A1,AJUBA,TSC2,CAV1,DLG4,PLXNB2,AMHR2,TNFRSF21,STK36,MTSS1,CARMIL1,FLOT1,IFT122,FSCN1,BTG2,NCF2,ARHGEF6,ATMIN,ACACA,ITGA1,mir-21,APOE,NME1,PLXNA3,TTLL3,EIF4EBP2,FGF2,GDF15,ADIPOQ,CCL2,LLGL1,CUL7,GFRA2,PVR,GRN,MYO5A,FOS,ARHGEF5,MYOC,SWAP70,NTRK3,LYN,AFG3L2,BMP6,MT2A,NCDN,MICALL2,DPYSL4,MBP,CEP104,MYC,NNMT,ADGRF5,RHOB,MAP2K2,CAST,MARCO,CXCL8,ATF3,MAPK8IP2,RIMS4,CAPG,TXNRD1,CDC42BPB,MATN2,CAPN2,VHL,SULF1,TMEM138,LOX,FAM107A,CDC20,BMP2,FLRT1,CLUAP1,ATF6,HNRNPK,PHLDB2,SHC1,MKL2,ERBB2,AGT,THBS4,SRC,PKP1,PARVA,KIF3B,BTK,PMP22,CAPNS1,KIF5B,VAV3,SPARC,TBC1D7,DNM1L,CTGF,ITSN1,SGK1,HRAS,POMC,RAPH1,EVI5L,ITGA3,VEGFD,TESK1,MATK,RND2,ARHGEF4,RIMS3,ATG7,CHN1,PLEC,THY1,GRK5,CEP89,TNK2,ROR1,NINJ1,S1PR3,DOCK1,SRGAP3,CDH2,BSG,PIP5K1C,STIP1,RTN4,GDPD5,LRP8,CAPRIN1,CYR61,NOTCH1,B9D1,NRP1,SPTBN1,AKAP12,FYN,RALA,ATP6V1D,TCTN1,BTG3,WASF3,EFHD1,DCLK1,EIF4EBP1,ENAH,UCHL1,EFNB2,ID1,KLF9,MTOR,JUN,RHOD,SRGAP1,RHOU,SNX10,CLMN,PRKCE,NPTXR,NCKIPSD,PLAT,IL11RA,PTK7,CEP164,PTPRK,EGR1,SLIT2,RELN,PLEKHG6,WAS,TENM4,ADCY1,S1PR1,DBNL,PTGS2,RUFY3,TM4SF1,RAB3IP,PFN1,FARP1,PTPN23,MAP1B,MNS1,CXCL12,SDC4,CDC42EP2,DYNLT1,PLEKHG4,PARVB,WDR5,CRIP1,BRSK1,NEO1,GSK3B,C1QBP,RET,MYO10,RTN4R,FERMT3,TTYH1,PTPRE,EGR3,ACAP1,MAPK8IP3,RAP1GAP,SNX1,--,GDI1,ICK,RNF165,LEP,NFIX,EPB41L3,NLGN1,VAPA,ABL1,SMPD1,NGF,PTPRF,PRKCSH,TNFRSF12A,EPHB6,RAB5A,NFKBIA,ANGPTL4,FLNA,DKK3,THBS1,KIT,MICALL1,NSMF,SULF2,MAPKAPK2,MYO16,PI4KB,PRNP,PAK4,CXCR4,LRRK2,TRIP6,PRMT1,KIF2A,LPAR1,EPHB3,EDNRA,GAP43,ELK1,KDR,RTN3,P2RX7	255	
Cellular Development, Tissue Development	differentiation	differentiation of connective tissue	8.47E-09	 	-0.546	 	-1.656	AXIN1,IL6,SPI1,ATP2A2,SLC9A1,POR,EGR2,GNA15,LUM,SMARCB1,MGP,ATF4,EBF2,HIPK2,FBL,SLC2A5,ETS1,TNFRSF10B,MN1,PDLIM7,TFRC,SQSTM1,mir-21,APOE,GADD45B,DDIT3,FGF2,SLC1A5,ADIPOQ,CEBPD,CTHRC1,CCL2,OSBPL11,LY6E,HEY1,CCR1,MECOM,ZNF521,TOB1,TRIB3,ID3,GLG1,GRN,FOS,ZFPM2,MYOC,NR4A2,LYN,BMPER,SOX9,PIN1,BMP6,ID4,SOCS3,NOC3L,RARRES2,PARP2,ZFPM1,GPC3,MYC,TGFBR2,ADGRF5,CAST,CXCL8,ATF3,THRA,PTGDS,KLF4,BCL2L1,H3F3A/H3F3B,MDK,RUNX1,ANGPTL8,PTGFR,FRZB,BMP2,CCL3,ETV6,SH3PXD2B,COL6A1,EDN1,TIMP1,IARS,AGT,SRC,NLRP3,AP1S2,SMAD6,PLAUR,ZNF16,BSCL2,NFE2L1,BTK,RRAS2,CAPNS1,CAT,FECH,BMP4,CTGF,TGFBR3,MAF,HRAS,NR4A3,PEG10,LPIN1,RARA,VEGFD,IRS2,WNT5B,SFRP4,CMKLR1,RRBP1,THY1,GRK5,JUNB,CREB5,BCAP29,MAP3K12,NR1D1,ALAS2,LRP8,MAP2K3,SFRP1,CYR61,NOTCH1,NRP1,ADM,FYN,TCEA1,ATAT1,TNFSF10,GPC4,ATP6AP1,VCAN,MAFG,ID1,EFNB2,MTOR,JUN,CCL3L3,CST3,SNX10,PRKCE,CD276,C5AR1,TYROBP,SLIT2,AXL,P4HTM,LMO3,TF,WAS,FCER1G,PTGS2,FBN2,TBX15,ASXL2,ITGA11,OSR1,GSK3B,PDK4,EIF2AK1,AXIN2,PTPRE,MIF,DNASE2,SPP1,LMNA,FZD9,STC1,ATPIF1,PRKCD,ADAMTS7,SMAP1,SFRP2,LEP,ATF5,ABL1,UBASH3B,HIF1A,TNFRSF12A,HMOX1,TMEM119,HSPE1,SMO,KIT,S100A8,HCST,ALPL,PTGER4,ADRB2,EPAS1,SMAD7,ANKRD54,ZBTB7C,CCDC3,CSF1R,PRMT1,EMP1,FAF1,EBF1,LPAR1,NUCB2,EDNRA,ELK1,NCKAP1L,MMP9,CARM1	208	
Cellular Movement	homing	homing of blood cells	8.50E-09	 	-1.122	bias	-4.438	BMP4,CTSG,ELANE,MST1,SERPINA3,IL6,SPI1,HOXA9,VEGFD,TXN,CMKLR1,SELE,PLEC,ANO6,FLOT1,NINJ1,S1PR3,AQP9,YARS,PIP5K1C,ITGA1,FYN,APOE,ADAM17,DAPK2,NQO2,GNA11,ACKR2,G6PC3,CCL3L1,CCL2,CCL8,CCL3L3,CSF2RA,CST3,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CD69,DEFB1,SLIT2,GRN,HP,SWAP70,LDLR,S100A9,WAS,LSP1,LYN,FCER1G,S1PR1,NEDD9,RGS1,SOCS3,RARRES2,PFN1,CD4,SPHK2,CXCL12,MYC,RHOB,CXCL14,LTBR,C1QBP,MARCO,CSF3R,ELN,CXCL8,MIF,SPP1,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,MDK,CCL18,RUNX1,AOC3,LITAF,SFTPD,MYLK,CCL3,NGF,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,ENPP2,S100A8,ERBB2,MAPKAPK2,PRNP,THBS4,MMP28,CXCR4,NQO1,PLAUR,LRRK2,CSF1R,TNFRSF14,CXCL16,VAV3,EDNRA,NCKAP1L,CXCL2,KDR,MMP9	116	
Free Radical Scavenging, Molecular Transport	quantity	quantity of reactive oxygen species	8.76E-09	 	-0.802	 	-0.379	APOB,PFN1,HRAS,MYC,HSPA4,PGD,ADGRF5,CYBA,KEAP1,TXN,KLF2,EIF2AK1,CXCL8,NOX4,ATG7,HSPA9,HMGA1,GPX7,STC1,GSR,BCL2L1,NCF2,FTH1,ADM,APOE,SFTPD,LEP,OSGIN1,PRDX5,LEPR,ABL1,ADIPOQ,SMPD1,NGF,HMOX1,SHC1,CA3,MTOR,NFKBIA,JUN,EDN1,CCL2,CYGB,MAPKAPK2,ABCC9,NDUFAB1,LONP1,PRNP,AGT,UCP2,ANGPT1,NQO1,G6PD,MT1A,CSF1R,NFE2L1,LDLR,CAT,PTGS2,DNM1L,MAOA	61	
Cell Death and Survival	cell death	cell death of colorectal cancer cell lines	8.81E-09	Decreased	-2.015	 	-1.893	TFF3,GMDS,VPS28,SGK1,AXIN1,COX8A,SPHK2,TRAP1,HRAS,AP2A2,TGFBR2,PADI4,MYC,G0S2,AHSA1,CSE1L,CYBA,GSK3B,LTBR,HIPK2,MCL1,ETS1,BIRC7,MIF,CDKN1C,ATG7,SPP1,ATF3,NDRG1,PPP1R1B,TNFRSF10B,LMNA,TXNRD1,BCL2L1,TRIM39,PRKCD,PPP1R15A,ATMIN,IGFBP3,CAPN2,SQSTM1,TRIAP1,NOTCH1,MLKL,PMEPA1,PHLPP1,RUNX1,ADAM17,LEP,CDC20,DDIT3,DAPK2,FGF2,BTG3,GDF15,PKM,ABL1,TNFSF10,NAA35,NGF,DIABLO,TGM2,HMOX1,HINT1,RABL6,NFKBIA,EDN1,GADD45A,TIMP1,ERBB2,HCST,TRIM29,COL18A1,LONP1,CHEK2,SRC,CXCR4,RTKN,MGMT,SMAD7,IGF2R,TNFRSF14,NR4A2,NTRK3,LIMS1,MT1F,SPARC,SOX9,PTGS2,DSG2	90	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by leukocytes	1.05E-08	 	-0.340	 	-1.049	CTGF,CTSG,ELANE,HRAS,IL6,RARA,CAV1,TNFRSF21,ETS1,CMKLR1,SELE,NDRG1,PLEC,MMP2,THBD,NINJ1,PPP1R15A,CTSB,CD86,ITGA1,PLTP,SFRP1,CYR61,ADM,APOE,ADAM17,NQO2,ADIPOQ,HYOU1,TNFSF10,TGM2,CES1,GBA,CCL2,CCL3L3,STIM1,LBP,PIK3R2,GJB2,IL11RA,PLAT,CCR1,CD276,UCP2,C5AR1,SLIT2,PLA2G4A,LDLR,S100A9,PELI1,FCER1G,PROCR,MAP3K8,PTGS2,SOCS3,TNFRSF4,ADRBK1,CD36,UNC5B,CXCL12,HARS,TGFBR2,RSPO3,IKBKG,PLA2G5,LTBR,PTX3,CXCL8,MIF,SPP1,STC1,EFS,ITGAM,DUSP1,PRKCD,IGFBP3,CD14,IDO1,MDK,CCL18,ESR1,C2,TNFAIP8,LEP,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,CD55,NFKBIA,EDN1,THBS1,TIMP1,DUSP10,MCAM,SAA1,CFB,S100A8,ERBB2,MAPKAPK2,ADRB2,AGT,VCAM1,NLRP3,NQO1,PCOLCE2,SMAD7,HYAL1,LRRK2,NFKBIZ,CSF1R,CXCL16,VAV3,SPARC,C6,CXCL2,KDR,P2RX7,MMP9	120	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	homing	homing of leukocytes	1.14E-08	 	-1.030	bias	-4.321	CTSG,ELANE,MST1,SERPINA3,IL6,SPI1,HOXA9,VEGFD,TXN,CMKLR1,SELE,PLEC,ANO6,FLOT1,NINJ1,S1PR3,AQP9,YARS,PIP5K1C,ITGA1,FYN,APOE,ADAM17,DAPK2,NQO2,GNA11,ACKR2,G6PC3,CCL3L1,CCL2,CCL8,CCL3L3,CSF2RA,CST3,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CD69,DEFB1,SLIT2,GRN,HP,SWAP70,LDLR,S100A9,WAS,LSP1,LYN,FCER1G,S1PR1,NEDD9,RGS1,SOCS3,RARRES2,PFN1,CD4,SPHK2,CXCL12,MYC,RHOB,CXCL14,LTBR,C1QBP,MARCO,CSF3R,ELN,CXCL8,MIF,SPP1,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,MDK,CCL18,RUNX1,AOC3,LITAF,SFTPD,MYLK,CCL3,NGF,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,ENPP2,S100A8,ERBB2,MAPKAPK2,PRNP,THBS4,MMP28,CXCR4,NQO1,PLAUR,LRRK2,CSF1R,TNFRSF14,CXCL16,VAV3,EDNRA,NCKAP1L,CXCL2,KDR,MMP9	115	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	colorectal adenoma	colorectal adenoma	1.21E-08	 	 	 	 	SLIT3,PHLDA1,C1orf115,AXIN1,NTMT1,CA12,CES2,GTF2IRD1,ODC1,AJUBA,SLC7A5,UNG,PDK4,SMPDL3A,PTGIS,AXIN2,DPT,BCL2L1,C9orf16,SORD,MRPL17,SLC22A5,BACE2,BYSL,CCDC80,EPB41L3,SCARA5,DNASE1L3,LEPR,CDK4,RUVBL1,CDKN2B,POLR1C,TIMP1,CLMN,HSD11B2,ASAP3,PTPRT,CCDC68,PSAT1,SRC,ATP2C1,SLC12A2,DGAT2,VSIG4,TRIB3,SLIT2,POLD1,PLA2G2A,C2orf88,SLC48A1,ATP6V1F,LPAR1,PAG1,JCHAIN,ANXA3,EPHB3,NR5A2,ITM2C,NLE1,SOX9,RDH5,PTGS2	63	
Cardiovascular System Development and Function	development	development of vasculature	1.26E-08	 	 	 	 	BMP4,RRM2B,TYRO3,CACNA1H,IL6,SPI1,MFAP2,SLC4A3,ITGA3,RARA,LUM,MGP,CAV1,PLXNB2,HEY2,TMBIM1,TNFRSF21,PTGIS,CALCRL,SELE,GUCY1A3,MFAP5,C1GALT1C1,MMP2,PLOD1,CDH2,CDH5,CTSB,MAPK7,CYR61,NOTCH1,COL3A1,B9D1,NRP1,ADM,APOE,ADAM17,CFC1/CFC1B,MYH11,MEOX2,COL15A1,COL5A1,EFNB2,ID1,JUN,CST3,LLGL1,COL18A1,CYP51A1,GJB2,HEY1,IL11RA,MYCN,ANGPT1,CUL7,CDO1,AXL,ID3,LDLR,CBS/CBSL,NTRK3,SERPINH1,CNN1,ARHGDIA,GPR180,ARID4A,FBN2,ADGRA2,CXCL12,SDC4,GPC3,METAP2,MYC,TGFBR2,RHOB,GPR4,COMT,SIAH2,KLF2,TEK,ELN,SPP1,SLC4A7,VEGFC,SGCB,MAPK8IP3,NOL3,PKD1,RGN,COMMD1,CAPN2,FZD5,VHL,MAP2K5,RUNX1,LOX,SFRP2,NLGN1,ERN1,BMP2,HIF1A,RAMP2,HMOX1,SHC1,ANGPTL4,EDN1,FLNA,THBS1,MKL2,ENPP2,PTGER4,AGT,SRC,PAK4,EPN1,EPAS1,CXCR4,G6PD,COL1A1,VAV3,CAT,EDNRA,KDR,EFEMP2	124	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of tumor cells	1.39E-08	 	-1.526	 	-0.633	EIF3C,BMP4,SGK1,RAN,HRAS,SERPINA3,IL6,SPI1,EIF3B,CCND3,CSE1L,RARA,KEAP1,CAV1,TXN,HIPK2,MCL1,TNFRSF21,ETS1,BIRC7,CAPN6,ATG7,NDRG1,TNFRSF10B,MAD2L2,HBEGF,TIMP4,BSG,RTN4,CTSB,PSMA4,RPL6,EBNA1BP2,ITGA1,SFRP1,MAPK7,CYR61,PTPRA,NOTCH1,mir-21,PHLPP1,NRP1,ZFP36,DDIT3,FGF2,LEPR,GDF15,ADIPOQ,TNFSF10,SF3B3,DIABLO,TRIB1,MTOR,JUN,GADD45A,CD24,PRKCE,COL18A1,RPS24,MYCN,BRMS1,ACLY,FOS,NR4A2,MCM2,TF,SPRY2,PROCR,PIN1,PTGS2,BMP6,PHLDA1,SOCS3,HSPA1A/HSPA1B,CXCL12,TPM1,MYC,TGFBR2,RHOB,CARD8,GSK3B,PUF60,BIRC3,TEK,CXCL8,MIF,PSMB5,NUP155,HSPA9,POLR2H,VEGFC,PAWR,RPL9,STC1,BCL2L1,PRKCD,IGFBP3,VHL,MAP2K5,UBE2I,RUNX1,SFRP2,LEP,BMP2,ABL1,HIF1A,NGF,HMOX1,DHCR7,NFKBIA,TIMP1,KIT,PSMA3,ISCU,ERBB2,SEMA3B,PRNP,BEX2,CD59,VCAM1,SNRPB,CXCR4,PLAUR,LRRK2,RPS21,TNFRSF14,BTK,ENO1,LPAR1,CAT,EDNRA,SPARC,TSC22D1,KDR,MMP9,RPLP0	136	
Cellular Assembly and Organization, Cellular Function and Maintenance, Tissue Development	formation	formation of actin filaments	1.67E-08	 	1.496	 	-0.325	CTGF,PFN1,MSRB2,BMP4,ITGB1BP1,MICALL2,RGCC,CXCL12,HRAS,TPM1,CDC42EP2,SDC4,COBL,SLC9A1,TGFBR2,ITGA3,ADGRF5,BOP1,RHOB,GPR4,MYADM,KANK3,CAV1,KLF2,TESK1,ELN,CXCL8,NOX4,MIF,SELE,MTSS1,GNG2,CARMIL1,THY1,MMP2,PTGDS,JUNB,MLST8,HAX1,UBXN11,LMCD1,KANK1,CORO7/CORO7-PAM16,CDC42BPB,PRKCD,PTPRA,FYN,LEP,FGF2,GNA11,WASF3,ABL1,CDK4,MYLK,MSRB1,MYH11,PHLDB2,MTOR,EDN1,CCL2,NET1,SORBS1,RHOD,STARD13,PRKCE,DAB2,ARHGEF2,PIK3R2,GNG5,ADORA1,ASAP3,COL18A1,NCKIPSD,PTGER4,PLAT,AGT,SRC,VCAM1,PAK4,RTKN,SLIT2,SH3PXD2A,ARHGEF5,KCTD13,MYOC,PLEKHG6,LPAR1,WAS,SPRY2,S1PR1,EDNRA,SPARC,GAP43,KDR,NCKAP1L	95	
Cell Death and Survival	cell death	cell death of epithelial cells	1.73E-08	 	-1.887	 	-2.396	BMP4,SGK1,HRAS,MST1,POMC,IL6,MIA,SGPL1,MCOLN3,ABCC1,HIPK2,ALDH3A1,MCL1,PTGIS,ATG7,NDRG1,TNFRSF10B,MMP2,IER3,HAX1,CDH2,PPP1R15A,CTSB,GAPDH,TFRC,SFRP1,mir-21,SPTBN1,FYN,GADD45B,DDIT3,FGF2,NQO2,GDF15,CEBPD,ADIPOQ,TNFSF10,CASP4,TGM2,EFNB2,ID1,CA3,MTOR,JUN,GADD45A,DAP3,DAB2,RASSF5,NDUFAB1,RAD21,PLAT,MYCN,MECOM,EMP3,EGR1,CUL7,TRIB3,SRXN1,FOS,PLA2G4A,KRT8,MYOC,LDLR,CBS/CBSL,NTRK3,BMF,LYN,PEA15,S1PR1,FKBP4,BNIP3L,MAP3K8,PTGS2,BMP6,MAOA,RFXANK,SOCS3,TFF3,ADRBK1,CD4,UNC5B,SPHK2,HSPA5,MYC,TGFBR2,TNIP1,IKBKG,ALDH1A1,GSK3B,BIRC3,HK1,CXCL8,TJP2,SPP1,ATF3,PAWR,BCL2L1,NOL3,ERCC1,TRIM39,PKD1,PRKCD,IGFBP3,RGN,ALDH3B1,ESR1,MLKL,LEP,ERN1,SMPD1,MYLK,IRF3,NGF,HMOX1,ALDH2,SHC1,NFKBIA,EDN1,TIMP1,SAA1,ERBB2,NCL,MAPKAPK2,ATP13A2,PRNP,FAAH,SLC20A1,SRC,NLRP3,PLAUR,CSF1R,PRMT1,FAIM,RBCK1,EMP1,PMP22,RRAS2,CAT,SPARC,ELK1,DNM1L,TNFRSF19,P2RX7,SLC47A1	144	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of breast cancer cell lines	1.88E-08	Increased	2.526	 	0.616	EIF3C,CTGF,HRAS,NCSTN,IL6,SLC9A1,ODC1,MTUS1,CSE1L,RARA,SMARCB1,CAV1,IRS2,TXN,CDC16,MATK,ETS1,PPP1R1B,FLOT1,HBEGF,MBD2,HMGA1,IER3,DVL2,CCND2,PIP5K1C,BTG2,MAP2K3,MAPK7,CYR61,mir-21,NRP1,NME1,ADAM17,NACC2,ZFP36,OSGIN1,FGF2,CHCHD6,GDF15,ADIPOQ,CEBPD,TNFSF10,H2AFZ,ENAH,EIF4EBP1,ID1,MTOR,RABL6,TADA3,JUN,SLC19A1,DAB2,PRKCE,ACSL4,S100A1,UBE2M,TRIM28,RGS16,COPS3,GRN,FOS,KRT8,WBP2,CYP2C8,PFN1,HAVCR2,TPM1,HSPA5,BIN1,MYC,TGFBR2,PARVB,CTSD,IKBKG,ETS2,KPNA2,C1QBP,GPC1,TEK,PTPRE,SPP1,ADAMTS1,GPS2,USP36,ZNF282,FOXC1,KLF4,BCL2L1,PPP2R1A,COL6A3,TRIM39,SMOX,PRKCD,IGFBP3,RARRES3,CRABP2,ESR1,VHL,UBE2I,TNFAIP8,LEP,PKM,MYLK,HIF1A,NGF,HNRNPK,RAP1GDS1,SHC1,NFKBIA,PCK2,CSPG4,ERBB2,SEMA3B,NDUFAF3,BEX2,NDUFAF4,SRC,CD59,TAF6,CXCR4,RTKN,NQO1,RNF126,PLAUR,RBCK1,CAT,UBA1,ELK1,KDR	130	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of macrophages	1.99E-08	 	1.082	 	-0.603	RARRES2,CTGF,PFN1,CTSG,CXCL12,HRAS,MST1,HOXA9,TGFBR2,IKBKG,RHOB,CAV1,STAB1,TNFRSF21,PTX3,ELN,CXCL8,MIF,CMKLR1,SPP1,NDRG1,PLEC,PTGDS,THBD,NINJ1,APBA3,STC1,PRKCD,PPP1R15A,ITGA1,MDK,PLTP,CYR61,CNN2,APOE,SFTPD,LITAF,ADAM17,LEP,NQO2,ABL1,ADIPOQ,TNFAIP3,MYLK,HIF1A,CCL3,G6PC3,VCAN,HMOX1,CES1,GBA,EDN1,CCL2,CCL3L3,THBS1,FLNA,DUSP10,SAA1,ERBB2,MAPKAPK2,HCAR2,PRNP,AGT,CCR1,C5AR1,NLRP3,EPAS1,MMP28,TYROBP,CXCR4,PCOLCE2,NQO1,SMAD7,LRRK2,DEFB1,SLIT2,CSF1R,PLA2G4A,LDLR,S1PR1,MAP3K8,PTGS2,C6,KDR,P2RX7	85	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of mononuclear leukocytes	2.04E-08	 	-0.910	bias	-3.520	CTGF,CTSG,HRAS,MST1,SERPINA3,IL6,SGPL1,ITGA3,EGR2,ABCC1,MYADM,TNFRSF21,ETS1,CMKLR1,SELE,PLEC,ANO6,NINJ1,S1PR3,YARS,PIP5K1C,CD86,ITGA1,MAPK7,PTPRA,NOTCH1,FYN,APOE,ADAM17,NQO2,GNA11,ACKR2,HYOU1,TNFSF10,TGM2,EFNB2,JUN,CCL3L1,CCL8,CCL2,CCL3L3,SOS1,RASSF5,PIK3R2,GJB2,IL11RA,CCR1,CD209,UCP2,ANGPT1,CD69,HDC,RGS16,DEFB1,PVR,GPR183,FOS,F11R,HP,SWAP70,LDLR,WAS,PELI1,S1PR1,PROCR,PTGS2,NEDD9,QPCT,RGS1,SOCS3,RARRES2,TNFRSF4,CD4,UNC5B,SPHK2,CXCL12,FCER1A,HARS,TGFBR2,CYP26B1,IKBKG,STAB1,LTBR,FAM65B,KLF2,FERMT3,ELN,CXCL8,MIF,SPP1,GNAZ,EFS,ITGAM,RAP1GAP,PRKCD,CCL18,ESR1,RUNX1,AOC3,LEP,SMPD1,MYLK,NGF,CCL3,ETV6,HLA-G,HMOX1,SHC1,CD55,NFKBIA,CCL13,TIMP1,THBS1,MCAM,SAA1,ENPP2,ERBB2,PRNP,AGT,SRC,VCAM1,NLRP3,CXCR4,NQO1,PLAUR,NFKBIZ,TNFRSF14,BTK,CXCL16,COL1A1,CYTIP,VAV3,SPARC,C6,KDR,P2RX7,MMP9	137	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of leukocytes	2.17E-08	 	-0.692	bias	-3.929	CTSG,ELANE,MST1,SERPINA3,IL6,SPI1,HOXA9,VEGFD,TXN,CMKLR1,SELE,PLEC,ANO6,FLOT1,NINJ1,S1PR3,AQP9,YARS,PIP5K1C,ITGA1,FYN,APOE,ADAM17,DAPK2,GNA11,ACKR2,G6PC3,CCL3L1,CCL2,CCL8,CCL3L3,CSF2RA,CST3,STIM1,LBP,ADORA1,HCAR2,CCR1,C5AR1,ANGPT1,ZNF580,CD69,DEFB1,SLIT2,GRN,HP,SWAP70,LDLR,S100A9,WAS,LSP1,LYN,S1PR1,FCER1G,NEDD9,RGS1,SOCS3,PFN1,RARRES2,CD4,SPHK2,CXCL12,RHOB,CXCL14,C1QBP,MARCO,CSF3R,CXCL8,ELN,MIF,SPP1,VEGFC,CAPG,GNAZ,TPSAB1/TPSB2,ITGAM,RAP1GAP,MDK,CCL18,LITAF,SFTPD,MYLK,CCL3,NGF,HLA-G,SHC1,CCL13,EDN1,THBS1,SAA1,S100A8,ERBB2,MAPKAPK2,PRNP,THBS4,MMP28,CXCR4,PLAUR,LRRK2,CSF1R,TNFRSF14,CXCL16,VAV3,EDNRA,NCKAP1L,CXCL2,KDR,MMP9	108	
Cellular Growth and Proliferation	colony formation	colony formation of cells	2.24E-08	 	0.997	 	0.169	ITSN1,TYRO3,HRAS,IL6,EIF6,SPI1,HOXA9,SMARCB1,P3H1,TSC2,LUM,CAV1,DNAJA3,ALDH3A1,ETS1,BIRC7,ATG7,NDRG1,MT1X,MMP2,HMGA1,JUNB,PPP1R15A,CTSB,ITGA1,SFRP1,SQSTM1,CYR61,NOTCH1,mir-21,AKAP12,ADAM17,RALA,GADD45B,DDIT3,FGF2,ADIPOQ,TNFSF10,RUVBL1,VCAN,EIF4EBP1,DIABLO,ID1,KAT2B,JUN,CCL2,GADD45A,CCL3L3,CSF2RA,SOCS2,TRIT1,SH3GLB2,RASSF5,HCAR2,S100A1,MAPKAP1,MECOM,SPRY1,EGR1,GRN,FOS,KRT8,LMO3,NTRK3,SPRY2,CHFR,PEA15,BNIP3L,PTGS2,PIN1,ID4,PHLDA1,VPS28,TFG,PTTG1,CD4,HSPA1A/HSPA1B,KLF6,CXCL12,GPC3,BIN1,MYC,CTSD,ALDH1A1,RHOB,NUPR1,KPNA2,C1QBP,RET,TEK,PTX3,CSF3R,MIF,SPP1,ATF3,DOK2,HSPA9,BAMBI,THRA,KLF4,RASD1,SLC3A2,BCL2L1,CCNG2,LIMA1,IGFBP3,MDK,ESR1,VHL,RUNX1,LOX,IGFBP4,LEP,SFRP2,EPB41L3,ABL1,IRF3,HIF1A,NGF,CCL3,PTPRF,ETV6,HDGF,HMOX1,SHC1,NFKBIA,EDN1,MCAM,KIT,ERBB2,SEMA3B,SRC,EPAS1,SMAD7,MKNK2,SERTAD1,CSF1R,ATIC,ENO1,RCAN1,VAV3,CAT,SPARC,ING1,MMP9	145	
Organismal Injury and Abnormalities	edema	Edema	2.25E-08	 	-1.063	bias	1.863	CA5B,CA12,HRAS,IL6,ATP2A2,POR,CCND3,CAV1,VEGFD,HEY2,SELE,CALCRL,SCNN1D,RAD51D,ROR1,S1PR3,DOCK1,CTSA,CCND2,PPP1R15A,TFRC,SFRP1,MAPK7,NOTCH1,ADM,MME,FCGRT,ADAM17,TCEA1,ADIPOQ,CDK4,FKBP1A,ABCA5,C1R,CA3,DTNA,JUN,COL18A1,PLAT,SOX7,MYCN,C5AR1,ANGPT1,MECOM,IGF2R,PLA2G4A,ZFPM2,KIF7,LDLR,ATP1A2,MS4A2,PROCR,DBNL,NR5A2,PTGS2,ADRA1A,SERPINI1,ADRBK1,CA4,TYMP,GUSB,MYC,TGFBR2,IKBKG,PTGES2,MYOM1,OSR1,KLF2,ADRA1B,CXCL8,PKP2,VEGFC,PTGDS,PKD1,ADRA2A,DUSP1,CD14,MEGF8,ESR1,SFRP2,LEP,SLC4A11,FLRT2,ABL1,HIF1A,RAMP2,HMOX1,MAN2C1,ANGPTL4,EDN1,FLNA,MKL2,ENPP2,HCST,PTGER4,ADRB2,PRNP,NLRP3,CXCR4,SLC12A2,UPP1,SMAD7,NFKBIZ,BTK,PBX3,EDNRA,KDR	107	
Free Radical Scavenging	synthesis	synthesis of reactive oxygen species	2.27E-08	 	-0.883	 	-2.342	MSRB2,ITSN1,ELANE,CTSG,TRAP1,HRAS,SERPINA3,POMC,IL6,SPI1,MTUS1,CYBA,ABCC1,TSC2,CAV1,ETS1,SELE,DDIT4,NLRX1,CARD9,CDH5,NCF2,RTN4,TFRC,MAP2K3,ITGA1,SQSTM1,BACE2,CYR61,FTH1,FYN,APOE,DDIT3,FGF2,LEPR,ADIPOQ,IDH1,TGM2,MTOR,CST3,PRKCE,TPO,COL18A1,FCGR3A/FCGR3B,SIGMAR1,C5AR1,UCP2,TYROBP,CSTB,CYP1B1,GRN,FOS,PLA2G4A,HP,TF,CBS/CBSL,DHCR24,IMMT,SPRY2,LYN,TAGLN,BNIP3L,FBP1,ARHGDIA,MAP3K8,AFG3L2,GABARAP,PTGS2,CYP2C8,MAOA,SOCS3,ADRBK1,CD36,CXCL12,FCER1A,ALDH3A2,CXCL14,CLCN3,HK1,CXCL8,NOX4,MIF,SPP1,APLNR,HSPA9,THRA,ARSA,TXNRD1,STC1,ATPIF1,BCL2L1,GZMH,NOL3,ITGAM,PRSS23,SMOX,DUSP1,PRKCD,CD14,SLC25A10,AKR1B1,TXNRD2,VHL,PTGFR,SFTPD,LEP,BMP2,ABL1,SMPD1,MYLK,NGF,CCL3,HNRNPK,ETV6,IRAK1,HMOX1,SHC1,ALDH2,NFKBIA,CCL13,EDN1,CFB,RPS6KB2,S100A8,LONP1,PRNP,AGT,FAAH,SRC,VCAM1,EPAS1,LCLAT1,NQO1,G6PD,PLAUR,FAF1,LOC102724788/PRODH,CAT,DNM1L,CXCL2,P2RX7	141	
Skeletal and Muscular System Development and Function	function	function of muscle	2.42E-08	 	-0.196	bias	-2.543	KCNJ2,IL6,ATP2A2,IDUA,ITGA3,GAA,CAV1,HEY2,CASQ2,HEYL,GUCY1A3,PLEC,HBEGF,MMP2,IER3,JUNB,DOCK1,TIMP4,ITGA7,ADM,SORL1,APOE,FGF2,GDF15,ADIPOQ,FKBP1A,MYH11,MEOX2,MCOLN1,MTOR,PRKCE,ASPH,ADORA1,ABCC9,MYH1,PLAT,HEY1,S100A1,COL12A1,POMGNT1,LAMP2,LIMS1,FLNC,GPBAR1,ATP1A2,PTGS2,MAMSTR,SGCD,MAOA,ADRBK1,PFKFB1,AK1,PLCE1,PLA2G5,NEDD4L,BIRC3,ADRA1B,ACTA1,KCNJ8,FST,SPP1,APLNR,SGCG,LAMA2,H6PD,LMNA,SGCB,THRA,INHBB,STC1,ERCC1,NOL3,SRPK3,DUSP1,HIF1AN,IGFBP3,MAP2K5,SULF1,IGFBP4,LEP,PPP1R1A,HMOX1,SHC1,EDN1,KCNMA1,THBS1,RPS6KB2,SULF2,IFRD1,PTGER4,ADRB2,AGT,PRNP,MTMR14,SMAD7,ENO1,VAV3,CAT,NUCB2,GBE1,NDNF,DNM1L,XK,EFEMP2,MMP9	105	
Cell Death and Survival	apoptosis	apoptosis of vascular endothelial cells	2.51E-08	 	0.011	 	-0.166	ADM,LEP,ITSN1,DDIT3,FGF2,CD36,ADIPOQ,CXCL12,TNFSF10,HSPA5,HMOX1,NR4A3,ALDH2,RGS5,THBS1,MCAM,CAV1,PRKCE,S100A8,GSK3B,SEMA3B,COL18A1,CXCL8,COMP,SPP1,UCP2,ATF3,ANGPT1,TNFRSF10B,MMP2,AXL,BCL2L1,CAT,HIF1AN,KDR,MMP9,mir-21,RBP4	38	
Cell Death and Survival	apoptosis	apoptosis of lymphoma cell lines	2.77E-08	 	-0.641	 	-0.719	CD4,CXCL12,FCER1A,SERPINA3,IL6,CBX5,SPI1,MYC,CCND3,RARA,CARD8,HDAC11,BIRC3,MCL1,ITPR2,TNFRSF10B,BCL2L1,DUSP1,IGFBP3,IDO1,NOTCH1,mir-21,RUNX1,CNN2,IGFBP4,DDIT3,ERN1,FGF2,LEPR,BMP2,ABL1,TNFSF10,CASP4,DIABLO,TGM2,MTOR,CD55,NFKBIA,JUN,SMO,CD24,NCL,CHEK2,FCER2,NDUFAF4,CD59,MECOM,CXCR4,EGR1,SMAD7,BTK,EBF1,WAS,BMF,LSP1,CAT,LYN,ARHGDIA,SOX9,RPLP0	60	
Cellular Development	differentiation	differentiation of tumor cell lines	2.80E-08	 	-0.193	 	-1.780	BMP4,CTGF,AXIN1,CTSG,HRAS,IL6,SPI1,ATP2A2,ODC1,SGPL1,GNA15,AJUBA,RARA,KEAP1,TSC2,SMARCB1,ATF4,IRS2,TMBIM1,MCL1,MATK,NDRG1,MAD2L2,THY1,THBD,MAP3K12,DVL2,BTG2,CYR61,NOTCH1,NME1,DDIT3,FGF2,LEPR,NID2,CDK4,CEBPD,CTDSPL,VCAN,TGM2,ID1,MTOR,JUN,KAT2B,CSF2RA,SRGAP1,CMTM8,DAB2,PRKCE,STIM1,COL18A1,ACVR1C,PLAT,CTSK,EGR1,RELN,ID3,FOS,SPRY2,LYN,PTGS2,ADRA1A,SOCS3,PRPF19,AKR1C3,MYC,ETS2,GSK3B,C1QBP,RET,MIF,FST,STK39,FZD9,THRA,GNAZ,KLF4,BCL2L1,TRAPPC9,ITGAM,SRPK3,DUSP1,PRKCD,CD14,ESR1,VHL,ETV5,RUNX1,PA2G4,BMP2,ABL1,AUP1,HIF1A,NGF,ETV6,SHC1,HMOX1,NFKBIA,TIMP1,KIT,ERBB2,PTGER4,BEX2,SRC,PAK4,ATP2C1,SMAD6,SMAD7,PLAUR,SCIN,PRMT1,ENO1,RRAS2,SPARC	114	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of granulocytes	2.92E-08	 	-1.594	 	-3.809	CTGF,CTSG,ELANE,POMC,IL6,SPI1,LUM,TXN,CMKLR1,SELE,FLOT1,THBD,AQP9,YARS,PIP5K1C,RTN4,CTSB,ITGA1,PLTP,SFRP1,ADM,CNN2,APOE,ADAM17,DAPK2,NQO2,GDF15,ADIPOQ,TGM2,CCL3L1,CCL2,CCL8,CCL3L3,CSF2RA,CST3,STIM1,LBP,ADORA1,GJB2,PLAT,CCR1,C5AR1,CSK,CD69,DEFB1,SLIT2,GRN,SWAP70,S100A9,WAS,LSP1,LYN,FCER1G,PROCR,MAP3K8,PTGS2,SOCS3,ADRBK1,CD36,UNC5B,CXCL12,TGFBR2,RSPO3,IKBKG,PLA2G5,CXCL14,NEO1,C1QBP,CAST,PTX3,CSF3R,CXCL8,SPP1,VEGFC,CAPG,TPSAB1/TPSB2,ITGAM,DUSP1,IGFBP3,CD14,MDK,C2,AOC3,LEP,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,CD55,NFKBIA,CCL13,EDN1,TIMP1,SAA1,CFB,S100A8,ERBB2,MAPKAPK2,AGT,THBS4,VCAM1,NLRP3,NQO1,HYAL1,PLAUR,LRRK2,BTK,VAV3,EDNRA,NCKAP1L,CXCL2,MMP9	113	
Cell Death and Survival	cell death	cell death of lymphoma cell lines	3.06E-08	 	-1.202	 	-1.150	CD4,CXCL12,FCER1A,SERPINA3,IL6,CBX5,SPI1,MYC,CCND3,RARA,HDAC11,CARD8,BIRC3,MCL1,ATG7,ITPR2,TNFRSF10B,BCL2L1,GZMH,HLA-DRB4,RAP1GAP,DUSP1,BTG2,IGFBP3,IDO1,NOTCH1,mir-21,FTH1,RUNX1,CNN2,IGFBP4,ADAM17,DDIT3,ERN1,FGF2,LEPR,BMP2,ABL1,TNFSF10,CASP4,DIABLO,TGM2,CD55,MTOR,NFKBIA,JUN,SMO,CD24,NCL,LONP1,CHEK2,FCER2,NDUFAF4,CD59,MECOM,CXCR4,EGR1,SMAD7,BTK,EBF1,WAS,BMF,LSP1,CAT,LYN,ARHGDIA,SOX9,RPLP0	68	
Cellular Growth and Proliferation, Tissue Development	generation	generation of cells	3.21E-08	Increased	2.815	bias	-1.691	KCNJ2,AXIN1,IL6,CCND3,POMZP3,TSC2,PLXNB2,AMHR2,ETS1,TNFRSF21,HEYL,COMP,DDIT4,TMEM203,CDH5,CTSB,mir-21,COL4A5,GADD45B,EIF4EBP2,GBP1,ADIPOQ,HEXA,FNTA,TIPARP,LLGL1,UCP2,ZNF521,CD69,MESP1,IGF2R,ID3,THNSL2,MYO5A,LYN,PROCR,SOX9,SOCS3,SFMBT1,MICALL2,DPYSL4,HAVCR2,RGCC,ZFPM1,CEP104,MTMR2,TEK,MARCO,CXCL8,ADAMTS1,STK39,MAPK8IP2,RIMS4,FIG4,BCL2L1,H3F3A/H3F3B,NAGLU,PSME4,SYN1,ETV5,PEBP1,SULF1,LOX,ZP3,BMP2,FLRT1,HLA-G,EDN1,ERBB2,THBS4,SRC,G6PD,PLAUR,KIF3B,BTK,RRAS2,SPARC,COL11A1,CXCL2,MAP4K4,RER1,BMP4,SNTA1,TYRO3,MST1,POMC,SGPL1,ITGA3,LGMN,IRX3,RARA,MCL1,RND2,SFRP4,PIK3C2B,NAB1,ATG7,ZC3HC1,HBEGF,CEP89,JUNB,HMGA1,MBD2,ROR1,GAMT,GDPD5,RTN4,CAPRIN1,NOTCH1,ANG,NRP1,CNN2,MAP7,FYN,BTG3,LEPR,EFHD1,SLC1A3,ATAT1,FKBP1A,RUVBL1,MEOX2,ENAH,EIF4EBP1,MAFG,KLF9,JUN,CST3,CSF2RA,DPCD,EGFL6,NPTXR,PRPH,PTPRK,CSK,EGR1,DAAM1,SLIT2,AXL,RELN,DHCR24,SBF1,TENM4,PTGS2,CHD7,ARID4A,TNFRSF4,PFN1,FARP1,CD36,CD4,MAP1B,MNS1,LHCGR,METAP2,WDR5,IKBKG,ETS2,AMPH,GSK3B,GPC1,RET,PTPRE,FST,EGR3,IRX6,ZMYND15,INHBB,FLCN,ATPIF1,PRKCD,UVRAG,--,SFRP2,NGF,PTPRF,NFKBIA,ANGPTL4,THBS1,DUSP10,SMO,FNDC5,SULF2,MAPKAPK2,ADRB2,ZFP42,PAK4,EPAS1,LRRK2,EDF1,PRMT1,NCAPH2,COL1A1,KIF2A,EBF1,PAG1,EPHB3,GAP43,KDR,NCKAP1L,CPEB1,SLIT3,HLA-DOA,MAP6,CACNA1H,SERPINA3,CLSTN2,SPI1,SLC9A1,CLIP1,ODC1,NKAP,EGR2,CYBA,MCOLN3,KIF1A,MGP,CAV1,DLG4,ATF4,EBF2,HIPK2,MAD2L2,C1GALT1C1,FLOT1,LAMC3,SMOC2,IFNAR2,PYGO2,CARD9,LRRN3,BTG2,CD86,ITGA1,SQSTM1,DEAF1,APOE,NME1,SLC4A2,PLXNA3,FGF2,SEMA6A,CDK4,ASB1,CCL2,PLIN2,IL34,TNMD,DAB2,CSNK2B,PIK3R2,HEY1,CCR1,MAPKAP1,ZNF580,CUL7,GFRA2,HSPA2,GRN,FOS,ARHGEF5,PLA2G4A,MYOC,NRXN2,ZFPM2,NR4A2,LDLR,NTRK3,ATP6V0A2,ARHGDIA,BMPER,TP53BP1,MAP3K8,AFG3L2,PIN1,BMP6,MT2A,NCDN,PTTG1,ITGB1BP1,ABCA3,MBP,ABCG1,MYC,TGFBR2,NNMT,HSPA4,RHOB,MAP2K2,HDAC11,GIMAP5,PDCD6,CHTF18,CAST,PDZRN3,PFKFB3,ATF3,MYDGF,RILPL1,DOK2,LAMA2,UNC13B,VEGFC,THRA,ARSA,KLF4,SLC3A2,SDCBP,MATN2,ALDH1A2,HIF1AN,FZD5,MDK,ESR1,TXNRD2,RBP4,RUNX1,FAM107A,CDC20,FRZB,MPZL2,CADPS2,ATF6,CCL3,HNRNPK,ETV6,CIAPIN1,SHC1,RGS5,TIMP1,SAA1,MKL2,ENPP2,LONP1,AGT,GJA4,VCAM1,SLC12A2,NQO1,SMAD6,NUP210L,BSCL2,SH3PXD2A,RCAN1,PMP22,CAPNS1,VAV3,PLEKHA2,DNM1L,APOB,ITSN1,SGK1,MAF,HRAS,RAPH1,ADGRL1,HOXA9,SATB2,MFAP2,CCNB1IP1,VEGFD,DNAJA3,IRS2,TXN,HEY2,RIMS3,CHN1,FANCG,THY1,RPA1,MMP2,TNK2,S1PR3,DOCK1,SRGAP3,CDH2,NR1D1,BSG,PIP5K1C,STIP1,IL10RA,MAP2K3,LRP8,MAPK7,SFRP1,CYR61,PHLPP1,ADM,SPTBN1,ADAM17,MSC,RALA,WASF3,TNFSF10,MYH11,DCLK1,VCAN,UCHL1,EFNB2,ID1,MTOR,CCL3L3,SNX10,CLMN,SOCS2,SLC19A1,PRKCE,STIM1,COL18A1,ADGRB2,PLOD3,PLAT,IL11RA,CYP11A1,MYCN,C5AR1,ADRM1,ANGPT1,TYROBP,CYP1B1,ADGRG2,YBX2,F11R,KRT8,S100A9,WAS,PPP1R16B,ADCY1,FCER1G,S1PR1,DBNL,TAZ,ZFP36L2,SYN2,RUFY3,FZD7,CXCL12,LIPE,SDC4,DYNLT1,CYP26B1,CRIP1,BRSK1,PRND,IP6K1,LTBR,FBXO45,KLF2,RTN4R,ADRA1B,CSF3R,MIF,AXIN2,SPP1,DNASE2,PARN,MYOF,FOXC1,STC1,GSR,ERCC1,PKD1,RGN,GDI1,ADAMTS7,LEP,RNF165,NFIX,EPB41L3,NLGN1,ERN1,FLRT2,VAPA,PKM,ABL1,TNFAIP3,SMPD1,IRF3,HIF1A,PDCD4,PRKCSH,TNFRSF12A,SOX17,HMOX1,TMEM119,FLNA,CLOCK,KIT,MICALL1,NSMF,S100A8,NR2F6,CTDNEP1,MYO16,PTGER4,ACTN1,ASIP,PRNP,CXCR4,AP3D1,SMAD7,F13A1,SCIN,TRIP6,MKNK2,CSF1R,PBX3,LPAR1,EDNRA,ELK1,RTN3,RCAN2,P2RX7,MMP9,CARM1	515	
Cellular Movement	migration	migration of tumor cells	3.27E-08	 	0.277	 	-1.556	CTGF,PTTG1,CXCL12,HRAS,IL6,SATB2,ITGA3,RHOB,CSE1L,LUM,CAV1,VEGFD,SIAH2,IRS2,RET,CLCN3,AHCY,CSF3R,CXCL8,BIRC7,MIF,SELE,SPP1,VEGFC,HBEGF,MMP2,KLF4,CDH2,DUSP1,CTSB,ALCAM,SFRP1,PDGFD,VHL,MAP2K5,S100P,NRP1,SH3BP4,SFRP2,LEP,EMILIN2,ADIPOQ,CCL3,VCAN,RAB5A,NFKBIA,CCL2,TIMP1,THBS1,CSF2RA,MCAM,PRKCE,ENPP2,COL18A1,SOX7,SRC,VCAM1,PAK4,CXCR4,PLAUR,SLIT2,CSF1R,SPRY2,LSP1,LYN,SPARC,PTGS2,KDR,NEDD9,DSG2,MMP9,TM4SF1	72	
Cellular Movement	cell movement	cell movement of cancer cells	3.31E-08	 	0.622	bias	-1.224	CTGF,PTTG1,CXCL12,HRAS,IL6,ITGA3,RHOB,LUM,CAV1,VEGFD,IRS2,CSF3R,CXCL8,SELE,MIF,SPP1,MMP2,KLF4,CDH2,DUSP1,CTSB,ALCAM,SFRP1,VHL,MAP2K5,S100P,NRP1,SFRP2,EMILIN2,CCL3,VCAN,CCL2,CSF2RA,THBS1,MCAM,PRKCE,COL18A1,SRC,PAK4,VCAM1,CXCR4,CSF1R,SPRY2,LSP1,LYN,SPARC,KDR,NEDD9,DSG2,TM4SF1,MMP9	51	
Cell-To-Cell Signaling and Interaction	binding	binding of cells	3.46E-08	 	0.833	 	-1.269	ELANE,CTSG,HRAS,POMC,IL6,NKAP,ITGA3,CAV1,CALCRL,CLEC4G,SELE,C1GALT1C1,THY1,MMP2,THBD,CDH2,COLEC12,CD68,CDH5,STIP1,ALCAM,TFRC,CCT3,CD86,RAMP3,LRP8,ITGA1,CYR61,ADIPOR2,ITGA7,NRP1,SORL1,FYN,APOE,FGF2,LEPR,ACKR2,ADIPOQ,CKAP4,DDX3X,TGM2,JUN,CCL3L1,CCL2,ANXA5,SLC19A1,CD24,LIPG,LBP,COL18A1,FCGR3A/FCGR3B,FCER2,CCR1,CD209,SIGMAR1,ANGPT1,CSK,CD69,PVR,AXL,RELN,IGF2R,F11R,LY96,LDLR,S100A9,LSP1,LYN,S1PR1,ST3GAL4,CD36,CD4,LHCGR,CXCL12,SDC4,HSPA5,GPC3,CCT8,RHOB,PLA2G5,CCT5,SLC7A5,STAB1,GSK3B,GPC1,LTBR,SNU13,C1QBP,RTN4R,GPR1,MARCO,FERMT3,PTX3,ELN,CXCL8,SPP1,LAMA2,ARSA,INHBB,SLC3A2,ITGAM,ADRA2A,ORM1,RAP1GAP,IGFBP3,CD14,AOC3,LOX,SFTPD,LEP,ZP3,SCARA5,ABL1,CCL3,RAMP2,PTPRF,TNFRSF12A,EPHB6,CD55,F8,THBS1,KIT,ERBB2,SEMA3B,NCL,PRNP,AGT,SRC,VCAM1,PARVA,CXCR4,PLAUR,DNAJC1,IL18RAP,CLGN,SCARA3,SPARC,CXCL2,CLEC10A	139	
Energy Production, Lipid Metabolism, Small Molecule Biochemistry	oxidation	oxidation of lipid	3.72E-08	 	-1.143	 	-2.639	PLIN1,AKR1C3,SESN2,CD36,LIPE,POMC,IL6,MYC,TYSND1,POR,NR4A3,ALDH1A1,LPIN1,G0S2,IRS2,HADHA,PDK4,MIF,ACSL3,ATG7,PEX7,THRA,LONP2,ECI1,DHRS9,SLC22A5,ALDH1A2,SLC27A1,ACACA,AKR1C4,ADIPOR2,APOE,LEP,C1QTNF1,ADH1C,ADIPOQ,HIF1A,GCDH,AADAC,MTOR,ALDH1A3,CYGB,ACSL4,LRPPRC,CSNK2B,GOT2,ABCC9,ACADM,ABHD5,EPAS1,UCP2,LCLAT1,CYP27A1,RGS16,DGAT2,SLCO2A1,TK2,CYP1B1,GPAM,NR4A2,ACADVL,IMMT,CAT,NUCB2,PTGS2,AOX1,RDH5,P2RX7,CYP2C8	69	
Cancer, Organismal Injury and Abnormalities	connective or soft tissue tumor	connective or soft tissue tumor	3.79E-08	 	-0.641	 	-0.390	RPE,ASS1,IL6,SLC39A8,POR,TSC2,SMARCB1,AMHR2,SLC2A5,RBM38,NDUFS7,PTPN3,mir-21,FTH1,COL4A5,DDIT3,COL15A1,SLC25A1,IGF2R,LYN,SOCS3,AKR1C3,CTSD,ERAL1,TUBA1C,TEK,CPNE1,KMT5A,H19,ERCC2,TXNRD1,BCL2L1,H3F3A/H3F3B,ADRA2A,NDUFS3,SUN1,LOX,LITAF,SFTPD,COL6A1,EDN1,ERBB2,SRC,THBS4,NLRP3,COL6A2,PLAUR,PYGB,SNX27,CLEC16A,BTK,ACADVL,FECH,SPARC,COL11A1,GSTO2,MAP4K4,PRUNE2,ASPSCR1,BMP4,MST1,ACP5,PPP4C,NR4A3,SP110,LGMN,MTUS1,RARA,PNKD,MED16,CAPN5,SFRP4,CAPN6,KAZALD1,HMGA1,PARP3,AP2S1,ACAD11,RTN4,ME2,AKR1C4,TSPAN6,NOTCH1,COL3A1,NRP1,SUSD2,SORL1,FYN,LEPR,HYOU1,FKBP1A,TRPT1,THBS3,EIF4EBP1,JUN,CD24,COL22A1,FUK,RNF135,ACVR1C,ECM2,BLMH,COL12A1,EGR1,DDX24,RELN,VPS9D1,SBF1,PTGS2,ARID4A,COBLL1,TNFRSF4,FAT1,LHCGR,PIGQ,CNDP2,ALDH1A1,GSK3B,RET,MT1G,HNMT,ACP2,ATP10A,C19orf48,UBXN11,TPSAB1/TPSB2,SLC2A10,COL6A3,RAP1GAP,PRKCD,CLCN7,CRABP2,--,NGF,HINT1,GNG11,ANGPTL4,MARCH8,THBS1,CFB,SMO,STK24,WSB2,CHEK2,ADRB2,COL5A2,PARP10,METTL1,HYAL1,LRRK2,THRSP,COLEC11,COL1A1,NUCB2,GBE1,KDR,SLIT3,MAP6,WBSCR22,CACNA1H,CTSG,COL8A1,SPI1,CYBA,PLEKHO2,CAV1,MTHFD2,HES6,HIPK2,ALDH3A1,TACO1,CASQ2,ALDH1B1,RRP1,PLD3,STK36,DPT,TNFRSF10B,CARMIL1,IFNAR2,GPX7,WDR81,CYP4B1,GALK1,NCF2,PPP1R15A,P2RX6,BYSL,TRAPPC5,ERI3,APOE,NOL7,SLC4A2,PHLDA2,FGF2,GDF15,CDK4,TECR,COL16A1,RNF181,CHDH,SORBS1,SOS1,RENBP,FCGR3A/FCGR3B,ALDH5A1,FCER2,HELZ,TJP1,NINL,GALM,FOS,ZFPM2,MYOC,NR4A2,LDLR,NTRK3,GPBAR1,ATP6V0A2,XAF1,SLC22A18,TP53BP1,ADRA1A,MAOA,MEGF9,PTTG1,PARP2,CLPP,MYC,HSPA4,ZNF598,CXCL14,FMO2,DOK2,LAMA2,VEGFC,ARSA,KCNG1,ABCA8,DUSP1,HIF1AN,IGFBP3,CCPG1,ESR1,DOCK6,TXNRD2,RUNX1,POLR3F,SRPX,FRZB,SCARA5,ATF6,CCL3,SLC2A3,ETV6,SHC1,RPL14,HLA-DRB1,RGS5,TIMP1,LRPPRC,GJA4,TUBG1,GATSL3,NUP210L,ATIC,SLK,CXCL16,LOC102724788/PRODH,TACC2,PIGB,VAV3,CAT,DNM1L,SLC29A4,APOB,DPYD,AHCYL1,MAF,CDKN2C,HRAS,HOXA9,LPIN1,PKIA,TXN,WNT5B,CALCRL,ARHGEF4,NDRG1,SLC24A3,PCSK5,RRBP1,GSTM3,TUBB2A,STOML2,MMP2,UBQLN4,DOCK1,CCND2,PTPRB,MAP3K20,ADAMTS18,ALDOA,HSPB7,RSU1,SFRP1,PDGFD,CYR61,MYEOV,DHRS4,SPTBN1,MME,ALDH4A1,GRB14,UQCRH,TNFSF10,PFKL,VCAN,IDH1,UCHL1,COL5A1,TRIB1,MTOR,ALDH1A3,SLC19A1,PRKCE,TBCD,KIAA0391,COL18A1,PTPRT,SF3A2,PI4KA,DNAH6,MYCN,FMO3,IMPDH2,TYROBP,MGMT,HDC,MVB12A,STXBP6,CYP1B1,MIOS,COL5A3,KRT8,LSP1,NR5A2,CBX4,FBN2,LIPE,CCT8,CEL,TNIP1,ITGA11,SDPR,D2HGDH,TRIM5,ADRA1B,PDK4,CSF3R,MIF,SPP1,PCSK7,LMNA,RPL9,PPP2R1A,ITGAM,SRPK3,PKD1,RRP7A,AK2,COL7A1,CDH23,RBBP8,ABL1,SLC7A1,SMPD1,CDKN2B,RAMP2,COL1A2,CSPG4,RPS6KB2,MICALL1,KIT,ALPL,CUL9,PTGER4,PRNP,FRMD1,DLGAP4,SMAD7,ZBTB7C,CSF1R,FIZ1,ITPA,CYTIP,LRP1B,P2RX7,MMP9,ATP6V1B2,CARM1	401	
Neurological Disease	seizure disorder	seizure disorder	3.81E-08	Decreased	-2.371	bias	-0.085	NNAT,SNTA1,TYRO3,CA5B,CACNA1H,CA12,C1QA,IL6,C1QB,SLC9A1,NR4A3,SLC4A3,EGR2,GLB1,ABCC1,NPTX2,MCL1,PIGT,CALCRL,ATG7,DBP,SV2B,CHN1,PPP1R1B,JUNB,NPY5R,HSPA8,SH3GL1,SLC25A22,MS4A4A,CTSB,ME2,ATOX1,AARS,CYR61,EPHX1,ADM,FYN,APOE,GADD45B,ZFP36,FGF2,GNA11,HYOU1,SLC1A3,MIR22HG,ADIPOQ,CEBPD,HEXA,TGM2,DTNA,TRIB1,CA3,DUSP5,MTOR,JUN,GBA,TIPARP,GADD45A,PNPO,ALDH5A1,ATN1,NAPB,PLAT,CCR1,SIGMAR1,EGR1,RGS16,ANOS1,GFRA2,ST3GAL3,RELN,GABRE,CSTB,FOS,LDLR,RNF144A,SPRY2,ATP1A2,TPP1,DBNL,PTGS2,SYN2,ADRA1A,CYP2C8,CH25H,RGS1,SOCS3,NCDN,CYTOR,CA4,HSPA1A/HSPA1B,MAP1B,TUBB,MYC,CTSD,IKBKG,AMPH,CLCN3,ADRA1B,STXBP1,ATF3,ACP2,CYYR1,IER2,EGR3,UNC13B,FZD9,LMCD1,FOSB,DUSP1,SYN1,TEF,--,GDI1,LEP,NGF,SLC2A3,HMOX1,ANGPTL4,KCNMA1,SRGN,LOC102724428/SIK1,MICALL1,IFRD1,ALPL,CRYM,ADRB2,CXCR4,C9orf3,SLC12A2,PCOLCE2,AP3B2,PLAUR,SERTAD1,SERPINE2,PMP22,ITPA,AP3M2,GAP43,MMP9	141	
Carbohydrate Metabolism	metabolism	metabolism of polysaccharide	3.92E-08	 	-1.720	 	-3.281	NNAT,SOCS3,GFPT1,CTGF,ADRBK1,SGSH,CD36,HRAS,IL6,GUSB,IDUA,PPP1R3F,GYS1,CCND3,GAA,IRS2,GSK3B,GPC1,LYVE1,ADRA1B,PHKG1,SPP1,APLNR,H6PD,VEGFC,MMP2,THBD,FOXC1,NR1D1,BSG,IGFBP3,CTSB,NAGLU,SFRP1,B3GAT3,SULF1,APOE,B3GALT6,LEP,LEPR,FGF2,BMP2,PPP1R3C,CHPF,HS2ST1,ADIPOQ,PPP1CB,HEXA,INPPL1,B4GALT7,MTOR,EDN1,SORBS1,PDE3B,ERBB2,SULF2,STK40,ACADM,PTGER4,ADRB2,PLAT,AGT,ABHD5,ANGPT1,HYAL1,PYGB,AGL,CSF1R,GPAM,XYLT2,ZFPM2,NTRK3,GBE1,COL11A1,NDST2	75	
Cardiovascular System Development and Function, Tissue Development	tubulation	tubulation of endothelial tissue	3.96E-08	 	-0.523	 	-2.017	LEP,GBP1,FGF2,ADIPOQ,CXCL12,IL6,NEU1,EFNB2,ESAM,ID1,ANGPTL4,RHOB,EDN1,FLNA,KCNMA1,SAA1,MGP,CAV1,STIM1,SEMA3B,MAPKAPK2,NCKIPSD,TEK,FERMT3,SRC,CXCL8,ANGPT1,G6PD,THY1,VEGFC,PLAUR,MMP2,SLIT2,AXL,ID3,RCAN1,F11R,COL1A1,IGFBP3,ALCAM,CYR61,KDR,NOTCH1	43	
Metabolic Disease	amyloidosis	amyloidosis	4.01E-08	 	-1.316	 	-0.624	CTGF,TGFBR3,RAN,NCSTN,SERPINA3,IL6,ADGRL1,EEF1G,LGMN,SPTLC2,CAV1,ATF4,LSS,TXN,UNG,TSHZ2,PLD3,OSBPL10,THY1,LARP4,MMP2,CHI3L2,HMGA1,CRABP1,CD68,PSMB2,MS4A4A,STIP1,CTSB,GAPDH,LRP8,PLTP,NOTCH1,MME,SORL1,APOE,DDIT3,FGF2,CDK4,SLC1A3,CASP4,MEOX2,MYH11,EIF4EBP1,C1R,UCHL1,SPON1,TGM2,DTNA,LYZ,MTOR,JUN,CCL2,CST3,PDE3B,PRKCE,LDLRAP1,FCGR3A/FCGR3B,ALDH5A1,PLAT,CYP11A1,CTSK,BLMH,TYROBP,APBB3,SLCO2A1,RELN,ACLY,GABRE,PLA2G2A,HP,LDLR,TF,CBS/CBSL,DHCR24,S100A9,NTRK3,LIMS1,CNN1,TAGLN,PTGS2,BMP6,ADRA1A,MAOA,QPCT,CH25H,CD36,HSPA1A/HSPA1B,CLEC3B,CXCL12,HSPA5,TUBB,BIN1,TGFBR2,CTSD,ETS2,AMPH,NAV1,GSK3B,CAST,RET,RTN4R,ADRA1B,IGFBP6,CXCL8,NBAS,PSMB5,GM2A,MACROD1,HSPA9,PAWR,PTGDS,EPRS,OGN,ADRA2A,PRKCD,SLC7A2,IGFBP3,NAGLU,CD14,ESR1,DOK5,LEP,FEM1A,SMPD1,CADPS2,HIF1A,NGF,CCL3,GLRX,SLC2A3,HMOX1,ALDH2,DHCR7,STUB1,TIMP1,BCYRN1,SAA1,C7,CFB,IGSF8,HMGCL,PTGER4,ADRB2,PRNP,AGT,FAAH,CXCR4,NQO1,CANX,SERPINE2,CXCL16,RCAN1,TMEM2,LRP1B,APOC1,SPARC,GAP43,GAPVD1,DNM1L,RTN3,MMP9	162	
Carbohydrate Metabolism	synthesis	synthesis of carbohydrate	4.02E-08	 	1.092	bias	-1.215	NNAT,GFPT1,PLIN1,CTGF,GMDS,VAC14,HRAS,SH3GLB1,POMC,IL6,NR4A3,PPP1R3F,GYS1,GNA15,CCND3,ATF4,IRS2,PIK3C2B,GRK5,SERINC1,THBD,S1PR3,SERINC2,AQP9,NR1D1,BSG,PIP5K1C,PPP1R15A,GAPDH,ITGA1,SLC27A1,SFRP1,B3GAT3,APOE,SCAP,RALA,PIGO,FGF2,LEPR,PPP1R3C,HS2ST1,DPM2,ADIPOQ,HEXA,B4GALT7,MTOR,CCL2,SORBS1,ADORA1,PI4KA,TSTA3,ABHD5,ANGPT1,DGAT2,DPAGT1,PTDSS2,GPAM,ZFPM2,NR4A2,NTRK3,LYN,S1PR1,MAN2B1,NDST2,ADRA1A,SOCS3,GNPDA1,PIGU,ADRBK1,CD36,LHCGR,LIPE,PIGQ,MYC,PGD,ALDH1A1,PCYT2,PGP,GOT1,MTMR2,GSK3B,GPC1,ADRA1B,CXCL8,MIF,SPP1,APLNR,GNG2,H6PD,VEGFC,GPAA1,SORD,ACBD6,IGFBP3,RGN,EXTL3,AKR1B1,VHL,GMPPB,PTGFR,B3GALT6,LEP,BMP2,CHPF,PPP1CB,ATF6,INPPL1,NGF,EDN1,KIT,ENPP2,ERBB2,ACADM,PTGER4,PI4KB,ADRB2,AGT,G6PD,HYAL1,GNAI1,CSF1R,XYLT2,PIGB,GBE1,GAPVD1,PNPLA6	126	
Cardiovascular Disease	peripheral arterial disease	peripheral arterial disease	4.35E-08	 	 	 	 	SGK1,DNAJB4,CD36,HSPA1A/HSPA1B,CXCL12,VWA5A,CD163,CAAP1,HSPA4,EGR2,AMPH,PLEKHO2,SLCO2B1,GULP1,SPP1,FAHD2A,THY1,CAPG,KLF4,RPL9,NGRN,LMCD1,CTSA,NPR3,BTG2,CTSB,EBNA1BP2,PLTP,CCL18,FTH1,RUNX1,APOE,HSD17B11,PPP1CB,ADAP2,GLRX,SLC2A3,COL1A2,SUCLA2,HLA-DRB1,COL6A1,THBS1,SNX10,LOC102724428/SIK1,DAB2,STK24,SEMA3B,FCGR3A/FCGR3B,PTGER4,ADRB2,CCR1,UCP2,C5AR1,CXCR4,VSIG4,PLAUR,RUFY1,COL1A1,PLA2G4A,NR4A2,LPAR1,CYTIP,LYN,TPP1,PTGS2,NEDD9,MAP4K4,KTN1	68	
Neurological Disease	chorea	chorea	4.40E-08	 	 	 	 	CTGF,AHCYL1,SGK1,CA12,ZNF239,HRAS,PCDH7,GHITM,SERPINA3,IL6,ATP2A2,MT1E,EGR2,GPRC5C,PPRC1,TXN,PKIA,CASQ2,AHCY,POLR2I,FBL,CDKN1C,NDRG1,COCH,DBP,CHN1,PPP1R1B,MT1X,PTPN3,JUNB,IER3,NGRN,HSPA8,MAP3K12,CDH2,PDLIM7,NR1D1,CD68,PDE1B,GAPDH,SLC27A1,EIF3K,SORL1,APOE,NME1,NDUFA7,DDIT3,GBP1,SRD5A1,FGF2,SCUBE2,SLC1A3,KAZN,THBS3,CORO2B,VCAN,UCHL1,TGM2,DTNA,DUSP5,STOM,JUN,MAL2,GADD45A,CYP51A1,MYOM2,MLF2,EGR1,NBEA,SLIT2,PSMB6,ID3,GABRE,MYO5A,FOS,F11R,GPAM,HP,LAMP2,LDLR,UQCR10,S1PR1,FKBP4,SOX9,ID4,ADRA1A,MT2A,SERPINI1,PFN1,PFKFB1,ATP2B1,HSPA1A/HSPA1B,MT1M,DNAJB2,SDC4,DYNLT1,HSPA5,FAM173A,CYP26B1,AK1,STRN4,KCNAB1,ADRA1B,RASGRP2,MT1G,APLNR,ICA1,LMCD1,BCL2L1,ITGAM,RAP1GAP,C2orf40,RARRES3,IDO1,NDUFS3,ETV5,RBP4,SRM,FAM107A,SH3BP4,LEP,SLC1A4,SRPX,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,EMX2,GTF3A,NGF,ALDH2,HMOX1,RAB5A,AEBP1,DHCR7,HINT1,SUCLA2,DKK3,MT1L,C7,MICALL1,CRYM,ACADM,ADRB2,PSAT1,SMAD6,DAAM2,SGTA,PLSCR4,NDUFA13,RCAN1,PMP22,KCTD13,CAPNS1,VAMP1,CYC1,ACAT1,UQCRC1,NREP,XK,ATP6V1B2	162	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	advanced malignant solid tumor	4.54E-08	 	-0.081	 	-0.555	DPYD,CTGF,KCNJ2,TGFBR3,CMTM4,HRAS,CDKN2C,GYG2,ACP5,IL6,HOXA9,PCOLCE,POR,PLS3,CSE1L,CAV1,NDRG1,MFAP5,GSTM3,TNFRSF10B,TUBB2A,MMP2,PARP3,TNK2,IFNAR2,TFPI2,HAX1,CDH2,ISLR,COLEC12,CCND2,TRO,GLUL,LRP8,SFRP1,mir-21,MME,HIST2H2AA3/HIST2H2AA4,MSC,ZFP36,GSTM5,TCEA1,NID2,SRD5A1,FGF2,GDF15,CEBPD,CDK4,FKBP1A,COL15A1,VCAN,C1R,DTNA,MTOR,KAT2B,CCL2,CMTM8,PRKCE,CD24,DAB2,TRIM29,COL18A1,CYP51A1,FCGR3A/FCGR3B,PLAT,SLC12A8,MECOM,EPB41L4B,OLFML3,SLIT2,AXL,POLD1,ZFPM2,PTGS2,SEMA3C,ABCC3,ZFP36L2,TM4SF1,QPCT,FZD7,FBN2,AKR1C3,CD36,PTTG1,RTN1,PARP2,KLF6,RGCC,LHCGR,CXCL12,RNASE1,DNAJB2,TUBB,TGFBR2,MAP2K2,DHTKD1,TUBA1C,RET,PDZRN3,CLCN3,TEK,PTX3,CXCL8,SPP1,FST,ADAMTS1,VEGFC,CAPG,ERCC2,KLF4,GSR,EFS,BCL2L1,PPP2R1A,ABCA8,ERCC1,COL6A3,ALDH1A2,SCRIB,LSM7,DNAJB6,CRABP2,ESR1,ERAP2,IGFBP4,SRPX,EPB41L3,FLRT2,ABL1,EMX2,HIF1A,GLRX,GSTT1,EPHB6,HMOX1,EDN1,THBS1,FLNA,KCNMA1,MCAM,SMO,LOC102724428/SIK1,KIT,RNH1,ENPP2,ERBB2,RNF144B,ALPL,PRNP,SRC,VCAM1,CXCR4,TUBG1,PLAUR,PLSCR4,CPA4,CSF1R,ATIC,EMP1,C2orf88,NEK11,CLGN,VAV3,CAT,LPAR5,ING1,KDR,DSG2,MMP9	169	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	progression	progression of tumor	4.59E-08	 	1.319	 	0.563	CXCL12,IL6,MYC,TGFBR2,PLCE1,CXCL14,CAV1,STAB1,CXCL8,IGFBP6,MIF,SPP1,DDT,TNK2,THBD,FOXC1,BSG,ALCAM,ESR1,mir-21,PHLPP1,NRP1,IGFBP4,APOE,LEP,FGF2,GDF15,CDK4,TNFSF10,HIF1A,PDCD4,COL1A2,NFKBIA,JUN,EDN1,TIMP1,MCAM,ERBB2,FCGR3A/FCGR3B,SRC,MYCN,CTSK,CXCR4,PLAUR,BRMS1,AXL,COL1A1,FOS,ANXA3,CAT,FCER1G,PTGS2,COL11A1,NEDD9,MMP9	55	
Cardiovascular Disease, Organismal Injury and Abnormalities	formation	formation of vascular lesion	4.74E-08	 	-1.210	 	-1.177	RUNX1,APOE,LOX,APOB,LEP,PFN1,ZFP36,PLA2G15,IL6,MYC,HMOX1,SHC1,IKBKG,NFKBIA,CCL2,CCL3L3,TIMP1,CST3,MGP,MKL2,LIPG,KLF2,AGT,CCR1,ELN,VCAM1,CD59,SPP1,PCSK5,MMP2,SGCB,THBD,COL1A1,LDLR,CBS/CBSL,PTGS2,CXCL2,ESR1,EFEMP2,VHL,MMP9	41	
Neurological Disease	epileptic seizure	epileptic seizure	4.90E-08	 	-1.633	 	-1.026	CH25H,RGS1,SOCS3,CYTOR,NCDN,HSPA1A/HSPA1B,SNTA1,TYRO3,C1QB,SLC9A1,NR4A3,IKBKG,EGR2,NPTX2,MCL1,CALCRL,ATF3,IER2,EGR3,JUNB,LMCD1,FOSB,HSPA8,DUSP1,CYR61,ADM,GADD45B,ZFP36,MIR22HG,CEBPD,SLC2A3,HMOX1,TRIB1,DTNA,DUSP5,ANGPTL4,JUN,GADD45A,TIPARP,SRGN,IFRD1,CRYM,CCR1,CXCR4,C9orf3,EGR1,ANOS1,RGS16,SERTAD1,GABRE,CSTB,FOS,LDLR,SPRY2,AP3M2,PTGS2	56	
Cancer, Organismal Injury and Abnormalities	neuroepithelial tumor	neuroepithelial tumor	5.08E-08	 	-0.023	 	-0.400	ASCC2,IL6,ATP2A2,CLIP1,AJUBA,MCOLN3,LUM,MGP,CAV1,HES6,HIPK2,SLCO2B1,TSHZ2,WASH3P,ALDOC,SELE,LHPP,COCH,TNFRSF10B,TFPI2,PYGO2,HSPA8,DVL2,ALCAM,mir-21,ZDHHC4,CD163L1,GBP1,FGF2,GDF15,CDK4,DTNA,RAD21,CYP51A1,MECOM,ID3,HSPA2,GRN,KIF7,LDLR,NTRK3,FLNC,TAGLN,SOX9,BMP6,ABCC3,KTN1,RARRES2,MBP,PTTG1,KLF6,DIRAS1,HSPA5,BIN1,GPNMB,MYC,TGFBR2,KCNAB1,FAR2,RPAP1,TEK,PFKFB3,H19,PTGDS,BCL2L1,ABCA8,H3F3A/H3F3B,DBNDD1,BUD31,BAP1,AGAP3,ESR1,VHL,RAB11FIP5,FEM1A,DENND4B,DCAF4,GIMAP6,HLA-G,MSRB3,COL6A1,TIMP1,ENPP2,ERBB2,CIZ1,SRC,VCAM1,NLRP3,SLC12A2,NUP210L,CXCL16,VAV3,CAT,SPARC,COL11A1,MAP4K4,ITSN1,CA12,HRAS,CDKN2C,RAPH1,RNF38,PRG4,MGAT4B,ANK2,ALPK1,CAPN5,PIK3C2B,SV2B,PLEC,HBEGF,GRK5,MBD2,TNK2,DOCK1,CCND2,MS4A7,RSU1,SFRP1,NOTCH1,COL3A1,NRP1,SPTBN1,AKAP12,HIST2H2AA3/HIST2H2AA4,HIST1H1C,MAP7,GSTM5,HYOU1,TNFSF10,FKBP1A,H2AFZ,IDH1,MTOR,TARS2,CSF2RA,PRKCE,COL22A1,MYO1D,PCBP2,AHNAK2,DNAH6,PTK7,CD209,PLXNA1,SLC25A13,ANGPT1,IMPDH2,MGMT,NBEA,SLIT2,RELN,EMC1,COL5A3,RHPN2,S100A9,TF,SBF1,BMF,AOX1,PTGS2,TAZ,SPNS1,SERPINI1,SPHK2,TMEM147,CXCL12,ZNF91,COBL,DHTKD1,TMEM156,CYP4X1,KPNA2,GOT1,GSK3B,RET,TRIM5,PTX3,CSF3R,AXIN2,SPP1,TRIOBP,EGR3,ALAD,GSR,PPP2R1A,PRKCD,CLCN7,ADAMTS7,PA2G4,ATF5,FLRT2,BCL2L12,PKM,ABL1,HIF1A,IRF3,CDKN2B,COL1A2,SOX17,EPHB6,FLNA,DKK3,KCNMA1,THBS1,CSPG4,KIT,CYGB,NR2F6,CHEK2,ACTN1,ZFP42,BEX2,SNAPC4,CXCR4,CPED1,LRRK2,RAPGEF5,CSF1R,ANO2,SYBU,COL1A1,LPAR1,GAP43,C6,ELK1,KDR,MMP9	228	
Organismal Injury and Abnormalities, Tissue Morphology	size	size of lesion	5.24E-08	 	-1.683	 	-1.534	SOCS3,APOB,SERPINI1,ACAT2,SESN2,CD4,CXCL12,SH3GLB1,LIPE,C1QA,ARG2,IL6,TGFBR2,GPX3,CEL,PLA2G5,TSC2,MGP,CAV1,SIAH2,TXN,GSK3B,UNG,PTX3,NOX4,MIF,SELE,SPP1,MYDGF,PTGDS,THBD,NOL3,ITGAM,MDK,APOE,LEP,FGF2,PPP1R1A,GDF15,ADIPOQ,TNFSF10,TNFAIP3,HIF1A,NGF,TNFRSF12A,TGM2,HMOX1,SHC1,CES1,NFKBIA,TIMP1,CST3,ANXA5,RPS6KB2,SLC19A1,PRKCE,ABCC9,COL18A1,MAPKAPK2,PLAT,IL11RA,PRNP,AGT,SRC,VCAM1,RNLS,UCP2,EGR1,GRN,RCAN1,PLA2G4A,LDLR,CBS/CBSL,FCER1G,ACAT1,PTGS2,P2RX7,MMP9,CYP2C8,MAOA	80	
Tissue Morphology	morphology	morphology of connective tissue	5.33E-08	 	 	 	 	PLIN1,CTGF,TGFBR3,CACNA1H,HRAS,NCSTN,EIF6,SPI1,PCOLCE,MIA,IDUA,SATB2,LGMN,MKX,RARA,LUM,MGP,CAV1,VEGFD,AMHR2,PTGIS,RBM38,CIDEC,MMP2,HMGA1,CDH2,MN1,CD68,CDH5,NPR3,EPB42,PPP1R15A,TFRC,MAPK7,PTPRA,NOTCH1,HIST1H1C,APOE,SLC4A2,LTBP2,ZFP36,FGF2,SIN3B,ADIPOQ,CDK4,CEBPD,EFNB2,TRIB1,MCOLN1,PDE3B,CST3,PLIN2,TNMD,CTSK,MECOM,TYROBP,COL12A1,TK2,LDLR,CBS/CBSL,SPRY2,LYN,BNIP3L,BMPER,MAN2B1,SOX9,LIG1,CD36,PTTG1,CLEC3B,LHCGR,LIPE,TPM1,ABCG1,PNRC2,MYC,TGFBR2,RSPO3,CYP26B1,IKBKG,ITGA11,OSR1,AMPH,CLCN3,BIRC3,KLF2,ADRA1B,TEK,PDK4,EIF2AK1,ELN,SLC4A7,THRA,ANO1,BCL2L1,PKD1,IGFBP3,CLCN7,ESR1,LOX,IGFBP4,SFTPD,NFIX,FLRT2,TPR,ANTXR1,ABL1,SLC7A1,HIF1A,ETV6,CIAPIN1,SHC1,AEBP1,CSPG4,THBS1,SMO,ALPL,ACADM,ADRB2,SRC,VCAM1,COL5A2,SLC12A2,HYAL1,BSCL2,KIF3B,CSF1R,COL1A1,ACADVL,VAV3,SPARC,NCKAP1L,EFEMP2	133	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of macrophages	5.58E-08	 	-1.360	bias	-2.778	CNN2,APOE,APOB,PLGRKT,CD36,ADIPOQ,CXCL12,IRF3,CCL3,GPC3,NFKBIA,RHOB,CCL2,THBS1,HCAR2,AGT,FCER2,CCR1,ETS1,CXCL8,VCAM1,CMKLR1,UCP2,SPP1,C5AR1,COCH,MMP28,CSF1R,ITGAM,LSP1,LYN,S1PR1,IDO1,MAP3K8,MDK,CYR61,KDR,NOTCH1,MMP9	39	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders	Huntington's disease	Huntington's Disease	5.63E-08	 	 	 	 	CTGF,AHCYL1,SGK1,CA12,ZNF239,HRAS,PCDH7,GHITM,SERPINA3,IL6,ATP2A2,MT1E,EGR2,GPRC5C,PPRC1,TXN,PKIA,CASQ2,AHCY,POLR2I,FBL,CDKN1C,NDRG1,COCH,DBP,CHN1,PPP1R1B,MT1X,PTPN3,JUNB,IER3,NGRN,HSPA8,MAP3K12,CDH2,PDLIM7,NR1D1,CD68,PDE1B,GAPDH,SLC27A1,EIF3K,SORL1,APOE,NME1,NDUFA7,DDIT3,GBP1,SRD5A1,FGF2,SCUBE2,SLC1A3,KAZN,THBS3,CORO2B,VCAN,UCHL1,TGM2,DTNA,DUSP5,STOM,JUN,MAL2,GADD45A,CYP51A1,MYOM2,MLF2,EGR1,NBEA,SLIT2,PSMB6,ID3,GABRE,MYO5A,FOS,F11R,GPAM,HP,LAMP2,LDLR,UQCR10,S1PR1,FKBP4,SOX9,ID4,ADRA1A,MT2A,SERPINI1,PFN1,PFKFB1,ATP2B1,HSPA1A/HSPA1B,MT1M,DNAJB2,SDC4,DYNLT1,HSPA5,FAM173A,CYP26B1,AK1,STRN4,KCNAB1,ADRA1B,RASGRP2,MT1G,APLNR,ICA1,LMCD1,BCL2L1,ITGAM,RAP1GAP,C2orf40,RARRES3,IDO1,NDUFS3,ETV5,RBP4,SRM,FAM107A,SH3BP4,LEP,SLC1A4,SRPX,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,EMX2,GTF3A,NGF,ALDH2,HMOX1,RAB5A,AEBP1,DHCR7,HINT1,SUCLA2,DKK3,MT1L,C7,MICALL1,CRYM,ACADM,ADRB2,PSAT1,SMAD6,DAAM2,SGTA,PLSCR4,NDUFA13,RCAN1,PMP22,KCTD13,CAPNS1,VAMP1,CYC1,ACAT1,UQCRC1,NREP,ATP6V1B2	161	
Cellular Movement	transmigration	transmigration of cells	5.64E-08	 	0.566	bias	-1.254	RARRES2,CXCL12,ELANE,HRAS,IL6,STAB1,SIAH2,FERMT3,ELN,CXCL8,SELE,SPP1,THY1,NINJ1,STC1,ITGAM,CDH5,RAP1GAP,RTN4,CD86,ALCAM,CAPN2,NOTCH1,AOC3,CNN2,APOE,ADAM17,GDF15,ABL1,MYLK,CCL3,ENAH,TGM2,EFNB2,SHC1,ID1,MTOR,CCL2,CCL3L3,MCAM,ENPP2,ADORA1,CCR1,CD209,SRC,VCAM1,CXCR4,PVR,ID3,COL1A1,F11R,LDLR,VAV3,CXCL2,MMP9	55	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	gliomatosis	gliomatosis	6.24E-08	 	-0.023	 	-0.445	ASCC2,IL6,ATP2A2,CLIP1,AJUBA,MCOLN3,LUM,MGP,CAV1,HES6,HIPK2,SLCO2B1,TSHZ2,WASH3P,ALDOC,SELE,LHPP,COCH,TNFRSF10B,TFPI2,PYGO2,HSPA8,DVL2,ALCAM,mir-21,ZDHHC4,CD163L1,GBP1,FGF2,GDF15,CDK4,DTNA,RAD21,MECOM,ID3,HSPA2,GRN,KIF7,LDLR,NTRK3,FLNC,TAGLN,SOX9,BMP6,ABCC3,KTN1,RARRES2,MBP,PTTG1,KLF6,DIRAS1,HSPA5,BIN1,GPNMB,MYC,TGFBR2,KCNAB1,FAR2,RPAP1,TEK,PFKFB3,H19,PTGDS,BCL2L1,ABCA8,H3F3A/H3F3B,DBNDD1,BUD31,BAP1,AGAP3,ESR1,RAB11FIP5,FEM1A,DENND4B,DCAF4,GIMAP6,HLA-G,MSRB3,COL6A1,TIMP1,ENPP2,ERBB2,CIZ1,SRC,VCAM1,NLRP3,SLC12A2,NUP210L,CXCL16,VAV3,CAT,SPARC,COL11A1,MAP4K4,ITSN1,CA12,HRAS,CDKN2C,RAPH1,RNF38,PRG4,MGAT4B,ANK2,ALPK1,CAPN5,PIK3C2B,SV2B,PLEC,HBEGF,GRK5,TNK2,MBD2,DOCK1,CCND2,MS4A7,RSU1,SFRP1,NOTCH1,COL3A1,NRP1,SPTBN1,AKAP12,HIST2H2AA3/HIST2H2AA4,HIST1H1C,MAP7,GSTM5,HYOU1,TNFSF10,FKBP1A,H2AFZ,IDH1,MTOR,TARS2,CSF2RA,PRKCE,COL22A1,MYO1D,PCBP2,AHNAK2,DNAH6,PTK7,CD209,PLXNA1,SLC25A13,ANGPT1,IMPDH2,MGMT,NBEA,SLIT2,RELN,EMC1,COL5A3,RHPN2,S100A9,TF,SBF1,BMF,AOX1,PTGS2,TAZ,SPNS1,SERPINI1,SPHK2,TMEM147,CXCL12,ZNF91,COBL,DHTKD1,TMEM156,CYP4X1,KPNA2,GOT1,GSK3B,RET,TRIM5,PTX3,CSF3R,AXIN2,SPP1,TRIOBP,EGR3,ALAD,GSR,PPP2R1A,PRKCD,CLCN7,ADAMTS7,PA2G4,ATF5,FLRT2,BCL2L12,PKM,ABL1,HIF1A,IRF3,CDKN2B,COL1A2,SOX17,EPHB6,FLNA,DKK3,KCNMA1,THBS1,CSPG4,KIT,CYGB,NR2F6,CHEK2,ACTN1,ZFP42,BEX2,SNAPC4,CXCR4,CPED1,LRRK2,RAPGEF5,CSF1R,ANO2,SYBU,COL1A1,LPAR1,GAP43,C6,ELK1,KDR,MMP9	226	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development	cell proliferation	cell proliferation of fibroblasts	6.37E-08	 	-0.231	 	-2.154	CBX7,BMP4,CTGF,NCSTN,CDKN2C,HRAS,IL6,SGPL1,CCND3,RARA,LUM,TSC2,SMARCB1,CAV1,ATF4,TXN,NDRG1,TNFRSF10B,DKC1,HBEGF,MMP2,TNK2,CCND2,NPR3,CTSB,ITGA1,MAP2K3,SFRP1,PDGFD,FTH1,FGF2,ADIPOQ,CDK4,TNFSF10,VCAN,B4GALT7,JUN,CCL2,GADD45A,HGS,PLAT,MYCN,GRN,FOS,S100A9,SPRY2,LIG1,SOCS3,PTTG1,TPM1,MYC,TGFBR2,CTSD,PLCE1,NUPR1,ELN,MIF,ATF3,LMNA,FOXC1,FOSB,TLN2,DUSP1,IGFBP3,GNL3,RCE1,ESR1,TXNRD2,VHL,TNFAIP8,IGFBP4,SULF1,PA2G4,BMP2,TPR,ABL1,SMPD1,HIF1A,NGF,CDKN2B,HDGF,HMOX1,AEBP1,HINT1,NFKBIA,EDN1,DKK3,TIMP1,SMO,ERBB2,SULF2,AGT,SRC,PARP10,SMAD7,EMD,PLAUR,SERTAD1,PSME3,CSF1R,LPAR1,SPARC,EDNRA,DNM1L,DSG2,MMP9	106	
Metabolic Disease, Neurological Disease, Psychological Disorders	Alzheimer's disease	Alzheimer's disease	7.12E-08	 	 	 	 	CTGF,TGFBR3,RAN,NCSTN,SERPINA3,IL6,ADGRL1,EEF1G,LGMN,SPTLC2,CAV1,ATF4,LSS,TXN,UNG,TSHZ2,PLD3,OSBPL10,THY1,LARP4,MMP2,CHI3L2,HMGA1,CRABP1,CD68,MS4A4A,STIP1,CTSB,GAPDH,LRP8,PLTP,NOTCH1,MME,SORL1,APOE,DDIT3,FGF2,CDK4,SLC1A3,CASP4,MYH11,MEOX2,EIF4EBP1,C1R,UCHL1,SPON1,TGM2,DTNA,MTOR,JUN,CCL2,CST3,PDE3B,PRKCE,LDLRAP1,FCGR3A/FCGR3B,ALDH5A1,PLAT,CYP11A1,BLMH,TYROBP,APBB3,SLCO2A1,ACLY,RELN,GABRE,PLA2G2A,HP,LDLR,TF,CBS/CBSL,DHCR24,S100A9,NTRK3,LIMS1,CNN1,TAGLN,PTGS2,BMP6,ADRA1A,MAOA,QPCT,CH25H,CD36,HSPA1A/HSPA1B,CLEC3B,CXCL12,HSPA5,TUBB,BIN1,TGFBR2,CTSD,ETS2,AMPH,NAV1,GSK3B,RTN4R,ADRA1B,IGFBP6,CXCL8,NBAS,MACROD1,GM2A,HSPA9,PAWR,PTGDS,EPRS,OGN,ADRA2A,PRKCD,SLC7A2,IGFBP3,CD14,ESR1,DOK5,LEP,FEM1A,SMPD1,CADPS2,HIF1A,NGF,CCL3,GLRX,SLC2A3,HMOX1,ALDH2,DHCR7,STUB1,TIMP1,BCYRN1,C7,CFB,IGSF8,HMGCL,PTGER4,ADRB2,PRNP,AGT,FAAH,CXCR4,NQO1,CANX,SERPINE2,CXCL16,RCAN1,TMEM2,LRP1B,APOC1,SPARC,GAP43,GAPVD1,DNM1L,RTN3,MMP9	154	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	apoptosis	apoptosis of tumor cells	7.16E-08	 	-0.069	 	0.239	PHLDA1,SOCS3,SGK1,CXCL12,HRAS,TPM1,IL6,SPI1,MYC,TGFBR2,RHOB,CCND3,RARA,KEAP1,CAV1,TXN,GSK3B,HIPK2,MCL1,ETS1,TNFRSF21,BIRC7,MIF,CAPN6,NDRG1,TNFRSF10B,HBEGF,VEGFC,PAWR,BCL2L1,TIMP4,BSG,PRKCD,RTN4,IGFBP3,CTSB,ITGA1,MAPK7,NOTCH1,mir-21,VHL,MAP2K5,NRP1,RUNX1,LEP,DDIT3,LEPR,FGF2,GDF15,ABL1,ADIPOQ,TNFSF10,HIF1A,NGF,DIABLO,TRIB1,MTOR,NFKBIA,JUN,GADD45A,TIMP1,KIT,CD24,PRKCE,ERBB2,SEMA3B,COL18A1,BEX2,CD59,PLAUR,BRMS1,TNFRSF14,BTK,ENO1,NR4A2,MCM2,TF,LPAR1,SPRY2,CAT,PROCR,EDNRA,SPARC,TSC22D1,PIN1,KDR,MMP9	87	
Neurological Disease, Psychological Disorders	tauopathy	tauopathy	7.20E-08	 	0.667	 	0.351	CTGF,TGFBR3,RAN,NCSTN,SERPINA3,IL6,ADGRL1,EEF1G,LGMN,SPTLC2,CAV1,ATF4,LSS,TXN,UNG,TSHZ2,PLD3,TUBB2A,OSBPL10,THY1,LARP4,MMP2,CHI3L2,HMGA1,CRABP1,CD68,MS4A4A,STIP1,CTSB,GAPDH,LRP8,PLTP,NOTCH1,MME,SORL1,APOE,DDIT3,FGF2,CDK4,SLC1A3,CASP4,MEOX2,MYH11,EIF4EBP1,C1R,UCHL1,SPON1,TGM2,DTNA,MTOR,JUN,CCL2,CST3,PDE3B,PRKCE,LDLRAP1,FCGR3A/FCGR3B,ALDH5A1,PLAT,CYP11A1,BLMH,TYROBP,APBB3,SLCO2A1,RELN,ACLY,GABRE,PLA2G2A,HP,NR4A2,LDLR,TF,CBS/CBSL,DHCR24,S100A9,NTRK3,LIMS1,CNN1,TAGLN,PTGS2,PIN1,BMP6,ADRA1A,MAOA,QPCT,CH25H,CD36,HSPA1A/HSPA1B,CLEC3B,CXCL12,HSPA5,TUBB,BIN1,TGFBR2,CTSD,ETS2,AMPH,NAV1,TUBA1C,GSK3B,RTN4R,ADRA1B,IGFBP6,CXCL8,NBAS,MACROD1,GM2A,HSPA9,PAWR,PTGDS,EPRS,OGN,ADRA2A,PRKCD,SLC7A2,IGFBP3,CD14,ESR1,DOK5,LEP,FEM1A,SLC1A4,SMPD1,CADPS2,HIF1A,NGF,CCL3,GLRX,SLC2A3,HMOX1,ALDH2,DHCR7,STUB1,TIMP1,BCYRN1,C7,CFB,IGSF8,HMGCL,PTGER4,ADRB2,PRNP,AGT,FAAH,CXCR4,TUBG1,NQO1,CANX,SERPINE2,CXCL16,RCAN1,TMEM2,LRP1B,APOC1,SPARC,GAP43,GAPVD1,DNM1L,RTN3,MMP9	160	
Cell Death and Survival	cell death	neuronal cell death	7.23E-08	 	-0.530	 	-0.300	KCND2,CTGF,BMP4,ITSN1,SGK1,TYRO3,VAC14,HRAS,SH3GLB1,SERPINA3,IL6,SLC9A1,NR4A3,SGPL1,LGMN,CYBA,RARA,KIF1A,TSC2,ATF4,DLG4,HIPK2,UNG,PIGT,TNFRSF21,ATG7,SURF1,MAD2L2,HBEGF,JUNB,HAX1,MAP3K12,CDH2,NR1D1,STIP1,BTG2,NCF2,CTSB,GAPDH,MAP2K3,ITGA1,AARS,MAPK7,CAPRIN1,TMEM158,NRP1,APOE,FYN,DDIT3,GSTM5,FGF2,GDF15,CDK4,HYOU1,SLC1A3,TNFSF10,FKBP1A,MEOX2,VTI1B,DIABLO,UCHL1,TGM2,EFNB2,MTOR,JUN,GBA,CCL2,CCL3L3,RASSF5,ADORA1,GJB2,ATN1,PLAT,IL11RA,MBOAT7,PRPH,MYCN,SIGMAR1,C5AR1,UCP2,UBE2M,ANGPT1,EGR1,GFRA2,TRIB3,AXL,FOS,PLA2G4A,NR4A2,TF,NTRK3,LIMS1,ATP1A2,PEA15,PTGS2,PIN1,MAOA,SERPINI1,ADRBK1,CD4,MBP,KLF6,MAP1B,UNC5B,CXCL12,DNAJB2,HSPA5,CTSD,ETS2,PRND,GCLM,GSK3B,CAST,RET,BCKDK,FZD2,RTN4R,CXCL8,NOX4,STXBP1,MIF,ATF3,ITPR2,PAWR,PTGDS,SNRK,RASD1,GSR,BCL2L1,DUSP1,PRKCD,ALDH1A2,IGFBP3,NAGLU,AGAP3,CLCN7,SLC25A10,MDK,ESR1,MAP2K5,RUNX1,LEP,KCNK3,BMP2,VAPA,ABL1,CADPS2,HIF1A,NGF,GLRX,ETV6,PTPRF,HDGF,CIAPIN1,HMOX1,NFKBIA,THBS1,KCNMA1,C7,NSMF,ERBB2,FAM162A,ATP13A2,CHEK2,PRNP,AGT,FAAH,SRC,NLRP3,ATP2C1,FAM134B,NQO1,G6PD,PERP,LRRK2,PSME3,FAIM,SH3PXD2A,SERPINE2,RCAN1,CAPNS1,CAT,NDNF,CDC34,ELK1,KDR,DNM1L,P2RX7,MMP9	189	
Cardiovascular System Development and Function, Cell Morphology, Cellular Development, Organismal Development, Tissue Development	tubulation	tubulation of endothelial cells	7.28E-08	 	-0.393	 	-1.894	LEP,GBP1,FGF2,ADIPOQ,CXCL12,IL6,NEU1,EFNB2,ESAM,ID1,ANGPTL4,RHOB,EDN1,FLNA,KCNMA1,SAA1,MGP,CAV1,STIM1,SEMA3B,MAPKAPK2,NCKIPSD,TEK,FERMT3,SRC,CXCL8,ANGPT1,G6PD,THY1,VEGFC,PLAUR,MMP2,SLIT2,AXL,ID3,RCAN1,F11R,COL1A1,IGFBP3,ALCAM,CYR61,KDR	42	
Cell Morphology, Tissue Development	tubulation	tubulation of cells	7.30E-08	 	-1.364	bias	-3.173	BMP4,CXCL12,IL6,NEU1,ESAM,RHOB,MGP,CAV1,RET,TEK,FERMT3,CXCL8,VEGFC,THY1,MMP2,S1PR3,BSG,CDH5,IGFBP3,ALCAM,CYR61,mir-21,LEP,GBP1,FGF2,ADIPOQ,ID1,EFNB2,ANGPTL4,EDN1,KCNMA1,FLNA,SAA1,STIM1,SEMA3B,MAPKAPK2,NCKIPSD,SRC,ANGPT1,CXCR4,G6PD,PLAUR,SLIT2,AXL,ID3,COL1A1,F11R,RCAN1,S1PR1,KDR	50	
Cardiovascular System Development and Function, Organismal Development, Tissue Morphology	vasodilation	vasodilation of artery	7.86E-08	 	-0.541	 	-0.931	ADM,APOE,ZFP36,EFNB2,HMOX1,SHC1,ALDH2,MFAP2,RGS5,THBS1,ABCC1,MKL2,TMBIM1,ABCC9,ADRB2,AGT,ELN,SRC,GUCY1A3,MFAP5,PLAUR,HBEGF,THRA,S1PR3,LDLR,CBS/CBSL,LPAR1,CAT,EFEMP2,MMP9,CYP2C8	31	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	muscle tumor	muscle tumor	8.03E-08	 	 	 	 	SLIT3,RPE,MAP6,ASS1,CACNA1H,SLC39A8,CYBA,SMARCB1,MTHFD2,PLEKHO2,HES6,ALDH3A1,TACO1,CASQ2,SLC2A5,RBM38,ALDH1B1,RRP1,DPT,STK36,PLD3,NDUFS7,TNFRSF10B,CARMIL1,PTPN3,IFNAR2,WDR81,GALK1,CYP4B1,PPP1R15A,NCF2,BYSL,TRAPPC5,mir-21,FTH1,ERI3,NOL7,APOE,SLC4A2,FGF2,PHLDA2,GDF15,CDK4,TECR,RNF181,CHDH,SORBS1,RENBP,ALDH5A1,FCGR3A/FCGR3B,FCER2,HELZ,TJP1,NINL,IGF2R,GALM,FOS,MYOC,NR4A2,LDLR,GPBAR1,ATP6V0A2,LYN,XAF1,SLC22A18,TP53BP1,ADRA1A,MAOA,SOCS3,MEGF9,AKR1C3,PTTG1,PARP2,CLPP,MYC,CTSD,CXCL14,ZNF598,ERAL1,TUBA1C,CPNE1,KMT5A,H19,FMO2,LAMA2,ARSA,TXNRD1,BCL2L1,KCNG1,ABCA8,ADRA2A,DUSP1,HIF1AN,NDUFS3,CCPG1,ESR1,TXNRD2,DOCK6,SUN1,POLR3F,LOX,SFTPD,LITAF,FRZB,SCARA5,ATF6,SLC2A3,RPL14,SHC1,HLA-DRB1,RGS5,LRPPRC,ERBB2,GJA4,THBS4,NLRP3,TUBG1,PLAUR,PYGB,GATSL3,SNX27,CLEC16A,NUP210L,SLK,CXCL16,ACADVL,PIGB,TACC2,VAV3,FECH,GSTO2,DNM1L,MAP4K4,PRUNE2,DPYD,APOB,AHCYL1,MAF,HRAS,MST1,PPP4C,NR4A3,SP110,LPIN1,LGMN,MTUS1,PNKD,MED16,PKIA,WNT5B,CAPN5,SFRP4,ARHGEF4,CALCRL,CAPN6,NDRG1,SLC24A3,PCSK5,RRBP1,GSTM3,TUBB2A,KAZALD1,MMP2,HMGA1,AP2S1,UBQLN4,DOCK1,ACAD11,PTPRB,MAP3K20,ADAMTS18,RTN4,ALDOA,ME2,RSU1,HSPB7,SFRP1,CYR61,PDGFD,AKR1C4,TSPAN6,MYEOV,NOTCH1,DHRS4,MME,SORL1,SUSD2,ALDH4A1,GRB14,UQCRH,LEPR,HYOU1,TRPT1,PFKL,VCAN,EIF4EBP1,UCHL1,TRIB1,JUN,ALDH1A3,COL22A1,CD24,TBCD,KIAA0391,COL18A1,ECM2,PTPRT,ACVR1C,RNF135,FUK,SF3A2,PI4KA,DNAH6,MYCN,FMO3,BLMH,TYROBP,MGMT,HDC,DDX24,MVB12A,RELN,STXBP6,CYP1B1,MIOS,VPS9D1,COL5A3,KRT8,SBF1,LSP1,NR5A2,CBX4,PTGS2,FBN2,FAT1,LHCGR,LIPE,PIGQ,CCT8,CEL,TNIP1,CNDP2,ALDH1A1,ITGA11,SDPR,D2HGDH,RET,TRIM5,ADRA1B,PDK4,MT1G,HNMT,SPP1,ACP2,PCSK7,LMNA,ATP10A,C19orf48,TPSAB1/TPSB2,UBXN11,RPL9,SLC2A10,ITGAM,COL6A3,SRPK3,PKD1,RAP1GAP,RRP7A,CLCN7,CRABP2,AK2,--,ABL1,CDH23,SLC7A1,SMPD1,NGF,RAMP2,ANGPTL4,GNG11,CSPG4,MARCH8,CFB,RPS6KB2,KIT,MICALL1,STK24,ALPL,PTGER4,ADRB2,PRNP,FRMD1,DLGAP4,PARP10,METTL1,HYAL1,SMAD7,LRRK2,ZBTB7C,CSF1R,THRSP,FIZ1,COLEC11,ITPA,LRP1B,GBE1,NUCB2,KDR,P2RX7,MMP9	310	
Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis	8.22E-08	Increased	2.286	bias	-0.224	CH25H,PFN1,CD36,CD4,TYRO3,ELANE,RGCC,SH3GLB1,C1QA,IL6,BIN1,SPI1,CLIP1,MYC,PADI4,ETS2,ABR,CYBA,MCOLN3,PLA2G5,AMPH,LUM,CAV1,CLCN3,KLF2,GULP1,MARCO,CSF3R,PTX3,EIF2AK1,MIF,ATG7,CD302,CHN1,CAPG,HSPA8,DOCK1,COLEC12,ASGR1,ITGAM,PIP5K1C,RAP1GAP,PRKCD,CD14,FZD5,UVRAG,SLC11A1,CNN2,FYN,SFTPD,RALA,LEP,ABL1,ADIPOQ,ABCF1,SMPD1,GLRX,TGM2,HMOX1,RAB5A,THBS1,KCNMA1,ANXA5,SAA1,MEX3B,TUB,PRKCE,STIM1,MAPKAPK2,ADORA1,FCGR3A/FCGR3B,PTGER4,FCER2,SRC,UCP2,CSK,PLAUR,AXL,BTK,MYO5A,PLA2G4A,LAMP2,RRAS2,SWAP70,S100A9,WAS,CAT,ANXA3,PELI1,LYN,FCER1G,P2RX7	92	
Cell Death and Survival	cell death	cell death of fibroblast cell lines	8.59E-08	 	-0.215	 	-1.160	EIF3C,ITSN1,AXIN1,HRAS,EIF6,SLC9A1,COMMD4,SGPL1,EGR2,EIF3B,ABCC1,TSC2,SMARCB1,DNAJA3,ATF4,TXN,MCL1,ETS1,ATG7,COMP,DDIT4,FANCG,TNFRSF10B,IER3,NLRX1,IFNAR2,RTN4,CTSB,CYR61,FTH1,EPHX1,FYN,GADD45B,GSTM5,DDIT3,CDK4,TNFSF10,FNTA,EIF4EBP1,DDX3X,DIABLO,TGM2,ID1,CA3,MTOR,JUN,RASSF5,TRIM29,ATN1,MAPKAP1,MECOM,EGR1,CUL7,PLA2G4A,LAMP2,KRT8,NR4A2,BMF,FKBP4,BNIP3L,MAP3K8,PIN1,LIG1,VPS28,ADRBK1,CA4,DPYSL4,PARP2,UNC5B,SPHK2,KLF6,SDC4,HSPA5,MYC,CTSD,IKBKG,TNIP1,RHOB,NUPR1,GSK3B,BIRC3,EIF2AK1,SPP1,ATF3,SHARPIN,GNG2,PAWR,STX1A,BCL2L1,PKD1,PLEKHF1,PRKCD,ESR1,MLKL,S100P,SUN1,RUNX1,CDC20,ABL1,TNFAIP3,ATF6,SMPD1,HIF1A,NGF,HMOX1,HINT1,NFKBIA,STUB1,ERBB2,CUL9,PI4KB,AGT,PRNP,SRC,TRIP6,CSF1R,ENO1,FAF1,CAPNS1,RRAS2,UBA1,ELK1,DNM1L,YME1L1	124	
Cell Death and Survival	cell death	cell death of myeloid cells	8.63E-08	 	0.855	 	0.676	HAVCR2,RAN,ELANE,CXCL12,FCER1A,SERPINA3,C1QA,ABCG1,IL6,MYC,LTBR,CAST,GSK3B,BIRC3,MCL1,CXCL8,MIF,ATF3,BTG1,HAX1,TPSAB1/TPSB2,BCL2L1,ITGAM,PRKCD,CTSB,CD14,MAP2K3,NOTCH1,APOE,ADAM17,SFTPD,LEP,DDIT3,LEPR,NQO2,TNFSF10,CASP4,IRF3,HIF1A,NGF,IRAK1,HMOX1,LYZ,MTOR,NFKBIA,CCL2,PRKCE,S100A8,PCBP2,HCAR2,PLAT,NLRP3,CXCR4,CD69,NQO1,ST3GAL3,BTK,FOS,PLA2G4A,LDLR,CAT,LYN,FCER1G,MS4A2,ACAT1,PIN1,CXCL2,P2RX7	68	
Cellular Function and Maintenance	internalization	internalization by tumor cell lines	9.37E-08	Increased	2.173	bias	-0.108	APOE,ATP6V1D,CD36,RGCC,CXCL12,TNFSF10,IL6,LRRC29,ATP6AP1,SPI1,SF3B3,VCAN,NKAP,ASB1,TGM2,HMOX1,ETS2,CAV1,NAA60,DAB2,ERBB2,KLF2,PRNP,PTX3,CD209,AP2M1,SHARPIN,HBEGF,RPS21,AXL,HAX1,ATP6V1E1,SRSF3,PLA2G4A,ASGR1,RRAS2,ATP6V1F,PELI1,EPB41L2,P2RX7,ATP6V1B2,NRP1	42	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal adenoma	intestinal adenoma	9.68E-08	 	 	 	 	SLIT3,PHLDA1,C1orf115,AXIN1,NTMT1,CA12,CES2,GTF2IRD1,ODC1,AJUBA,SLC7A5,UNG,PDK4,SMPDL3A,PTGIS,AXIN2,DPT,C9orf16,BCL2L1,SORD,MRPL17,SLC22A5,BACE2,BYSL,CCDC80,EPB41L3,SCARA5,DNASE1L3,LEPR,ADIPOQ,CDK4,RUVBL1,CDKN2B,POLR1C,TIMP1,CLMN,HSD11B2,ASAP3,PTPRT,CCDC68,PSAT1,SRC,ATP2C1,SLC12A2,DGAT2,VSIG4,TRIB3,SLIT2,POLD1,PLA2G2A,C2orf88,SLC48A1,ATP6V1F,LPAR1,PAG1,JCHAIN,ANXA3,EPHB3,NR5A2,ITM2C,SOX9,NLE1,RDH5,PTGS2	64	
Cellular Function and Maintenance	function	function of blood cells	9.70E-08	 	0.077	 	-0.760	TYRO3,ELANE,CDKN2C,MST1,IL6,IDUA,LGMN,ABCC1,CAV1,MCL1,ETS1,TNFRSF21,CMKLR1,SELE,ATG7,PLEC,ANO6,FLOT1,THBD,NLRX1,IFNAR2,NINJ1,S1PR3,CARD9,AQP9,ARHGEF6,IL10RA,CD86,MAP2K3,SAC3D1,ANG,CNN2,APOE,FYN,GADD45B,ZFP36,PSMB10,GDF15,ADIPOQ,TNFSF10,G6PC3,TGM2,ID1,MCOLN1,MTOR,CCL2,RASSF5,LBP,PLAT,FCER2,CCR1,PLXNA1,SIGMAR1,CD209,CD276,UCP2,MECOM,TYROBP,IMPDH2,EGR1,CD69,RGS16,TOB1,TRIB3,AXL,ID3,GRN,GPR183,FOS,ARHGEF5,F11R,PLA2G4A,LY96,WAS,LSP1,LYN,FCER1G,S1PR1,MS4A2,ARHGDIA,PTGS2,NEDD9,ST3GAL4,ABCB6,RGS1,TNFRSF4,CD36,CD4,HAVCR2,UNC5B,SPHK2,PLA2G15,CXCL12,FCER1A,GPC3,CBX5,CEBPG,GPNMB,MYC,PADI4,PLA2G5,CLCN3,NSMAF,BIRC3,KLF2,RASGRP2,MARCO,STX11,EIF2AK1,CXCL8,MIF,SPP1,ATF3,ICA1,DOK2,PSME2,CAPG,PAWR,PKN1,APBA3,EFS,BCL2L1,ITGAM,DUSP1,PRKCD,CD14,IDO1,SFTPD,LEP,ABL1,TNFAIP3,SMPD1,IRAK1,HLA-G,CD55,NFKBIA,AHNAK,CSPG4,FLNA,KIT,HCST,PTGER4,ADRB2,RHBDD3,CD59,NLRP3,CXCR4,P2RX4,VSIG4,PLAUR,NFKBIZ,CSF1R,IL20RB,TNFRSF14,IL18RAP,BTK,RCAN1,RRAS2,JCHAIN,FASTK,KDR,RCAN2,P2RX7,MMP9	164	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	invasion	invasion of tumor	1.01E-07	 	1.315	 	-0.355	CTGF,PTTG1,LHCGR,CXCL12,HRAS,TYMP,IL6,HSPA5,TGFBR2,MIA,SATB2,RHOB,CAV1,GPC1,AHCY,ETS1,BIRC7,CDKN1C,SPP1,VEGFC,HBEGF,MMP2,KLF4,BSG,SCRIB,CTSB,ALCAM,CD14,RGN,CAPN2,ITGA1,SFRP1,MDK,NOTCH1,mir-21,VHL,MAP2K5,S100P,NRP1,COL7A1,APOE,NME1,LEP,FGF2,BMP2,WASF3,GDF15,ABL1,ADIPOQ,FKBP1A,HIF1A,VCAN,PDCD4,ID1,HMOX1,EDN1,CCL2,THBS1,FLNA,MCAM,CD24,ENPP2,S100A8,ERBB2,SOX7,SRC,CXCR4,HYAL1,PLAUR,SLIT2,S100A9,VAV3,PTGS2,NEDD9,MMP9	75	
Dermatological Diseases and Conditions, Organismal Injury and Abnormalities	skin abnormality	skin abnormality	1.03E-07	 	0.507	 	1.235	ABCB6,CSTA,HRAS,IL6,TGFBR2,ITGA3,IKBKG,TSC2,VEGFD,PTGIS,ELN,CXCL8,SELE,PARN,DKC1,PLEC,LMNA,VEGFC,ERCC2,PLOD1,S1PR3,IFT122,PKD1,RTN4,NOTCH1,DOCK6,VHL,EOGT,COL3A1,PYCR1,COL7A1,ADM,MME,APOE,B3GALT6,DDIT3,ANTXR1,CDK4,NHP2,FKBP1A,EIF4EBP1,EVC,COL1A2,COL5A1,HMOX1,B4GALT7,MTOR,NFKBIA,FLNA,KIT,KCTD1,GJB2,BEX2,PKP1,ABHD5,COL5A2,NLRP3,MECOM,SMAD7,NFKBIZ,SERPINE2,BTK,COL1A1,ZFPM2,LDLR,CYP4F22,ATP6V0A2,COL11A1,EFEMP2	69	
Cell Death and Survival	cell death	cell death of cervical cancer cell lines	1.03E-07	 	-0.649	 	-0.366	APOB,SGK1,TRAP1,CDKN2C,HRAS,MIF4GD,IL6,ATP2A2,CCND3,CYBA,MCOLN3,TSC2,DNAJA3,TXN,MCL1,TNFRSF21,BIRC7,ATG7,CENPB,TNFRSF10B,RPA1,TNK2,IER3,MAP3K12,TNPO2,PDLIM7,CCND2,ARHGEF6,CTSB,SQSTM1,FTH1,NME1,RAB32,EMILIN2,GADD45B,ZFP36,DDIT3,SIN3B,GNA11,TNFSF10,CASP4,NAA35,GRINA,DIABLO,UCHL1,MCOLN1,MTOR,LCMT1,JUN,ACSM5,GADD45A,DAP3,PCBP2,ATN1,RPS24,MAPKAP1,ADRM1,UCP2,ARHGAP4,NABP1,FOS,NR4A2,IMMT,HNRNPH1,LIMS1,BNIP3L,NEDD9,PRPF19,ATP2B1,HSPA1A/HSPA1B,OGFOD1,STYXL1,MYC,G0S2,PUF60,GSK3B,FST,SPP1,LMNA,PAWR,TXNRD1,BCL2L1,ITPK1,PPP2R1A,NOL3,PRKCD,PIDD1,ESR1,TNFAIP8,CDC20,PTPMT1,PKM,ABL1,HNRNPK,MAN2C1,NFKBIA,NEK7,RNF144B,MCRS1,PAK4,PARVA,TAF6,NFKBIZ,CSF1R,CAT,DNM1L	106	
Cell-To-Cell Signaling and Interaction	attachment	attachment of cells	1.07E-07	 	-0.413	bias	-2.174	FYN,LOX,CTGF,BMP4,FGF2,CD36,BMP2,ANTXR1,PKM,ADIPOQ,CXCL12,HRAS,IL6,SPI1,VCAN,TGM2,IPO9,ITGA3,RHOB,DAB2,C1QBP,TEK,ETS1,ELN,SRC,CD209,VCAM1,SELE,COMP,SPP1,ANGPT1,EGR1,THY1,MMP2,TFPI2,F11R,PMP22,TLN2,SWAP70,PRKCD,SPRY2,SPARC,ITGA1,MAPK7,NEDD9,DSG2,VHL	47	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	morphology	morphology of heart ventricle	1.11E-07	 	 	 	 	APOB,ADRBK1,IL6,BIN1,ATP2A2,POR,IDUA,PLCE1,CCND3,GAA,RARA,CAV1,HEY2,CASQ2,ADRA1B,TEK,ELN,HEYL,SGCG,LMNA,HBEGF,MMP2,DCHS1,BCL2L1,DOCK1,TIMP4,NOL3,CCND2,MAPK7,MEGF8,TXNRD2,ADM,SPTBN1,APOE,ADAM17,ABL1,ADIPOQ,FKBP1A,HIF1A,MYH11,RAMP2,SHC1,HMOX1,EDN1,THBS1,LY6E,GNG5,COL18A1,PTGER4,HEY1,VCAM1,DHRS3,CXCR4,SMAD7,SLCO2A1,IGF2R,PLA2G4A,ZFPM2,LDLR,NTRK3,SGCD,MMP9	62	
Cardiovascular Disease	aneurysm	aneurysm	1.13E-07	 	-0.832	 	-0.388	ADM,RUNX1,LOX,APOE,MYLK,MYH11,TGFBR2,EFNB2,TIMP1,CST3,MGP,MKL2,KLF2,PTGER4,AGT,ELN,CTSK,COL5A2,SPP1,MFAP5,ATP2C1,RRBP1,SGCB,MMP2,RCAN1,COL1A1,LDLR,ADRA2A,CBS/CBSL,EDNRA,SPARC,PTGS2,KDR,EFEMP2,MMP9,VHL,COL3A1	37	
Infectious Diseases	infection	Viral Infection	1.14E-07	Increased	7.109	bias	2.038	IL6,POR,CSE1L,MARCH2,SMARCB1,MAP1A,DMAP1,FBL,CLEC4G,NDUFS7,CTSB,ATOX1,mir-21,GBP1,DDIT3,EIF4EBP2,DAPK2,ADIPOQ,FNTA,DDX3X,C1R,LY6E,MECOM,CD69,POLR1E,SPATS2L,PVR,PSMB6,IGF2R,HNRNPH1,GCSH,SOCS3,HAVCR2,RABEP1,AP1B1,EXOSC3,NDUFA10,TUBA1C,VNN2,BIRC3,CXCL8,STXBP1,STK39,MAPK8IP2,RIMS4,POLR2H,FCN3,BCL2L1,AES,AEBP2,H3F3A/H3F3B,ADRA2A,SFTPD,KCNK3,BMP2,F8,EPN1,PACS1,RNF26,PLAUR,SPARC,MAP4K4,EIF3C,MSRB2,TYRO3,RAN,SLC15A4,RAD23A,SGPL1,ITGA3,SP110,PRG4,RARA,MED16,POLR2I,RND2,CAPN6,CMKLR1,ATG7,MT1X,TIMM17B,GRK5,HMGA1,MNDA,THBD,NLRX1,LARGE1,MAP3K12,FAM86B1,COL3A1,NRP1,FYN,FCGRT,ATP6V0B,HEATR1,FKBP1A,TBL3,TRPT1,COASY,ATP6AP1,EIF4EBP1,JUN,CCL8,PDE3B,CSF2RA,CST3,CD24,HGS,CD209,ANKRD9,EGR1,MED30,TMED2,LRSAM1,SLIT2,AXL,GABRE,DCAF13,RNF144A,RBM42,BRINP2,PTGS2,TNFRSF4,CD4,CD36,CLIP3,DNAJB2,IKBKG,ETS2,AMPH,MID1IP1,SNU13,GSK3B,WDR46,STX11,FERMT3,PACSIN3,CYYR1,TALDO1,HSPA9,SLC4A7,NDUFAF2,CYSTM1,AGTRAP,TPSAB1/TPSB2,GPR146,KIAA0922,ATPIF1,KBTBD11,PRKCD,CD14,RARRES3,IDO1,XPNPEP1,UVRAG,UTP11,SH3BP4,ATF5,NGF,RRAGD,SSU72,CD55,RAB5A,NFKBIA,NCL,SULF2,AP2M1,EPAS1,ATP2C1,PCOLCE2,MRPS12,APOC1,PDE8B,UQCRC1,XK,CLEC10A,HLA-DOA,SPI1,MTX1,GATAD2A,CAV1,ATF4,KAT2A,VPS4B,TNFRSF10B,LAMC3,IFNAR2,TRAPPC1,NRBP1,TMEM127,FSCN1,BTG2,PPP1R15A,APOBEC3C,ATMIN,TFRC,CD86,GAPDH,ERI3,RNF10,APOE,CDK4,CEBPD,UBE2Z,TECR,USP39,IFI27,CCL2,CSNK2B,PIK3R2,TRIM29,ADORA1,RAD21,FCGR3A/FCGR3B,CYP51A1,G3BP2,S100A1,CCR1,SIGMAR1,MED20,DGAT2,SLCO2A1,ST3GAL3,HP,LDLR,ATP1A2,POLA2,MAN2B1,MSRA,AFG3L2,PIN1,ADRA1A,MT2A,CH25H,AMDHD2,PTTG1,HSPA5,MYC,TGFBR2,PADI4,HSPA4,RHOB,MAP2K2,STAB1,NEDD4L,CHMP1A,GM2A,LAMA2,PSME2,DDOST,OSBPL7,ANO1,CDC42BPB,SDCBP,DUSP1,EDEM1,ESR1,C2,S100P,RUNX1,ZNRD1,POLR3F,NMT1,PTPMT1,CCL3,SLC2A3,VPS4A,HNRNPK,TIMP1,MCAM,RNH1,LOC102724428/SIK1,LONP1,PARVA,APBB1IP,TUBG1,TNFRSF14,CAT,UBE2E2,DNM1L,GAPVD1,ALKBH3,ISG20,APOB,CAMK1,AHCYL1,SGK1,ELANE,HRAS,GAA,DNAJA3,IRS2,TXN,PCSK5,FANCG,TUBB2A,TNK2,IER3,UBQLN4,RAE1,BSG,PIP5K1C,MS4A4A,STIP1,IL10RA,GLUL,MAP2K3,IFIT2,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,RAB32,SRD5A1,TNFSF10,PFKL,DCLK1,IDH1,COL5A1,DCLK2,EFNB2,MTOR,CCL3L1,CCL3L3,ANXA5,SNX10,SOCS2,PSMD14,PCBP2,PLOD3,PI4KA,PLAT,VPS18,IMPDH2,TYROBP,DEFB1,MVB12A,POLD1,F11R,LAMP2,KRT8,S100A9,SPRY2,LSP1,PELI1,C6orf48,GABARAP,VPS28,ADRBK1,CLTB,CXCL12,TUBB,LOC102724828/MRPL23,CEL,PARVB,LARS,ASXL2,GABARAPL1,IMPA2,KLF2,TRIM5,AGBL5,ADRA1B,GPR1,PTX3,CSF3R,MIF,SPP1,APLNR,NUP155,PCSK7,LMNA,MYOF,PANK1,ITGAM,ERCC1,SRPK3,PKD1,PCGF1,KATNB1,MAP2K5,LEP,ERN1,ABL1,IRF3,NAA10,EPHB6,HMOX1,CCL13,FLNA,CLOCK,MICALL1,PSMA3,S100A8,HMGCS1,ACTN1,NDUFAF3,PRNP,DLGAP4,CXCR4,AP3D1,EXOSC5,F13A1,NFKBIZ,TRMT61A,JCHAIN,EDNRA,RTN3,DSG2,MMP9,ATP6V1B2,P2RX7	411	
Inflammatory Response	immune response	immune response of cells	1.20E-07	Increased	2.507	 	-0.050	SGK1,TYRO3,ELANE,CTSG,C1QA,IL6,SPI1,CLIP1,ABR,CYBA,LUM,CAV1,MCL1,ETS1,ATG7,CHN1,SLX4,THY1,HBEGF,THBD,NLRX1,ROR1,IFNAR2,HSPA8,CARD9,DOCK1,COLEC12,ASGR1,HLA-DRB4,CD68,PIP5K1C,IL10RA,CTSB,GAPDH,CD86,CNN2,APOE,FYN,RALA,HSDL1,EIF4EBP2,SLC1A5,LEPR,ADIPOQ,TNFSF10,MMP25,G6PC3,EIF4EBP1,TGM2,MTOR,IRF2BP1,CCL2,CST3,ANXA5,TUB,PRKCE,STIM1,ADORA1,FCGR3A/FCGR3B,PLXNA1,C5AR1,UCP2,SPRY1,TYROBP,CSK,CD69,AXL,OTUB2,CYP1B1,OTUB1,PLA2G4A,LY96,SWAP70,NR4A2,S100A9,WAS,SPRY2,ANXA3,PELI1,LYN,FCER1G,MAP3K8,CH25H,SOCS3,TNFRSF4,PFN1,CD36,CD4,HAVCR2,RGCC,FCER1A,BIN1,TRIM47,MYC,TGFBR2,PADI4,CTSD,IKBKG,ETS2,PLA2G5,RET,CLCN3,BIRC3,KLF2,TRIM5,GULP1,MARCO,CSF3R,EIF2AK1,PTX3,CXCL8,MIF,CD302,PSME2,CAPG,PGAP3,MLST8,BCL2L1,GZMH,ITGAM,RAP1GAP,PRKCD,CD14,FZD5,UVRAG,SLC11A1,LITAF,SFTPD,LEP,ERN1,ABL1,ABCF1,SMPD1,IRF3,CCL3,GLRX,GSTT1,IRAK1,HMOX1,CD55,TRIM6,THBS1,SAA1,MEX3B,S100A8,ERBB2,MAPKAPK2,PTGER4,PRNP,AGT,SRC,VCAM1,CD59,NLRP3,SMAD7,PLAUR,BTK,KIF2A,RRAS2,CAT,DNM1L,P2RX7	162	
Cellular Function and Maintenance	function	function of leukocytes	1.24E-07	 	-0.174	 	-0.935	TYRO3,ELANE,MST1,CDKN2C,IL6,IDUA,LGMN,ABCC1,CAV1,MCL1,ETS1,TNFRSF21,CMKLR1,SELE,PLEC,FLOT1,THBD,NLRX1,IFNAR2,NINJ1,S1PR3,CARD9,ARHGEF6,IL10RA,CD86,MAP2K3,SAC3D1,ANG,CNN2,FYN,APOE,GADD45B,ZFP36,PSMB10,GDF15,ADIPOQ,TNFSF10,G6PC3,TGM2,MCOLN1,MTOR,CCL2,LBP,RASSF5,PLAT,FCER2,CCR1,PLXNA1,CD209,SIGMAR1,CD276,UCP2,TYROBP,IMPDH2,EGR1,CD69,RGS16,TOB1,TRIB3,AXL,ID3,GRN,GPR183,FOS,ARHGEF5,F11R,PLA2G4A,LY96,WAS,LSP1,LYN,FCER1G,S1PR1,MS4A2,ARHGDIA,PTGS2,NEDD9,RGS1,TNFRSF4,CD36,CD4,HAVCR2,UNC5B,SPHK2,PLA2G15,CXCL12,FCER1A,CBX5,CEBPG,GPNMB,MYC,PADI4,PLA2G5,CLCN3,BIRC3,KLF2,NSMAF,RASGRP2,STX11,MARCO,CXCL8,MIF,SPP1,ATF3,ICA1,DOK2,PSME2,CAPG,PAWR,PKN1,APBA3,BCL2L1,EFS,ITGAM,DUSP1,PRKCD,CD14,IDO1,SFTPD,LEP,ABL1,TNFAIP3,SMPD1,IRAK1,HLA-G,NFKBIA,AHNAK,CSPG4,KIT,HCST,PTGER4,ADRB2,RHBDD3,NLRP3,CXCR4,P2RX4,PLAUR,NFKBIZ,IL20RB,CSF1R,TNFRSF14,IL18RAP,BTK,RCAN1,RRAS2,JCHAIN,FASTK,KDR,RCAN2,P2RX7,MMP9	151	
Cancer, Organismal Injury and Abnormalities	urogenital cancer	urogenital cancer	1.34E-07	 	-0.196	 	-0.128	PCLO,ASS1,VAC14,PAQR7,TLE1,SLC39A8,POR,GLB1,AJUBA,PPRC1,SMARCB1,TSC2,DEFB132,VIT,WASH3P,DDIT4,SLX4,KIAA1147,RANBP3,LARP4,HLA-DRB4,CDH5,ALCAM,C14orf79,BRE,KIAA1217,mir-21,FHL1,GBP1,ADIPOQ,MFSD5,TUBB2B,SYNM,DIABLO,C1R,RABL6,TIPARP,LY6E,EMP3,ID3,GPR183,PDZD2,AFF3,COG5,KIF7,SWAP70,CBS/CBSL,TBC1D8,GCSH,WBP2,AKR1C3,RGCC,TRPM8,TMEM169,DIRAS1,DNAJC15,INTS1,LHFPL2,ANKDD1A,TUBA1C,VNN2,BIRC3,TEK,ADAMTS1,GUF1,FAAP20,KANK1,BCL2L1,RPL8,CRHBP,PSME4,C17orf97,BAIAP2L2,SUN1,ETV5,FEM1A,RPH3AL,ZNF252P,CLUAP1,KCNS3,SH3PXD2B,F8,NLRP3,PLAUR,PYGB,SAA2,SNX27,FRMD4A,CLEC16A,RRAS2,SPARC,ANO3,FECH,TSC22D1,ING1,CXCL2,MED24,EIF3C,ASPSCR1,GFPT1,CTGF,MSRB2,GMDS,PPP4C,SGPL1,SP110,SLC22A15,PRG4,ZNF605,MCL1,PPIL6,PIK3C2B,BIRC7,DFNA5,ATG7,CENPB,PLEC,HBEGF,TMEM267,GRK5,PARP3,HMGA1,CREB5,THBD,FAHD2B,NINJ1,SH3GL1,CCDC136,MS4A14,FAM86B1,ACAD11,NCLN,TMEM158,NOTCH1,EOGT,NRP1,ILVBL,COL3A1,SORL1,CPSF2,ABI3BP,SERAC1,RP9,ZFP36,LEPR,NQO2,SIN3B,ST6GALNAC4,FKBP1A,CASP4,MEOX2,ATP6AP1,KLF9,CADM2,ENTPD6,DIP2B,COL22A1,TXNL1,HGS,AHNAK2,GJB2,NPRL2,LIMCH1,RPS24,NAP1L4,CD209,SLC25A13,CD276,BLMH,COL12A1,MED30,DDX24,RELN,NTM,DHCR24,SBF1,TMEM63B,PTGS2,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,SPNS1,CLIP3,CLEC3B,TBX15,LHCGR,SLC35F1,DNAJB2,ZNF91,FAM173A,CNDP2,PLCE1,ETS2,DHTKD1,ACP6,COMT,MCTP1,NMNAT2,NAV1,PGP,EGR3,USP36,FBXO22,PAWR,ATP10A,ALAD,NDUFAF2,ZMYND15,TPSAB1/TPSB2,INHBB,GPR146,SORD,LRRC41,COL6A3,SCRIB,LMAN2L,UVRAG,CDK5RAP2,ICK,NGF,PTPRF,SSU72,THBS1,ASAP3,ZNF493,TMEM104,TPST2,ATP2C1,C9orf3,LRRK2,TANC2,ANO2,NCAPH2,COL1A1,PLEKHH1,PAG1,PLP2,XK,SLC47A1,SLIT3,NIPA2,SVEP1,SYTL2,MAP6,CACNA1H,SLC35C1,RNF125,ODC1,SUSD1,RNASE4,NPL,OGFOD3,NUP93,CYBA,GPRC5C,EFHB,ARHGAP39,ALDH3A1,SPATA18,TSHZ2,NSUN4,ALDH1B1,DPT,SOGA1,MFAP5,TNFRSF10B,CARMIL1,RUNDC3B,OSBPL10,RPAP3,PLLP,TNPO2,MN1,ZNF606,SLC16A5,PPP1R15A,ARHGEF6,GCC1,TFRC,ZDHHC1,IGSF10,PTPRA,APOE,NME1,PLXNA3,FBXO10,NACC2,IGSF1,CUBN,GDF15,CDK4,CTDSPL,TECR,ZNF285,IFI27,RNF181,DUSP5,POFUT2,CCL2,ARFGAP1,PLIN2,SOS1,DAB2,ADORA1,HCAR2,RAD21,CYP51A1,LIG3,CCR1,S100A1,SIGMAR1,HELZ,MED20,TJP1,DGAT2,STON1,ARHGEF5,LDLR,ZFPM2,ATP6V0A2,TP53BP1,BMPER,BMP6,ST3GAL4,CPXM1,ADRA1A,HAGH,KTN1,BZW2,NOC3L,USP5,ABCA3,HSPA1A/HSPA1B,PPFIBP2,TIGD2,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GPX3,TPRN,RHOB,MOCOS,CXCL14,ZNF598,GIMAP5,GYPE,STAB1,LILRB5,KIF25,FMO4,RPAP1,GULP1,POLR3C,ATF3,PKP2,RILPL1,STARD5,VEGFC,DCHS1,FOSB,SDCBP,TLN2,ABCA8,MATN2,GIPC1,APCDD1,ALDH1A2,SORCS2,THAP7,CCPG1,ESR1,LRRC47,S100P,MAST2,PTGFR,ERAP2,FAM107A,SLC1A4,CDC20,SRPX,FRZB,DENND4B,ZSWIM3,DCAF4,SLC15A3,GSTT1,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,AHNAK,RGS5,TIMP1,OLFML2A,DNAJC4,MCAM,LOC102724428/SIK1,VARS,GJA4,SLC20A1,VCAM1,PARVA,NUSAP1,APBB1IP,AP1S2,SLC12A2,XRN2,UPP1,PGAP2,GNAI1,ZNF16,N4BP1,PSME3,ATIC,SH3PXD2A,CLGN,VAV3,LPAR5,MIB2,SGK1,MAF,ELANE,CDKN2C,GTF2IRD1,HOXA9,NCOA7,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,CSTF2,ALPK1,GUCY1A3,MMP2,IER3,SCNN1D,RAD51D,RAE1,DOCK1,AQP9,SRGAP3,MS4A4A,C11orf80,MAP3K20,MS4A7,IL10RA,TRO,RPL6,LRP8,AIDA,SLC35A4,PHLPP1,HIST2H2AA3/HIST2H2AA4,ALDH4A1,RALA,CHCHD6,KAZN,KHDC1,VCAN,TRIB1,MTOR,SRGAP1,ANXA5,SOCS2,ACSL4,PRKCE,TBCD,LPP,COL18A1,PLAT,PTK7,DNAH6,CYP11A1,C9orf142,GSTM1,MFAP4,STXBP6,PCDH9,MRPL51,COL5A3,CLDN5,MCM2,CHFR,PEA15,DBNL,ZFP36L2,SCAMP3,FZD7,NAGK,ADRBK1,XXYLT1,FNIP2,ARG2,COBL,KPNA2,SIAH2,MYO10,FAM65B,AGBL5,CSF3R,NUP155,C8orf46,SPP1,ITPR2,ZNF408,PCSK7,LMNA,MYOF,EIF2S2,DPP9,GSR,PANK1,RRP7A,HSPA13,RGN,AKR1B1,THSD7B,MAP2K5,COL7A1,RNPEP,DRAP1,AOC3,ADAMTS7,LEP,FLRT2,ANTXR1,PNMAL1,RAMP2,ADSL,ZMAT3,FLNA,FUBP3,HIST2H2AC,PSMA3,S100A8,RNF144B,MYO16,PRRT3,TMEM132B,RAB11FIP3,SNAPC4,SPOCD1,FRMD1,LCLAT1,AP3D1,CPED1,SMAD7,F13A1,MKNK2,CSF1R,ENO1,ITPA,LRP1B,DYM,OLFML2B,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,ATP6V1B2,MMP9,SHMT2,CBX7,SLC6A9,AXIN1,PPP2R3B,TPRG1,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,UPK3BL,CCND3,ATG9A,CSE1L,MAP1A,SLC2A5,PTGIS,FBL,GFM1,PTPN3,PDLIM7,CTSB,EPHX1,CD163L1,COL4A5,PSMD7,MRPL38,COL15A1,DDX3X,DTNA,ABCC9,GTF3C1,MECOM,CD69,KIAA1549L,SPATS2L,CDO1,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,LIG1,SOCS3,ARSD,RABEP1,MICALL2,AP1B1,GPC3,CEP104,ZNF75D,ARHGAP20,CCT5,ACTG2,MARCO,KMT5A,CXCL8,STXBP1,TJP2,H19,ARL17A/ARL17B,MAN1C1,STK39,MAPK8IP2,BAMBI,H6PD,FIG4,RAB34,ERCC2,TXNRD1,AEBP2,GPS1,SLC7A2,BAP1,CCDC80,TNS1,GSDMC,SYN1,SLC11A1,VHL,SULF1,IGFBP4,LITAF,PC,PLGRKT,HABP4,PHLDB2,COL6A6,HLA-G,DHCR7,ESPNL,EDN1,GTPBP2,FARS2,ERBB2,THBS4,SRC,PKP1,G6PD,NSFL1C,AP3B2,APOLD1,POLR3B,ITM2C,COL11A1,CERCAM,PRUNE2,KCND2,DDX11,BMP4,CMTM4,TYRO3,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,EVI5L,ITGA3,LGMN,IRX3,KIF21A,MGAT4B,AFAP1,FAM127A,CAPN5,EFL1,SFRP4,CMKLR1,CAPN6,ZC3HC1,ATP8B4,CEP89,JUNB,MNDA,BCAP29,DPH2,CLEC4F,CCZ1/CCZ1B,AAAS,EPB42,RTN4,CCT3,ALAS2,ANG,FYN,GSTM5,BTG3,HEATR1,TTLL4,SLC1A3,GOLGA3,TBL3,RCOR2,ABCA5,CORO2B,THBS3,EIF4EBP1,MCOLN1,STOM,LYZ,CES1,KAT2B,JUN,ZNF334,PDE3B,CLEC14A,CD24,MYO1D,NPTXR,ZFAND2B,ECM2,FUK,PLXNA1,CEP164,MYOM2,LRSAM1,SLIT2,NBEA,TMEM42,AXL,EMC1,GABRE,PLA2G2A,TRMT12,DCAF13,LMO3,IMMT,RNF144A,GALE,ANXA3,CILP,ATAD3A,TM4SF1,LRFN4,TFF3,FARP1,FAT1,MAP1B,PIGQ,GUSB,METAP2,WDR5,GSPT1,ALDH1A1,MYOM1,TTLL12,PLA2G5,AMPH,GSK3B,GPC1,RET,MFSD3,STX11,KLHDC3,HK1,FERMT3,MT1G,TTYH1,ACSL3,PTPRE,TRIOBP,GSDMB,RPUSD1,TALDO1,MAPK8IP3,GPAA1,FLCN,KIAA0922,RAP1GAP,PRKCD,N6AMT1,C2orf40,IDO1,XPNPEP1,CRABP2,SH3BP4,SH3RF3,SLC4A11,IPO9,CD55,NFKBIA,HSPE1,SMO,CFB,STK24,IFRD1,MAPKAPK2,KCTD1,GOT2,ACADM,CHEK2,ADRB2,ZFP42,EMILIN1,LXN,EPAS1,PHLDA3,DHX37,CIART,COLEC11,C2orf88,GLMP,ACAT1,EPHB3,GBE1,PDE8B,C6,KDR,DHRS7B,NDUFA9,WBSCR22,ASCC1,C1QC,SERPINA3,PLEKHM2,CLIP1,FADS3,ZNF263,EGR2,CTSH,KEAP1,LUM,MTHFD2,CEP170B,ST6GALNAC2,KANK3,MGP,CAV1,ATF4,STK32A,EBF2,HIPK2,CDC16,PIGT,RNF121,TM6SF1,SELE,STK36,PPP1R1B,ANO6,SMG5,MASP1,FLOT1,THOP1,IFNAR2,TFPI2,SHROOM4,TMEM127,EVPL,NRDE2,CTSA,LRRN3,VARS2,BTG2,ATMIN,GAPDH,ITGA1,CXorf57,SAMD4A,FGF2,OSGIN1,CCDC167,UBE2Z,ZBTB9,TOM1L2,HS3ST3A1,LAMP3,MRPL22,TGM2,CS,SORBS1,IL34,PIK3R2,TBC1D10B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,MAPKAP1,NINL,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,LRRC75B,TMEM106C,TAF1C,XAF1,SLC22A18,MAP3K8,AARS2,SEMA3C,ABCC3,RBP5,C11orf68,QPCT,TRAPPC2L,ATP13A1,SESN2,ATP2B1,PTTG1,MBP,PARP2,KLF6,POLR3E,STARD7,HSPA5,PADI4,GPR4,KCNAB1,TMEM8B,CAST,PDZRN3,LACTB,LRBA,MAST4,DOK2,GM2A,LAMA2,SRPRB,UNC13B,PTGDS,KLF4,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,RUNX1,TPR,COPE,ABCF1,ATF6,GTF3A,NAT14,KIFC2,CCL3,HNRNPK,GCDH,RPL14,POLR1C,MSRB3,SLC19A3,SAA1,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,SLC22A12,TUBG1,NQO1,EMD,GATSL3,LARP6,CXCL16,ADGRG1,CIDEA,PMP22,CES4A,ASTN2,HEPACAM,SMG7,CDC34,ALKBH3,DNM1L,NNAT,SLC29A4,KCNK15,CAMK1,APOB,ITSN1,AHCYL1,WDR45,TGFBR3,FAM58A,HRAS,SNAP47,RAPH1,SATB2,ANK2,IRS2,EYA2,CACHD1,CALCRL,ITM2A,NANOS1,SLC24A3,PCSK5,RRBP1,TUBB2A,THY1,CPA3,TNK2,CRABP1,CTPS1,TAF9B,COLEC12,CDH2,TIMP4,CDH12,CCND2,CD68,BSG,PTPRB,NPRL3,CDRT1,ADAMTS18,ADM2,SPINT2,GLUL,RSU1,MAP2K3,MAPK7,ZER1,SFRP1,CYR61,MYEOV,ADM,MME,SPTBN1,HIST1H1C,MSC,ADAM17,SRD5A1,WASF3,TNFSF10,XPOT,ADAP2,TTC1,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,COL5A1,EFNB2,SEC61A1,SLC2A6,CMTM8,SNX10,CLMN,STIM1,SH3GLB2,TPO,PRPF31,PTPRT,AMFR,PI4KA,SLC7A6,MBOAT7,MYCN,VPS18,FMO3,ANGPT1,TWNK,MGMT,MVB12A,DEFB1,CYP1B1,RHPN2,SUPV3L1,KRT8,PLEKHG6,TF,S100A9,CDK20,PPP1R16B,CNN1,NOP2,ADCY1,MS4A2,NR5A2,ALS2CL,BNIP3L,DVL3,GABARAP,FBN2,EFR3A,RGS1,PHLDA1,SPHK2,XPO5,CXCL12,HARS,IL17RC,TPM1,TUBB,MTCH2,PARVB,TNIP1,ASXL2,NEO1,SLC7A5,PUF60,KLF2,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,ZNF616,FOXC1,PKN1,EPRS,STC1,PPP2R1A,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,TMOD1,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,RARRES1,SLC7A1,TET1,SMPD1,MYLK,HIF1A,ACOT7,CDKN2B,FAM110B,EVC,COL1A2,EPHB6,SOX17,NFX1,HMOX1,PCK2,CSPG4,KCNMA1,C7,KIT,NEK7,CUL9,ALPL,STK40,PI4KB,ACTN1,PTGER4,ASIP,FAAH,MIPEP,CXCR4,QSOX1,ZBTB7C,NFKBIZ,NEK11,CYTIP,LPAR1,TSPAN1,JCHAIN,EDNRA,RTN3,RCAN2	1214	
Neurological Disease, Psychological Disorders	dementia	Dementia	1.36E-07	 	 	 	 	CTGF,APOB,TGFBR3,RAN,NCSTN,SERPINA3,IL6,ADGRL1,EEF1G,LGMN,SPTLC2,CAV1,ATF4,LSS,TXN,UNG,TSHZ2,PLD3,OSBPL10,THY1,LARP4,MMP2,CHI3L2,HMGA1,CRABP1,CD68,MS4A4A,STIP1,CTSB,GAPDH,LRP8,SQSTM1,PLTP,NOTCH1,MME,SORL1,APOE,DDIT3,CHCHD10,FGF2,CDK4,SLC1A3,CASP4,MEOX2,MYH11,EIF4EBP1,C1R,UCHL1,SPON1,TGM2,DTNA,MTOR,JUN,GBA,CCL2,CST3,PDE3B,PRKCE,LDLRAP1,FCGR3A/FCGR3B,ALDH5A1,PLAT,CYP11A1,BLMH,TYROBP,APBB3,SLCO2A1,RELN,ACLY,GABRE,PLA2G2A,GRN,HP,LDLR,TF,CBS/CBSL,DHCR24,S100A9,NTRK3,LIMS1,CNN1,TAGLN,PTGS2,BMP6,ADRA1A,MAOA,QPCT,CH25H,CD36,HSPA1A/HSPA1B,CLEC3B,CXCL12,HSPA5,TUBB,BIN1,TGFBR2,CTSD,ETS2,AMPH,NAV1,GSK3B,RTN4R,ADRA1B,IGFBP6,CXCL8,NBAS,GM2A,MACROD1,HSPA9,PAWR,PTGDS,EPRS,OGN,ADRA2A,PRKCD,SLC7A2,IGFBP3,CD14,ESR1,DOK5,LEP,FEM1A,SMPD1,CADPS2,HIF1A,NGF,CCL3,GLRX,SLC2A3,HMOX1,ALDH2,DHCR7,STUB1,TIMP1,BCYRN1,C7,CFB,IGSF8,HMGCL,PTGER4,ADRB2,PRNP,AGT,FAAH,CXCR4,NQO1,CANX,CSF1R,SERPINE2,CXCL16,RCAN1,TMEM2,LRP1B,APOC1,SPARC,GAP43,GAPVD1,DNM1L,RTN3,MMP9	160	
Cell Death and Survival	cell death	cell death of carcinoma cell lines	1.39E-07	 	-1.291	 	-1.121	DPYD,PFKFB1,KLF6,ACO2,TRAP1,CXCL12,CDKN2C,SERPINA3,IL6,DNAJC15,HSPA5,GPC3,AP2A2,MYC,SATB2,RHOB,MTUS1,ETS2,KEAP1,ABCC1,GSK3B,RET,KLF2,MCL1,HK1,CERS6,IGFBP6,ATG7,SPP1,NDRG1,PPP1R1B,TNFRSF10B,THY1,PAWR,HMGA1,TNK2,TXNRD1,RASD1,BCL2L1,CCND2,TRIM39,DUSP1,PRKCD,BAP1,CTSB,IGFBP3,GAPDH,SFRP1,MDK,NOTCH1,mir-21,PMEPA1,SULF1,ADAM17,DDIT3,FGF2,OSGIN1,PKM,ADIPOQ,TNFSF10,ATF6,HIF1A,PDCD4,UCHL1,TGM2,HMOX1,MTOR,NFKBIA,JUN,PRKCE,STIM1,ERBB2,SEMA3B,HCST,PTPRT,CHEK2,SRC,EPAS1,NQO1,AXL,ID3,GRN,NR4A2,HNRNPH1,SPRY2,PEA15,ING1,PTGS2	88	
Cardiovascular System Development and Function, Hematological System Development and Function	blood pressure	blood pressure	1.39E-07	 	-0.956	 	-0.571	APOB,ADRBK1,SGK1,CD36,SNTA1,CXCL12,POMC,ARG2,IL6,SDC4,SLC9A1,ATP2A2,IDUA,CYBA,ABCC1,CAV1,IRS2,NEDD4L,ADRA1B,PTGIS,ELN,APLNR,SPP1,DBP,GUCY1A3,STK39,VEGFC,IER3,AGTRAP,STC1,NOL3,ADRA2A,NPR3,DUSP1,NCF2,SNX1,ADM2,mir-21,RBP4,TEF,RNPEP,ADM,AOC3,SPX,APOE,ERAP2,LEP,ZFP36,LEPR,FGF2,ADIPOQ,TNFSF10,SLC7A1,HIF1A,MYH11,RAMP2,COL1A2,EPHB6,HMOX1,ALDH2,EDN1,RGS5,TIMP1,THBS1,KCNMA1,RENBP,HSD11B2,ABCC9,ADORA1,ADRB2,ASIP,PLAT,AGT,EPAS1,UCP2,RNLS,P2RX4,SLC12A2,LRRK2,PLAUR,F11R,PLA2G4A,SLC2A8,LDLR,VAV3,ATP1A2,EDNRA,PTGS2,MMP9,ADRA1A,MAOA,CYP2C8	92	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	polyarticular juvenile rheumatoid arthritis	polyarticular juvenile rheumatoid arthritis	1.43E-07	 	 	 	 	ADM,SORL1,MME,APOE,SCAP,GADD45B,ZFP36,HSPA1A/HSPA1B,TNFAIP3,IL6,SIL1,CCL3,HLA-G,NR4A3,NFKBIA,CCL3L1,THBS1,S100A8,TXN,MCL1,PRNP,CCR1,HNMT,CD69,PLAUR,FOSB,GSR,FOS,F11R,NR4A2,S100A9,PTGS2,ANG	33	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	thyroid gland tumor	thyroid gland tumor	1.47E-07	 	 	 	 	SLIT3,HCAR3,CBX7,SVEP1,AXIN1,MAP6,CACNA1H,NOMO1 (includes others),ASCC2,ANKRD20A4 (includes others),POLRMT,MTX1,CLIP1,POR,TYSND1,IDUA,GATAD2A,NUP93,EIF3B,GLB1,POMZP3,RAB38,TSC2,CEP170B,PLXNB2,ETS1,RRP1,COMP,PODN,RAB3IL1,LAMC3,ZNF579,WDR81,AEN,MN1,NCF2,CTSB,C15orf39,CHD1L,mir-21,TRAPPC5,SLC4A2,CHCHD10,FGF2,ZNF205,GDF15,CDK4,THOC3,CKAP4,HS3ST3A1,RABL6,CHDH,NAXE,PGA5 (includes others),IRF2BPL,HCAR2,ATN1,FCGR3A/FCGR3B,FCER2,MAPKAP1,MECOM,GLRX2,RCCD1,THEM6,FOS,GPAM,ARHGEF5,NRXN2,KIF7,SERPINH1,TAGLN,LRRC75B,MAP3K8,BMPER,ABCC3,FOXRED1,SOCS3,TPPP3,C2CD4B,KIAA1551,PTTG1,RTN1,HSPA1A/HSPA1B,DPP7,ANKMY1,ZFPM1,AP1B1,C16orf91,INTS1,MYC,TGFBR2,ZNF598,TUBA1C,CHTF18,PDZRN3,KIF25,TEK,KMT5A,LRBA,MYDGF,ADAMTS1,MAN1C1,CLIP2,H6PD,THRA,KCNK12,AKR1B10,DCHS1,FAAP20,BCL2L1,ABCA8,ORM1,GIPC1,FAM26F,SOBP,IGFBP3,CAPN2,BAIAP2L2,C17orf97,RAB11FIP5,RBP4,SUN1,PMEPA1,POLR3F,FDX1L,SF3B5,ZP3,SCARA5,FLRT1,TPGS2,NEURL4,SLC2A3,IRAK1,HLA-DRB1,SH3PXD2B,EDN1,AHNAK,TIMP1,HES4,ISCU,ERBB2,VARS,MCRS1,GJA4,NLRP3,FAAP100,APBB1IP,ZNF358,SLC22A12,TUBG1,PWWP2B,PYGB,SAA2,CXCL16,CLGN,LOC102724788/PRODH,TACC2,IRF2BP2,PHF19,COL11A1,ING1,IVD,FCGBP,PRUNE2,DDX11,KCNK15,HRAS,CDKN2C,MST1,BCAS4,HOMER3,NR4A3,ITGA3,CLCNKA,SLC16A2,MED16,IRS2,PIK3C2B,SFRP4,PEX6,ARRDC4,RRBP1,PCSK5,TUBB2A,PLEC,MMP2,CEP89,PLOD1,CRABP1,FAM86B1,CORO7/CORO7-PAM16,CCDC170,ISLR,CCZ1/CCZ1B,ASGR1,CCND2,CDRT1,ADAMTS18,ASPHD2,MAP2K3,LRP8,ZER1,ITGA7,TMEM158,NOTCH1,BOD1,SUSD2,AKAP12,SPTBN1,ALDH4A1,FCGRT,SCAP,RCOR2,PFKL,TMEM259,ATP6AP1,TUSC5,C20orf96,IDH1,UCHL1,EFNB2,CES1,SRGAP1,CST3,ANXA5,DAP3,SLC19A1,PRKCE,SH3GLB2,TPO,RASSF5,AHNAK2,FUK,RNF135,SF3A2,PI4KA,PLXNA1,ANKRD9,ARHGAP4,BHLHE22,WDR18,AXL,GABRE,YBX2,RHPN2,FAM86C1,RBM42,RBM6,SBF1,LIMS1,SLC25A19,DENND1A,UAP1L1,ZSCAN18,S1PR1,ALS2CL,PTGS2,FBN2,PHLDA1,TFF3,ADSSL1,C10orf54,TNFRSF4,DCAKD,PTPN23,UNC5B,MAP1B,CLEC3B,SDC4,FAM173A,TSEN54,DHTKD1,GPC1,LTBR,RET,PDK4,MT1G,CRISPLD2,STAG3L2/STAG3L3,TRIOBP,SPP1,MTURN,PCDHA1,UBXN11,TPSAB1/TPSB2,FLCN,KIAA0922,PANK1,SORD,CCDC184,LRRC41,PKD1,RAP1GAP,FRYL,CUEDC1,SCRIB,C2orf40,ADAMTSL2,CLCN7,LSM7,AK2,AKR1B1,RNPEP,AMY1C (includes others),ADAMTS7,SFRP2,ATF5,PRDX5,PKM,CDH23,RARRES1,SMPD1,MAN1B1,PTPRF,TMEM119,ADSL,CSPG4,THBS1,ARHGEF35,KIT,ARHGEF2,EXOSC7,CTDNEP1,MYO16,ADRB2,RHBDD3,TMEM132B,RAB11FIP3,FRMD1,BHLHE41,CXCR4,PARP10,RNF126,SCIN,DHX37,CSF1R,FIZ1,NDUFA13,PLBD2,URM1,PLEKHH1,LRP1B,FAM46A,EPHB3,CPZ,ZNF585A,ELK1,KDR,MYPOP,DSG2,XK,CLEC10A,ALG1L,MMP9	354	
Cardiovascular Disease	infarction	Infarction	1.48E-07	 	-1.222	 	-0.800	HCAR3,APOB,KCNJ2,SH3GLB1,C1QA,IL6,CYBA,TSC2,CAV1,TXN,UNG,GUCY1A3,TUBB2A,THBD,VKORC1,NCF2,LRP8,COL3A1,APOE,FGF2,GDF15,ADIPOQ,TGM2,CCL3L3,PDE3B,CST3,ANXA5,PRKCE,STIM1,ADORA1,ABCC9,HCAR2,FCGR3A/FCGR3B,PLAT,GSTM1,UCP2,EGR1,GABRE,GRN,PLA2G4A,LDLR,PROCR,FCER1G,PTGS2,ADRA1A,CYP2C8,MAOA,SESN2,CD36,CXCL12,CD163,NNMT,PADI4,GPX3,MAP2K2,PLA2G5,SIAH2,TUBA1C,GCLM,GSK3B,ADRA1B,ACTA1,PTX3,CSF3R,MIF,NOX4,MYDGF,THRA,PTGDS,BCL2L1,ITGAM,NOL3,ADRA2A,CD14,MDK,ESR1,LEP,KCNK3,PPP1R1A,QPRT,TNFAIP3,HIF1A,NGF,TNFRSF12A,HMOX1,CD55,NFKBIA,EDN1,TIMP1,RPS6KB2,MAPKAPK2,AGT,PRNP,ADRB2,SRC,RNLS,CXCR4,ATP2C1,TUBG1,F13A1,CSF1R,RCAN1,CAPNS1,C6,P2RX7,MMP9	106	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of tumor cell lines	1.54E-07	 	-1.746	 	-3.520	PHLDA1,TFF3,CD4,CXCL12,HRAS,IL6,NEU1,PARVB,ITGA3,MAP2K2,ST6GALNAC2,CAV1,VEGFD,AFAP1,C1QBP,LTBR,RASGRP2,ETS1,FERMT3,ELN,CXCL8,SFRP4,SELE,SPP1,VEGFC,MMP2,JUNB,THBD,HAX1,INHBB,CDH2,ERP29,ITGAM,BSG,RAP1GAP,SNX1,CTSB,ALCAM,MAPK7,CYR61,NOTCH1,VHL,mir-21,S100P,ETV5,AKAP12,APOE,NME1,ADAM17,LEP,GDF15,PKM,INPPL1,CCL3,VCAN,UCHL1,TGM2,CD55,NFKBIA,JUN,CCL2,NET1,THBS1,DKK3,FLNA,SRGN,RHOU,DAB2,PI4KB,EMILIN1,SRC,VCAM1,CD59,PARVA,MECOM,TJP1,CXCR4,EGR1,CSK,HYAL1,PLAUR,SLIT2,FOS,RCAN1,F11R,CYTIP,MAP3K8,CXCL2,DSG2	89	
Neurological Disease	seizures	seizures	1.61E-07	Decreased	-2.096	bias	0.161	SNTA1,TYRO3,CA5B,CACNA1H,CA12,C1QA,IL6,C1QB,SLC9A1,NR4A3,SLC4A3,EGR2,GLB1,NPTX2,MCL1,PIGT,CALCRL,ATG7,SV2B,CHN1,JUNB,NPY5R,HSPA8,SH3GL1,MS4A4A,ATOX1,CYR61,ADM,GADD45B,ZFP36,FGF2,GNA11,HYOU1,SLC1A3,MIR22HG,ADIPOQ,CEBPD,HEXA,TGM2,TRIB1,CA3,DTNA,DUSP5,MTOR,JUN,GADD45A,PNPO,TIPARP,ALDH5A1,ATN1,NAPB,PLAT,CCR1,EGR1,ANOS1,RGS16,GFRA2,GABRE,CSTB,FOS,LDLR,RNF144A,SPRY2,ATP1A2,DBNL,TPP1,PTGS2,SYN2,CH25H,RGS1,SOCS3,NCDN,CYTOR,CA4,HSPA1A/HSPA1B,MAP1B,TUBB,MYC,CTSD,IKBKG,AMPH,CLCN3,ATF3,CYYR1,ACP2,IER2,EGR3,UNC13B,FZD9,LMCD1,FOSB,DUSP1,SYN1,--,GDI1,LEP,SLC2A3,HMOX1,ANGPTL4,SRGN,MICALL1,IFRD1,CRYM,ALPL,CXCR4,C9orf3,SLC12A2,PCOLCE2,PLAUR,AP3B2,SERTAD1,SERPINE2,PMP22,AP3M2,GAP43,MMP9	116	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of antigen presenting cells	1.62E-07	 	0.667	 	-1.420	CTGF,CTSG,MST1,HRAS,HOXA9,ABCC1,CAV1,TNFRSF21,SELE,CMKLR1,NDRG1,PLEC,ANO6,THBD,NINJ1,S1PR3,PPP1R15A,IL10RA,CD86,ALCAM,ITGA1,PLTP,CYR61,CNN2,APOE,ADAM17,NQO2,ACKR2,ADIPOQ,G6PC3,VCAN,CES1,GBA,CCL2,CCL3L3,ADORA1,HCAR2,IL11RA,CCR1,CD209,C5AR1,TYROBP,DEFB1,SLIT2,PLA2G4A,SWAP70,LDLR,WAS,S1PR1,MAP3K8,PTGS2,PFN1,RARRES2,CXCL12,HARS,TGFBR2,NARS,IKBKG,RHOB,CXCL14,STAB1,MARCO,PTX3,CXCL8,ELN,MIF,SPP1,PTGDS,APBA3,STC1,PRKCD,MDK,LITAF,SFTPD,LEP,ABL1,TNFAIP3,MYLK,HIF1A,CCL3,HMOX1,EDN1,FLNA,THBS1,TIMP1,SAA1,DUSP10,KIT,ERBB2,MAPKAPK2,AGT,PRNP,EPAS1,NLRP3,MMP28,CXCR4,NQO1,PCOLCE2,SMAD7,LRRK2,CSF1R,C6,KDR,P2RX7	104	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	urinary tract cancer	urinary tract cancer	1.67E-07	 	0.074	 	0.314	CBX7,SLC6A9,PCLO,VAC14,TPRG1,POLRMT,SLC39A8,POR,UPK3BL,CCND3,AJUBA,GLB1,TSC2,SMARCB1,DEFB132,WASH3P,PTGIS,SLC2A5,RANBP3,LARP4,PTPN3,PDLIM7,CDH5,KIAA1217,EPHX1,CD163L1,PSMD7,MFSD5,MECOM,PDZD2,AFF3,HNRNPH1,GCNA,SOX9,ARSD,DIRAS1,GPC3,INTS1,LHFPL2,TUBA1C,BIRC3,TEK,MARCO,CXCL8,H19,STK39,ERCC2,GUF1,FAAP20,BCL2L1,AEBP2,RPL8,BAP1,C17orf97,VHL,SUN1,RPH3AL,SH3PXD2B,ERBB2,NSFL1C,G6PD,PLAUR,PYGB,POLR3B,RRAS2,TSC22D1,CXCL2,PRUNE2,DDX11,MSRB2,PCDH17,MST1,ZNF605,PRG4,KIF21A,PIK3C2B,BIRC7,ZC3HC1,CENPB,THBD,NINJ1,FAHD2B,CCDC136,SH3GL1,FAM86B1,CCZ1/CCZ1B,EPB42,CCT3,ALAS2,NOTCH1,TMEM158,SERAC1,BTG3,FKBP1A,TBL3,ATP6AP1,CADM2,JUN,CD24,COL22A1,AHNAK2,NPRL2,GJB2,CD209,PLXNA1,CD276,SLIT2,AXL,EMC1,TRMT12,GABRE,LMO3,SBF1,TMEM63B,PTGS2,ATAD3A,ZFYVE19,SPNS1,CLEC3B,SLC35F1,GUSB,ZNF91,METAP2,GSPT1,ETS2,COMT,ACP6,MCTP1,RET,STX11,MFSD3,FERMT3,ACSL3,TRIOBP,EGR3,ALAD,NDUFAF2,GPAA1,INHBB,TPSAB1/TPSB2,FLCN,COL6A3,RAP1GAP,PRKCD,SCRIB,LMAN2L,XPNPEP1,CDK5RAP2,NFKBIA,THBS1,ASAP3,CHEK2,ZNF493,EMILIN1,LXN,TPST2,PHLDA3,LRRK2,ACAT1,GLMP,GBE1,KDR,XK,SLC47A1,DHRS7B,SYTL2,PLEKHM2,CLIP1,ODC1,NPL,KEAP1,ARHGAP39,CAV1,TSHZ2,PIGT,TM6SF1,STK36,PPP1R1B,CARMIL1,IFNAR2,TFPI2,SHROOM4,MN1,NRDE2,BTG2,PPP1R15A,GCC1,ZDHHC1,NME1,OSGIN1,FGF2,CUBN,IGSF1,CDK4,CTDSPL,LAMP3,MRPL22,CCL2,POFUT2,ARFGAP1,PLIN2,IL34,ADORA1,RAD21,ALDH5A1,CYP51A1,S100A1,CCR1,TJP1,DGAT2,ARHGEF5,FOS,FLNC,ATP1A2,MBD3,TAF1C,MAP3K8,RBP5,C11orf68,BMP6,CPXM1,HAGH,QPCT,ATP2B1,SESN2,ABCA3,MBP,KLF6,HSPA1A/HSPA1B,MYC,TGFBR2,RHOB,MOCOS,GIMAP5,KIF25,LRBA,ATF3,RILPL1,MAST4,UNC13B,SRPRB,LAMA2,VEGFC,DCHS1,FOSB,SDCBP,IGFBP3,ESR1,S100P,RUNX1,PTGFR,SLC1A4,HNRNPK,GSTT1,IRAK1,POLR1C,RPL14,HLA-DRB1,AHNAK,TIMP1,SAA1,LOC102724428/SIK1,LRPPRC,NUSAP1,NQO1,TUBG1,GNAI1,ATIC,CXCL16,HEPACAM,SMG7,CDC34,NNAT,SLC29A4,MIB2,WDR45,CDKN2C,HRAS,LPIN1,ANK2,IRS2,CALCRL,NANOS1,TUBB2A,MMP2,RAE1,SRGAP3,AQP9,TIMP4,CCND2,BSG,NPRL3,IL10RA,CDRT1,TRO,ADM2,RPL6,MAP2K3,RSU1,SFRP1,MAPK7,AIDA,CYR61,PHLPP1,SPTBN1,MME,ADM,HIST1H1C,ADAM17,RALA,XPOT,TNFSF10,IDH1,UCHL1,TRIB1,MTOR,ANXA5,PRKCE,PTPRT,MBOAT7,PLAT,GSTM1,MYCN,TWNK,MGMT,DEFB1,COL5A3,MRPL51,KRT8,MCM2,TF,PPP1R16B,NOP2,CHFR,BNIP3L,GABARAP,ZFP36L2,FBN2,RGS1,NAGK,CXCL12,XPO5,IL17RC,TPM1,ARG2,TUBB,ASXL2,SIAH2,PUF60,FAM65B,PDK4,AXIN2,SPP1,NUP155,PANK1,PPP2R1A,PKD1,SMOX,RRP7A,RGN,TMOD1,MAP2K5,RNPEP,ADAMTS7,PKM,CDH23,ABL1,HIF1A,ACOT7,FAM110B,EPHB6,HMOX1,PCK2,FLNA,KCNMA1,CSPG4,FUBP3,KIT,CUL9,TMEM132B,ASIP,FAAH,SNAPC4,FRMD1,AP3D1,SMAD7,ZBTB7C,NFKBIZ,CSF1R,LPAR1,TSPAN1,MMP9	392	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of connective tissue cells	1.68E-07	 	1.036	bias	-0.651	BMP4,CTGF,CD4,TGFBR3,CXCL12,HRAS,SDC4,IL6,DRG2,RHOB,ITGA11,VEGFD,SPP1,PLEC,VEGFC,THY1,LAMC3,THRA,MMP2,CDH2,ITGAM,TLN2,CYR61,TMOD1,COL7A1,ADM,RUNX1,AKAP12,MME,SLC4A2,LTBP2,FGF2,BMP2,ATAT1,RAMP2,EFNB2,IPO9,CCL2,RHOD,TNMD,AGT,SRC,VCAM1,MECOM,CSK,PLAUR,IGF2R,BTK,COL1A1,PMP22,MYOC,LDLR,SPARC	53	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	malignant neoplasm of endocrine gland	malignant neoplasm of endocrine gland	1.70E-07	Increased	2.611	 	2.656	PRUNE2,CBX7,AXIN1,WBSCR22,CDKN2C,HRAS,ASCC2,IL6,ODC1,POR,ITGA3,NUP93,TSC2,ETS1,PEX6,SELE,TUBB2A,LAMC3,MMP2,IFNAR2,CRABP1,CORO7/CORO7-PAM16,CCND2,ZER1,NOTCH1,mir-21,SPTBN1,MME,FCGRT,ZFP36,FGF2,GDF15,CDK4,FKBP1A,IDH1,EFNB2,MTOR,SRGAP1,DAP3,PRKCE,TPO,HGS,GSTM1,MYCN,MAPKAP1,ARHGAP4,SLIT2,AXL,RBM42,S1PR1,MAP3K8,PTGS2,ABCC3,SOCS3,TFF3,RTN1,PTTG1,UNC5B,ANKMY1,MYC,TGFBR2,TUBA1C,PDCD6,RET,TEK,PDK4,CSF3R,SPP1,ADAMTS1,CLIP2,THRA,GALNT13,FLCN,BCL2L1,PKD1,RAP1GAP,LSM7,VHL,AMY1C (includes others),SFRP2,BMP2,PKM,FLRT1,ABL1,AHNAK,KCNMA1,THBS1,TIMP1,KIT,CDCA5,ARHGEF2,ERBB2,TMEM132B,GJA4,VCAM1,CXCR4,TUBG1,CSF1R,NDUFA13,CXCL16,CLGN,COL11A1,ELK1,KDR,XK,DSG2,MMP9,FCGBP	108	
Neurological Disease	neurological signs	neurological signs	1.73E-07	 	-0.545	 	-0.192	CTGF,AHCYL1,SGK1,CA12,ZNF239,HRAS,PCDH7,GHITM,SERPINA3,IL6,ATP2A2,MT1E,EGR2,GPRC5C,PPRC1,NPTX2,PNKD,CAV1,VEGFD,TXN,PKIA,CASQ2,AHCY,POLR2I,FBL,CDKN1C,DBP,NDRG1,COCH,CHN1,PPP1R1B,MT1X,PTPN3,JUNB,IER3,NGRN,HSPA8,MAP3K12,CDH2,PDLIM7,NR1D1,CD68,PDE1B,GAPDH,SLC27A1,LRP8,EIF3K,MME,SORL1,APOE,NME1,NDUFA7,DDIT3,GBP1,SRD5A1,FGF2,SCUBE2,SLC1A3,KAZN,THBS3,CORO2B,VCAN,UCHL1,TGM2,DTNA,DUSP5,STOM,MTOR,JUN,GBA,MAL2,GADD45A,CYP51A1,MLF2,MYOM2,EGR1,NBEA,SLIT2,PSMB6,ID3,GABRE,MYO5A,FOS,F11R,GPAM,HP,LAMP2,LDLR,NTRK3,UQCR10,ADCY1,S1PR1,FKBP4,SOX9,ID4,ADRA1A,MT2A,FAM136A,SERPINI1,PFN1,PFKFB1,ATP2B1,CD36,HSPA1A/HSPA1B,MT1M,DNAJB2,SDC4,DYNLT1,HSPA5,FAM173A,CYP26B1,AK1,STRN4,KCNAB1,ADRA1B,RASGRP2,MT1G,APLNR,ICA1,LMCD1,FOSB,BCL2L1,ITGAM,ADRA2A,RAP1GAP,C2orf40,RARRES3,IDO1,NDUFS3,RBP4,ETV5,SRM,FAM107A,SH3BP4,LEP,SLC1A4,SRPX,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,EMX2,GTF3A,NGF,ALDH2,HMOX1,RAB5A,AEBP1,DHCR7,SUCLA2,HINT1,DKK3,KCNMA1,MT1L,C7,MICALL1,CRYM,ACADM,ADRB2,PRNP,PSAT1,SMAD6,DAAM2,SGTA,PLSCR4,NDUFA13,RCAN1,PMP22,KCTD13,CAPNS1,VAMP1,CYC1,ACAT1,UQCRC1,NREP,XK,ATP6V1B2	178	
Cancer, Organismal Injury and Abnormalities	neck neoplasm	neck neoplasm	1.90E-07	 	 	 	 	SLIT3,HCAR3,CBX7,SVEP1,AXIN1,MAP6,CACNA1H,NOMO1 (includes others),ASCC2,ANKRD20A4 (includes others),IL6,POLRMT,MTX1,CLIP1,POR,TYSND1,IDUA,GATAD2A,NUP93,EIF3B,GLB1,POMZP3,RAB38,TSC2,CEP170B,PLXNB2,ETS1,RRP1,COMP,PODN,RAB3IL1,LAMC3,ZNF579,WDR81,AEN,MN1,NCF2,CTSB,C15orf39,CHD1L,mir-21,TRAPPC5,SLC4A2,CHCHD10,FGF2,ZNF205,GDF15,CDK4,THOC3,CKAP4,HS3ST3A1,RABL6,CHDH,NAXE,PGA5 (includes others),IRF2BPL,HCAR2,ATN1,FCGR3A/FCGR3B,FCER2,MAPKAP1,MECOM,GLRX2,RCCD1,THEM6,FOS,GPAM,ARHGEF5,NRXN2,KIF7,SERPINH1,TAGLN,LRRC75B,MAP3K8,BMPER,ABCC3,FOXRED1,SOCS3,TPPP3,C2CD4B,KIAA1551,AKR1C3,PTTG1,RTN1,HSPA1A/HSPA1B,DPP7,ANKMY1,ZFPM1,AP1B1,C16orf91,INTS1,MYC,TGFBR2,ZNF598,TUBA1C,CHTF18,PDZRN3,KIF25,TEK,KMT5A,LRBA,MYDGF,ADAMTS1,MAN1C1,CLIP2,H6PD,THRA,KCNK12,AKR1B10,DCHS1,FAAP20,BCL2L1,ABCA8,ORM1,GIPC1,FAM26F,SOBP,IGFBP3,CAPN2,BAIAP2L2,C17orf97,RAB11FIP5,RBP4,SUN1,PMEPA1,POLR3F,FDX1L,SF3B5,ZP3,SCARA5,FLRT1,TPGS2,NEURL4,SLC2A3,IRAK1,HLA-DRB1,SH3PXD2B,EDN1,AHNAK,TIMP1,HES4,ISCU,ERBB2,VARS,MCRS1,GJA4,NLRP3,FAAP100,APBB1IP,ZNF358,SLC22A12,TUBG1,PWWP2B,PYGB,SAA2,CXCL16,LOC102724788/PRODH,CLGN,TACC2,IRF2BP2,PHF19,COL11A1,ING1,IVD,FCGBP,PRUNE2,DDX11,KCNK15,HRAS,CDKN2C,MST1,BCAS4,HOMER3,NR4A3,ITGA3,CLCNKA,SLC16A2,MED16,IRS2,PIK3C2B,SFRP4,PEX6,ARRDC4,RRBP1,PCSK5,TUBB2A,PLEC,MMP2,CEP89,PLOD1,CRABP1,FAM86B1,CORO7/CORO7-PAM16,CCDC170,ISLR,CCZ1/CCZ1B,ASGR1,CCND2,CDRT1,ADAMTS18,ASPHD2,MAP2K3,LRP8,ZER1,ITGA7,TMEM158,NOTCH1,BOD1,SUSD2,AKAP12,SPTBN1,ALDH4A1,FCGRT,SCAP,RCOR2,PFKL,TMEM259,ATP6AP1,TUSC5,C20orf96,IDH1,UCHL1,EFNB2,CES1,SRGAP1,CST3,ANXA5,DAP3,SLC19A1,PRKCE,SH3GLB2,TPO,RASSF5,AHNAK2,FUK,RNF135,SF3A2,PI4KA,PLXNA1,ANKRD9,ARHGAP4,BHLHE22,WDR18,AXL,GABRE,YBX2,RHPN2,FAM86C1,RBM42,RBM6,SBF1,LIMS1,SLC25A19,DENND1A,UAP1L1,ZSCAN18,S1PR1,ALS2CL,PTGS2,FBN2,PHLDA1,TFF3,ADSSL1,C10orf54,TNFRSF4,DCAKD,PTPN23,UNC5B,MAP1B,CLEC3B,SDC4,FAM173A,TSEN54,DHTKD1,GPC1,LTBR,RET,PDK4,MT1G,CRISPLD2,STAG3L2/STAG3L3,TRIOBP,SPP1,MTURN,PCDHA1,UBXN11,TPSAB1/TPSB2,FLCN,KIAA0922,PANK1,SORD,CCDC184,LRRC41,PKD1,RAP1GAP,FRYL,CUEDC1,SCRIB,C2orf40,ADAMTSL2,CLCN7,LSM7,AK2,AKR1B1,RNPEP,AMY1C (includes others),ADAMTS7,SFRP2,ATF5,PRDX5,PKM,CDH23,RARRES1,SMPD1,MAN1B1,PTPRF,TMEM119,ADSL,CSPG4,THBS1,ARHGEF35,KIT,ARHGEF2,EXOSC7,CTDNEP1,MYO16,ADRB2,RHBDD3,TMEM132B,RAB11FIP3,FRMD1,BHLHE41,CXCR4,PARP10,RNF126,SCIN,DHX37,CSF1R,FIZ1,NDUFA13,PLBD2,URM1,PLEKHH1,LRP1B,FAM46A,EPHB3,CPZ,ZNF585A,ELK1,KDR,MYPOP,DSG2,XK,CLEC10A,ALG1L,MMP9	356	
Molecular Transport, Protein Trafficking	transport	transport of protein	1.94E-07	 	1.648	bias	0.148	RAB3IP,ASPSCR1,BMP4,AKR1C3,AHCYL1,SNX8,ITGB1BP1,MBP,MAP1B,RAN,XPO5,AP1B1,DYNLT1,AP2A2,NSF,PEX16,EGR2,RHOB,CSE1L,TSC2,CAV1,KPNA2,PDCD6,GSK3B,TEK,VIPAS39,CALCRL,MGRN1,PEX6,NUP155,TIMM44,PEX7,HSPA9,HSPA8,TNPO2,CTSA,ARF5,ERP29,PKD1,PRKCD,SNX1,COMMD1,AGAP3,RAMP3,LMAN2L,SQSTM1,SLC11A1,XPO6,VHL,TOMM40,SPTBN1,LEP,ZP3,TPR,VAPA,RAMP2,GPIHBP1,IFI27,IPO9,SNX16,NFKBIA,JUN,LLGL1,ARFGAP1,RANGAP1,SMO,CHCHD4,HGS,ADRB2,SRC,VPS18,AP2M1,AP3D1,TMED2,AP3B2,TOB1,TIMM23,SNX27,IGF2R,ZPR1,RUFY1,COL1A1,EXOC4,IPO13,LRP1B,POLA2,ING1,GABARAP,SCAMP3,GAPVD1	90	
Cellular Function and Maintenance	receptor-mediated endocytosis	receptor-mediated endocytosis	2.10E-07	Increased	2.771	bias	0.751	SORL1,APOE,SFTPD,ATP6V1D,ITSN1,SCARA5,CUBN,ACKR2,ANTXR1,LRRC29,AP2A2,SF3B3,ATP6AP1,HNRNPK,NKAP,ASB1,TGFBR2,CAV1,NAA60,MICALL1,STAB1,DAB2,ERBB2,LDLRAP1,ADORA1,HGS,PI4KB,ADRB2,EPN1,AP2M1,SHARPIN,CANX,RPS21,IGF2R,HAX1,AP2S1,ATP6V1E1,SRSF3,ASGR1,LDLR,PDLIM7,ATP6V1F,SCARA3,TF,PIP5K1C,APOC1,CD14,LRP8,EPB41L2,ATP6V1B2	50	
Cardiovascular System Development and Function	morphogenesis	morphogenesis of cardiovascular system	2.16E-07	 	-0.059	bias	-1.291	APOB,BMP4,TGFBR3,ZFPM1,TPM1,ODC1,RHOB,ASXL2,GAA,HEY2,FZD2,MYL3,PIK3C2B,CXCL8,HEYL,PKP2,MMP2,NPY5R,DCHS1,FOXC1,STC1,DVL2,CDH2,ALDH1A2,MAP2K3,MAPK7,CYR61,ITGA7,TMOD1,NOTCH1,NRP1,APOE,SFRP2,FGF2,BMP2,CFC1/CFC1B,FLRT2,CLUAP1,FKBP1A,HIF1A,NGF,SOX17,COL5A1,EFNB2,ID1,MTOR,JUN,EDN1,THBS1,FLNA,SOS1,SMO,MKL2,LY6E,TNMD,CSNK2B,COL18A1,PLOD3,HEY1,VCAM1,DHRS3,MECOM,ANGPT1,MESP1,SMAD7,TMED2,CYP1B1,COL1A1,ZFPM2,CLDN5,DVL3,COL11A1,KDR,CXCL2,CHD7	75	
Neurological Disease	dyskinesia	dyskinesia	2.19E-07	 	-1.446	 	-1.264	CTGF,AHCYL1,SGK1,CA12,ZNF239,HRAS,PCDH7,GHITM,SERPINA3,IL6,ATP2A2,MT1E,EGR2,GPRC5C,PPRC1,NPTX2,PNKD,CAV1,TXN,PKIA,CASQ2,AHCY,POLR2I,FBL,CDKN1C,DBP,NDRG1,COCH,CHN1,PPP1R1B,MT1X,PTPN3,JUNB,IER3,NGRN,HSPA8,MAP3K12,CDH2,PDLIM7,NR1D1,CD68,PDE1B,GAPDH,SLC27A1,EIF3K,SORL1,APOE,NME1,NDUFA7,DDIT3,GBP1,SRD5A1,FGF2,SCUBE2,SLC1A3,KAZN,THBS3,CORO2B,VCAN,UCHL1,TGM2,DTNA,DUSP5,STOM,JUN,MAL2,GADD45A,CYP51A1,MLF2,MYOM2,EGR1,NBEA,SLIT2,PSMB6,ID3,GABRE,MYO5A,FOS,F11R,GPAM,HP,LAMP2,LDLR,NTRK3,UQCR10,S1PR1,FKBP4,SOX9,ID4,ADRA1A,MT2A,SERPINI1,PFN1,PFKFB1,ATP2B1,HSPA1A/HSPA1B,MT1M,DNAJB2,SDC4,DYNLT1,HSPA5,FAM173A,CYP26B1,AK1,STRN4,KCNAB1,ADRA1B,RASGRP2,MT1G,APLNR,ICA1,LMCD1,FOSB,BCL2L1,ITGAM,ADRA2A,RAP1GAP,C2orf40,RARRES3,IDO1,NDUFS3,RBP4,ETV5,SRM,FAM107A,SH3BP4,LEP,SLC1A4,SRPX,PPP1R1A,FLRT2,PCMT1,PKM,PPP1CB,EMX2,GTF3A,NGF,ALDH2,HMOX1,RAB5A,AEBP1,DHCR7,HINT1,SUCLA2,DKK3,KCNMA1,MT1L,C7,MICALL1,CRYM,ACADM,ADRB2,PSAT1,SMAD6,DAAM2,SGTA,PLSCR4,NDUFA13,RCAN1,PMP22,KCTD13,CAPNS1,VAMP1,CYC1,ACAT1,UQCRC1,NREP,XK,ATP6V1B2	169	
Cellular Assembly and Organization	growth	growth of plasma membrane projections	2.50E-07	Increased	2.336	 	-0.208	CAMK1,BMP4,SGK1,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,TSC2,CAV1,DLG4,DNAJA3,TXN,TESK1,MATK,RND2,RIMS3,CHN1,PRAG1,GRK5,MMP2,TNK2,NINJ1,DOCK1,DVL2,SRGAP3,CDH2,RTN4,ITGA1,MAPK7,NOTCH1,PTPRA,NRP1,SPTBN1,FYN,APOE,ADAM17,PLXNA3,BTG3,FGF2,DCLK1,VTI1B,VCAN,EIF4EBP1,TGM2,EFNB2,MTOR,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,EGR1,GFRA2,SLIT2,RELN,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,MAOA,MT2A,SOCS3,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,BRSK1,GSK3B,NEDD4L,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,NGF,PTPRF,TNFRSF12A,SHC1,NFKBIA,ARHGAP17,STUB1,TIMP1,THBS1,MARCH8,DUSP10,USP47,KIT,ENPP2,NSMF,PRNP,SRC,VCAM1,PAK4,EPN1,RTKN,SLC12A2,LRRK2,ZPR1,SERPINE2,FAIM,KIF2A,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,TNFRSF19,MMP9	136	
Cellular Assembly and Organization, Cellular Function and Maintenance, Tissue Development	formation	formation of actin stress fibers	2.54E-07	 	1.078	 	-0.560	BMP4,PFN1,CTGF,ITGB1BP1,CXCL12,RGCC,HRAS,TPM1,SDC4,SLC9A1,ITGA3,ADGRF5,BOP1,RHOB,GPR4,KANK3,CAV1,KLF2,TESK1,ELN,CXCL8,NOX4,MIF,SELE,GNG2,CARMIL1,THY1,MMP2,JUNB,HAX1,UBXN11,LMCD1,CDC42BPB,PTPRA,FYN,LEP,FGF2,GNA11,CDK4,MYLK,MYH11,PHLDB2,MTOR,EDN1,CCL2,NET1,SORBS1,RHOD,STARD13,DAB2,PRKCE,ARHGEF2,PIK3R2,GNG5,COL18A1,ASAP3,ADORA1,NCKIPSD,PTGER4,PLAT,AGT,SRC,VCAM1,PAK4,RTKN,ARHGEF5,KCTD13,MYOC,LPAR1,SPRY2,S1PR1,EDNRA,SPARC,KDR	74	
Amino Acid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of amino acids	2.59E-07	 	0.395	bias	-0.863	ADSSL1,ASS1,CXCL12,PCCB,ARG2,IL6,PYCR2,GSS,MYC,CNDP2,BCAT2,COMT,SLC7A5,ATF4,GOT1,GCLM,BCKDK,NOX4,ATG7,GLYAT,GAMT,SLC22A5,SLC7A2,CSAD,ME2,GLUL,CD86,IDO1,PYCR1,DDAH2,LEPR,PKM,SLC1A3,ME1,ASNS,VCAN,GFPT2,PEPD,CS,PTS,SLC25A15,GOT2,ALDH5A1,SLC7A6,BLMH,EGR1,HDC,CDO1,SLC7A8,CBS/CBSL,GCSH,MSRA,IVD,SHMT2	54	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of lymphocytes	2.92E-07	 	-0.988	bias	-3.343	CTSG,HRAS,IL6,SGPL1,ITGA3,EGR2,ABCC1,MYADM,TNFRSF21,ETS1,CMKLR1,SELE,PLEC,S1PR3,PIP5K1C,CD86,ITGA1,MAPK7,PTPRA,NOTCH1,FYN,ADAM17,NQO2,GNA11,ACKR2,HYOU1,TNFSF10,TGM2,JUN,CCL2,CCL8,CCL3L3,SOS1,RASSF5,PIK3R2,GJB2,CCR1,CD209,UCP2,CD69,HDC,RGS16,DEFB1,PVR,GPR183,FOS,F11R,SWAP70,LDLR,WAS,PELI1,PROCR,S1PR1,PTGS2,NEDD9,RGS1,SOCS3,RARRES2,TNFRSF4,CD4,SPHK2,CXCL12,FCER1A,HARS,TGFBR2,CYP26B1,IKBKG,STAB1,LTBR,FAM65B,KLF2,FERMT3,CXCL8,MIF,SPP1,GNAZ,EFS,RAP1GAP,PRKCD,CCL18,ESR1,RUNX1,AOC3,LEP,MYLK,SMPD1,CCL3,ETV6,HLA-G,HMOX1,SHC1,NFKBIA,CCL13,THBS1,TIMP1,SAA1,MCAM,ENPP2,ERBB2,AGT,VCAM1,NLRP3,CXCR4,NQO1,TNFRSF14,BTK,COL1A1,CXCL16,CYTIP,VAV3,SPARC,C6,KDR,P2RX7,MMP9	115	
Cell Death and Survival	apoptosis	apoptosis of colorectal cancer cell lines	3.00E-07	 	-1.406	 	-1.330	TFF3,GMDS,SGK1,AXIN1,COX8A,SPHK2,TRAP1,HRAS,AP2A2,MYC,PADI4,G0S2,AHSA1,CSE1L,GSK3B,HIPK2,MCL1,ETS1,BIRC7,MIF,CDKN1C,SPP1,ATF3,ATG7,NDRG1,PPP1R1B,TNFRSF10B,BCL2L1,TRIM39,PRKCD,PPP1R15A,ATMIN,IGFBP3,SQSTM1,TRIAP1,NOTCH1,PHLPP1,PMEPA1,RUNX1,ADAM17,LEP,DDIT3,DAPK2,FGF2,GDF15,PKM,ABL1,TNFSF10,NGF,DIABLO,TGM2,HINT1,RABL6,NFKBIA,EDN1,GADD45A,TIMP1,ERBB2,COL18A1,TRIM29,CHEK2,SRC,RTKN,SMAD7,IGF2R,NR4A2,NTRK3,LIMS1,MT1F,SPARC,SOX9,PTGS2,DSG2	73	
Cellular Development	differentiation	differentiation of cells	3.02E-07	 	0.917	 	-2.293	AXIN1,IL6,POR,CCND3,AJUBA,SMARCB1,TSC2,PLXNB2,TMBIM1,RRAGC,ETS1,TNFRSF21,FBL,SLC2A5,HEYL,RBM38,COCH,DDIT4,TMEM100,DVL2,PDLIM7,CDH5,CTSB,ALCAM,ACACA,mir-21,GADD45B,EIF4EBP2,DDIT3,SLC1A5,GNA11,ADIPOQ,SPON1,TIPARP,LLGL1,LY6E,ATN1,MECOM,ZNF521,CD69,MESP1,CDO1,IGF2R,ID3,MYO5A,KIF7,SWAP70,CBS/CBSL,PIR,LYN,SOX9,NDST2,SOCS3,RARRES2,AKR1C3,DPYSL4,HAVCR2,ZFPM1,NARFL,GPC3,CBX5,CPNE1,TEK,CXCL8,NOX4,STK39,RIMS4,GNAZ,ERCC2,TXNRD1,BCL2L1,H3F3A/H3F3B,CCDC80,VHL,UBE2I,ETV5,SULF1,ANGPTL8,BMP2,EMX2,HLA-G,DHCR7,SH3PXD2B,COL6A1,EDN1,ERBB2,SRC,NLRP3,PLAUR,KIF3B,BTK,RRAS2,FECH,SPARC,ITM2C,BMP4,CTGF,TYRO3,MST1,NR4A3,SGPL1,ITGA3,IRX3,MKX,RARA,MCL1,RND2,SFRP4,CMKLR1,NAB1,HBEGF,GRK5,JUNB,HMGA1,MBD2,CREB5,THBD,ROR1,BCAP29,MAP3K12,GDPD5,RTN4,ALAS2,NOTCH1,ANG,NRP1,CNN2,FYN,ZFP36,BTG3,LEPR,SIN3B,SLC1A3,ATAT1,GPC4,H2AFZ,ATP6AP1,EIF4EBP1,MAFG,KLF9,CES1,KAT2B,JUN,CST3,CSF2RA,ACVR1C,ABHD5,CD276,EGR1,BHLHE22,SLIT2,ACLY,AXL,RELN,LMO3,SBF1,TENM4,BRINP2,PTGS2,MAMSTR,CHD7,ARID4A,PRPF19,TNFRSF4,PFN1,FARP1,CD36,CD4,MAP1B,UNC5B,TBX15,H2AFY2,ETS2,ACP6,DHTKD1,GSK3B,GPC1,C1QBP,RET,FZD2,PTPRE,FST,EGR3,FZD9,MAPK8IP3,RASD1,TPSAB1/TPSB2,UBXN11,FLCN,ATPIF1,RAP1GAP,PRKCD,RARRES3,CD14,CDK5RAP2,--,SMAP1,SFRP2,PA2G4,ATF5,NGF,PTPRF,NFKBIA,THBS1,DUSP10,HSPE1,SMO,IFRD1,SULF2,ACADM,ADRB2,BEX2,PAK4,EPAS1,BHLHE41,ATP2C1,ANKRD54,LRRK2,EDF1,PRMT1,NCAPH2,EMP1,FAF1,KIF2A,EBF1,EPHB3,NUCB2,GAP43,KDR,NCKAP1L,CSTA,HLA-DOA,HACD1,CTSG,C1QC,SPI1,ATP2A2,SLC9A1,ODC1,NKAP,EGR2,GNA15,MCOLN3,KEAP1,LUM,MGP,CAV1,DLG4,ATF4,EBF2,HES6,HIPK2,KAT2A,PIGT,SELE,PPP1R1B,TNFRSF10B,MAD2L2,RHBDD1,HAX1,CARD9,EVPL,MN1,FSCN1,PPP1R15A,BTG2,GAPDH,TFRC,CD86,SQSTM1,BYSL,PTPRA,APOE,NME1,FGF2,CEBPD,CDK4,CTDSPL,CTHRC1,TGM2,DUSP5,CCL2,IL17D,IL34,SOS1,OSBPL11,DAB2,CSNK2B,PIK3R2,ADORA1,HEY1,CCR1,SIGMAR1,SPRY1,TOB1,TRIB3,HSPA2,GLG1,GRN,MMD,FOS,PLA2G4A,ZFPM2,MYOC,NR4A2,LDLR,NTRK3,FLNC,TAGLN,NLE1,BMPER,PIN1,BMP6,ID4,ADRA1A,MT2A,NOC3L,PTTG1,ITGB1BP1,MBP,HSPA1A/HSPA1B,PARP2,HSPA5,BIN1,MYC,TGFBR2,NNMT,ADGRF5,RHOB,CXCL14,CAST,ATF3,IER2,LAMA2,BTG1,VEGFC,THRA,PTGDS,KLF4,SLC3A2,OGN,CBX1,NOL3,DUSP1,ALDH1A2,HIF1AN,IGFBP3,FZD5,MDK,ESR1,TXNRD2,MAST2,RUNX1,DOK5,PTGFR,FAM107A,NMT1,FRZB,MPZL2,PTPMT1,AUP1,CADPS2,ATF6,CCL3,HNRNPK,ETV6,CIAPIN1,SHC1,TIMP1,MKL2,RNH1,ENPP2,IARS,LONP1,AGT,AP1S2,SMAD6,ZNF16,BSCL2,NFE2L1,SERPINE2,SH3PXD2A,PMP22,CAPNS1,PHF19,KIF5B,CAT,RPS6KA4,DNM1L,NREP,PNPLA6,CAMK1,ITSN1,SGK1,TGFBR3,MAF,HRAS,CDKN2C,RAPH1,HOXA9,SATB2,PEG10,LPIN1,ZHX2,VEGFD,DNAJA3,IRS2,HEY2,EYA2,WNT5B,MATK,RIMS3,NDRG1,CHN1,RRBP1,THY1,RPA1,MMP2,S1PR3,DOCK1,SRGAP3,CDH2,NR1D1,BSG,IL10RA,GLUL,MAP2K3,LRP8,MAPK7,SFRP1,CYR61,ITGA7,ADM,MME,ADAM17,RALA,TCEA1,NID2,TNFSF10,MYH11,VCAN,EFNB2,ID1,TRIB1,MTOR,CCL3L3,SRGAP1,CMTM8,SNX10,SOCS2,PRKCE,ACSL4,STIM1,RASSF5,LPP,COL18A1,SARS,PLAT,IL11RA,MBOAT7,MYCN,CTSK,C5AR1,ANGPT1,TYROBP,P4HTM,F11R,KRT8,TF,WAS,LIMS1,SPRY2,FCER1G,S1PR1,NR5A2,TAZ,ZFP36L2,FZD7,FBN2,C10orf54,ADRBK1,CXCL12,TAF10,DYNLT1,CYP26B1,MBNL3,CRIP1,ITGA11,ASXL2,BRSK1,OSR1,SIAH2,LTBR,PDK4,EIF2AK1,CSF3R,IGFBP6,MIF,AXIN2,SPP1,APLNR,DNASE2,LMO4,LMNA,SNRK,ZNF616,FOXC1,STC1,TRAPPC9,ITGAM,SRPK3,PKD1,RGN,GNL3,ADAMTS7,LEP,NFIX,NLGN1,ERN1,HPS6,PKM,ABL1,CDH23,TNFAIP3,TET1,UBASH3B,SMPD1,IRF3,HIF1A,CDKN2B,TNFRSF12A,SOX17,HMOX1,TMEM119,KCNMA1,KIT,S100A8,RNF144B,HCST,ALPL,PTGER4,PRNP,CYP27A1,CXCR4,AP3D1,SMAD7,SCIN,ZBTB7C,MKNK2,CCDC3,CSF1R,ENO1,LPAR1,EXOC4,EDNRA,ELK1,P2RX7,MMP9,CARM1	559	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease, Skeletal and Muscular Disorders	uterine leiomyoma	uterine leiomyoma	3.07E-07	 	 	 	 	SOCS3,MEGF9,RPE,AHCYL1,PTTG1,MAF,LHCGR,PPP4C,MYC,NR4A3,ALDH1A1,CYBA,SDPR,CXCL14,MTHFD2,ERAL1,PKIA,WNT5B,ADRA1B,PDK4,SLC2A5,ALDH1B1,CALCRL,CAPN6,DPT,HNMT,PLD3,H19,NDRG1,NDUFS7,SLC24A3,MMP2,AP2S1,RPL9,KCNG1,ABCA8,ADRA2A,COL6A3,ALDOA,HSPB7,SFRP1,CRABP2,CYR61,AK2,ESR1,mir-21,FTH1,POLR3F,NOL7,UQCRH,FGF2,PHLDA2,SCARA5,SLC7A1,RAMP2,VCAN,EIF4EBP1,GNG11,JUN,RGS5,MICALL1,CD24,ECM2,PI4KA,ADRB2,DLGAP4,HYAL1,DDX24,CLEC16A,STXBP6,CYP1B1,FOS,NR4A2,LSP1,LYN,XAF1,NR5A2,ADRA1A,MAOA	79	
Cellular Development, Tissue Development	differentiation	differentiation of connective tissue cells	3.11E-07	 	-1.216	 	-2.096	CTGF,BMP4,AXIN1,TGFBR3,MAF,IL6,SLC9A1,ATP2A2,POR,NR4A3,LPIN1,PEG10,EGR2,RARA,SMARCB1,LUM,MGP,VEGFD,ATF4,EBF2,IRS2,WNT5B,SLC2A5,FBL,SFRP4,CMKLR1,RRBP1,THY1,GRK5,JUNB,CREB5,BCAP29,MAP3K12,MN1,PDLIM7,NR1D1,TFRC,MAP2K3,LRP8,SQSTM1,SFRP1,CYR61,NOTCH1,mir-21,NRP1,ADM,APOE,FYN,GADD45B,DDIT3,SLC1A5,FGF2,CEBPD,ADIPOQ,TNFSF10,CTHRC1,ATAT1,GPC4,ATP6AP1,VCAN,MAFG,EFNB2,ID1,MTOR,JUN,CCL2,CCL3L3,CST3,SNX10,OSBPL11,LY6E,PRKCE,HEY1,CCR1,CD276,C5AR1,MECOM,TYROBP,ZNF521,TOB1,TRIB3,SLIT2,ID3,GLG1,GRN,FOS,MYOC,ZFPM2,NR4A2,LMO3,TF,WAS,FCER1G,SOX9,BMPER,PTGS2,PIN1,BMP6,ID4,FBN2,SOCS3,RARRES2,NOC3L,PARP2,TBX15,ZFPM1,GPC3,MYC,TGFBR2,ADGRF5,ITGA11,ASXL2,OSR1,GSK3B,CAST,PDK4,CXCL8,PTPRE,AXIN2,SPP1,ATF3,LMNA,FZD9,PTGDS,KLF4,STC1,H3F3A/H3F3B,PRKCD,MDK,RUNX1,PTGFR,ANGPTL8,ADAMTS7,LEP,SFRP2,FRZB,ATF5,BMP2,ABL1,UBASH3B,HIF1A,CCL3,HMOX1,TMEM119,COL6A1,SH3PXD2B,EDN1,TIMP1,HSPE1,SMO,S100A8,HCST,IARS,ALPL,PTGER4,ADRB2,AGT,SRC,NLRP3,AP1S2,SMAD6,SMAD7,PLAUR,ZBTB7C,CCDC3,BSCL2,CSF1R,NFE2L1,BTK,FAF1,EBF1,CAPNS1,RRAS2,LPAR1,CAT,EDNRA,NUCB2,CARM1,MMP9	179	
Cardiovascular Disease	peripheral arterial disease	intermediate disease stage peripheral arterial disease	3.32E-07	 	 	 	 	RUNX1,APOE,DNAJB4,SGK1,CXCL12,PPP1CB,VWA5A,CD163,GLRX,SLC2A3,CAAP1,SUCLA2,HLA-DRB1,EGR2,THBS1,AMPH,PLEKHO2,LOC102724428/SIK1,DAB2,STK24,SEMA3B,SLCO2B1,PTGER4,FCGR3A/FCGR3B,GULP1,CCR1,SPP1,UCP2,C5AR1,CXCR4,PLAUR,VSIG4,CAPG,KLF4,NGRN,RPL9,RUFY1,PLA2G4A,CTSA,NR4A2,LPAR1,CYTIP,BTG2,CTSB,LYN,TPP1,EBNA1BP2,PLTP,CCL18,MAP4K4,KTN1	51	
Tissue Development	growth	growth of epithelial tissue	3.44E-07	 	0.947	 	-0.388	BMP4,KCNJ2,TGFBR3,HRAS,CDKN2C,COL8A1,MST1,NCSTN,SERPINA3,POMC,IL6,ODC1,NR4A3,ITGA3,CCND3,CYBA,RARA,SMARCB1,TSC2,CAV1,MGP,VEGFD,HIPK2,HEYL,CDKN1C,NAB1,MTSS1,C1GALT1C1,THY1,HBEGF,JUNB,CDH2,IFT122,CCND2,CTSB,SPINT2,GLUL,ITGA1,SFRP1,PDGFD,NOTCH1,ANG,mir-21,NRP1,ADM,SPTBN1,APOE,FYN,NME1,GBP1,LEPR,FGF2,SEMA6A,GDF15,CDK4,ADIPOQ,TNFSF10,TGM2,EFNB2,ID1,KLF9,MTOR,JUN,CCL2,TNMD,PRKCE,DAB2,COL18A1,HEY1,C5AR1,PTPRK,ANGPT1,ZNF580,EGR1,TOB1,AXL,GRN,FOS,PLA2G4A,F11R,S100A9,PPP1R16B,LIMS1,ATP6V0A2,PROCR,SOX9,BMPER,PTGS2,PIN1,BMP6,FZD7,SOCS3,CD36,ITGB1BP1,CD4,RGCC,CXCL12,SDC4,GPC3,METAP2,MYC,TGFBR2,IKBKG,OSR1,CXCL14,SLC7A5,PDCD6,GSK3B,GPC1,LTBR,RET,KLF2,TEK,PFKFB3,CXCL8,SPP1,FST,MYDGF,ADAMTS1,STK39,EGR3,VEGFC,LMNA,THRA,MYOF,KLF4,INHBB,ATPIF1,CCNG2,ERCC1,PKD1,PRKCD,ALDH1A2,HIF1AN,RGN,FZD5,MDK,ESR1,MAP2K5,VHL,RUNX1,SULF1,IGFBP4,LEP,SFRP2,ERN1,BMP2,PKM,HIF1A,CDKN2B,TNFRSF12A,HMOX1,NFKBIA,ANGPTL4,EDN1,RGS5,TIMP1,THBS1,SAA1,SMO,KIT,S100A8,ERBB2,RNF144B,MAPKAPK2,SULF2,ASIP,AGT,SLC20A1,THBS4,CXCR4,HYAL1,G6PD,SMAD7,PLAUR,CSF1R,EDF1,HRSP12,RCAN1,VAV3,EDNRA,SPARC,KDR,RCAN2,P2RX7,MMP9	186	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of fatty acid	3.50E-07	 	-0.109	 	-0.725	PLIN1,APOB,PFKFB1,CD36,LHCGR,CXCL12,LIPE,MYC,TGFBR2,LPIN1,ADGRF5,BCAT2,SPTLC2,PLA2G5,CAV1,IRS2,HADHA,ADRA1B,PDK4,PTGIS,CXCL8,CIDEC,PTGDS,ECI1,BCL2L1,DUSP1,SLC27A1,ACACA,ITGA1,PLTP,AKR1B1,CCDC80,APOE,SFTPD,SCAP,LEP,LEPR,PPP1R3C,GNA11,ADIPOQ,ELOVL3,NGF,IDH1,HMOX1,HINT1,CES1,ANGPTL4,EDN1,PDE3B,PLIN2,ACSL4,ADORA1,HCAR2,PTGER4,ADRB2,PRNP,AGT,MBOAT7,FAAH,SLC25A13,ABHD5,FMO3,UCP2,CYP27A1,GNAI1,DGAT2,SLCO2A1,BSCL2,TK2,ACLY,CYP1B1,PLA2G2A,FOS,GPAM,PLA2G4A,CIDEA,LOC102724788/PRODH,LDLR,CBS/CBSL,APOC1,MAP3K8,TAZ,PTGS2,MMP9	84	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of cells	3.61E-07	Increased	2.213	bias	-0.258	CH25H,PFN1,CD36,CD4,TYRO3,ELANE,RGCC,C1QA,IL6,BIN1,SPI1,CLIP1,MYC,PADI4,ETS2,ABR,CYBA,PLA2G5,LUM,CAV1,CLCN3,KLF2,GULP1,MARCO,CSF3R,EIF2AK1,PTX3,MIF,ATG7,CD302,CHN1,CAPG,HSPA8,DOCK1,COLEC12,ASGR1,ITGAM,PIP5K1C,RAP1GAP,PRKCD,CD14,FZD5,SLC11A1,CNN2,FYN,SFTPD,RALA,LEP,ABL1,ADIPOQ,ABCF1,SMPD1,GLRX,TGM2,HMOX1,THBS1,ANXA5,SAA1,MEX3B,TUB,PRKCE,STIM1,ADORA1,MAPKAPK2,FCGR3A/FCGR3B,PTGER4,SRC,UCP2,CSK,PLAUR,AXL,BTK,PLA2G4A,RRAS2,SWAP70,S100A9,WAS,CAT,ANXA3,PELI1,LYN,FCER1G,P2RX7	83	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of phospholipid	3.67E-07	 	-0.088	 	-0.924	CD36,ABCA3,VAC14,HRAS,ABCG1,IL6,CEL,GLB1,RARA,SPTLC2,ACP6,CAV1,TEK,CERS6,CXCL8,SPP1,STOML2,FIG4,SLC3A2,PIP5K1C,PRKCD,RGN,CD14,ACACA,PLTP,ABHD12,APOE,SCAP,SFTPD,LEP,PTPMT1,TNFSF10,SMPD1,INPPL1,HIF1A,NGF,MTOR,HINT1,ANXA5,SAA1,ENPP2,LIPG,PI4KA,PI4KB,MBOAT7,ABHD5,FMO3,CYP27A1,DGAT2,BRMS1,BSCL2,THRSP,PLA2G2A,GPAM,PLA2G4A,DGKQ,LDLR,CBS/CBSL,FCER1G,PTGS2,PNPLA6	61	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	urinary tract tumor	urinary tract tumor	3.70E-07	 	-0.477	 	-0.192	CBX7,SLC6A9,PCLO,VAC14,TPRG1,IL6,POLRMT,SLC39A8,POR,UPK3BL,CCND3,AJUBA,GLB1,TSC2,SMARCB1,DEFB132,WASH3P,PTGIS,SLC2A5,RANBP3,LARP4,PTPN3,PDLIM7,CDH5,mir-21,KIAA1217,EPHX1,CD163L1,PSMD7,GNA11,MFSD5,MECOM,PDZD2,AFF3,HNRNPH1,GCNA,SOX9,ARSD,DIRAS1,GPC3,INTS1,LHFPL2,TUBA1C,BIRC3,TEK,MARCO,CXCL8,H19,STK39,ERCC2,GUF1,FAAP20,BCL2L1,AEBP2,RPL8,BAP1,C17orf97,VHL,SUN1,RPH3AL,SH3PXD2B,ERBB2,NSFL1C,G6PD,PLAUR,PYGB,POLR3B,RRAS2,TSC22D1,CXCL2,PRUNE2,DDX11,MSRB2,PCDH17,MST1,ZNF605,PRG4,KIF21A,PIK3C2B,BIRC7,ZC3HC1,CENPB,THBD,NINJ1,FAHD2B,CCDC136,SH3GL1,FAM86B1,CCZ1/CCZ1B,EPB42,CCT3,ALAS2,NOTCH1,TMEM158,SERAC1,BTG3,FKBP1A,TBL3,ATP6AP1,CADM2,JUN,CD24,COL22A1,AHNAK2,NPRL2,GJB2,CD209,PLXNA1,CD276,SLIT2,AXL,EMC1,TRMT12,GABRE,LMO3,SBF1,TMEM63B,PTGS2,ATAD3A,ZFYVE19,SPNS1,CLEC3B,SLC35F1,GUSB,ZNF91,METAP2,GSPT1,ETS2,COMT,ACP6,MCTP1,RET,STX11,MFSD3,FERMT3,ACSL3,TRIOBP,EGR3,ALAD,NDUFAF2,GPAA1,INHBB,TPSAB1/TPSB2,FLCN,COL6A3,RAP1GAP,PRKCD,SCRIB,LMAN2L,XPNPEP1,CDK5RAP2,NFKBIA,THBS1,ASAP3,CHEK2,ZNF493,EMILIN1,LXN,EPAS1,TPST2,PHLDA3,LRRK2,ACAT1,GLMP,GBE1,KDR,XK,SLC47A1,DHRS7B,SYTL2,PLEKHM2,CLIP1,ODC1,NPL,KEAP1,ARHGAP39,CAV1,TSHZ2,PIGT,TM6SF1,STK36,PPP1R1B,CARMIL1,IFNAR2,TFPI2,SHROOM4,MN1,NRDE2,BTG2,PPP1R15A,GCC1,ZDHHC1,NME1,OSGIN1,FGF2,CUBN,IGSF1,CDK4,CTDSPL,LAMP3,MRPL22,CCL2,POFUT2,ARFGAP1,PLIN2,IL34,ADORA1,RAD21,ALDH5A1,CYP51A1,S100A1,CCR1,TJP1,DGAT2,ARHGEF5,FOS,FLNC,ATP1A2,MBD3,TAF1C,MAP3K8,RBP5,C11orf68,BMP6,CPXM1,HAGH,QPCT,SESN2,ATP2B1,ABCA3,MBP,KLF6,HSPA1A/HSPA1B,MYC,TGFBR2,RHOB,GPR4,MOCOS,GIMAP5,KIF25,LRBA,ATF3,RILPL1,MAST4,UNC13B,SRPRB,LAMA2,VEGFC,DCHS1,FOSB,SDCBP,IGFBP3,ESR1,S100P,RUNX1,PTGFR,SLC1A4,HNRNPK,GSTT1,IRAK1,POLR1C,RPL14,HLA-DRB1,AHNAK,TIMP1,SAA1,LOC102724428/SIK1,LRPPRC,MCRS1,NUSAP1,TUBG1,NQO1,GNAI1,ATIC,CXCL16,HEPACAM,SMG7,CDC34,NNAT,SLC29A4,MIB2,WDR45,CDKN2C,HRAS,LPIN1,ANK2,IRS2,CALCRL,NANOS1,TUBB2A,MMP2,RAE1,SRGAP3,AQP9,TIMP4,CCND2,BSG,NPRL3,IL10RA,CDRT1,TRO,ADM2,RPL6,MAP2K3,RSU1,SFRP1,MAPK7,AIDA,CYR61,PHLPP1,SPTBN1,MME,ADM,HIST1H1C,ADAM17,RALA,XPOT,TNFSF10,IDH1,UCHL1,TRIB1,MTOR,ANXA5,PRKCE,PTPRT,MBOAT7,PLAT,GSTM1,MYCN,TWNK,MGMT,DEFB1,COL5A3,MRPL51,KRT8,MCM2,TF,PPP1R16B,NOP2,CHFR,BNIP3L,GABARAP,ZFP36L2,FBN2,RGS1,NAGK,CXCL12,XPO5,IL17RC,TPM1,ARG2,TUBB,ASXL2,SIAH2,PUF60,FAM65B,PDK4,AXIN2,SPP1,NUP155,PANK1,PPP2R1A,PKD1,SMOX,RRP7A,RGN,TMOD1,MAP2K5,RNPEP,ADAMTS7,PKM,CDH23,ABL1,HIF1A,ACOT7,FAM110B,EPHB6,HMOX1,PCK2,FLNA,KCNMA1,CSPG4,FUBP3,KIT,CUL9,TMEM132B,ASIP,FAAH,SNAPC4,FRMD1,AP3D1,SMAD7,ZBTB7C,NFKBIZ,CSF1R,LPAR1,TSPAN1,MMP9	398	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	colorectal neoplasia	colorectal neoplasia	3.93E-07	 	1.427	 	1.867	PCLO,SLC39A8,AJUBA,PPRC1,SMARCB1,WASH3P,ETS1,SRPRA,SLX4,DVL2,CDH5,ALCAM,TRIAP1,RAB40C,BRE,mir-21,LTBP2,GBP1,KIAA1211L,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,THNSL2,PDZD2,MTHFD1L,AFF3,KIF7,SWAP70,CBS/CBSL,ATP6V1F,NDST2,CYP4F11,AKR1C3,HAVCR2,TRPM8,TMEM169,INTS1,CBX5,TSPAN17,CARD8,NDUFA10,NSMAF,TEK,ADAMTS1,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,PSME4,C17orf97,RAB11FIP5,MRPL15,RPH3AL,FLRT1,EMX2,HDGF,THYN1,COL6A1,F8,EPN1,NLRP3,TCEA3,PLAUR,FRMD4A,CLEC16A,ACADVL,TXNDC12,FECH,TSC22D1,AP3M2,ING1,MAP4K4,MED24,CTGF,SNTA1,CA12,HOMER3,RNF38,ZNF395,PRG4,SPAG8,PNKD,MCL1,PIK3C2B,BIRC7,ATG7,SV2B,CENPB,MT1X,PLEC,FAHD2A,CNOT10,MALSU1,APEH,FAHD2B,CCDC136,MAP3K12,EEF2KMT,ISLR,RSAD1,AKR1C4,NOTCH1,COL3A1,NRP1,SORL1,CPSF2,ZFP36,LEPR,SIN3B,EFHD1,FKBP1A,RUVBL1,CST3,ZNF608,HGS,AHNAK2,LIMCH1,CCDC68,CD209,ANKRD9,STAMBPL1,COL12A1,TRIM28,EGR1,DDX24,NTM,ACLY,COPS3,SBF1,CELF2,PQLC2,PTGS2,FBXW9,CHD7,ARID4A,COBLL1,CLEC3B,LHCGR,ZNF91,PLCE1,MCTP1,FAM193A,FST,EGR3,IRX6,SLC4A7,ATP10A,SLC39A3,SORD,LRRC41,COL6A3,DUS1L,FRYL,TOMM34,SCRIB,YIF1A,CDK5RAP2,HIGD1A,ZNF174,MAN1B1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,ASAP3,SULF2,ZNF493,ATP2C1,LRRK2,TANC2,PLSCR4,EMP1,PLEKHH1,PAG1,PLP2,MT1F,SLIT3,NIPA2,HCAR3,SYTL2,MAP6,CACNA1H,ANKRD20A4 (includes others),ATP2A2,MT1E,ODC1,CAAP1,GATAD2A,NUP93,EFHB,ARHGAP39,PLEKHO2,WDR47,ALDH3A1,TSHZ2,MRPL24,NUP43,PDIA5,ALDH1B1,DPT,SOGA1,MTSS1,MFAP5,LAMC3,HAX1,WDR81,NRBP1,SLC7A10,PYGO2,MN1,TMEM41B,MRPL17,ARHGEF6,PHF23,TFRC,CD86,KCNIP4,SQSTM1,BYSL,PTPRA,ZDHHC4,NOL7,SLC4A2,PLXNA3,CUBN,IGSF1,SCUBE2,GDF15,HSD17B11,CDK4,CEBPD,DUSP22,CRAT,TECR,KLHDC9,GADD45GIP1,DUSP5,POFUT2,CCL2,DAB2,ALG8,ADORA1,RAD21,C11orf54,LIG3,SLC38A7,HELZ,GLRX2,DGAT2,STON1,OLFML3,C1orf122,FAM178B,SDF2L1,NTRK3,ARHGDIA,BMPER,TP53BP1,AFG3L2,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,ISM1,NOC3L,ABCA3,RTN1,NTMT1,ACO2,TYMP,CES2,GPNMB,MYC,TGFBR2,TPRN,ZNF598,GYPE,METTL5,STAB1,SMPDL3A,PFKFB3,ATF3,RILPL1,VEGFC,DCHS1,CDC42BPB,MATN2,SORCS2,C2,PMEPA1,RBP4,MAST2,ERAP2,SPIRE2,SRPX,SCARA5,DENND4B,SLC38A1,NEURL4,GSTT1,SLC2A3,ETV6,HLA-DRB1,TRIM6,AHNAK,TIMP1,MCAM,MEX3B,LOC102724428/SIK1,CIZ1,IARS,SLC20A1,VCAM1,PARVA,RNLS,SLC12A2,ST3GAL6,CANX,N4BP1,BSCL2,NFE2L1,SERPINE2,SH3PXD2A,SLK,XYLT2,CLGN,LOC102724788/PRODH,PHF19,CAT,ISG20,MIB2,SGK1,TRAP1,CDKN2C,GTF2IRD1,HOXA9,NCOA7,SLC4A3,ABR,ZHX2,VEGFD,RIMS3,MMP2,SCNN1D,RAE1,DOCK1,SRGAP3,PPIH,DHRS9,PIP5K1C,C11orf80,MAP3K20,IL10RA,ALDOA,LRP8,BACE2,AIDA,PDGFD,ITGA7,RERGL,FAXDC2,VCAN,TMEM94,MTOR,TADA3,DHPS,SRGAP1,ALDH1A3,PRKCE,ACSL4,COL18A1,PLOD3,PLAT,DNAH6,CYP11A1,SOX7,GSTM1,RRP12,PCDH9,NR2C2AP,STXBP6,POLD1,POMGNT1,TRMT1,P4HTM,CLDN5,RBM6,ZFP36L2,VPS52,MAPRE3,FZD7,MVD,C10orf54,PTPN23,VPS28,COBL,SDAD1,OSR1,TMEM150A,KPNA2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,ACTA1,PTX3,CSF3R,APLNR,SPP1,SGCG,ZNF408,MACROD1,MARS,PANK1,TRAPPC9,RRP7A,THSD7B,AKR1B1,COL7A1,AOC3,DRAP1,ADAMTS7,B3GALT6,LEP,PRDX5,HPS6,FLRT2,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,FUBP3,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,DLGAP4,CPED1,SMAD7,ENO1,DYM,OLFML2B,TANGO2,RDH5,UBA1,ATP6V1B2,MMP9,CARM1,KCNJ2,AXIN1,PPP2R3B,MTG1,IL6,POLRMT,PPP1R14B,EIF3B,CSE1L,AMHR2,AHCY,PTGIS,HEYL,PTOV1,TMEM100,PDLIM7,CTSB,C15orf39,EPHX1,COL4A5,DAPK2,GNA11,ZNF419,GTF3C1,MECOM,KIAA1549L,CDO1,PVR,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,RARRES2,MICALL2,AP1B1,OSCP1,CCT5,KMT5A,CXCL8,STK39,UROS,CBX6,ERCC2,AKR1B10,ADRA2A,SLC7A2,CCDC80,TNS1,VHL,SLC11A1,SULF1,IGFBP4,PLGRKT,DNASE1L3,BMP2,INPPL1,COL6A6,HLA-G,ALDH2,ESPNL,ERBB2,THBS4,SRC,RGS20,COL6A2,ITM2C,COL11A1,PRUNE2,DDX11,TYRO3,PCDH17,GYG2,POMC,PLS3,IRX3,KIF21A,CAPN5,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,ROR1,NLRX1,RNASEH2A,BCAP29,NGRN,LARGE1,AAAS,PDE1B,RTN4,AKAP12,SQLE,FYN,BTG3,ATAT1,NAA35,ABCA5,THBS3,EIF4EBP1,ENAH,JUN,ZNF334,CSF2RA,DCXR,MYO1D,ECM2,FUK,PLXNA1,CEP164,NOL6,PTPRK,MYOM2,WDR55,ARHGAP4,PAICS,NBEA,SLIT2,BRMS1,TMEM42,AXL,PLA2G2A,DCAF13,SLC48A1,ANXA3,MAMSTR,TM4SF1,LRFN4,TFF3,TNFRSF4,FARP1,FAT1,CD36,CD4,MAP1B,NDUFB10,WDR5,SLC25A6,MYOM1,BCL7C,GPC1,RET,HLA-F,EPB41L1,C7orf50,PTPRE,TRIOBP,PACSIN3,ICA1,HSPA9,PCDHA1,MAPK8IP3,KIAA0922,FLCN,C9orf16,PRSS23,RAP1GAP,PRKCD,RARRES3,CLCN7,CRABP2,SMAP1,SH3RF3,KIAA1191,ATF5,SLC4A11,IPO9,ANGPTL4,HSPE1,SMO,CDCA5,NCL,IFRD1,CHEK2,EMILIN1,PAK4,LRRC2,EPAS1,PCOLCE2,VSIG4,SGTA,PPP1R16A,PRMT1,IL18RAP,COLEC11,C2orf88,NAT8L,CYC1,APOC1,ACAT1,EPHB3,GBE1,NUCB2,GPR160,PDE8B,CPZ,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,CTSG,COL8A1,SERPINA3,PLEKHM2,SLC9A1,CLIP1,FADS3,ZNF263,EGR2,IQCC,KEAP1,CEP170B,CAV1,ATF4,STK32A,UNG,TMEM97,PIGT,TM6SF1,SELE,PODN,PPP1R1B,SMG5,ANO6,NPY5R,TFPI2,SHROOM4,ZNF579,HSPA8,EVPL,NRDE2,CTSA,LRRN3,CBLN3,VARS2,FSCN1,MCEE,CCDC178,ITGA1,SAMD4A,FGF2,MMP25,SLC35B2,LAMP3,HS3ST3A1,GRINA,COL16A1,ZMYND19,RANGAP1,PIK3R2,TRIM29,FCGR3A/FCGR3B,G3BP2,NINL,ZNF524,TOB1,SLCO2A1,TRIB3,PRDM11,AGL,HSPA2,GLG1,FOS,PLA2G4A,NRXN2,NR4A2,FLNC,TAF1C,AARS2,NLE1,ABCC3,CSTF3,QPCT,ABCB6,FOXRED1,TRAPPC2L,SESN2,ATP2B1,SLC38A10,PTTG1,MBP,DPP7,POLR3E,KLF6,AP2A2,CLPP,GPR4,FAR2,GCLM,CHTF18,CHMP1A,PDZRN3,KCNJ8,LRBA,DOK2,LAMA2,CAPG,ANO1,OSBPL7,C9orf114,KLF4,SLC3A2,KCNG1,CBX1,ORM1,SOBP,IGFBP3,MEGF8,DOCK6,PCMTD2,RUNX1,TPR,ABCF1,CRYL1,GLRX,GCDH,POLR1C,SHC1,MKL2,ENPP2,LRPPRC,TOX2,MCRS1,LONP1,AGT,PSAT1,SUGP2,SLC22A12,TUBG1,PWWP2B,NQO1,NUP210L,PMP22,PIGB,TACC2,KIF5B,ASTN2,SMG7,IVD,NREP,CADM3,DPYD,C1orf115,APOB,ITSN1,TGFBR3,NCSTN,RAPH1,PCOLCE,NMUR2,GAA,NPTX2,ANK2,EYA2,MATK,CACHD1,CALCRL,PEX6,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CCND2,PTPRB,STIP1,ADAMTS18,GLUL,SFRP1,IFIT2,MYEOV,ADM,MME,HIST1H1C,ADAM17,MSC,PIGO,GRB14,ZNF330,TCEA1,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,TTC1,MYH11,RPP40,IDH1,FANCE,COL5A1,EFNB2,SLC2A6,HLCS,SNX10,CLMN,PSMD14,STIM1,SH3GLB2,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,PI4KA,MYCN,SEMA3G,STK19,IMPDH2,MGMT,DPAGT1,CYP1B1,B4GALT2,PLEKHG6,TF,S100A9,CDK20,PPP1R16B,NOP2,DENND1A,LSP1,MS4A2,NR5A2,CBX4,NEDD9,FBN2,PHLDA1,ADSSL1,CXCL12,TPM1,TUBB,CEL,TNIP1,CRIP1,BRSK1,SLC7A5,C14orf180,PUF60,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,TEX2,ST6GALNAC3,SNRK,PKN1,EFS,PPP2R1A,ITGAM,ERCC1,SMOX,SLC22A5,SNX1,EXTL3,PLEKHH3,EPB41L3,PKM,ABL1,RBBP8,CDH23,MRPL2,TET1,SMPD1,GPR34,MYLK,ITGA10,HIF1A,FBXO3,ACOT7,CDKN2B,FAM110B,PDCD4,COL1A2,SOX17,NFX1,HMOX1,NKD2,AEBP1,CCL13,KCNMA1,POLN,CLOCK,KIT,NEK7,HCST,CUL9,ALPL,PTGER4,PRNP,MIPEP,TRIP6,ZBTB7C,RAPGEF5,COQ2,ZDHHC7,CCDC3,CPA4,ARHGAP28,CYTIP,DIP2C,LPAR1,JCHAIN,RTN3,DSG2	979	
Tissue Morphology	quantity	quantity of cells	4.01E-07	 	0.638	 	-2.787	PCLO,C1QA,IL6,IDUA,CCND3,GLB1,TSC2,SMARCB1,TNFRSF21,ETS1,HEYL,RBM38,CLEC4G,DVL2,NPR3,CTSB,ALCAM,FTH1,GADD45B,EIF4EBP2,DDIT3,ADIPOQ,MCTS1,DIABLO,LLGL1,ATN1,MECOM,ZNF521,CD69,ID3,IGF2R,MYO5A,GPR183,SWAP70,CBS/CBSL,LYN,SOX9,NDST2,LIG1,SOCS3,HAVCR2,DPYSL4,FCER1A,GPC3,CTSD,BIRC3,TEK,CXCL8,NOX4,ADAMTS1,TXNRD1,BCL2L1,FAM26F,NAGLU,SYN1,VHL,SUN1,LITAF,SFTPD,ZP3,BMP2,EMX2,INPPL1,HDGF,HLA-G,ALDH2,EDN1,ERBB2,SRC,PLAUR,SERTAD1,BTK,SPARC,CXCL2,BMP4,CTGF,TYRO3,PCDH17,MST1,POMC,SGPL1,NR4A3,ITGA3,LGMN,IRX3,RARA,MGAT4B,MCL1,CMKLR1,DFNA5,ATG7,ZC3HC1,DKC1,HBEGF,HMGA1,JUNB,THBD,SH3GL1,MAP3K12,EPB42,GDPD5,SAC3D1,NOTCH1,NRP1,CNN2,FYN,MAP7,ZFP36,LEPR,NQO2,SIN3B,SLC1A3,EIF4EBP1,CES1,JUN,TUB,ACVR1C,EGR1,SLIT2,AXL,RELN,BMF,PTGS2,ARID4A,TNFRSF4,CD36,CD4,MAP1B,LHCGR,IKBKG,CAMK2D,PLCE1,ETS2,COMT,PLA2G5,GSK3B,RET,BCKDK,STX11,FERMT3,FST,EGR3,HSPA9,SLC4A7,FZD9,PAWR,AGTRAP,NXNL1,RAP1GAP,PRKCD,RARRES3,IDO1,CLCN7,UVRAG,NGF,PTPRF,HINT1,NFKBIA,DKK3,THBS1,DUSP10,SMO,FNDC5,MAPKAPK2,ADRB2,ZFP42,RHBDD3,EPAS1,ATP2C1,LRRK2,VSIG4,IL20RB,COL1A1,EBF1,PAG1,ACAT1,C6,KDR,CLEC10A,SYTL2,MAP6,SLC35C1,SPI1,IP6K3,EGR2,RAB38,LUM,ST6GALNAC2,CAV1,MTHFD2,DLG4,ATF4,EBF2,HIPK2,SELE,MFAP5,MAD2L2,LAMC3,IFNAR2,HAX1,IFT122,PPP1R15A,ARHGEF6,TFRC,CD86,ITGA1,SQSTM1,DEAF1,APOE,SLC4A2,FGF2,GDF15,ACKR2,CDK4,G6PC3,TGM2,GADD45GIP1,CCL2,GADD45A,SORBS1,IL34,FCER2,HEY1,TSTA3,S100A1,CCR1,CUL7,TOB1,GFRA2,CBR3,GRN,ARHGEF5,FOS,NR4A2,LDLR,NTRK3,FLNC,ARHGDIA,TP53BP1,MAP3K8,PIN1,BMP6,ST3GAL4,MAOA,MT2A,ABCA3,MBP,ITGB1BP1,PTTG1,POLR3E,ABCG1,STARD7,MYC,TGFBR2,ADGRF5,RHOB,MAP2K2,CXCL14,STAB1,PDCD6,NEDD4L,ATF3,PSMB5,DOK2,UNC13B,LAMA2,VEGFC,THRA,KLF4,FOSB,NOL3,ORM1,DUSP1,ALDH1A2,IGFBP3,MDK,ESR1,INO80B,RUNX1,CDC20,MPZL2,CADPS2,CCL3,ETV6,IRAK1,CIAPIN1,SHC1,HLA-DRB1,TIMP1,SAA1,MKL2,AGT,SLC20A1,VCAM1,SLC12A2,NQO1,ST3GAL6,CANX,BSCL2,PSME3,NFE2L1,SERPINE2,RCAN1,CXCL16,CIDEA,CAPNS1,VAV3,CAT,DNM1L,APOB,SGK1,TGFBR3,MAF,HRAS,CDKN2C,HOXA9,MFAP2,NPTX2,DNAJA3,IRS2,EYA2,APEX2,WNT5B,MATK,CALCRL,GUCY1A3,NAT10,MMP2,S1PR3,CCND2,BSG,MAP3K20,IL10RA,MAPK7,ADM,MME,ADAM17,RALA,PSMB10,TNFSF10,MYH11,DCLK1,EFNB2,ID1,TRIB1,MTOR,GBA,CCL3L3,SLC19A1,PRKCE,LIPG,RASSF5,COL18A1,IL11RA,PLAT,MYCN,CTSK,C5AR1,TYROBP,IMPDH2,MGMT,HDC,POMGNT1,YBX2,B4GALT2,COL5A3,KRT8,S100A9,TF,WAS,SPRY2,CNN1,LSP1,FCER1G,S1PR1,BNIP3L,ZFP36L2,NEDD9,SYN2,RGS1,SPHK2,PLA2G15,CXCL12,LIPE,CYP26B1,TNIP1,PRND,NEO1,LTBR,CLCN3,KLF2,RTN4R,ADRA1B,PDK4,EIF2AK1,CSF3R,IGFBP6,MIF,SPP1,DNASE2,MYOF,PKN1,ITGAM,ERCC1,PKD1,AOC3,LEP,NLGN1,ABL1,RBBP8,TNFAIP3,TET1,SLC7A1,SMPD1,HIF1A,CDKN2B,HMOX1,FLNA,CSPG4,KIT,HSD11B2,NSMF,S100A8,HCST,CTDNEP1,ALPL,PRNP,FAAH,CD59,CYP27A1,CXCR4,F13A1,TRIP6,CCDC3,CSF1R,ENO1,ITPA,LPAR1,CYTIP,FASTK,JCHAIN,EDNRA,P2RX7,MMP9,CARM1	445	
Cellular Assembly and Organization, Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development	growth	growth of neurites	4.14E-07	Increased	2.459	 	-0.056	CAMK1,BMP4,SGK1,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,TSC2,CAV1,DLG4,DNAJA3,TXN,TESK1,MATK,RND2,RIMS3,CHN1,PRAG1,GRK5,MMP2,TNK2,NINJ1,DOCK1,DVL2,SRGAP3,CDH2,RTN4,ITGA1,MAPK7,NOTCH1,PTPRA,NRP1,SPTBN1,APOE,ADAM17,PLXNA3,BTG3,FGF2,DCLK1,VTI1B,VCAN,EIF4EBP1,TGM2,EFNB2,MTOR,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,EGR1,GFRA2,SLIT2,RELN,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,MAOA,MT2A,SOCS3,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,BRSK1,GSK3B,NEDD4L,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,NGF,PTPRF,TNFRSF12A,SHC1,NFKBIA,ARHGAP17,STUB1,THBS1,MARCH8,DUSP10,USP47,KIT,ENPP2,NSMF,PRNP,SRC,VCAM1,PAK4,EPN1,RTKN,SLC12A2,LRRK2,ZPR1,SERPINE2,FAIM,KIF2A,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,TNFRSF19,MMP9	134	
Immunological Disease	allergy	allergy	4.45E-07	 	-0.005	 	-0.609	PLIN1,POMC,IL6,SPI1,LGMN,ZNF395,AHCY,MCL1,MAD2L2,FLOT1,JUNB,BRF2,GAPDH,ALDOA,TFRC,MAP2K3,mir-21,MME,FYN,ADAM17,ZFP36,LEPR,GNA11,ADIPOQ,TNFSF10,FKBP1A,RUVBL1,IFI27,TGM2,C1R,MTOR,JUN,GADD45A,CSF2RA,CST3,ANXA5,SOCS2,STIM1,LBP,ADORA1,CYP51A1,P4HA2,FCER2,HDC,DEFB1,SLIT2,PLA2G4A,LY96,NR4A2,S100A9,ANXA3,LYN,FCER1G,FKBP4,MS4A2,MAP3K8,PTGS2,ADRA1A,RGS1,NAGK,TNFRSF4,ADRBK1,HAVCR2,ACO2,FCER1A,TPM1,STARD7,TUBB,HSPA5,PTGES2,DDX41,ADRA1B,CPNE1,PDK4,CXCL8,PFKFB3,HNMT,TRIOBP,CAPG,PTGDS,RAB34,BCL2L1,H3F3A/H3F3B,CORO1B,ADRA2A,DUSP1,CCL18,ESR1,UBE2I,SFTPD,LEP,ABL1,TNFAIP3,SMPD1,ALDH2,HLA-DRB1,CCL13,AHNAK,TIMP1,FLNA,DUSP10,KIT,S100A8,ADRB2,SRC,CXCR4,SMAD7,NFKBIZ,PRMT1,ENO1,ACADVL,CYTIP,VAV3,CAT,PDE8B,MMP9,FCGBP	117	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	infiltration by neutrophils	4.66E-07	 	-0.742	 	-1.438	SOCS3,CTGF,ADRBK1,CD36,UNC5B,CTSG,ELANE,IL6,TGFBR2,RSPO3,PTX3,CXCL8,CMKLR1,SELE,SPP1,THBD,ITGAM,DUSP1,CTSB,CD14,SFRP1,MDK,PLTP,C2,ADM,APOE,ADAM17,NQO2,ADIPOQ,TNFAIP3,CCL3,HMOX1,CD55,NFKBIA,TIMP1,CFB,STIM1,ERBB2,LBP,GJB2,AGT,PLAT,NLRP3,C5AR1,NQO1,HYAL1,LRRK2,SLIT2,VAV3,FCER1G,PROCR,MAP3K8,PTGS2,CXCL2,MMP9	55	
Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of focal adhesions	4.67E-07	 	-0.197	 	-1.613	AKAP12,CTGF,FGF2,ITGB1BP1,GNA11,HRAS,SDC4,SLC9A1,PHLDB2,TGM2,COL16A1,NSF,EDN1,RHOB,NET1,SORBS1,THBS1,RHOD,AJUBA,CAV1,PRKCE,ENPP2,GNG5,COL18A1,TEK,TESK1,ACTN1,AGT,ADRB2,SRC,PAK4,SPP1,PTPRK,CSK,RTKN,GNG2,THY1,MMP2,PTGDS,JUNB,GPM6B,CDC42BPB,MYOC,RAP1GAP,LIMS1,SPRY2,S1PR1,PTGS2,KDR,PTPRA	50	
Developmental Disorder	hypertrophy	Hypertrophy	4.83E-07	 	0.489	 	0.988	KCND2,BMP4,CTGF,PLIN1,SGK1,SNTA1,CACNA1H,HRAS,IL6,ATP2A2,SLC9A1,ODC1,NR4A3,CYBA,GAA,RARA,TSC2,PNKD,CAV1,TXN,HEY2,WNT5B,CASQ2,PTGIS,CMKLR1,NAB1,GUCY1A3,HBEGF,GRK5,IER3,HMGA1,CTSB,MAP2K3,MAPK7,mir-21,ADM,APOE,ADAM17,FHL1,PIGO,FGF2,LEPR,GNA11,GDF15,ADIPOQ,CDK4,FKBP1A,H2AFZ,EIF4EBP1,DUSP5,MTOR,JUN,PRKCE,ADORA1,PLAT,ANGPT1,SLIT2,IGF2R,CYP1B1,GRN,PLA2G4A,LYN,SOX9,PTGS2,ADRA1A,PFN1,PFKFB1,CD36,PTTG1,LHCGR,CXCL12,TPM1,MYC,TGFBR2,GPX3,CTSD,CAMK2D,PLCE1,MYOM1,NUPR1,STAB1,GSK3B,CAST,ACTG2,ELN,NOX4,MIF,FST,ATF3,SGCG,PGAP3,KLF4,LMCD1,STC1,ADRA2A,DUSP1,PRKCD,ESR1,MAP2K5,RBP4,LEP,BMP2,ABL1,TNFAIP3,INPPL1,HIF1A,NGF,HMOX1,SHC1,NFKBIA,EDN1,RGS5,TIMP1,HSD11B2,ADRB2,AGT,SRC,RNLS,EPAS1,P2RX4,PGAP2,SMAD6,SMAD7,EMP1,RCAN1,COL1A1,ADGRG1,PBX3,VAV3,CAT,EDNRA,RCAN2,MMP9	133	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of membrane lipid derivative	4.97E-07	Increased	2.074	bias	-0.528	APOB,HACD1,VAC14,SH3GLB1,POMC,SPI1,POR,SGPL1,IP6K3,LPIN1,GLB1,SPTLC2,ABCC1,CAV1,LSS,CERS6,PIK3C2B,SERINC1,PLAA,SERINC2,LARGE1,PIP5K1C,SLC27A1,PLTP,SQLE,APOE,MAP7,SCAP,PIGO,RALA,FGF2,LEPR,DPM2,ADIPOQ,TNFSF10,HEXA,MTOR,CES1,GBA,CCL2,ALDH5A1,CYP51A1,PI4KA,MBOAT7,CYP11A1,ABHD5,ACLY,PTDSS2,PLA2G2A,GPAM,PLA2G4A,FOS,LDLR,DHCR24,LYN,PTGS2,TAZ,MAOA,CH25H,SOCS3,PIGU,ADRBK1,PLA2G15,PIGQ,ABCG1,CEL,ACP6,PLA2G5,PCYT2,MTMR2,NSMAF,PTX3,CXCL8,PEX7,GM2A,ST6GALNAC3,FIG4,ARSA,ORMDL3,GPAA1,BCL2L1,ABCA8,ACBD6,PRKCD,RARRES3,LEP,PTPMT1,ATF6,INPPL1,SMPD1,NGF,HMOX1,DHCR7,EDN1,SAA1,KIT,ENPP2,PI4KB,ADRB2,AGT,CYP27A1,G6PD,CSF1R,ENO1,PIGB,CAT,FECH,GAPVD1,KDR,PNPLA6,P2RX7	111	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	morphology	morphology of right ventricle	5.06E-07	 	 	 	 	HEYL,ADAM17,CXCR4,HBEGF,FKBP1A,SLCO2A1,RAMP2,ATP2A2,IGF2R,DOCK1,HMOX1,PLA2G4A,TIMP4,ZFPM2,PLCE1,EDN1,NTRK3,GAA,CAV1,MAPK7,HEY2,GNG5,HEY1	23	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	leiomyomatosis	leiomyomatosis	5.20E-07	 	 	 	 	SOCS3,MEGF9,RPE,AHCYL1,PTTG1,MAF,LHCGR,PPP4C,MYC,NR4A3,ALDH1A1,CYBA,SDPR,CXCL14,MTHFD2,ERAL1,PKIA,WNT5B,ADRA1B,PDK4,SLC2A5,ALDH1B1,CALCRL,CAPN6,DPT,HNMT,PLD3,H19,NDRG1,NDUFS7,SLC24A3,MMP2,AP2S1,RPL9,KCNG1,ABCA8,ADRA2A,COL6A3,DUSP1,ALDOA,HSPB7,SFRP1,CRABP2,CYR61,AK2,ESR1,mir-21,FTH1,POLR3F,NOL7,UQCRH,FGF2,PHLDA2,SCARA5,SLC7A1,RAMP2,VCAN,EIF4EBP1,SHC1,GNG11,JUN,RGS5,KIT,MICALL1,CD24,ECM2,PI4KA,PTGER4,ADRB2,DLGAP4,HYAL1,DDX24,CLEC16A,CSF1R,STXBP6,CYP1B1,FOS,NR4A2,LSP1,LYN,XAF1,NR5A2,ADRA1A,MAOA	84	
Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of filopodia	5.28E-07	 	1.045	bias	-1.590	CTGF,MAP1B,HRAS,SDC4,PLEKHG4,MYC,ITGA3,CRIP1,NEO1,VEGFD,RET,MYO10,TTYH1,CXCL8,ARHGEF4,MTSS1,CHN1,TNK2,MAPK8IP3,SRGAP3,CDC42BPB,FSCN1,CYR61,AKAP12,FYN,RALA,NLGN1,FGF2,GDF15,NGF,ENAH,CCL2,SRGAP1,RHOU,ERBB2,MAPKAPK2,PI4KB,AGT,PRNP,SRC,PKP1,PAK4,PVR,RELN,ARHGEF5,CAPNS1,WAS,VAV3,SPARC,GAP43,KDR,BMP6,TM4SF1	53	
Cell Death and Survival	cell death	cell death of lung cancer cell lines	5.38E-07	 	-1.252	 	-1.281	PFKFB1,AXIN1,RRM2B,ACO2,KLF6,TRAP1,HRAS,CDKN2C,SERPINA3,IL6,HSPA5,AP2A2,MYC,G0S2,RHOB,ABCC1,KEAP1,GSK3B,HIPK2,BIRC3,MCL1,HK1,CERS6,IGFBP6,CDKN1C,ATG7,SPP1,TNFRSF10B,PAWR,HMGA1,TNK2,RASD1,TXNRD1,BCL2L1,TRIM39,DUSP1,PRKCD,IGFBP3,BAP1,TRIAP1,PIDD1,NOTCH1,mir-21,PMEPA1,ADAM17,GADD45B,DDIT3,OSGIN1,FGF2,PKM,TNFSF10,HIF1A,DIABLO,TGM2,MTOR,NFKBIA,JUN,GADD45A,PRKCE,STIM1,ERBB2,SEMA3B,HCST,PTPRT,CHEK2,SRC,RTKN,NQO1,AXL,ID3,LOC102724788/PRODH,NR4A2,PTGS2	73	
Reproductive System Development and Function	fertility	fertility	5.44E-07	Increased	3.511	bias	-0.910	BMP4,APOB,TYRO3,SLC35C1,IL6,HOXA9,APRT,LUM,CAV1,ATF4,IRS2,AMHR2,ZC3HC1,UBE2Q1,SLX4,CENPB,FANCG,SURF1,S1PR3,GAMT,NPR3,PLTP,ADM,AKAP12,FYN,HIST1H1C,LEPR,SRD5A1,GNA11,CDK4,ATAT1,G6PC3,KLF9,CHDH,CST3,PRKCE,ACSL4,ASPH,ATN1,IL11RA,PLAT,AXL,PTDSS2,IGF2R,PLA2G4A,KRT8,FKBP4,FCER1G,ARHGDIA,PIN1,PTGS2,ARID4A,PTTG1,MAP1B,PARP2,LHCGR,LIPE,MYC,PRND,CHTF18,CLCN3,ADRA1B,PTX3,ADAMTS1,STK39,TALDO1,MAPK8IP2,THRA,GNAZ,ERCC2,INHBB,STC1,ERCC1,H3F3A/H3F3B,PSME4,H1F0,ESR1,TMOD1,TNS1,SULF1,LEP,SCARA5,NLGN1,ZP3,RAMP2,FLNA,THBS1,TIMP1,STUB1,CFB,KIT,HCST,SULF2,AGT,PRNP,SRC,EPN1,TPST2,SLC12A2,F13A1,CSF1R,RCAN1,CLGN,CPEB1,MMP9	105	
Cell Signaling, Small Molecule Biochemistry	synthesis	synthesis of nitric oxide	5.56E-07	Decreased	-2.513	 	-4.028	SOCS3,PFN1,ADRBK1,ASS1,KLF6,SNTA1,CTSG,MST1,ARG2,IL6,HSPA4,NOSIP,STC2,CYBA,ABCC1,CAV1,GSK3B,PTGIS,PTX3,NOX4,MIF,SPP1,DOK2,HBEGF,JUNB,KLF4,TXNRD1,S1PR3,DUSP1,PRKCD,SLC7A2,IGFBP3,RGN,CD14,ESR1,TXNRD2,NOTCH1,mir-21,RBP4,ADM,APOE,DDAH2,SFTPD,LEP,BMP2,ABL1,HYOU1,ADIPOQ,TNFSF10,SLC7A1,TNFAIP3,SMPD1,NGF,HLA-G,HMOX1,SHC1,MTOR,HLA-DRB1,NFKBIA,JUN,EDN1,PRKCE,ADORA1,ADRB2,AGT,FCER2,S100A1,SRC,UCP2,ANGPT1,P2RX4,HDC,NQO1,G6PD,GNAI1,CYP1B1,IMMT,S100A9,CAT,S1PR1,PTGS2,PIN1	82	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of antigen presenting cells	5.59E-07	 	-1.596	 	-2.915	CNN2,APOE,APOB,LEP,LAMTOR2,PLGRKT,CD36,ADIPOQ,CXCL12,IRF3,CCL3,GPC3,NFKBIA,RHOB,CCL2,THBS1,HCAR2,AGT,FCER2,CCR1,ETS1,CXCL8,VCAM1,CMKLR1,C5AR1,UCP2,SPP1,COCH,MMP28,CSF1R,ITGAM,LSP1,LYN,S1PR1,IDO1,MAP3K8,MDK,CYR61,KDR,NOTCH1,MMP9	41	
Cardiovascular System Development and Function, Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of vascular smooth muscle cells	5.67E-07	 	-0.645	 	-1.208	SOCS3,BMP4,ADRBK1,CXCL12,IL6,SLC9A1,MYC,NR4A3,GSK3B,TXN,CXCL8,MIF,CALCRL,NOX4,CDKN1C,TNFRSF10B,HBEGF,PTGDS,KLF4,AGTRAP,NCF2,AKR1B1,NOTCH1,mir-21,ADM,IGFBP4,APOE,FHL1,LEP,FGF2,NQO2,BMP2,GNA11,ADIPOQ,CDK4,CEBPD,TNFSF10,HIF1A,PTPRF,TRIB1,HMOX1,EFNB2,CCL2,EDN1,AGT,NQO1,PLAUR,ID3,CYP1B1,MMP9	50	
Metabolic Disease	abnormal activity	abnormal activity of enzyme	6.57E-07	 	 	 	 	APOE,LOX,IGFBP4,NQO2,PPP1R3C,LIPE,TYMP,GPC3,ALDH2,GBA,CSPG4,CST3,GDE1,SLC16A2,TMBIM1,POMGNT2,TNFRSF21,GLRX2,UPP1,SURF1,NQO1,H6PD,THRA,POMGNT1,PANK1,MAP3K12,ACADVL,SLC25A19,ADCY1,IGFBP3,RGN,ADIPOR2	32	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of myeloid cells	6.58E-07	 	-1.333	 	-3.266	RARRES2,CAMK1,CD36,HSPA1A/HSPA1B,ELANE,CTSG,IL6,CAV1,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SELE,SPP1,ATG7,COCH,FLOT1,MMP2,ORMDL3,TPSAB1/TPSB2,CARD9,ITGAM,PIP5K1C,RTN4,CD14,MAP2K3,MAPK7,SFRP1,MDK,AOC3,APOE,ADAM17,LEP,GDF15,IRF3,CCL3,GLRX,LYZ,EDN1,CCL2,CCL3L3,THBS1,S100A8,FCGR3A/FCGR3B,AGT,FCER2,CCR1,VCAM1,C5AR1,NLRP3,MMP28,CD69,ST3GAL6,LRRK2,SLIT2,CSF1R,CYP1B1,RCAN1,LY96,SWAP70,VAV3,CAT,LSP1,LYN,S1PR1,MAP3K8,CXCL2,ST3GAL4,MMP9	70	
Cell Signaling	protein kinase cascade	protein kinase cascade	6.65E-07	Increased	2.299	bias	-0.047	MIB2,BMP4,CTGF,AXIN1,FAM58A,HRAS,MST1,TLE1,IL6,AJUBA,CAV1,DNAJA3,HIPK2,SFRP4,TMEM9B,NLRX1,IFNAR2,MAP3K12,CARD9,CDH2,MAP3K20,MAP2K3,SQSTM1,MAPK7,AIDA,SAC3D1,TSPAN6,HACD3,PHLPP1,FYN,GADD45B,FGF2,LEPR,ADIPOQ,DUSP22,FKBP1A,SLC35B2,TGM2,ID1,TRIB1,CCL2,GADD45A,SOCS2,CD24,PRKCE,CSNK2B,ADORA1,HGS,ANGPT1,MECOM,MYOC,PELI1,NENF,ADRA1A,SOCS3,PIGU,TFG,LAMTOR2,CD36,MYC,IKBKG,TNIP1,MAP2K2,CARD8,LTBR,RET,BIRC3,TRIM5,ADRA1B,CPNE1,SHARPIN,MYDGF,GPS2,DOK2,MAPK8IP2,MAPK8IP3,PKD1,GPS1,PRKCD,IGFBP3,ESR1,SLC11A1,MAP2K5,UBE2I,DOK5,PEBP1,IGFBP4,LITAF,LEP,BMP2,VAPA,C1QTNF1,ABL1,TNFAIP3,IRF3,CCL3,IRAK1,HMOX1,SHC1,FLNA,DUSP10,KIT,ERBB2,MAPKAPK2,STK40,PTGER4,ADRB2,AGT,RHBDD3,SLC20A1,ATP2C1,LRRK2,RBCK1,BTK,LPAR1,KDR,TNFRSF19,MAP4K4,P2RX7	119	
Cell Cycle	interphase	interphase	6.82E-07	Increased	2.620	 	1.447	CAMK1,BMP4,SGK1,RRM2B,HRAS,CDKN2C,POMC,IL6,SPI1,MIA,BOP1,CCND3,CSE1L,SMARCB1,CAV1,NABP2,KAT2A,ETS1,BIRC7,CDKN1C,NDRG1,SLX4,MAD2L2,HBEGF,RPA1,PTOV1,JUNB,HMGA1,IER3,CCND2,BTG2,MAP3K20,TFRC,MAP2K3,MAPK7,CYR61,BRE,NOTCH1,PTPRA,mir-21,AKAP12,APOE,RALA,GADD45B,DDIT3,FGF2,OSGIN1,PAM16,GDF15,CEBPD,CDK4,ADIPOQ,FKBP1A,DTD1,MEOX2,DDX3X,IDH1,EIF4EBP1,SYNM,ID1,MTOR,RABL6,JUN,GADD45A,RHOU,PRKCE,DAB2,CSNK2B,FCER2,MYCN,VPS18,ANGPT1,EGR1,MGMT,AXL,ID3,CYP1B1,FOS,TF,SPRY2,PEA15,NR5A2,SOX9,MAP3K8,BABAM1,TP53BP1,PTGS2,PIN1,ID4,ADRA1A,PRPF19,PTTG1,KLF6,SPHK2,RGCC,CXCL12,TAF10,AP2A2,MTCH2,MYC,TGFBR2,CEL,GSPT1,CAMK2D,BRSK1,PDCD6,GPC1,EPB41L1,NOX4,SPP1,ATF3,H19,GPS2,BTG1,LMNA,KLF4,FAAP20,BCL2L1,CCNG2,CBX1,ERCC1,TRIM39,PKD1,DUSP1,PRKCD,HIF1AN,IGFBP3,BAP1,GNL3,ESR1,VHL,PMEPA1,SUN1,RUNX1,SULF1,LEP,CDC20,ATF5,NELFB,BMP2,ABL1,RBBP8,TET1,NGF,CCL3,CDKN2B,ETV6,HLA-G,HMOX1,SHC1,NFKBIA,NET1,TIMP1,FLNA,KIT,CDCA5,ERBB2,CIZ1,MAPKAPK2,CHEK2,PRNP,AGT,SRC,TAF6,SMAD7,HYAL1,PLAUR,MT1A,CSF1R,TNFRSF14,RBCK1,BTK,NEK11,CAPNS1,CAT,ING1,ELK1,KDR,MMP9	179	
Cell Death and Survival	cell death	cell death of blood cells	6.92E-07	 	1.267	 	0.875	APOB,BMP4,RAN,ELANE,HRAS,SH3GLB1,SERPINA3,C1QA,IL6,SPI1,HOXA9,NR4A3,RARA,ABCC1,CAV1,DNAJA3,IRS2,HIPK2,EYA2,MCL1,ETS1,TNFRSF21,DDIT4,STOML2,IER3,HAX1,HLA-DRB4,CCND2,NCF2,CTSB,GAPDH,CD86,MAP2K3,MAPK7,NOTCH1,FTH1,APOE,HIST1H1C,FYN,NME1,ADAM17,GADD45B,DDIT3,DAPK2,LEPR,FGF2,NQO2,TNFSF10,CASP4,MCTS1,MYH11,EIF4EBP1,DIABLO,TGM2,MTOR,LYZ,JUN,CCL2,CCL3L3,CST3,CSF2RA,PRKCE,PIK3R2,PCBP2,HCAR2,FCGR3A/FCGR3B,PLAT,MECOM,TYROBP,EGR1,CD69,MGMT,TRIM28,ST3GAL3,ID3,FOS,GPAM,PLA2G4A,LDLR,SWAP70,WAS,BMF,LYN,FCER1G,MS4A2,BNIP3L,PIN1,PFN1,TNFRSF4,LAMTOR2,CD4,HAVCR2,POLR3E,FCER1A,CXCL12,ABCG1,TUBB,MYC,TGFBR2,CTSD,IKBKG,PLCE1,ETS2,COMT,GIMAP5,GSK3B,CAST,CCDC86,LTBR,BIRC3,KLF2,HK1,CXCL8,MIF,ATF3,SPP1,DNASE2,ITPR2,EGR3,BTG1,PAWR,THRA,KLF4,PKN1,TPSAB1/TPSB2,BCL2L1,ITGAM,PRKCD,IDO1,CD14,ESR1,MAP2K5,VHL,RUNX1,SFTPD,LEP,ERN1,BMP2,TPR,ANTXR1,ABL1,TNFAIP3,SMPD1,IRF3,HIF1A,NGF,CCL3,ETV6,IRAK1,SOX17,HLA-G,HMOX1,SHC1,NFKBIA,STUB1,TIMP1,THBS1,DKK3,CLOCK,KIT,S100A8,ERBB2,HCST,CUL9,CHEK2,PTGER4,CD59,NLRP3,EPAS1,CXCR4,NQO1,SMAD6,SMAD7,PERP,CSF1R,FAIM,BTK,COL1A1,RCAN1,EBF1,VAV3,CAT,ACAT1,CXCL2,RCAN2,P2RX7,CLEC10A	187	
Cell Death and Survival	apoptosis	apoptosis of myeloid cells	7.04E-07	 	0.795	 	0.706	HAVCR2,CXCL12,FCER1A,SERPINA3,C1QA,ABCG1,IL6,MYC,GSK3B,LTBR,CAST,BIRC3,MCL1,CXCL8,MIF,ATF3,BTG1,TPSAB1/TPSB2,HAX1,BCL2L1,ITGAM,PRKCD,CD14,MAP2K3,NOTCH1,APOE,ADAM17,SFTPD,LEP,DDIT3,LEPR,NQO2,TNFSF10,CASP4,HIF1A,IRF3,NGF,MTOR,NFKBIA,CCL2,PRKCE,S100A8,HCAR2,PLAT,CXCR4,CD69,NQO1,ST3GAL3,BTK,FOS,PLA2G4A,LDLR,CAT,LYN,FCER1G,MS4A2,PIN1,CXCL2,P2RX7	59	
Cellular Function and Maintenance	function	function of phagocytes	7.13E-07	 	-0.447	bias	-1.034	RGS1,CD36,HAVCR2,PLA2G15,TYRO3,UNC5B,ELANE,FCER1A,CXCL12,MST1,IL6,GPNMB,PADI4,IDUA,LGMN,ABCC1,PLA2G5,CAV1,CLCN3,BIRC3,RASGRP2,MARCO,STX11,CXCL8,MIF,CMKLR1,SELE,SPP1,DOK2,CAPG,NLRX1,APBA3,CARD9,ITGAM,PRKCD,IDO1,CD14,SAC3D1,CNN2,APOE,FYN,SFTPD,GADD45B,ZFP36,GDF15,G6PC3,IRAK1,HLA-G,MCOLN1,MTOR,NFKBIA,CCL2,CSPG4,KIT,RASSF5,LBP,PTGER4,PLAT,RHBDD3,FCER2,CCR1,PLXNA1,SIGMAR1,CD209,NLRP3,UCP2,TYROBP,EGR1,PLAUR,TRIB3,AXL,CSF1R,GRN,BTK,FOS,F11R,ARHGEF5,PLA2G4A,LY96,RRAS2,WAS,FASTK,LYN,FCER1G,MS4A2,PTGS2,KDR,P2RX7,MMP9	89	
Organismal Development	formation	formation of vessel	7.14E-07	 	-1.708	bias	-3.139	CTGF,BMP4,TGFBR3,CXCL12,TYMP,C1QA,IL6,GPC3,TGFBR2,VEGFD,LTBR,GSK3B,SELE,ADAMTS1,PCSK5,VEGFC,JUNB,TPSAB1/TPSB2,ORM1,CDH5,ADGRL4,ALDH1A2,MEGF8,AKR1B1,ANG,mir-21,NRP1,SPTBN1,APOE,FGF2,CFC1/CFC1B,ADIPOQ,EFNB2,JUN,CCL2,EDN1,ENPP2,AGT,PTK7,SRC,EPAS1,ANGPT1,CXCR4,SMAD6,PLAUR,BRMS1,KIF7,CAT,SPARC,KDR,MMP9	51	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of blood cells	7.21E-07	 	0.045	 	-2.249	CTSG,ELANE,HRAS,C1QA,SLC35C1,IL6,SPI1,MYADM,ST6GALNAC2,TXN,SELE,THY1,THBD,NINJ1,PIP5K1C,ALCAM,LRP8,ITGA1,PLTP,MAPK7,ITGA7,NRP1,FYN,APOE,ADAM17,GDF15,ADIPOQ,TGM2,CCL3L1,CCL2,CCL3L3,RHOD,ANXA5,LIPG,LBP,RASSF5,ADORA1,FCGR3A/FCGR3B,CCR1,CD209,ANGPT1,CSK,CD69,RGS16,SLIT2,AXL,F11R,SWAP70,S100A9,LSP1,PROCR,FCER1G,LYN,BMPER,PTGS2,NEDD9,RGS1,CD36,CD4,CXCL12,MYC,TGFBR2,TNIP1,RHOB,STAB1,LTBR,FAM65B,MARCO,RASGRP2,FERMT3,PTX3,CSF3R,CXCL8,MIF,SPP1,ITGAM,ORM1,RAP1GAP,CD14,AOC3,SFTPD,ZP3,ABL1,HIF1A,CCL3,GLRX,CD55,NFKBIA,THBS1,SAA1,MCAM,KIT,S100A8,PTGER4,AGT,ADRB2,SRC,CD59,VCAM1,CXCR4,PLAUR,DNAJC1,BTK,VAV3,CXCL2,P2RX7,CERCAM,CLEC10A	108	
Organismal Injury and Abnormalities, Renal and Urological Disease	renal lesion	renal lesion	7.38E-07	 	-1.024	 	0.103	CBX7,PCLO,VAC14,TPRG1,IL6,NPL,SLC39A8,POR,UPK3BL,GLB1,AJUBA,KEAP1,SMARCB1,ARHGAP39,TSC2,CAV1,DEFB132,PIGT,WASH3P,TSHZ2,SLC2A5,PTGIS,STK36,MTSS1,PPP1R1B,RANBP3,LARP4,PTPN3,IFNAR2,SHROOM4,NRDE2,PDLIM7,CDH5,BTG2,GCC1,ZDHHC1,KIAA1217,mir-21,EPHX1,CD163L1,APOE,NME1,PSMD7,FGF2,OSGIN1,IGSF1,CUBN,GNA11,ADIPOQ,CTDSPL,POFUT2,CCL2,ARFGAP1,PLIN2,IL34,ADORA1,CYP51A1,ALDH5A1,CCR1,S100A1,MECOM,TJP1,DGAT2,FOS,ARHGEF5,HNRNPH1,FLNC,ATP1A2,TAF1C,SOX9,MAP3K8,BMP6,RBP5,C11orf68,HAGH,ARSD,SESN2,ATP2B1,ABCA3,KLF6,DIRAS1,INTS1,GPC3,MYC,TGFBR2,LHFPL2,RHOB,GPR4,MOCOS,STAB1,TUBA1C,TEK,MARCO,CXCL8,LRBA,H19,MAST4,RILPL1,LAMA2,VEGFC,ERCC2,DCHS1,GUF1,FAAP20,BCL2L1,RPL8,AEBP2,BAP1,C17orf97,ESR1,VHL,S100P,SUN1,PTGFR,SLC1A4,RPH3AL,GSTT1,HNRNPK,IRAK1,RPL14,POLR1C,HLA-DRB1,AHNAK,TIMP1,SAA1,ERBB2,MCRS1,AGT,NUSAP1,TUBG1,GNAI1,G6PD,PLAUR,PYGB,CXCL16,XYLT2,RRAS2,POLR3B,VAV3,SMG7,CDC34,CXCL2,NNAT,PRUNE2,DDX11,SLC29A4,MSRB2,PCDH17,CDKN2C,APRT,LGMN,ZNF605,KIF21A,ANK2,PIK3C2B,CALCRL,NANOS1,ZC3HC1,CENPB,TUBB2A,MMP2,THBD,FAHD2B,RAE1,SH3GL1,CCDC136,AQP9,SRGAP3,CCZ1/CCZ1B,TIMP4,CCND2,BSG,EPB42,NPRL3,IL10RA,TRO,CCT3,RPL6,RSU1,MAP2K3,ALAS2,MAPK7,SFRP1,AIDA,CYR61,TMEM158,NOTCH1,PHLPP1,ADM,MME,SPTBN1,HIST1H1C,ADAM17,RALA,SERAC1,BTG3,TNFSF10,XPOT,FKBP1A,TBL3,ATP6AP1,IDH1,TRIB1,CADM2,MTOR,ANXA5,COL22A1,PRKCE,PTPRT,AHNAK2,NPRL2,PLAT,MYCN,PLXNA1,GSTM1,CD276,MGMT,DEFB1,SLIT2,AXL,GABRE,TRMT12,MRPL51,COL5A3,KRT8,LMO3,MCM2,PPP1R16B,SBF1,NOP2,BNIP3L,PTGS2,GABARAP,ATAD3A,ZFP36L2,FBN2,RGS1,SPNS1,CLEC3B,XPO5,SLC35F1,TPM1,TUBB,GUSB,METAP2,GSPT1,ETS2,ASXL2,ACP6,MCTP1,SIAH2,RET,FAM65B,PDK4,MFSD3,ACSL3,AXIN2,TRIOBP,SPP1,NUP155,SGCG,EGR3,NDUFAF2,INHBB,FLCN,STC1,PANK1,PPP2R1A,PKD1,SMOX,RAP1GAP,PRKCD,RGN,LMAN2L,XPNPEP1,TMOD1,MAP2K5,CDK5RAP2,RNPEP,ADAMTS7,PKM,ABL1,CDH23,HIF1A,ACOT7,FAM110B,EPHB6,HMOX1,MAN2C1,NFKBIA,PCK2,CSPG4,THBS1,FLNA,KCNMA1,FUBP3,KIT,ASAP3,CUL9,ZNF493,CHEK2,ASIP,TMEM132B,FAAH,LXN,SNAPC4,FRMD1,EPAS1,TPST2,SMAD7,LRRK2,ZBTB7C,NFKBIZ,CSF1R,TSPAN1,ACAT1,GLMP,KDR,XK,SLC47A1,MMP9,DHRS7B	322	
Endocrine System Disorders, Gastrointestinal Disease, Metabolic Disease	diabetic complication	diabetic complication	7.47E-07	 	 	 	 	MT2A,BMP4,AKR1C3,GMDS,CD36,TYRO3,CLEC3B,COL8A1,ABCG1,IL6,FRMD3,GSS,MYC,CRIP1,CTSH,ADRA1B,TEK,PTGIS,MT1G,SELE,SPP1,PTGDS,FOXC1,CRHBP,ADRA2A,COL6A3,NAGLU,ACACA,AKR1B1,COL3A1,COL7A1,MME,SULF1,PTGFR,APOE,CARS,COL4A5,BMP2,ADIPOQ,TNFSF10,CCL3,RAMP2,COL15A1,COL1A2,COL16A1,COL5A1,MTOR,COL6A1,DKK3,CD24,COL22A1,COL18A1,PTGER4,AGT,VCAM1,COL5A2,COL6A2,IMPDH2,COL12A1,ST3GAL6,HYAL1,GLIPR2,COL1A1,COL5A3,LDLR,EDNRA,FBP1,COL11A1,PTGS2,KDR,ADRA1A	71	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	abnormal morphology	abnormal morphology of heart ventricle	7.95E-07	 	 	 	 	ADRBK1,IL6,ATP2A2,BIN1,POR,IDUA,PLCE1,CCND3,GAA,RARA,CAV1,HEY2,CASQ2,ADRA1B,ELN,SGCG,LMNA,HBEGF,MMP2,DCHS1,DOCK1,TIMP4,NOL3,CCND2,MAPK7,MEGF8,TXNRD2,ADM,SPTBN1,APOE,ADAM17,ADIPOQ,ABL1,FKBP1A,MYH11,HIF1A,RAMP2,SHC1,HMOX1,EDN1,THBS1,LY6E,COL18A1,PTGER4,DHRS3,VCAM1,CXCR4,SMAD7,SLCO2A1,IGF2R,PLA2G4A,ZFPM2,NTRK3,SGCD,MMP9	55	
Cardiovascular Disease, Organismal Injury and Abnormalities, Tissue Morphology	size	size of infarct	7.95E-07	 	-1.408	 	-0.978	SESN2,CXCL12,SH3GLB1,C1QA,IL6,GPX3,PLA2G5,TSC2,CAV1,SIAH2,TXN,GSK3B,UNG,MIF,NOX4,MYDGF,PTGDS,THBD,ITGAM,NOL3,MDK,APOE,LEP,PPP1R1A,FGF2,GDF15,ADIPOQ,TNFAIP3,HIF1A,TNFRSF12A,TGM2,HMOX1,NFKBIA,CST3,ANXA5,RPS6KB2,PRKCE,MAPKAPK2,ABCC9,PRNP,PLAT,SRC,RNLS,UCP2,EGR1,GRN,RCAN1,PLA2G4A,LDLR,FCER1G,PTGS2,P2RX7,MMP9,CYP2C8,MAOA	55	
Cardiovascular Disease, Organismal Injury and Abnormalities	formation	formation of aneurysm	8.10E-07	 	-0.579	 	-0.118	RUNX1,ELN,APOE,LOX,SPP1,MMP2,SGCB,COL1A1,CBS/CBSL,TIMP1,MKL2,MGP,PTGS2,EFEMP2,KLF2,VHL,MMP9,AGT	18	
Cellular Growth and Proliferation	outgrowth	outgrowth of cells	8.34E-07	Increased	2.665	bias	0.016	CAMK1,BMP4,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,ABCC1,DNAJA3,TXN,TESK1,MATK,RND2,RIMS3,PRAG1,CHN1,GRK5,MMP2,TNK2,NINJ1,DOCK1,SRGAP3,CDH2,DVL2,CDH5,RTN4,ITGA1,MAPK7,CYR61,PTPRA,NRP1,SPTBN1,APOE,ADAM17,PLXNA3,BTG3,FGF2,CEBPD,VTI1B,VCAN,TGM2,EFNB2,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,GFRA2,SLIT2,RELN,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,CTSD,BRSK1,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,NGF,PTPRF,TNFRSF12A,SHC1,ARHGAP17,MARCH8,THBS1,KIT,ENPP2,NSMF,PRNP,SRC,VCAM1,PAK4,EPN1,SLC12A2,RTKN,LRRK2,SERPINE2,FAIM,KIF2A,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,CXCL2,KDR,TNFRSF19,MMP9	122	
Gene Expression	expression	expression of RNA	8.77E-07	 	0.511	 	-1.665	CBX7,AXIN1,TLE1,IL6,NPAS2,POLRMT,EIF3B,CCND3,CSE1L,AJUBA,TSC2,SMARCB1,DMAP1,ETS1,HEYL,PLAG1,DVL2,TCEA2,TRIAP1,PCBD1,EIF3K,EIF4EBP2,DDIT3,ADIPOQ,DDX3X,TIPARP,ATN1,GTF3C1,MECOM,MESP1,ID3,GPR183,AFF3,PIR,LYN,WBP2,SOX9,SOCS3,SFMBT1,HAVCR2,RGCC,ZFPM1,NARFL,CBX5,STC2,CPNE1,KMT5A,NOX4,H19,CBX6,POLR2H,BAMBI,LZTR1,ERCC2,EIF4E2,TXNRD1,AES,AEBP2,ZNF296,VHL,SLC11A1,UBE2I,ETV5,TEF,PEBP1,LITAF,PC,MRPL15,NELFB,ZP3,BMP2,INPPL1,HDGF,EDN1,STUB1,ERBB2,CRYM,PATL1,SRC,PREB,NLRP3,CSRNP1,PLAUR,SERTAD1,RBCK1,POLR2G,BTK,TSC22D1,ING1,MAP4K4,MED24,EIF3C,MSRB2,BMP4,CTGF,MST1,POMC,PPP4C,GSS,NCBP2,NR4A3,ITGA3,DMRT2,ZNF395,SPAG8,MKX,RARA,MED16,POLR2I,SFRP4,CDKN1C,NAB1,JUNB,HMGA1,MBD2,CREB5,CAPRIN1,NOTCH1,ANG,CNN2,FYN,ZFP36,ZNF234,BTG3,LEPR,HEATR1,SIN3B,FKBP1A,RUVBL1,RCOR2,MEOX2,H2AFZ,EIF4EBP1,MAFG,KLF9,KAT2B,JUN,CSF2RA,TUB,MEG3,HGS,ACVR1C,RPS24,PTPRK,TRIM28,EGR1,MED30,BHLHE22,CSRNP2,TMED2,SLIT2,BRMS1,RNASEK,OTUB1,ZNF593,MAMSTR,ARID4A,TNFRSF4,PFN1,CD36,CD4,LHCGR,ZNF91,H2AFY2,IKBKG,CAMK2D,PTGES2,ETS2,AMPH,GSK3B,C1QBP,RET,FZD2,FST,GNG2,FZD9,PAWR,ZMYND15,PUS1,INHBB,RASD1,ZNHIT1,ANKRD33,FLCN,ERP29,PRKCD,RARRES3,CRABP2,CDK5RAP2,SFRP2,PTMS,PA2G4,ATF5,ZNF174,NGF,NELFE,HINT1,NFKBIA,DKK3,USP47,SMO,NCL,KCTD1,MAPKAPK2,IFRD1,CHEK2,ADRB2,EPAS1,BHLHE41,ATP2C1,PARP10,EDF1,IL18RAP,FAF1,CIART,COL1A1,EBF1,RPS27L,GLMP,MYPOP,CPEB1,SLIT3,ASCC1,SPI1,SLC9A1,ODC1,NKAP,ZNF263,GATAD2A,EGR2,CTSH,KEAP1,MYADM,LUM,CAV1,ATF4,EBF2,HES6,HIPK2,KAT2A,MYL3,STK36,PPP1R1B,TNFRSF10B,MAD2L2,IFNAR2,HAX1,HSPA8,PYGO2,MN1,MRPL17,PPP1R15A,BTG2,ATMIN,GAPDH,CD86,SQSTM1,SAMD4A,DEAF1,RNF10,APOE,NME1,NACC2,ZNF205,FGF2,IGSF1,CEBPD,DUSP22,CTDSPL,SLC31A2,IFI27,TGM2,RITA1,DUSP5,CCL2,IRF2BP1,GADD45A,IRF2BPL,SOS1,DAB2,PIK3R2,ASPH,TRIM29,RAD21,HEY1,CCR1,S100A1,MED20,ZNF580,MRPL12,RGS16,TOB1,TRIB3,GRN,FOS,LY96,ZFPM2,MYOC,NR4A2,LDLR,NTRK3,MBD3,TAGLN,TAF1C,TP53BP1,MAP3K8,PIN1,BMP6,ID4,RFXANK,PTTG1,ITGB1BP1,MBP,HSPA1A/HSPA1B,KLF6,OGFOD1,ABCG1,AP2A2,CEBPG,MYC,TGFBR2,HSPA4,RHOB,MAP2K2,CHMP1A,POLR3C,ATF3,MYDGF,BTG1,ZNF282,THRA,KLF4,FOSB,CBX1,CHURC1,DUSP1,BUD31,ALDH1A2,THAP7,IGFBP3,FZD5,H1F0,MDK,DNAJB6,CCPG1,ESR1,RUNX1,PTGFR,TPR,ABCF1,ATF6,GTF3A,CCL3,HNRNPK,GCDH,ETV6,IRAK1,SHC1,TRIM6,TIMP1,MKL2,LRPPRC,TOX2,AGT,SLC20A1,VCAM1,TUBG1,NQO1,SMAD6,DNAJC1,ZPR1,NFE2L1,RCAN1,HRSP12,KCTD13,DGKQ,PHF19,VAV3,SNAPC2,RPS6KA4,ISG20,CAMK1,APOB,SGK1,TGFBR3,MAF,ELANE,HRAS,CDKN2C,MIF4GD,SATB2,NCOA7,LPIN1,ZHX2,ANK2,DNAJA3,TXN,PKIA,HEY2,NANOS1,DBP,RRBP1,TAF9B,LDOC1,RAE1,CDH2,NR1D1,ADM2,RPL6,MAP2K3,RAMP3,LRP8,MAPK7,SFRP1,CYR61,MME,HIST1H1C,SCAP,MSC,RALA,TCEA1,PSMB10,TNFSF10,MYH11,DCLK1,ID1,DCLK2,MTOR,TADA3,DHPS,SEC61A1,CCL3L3,SOCS2,PRKCE,PSMD14,SARS,MYCN,SOX7,TWNK,EPB41L4B,YBX2,MRPL51,TF,S100A9,LIMS1,TRAPPC2,SPRY2,PEA15,S1PR1,IGF2BP2,NR5A2,DVL3,CBX4,ZFP36L2,MAPRE3,FZD7,TFG,FNIP2,XPO5,LIPE,UTP4,TAF10,LOC102724828/MRPL23,MTCH2,CYP26B1,TNIP1,ASXL2,SDPR,OSR1,EIF5,NEO1,KPNA2,LTBR,LPIN2,KLF2,DDX41,EIF2AK1,MIF,SPP1,GPS2,LMO4,NPM3,LMNA,FOXC1,PKN1,EPRS,LMCD1,ITGAM,PKD1,MAP2K5,DRAP1,SPX,LEP,NFIX,ERN1,BCL2L12,VAPA,C1QTNF1,ABL1,RBBP8,TNFAIP3,TET1,MRPL2,IRF3,HIF1A,CDKN2B,RAMP2,PDCD4,SOX17,NFX1,AEBP1,FLNA,FUBP3,CLOCK,RPS6KB2,KIT,ARHGEF2,NR2F6,PTGER4,ASIP,SNAPC4,TAF6,CXCR4,SMAD7,ZBTB42,ZBTB7C,NFKBIZ,NDUFA13,ENO1,WARS,PBX3,LPAR1,ELK1,RCAN2,P2RX7,CARM1	536	
Immunological Disease	hypersensitive reaction	hypersensitive reaction	8.83E-07	 	0.314	 	-0.725	PLIN1,GARS,POMC,SPI1,ZNF395,LGMN,GNA15,AHCY,MCL1,SELE,MAD2L2,FLOT1,JUNB,BRF2,THBD,ALCAM,mir-21,MME,FYN,APOE,ADAM17,ZFP36,LEPR,GNA11,ADIPOQ,TNFSF10,FKBP1A,CASP4,RUVBL1,H2AFZ,IFI27,MTOR,JUN,CCL2,GADD45A,CCL3L3,CSF2RA,CST3,IL17D,ANXA5,SOCS2,STIM1,LBP,P4HA2,FCER2,CCR1,DEFB1,F11R,PLA2G4A,NR4A2,S100A9,LYN,FCER1G,FKBP4,MS4A2,PTGS2,ADRA1A,NAGK,TNFRSF4,ADRBK1,CD4,HAVCR2,MBP,HSPA1A/HSPA1B,FCER1A,TPM1,STARD7,PTGES2,ALDH3A2,DDX41,ADRA1B,CPNE1,PDK4,CXCL8,MIF,SPP1,HNMT,TRIOBP,SHARPIN,PSME2,CAPG,PTGDS,RAB34,BCL2L1,H3F3A/H3F3B,CORO1B,ADRA2A,DUSP1,IDO1,CCL18,UBE2I,SRM,SFTPD,TNFAIP3,GPR34,SMPD1,NGF,EPHB6,HLA-DRB1,NFKBIA,CCL13,AHNAK,TIMP1,FLNA,MCAM,DUSP10,KIT,S100A8,PTGER4,ADRB2,SRC,NLRP3,CXCR4,NFKBIZ,IL20RB,ENO1,ACADVL,CYTIP,CAT,MMP9,FCGBP	121	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development	development	development of connective tissue cells	8.98E-07	 	-0.609	 	-1.655	SOCS3,BMP4,HRAS,MST1,IL6,MYC,TGFBR2,SATB2,LGMN,CAV1,TXN,GSK3B,CXCL8,SFRP4,MIF,AXIN2,FST,KLF4,MAPK7,SFRP1,SQSTM1,NOTCH1,mir-21,RUNX1,SULF1,MAP7,ADAMTS7,SLC4A2,SFRP2,FRZB,FGF2,BMP2,ABL1,ADIPOQ,CDK4,TNFSF10,CCL3,VCAN,PDCD4,NFKBIA,JUN,EDN1,CCL2,CCL3L3,CST3,FLNA,SNX10,FNDC5,KIT,S100A8,SULF2,HEY1,SRC,ADRM1,ZNF521,EGR1,SMAD7,F13A1,SCIN,NUP210L,CSF1R,CYP1B1,THNSL2,SH3PXD2A,GRN,FOS,PLA2G4A,EBF1,LDLR,DHCR24,WAS,SPARC,SOX9,COL11A1,PTGS2	75	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of myeloid cells	9.10E-07	 	-0.655	bias	-3.657	RARRES2,PFN1,CD4,SPHK2,ELANE,CTSG,CXCL12,MST1,SERPINA3,SPI1,HOXA9,RHOB,CXCL14,VEGFD,C1QBP,CSF3R,ELN,CXCL8,MIF,CMKLR1,SELE,SPP1,PLEC,VEGFC,ANO6,FLOT1,CAPG,NINJ1,TPSAB1/TPSB2,AQP9,ITGAM,PIP5K1C,YARS,ITGA1,MDK,APOE,FYN,SFTPD,LITAF,DAPK2,NGF,CCL3,G6PC3,CCL13,CCL3L1,EDN1,CCL8,CCL2,CCL3L3,THBS1,CST3,CSF2RA,SAA1,S100A8,STIM1,ERBB2,LBP,MAPKAPK2,ADORA1,HCAR2,PRNP,CCR1,THBS4,C5AR1,MMP28,ANGPT1,CXCR4,CD69,LRRK2,PLAUR,DEFB1,SLIT2,CSF1R,GRN,HP,SWAP70,LDLR,S100A9,WAS,VAV3,LSP1,LYN,FCER1G,EDNRA,CXCL2,NCKAP1L	86	
Neurological Disease	epilepsy	epilepsy	9.23E-07	 	-1.849	 	-1.183	NNAT,CH25H,RGS1,SOCS3,CYTOR,NCDN,CA4,HSPA1A/HSPA1B,TYRO3,CA5B,SNTA1,CA12,CACNA1H,C1QB,SLC9A1,NR4A3,IKBKG,EGR2,ABCC1,NPTX2,ADRA1B,MCL1,STXBP1,CALCRL,ATF3,DBP,IER2,EGR3,PPP1R1B,JUNB,LMCD1,HSPA8,FOSB,SLC25A22,DUSP1,CTSB,ME2,AARS,CYR61,SYN1,TEF,EPHX1,ADM,APOE,FYN,GADD45B,ZFP36,CEBPD,SLC1A3,MIR22HG,NGF,SLC2A3,DTNA,CA3,TRIB1,HMOX1,DUSP5,ANGPTL4,JUN,GBA,TIPARP,PNPO,GADD45A,KCNMA1,SRGN,LOC102724428/SIK1,IFRD1,CRYM,ALDH5A1,ADRB2,CCR1,SIGMAR1,CXCR4,EGR1,C9orf3,RGS16,ANOS1,GFRA2,RELN,SERTAD1,ST3GAL3,GABRE,CSTB,SERPINE2,FOS,LDLR,ITPA,SPRY2,ATP1A2,AP3M2,PTGS2,SYN2,ADRA1A,CYP2C8	94	
Hematological System Development and Function, Inflammatory Response, Tissue Morphology	quantity	quantity of phagocytes	9.35E-07	 	-0.692	 	-1.042	APOB,C1QA,IL6,SLC35C1,SPI1,HOXA9,MFAP2,ITGA3,LUM,MGAT4B,MCL1,CMKLR1,CLEC4G,SELE,MFAP5,HBEGF,THBD,HAX1,CD86,CNN2,APOE,ADAM17,ZFP36,DDIT3,LEPR,NQO2,GDF15,ADIPOQ,TNFSF10,G6PC3,TGM2,ID1,TRIB1,CES1,GBA,CCL2,CCL3L3,SORBS1,IL34,PRKCE,LIPG,PLAT,CCR1,TSTA3,C5AR1,TYROBP,HDC,GPR183,SWAP70,LDLR,TF,CBS/CBSL,S100A9,WAS,LSP1,LYN,FCER1G,NDST2,ZFP36L2,ST3GAL4,ARID4A,SOCS3,TNFRSF4,CD36,HAVCR2,PLA2G15,LHCGR,TGFBR2,IKBKG,ADGRF5,PLCE1,CXCL14,STAB1,LTBR,NEDD4L,BIRC3,TEK,STX11,CSF3R,CXCL8,MIF,SPP1,ATF3,DOK2,FZD9,THRA,ITGAM,PRKCD,IGFBP3,IDO1,MDK,RUNX1,LITAF,SFTPD,LEP,ABL1,TNFAIP3,TET1,SMPD1,NGF,CCL3,CDKN2B,SHC1,HINT1,NFKBIA,TIMP1,THBS1,KIT,S100A8,MAPKAPK2,AGT,SRC,VCAM1,NQO1,ST3GAL6,CSF1R,FASTK,ACAT1,C6,MMP9	120	
Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	liver lesion	liver lesion	9.45E-07	 	-0.712	 	0.572	PCLO,ASS1,GARS,TLE1,LRRN4CL,SLC39A8,POR,GLB1,PPRC1,TSC2,VIT,RBM38,CLEC4G,DDIT4,SLX4,DVL2,CDH5,ALCAM,ATG101,KIAA1217,mir-21,FHL1,LTBP2,DDIT3,SLC1A5,KIAA1211L,TMEM79,ADIPOQ,C1R,TIPARP,LLGL1,ATN1,MTSS1L,RNF157,ID3,PAMR1,GPR183,PDZD2,GPAM,MTHFD1L,AFF3,CBS/CBSL,WDR86,TBC1D8,TCTEX1D2,CA4,HAVCR2,DNAJC15,INTS1,LHFPL2,STRN4,STC2,NDUFA10,EEF1E1,MTMR2,NSMAF,BIRC3,TEK,RASGRP2,ADAMTS1,KANK1,BCL2L1,H3F3A/H3F3B,NAGLU,SUN1,ETV5,CARS,KCNK3,ZNF252P,NHP2,CLUAP1,GIMAP6,HDGF,THYN1,COL6A1,F8,C16orf59,IGSF8,ELMOD3,NLRP3,FAAP100,PLAUR,SAA2,SNX27,FRMD4A,CLEC16A,BTK,ACADVL,ZNF544,SPARC,ING1,CXCL2,MED24,MAP4K4,RER1,ASPSCR1,SNTA1,CA12,ABHD1,RNF38,SGPL1,TMEM268,PRG4,ZNF605,SPAG8,FAM124B,MCL1,POLR2I,PPIL6,UBXN6,CDKN1C,NAB1,SV2B,HIGD1B,TIMM17B,PLEC,HBEGF,CREB5,FAM193B,IRX5,MS4A14,NCLN,KIAA0368,NOTCH1,EOGT,COL3A1,SORL1,SUSD2,FCGRT,ABI3BP,ZFP36,LEPR,ZNF234,NQO2,SIN3B,ST6GALNAC4,FKBP1A,COASY,CADM2,CCL8,ENTPD6,DIP2B,DPCD,TUB,COL22A1,TXNL1,PI16,HGS,AHNAK2,LIMCH1,RPS24,NAP1L4,CD276,FCRLB,STAMBPL1,EGR1,COL12A1,TRIM28,DAAM1,MED30,RELN,ACLY,DHCR24,CYP4F22,SBF1,KLHL35,CELF2,TMEM63B,PTGS2,AOX1,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,FAM127B,ZNF91,SLC6A16,RSPO3,IKBKG,CNDP2,PLCE1,DHTKD1,COMT,MCTP1,NMNAT2,GOT1,FAM193A,USP36,FAM45A,SLC4A7,PAWR,ATP10A,ALAD,GALNT13,INHBB,COL6A3,FRYL,SCRIB,TSTD1,RCE1,UVRAG,FPR3,PPIP5K1,NGF,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,CYGB,SULF2,ASAP3,TMEM104,PARP10,TANC2,LRRK2,DAAM2,ANO2,SYBU,COL1A1,FAF1,PAG1,FAM46A,NCKAP1L,MYPOP,XK,MPV17,SLIT3,SVEP1,SYTL2,CLSTN2,CCDC88C,ASCC2,SLC35C1,SPI1,ATP2A2,ODC1,RNASE4,CAAP1,NPL,RCL1,OGFOD3,PPP1R3F,GPRC5C,MYADM,WDR47,SPATA18,MRPL24,PLD3,MTSS1,TIMM44,TMEM98,TNFRSF10B,CARMIL1,LAMC3,OSGIN2,SMOC2,WDR81,SLC7A10,MN1,PPOX,PPP1R15A,P2RX6,CHD1L,SQSTM1,ADIPOR2,IGSF10,PTPRA,TRAPPC5,FKBP2,APOE,RNF10,NME1,TTLL3,FBXO10,SFXN4,ZNF205,IGSF1,CUBN,SCUBE2,HS2ST1,CDK4,CTHRC1,CCL2,ARFGAP1,ALG8,ASPH,ARMCX1,ADORA1,RAD21,CYP51A1,CCR1,S100A1,BTNL9,HELZ,TJP1,STOML1,DGAT2,PTCD1,SAA4,TBC1D13,UBL7,MYOC,ZFPM2,LDLR,NTRK3,SERPINH1,ARHGDIA,BMP6,PPIL1,CPXM1,ID4,HAGH,KTN1,MEGF9,ABCA3,RTN1,ACO2,TYMP,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GDE1,GYPE,NUPR1,STAB1,LILRB5,KIF25,RPAP1,NBAS,TEX264,FMO2,STARD5,VEGFC,ZNF282,THRA,KCNK12,DCHS1,SMUG1,CDC42BPB,TLN2,ABCA8,CHURC1,LRRC25,VPS37A,ESR1,LRRC47,PMEPA1,MAST2,PTGFR,ERAP2,SLC1A4,CDC20,SRPX,SCARA5,MECR,ZSWIM3,NEURL4,GSTT1,VPS4A,SLC2A3,IRAK1,AHNAK,TIMP1,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,ATP13A2,SLC20A1,VCAM1,NUSAP1,AP1S2,XRN2,GNAI1,ZFPL1,BSCL2,PSME3,NFE2L1,ATIC,FAIM,SH3PXD2A,SLK,XYLT2,PHF19,VAV3,CAT,TBC1D7,GAPVD1,SGK1,SH3GLB1,PCDH7,NCOA7,SLC4A3,LPIN1,CLCNKA,ABCC1,RPS2,ALPK1,TMEM9B,NAT10,SERINC1,MMP2,IER3,SCNN1D,LONP2,UBQLN4,DOCK1,SRGAP3,YARS,TRO,RPL6,LRP8,PDGFD,ITGA7,ALDH4A1,RALA,PDDC1,NT5C,PFKL,VCAN,SERTAD4,DCLK2,TRIB1,MTOR,WDFY1,ALDH1A3,DAP3,NAALAD2,EPS15L1,AKR1B15,LPP,SARS,COL18A1,NCKIPSD,PLOD3,DNAH6,CYP11A1,SOX7,GSTM1,CCDC130,EPB41L4B,PCDH9,POLD1,LAMP2,RBM6,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,CYP2C8,FZD7,MVD,C10orf54,CYTOR,ADRBK1,FNIP2,DYNLT1,COBL,CCNL1,TMED5,MBNL3,LARS,PRND,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,DDX41,PTX3,CSF3R,MGRN1,SPP1,SGCG,ITPR2,LMNA,MYOF,MARS,DPP9,GSR,TRAPPC9,R3HDM4,RGN,THSD7B,RNPEP,COL7A1,LEP,FLRT2,C1QTNF1,BCL2L12,UBASH3B,PNMAL1,RGS12,RAMP2,AADAC,FLNA,HSD11B2,ZNHIT2,RNF144B,MYO16,TMEM132B,SNAPC4,SPOCD1,FRMD1,PHOSPHO2,AP3D1,VWCE,SMAD7,CSF1R,TRMT61A,LRP1B,OLFML2B,NDNF,ZNF585A,MMP9,CARM1,CBX7,TOMM40L,RPE,AXIN1,TPRG1,IL6,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,TMEM219,TNFRSF21,SLC2A5,COMP,COCH,TMEM203,GFM1,ERICH1,PTPN3,PTOV1,CTSB,EPHX1,CD163L1,EVA1B,COL4A5,HSDL1,GADD45B,DDX3X,SPON1,DTNA,ABCC9,GTF3C1,UCP2,MECOM,ZNF521,KIAA1549L,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,GCNA,MXRA5,SOCS3,ARSD,ANKMY1,FCER1A,ZFPM1,AP1B1,GPC3,CEP104,CTSD,TSEN15,ARHGAP20,ACTG2,KMT5A,ELN,CXCL8,NOX4,STXBP1,MAPK8IP2,CBX6,RIMS4,H6PD,FIG4,AKR1B10,TXNRD1,FCN3,ADRA2A,CCDC80,GSDMC,TNS1,SLC11A1,VHL,SULF1,PC,COL6A6,ALDH2,DHCR7,SNX16,STUB1,ERBB2,NDUFV1,PKP1,COL6A2,IPO4,G6PD,AP3B2,RBCK1,POLR3B,COL11A1,PRUNE2,KCND2,RAN,PCDH17,MST1,GHITM,NR4A3,EVI5L,LGMN,MKX,RARA,BAALC,KIF21A,MED16,HADHA,ZC3HC1,DKC1,MBD2,ROR1,VPS26B,BCAP29,TSR3,FARSA,AAAS,GAMT,EPB42,PDE1B,FAM71E1,RTN4,ME2,ANG,AKAP12,SQLE,HEATR1,PPP1R3C,SLC1A3,HYOU1,GOLGA3,ATAT1,TRPT1,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,GPIHBP1,TIGD5,C20orf96,ENAH,CELF1,RPUSD3,CES1,JUN,PDE3B,CD24,MORN4,PLXNA1,CEP164,NOL6,PTPRK,ARHGAP4,PAICS,LRSAM1,NBEA,SLIT2,AXL,MRPS18A,GABRE,GBP4,SLC48A1,RHBDD2,GTPBP3,BRINP2,GALE,BMF,ANXA3,CILP,NENF,PFN1,FARP1,FAT1,LAMTOR2,CD36,UNC5B,MAP1B,WDR5,CAMK2D,MYOM1,PCYT2,AMPH,GSK3B,RET,HLA-F,EPB41L1,C7orf50,MFSD3,PHACTR3,STX11,HK1,FERMT3,PTPRE,HNMT,TRIOBP,SHARPIN,ICA1,PCDHA1,MAPK8IP3,GPAA1,ZNHIT1,FLCN,KIAA0922,RAP1GAP,EXOSC4,RARRES3,CD14,IDO1,TBC1D16,XPNPEP1,ARL2,SPIRE1,SRM,SH3RF3,PA2G4,ATF5,SLC4A11,CD55,NFKBIA,SMO,CFB,STK24,IFRD1,NCL,ATP5I,CHEK2,RHBDD3,COL5A2,METTL1,VSIG4,CIART,TMEM2,GLMP,GBE1,NUCB2,KDR,DHRS7B,KLHDC8B,ANKRD35,WBSCR22,CLIP1,ADCK1,EIF4EBP3,KEAP1,IQCC,KIF1A,ST6GALNAC2,KANK3,HES6,HIPK2,TM6SF1,SELE,STK36,PPP1R1B,TMEM201,ANO6,SMG5,MASP1,THOP1,NPY5R,IFNAR2,TFPI2,HSPA8,TMEM127,CARD9,EVPL,IFT122,CTSA,VARS2,CCDC178,ITGA1,TULP3,MUSTN1,SAMD4A,CHCHD10,FGF2,OSGIN1,SEMA6A,THOC3,ZBTB9,MMP25,SLC35B2,COL16A1,TGM2,GADD45A,CHDH,SORBS1,OSBPL11,CSNK2B,PIK3R2,FCGR3A/FCGR3B,MAPKAP1,NINL,TOB1,GLG1,FOS,PLA2G4A,HP,SELM,NRXN2,FLNC,ATP1A2,MBD3,ZCWPW1,SLC22A18,TMEM177,MAP3K8,TTYH3,SEMA3C,ABCC3,C11orf68,PTER,ABCB6,MT2A,FOXRED1,ATP13A1,PTTG1,MBP,ABCG1,HSPA5,AP2A2,PADI4,GPR4,KCNAB1,FAR2,CHTF18,CAST,PDZRN3,KCNJ8,MAST4,LAMA2,ENKD1,CAPG,OSBPL7,CYB561,KCNG1,ALG3,SOBP,IGFBP3,AGAP3,MEGF8,TXNRD2,PPAN,LRRC8B,UBXN1,NMT1,TPR,CADPS2,ATF6,KIFC2,HNRNPK,REXO2,MSRB3,SHC1,SLC19A3,NET1,SAA1,ENPP4,MKL2,ENPP2,LRPPRC,MCRS1,MRPL40,LONP1,AGT,ZNF135,ZNF358,NQO1,TUBGCP2,ADGRG1,PIGB,TACC2,KIF5B,ASTN2,HEPACAM,NOP16,SMG7,IVD,DNM1L,PNPLA6,COQ9,SLC29A4,CADM3,APOB,WDR45,HRAS,MYRIP,DGCR6L,PEG10,PEX16,CCNB1IP1,GAA,ANK2,REEP2,IRS2,TXN,EYA2,ARHGEF4,CALCRL,NDRG1,PCSK5,RRBP1,THY1,TNK2,FAM129B,PLOD1,CTPS1,LDOC1,NR1D1,BSG,PTPRB,CDRT1,ADAMTS18,GLUL,MAP2K3,ZER1,SFRP1,CYR61,ADM,MME,SPTBN1,MSC,ADAM17,GRB14,NID2,UHRF1BP1,TNFSF10,TTC1,DCLK1,RPP40,IDH1,UCHL1,COL5A1,EFNB2,CCL3L3,PTS,STARD13,CLMN,PSMD14,KIAA0391,LDLRAP1,RASSF5,LBP,PCBP2,PTPRT,AMFR,PI4KA,MYH1,MYCN,STK19,VPS18,ADRM1,ANGPT1,TWNK,TYROBP,IMPDH2,MGMT,DPAGT1,WDR12,CYP1B1,RHPN2,KRT8,PLEKHG6,TF,PPP1R16B,CNN1,ADCY1,DENND1A,ZSCAN18,S1PR1,CBX4,FBN2,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,TFG,DCAKD,SPHK2,CXCL12,SDC4,DCAF10,FRMD3,CCT8,PLEKHG4,PARVB,TNIP1,SDPR,BRSK1,SLC7A5,PUF60,PDK4,EIF2AK1,PNMA2,MIF,AXIN2,TMIE,TEX2,SNRK,PKN1,EPRS,LMCD1,EFS,PPP2R1A,ITGAM,ERCC1,SMOX,GNL3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,SLC7A1,TET1,TNFAIP3,QPRT,SMPD1,MYLK,IRF3,ITGA10,SIL1,HIF1A,ACOT7,CDKN2B,FAM110B,PRKCSH,COL1A2,SEPHS2,NKD2,NFX1,HMOX1,AEBP1,PCK2,KCNMA1,C7,POLN,KIT,ARHGEF2,NR2F6,CUL9,ALPL,STK40,HMGCS1,ACTN1,PRNP,FAAH,CYP27A1,CXCR4,COPS7A,SCIN,ZBTB7C,SLC7A8,CCDC3,WARS,DIP2C,LPAR1,EDNRA,ELK1,RTN3	1089	
Cellular Movement	invasion	invasion of breast cancer cell lines	9.70E-07	 	1.617	 	-0.274	PTTG1,TGFBR3,KLF6,CXCL12,MST1,CBX5,SLC9A1,MYC,TGFBR2,PARVB,ITGA3,CSE1L,KEAP1,CAV1,IRS2,GSK3B,MATK,ETS1,SPP1,ADAMTS1,GSDMB,MMP2,MBD2,ROR1,FOXC1,CDC42BPB,TIMP4,SDCBP,NOL3,BSG,GIPC1,FSCN1,CTSB,DNAJB6,ESR1,mir-21,LOX,LEP,FGF2,BMP2,ABL1,TNFSF10,RUVBL1,HIF1A,ENAH,EPHB6,ID1,RAB5A,MTOR,NFKBIA,ANGPTL4,JUN,EDN1,NET1,TIMP1,MCAM,ACSL4,ERBB2,PI4KB,ADRB2,SRC,CTSK,PAK4,PARVA,BHLHE41,TJP1,CXCR4,PLAUR,PRMT1,FAF1,KRT8,PLEKHG6,WBP2,SPARC,PTGS2,BMP6,MMP9	77	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease	ovarian cancer	ovarian cancer	9.80E-07	 	 	 	 	PCLO,VAC14,IL6,NPAS2,POR,CCND3,FBL,PTGIS,SLX4,C14orf79,ALCAM,EPHX1,COL15A1,SYNM,DDX3X,DTNA,RABL6,TIPARP,GTF3C1,MECOM,KIAA1549L,CDO1,IGF2R,AFF3,KIF7,SWAP70,TBC1D8,WBP2,LIG1,MICALL2,RGCC,AP1B1,CCT5,TUBA1C,CXCL8,H19,TJP2,ERCC2,TXNRD1,BCL2L1,CRHBP,BAP1,SLC11A1,IGFBP4,FEM1A,CLUAP1,COL6A6,PHLDB2,HLA-G,ERBB2,SRC,NLRP3,PLAUR,RRAS2,ANO3,COL11A1,CERCAM,ASPSCR1,CTGF,GMDS,CMTM4,TYRO3,PCDH17,POMC,ACP5,ITGA3,EVI5L,MGAT4B,EFL1,PIK3C2B,CMKLR1,CAPN6,ATP8B4,HBEGF,TMEM267,JUNB,HMGA1,PARP3,CREB5,SH3GL1,DPH2,ACAD11,MS4A14,NCLN,RTN4,NOTCH1,ANG,COL3A1,NRP1,GSTM5,RP9,HEATR1,SIN3B,THBS3,CORO2B,STOM,JUN,KAT2B,PDE3B,ENTPD6,DIP2B,CD24,COL22A1,NPTXR,FUK,PLXNA1,MYOM2,LRSAM1,NBEA,SLIT2,NTM,DHCR24,PTGS2,ATAD3A,TM4SF1,ZFYVE19,LRFN4,TFF3,FARP1,FAT1,CLEC3B,CLIP3,FAM173A,ALDH1A1,ETS2,COMT,DHTKD1,MCTP1,PGP,GSK3B,HK1,KLHDC3,PAWR,MAPK8IP3,COL6A3,SCRIB,IDO1,SLC4A11,PTPRF,SSU72,THBS1,HSPE1,CFB,GOT2,MAPKAPK2,CHEK2,ADRB2,TMEM104,EPAS1,C9orf3,TANC2,LRRK2,CIART,C2orf88,PLEKHH1,EPHB3,KDR,NIPA2,MAP6,ODC1,FADS3,OGFOD3,EGR2,KEAP1,ARHGAP39,MGP,KANK3,MTHFD2,SPATA18,ALDH3A1,TSHZ2,RNF121,SELE,MFAP5,TNFRSF10B,FLOT1,TFPI2,TMEM127,TNPO2,NRDE2,EVPL,VARS2,GAPDH,ITGA1,IGSF10,APOE,FBXO10,NACC2,FGF2,CUBN,GDF15,CDK4,CTDSPL,IFI27,TGM2,DUSP5,CCL2,CS,SORBS1,DAB2,ADORA1,TBC1D10B,HCAR2,RAD21,MED20,NINL,CUL7,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,ZFPM2,LDLR,TMEM106C,SLC22A18,SEMA3C,ABCC3,ATP13A1,ABCA3,PARP2,CES2,STARD7,MYC,TGFBR2,GPX3,GPR4,CXCL14,STAB1,LILRB5,CAST,FMO4,PKP2,GM2A,LAMA2,TLN2,ABCA8,GIPC1,APCDD1,ALDH1A2,IGFBP3,DNAJB6,MEGF8,LRRC47,ESR1,S100P,RUNX1,MAST2,ERAP2,FAM107A,TPR,ZSWIM3,CCL3,GCDH,RAP1GDS1,MSRB3,POLR1C,TIMP1,MCAM,LOC102724428/SIK1,LRPPRC,ENPP2,MCRS1,VARS,PSAT1,NUSAP1,VCAM1,TUBG1,EMD,GATSL3,LARP6,ATIC,CXCL16,PMP22,VAV3,LPAR5,ALKBH3,APOB,CDKN2C,RAPH1,GTF2IRD1,HOXA9,ABR,CSTF2,IRS2,EYA2,RRBP1,TUBB2A,MMP2,TNK2,RAD51D,RAE1,CDH2,MS4A4A,MS4A7,TRO,SPINT2,LRP8,ZER1,CYR61,MYEOV,SPTBN1,HIST1H1C,HIST2H2AA3/HIST2H2AA4,ADAM17,CHCHD6,WASF3,TTC1,DCLK1,KHDC1,VCAN,COL5A1,EFNB2,MTOR,CMTM8,TBCD,TPO,COL18A1,PTPRT,CYP11A1,GSTM1,VPS18,ANGPT1,MGMT,MVB12A,TF,PLEKHG6,CDK20,MS4A2,PEA15,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,TPM1,ARG2,TUBB,KPNA2,MYO10,PDK4,CSF3R,AXIN2,MIF,SPP1,LMNA,MYOF,STC1,PPP2R1A,ERCC1,PKD1,THSD7B,AKR1B1,RNPEP,COL7A1,ADAMTS7,LEP,EPB41L3,FLRT2,CUTA,PKM,ABL1,TET1,CDKN2B,FAM110B,EPHB6,COL1A2,EVC,PCK2,CSPG4,FUBP3,HIST2H2AC,KIT,NEK7,RNF144B,STK40,PRRT3,PI4KB,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,CXCR4,ENO1,ITPA,UBA1,RTN3,MMP9,ATP6V1B2,SHMT2	391	
Cell Death and Survival	apoptosis	apoptosis of epithelial cells	9.84E-07	 	-1.028	 	-0.408	SOCS3,TFF3,ADRBK1,SGK1,CD4,UNC5B,SPHK2,HRAS,MST1,POMC,IL6,MYC,MIA,TNIP1,IKBKG,ALDH1A1,GSK3B,HIPK2,BIRC3,MCL1,CXCL8,NDRG1,TNFRSF10B,MMP2,BCL2L1,CDH2,ERCC1,PKD1,PRKCD,CTSB,RGN,SFRP1,ESR1,mir-21,SPTBN1,LEP,GADD45B,FGF2,NQO2,GDF15,ADIPOQ,TNFSF10,SMPD1,MYLK,IRF3,NGF,TGM2,EFNB2,ID1,SHC1,ALDH2,MTOR,NFKBIA,JUN,EDN1,GADD45A,TIMP1,SAA1,ERBB2,NCL,MAPKAPK2,PLAT,SLC20A1,MYCN,SRC,NLRP3,EGR1,PLAUR,FAIM,RBCK1,PLA2G4A,KRT8,LDLR,CBS/CBSL,BMF,CAT,PEA15,S1PR1,FKBP4,SPARC,PTGS2,BMP6,P2RX7,MAOA	84	
Free Radical Scavenging	production	production of reactive oxygen species	9.89E-07	 	-1.073	 	-2.201	MSRB2,CTSG,TRAP1,HRAS,SERPINA3,IL6,SPI1,MTUS1,CYBA,ABCC1,TSC2,CAV1,ETS1,SELE,NLRX1,CARD9,CDH5,NCF2,RTN4,ITGA1,SQSTM1,BACE2,FTH1,FYN,APOE,DDIT3,FGF2,ADIPOQ,IDH1,TGM2,MTOR,CST3,PRKCE,COL18A1,FCGR3A/FCGR3B,SIGMAR1,UCP2,C5AR1,TYROBP,GRN,PLA2G4A,IMMT,CBS/CBSL,TAGLN,LYN,FBP1,ARHGDIA,MAP3K8,AFG3L2,PTGS2,MAOA,CD36,CXCL12,FCER1A,ALDH3A2,HK1,CXCL8,NOX4,SPP1,APLNR,HSPA9,THRA,ARSA,TXNRD1,BCL2L1,ATPIF1,ITGAM,PRSS23,SMOX,PRKCD,CD14,SLC25A10,AKR1B1,TXNRD2,SFTPD,LEP,BMP2,ABL1,MYLK,SMPD1,CCL3,NGF,HNRNPK,HMOX1,SHC1,NFKBIA,CCL13,EDN1,CFB,RPS6KB2,S100A8,LONP1,AGT,PRNP,FAAH,SRC,VCAM1,LCLAT1,G6PD,LOC102724788/PRODH,CAT,DNM1L,CXCL2,P2RX7	104	
Cancer	transformation	transformation of fibroblast cell lines	1.00E-06	Increased	2.246	bias	0.218	ITSN1,PTPN23,TFG,PTTG1,CD4,TYRO3,KLF6,HRAS,SERPINA3,DIRAS1,BIN1,ODC1,MYC,RHOB,CCND3,GPR4,RET,RASGRP2,ETS1,ATF3,JUNB,HMGA1,FOSB,SH3GL1,MN1,PRKCD,BTG2,MAPK7,ESR1,mir-21,MAP2K5,FTH1,ADM,RUNX1,LOX,FGF2,TPR,ABL1,CDK4,CDKN2B,ETV6,SH3D19,SHC1,MTOR,NFKBIA,JUN,CSF2RA,SOS1,SMO,PRKCE,ERBB2,ASPH,LPP,FCGR3A/FCGR3B,HEY1,MYCN,SRC,PAK4,MECOM,PARP10,EGR1,G6PD,AXL,CSF1R,NDUFA13,ATIC,BTK,FOS,COL1A1,RRAS2,NTRK3,SBF1,SOX9,MAP3K8,PIN1,DNPH1	76	
Protein Degradation, Protein Synthesis	catabolism	catabolism of protein	1.03E-06	Increased	2.104	 	0.286	CSTA,AXIN1,ELANE,GSAP,CTSG,SH3GLB1,NCSTN,ODC1,RAD23A,PCOLCE,TYSND1,NSF,LGMN,CTSH,P3H1,ANK2,CAV1,DNAJA3,KAT2A,DPH6,APTX,PEX6,ATG7,PCSK5,MAD2L2,CPA3,MMP2,THOP1,JUNB,IER3,RHBDD1,APEH,TAF9B,HSPA8,CTSA,TRPC4AP,CTSB,GAPDH,KIAA0368,CCT3,BACE2,SQSTM1,SFRP1,MME,SORL1,APOE,FYN,ADAM17,CRTAP,DPM2,ADIPOQ,CASP4,SF3B3,SPPL2B,UCHL1,TGM2,TADA3,MTOR,GBA,TIPARP,CST3,SOCS2,NAALAD2,PSMD14,ASPH,HGS,AMFR,PLAT,CTSK,ADRM1,AZIN1,LRSAM1,CSTB,LAMP2,TF,CHFR,TPP1,DVL3,SOX9,PIN1,SOCS3,PFN1,VPS28,HSPA1A/HSPA1B,DPP7,SDC4,HSPA5,GPC3,CCT8,CTSD,TNIP1,CNDP2,CCT5,SIAH2,GSK3B,CAST,NEDD4L,CHMP1A,CPNE1,STXBP1,PSMB5,PCSK7,AURKAIP1,FBXO22,BCL2L1,MMP23B,GIPC1,EDEM1,SNX1,NAGLU,AGAP3,CAPN2,XPNPEP1,RCE1,VHL,UBE2I,RNPEP,TMEM88,UBXN1,ADAMTS7,HOMER2,RNF165,TNFAIP3,MAN1B1,ATF6,FBXO3,VPS4A,SOX17,IPO9,F8,STUB1,CSPG4,FLNA,SMO,LONP1,ATP13A2,CHEK2,AGT,RHBDD3,SRC,C4BPB,MIPEP,C9orf3,SMAD7,PERP,CANX,PLAUR,SCIN,DNAJC1,PSME3,NDUFA13,SERPINE2,FAF1,CAPNS1,TSPAN1,CAT,CPZ,P2RX7,MMP9	159	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	necrosis	necrosis of malignant tumor	1.04E-06	 	-1.810	 	-0.821	EIF3C,BMP4,RAN,SERPINA3,IL6,SPI1,EIF3B,CSE1L,KEAP1,RARA,TXN,HIPK2,MCL1,ETS1,CAPN6,ATG7,NDRG1,TNFRSF10B,MAD2L2,RTN4,CTSB,PSMA4,EBNA1BP2,ITGA1,RPL6,SFRP1,CYR61,PTPRA,NOTCH1,mir-21,ZFP36,DDIT3,FGF2,LEPR,GDF15,ADIPOQ,TNFSF10,SF3B3,DIABLO,TRIB1,MTOR,JUN,CD24,PRKCE,COL18A1,RPS24,MYCN,ACLY,FOS,NR4A2,TF,MCM2,SPRY2,PTGS2,BMP6,PHLDA1,SOCS3,HSPA1A/HSPA1B,CXCL12,MYC,PUF60,GSK3B,CSF3R,CXCL8,MIF,NUP155,PSMB5,HSPA9,POLR2H,VEGFC,PAWR,ERCC2,RPL9,STC1,BCL2L1,PRKCD,IGFBP3,VHL,UBE2I,RUNX1,SFRP2,LEP,BMP2,ABL1,HIF1A,NGF,HMOX1,NFKBIA,KIT,PSMA3,ISCU,SEMA3B,ERBB2,PRNP,BEX2,CD59,VCAM1,SNRPB,CXCR4,LRRK2,RPS21,TNFRSF14,BTK,ENO1,LPAR1,CAT,SPARC,TSC22D1,KDR,MMP9,RPLP0	111	
Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease	ovarian lesion	ovarian lesion	1.04E-06	 	-0.087	 	0.589	PCLO,VAC14,IL6,NPAS2,POR,CCND3,FBL,PTGIS,SLX4,C14orf79,ALCAM,EPHX1,COL15A1,SYNM,DDX3X,DTNA,RABL6,TIPARP,GTF3C1,MECOM,KIAA1549L,CDO1,IGF2R,AFF3,KIF7,SWAP70,TBC1D8,WBP2,LIG1,MICALL2,RGCC,AP1B1,CCT5,TUBA1C,CXCL8,H19,TJP2,ERCC2,TXNRD1,BCL2L1,CRHBP,BAP1,SLC11A1,IGFBP4,FEM1A,ZP3,CLUAP1,COL6A6,PHLDB2,HLA-G,ERBB2,SRC,NLRP3,PLAUR,RRAS2,ANO3,COL11A1,CERCAM,ASPSCR1,CTGF,GMDS,CMTM4,TYRO3,PCDH17,POMC,ACP5,ITGA3,EVI5L,MGAT4B,EFL1,PIK3C2B,CMKLR1,CAPN6,ATP8B4,HBEGF,TMEM267,JUNB,HMGA1,PARP3,CREB5,SH3GL1,DPH2,ACAD11,MS4A14,NCLN,RTN4,NOTCH1,ANG,COL3A1,NRP1,GSTM5,RP9,HEATR1,SIN3B,THBS3,CORO2B,STOM,JUN,KAT2B,PDE3B,ENTPD6,DIP2B,CD24,COL22A1,NPTXR,FUK,PLXNA1,MYOM2,LRSAM1,NBEA,SLIT2,NTM,AXL,DHCR24,PTGS2,ATAD3A,TM4SF1,ZFYVE19,LRFN4,TFF3,FARP1,FAT1,CLEC3B,CLIP3,FAM173A,ALDH1A1,ETS2,COMT,DHTKD1,MCTP1,PGP,GSK3B,HK1,KLHDC3,PAWR,MAPK8IP3,COL6A3,SCRIB,IDO1,SLC4A11,PTPRF,SSU72,THBS1,HSPE1,CFB,GOT2,MAPKAPK2,CHEK2,ADRB2,TMEM104,EPAS1,C9orf3,TANC2,LRRK2,CIART,C2orf88,PLEKHH1,EPHB3,KDR,NIPA2,MAP6,ODC1,FADS3,OGFOD3,EGR2,KEAP1,ARHGAP39,MGP,KANK3,MTHFD2,SPATA18,ALDH3A1,TSHZ2,RNF121,SELE,MFAP5,TNFRSF10B,FLOT1,TFPI2,TMEM127,TNPO2,NRDE2,EVPL,VARS2,GAPDH,ITGA1,IGSF10,APOE,FBXO10,NACC2,FGF2,CUBN,GDF15,CDK4,CTDSPL,IFI27,TGM2,DUSP5,CCL2,GADD45A,CS,SORBS1,DAB2,ADORA1,TBC1D10B,HCAR2,RAD21,MED20,NINL,CUL7,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,ZFPM2,LDLR,TMEM106C,SLC22A18,SEMA3C,ABCC3,ATP13A1,ABCA3,KLF6,PARP2,CES2,STARD7,MYC,TGFBR2,GPX3,GPR4,CXCL14,STAB1,LILRB5,CAST,FMO4,PKP2,GM2A,LAMA2,TLN2,ABCA8,DUSP1,GIPC1,APCDD1,ALDH1A2,IGFBP3,DNAJB6,MEGF8,ESR1,LRRC47,S100P,RUNX1,MAST2,ERAP2,FAM107A,TPR,ZSWIM3,CCL3,GCDH,RAP1GDS1,MSRB3,POLR1C,TIMP1,MCAM,LOC102724428/SIK1,ENPP2,LRPPRC,MCRS1,VARS,PSAT1,NUSAP1,VCAM1,TUBG1,EMD,GATSL3,LARP6,ATIC,CXCL16,PMP22,VAV3,LPAR5,ALKBH3,APOB,CDKN2C,RAPH1,GTF2IRD1,HOXA9,ABR,CSTF2,IRS2,EYA2,RRBP1,TUBB2A,MMP2,TNK2,RAD51D,RAE1,CDH2,MS4A4A,MS4A7,TRO,SPINT2,LRP8,ZER1,CYR61,MYEOV,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,ADAM17,CHCHD6,WASF3,TTC1,KHDC1,DCLK1,VCAN,COL5A1,EFNB2,MTOR,CMTM8,TBCD,TPO,COL18A1,PTPRT,CYP11A1,GSTM1,VPS18,ANGPT1,MGMT,MVB12A,CYP1B1,TF,PLEKHG6,CDK20,MS4A2,PEA15,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,TPM1,ARG2,TUBB,KPNA2,MYO10,PDK4,CSF3R,AXIN2,MIF,SPP1,LMNA,MYOF,STC1,SRSF3,PPP2R1A,ERCC1,PKD1,THSD7B,AKR1B1,RNPEP,COL7A1,ADAMTS7,LEP,EPB41L3,FLRT2,CUTA,PKM,ABL1,TET1,SMPD1,CDKN2B,FAM110B,EPHB6,COL1A2,EVC,PCK2,CSPG4,FUBP3,HIST2H2AC,KIT,NEK7,RNF144B,STK40,CUL9,PRRT3,PI4KB,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,CXCR4,CSF1R,ENO1,ITPA,UBA1,RTN3,MMP9,ATP6V1B2,SHMT2	401	
Cellular Movement	cell movement	cell movement of hepatoma cell lines	1.05E-06	 	0.510	 	-0.241	FYN,SOCS3,NME1,ADAM17,CTGF,LEP,FGF2,KLF6,ADIPOQ,CXCL12,ASNS,VCAN,HDGF,HMOX1,CTSH,CMTM8,STARD13,CAV1,STIM1,LYVE1,CXCL8,VCAM1,SPP1,GNAI1,PLAUR,LMCD1,KRT8,PRKCD,IGFBP3,ITGA1,ELK1,NOTCH1,mir-21	33	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	fatty acid metabolism	1.09E-06	 	1.974	bias	-1.046	APOB,HACD1,HRAS,IL6,POR,SGPL1,ITGA3,LPIN1,ABCC1,SPTLC2,CAV1,LSS,TXN,VPS4B,CERS6,PTGIS,DBP,SEC13,MSMO1,PLAA,S1PR3,HSPA8,LARGE1,AQP9,RTN4,ME2,SLC27A1,ACACA,TRIAP1,PLTP,AKR1C4,HACD3,EPHX1,FYN,APOE,SCAP,LEPR,FGF2,GDF15,SLC1A3,ADIPOQ,TNFSF10,CRAT,TECR,ABCA5,MTOR,CES1,GBA,CS,CCL2,PLIN2,ACSL4,LIPG,LBP,HCAR2,ALDH5A1,CD209,SLC25A13,C5AR1,EGR1,SLC25A1,SLCO2A1,TRIB3,RELN,ACLY,CYP1B1,PLA2G2A,MYO5A,GPAM,PLA2G4A,LDLR,FAM213B,S100A9,LYN,FCER1G,S1PR1,MAP3K8,PTGS2,ABCC3,BMP6,CYP2C8,SOCS3,ADRBK1,AKR1C3,CD36,CD4,SPHK2,PLA2G15,CXCL12,FCER1A,LIPE,PCCB,ABCG1,MYC,CEL,PTGES2,PLA2G5,FAR2,MID1IP1,GPC1,PRELID3A,NSMAF,PDK4,CXCL8,MIF,ACSL3,TJP2,GM2A,GLYAT,PTGDS,ARSA,STX1A,ORMDL3,ELOVL6,BCL2L1,ABCA8,PRKCD,SLC22A5,RGN,CD14,ACOT4,SLC25A10,AKR1B1,TEF,RBP4,LEP,BMP2,MECR,PKM,SMPD1,ELOVL3,ME1,NGF,ACOT7,GCDH,IRAK1,HMOX1,AEBP1,SUCLA2,NFKBIA,EDN1,SAA1,DECR2,KIT,S100A8,ERBB2,GOT2,HMGCL,PRNP,AGT,FAAH,CYP27A1,PCOLCE2,NQO1,SNTB1,CANX,IL18RAP,ACADVL,APOC1,ACAT1,EDNRA,P2RX7	162	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	juvenile rheumatoid arthritis	juvenile rheumatoid arthritis	1.09E-06	 	 	 	 	ADM,MME,SORL1,APOE,SCAP,GADD45B,ZFP36,HSPA1A/HSPA1B,TNFAIP3,TPGS2,IL6,SIL1,CCL3,HLA-G,NR4A3,HLA-DRB1,NFKBIA,CCL3L1,THBS1,S100A8,TXN,PRNP,MCL1,CCR1,MIF,HNMT,CD69,PLAUR,MMP2,ACLY,POLD1,FOSB,GSR,FOS,F11R,HP,NR4A2,S100A9,CD86,PTGS2,ANG	41	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of granulocytes	1.09E-06	 	-1.088	 	-2.910	RARRES2,CAMK1,HSPA1A/HSPA1B,ELANE,CTSG,IL6,CAV1,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SELE,SPP1,ATG7,COCH,FLOT1,MMP2,ORMDL3,TPSAB1/TPSB2,CARD9,ITGAM,PIP5K1C,RTN4,CD14,MAP2K3,MAPK7,SFRP1,MDK,APOE,ADAM17,LEP,GDF15,IRF3,CCL3,GLRX,LYZ,EDN1,CCL2,CCL3L3,THBS1,S100A8,FCGR3A/FCGR3B,AGT,FCER2,CCR1,VCAM1,NLRP3,C5AR1,MMP28,CD69,ST3GAL6,SLIT2,CYP1B1,RCAN1,LY96,SWAP70,VAV3,CAT,LSP1,LYN,S1PR1,MAP3K8,CXCL2,ST3GAL4,MMP9	66	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease	gonadal tumor	gonadal tumor	1.10E-06	 	0.155	 	0.921	PCLO,VAC14,IL6,NPAS2,POR,CCND3,AMHR2,FBL,PTGIS,SLX4,C14orf79,ALCAM,EPHX1,COL15A1,SYNM,DDX3X,DTNA,RABL6,TIPARP,GTF3C1,MECOM,KIAA1549L,SLC25A1,CDO1,IGF2R,AFF3,KIF7,SWAP70,TBC1D8,WBP2,LIG1,MICALL2,RGCC,AP1B1,CCT5,TUBA1C,CXCL8,H19,TJP2,ERCC2,TXNRD1,BCL2L1,CRHBP,BAP1,SLC11A1,IGFBP4,FEM1A,CLUAP1,COL6A6,PHLDB2,HLA-G,ERBB2,SRC,NLRP3,PLAUR,RRAS2,ANO3,COL11A1,CERCAM,PRUNE2,EIF3C,ASPSCR1,CTGF,GMDS,CMTM4,TYRO3,PCDH17,POMC,ACP5,EVI5L,ITGA3,MGAT4B,EFL1,PIK3C2B,CMKLR1,CAPN6,ATP8B4,HBEGF,TMEM267,JUNB,HMGA1,PARP3,CREB5,SH3GL1,MS4A14,DPH2,ACAD11,NCLN,RTN4,NOTCH1,ANG,COL3A1,NRP1,RP9,GSTM5,HEATR1,SIN3B,THBS3,CORO2B,EIF4EBP1,STOM,JUN,KAT2B,PDE3B,ENTPD6,DIP2B,CD24,COL22A1,NPTXR,FUK,PLXNA1,BLMH,MYOM2,LRSAM1,NBEA,SLIT2,NTM,AXL,DHCR24,PTGS2,ATAD3A,TM4SF1,ZFYVE19,LRFN4,TFF3,FARP1,FAT1,CLIP3,CLEC3B,FAM173A,ALDH1A1,ETS2,COMT,DHTKD1,MCTP1,PGP,GSK3B,HK1,KLHDC3,PAWR,MAPK8IP3,COL6A3,SCRIB,IDO1,SLC4A11,PTPRF,SSU72,THBS1,HSPE1,CFB,GOT2,MAPKAPK2,CHEK2,ADRB2,TMEM104,EPAS1,C9orf3,LRRK2,TANC2,CIART,C2orf88,PLEKHH1,EPHB3,KDR,NIPA2,MAP6,ODC1,FADS3,OGFOD3,EGR2,GPRC5C,KEAP1,ARHGAP39,MGP,KANK3,MTHFD2,SPATA18,ALDH3A1,TSHZ2,RNF121,SELE,MFAP5,TNFRSF10B,FLOT1,TFPI2,TMEM127,TNPO2,NRDE2,EVPL,VARS2,GAPDH,ITGA1,IGSF10,APOE,FBXO10,NACC2,FGF2,CUBN,GDF15,CDK4,CTDSPL,HS3ST3A1,IFI27,TGM2,RNF181,DUSP5,CCL2,GADD45A,CS,SORBS1,DAB2,ADORA1,TBC1D10B,HCAR2,RAD21,MED20,NINL,CUL7,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,ZFPM2,LDLR,TMEM106C,SLC22A18,SEMA3C,ABCC3,ATP13A1,ABCA3,KLF6,PARP2,CES2,STARD7,MYC,TGFBR2,GPX3,GPR4,CXCL14,STAB1,LILRB5,CAST,PDZRN3,FMO4,PKP2,GM2A,LAMA2,TLN2,ABCA8,DUSP1,GIPC1,APCDD1,ALDH1A2,IGFBP3,DNAJB6,MEGF8,ESR1,LRRC47,S100P,RUNX1,MAST2,ERAP2,FAM107A,TPR,ZSWIM3,CCL3,GCDH,RAP1GDS1,MSRB3,POLR1C,TIMP1,MCAM,LOC102724428/SIK1,ENPP2,LRPPRC,MCRS1,VARS,PSAT1,NUSAP1,VCAM1,TUBG1,UPP1,EMD,GATSL3,LARP6,ATIC,CXCL16,PMP22,VAV3,LPAR5,ALKBH3,APOB,CDKN2C,HRAS,RAPH1,GTF2IRD1,HOXA9,ABR,ZHX2,CSTF2,IRS2,EYA2,RRBP1,TUBB2A,MMP2,TNK2,RAD51D,RAE1,CDH2,CCND2,MS4A4A,MS4A7,TRO,SPINT2,LRP8,ZER1,CYR61,MYEOV,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,ADAM17,CHCHD6,WASF3,KAZN,TTC1,KHDC1,DCLK1,VCAN,COL5A1,EFNB2,MTOR,CMTM8,TBCD,TPO,COL18A1,PTPRT,CYP11A1,GSTM1,VPS18,ANGPT1,MGMT,MVB12A,CYP1B1,TF,PLEKHG6,CDK20,MS4A2,PEA15,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,TPM1,ARG2,TUBB,KPNA2,MYO10,PDK4,CSF3R,AXIN2,MIF,SPP1,LMNA,MYOF,STC1,SRSF3,PPP2R1A,ERCC1,PKD1,THSD7B,AKR1B1,RNPEP,COL7A1,ADAMTS7,LEP,EPB41L3,FLRT2,CUTA,PKM,ABL1,TET1,CDKN2B,FAM110B,EPHB6,COL1A2,EVC,PCK2,CSPG4,FUBP3,KIT,HIST2H2AC,NEK7,RNF144B,STK40,CUL9,PRRT3,PI4KB,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,CXCR4,CSF1R,ENO1,ITPA,UBA1,RTN3,MMP9,ATP6V1B2,SHMT2	414	
Cardiovascular System Development and Function, Lymphoid Tissue Structure and Development	morphology	morphology of vessel component	1.10E-06	 	 	 	 	PTGIS,ELN,APOE,LOX,CALCRL,CXCR4,CXCL12,MMP2,SGCB,PLOD1,COL1A1,SHC1,GPR4,CST3,VAV3,MKL2,MGP,MAPK7,TMBIM1,EFEMP2,KLF2,COL3A1,FBN2	23	
Cancer, Organismal Injury and Abnormalities	fibromatosis	fibromatosis	1.11E-06	 	 	 	 	COL4A5,ABL1,RBBP8,HRAS,COL8A1,COL15A1,COL1A2,COL5A1,POR,COL16A1,COL6A1,TSC2,SOS1,KIT,COL22A1,RET,COL18A1,COL5A2,COL6A2,COL12A1,EGR1,IFNAR2,CSF1R,COL1A1,COL5A3,CCND2,COL6A3,COL11A1,PTGS2,KDR,ESR1,ATP6V1B2,COL3A1,COL7A1,NRP1	35	
Cell Morphology, Cellular Assembly and Organization	outgrowth	outgrowth of plasma membrane projections	1.13E-06	Increased	2.574	bias	-0.001	BMP4,CAMK1,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,DNAJA3,TXN,TESK1,MATK,RND2,RIMS3,PRAG1,CHN1,GRK5,TNK2,NINJ1,DOCK1,DVL2,SRGAP3,CDH2,RTN4,ITGA1,MAPK7,PTPRA,NRP1,SPTBN1,APOE,ADAM17,PLXNA3,BTG3,FGF2,VTI1B,VCAN,TGM2,EFNB2,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,GFRA2,SLIT2,RELN,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,BRSK1,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,NGF,PTPRF,TNFRSF12A,SHC1,ARHGAP17,MARCH8,THBS1,TIMP1,KIT,ENPP2,NSMF,PRNP,SRC,PAK4,EPN1,VCAM1,SLC12A2,RTKN,LRRK2,SERPINE2,FAIM,KIF2A,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,TNFRSF19,MMP9	115	
Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Duchenne muscular dystrophy	Duchenne muscular dystrophy	1.13E-06	 	 	 	 	LOX,TGFBR3,HIF1A,TAX1BP3,TGFBR2,COL1A2,COL5A1,HLA-DRB1,PLS3,COL6A1,CXCL14,DAB2,TBCD,CAST,MYL3,ADRA1B,PDK4,ADRB2,EMILIN1,COL5A2,COL6A2,TUBB2A,ACLY,CYB561,COL1A1,COLEC12,SDCBP,HLA-DRB4,COL6A3,SERPINH1,S1PR1,CELF2,BNIP3L,SPARC,RSU1,TMOD1,mir-21,ADRA1A,COL3A1	39	
Carbohydrate Metabolism	synthesis	synthesis of polysaccharide	1.14E-06	 	-1.607	 	-2.803	NNAT,SOCS3,GFPT1,CTGF,ADRBK1,CD36,HRAS,IL6,PPP1R3F,GYS1,CCND3,IRS2,GSK3B,GPC1,ADRA1B,SPP1,APLNR,H6PD,VEGFC,THBD,NR1D1,BSG,IGFBP3,SFRP1,B3GAT3,APOE,B3GALT6,LEP,FGF2,LEPR,PPP1R3C,CHPF,BMP2,HS2ST1,ADIPOQ,PPP1CB,HEXA,INPPL1,B4GALT7,MTOR,EDN1,SORBS1,ERBB2,ACADM,PTGER4,AGT,ABHD5,ANGPT1,HYAL1,CSF1R,GPAM,XYLT2,ZFPM2,NTRK3,GBE1,NDST2	56	
Cellular Function and Maintenance	endocytosis	endocytosis by tumor cell lines	1.14E-06	Increased	2.399	bias	0.075	APOE,CD209,AP2M1,ATP6V1D,SHARPIN,CD36,CXCL12,TNFSF10,HBEGF,RPS21,LRRC29,AXL,ATP6AP1,SF3B3,HAX1,ASB1,NKAP,ATP6V1E1,SRSF3,ASGR1,ATP6V1F,CAV1,NAA60,DAB2,ERBB2,EPB41L2,ATP6V1B2	27	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of neutrophils	1.15E-06	 	-0.784	 	-2.539	RARRES2,CAMK1,HSPA1A/HSPA1B,CTSG,ELANE,IL6,CAV1,RASGRP2,FERMT3,PTX3,CXCL8,MIF,SELE,SPP1,ATG7,COCH,FLOT1,MMP2,ITGAM,PIP5K1C,RTN4,CD14,MAP2K3,MDK,SFRP1,MAPK7,APOE,ADAM17,LEP,IRF3,CCL3,GLRX,LYZ,EDN1,CCL2,CCL3L3,S100A8,FCGR3A/FCGR3B,AGT,CCR1,NLRP3,C5AR1,MMP28,CD69,ST3GAL6,SLIT2,CYP1B1,RCAN1,LY96,VAV3,LSP1,CAT,LYN,S1PR1,MAP3K8,CXCL2,ST3GAL4,MMP9	58	
Cellular Movement	cell movement	cell movement of breast cancer cell lines	1.16E-06	 	-0.147	 	-1.959	CTGF,PTPN23,TGFBR3,SPHK2,CXCL12,HRAS,IL6,SDC4,MYC,ADGRF5,MTUS1,CSE1L,CAV1,DNAJA3,KPNA2,TUBA1C,MATK,ETS1,CXCL8,SPP1,ATF3,NDRG1,GSDMB,MMP2,TNK2,ROR1,FOXC1,KLF4,FOSB,CDH2,SDCBP,RAP1GAP,GIPC1,PRKCD,IGFBP3,CAPN2,RSU1,DNAJB6,ESR1,mir-21,UBE2I,NRP1,TNFAIP8,NME1,LEP,FGF2,OSGIN1,BMP2,GNA11,RUVBL1,HIF1A,ENAH,GRINA,TGM2,ID1,SHC1,RAB5A,MTOR,NFKBIA,JUN,CCL2,NET1,TIMP1,FLNA,MCAM,ACSL4,ERBB2,ADRB2,NDUFAF3,S100A1,PLXNA1,SRC,BHLHE41,CXCR4,PLAUR,AXL,FOS,FAF1,KRT8,LPAR1,VAV3,WBP2,SPARC,BMP6,MAP4K4,MMP9	86	
Cardiovascular Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	myocardial infarction	myocardial infarction	1.22E-06	 	-0.435	 	0.087	HCAR3,KCNJ2,CD36,CXCL12,IL6,CD163,NNMT,PADI4,CYBA,PLA2G5,TSC2,TUBA1C,GCLM,GSK3B,ADRA1B,ACTA1,PTX3,CSF3R,MYDGF,GUCY1A3,TUBB2A,THRA,THBD,NOL3,ITGAM,ADRA2A,VKORC1,NCF2,CD14,LRP8,ESR1,COL3A1,APOE,KCNK3,FGF2,GDF15,ADIPOQ,QPRT,HIF1A,NGF,TGM2,HMOX1,CD55,EDN1,CCL3L3,PRKCE,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ADRB2,PLAT,AGT,GSTM1,RNLS,ATP2C1,CXCR4,TUBG1,F13A1,CSF1R,GABRE,LDLR,FCER1G,PTGS2,C6,MMP9,ADRA1A,CYP2C8	68	
Cancer, Organismal Injury and Abnormalities	angiogenesis	angiogenesis of tumor	1.24E-06	 	1.350	 	0.566	ADAM17,FGF2,KLF6,PKM,SEMA6A,CXCL12,HRAS,HIF1A,MYC,TGFBR2,ANGPTL4,TIMP1,THBS1,CST3,FLNA,VEGFD,GPC1,LTBR,COL18A1,AGT,SPP1,NDRG1,ADAMTS1,VEGFC,MMP2,THBD,ADGRG1,ITGAM,CDH5,VAV3,CTSB,ITGA1,PTGS2,CYR61,KDR,ALKBH3,P2RX7,MMP9,mir-21,NRP1	40	
Embryonic Development, Organismal Development	development	development of abdomen	1.32E-06	 	1.944	bias	-0.090	CTGF,BMP4,TGFBR3,RRM2B,HRAS,MST1,POMC,IL6,SPI1,APRT,HOXA9,ODC1,SGPL1,CCND3,RARA,MGP,CAV1,IRS2,AMHR2,SELE,ATG7,STK36,PCSK5,FANCG,HBEGF,MMP2,PYGO2,CCND2,CDH5,EPB42,CD86,ITGA1,MAPK7,SFRP1,NOTCH1,ADM,SPTBN1,APOE,ADAM17,COL4A5,LEPR,FGF2,CFC1/CFC1B,GDF15,ADIPOQ,MTOR,JUN,TIPARP,ALDH1A3,CST3,PDE3B,STARD13,SLC19A1,LY6E,LBP,PLAT,CYP11A1,MYCN,ADRM1,SPRY1,ANGPT1,EGR1,ZNF521,SLIT2,IGF2R,YBX2,FOS,HP,KRT8,TF,BMF,GPBAR1,SPRY2,FKBP4,NR5A2,SOX9,NLE1,PTGS2,BMP6,ID4,LIG1,SOCS3,KLF6,LHCGR,TAF10,GPC3,MYC,TGFBR2,ALDH1A1,PLCE1,ITGA11,OSR1,CXCL14,LTBR,RET,FST,ATF3,ADAMTS1,VEGFC,THRA,DCHS1,FOXC1,PKN1,INHBB,BCL2L1,PKD1,ALDH1A2,CD14,MDK,AKR1B1,ESR1,VHL,RBP4,RUNX1,SULF1,LEP,ZP3,ERN1,BMP2,PKM,ABL1,EMX2,HIF1A,NGF,CDKN2B,HNRNPK,PDCD4,PRKCSH,HDGF,CIAPIN1,SOX17,AEBP1,TIMP1,THBS1,FLNA,SMO,MKL2,KIT,SULF2,ACADM,AGT,RHBDD3,GJA4,SLC20A1,SRC,VCAM1,EPAS1,AQP11,LRRK2,CSF1R,XYLT2,RRAS2,CAT,EDNRA,TSC22D1,KDR,CPEB1,MPV17,MMP9	159	
Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development	outgrowth	outgrowth of neurites	1.32E-06	Increased	2.784	bias	0.216	BMP4,CAMK1,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,DNAJA3,TXN,TESK1,MATK,RND2,RIMS3,PRAG1,CHN1,GRK5,TNK2,NINJ1,DOCK1,DVL2,SRGAP3,CDH2,RTN4,ITGA1,MAPK7,PTPRA,NRP1,SPTBN1,APOE,ADAM17,PLXNA3,BTG3,FGF2,VTI1B,VCAN,TGM2,EFNB2,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,GFRA2,SLIT2,RELN,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,BRSK1,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,NGF,PTPRF,TNFRSF12A,SHC1,ARHGAP17,MARCH8,THBS1,KIT,ENPP2,NSMF,PRNP,SRC,PAK4,EPN1,VCAM1,SLC12A2,RTKN,LRRK2,SERPINE2,FAIM,KIF2A,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,TNFRSF19,MMP9	114	
Cell Death and Survival	cell death	cell death of neuroblastoma cell lines	1.35E-06	 	0.600	 	0.738	NNAT,ITSN1,MBP,RTN1,HSPA1A/HSPA1B,SERPINA3,IL6,HSPA5,CCT8,CCT5,CAST,TXN,GSK3B,GPC1,RET,MCL1,SPP1,ATG7,TNFRSF10B,HSPA9,HMGA1,HSPA8,BCL2L1,IGFBP3,GAPDH,CCT3,CAPN2,MAP2K3,SQSTM1,ANG,ADM,PEBP1,APOE,LEP,DDIT3,FGF2,ABL1,FKBP1A,TNFSF10,CASP4,NGF,GLRX,DIABLO,TGM2,SHC1,NFKBIA,JUN,STUB1,PRKCE,HCST,CUL9,ATP13A2,PRNP,SRC,MYCN,ENO1,RCAN1,CAT,MAOA	59	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of fibrils	1.39E-06	 	 	 	 	LOX,COL5A2,DPT,LTBP2,SFRP2,MFAP5,FKBP1A,MFAP4,FOXC1,CYP1B1,COL1A2,COL5A1,B4GALT7,COL1A1,MKX,CST3,SERPINH1,P3H1,COL11A1,PLOD3,COL3A1	21	
Metabolic Disease	metabolism	abnormal metabolism	1.45E-06	 	 	 	 	LIPE,POMC,TYMP,SLC35C1,GPC3,IDUA,NMUR2,GDE1,SLC16A2,TMBIM1,TNFRSF21,SURF1,CPA3,H6PD,THRA,PANK1,MAP3K12,IGFBP3,RGN,ADIPOR2,ESR1,LOX,IGFBP4,APOE,SFRP2,ERN1,PPP1R3C,NQO2,HIF1A,RAMP2,ALDH2,GBA,CST3,CSPG4,POMGNT2,ALDH5A1,ADRB2,RNLS,GLRX2,NQO1,UPP1,POMGNT1,PLA2G4A,LDLR,ACADVL,SLC25A19,ADCY1,PTGS2,TNFRSF19,MMP9	50	
Cardiovascular System Development and Function	function	function of cardiovascular system	1.51E-06	 	-0.928	 	-2.668	APOB,IL6,ATP2A2,IDUA,CAV1,HEY2,CASQ2,TNFRSF21,ARHGEF4,ANO6,HBEGF,MMP2,IER3,THBD,TIMP4,AQP9,MAPK7,NOTCH1,ADM,SORL1,APOE,ZFP36,FGF2,GDF15,ADIPOQ,FKBP1A,COL15A1,TGM2,ID1,LIPG,ASPH,ADORA1,ABCC9,CYP51A1,LIG3,PLAT,S100A1,SIGMAR1,LAMP2,ZFPM2,LDLR,CLDN5,CBS/CBSL,LIMS1,ATP1A2,DBNL,ST3GAL4,SGCD,MAOA,ABCB6,ADGRA2,ADRBK1,PFKFB1,CD36,CXCL12,GPX3,PLCE1,CAMK2D,PLA2G5,NUPR1,GSK3B,NEDD4L,BIRC3,ADRA1B,RASGRP2,EIF2AK1,KCNJ8,ELN,NOX4,SPP1,APLNR,SGCG,LMNA,THRA,BCL2L1,NOL3,MAP2K5,LEP,PPP1R1A,TNFAIP3,NGF,RAMP2,HMOX1,SHC1,CD55,EDN1,FLNA,TIMP1,KIT,AGT,ADRB2,CD59,RNLS,EPAS1,P2RX4,MTMR14,SMAD7,VSIG4,BTK,ENO1,VAV3,DNM1L,EFEMP2,MMP9	104	
Cell Death and Survival	necrosis	necrosis of prostate cancer cell lines	1.54E-06	 	0.035	 	0.101	SOCS3,HSPA1A/HSPA1B,SPHK2,KLF6,HRAS,SH3GLB1,TYMP,IL6,HSPA5,MYC,ETS2,CAV1,SIAH2,TXN,GSK3B,BIRC3,MCL1,NOX4,FST,NDRG1,TNFRSF10B,VEGFC,HBEGF,PAWR,BCL2L1,PRKCD,IGFBP3,ALCAM,ACACA,MAP2K3,mir-21,AKAP12,PEBP1,MME,IGFBP4,DDIT3,BMP2,GDF15,ABL1,TNFSF10,HIF1A,NGF,SF3B3,DIABLO,ID1,NFKBIA,JUN,EDN1,CCL2,GADD45A,STUB1,DKK3,PRKCE,HCST,SRC,PAK4,EGR1,SMAD7,PLAUR,DEFB1,FOS,CAT,PTGS2	63	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease	neoplasia	Ovarian Cancer and Tumors	1.55E-06	 	-0.358	 	0.291	PCLO,VAC14,IL6,NPAS2,POR,CCND3,FBL,PTGIS,SLX4,C14orf79,ALCAM,EPHX1,COL15A1,SYNM,DDX3X,DTNA,RABL6,TIPARP,GTF3C1,MECOM,KIAA1549L,CDO1,IGF2R,AFF3,KIF7,SWAP70,TBC1D8,WBP2,LIG1,MICALL2,RGCC,AP1B1,CCT5,TUBA1C,CXCL8,H19,TJP2,ERCC2,TXNRD1,BCL2L1,CRHBP,BAP1,SLC11A1,IGFBP4,FEM1A,CLUAP1,COL6A6,PHLDB2,HLA-G,ERBB2,SRC,NLRP3,PLAUR,RRAS2,ANO3,COL11A1,CERCAM,ASPSCR1,CTGF,GMDS,CMTM4,TYRO3,PCDH17,POMC,ACP5,ITGA3,EVI5L,MGAT4B,EFL1,PIK3C2B,CMKLR1,CAPN6,ATP8B4,HBEGF,TMEM267,JUNB,HMGA1,PARP3,CREB5,SH3GL1,DPH2,ACAD11,MS4A14,NCLN,RTN4,NOTCH1,ANG,COL3A1,NRP1,GSTM5,RP9,HEATR1,SIN3B,THBS3,CORO2B,STOM,JUN,KAT2B,PDE3B,ENTPD6,DIP2B,CD24,COL22A1,NPTXR,FUK,PLXNA1,MYOM2,LRSAM1,NBEA,SLIT2,NTM,AXL,DHCR24,PTGS2,ATAD3A,TM4SF1,ZFYVE19,LRFN4,TFF3,FARP1,FAT1,CLEC3B,CLIP3,FAM173A,ALDH1A1,ETS2,COMT,DHTKD1,MCTP1,PGP,GSK3B,HK1,KLHDC3,PAWR,MAPK8IP3,COL6A3,SCRIB,IDO1,SLC4A11,PTPRF,SSU72,THBS1,HSPE1,CFB,GOT2,MAPKAPK2,CHEK2,ADRB2,TMEM104,EPAS1,C9orf3,TANC2,LRRK2,CIART,C2orf88,PLEKHH1,EPHB3,KDR,NIPA2,MAP6,ODC1,FADS3,OGFOD3,EGR2,KEAP1,ARHGAP39,MGP,KANK3,MTHFD2,SPATA18,ALDH3A1,TSHZ2,RNF121,SELE,MFAP5,TNFRSF10B,FLOT1,TFPI2,TMEM127,TNPO2,NRDE2,EVPL,VARS2,GAPDH,ITGA1,IGSF10,APOE,FBXO10,NACC2,FGF2,CUBN,GDF15,CDK4,CTDSPL,IFI27,TGM2,DUSP5,CCL2,GADD45A,CS,SORBS1,DAB2,ADORA1,TBC1D10B,HCAR2,RAD21,MED20,NINL,CUL7,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,ZFPM2,LDLR,TMEM106C,SLC22A18,SEMA3C,ABCC3,ATP13A1,ABCA3,KLF6,PARP2,CES2,STARD7,MYC,TGFBR2,GPX3,GPR4,CXCL14,STAB1,LILRB5,CAST,FMO4,PKP2,GM2A,LAMA2,TLN2,ABCA8,DUSP1,GIPC1,APCDD1,ALDH1A2,IGFBP3,DNAJB6,MEGF8,ESR1,LRRC47,S100P,RUNX1,MAST2,ERAP2,FAM107A,TPR,ZSWIM3,CCL3,GCDH,RAP1GDS1,MSRB3,POLR1C,TIMP1,MCAM,LOC102724428/SIK1,ENPP2,LRPPRC,MCRS1,VARS,PSAT1,NUSAP1,VCAM1,TUBG1,EMD,GATSL3,LARP6,ATIC,CXCL16,PMP22,VAV3,LPAR5,ALKBH3,APOB,CDKN2C,RAPH1,GTF2IRD1,HOXA9,ABR,CSTF2,IRS2,EYA2,RRBP1,TUBB2A,MMP2,TNK2,RAD51D,RAE1,CDH2,MS4A4A,MS4A7,TRO,SPINT2,LRP8,ZER1,CYR61,MYEOV,SPTBN1,HIST1H1C,HIST2H2AA3/HIST2H2AA4,ADAM17,CHCHD6,WASF3,TTC1,KHDC1,DCLK1,VCAN,COL5A1,EFNB2,MTOR,CMTM8,TBCD,TPO,COL18A1,PTPRT,CYP11A1,GSTM1,VPS18,ANGPT1,MGMT,MVB12A,CYP1B1,TF,PLEKHG6,CDK20,MS4A2,PEA15,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,TPM1,ARG2,TUBB,KPNA2,MYO10,PDK4,CSF3R,AXIN2,MIF,SPP1,LMNA,MYOF,STC1,SRSF3,PPP2R1A,ERCC1,PKD1,THSD7B,AKR1B1,RNPEP,COL7A1,ADAMTS7,LEP,EPB41L3,FLRT2,CUTA,PKM,ABL1,TET1,CDKN2B,FAM110B,EPHB6,COL1A2,EVC,PCK2,CSPG4,FUBP3,HIST2H2AC,KIT,NEK7,RNF144B,STK40,CUL9,PRRT3,PI4KB,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,CXCR4,CSF1R,ENO1,ITPA,UBA1,RTN3,MMP9,ATP6V1B2,SHMT2	399	
Infectious Diseases	replication	replication of virus	1.58E-06	Increased	3.396	 	1.356	EIF3C,AHCYL1,SGK1,HRAS,IL6,SGPL1,SP110,ITGA3,CSE1L,SMARCB1,MARCH2,CAV1,ATF4,DMAP1,ATG7,FANCG,GRK5,TNK2,MNDA,NLRX1,IFNAR2,UBQLN4,RAE1,NRBP1,MAP3K12,PIP5K1C,FSCN1,PPP1R15A,APOBEC3C,IL10RA,MAP2K3,mir-21,ATP6V0B,EIF4EBP2,GBP1,DAPK2,CDK4,TNFSF10,FKBP1A,TBL3,DCLK1,ATP6AP1,IFI27,DDX3X,EIF4EBP1,EFNB2,DCLK2,MTOR,JUN,CCL3L1,CCL2,CCL3L3,CST3,ANXA5,SNX10,SOCS2,LY6E,PSMD14,PIK3R2,PCBP2,PI4KA,CCR1,SIGMAR1,CD209,EGR1,MED30,SLIT2,F11R,LAMP2,KRT8,RBM42,S100A9,SPRY2,ATP1A2,POLA2,MAN2B1,PIN1,CH25H,SOCS3,TNFRSF4,ADRBK1,CD4,HAVCR2,RABEP1,CXCL12,TUBB,MYC,TGFBR2,CEL,MAP2K2,GABARAPL1,AMPH,STAB1,MID1IP1,GSK3B,VNN2,BIRC3,TRIM5,ADRA1B,FERMT3,PTX3,CXCL8,SPP1,STK39,PCSK7,POLR2H,AGTRAP,GPR146,BCL2L1,CDC42BPB,PKD1,DUSP1,PRKCD,RARRES3,XPNPEP1,ESR1,KATNB1,MAP2K5,RUNX1,SFTPD,ERN1,BMP2,PTPMT1,ABL1,IRF3,NAA10,NGF,CCL3,EPHB6,HMOX1,NFKBIA,S100A8,SULF2,NCL,LONP1,PRNP,AP2M1,EPAS1,APBB1IP,ATP2C1,CXCR4,EXOSC5,F13A1,TRMT61A,CAT,UBE2E2,MAP4K4,P2RX7,ISG20,ATP6V1B2,MMP9	151	
Connective Tissue Development and Function, Tissue Morphology	mass	mass of adipose tissue	1.59E-06	 	1.603	 	1.007	PLIN1,PTTG1,LIPE,POMC,IL6,PNRC2,G0S2,LPIN1,BCAT2,CAV1,ATF4,IRS2,GSK3B,SLC2A5,RBM38,ATF3,ATG7,SURF1,CIDEC,LMNA,JUNB,NPY5R,FOSB,DUSP1,HIF1AN,IGFBP3,ADIPOR2,ESR1,IGFBP4,APOE,LEP,LEPR,GDF15,ADIPOQ,CEBPD,WDR13,EIF4EBP1,TRIB1,PCK2,PDE3B,CSPG4,DUSP10,PLIN2,ENPP2,ADRB2,AGT,UCP2,C5AR1,ZNF521,HDC,GFRA2,BSCL2,CCDC3,GPAM,LDLR,DHCR24,ATP1A2,APOC1,PTGS2	59	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of lipid	1.60E-06	 	-0.276	 	-0.481	PLIN1,APOB,ACAT2,CD36,CXCL12,LIPE,POMC,IL6,TAF10,ODC1,IDUA,CEL,LPIN1,GLB1,ABCC1,CAV1,MID1IP1,GSK3B,LPIN2,KLF2,HADHA,GULP1,CERS6,PIK3C2B,CXCL8,MIF,ATG7,ACP2,GM2A,CIDEC,THY1,LMNA,ARSA,ECI1,BCL2L1,ERCC1,SLC27A1,ACACA,PLTP,ADIPOR2,VHL,mir-21,APOE,SFTPD,LEP,LEPR,BMP2,HCAR1,PTPMT1,CEBPD,ADIPOQ,HEXA,SMPD1,ATF6,ELOVL3,H2AFZ,GRINA,IDH1,HMOX1,GBA,EDN1,TIMP1,PLIN2,SAA1,RENBP,ENPP2,IFRD1,AGT,CYP11A1,SRC,DHRS3,ABHD5,EPAS1,UCP2,PCOLCE2,IGF2R,PLA2G4A,GPAM,LAMP2,LDLR,SLC2A8,ACADVL,LPAR1,APOC1,LYN,ACAT1,RDH5	87	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	abnormal morphology	abnormal morphology of ventricular wall	1.62E-06	 	 	 	 	ADM,APOE,ADAM17,ADRBK1,ABL1,CDK4,FKBP1A,IL6,MYH11,BIN1,ATP2A2,IDUA,SHC1,JUN,CCND3,THBS1,CAV1,LY6E,ERBB2,HEY2,CASQ2,HEY1,EPN1,VCAM1,DHRS3,PAK4,SGCG,CXCR4,SMAD7,IGF2R,ZFPM2,CCND2,ITPA,CAPN2,TXNRD2,MMP9	36	
Cell Morphology, Cellular Assembly and Organization	morphology	morphology of lysosome	1.62E-06	 	 	 	 	SRC,IDUA,MGRN1,CTSA,LAMP2,ACP2,KIF5B,GAA,NAGLU,TPP1,MAN2B1,ATP13A2,PRNP	13	
Cardiovascular System Development and Function, Organismal Development, Tissue Morphology	vasodilation	vasodilation of aorta	1.63E-06	 	-0.170	 	0.094	ADM,SRC,APOE,MFAP5,PLAUR,HBEGF,S1PR3,EFNB2,ALDH2,MFAP2,LDLR,RGS5,LPAR1,THBS1,ABCC1,MKL2,TMBIM1,EFEMP2,AGT	19	
Nucleic Acid Metabolism	metabolism	metabolism of nucleic acid component or derivative	1.65E-06	 	0.032	 	-1.826	GFPT1,DPYD,BMP4,GMDS,RRM2B,COX8A,HRAS,POMC,IL6,APRT,POR,CAV1,AHCY,MCL1,CTNS,PTGIS,CALCRL,GUCY1A3,SURF1,CTPS1,HSPA8,GAMT,PDE1B,PRPSAP1,AK4,ADM2,ALDOA,RAMP3,ACACA,ADM,AKAP12,APOE,ATP5G1,CHCHD10,FGF2,CHCHD6,NT5C,COASY,SLC31A2,CES1,CS,CCL2,PDE3B,DCXR,HCAR2,TSTA3,SLC25A13,UCP2,IMPDH2,DPAGT1,TK2,ACLY,CYP1B1,GPR183,GPAM,CBS/CBSL,GPBAR1,ADCY1,ATP1A2,FBP1,MAN2B1,PTGS2,MSRA,BMP6,SOCS3,ADSSL1,ATP5D,ADRBK1,HSPA1A/HSPA1B,LHCGR,TYMP,MYC,NNMT,WDR5,AK1,PGD,G0S2,UQCC2,GPR4,COMT,NMNAT2,APLNR,SPP1,FMO2,GLYAT,TALDO1,H6PD,DGUOK,GNAZ,PANK1,GZMH,ADRA2A,PRKCD,SLC22A5,SNX1,ACOT4,AK2,ZNRD1,GMPPB,LEP,PKM,QPRT,SMPD1,NUDT2,HIF1A,ME1,ACOT7,NGF,RAMP2,GCDH,REXO2,SHC1,ALDH2,ADSL,RGS17,HMOX1,SUCLA2,EDN1,THBS1,HMGCL,LONP1,PTGER4,ADRB2,ASIP,PRNP,AGT,RGS20,USMG5,CXCR4,UPP1,NQO1,G6PD,GNAI1,ATIC,ITPA,LPAR1,EDNRA,SPARC,NUCB2,EPB41L2,DNM1L	141	
Cellular Growth and Proliferation	colony formation	colony formation	1.65E-06	 	0.989	 	0.259	ITSN1,TYRO3,HRAS,IL6,EIF6,SPI1,HOXA9,SMARCB1,P3H1,TSC2,LUM,CAV1,DNAJA3,ALDH3A1,ETS1,BIRC7,ATG7,NDRG1,MT1X,MMP2,HMGA1,JUNB,PPP1R15A,CTSB,ITGA1,SFRP1,SQSTM1,CYR61,IFIT2,NOTCH1,mir-21,AKAP12,NME1,ADAM17,RALA,GADD45B,DDIT3,FGF2,ADIPOQ,TNFSF10,RUVBL1,VCAN,EIF4EBP1,DIABLO,ID1,KAT2B,JUN,CCL2,GADD45A,CCL3L3,CSF2RA,SOCS2,TRIT1,SH3GLB2,RASSF5,HCAR2,S100A1,MAPKAP1,MECOM,SPRY1,EGR1,AXL,GRN,FOS,KRT8,LMO3,NTRK3,SPRY2,CHFR,PEA15,BNIP3L,PTGS2,PIN1,ID4,PHLDA1,VPS28,TFG,PTTG1,CD4,HSPA1A/HSPA1B,KLF6,CXCL12,GPC3,BIN1,MYC,CTSD,ALDH1A1,RHOB,NUPR1,KPNA2,C1QBP,RET,TEK,PTX3,CSF3R,MIF,SPP1,ATF3,DOK2,HSPA9,BAMBI,THRA,KLF4,RASD1,SLC3A2,BCL2L1,CCNG2,LIMA1,IGFBP3,MDK,ESR1,VHL,RUNX1,LOX,IGFBP4,LEP,SFRP2,EPB41L3,ABL1,IRF3,HIF1A,NGF,CCL3,PTPRF,ETV6,HDGF,HMOX1,SHC1,NFKBIA,EDN1,MCAM,KIT,ERBB2,SEMA3B,SRC,EPAS1,SMAD7,MKNK2,SERTAD1,CSF1R,ATIC,BTK,ENO1,RCAN1,VAV3,CAT,SPARC,ING1,MMP9	149	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	thyroid cancer	thyroid cancer	1.68E-06	 	 	 	 	PRUNE2,CBX7,SOCS3,TFF3,AXIN1,PTTG1,RTN1,UNC5B,ANKMY1,HRAS,ASCC2,MYC,TGFBR2,POR,ITGA3,NUP93,TSC2,TUBA1C,RET,TEK,ETS1,PEX6,SPP1,ADAMTS1,TUBB2A,CLIP2,LAMC3,THRA,MMP2,CRABP1,FLCN,CORO7/CORO7-PAM16,BCL2L1,CCND2,PKD1,RAP1GAP,LSM7,ZER1,NOTCH1,mir-21,SPTBN1,AMY1C (includes others),FCGRT,SFRP2,FGF2,FLRT1,GDF15,PKM,CDK4,IDH1,EFNB2,AHNAK,TIMP1,THBS1,SRGAP1,DAP3,KIT,PRKCE,ARHGEF2,ERBB2,TPO,TMEM132B,GJA4,MAPKAP1,CXCR4,TUBG1,ARHGAP4,AXL,CSF1R,NDUFA13,CXCL16,CLGN,RBM42,S1PR1,MAP3K8,PTGS2,ELK1,ABCC3,KDR,DSG2,XK,MMP9,FCGBP	83	
Cancer, Cellular Development, Cellular Growth and Proliferation, Neurological Disease, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of glioma cells	1.69E-06	 	1.014	 	0.240	BEX2,CSF3R,SRC,FGF2,GDF15,SPHK2,CDK4,TNFSF10,DIRAS1,GRN,PYGO2,DVL2,S100A9,CSF2RA,PRKCD,SFRP1,NRP1	17	
Cardiovascular Disease	peripheral vascular disease	peripheral vascular disease	1.70E-06	 	-0.626	 	-0.248	HCAR3,APOB,DNAJB4,SGK1,SNTA1,VWA5A,SLC9A1,CAAP1,NPL,EGR2,PLEKHO2,SLCO2B1,UNG,RRBP1,TUBB2A,FAHD2A,THY1,NGRN,CTSA,VKORC1,NPR3,BTG2,CTSB,EBNA1BP2,PLTP,FTH1,HIST2H2AA3/HIST2H2AA4,APOE,ADIPOQ,HSD17B11,HYOU1,ADAP2,CKAP4,PDE3B,CST3,TINAGL1,SNX10,DAB2,HCAR2,FCGR3A/FCGR3B,PLAT,CCR1,UCP2,C5AR1,GABRE,PLA2G4A,LY96,NR4A2,LDLR,S100A9,LYN,TPP1,PTGS2,NEDD9,ADRA1A,KTN1,CD36,CA4,HSPA1A/HSPA1B,CXCL12,CD163,NNMT,GPX3,HSPA4,ETS2,AMPH,TUBA1C,ADRA1B,GULP1,NOX4,SPP1,CAPG,KLF4,RPL9,LMCD1,ADRA2A,CCL18,S100P,RUNX1,PPP1CB,QPRT,HIF1A,IRF3,GLRX,SLC2A3,TNFRSF12A,COL1A2,SUCLA2,HLA-DRB1,COL6A1,EDN1,THBS1,LOC102724428/SIK1,STK24,SEMA3B,PTGER4,ADRB2,PRNP,VCAM1,CXCR4,ATP2C1,TUBG1,PLAUR,VSIG4,F13A1,RUFY1,COL1A1,LPAR1,CYTIP,EDNRA,KDR,MAP4K4,MMP9	113	
Immunological Disease	systemic autoimmune syndrome	systemic autoimmune syndrome	1.77E-06	 	1.119	 	0.894	HCAR3,HLA-DOA,CTSG,CACNA1H,C1QA,CLSTN2,IL6,EEF1G,SKIV2L,IP6K3,EGR2,CCND3,ECHDC1,ETS1,TNFRSF21,CERS6,PTGIS,RBM38,SELE,COMP,TNFRSF10B,FLOT1,IFNAR2,HSPA8,TMEM127,CTSA,HLA-DRB4,VARS2,NCF2,ARHGEF6,CTSB,TFRC,CD86,mir-21,FTH1,APOE,COL4A5,GADD45B,FGF2,CDK4,ADIPOQ,ZBTB9,C1R,CCL2,IL17D,LY6E,FCGR3A/FCGR3B,FCER2,CCR1,UCP2,TJP1,CD69,SPATS2L,TK2,GRN,FOS,HP,NR4A2,CBS/CBSL,LYN,XAF1,MAP3K8,MSRA,SGCD,MT2A,TRAPPC2L,SOCS3,RARRES2,HAVCR2,HSPA1A/HSPA1B,RGCC,ABCG1,GPNMB,TGFBR2,PADI4,CARD8,CXCL14,EEF1E1,CXCL8,CAPG,PPP1R11,SLC3A2,FOSB,BCL2L1,H3F3A/H3F3B,DUSP1,FAM26F,SLC7A2,NAGLU,FZD5,MDK,ESR1,C2,RBP4,ZNRD1,PTGFR,IGFBP4,FRZB,DNASE1L3,ABCF1,TPGS2,CCL3,HLA-G,ALDH2,HLA-DRB1,TIMP1,SAA1,VARS,CD1C,AGT,SRC,VCAM1,PLAUR,HCG9,ATIC,CXCL16,HRSP12,PHF19,CAT,SMG7,CXCL2,MAP4K4,COX15,PRUNE2,MSRB2,BMP4,SGK1,ELANE,HSD17B8,NR4A3,GAA,TXN,EYA2,MCL1,PPIL6,CALCRL,MMP2,C1orf162,AQP9,CD68,IL10RA,MS4A7,ALDOA,GLUL,RAMP3,LRP8,ALAS2,IFIT2,ANG,COL3A1,ADM,MME,SORL1,FCGRT,SQLE,SCAP,ZFP36,TNFSF10,ST6GALNAC4,ATAT1,FKBP1A,GPC4,CASP4,MYH11,ENAH,MTOR,LYZ,CCL3L1,CCL8,CCL3L3,CST3,SOCS2,SLC19A1,CD24,LBP,LPP,FUK,RPS24,STK19,C5AR1,TYROBP,IMPDH2,TRIM28,CINP,BRMS1,ACLY,POLD1,GABRE,PLA2G2A,GBP4,F11R,GLIPR2,S100A9,FCER1G,S1PR1,C6orf48,CELF2,PTGS2,VPS52,RGS1,TNFRSF4,TFG,CD36,CD4,CXCL12,IL17RC,SDC4,TUBB,NRSN2,CAMK2D,G0S2,UQCC2,NMNAT2,RET,ARL16,HLA-F,GCA,WDR46,ACTA1,PHACTR3,CSF3R,MIF,HNMT,SPP1,DNASE2,NUP155,ICA1,CYYR1,LMO4,EGR3,GSR,C1QTNF6,ITGAM,ASIC1,CCL18,COL7A1,ADAMTS7,LEP,PRDX5,SLC7A1,TNFAIP3,UBASH3B,SIL1,NGF,RAMP2,NELFE,PDCD4,EVC,COL1A2,HMOX1,RAB5A,NFKBIA,CCL13,THBS1,DKK3,CFB,S100A8,HCST,IFRD1,ALPL,CHEK2,PTGER4,ADRB2,PRNP,MIPEP,CXCR4,VSIG4,LRRK2,FAF1,ENO1,ITPA,DIP2C,LRP1B,DYM,P2RX7,MMP9	276	
Cardiovascular Disease, Organismal Injury and Abnormalities	acute coronary syndrome	acute coronary syndrome	1.87E-06	 	-0.435	 	0.087	HCAR3,APOB,KCNJ2,CD36,CXCL12,IL6,CD163,PADI4,NNMT,CYBA,PLA2G5,TSC2,TUBA1C,GCLM,GSK3B,ACTA1,ADRA1B,PTX3,CSF3R,GUCY1A3,MYDGF,TUBB2A,THRA,THBD,NOL3,ITGAM,ADRA2A,VKORC1,NCF2,RTN4,CD14,LRP8,ESR1,COL3A1,APOE,LEP,KCNK3,FGF2,GDF15,ADIPOQ,QPRT,HIF1A,NGF,TGM2,HMOX1,CD55,EDN1,CCL3L3,PDE3B,PRKCE,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ADRB2,PLAT,AGT,GSTM1,RNLS,ATP2C1,CXCR4,TUBG1,F13A1,CSF1R,GABRE,PLA2G2A,LDLR,FCER1G,PTGS2,C6,MMP9,ADRA1A,CYP2C8	73	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	abnormal morphology	abnormal morphology of right ventricle	1.88E-06	 	 	 	 	ADAM17,CXCR4,HBEGF,FKBP1A,SLCO2A1,RAMP2,ATP2A2,IGF2R,DOCK1,HMOX1,PLA2G4A,TIMP4,ZFPM2,PLCE1,EDN1,NTRK3,GAA,CAV1,MAPK7,HEY2	20	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of macrophages	1.94E-06	 	1.655	bias	0.150	CNN2,RARRES2,ABL1,ADIPOQ,CXCL12,MST1,MYLK,HIF1A,CCL3,VCAN,RHOB,CCL2,CCL3L3,FLNA,STAB1,MAPKAPK2,PRNP,CXCL8,MIF,SPP1,EPAS1,TYROBP,CXCR4,DEFB1,PTGDS,CSF1R,NINJ1,S1PR1,ITGA1,MDK,PTGS2,KDR	32	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	tumorigenesis	tumorigenesis of genital organ	1.99E-06	 	0.183	 	0.676	PCLO,ASS1,VAC14,PAQR7,TLE1,POR,PPRC1,TSC2,VIT,WASH3P,DDIT4,SLX4,KIAA1147,RANBP3,HLA-DRB4,CDH5,ALCAM,C14orf79,BRE,KIAA1217,mir-21,FHL1,GBP1,ADIPOQ,TUBB2B,SYNM,DIABLO,C1R,RABL6,TIPARP,LY6E,EMP3,ID3,GPR183,AFF3,COG5,KIF7,SWAP70,CBS/CBSL,TBC1D8,GCSH,WBP2,AKR1C3,RGCC,TRPM8,TMEM169,DNAJC15,ANKDD1A,TUBA1C,VNN2,TEK,ADAMTS1,KANK1,BCL2L1,CRHBP,PSME4,BAIAP2L2,SUN1,ETV5,FEM1A,ZNF252P,CLUAP1,KCNS3,F8,NLRP3,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,RRAS2,SPARC,ANO3,FECH,TSC22D1,ING1,MED24,EIF3C,ASPSCR1,GFPT1,CTGF,MSRB2,GMDS,PPP4C,SGPL1,SP110,SLC22A15,PRG4,MCL1,PPIL6,PIK3C2B,DFNA5,ATG7,PLEC,HBEGF,TMEM267,GRK5,HMGA1,PARP3,CREB5,SH3GL1,CCDC136,MS4A14,ACAD11,NCLN,NOTCH1,EOGT,NRP1,ILVBL,COL3A1,SORL1,CPSF2,ABI3BP,RP9,ZFP36,LEPR,NQO2,SIN3B,ST6GALNAC4,FKBP1A,CASP4,MEOX2,ATP6AP1,KLF9,ENTPD6,DIP2B,COL22A1,TXNL1,HGS,AHNAK2,LIMCH1,NPRL2,RPS24,NAP1L4,CD209,SLC25A13,BLMH,EGR1,COL12A1,MED30,DDX24,RELN,NTM,DHCR24,PTGS2,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,CLIP3,CLEC3B,TBX15,LHCGR,SLC35F1,DNAJB2,ZNF91,FAM173A,CNDP2,PLCE1,ETS2,DHTKD1,COMT,MCTP1,NMNAT2,NAV1,PGP,EGR3,USP36,FBXO22,PAWR,ATP10A,ZMYND15,TPSAB1/TPSB2,GPR146,SORD,LRRC41,COL6A3,SCRIB,UVRAG,CDK5RAP2,ICK,NGF,PTPRF,SSU72,GNG11,THBS1,ZNF493,TMEM104,ATP2C1,C9orf3,HYAL1,LRRK2,TANC2,ANO2,NCAPH2,COL1A1,PLEKHH1,PAG1,PLP2,SLIT3,NIPA2,SVEP1,SYTL2,MAP6,CACNA1H,SLC35C1,RNF125,SUSD1,ODC1,RNASE4,OGFOD3,NUP93,CYBA,GPRC5C,EFHB,ARHGAP39,SPATA18,ALDH3A1,TSHZ2,NSUN4,ALDH1B1,DPT,PLD3,SOGA1,MFAP5,TNFRSF10B,RUNDC3B,OSBPL10,RPAP3,PLLP,TNPO2,MN1,ZNF606,SLC16A5,ARHGEF6,GCC1,TFRC,IGSF10,PTPRA,NOL7,APOE,NME1,FBXO10,NACC2,PLXNA3,CUBN,IGSF1,GDF15,CDK4,CTDSPL,TECR,ZNF285,IFI27,RNF181,DUSP5,CCL2,SOS1,DAB2,ADORA1,HCAR2,RAD21,CYP51A1,LIG3,SIGMAR1,HELZ,SPRY1,MED20,STON1,ARHGEF5,ZFPM2,LDLR,ATP6V0A2,BMPER,TP53BP1,BMP6,ST3GAL4,ADRA1A,KTN1,MAOA,BZW2,NOC3L,MEGF9,USP5,ABCA3,PPFIBP2,TIGD2,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GPX3,TPRN,CXCL14,ZNF598,GYPE,STAB1,LILRB5,KIF25,RPAP1,FMO4,GULP1,POLR3C,PKP2,STARD5,VEGFC,DCHS1,TLN2,ABCA8,MATN2,GIPC1,APCDD1,ALDH1A2,SORCS2,THAP7,CCPG1,ESR1,LRRC47,S100P,MAST2,POLR3F,PTGFR,ERAP2,FAM107A,CDC20,FRZB,SRPX,SCARA5,DENND4B,ZSWIM3,DCAF4,SLC15A3,GSTT1,SLC2A3,IRAK1,RAP1GDS1,TRIM6,RGS5,AHNAK,TIMP1,OLFML2A,DNAJC4,MCAM,LOC102724428/SIK1,VARS,GJA4,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,UPP1,PGAP2,ZNF16,N4BP1,PSME3,ATIC,SH3PXD2A,CLGN,PHF19,VAV3,LPAR5,SGK1,MAF,ELANE,CDKN2C,GTF2IRD1,HOXA9,NCOA7,NOSIP,SLC4A3,ABR,ZHX2,CSTF2,ALPK1,GUCY1A3,MMP2,IER3,SCNN1D,RAD51D,RAE1,DOCK1,AQP9,MS4A4A,C11orf80,MAP3K20,MS4A7,ALDOA,TRO,LRP8,HSPB7,SLC35A4,HIST2H2AA3/HIST2H2AA4,ALDH4A1,RALA,UQCRH,CHCHD6,KAZN,KHDC1,VCAN,MTOR,SRGAP1,ANXA5,SOCS2,PRKCE,ACSL4,TBCD,LPP,COL18A1,PLAT,PTK7,DNAH6,CYP11A1,C9orf142,GSTM1,MFAP4,PCDH9,STXBP6,COL5A3,CLDN5,MCM2,PEA15,DBNL,SCAMP3,FZD7,ADRBK1,XXYLT1,FNIP2,ARG2,COBL,KPNA2,LTBR,FAM65B,MYO10,AGBL5,ADRA1B,CSF3R,C8orf46,SPP1,ITPR2,ZNF408,PCSK7,LMNA,MYOF,EIF2S2,RPL9,DPP9,PANK1,GSR,HSPA13,THSD7B,AKR1B1,RNPEP,COL7A1,AOC3,DRAP1,ADAMTS7,LEP,FLRT2,ANTXR1,PNMAL1,RAMP2,ADSL,ZMAT3,FLNA,FUBP3,HIST2H2AC,MICALL1,PSMA3,S100A8,RNF144B,MYO16,PRRT3,RAB11FIP3,TMEM132B,SNAPC4,SPOCD1,DLGAP4,LCLAT1,AP3D1,CPED1,F13A1,MKNK2,CSF1R,ENO1,ITPA,LRP1B,DYM,OLFML2B,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,ATP6V1B2,MMP9,SHMT2,CBX7,RPE,AXIN1,PPP2R3B,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,AMHR2,FBL,PTGIS,SLC2A5,NDUFS7,GFM1,PTPN3,CTSB,FTH1,EPHX1,CD163L1,COL4A5,PSMD7,GNA11,MRPL38,COL15A1,DDX3X,DTNA,ABCC9,GTF3C1,MECOM,KIAA1549L,CD69,SLC25A1,SPATS2L,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,GCNA,MXRA5,LIG1,SOCS3,MICALL2,RABEP1,AP1B1,CEP104,ZNF75D,ARHGAP20,CCT5,ERAL1,ACTG2,KMT5A,CXCL8,STXBP1,TJP2,ARL17A/ARL17B,H19,MAN1C1,MAPK8IP2,BAMBI,H6PD,FIG4,RAB34,ERCC2,TXNRD1,ADRA2A,GPS1,SLC7A2,BAP1,CCDC80,TNS1,GSDMC,SYN1,SLC11A1,VHL,SULF1,IGFBP4,LITAF,PC,PLGRKT,HABP4,COL6A6,PHLDB2,HLA-G,DHCR7,ESPNL,EDN1,GTPBP2,FARS2,ERBB2,THBS4,SRC,PKP1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,CERCAM,PRUNE2,KCND2,CMTM4,TYRO3,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,NR4A3,EVI5L,ITGA3,LGMN,IRX3,KIF21A,MGAT4B,AFAP1,FAM127A,CAPN5,EFL1,SFRP4,CMKLR1,CAPN6,ZC3HC1,ATP8B4,CEP89,JUNB,MNDA,BCAP29,AP2S1,DPH2,CLEC4F,AAAS,RTN4,ANG,AKAP12,FYN,GSTM5,BTG3,HEATR1,TTLL4,SLC1A3,GOLGA3,RCOR2,ABCA5,CORO2B,THBS3,EIF4EBP1,MCOLN1,STOM,LYZ,CES1,KAT2B,JUN,ZNF334,PDE3B,CLEC14A,CD24,MYO1D,NPTXR,ZFAND2B,ECM2,FUK,PLXNA1,CEP164,MYOM2,LRSAM1,NBEA,SLIT2,TMEM42,AXL,EMC1,GABRE,PLA2G2A,DCAF13,IMMT,RNF144A,GALE,ANXA3,CILP,ATAD3A,TM4SF1,LRFN4,TFF3,FARP1,FAT1,MAP1B,PIGQ,WDR5,ALDH1A1,MYOM1,TTLL12,PLA2G5,AMPH,GSK3B,GPC1,RET,KLHDC3,HK1,MT1G,TTYH1,PTPRE,ACSL3,HNMT,TRIOBP,GSDMB,RPUSD1,TALDO1,MAPK8IP3,KIAA0922,PRKCD,N6AMT1,C2orf40,IDO1,CRABP2,SH3BP4,SH3RF3,SLC4A11,IPO9,CD55,NFKBIA,HSPE1,SMO,CFB,STK24,IFRD1,KCTD1,GOT2,MAPKAPK2,ACADM,CHEK2,ADRB2,ZFP42,EMILIN1,EPAS1,PHLDA3,DHX37,CIART,COLEC11,C2orf88,EPHB3,GBE1,PDE8B,C6,KDR,DHRS7B,NDUFA9,WBSCR22,ASCC1,C1QC,SERPINA3,FADS3,ZNF263,EGR2,CTSH,KEAP1,LUM,MGP,MTHFD2,CEP170B,KANK3,CAV1,ST6GALNAC2,ATF4,EBF2,STK32A,HIPK2,CDC16,RNF121,SELE,PPP1R1B,SMG5,ANO6,MASP1,FLOT1,THOP1,IFNAR2,TFPI2,TMEM127,EVPL,NRDE2,CTSA,LRRN3,VARS2,ATMIN,GAPDH,ITGA1,SAMD4A,CXorf57,FGF2,PHLDA2,CCDC167,UBE2Z,ZBTB9,TOM1L2,LAMP3,HS3ST3A1,TGM2,CS,GADD45A,SORBS1,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,G3BP2,MAPKAP1,NINL,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,LRRC75B,TMEM106C,XAF1,SLC22A18,AARS2,SEMA3C,ABCC3,QPCT,TRAPPC2L,ATP13A1,SESN2,ATP2B1,PTTG1,PARP2,KLF6,POLR3E,STARD7,HSPA5,PADI4,GPR4,KCNAB1,TMEM8B,CAST,PDZRN3,LACTB,LRBA,MAST4,DOK2,GM2A,LAMA2,UNC13B,PTGDS,KLF4,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,RUNX1,TPR,COPE,ABCF1,ATF6,GTF3A,NAT14,KIFC2,CCL3,GCDH,RPL14,POLR1C,MSRB3,SLC19A3,SAA1,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,SLC22A12,TUBG1,EMD,GATSL3,LARP6,CXCL16,ADGRG1,CIDEA,PMP22,CES4A,ASTN2,HEPACAM,ALKBH3,DNM1L,KCNK15,CAMK1,APOB,ITSN1,AHCYL1,TGFBR3,FAM58A,HRAS,SNAP47,RAPH1,SATB2,ANK2,IRS2,PKIA,EYA2,WNT5B,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,PCSK5,RRBP1,TUBB2A,THY1,CPA3,TNK2,CRABP1,CTPS1,TAF9B,COLEC12,CDH2,CDH12,CCND2,CD68,BSG,PTPRB,CDRT1,ADAMTS18,SPINT2,GLUL,ZER1,SFRP1,CYR61,MYEOV,ADM,MME,SPTBN1,HIST1H1C,ADAM17,MSC,SRD5A1,WASF3,ADAP2,TTC1,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,COL5A1,EFNB2,SEC61A1,SLC2A6,CMTM8,SNX10,CLMN,STIM1,SH3GLB2,TPO,PRPF31,PTPRT,AMFR,PI4KA,SLC7A6,MYCN,VPS18,FMO3,ANGPT1,MGMT,MVB12A,DEFB1,CYP1B1,SUPV3L1,RHPN2,KRT8,PLEKHG6,TF,S100A9,CDK20,CNN1,SPRY2,ADCY1,LSP1,MS4A2,NR5A2,ALS2CL,DVL3,FBN2,EFR3A,PHLDA1,SPHK2,XPO5,CXCL12,HARS,TPM1,TUBB,MTCH2,PARVB,TNIP1,ASXL2,SDPR,NEO1,SLC7A5,KLF2,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,ZNF616,FOXC1,PKN1,EPRS,STC1,SRSF3,PPP2R1A,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,RARRES1,SLC7A1,TET1,SMPD1,MYLK,HIF1A,CDKN2B,FAM110B,EVC,COL1A2,EPHB6,SOX17,NFX1,HMOX1,PCK2,CSPG4,KCNMA1,C7,KIT,NEK7,CUL9,ALPL,STK40,PI4KB,ACTN1,PTGER4,MIPEP,CXCR4,QSOX1,ZBTB7C,NEK11,CYTIP,LPAR1,JCHAIN,EDNRA,RTN3,RCAN2	1088	
Cardiovascular System Development and Function, Organismal Development	formation	formation of blood vessel	2.02E-06	 	-1.322	 	-2.524	APOE,CTGF,BMP4,FGF2,TGFBR3,CFC1/CFC1B,CXCL12,TYMP,C1QA,IL6,GPC3,TGFBR2,EFNB2,JUN,CCL2,VEGFD,ENPP2,GSK3B,LTBR,PTK7,AGT,SRC,SELE,ADAMTS1,ANGPT1,PCSK5,CXCR4,SMAD6,PLAUR,JUNB,BRMS1,KIF7,CDH5,ORM1,CAT,ALDH1A2,SPARC,KDR,AKR1B1,MEGF8,ANG,MMP9,mir-21,NRP1	44	
Organismal Survival	survival	survival of organism	2.14E-06	 	0.707	 	-1.515	CTGF,ITSN1,PCLO,ELANE,HRAS,CDKN2C,IL6,SPI1,ODC1,IDUA,NR4A3,ITGA3,RARA,KEAP1,ABCC1,TSC2,HIPK2,MCL1,ETS1,PTGIS,SELE,ARRDC4,COMP,COCH,PPP1R1B,MAD2L2,MMP2,JUNB,THBD,IFNAR2,LDOC1,S1PR3,CARD9,CCND2,STIP1,PPP1R15A,CTSB,GLUL,ITGA1,PLTP,ITGA7,NOTCH1,mir-21,NRP1,COL3A1,ADM,MME,APOE,FCGRT,NME1,LEPR,NQO2,HYOU1,TNFSF10,MEOX2,DDX3X,IDH1,EIF4EBP1,DIABLO,TGM2,ID1,LYZ,CCL2,CCL3L3,SLC19A1,CD24,LBP,PIK3R2,ADORA1,COL18A1,FCGR3A/FCGR3B,ALDH5A1,ATN1,PLAT,CCR1,S100A1,C5AR1,BLMH,UCP2,ANGPT1,MGMT,IGF2R,PLA2G2A,FOS,HP,LY96,LDLR,S100A9,NTRK3,PEA15,ARHGDIA,MAP3K8,TP53BP1,PTGS2,MSRA,GABARAP,SGCD,CH25H,SOCS3,TNFRSF4,ADRBK1,SESN2,ABCA3,CD4,HSPA1A/HSPA1B,KLF6,CXCL12,MYC,TGFBR2,ETS2,SIAH2,GSK3B,ACTG2,LTBR,CAST,RET,NSMAF,BIRC3,GCA,MARCO,PTX3,MIF,SPP1,FST,DOK2,LMNA,GNAZ,ERCC2,EIF4E2,INHBB,BCL2L1,ITGAM,ERCC1,ADRA2A,ORM1,DUSP1,ALDH1A2,IDO1,CD14,FZD5,MDK,CRABP2,ESR1,SLC11A1,TNFAIP8,RUNX1,LITAF,LEP,PKM,ABL1,TNFAIP3,SMPD1,ATF6,IRF3,CCL3,RAMP2,GSTT1,VPS4A,IRAK1,HMOX1,SHC1,ALDH2,RAB5A,AEBP1,HLA-DRB1,NFKBIA,THBS1,SMO,CFB,KIT,ERBB2,MAPKAPK2,NCL,CHEK2,PTGER4,ADRB2,PRNP,AGT,SRC,COL5A2,EPN1,NLRP3,EPAS1,ATP2C1,CXCR4,SMAD6,SNX27,LPAR1,ORM2,GAP43,KDR,CXCL2,MMP9	193	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	Peyronie disease	Peyronie disease	2.14E-06	 	 	 	 	COL5A2,COL4A5,COL6A2,COL12A1,COL8A1,COL15A1,COL1A2,COL16A1,COL5A1,COL1A1,COL5A3,COL6A1,COL6A3,COL22A1,COL11A1,COL18A1,COL3A1,COL7A1	18	
Connective Tissue Disorders	Dupuytren contracture	advanced Dupuytren contracture	2.14E-06	 	 	 	 	COL5A2,COL4A5,COL6A2,COL12A1,COL8A1,COL15A1,COL1A2,COL16A1,COL5A1,COL1A1,COL5A3,COL6A1,COL6A3,COL22A1,COL11A1,COL18A1,COL3A1,COL7A1	18	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	genital tumor	genital tumor	2.18E-06	 	0.037	 	0.518	PCLO,ASS1,VAC14,PAQR7,TLE1,POR,PPRC1,TSC2,VIT,WASH3P,DDIT4,SLX4,KIAA1147,RANBP3,HLA-DRB4,CDH5,ALCAM,C14orf79,BRE,KIAA1217,mir-21,FHL1,GBP1,ADIPOQ,TUBB2B,SYNM,DIABLO,C1R,RABL6,TIPARP,LY6E,EMP3,ID3,GPR183,AFF3,COG5,KIF7,SWAP70,CBS/CBSL,TBC1D8,GCSH,WBP2,AKR1C3,RGCC,TRPM8,TMEM169,DNAJC15,ANKDD1A,TUBA1C,VNN2,TEK,ADAMTS1,KANK1,BCL2L1,CRHBP,PSME4,BAIAP2L2,SUN1,ETV5,FEM1A,ZNF252P,CLUAP1,KCNS3,F8,NLRP3,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,RRAS2,SPARC,ANO3,FECH,TSC22D1,ING1,MED24,EIF3C,ASPSCR1,GFPT1,CTGF,MSRB2,GMDS,PPP4C,SGPL1,SP110,SLC22A15,PRG4,MCL1,PPIL6,PIK3C2B,DFNA5,ATG7,PLEC,HBEGF,TMEM267,GRK5,HMGA1,PARP3,CREB5,SH3GL1,CCDC136,MS4A14,ACAD11,NCLN,NOTCH1,EOGT,NRP1,ILVBL,COL3A1,SORL1,CPSF2,ABI3BP,RP9,ZFP36,LEPR,NQO2,SIN3B,ST6GALNAC4,FKBP1A,CASP4,MEOX2,ATP6AP1,KLF9,ENTPD6,DIP2B,COL22A1,TXNL1,HGS,AHNAK2,LIMCH1,NPRL2,RPS24,NAP1L4,CD209,SLC25A13,BLMH,EGR1,COL12A1,MED30,DDX24,RELN,NTM,DHCR24,PTGS2,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,CLIP3,CLEC3B,TBX15,LHCGR,SLC35F1,DNAJB2,ZNF91,FAM173A,CNDP2,PLCE1,ETS2,DHTKD1,COMT,MCTP1,NMNAT2,NAV1,PGP,EGR3,USP36,FBXO22,PAWR,ATP10A,ZMYND15,TPSAB1/TPSB2,GPR146,SORD,LRRC41,COL6A3,SCRIB,UVRAG,CDK5RAP2,ICK,NGF,PTPRF,SSU72,GNG11,THBS1,ZNF493,TMEM104,ATP2C1,C9orf3,HYAL1,LRRK2,TANC2,ANO2,NCAPH2,COL1A1,PLEKHH1,PAG1,PLP2,SLIT3,NIPA2,SVEP1,SYTL2,MAP6,CACNA1H,SLC35C1,RNF125,SUSD1,ODC1,RNASE4,OGFOD3,NUP93,CYBA,GPRC5C,EFHB,ARHGAP39,SPATA18,ALDH3A1,TSHZ2,NSUN4,ALDH1B1,DPT,PLD3,SOGA1,MFAP5,TNFRSF10B,RUNDC3B,OSBPL10,RPAP3,PLLP,TNPO2,MN1,ZNF606,SLC16A5,ARHGEF6,GCC1,TFRC,IGSF10,PTPRA,NOL7,APOE,NME1,FBXO10,NACC2,PLXNA3,CUBN,IGSF1,GDF15,CDK4,CTDSPL,TECR,ZNF285,IFI27,RNF181,DUSP5,CCL2,SOS1,DAB2,ADORA1,HCAR2,RAD21,CYP51A1,LIG3,SIGMAR1,HELZ,SPRY1,MED20,STON1,ARHGEF5,ZFPM2,LDLR,ATP6V0A2,BMPER,TP53BP1,BMP6,ST3GAL4,ADRA1A,KTN1,MAOA,BZW2,NOC3L,MEGF9,USP5,ABCA3,PPFIBP2,TIGD2,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GPX3,TPRN,CXCL14,ZNF598,GYPE,STAB1,LILRB5,KIF25,RPAP1,FMO4,GULP1,POLR3C,PKP2,STARD5,VEGFC,DCHS1,TLN2,ABCA8,MATN2,GIPC1,APCDD1,ALDH1A2,SORCS2,THAP7,CCPG1,ESR1,LRRC47,S100P,MAST2,POLR3F,PTGFR,ERAP2,FAM107A,CDC20,FRZB,SRPX,SCARA5,DENND4B,ZSWIM3,DCAF4,SLC15A3,GSTT1,SLC2A3,IRAK1,RAP1GDS1,TRIM6,RGS5,AHNAK,TIMP1,OLFML2A,DNAJC4,MCAM,LOC102724428/SIK1,VARS,GJA4,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,UPP1,PGAP2,ZNF16,N4BP1,PSME3,ATIC,SH3PXD2A,CLGN,PHF19,VAV3,LPAR5,SGK1,MAF,ELANE,CDKN2C,GTF2IRD1,HOXA9,NCOA7,NOSIP,SLC4A3,ABR,ZHX2,CSTF2,ALPK1,GUCY1A3,MMP2,IER3,SCNN1D,RAD51D,RAE1,DOCK1,AQP9,MS4A4A,C11orf80,MAP3K20,MS4A7,ALDOA,TRO,LRP8,HSPB7,SLC35A4,HIST2H2AA3/HIST2H2AA4,ALDH4A1,RALA,UQCRH,CHCHD6,KAZN,KHDC1,VCAN,MTOR,SRGAP1,ANXA5,SOCS2,PRKCE,ACSL4,TBCD,LPP,COL18A1,PLAT,PTK7,DNAH6,CYP11A1,C9orf142,GSTM1,MFAP4,PCDH9,STXBP6,COL5A3,CLDN5,MCM2,PEA15,DBNL,SCAMP3,FZD7,ADRBK1,XXYLT1,FNIP2,ARG2,COBL,KPNA2,LTBR,FAM65B,MYO10,AGBL5,ADRA1B,CSF3R,C8orf46,SPP1,ITPR2,ZNF408,PCSK7,LMNA,MYOF,EIF2S2,RPL9,DPP9,PANK1,GSR,HSPA13,THSD7B,AKR1B1,RNPEP,COL7A1,AOC3,DRAP1,ADAMTS7,LEP,FLRT2,ANTXR1,PNMAL1,RAMP2,ADSL,ZMAT3,FLNA,FUBP3,HIST2H2AC,MICALL1,PSMA3,S100A8,RNF144B,MYO16,PRRT3,RAB11FIP3,TMEM132B,SNAPC4,SPOCD1,DLGAP4,LCLAT1,AP3D1,CPED1,F13A1,MKNK2,CSF1R,ENO1,ITPA,LRP1B,DYM,OLFML2B,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,ATP6V1B2,MMP9,SHMT2,CBX7,RPE,AXIN1,PPP2R3B,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,AMHR2,FBL,PTGIS,SLC2A5,NDUFS7,GFM1,PTPN3,CTSB,FTH1,EPHX1,CD163L1,COL4A5,PSMD7,GNA11,MRPL38,COL15A1,DDX3X,DTNA,ABCC9,GTF3C1,MECOM,KIAA1549L,CD69,SLC25A1,SPATS2L,CDO1,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,GCNA,MXRA5,LIG1,SOCS3,MICALL2,RABEP1,AP1B1,CEP104,ZNF75D,ARHGAP20,CCT5,ERAL1,ACTG2,KMT5A,CXCL8,STXBP1,TJP2,ARL17A/ARL17B,H19,MAN1C1,MAPK8IP2,BAMBI,H6PD,FIG4,RAB34,ERCC2,TXNRD1,ADRA2A,GPS1,SLC7A2,BAP1,CCDC80,TNS1,GSDMC,SYN1,SLC11A1,VHL,SULF1,IGFBP4,LITAF,PC,PLGRKT,HABP4,COL6A6,PHLDB2,HLA-G,DHCR7,ESPNL,EDN1,GTPBP2,FARS2,ERBB2,THBS4,SRC,PKP1,NSFL1C,AP3B2,APOLD1,ITM2C,COL11A1,CERCAM,PRUNE2,KCND2,CMTM4,TYRO3,PCDH17,MST1,GHITM,POMC,ACP5,PALMD,NR4A3,EVI5L,ITGA3,LGMN,IRX3,KIF21A,MGAT4B,AFAP1,FAM127A,CAPN5,EFL1,SFRP4,CMKLR1,CAPN6,ZC3HC1,ATP8B4,CEP89,JUNB,MNDA,BCAP29,AP2S1,DPH2,CLEC4F,AAAS,RTN4,ANG,AKAP12,FYN,GSTM5,BTG3,HEATR1,TTLL4,SLC1A3,GOLGA3,RCOR2,ABCA5,CORO2B,THBS3,EIF4EBP1,MCOLN1,STOM,LYZ,CES1,KAT2B,JUN,ZNF334,PDE3B,CLEC14A,CD24,MYO1D,NPTXR,ZFAND2B,ECM2,FUK,PLXNA1,CEP164,MYOM2,LRSAM1,NBEA,SLIT2,TMEM42,AXL,EMC1,GABRE,PLA2G2A,DCAF13,IMMT,RNF144A,GALE,ANXA3,CILP,ATAD3A,TM4SF1,LRFN4,TFF3,FARP1,FAT1,MAP1B,PIGQ,WDR5,ALDH1A1,MYOM1,TTLL12,PLA2G5,AMPH,GSK3B,GPC1,RET,KLHDC3,HK1,MT1G,TTYH1,PTPRE,ACSL3,HNMT,TRIOBP,GSDMB,RPUSD1,TALDO1,MAPK8IP3,KIAA0922,PRKCD,N6AMT1,C2orf40,IDO1,CRABP2,SH3BP4,SH3RF3,SLC4A11,IPO9,CD55,NFKBIA,HSPE1,SMO,CFB,STK24,IFRD1,KCTD1,GOT2,MAPKAPK2,ACADM,CHEK2,ADRB2,ZFP42,EMILIN1,EPAS1,PHLDA3,DHX37,CIART,COLEC11,C2orf88,EPHB3,GBE1,PDE8B,C6,KDR,DHRS7B,NDUFA9,WBSCR22,ASCC1,C1QC,SERPINA3,FADS3,ZNF263,EGR2,CTSH,KEAP1,LUM,MGP,MTHFD2,CEP170B,KANK3,CAV1,ST6GALNAC2,ATF4,EBF2,STK32A,HIPK2,CDC16,RNF121,SELE,PPP1R1B,SMG5,ANO6,MASP1,FLOT1,THOP1,IFNAR2,TFPI2,TMEM127,EVPL,NRDE2,CTSA,LRRN3,VARS2,ATMIN,GAPDH,ITGA1,SAMD4A,CXorf57,FGF2,PHLDA2,CCDC167,UBE2Z,ZBTB9,TOM1L2,LAMP3,HS3ST3A1,TGM2,CS,GADD45A,SORBS1,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,G3BP2,MAPKAP1,NINL,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,LRRC75B,TMEM106C,XAF1,SLC22A18,AARS2,SEMA3C,ABCC3,QPCT,TRAPPC2L,ATP13A1,SESN2,ATP2B1,PTTG1,PARP2,KLF6,POLR3E,STARD7,HSPA5,PADI4,GPR4,KCNAB1,TMEM8B,CAST,PDZRN3,LACTB,LRBA,MAST4,DOK2,GM2A,LAMA2,UNC13B,PTGDS,KLF4,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,RUNX1,TPR,COPE,ABCF1,ATF6,GTF3A,NAT14,KIFC2,CCL3,GCDH,RPL14,POLR1C,MSRB3,SLC19A3,SAA1,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,SLC22A12,TUBG1,EMD,GATSL3,LARP6,CXCL16,ADGRG1,CIDEA,PMP22,CES4A,ASTN2,HEPACAM,ALKBH3,DNM1L,KCNK15,CAMK1,APOB,ITSN1,AHCYL1,TGFBR3,FAM58A,HRAS,SNAP47,RAPH1,SATB2,ANK2,IRS2,PKIA,EYA2,WNT5B,CACHD1,CALCRL,ITM2A,NDRG1,SLC24A3,PCSK5,RRBP1,TUBB2A,THY1,CPA3,TNK2,CRABP1,CTPS1,TAF9B,COLEC12,CDH2,CDH12,CCND2,CD68,BSG,PTPRB,CDRT1,ADAMTS18,SPINT2,GLUL,ZER1,SFRP1,CYR61,MYEOV,ADM,MME,SPTBN1,HIST1H1C,ADAM17,MSC,SRD5A1,WASF3,ADAP2,TTC1,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,COL5A1,EFNB2,SEC61A1,SLC2A6,CMTM8,SNX10,CLMN,STIM1,SH3GLB2,TPO,PRPF31,PTPRT,AMFR,PI4KA,SLC7A6,MYCN,VPS18,FMO3,ANGPT1,MGMT,MVB12A,DEFB1,CYP1B1,SUPV3L1,RHPN2,KRT8,PLEKHG6,TF,S100A9,CDK20,CNN1,SPRY2,ADCY1,LSP1,MS4A2,NR5A2,ALS2CL,DVL3,FBN2,EFR3A,PHLDA1,SPHK2,XPO5,CXCL12,HARS,TPM1,TUBB,MTCH2,PARVB,TNIP1,ASXL2,SDPR,NEO1,SLC7A5,KLF2,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,ZNF616,FOXC1,PKN1,EPRS,STC1,SRSF3,PPP2R1A,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,RARRES1,SLC7A1,TET1,SMPD1,MYLK,HIF1A,CDKN2B,FAM110B,EVC,COL1A2,EPHB6,SOX17,NFX1,HMOX1,PCK2,CSPG4,KCNMA1,C7,KIT,NEK7,CUL9,ALPL,STK40,PI4KB,ACTN1,PTGER4,MIPEP,CXCR4,QSOX1,ZBTB7C,NEK11,CYTIP,LPAR1,JCHAIN,EDNRA,RTN3,RCAN2	1088	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	cellular infiltration of phagocytes	2.18E-06	 	-1.071	 	-2.085	CTGF,UNC5B,CXCL12,HRAS,IL6,TGFBR2,IKBKG,CAV1,TNFRSF21,PTX3,CMKLR1,SELE,MIF,SPP1,NDRG1,THBD,NINJ1,STC1,PRKCD,PPP1R15A,CD86,PLTP,CYR61,APOE,ADAM17,LEP,NQO2,ADIPOQ,TNFAIP3,HIF1A,CCL3,HMOX1,CES1,GBA,EDN1,CCL2,DUSP10,SAA1,AGT,IL11RA,CCR1,NLRP3,C5AR1,NQO1,PCOLCE2,SMAD7,SLIT2,NFKBIZ,CSF1R,PLA2G4A,LDLR,VAV3,MAP3K8,C6,PTGS2,KDR,P2RX7,MMP9	58	
Cellular Movement	cell movement	cell movement of connective tissue cells	2.21E-06	 	0.189	bias	-1.638	CTGF,ITGB1BP1,HRAS,IL6,SDC4,MYC,TGFBR2,SGPL1,RHOB,CAV1,WNT5B,ELN,CALCRL,MIF,DPT,SPP1,TMEM201,PLEC,HBEGF,S1PR3,PRKCD,LIMA1,CAPN2,RAMP3,CYR61,PDGFD,PTPRA,TNS1,mir-21,COL7A1,APOE,SLC4A2,LEP,FGF2,BMP2,ABL1,ADIPOQ,CCL3,RAMP2,ENAH,JUN,EDN1,CCL2,RHOD,KCNMA1,THBS1,SMO,CYGB,PRKCE,ENPP2,ERBB2,MAPKAPK2,LPP,AGT,SRC,ANGPT1,ARHGAP4,PLAUR,IGF2R,CSF1R,FOS,COL1A1,CXCL16,CAPNS1,LPAR1,S1PR1,MAP3K8	67	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	smooth muscle tumor	smooth muscle tumor	2.28E-06	 	 	 	 	SOCS3,MEGF9,RPE,AHCYL1,PTTG1,MAF,LHCGR,PPP4C,MYC,NR4A3,ALDH1A1,CYBA,SDPR,CXCL14,MTHFD2,ERAL1,PKIA,WNT5B,ADRA1B,PDK4,SLC2A5,ALDH1B1,CALCRL,CAPN6,DPT,HNMT,SPP1,PLD3,H19,NDRG1,NDUFS7,SLC24A3,MMP2,HMGA1,AP2S1,RPL9,KCNG1,ABCA8,ADRA2A,COL6A3,DUSP1,ALDOA,HSPB7,SFRP1,CRABP2,CYR61,AK2,ESR1,mir-21,FTH1,POLR3F,NOL7,UQCRH,FGF2,PHLDA2,SCARA5,SLC7A1,RAMP2,VCAN,EIF4EBP1,SHC1,GNG11,JUN,RGS5,KIT,MICALL1,CD24,ECM2,PI4KA,PTGER4,ADRB2,DLGAP4,HYAL1,DDX24,CLEC16A,STXBP6,CSF1R,CYP1B1,FOS,NR4A2,LSP1,LYN,XAF1,NR5A2,PTGS2,ADRA1A,MAOA	87	
Cell Death and Survival	cell death	cell death of central nervous system cells	2.32E-06	 	-0.871	 	-0.670	KCND2,SERPINI1,ITSN1,ADRBK1,SGK1,KLF6,MAP1B,CXCL12,SH3GLB1,SERPINA3,HSPA5,CTSD,ETS2,TSC2,DLG4,GCLM,GSK3B,CAST,RTN4R,UNG,PFKFB3,CXCL8,MIF,ATG7,HBEGF,PAWR,JUNB,MAP3K12,BCL2L1,DUSP1,PRKCD,STIP1,GAPDH,MAP2K3,SLC25A10,MAPK7,MAP2K5,RUNX1,APOE,LEP,DDIT3,KCNK3,BMP2,VAPA,BCL2L12,ABL1,CDK4,HYOU1,TNFSF10,CADPS2,HIF1A,NGF,GLRX,TGM2,MTOR,NFKBIA,JUN,GBA,EDN1,C7,RPS6KB2,RASSF5,ADORA1,ATP13A2,PLAT,PRNP,PRPH,SRC,UCP2,ATP2C1,EGR1,FAM134B,FAIM,SH3PXD2A,FOS,CAPNS1,TF,NTRK3,CAT,PEA15,PTGS2,PIN1,DNM1L,MAOA	84	
Molecular Transport	export	export of molecule	2.32E-06	Increased	2.157	bias	0.092	APOB,SYTL2,AHCYL1,SGK1,CD36,RAN,XPO5,CXCL12,HRAS,LIPE,ABCG1,IL6,SLC8B1,EGR2,CSE1L,ABCC1,SLC16A2,CAV1,SLC7A5,LSS,GSK3B,CLCN3,NUP155,SEC13,HSPA9,SMG5,STX1A,RAE1,SRSF3,BCL2L1,NPR3,BSG,PKD1,CD14,LMAN2L,ATOX1,PLTP,SLC11A1,XPO6,FTH1,APOE,FYN,LEP,SLC1A5,FGF2,GDF15,TPR,ADIPOQ,XPOT,CRAT,THOC3,SMPD1,ABCA5,IFI27,IRAK1,HMOX1,AEBP1,CES1,NFKBIA,EDN1,CCL2,SAA1,LIPG,S100A8,CHCHD4,CRYM,HCAR2,ABHD5,SLC22A12,SLC12A2,SNTB1,CANX,SLC25A1,RELN,LDLR,S100A9,SMG7,APOC1,ACAT1,NR5A2,PTGS2,ABCC3,P2RX7,SLC47A1	84	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of myeloid cells	2.34E-06	 	0.000	bias	-0.516	CD36,TYRO3,UNC5B,PLA2G15,ELANE,CXCL12,FCER1A,MST1,IL6,PADI4,IDUA,LGMN,PLA2G5,CAV1,CLCN3,BIRC3,RASGRP2,STX11,MARCO,CXCL8,MIF,SELE,SPP1,DOK2,CAPG,NLRX1,APBA3,CARD9,ITGAM,PRKCD,CD14,CNN2,FYN,APOE,SFTPD,ZFP36,GDF15,ADIPOQ,SMPD1,G6PC3,IRAK1,HLA-G,MCOLN1,MTOR,NFKBIA,CCL2,CSPG4,LBP,PTGER4,PLAT,FCER2,CCR1,SIGMAR1,NLRP3,UCP2,TYROBP,EGR1,PLAUR,AXL,CSF1R,GRN,FOS,PLA2G4A,LY96,FASTK,LYN,FCER1G,PTGS2,P2RX7,MMP9	70	
Organismal Injury and Abnormalities	bleeding	Bleeding	2.35E-06	 	-1.104	bias	2.932	TYRO3,ELANE,POMC,IL6,POR,MGP,HEY2,KAT2A,ALDH3A1,TNFRSF21,SELE,PCSK5,PLEC,C1GALT1C1,PLOD1,S1PR3,IFT122,VKORC1,MAPK7,NRP1,ADM,FCGRT,APOE,ADAM17,DDIT3,GNA11,ADIPOQ,CDK4,FKBP1A,IDH1,ID1,LLGL1,CST3,COL18A1,ADORA1,FCGR3A/FCGR3B,HEY1,PLAT,MYCN,ANGPT1,MECOM,CUL7,AXL,ID3,GABRE,PLA2G2A,GRN,PLA2G4A,KRT8,ZFPM2,S100A9,TF,NTRK3,CNN1,S1PR1,MAP3K8,PTGS2,ZFP36L2,ARID4A,ADRA1A,ADGRA2,ABCA3,SPHK2,TGFBR2,RSPO3,IKBKG,ALDH1A1,GPR4,OSR1,CAST,BIRC3,KLF2,ADRA1B,TEK,FERMT3,PTX3,MIF,SPP1,PKP2,PKD1,ADRA2A,ASIC1,CAPN2,FZD5,ESR1,VHL,RUNX1,LOX,ERN1,FLRT2,ABL1,ATF6,RAMP2,F8,FLNA,THBS1,TIMP1,MKL2,RPS6KB2,KIT,ALPL,PTGER4,ADRB2,AGT,GJA4,EPAS1,ATP2C1,CXCR4,SLC12A2,G6PD,F13A1,FAIM,COL1A1,CAPNS1,LPAR1,EDNRA,DNM1L,EFEMP2,MMP9	119	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of cancer cells	2.36E-06	 	-1.810	 	-0.821	EIF3C,BMP4,RAN,SERPINA3,IL6,SPI1,EIF3B,CSE1L,KEAP1,RARA,TXN,HIPK2,MCL1,ETS1,CAPN6,ATG7,NDRG1,TNFRSF10B,MAD2L2,RTN4,CTSB,PSMA4,EBNA1BP2,ITGA1,RPL6,SFRP1,CYR61,PTPRA,NOTCH1,mir-21,ZFP36,DDIT3,FGF2,LEPR,GDF15,ADIPOQ,TNFSF10,SF3B3,DIABLO,TRIB1,MTOR,JUN,CD24,PRKCE,COL18A1,RPS24,MYCN,ACLY,FOS,NR4A2,TF,MCM2,SPRY2,PTGS2,BMP6,PHLDA1,SOCS3,HSPA1A/HSPA1B,CXCL12,MYC,PUF60,GSK3B,CXCL8,MIF,NUP155,PSMB5,HSPA9,POLR2H,VEGFC,PAWR,RPL9,STC1,BCL2L1,PRKCD,IGFBP3,VHL,UBE2I,RUNX1,SFRP2,LEP,BMP2,ABL1,HIF1A,NGF,HMOX1,NFKBIA,KIT,PSMA3,ISCU,SEMA3B,ERBB2,PRNP,BEX2,CD59,VCAM1,SNRPB,CXCR4,LRRK2,RPS21,TNFRSF14,BTK,ENO1,LPAR1,CAT,SPARC,TSC22D1,KDR,MMP9,RPLP0	109	
Cancer, Organismal Injury and Abnormalities	cancer	stage 3 cancer	2.36E-06	 	 	 	 	SQLE,NME1,PARP2,ABL1,LHCGR,FKBP1A,SIL1,MYC,TGFBR2,NEU1,COL1A2,HMOX1,MTOR,JUN,MAP2K2,CAV1,LOC102724428/SIK1,KIT,TUBA1C,ERBB2,RET,GJB2,IGFBP6,SRC,PSMB5,SPP1,TUBG1,TUBB2A,MMP2,PARP3,TNK2,ERCC2,IFNAR2,ATIC,BTK,NEK11,KRT8,C19orf53,PSMB2,GIPC1,TMEM106C,CCT3,PTGS2,AIDA,KDR,ESR1,MMP9,VHL	48	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of blood cells	2.37E-06	 	0.056	 	-2.006	C1QA,IL6,SLC35C1,SPI1,EGR2,CCND3,LUM,ST6GALNAC2,ATF4,TNFRSF21,ETS1,RBM38,CLEC4G,SELE,MFAP5,IFNAR2,HAX1,NPR3,PPP1R15A,ARHGEF6,TFRC,CD86,APOE,GADD45B,DDIT3,GDF15,ACKR2,ADIPOQ,CDK4,G6PC3,DIABLO,TGM2,CCL2,GADD45A,SORBS1,IL34,CCR1,TSTA3,MECOM,CD69,TOB1,CBR3,IGF2R,ID3,GPR183,FOS,ARHGEF5,SWAP70,LDLR,CBS/CBSL,LYN,ARHGDIA,TP53BP1,MAP3K8,NDST2,ST3GAL4,LIG1,SOCS3,PTTG1,HAVCR2,MBP,POLR3E,FCER1A,ABCG1,STARD7,GPC3,MYC,TGFBR2,CTSD,ADGRF5,CXCL14,STAB1,NEDD4L,BIRC3,TEK,CXCL8,ATF3,DOK2,LAMA2,THRA,KLF4,FOSB,BCL2L1,DUSP1,FAM26F,IGFBP3,MDK,ESR1,VHL,RUNX1,LITAF,SFTPD,MPZL2,CCL3,ETV6,IRAK1,CIAPIN1,HLA-G,SHC1,ALDH2,HLA-DRB1,TIMP1,SAA1,MKL2,ERBB2,AGT,SLC20A1,SRC,VCAM1,NQO1,ST3GAL6,PSME3,NFE2L1,BTK,CXCL16,RCAN1,CAPNS1,VAV3,CXCL2,APOB,BMP4,TYRO3,MAF,HRAS,CDKN2C,HOXA9,SGPL1,MFAP2,ITGA3,LGMN,RARA,MGAT4B,DNAJA3,APEX2,MATK,MCL1,CALCRL,CMKLR1,ATG7,DKC1,HBEGF,THBD,S1PR3,CCND2,EPB42,IL10RA,MAPK7,SAC3D1,NOTCH1,CNN2,FYN,ADAM17,ZFP36,PSMB10,LEPR,NQO2,SIN3B,TNFSF10,MYH11,EFNB2,ID1,TRIB1,CES1,JUN,GBA,CCL3L3,SLC19A1,PRKCE,LIPG,RASSF5,PLAT,MYCN,C5AR1,TYROBP,IMPDH2,EGR1,HDC,AXL,TF,S100A9,WAS,BMF,LSP1,FCER1G,BNIP3L,PTGS2,ZFP36L2,NEDD9,ARID4A,RGS1,TNFRSF4,CD36,CD4,SPHK2,PLA2G15,LHCGR,CXCL12,TNIP1,IKBKG,PLCE1,ETS2,COMT,LTBR,KLF2,STX11,FERMT3,EIF2AK1,CSF3R,MIF,SPP1,DNASE2,EGR3,HSPA9,FZD9,PAWR,PKN1,ITGAM,ERCC1,PRKCD,IDO1,UVRAG,LEP,ABL1,SLC7A1,TNFAIP3,TET1,SMPD1,HIF1A,NGF,CDKN2B,HMOX1,HINT1,NFKBIA,THBS1,DKK3,FLNA,DUSP10,SMO,KIT,S100A8,HCST,MAPKAPK2,ALPL,PRNP,RHBDD3,FAAH,CD59,EPAS1,CYP27A1,CXCR4,VSIG4,F13A1,CCDC3,IL20RB,CSF1R,EBF1,CYTIP,PAG1,FASTK,JCHAIN,ACAT1,C6,KDR,P2RX7,MMP9,CLEC10A,CARM1	267	
Cancer, Organismal Injury and Abnormalities	pelvic cancer	pelvic cancer	2.41E-06	 	0.243	 	0.299	PCLO,ASS1,VAC14,PAQR7,TLE1,POR,AJUBA,PPRC1,TSC2,VIT,WASH3P,ETS1,DDIT4,SLX4,KIAA1147,RANBP3,HLA-DRB4,CDH5,ALCAM,C14orf79,BRE,KIAA1217,mir-21,FHL1,GBP1,ADIPOQ,MFSD5,TUBB2B,SYNM,DIABLO,C1R,RABL6,TIPARP,LY6E,EMP3,RNF157,ID3,PAMR1,GPR183,PDZD2,AFF3,COG5,KIF7,SWAP70,CBS/CBSL,TBC1D8,GCSH,WBP2,CYP4F11,AKR1C3,RGCC,TRPM8,TMEM169,DNAJC15,ANKDD1A,TUBA1C,VNN2,BIRC3,TEK,ADAMTS1,GNAZ,KANK1,BCL2L1,CRHBP,PSME4,BAIAP2L2,RAB11FIP5,SUN1,ETV5,FEM1A,ZNF252P,CLUAP1,KCNS3,SH3PXD2B,F8,NLRP3,PLAUR,SAA2,SNX27,FRMD4A,CLEC16A,RRAS2,SPARC,ANO3,FECH,TSC22D1,ING1,MED24,ASPSCR1,GFPT1,CTGF,MSRB2,GMDS,PPP4C,SGPL1,SP110,SLC22A15,PRG4,MCL1,PPIL6,PIK3C2B,BIRC7,DFNA5,ATG7,PLEC,HBEGF,TMEM267,GRK5,HMGA1,PARP3,CREB5,NINJ1,SH3GL1,CCDC136,MS4A14,FAM86B1,ACAD11,ISLR,NCLN,NOTCH1,EOGT,NRP1,ILVBL,COL3A1,SORL1,CPSF2,ABI3BP,RP9,ZFP36,LEPR,NQO2,SIN3B,ST6GALNAC4,FKBP1A,CASP4,MEOX2,ATP6AP1,KLF9,ENTPD6,DIP2B,COL22A1,TXNL1,HGS,AHNAK2,GJB2,NPRL2,LIMCH1,RPS24,NAP1L4,CD209,SLC25A13,STAMBPL1,EGR1,COL12A1,MED30,DDX24,RELN,NTM,COPS3,DHCR24,TMEM63B,PTGS2,FBXW9,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,CLIP3,CLEC3B,TBX15,LHCGR,SLC35F1,DNAJB2,ZNF91,FAM173A,CNDP2,PLCE1,ETS2,DHTKD1,COMT,MCTP1,NMNAT2,NAV1,PGP,EGR3,USP36,FBXO22,PAWR,ATP10A,ALAD,ZMYND15,TPSAB1/TPSB2,GPR146,SORD,LRRC41,COL6A3,SCRIB,UVRAG,CDK5RAP2,ICK,NGF,PTPRF,SSU72,THBS1,ZNF493,TMEM104,ATP2C1,C9orf3,LRRK2,TANC2,ANO2,NCAPH2,COL1A1,PLEKHH1,PAG1,PLP2,SLIT3,NIPA2,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,SLC35C1,RNF125,SUSD1,ODC1,RNASE4,OGFOD3,NUP93,CYBA,EFHB,ARHGAP39,SPATA18,ALDH3A1,TSHZ2,NSUN4,ALDH1B1,DPT,SOGA1,MFAP5,TNFRSF10B,CARMIL1,RUNDC3B,OSBPL10,RPAP3,PLLP,TNPO2,MN1,ZNF606,SLC16A5,PPP1R15A,ARHGEF6,GCC1,TFRC,IGSF10,PTPRA,APOE,NME1,FBXO10,NACC2,PLXNA3,IGSF1,CUBN,GDF15,CDK4,CTDSPL,TECR,ZNF285,IFI27,DUSP5,CCL2,SOS1,DAB2,ADORA1,HCAR2,RAD21,CYP51A1,C11orf54,LIG3,SIGMAR1,HELZ,MED20,STON1,ARHGEF5,ZFPM2,LDLR,ATP6V0A2,BMPER,TP53BP1,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,BZW2,NOC3L,USP5,ABCA3,HSPA1A/HSPA1B,PPFIBP2,TIGD2,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GPX3,TPRN,RHOB,CXCL14,ZNF598,GIMAP5,GYPE,STAB1,LILRB5,KIF25,FMO4,RPAP1,GULP1,POLR3C,ATF3,PKP2,STARD5,VEGFC,DCHS1,FOSB,TLN2,ABCA8,MATN2,GIPC1,APCDD1,ALDH1A2,SORCS2,THAP7,CCPG1,ESR1,LRRC47,S100P,MAST2,PTGFR,ERAP2,FAM107A,CDC20,FRZB,SRPX,DENND4B,ZSWIM3,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,RGS5,AHNAK,TIMP1,OLFML2A,DNAJC4,MCAM,MEX3B,LOC102724428/SIK1,VARS,GJA4,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,PGAP2,ZNF16,N4BP1,PSME3,ATIC,SH3PXD2A,CLGN,VAV3,LPAR5,MIB2,SGK1,MAF,ELANE,CDKN2C,GTF2IRD1,HOXA9,NCOA7,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,CSTF2,ALPK1,GUCY1A3,MMP2,IER3,SCNN1D,RAD51D,RAE1,DOCK1,AQP9,SRGAP3,MS4A4A,C11orf80,MAP3K20,MS4A7,TRO,LRP8,SLC35A4,HIST2H2AA3/HIST2H2AA4,ALDH4A1,RALA,CHCHD6,KHDC1,VCAN,MTOR,SRGAP1,ANXA5,SOCS2,ACSL4,PRKCE,TBCD,LPP,COL18A1,PLAT,PTK7,DNAH6,CYP11A1,C9orf142,GSTM1,MFAP4,STXBP6,PCDH9,COL5A3,CLDN5,MCM2,CHFR,PEA15,DBNL,ZFP36L2,SCAMP3,VPS52,MAPRE3,FZD7,NAGK,ADRBK1,XXYLT1,FNIP2,ARG2,COBL,KPNA2,FAM65B,MYO10,ACTA1,AGBL5,ADRA1B,CSF3R,C8orf46,SPP1,NUP155,ITPR2,ZNF408,PCSK7,LMNA,MYOF,EIF2S2,DPP9,GSR,PANK1,RRP7A,HSPA13,THSD7B,AKR1B1,RNPEP,COL7A1,AOC3,DRAP1,ADAMTS7,LEP,FLRT2,ANTXR1,PNMAL1,RAMP2,ADSL,ZMAT3,FLNA,FUBP3,HIST2H2AC,PSMA3,S100A8,RNF144B,MYO16,PRRT3,TMEM132B,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,AP3D1,CPED1,F13A1,MKNK2,CSF1R,ENO1,ITPA,LRP1B,DYM,OLFML2B,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,ATP6V1B2,MMP9,SHMT2,CBX7,SLC6A9,AXIN1,PPP2R3B,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,AMHR2,FBL,PTGIS,GFM1,PTPN3,CTSB,EPHX1,CD163L1,COL4A5,PSMD7,MRPL38,COL15A1,DDX3X,DTNA,ABCC9,GTF3C1,MECOM,KIAA1549L,CD69,SPATS2L,CDO1,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,LIG1,SOCS3,MICALL2,RABEP1,AP1B1,CEP104,ZNF75D,ARHGAP20,CCT5,ACTG2,KMT5A,CXCL8,STXBP1,TJP2,ARL17A/ARL17B,H19,MAN1C1,STK39,MAPK8IP2,BAMBI,H6PD,FIG4,RAB34,ERCC2,TXNRD1,ADRA2A,GPS1,SLC7A2,BAP1,CCDC80,TNS1,GSDMC,SYN1,SLC11A1,VHL,SULF1,IGFBP4,LITAF,PC,PLGRKT,HABP4,COL6A6,PHLDB2,HLA-G,DHCR7,ESPNL,EDN1,GTPBP2,FARS2,ERBB2,THBS4,SRC,PKP1,NSFL1C,AP3B2,APOLD1,POLR3B,ITM2C,COL11A1,CERCAM,PRUNE2,KCND2,CMTM4,TYRO3,PCDH17,MST1,GYG2,GHITM,POMC,ACP5,PALMD,EVI5L,ITGA3,LGMN,IRX3,KIF21A,MGAT4B,AFAP1,FAM127A,CAPN5,EFL1,SFRP4,CMKLR1,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MNDA,ROR1,BCAP29,DPH2,CLEC4F,AAAS,PDE1B,RTN4,ANG,FYN,GSTM5,BTG3,HEATR1,TTLL4,SLC1A3,GOLGA3,ATAT1,RCOR2,ABCA5,CORO2B,THBS3,EIF4EBP1,MCOLN1,STOM,LYZ,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,CLEC14A,CD24,MYO1D,NPTXR,ZFAND2B,ECM2,FUK,PLXNA1,CEP164,MYOM2,WDR55,LRSAM1,NBEA,SLIT2,TMEM42,AXL,EMC1,GABRE,PLA2G2A,DCAF13,IMMT,RNF144A,GALE,ANXA3,CILP,ATAD3A,TM4SF1,LRFN4,TFF3,FARP1,FAT1,MAP1B,PIGQ,WDR5,ALDH1A1,MYOM1,TTLL12,PLA2G5,AMPH,GSK3B,GPC1,RET,STX11,KLHDC3,HK1,FERMT3,MT1G,TTYH1,PTPRE,ACSL3,TRIOBP,GSDMB,RPUSD1,TALDO1,MAPK8IP3,GPAA1,KIAA0922,PRKCD,N6AMT1,C2orf40,IDO1,CRABP2,SH3BP4,SH3RF3,SLC4A11,IPO9,CD55,NFKBIA,HSPE1,SMO,CFB,STK24,IFRD1,KCTD1,GOT2,MAPKAPK2,ACADM,CHEK2,ADRB2,ZFP42,EMILIN1,EPAS1,PHLDA3,DHX37,CIART,COLEC11,C2orf88,EPHB3,GBE1,PDE8B,C6,KDR,DHRS7B,NDUFA9,WBSCR22,ASCC1,C1QC,SERPINA3,PLEKHM2,CLIP1,FADS3,ZNF263,EGR2,CTSH,KEAP1,IQCC,LUM,MTHFD2,CEP170B,ST6GALNAC2,KANK3,MGP,CAV1,ATF4,STK32A,EBF2,HIPK2,CDC16,PIGT,RNF121,TM6SF1,SELE,PPP1R1B,ANO6,SMG5,MASP1,FLOT1,THOP1,IFNAR2,TFPI2,SHROOM4,TMEM127,EVPL,NRDE2,CTSA,LRRN3,VARS2,ATMIN,GAPDH,ITGA1,CXorf57,SAMD4A,FGF2,CCDC167,UBE2Z,ZBTB9,TOM1L2,LAMP3,MRPL22,TGM2,CS,SORBS1,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,G3BP2,MAPKAP1,NINL,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,LRRC75B,TMEM106C,XAF1,SLC22A18,AARS2,SEMA3C,ABCC3,QPCT,TRAPPC2L,ATP13A1,SESN2,ATP2B1,PTTG1,MBP,PARP2,KLF6,POLR3E,STARD7,HSPA5,PADI4,GPR4,KCNAB1,TMEM8B,CAST,PDZRN3,LACTB,LRBA,MAST4,DOK2,GM2A,LAMA2,SRPRB,UNC13B,PTGDS,OSBPL7,KLF4,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,RUNX1,TPR,COPE,ABCF1,ATF6,GTF3A,NAT14,KIFC2,CCL3,GCDH,RPL14,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,SUGP2,SLC22A12,TUBG1,NQO1,EMD,GATSL3,LARP6,CXCL16,ADGRG1,CIDEA,PMP22,CES4A,ASTN2,HEPACAM,ALKBH3,DNM1L,KCNK15,CAMK1,APOB,ITSN1,AHCYL1,WDR45,TGFBR3,FAM58A,HRAS,SNAP47,RAPH1,PCOLCE,SATB2,ANK2,IRS2,EYA2,CACHD1,CALCRL,PEX6,ITM2A,SLC24A3,PCSK5,RRBP1,TUBB2A,THY1,CPA3,TNK2,CRABP1,CTPS1,TAF9B,COLEC12,CDH2,CDH12,CCND2,CD68,BSG,PTPRB,CDRT1,ADAMTS18,ADM2,SPINT2,GLUL,ZER1,SFRP1,CYR61,MYEOV,ADM,MME,SPTBN1,HIST1H1C,MSC,ADAM17,SRD5A1,WASF3,UHRF1BP1,XPOT,ADAP2,TTC1,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,COL5A1,EFNB2,SEC61A1,SLC2A6,CMTM8,SNX10,CLMN,STIM1,SH3GLB2,TPO,KIAA0391,PRPF31,PTPRT,AMFR,PI4KA,SLC7A6,MBOAT7,MYCN,VPS18,FMO3,ANGPT1,TWNK,MGMT,MVB12A,DEFB1,CYP1B1,RHPN2,SUPV3L1,KRT8,PLEKHG6,TF,S100A9,CDK20,CNN1,ADCY1,MS4A2,NR5A2,ALS2CL,DVL3,FBN2,EFR3A,PHLDA1,SPHK2,XPO5,CXCL12,HARS,IL17RC,TPM1,TUBB,MTCH2,PARVB,TNIP1,ASXL2,NEO1,SLC7A5,PUF60,KLF2,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,ZNF616,FOXC1,PKN1,EPRS,STC1,PPP2R1A,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,RARRES1,SLC7A1,TET1,SMPD1,MYLK,ITGA10,HIF1A,CDKN2B,FAM110B,EVC,COL1A2,EPHB6,SOX17,NFX1,HMOX1,PCK2,CSPG4,KCNMA1,C7,KIT,NEK7,ALPL,STK40,PI4KB,ACTN1,PTGER4,MIPEP,CXCR4,QSOX1,ZBTB7C,NEK11,CYTIP,LPAR1,JCHAIN,EDNRA,RTN3,RCAN2	1124	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	migration of mononuclear leukocytes	2.41E-06	 	-0.517	bias	-3.066	CTGF,CTSG,HRAS,IL6,SGPL1,ITGA3,EGR2,ABCC1,MYADM,TNFRSF21,ETS1,CMKLR1,SELE,PLEC,NINJ1,S1PR3,PIP5K1C,CD86,ITGA1,MAPK7,PTPRA,NOTCH1,FYN,ADAM17,ACKR2,HYOU1,TGM2,EFNB2,JUN,CCL2,CCL8,CCL3L3,SOS1,RASSF5,CCR1,CD209,CD69,HDC,RGS16,DEFB1,PVR,GPR183,F11R,FOS,SWAP70,LDLR,WAS,PELI1,PROCR,S1PR1,QPCT,RGS1,SOCS3,RARRES2,TNFRSF4,CD4,SPHK2,CXCL12,FCER1A,HARS,TGFBR2,CYP26B1,IKBKG,STAB1,LTBR,KLF2,FAM65B,FERMT3,CXCL8,MIF,SPP1,EFS,ITGAM,RAP1GAP,CCL18,RUNX1,AOC3,LEP,MYLK,SMPD1,CCL3,NGF,ETV6,HLA-G,THBS1,TIMP1,SAA1,MCAM,ENPP2,ERBB2,AGT,SRC,VCAM1,NLRP3,CXCR4,PLAUR,TNFRSF14,BTK,COL1A1,CXCL16,CYTIP,SPARC,C6,P2RX7,MMP9	105	
Skeletal and Muscular System Development and Function	mineralization	mineralization of bone	2.47E-06	 	-0.224	 	-1.378	NFIX,BMP4,GADD45B,FGF2,BMP2,CRTAP,SIN3B,CLEC3B,HIF1A,GPC3,CCL3,EFNB2,TMEM119,SATB2,ITGA11,OSR1,SRGN,CAV1,MGP,HSD11B2,ATF4,NABP2,ALPL,ADRB2,CCR1,AXIN2,CD276,SPP1,FST,MTSS1,ACP2,COL12A1,LMNA,ANO6,FZD9,GPM6B,ERCC2,CSF1R,EBF1,PDLIM7,CD68,PKD1,S1PR1,SOX9,PTGS2,BMP6,ESR1,RCAN2,P2RX7,FBN2	50	
Cancer, Organismal Injury and Abnormalities	pelvic tumor	pelvic tumor	2.50E-06	 	0.487	 	0.511	PCLO,ASS1,VAC14,PAQR7,TLE1,POR,AJUBA,PPRC1,TSC2,VIT,WASH3P,ETS1,DDIT4,SLX4,KIAA1147,RANBP3,HLA-DRB4,CDH5,ALCAM,C14orf79,BRE,KIAA1217,mir-21,FHL1,GBP1,ADIPOQ,MFSD5,TUBB2B,SYNM,DIABLO,C1R,RABL6,TIPARP,LY6E,EMP3,RNF157,ID3,PAMR1,GPR183,PDZD2,AFF3,COG5,KIF7,SWAP70,CBS/CBSL,TBC1D8,GCSH,WBP2,CYP4F11,AKR1C3,RGCC,TRPM8,TMEM169,DNAJC15,ANKDD1A,TUBA1C,VNN2,BIRC3,TEK,ADAMTS1,GNAZ,KANK1,BCL2L1,CRHBP,PSME4,BAIAP2L2,RAB11FIP5,SUN1,ETV5,FEM1A,ZNF252P,CLUAP1,KCNS3,SH3PXD2B,F8,NLRP3,PLAUR,SAA2,SNX27,FRMD4A,CLEC16A,RRAS2,SPARC,ANO3,FECH,TSC22D1,ING1,MED24,ASPSCR1,GFPT1,CTGF,MSRB2,GMDS,PPP4C,SGPL1,SP110,SLC22A15,PRG4,MCL1,PPIL6,PIK3C2B,BIRC7,DFNA5,ATG7,PLEC,HBEGF,TMEM267,GRK5,HMGA1,PARP3,CREB5,NINJ1,SH3GL1,CCDC136,MS4A14,FAM86B1,ACAD11,ISLR,NCLN,NOTCH1,EOGT,NRP1,ILVBL,COL3A1,SORL1,CPSF2,ABI3BP,RP9,ZFP36,LEPR,NQO2,SIN3B,ST6GALNAC4,FKBP1A,CASP4,MEOX2,ATP6AP1,KLF9,ENTPD6,DIP2B,COL22A1,TXNL1,HGS,AHNAK2,GJB2,NPRL2,LIMCH1,RPS24,NAP1L4,CD209,SLC25A13,STAMBPL1,EGR1,COL12A1,MED30,DDX24,RELN,NTM,COPS3,DHCR24,TMEM63B,PTGS2,FBXW9,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,CLIP3,CLEC3B,TBX15,LHCGR,SLC35F1,DNAJB2,ZNF91,FAM173A,CNDP2,PLCE1,ETS2,DHTKD1,COMT,MCTP1,NMNAT2,NAV1,PGP,EGR3,USP36,FBXO22,PAWR,ATP10A,ALAD,ZMYND15,TPSAB1/TPSB2,GPR146,SORD,LRRC41,COL6A3,SCRIB,UVRAG,CDK5RAP2,ICK,NGF,PTPRF,SSU72,THBS1,ZNF493,TMEM104,ATP2C1,C9orf3,LRRK2,TANC2,ANO2,NCAPH2,COL1A1,PLEKHH1,PAG1,PLP2,SLIT3,NIPA2,HCAR3,SVEP1,SYTL2,MAP6,CACNA1H,SLC35C1,RNF125,SUSD1,ODC1,RNASE4,OGFOD3,NUP93,CYBA,EFHB,ARHGAP39,SPATA18,ALDH3A1,TSHZ2,NSUN4,ALDH1B1,DPT,SOGA1,MFAP5,TNFRSF10B,CARMIL1,RUNDC3B,OSBPL10,RPAP3,PLLP,TNPO2,MN1,ZNF606,SLC16A5,PPP1R15A,ARHGEF6,GCC1,TFRC,IGSF10,PTPRA,APOE,NME1,FBXO10,NACC2,PLXNA3,IGSF1,CUBN,GDF15,CDK4,CTDSPL,TECR,ZNF285,IFI27,DUSP5,CCL2,SOS1,DAB2,ADORA1,HCAR2,RAD21,CYP51A1,C11orf54,LIG3,SIGMAR1,HELZ,SPRY1,MED20,STON1,ARHGEF5,ZFPM2,LDLR,ATP6V0A2,BMPER,TP53BP1,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,BZW2,NOC3L,USP5,ABCA3,HSPA1A/HSPA1B,PPFIBP2,TIGD2,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GPX3,TPRN,RHOB,CXCL14,ZNF598,GIMAP5,GYPE,STAB1,LILRB5,KIF25,FMO4,RPAP1,GULP1,POLR3C,ATF3,PKP2,STARD5,VEGFC,DCHS1,FOSB,TLN2,ABCA8,MATN2,GIPC1,APCDD1,ALDH1A2,SORCS2,THAP7,CCPG1,ESR1,LRRC47,S100P,MAST2,PTGFR,ERAP2,FAM107A,CDC20,FRZB,SRPX,DENND4B,ZSWIM3,DCAF4,SLC15A3,SLC38A1,GSTT1,SLC2A3,IRAK1,RAP1GDS1,HLA-DRB1,TRIM6,RGS5,AHNAK,TIMP1,OLFML2A,DNAJC4,MCAM,MEX3B,LOC102724428/SIK1,VARS,GJA4,SLC20A1,VCAM1,NUSAP1,PARVA,APBB1IP,AP1S2,XRN2,SLC12A2,PGAP2,ZNF16,N4BP1,PSME3,ATIC,SH3PXD2A,CLGN,VAV3,LPAR5,MIB2,SGK1,MAF,ELANE,CDKN2C,GTF2IRD1,HOXA9,NCOA7,NOSIP,SLC4A3,LPIN1,ABR,ZHX2,CSTF2,ALPK1,GUCY1A3,MMP2,IER3,SCNN1D,RAD51D,RAE1,DOCK1,AQP9,SRGAP3,MS4A4A,C11orf80,MAP3K20,MS4A7,TRO,LRP8,SLC35A4,HIST2H2AA3/HIST2H2AA4,ALDH4A1,RALA,CHCHD6,KHDC1,VCAN,MTOR,SRGAP1,ANXA5,SOCS2,ACSL4,PRKCE,TBCD,LPP,COL18A1,PLAT,PTK7,DNAH6,CYP11A1,C9orf142,GSTM1,MFAP4,STXBP6,PCDH9,COL5A3,CLDN5,MCM2,CHFR,PEA15,DBNL,ZFP36L2,SCAMP3,VPS52,MAPRE3,FZD7,NAGK,ADRBK1,XXYLT1,FNIP2,ARG2,COBL,KPNA2,LTBR,FAM65B,MYO10,ACTA1,AGBL5,ADRA1B,CSF3R,C8orf46,SPP1,NUP155,ITPR2,ZNF408,PCSK7,LMNA,MYOF,EIF2S2,DPP9,GSR,PANK1,RRP7A,HSPA13,THSD7B,AKR1B1,RNPEP,COL7A1,AOC3,DRAP1,ADAMTS7,LEP,FLRT2,ANTXR1,PNMAL1,RAMP2,ADSL,ZMAT3,FLNA,FUBP3,HIST2H2AC,PSMA3,S100A8,RNF144B,MYO16,PRRT3,TMEM132B,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,AP3D1,CPED1,F13A1,MKNK2,CSF1R,ENO1,ITPA,LRP1B,DYM,OLFML2B,ZNF585A,RDH5,UBA1,EPB41L2,YME1L1,P2RX7,ATP6V1B2,MMP9,SHMT2,CBX7,SLC6A9,AXIN1,PPP2R3B,NOMO1 (includes others),MTG1,IL6,NPAS2,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,AMHR2,FBL,PTGIS,GFM1,PTPN3,CTSB,EPHX1,CD163L1,COL4A5,PSMD7,GNA11,MRPL38,COL15A1,DDX3X,DTNA,ABCC9,GTF3C1,MECOM,KIAA1549L,CD69,SPATS2L,CDO1,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,LIG1,SOCS3,MICALL2,RABEP1,AP1B1,CEP104,ZNF75D,ARHGAP20,CCT5,ACTG2,KMT5A,CXCL8,STXBP1,TJP2,ARL17A/ARL17B,H19,MAN1C1,STK39,MAPK8IP2,BAMBI,H6PD,FIG4,RAB34,ERCC2,TXNRD1,ADRA2A,GPS1,SLC7A2,BAP1,CCDC80,TNS1,GSDMC,SYN1,SLC11A1,VHL,SULF1,IGFBP4,LITAF,PC,PLGRKT,HABP4,COL6A6,PHLDB2,HLA-G,DHCR7,ESPNL,EDN1,GTPBP2,FARS2,ERBB2,THBS4,SRC,PKP1,NSFL1C,AP3B2,APOLD1,POLR3B,ITM2C,COL11A1,CERCAM,PRUNE2,KCND2,CMTM4,TYRO3,PCDH17,MST1,GYG2,GHITM,POMC,ACP5,PALMD,EVI5L,ITGA3,LGMN,IRX3,KIF21A,MGAT4B,AFAP1,FAM127A,CAPN5,EFL1,SFRP4,CMKLR1,CAPN6,ZC3HC1,DKC1,ATP8B4,CEP89,JUNB,MNDA,ROR1,BCAP29,DPH2,CLEC4F,AAAS,PDE1B,RTN4,ANG,AKAP12,FYN,GSTM5,BTG3,HEATR1,TTLL4,SLC1A3,GOLGA3,ATAT1,RCOR2,ABCA5,CORO2B,THBS3,EIF4EBP1,MCOLN1,STOM,LYZ,CES1,KAT2B,JUN,ZNF334,CSF2RA,PDE3B,CLEC14A,CD24,MYO1D,NPTXR,ZFAND2B,ECM2,FUK,PLXNA1,CEP164,MYOM2,WDR55,LRSAM1,NBEA,SLIT2,TMEM42,AXL,EMC1,GABRE,PLA2G2A,DCAF13,IMMT,RNF144A,GALE,ANXA3,CILP,ATAD3A,TM4SF1,LRFN4,TFF3,FARP1,FAT1,MAP1B,PIGQ,WDR5,ALDH1A1,MYOM1,TTLL12,PLA2G5,AMPH,GSK3B,GPC1,RET,STX11,KLHDC3,HK1,FERMT3,MT1G,TTYH1,PTPRE,ACSL3,TRIOBP,GSDMB,RPUSD1,TALDO1,MAPK8IP3,GPAA1,KIAA0922,PRKCD,N6AMT1,C2orf40,IDO1,CRABP2,SH3BP4,SH3RF3,SLC4A11,IPO9,CD55,NFKBIA,HSPE1,SMO,CFB,STK24,IFRD1,KCTD1,GOT2,MAPKAPK2,ACADM,CHEK2,ADRB2,ZFP42,EMILIN1,EPAS1,PHLDA3,DHX37,CIART,COLEC11,C2orf88,EPHB3,GBE1,PDE8B,C6,KDR,DHRS7B,NDUFA9,WBSCR22,ASCC1,C1QC,SERPINA3,PLEKHM2,CLIP1,FADS3,ZNF263,EGR2,CTSH,KEAP1,IQCC,LUM,MTHFD2,CEP170B,ST6GALNAC2,KANK3,MGP,CAV1,ATF4,STK32A,EBF2,HIPK2,CDC16,PIGT,RNF121,TM6SF1,SELE,PPP1R1B,ANO6,SMG5,MASP1,FLOT1,THOP1,IFNAR2,TFPI2,SHROOM4,TMEM127,EVPL,NRDE2,CTSA,LRRN3,VARS2,ATMIN,GAPDH,ITGA1,CXorf57,SAMD4A,FGF2,CCDC167,UBE2Z,ZBTB9,TOM1L2,LAMP3,MRPL22,TGM2,CS,SORBS1,PIK3R2,TBC1D10B,FCGR3A/FCGR3B,G3BP2,MAPKAP1,NINL,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,FOS,HP,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,LRRC75B,TMEM106C,XAF1,SLC22A18,AARS2,SEMA3C,ABCC3,QPCT,TRAPPC2L,ATP13A1,SESN2,ATP2B1,PTTG1,MBP,PARP2,KLF6,POLR3E,STARD7,HSPA5,PADI4,GPR4,KCNAB1,TMEM8B,CAST,PDZRN3,LACTB,LRBA,MAST4,DOK2,GM2A,LAMA2,SRPRB,UNC13B,PTGDS,OSBPL7,KLF4,SLC3A2,KCNG1,CBX1,ORM1,DUSP1,HIF1AN,IGFBP3,CAPN2,DNAJB6,MEGF8,RUNX1,TPR,COPE,ABCF1,ATF6,GTF3A,NAT14,KIFC2,CCL3,GCDH,RPL14,POLR1C,MSRB3,SHC1,SLC19A3,SAA1,ENPP2,LRPPRC,MCRS1,LONP1,AGT,PSAT1,SUGP2,SLC22A12,TUBG1,NQO1,EMD,GATSL3,LARP6,CXCL16,ADGRG1,CIDEA,PMP22,CES4A,ASTN2,HEPACAM,ALKBH3,DNM1L,KCNK15,CAMK1,APOB,ITSN1,AHCYL1,WDR45,TGFBR3,FAM58A,HRAS,SNAP47,RAPH1,PCOLCE,SATB2,ANK2,IRS2,EYA2,CACHD1,CALCRL,PEX6,ITM2A,SLC24A3,PCSK5,RRBP1,TUBB2A,THY1,CPA3,TNK2,CRABP1,CTPS1,TAF9B,COLEC12,CDH2,CDH12,CCND2,CD68,BSG,PTPRB,CDRT1,ADAMTS18,ADM2,SPINT2,GLUL,ZER1,SFRP1,CYR61,MYEOV,ADM,MME,SPTBN1,HIST1H1C,MSC,ADAM17,SRD5A1,WASF3,UHRF1BP1,XPOT,ADAP2,TTC1,MYH11,DCLK1,VTI1B,RNF24,IDH1,FANCE,UCHL1,COL5A1,EFNB2,SEC61A1,SLC2A6,CMTM8,SNX10,CLMN,STIM1,SH3GLB2,TPO,KIAA0391,PRPF31,PTPRT,AMFR,PI4KA,SLC7A6,MBOAT7,MYCN,VPS18,FMO3,ANGPT1,TWNK,MGMT,MVB12A,DEFB1,CYP1B1,RHPN2,SUPV3L1,KRT8,PLEKHG6,TF,S100A9,CDK20,CNN1,SPRY2,ADCY1,MS4A2,NR5A2,ALS2CL,DVL3,FBN2,EFR3A,PHLDA1,SPHK2,XPO5,CXCL12,HARS,IL17RC,TPM1,TUBB,MTCH2,PARVB,TNIP1,ASXL2,NEO1,SLC7A5,PUF60,KLF2,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,ZNF616,FOXC1,PKN1,EPRS,STC1,PPP2R1A,ITGAM,ERCC1,SRPK3,PKD1,SMOX,SNX1,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,RARRES1,SLC7A1,TET1,SMPD1,MYLK,ITGA10,HIF1A,CDKN2B,FAM110B,EVC,COL1A2,EPHB6,SOX17,NFX1,HMOX1,PCK2,CSPG4,KCNMA1,C7,KIT,NEK7,ALPL,STK40,PI4KB,ACTN1,PTGER4,MIPEP,CXCR4,QSOX1,ZBTB7C,NEK11,CYTIP,LPAR1,JCHAIN,EDNRA,RTN3,RCAN2	1129	
Digestive System Development and Function, Hepatic System Development and Function, Organismal Development	abnormal morphology	abnormal morphology of hepatobiliary system	2.52E-06	 	 	 	 	LIG1,SOCS3,PLIN1,RRM2B,ZFPM1,MST1,IL6,SPI1,TYSND1,IKBKG,MTHFD2,GSK3B,HADHA,MIF,SPP1,LMNA,CTSA,ERCC1,BSG,PKD1,DUSP1,NAGLU,RGN,ESR1,TXNRD2,VHL,COL3A1,B9D1,SPTBN1,APOE,CFC1/CFC1B,ABL1,CDK4,ADIPOQ,CTHRC1,HEXA,SMPD1,ABCA5,VTI1B,RAMP2,CIAPIN1,SLC19A3,AEBP1,MAN2C1,JUN,GBA,THBS1,HMGCL,CCR1,SLC20A1,MYCN,SOX7,NQO1,HYAL1,SNX27,TK2,BSCL2,AGL,IGF2R,NFE2L1,GRN,COL1A1,XYLT2,KRT8,ZFPM2,LDLR,CBS/CBSL,GPBAR1,MAN2B1,PTGS2,ZFP36L2,ARID4A	72	
Skeletal and Muscular System Development and Function	size	size of bone	2.52E-06	 	1.293	 	0.615	BMP4,CTGF,CD36,ITGB1BP1,LHCGR,IL6,PCOLCE,TGFBR2,SATB2,MFAP2,ITGA11,COMT,MGP,CAV1,NABP2,ATF4,GSK3B,HEY2,PDK4,PTPRE,ATG7,SPP1,ACP2,MFAP5,FZD9,THRA,MMP2,JUNB,KLF4,CD68,NPR3,PKD1,CD14,ESR1,NOTCH1,PHLPP1,ADAM17,LEP,SFRP2,NFIX,BTG3,FGF2,LEPR,CRTAP,BMP2,GNA11,ABL1,ADIPOQ,CTHRC1,HEXA,COL1A2,SPON1,EFNB2,ID1,TMEM119,GBA,SMO,FNDC5,HSD11B2,HCST,ALPL,ADRB2,CCR1,PLXNA1,SRC,CTSK,NLRP3,TYROBP,ZNF521,TOB1,CSF1R,CYP1B1,GLG1,FOS,COL1A1,MYOC,LDLR,FCER1G,SOX9,BMP6,MMP9,FBN2	82	
Cancer, Organismal Injury and Abnormalities	serous neoplasm	serous neoplasm	2.54E-06	 	 	 	 	SLIT3,PRUNE2,TGFBR3,CMTM4,MAF,CDKN2C,ACP5,IL6,NPAS2,GTF2IRD1,RNASE4,ITGA3,KEAP1,LUM,MGP,TSHZ2,FBL,PTGIS,SFRP4,DPT,ITM2A,GUCY1A3,MFAP5,RUNDC3B,CPA3,TMEM267,HMGA1,PARP3,CREB5,PLLP,TFPI2,CRABP1,SH3GL1,SPINT2,TRO,LRP8,SFRP1,NOTCH1,COL3A1,HIST2H2AA3/HIST2H2AA4,APOE,HIST1H1C,GSTM5,MEOX2,TTC1,MYH11,DCLK1,COL15A1,LAMP3,SYNM,UCHL1,DTNA,MTOR,CS,TIPARP,CMTM8,DIP2B,SOCS2,CD24,DAB2,TBCD,LPP,ABCC9,ECM2,RAD21,MECOM,ANGPT1,STON1,LRSAM1,MFAP4,MVB12A,SLIT2,CLDN5,KIF7,ZFPM2,PLEKHG6,CBS/CBSL,CDK20,CNN1,GALE,ANXA3,MS4A2,SEMA3C,ZFYVE19,LIG1,FARP1,PTTG1,ABCA3,PARP2,CLEC3B,RGCC,CXCL12,TGFBR2,GPX3,TNIP1,ALDH1A1,DHTKD1,SLC7A5,KPNA2,ACTG2,PDZRN3,FAM65B,FMO4,TEK,PDK4,CXCL8,AXIN2,SPP1,ERCC2,MYOF,TPSAB1/TPSB2,PPP2R1A,ABCA8,MATN2,APCDD1,ALDH1A2,BAP1,THSD7B,AOC3,ERAP2,IGFBP4,FAM107A,CDC20,FRZB,FLRT2,ZSWIM3,PKM,ABL1,MYLK,IRAK1,EPHB6,POLR1C,RGS5,CSPG4,KCNMA1,MCAM,SAA1,C7,CFB,KIT,ENPP2,ERBB2,RNF144B,VARS,GOT2,PI4KB,CHEK2,ADRB2,EMILIN1,THBS4,F13A1,LRRK2,PLAUR,C2orf88,PMP22,VAV3,LPAR5,EDNRA,PDE8B,KDR,ALKBH3	161	
Cancer, Organismal Injury and Abnormalities	head and neck carcinoma	head and neck carcinoma	2.61E-06	 	1.000	 	1.076	CBX7,PCLO,AXIN1,NOMO1 (includes others),IL6,POLRMT,POR,IDUA,UPK3BL,ATG9A,EIF3B,AJUBA,TSC2,DEFB132,PLXNB2,WASH3P,ETS1,COMP,KIAA0513,mir-21,COL15A1,DDX3X,SYNM,SPON1,GPC6,ATN1,MTSS1L,MECOM,POLR1E,SPATS2L,PDZD2,GPAM,AFF3,KIF7,HNRNPH1,LYN,PROCR,SOX9,MXRA5,FAM136A,ARSD,ANKMY1,ZFPM1,AP1B1,GPC3,CEP104,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,CPNE1,TEK,CXCL8,ADAMTS1,MAPK8IP2,RIMS4,LZTR1,ERCC2,UBL4A,KANK1,BCL2L1,ZNF296,H3F3A/H3F3B,SLC7A2,C19orf54,BAP1,NAGLU,C17orf97,SULF1,FEM1A,ZP3,FLRT1,ZNF252P,GIMAP6,INPPL1,DHCR7,EDN1,GTPBP2,ERBB2,THBS4,NDUFV1,PLAUR,PYGB,FRMD4A,SAA2,ORAOV1,POLR3B,COL11A1,ING1,CXCL2,FCGBP,PRUNE2,KCND2,DDX11,BMP4,CTGF,TYRO3,MST1,GYG2,POMC,HOMER3,EIF6,SGPL1,ITGA3,PRG4,MTUS1,PNKD,TESK1,PPIL6,CAPN5,EFL1,PIK3C2B,TMEM37,NAB1,PLEC,HMGA1,CHI3L2,THBD,FAM86B1,ACAD11,CORO7/CORO7-PAM16,MAP3K12,CCZ1/CCZ1B,CCT3,AKR1C4,NOTCH1,NRP1,SORL1,SUSD2,AKAP12,CNN2,MAP7,FCGRT,GSTM5,SIN3B,TTLL4,ATAT1,GPC4,RCOR2,TMEM259,MEOX2,THBS3,SF3B3,TIGD5,ENAH,RPUSD3,CES1,CCL8,CD24,EGFL6,AHNAK2,RBBP9,CEP164,MYOM2,TRIM28,EGR1,DAAM1,BHLHE22,ARHGAP4,AXL,RELN,YIF1B,GABRE,RBM42,BRINP2,CILP,PTGS2,ZFYVE19,TM4SF1,TFF3,FARP1,UNC5B,MAP1B,ZNF91,COMT,NMNAT2,RET,PHACTR3,MFSD3,FUCA1,TRIOBP,GSDMB,USP36,SLC4A7,TPSAB1/TPSB2,UBXN11,FLCN,SORD,LRRC41,RAP1GAP,N6AMT1,FRYL,SCRIB,AMY1C (includes others),ATF5,SLC4A11,TBCB,PTPRF,THBS1,KIAA0040,ARHGEF35,CFB,ASAP3,NCL,CHEK2,RHBDD3,EMILIN1,TPST2,PCOLCE2,LRRK2,RPS21,CCDC85A,LOC401052,EBF1,PLEKHH1,FAM46A,CPZ,KDR,XK,CSTA,HCAR3,HLA-DOA,ANKRD35,PAPLN,SVEP1,ANKRD20A4 (includes others),ASCC2,CLIP1,FADS3,NSF,GNA15,NUP93,CTSH,RAB38,KEAP1,MGP,CEP170B,KANK3,DLG4,KAT2A,SLCO2B1,TSHZ2,TM6SF1,FAM189B,DPT,MTSS1,MFAP5,TNFRSF10B,LAMC3,IFNAR2,HAX1,SHROOM4,WDR81,EVPL,MN1,CTSA,SAMD4A,PTPRA,ZNF205,C9orf24,SEMA6A,CDK4,CTHRC1,ZBTB9,CKAP4,TECR,HS3ST3A1,SDHAF1,TGM2,ARFGAP1,HCAR2,RAD21,FCGR3A/FCGR3B,FCER2,MAPKAP1,SPRY1,MLF2,MRPS25,GRN,FAM178B,ARHGEF5,FLNC,ATP1A2,TAGLN,TAF1C,AARS2,TTYH3,ABCC3,ABCB6,FOXRED1,AMDHD2,SLC38A10,PTTG1,RTN1,HSPA1A/HSPA1B,ACO2,ABCG1,TGFBR2,GPR4,CXCL14,ZNF598,GYPE,CHTF18,LRBA,FMO2,RILPL1,CLIP2,THRA,ANO1,DCHS1,KLF4,CYB561,GZMH,TRIM39,ORM1,MATN2,APCDD1,LIMA1,SORCS2,THAP7,IGFBP3,RUNX1,POLR3F,SPIRE2,SF3B5,MECR,DENND4B,ABCF1,NUDT2,NEURL4,SLC2A3,RPL14,SHC1,CCDC107,HLA-DRB1,AHNAK,TIMP1,SAA1,MEX3B,LOC102724428/SIK1,HES4,TOX2,VARS,GJA4,C4BPB,CTAGE9 (includes others),APBB1IP,SLC12A2,TUBG1,PGAP2,GATSL3,ATIC,SH3PXD2A,CLGN,TACC2,PHF19,CDC34,GAPVD1,ZNF404,PNPLA6,COQ9,NNAT,KCNK15,TRAP1,HRAS,NCSTN,PCDH7,GRWD1,SATB2,MFAP2,NCOA7,PEX16,CLCNKA,NPTX2,SLC16A2,ANK2,IRS2,EYA2,PEX6,PCSK5,RRBP1,TUBB2A,MMP2,CRABP1,SERINC2,SRGAP3,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,MAP2K3,MAPK7,ZER1,AIDA,CYR61,PDGFD,MYEOV,BOD1,SPTBN1,HIST1H1C,EMILIN2,PSMB10,TNFSF10,FOLR2,KAZN,PFKL,IDH1,EFNB2,MTOR,SRGAP1,SLC2A6,PRKCE,TPO,COL18A1,PTPRT,SF3A2,PTK7,GSTM1,VPS18,TWNK,TYROBP,DPAGT1,CYP1B1,B4GALT2,F11R,COL5A3,RHPN2,FAM86C1,CLDN5,S100A9,CNN1,SPRY2,S1PR1,ALS2CL,CBX4,SYN2,C16orf89,CYP2C8,PHLDA1,SERPINI1,SPHK2,CXCL12,LIPE,TPM1,MTCH2,CYP26B1,CEL,TNIP1,ITGA11,ASXL2,LTBR,PDK4,IGFBP6,AXIN2,TMIE,SPP1,MACROD1,PCSK7,LMNA,SNRK,FOXC1,DPP9,PPP2R1A,C9orf9,CORO1B,PKD1,SLC22A5,ACOT4,LSM7,PLEKHH3,THSD7B,AK2,AOC3,ADAMTS7,NFIX,ERN1,CHPF,PKM,PPP1CB,SMPD1,ITGA10,PRKCSH,SOX17,EPHB6,ADSL,TMEM119,PCK2,CSPG4,SRGN,KIT,ARHGEF2,NR2F6,PTGER4,TMEM132B,SNAPC4,CXCR4,COPS7A,SMAD7,CSF1R,NDUFA13,TRMT61A,LPAR1,LRP1B,ZNF585A,EPB41L2,DSG2,MMP9	510	
Carbohydrate Metabolism, Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of phosphatidic acid	2.75E-06	 	0.307	 	-0.836	APOE,SFTPD,SCAP,LEP,CD36,ABCA3,VAC14,TNFSF10,HRAS,SMPD1,INPPL1,ABCG1,HIF1A,NGF,CEL,HINT1,MTOR,ACP6,ANXA5,SPTLC2,CAV1,ENPP2,LIPG,PI4KA,PI4KB,TEK,MBOAT7,CERS6,CXCL8,ABHD5,FMO3,SPP1,FIG4,BRMS1,BSCL2,THRSP,SLC3A2,PLA2G4A,GPAM,LDLR,DGKQ,PIP5K1C,FCER1G,CD14,ACACA,PTGS2,PNPLA6	47	
Cellular Function and Maintenance	function	function of antigen presenting cells	2.97E-06	 	 	 	 	RGS1,CD36,UNC5B,TYRO3,PLA2G15,CXCL12,FCER1A,MST1,IL6,GPNMB,IDUA,LGMN,PLA2G5,CAV1,CLCN3,BIRC3,MARCO,CMKLR1,SPP1,DOK2,CAPG,NLRX1,APBA3,CARD9,ITGAM,CD14,IDO1,CNN2,FYN,APOE,SFTPD,GADD45B,ZFP36,GDF15,IRAK1,MCOLN1,MTOR,NFKBIA,CCL2,CSPG4,RASSF5,PTGER4,PLAT,RHBDD3,FCER2,CCR1,CD209,SIGMAR1,PLXNA1,NLRP3,UCP2,TYROBP,EGR1,PLAUR,AXL,CSF1R,GRN,BTK,FOS,ARHGEF5,F11R,PLA2G4A,LY96,RRAS2,WAS,LYN,FCER1G,PTGS2,KDR,P2RX7,MMP9	71	
Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Tissue Development	morphology	morphology of ventricular septum	3.02E-06	 	 	 	 	ADM,APOE,ADAM17,ADRBK1,ABL1,HIF1A,IL6,ATP2A2,BIN1,IDUA,CCND3,THBS1,CAV1,LY6E,CASQ2,HEY1,HEYL,DHRS3,VCAM1,SGCG,CXCR4,IGF2R,CCND2,NTRK3,TXNRD2,MMP9	26	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of macrophages	3.03E-06	 	 	 	 	CD36,UNC5B,TYRO3,PLA2G15,CXCL12,FCER1A,MST1,IL6,IDUA,LGMN,PLA2G5,CAV1,CLCN3,BIRC3,MARCO,SPP1,DOK2,CAPG,NLRX1,APBA3,CARD9,ITGAM,CD14,CNN2,FYN,APOE,SFTPD,ZFP36,GDF15,IRAK1,MCOLN1,NFKBIA,CCL2,CSPG4,PTGER4,FCER2,PLAT,CCR1,SIGMAR1,UCP2,NLRP3,TYROBP,EGR1,PLAUR,AXL,CSF1R,GRN,PLA2G4A,FOS,LY96,LYN,FCER1G,PTGS2,P2RX7	54	
Carbohydrate Metabolism	synthesis	synthesis of glycogen	3.04E-06	Decreased	-2.186	 	-2.489	NNAT,SOCS3,GFPT1,LEP,ADRBK1,LEPR,CD36,PPP1R3C,PPP1CB,INPPL1,IL6,MTOR,PPP1R3F,GYS1,SORBS1,IRS2,GSK3B,ERBB2,ACADM,ADRA1B,ABHD5,APLNR,H6PD,CSF1R,GPAM,ZFPM2,NR1D1,NTRK3,IGFBP3,GBE1	30	
Cell Cycle	interphase	interphase of tumor cell lines	3.12E-06	 	1.255	 	0.707	CAMK1,SGK1,RRM2B,HRAS,IL6,SPI1,MIA,CCND3,CSE1L,SMARCB1,NABP2,KAT2A,ETS1,BIRC7,CDKN1C,NDRG1,SLX4,RPA1,HMGA1,CCND2,BTG2,TFRC,MAP2K3,CYR61,PTPRA,NOTCH1,mir-21,DDIT3,OSGIN1,FGF2,GDF15,ADIPOQ,CDK4,CEBPD,DTD1,SYNM,MTOR,RABL6,JUN,GADD45A,DAB2,PRKCE,VPS18,MGMT,AXL,ID3,CYP1B1,TF,SPRY2,NR5A2,TP53BP1,SOX9,PIN1,ADRA1A,PRPF19,SPHK2,MTCH2,MYC,CEL,GSPT1,PDCD6,EPB41L1,NOX4,SPP1,GPS2,KLF4,FAAP20,CCNG2,ERCC1,CBX1,PKD1,TRIM39,DUSP1,BAP1,GNL3,ESR1,VHL,PMEPA1,SULF1,LEP,ATF5,BMP2,RBBP8,ABL1,NGF,CDKN2B,HLA-G,SHC1,HMOX1,NFKBIA,NET1,KIT,ERBB2,CHEK2,PRNP,SRC,TAF6,HYAL1,PLAUR,MT1A,RBCK1,NEK11,CAT,MMP9	104	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	necrosis	necrosis of kidney	3.15E-06	 	-1.607	 	-2.432	GFPT1,CTGF,MST1,HRAS,APRT,SGPL1,MCOLN3,ABCC1,ZHX2,HIPK2,MCL1,PTGIS,ATG7,COMP,TNFRSF10B,IER3,HAX1,PPP1R15A,TFRC,GAPDH,SFRP1,mir-21,FYN,APOE,GSTM5,DDIT3,FGF2,HYOU1,TNFSF10,CASP4,DAP3,RASSF5,ADORA1,NDUFAB1,RAD21,ATN1,PLAT,EMP3,TRIB3,SRXN1,PLA2G4A,FOS,MYOC,NTRK3,PEA15,LYN,BNIP3L,MAP3K8,PTGS2,RFXANK,ADRBK1,CA4,UNC5B,HSPA1A/HSPA1B,HSPA5,MYC,IKBKG,NEO1,GSK3B,BIRC3,HK1,SPP1,ATF3,TJP2,UNC13B,GNG2,PAWR,PTGDS,BCL2L1,NOL3,PKD1,TRIM39,DUSP1,PRKCD,IGFBP3,IDO1,ALDH3B1,ESR1,RBP4,ERN1,ATF6,HIF1A,IRF3,HMOX1,NFKBIA,EDN1,STUB1,ERBB2,ATP13A2,AGT,PRNP,NLRP3,AQP11,SMAD7,PRMT1,SLK,EMP1,PMP22,CAT,TNFRSF19,SLC47A1,P2RX7	102	
Cell Death and Survival	cell death	cell death of immune cells	3.15E-06	 	1.632	 	0.999	APOB,BMP4,RAN,ELANE,HRAS,SH3GLB1,SERPINA3,C1QA,IL6,SPI1,HOXA9,NR4A3,ABCC1,CAV1,DNAJA3,IRS2,EYA2,MCL1,ETS1,TNFRSF21,DDIT4,STOML2,IER3,HAX1,HLA-DRB4,CCND2,NCF2,CTSB,GAPDH,CD86,MAP2K3,MAPK7,NOTCH1,FTH1,APOE,HIST1H1C,FYN,NME1,ADAM17,GADD45B,DDIT3,DAPK2,LEPR,FGF2,NQO2,TNFSF10,CASP4,MCTS1,MYH11,EIF4EBP1,DIABLO,TGM2,MTOR,LYZ,JUN,CCL2,CST3,CSF2RA,PRKCE,PIK3R2,PCBP2,HCAR2,FCGR3A/FCGR3B,PLAT,TYROBP,EGR1,CD69,ST3GAL3,ID3,FOS,GPAM,PLA2G4A,LDLR,SWAP70,WAS,BMF,LYN,FCER1G,MS4A2,PIN1,TNFRSF4,LAMTOR2,CD4,HAVCR2,POLR3E,FCER1A,CXCL12,ABCG1,TUBB,MYC,TGFBR2,CTSD,IKBKG,PLCE1,ETS2,COMT,GIMAP5,GSK3B,CCDC86,LTBR,CAST,BIRC3,KLF2,HK1,CXCL8,MIF,ATF3,SPP1,ITPR2,EGR3,BTG1,PAWR,KLF4,PKN1,TPSAB1/TPSB2,BCL2L1,ITGAM,PRKCD,IDO1,CD14,ESR1,MAP2K5,VHL,RUNX1,SFTPD,LEP,ERN1,BMP2,TPR,ANTXR1,ABL1,TNFAIP3,SMPD1,IRF3,HIF1A,NGF,CCL3,ETV6,IRAK1,HLA-G,HMOX1,SHC1,NFKBIA,STUB1,TIMP1,THBS1,DKK3,CLOCK,KIT,S100A8,ERBB2,HCST,CUL9,CHEK2,PTGER4,CD59,NLRP3,CXCR4,NQO1,SMAD6,SMAD7,PERP,CSF1R,FAIM,BTK,COL1A1,RCAN1,EBF1,VAV3,CAT,ACAT1,CXCL2,RCAN2,P2RX7,CLEC10A	175	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of phagocytes	3.15E-06	 	-0.864	bias	-3.864	RARRES2,PFN1,CD4,SPHK2,ELANE,CTSG,CXCL12,MST1,SERPINA3,SPI1,HOXA9,RHOB,CXCL14,VEGFD,C1QBP,MARCO,CSF3R,ELN,CXCL8,MIF,CMKLR1,SELE,SPP1,PLEC,VEGFC,ANO6,FLOT1,CAPG,NINJ1,TPSAB1/TPSB2,AQP9,ITGAM,PIP5K1C,ITGA1,MDK,APOE,FYN,SFTPD,LITAF,DAPK2,NGF,CCL3,G6PC3,CCL3L1,EDN1,CCL8,CCL2,CCL3L3,THBS1,CST3,CSF2RA,SAA1,S100A8,STIM1,ERBB2,LBP,MAPKAPK2,ADORA1,HCAR2,PRNP,CCR1,THBS4,C5AR1,MMP28,ANGPT1,CXCR4,CD69,LRRK2,PLAUR,DEFB1,SLIT2,CSF1R,GRN,HP,SWAP70,LDLR,S100A9,WAS,VAV3,LSP1,LYN,FCER1G,EDNRA,CXCL2,NCKAP1L	85	
Infectious Diseases	replication	replication of RNA virus	3.17E-06	Increased	3.099	 	0.818	EIF3C,AHCYL1,SGK1,HRAS,IL6,SGPL1,SP110,ITGA3,CSE1L,SMARCB1,MARCH2,CAV1,ATF4,DMAP1,ATG7,FANCG,GRK5,TNK2,NLRX1,IFNAR2,UBQLN4,RAE1,NRBP1,MAP3K12,PIP5K1C,FSCN1,PPP1R15A,APOBEC3C,MAP2K3,mir-21,ATP6V0B,EIF4EBP2,GBP1,DAPK2,CDK4,TNFSF10,TBL3,DCLK1,ATP6AP1,IFI27,DDX3X,EIF4EBP1,EFNB2,DCLK2,MTOR,JUN,CCL3L1,CCL3L3,CST3,ANXA5,SNX10,SOCS2,LY6E,PSMD14,PIK3R2,PCBP2,PI4KA,CCR1,CD209,SIGMAR1,MED30,SLIT2,F11R,LAMP2,RBM42,S100A9,ATP1A2,MAN2B1,PIN1,CH25H,SOCS3,CD4,HAVCR2,RABEP1,CXCL12,TUBB,MYC,CEL,MAP2K2,GABARAPL1,AMPH,STAB1,MID1IP1,GSK3B,VNN2,TRIM5,ADRA1B,FERMT3,PTX3,CXCL8,SPP1,STK39,PCSK7,POLR2H,AGTRAP,GPR146,BCL2L1,CDC42BPB,PKD1,PRKCD,RARRES3,XPNPEP1,ESR1,KATNB1,MAP2K5,RUNX1,SFTPD,ERN1,PTPMT1,ABL1,IRF3,NAA10,NGF,CCL3,EPHB6,HMOX1,NFKBIA,S100A8,SULF2,NCL,LONP1,PRNP,AP2M1,EPAS1,APBB1IP,ATP2C1,CXCR4,EXOSC5,F13A1,TRMT61A,UBE2E2,MAP4K4,P2RX7,ISG20,ATP6V1B2,MMP9	136	
Cell Death and Survival	apoptosis	apoptosis of carcinoma cell lines	3.17E-06	 	-1.474	 	-1.374	ACO2,KLF6,TRAP1,CXCL12,CDKN2C,SERPINA3,IL6,DNAJC15,HSPA5,AP2A2,MYC,SATB2,RHOB,MTUS1,ETS2,ABCC1,GSK3B,RET,KLF2,MCL1,CERS6,IGFBP6,ATG7,SPP1,NDRG1,PPP1R1B,TNFRSF10B,THY1,PAWR,HMGA1,RASD1,TXNRD1,BCL2L1,TRIM39,DUSP1,PRKCD,IGFBP3,CTSB,BAP1,GAPDH,SFRP1,MDK,NOTCH1,mir-21,PMEPA1,SULF1,DDIT3,OSGIN1,FGF2,PKM,ADIPOQ,TNFSF10,ATF6,HIF1A,PDCD4,UCHL1,TGM2,HMOX1,MTOR,NFKBIA,PRKCE,STIM1,SEMA3B,CHEK2,SRC,EPAS1,ID3,GRN,HNRNPH1,SPRY2,PEA15,ING1,PTGS2	73	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	lysosomal storage disease	lysosomal storage disease	3.23E-06	Decreased	-2.247	bias	-1.157	APOE,SGSH,CD36,HEXA,SMPD1,IL6,GUSB,NEU1,IDUA,CTSD,MCOLN1,CD55,GBA,GLB1,ALDH3A2,CAV1,ATP13A2,FUCA1,ABHD5,ACP2,GM2A,HYAL1,LRRK2,ARSA,S1PR3,GRN,CTSA,CD14,NAGLU,TPP1,CLCN7,CCL18	32	
Cancer, Organismal Injury and Abnormalities	neoplasia	neoplasia of tumor cell lines	3.34E-06	 	0.098	 	-1.288	BMP4,DNAJB4,PTTG1,TGFBR3,KLF6,TYRO3,IL6,MYC,TGFBR2,ITGA3,ADGRF5,MTUS1,CSE1L,TSC2,CAV1,PDK4,MATK,ETS1,CXCL8,NOX4,ATF3,NDRG1,ADAMTS1,THY1,VEGFC,ZNF282,FLOT1,THRA,SNRK,TRIM35,MBD2,TNK2,THBD,ROR1,KLF4,UBL4A,SH3GL1,CDH2,SDCBP,FSCN1,PRKCD,FAM26F,BAP1,CTSB,ALCAM,CAPN2,MAP2K3,CYR61,ANG,mir-21,FYN,NME1,ADAM17,RALA,FGF2,HCAR1,PKM,HMOX1,NFKBIA,ANGPTL4,CCL8,CCL2,THBS1,ALDH1A3,MCAM,CD24,ENPP2,STIM1,ERBB2,COL18A1,PRNP,NDUFAF3,PAK4,EPAS1,CXCR4,EGR1,MGMT,PLAUR,SERTAD1,NDUFA13,FOS,FAF1,WAS,CNN1,GPBAR1,SPRY2,VAV3,PROCR,SOX9,PTGS2,CXCL2,NEDD9,MMP9	93	
Cellular Movement	migration	migration of breast cancer cell lines	3.47E-06	 	0.121	 	-1.694	CTGF,TGFBR3,SPHK2,CXCL12,HRAS,IL6,SDC4,MYC,ADGRF5,MTUS1,CSE1L,CAV1,DNAJA3,KPNA2,MATK,ETS1,CXCL8,SPP1,ATF3,NDRG1,MMP2,TNK2,ROR1,FOXC1,KLF4,CDH2,SDCBP,RAP1GAP,GIPC1,PRKCD,IGFBP3,CAPN2,RSU1,DNAJB6,ESR1,UBE2I,NRP1,TNFAIP8,NME1,LEP,OSGIN1,FGF2,BMP2,GNA11,RUVBL1,HIF1A,ENAH,GRINA,TGM2,ID1,SHC1,MTOR,JUN,CCL2,NET1,TIMP1,FLNA,MCAM,ACSL4,ERBB2,ADRB2,NDUFAF3,PLXNA1,SRC,BHLHE41,CXCR4,PLAUR,AXL,FAF1,KRT8,WBP2,BMP6,MAP4K4,MMP9	74	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	cell death	cell death of kidney cells	3.53E-06	 	-1.590	 	-2.664	GFPT1,CTGF,MST1,HRAS,SGPL1,MCOLN3,ABCC1,ZHX2,HIPK2,MCL1,PTGIS,ATG7,COMP,TNFRSF10B,IER3,HAX1,PPP1R15A,TFRC,GAPDH,SFRP1,mir-21,FYN,APOE,GSTM5,DDIT3,FGF2,HYOU1,TNFSF10,CASP4,DAP3,RASSF5,ADORA1,NDUFAB1,ATN1,RAD21,EMP3,TRIB3,SRXN1,PLA2G4A,FOS,MYOC,NTRK3,PEA15,LYN,BNIP3L,MAP3K8,PTGS2,RFXANK,ADRBK1,CA4,UNC5B,HSPA1A/HSPA1B,HSPA5,MYC,IKBKG,NEO1,GSK3B,BIRC3,HK1,SPP1,ATF3,TJP2,UNC13B,GNG2,PAWR,PTGDS,BCL2L1,NOL3,PKD1,TRIM39,DUSP1,PRKCD,IGFBP3,ALDH3B1,ESR1,RBP4,ERN1,ATF6,HIF1A,IRF3,NFKBIA,EDN1,STUB1,ERBB2,ATP13A2,AGT,PRNP,NLRP3,AQP11,SMAD7,PRMT1,SLK,EMP1,PMP22,CAT,TNFRSF19,SLC47A1,P2RX7	98	
Cellular Movement	migration	migration of connective tissue cells	3.54E-06	 	-0.342	 	-1.873	CTGF,ITGB1BP1,IL6,SDC4,MYC,TGFBR2,SGPL1,CAV1,ELN,MIF,CALCRL,DPT,SPP1,TMEM201,PLEC,HBEGF,S1PR3,PRKCD,LIMA1,RAMP3,CYR61,PDGFD,PTPRA,TNS1,mir-21,COL7A1,APOE,SLC4A2,LEP,FGF2,BMP2,ADIPOQ,ABL1,CCL3,RAMP2,EDN1,CCL2,KCNMA1,RHOD,THBS1,SMO,CYGB,PRKCE,MAPKAPK2,LPP,AGT,SRC,ANGPT1,ARHGAP4,PLAUR,CSF1R,COL1A1,CXCL16,CAPNS1,S1PR1,MAP3K8	56	
Cell Morphology	abnormal morphology	abnormal morphology of cells	3.69E-06	 	 	 	 	SYTL2,CACNA1H,COL8A1,C1QA,SERPINA3,IL6,SPI1,ATP2A2,TYSND1,IDUA,CCND3,GLB1,LUM,CAV1,ATF4,NABP2,PLXNB2,EBF2,AMHR2,CASQ2,ETS1,RBM38,CLEC4G,SELE,DPT,CIDEC,ANO6,HAX1,PYGO2,TMEM127,DVL2,IFT122,CTSA,NPR3,PPP1R15A,CTSB,TFRC,CD86,ITGA1,PTPRA,APOE,SLC4A2,EIF4EBP2,FGF2,CEBPD,CDK4,ADIPOQ,CTHRC1,HEXA,COL15A1,DTNA,GADD45A,PLIN2,POMGNT2,HEY1,TSTA3,MECOM,ZNF521,DGAT2,GFRA2,GPM6B,AGL,TK2,ID3,CSTB,GRN,PLA2G4A,LDLR,CBS/CBSL,NTRK3,FLNC,LYN,TPP1,ARHGDIA,SOX9,MAN2B1,PTTG1,ABCA3,MBP,ZFPM1,ABCG1,TYMP,BIN1,PNRC2,TGFBR2,HSPA4,ADGRF5,CHTF18,CAST,TEK,ATF3,GM2A,LAMA2,MAPK8IP2,UNC13B,H6PD,SGCB,THRA,ARSA,STX1A,OGN,H3F3A/H3F3B,DUSP1,ALDH1A2,IGFBP3,NAGLU,PSME4,MDK,ESR1,SYN1,RBP4,SUN1,ETV5,SULF1,IGFBP4,LOX,SRPX,ZP3,CLUAP1,CADPS2,EMX2,GLRX,CIAPIN1,HLA-G,MSRB3,SHC1,STUB1,ERBB2,ATP13A2,NUSAP1,NLRP3,SLC12A2,TUBG1,UPP1,EMD,PLAUR,BSCL2,KIF3B,ZPR1,SERPINE2,RCAN1,PMP22,ACADVL,KIF5B,VAV3,HEPACAM,LPAR5,SPARC,AP3M2,DNM1L,KCND2,CTGF,ITSN1,SNTA1,CDKN2C,MST1,EIF6,HOXA9,MIA,ITGA3,SLC4A3,PEG10,LGMN,ABR,GAA,RARA,IRS2,HEY2,HADHA,WNT5B,MCL1,RASL10B,ATG7,NAB1,ZC3HC1,PLEC,HBEGF,IER3,HMGA1,PLOD1,S1PR3,SH3GL1,CDH2,CCND2,CD68,EPB42,LRP8,MAPK7,CAPRIN1,SAC3D1,COL3A1,ADM,SORL1,CNN2,SPTBN1,FYN,ADAM17,TCEA1,PSMB10,SIN3B,SLC1A3,ATAT1,MYH11,DCLK1,VTI1B,VCAN,COL5A1,TRIB1,MCOLN1,JUN,PDE3B,COL18A1,NCKIPSD,PLOD3,IL11RA,MBOAT7,CYP11A1,CTSK,ABHD5,TYROBP,IMPDH2,EGR1,COL12A1,YBX2,LAMP2,KRT8,WAS,SBF1,BMF,SPRY2,FCER1G,PEA15,BNIP3L,ARID4A,SYN2,FAT1,CD36,CD4,MAP1B,MNS1,CLIP3,CYP26B1,IKBKG,CAMK2D,BRSK1,PRND,AMPH,IP6K1,GSK3B,CCDC86,LTBR,RET,FBXO45,CLCN3,KLF2,ACTA1,ADRA1B,PDK4,EIF2AK1,TTYH1,MIF,FST,LMO4,ACP2,ITPR2,EGR3,TALDO1,LMNA,SLC4A7,MAPK8IP3,ERCC1,PKD1,PRKCD,RGN,IDO1,CLCN7,--,EPB41L3,ERN1,SLC4A11,ABL1,CDH23,SLC7A1,SMPD1,ELOVL3,GPR34,NGF,CDKN2B,PTPRF,AEBP1,MAN2C1,CD55,NFKBIA,THBS1,RPS6KB2,SULF2,HMGCL,ALPL,ACADM,CTDNEP1,ADRB2,ZFP42,CD59,COL5A2,PAK4,EPAS1,ATP2C1,CXCR4,MTMR14,HYAL1,LRRK2,NFKBIZ,CSF1R,KIF2A,EBF1,ITPA,CYTIP,LPAR1,EPHB3,GAP43,XK,RCAN2,MMP9	323	
Cellular Growth and Proliferation	cytostasis	cytostasis	3.77E-06	 	0.186	 	-1.274	SOCS3,BMP4,ADRBK1,HSPA1A/HSPA1B,PARP2,KLF6,HRAS,CDKN2C,IL6,SPI1,METAP2,MYC,TGFBR2,PADI4,CCND3,RARA,ABCC1,CXCL14,TSC2,SMARCB1,CAV1,GSK3B,ETS1,SFRP4,MIF,RERG,TNFRSF10B,PLAG1,TIMP4,CDH5,PPP1R15A,BAP1,RSU1,CRABP2,CYR61,PIDD1,ESR1,PTPRA,NOTCH1,mir-21,UBE2I,INO80B,SULF1,FYN,NME1,EPB41L3,BMP2,ABL1,CDK4,ATAT1,NGF,CCL3,ETV6,ID1,NFKBIA,JUN,TIMP1,RHOD,SLC19A1,KIT,CD24,ERBB2,CSNK2B,COL18A1,ADORA1,CHEK2,LXN,MYCN,SRC,UBE2M,MECOM,EGR1,NQO1,SMAD7,PRMT1,RRAS2,CBS/CBSL,NTRK3,ING1,ABCC3,BMP6	81	
Cancer, Organismal Injury and Abnormalities	breast or ovarian carcinoma	breast or ovarian carcinoma	3.85E-06	 	-0.160	 	-0.026	PCLO,VAC14,PAQR7,NPAS2,POR,CCND3,EIF3B,AJUBA,PPRC1,MAP1A,AMHR2,ETS1,FBL,PTGIS,SRPRA,SLX4,PTOV1,C14orf79,SLC27A1,RAB40C,mir-21,EPHX1,LTBP2,COL15A1,DDX3X,SYNM,DTNA,RABL6,TIPARP,GTF3C1,MECOM,KIAA1549L,CDO1,IGF2R,PAMR1,PDZD2,AFF3,KIF7,SWAP70,TBC1D8,WBP2,SOX9,LIG1,AKR1C3,MICALL2,RGCC,TRPM8,FCER1A,AP1B1,CTSD,CARD8,NDUFA10,TUBA1C,CXCL8,TJP2,ADAMTS1,GNAZ,ERCC2,TXNRD1,BCL2L1,CRHBP,BAP1,C17orf97,SLC11A1,RAB11FIP5,SULF1,IGFBP4,FEM1A,ZP3,PLGRKT,CLUAP1,INPPL1,COL6A6,PHLDB2,HLA-G,ALDH2,F8,IGSF8,ERBB2,SRC,PATL1,NLRP3,FRMD4A,ANO3,COL11A1,ING1,CERCAM,KCND2,EIF3C,DDX11,ASPSCR1,BMP4,GMDS,CMTM4,TYRO3,PCDH17,GYG2,ACP5,EVI5L,ITGA3,PRG4,IRX3,MGAT4B,PIK3C2B,EFL1,CMKLR1,CAPN6,MT1X,PLEC,FAHD2A,HBEGF,ATP8B4,TMEM267,PARP3,CREB5,NLRX1,RNASEH2A,FAHD2B,FARSA,SH3GL1,MS4A14,DPH2,ACAD11,MAP3K12,EEF2KMT,PDE1B,NCLN,RTN4,NOTCH1,NRP1,COL3A1,SORL1,RP9,GSTM5,CRTAP,HEATR1,SIN3B,FKBP1A,ATAT1,FAM174B,CORO2B,THBS3,H2AFZ,C20orf96,STOM,NDUFB9,CES1,ZNF334,PDE3B,ZNF608,ENTPD6,DIP2B,TUB,COL22A1,CD24,EGFL6,NPTXR,FUK,AHNAK2,LIMCH1,PLXNA1,CD276,CEP164,STAMBPL1,MYOM2,EGR1,WDR55,COL12A1,LRSAM1,NBEA,SLIT2,NTM,AXL,COPS3,PTGS2,ATAD3A,FBXW9,MAMSTR,ZFYVE19,TM4SF1,COBLL1,LRFN4,FARP1,FAT1,CD4,CLIP3,CLEC3B,LHCGR,FAM173A,H2AFY2,WDR5,GSPT1,ETS2,BCL7C,DHTKD1,COMT,MCTP1,AMPH,PGP,GSK3B,C1QBP,KLHDC3,HK1,MT1G,PTPRE,GSDMB,EGR3,PCDHA1,MAPK8IP3,ANKRD33,SORD,COL6A3,SCRIB,ATF5,SLC4A11,PTPRF,SSU72,ARHGAP17,THBS1,HSPE1,GOT2,NCL,MAPKAPK2,CHEK2,ADRB2,BEX2,TMEM104,EPAS1,TPST2,C9orf3,LRRK2,TANC2,CCDC85A,DHX37,CIART,C2orf88,PLEKHH1,CYC1,PLP2,MT1F,EPHB3,GPR160,C6,CLEC10A,NIPA2,HCAR3,SYTL2,MAP6,CACNA1H,COL8A1,MT1E,CLIP1,ODC1,FADS3,OGFOD3,ZNF263,IP6K3,EGR2,NUP93,CYBA,KEAP1,IQCC,ARHGAP39,KANK3,MGP,CAV1,ATF4,SPATA18,PIGT,RNF121,TSHZ2,MRPL24,PDIA5,SOGA1,MFAP5,PPP1R1B,SMG5,MASP1,FLOT1,LAMC3,BRF2,TFPI2,MAMDC2,GPX7,HAX1,SHROOM4,NRBP1,TMEM127,TNPO2,EVPL,NRDE2,CTSA,FSCN1,VARS2,ITGA1,IGSF10,SAMD4A,APOE,FBXO10,NACC2,CUBN,SCUBE2,CDK4,CTDSPL,KLHDC9,COL16A1,TGM2,DUSP5,CS,CCL2,SORBS1,DAB2,FAM96B,ADORA1,HCAR2,TBC1D10B,RAD21,MED20,NINL,CUL7,MRPL12,NLGN4X,TRIB3,GPM6B,AGL,C1orf122,HSPA2,FAM178B,FOS,NRXN2,ZFPM2,NR4A2,LDLR,TAGLN,TMEM106C,SLC22A18,MAP3K8,C19orf12,SEMA3C,ABCC3,CPXM1,HAGH,ISM1,MT2A,ATP13A1,ABCA3,PARP2,STARD7,CES2,MYC,TGFBR2,GPX3,GPR4,MAP2K2,HDAC11,CXCL14,FAR2,STAB1,PDCD6,LILRB5,CAST,FMO4,PFKFB3,PKP2,MAST4,GM2A,LAMA2,VEGFC,DCHS1,KLF4,TLN2,ABCA8,GIPC1,APCDD1,ALDH1A2,LIMA1,IGFBP3,DNAJB6,MEGF8,ESR1,LRRC47,DPH5,PMEPA1,MAST2,RUNX1,ERAP2,FAM107A,ZSWIM3,TPR,ABCF1,GCDH,RAP1GDS1,POLR1C,MSRB3,SHC1,MCAM,MKL2,LOC102724428/SIK1,ENPP2,LRPPRC,VARS,MCRS1,AGT,NUSAP1,PARVA,C4BPB,TUBG1,EMD,GATSL3,LARP6,BSCL2,PNCK,NFE2L1,ATIC,SH3PXD2A,XYLT2,PMP22,TACC2,VAV3,LPAR5,ALKBH3,APOB,ITSN1,TGFBR3,HRAS,CDKN2C,RAPH1,GTF2IRD1,PCOLCE,SLC4A3,PEX16,CLCNKA,ABR,ZHX2,ANK2,VEGFD,CSTF2,IRS2,RRBP1,TUBB2A,MMP2,IER3,TNK2,UBQLN4,RAE1,COLEC12,CDH2,SRGAP3,TIMP4,ASGR1,MS4A4A,MAP3K20,ADAMTS18,MS4A7,SPINT2,ALDOA,TRO,HSPB7,LRP8,ZER1,CYR61,MYEOV,SPTBN1,HIST2H2AA3/HIST2H2AA4,HIST1H1C,ADAM17,PIGO,GRB14,NID2,CHCHD6,WASF3,UHRF1BP1,XPOT,PFKL,TTC1,MYH11,KHDC1,DCLK1,VCAN,TMEM94,IDH1,FANCE,COL5A1,MTOR,CMTM8,CLMN,TPO,TBCD,PCBP2,PTPRT,PLOD3,CYP11A1,VPS18,ANGPT1,DPAGT1,MVB12A,COL5A3,PLEKHG6,CDK20,IPO13,CNN1,MS4A2,DVL3,MAPRE3,CYP2C8,FBN2,PHLDA1,SPHK2,PLA2G15,XPO5,CXCL12,UTP4,TPM1,ARG2,TUBB,COBL,ASXL2,BRSK1,MYO10,ACTA1,AGBL5,PDK4,CSF3R,AXIN2,SPP1,MYOF,MARS,PKN1,PPP2R1A,ERCC1,PKD1,SMOX,THSD7B,AKR1B1,RNPEP,COL7A1,ADAMTS7,EPB41L3,FLRT2,CUTA,BCL2L12,PKM,ABL1,RBBP8,SLC7A1,TET1,TNFAIP3,MYLK,ITGA10,FAM110B,EVC,COL1A2,EPHB6,AEBP1,PCK2,CSPG4,FUBP3,CLOCK,KIT,HIST2H2AC,NEK7,RNF144B,CUL9,STK40,HMGCS1,PI4KB,PRRT3,RAB11FIP3,SNAPC4,SPOCD1,LCLAT1,VWCE,SMAD7,ZBTB7C,ITPA,EXOC4,DIP2C,LPAR1,RDH5,UBA1,RTN3,ATP6V1B2,MMP9	583	
Cell Death and Survival	cell death	cell death of fibroblasts	3.97E-06	 	0.651	 	0.189	BMP4,UNC5B,SPHK2,HRAS,SH3GLB1,CDKN2C,MYC,SGPL1,CTSD,TNIP1,IKBKG,RHOB,RARA,SMARCB1,TSC2,LUM,NUPR1,GSK3B,HIPK2,NSMAF,BIRC3,KLF2,UNG,MCL1,ATG7,ATF3,TNFRSF10B,LMNA,PAWR,RAD51D,GPX7,BCL2L1,DUSP1,PRKCD,PPP1R15A,IGFBP3,MAP2K3,GNL3,SFRP1,PIDD1,PDGFD,NOTCH1,mir-21,MLKL,EPHX1,TNFAIP8,DDIT3,NELFB,FGF2,BMP2,ABL1,TNFSF10,CASP4,IRF3,DIABLO,TGM2,HMOX1,NFKBIA,JUN,STUB1,TIMP1,FLNA,SMO,RPS6KB2,S100A8,RASSF5,SRC,PERP,EMD,IGF2R,CYP1B1,NFE2L1,SLK,CAPNS1,DHCR24,CAT,TPP1	77	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	BCR-ABL T315A-positive Philadelphia-positive acute lymphoblastic leukemia	BCR-ABL T315A-positive Philadelphia-positive acute lymphoblastic leukemia	3.97E-06	 	 	 	 	SRC,CSK,LYN,ABL1,KIT,RET,AXL,CSF1R,TEK	9	
Cellular Movement, Connective Tissue Development and Function	cell movement	cell movement of fibroblasts	4.13E-06	 	0.439	 	-1.130	ITGB1BP1,HRAS,SDC4,MYC,TGFBR2,SGPL1,RHOB,CAV1,ELN,CALCRL,DPT,SPP1,TMEM201,PLEC,HBEGF,PRKCD,CAPN2,RAMP3,CYR61,PDGFD,PTPRA,TNS1,mir-21,COL7A1,APOE,LEP,FGF2,BMP2,ADIPOQ,ABL1,RAMP2,ENAH,JUN,CCL2,EDN1,RHOD,THBS1,SMO,CYGB,PRKCE,ENPP2,ERBB2,MAPKAPK2,LPP,AGT,SRC,ANGPT1,ARHGAP4,PLAUR,IGF2R,COL1A1,FOS,CAPNS1,LPAR1,S1PR1,MAP3K8	56	
Cell Death and Survival	apoptosis	apoptosis of prostate cancer cell lines	4.16E-06	 	0.109	 	0.091	SOCS3,HSPA1A/HSPA1B,SPHK2,KLF6,HRAS,TYMP,IL6,HSPA5,MYC,ETS2,CAV1,SIAH2,BIRC3,MCL1,NOX4,FST,NDRG1,TNFRSF10B,HBEGF,PAWR,BCL2L1,PRKCD,IGFBP3,ALCAM,ACACA,MAP2K3,mir-21,AKAP12,PEBP1,MME,IGFBP4,BMP2,GDF15,ABL1,TNFSF10,HIF1A,NGF,DIABLO,ID1,NFKBIA,JUN,EDN1,GADD45A,DKK3,STUB1,PRKCE,SRC,PAK4,EGR1,SMAD7,PLAUR,DEFB1,FOS,CAT,PTGS2	55	
Molecular Transport	quantity	quantity of metal	4.25E-06	 	-0.135	 	-2.236	NNAT,SGK1,CACNA1H,HRAS,POMC,IL6,ATP2A2,SLC9A1,SLC8B1,GNA15,NMUR2,MCOLN3,MGP,CAV1,CASQ2,MCL1,SELE,PPP1R1B,THY1,GRK5,S1PR3,EPB42,SPINT2,TFRC,ALAS2,FTH1,ADM,FYN,APOE,FGF2,GNA11,ACKR2,HYOU1,FKBP1A,TGM2,TRIB1,LYZ,CCL3L1,CCL2,CCL8,CCL3L3,STIM1,ADORA1,FCGR3A/FCGR3B,CCR1,CYP11A1,S100A1,SIGMAR1,C5AR1,CSK,FOS,HP,SWAP70,S100A9,TF,WAS,LYN,FCER1G,S1PR1,MS4A2,BMPER,PTGS2,NEDD9,ADRA1A,RGS1,ADRBK1,ATP2B1,SPHK2,TRPM8,CXCL12,FCER1A,HSPA5,MYC,CAMK2D,PLCE1,PLA2G5,PRND,C1QBP,CAST,NEDD4L,ADRA1B,EIF2AK1,ELN,CXCL8,SPP1,ADAMTS1,STK39,ITPR2,FIG4,TPSAB1/TPSB2,BCL2L1,NOL3,ORM1,ADRA2A,COMMD1,AKR1B1,ESR1,TMOD1,VHL,PTGFR,SFTPD,LEP,ZP3,BMP2,SLC4A11,SMPD1,NGF,CCL3,HMOX1,SHC1,CCL13,EDN1,MCAM,SAA1,HSD11B2,S100A8,ASIP,AGT,PRNP,SRC,VCAM1,CD59,CXCR4,AP3D1,SLC12A2,AP3B2,MT1A,BTK,PMP22,VAV3,EDNRA,NUCB2,KDR,P2RX7	134	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking	adhesion	adhesion of immune cells	4.35E-06	 	0.788	bias	-1.583	CTSG,ELANE,HRAS,C1QA,SLC35C1,IL6,SPI1,MYADM,TXN,SELE,THY1,THBD,NINJ1,PIP5K1C,ALCAM,PLTP,MAPK7,ITGA7,NRP1,FYN,APOE,ADAM17,GDF15,ADIPOQ,TGM2,CCL2,CCL3L1,RHOD,CCL3L3,ANXA5,LIPG,LBP,RASSF5,ADORA1,FCGR3A/FCGR3B,CCR1,CD209,ANGPT1,CSK,CD69,RGS16,AXL,F11R,SWAP70,S100A9,LSP1,PROCR,LYN,BMPER,PTGS2,NEDD9,RGS1,CD4,CD36,CXCL12,MYC,TGFBR2,TNIP1,RHOB,STAB1,LTBR,FAM65B,MARCO,RASGRP2,FERMT3,CSF3R,CXCL8,MIF,SPP1,ITGAM,ORM1,RAP1GAP,CD14,AOC3,SFTPD,ZP3,ABL1,HIF1A,CCL3,GLRX,NFKBIA,THBS1,MCAM,KIT,S100A8,PTGER4,AGT,SRC,VCAM1,CXCR4,PLAUR,DNAJC1,BTK,VAV3,CXCL2,CERCAM,CLEC10A,P2RX7	98	
Digestive System Development and Function, Hepatic System Development and Function, Organ Morphology, Organismal Development	morphology	morphology of liver	4.40E-06	 	 	 	 	LIG1,SOCS3,PLIN1,RRM2B,ZFPM1,MST1,IL6,SPI1,MYC,TYSND1,IKBKG,MTHFD2,GSK3B,HADHA,MIF,SPP1,LMNA,JUNB,CTSA,ERCC1,BSG,PKD1,DUSP1,NAGLU,RGN,ESR1,TXNRD2,VHL,COL3A1,SPTBN1,APOE,CFC1/CFC1B,ABL1,CDK4,ADIPOQ,CTHRC1,HEXA,SMPD1,ABCA5,VTI1B,RAMP2,CIAPIN1,SLC19A3,AEBP1,MAN2C1,JUN,GBA,THBS1,HMGCL,CCR1,SLC20A1,MYCN,SRC,NQO1,HYAL1,SNX27,BSCL2,TK2,AGL,IGF2R,NFE2L1,GRN,COL1A1,KRT8,ZFPM2,LDLR,CBS/CBSL,MAN2B1,PTGS2,ZFP36L2,ARID4A	71	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	size	size of tumor	4.41E-06	Decreased	-2.157	 	-2.303	LEP,FGF2,ANTXR1,KLF6,CA12,ADIPOQ,HRAS,IL6,MYC,TGFBR2,DIABLO,HINT1,JUN,TIMP1,ETS2,SMO,CAV1,VEGFD,CD24,STAB1,ERBB2,LTBR,RET,COL18A1,SRC,MIF,JUNB,ERCC2,CBR3,PLA2G4A,KRT8,CCND2,PRKCD,WBP2,ITGA1,MAPK7,PTGS2,KDR,MMP9,NRP1	40	
Cardiovascular System Development and Function, Tissue Development	morphogenesis	morphogenesis of cardiovascular tissue	4.42E-06	 	-0.374	bias	-1.478	PIK3C2B,CXCL8,VCAM1,FGF2,MMP2,NGF,ODC1,STC1,EFNB2,COL1A1,ID1,JUN,RHOB,TNMD,MAP2K3,CSNK2B,CXCL2,COL18A1,NOTCH1,TMOD1,PLOD3	21	
Cell Morphology, Cellular Function and Maintenance	autophagy	autophagy	4.48E-06	 	1.840	 	0.820	CAMK1,WDR45,HRAS,SH3GLB1,IL6,ATG9A,GAA,SPTLC2,MCOLN3,TSC2,DNAJA3,ATF4,MYL3,MCL1,ATG7,DDIT4,NDRG1,SOGA1,TNFRSF10B,NLRX1,S1PR3,HSPA8,DVL2,CTSA,NR1D1,SQSTM1,TUFM,DDIT3,DAPK2,LEPR,ADIPOQ,TNFSF10,FKBP1A,VTI1B,EIF4EBP1,MCOLN1,MTOR,GBA,CCL2,STIM1,PIK3R2,HGS,TBC1D10B,AMFR,ABHD5,VPS18,UCP2,MVB12A,TRIB3,ACLY,PLA2G4A,LAMP2,S100A9,SERPINH1,BMF,BNIP3L,VPS28,SESN2,CD4,CXCL12,HSPA5,MYC,CTSD,IKBKG,PLCE1,MAP2K2,GABARAPL1,NUPR1,GSK3B,CAST,KIF25,TRIM5,PDK4,SPP1,ACP2,ARSA,FLCN,BCL2L1,PCGF1,PLEKHF1,PRKCD,SORCS2,IDO1,TBC1D16,VPS37A,UVRAG,SH3BP4,LEP,VPS37D,SRPX,ERN1,PKM,ABL1,UBASH3B,SMPD1,HIF1A,NGF,HMOX1,SHC1,VPS25,STUB1,S100A8,ATP13A2,AGT,GJA4,PRNP,CXCR4,NQO1,LRRK2,QSOX1,CAPNS1,CAT,TBC1D7,CYB5A,DNM1L,KDR	116	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	neoplasia	Renal Cancer and Tumors	4.49E-06	 	-0.638	 	-0.484	CBX7,PCLO,VAC14,TPRG1,IL6,NPL,SLC39A8,POR,UPK3BL,GLB1,AJUBA,KEAP1,SMARCB1,ARHGAP39,TSC2,CAV1,DEFB132,PIGT,WASH3P,TSHZ2,PTGIS,SLC2A5,STK36,PPP1R1B,RANBP3,LARP4,PTPN3,IFNAR2,SHROOM4,NRDE2,PDLIM7,CDH5,BTG2,GCC1,ZDHHC1,KIAA1217,EPHX1,CD163L1,NME1,PSMD7,FGF2,OSGIN1,IGSF1,CUBN,GNA11,CTDSPL,POFUT2,CCL2,ARFGAP1,PLIN2,IL34,ADORA1,CYP51A1,ALDH5A1,CCR1,S100A1,MECOM,TJP1,DGAT2,FOS,ARHGEF5,HNRNPH1,FLNC,ATP1A2,TAF1C,SOX9,MAP3K8,BMP6,RBP5,C11orf68,HAGH,ARSD,SESN2,ATP2B1,ABCA3,KLF6,DIRAS1,INTS1,GPC3,MYC,TGFBR2,LHFPL2,RHOB,GPR4,MOCOS,TUBA1C,TEK,MARCO,CXCL8,LRBA,H19,MAST4,RILPL1,LAMA2,VEGFC,ERCC2,DCHS1,GUF1,FAAP20,BCL2L1,RPL8,AEBP2,BAP1,C17orf97,ESR1,VHL,S100P,SUN1,PTGFR,SLC1A4,RPH3AL,GSTT1,HNRNPK,IRAK1,RPL14,POLR1C,HLA-DRB1,AHNAK,TIMP1,SAA1,ERBB2,MCRS1,NUSAP1,TUBG1,G6PD,GNAI1,PLAUR,PYGB,CXCL16,RRAS2,POLR3B,SMG7,CDC34,CXCL2,NNAT,PRUNE2,DDX11,SLC29A4,MSRB2,PCDH17,CDKN2C,ZNF605,KIF21A,ANK2,PIK3C2B,CALCRL,NANOS1,ZC3HC1,CENPB,TUBB2A,MMP2,THBD,FAHD2B,RAE1,SH3GL1,CCDC136,AQP9,SRGAP3,CCZ1/CCZ1B,TIMP4,CCND2,BSG,EPB42,NPRL3,IL10RA,TRO,CCT3,RPL6,RSU1,MAP2K3,ALAS2,MAPK7,SFRP1,AIDA,CYR61,TMEM158,NOTCH1,PHLPP1,ADM,MME,SPTBN1,HIST1H1C,ADAM17,RALA,SERAC1,BTG3,TNFSF10,XPOT,FKBP1A,TBL3,ATP6AP1,IDH1,TRIB1,CADM2,MTOR,ANXA5,COL22A1,PRKCE,PTPRT,AHNAK2,NPRL2,MYCN,PLXNA1,GSTM1,CD276,MGMT,DEFB1,SLIT2,AXL,GABRE,TRMT12,MRPL51,COL5A3,KRT8,LMO3,MCM2,PPP1R16B,SBF1,NOP2,BNIP3L,GABARAP,ATAD3A,ZFP36L2,FBN2,RGS1,SPNS1,CLEC3B,XPO5,SLC35F1,TPM1,TUBB,GUSB,METAP2,GSPT1,ETS2,ASXL2,ACP6,MCTP1,SIAH2,RET,FAM65B,PDK4,MFSD3,AXIN2,ACSL3,TRIOBP,NUP155,EGR3,NDUFAF2,INHBB,FLCN,PANK1,PPP2R1A,SMOX,RAP1GAP,PRKCD,RGN,LMAN2L,XPNPEP1,TMOD1,CDK5RAP2,MAP2K5,RNPEP,ADAMTS7,PKM,ABL1,CDH23,HIF1A,ACOT7,FAM110B,EPHB6,HMOX1,NFKBIA,PCK2,CSPG4,THBS1,FLNA,KCNMA1,FUBP3,KIT,ASAP3,CUL9,ZNF493,CHEK2,ASIP,TMEM132B,FAAH,LXN,SNAPC4,FRMD1,EPAS1,TPST2,SMAD7,LRRK2,ZBTB7C,NFKBIZ,CSF1R,TSPAN1,ACAT1,GLMP,KDR,XK,SLC47A1,MMP9,DHRS7B	305	
Tissue Development	development	development of connective tissue	4.61E-06	 	-0.198	 	-1.488	BMP4,CTGF,CACNA1H,MST1,HRAS,IL6,SPI1,SATB2,MFAP2,LGMN,LPIN1,RARA,CAV1,TXN,HIPK2,SFRP4,HBEGF,MMP2,SFRP1,SQSTM1,MAPK7,CYR61,NOTCH1,mir-21,ADM,MAP7,NOL7,SLC4A2,FGF2,ADIPOQ,CDK4,TNFSF10,VCAN,MAFG,JUN,CCL2,CCL3L3,CST3,SOS1,SNX10,SLC19A1,STIM1,CYP51A1,HEY1,ADRM1,MECOM,ZNF521,COL12A1,EGR1,THNSL2,CYP1B1,GRN,PLA2G4A,FOS,LDLR,DHCR24,WAS,BMPER,SOX9,PTGS2,ARID4A,SOCS3,GNPDA1,CLEC3B,ZFPM1,MYC,TGFBR2,GSK3B,CSF3R,CXCL8,AXIN2,MIF,FST,ADAMTS1,KLF4,RUNX1,SULF1,LOX,ADAMTS7,SFRP2,LEP,FRZB,BMP2,CHPF,ABL1,HIF1A,ITGA10,CCL3,PDCD4,NFKBIA,EDN1,FLNA,CSPG4,FNDC5,KIT,S100A8,SULF2,ACTN1,SRC,VCAM1,SMAD7,G6PD,F13A1,SCIN,BSCL2,NUP210L,CSF1R,SH3PXD2A,XYLT2,EBF1,SPARC,COL11A1,EFEMP2,CARM1	114	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	invasion	invasion of malignant tumor	4.70E-06	 	1.296	bias	-0.230	NME1,LEP,FGF2,BMP2,PTTG1,GDF15,LHCGR,CXCL12,HRAS,TYMP,IL6,HSPA5,VCAN,TGFBR2,ID1,HMOX1,RHOB,EDN1,CCL2,MCAM,ERBB2,AHCY,ETS1,SRC,CDKN1C,SPP1,CXCR4,PLAUR,MMP2,KLF4,S100A9,BSG,VAV3,CTSB,ALCAM,RGN,CAPN2,ITGA1,PTGS2,SFRP1,NEDD9,NOTCH1,MMP9,mir-21,MAP2K5,S100P,NRP1	47	
Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of lamellipodia	4.84E-06	 	1.294	bias	-0.541	FYN,CTGF,FGF2,WASF3,ADIPOQ,CXCL12,HRAS,SDC4,NGF,PHLDB2,TNFRSF12A,PLEKHG4,MYC,PARVB,RAB5A,MTOR,ADGRF5,RHOB,CCL2,AJUBA,RHOD,DKK3,KIT,ERBB2,C1QBP,RET,MARCO,FERMT3,SRC,ARHGEF4,PARVA,CHN1,CARMIL1,PVR,SLIT2,BTK,SWAP70,BSG,LPAR1,FSCN1,VAV3,NCF2,ARHGEF6,S1PR1,SNX1,SPARC,CYR61,DNM1L,NRP1	49	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of colorectal cancer cell lines	4.85E-06	 	1.146	 	0.282	PHLDA1,EIF3C,BMP4,VPS28,AXIN1,HRAS,CES2,SDC4,MYC,TGFBR2,PADI4,POR,CTSD,AHSA1,PLCE1,EGR2,CSE1L,HIPK2,CDC16,RBM38,MIF,SELE,FST,GRK5,SNRK,KLF4,BCL2L1,PRKCD,MAPK7,NOTCH1,UVRAG,UBE2I,PHLPP1,IGFBP4,LEP,DAPK2,BMP2,CHCHD6,PKM,TNFSF10,RARRES1,HIF1A,SOX17,ID1,DUSP5,RABL6,ANGPTL4,EDN1,GADD45A,THBS1,MEG3,PRKCE,CD24,ERBB2,RASSF5,COL18A1,PRPF31,NCL,CHEK2,AGT,EMILIN1,SRC,PAK4,SMAD7,COPS3,IGF2R,MT1A,GRN,NTRK3,SPRY2,NR5A2,SPARC,SOX9,PTGS2,UBA1,NEDD9,DSG2,PPIL1	78	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	transmigration	transmigration of leukocytes	4.87E-06	 	0.190	bias	-1.401	CNN2,AOC3,ADAM17,RARRES2,GDF15,ABL1,ELANE,CXCL12,MYLK,CCL3,TGM2,EFNB2,SHC1,MTOR,CCL2,CCL3L3,MCAM,STAB1,ENPP2,ADORA1,CCR1,FERMT3,CXCL8,CD209,SRC,VCAM1,SELE,CXCR4,THY1,PVR,NINJ1,STC1,F11R,COL1A1,ITGAM,LDLR,VAV3,RTN4,CD86,CXCL2,NOTCH1,MMP9	42	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	estrogen receptor-negative breast cancer	estrogen receptor-negative breast cancer	4.91E-06	 	 	 	 	CTGF,TGFBR3,PARP2,LHCGR,CDKN2C,IL6,SPI1,MYC,POR,TGFBR2,ETS2,CAV1,TUBA1C,RET,TEK,CSF3R,ETS1,CXCL8,IGFBP6,SPP1,TUBB2A,MMP2,PARP3,JUNB,CCND2,IGFBP3,ESR1,mir-21,FYN,FRZB,FGF2,TNFSF10,HIF1A,JUN,TIMP1,KIT,ERBB2,NCL,PLAT,MYCN,CD276,EGR1,NQO1,TUBG1,CSF1R,PLA2G2A,FOS,NTRK3,MAP3K8,KDR,MMP9	51	
Cell Death and Survival	apoptosis	apoptosis of blood cells	5.02E-06	 	0.740	 	1.568	BMP4,SERPINA3,C1QA,IL6,SPI1,HOXA9,NR4A3,RARA,CAV1,DNAJA3,IRS2,HIPK2,MCL1,ETS1,TNFRSF21,STOML2,IER3,HAX1,MAP2K3,NOTCH1,APOE,HIST1H1C,FYN,ADAM17,GADD45B,DDIT3,LEPR,NQO2,TNFSF10,CASP4,MTOR,JUN,CCL2,CCL3L3,CSF2RA,PRKCE,HCAR2,FCGR3A/FCGR3B,PLAT,MECOM,EGR1,TRIM28,CD69,ST3GAL3,ID3,FOS,GPAM,PLA2G4A,SWAP70,LDLR,WAS,BMF,LYN,FCER1G,MS4A2,BNIP3L,PIN1,TNFRSF4,PFN1,LAMTOR2,CD4,HAVCR2,POLR3E,CXCL12,FCER1A,ABCG1,MYC,CTSD,ETS2,GIMAP5,GSK3B,LTBR,CCDC86,CAST,BIRC3,KLF2,CXCL8,MIF,SPP1,DNASE2,ATF3,EGR3,ITPR2,BTG1,PAWR,THRA,KLF4,PKN1,TPSAB1/TPSB2,BCL2L1,ITGAM,PRKCD,CD14,IDO1,VHL,MAP2K5,RUNX1,SFTPD,LEP,TPR,ABL1,TNFAIP3,SMPD1,IRF3,HIF1A,NGF,CCL3,SOX17,HLA-G,SHC1,NFKBIA,STUB1,TIMP1,THBS1,DKK3,S100A8,CUL9,CHEK2,PTGER4,CD59,EPAS1,CXCR4,NQO1,SMAD7,PERP,FAIM,BTK,RCAN1,COL1A1,VAV3,CAT,CXCL2,RCAN2,P2RX7	134	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	inborn error of carbohydrate metabolism	inborn error of carbohydrate metabolism	5.08E-06	 	 	 	 	GMPPB,SGSH,DPM2,SLC35C1,GUSB,G6PC3,SLC39A8,NEU1,IDUA,MCOLN1,GYS1,GLB1,GAA,HLCS,ALG8,POMGNT2,FCGR3A/FCGR3B,ADRB2,FUCA1,PSMB5,DDOST,DPAGT1,HYAL1,G6PD,AGL,POMGNT1,RBCK1,LARGE1,COG5,CTSA,ALG3,PSMB2,GALE,ATP6V0A2,NAGLU,GBE1,FBP1,HOGA1,TMEM165	39	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of acylglycerol	5.11E-06	 	1.182	 	1.011	APOB,PFKFB1,CD36,RGCC,HRAS,LIPE,C1QA,POMC,IL6,ATP2A2,NEU1,POR,MYC,LPIN1,PLA2G5,PCYT2,CXCL14,CAV1,IRS2,ADRA1B,PDK4,MIF,SPP1,CIDEC,LMNA,THRA,ECI1,PANK1,AQP9,ERCC1,DUSP1,HIF1AN,RGN,SLC27A1,ITGA1,ACACA,PLTP,ADIPOR2,AKR1B1,APOE,ANGPTL8,LEP,LEPR,PPP1R3C,GNA11,ADIPOQ,SMPD1,IDH1,TRIB1,AADAC,AEBP1,HINT1,CES1,ANGPTL4,JUN,EDN1,PCK2,SORBS1,PDE3B,PLIN2,LOC102724428/SIK1,PRKCE,LIPG,LDLRAP1,IFRD1,ADORA1,COL18A1,HCAR2,CTDNEP1,AGT,FAAH,SRC,SLC25A13,ABHD5,FMO3,UCP2,CYP27A1,EGR1,NQO1,DGAT2,LPGAT1,BSCL2,ACLY,ZPR1,THRSP,GPAM,CIDEA,PMP22,LDLR,DGKQ,CBS/CBSL,APOC1,FKBP4,PTGS2,P2RX7	95	
Connective Tissue Development and Function, Tissue Morphology	mass	mass of connective tissue	5.14E-06	 	1.582	 	1.073	PLIN1,PTTG1,LIPE,POMC,IL6,PNRC2,G0S2,LPIN1,BCAT2,CAV1,ATF4,IRS2,GSK3B,SLC2A5,RBM38,SPP1,ATF3,ATG7,SURF1,CIDEC,LMNA,JUNB,NPY5R,FOSB,DUSP1,HIF1AN,IGFBP3,ADIPOR2,ESR1,IGFBP4,APOE,LEP,LEPR,GDF15,ADIPOQ,CEBPD,WDR13,EIF4EBP1,TRIB1,PCK2,CSPG4,PDE3B,DUSP10,PLIN2,FNDC5,ENPP2,ADRB2,AGT,UCP2,C5AR1,ZNF521,HDC,GFRA2,BSCL2,CCDC3,GPAM,LDLR,DHCR24,ATP1A2,APOC1,PTGS2	61	
Cancer, Organismal Injury and Abnormalities	metastatic solid tumor	metastatic solid tumor	5.22E-06	 	-0.081	 	-0.533	DPYD,CTGF,KCNJ2,TGFBR3,HRAS,CDKN2C,GYG2,ACP5,IL6,HOXA9,PCOLCE,POR,PLS3,CSE1L,CAV1,NDRG1,GSTM3,TNFRSF10B,TUBB2A,MMP2,PARP3,TNK2,IFNAR2,HAX1,CDH2,ISLR,COLEC12,CCND2,GLUL,SFRP1,mir-21,MME,MSC,ZFP36,TCEA1,NID2,SRD5A1,GDF15,CDK4,CEBPD,FKBP1A,C1R,MTOR,CCL2,CD24,PRKCE,COL18A1,TRIM29,CYP51A1,FCGR3A/FCGR3B,PLAT,SLC12A8,EPB41L4B,OLFML3,AXL,POLD1,PTGS2,ABCC3,ZFP36L2,TM4SF1,FZD7,FBN2,QPCT,AKR1C3,CD36,PTTG1,RTN1,PARP2,KLF6,LHCGR,CXCL12,RNASE1,DNAJB2,TUBB,MAP2K2,TUBA1C,RET,CLCN3,PDZRN3,TEK,PTX3,CXCL8,SPP1,FST,ADAMTS1,VEGFC,CAPG,ERCC2,GSR,BCL2L1,EFS,PPP2R1A,ERCC1,COL6A3,SCRIB,LSM7,DNAJB6,CRABP2,ESR1,ERAP2,SRPX,EPB41L3,FLRT2,ABL1,EMX2,HIF1A,GLRX,GSTT1,HMOX1,EDN1,THBS1,FLNA,SMO,LOC102724428/SIK1,KIT,RNH1,ENPP2,ERBB2,RNF144B,ALPL,PRNP,VCAM1,CXCR4,TUBG1,PLAUR,PLSCR4,CPA4,CSF1R,ATIC,EMP1,NEK11,CLGN,CAT,KDR,DSG2,MMP9	136	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of leukocytes	5.30E-06	 	0.197	 	-1.879	C1QA,IL6,SLC35C1,SPI1,EGR2,CCND3,LUM,ST6GALNAC2,TNFRSF21,ETS1,CLEC4G,SELE,MFAP5,IFNAR2,HAX1,ARHGEF6,CD86,APOE,GADD45B,DDIT3,GDF15,ACKR2,ADIPOQ,G6PC3,DIABLO,TGM2,CCL2,GADD45A,SORBS1,IL34,CCR1,TSTA3,CD69,TOB1,ID3,CBR3,IGF2R,GPR183,FOS,ARHGEF5,SWAP70,LDLR,CBS/CBSL,LYN,ARHGDIA,TP53BP1,MAP3K8,NDST2,ST3GAL4,LIG1,SOCS3,HAVCR2,MBP,PTTG1,POLR3E,FCER1A,ABCG1,STARD7,MYC,TGFBR2,CTSD,ADGRF5,CXCL14,STAB1,NEDD4L,BIRC3,TEK,CXCL8,ATF3,DOK2,LAMA2,THRA,KLF4,FOSB,BCL2L1,DUSP1,FAM26F,IGFBP3,MDK,ESR1,RUNX1,LITAF,SFTPD,MPZL2,CCL3,ETV6,IRAK1,HLA-G,ALDH2,SHC1,HLA-DRB1,TIMP1,SAA1,ERBB2,AGT,SLC20A1,SRC,VCAM1,NQO1,ST3GAL6,PSME3,BTK,CXCL16,VAV3,CXCL2,APOB,TYRO3,MAF,HRAS,CDKN2C,HOXA9,SGPL1,MFAP2,ITGA3,LGMN,RARA,MGAT4B,DNAJA3,APEX2,MCL1,CALCRL,CMKLR1,ATG7,DKC1,HBEGF,THBD,S1PR3,IL10RA,MAPK7,NOTCH1,CNN2,FYN,ADAM17,ZFP36,PSMB10,LEPR,NQO2,SIN3B,TNFSF10,MYH11,EFNB2,ID1,TRIB1,CES1,GBA,CCL3L3,SLC19A1,PRKCE,LIPG,RASSF5,PLAT,C5AR1,TYROBP,IMPDH2,EGR1,HDC,AXL,S100A9,TF,WAS,BMF,LSP1,FCER1G,PTGS2,ZFP36L2,NEDD9,ARID4A,RGS1,TNFRSF4,CD36,CD4,SPHK2,PLA2G15,LHCGR,CXCL12,IKBKG,TNIP1,PLCE1,ETS2,COMT,LTBR,STX11,FERMT3,CSF3R,MIF,SPP1,DNASE2,EGR3,FZD9,PAWR,PKN1,ITGAM,ERCC1,PRKCD,IDO1,UVRAG,LEP,ABL1,TNFAIP3,TET1,SMPD1,HIF1A,NGF,CDKN2B,HMOX1,HINT1,NFKBIA,DKK3,FLNA,THBS1,DUSP10,SMO,KIT,S100A8,HCST,MAPKAPK2,ALPL,RHBDD3,PRNP,FAAH,CYP27A1,CXCR4,VSIG4,F13A1,CCDC3,IL20RB,CSF1R,EBF1,CYTIP,PAG1,FASTK,JCHAIN,ACAT1,C6,P2RX7,MMP9,CLEC10A,CARM1	238	
Dermatological Diseases and Conditions, Inflammatory Disease, Inflammatory Response	dermatitis	Dermatitis	5.37E-06	 	1.148	 	1.894	PLIN1,NCSTN,POMC,IL6,SPI1,ODC1,POR,LGMN,ZNF395,RARA,VEGFD,AHCY,MCL1,SELE,TUBB2A,MAD2L2,FLOT1,JUNB,BRF2,THBD,IFNAR2,PSMB2,MAP2K3,NOTCH1,MME,FYN,APOE,ADAM17,ZFP36,LEPR,ACKR2,ADIPOQ,TNFSF10,FKBP1A,RUVBL1,IFI27,MTOR,JUN,GADD45A,CSF2RA,CST3,ANXA5,SOCS2,STIM1,CYP51A1,P4HA2,FCER2,BLMH,C5AR1,CSK,DEFB1,NR4A2,LDLR,S100A9,LYN,FCER1G,FKBP4,MS4A2,ARHGDIA,PTGS2,SOCS3,NAGK,ADRBK1,CD4,HAVCR2,FCER1A,TPM1,STARD7,IKBKG,HDAC11,TUBA1C,DDX41,CPNE1,PDK4,CXCL8,PSMB5,HNMT,TRIOBP,SHARPIN,VEGFC,CAPG,RAB34,GSR,BCL2L1,H3F3A/H3F3B,DUSP1,CCL18,UBE2I,SFTPD,SCARA5,ABL1,TNFAIP3,ELOVL3,SMPD1,CD55,HLA-DRB1,NFKBIA,CCL13,AHNAK,TIMP1,FLNA,THBS1,MCAM,DUSP10,KIT,S100A8,SRC,NLRP3,CXCR4,TUBG1,SMAD7,NFKBIZ,ENO1,ACADVL,CYTIP,CAT,RPS6KA4,KDR,FCGBP	119	
Protein Trafficking	targeting	targeting of protein	5.65E-06	 	 	 	 	SORL1,TOMM40,RAB3IP,LTBP2,TIMM10,AHCYL1,NLGN1,PPP1R3C,TPR,RAN,XPO5,LHCGR,FOLR2,HOMER3,IFI27,SNX16,EGR2,PEX16,SEC61A1,RHOD,CSE1L,MICALL1,GSK3B,CHCHD4,ADORA1,HGS,WASH3P,PEX6,PACS1,PEX7,AP1S2,HSPA9,NBEA,LONP2,HSPA8,EXOC4,PKD1,GIPC1,TOMM34,GABARAP,XPO6	41	
Cardiovascular System Development and Function, Tissue Morphology	permeability	permeability of vascular system	5.73E-06	 	-0.193	 	-0.895	APOE,FGF2,CTSG,CXCL12,TNFSF10,MYLK,RNASE1,NGF,CCL3,RAMP2,TNFRSF12A,DTNA,ESAM,ID1,GADD45A,TIMP1,THBS1,ABR,MYADM,CAV1,COL18A1,ADORA1,MAPKAPK2,TEK,PLAT,PTX3,CXCL8,SRC,MIF,ANGPT1,LAMA2,VEGFC,MMP2,MYOF,AXL,F11R,LDLR,CDH5,CBS/CBSL,RAP1GAP,LSP1,S1PR1,PROCR,ARHGDIA,MAPK7,PTGS2,KDR,CXCL2,MMP9	49	
Cardiovascular System Development and Function, Organ Development	function	function of heart	5.74E-06	 	-1.025	 	-2.674	APOB,PFKFB1,ADRBK1,CXCL12,IL6,ATP2A2,IDUA,CAMK2D,PLCE1,PLA2G5,NUPR1,CAV1,GSK3B,HEY2,NEDD4L,BIRC3,CASQ2,ADRA1B,ELN,KCNJ8,SPP1,APLNR,HBEGF,LMNA,THRA,MMP2,IER3,THBD,TIMP4,NOL3,NOTCH1,MAP2K5,ADM,APOE,LEP,FGF2,PPP1R1A,GDF15,ADIPOQ,FKBP1A,TNFAIP3,NGF,HMOX1,SHC1,EDN1,KIT,ASPH,ADORA1,ABCC9,LIG3,ADRB2,PLAT,AGT,S100A1,SIGMAR1,MTMR14,SMAD7,ENO1,LAMP2,ZFPM2,LDLR,LIMS1,VAV3,ATP1A2,DNM1L,MMP9,MAOA	67	
Endocrine System Disorders, Gastrointestinal Disease, Metabolic Disease, Organismal Injury and Abnormalities	diabetic foot ulcer disorder	diabetic foot ulcer disorder	5.76E-06	 	 	 	 	COL5A2,COL4A5,COL6A2,COL12A1,COL8A1,GSS,COL15A1,COL1A2,COL16A1,COL5A1,COL1A1,COL5A3,COL6A1,COL6A3,COL22A1,COL11A1,COL18A1,COL3A1,COL7A1	19	
Energy Production, Lipid Metabolism, Small Molecule Biochemistry	oxidation	oxidation of fatty acid	5.78E-06	 	-1.154	 	-2.238	PLIN1,SESN2,CD36,LIPE,POMC,IL6,MYC,TYSND1,POR,NR4A3,G0S2,LPIN1,IRS2,HADHA,PDK4,ACSL3,ATG7,PEX7,LONP2,ECI1,SLC22A5,ACACA,SLC27A1,ADIPOR2,APOE,LEP,C1QTNF1,ADH1C,ADIPOQ,HIF1A,GCDH,AADAC,MTOR,CYGB,ACSL4,LRPPRC,GOT2,ABCC9,ACADM,ABHD5,EPAS1,UCP2,DGAT2,RGS16,SLCO2A1,TK2,GPAM,NR4A2,IMMT,ACADVL,NUCB2,PTGS2	52	
Dermatological Diseases and Conditions, Developmental Disorder, Organismal Injury and Abnormalities	congenital anomaly of skin	congenital anomaly of skin	5.78E-06	 	 	 	 	ABCB6,CSTA,HRAS,IKBKG,ITGA3,TSC2,PTGIS,ELN,PARN,DKC1,PLEC,LMNA,ERCC2,PLOD1,IFT122,RTN4,NOTCH1,DOCK6,VHL,EOGT,COL3A1,PYCR1,COL7A1,ADM,B3GALT6,DDIT3,ANTXR1,NHP2,FKBP1A,EIF4EBP1,COL5A1,COL1A2,EVC,HMOX1,B4GALT7,MTOR,NFKBIA,FLNA,KIT,KCTD1,GJB2,BEX2,ABHD5,PKP1,COL5A2,SERPINE2,COL1A1,CYP4F22,ATP6V0A2,COL11A1,EFEMP2	51	
Cell Death and Survival	cell death	cell death of phagocytes	5.79E-06	 	0.418	 	0.191	LAMTOR2,HAVCR2,RAN,CXCL12,FCER1A,SERPINA3,C1QA,ABCG1,IL6,NR4A3,LTBR,CAST,GSK3B,BIRC3,MCL1,CXCL8,MIF,ATF3,BTG1,TPSAB1/TPSB2,BCL2L1,PRKCD,CTSB,CD14,MAP2K3,NOTCH1,APOE,ADAM17,SFTPD,LEP,DDIT3,LEPR,TNFSF10,TNFAIP3,CASP4,SMPD1,IRF3,HIF1A,NGF,IRAK1,HMOX1,LYZ,MTOR,NFKBIA,CCL2,PRKCE,S100A8,HCAR2,PTGER4,PLAT,NLRP3,CXCR4,BTK,FOS,PLA2G4A,LDLR,CAT,FCER1G,MS4A2,ACAT1,CXCL2,P2RX7	62	
Organismal Injury and Abnormalities	nodule	nodule	5.80E-06	 	-1.446	 	-1.950	CCR1,SPP1,BMP4,LEP,CTGF,DDIT3,CXCR4,PRDX5,BMP2,SMAD7,SMAD6,ABL1,TNFSF10,TOB1,TGM2,CBS/CBSL,ANXA5,CTSB,IGFBP3,VEGFD,SPARC,TPO,PTGS2,BMP6,RBP4	25	
Cardiovascular System Development and Function, Lymphoid Tissue Structure and Development	abnormal morphology	abnormal morphology of tunica media	5.89E-06	 	 	 	 	PTGIS,APOE,CST3,VAV3,MGP,MKL2,TMBIM1,EFEMP2,KLF2,FBN2	10	
Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development	formation	formation of cardiac muscle	5.90E-06	 	 	 	 	BMP2,TGFBR3,SIN3B,ZFPM1,FKBP1A,TPM1,MYH11,MTOR,JUN,MKL2,LY6E,MYL3,PKP2,ANGPT1,DAAM1,SMAD7,PLEC,MESP1,FOXC1,ZFPM2,PIP5K1C,STIP1,ALDH1A2,NPRL3,COL11A1,TAZ,MAPK7,TMOD1,NOTCH1,MAP2K5,RBP4	31	
Cell Death and Survival	cell death	cell death of breast cancer cell lines	6.65E-06	 	0.368	 	0.195	CTGF,SGK1,PTTG1,TGFBR3,HSPA1A/HSPA1B,SPHK2,ELANE,DNAJC15,HSPA5,SLC9A1,ODC1,SLC25A6,ETS2,CSE1L,CAV1,KPNA2,GSK3B,BIRC3,MCL1,MIF,ATG7,DDIT4,LMO4,TNFRSF10B,RPAP3,IER3,GPX7,DPH2,BCL2L1,TIMP4,CCND2,TRIM39,DUSP1,IGFBP3,TFRC,MAP2K3,SFRP1,CRABP2,CYR61,ESR1,CCDC80,NOTCH1,DPH5,FTH1,NRP1,ADM,PEBP1,SULF1,NME1,NACC2,SFRP2,FGF2,OSGIN1,BCL2L12,PKM,ABL1,ADIPOQ,TNFSF10,SMPD1,HIF1A,NGF,PDCD4,DIABLO,HMOX1,HINT1,RABL6,NFKBIA,JUN,GADD45A,PCK2,THBS1,MARCH8,PRKCE,DAB2,ERBB2,HCST,HCAR2,PRNP,BEX2,SRC,RTKN,NQO1,RGS16,NDUFA13,PRMT1,BTK,IRF2BP2,PEA15,BNIP3L,ARHGDIA,PTGS2,CYB5A,ELK1,NEDD9	94	
Cancer, Cellular Movement, Organismal Injury and Abnormalities, Tumor Morphology	invasion	invasion of tumor cells	6.68E-06	 	0.780	 	-0.847	PTTG1,CXCL12,IL6,TGFBR2,MIA,SATB2,RHOB,AHCY,BIRC7,VEGFC,HBEGF,MMP2,KLF4,SCRIB,CTSB,CD14,RGN,ALCAM,CAPN2,ITGA1,SFRP1,NOTCH1,mir-21,MAP2K5,S100P,COL7A1,NRP1,BMP2,GDF15,WASF3,ADIPOQ,FKBP1A,HIF1A,VCAN,PDCD4,HMOX1,ID1,EDN1,FLNA,THBS1,MCAM,CD24,ENPP2,S100A8,ERBB2,SOX7,SRC,CXCR4,PLAUR,SLIT2,S100A9,PTGS2,NEDD9,MMP9	54	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of phospholipid	6.73E-06	 	1.112	bias	-0.937	SOCS3,PIGU,VAC14,SH3GLB1,POMC,PIGQ,SGPL1,SPTLC2,PCYT2,PLA2G5,MTMR2,PTX3,CXCL8,PIK3C2B,PEX7,SERINC1,GPAA1,SERINC2,ABCA8,ACBD6,PIP5K1C,SLC27A1,SCAP,PIGO,RALA,FGF2,PTPMT1,DPM2,ATF6,INPPL1,NGF,MTOR,CES1,CCL2,EDN1,KIT,ENPP2,PI4KB,PI4KA,ADRB2,AGT,ABHD5,PTDSS2,PLA2G4A,GPAM,FOS,PIGB,LYN,PTGS2,TAZ,GAPVD1,KDR,PNPLA6	53	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	progesterone receptor-negative breast cancer	progesterone receptor-negative breast cancer	6.79E-06	 	 	 	 	CTGF,TGFBR3,PARP2,CDKN2C,IL6,SPI1,MYC,POR,TGFBR2,ETS2,CAV1,TUBA1C,RET,TEK,CSF3R,ETS1,CXCL8,IGFBP6,SPP1,TUBB2A,MMP2,PARP3,JUNB,CCND2,FSCN1,IGFBP3,ESR1,mir-21,FYN,FRZB,FGF2,TNFSF10,JUN,TIMP1,KIT,ERBB2,NCL,PLAT,MYCN,CD276,EGR1,NQO1,TUBG1,CSF1R,PLA2G2A,FOS,NTRK3,MAP3K8,KDR,MMP9	50	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	neuroendocrine tumor	neuroendocrine tumor	6.87E-06	 	1.330	 	1.857	AXIN1,PTTG1,WBSCR22,ASS1,DPYSL4,HRAS,CDKN2C,POMC,RNASE1,IL6,ODC1,MIA,POR,CCND3,PDCD6,TUBA1C,GSK3B,RET,ADRA1B,PDK4,ALDOC,SFRP4,SELE,CYYR1,TUBB2A,DKC1,THY1,GALNT13,HMGA1,STX1A,IFNAR2,TMEM127,ADRA2A,ALDH1A2,CTSB,ESR1,mir-21,VHL,MME,LEP,SFRP2,FRZB,ZFP36,PAM16,ABL1,CEBPD,CDK4,FKBP1A,HIF1A,CDKN2B,TGM2,ID1,HMOX1,ALDH2,AEBP1,MTOR,GADD45A,THBS1,KCNMA1,KIT,HSD11B2,ARHGEF2,CDCA5,S100A8,ERBB2,COL18A1,CUL9,MYCN,GSTM1,VCAM1,NUSAP1,EPAS1,EGR1,TUBG1,SLIT2,RELN,CSF1R,HP,COL11A1,KDR,ID4,MMP9,ADRA1A	83	
Cell Death and Survival, Skeletal and Muscular Disorders	necrosis	necrosis of muscle	6.97E-06	 	-0.040	 	1.041	SOCS3,BMP4,CTSG,CXCL12,HRAS,IL6,MYC,NR4A3,IKBKG,CAMK2D,SPTLC2,PLA2G5,CAV1,GSK3B,BIRC3,HADHA,MCL1,HK1,ETS1,CXCL8,NOX4,CALCRL,SPP1,SGCG,TNFRSF10B,LAMA2,PLEC,HBEGF,LMNA,MMP2,SGCB,PTGDS,THBD,TFPI2,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,ALDOA,MAP2K3,MDK,CYR61,ITGA7,mir-21,MAP2K5,ADM,LEP,DDIT3,LEPR,FGF2,BMP2,ADIPOQ,TNFSF10,TNFAIP3,ATF6,INPPL1,HIF1A,CCL3,NGF,IRAK1,PDCD4,ID1,HMOX1,SHC1,NFKBIA,COL6A1,EDN1,STUB1,TIMP1,HSPE1,KIT,ERBB2,NCL,MAPKAPK2,ABCC9,ADRB2,PLAT,AGT,S100A1,ANGPT1,CSK,CSF1R,MT1A,PRMT1,SLK,LIMS1,CAT,XAF1,BNIP3L,SGCD,ADRA1A,MAOA	95	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	epithelial thyroid cancer	epithelial thyroid cancer	7.03E-06	 	 	 	 	PRUNE2,CBX7,TFF3,AXIN1,PTTG1,RTN1,UNC5B,ANKMY1,HRAS,ASCC2,TGFBR2,POR,ITGA3,NUP93,TSC2,TUBA1C,RET,TEK,ETS1,PEX6,SPP1,ADAMTS1,TUBB2A,CLIP2,LAMC3,THRA,MMP2,CRABP1,FLCN,CORO7/CORO7-PAM16,BCL2L1,PKD1,RAP1GAP,LSM7,ZER1,mir-21,SPTBN1,AMY1C (includes others),FCGRT,FLRT1,PKM,CDK4,IDH1,EFNB2,AHNAK,TIMP1,THBS1,SRGAP1,KIT,PRKCE,ARHGEF2,ERBB2,TPO,TMEM132B,GJA4,MAPKAP1,CXCR4,TUBG1,ARHGAP4,AXL,CSF1R,NDUFA13,CLGN,RBM42,S1PR1,PTGS2,ABCC3,KDR,XK,DSG2,MMP9,FCGBP	72	
Post-Translational Modification	phosphorylation	phosphorylation of protein	7.08E-06	Increased	2.252	 	-0.158	CAMK1,CTGF,BMP4,SGK1,AXIN1,TYRO3,CTSG,HRAS,CDKN2C,MST1,CCDC88C,SPI1,ODC1,IP6K3,CCND3,RARA,MYADM,PLXNB2,HIPK2,MATK,CDKN1C,STK36,THY1,FLOT1,GRK5,TNK2,HSPA8,MAP3K12,DVL2,LRRN3,CCND2,BSG,MAP3K20,ADM2,MAP2K3,MAPK7,SQSTM1,CYR61,ANG,PTPRA,PHLPP1,ADM,FYN,NME1,ADAM17,DAPK2,FGF2,GNA11,CDK4,ADIPOQ,CTDSPL,FKBP1A,EFNB2,TADA3,MTOR,CCL8,CCL2,IL34,PRKCE,CD24,DAB2,CSNK2B,ACVR1C,NPRL2,CCR1,STK19,ANGPT1,TYROBP,TRIM28,CSK,SLIT2,RELN,HSPA2,MMD,COL5A3,TF,NTRK3,FAM129A,LYN,FCER1G,DVL3,SOX9,MAP3K8,PIN1,SYN2,FZD7,SOCS3,RARRES2,ADRBK1,SESN2,CD36,CD4,CLIP3,FNIP2,LIPE,TGFBR2,HSPA4,CAMK2D,MAP2K2,BRSK1,GSK3B,RET,BCKDK,BIRC3,TEK,PDK4,PHKG1,HK1,EIF2AK1,CXCL8,MIF,AXIN2,SPP1,MYDGF,STK39,VEGFC,SNRK,DGUOK,ERCC2,PKN1,FLCN,SLC3A2,CDC42BPB,SDCBP,ERP29,ITGAM,SRPK3,DUSP1,PRKCD,IGFBP3,RGN,SYN1,MAP2K5,MAST2,PEBP1,ICK,LEP,ERN1,BMP2,ABL1,NGF,CCL3,CDKN2B,ETV6,PTPRF,IRAK1,EPHB6,CD55,EDN1,THBS1,COQ8A,RPS6KB2,LOC102724428/SIK1,KIT,STK24,NEK7,ERBB2,HCST,MAPKAPK2,CHEK2,PTGER4,PRNP,AGT,SRC,CXCR4,LRRK2,PLAUR,MKNK2,CSF1R,FIZ1,BTK,SLK,NEK11,FASTK,PAG1,CAT,EPHB3,EDNRA,RPS6KA4,KDR,NCKAP1L,MAP4K4,P2RX7,MMP9	184	
Developmental Disorder	growth failure	Growth Failure	7.12E-06	Decreased	-5.155	bias	0.841	DDX11,BMP4,ITSN1,RRM2B,NCSTN,IL6,SLC35C1,SPI1,SKIV2L,POR,IDUA,NR4A3,ITGA3,PEG10,RARA,TSC2,MGP,ATF4,EBF2,HEY2,HIPK2,KAT2A,APEX2,HADHA,ETS1,CDKN1C,STK36,SV2B,C1GALT1C1,MMP2,RAD51D,HAX1,NINJ1,PLAG1,SH3GL1,PYGO2,CDH2,CDH5,ATMIN,CTSB,TFRC,ACACA,MAPK7,SFRP1,ITGA7,NOTCH1,HIST1H1C,RALA,SLC4A2,ZFP36,CRTAP,SIN3B,HEXA,MSRB1,COPS8,G6PC3,EFNB2,TRIB1,MCOLN1,ID1,GADD45GIP1,MTOR,KAT2B,GADD45A,PTS,SLC19A1,STIM1,CSNK2B,PLOD3,LIG3,PLAT,CYP11A1,MYCN,SOX7,SLC25A13,CTSK,EGR1,ZNF521,CUL7,MESP1,GFRA2,TK2,COPS3,SUPV3L1,CBS/CBSL,PROCR,FKBP4,BNIP3L,TP53BP1,PTGS2,MSRA,LIG1,ADRBK1,LAMTOR2,PTTG1,TAF10,GPC3,MYC,TGFBR2,IKBKG,IP6K1,C1QBP,CLCN3,KLF2,TEK,FST,DNASE2,SGCG,ITPR2,LAMA2,MAPK8IP2,LMNA,FZD9,THRA,STX1A,DCHS1,AES,CRHBP,H3F3A/H3F3B,ERCC1,SNX1,IGFBP3,BAP1,COMMD1,VHL,SULF1,SFRP2,ERN1,ANTXR1,PTPMT1,TET1,INPPL1,HIF1A,NGF,ETV6,TMEM119,HMOX1,AEBP1,DHCR7,NFKBIA,SMO,RPS6KB2,ENPP2,NEK7,SULF2,SLC20A1,SRC,PAK4,DHRS3,ATP2C1,SLC12A2,AQP11,SNX27,PSME3,CSF1R,NFE2L1,ITPA,LPAR1,MAP4K4	159	
Cancer, Organismal Injury and Abnormalities	papillary carcinoma	papillary carcinoma	7.24E-06	 	 	 	 	CBX7,TFF3,CMTM4,RGCC,HRAS,ACP5,METAP2,TGFBR2,ACP6,DHTKD1,RET,TEK,PDK4,ETS1,SPP1,ADAMTS1,MFAP5,THRA,MMP2,TFPI2,CRABP1,ABCA8,RAP1GAP,ALDH1A2,TRO,LRP8,LSM7,MAPK7,SFRP1,NOTCH1,mir-21,HIST2H2AA3/HIST2H2AA4,IGFBP4,ADAMTS7,GSTM5,FLRT2,CUBN,TPR,PKM,FKBP1A,HIF1A,COL15A1,IDH1,EPHB6,EFNB2,DTNA,MTOR,TIMP1,THBS1,MCAM,CMTM8,KIT,CD24,PRKCE,DAB2,TPO,RNF144B,CHEK2,ASIP,MAPKAP1,CXCR4,SLIT2,CSF1R,C2orf88,KRT8,ZFPM2,VAV3,S1PR1,LPAR5,TAF1C,SEMA3C,PTGS2,ABCC3,BMP6,KDR,FCGBP,MMP9	77	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	colorectal cancer	colorectal cancer	7.41E-06	Increased	2.424	 	2.690	PCLO,SLC39A8,AJUBA,PPRC1,SMARCB1,WASH3P,ETS1,SRPRA,SLX4,DVL2,CDH5,ALCAM,TRIAP1,RAB40C,BRE,mir-21,LTBP2,GBP1,KIAA1211L,TMEM79,ADIPOQ,MFSD5,MCTS1,SYNM,DIABLO,C1R,RABL6,GPC6,MTSS1L,SLC12A8,RNF157,PAMR1,THNSL2,PDZD2,AFF3,MTHFD1L,KIF7,SWAP70,CBS/CBSL,NDST2,CYP4F11,AKR1C3,HAVCR2,TRPM8,TMEM169,CBX5,INTS1,TSPAN17,CARD8,NDUFA10,NSMAF,TEK,ADAMTS1,GNAZ,GUF1,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,PSME4,C17orf97,RAB11FIP5,RPH3AL,MRPL15,FLRT1,EMX2,HDGF,THYN1,COL6A1,F8,EPN1,NLRP3,TCEA3,PLAUR,FRMD4A,CLEC16A,ACADVL,TXNDC12,FECH,TSC22D1,AP3M2,ING1,MAP4K4,MED24,CTGF,SNTA1,HOMER3,RNF38,ZNF395,PRG4,SPAG8,PNKD,MCL1,PIK3C2B,BIRC7,ATG7,SV2B,CENPB,MT1X,PLEC,FAHD2A,CNOT10,MALSU1,APEH,FAHD2B,CCDC136,MAP3K12,ISLR,EEF2KMT,RSAD1,AKR1C4,NOTCH1,COL3A1,NRP1,CPSF2,SORL1,ZFP36,LEPR,EFHD1,SIN3B,FKBP1A,RUVBL1,CST3,ZNF608,HGS,AHNAK2,LIMCH1,CD209,ANKRD9,STAMBPL1,COL12A1,TRIM28,EGR1,DDX24,NTM,ACLY,COPS3,SBF1,CELF2,PQLC2,PTGS2,FBXW9,CHD7,ARID4A,COBLL1,LHCGR,CLEC3B,ZNF91,MCTP1,FAM193A,FST,EGR3,IRX6,SLC4A7,ATP10A,SLC39A3,LRRC41,COL6A3,DUS1L,FRYL,TOMM34,SCRIB,YIF1A,CDK5RAP2,HIGD1A,ZNF174,MAN1B1,PTPRF,ARHGAP17,MARCH8,THBS1,USP47,ASAP3,SULF2,ZNF493,LRRK2,TANC2,PLSCR4,EMP1,PLEKHH1,PAG1,PLP2,MT1F,SLIT3,NIPA2,HCAR3,SYTL2,MAP6,CACNA1H,ANKRD20A4 (includes others),ATP2A2,MT1E,ODC1,CAAP1,GATAD2A,NUP93,EFHB,ARHGAP39,PLEKHO2,WDR47,ALDH3A1,TSHZ2,MRPL24,NUP43,PDIA5,ALDH1B1,DPT,SOGA1,MTSS1,MFAP5,LAMC3,HAX1,WDR81,NRBP1,SLC7A10,PYGO2,MN1,TMEM41B,ARHGEF6,PHF23,TFRC,CD86,KCNIP4,SQSTM1,BYSL,ZDHHC4,NOL7,SLC4A2,PLXNA3,CUBN,IGSF1,SCUBE2,GDF15,HSD17B11,CDK4,CEBPD,DUSP22,CRAT,TECR,KLHDC9,GADD45GIP1,DUSP5,POFUT2,CCL2,DAB2,ALG8,ADORA1,RAD21,C11orf54,LIG3,SLC38A7,HELZ,GLRX2,STON1,OLFML3,C1orf122,FAM178B,SDF2L1,NTRK3,ARHGDIA,BMPER,TP53BP1,AFG3L2,BMP6,ST3GAL4,CPXM1,ADRA1A,KTN1,ISM1,NOC3L,ABCA3,RTN1,ACO2,TYMP,GPNMB,MYC,TGFBR2,TPRN,ZNF598,GYPE,METTL5,STAB1,SMPDL3A,PFKFB3,ATF3,RILPL1,VEGFC,DCHS1,CDC42BPB,MATN2,SORCS2,C2,PMEPA1,RBP4,MAST2,ERAP2,SPIRE2,SRPX,SCARA5,DENND4B,SLC38A1,NEURL4,GSTT1,SLC2A3,ETV6,HLA-DRB1,TRIM6,AHNAK,TIMP1,MCAM,MEX3B,LOC102724428/SIK1,CIZ1,IARS,SLC20A1,VCAM1,PARVA,RNLS,ST3GAL6,CANX,N4BP1,BSCL2,NFE2L1,SERPINE2,SH3PXD2A,SLK,XYLT2,CLGN,LOC102724788/PRODH,CAT,ISG20,MIB2,SGK1,TRAP1,CDKN2C,HOXA9,NCOA7,SLC4A3,ABR,ZHX2,VEGFD,RIMS3,MMP2,SCNN1D,RAE1,DOCK1,SRGAP3,PPIH,DHRS9,PIP5K1C,C11orf80,MAP3K20,IL10RA,ALDOA,LRP8,BACE2,AIDA,PDGFD,ITGA7,RERGL,FAXDC2,VCAN,TMEM94,MTOR,TADA3,DHPS,SRGAP1,ALDH1A3,PRKCE,ACSL4,COL18A1,PLOD3,PLAT,DNAH6,CYP11A1,SOX7,GSTM1,RRP12,PCDH9,NR2C2AP,STXBP6,POLD1,POMGNT1,TRMT1,P4HTM,CLDN5,RBM6,ZFP36L2,VPS52,MAPRE3,FZD7,MVD,C10orf54,PTPN23,VPS28,COBL,SDAD1,OSR1,TMEM150A,KPNA2,LTBR,CLCN3,MYO10,AGBL5,DDX41,ADRA1B,ACTA1,PTX3,CSF3R,APLNR,SPP1,SGCG,MACROD1,ZNF408,MARS,PANK1,TRAPPC9,RRP7A,THSD7B,COL7A1,AOC3,DRAP1,ADAMTS7,B3GALT6,LEP,PRDX5,HPS6,FLRT2,ANTXR1,UBASH3B,RGS12,ADSL,FLNA,FUBP3,HSD11B2,S100A8,MYO16,PRRT3,TMEM132B,DLGAP4,CPED1,SMAD7,ENO1,DYM,OLFML2B,TANGO2,RDH5,UBA1,ATP6V1B2,MMP9,CARM1,KCNJ2,AXIN1,PPP2R3B,MTG1,IL6,POLRMT,PPP1R14B,EIF3B,CSE1L,AMHR2,AHCY,HEYL,PTOV1,TMEM100,PDLIM7,CTSB,C15orf39,EPHX1,COL4A5,DAPK2,GNA11,ZNF419,GTF3C1,MECOM,KIAA1549L,CDO1,PVR,IGF2R,MYO5A,HNRNPH1,LYN,SOX9,MXRA5,RARRES2,MICALL2,AP1B1,OSCP1,CCT5,KMT5A,CXCL8,STK39,UROS,CBX6,ERCC2,AKR1B10,ADRA2A,SLC7A2,CCDC80,TNS1,VHL,SLC11A1,SULF1,IGFBP4,PLGRKT,DNASE1L3,BMP2,INPPL1,COL6A6,HLA-G,ALDH2,ESPNL,ERBB2,THBS4,SRC,RGS20,COL6A2,ITM2C,COL11A1,PRUNE2,DDX11,TYRO3,PCDH17,GYG2,POMC,PLS3,IRX3,KIF21A,CAPN5,SFRP4,CAPN6,DKC1,ATP8B4,CEP89,JUNB,ROR1,NLRX1,RNASEH2A,BCAP29,NGRN,LARGE1,AAAS,PDE1B,RTN4,AKAP12,SQLE,FYN,BTG3,ATAT1,NAA35,ABCA5,THBS3,EIF4EBP1,ENAH,JUN,ZNF334,CSF2RA,DCXR,MYO1D,FUK,ECM2,PLXNA1,CEP164,NOL6,PTPRK,MYOM2,WDR55,ARHGAP4,PAICS,NBEA,SLIT2,BRMS1,TMEM42,AXL,PLA2G2A,DCAF13,MAMSTR,TM4SF1,LRFN4,TFF3,TNFRSF4,FARP1,FAT1,CD36,CD4,MAP1B,NDUFB10,WDR5,SLC25A6,MYOM1,BCL7C,GPC1,RET,HLA-F,EPB41L1,C7orf50,PTPRE,TRIOBP,PACSIN3,ICA1,HSPA9,PCDHA1,MAPK8IP3,KIAA0922,FLCN,PRSS23,RAP1GAP,PRKCD,RARRES3,CLCN7,CRABP2,SMAP1,SH3RF3,KIAA1191,ATF5,SLC4A11,IPO9,ANGPTL4,HSPE1,SMO,CDCA5,NCL,IFRD1,CHEK2,EMILIN1,PAK4,EPAS1,LRRC2,PCOLCE2,VSIG4,SGTA,PPP1R16A,PRMT1,IL18RAP,COLEC11,NAT8L,CYC1,APOC1,ACAT1,GBE1,NUCB2,GPR160,PDE8B,CPZ,KDR,TNFRSF19,HLA-DOA,KLHDC8B,PAPLN,CTSG,COL8A1,SERPINA3,PLEKHM2,SLC9A1,CLIP1,FADS3,ZNF263,EGR2,IQCC,KEAP1,CEP170B,CAV1,ATF4,STK32A,UNG,TMEM97,PIGT,TM6SF1,SELE,PODN,PPP1R1B,SMG5,ANO6,NPY5R,TFPI2,SHROOM4,ZNF579,HSPA8,EVPL,NRDE2,CTSA,LRRN3,CBLN3,VARS2,FSCN1,MCEE,CCDC178,ITGA1,SAMD4A,FGF2,MMP25,SLC35B2,LAMP3,HS3ST3A1,GRINA,COL16A1,ZMYND19,RANGAP1,TRIM29,FCGR3A/FCGR3B,G3BP2,NINL,ZNF524,TOB1,SLCO2A1,TRIB3,PRDM11,AGL,HSPA2,GLG1,FOS,NRXN2,NR4A2,FLNC,TAF1C,AARS2,NLE1,ABCC3,CSTF3,QPCT,ABCB6,TRAPPC2L,FOXRED1,SESN2,ATP2B1,SLC38A10,PTTG1,MBP,DPP7,POLR3E,KLF6,AP2A2,CLPP,GPR4,FAR2,GCLM,CHTF18,CHMP1A,PDZRN3,KCNJ8,LRBA,DOK2,LAMA2,CAPG,ANO1,OSBPL7,C9orf114,KLF4,SLC3A2,KCNG1,CBX1,ORM1,SOBP,IGFBP3,MEGF8,DOCK6,RUNX1,PCMTD2,TPR,ABCF1,CRYL1,GLRX,GCDH,SHC1,MKL2,ENPP2,LRPPRC,TOX2,LONP1,AGT,PSAT1,SUGP2,SLC22A12,TUBG1,PWWP2B,NQO1,NUP210L,PMP22,PIGB,TACC2,KIF5B,ASTN2,SMG7,IVD,NREP,CADM3,DPYD,C1orf115,APOB,ITSN1,TGFBR3,NCSTN,RAPH1,PCOLCE,NMUR2,GAA,NPTX2,ANK2,EYA2,MATK,CACHD1,CALCRL,PEX6,NDRG1,SLC24A3,TUBB2A,CRABP1,S1PR3,COLEC12,CDH2,CCND2,PTPRB,STIP1,ADAMTS18,GLUL,SFRP1,IFIT2,MYEOV,ADM,MME,HIST1H1C,ADAM17,MSC,PIGO,GRB14,ZNF330,TCEA1,NID2,SRD5A1,WASF3,UHRF1BP1,TNFSF10,XPOT,TTC1,MYH11,RPP40,IDH1,FANCE,COL5A1,EFNB2,SLC2A6,HLCS,SNX10,CLMN,PSMD14,STIM1,SH3GLB2,TPO,KIAA0391,LDLRAP1,RASSF5,PCBP2,PTPRT,PI4KA,MYCN,SEMA3G,STK19,IMPDH2,MGMT,DPAGT1,CYP1B1,B4GALT2,PLEKHG6,TF,S100A9,CDK20,PPP1R16B,NOP2,DENND1A,LSP1,MS4A2,CBX4,NEDD9,FBN2,PHLDA1,ADSSL1,CXCL12,TPM1,TUBB,CEL,TNIP1,CRIP1,BRSK1,SLC7A5,C14orf180,PUF60,PDK4,EIF2AK1,IGFBP6,MIF,AXIN2,TEX2,ST6GALNAC3,PKN1,EFS,PPP2R1A,ITGAM,ERCC1,SMOX,SNX1,EXTL3,PLEKHH3,EPB41L3,PKM,ABL1,RBBP8,CDH23,MRPL2,TET1,SMPD1,GPR34,MYLK,ITGA10,HIF1A,FBXO3,ACOT7,FAM110B,PDCD4,COL1A2,SOX17,NFX1,HMOX1,NKD2,AEBP1,CCL13,KCNMA1,POLN,CLOCK,KIT,NEK7,HCST,CUL9,ALPL,PTGER4,PRNP,MIPEP,TRIP6,ZBTB7C,RAPGEF5,COQ2,ZDHHC7,CCDC3,CPA4,ARHGAP28,CYTIP,DIP2C,LPAR1,JCHAIN,RTN3,DSG2	950	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of phagocytes	7.42E-06	 	0.222	bias	-2.017	RARRES2,CTGF,CTSG,CXCL12,HARS,MST1,IL6,NARS,RHOB,ABCC1,LUM,STAB1,TXN,CXCL8,MIF,CMKLR1,SELE,SPP1,PTGDS,NINJ1,S1PR3,ITGAM,MS4A4A,IL10RA,RTN4,ALCAM,CD86,ITGA1,MDK,CNN2,AOC3,APOE,ADAM17,ABL1,ADIPOQ,MYLK,HIF1A,CCL3,NGF,VCAN,CCL8,CCL2,CCL3L3,TIMP1,FLNA,MCAM,SAA1,KIT,S100A8,MAPKAPK2,PRNP,AGT,CCR1,CD209,VCAM1,NLRP3,EPAS1,ANGPT1,TYROBP,CXCR4,PLAUR,DEFB1,PVR,SLIT2,CSF1R,F11R,COL1A1,SWAP70,LDLR,S100A9,WAS,VAV3,LSP1,S1PR1,PTGS2,KDR,CXCL2,MMP9,QPCT	79	
Digestive System Development and Function, Hepatic System Development and Function, Organ Morphology, Organismal Development	abnormal morphology	abnormal morphology of liver	7.46E-06	 	 	 	 	LIG1,SOCS3,PLIN1,RRM2B,ZFPM1,MST1,IL6,SPI1,TYSND1,IKBKG,MTHFD2,GSK3B,HADHA,MIF,SPP1,LMNA,CTSA,ERCC1,BSG,PKD1,DUSP1,RGN,NAGLU,ESR1,TXNRD2,VHL,COL3A1,SPTBN1,APOE,CFC1/CFC1B,ABL1,CDK4,ADIPOQ,CTHRC1,HEXA,SMPD1,ABCA5,VTI1B,RAMP2,CIAPIN1,SLC19A3,AEBP1,MAN2C1,JUN,GBA,HMGCL,CCR1,SLC20A1,MYCN,NQO1,HYAL1,SNX27,BSCL2,TK2,AGL,IGF2R,NFE2L1,GRN,COL1A1,KRT8,ZFPM2,LDLR,CBS/CBSL,MAN2B1,PTGS2,ZFP36L2,ARID4A	67	
Developmental Disorder	dysgenesis	dysgenesis	7.56E-06	Decreased	-2.986	bias	2.186	SLIT3,DDX11,BMP4,CTGF,PCLO,TGFBR3,RRM2B,POMC,SLC35C1,EIF6,ATP2A2,HOXA9,EMG1,SGPL1,SATB2,ITGA3,EGR2,CCND3,MKX,RARA,TSC2,VEGFD,NABP2,ATF4,EBF2,HEY2,ETS1,CALCRL,CDKN1C,PCSK5,CENPB,MAD2L2,HBEGF,HAX1,MN1,IFT122,CCND2,ATMIN,MAPK7,AKR1C4,NOTCH1,SPTBN1,FYN,APOE,ADAM17,ZFP36,TCEA1,FGF2,CFC1/CFC1B,GNA11,CDK4,CTHRC1,VTI1B,MAFG,ID1,JUN,ALDH1A3,RASSF5,GNG5,CYP51A1,HEY1,MBOAT7,CYP11A1,MYCN,MECOM,TWNK,RELN,ID3,POLD1,CSTB,CYP1B1,LAMP2,ZFPM2,LDLR,WAS,SPRY2,LYN,ARHGDIA,SOX9,CBX4,TP53BP1,PTGS2,NEDD9,ARID4A,LIG1,ADRBK1,PTTG1,ITGB1BP1,MAP1B,LHCGR,GPC3,CLPP,MYC,CTSD,CYP26B1,TNIP1,GPR4,EXOSC3,TSEN54,RET,CHMP1A,DNASE2,PKP2,LAMA2,LMNA,VEGFC,HARS2,FOXC1,KLF4,ERCC1,PKD1,ALDH1A2,ESR1,TXNRD2,CDK5RAP2,RBP4,RUNX1,LOX,NFIX,ERN1,ABL1,EMX2,NGF,PTPRF,HMOX1,SHC1,EDN1,STUB1,THBS1,MKL2,ERBB2,KCTD1,AGT,SLC20A1,SRC,DHRS3,SNRPB,NQO1,ITPA,PBX3,CYTIP,EDNRA,RPS6KA4,MMP9	144	
Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism	metabolism	metabolism of terpenoid	7.69E-06	 	0.841	 	-0.649	CH25H,RARRES2,APOB,BMP4,AKR1C3,LHCGR,CACNA1H,LIPE,POMC,ABCG1,IL6,HSD17B8,POR,CEL,CYP26B1,SGPL1,ALDH1A1,RARA,COMT,CAV1,LSS,PTGIS,CXCL8,ATF3,MSMO1,MMP2,AKR1B10,HSPA8,STC1,DHRS9,ALDH1A2,PLTP,CRABP2,AKR1C4,ESR1,RBP4,DHRS4,ADM,APOE,IGFBP4,SQLE,SCAP,LEP,SRD5A1,LEPR,FGF2,BMP2,DPM2,ADH1C,TNFSF10,TNFRSF12A,DHCR7,EDN1,TIPARP,ALDH1A3,DKK3,KCNMA1,SAA1,HSD11B2,CYP51A1,CYP2R1,AGT,CYP11A1,DHRS3,CYP27A1,HDC,G6PD,DPAGT1,ACLY,CYP1B1,ENO1,LDLR,DHCR24,CAT,NR5A2,FECH,RDH5,BMP6,RBP5,MMP9,CYP2C8,HSD17B14,MAOA	83	
Gene Expression	binding	binding of DNA	7.72E-06	 	0.726	 	-0.501	GFPT1,CTGF,ELANE,HRAS,POMC,IL6,PPP4C,SPI1,HOXA9,POR,SATB2,EGR2,BCAT2,RARA,KEAP1,CAV1,TXN,HEY2,HIPK2,ETS1,PPP1R1B,OLFM2,CIDEC,MAD2L2,HBEGF,RPA1,MBD2,IER3,HMGA1,JUNB,BRF2,BTG2,GAPDH,NOTCH1,NME1,GSTM5,DDIT3,FGF2,ADIPOQ,CEBPD,TNFSF10,MYH11,MEOX2,ID1,JUN,KAT2B,CSF2RA,IL17D,SOCS2,MEG3,PRKCE,RAD21,HEY1,MYCN,TRIM28,MGMT,EGR1,HDC,TRIB3,ID3,NR2C2AP,CYP1B1,FOS,HP,NR4A2,TF,PELI1,LYN,TAGLN,S1PR1,NR5A2,SOX9,PIN1,BMP6,SOCS3,TFF3,PTTG1,CD4,HAVCR2,HSPA1A/HSPA1B,CXCL12,RGCC,CEBPG,MYC,IKBKG,RHOB,ETS2,CARD8,GSK3B,LTBR,CXCL8,MIF,SPP1,ATF3,LMNA,THRA,TXNRD1,PKN1,LMCD1,FOSB,CBX1,ITGAM,H3F3A/H3F3B,PRKCD,IGFBP3,ESR1,TEF,RUNX1,LOX,SFTPD,LEP,BMP2,ABL1,TNFAIP3,IRF3,HIF1A,NGF,GLRX,ETV6,NFKBIA,EDN1,NR2F6,ERBB2,NCL,MAPKAPK2,ADRB2,AGT,SRC,VCAM1,EPAS1,CXCR4,SMAD7,ZBTB7C,NFKBIZ,PSME3,BTK,EBF1,CAT,KDR,CARM1	140	
Connective Tissue Development and Function, Tissue Morphology	quantity	quantity of connective tissue	8.24E-06	 	0.436	 	-0.730	GFPT1,PLIN1,CTGF,APOB,BMP4,MAF,HRAS,POMC,IL6,EIF6,GTF2IRD1,IDUA,SGPL1,LGMN,EGR2,NMUR2,CCND3,CAV1,ATF4,IRS2,APEX2,CERS6,RBM38,CLEC4G,SELE,DPT,ATG7,CIDEC,MMP2,JUNB,CREB5,RAE1,CCND2,NPR3,GAMT,EPB42,PPP1R15A,TFRC,SFRP1,SQSTM1,SAC3D1,NOTCH1,APOE,LEPR,FGF2,SIN3B,GDF15,CEBPD,CDK4,ADIPOQ,TNFSF10,MEOX2,EIF4EBP1,TGM2,ID1,MTOR,CES1,JUN,CCL2,PLIN2,STARD13,PRKCE,CTSK,C5AR1,UCP2,TYROBP,EGR1,ZNF521,HDC,DGAT2,TOB1,IGF2R,FOS,COL5A3,LDLR,WAS,GPBAR1,SPRY2,ATP1A2,LYN,S1PR1,BNIP3L,ZFP36L2,ARID4A,LIG1,SOCS3,ITGB1BP1,LIPE,HSPA5,MYC,TGFBR2,ALDH1A1,COMT,CXCL14,LTBR,KLF2,ACTA1,PDK4,STX11,EIF2AK1,CXCL8,SPP1,DNASE2,ADAMTS1,DOK2,LMNA,FZD9,THRA,KLF4,FOSB,STC1,BCL2L1,ITGAM,ERCC1,ADRA2A,DUSP1,IGFBP3,CD14,CLCN7,ESR1,CCDC80,VHL,RUNX1,LEP,ABL1,SLC7A1,CIAPIN1,HMOX1,AEBP1,ANGPTL4,AHNAK,CSPG4,FNDC5,HSD11B2,HCST,ALPL,ADRB2,ASIP,AGT,SLC20A1,CD59,EPAS1,LCLAT1,SLC12A2,NQO1,F13A1,BSCL2,NFE2L1,COL1A1,CIDEA,EBF1,CAPNS1,ACADVL,LPAR1,SPARC,KDR,P2RX7,MMP9,CLEC10A	159	
Neurological Disease	syndromic encephalopathy	syndromic encephalopathy	8.24E-06	 	 	 	 	EIF3C,METTL22,HACD1,MBP,RRM2B,TSPAN13,SERPINA3,TYMP,DNAJC15,CEP104,RHOB,SMARCB1,TSC2,TXN,ECHDC1,TACO1,HADHA,ADRA1B,PTGIS,GRK5,RNASEH2A,WDR81,TAF9B,HLA-DRB4,CCND2,ADRA2A,CORO1B,RTN4,RNASEH2C,DNAJB6,VHL,B9D1,ADM,ERAP2,TMEM138,TCTN1,DDIT3,SERAC1,ST6GALNAC4,FKBP1A,SLC52A2,EIF4EBP1,IDH1,HMOX1,SUCLA2,MTOR,ENPP2,PIK3R2,LONP1,CHEK2,ADRB2,BEX2,GSTM1,PERP,RELN,SERPINE2,ADGRG1,PMP22,KIF7,DHCR24,SLC25A19,FCER1G,ADRA1A,COX15	64	
Skeletal and Muscular Disorders	laminopathy	laminopathy	8.45E-06	 	 	 	 	LOX,FHL1,TGFBR3,HIF1A,TAX1BP3,TGFBR2,COL1A2,COL5A1,PLS3,COL6A1,DAB2,TBCD,EMILIN1,COL5A2,NBAS,COL6A2,TUBB2A,EMD,LMNA,ACLY,CYB561,COL1A1,COLEC12,SDCBP,COL6A3,SERPINH1,CELF2,S1PR1,BNIP3L,SPARC,RSU1,COL3A1	32	
Cellular Growth and Proliferation	colony formation	colony formation of tumor cell lines	8.48E-06	 	0.120	 	0.145	VPS28,HSPA1A/HSPA1B,KLF6,TYRO3,IL6,BIN1,MYC,CTSD,ALDH1A1,SMARCB1,TSC2,LUM,NUPR1,CAV1,DNAJA3,KPNA2,ETS1,BIRC7,ATG7,SPP1,ATF3,NDRG1,MT1X,THRA,HMGA1,KLF4,RASD1,BCL2L1,CCNG2,IGFBP3,CTSB,MDK,SQSTM1,CYR61,ESR1,NOTCH1,LOX,IGFBP4,ADAM17,GADD45B,EPB41L3,FGF2,ADIPOQ,TNFSF10,IRF3,HIF1A,VCAN,HDGF,DIABLO,ID1,NFKBIA,JUN,EDN1,GADD45A,CCL2,MCAM,KIT,TRIT1,SH3GLB2,ERBB2,RASSF5,SEMA3B,HCAR2,S100A1,SRC,EPAS1,MECOM,SPRY1,EGR1,SMAD7,SERTAD1,GRN,FOS,RCAN1,ENO1,KRT8,LMO3,SPRY2,PEA15,SPARC,PTGS2	81	
Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development	proliferation	proliferation of neuronal cells	8.58E-06	Increased	2.452	 	-0.167	CAMK1,BMP4,SGK1,HRAS,IL6,RAPH1,SLC9A1,ITGA3,GNA15,IRX3,TSC2,CAV1,DLG4,DNAJA3,PLXNB2,TXN,TESK1,MATK,RND2,RIMS3,CHN1,PRAG1,GRK5,MMP2,TNK2,NINJ1,DOCK1,DVL2,SRGAP3,CDH2,NR1D1,RTN4,ITGA1,MAPK7,NOTCH1,PTPRA,NRP1,SPTBN1,APOE,ADAM17,PLXNA3,FGF2,BTG3,DCLK1,VTI1B,VCAN,EIF4EBP1,TGM2,EFNB2,ID1,MTOR,JUN,SRGAP1,SOCS2,PLAT,PRPH,PLXNA1,ANGPT1,EGR1,GFRA2,SLIT2,RELN,ID3,GRN,NTRK3,SPRY2,FKBP4,MAP3K8,BMP6,ID4,MAOA,MT2A,SOCS3,NCDN,MICALL2,POLR3E,MAP1B,CXCL12,TGFBR2,BRSK1,GSK3B,NEDD4L,RET,MYO10,RTN4R,EGR3,LAMA2,RIMS4,IRX6,VEGFC,FZD9,CORO1B,RAP1GAP,PRKCD,SNX1,EXTL3,MDK,MEGF8,ESR1,SYN1,ETV5,DOK5,FAM107A,LEP,NFIX,NLGN1,BMP2,VAPA,ABL1,HIF1A,NGF,PTPRF,TNFRSF12A,SHC1,NFKBIA,ARHGAP17,STUB1,THBS1,MARCH8,DUSP10,USP47,SMO,KIT,ENPP2,NSMF,ERBB2,PRNP,SRC,VCAM1,PAK4,EPN1,RTKN,SLC12A2,LRRK2,ZPR1,FAIM,SERPINE2,KIF2A,LPAR1,EXOC4,CAT,EPHB3,FECH,GAP43,ELK1,DNM1L,TNFRSF19,MMP9	148	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	glioblastoma cancer	glioblastoma cancer	8.70E-06	 	 	 	 	SERPINI1,PTTG1,MBP,KLF6,CDKN2C,HSPA5,ATP2A2,GPNMB,MYC,TGFBR2,KCNAB1,AJUBA,MGP,CAV1,GOT1,GSK3B,RET,HIPK2,TSHZ2,PTX3,PFKFB3,AXIN2,SPP1,LHPP,EGR3,PTGDS,MBD2,GSR,DOCK1,DVL2,ABCA8,CCND2,H3F3A/H3F3B,BAP1,ALCAM,RSU1,mir-21,COL3A1,AKAP12,HIST2H2AA3/HIST2H2AA4,MAP7,HIST1H1C,PA2G4,GBP1,BCL2L12,PKM,ABL1,CDK4,IDH1,COL1A2,EPHB6,SOX17,DTNA,MTOR,TIMP1,CSPG4,FLNA,KCNMA1,KIT,ENPP2,ERBB2,RAD21,ACTN1,CHEK2,SRC,VCAM1,MECOM,MGMT,SLC12A2,LRRK2,RAPGEF5,NBEA,RELN,ID3,HSPA2,CXCL16,COL1A1,TF,LPAR1,VAV3,SOX9,GAP43,TAZ,ELK1,KDR,MAP4K4,MMP9	87	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	follicular thyroid tumor	follicular thyroid tumor	8.83E-06	 	 	 	 	PTTG1,HRAS,IDH1,EFNB2,SRGAP1,THBS1,TIMP1,ANXA5,DAP3,KIT,ERBB2,TPO,RET,TEK,ETS1,SPP1,ADAMTS1,MMP2,THRA,CSF1R,NDUFA13,CTSB,S1PR1,PTGS2,KDR,MMP9,RBP4	27	
Cellular Function and Maintenance	internalization	internalization of tumor cell lines	9.40E-06	 	1.913	bias	0.388	PTX3,CD209,RALA,PFN1,CSK,CXCL12,RGCC,IL6,AXL,SPI1,CLIP1,TGM2,MYC,BTK,HMOX1,ITGAM,RRAS2,PLEKHG6,ETS2,WAS,PRKCD,PELI1,LYN,PRKCE,FZD5,NCL,KLF2,P2RX7,MARCO	29	
Dermatological Diseases and Conditions, Inflammatory Disease	acne	Acne	9.54E-06	 	 	 	 	MME,CCR1,CXCL8,SELE,VCAM1,SGK1,SRD5A1,G6PD,THY1,PLAUR,MMP2,DEFB1,SAA2,CD163,NGF,AKR1B10,ODC1,PLA2G2A,LYZ,CRHBP,JUN,S100A9,TIMP1,RARA,CAT,CD14,SOX9,PTGS2,CXCL2,MMP9,COL3A1	31	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	renal cancer	renal cancer	9.62E-06	 	-0.078	 	0.043	CBX7,PCLO,VAC14,TPRG1,NPL,SLC39A8,POR,UPK3BL,GLB1,AJUBA,KEAP1,SMARCB1,ARHGAP39,TSC2,CAV1,DEFB132,PIGT,WASH3P,TSHZ2,PTGIS,SLC2A5,STK36,PPP1R1B,RANBP3,LARP4,PTPN3,IFNAR2,SHROOM4,NRDE2,PDLIM7,CDH5,BTG2,GCC1,ZDHHC1,KIAA1217,EPHX1,CD163L1,NME1,PSMD7,FGF2,OSGIN1,IGSF1,CUBN,CTDSPL,POFUT2,CCL2,ARFGAP1,PLIN2,IL34,ADORA1,CYP51A1,ALDH5A1,CCR1,S100A1,MECOM,TJP1,DGAT2,FOS,ARHGEF5,HNRNPH1,FLNC,ATP1A2,TAF1C,SOX9,MAP3K8,BMP6,RBP5,C11orf68,HAGH,ARSD,SESN2,ATP2B1,ABCA3,KLF6,DIRAS1,INTS1,GPC3,MYC,TGFBR2,LHFPL2,RHOB,MOCOS,TUBA1C,TEK,MARCO,CXCL8,LRBA,H19,MAST4,RILPL1,LAMA2,VEGFC,ERCC2,DCHS1,GUF1,FAAP20,BCL2L1,RPL8,AEBP2,BAP1,C17orf97,ESR1,VHL,S100P,SUN1,PTGFR,SLC1A4,RPH3AL,GSTT1,HNRNPK,IRAK1,RPL14,POLR1C,HLA-DRB1,AHNAK,TIMP1,SAA1,ERBB2,NUSAP1,TUBG1,G6PD,GNAI1,PLAUR,PYGB,CXCL16,RRAS2,POLR3B,SMG7,CDC34,CXCL2,NNAT,PRUNE2,DDX11,SLC29A4,MSRB2,PCDH17,CDKN2C,ZNF605,KIF21A,ANK2,PIK3C2B,CALCRL,NANOS1,ZC3HC1,CENPB,TUBB2A,MMP2,THBD,FAHD2B,RAE1,SH3GL1,CCDC136,AQP9,SRGAP3,CCZ1/CCZ1B,TIMP4,CCND2,BSG,EPB42,NPRL3,IL10RA,TRO,CCT3,RPL6,RSU1,MAP2K3,ALAS2,MAPK7,SFRP1,AIDA,CYR61,TMEM158,NOTCH1,PHLPP1,ADM,MME,SPTBN1,HIST1H1C,ADAM17,RALA,SERAC1,BTG3,TNFSF10,XPOT,FKBP1A,TBL3,ATP6AP1,IDH1,TRIB1,CADM2,MTOR,ANXA5,COL22A1,PRKCE,PTPRT,AHNAK2,NPRL2,MYCN,PLXNA1,GSTM1,CD276,MGMT,DEFB1,SLIT2,AXL,GABRE,TRMT12,MRPL51,COL5A3,KRT8,LMO3,MCM2,PPP1R16B,SBF1,NOP2,BNIP3L,GABARAP,ATAD3A,ZFP36L2,FBN2,RGS1,SPNS1,CLEC3B,XPO5,SLC35F1,TPM1,TUBB,GUSB,METAP2,GSPT1,ETS2,ASXL2,ACP6,MCTP1,SIAH2,RET,FAM65B,PDK4,MFSD3,AXIN2,ACSL3,TRIOBP,NUP155,EGR3,NDUFAF2,INHBB,FLCN,PANK1,PPP2R1A,SMOX,RAP1GAP,PRKCD,RGN,LMAN2L,XPNPEP1,TMOD1,CDK5RAP2,MAP2K5,RNPEP,ADAMTS7,PKM,ABL1,CDH23,HIF1A,ACOT7,FAM110B,EPHB6,HMOX1,NFKBIA,PCK2,CSPG4,THBS1,FLNA,KCNMA1,FUBP3,KIT,ASAP3,CUL9,ZNF493,CHEK2,ASIP,TMEM132B,FAAH,LXN,SNAPC4,FRMD1,TPST2,SMAD7,LRRK2,ZBTB7C,NFKBIZ,CSF1R,TSPAN1,ACAT1,GLMP,KDR,XK,SLC47A1,MMP9,DHRS7B	300	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	Lymphocyte migration	9.86E-06	 	-0.516	bias	-2.918	RGS1,SOCS3,RARRES2,TNFRSF4,CD4,SPHK2,FCER1A,CTSG,CXCL12,HRAS,HARS,IL6,TGFBR2,CYP26B1,SGPL1,ITGA3,IKBKG,EGR2,ABCC1,MYADM,STAB1,LTBR,FAM65B,KLF2,ETS1,TNFRSF21,FERMT3,CXCL8,MIF,CMKLR1,SELE,SPP1,PLEC,S1PR3,EFS,PIP5K1C,RAP1GAP,CD86,ITGA1,MAPK7,CCL18,NOTCH1,PTPRA,AOC3,RUNX1,FYN,ADAM17,LEP,ACKR2,HYOU1,SMPD1,MYLK,CCL3,ETV6,TGM2,HLA-G,JUN,CCL8,CCL2,CCL3L3,TIMP1,THBS1,MCAM,SAA1,SOS1,ENPP2,ERBB2,RASSF5,AGT,CCR1,CD209,VCAM1,NLRP3,CXCR4,CD69,HDC,RGS16,DEFB1,PVR,TNFRSF14,GPR183,BTK,FOS,CXCL16,COL1A1,F11R,LDLR,SWAP70,CYTIP,WAS,PELI1,S1PR1,PROCR,SPARC,C6,P2RX7	96	
Cellular Function and Maintenance	Clathrin mediated endocytosis	Clathrin mediated endocytosis	1.04E-05	Increased	3.227	bias	1.139	EPN1,AP2M1,ATP6V1D,SHARPIN,CANX,RPS21,LRRC29,AP2A2,ATP6AP1,SF3B3,HAX1,AP2S1,ASB1,NKAP,ATP6V1E1,SRSF3,ASGR1,ATP6V1F,PIP5K1C,NAA60,DAB2,ERBB2,ADORA1,EPB41L2,ATP6V1B2	25	
Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	liver tumor	liver tumor	1.04E-05	 	-0.206	 	0.241	PCLO,ASS1,GARS,TLE1,LRRN4CL,SLC39A8,POR,GLB1,PPRC1,TSC2,VIT,RBM38,DDIT4,SLX4,DVL2,CDH5,ALCAM,ATG101,KIAA1217,mir-21,FHL1,LTBP2,DDIT3,SLC1A5,KIAA1211L,TMEM79,C1R,TIPARP,LLGL1,ATN1,MTSS1L,RNF157,ID3,PAMR1,GPR183,PDZD2,GPAM,MTHFD1L,AFF3,WDR86,TBC1D8,TCTEX1D2,CA4,HAVCR2,DNAJC15,INTS1,LHFPL2,STRN4,STC2,EEF1E1,NDUFA10,MTMR2,NSMAF,TEK,RASGRP2,ADAMTS1,KANK1,BCL2L1,H3F3A/H3F3B,NAGLU,SUN1,ETV5,CARS,KCNK3,ZNF252P,NHP2,CLUAP1,GIMAP6,THYN1,COL6A1,F8,C16orf59,IGSF8,ELMOD3,FAAP100,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,BTK,ACADVL,ZNF544,SPARC,ING1,MED24,MAP4K4,RER1,ASPSCR1,SNTA1,CA12,ABHD1,RNF38,SGPL1,TMEM268,PRG4,ZNF605,SPAG8,FAM124B,POLR2I,PPIL6,UBXN6,CDKN1C,NAB1,SV2B,HIGD1B,TIMM17B,PLEC,CREB5,FAM193B,IRX5,MS4A14,NCLN,KIAA0368,NOTCH1,EOGT,SORL1,SUSD2,FCGRT,ABI3BP,LEPR,ZNF234,NQO2,SIN3B,ST6GALNAC4,FKBP1A,COASY,CADM2,ENTPD6,DIP2B,DPCD,TUB,COL22A1,TXNL1,PI16,HGS,AHNAK2,LIMCH1,RPS24,NAP1L4,CD276,FCRLB,STAMBPL1,COL12A1,TRIM28,DAAM1,MED30,RELN,ACLY,DHCR24,CYP4F22,SBF1,KLHL35,CELF2,TMEM63B,PTGS2,AOX1,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,FAM127B,ZNF91,SLC6A16,RSPO3,CNDP2,IKBKG,PLCE1,DHTKD1,COMT,MCTP1,NMNAT2,GOT1,FAM193A,USP36,FAM45A,SLC4A7,ATP10A,ALAD,PAWR,GALNT13,INHBB,COL6A3,FRYL,SCRIB,TSTD1,RCE1,UVRAG,FPR3,PPIP5K1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,CYGB,SULF2,ASAP3,TMEM104,PARP10,TANC2,LRRK2,DAAM2,ANO2,SYBU,COL1A1,FAF1,PAG1,FAM46A,NCKAP1L,MYPOP,XK,MPV17,SLIT3,SVEP1,SYTL2,CLSTN2,CCDC88C,ASCC2,SLC35C1,ATP2A2,ODC1,RNASE4,CAAP1,NPL,RCL1,OGFOD3,PPP1R3F,GPRC5C,MYADM,WDR47,SPATA18,MRPL24,PLD3,MTSS1,TIMM44,TMEM98,CARMIL1,LAMC3,OSGIN2,SMOC2,WDR81,SLC7A10,MN1,PPOX,PPP1R15A,P2RX6,CHD1L,SQSTM1,ADIPOR2,IGSF10,PTPRA,TRAPPC5,FKBP2,RNF10,APOE,NME1,TTLL3,FBXO10,SFXN4,ZNF205,CUBN,IGSF1,SCUBE2,HS2ST1,CDK4,CTHRC1,CCL2,ARFGAP1,ALG8,ASPH,ARMCX1,RAD21,CYP51A1,CCR1,BTNL9,S100A1,HELZ,TJP1,STOML1,DGAT2,PTCD1,SAA4,TBC1D13,UBL7,MYOC,ZFPM2,LDLR,NTRK3,ARHGDIA,BMP6,CPXM1,PPIL1,ID4,HAGH,KTN1,MEGF9,ABCA3,RTN1,ACO2,TYMP,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GDE1,GYPE,NUPR1,STAB1,LILRB5,KIF25,RPAP1,NBAS,TEX264,FMO2,STARD5,ZNF282,VEGFC,THRA,KCNK12,DCHS1,SMUG1,CDC42BPB,TLN2,ABCA8,CHURC1,LRRC25,VPS37A,ESR1,LRRC47,PMEPA1,MAST2,PTGFR,ERAP2,SLC1A4,CDC20,SRPX,SCARA5,MECR,ZSWIM3,NEURL4,GSTT1,VPS4A,SLC2A3,IRAK1,AHNAK,TIMP1,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,ATP13A2,VCAM1,NUSAP1,AP1S2,XRN2,GNAI1,ZFPL1,BSCL2,PSME3,ATIC,NFE2L1,FAIM,SH3PXD2A,SLK,XYLT2,PHF19,VAV3,TBC1D7,GAPVD1,SGK1,SH3GLB1,PCDH7,NCOA7,SLC4A3,CLCNKA,ABCC1,RPS2,ALPK1,TMEM9B,NAT10,SERINC1,MMP2,SCNN1D,LONP2,UBQLN4,DOCK1,SRGAP3,YARS,TRO,RPL6,LRP8,PDGFD,ITGA7,ALDH4A1,RALA,PDDC1,NT5C,PFKL,VCAN,SERTAD4,DCLK2,TRIB1,MTOR,WDFY1,ALDH1A3,DAP3,NAALAD2,EPS15L1,AKR1B15,LPP,SARS,COL18A1,NCKIPSD,PLOD3,DNAH6,CYP11A1,SOX7,GSTM1,CCDC130,EPB41L4B,PCDH9,POLD1,RBM6,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,CYP2C8,FZD7,MVD,CYTOR,FNIP2,DYNLT1,COBL,CCNL1,TMED5,MBNL3,LARS,PRND,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,DDX41,PTX3,MGRN1,SPP1,SGCG,ITPR2,LMNA,MYOF,MARS,DPP9,GSR,TRAPPC9,R3HDM4,RGN,THSD7B,RNPEP,COL7A1,LEP,FLRT2,C1QTNF1,BCL2L12,UBASH3B,PNMAL1,RGS12,RAMP2,AADAC,FLNA,HSD11B2,ZNHIT2,RNF144B,MYO16,TMEM132B,SNAPC4,SPOCD1,FRMD1,PHOSPHO2,AP3D1,VWCE,CSF1R,TRMT61A,LRP1B,OLFML2B,NDNF,ZNF585A,MMP9,CARM1,CBX7,TOMM40L,RPE,AXIN1,TPRG1,IL6,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,TMEM219,TNFRSF21,SLC2A5,COMP,COCH,TMEM203,GFM1,ERICH1,PTPN3,PTOV1,EPHX1,CD163L1,EVA1B,COL4A5,HSDL1,DDX3X,SPON1,DTNA,ABCC9,GTF3C1,UCP2,MECOM,KIAA1549L,ZNF521,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,SOCS3,ARSD,ANKMY1,FCER1A,ZFPM1,AP1B1,GPC3,CEP104,CTSD,TSEN15,ARHGAP20,ACTG2,KMT5A,ELN,CXCL8,NOX4,STXBP1,MAPK8IP2,CBX6,RIMS4,H6PD,FIG4,AKR1B10,TXNRD1,FCN3,ADRA2A,CCDC80,GSDMC,TNS1,SLC11A1,VHL,SULF1,PC,COL6A6,ALDH2,DHCR7,SNX16,ERBB2,NDUFV1,PKP1,COL6A2,IPO4,G6PD,AP3B2,POLR3B,COL11A1,PRUNE2,KCND2,RAN,PCDH17,MST1,GHITM,NR4A3,EVI5L,LGMN,MKX,RARA,BAALC,KIF21A,MED16,HADHA,ZC3HC1,DKC1,MBD2,ROR1,VPS26B,BCAP29,TSR3,FARSA,AAAS,GAMT,EPB42,PDE1B,FAM71E1,RTN4,ME2,ANG,AKAP12,SQLE,HEATR1,PPP1R3C,SLC1A3,HYOU1,GOLGA3,ATAT1,TRPT1,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,GPIHBP1,TIGD5,C20orf96,ENAH,CELF1,RPUSD3,CES1,JUN,PDE3B,CD24,MORN4,PLXNA1,CEP164,NOL6,PTPRK,ARHGAP4,LRSAM1,PAICS,NBEA,SLIT2,AXL,MRPS18A,GABRE,GBP4,SLC48A1,RHBDD2,GTPBP3,BRINP2,GALE,ANXA3,CILP,NENF,PFN1,FARP1,FAT1,LAMTOR2,CD36,UNC5B,MAP1B,WDR5,CAMK2D,MYOM1,PCYT2,AMPH,GSK3B,RET,HLA-F,EPB41L1,C7orf50,MFSD3,PHACTR3,STX11,HK1,FERMT3,PTPRE,HNMT,TRIOBP,ICA1,PCDHA1,MAPK8IP3,GPAA1,ZNHIT1,FLCN,KIAA0922,RAP1GAP,EXOSC4,RARRES3,IDO1,TBC1D16,XPNPEP1,ARL2,SPIRE1,SRM,SH3RF3,PA2G4,ATF5,SLC4A11,SMO,CFB,STK24,IFRD1,NCL,ATP5I,CHEK2,RHBDD3,COL5A2,METTL1,VSIG4,CIART,TMEM2,GLMP,GBE1,NUCB2,KDR,DHRS7B,KLHDC8B,ANKRD35,WBSCR22,CLIP1,ADCK1,EIF4EBP3,IQCC,KIF1A,KEAP1,ST6GALNAC2,KANK3,HES6,HIPK2,TM6SF1,STK36,PPP1R1B,TMEM201,ANO6,SMG5,MASP1,NPY5R,IFNAR2,TFPI2,HSPA8,TMEM127,CARD9,EVPL,IFT122,CTSA,VARS2,CCDC178,ITGA1,TULP3,MUSTN1,SAMD4A,CHCHD10,OSGIN1,FGF2,SEMA6A,THOC3,ZBTB9,MMP25,SLC35B2,COL16A1,TGM2,CHDH,GADD45A,SORBS1,OSBPL11,CSNK2B,PIK3R2,MAPKAP1,NINL,TOB1,GLG1,FOS,PLA2G4A,HP,SELM,NRXN2,FLNC,ATP1A2,MBD3,ZCWPW1,SLC22A18,TMEM177,TTYH3,SEMA3C,ABCC3,C11orf68,PTER,ABCB6,MT2A,FOXRED1,ATP13A1,PTTG1,MBP,ABCG1,HSPA5,AP2A2,PADI4,GPR4,KCNAB1,FAR2,CHTF18,CAST,PDZRN3,KCNJ8,MAST4,LAMA2,ENKD1,CAPG,OSBPL7,CYB561,KCNG1,ALG3,SOBP,IGFBP3,AGAP3,MEGF8,TXNRD2,PPAN,LRRC8B,UBXN1,NMT1,TPR,CADPS2,ATF6,KIFC2,HNRNPK,REXO2,MSRB3,SHC1,NET1,ENPP4,MKL2,ENPP2,LRPPRC,MCRS1,MRPL40,LONP1,AGT,ZNF135,ZNF358,NQO1,TUBGCP2,ADGRG1,PIGB,TACC2,KIF5B,ASTN2,HEPACAM,NOP16,SMG7,IVD,DNM1L,PNPLA6,COQ9,SLC29A4,CADM3,APOB,WDR45,HRAS,MYRIP,DGCR6L,PEG10,PEX16,CCNB1IP1,ANK2,REEP2,IRS2,TXN,EYA2,ARHGEF4,CALCRL,NDRG1,PCSK5,RRBP1,THY1,TNK2,FAM129B,PLOD1,CTPS1,LDOC1,NR1D1,BSG,PTPRB,CDRT1,ADAMTS18,GLUL,MAP2K3,ZER1,SFRP1,CYR61,MME,SPTBN1,ADAM17,MSC,GRB14,NID2,UHRF1BP1,TNFSF10,TTC1,DCLK1,RPP40,IDH1,UCHL1,COL5A1,EFNB2,PTS,STARD13,CLMN,PSMD14,KIAA0391,LDLRAP1,RASSF5,LBP,PCBP2,PTPRT,AMFR,PI4KA,MYH1,STK19,VPS18,ADRM1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,WDR12,CYP1B1,RHPN2,KRT8,PLEKHG6,TF,PPP1R16B,CNN1,ADCY1,DENND1A,ZSCAN18,S1PR1,CBX4,FBN2,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,DCAKD,TFG,SPHK2,CXCL12,SDC4,DCAF10,FRMD3,CCT8,PLEKHG4,PARVB,TNIP1,SDPR,BRSK1,SLC7A5,PUF60,PDK4,EIF2AK1,PNMA2,AXIN2,TMIE,TEX2,SNRK,PKN1,EPRS,LMCD1,EFS,PPP2R1A,ITGAM,SMOX,GNL3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,SLC7A1,TET1,QPRT,MYLK,ITGA10,SIL1,HIF1A,ACOT7,CDKN2B,FAM110B,PRKCSH,COL1A2,SEPHS2,NFX1,HMOX1,NKD2,AEBP1,PCK2,KCNMA1,C7,POLN,KIT,ARHGEF2,NR2F6,CUL9,ALPL,STK40,HMGCS1,ACTN1,PRNP,CYP27A1,CXCR4,COPS7A,SCIN,ZBTB7C,SLC7A8,CCDC3,WARS,DIP2C,LPAR1,EDNRA,ELK1,RTN3	1035	
Cardiovascular Disease, Developmental Disorder, Organismal Injury and Abnormalities	hypertrophy	hypertrophy of heart	1.06E-05	 	0.088	 	0.431	KCND2,CTGF,PFN1,BMP4,PFKFB1,CD36,CACNA1H,CXCL12,HRAS,TPM1,IL6,SLC9A1,ATP2A2,GPX3,NR4A3,CTSD,CAMK2D,PLCE1,MYOM1,GAA,PNKD,CAV1,TXN,GSK3B,ACTG2,HEY2,CASQ2,ELN,NOX4,MIF,CMKLR1,ATF3,NAB1,GUCY1A3,HBEGF,GRK5,HMGA1,IER3,KLF4,LMCD1,ADRA2A,DUSP1,PRKCD,CTSB,MAP2K3,MAPK7,mir-21,MAP2K5,RBP4,ADM,APOE,ADAM17,LEP,LEPR,FGF2,GNA11,GDF15,ADIPOQ,FKBP1A,TNFAIP3,HIF1A,H2AFZ,EIF4EBP1,HMOX1,SHC1,DUSP5,MTOR,NFKBIA,JUN,EDN1,RGS5,TIMP1,PRKCE,ADORA1,ADRB2,PLAT,AGT,EPAS1,RNLS,ANGPT1,P2RX4,SMAD7,IGF2R,ADGRG1,RCAN1,PLA2G4A,PBX3,VAV3,EDNRA,PTGS2,RCAN2,ADRA1A,MMP9	93	
Cardiovascular Disease	atherosclerotic lesion	atherosclerotic lesion	1.09E-05	 	0.687	 	0.181	APOE,SOCS3,APOB,LEP,ACAT2,PFN1,ZFP36,PLA2G15,ADIPOQ,TNFSF10,TNFAIP3,ARG2,SDC4,TGFBR2,CEL,HMOX1,SHC1,IKBKG,NFKBIA,CCL2,CCL3L3,TIMP1,THBS1,CST3,PLA2G5,LIPG,COL18A1,AGT,CCR1,PTX3,MIF,VCAM1,CD59,SELE,SPP1,EGR1,MMP2,THBD,PLA2G2A,CXCL16,LDLR,CBS/CBSL,ACAT1,CXCL2,ESR1,MMP9	46	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	hormone receptor negative breast cancer	hormone receptor negative breast cancer	1.10E-05	 	 	 	 	CTGF,TGFBR3,PARP2,CDKN2C,IL6,SPI1,POR,MYC,TGFBR2,ETS2,CAV1,TUBA1C,RET,TEK,CSF3R,ETS1,CXCL8,IGFBP6,SPP1,TUBB2A,MMP2,PARP3,JUNB,CCND2,IGFBP3,ESR1,mir-21,FYN,FRZB,FGF2,TNFSF10,JUN,TIMP1,KIT,ERBB2,NCL,PLAT,MYCN,CD276,EGR1,TUBG1,NQO1,CSF1R,PLA2G2A,FOS,NTRK3,MAP3K8,KDR,MMP9	49	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	apoptosis	apoptosis of cancer cells	1.11E-05	 	-0.373	 	0.010	PHLDA1,SOCS3,CXCL12,IL6,SPI1,MYC,RARA,KEAP1,TXN,GSK3B,HIPK2,MCL1,ETS1,MIF,CAPN6,NDRG1,TNFRSF10B,VEGFC,PAWR,BCL2L1,PRKCD,RTN4,IGFBP3,CTSB,ITGA1,NOTCH1,mir-21,VHL,RUNX1,LEP,DDIT3,FGF2,LEPR,GDF15,ABL1,ADIPOQ,TNFSF10,HIF1A,NGF,DIABLO,TRIB1,MTOR,NFKBIA,JUN,KIT,CD24,PRKCE,SEMA3B,BEX2,CD59,TNFRSF14,BTK,ENO1,NR4A2,TF,MCM2,LPAR1,SPRY2,CAT,SPARC,TSC22D1,KDR,MMP9	63	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	BCR-ABL F317L positive Philadelphia-positive chronic myeloid leukemia	BCR-ABL F317L positive Philadelphia-positive chronic myeloid leukemia	1.12E-05	 	 	 	 	SRC,CSK,LYN,ABL1,KIT,RET,AXL,CSF1R,TEK	9	
Protein Synthesis	synthesis	synthesis of protein	1.18E-05	 	0.664	 	-0.052	EIF3C,IL6,EIF6,NCBP2,EIF4EBP3,EIF3B,RARA,TSC2,CAV1,ATF4,ALDH3A1,NANOS1,RRBP1,DKC1,THY1,SERINC1,JUNB,MRPL17,STIP1,PPP1R15A,BTG2,GAPDH,MAP2K3,PLTP,CAPRIN1,NOTCH1,DUS2,SAMD4A,ANG,PHLPP1,EIF3K,ADM,TUFM,EIF4EBP2,ZFP36,DDIT3,FGF2,ADIPOQ,CDK4,TNFSF10,FKBP1A,H2AFZ,EIF4EBP1,DDX3X,MTOR,JUN,DHPS,SARS,RPS24,HELZ,MRPL12,TOB1,RELN,CYP1B1,YBX2,FOS,MRPL51,SWAP70,ZFPM2,S100A9,CBS/CBSL,FAM129A,LYN,IGF2BP2,TP53BP1,MAP3K8,ADRBK1,CD4,HSPA1A/HSPA1B,OGFOD1,PIGQ,HSPA5,LOC102724828/MRPL23,METAP2,MYC,TNIP1,EIF5,GPC1,KLF2,ADRA1B,EIF2AK1,FST,SPP1,EIF4E2,MARS,EPRS,IGFBP3,VHL,SFTPD,LEP,ERN1,MRPL15,BMP2,TPR,ABCF1,SLC7A1,MRPL2,INPPL1,AKIP1,HNRNPK,PDCD4,EDN1,THBS1,RPS6KB2,ARHGEF2,ERBB2,NCL,AGT,PRNP,PATL1,SRC,SMAD7,DNAJC1,MKNK2,HRSP12,WARS,RPS27L,RNMTL1,CPEB1	119	
Developmental Disorder	hypertrophy	hypertrophy of cells	1.18E-05	 	0.475	 	0.178	KCND2,PLIN1,CTGF,BMP4,PFKFB1,SGK1,SNTA1,CACNA1H,LHCGR,IL6,SLC9A1,TGFBR2,GPX3,CTSD,NR4A3,CAMK2D,PLCE1,MYOM1,CYBA,TSC2,NUPR1,CAV1,GSK3B,HEY2,CAST,WNT5B,NOX4,CMKLR1,FST,ATF3,SGCG,HBEGF,IER3,KLF4,LMCD1,STC1,DUSP1,CTSB,MAP2K3,MAPK7,ESR1,mir-21,MAP2K5,FHL1,LEP,LEPR,FGF2,BMP2,GDF15,ABL1,CDK4,ADIPOQ,TNFAIP3,INPPL1,NGF,H2AFZ,SHC1,DUSP5,MTOR,NFKBIA,JUN,EDN1,TIMP1,ADORA1,ADRB2,AGT,SRC,EPAS1,P2RX4,SMAD6,SMAD7,IGF2R,CYP1B1,GRN,EMP1,ADGRG1,CAT,EDNRA,SOX9,PTGS2,MMP9	81	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	astrocytoma	astrocytoma	1.20E-05	 	 	 	 	CA12,HRAS,CDKN2C,ASCC2,ATP2A2,CLIP1,RNF38,PRG4,AJUBA,MCOLN3,LUM,ANK2,MGP,MGAT4B,CAV1,ALPK1,HIPK2,SLCO2B1,ALDOC,WASH3P,TSHZ2,CAPN5,PIK3C2B,SELE,COCH,LHPP,SV2B,PLEC,GRK5,MBD2,TNK2,TFPI2,HSPA8,DOCK1,DVL2,CCND2,MS4A7,ALCAM,RSU1,NOTCH1,mir-21,ZDHHC4,COL3A1,CD163L1,AKAP12,HIST2H2AA3/HIST2H2AA4,MAP7,HIST1H1C,GSTM5,GBP1,CDK4,HYOU1,FKBP1A,IDH1,DTNA,MTOR,TARS2,COL22A1,MYO1D,PCBP2,AHNAK2,RAD21,PTK7,DNAH6,CD209,SLC25A13,MECOM,ANGPT1,IMPDH2,MGMT,SLIT2,NBEA,RELN,EMC1,ID3,HSPA2,COL5A3,LDLR,KIF7,TF,NTRK3,FLNC,BMF,TAGLN,SOX9,TAZ,PTGS2,AOX1,ABCC3,BMP6,KTN1,SPNS1,SERPINI1,PTTG1,MBP,KLF6,TMEM147,CXCL12,HSPA5,COBL,BIN1,GPNMB,MYC,TGFBR2,KCNAB1,DHTKD1,FAR2,CYP4X1,TMEM156,KPNA2,GOT1,GSK3B,RET,RPAP1,TEK,TRIM5,PTX3,PFKFB3,AXIN2,SPP1,EGR3,PTGDS,GSR,PPP2R1A,H3F3A/H3F3B,ABCA8,DBNDD1,BUD31,BAP1,AGAP3,CLCN7,ESR1,RAB11FIP5,PA2G4,FLRT2,DCAF4,BCL2L12,PKM,ABL1,GIMAP6,HIF1A,COL1A2,EPHB6,SOX17,HLA-G,MSRB3,TIMP1,CSPG4,THBS1,FLNA,DKK3,KCNMA1,KIT,ENPP2,ERBB2,CIZ1,ACTN1,CHEK2,ZFP42,SNAPC4,SRC,VCAM1,NLRP3,CXCR4,SLC12A2,LRRK2,RAPGEF5,NUP210L,ANO2,SYBU,CXCL16,COL1A1,LPAR1,VAV3,GAP43,COL11A1,C6,ELK1,KDR,MAP4K4,MMP9	181	
Connective Tissue Development and Function, Tissue Morphology	size	size of connective tissue	1.22E-05	 	1.479	 	1.209	PLIN1,PARP2,LIPE,POMC,IL6,CCND3,MKX,CXCL14,CAV1,CERS6,DPT,SURF1,ARSA,PTGDS,CREB5,CDH2,PKD1,DUSP1,PPP1R15A,HIF1AN,ESR1,APOE,LEP,FGF2,LEPR,GNA11,ADIPOQ,TNFSF10,WDR13,EIF4EBP1,TRIB1,ID1,CES1,GBA,GADD45A,EDN1,PDE3B,SORBS1,PLIN2,ENPP2,AGT,ADRB2,C5AR1,HDC,ST3GAL6,TOB1,BSCL2,CCDC3,PSME3,LDLR,APOC1,LYN,SPARC,ST3GAL4	54	
Cardiovascular System Development and Function, Tissue Morphology	morphology	morphology of blood vessel	1.23E-05	 	 	 	 	ADGRA2,BMP4,RRM2B,TYRO3,CACNA1H,CXCL12,IL6,GPC3,MYC,MFAP2,ITGA3,GPR4,RARA,LUM,MGP,SIAH2,HEY2,KLF2,TEK,PTGIS,ELN,CALCRL,SPP1,MFAP5,C1GALT1C1,SGCB,MMP2,PLOD1,CDH5,PKD1,MAPK7,NOTCH1,VHL,NRP1,COL3A1,B9D1,ADM,LOX,APOE,ADAM17,BMP2,CFC1/CFC1B,HIF1A,MYH11,RAMP2,COL15A1,COL5A1,EFNB2,HMOX1,SHC1,JUN,EDN1,CST3,FLNA,MKL2,ENPP2,PTGER4,HEY1,AGT,MYCN,SRC,EPN1,ANGPT1,CXCR4,G6PD,CDO1,AXL,COL1A1,LDLR,CBS/CBSL,NTRK3,SERPINH1,CNN1,EDNRA,ARHGDIA,GPR180,EFEMP2,ARID4A	78	
Cardiovascular System Development and Function, Tissue Development	morphogenesis	morphogenesis of endothelial tissue	1.26E-05	 	-0.101	bias	-1.143	PIK3C2B,CXCL8,VCAM1,FGF2,MMP2,NGF,ODC1,STC1,EFNB2,COL1A1,ID1,JUN,RHOB,TNMD,MAP2K3,CSNK2B,CXCL2,COL18A1,NOTCH1,PLOD3	20	
Cardiovascular System Development and Function	morphology	morphology of vessel	1.26E-05	 	 	 	 	ADGRA2,BMP4,RRM2B,TYRO3,CACNA1H,CXCL12,IL6,GPC3,MYC,MFAP2,ITGA3,GPR4,RARA,LUM,MGP,SIAH2,HEY2,TMBIM1,KLF2,TEK,PTGIS,ELN,CALCRL,SPP1,MFAP5,C1GALT1C1,MMP2,SGCB,PLOD1,CDH5,PKD1,MAPK7,NOTCH1,VHL,NRP1,COL3A1,B9D1,ADM,APOE,LOX,ADAM17,BMP2,CFC1/CFC1B,HIF1A,MYH11,RAMP2,COL15A1,COL5A1,EFNB2,HMOX1,SHC1,ANGPTL4,JUN,EDN1,THBS1,CST3,FLNA,MKL2,ENPP2,CYP51A1,PTGER4,HEY1,AGT,MYCN,SRC,EPN1,ANGPT1,CXCR4,G6PD,CDO1,AXL,COL1A1,LDLR,CBS/CBSL,NTRK3,SERPINH1,CNN1,VAV3,EDNRA,ARHGDIA,GPR180,EFEMP2,ARID4A,FBN2	84	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	polyarthritis	polyarthritis	1.28E-05	 	1.059	 	0.771	MME,SORL1,ADM,APOE,SCAP,GADD45B,DDIT3,ZFP36,ERN1,NQO2,HSPA1A/HSPA1B,TNFAIP3,SIL1,IL6,CCL3,HLA-G,NR4A3,NFKBIA,CCL3L1,THBS1,S100A8,ERBB2,TXN,LTBR,MAPKAPK2,PTGER4,MCL1,PRNP,PLAT,CCR1,SELE,DNASE2,HNMT,SPP1,CD69,NQO1,PLAUR,F13A1,GSR,FOSB,PLA2G4A,F11R,FOS,NR4A2,S100A9,DUSP1,PTGS2,KDR,ANG,P2RX7	50	
Cardiovascular Disease	peripheral arterial disease	advanced stage peripheral arterial disease	1.28E-05	 	 	 	 	RUNX1,APOE,DNAJB4,CD36,HSPA1A/HSPA1B,HSD17B11,CXCL12,PPP1CB,ADAP2,VWA5A,CD163,GLRX,CAAP1,COL1A2,HSPA4,COL6A1,THBS1,AMPH,SNX10,PLEKHO2,DAB2,STK24,SEMA3B,PTGER4,GULP1,CCR1,UCP2,SPP1,FAHD2A,THY1,VSIG4,CAPG,LMCD1,NGRN,RUFY1,COL1A1,PLA2G4A,NPR3,LYN,CTSB,TPP1,CCL18,NEDD9,MAP4K4,FTH1	45	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function	morphology	morphology of cardiac muscle	1.29E-05	 	 	 	 	ADRBK1,TGFBR3,CACNA1H,ATP2A2,BIN1,POR,IDUA,GAA,LUM,CAV1,HEY2,HADHA,CASQ2,CALCRL,PKP2,PLEC,HBEGF,HMGA1,IER3,BCL2L1,CDH2,ALDH1A2,MAP2K3,MAPK7,NOTCH1,SPTBN1,ADAM17,CDK4,ABL1,FKBP1A,HIF1A,TGM2,SHC1,MKL2,ACADM,HEY1,MYCN,PAK4,VCAM1,EMD,TK2,IGF2R,RCAN1,PLA2G4A,ZFPM2,ITPA,ACADVL,VAV3,RCAN2	49	
Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism	quantity	quantity of Ca2+	1.29E-05	 	-1.122	bias	-3.709	NNAT,SGK1,CACNA1H,HRAS,POMC,IL6,ATP2A2,SLC9A1,GNA15,NMUR2,MCOLN3,CAV1,MGP,CASQ2,MCL1,SELE,PPP1R1B,THY1,GRK5,S1PR3,SPINT2,ADM,FYN,APOE,FGF2,GNA11,ACKR2,HYOU1,FKBP1A,TGM2,LYZ,CCL3L1,CCL2,CCL8,CCL3L3,STIM1,ADORA1,FCGR3A/FCGR3B,S100A1,CCR1,SIGMAR1,C5AR1,CSK,FOS,SWAP70,S100A9,WAS,LYN,MS4A2,S1PR1,FCER1G,PTGS2,ADRA1A,RGS1,ADRBK1,ATP2B1,SPHK2,CXCL12,TRPM8,FCER1A,HSPA5,MYC,CAMK2D,PLCE1,PLA2G5,PRND,CAST,C1QBP,ADRA1B,CXCL8,ELN,SPP1,ITPR2,FIG4,TPSAB1/TPSB2,BCL2L1,NOL3,ORM1,ADRA2A,ESR1,TMOD1,PTGFR,SFTPD,LEP,ZP3,SMPD1,CCL3,NGF,SHC1,CCL13,EDN1,SAA1,MCAM,S100A8,PRNP,ASIP,AGT,SRC,CD59,VCAM1,CXCR4,SLC12A2,BTK,PMP22,VAV3,NUCB2,EDNRA,KDR,P2RX7	109	
Cancer, Organismal Injury and Abnormalities	neoplasia	neoplasia of cells	1.30E-05	 	0.506	 	-0.780	PCLO,VAC14,POR,IDUA,AJUBA,PPRC1,TSC2,DEFB132,WASH3P,ETS1,RBM38,SLX4,C14orf79,ALCAM,mir-21,LTBP2,KIAA1211L,SYNM,RABL6,TRIT1,GPC6,ATN1,MTSS1L,POLR1E,GPAM,PDZD2,AFF3,KIF7,SWAP70,TBC1D8,WBP2,FAM136A,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,TEK,CPNE1,ADAMTS1,UBL4A,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,C19orf54,PSME4,NAGLU,C17orf97,CARS,FEM1A,ZP3,ZNF252P,CLUAP1,GIMAP6,NLRP3,PLAUR,PYGB,FRMD4A,SAA2,CLEC16A,ORAOV1,ANO3,ING1,CXCL2,ASPSCR1,CTGF,GMDS,HOMER3,SGPL1,PRG4,MTUS1,PNKD,MCL1,RND2,PPIL6,TMEM39B,PIK3C2B,DFNA5,NAB1,ATG7,PLEC,HBEGF,HMGA1,CHI3L2,THBD,SH3GL1,MS4A14,MAP3K12,ACAD11,FAM86B1,NCLN,SAC3D1,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CNN2,SORL1,RP9,LEPR,SIN3B,ST6GALNAC4,MEOX2,CADM2,CCL8,ENTPD6,DIP2B,COL22A1,EGFL6,AHNAK2,COL12A1,TRIM28,EGR1,DAAM1,NTM,RELN,SBF1,PTGS2,CHD7,ZFYVE19,COBLL1,CLIP3,LHCGR,TBX15,ZNF91,FAM173A,PLCXD3,PLCE1,ETS2,COMT,DHTKD1,MCTP1,NMNAT2,PGP,EGR3,USP36,IRX6,SLC4A7,ALAD,ATP10A,GALNT13,TPSAB1/TPSB2,SORD,LRRC41,COL6A3,CSN1S1,FRYL,SCRIB,ICK,PTPRF,SSU72,THBS1,ARHGEF35,ASAP3,TPST2,ATP2C1,C9orf3,LRRK2,TANC2,RPS21,CCDC85A,FAF1,EBF1,PLEKHH1,FAM46A,SLIT3,NIPA2,CSTA,HCAR3,SVEP1,MAP6,ANKRD20A4 (includes others),ATP2A2,ODC1,OGFOD3,GNA15,RAB38,ARHGAP39,SPATA18,SLCO2B1,TSHZ2,DPT,MTSS1,ICT1,MFAP5,TNFRSF10B,LAMC3,RPAP3,HAX1,WDR81,TNPO2,MN1,CD86,IGSF10,PTPRA,NME1,FBXO10,NACC2,ZNF205,C9orf24,HCAR1,CUBN,CDK4,CTHRC1,CTDSPL,TECR,ZNF285,SDHAF1,IFI27,DUSP5,POFUT2,CCL2,ARFGAP1,ADORA1,HCAR2,RAD21,MED20,SPRY1,TJP1,MLF2,RGS16,MRPS25,FAM178B,ARHGEF5,LDLR,NTRK3,TP53BP1,PIN1,TMEM8A,ABCA3,HSPA1A/HSPA1B,ACO2,CES2,CD163,MYC,TGFBR2,NNMT,ADGRF5,RHOB,CXCL14,ZNF598,GYPE,NUPR1,STAB1,LILRB5,NEDD4L,FMO4,TEX264,PSMB5,ATF3,FMO2,PKP2,RILPL1,ZNF282,VEGFC,CMSS1,THRA,TRIM35,DCHS1,GZMH,SDCBP,TLN2,MATN2,GIPC1,APCDD1,SORCS2,THAP7,LRRC47,POLR3F,SPIRE2,DENND4B,MECR,NEURL4,SLC2A3,ETV6,RAP1GDS1,CCDC107,HLA-DRB1,AHNAK,TIMP1,MCAM,MEX3B,LOC102724428/SIK1,HES4,VARS,VCAM1,NUSAP1,CTAGE9 (includes others),APBB1IP,SLC12A2,UPP1,PGAP2,ZNF16,N4BP1,PSME3,NFE2L1,SH3PXD2A,PHF19,VAV3,GAPVD1,TRAP1,PCDH7,CDKN2C,GTF2IRD1,NCOA7,SLC4A3,CLCNKA,ABR,SPTLC2,SLC16A2,VEGFD,CSTF2,GUCY1A3,RPA1,MMP2,IER3,RAE1,SERINC2,DOCK1,SRGAP3,PSMB2,MAP3K20,MS4A7,LRP8,AIDA,PDGFD,RALA,EMILIN2,PSMB10,CHCHD6,FOLR2,KAZN,PFKL,KHDC1,VCAN,TMEM94,CA3,MTOR,SRGAP1,ALDH1A3,SOCS2,PRKCE,NAALAD2,TBCD,COL18A1,DNAH6,PTK7,CYP11A1,GSTM1,PCDH9,POLD1,F11R,COL5A3,FAM86C1,CLDN5,ADCK2,ZFP36L2,SYN2,C16orf89,CYP2C8,SERPINI1,ARG2,COBL,D2HGDH,LTBR,MYO10,CSF3R,SPP1,LMO4,MACROD1,PCSK7,LMNA,MYOF,DPP9,GSR,CORO1B,ACOT4,THSD7B,CCL18,AKR1B1,RNPEP,COL7A1,AOC3,ADAMTS7,ERN1,CHPF,BCL2L12,RGS12,RAMP2,FUBP3,SRGN,HIST2H2AC,S100A8,MYO16,PRRT3,RAB11FIP3,TMEM132B,TMEM222,SNAPC4,SPOCD1,LCLAT1,FAM134B,SMAD7,CSF1R,TRMT61A,ITPA,LRP1B,ZNF585A,UBA1,EPB41L2,ATP6V1B2,MMP9,NOMO1 (includes others),IL6,POLRMT,UPK3BL,ATG9A,EIF3B,CCND3,CSE1L,PLXNB2,PTGIS,COMP,KIAA0513,CTSB,EPHX1,GADD45B,COL15A1,DDX3X,SPON1,ABCC9,GTF3C1,MECOM,KIAA1549L,SPATS2L,CDO1,IGF2R,HNRNPH1,LYN,PROCR,SOX9,MXRA5,ARSD,MICALL2,RABEP1,ZFPM1,AP1B1,GPC3,CEP104,OSCP1,CXCL8,NOX4,TJP2,MAN1C1,MAPK8IP2,RIMS4,H6PD,LZTR1,ERCC2,TXNRD1,ZNF296,FAM26F,SLC7A2,BAP1,VHL,SLC11A1,SULF1,LOX,IGFBP4,BMP2,INPPL1,COL6A6,PHLDB2,DHCR7,EDN1,GTPBP2,ERBB2,THBS4,NDUFV1,SRC,SERTAD1,POLR3B,COL11A1,CERCAM,PRUNE2,KCND2,DDX11,BMP4,TYRO3,PCDH17,MST1,GYG2,POMC,EIF6,MIA,EVI5L,ITGA3,PLS3,RARA,KIF21A,MGAT4B,TESK1,FAM127A,CAPN5,EFL1,CMKLR1,TMEM37,CAPN6,ATP8B4,MBD2,MNDA,ROR1,DPH2,CLEC4F,CCZ1/CCZ1B,RTN4,CCT3,ANG,AKAP12,FYN,MAP7,GSTM5,HEATR1,TTLL4,ATAT1,GPC4,RCOR2,TMEM259,CORO2B,THBS3,SF3B3,TIGD5,C20orf96,ENAH,STOM,RPUSD3,CES1,JUN,ZNF334,PDE3B,CD24,NPTXR,FUK,RBBP9,PLXNA1,CEP164,PTPRK,MYOM2,BHLHE22,NBEA,SLIT2,AXL,YIF1B,MRPS18A,GABRE,DCAF13,BRINP2,CILP,ATAD3A,TM4SF1,LRFN4,FARP1,FAT1,MAP1B,GSK3B,RET,PHACTR3,MFSD3,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,GSDMB,PCDHA1,MAPK8IP3,UBXN11,RAP1GAP,PRKCD,N6AMT1,CD14,XPNPEP1,ATF5,SLC4A11,TBCB,CD55,NFKBIA,ANGPTL4,KIAA0040,HSPE1,SMO,CFB,CDCA5,NCL,MAPKAPK2,CHEK2,RHBDD3,EMILIN1,PAK4,EPAS1,PHLDA3,PCOLCE2,LOC401052,CIART,EPHB3,CPZ,C6,KDR,HLA-DOA,ANKRD35,PAPLN,WBSCR22,ASCC1,SERPINA3,CLIP1,FADS3,NSF,EGR2,CTSH,KEAP1,LUM,MGP,CEP170B,KANK3,CAV1,DLG4,ATF4,KAT2A,RNF121,TM6SF1,FAM189B,MASP1,FLOT1,THOP1,IFNAR2,TRAPPC3,SHROOM4,TMEM127,CARD9,EVPL,NRDE2,CTSA,CBLN3,VARS2,FSCN1,BTG2,PRELP,ITGA1,SAMD4A,FGF2,SEMA6A,ZBTB9,CKAP4,HS3ST3A1,TGM2,CS,GADD45A,SORBS1,SWI5,TBC1D10B,ALDH5A1,FCGR3A/FCGR3B,HEY1,FCER2,CNFN,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,GRN,FOS,SNUPN,NR4A2,FLNC,GPBAR1,ATP1A2,MBD3,TAGLN,TAF1C,TMEM106C,SLC22A18,AARS2,MAP3K8,TTYH3,ABCC3,ABCB6,FOXRED1,ATP13A1,AMDHD2,SLC38A10,PTTG1,KLF6,ABCG1,STARD7,HSPA5,GPR4,HDAC11,CHTF18,CAST,LRBA,MAST4,DOK2,GM2A,LAMA2,CLIP2,ANO1,KLF4,CYB561,KCNG1,TRIM39,ORM1,LIMA1,IGFBP3,CAPN2,DNAJB6,MEGF8,KLHDC4,RUNX1,PCMTD2,SF3B5,TPR,ABCF1,CADPS2,NUDT2,GCDH,RPL14,SHC1,SLC19A3,MSRB3,SAA1,RNH1,ENPP2,LRPPRC,TOX2,MCRS1,C4BPB,TUBG1,GATSL3,LARP6,WDR41,PMP22,TACC2,CDC34,ZNF404,PNPLA6,COQ9,NNAT,KCNK15,APOB,DNAJB4,TGFBR3,HRAS,NCSTN,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NPTX2,ANK2,IRS2,EYA2,MATK,NDRG1,PCSK5,RRBP1,TUBB2A,THY1,TNK2,CDH2,TIMP4,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,MAP2K3,ZER1,SFRP1,MAPK7,CYR61,MYEOV,BOD1,SPTBN1,HIST1H1C,ADAM17,NID2,WASF3,TNFSF10,DCLK1,IDH1,COL5A1,ID1,ACSM5,SLC2A6,RHOU,STIM1,TPO,PTPRT,SF3A2,MYH1,STK19,MYCN,VPS18,ANGPT1,TWNK,MGMT,DPAGT1,B4GALT2,RHPN2,S100A9,WAS,SPRY2,CNN1,IGF2BP2,MS4A2,NR5A2,ALS2CL,CBX4,NEDD9,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,LIPE,TPM1,FRMD3,TUBB,MTCH2,CYP26B1,CEL,TNIP1,ITGA11,ASXL2,PDK4,EIF2AK1,IGFBP6,AXIN2,TMIE,TEX2,SNRK,FOXC1,PPP2R1A,C9orf9,ERCC1,PKD1,SLC22A5,PLEKHH3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,TET1,TNFAIP3,GPR34,MYLK,SMPD1,HIF1A,ITGA10,FAM110B,PRKCSH,TNFRSF12A,EVC,COL1A2,SOX17,EPHB6,TMEM119,HMOX1,PCK2,KCNMA1,CSPG4,KIT,NR2F6,STK40,PTGER4,NDUFAF3,PRNP,CXCR4,COPS7A,QSOX1,SLC7A8,NDUFA13,DIP2C,LPAR1,CYTIP,RTN3,DSG2	898	
Cell Cycle	S phase	S phase	1.32E-05	 	1.787	 	0.762	PRPF19,RGCC,CXCL12,HRAS,CDKN2C,POMC,IL6,SPI1,MTCH2,MYC,TGFBR2,MIA,CCND3,SMARCB1,CAV1,GPC1,CDKN1C,H19,SLX4,MAD2L2,LMNA,HBEGF,RPA1,PTOV1,HMGA1,JUNB,KLF4,BCL2L1,CCNG2,ERCC1,CCND2,PRKCD,MAPK7,NOTCH1,mir-21,PMEPA1,SUN1,RUNX1,SULF1,LEP,OSGIN1,FGF2,PAM16,ABL1,RBBP8,CDK4,CCL3,CDKN2B,DDX3X,ID1,HMOX1,SHC1,MTOR,JUN,GADD45A,ERBB2,CIZ1,CHEK2,AGT,FCER2,MYCN,SRC,VPS18,ANGPT1,ID3,CSF1R,TNFRSF14,FOS,NEK11,TF,PEA15,SOX9,TP53BP1,MAP3K8	74	
Cell Death and Survival, Neurological Disease	cell death	cell death of brain cells	1.35E-05	 	-0.587	 	-0.449	KCND2,SERPINI1,ITSN1,ADRBK1,SGK1,MAP1B,KLF6,CXCL12,SH3GLB1,SERPINA3,HSPA5,CTSD,ETS2,TSC2,DLG4,GCLM,GSK3B,CAST,RTN4R,UNG,CXCL8,MIF,ATG7,HBEGF,PAWR,JUNB,BCL2L1,DUSP1,PRKCD,STIP1,GAPDH,MAP2K3,SLC25A10,MAPK7,MAP2K5,APOE,LEP,DDIT3,KCNK3,BMP2,VAPA,ABL1,CDK4,HYOU1,TNFSF10,CADPS2,HIF1A,NGF,GLRX,TGM2,MTOR,NFKBIA,JUN,GBA,C7,RASSF5,ADORA1,ATP13A2,PLAT,PRNP,SRC,UCP2,ATP2C1,EGR1,FAIM,SH3PXD2A,FOS,CAPNS1,TF,NTRK3,CAT,PEA15,PIN1,PTGS2,DNM1L,MAOA	76	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of monocytes	1.37E-05	 	-1.320	 	-1.515	CCR1,APOE,VCAM1,EDN1,DDIT3,CBS/CBSL,ETS2,ITGA1,PTGDS,CXCL2	10	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	glioma cancer	glioma cancer	1.39E-05	 	 	 	 	SERPINI1,PTTG1,MBP,KLF6,CDKN2C,HSPA5,ATP2A2,GPNMB,MYC,TGFBR2,KCNAB1,AJUBA,MGP,CAV1,GOT1,GSK3B,RET,HIPK2,TSHZ2,PTX3,PFKFB3,AXIN2,SPP1,LHPP,EGR3,PTGDS,MBD2,GSR,DOCK1,DVL2,H3F3A/H3F3B,ABCA8,CCND2,BAP1,ALCAM,RSU1,mir-21,COL3A1,AKAP12,HIST2H2AA3/HIST2H2AA4,MAP7,HIST1H1C,PA2G4,GBP1,BCL2L12,PKM,ABL1,CDK4,CDKN2B,IDH1,COL1A2,EPHB6,SOX17,DTNA,MTOR,TIMP1,CSPG4,FLNA,KCNMA1,KIT,ENPP2,ERBB2,RAD21,ACTN1,CHEK2,SRC,VCAM1,MECOM,MGMT,SLC12A2,LRRK2,RAPGEF5,NBEA,RELN,ID3,HSPA2,CXCL16,COL1A1,TF,LPAR1,VAV3,SOX9,GAP43,TAZ,ELK1,KDR,MAP4K4,MMP9	88	
Organismal Injury and Abnormalities	formation	formation of nodule	1.43E-05	 	-0.997	 	-1.587	CCR1,SPP1,LEP,BMP4,CTGF,DDIT3,BMP2,SMAD6,ABL1,SMAD7,TOB1,TGM2,CBS/CBSL,VEGFD,PTGS2,BMP6	16	
Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development	development	development of neurons	1.46E-05	Increased	2.268	bias	-0.625	SLIT3,KCNJ2,MAP6,AXIN1,CACNA1H,CLSTN2,IL6,SLC9A1,EGR2,MCOLN3,KIF1A,TSC2,CAV1,DLG4,EBF2,PLXNB2,HIPK2,TNFRSF21,FLOT1,LRRN3,BTG2,ITGA1,APOE,COL4A5,PLXNA3,EIF4EBP2,FGF2,HEXA,FNTA,LLGL1,CSNK2B,HEY1,UCP2,CUL7,GFRA2,MYO5A,GRN,ARHGEF5,FOS,MYOC,NRXN2,NR4A2,NTRK3,LYN,AFG3L2,PIN1,MT2A,NCDN,MICALL2,DPYSL4,MBP,NNMT,RHOB,MAP2K2,MTMR2,CAST,PDZRN3,MARCO,ATF3,UNC13B,MAPK8IP2,RIMS4,FIG4,THRA,BCL2L1,SDCBP,MATN2,FZD5,SYN1,RUNX1,LOX,SULF1,FAM107A,CDC20,BMP2,FLRT1,CADPS2,ATF6,HNRNPK,SHC1,MKL2,ERBB2,SRC,THBS4,SLC12A2,KIF3B,PMP22,CAPNS1,DNM1L,RER1,BMP4,ITSN1,SGK1,SNTA1,HRAS,POMC,RAPH1,ADGRL1,ITGA3,IRX3,DNAJA3,HEY2,RND2,RIMS3,ATG7,CHN1,THY1,CEP89,TNK2,ROR1,S1PR3,DOCK1,SRGAP3,CDH2,NR1D1,PIP5K1C,STIP1,RTN4,GDPD5,LRP8,CAPRIN1,CYR61,NOTCH1,NRP1,SPTBN1,FYN,RALA,BTG3,EFHD1,SLC1A3,DCLK1,ENAH,EIF4EBP1,UCHL1,ID1,KLF9,EFNB2,MTOR,JUN,CLMN,PRKCE,NPTXR,ADGRB2,IL11RA,PLAT,PRPH,MYCN,PTPRK,EGR1,SLIT2,RELN,TENM4,WAS,ADCY1,DBNL,PTGS2,SYN2,RUFY3,PFN1,FARP1,MAP1B,CXCL12,DYNLT1,WDR5,CRIP1,BRSK1,GSK3B,RET,FBXO45,RTN4R,PTPRE,EGR3,IRX6,FOXC1,--,GDI1,LEP,RNF165,NFIX,EPB41L3,NLGN1,FLRT2,VAPA,ABL1,NGF,PTPRF,PRKCSH,NFKBIA,FLNA,THBS1,MICALL1,NSMF,NR2F6,SULF2,MYO16,ADRB2,PRNP,PAK4,CXCR4,LRRK2,TRIP6,PRMT1,KIF2A,PBX3,EPHB3,EDNRA,GAP43,ELK1,KDR,RTN3,P2RX7	211	
Cellular Development, Cellular Growth and Proliferation	proliferation	proliferation of prostate cancer cell lines	1.48E-05	 	0.478	 	-0.021	KCND2,SOCS3,CBX7,APOB,AKR1C3,CD4,IL6,DNAJB2,HSPA5,RAD23A,MYC,WDR5,ALDH1A1,ETS2,CAV1,SLC7A5,AFAP1,GSK3B,PDK4,HK1,ETS1,HEYL,CXCL8,BIRC7,ATG7,FST,HBEGF,ANO1,TNK2,TFPI2,BCL2L1,PPP2R1A,ZFAND3,CBX1,TRIM39,FSCN1,PRKCD,IGFBP3,ALCAM,ACACA,ITGA7,NOTCH1,mir-21,PMEPA1,INO80B,ADM,AKAP12,SRM,FYN,LEP,PA2G4,FGF2,GDF15,CEBPD,HIF1A,NGF,PDCD4,HMOX1,SHC1,ID1,MTOR,EDN1,SMO,PRKCE,DAB2,ERBB2,RASSF5,HGS,SRC,MIPEP,EGR1,RNF126,HYAL1,DEFB1,AXL,IGF2R,NR4A2,RNF144A,TACC2,VAV3,SOX9,ELK1,BMP6,ALKBH3,MMP9	85	
Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	hepatobiliary system cancer	hepatobiliary system cancer	1.49E-05	 	0.700	 	1.026	PCLO,ASS1,GARS,TLE1,LRRN4CL,SLC39A8,POR,GLB1,PPRC1,SMARCB1,TSC2,VIT,DDIT4,SLX4,DVL2,CDH5,ALCAM,ATG101,KIAA1217,mir-21,FHL1,LTBP2,DDIT3,SLC1A5,KIAA1211L,TMEM79,C1R,TIPARP,LLGL1,ATN1,MTSS1L,RNF157,ID3,PAMR1,GPR183,PDZD2,GPAM,MTHFD1L,AFF3,WDR86,TBC1D8,TCTEX1D2,CA4,HAVCR2,DNAJC15,INTS1,LHFPL2,STRN4,STC2,EEF1E1,NDUFA10,MTMR2,NSMAF,TEK,RASGRP2,ADAMTS1,KANK1,BCL2L1,H3F3A/H3F3B,NAGLU,SUN1,ETV5,CARS,KCNK3,ADH1C,ZNF252P,NHP2,CLUAP1,GIMAP6,THYN1,COL6A1,F8,C16orf59,IGSF8,ELMOD3,FAAP100,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,BTK,ACADVL,ZNF544,SPARC,ING1,MED24,MAP4K4,RPLP0,RER1,ASPSCR1,SNTA1,CA12,ABHD1,RNF38,SGPL1,TMEM268,PRG4,ZNF605,SPAG8,FAM124B,POLR2I,PPIL6,UBXN6,CDKN1C,NAB1,SV2B,HIGD1B,TIMM17B,PLEC,CREB5,FAM193B,IRX5,MS4A14,NCLN,KIAA0368,NOTCH1,EOGT,SORL1,SUSD2,FCGRT,ABI3BP,ZNF234,LEPR,SIN3B,ST6GALNAC4,FKBP1A,COASY,CADM2,ENTPD6,DIP2B,DPCD,TUB,COL22A1,TXNL1,PI16,HGS,AHNAK2,LIMCH1,RPS24,NAP1L4,CD276,FCRLB,STAMBPL1,COL12A1,TRIM28,DAAM1,MED30,ACLY,RELN,DHCR24,CYP4F22,SBF1,KLHL35,CELF2,TMEM63B,PTGS2,AOX1,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,FAM127B,ZNF91,SLC6A16,RSPO3,CNDP2,IKBKG,PLCE1,DHTKD1,COMT,MCTP1,NMNAT2,GOT1,FAM193A,USP36,FAM45A,SLC4A7,ATP10A,ALAD,GALNT13,INHBB,COL6A3,FRYL,SCRIB,TSTD1,RCE1,UVRAG,FPR3,PPIP5K1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,CYGB,SULF2,ASAP3,TMEM104,PARP10,TANC2,LRRK2,DAAM2,ANO2,SYBU,COL1A1,FAF1,PAG1,FAM46A,NCKAP1L,MYPOP,XK,MPV17,SLIT3,SVEP1,SYTL2,CLSTN2,CCDC88C,ASCC2,SLC35C1,ATP2A2,RNASE4,CAAP1,NPL,RCL1,OGFOD3,PPP1R3F,GPRC5C,MYADM,WDR47,SPATA18,MRPL24,PLD3,MTSS1,TIMM44,TMEM98,CARMIL1,LAMC3,OSGIN2,SMOC2,WDR81,SLC7A10,MN1,PPOX,PPP1R15A,P2RX6,CHD1L,SQSTM1,ADIPOR2,IGSF10,PTPRA,TRAPPC5,FKBP2,RNF10,APOE,NME1,TTLL3,FBXO10,SFXN4,ZNF205,CUBN,IGSF1,SCUBE2,HS2ST1,CDK4,CTHRC1,CCL2,ARFGAP1,ALG8,ASPH,ARMCX1,RAD21,CYP51A1,CCR1,BTNL9,S100A1,HELZ,TJP1,STOML1,DGAT2,PTCD1,SAA4,TBC1D13,UBL7,MYOC,ZFPM2,LDLR,NTRK3,ARHGDIA,BMP6,CPXM1,PPIL1,ID4,HAGH,KTN1,MAOA,MEGF9,ABCA3,RTN1,ACO2,TYMP,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GDE1,GYPE,NUPR1,STAB1,LILRB5,KIF25,RPAP1,NBAS,TEX264,FMO2,STARD5,ZNF282,VEGFC,THRA,KCNK12,DCHS1,SMUG1,CDC42BPB,TLN2,ABCA8,CHURC1,LRRC25,VPS37A,ESR1,LRRC47,PMEPA1,MAST2,PTGFR,ERAP2,SLC1A4,CDC20,SCARA5,MECR,ZSWIM3,NEURL4,GSTT1,VPS4A,SLC2A3,IRAK1,AHNAK,TIMP1,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,ATP13A2,VCAM1,NUSAP1,AP1S2,XRN2,GNAI1,ZFPL1,BSCL2,PSME3,ATIC,NFE2L1,FAIM,SH3PXD2A,SLK,PHF19,VAV3,TBC1D7,GAPVD1,SGK1,SH3GLB1,PCDH7,NCOA7,SLC4A3,CLCNKA,ABCC1,RPS2,ALPK1,TMEM9B,NAT10,SERINC1,MMP2,SCNN1D,LONP2,UBQLN4,DOCK1,SRGAP3,YARS,TRO,RPL6,LRP8,PDGFD,ITGA7,ALDH4A1,RALA,PDDC1,NT5C,PFKL,VCAN,SERTAD4,DCLK2,TRIB1,MTOR,WDFY1,ALDH1A3,DAP3,NAALAD2,EPS15L1,AKR1B15,LPP,SARS,COL18A1,NCKIPSD,PLOD3,DNAH6,CYP11A1,SOX7,GSTM1,CCDC130,EPB41L4B,PCDH9,POLD1,RBM6,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,CYP2C8,FZD7,MVD,CYTOR,FNIP2,DYNLT1,COBL,CCNL1,TMED5,MBNL3,LARS,PRND,KPNA2,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,DDX41,PTX3,MGRN1,SPP1,SGCG,ITPR2,LMNA,MYOF,MARS,RPL9,DPP9,GSR,TRAPPC9,R3HDM4,RGN,THSD7B,RNPEP,COL7A1,LEP,FLRT2,C1QTNF1,BCL2L12,UBASH3B,PNMAL1,RGS12,RAMP2,AADAC,FLNA,HSD11B2,ZNHIT2,RNF144B,MYO16,TMEM132B,SNAPC4,SPOCD1,FRMD1,PHOSPHO2,AP3D1,VWCE,CSF1R,TRMT61A,LRP1B,OLFML2B,NDNF,ZNF585A,MMP9,CARM1,CBX7,TOMM40L,RPE,AXIN1,TPRG1,IL6,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,TMEM219,TNFRSF21,SLC2A5,COMP,COCH,TMEM203,GFM1,ERICH1,PTPN3,PTOV1,EPHX1,CD163L1,EVA1B,COL4A5,HSDL1,DDX3X,SPON1,DTNA,ZNF419,ABCC9,GTF3C1,UCP2,MECOM,KIAA1549L,ZNF521,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,SOCS3,ARSD,ANKMY1,FCER1A,ZFPM1,AP1B1,GPC3,CEP104,CTSD,TSEN15,ARHGAP20,ACTG2,KMT5A,ELN,CXCL8,NOX4,STXBP1,MAPK8IP2,CBX6,RIMS4,H6PD,FIG4,AKR1B10,TXNRD1,FCN3,ADRA2A,BAP1,CCDC80,GSDMC,TNS1,SLC11A1,SULF1,PC,COL6A6,ALDH2,DHCR7,SNX16,ERBB2,NDUFV1,PKP1,COL6A2,IPO4,G6PD,AP3B2,POLR3B,COL11A1,PRUNE2,KCND2,RAN,PCDH17,GHITM,NR4A3,EVI5L,LGMN,MKX,RARA,BAALC,KIF21A,MED16,HADHA,ZC3HC1,DKC1,JUNB,MBD2,ROR1,VPS26B,BCAP29,TSR3,FARSA,AAAS,GAMT,EPB42,PDE1B,FAM71E1,RTN4,ME2,ANG,AKAP12,SQLE,HEATR1,PPP1R3C,SLC1A3,HYOU1,GOLGA3,ATAT1,TRPT1,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,GPIHBP1,TIGD5,C20orf96,ENAH,CELF1,RPUSD3,CES1,JUN,PDE3B,CD24,MORN4,PLXNA1,CEP164,NOL6,PTPRK,ARHGAP4,LRSAM1,PAICS,NBEA,SLIT2,AXL,MRPS18A,GABRE,GBP4,SLC48A1,RHBDD2,GTPBP3,BRINP2,GALE,ANXA3,CILP,NENF,TM4SF1,PFN1,FARP1,FAT1,LAMTOR2,CD36,UNC5B,MAP1B,WDR5,CAMK2D,MYOM1,PCYT2,AMPH,GSK3B,RET,HLA-F,EPB41L1,C7orf50,MFSD3,PHACTR3,STX11,HK1,FERMT3,PTPRE,HNMT,TRIOBP,ICA1,PCDHA1,MAPK8IP3,GPAA1,ZNHIT1,FLCN,KIAA0922,RAP1GAP,EXOSC4,RARRES3,CD14,IDO1,TBC1D16,XPNPEP1,ARL2,SPIRE1,SRM,SH3RF3,PA2G4,ATF5,SLC4A11,SMO,CFB,STK24,IFRD1,NCL,ATP5I,CHEK2,RHBDD3,COL5A2,METTL1,VSIG4,CIART,TMEM2,GLMP,GBE1,NUCB2,KDR,DHRS7B,KLHDC8B,ANKRD35,WBSCR22,CLIP1,ADCK1,EIF4EBP3,IQCC,KIF1A,KEAP1,ST6GALNAC2,KANK3,HES6,HIPK2,TM6SF1,STK36,PPP1R1B,TMEM201,ANO6,SMG5,MASP1,NPY5R,IFNAR2,TFPI2,HSPA8,TMEM127,CARD9,EVPL,IFT122,CTSA,VARS2,CCDC178,ITGA1,TULP3,MUSTN1,SAMD4A,CHCHD10,OSGIN1,FGF2,SEMA6A,THOC3,ZBTB9,MMP25,SLC35B2,COL16A1,TGM2,CS,CHDH,SORBS1,OSBPL11,CSNK2B,PIK3R2,MAPKAP1,NINL,TOB1,GLG1,FOS,PLA2G4A,HP,SELM,NRXN2,FLNC,ATP1A2,MBD3,ZCWPW1,SLC22A18,TMEM177,TTYH3,SEMA3C,ABCC3,C11orf68,PTER,ABCB6,MT2A,FOXRED1,ATP13A1,PTTG1,MBP,ABCG1,HSPA5,AP2A2,PADI4,KCNAB1,FAR2,CHTF18,CAST,PDZRN3,KCNJ8,MAST4,CLIP2,LAMA2,ENKD1,CAPG,OSBPL7,CYB561,KCNG1,ALG3,SOBP,IGFBP3,AGAP3,MEGF8,TXNRD2,PPAN,LRRC8B,UBXN1,NMT1,TPR,CADPS2,ATF6,KIFC2,HNRNPK,REXO2,MSRB3,SHC1,NET1,ENPP4,MKL2,ENPP2,LRPPRC,MCRS1,MRPL40,LONP1,AGT,ZNF135,ZNF358,NQO1,TUBGCP2,ADGRG1,PIGB,TACC2,KIF5B,ASTN2,HEPACAM,NOP16,SMG7,IVD,DNM1L,PNPLA6,COQ9,SLC29A4,CADM3,APOB,WDR45,HRAS,MYRIP,DGCR6L,PEX16,CCNB1IP1,ANK2,REEP2,IRS2,TXN,EYA2,ARHGEF4,CALCRL,NDRG1,PCSK5,RRBP1,THY1,TNK2,FAM129B,PLOD1,CTPS1,LDOC1,NR1D1,BSG,PTPRB,CDRT1,ADAMTS18,MAP2K3,ZER1,SFRP1,CYR61,MME,SPTBN1,ADAM17,MSC,GRB14,NID2,UHRF1BP1,TNFSF10,TTC1,DCLK1,RPP40,IDH1,UCHL1,COL5A1,EFNB2,PTS,STARD13,CLMN,PSMD14,KIAA0391,LDLRAP1,RASSF5,LBP,PCBP2,PTPRT,AMFR,PI4KA,MYH1,STK19,VPS18,ADRM1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,WDR12,RHPN2,KRT8,PLEKHG6,TF,PPP1R16B,CNN1,ADCY1,DENND1A,ZSCAN18,S1PR1,CBX4,FBN2,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,DCAKD,TFG,SPHK2,CXCL12,SDC4,DCAF10,FRMD3,CCT8,PLEKHG4,PARVB,TNIP1,SDPR,BRSK1,SLC7A5,PUF60,PDK4,EIF2AK1,PNMA2,AXIN2,TMIE,TEX2,SNRK,PKN1,EPRS,LMCD1,EFS,PPP2R1A,ITGAM,SMOX,GNL3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,SLC7A1,TET1,QPRT,MYLK,ITGA10,SIL1,HIF1A,ACOT7,CDKN2B,FAM110B,PRKCSH,COL1A2,SEPHS2,NFX1,HMOX1,NKD2,AEBP1,PCK2,KCNMA1,C7,POLN,KIT,ARHGEF2,NR2F6,CUL9,ALPL,STK40,HMGCS1,ACTN1,PRNP,CYP27A1,CXCR4,COPS7A,SCIN,ZBTB7C,SLC7A8,CCDC3,WARS,DIP2C,LPAR1,EDNRA,ELK1,RTN3	1035	
Dermatological Diseases and Conditions, Inflammatory Disease, Skeletal and Muscular Disorders	dermatomyositis	dermatomyositis	1.51E-05	 	 	 	 	LOX,TGFBR3,FKBP1A,HIF1A,TAX1BP3,TGFBR2,COL1A2,COL5A1,MTOR,PLS3,COL6A1,DAB2,TBCD,EMILIN1,COL5A2,COL6A2,TUBB2A,ACLY,CYB561,COL1A1,COLEC12,SDCBP,COL6A3,SERPINH1,CELF2,S1PR1,BNIP3L,SPARC,RSU1,mir-21,COL3A1	31	
Cardiovascular System Development and Function, Tissue Morphology	morphology	morphology of artery	1.52E-05	 	 	 	 	ADM,APOE,LOX,BMP4,BMP2,CFC1/CFC1B,RRM2B,CACNA1H,HIF1A,RAMP2,MYC,COL5A1,SHC1,HMOX1,MFAP2,JUN,EDN1,CST3,FLNA,RARA,MGP,MKL2,HEY2,KLF2,TEK,PTGER4,HEY1,AGT,PTGIS,ELN,MYCN,SPP1,MFAP5,MMP2,CDO1,PLOD1,COL1A1,LDLR,CDH5,EDNRA,GPR180,MAPK7,EFEMP2,NOTCH1,NRP1,COL3A1	46	
Hereditary Disorder, Organismal Injury and Abnormalities	fibrillinopathy	fibrillinopathy	1.54E-05	 	 	 	 	COL5A2,LTBP2,MFAP4,MYLK,MYH11,TGFBR2,COL1A2,FLNA,CNN1,TAGLN,COL3A1,ADRB2,ALDOC,FBN2	14	
Cancer, Organismal Injury and Abnormalities	papillary adenocarcinoma	papillary adenocarcinoma	1.56E-05	 	 	 	 	CBX7,TFF3,CMTM4,RGCC,ACP5,METAP2,TGFBR2,ACP6,DHTKD1,RET,TEK,PDK4,ETS1,SPP1,ADAMTS1,MFAP5,THRA,MMP2,TFPI2,CRABP1,ABCA8,RAP1GAP,ALDH1A2,TRO,LRP8,LSM7,MAPK7,SFRP1,NOTCH1,mir-21,HIST2H2AA3/HIST2H2AA4,IGFBP4,ADAMTS7,GSTM5,FLRT2,CUBN,PKM,FKBP1A,HIF1A,COL15A1,EPHB6,EFNB2,DTNA,MTOR,TIMP1,THBS1,MCAM,CMTM8,KIT,CD24,PRKCE,DAB2,TPO,RNF144B,CHEK2,ASIP,MAPKAP1,CXCR4,SLIT2,CSF1R,C2orf88,KRT8,ZFPM2,VAV3,S1PR1,LPAR5,TAF1C,SEMA3C,ABCC3,BMP6,KDR,MMP9,FCGBP	73	
Cardiovascular System Development and Function, Tissue Morphology	abnormal morphology	abnormal morphology of aorta	1.58E-05	 	 	 	 	PTGIS,ELN,APOE,LOX,SPP1,MFAP5,CFC1/CFC1B,MMP2,PLOD1,COL5A1,COL1A1,MFAP2,JUN,EDN1,FLNA,CST3,RARA,MKL2,MGP,EDNRA,EFEMP2,NRP1,COL3A1	23	
Cellular Development, Tissue Development	differentiation	differentiation of bone	1.59E-05	 	-1.138	 	-1.838	BMP4,TGFBR3,IL6,ATP2A2,ATF4,VEGFD,WNT5B,FBL,SFRP4,RRBP1,JUNB,BCAP29,MN1,PDLIM7,TFRC,LRP8,MAP2K3,SFRP1,SQSTM1,CYR61,NOTCH1,NRP1,APOE,FGF2,SLC1A5,ADIPOQ,CEBPD,CTHRC1,TNFSF10,ATP6AP1,VCAN,ID1,EFNB2,MTOR,JUN,CCL2,CCL3L3,CST3,SNX10,LY6E,HEY1,CCR1,CD276,C5AR1,TYROBP,ZNF521,TOB1,ID3,FOS,MYOC,TF,WAS,FCER1G,BMPER,PIN1,PTGS2,BMP6,ID4,FBN2,SOCS3,GPC3,MYC,TGFBR2,ASXL2,ITGA11,GSK3B,PDK4,CXCL8,AXIN2,PTPRE,SPP1,LMNA,FZD9,KLF4,STC1,H3F3A/H3F3B,PRKCD,MDK,SFRP2,LEP,FRZB,BMP2,ABL1,UBASH3B,HIF1A,CCL3,TMEM119,COL6A1,EDN1,HSPE1,SMO,S100A8,ERBB2,HCST,IARS,ALPL,PTGER4,ADRB2,AGT,SRC,SMAD6,SMAD7,CSF1R,BTK,FAF1,RRAS2,CAPNS1,LPAR1,CAT,EDNRA	110	
Cell Death and Survival	apoptosis	apoptosis of phagocytes	1.59E-05	 	0.314	 	0.157	LAMTOR2,HAVCR2,CXCL12,FCER1A,SERPINA3,C1QA,ABCG1,IL6,NR4A3,GSK3B,LTBR,CAST,BIRC3,MCL1,CXCL8,MIF,ATF3,BTG1,TPSAB1/TPSB2,BCL2L1,PRKCD,CD14,MAP2K3,NOTCH1,APOE,ADAM17,SFTPD,LEP,DDIT3,LEPR,TNFSF10,TNFAIP3,CASP4,SMPD1,HIF1A,IRF3,NGF,MTOR,NFKBIA,CCL2,PRKCE,S100A8,HCAR2,PTGER4,PLAT,CXCR4,BTK,PLA2G4A,FOS,LDLR,CAT,FCER1G,MS4A2,CXCL2,P2RX7	55	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	growth	growth of lung tumor	1.67E-05	 	-0.456	 	-0.416	COX17,FHL1,RALA,ATG7,NDRG1,DDIT3,BTG3,PKM,EMX2,HIF1A,CCL3,ODC1,EIF4EBP1,MYC,THBS1,CXCL14,CAV1,ITGA1,ERBB2,PTGS2,MCRS1,DUS2	22	
Cancer, Organismal Injury and Abnormalities	cancer	cancer of cells	1.69E-05	 	0.179	 	-0.622	PCLO,VAC14,POR,IDUA,AJUBA,PPRC1,TSC2,DEFB132,WASH3P,RBM38,SLX4,C14orf79,ALCAM,mir-21,LTBP2,KIAA1211L,SYNM,RABL6,TRIT1,GPC6,ATN1,MTSS1L,POLR1E,GPAM,PDZD2,AFF3,KIF7,SWAP70,TBC1D8,WBP2,FAM136A,STRN4,CARD8,NDUFA10,TUBA1C,NSMAF,TEK,CPNE1,ADAMTS1,UBL4A,KANK1,BCL2L1,CRHBP,H3F3A/H3F3B,C19orf54,PSME4,NAGLU,C17orf97,CARS,FEM1A,ZP3,ZNF252P,CLUAP1,GIMAP6,NLRP3,PLAUR,PYGB,FRMD4A,SAA2,CLEC16A,ORAOV1,ANO3,ING1,CXCL2,ASPSCR1,CTGF,GMDS,HOMER3,SGPL1,PRG4,MTUS1,PNKD,MCL1,RND2,PPIL6,TMEM39B,PIK3C2B,DFNA5,NAB1,ATG7,PLEC,HBEGF,HMGA1,CHI3L2,THBD,MS4A14,MAP3K12,ACAD11,FAM86B1,NCLN,SAC3D1,AKR1C4,NOTCH1,COL3A1,NRP1,SUSD2,CNN2,SORL1,RP9,LEPR,SIN3B,ST6GALNAC4,MEOX2,CADM2,CCL8,ENTPD6,DIP2B,COL22A1,EGFL6,AHNAK2,COL12A1,TRIM28,EGR1,DAAM1,NTM,RELN,SBF1,PTGS2,CHD7,ZFYVE19,COBLL1,CLIP3,LHCGR,TBX15,ZNF91,FAM173A,PLCXD3,PLCE1,ETS2,COMT,DHTKD1,MCTP1,NMNAT2,PGP,EGR3,USP36,IRX6,SLC4A7,ALAD,ATP10A,GALNT13,TPSAB1/TPSB2,SORD,LRRC41,COL6A3,CSN1S1,FRYL,SCRIB,ICK,PTPRF,SSU72,THBS1,ARHGEF35,ASAP3,TPST2,ATP2C1,C9orf3,LRRK2,TANC2,RPS21,CCDC85A,FAF1,EBF1,PLEKHH1,FAM46A,SLIT3,NIPA2,CSTA,HCAR3,SVEP1,MAP6,ANKRD20A4 (includes others),ATP2A2,ODC1,OGFOD3,GNA15,RAB38,ARHGAP39,SPATA18,SLCO2B1,TSHZ2,DPT,MTSS1,ICT1,MFAP5,TNFRSF10B,LAMC3,RPAP3,HAX1,WDR81,TNPO2,MN1,CD86,IGSF10,PTPRA,NME1,FBXO10,NACC2,ZNF205,C9orf24,HCAR1,CUBN,CDK4,CTHRC1,CTDSPL,TECR,ZNF285,SDHAF1,IFI27,DUSP5,POFUT2,CCL2,ARFGAP1,ADORA1,HCAR2,RAD21,MED20,SPRY1,MLF2,RGS16,MRPS25,FAM178B,ARHGEF5,LDLR,NTRK3,TP53BP1,TMEM8A,ABCA3,HSPA1A/HSPA1B,ACO2,CES2,CD163,MYC,TGFBR2,NNMT,ADGRF5,RHOB,ZNF598,CXCL14,GYPE,STAB1,LILRB5,NEDD4L,FMO4,TEX264,ATF3,PSMB5,FMO2,PKP2,RILPL1,VEGFC,CMSS1,DCHS1,GZMH,TLN2,SDCBP,GIPC1,MATN2,APCDD1,SORCS2,THAP7,LRRC47,POLR3F,SPIRE2,DENND4B,MECR,NEURL4,SLC2A3,ETV6,RAP1GDS1,CCDC107,HLA-DRB1,AHNAK,TIMP1,MCAM,MEX3B,LOC102724428/SIK1,HES4,VARS,NUSAP1,VCAM1,CTAGE9 (includes others),APBB1IP,SLC12A2,PGAP2,UPP1,ZNF16,N4BP1,PSME3,NFE2L1,SH3PXD2A,PHF19,VAV3,GAPVD1,TRAP1,PCDH7,CDKN2C,GTF2IRD1,SLC4A3,NCOA7,CLCNKA,ABR,SPTLC2,SLC16A2,CSTF2,VEGFD,GUCY1A3,MMP2,RPA1,IER3,RAE1,SERINC2,DOCK1,SRGAP3,PSMB2,MAP3K20,MS4A7,LRP8,AIDA,PDGFD,EMILIN2,PSMB10,CHCHD6,FOLR2,KAZN,PFKL,KHDC1,VCAN,TMEM94,CA3,MTOR,SRGAP1,SOCS2,PRKCE,NAALAD2,TBCD,COL18A1,DNAH6,PTK7,CYP11A1,GSTM1,PCDH9,POLD1,F11R,COL5A3,FAM86C1,CLDN5,ADCK2,ZFP36L2,SYN2,C16orf89,CYP2C8,SERPINI1,ARG2,COBL,D2HGDH,LTBR,MYO10,CSF3R,SPP1,LMO4,MACROD1,PCSK7,LMNA,MYOF,DPP9,GSR,CORO1B,ACOT4,THSD7B,CCL18,AKR1B1,RNPEP,COL7A1,AOC3,ADAMTS7,ERN1,CHPF,BCL2L12,RGS12,RAMP2,FUBP3,SRGN,HIST2H2AC,S100A8,MYO16,PRRT3,RAB11FIP3,TMEM132B,TMEM222,SNAPC4,SPOCD1,LCLAT1,FAM134B,SMAD7,CSF1R,TRMT61A,ITPA,LRP1B,ZNF585A,UBA1,EPB41L2,ATP6V1B2,MMP9,NOMO1 (includes others),IL6,POLRMT,UPK3BL,ATG9A,EIF3B,CCND3,CSE1L,PLXNB2,PTGIS,COMP,KIAA0513,CTSB,EPHX1,GADD45B,COL15A1,DDX3X,SPON1,ABCC9,GTF3C1,MECOM,KIAA1549L,SPATS2L,CDO1,IGF2R,HNRNPH1,LYN,PROCR,SOX9,MXRA5,ARSD,MICALL2,RABEP1,ZFPM1,AP1B1,GPC3,CEP104,OSCP1,CXCL8,TJP2,MAN1C1,MAPK8IP2,RIMS4,H6PD,LZTR1,ERCC2,TXNRD1,ZNF296,FAM26F,SLC7A2,BAP1,VHL,SLC11A1,SULF1,LOX,IGFBP4,BMP2,INPPL1,COL6A6,PHLDB2,DHCR7,EDN1,GTPBP2,ERBB2,THBS4,NDUFV1,SRC,SERTAD1,POLR3B,COL11A1,CERCAM,PRUNE2,KCND2,DDX11,BMP4,TYRO3,PCDH17,MST1,GYG2,POMC,EIF6,MIA,EVI5L,ITGA3,PLS3,RARA,KIF21A,MGAT4B,TESK1,FAM127A,CAPN5,EFL1,CMKLR1,TMEM37,CAPN6,ATP8B4,MBD2,MNDA,DPH2,CLEC4F,CCZ1/CCZ1B,RTN4,CCT3,AKAP12,FYN,MAP7,GSTM5,HEATR1,TTLL4,ATAT1,GPC4,RCOR2,TMEM259,CORO2B,THBS3,SF3B3,TIGD5,C20orf96,ENAH,STOM,RPUSD3,CES1,JUN,ZNF334,PDE3B,CD24,NPTXR,FUK,RBBP9,PLXNA1,CEP164,PTPRK,MYOM2,BHLHE22,NBEA,SLIT2,AXL,YIF1B,MRPS18A,GABRE,DCAF13,BRINP2,CILP,ATAD3A,TM4SF1,LRFN4,FARP1,FAT1,MAP1B,GSK3B,RET,PHACTR3,MFSD3,KLHDC3,HK1,MT1G,FUCA1,HNMT,TRIOBP,GSDMB,PCDHA1,MAPK8IP3,UBXN11,RAP1GAP,N6AMT1,CD14,XPNPEP1,ATF5,SLC4A11,TBCB,CD55,NFKBIA,ANGPTL4,KIAA0040,HSPE1,CFB,CDCA5,NCL,MAPKAPK2,CHEK2,RHBDD3,EMILIN1,EPAS1,PHLDA3,PCOLCE2,LOC401052,CIART,EPHB3,CPZ,C6,KDR,HLA-DOA,ANKRD35,PAPLN,WBSCR22,ASCC1,SERPINA3,CLIP1,FADS3,NSF,EGR2,CTSH,KEAP1,LUM,MGP,CEP170B,KANK3,CAV1,DLG4,ATF4,KAT2A,RNF121,TM6SF1,FAM189B,MASP1,FLOT1,THOP1,IFNAR2,TRAPPC3,SHROOM4,TMEM127,CARD9,EVPL,NRDE2,CTSA,CBLN3,VARS2,FSCN1,BTG2,PRELP,ITGA1,SAMD4A,FGF2,SEMA6A,ZBTB9,CKAP4,HS3ST3A1,TGM2,CS,GADD45A,SORBS1,SWI5,TBC1D10B,ALDH5A1,FCGR3A/FCGR3B,HEY1,FCER2,CNFN,CUL7,SLCO2A1,TRIB3,GPM6B,AGL,HSPA2,GRN,FOS,SNUPN,NR4A2,FLNC,ATP1A2,MBD3,TAGLN,TAF1C,TMEM106C,SLC22A18,AARS2,MAP3K8,TTYH3,ABCC3,ABCB6,FOXRED1,ATP13A1,AMDHD2,SLC38A10,PTTG1,ABCG1,STARD7,HSPA5,GPR4,HDAC11,CHTF18,CAST,LRBA,MAST4,DOK2,GM2A,LAMA2,CLIP2,ANO1,KLF4,CYB561,KCNG1,TRIM39,ORM1,LIMA1,IGFBP3,CAPN2,DNAJB6,MEGF8,KLHDC4,RUNX1,PCMTD2,SF3B5,TPR,ABCF1,CADPS2,NUDT2,GCDH,RPL14,SHC1,SLC19A3,MSRB3,SAA1,RNH1,ENPP2,LRPPRC,TOX2,MCRS1,C4BPB,TUBG1,GATSL3,LARP6,WDR41,PMP22,TACC2,CDC34,ZNF404,PNPLA6,COQ9,NNAT,KCNK15,APOB,TGFBR3,HRAS,NCSTN,RAPH1,GRWD1,SATB2,MFAP2,PEX16,NPTX2,ANK2,IRS2,EYA2,NDRG1,PCSK5,RRBP1,TUBB2A,THY1,TNK2,CDH2,TIMP4,BSG,PTPA,STIP1,NPRL3,CDRT1,ADAMTS18,MAP2K3,ZER1,SFRP1,MAPK7,CYR61,MYEOV,BOD1,SPTBN1,HIST1H1C,NID2,WASF3,TNFSF10,DCLK1,IDH1,COL5A1,ID1,ACSM5,SLC2A6,RHOU,STIM1,TPO,PTPRT,SF3A2,MYH1,STK19,MYCN,VPS18,ANGPT1,TWNK,MGMT,DPAGT1,B4GALT2,RHPN2,S100A9,WAS,SPRY2,CNN1,IGF2BP2,MS4A2,NR5A2,ALS2CL,CBX4,NEDD9,FBN2,PHLDA1,SPHK2,CXCL12,XPO5,LIPE,TPM1,FRMD3,TUBB,MTCH2,CYP26B1,CEL,TNIP1,ITGA11,ASXL2,PDK4,EIF2AK1,IGFBP6,AXIN2,TMIE,TEX2,SNRK,FOXC1,PPP2R1A,C9orf9,ERCC1,PKD1,SLC22A5,PLEKHH3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,PPP1CB,TNFAIP3,TET1,GPR34,MYLK,SMPD1,ITGA10,FAM110B,PRKCSH,TNFRSF12A,EVC,COL1A2,SOX17,EPHB6,HMOX1,TMEM119,PCK2,KCNMA1,CSPG4,KIT,NR2F6,STK40,PTGER4,CXCR4,COPS7A,QSOX1,SLC7A8,NDUFA13,DIP2C,LPAR1,CYTIP,RTN3,DSG2	874	
Cardiovascular System Development and Function, Cellular Movement	cell movement	cell movement of microvascular endothelial cells	1.71E-05	Decreased	-2.050	 	-2.497	ADM,CXCL8,TJP1,FGF2,CXCL12,SLIT2,FOXC1,TGFBR2,NEU1,EFNB2,PLA2G4A,CDH5,ORM1,TIMP1,THBS1,VAV3,ARHGEF6,COL18A1	18	
Embryonic Development, Organ Development, Organismal Development, Tissue Development, Visual System Development and Function	development	development of cornea	1.76E-05	 	-0.086	 	-0.970	CXCL8,VCAM1,PSMB10,FGF2,VEGFC,THBD,TNFRSF12A,ANGPTL4,ALDH1A1,CDH5,CCL2,CSPG4,THBS1,ALDH1A3,CXCL14,LUM,VEGFD,LYVE1,COL18A1	19	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	HER2 negative hormone receptor negative breast cancer	HER2 negative hormone receptor negative breast cancer	1.78E-05	 	 	 	 	FYN,CTGF,FRZB,FGF2,TGFBR3,PARP2,TNFSF10,CDKN2C,IL6,SPI1,MYC,TGFBR2,JUN,TIMP1,ETS2,CAV1,KIT,TUBA1C,ERBB2,RET,NCL,TEK,PLAT,ETS1,CSF3R,IGFBP6,MYCN,CXCL8,CD276,SPP1,EGR1,TUBG1,TUBB2A,NQO1,MMP2,JUNB,PARP3,CSF1R,PLA2G2A,FOS,CCND2,NTRK3,IGFBP3,MAP3K8,KDR,ESR1,mir-21,MMP9	48	
Cellular Development	differentiation	differentiation of leukemia cell lines	1.78E-05	 	-0.296	 	-0.805	RUNX1,SOCS3,AKR1C3,NID2,LEPR,ABL1,CEBPD,CTSG,HRAS,CTDSPL,AUP1,IL6,HIF1A,SPI1,ETV6,MYC,HMOX1,SHC1,KAT2B,GNA15,TIMP1,ETS2,CSF2RA,RARA,KIT,ATF4,STIM1,C1QBP,TMBIM1,MCL1,SRC,MIF,CTSK,STK39,EGR1,SMAD7,SCIN,THBD,RELN,KLF4,PRMT1,ENO1,BCL2L1,BTG2,LYN,PTGS2,ESR1,NOTCH1	48	

Tox Functions for My Projects->David Bulger->P1
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Cardiac Infarction	myocardial infarction	myocardial infarction	1.22E-06	 	-0.435	 	0.087	HCAR3,KCNJ2,CD36,CXCL12,IL6,CD163,NNMT,PADI4,CYBA,PLA2G5,TSC2,TUBA1C,GCLM,GSK3B,ADRA1B,ACTA1,PTX3,CSF3R,MYDGF,GUCY1A3,TUBB2A,THRA,THBD,NOL3,ITGAM,ADRA2A,VKORC1,NCF2,CD14,LRP8,ESR1,COL3A1,APOE,KCNK3,FGF2,GDF15,ADIPOQ,QPRT,HIF1A,NGF,TGM2,HMOX1,CD55,EDN1,CCL3L3,PRKCE,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ADRB2,PLAT,AGT,GSTM1,RNLS,ATP2C1,CXCR4,TUBG1,F13A1,CSF1R,GABRE,LDLR,FCER1G,PTGS2,C6,MMP9,ADRA1A,CYP2C8	68	
Renal Damage	nephrotoxicity	nephrotoxicity	3.23E-06	 	 	 	 	BMP4,NGF,GSS,ODC1,COL5A1,LYZ,CCL3L3,TIMP1,PSMA3,ADORA1,CRYM,GJB2,HADHA,GSTM1,SPP1,CXCR4,NQO1,G6PD,ST6GALNAC3,JUNB,TXNRD1,GSR,ERCC1,BTG2,SLC22A5,ACAT1,IGFBP3,RGN,SLC27A1,PECR,HAGH,COL3A1	32	
Renal Necrosis/Cell Death	cell death	cell death of kidney cells	3.53E-06	 	-1.590	 	-2.664	GFPT1,CTGF,MST1,HRAS,SGPL1,MCOLN3,ABCC1,ZHX2,HIPK2,MCL1,PTGIS,ATG7,COMP,TNFRSF10B,IER3,HAX1,PPP1R15A,TFRC,GAPDH,SFRP1,mir-21,FYN,APOE,GSTM5,DDIT3,FGF2,HYOU1,TNFSF10,CASP4,DAP3,RASSF5,ADORA1,NDUFAB1,ATN1,RAD21,EMP3,TRIB3,SRXN1,PLA2G4A,FOS,MYOC,NTRK3,PEA15,LYN,BNIP3L,MAP3K8,PTGS2,RFXANK,ADRBK1,CA4,UNC5B,HSPA1A/HSPA1B,HSPA5,MYC,IKBKG,NEO1,GSK3B,BIRC3,HK1,SPP1,ATF3,TJP2,UNC13B,GNG2,PAWR,PTGDS,BCL2L1,NOL3,PKD1,TRIM39,DUSP1,PRKCD,IGFBP3,ALDH3B1,ESR1,RBP4,ERN1,ATF6,HIF1A,IRF3,NFKBIA,EDN1,STUB1,ERBB2,ATP13A2,AGT,PRNP,NLRP3,AQP11,SMAD7,PRMT1,SLK,EMP1,PMP22,CAT,TNFRSF19,SLC47A1,P2RX7	98	
Renal Damage, Renal Tubule Injury	proximal tubular toxicity	proximal tubular toxicity	3.58E-06	 	 	 	 	BMP4,NGF,GSS,ODC1,COL5A1,LYZ,CCL3L3,TIMP1,PSMA3,ADORA1,CRYM,GJB2,HADHA,GSTM1,SPP1,CXCR4,NQO1,G6PD,ST6GALNAC3,JUNB,TXNRD1,GSR,BTG2,SLC22A5,ACAT1,IGFBP3,RGN,SLC27A1,PECR,HAGH,COL3A1	31	
Liver Hyperplasia/Hyperproliferation	liver tumor	liver tumor	1.04E-05	 	-0.206	 	0.241	PCLO,ASS1,GARS,TLE1,LRRN4CL,SLC39A8,POR,GLB1,PPRC1,TSC2,VIT,RBM38,DDIT4,SLX4,DVL2,CDH5,ALCAM,ATG101,KIAA1217,mir-21,FHL1,LTBP2,DDIT3,SLC1A5,KIAA1211L,TMEM79,C1R,TIPARP,LLGL1,ATN1,MTSS1L,RNF157,ID3,PAMR1,GPR183,PDZD2,GPAM,MTHFD1L,AFF3,WDR86,TBC1D8,TCTEX1D2,CA4,HAVCR2,DNAJC15,INTS1,LHFPL2,STRN4,STC2,EEF1E1,NDUFA10,MTMR2,NSMAF,TEK,RASGRP2,ADAMTS1,KANK1,BCL2L1,H3F3A/H3F3B,NAGLU,SUN1,ETV5,CARS,KCNK3,ZNF252P,NHP2,CLUAP1,GIMAP6,THYN1,COL6A1,F8,C16orf59,IGSF8,ELMOD3,FAAP100,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,BTK,ACADVL,ZNF544,SPARC,ING1,MED24,MAP4K4,RER1,ASPSCR1,SNTA1,CA12,ABHD1,RNF38,SGPL1,TMEM268,PRG4,ZNF605,SPAG8,FAM124B,POLR2I,PPIL6,UBXN6,CDKN1C,NAB1,SV2B,HIGD1B,TIMM17B,PLEC,CREB5,FAM193B,IRX5,MS4A14,NCLN,KIAA0368,NOTCH1,EOGT,SORL1,SUSD2,FCGRT,ABI3BP,LEPR,ZNF234,NQO2,SIN3B,ST6GALNAC4,FKBP1A,COASY,CADM2,ENTPD6,DIP2B,DPCD,TUB,COL22A1,TXNL1,PI16,HGS,AHNAK2,LIMCH1,RPS24,NAP1L4,CD276,FCRLB,STAMBPL1,COL12A1,TRIM28,DAAM1,MED30,RELN,ACLY,DHCR24,CYP4F22,SBF1,KLHL35,CELF2,TMEM63B,PTGS2,AOX1,WDR25,ARID4A,CHD7,ZFYVE19,COBLL1,FAM127B,ZNF91,SLC6A16,RSPO3,CNDP2,IKBKG,PLCE1,DHTKD1,COMT,MCTP1,NMNAT2,GOT1,FAM193A,USP36,FAM45A,SLC4A7,ATP10A,ALAD,PAWR,GALNT13,INHBB,COL6A3,FRYL,SCRIB,TSTD1,RCE1,UVRAG,FPR3,PPIP5K1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,CYGB,SULF2,ASAP3,TMEM104,PARP10,TANC2,LRRK2,DAAM2,ANO2,SYBU,COL1A1,FAF1,PAG1,FAM46A,NCKAP1L,MYPOP,XK,MPV17,SLIT3,SVEP1,SYTL2,CLSTN2,CCDC88C,ASCC2,SLC35C1,ATP2A2,ODC1,RNASE4,CAAP1,NPL,RCL1,OGFOD3,PPP1R3F,GPRC5C,MYADM,WDR47,SPATA18,MRPL24,PLD3,MTSS1,TIMM44,TMEM98,CARMIL1,LAMC3,OSGIN2,SMOC2,WDR81,SLC7A10,MN1,PPOX,PPP1R15A,P2RX6,CHD1L,SQSTM1,ADIPOR2,IGSF10,PTPRA,TRAPPC5,FKBP2,RNF10,APOE,NME1,TTLL3,FBXO10,SFXN4,ZNF205,CUBN,IGSF1,SCUBE2,HS2ST1,CDK4,CTHRC1,CCL2,ARFGAP1,ALG8,ASPH,ARMCX1,RAD21,CYP51A1,CCR1,BTNL9,S100A1,HELZ,TJP1,STOML1,DGAT2,PTCD1,SAA4,TBC1D13,UBL7,MYOC,ZFPM2,LDLR,NTRK3,ARHGDIA,BMP6,CPXM1,PPIL1,ID4,HAGH,KTN1,MEGF9,ABCA3,RTN1,ACO2,TYMP,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GDE1,GYPE,NUPR1,STAB1,LILRB5,KIF25,RPAP1,NBAS,TEX264,FMO2,STARD5,ZNF282,VEGFC,THRA,KCNK12,DCHS1,SMUG1,CDC42BPB,TLN2,ABCA8,CHURC1,LRRC25,VPS37A,ESR1,LRRC47,PMEPA1,MAST2,PTGFR,ERAP2,SLC1A4,CDC20,SRPX,SCARA5,MECR,ZSWIM3,NEURL4,GSTT1,VPS4A,SLC2A3,IRAK1,AHNAK,TIMP1,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,ATP13A2,VCAM1,NUSAP1,AP1S2,XRN2,GNAI1,ZFPL1,BSCL2,PSME3,ATIC,NFE2L1,FAIM,SH3PXD2A,SLK,XYLT2,PHF19,VAV3,TBC1D7,GAPVD1,SGK1,SH3GLB1,PCDH7,NCOA7,SLC4A3,CLCNKA,ABCC1,RPS2,ALPK1,TMEM9B,NAT10,SERINC1,MMP2,SCNN1D,LONP2,UBQLN4,DOCK1,SRGAP3,YARS,TRO,RPL6,LRP8,PDGFD,ITGA7,ALDH4A1,RALA,PDDC1,NT5C,PFKL,VCAN,SERTAD4,DCLK2,TRIB1,MTOR,WDFY1,ALDH1A3,DAP3,NAALAD2,EPS15L1,AKR1B15,LPP,SARS,COL18A1,NCKIPSD,PLOD3,DNAH6,CYP11A1,SOX7,GSTM1,CCDC130,EPB41L4B,PCDH9,POLD1,RBM6,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,CYP2C8,FZD7,MVD,CYTOR,FNIP2,DYNLT1,COBL,CCNL1,TMED5,MBNL3,LARS,PRND,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,DDX41,PTX3,MGRN1,SPP1,SGCG,ITPR2,LMNA,MYOF,MARS,DPP9,GSR,TRAPPC9,R3HDM4,RGN,THSD7B,RNPEP,COL7A1,LEP,FLRT2,C1QTNF1,BCL2L12,UBASH3B,PNMAL1,RGS12,RAMP2,AADAC,FLNA,HSD11B2,ZNHIT2,RNF144B,MYO16,TMEM132B,SNAPC4,SPOCD1,FRMD1,PHOSPHO2,AP3D1,VWCE,CSF1R,TRMT61A,LRP1B,OLFML2B,NDNF,ZNF585A,MMP9,CARM1,CBX7,TOMM40L,RPE,AXIN1,TPRG1,IL6,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,TMEM219,TNFRSF21,SLC2A5,COMP,COCH,TMEM203,GFM1,ERICH1,PTPN3,PTOV1,EPHX1,CD163L1,EVA1B,COL4A5,HSDL1,DDX3X,SPON1,DTNA,ABCC9,GTF3C1,UCP2,MECOM,KIAA1549L,ZNF521,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,SOCS3,ARSD,ANKMY1,FCER1A,ZFPM1,AP1B1,GPC3,CEP104,CTSD,TSEN15,ARHGAP20,ACTG2,KMT5A,ELN,CXCL8,NOX4,STXBP1,MAPK8IP2,CBX6,RIMS4,H6PD,FIG4,AKR1B10,TXNRD1,FCN3,ADRA2A,CCDC80,GSDMC,TNS1,SLC11A1,VHL,SULF1,PC,COL6A6,ALDH2,DHCR7,SNX16,ERBB2,NDUFV1,PKP1,COL6A2,IPO4,G6PD,AP3B2,POLR3B,COL11A1,PRUNE2,KCND2,RAN,PCDH17,MST1,GHITM,NR4A3,EVI5L,LGMN,MKX,RARA,BAALC,KIF21A,MED16,HADHA,ZC3HC1,DKC1,MBD2,ROR1,VPS26B,BCAP29,TSR3,FARSA,AAAS,GAMT,EPB42,PDE1B,FAM71E1,RTN4,ME2,ANG,AKAP12,SQLE,HEATR1,PPP1R3C,SLC1A3,HYOU1,GOLGA3,ATAT1,TRPT1,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,GPIHBP1,TIGD5,C20orf96,ENAH,CELF1,RPUSD3,CES1,JUN,PDE3B,CD24,MORN4,PLXNA1,CEP164,NOL6,PTPRK,ARHGAP4,LRSAM1,PAICS,NBEA,SLIT2,AXL,MRPS18A,GABRE,GBP4,SLC48A1,RHBDD2,GTPBP3,BRINP2,GALE,ANXA3,CILP,NENF,PFN1,FARP1,FAT1,LAMTOR2,CD36,UNC5B,MAP1B,WDR5,CAMK2D,MYOM1,PCYT2,AMPH,GSK3B,RET,HLA-F,EPB41L1,C7orf50,MFSD3,PHACTR3,STX11,HK1,FERMT3,PTPRE,HNMT,TRIOBP,ICA1,PCDHA1,MAPK8IP3,GPAA1,ZNHIT1,FLCN,KIAA0922,RAP1GAP,EXOSC4,RARRES3,IDO1,TBC1D16,XPNPEP1,ARL2,SPIRE1,SRM,SH3RF3,PA2G4,ATF5,SLC4A11,SMO,CFB,STK24,IFRD1,NCL,ATP5I,CHEK2,RHBDD3,COL5A2,METTL1,VSIG4,CIART,TMEM2,GLMP,GBE1,NUCB2,KDR,DHRS7B,KLHDC8B,ANKRD35,WBSCR22,CLIP1,ADCK1,EIF4EBP3,IQCC,KIF1A,KEAP1,ST6GALNAC2,KANK3,HES6,HIPK2,TM6SF1,STK36,PPP1R1B,TMEM201,ANO6,SMG5,MASP1,NPY5R,IFNAR2,TFPI2,HSPA8,TMEM127,CARD9,EVPL,IFT122,CTSA,VARS2,CCDC178,ITGA1,TULP3,MUSTN1,SAMD4A,CHCHD10,OSGIN1,FGF2,SEMA6A,THOC3,ZBTB9,MMP25,SLC35B2,COL16A1,TGM2,CHDH,GADD45A,SORBS1,OSBPL11,CSNK2B,PIK3R2,MAPKAP1,NINL,TOB1,GLG1,FOS,PLA2G4A,HP,SELM,NRXN2,FLNC,ATP1A2,MBD3,ZCWPW1,SLC22A18,TMEM177,TTYH3,SEMA3C,ABCC3,C11orf68,PTER,ABCB6,MT2A,FOXRED1,ATP13A1,PTTG1,MBP,ABCG1,HSPA5,AP2A2,PADI4,GPR4,KCNAB1,FAR2,CHTF18,CAST,PDZRN3,KCNJ8,MAST4,LAMA2,ENKD1,CAPG,OSBPL7,CYB561,KCNG1,ALG3,SOBP,IGFBP3,AGAP3,MEGF8,TXNRD2,PPAN,LRRC8B,UBXN1,NMT1,TPR,CADPS2,ATF6,KIFC2,HNRNPK,REXO2,MSRB3,SHC1,NET1,ENPP4,MKL2,ENPP2,LRPPRC,MCRS1,MRPL40,LONP1,AGT,ZNF135,ZNF358,NQO1,TUBGCP2,ADGRG1,PIGB,TACC2,KIF5B,ASTN2,HEPACAM,NOP16,SMG7,IVD,DNM1L,PNPLA6,COQ9,SLC29A4,CADM3,APOB,WDR45,HRAS,MYRIP,DGCR6L,PEG10,PEX16,CCNB1IP1,ANK2,REEP2,IRS2,TXN,EYA2,ARHGEF4,CALCRL,NDRG1,PCSK5,RRBP1,THY1,TNK2,FAM129B,PLOD1,CTPS1,LDOC1,NR1D1,BSG,PTPRB,CDRT1,ADAMTS18,GLUL,MAP2K3,ZER1,SFRP1,CYR61,MME,SPTBN1,ADAM17,MSC,GRB14,NID2,UHRF1BP1,TNFSF10,TTC1,DCLK1,RPP40,IDH1,UCHL1,COL5A1,EFNB2,PTS,STARD13,CLMN,PSMD14,KIAA0391,LDLRAP1,RASSF5,LBP,PCBP2,PTPRT,AMFR,PI4KA,MYH1,STK19,VPS18,ADRM1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,WDR12,CYP1B1,RHPN2,KRT8,PLEKHG6,TF,PPP1R16B,CNN1,ADCY1,DENND1A,ZSCAN18,S1PR1,CBX4,FBN2,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,DCAKD,TFG,SPHK2,CXCL12,SDC4,DCAF10,FRMD3,CCT8,PLEKHG4,PARVB,TNIP1,SDPR,BRSK1,SLC7A5,PUF60,PDK4,EIF2AK1,PNMA2,AXIN2,TMIE,TEX2,SNRK,PKN1,EPRS,LMCD1,EFS,PPP2R1A,ITGAM,SMOX,GNL3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,SLC7A1,TET1,QPRT,MYLK,ITGA10,SIL1,HIF1A,ACOT7,CDKN2B,FAM110B,PRKCSH,COL1A2,SEPHS2,NFX1,HMOX1,NKD2,AEBP1,PCK2,KCNMA1,C7,POLN,KIT,ARHGEF2,NR2F6,CUL9,ALPL,STK40,HMGCS1,ACTN1,PRNP,CYP27A1,CXCR4,COPS7A,SCIN,ZBTB7C,SLC7A8,CCDC3,WARS,DIP2C,LPAR1,EDNRA,ELK1,RTN3	1035	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart	1.06E-05	 	0.088	 	0.431	KCND2,CTGF,PFN1,BMP4,PFKFB1,CD36,CACNA1H,CXCL12,HRAS,TPM1,IL6,SLC9A1,ATP2A2,GPX3,NR4A3,CTSD,CAMK2D,PLCE1,MYOM1,GAA,PNKD,CAV1,TXN,GSK3B,ACTG2,HEY2,CASQ2,ELN,NOX4,MIF,CMKLR1,ATF3,NAB1,GUCY1A3,HBEGF,GRK5,HMGA1,IER3,KLF4,LMCD1,ADRA2A,DUSP1,PRKCD,CTSB,MAP2K3,MAPK7,mir-21,MAP2K5,RBP4,ADM,APOE,ADAM17,LEP,LEPR,FGF2,GNA11,GDF15,ADIPOQ,FKBP1A,TNFAIP3,HIF1A,H2AFZ,EIF4EBP1,HMOX1,SHC1,DUSP5,MTOR,NFKBIA,JUN,EDN1,RGS5,TIMP1,PRKCE,ADORA1,ADRB2,PLAT,AGT,EPAS1,RNLS,ANGPT1,P2RX4,SMAD7,IGF2R,ADGRG1,RCAN1,PLA2G4A,PBX3,VAV3,EDNRA,PTGS2,RCAN2,ADRA1A,MMP9	93	
Liver Hyperplasia/Hyperproliferation	cancer	liver cancer	3.66E-05	 	0.602	 	0.942	PCLO,ASS1,GARS,TLE1,LRRN4CL,SLC39A8,POR,GLB1,PPRC1,TSC2,VIT,DDIT4,SLX4,DVL2,CDH5,ALCAM,ATG101,KIAA1217,mir-21,FHL1,LTBP2,DDIT3,SLC1A5,KIAA1211L,TMEM79,C1R,TIPARP,LLGL1,ATN1,MTSS1L,RNF157,ID3,PAMR1,GPR183,PDZD2,GPAM,MTHFD1L,AFF3,WDR86,TBC1D8,TCTEX1D2,CA4,HAVCR2,DNAJC15,INTS1,LHFPL2,STRN4,STC2,EEF1E1,NDUFA10,MTMR2,NSMAF,TEK,RASGRP2,ADAMTS1,KANK1,BCL2L1,H3F3A/H3F3B,NAGLU,SUN1,ETV5,CARS,KCNK3,ZNF252P,NHP2,CLUAP1,GIMAP6,THYN1,COL6A1,F8,C16orf59,IGSF8,ELMOD3,FAAP100,PLAUR,SNX27,FRMD4A,SAA2,CLEC16A,BTK,ACADVL,ZNF544,SPARC,ING1,MED24,MAP4K4,RER1,ASPSCR1,SNTA1,CA12,ABHD1,RNF38,SGPL1,TMEM268,PRG4,ZNF605,SPAG8,FAM124B,POLR2I,PPIL6,UBXN6,CDKN1C,NAB1,SV2B,HIGD1B,TIMM17B,PLEC,CREB5,FAM193B,IRX5,MS4A14,NCLN,KIAA0368,NOTCH1,EOGT,SORL1,SUSD2,FCGRT,ABI3BP,ZNF234,LEPR,SIN3B,ST6GALNAC4,FKBP1A,COASY,CADM2,ENTPD6,DIP2B,DPCD,TUB,COL22A1,TXNL1,PI16,HGS,AHNAK2,LIMCH1,RPS24,NAP1L4,CD276,FCRLB,STAMBPL1,COL12A1,TRIM28,DAAM1,MED30,ACLY,RELN,DHCR24,CYP4F22,SBF1,KLHL35,CELF2,TMEM63B,AOX1,PTGS2,WDR25,CHD7,ARID4A,ZFYVE19,COBLL1,FAM127B,ZNF91,SLC6A16,RSPO3,CNDP2,IKBKG,PLCE1,DHTKD1,COMT,MCTP1,NMNAT2,GOT1,FAM193A,USP36,FAM45A,SLC4A7,ATP10A,ALAD,GALNT13,INHBB,COL6A3,FRYL,SCRIB,TSTD1,RCE1,UVRAG,FPR3,PPIP5K1,PTPRF,ARHGAP17,THBS1,MARCH8,USP47,CYGB,SULF2,ASAP3,TMEM104,PARP10,TANC2,LRRK2,DAAM2,ANO2,SYBU,COL1A1,FAF1,PAG1,FAM46A,NCKAP1L,MYPOP,XK,MPV17,SLIT3,SVEP1,SYTL2,CLSTN2,CCDC88C,ASCC2,SLC35C1,ATP2A2,RNASE4,CAAP1,NPL,RCL1,OGFOD3,PPP1R3F,GPRC5C,MYADM,WDR47,SPATA18,MRPL24,PLD3,MTSS1,TIMM44,TMEM98,CARMIL1,LAMC3,OSGIN2,SMOC2,WDR81,SLC7A10,MN1,PPOX,PPP1R15A,P2RX6,CHD1L,SQSTM1,ADIPOR2,IGSF10,PTPRA,TRAPPC5,FKBP2,RNF10,APOE,NME1,TTLL3,FBXO10,SFXN4,ZNF205,CUBN,IGSF1,SCUBE2,HS2ST1,CDK4,CTHRC1,CCL2,ARFGAP1,ALG8,ASPH,ARMCX1,RAD21,CYP51A1,CCR1,BTNL9,S100A1,HELZ,TJP1,STOML1,DGAT2,PTCD1,SAA4,TBC1D13,UBL7,MYOC,ZFPM2,LDLR,NTRK3,ARHGDIA,BMP6,CPXM1,PPIL1,ID4,HAGH,KTN1,MEGF9,ABCA3,RTN1,ACO2,TYMP,CES2,CD163,BIN1,MYC,TGFBR2,NNMT,GDE1,GYPE,NUPR1,STAB1,LILRB5,KIF25,RPAP1,NBAS,TEX264,FMO2,STARD5,ZNF282,VEGFC,THRA,KCNK12,DCHS1,SMUG1,CDC42BPB,TLN2,ABCA8,CHURC1,LRRC25,VPS37A,ESR1,LRRC47,PMEPA1,MAST2,PTGFR,ERAP2,SLC1A4,CDC20,SCARA5,MECR,ZSWIM3,NEURL4,GSTT1,VPS4A,SLC2A3,IRAK1,AHNAK,TIMP1,DNAJC4,COQ8A,MEX3B,HES4,VARS,CIZ1,IARS,ATP13A2,VCAM1,NUSAP1,AP1S2,XRN2,GNAI1,ZFPL1,BSCL2,PSME3,ATIC,NFE2L1,FAIM,SH3PXD2A,SLK,PHF19,VAV3,TBC1D7,GAPVD1,SGK1,SH3GLB1,PCDH7,NCOA7,SLC4A3,CLCNKA,ABCC1,RPS2,ALPK1,TMEM9B,NAT10,SERINC1,MMP2,SCNN1D,LONP2,UBQLN4,DOCK1,SRGAP3,YARS,TRO,RPL6,LRP8,PDGFD,ITGA7,ALDH4A1,RALA,PDDC1,NT5C,PFKL,VCAN,SERTAD4,DCLK2,TRIB1,MTOR,WDFY1,ALDH1A3,DAP3,NAALAD2,EPS15L1,AKR1B15,LPP,SARS,COL18A1,NCKIPSD,PLOD3,DNAH6,CYP11A1,SOX7,GSTM1,CCDC130,EPB41L4B,PCDH9,POLD1,RBM6,ZC2HC1C,ZFP36L2,RUFY3,SYN2,C16orf89,CYP2C8,FZD7,MVD,CYTOR,FNIP2,DYNLT1,COBL,CCNL1,TMED5,MBNL3,LARS,PRND,D2HGDH,LTBR,CLCN3,FAM65B,MYO10,MRPL43,DDX41,PTX3,MGRN1,SPP1,SGCG,ITPR2,LMNA,MYOF,MARS,DPP9,GSR,TRAPPC9,R3HDM4,RGN,THSD7B,RNPEP,COL7A1,LEP,FLRT2,C1QTNF1,BCL2L12,UBASH3B,PNMAL1,RGS12,RAMP2,AADAC,FLNA,HSD11B2,ZNHIT2,RNF144B,MYO16,TMEM132B,SNAPC4,SPOCD1,FRMD1,PHOSPHO2,AP3D1,VWCE,CSF1R,TRMT61A,LRP1B,OLFML2B,NDNF,ZNF585A,MMP9,CARM1,CBX7,TOMM40L,RPE,AXIN1,TPRG1,IL6,POLRMT,CCND3,ATG9A,CSE1L,MAP1A,TMEM219,TNFRSF21,SLC2A5,COMP,COCH,TMEM203,GFM1,ERICH1,PTPN3,PTOV1,EPHX1,CD163L1,EVA1B,COL4A5,HSDL1,DDX3X,SPON1,DTNA,ABCC9,GTF3C1,UCP2,MECOM,KIAA1549L,ZNF521,IGF2R,MYO5A,HNRNPH1,SOX9,GCNA,MXRA5,SOCS3,ARSD,ANKMY1,FCER1A,ZFPM1,AP1B1,GPC3,CEP104,CTSD,TSEN15,ARHGAP20,ACTG2,KMT5A,ELN,CXCL8,NOX4,STXBP1,MAPK8IP2,CBX6,RIMS4,H6PD,FIG4,AKR1B10,TXNRD1,FCN3,ADRA2A,CCDC80,GSDMC,TNS1,SLC11A1,SULF1,PC,COL6A6,ALDH2,DHCR7,SNX16,ERBB2,NDUFV1,PKP1,COL6A2,IPO4,G6PD,AP3B2,POLR3B,COL11A1,PRUNE2,KCND2,RAN,PCDH17,GHITM,NR4A3,EVI5L,LGMN,MKX,RARA,BAALC,KIF21A,MED16,HADHA,ZC3HC1,DKC1,MBD2,ROR1,VPS26B,BCAP29,TSR3,FARSA,AAAS,GAMT,EPB42,PDE1B,FAM71E1,RTN4,ME2,ANG,AKAP12,SQLE,HEATR1,PPP1R3C,SLC1A3,HYOU1,GOLGA3,ATAT1,TRPT1,GPC4,RCOR2,ABCA5,KANSL3,CORO2B,GPIHBP1,TIGD5,C20orf96,ENAH,CELF1,RPUSD3,CES1,JUN,PDE3B,CD24,MORN4,PLXNA1,CEP164,NOL6,PTPRK,ARHGAP4,LRSAM1,PAICS,NBEA,SLIT2,AXL,MRPS18A,GABRE,GBP4,SLC48A1,RHBDD2,GTPBP3,BRINP2,GALE,ANXA3,CILP,NENF,PFN1,FARP1,FAT1,LAMTOR2,CD36,UNC5B,MAP1B,WDR5,CAMK2D,MYOM1,PCYT2,AMPH,GSK3B,RET,HLA-F,EPB41L1,C7orf50,MFSD3,PHACTR3,STX11,HK1,FERMT3,PTPRE,HNMT,TRIOBP,ICA1,PCDHA1,MAPK8IP3,GPAA1,ZNHIT1,FLCN,KIAA0922,RAP1GAP,EXOSC4,RARRES3,IDO1,TBC1D16,XPNPEP1,ARL2,SPIRE1,SRM,SH3RF3,PA2G4,ATF5,SLC4A11,SMO,CFB,STK24,IFRD1,NCL,ATP5I,CHEK2,RHBDD3,COL5A2,METTL1,VSIG4,CIART,TMEM2,GLMP,GBE1,NUCB2,KDR,DHRS7B,KLHDC8B,ANKRD35,WBSCR22,CLIP1,ADCK1,EIF4EBP3,IQCC,KIF1A,KEAP1,ST6GALNAC2,KANK3,HES6,HIPK2,TM6SF1,STK36,PPP1R1B,TMEM201,ANO6,SMG5,MASP1,NPY5R,IFNAR2,TFPI2,HSPA8,TMEM127,CARD9,EVPL,IFT122,CTSA,VARS2,CCDC178,ITGA1,TULP3,MUSTN1,SAMD4A,CHCHD10,OSGIN1,FGF2,SEMA6A,THOC3,ZBTB9,MMP25,SLC35B2,COL16A1,TGM2,CHDH,SORBS1,OSBPL11,CSNK2B,PIK3R2,MAPKAP1,NINL,TOB1,GLG1,FOS,PLA2G4A,HP,SELM,NRXN2,FLNC,ATP1A2,MBD3,ZCWPW1,SLC22A18,TMEM177,TTYH3,SEMA3C,ABCC3,C11orf68,PTER,ABCB6,MT2A,FOXRED1,ATP13A1,PTTG1,MBP,ABCG1,HSPA5,AP2A2,PADI4,KCNAB1,FAR2,CHTF18,CAST,PDZRN3,KCNJ8,MAST4,LAMA2,ENKD1,CAPG,OSBPL7,CYB561,KCNG1,ALG3,SOBP,IGFBP3,AGAP3,MEGF8,TXNRD2,PPAN,LRRC8B,UBXN1,NMT1,TPR,CADPS2,ATF6,KIFC2,HNRNPK,REXO2,MSRB3,SHC1,NET1,ENPP4,MKL2,ENPP2,LRPPRC,MCRS1,MRPL40,LONP1,AGT,ZNF135,ZNF358,NQO1,TUBGCP2,ADGRG1,PIGB,TACC2,KIF5B,ASTN2,HEPACAM,NOP16,SMG7,IVD,DNM1L,PNPLA6,COQ9,SLC29A4,CADM3,APOB,WDR45,HRAS,MYRIP,DGCR6L,PEX16,CCNB1IP1,ANK2,REEP2,IRS2,TXN,EYA2,ARHGEF4,CALCRL,NDRG1,PCSK5,RRBP1,THY1,TNK2,FAM129B,PLOD1,CTPS1,LDOC1,NR1D1,BSG,PTPRB,CDRT1,ADAMTS18,MAP2K3,ZER1,SFRP1,CYR61,MME,SPTBN1,ADAM17,MSC,GRB14,NID2,UHRF1BP1,TNFSF10,TTC1,DCLK1,RPP40,IDH1,UCHL1,COL5A1,EFNB2,PTS,STARD13,CLMN,PSMD14,KIAA0391,LDLRAP1,RASSF5,LBP,PCBP2,PTPRT,AMFR,PI4KA,MYH1,STK19,VPS18,ADRM1,ANGPT1,TWNK,IMPDH2,MGMT,DPAGT1,WDR12,RHPN2,KRT8,PLEKHG6,TF,PPP1R16B,CNN1,ADCY1,DENND1A,ZSCAN18,S1PR1,CBX4,FBN2,ACTR1A,RAB43,EFR3A,RGS1,PHLDA1,DCAKD,TFG,SPHK2,CXCL12,SDC4,DCAF10,FRMD3,CCT8,PLEKHG4,PARVB,TNIP1,SDPR,BRSK1,SLC7A5,PUF60,PDK4,EIF2AK1,PNMA2,AXIN2,TMIE,TEX2,SNRK,PKN1,EPRS,LMCD1,EFS,PPP2R1A,ITGAM,SMOX,GNL3,AK2,NFIX,EPB41L3,CUTA,PKM,ABL1,CDH23,SLC7A1,TET1,QPRT,MYLK,ITGA10,SIL1,HIF1A,ACOT7,CDKN2B,FAM110B,PRKCSH,COL1A2,SEPHS2,NFX1,HMOX1,NKD2,AEBP1,PCK2,KCNMA1,C7,POLN,KIT,ARHGEF2,NR2F6,CUL9,ALPL,STK40,HMGCS1,ACTN1,PRNP,CYP27A1,CXCR4,COPS7A,SCIN,ZBTB7C,SLC7A8,CCDC3,WARS,DIP2C,LPAR1,EDNRA,ELK1,RTN3	1022	
Renal Necrosis/Cell Death	cell death	cell death of kidney cell lines	4.37E-05	 	-1.520	 	-2.725	RFXANK,ADRBK1,CA4,HSPA1A/HSPA1B,UNC5B,HRAS,HSPA5,MYC,SGPL1,IKBKG,MCOLN3,ZHX2,ABCC1,NEO1,GSK3B,HIPK2,BIRC3,MCL1,HK1,PTGIS,TJP2,COMP,SPP1,ATG7,TNFRSF10B,GNG2,UNC13B,PAWR,PTGDS,IER3,HAX1,BCL2L1,NOL3,TRIM39,PKD1,PPP1R15A,IGFBP3,GAPDH,TFRC,ALDH3B1,ESR1,RBP4,FYN,DDIT3,GSTM5,ERN1,HYOU1,TNFSF10,CASP4,ATF6,NFKBIA,STUB1,DAP3,ERBB2,RASSF5,NDUFAB1,RAD21,ATP13A2,ATN1,PRNP,AGT,NLRP3,EMP3,SMAD7,TRIB3,SRXN1,PRMT1,SLK,EMP1,FOS,PLA2G4A,PMP22,MYOC,NTRK3,CAT,LYN,PEA15,BNIP3L,MAP3K8,TNFRSF19,P2RX7,SLC47A1	82	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart cells	7.20E-05	 	0.279	 	-0.137	KCND2,CTGF,LEP,BMP4,FGF2,GDF15,CACNA1H,ADIPOQ,TNFAIP3,IL6,SLC9A1,H2AFZ,GPX3,SHC1,CTSD,DUSP5,MTOR,NFKBIA,CAMK2D,JUN,PLCE1,MYOM1,EDN1,TIMP1,CAV1,GSK3B,ADORA1,AGT,NOX4,CMKLR1,ATF3,EPAS1,SMAD7,HBEGF,IER3,IGF2R,LMCD1,DUSP1,CTSB,EDNRA,MAP2K3,MAPK7,MAP2K5,MMP9,mir-21	45	
Liver Steatosis	hepatic steatosis	hepatic steatosis	8.38E-05	 	-1.660	 	-0.403	APOB,CD36,PLA2G15,RGCC,LIPE,ABCG1,IL6,PNRC2,POR,IKBKG,LPIN1,CAV1,ATF4,IRS2,KLF2,HADHA,RBM38,SPP1,GPS2,CIDEC,HBEGF,LMNA,THRA,IFNAR2,GPX7,PANK1,ERCC1,DUSP1,SLC22A5,HIF1AN,RGN,CD14,ACACA,ADIPOR2,ESR1,VHL,mir-21,APOE,LEP,DDIT3,GNA11,ADIPOQ,CTHRC1,ATF6,ID1,HMOX1,MAN2C1,TIPARP,CCL2,CSPG4,PDE3B,PLIN2,ACSL4,LBP,ADORA1,ACADM,PTGER4,SLC25A13,ABHD5,EPAS1,UCP2,UPP1,RGS16,BSCL2,CCDC3,POLD1,PSME3,NFE2L1,EBF1,KRT8,LDLR,ACADVL,CBS/CBSL,CAT	74	
Pulmonary Hypertension	pulmonary hypertension	Pulmonary Hypertension	9.63E-05	 	-0.895	 	-0.779	APOE,FHL1,KCNK3,ITSN1,ABL1,TNFSF10,SLC9A1,G6PC3,F8,EDN1,CSF2RA,CAV1,KIT,RET,SARS2,ADRB2,MIF,EPAS1,ANGPT1,CXCR4,ATP2C1,CSF1R,BCL2L1,NPR3,ADRA2A,EDNRA,KDR	27	
Liver Necrosis/Cell Death	cell death	cell death of liver	1.11E-04	 	-0.572	 	0.327	SOCS3,ADRBK1,HRAS,IL6,TAF10,MYC,IKBKG,TNIP1,GSK3B,LTBR,BIRC3,MCL1,SELE,HBEGF,IER3,BCL2L1,ERCC1,CTSB,CD14,RGN,ESR1,ADM,MME,SPTBN1,APOE,GADD45B,DDIT3,ABL1,ADIPOQ,TNFSF10,FKBP1A,SMPD1,IRF3,NGF,SLC19A3,HMOX1,ALDH2,SHC1,MTOR,NFKBIA,JUN,TIMP1,FLNA,SAA1,NCL,RHBDD3,SLC20A1,FAAH,MYCN,TYROBP,NFE2L1,FAIM,RBCK1,FOS,LAMP2,KRT8,LDLR,CBS/CBSL,SERPINH1,BMF,CAT,MAP3K8,PTGS2,DNM1L,MMP9	65	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells	1.26E-04	 	0.587	 	-0.147	SPP1,LEP,CTGF,LEPR,ADIPOQ,CXCL12,HBEGF,SMPD1,IL6,COL1A1,EDN1,TF,TIMP1,SERPINH1,CTSB,EDNRA,PTGS2,AGT	18	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver	1.27E-04	 	-0.874	 	-0.444	ADM,SPTBN1,SOCS3,GADD45B,ADRBK1,ADIPOQ,TNFSF10,HRAS,SMPD1,IL6,IRF3,TAF10,NGF,MYC,SHC1,ALDH2,TNIP1,IKBKG,MTOR,NFKBIA,JUN,TIMP1,SAA1,GSK3B,NCL,BIRC3,MCL1,SLC20A1,MYCN,HBEGF,NFE2L1,FAIM,RBCK1,BCL2L1,KRT8,ERCC1,LDLR,CBS/CBSL,SERPINH1,BMF,CAT,CTSB,RGN,PTGS2,MMP9	45	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cell lines	1.45E-04	 	-1.490	 	-2.488	RFXANK,ADRBK1,CA4,HSPA1A/HSPA1B,UNC5B,HRAS,HSPA5,MYC,SGPL1,MCOLN3,ABCC1,ZHX2,GSK3B,HIPK2,BIRC3,MCL1,PTGIS,TJP2,SPP1,COMP,TNFRSF10B,UNC13B,GNG2,PAWR,IER3,PTGDS,HAX1,BCL2L1,NOL3,TRIM39,PKD1,PPP1R15A,IGFBP3,TFRC,ESR1,RBP4,DDIT3,HYOU1,TNFSF10,CASP4,ATF6,NFKBIA,STUB1,DAP3,ERBB2,RASSF5,RAD21,ATN1,AGT,NLRP3,SMAD7,TRIB3,SRXN1,PRMT1,SLK,FOS,MYOC,CAT,LYN,PEA15,BNIP3L,MAP3K8,TNFRSF19,P2RX7	64	
Liver Necrosis/Cell Death	necrosis	necrosis of liver	1.61E-04	 	-0.403	 	0.478	SOCS3,ADRBK1,HRAS,IL6,MYC,IKBKG,TNIP1,GSK3B,LTBR,BIRC3,MCL1,SELE,HBEGF,IER3,BCL2L1,ERCC1,CTSB,CD14,RGN,ESR1,ADM,SPTBN1,MME,APOE,GADD45B,DDIT3,ABL1,ADIPOQ,TNFSF10,FKBP1A,SMPD1,IRF3,NGF,SLC19A3,HMOX1,ALDH2,SHC1,MTOR,NFKBIA,JUN,TIMP1,FLNA,SAA1,NCL,RHBDD3,SLC20A1,FAAH,MYCN,TYROBP,NFE2L1,FAIM,RBCK1,FOS,LAMP2,KRT8,LDLR,CBS/CBSL,SERPINH1,BMF,CAT,MAP3K8,PTGS2,DNM1L,MMP9	64	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiomyocytes	2.30E-04	 	0.276	 	-0.101	KCND2,CTGF,LEP,BMP4,FGF2,GDF15,CACNA1H,ADIPOQ,TNFAIP3,IL6,H2AFZ,SLC9A1,SHC1,DUSP5,MTOR,NFKBIA,CAMK2D,PLCE1,EDN1,TIMP1,CAV1,GSK3B,ADORA1,AGT,NOX4,ATF3,SMAD7,HBEGF,IER3,IGF2R,LMCD1,DUSP1,EDNRA,MAP2K3,MAPK7,MMP9,mir-21,MAP2K5	38	
Renal Atrophy	atrophy	atrophy of renal cortex	2.53E-04	 	 	 	 	PTGIS,LGMN,ADAMTS1,PTGS2,GPC3,APRT,AGT	7	
Cardiac Arteriopathy	vasospasm	vasospasm of coronary artery	3.33E-04	 	 	 	 	KCNJ8,SGCG,ABCC9,SGCD,AGT	5	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cells	3.46E-04	 	-0.595	 	-0.208	ADM,SPTBN1,SOCS3,GADD45B,ADRBK1,ADIPOQ,TNFSF10,HRAS,SMPD1,IL6,IRF3,NGF,MYC,SHC1,ALDH2,TNIP1,IKBKG,MTOR,NFKBIA,JUN,TIMP1,SAA1,GSK3B,NCL,BIRC3,MCL1,SLC20A1,MYCN,HBEGF,FAIM,RBCK1,BCL2L1,KRT8,ERCC1,LDLR,CBS/CBSL,SERPINH1,BMF,CAT,CTSB,RGN,PTGS2,MMP9	43	
Cardiac Hypertrophy	ventricular hypertrophy	ventricular hypertrophy	3.80E-04	 	-0.803	 	0.094	KCND2,APOE,LEP,CXCL12,FKBP1A,TPM1,IL6,HIF1A,ATP2A2,DUSP5,MTOR,PLCE1,EDN1,GAA,CAV1,GSK3B,CASQ2,ADRB2,PLAT,AGT,EPAS1,RNLS,ATF3,GUCY1A3,SMAD7,IER3,HMGA1,RCAN1,PLA2G4A,PBX3,ADRA2A,VAV3,MAPK7,PTGS2,ADRA1A	35	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatocytes	4.20E-04	 	-0.854	 	-0.540	SPTBN1,SOCS3,GADD45B,ADRBK1,ADIPOQ,TNFSF10,HRAS,SMPD1,IL6,IRF3,MYC,SHC1,ALDH2,TNIP1,MTOR,IKBKG,NFKBIA,JUN,SAA1,GSK3B,NCL,BIRC3,MCL1,SLC20A1,MYCN,FAIM,RBCK1,BCL2L1,KRT8,ERCC1,LDLR,CBS/CBSL,BMF,CAT,CTSB,RGN,PTGS2	37	
Pulmonary Hypertension	pulmonary hypertensive arterial disease	pulmonary hypertensive arterial disease	4.23E-04	 	-1.154	 	-1.262	APOE,FHL1,EPAS1,KCNK3,ITSN1,ABL1,TNFSF10,CSF1R,G6PC3,BCL2L1,EDN1,CSF2RA,CAV1,KIT,EDNRA,RET,KDR	17	
Liver Necrosis/Cell Death	cell death	cell death of liver cells	5.21E-04	 	-0.156	 	0.083	SPTBN1,ADM,APOE,SOCS3,GADD45B,DDIT3,ADRBK1,ADIPOQ,TNFSF10,HRAS,SMPD1,IRF3,IL6,NGF,MYC,HMOX1,SHC1,ALDH2,MTOR,TNIP1,IKBKG,JUN,NFKBIA,TIMP1,SAA1,LTBR,GSK3B,NCL,BIRC3,MCL1,SLC20A1,FAAH,MYCN,HBEGF,IER3,FAIM,RBCK1,BCL2L1,FOS,LAMP2,ERCC1,LDLR,KRT8,CBS/CBSL,SERPINH1,BMF,CAT,CTSB,RGN,PTGS2,DNM1L,MMP9	52	
Liver Necrosis/Cell Death	cell death	cell death of hepatocytes	5.28E-04	 	-0.193	 	-0.004	SPTBN1,SOCS3,GADD45B,DDIT3,ADRBK1,ADIPOQ,TNFSF10,HRAS,SMPD1,IL6,IRF3,MYC,HMOX1,SHC1,ALDH2,TNIP1,IKBKG,MTOR,NFKBIA,JUN,SAA1,GSK3B,NCL,BIRC3,MCL1,FAAH,SLC20A1,MYCN,FAIM,RBCK1,FOS,BCL2L1,KRT8,ERCC1,LDLR,CBS/CBSL,BMF,CAT,CTSB,RGN,PTGS2,DNM1L	42	
Cardiac Necrosis/Cell Death	cell death	cell death of heart	6.90E-04	 	0.244	 	1.071	SOCS3,CTSG,IL6,IKBKG,CAMK2D,SPTLC2,PLA2G5,GSK3B,HADHA,MCL1,HK1,CALCRL,NOX4,SPP1,MMP2,THBD,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADM,SFRP2,LEP,FGF2,LEPR,ADIPOQ,TNFAIP3,HIF1A,IRAK1,HMOX1,EDN1,TIMP1,HSPE1,NCL,MAPKAPK2,ABCC9,ADRB2,AGT,PLAT,S100A1,THBS4,ANGPT1,CSK,MT1A,CAT,BNIP3L,PIN1,SGCD,ADRA1A,MAOA	58	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of renal glomerulus	7.22E-04	 	1.157	 	1.704	SRC,NOX4,EDN1,LEPR,RARA,CAT,LYN,ADIPOQ,NUPR1,SMAD7,STAB1,PTGS2,ESR1,AGT	14	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiac muscle	7.63E-04	 	0.068	 	-0.438	KCND2,CTGF,LEP,BMP4,PFKFB1,FGF2,GDF15,CACNA1H,ADIPOQ,TNFAIP3,IL6,SLC9A1,H2AFZ,SHC1,NR4A3,DUSP5,MTOR,NFKBIA,CAMK2D,PLCE1,EDN1,TIMP1,CAV1,GSK3B,HEY2,ADORA1,AGT,NOX4,ATF3,P2RX4,SMAD7,HBEGF,IER3,IGF2R,LMCD1,DUSP1,EDNRA,MAP2K3,MAPK7,MMP9,mir-21,MAP2K5	42	
Cardiac Arteriopathy	coronary artery disease	coronary artery disease	7.70E-04	 	-0.590	 	-0.078	RGS1,HCAR3,APOB,ACAT2,CD36,ABCG1,IL6,CD163,GSS,SLC9A1,NNMT,GAA,TUBA1C,KLF2,CERS6,KCNJ8,SELE,SGCG,TUBB2A,SCNN1D,ITGAM,ADRA2A,NPR3,VKORC1,MATN2,ASIC1,CD14,LRP8,SAMD4A,APOE,ADAMTS7,CCDC167,ADIPOQ,QPRT,FKBP1A,LRRC20,CD55,MTOR,EDN1,CCL2,SORBS1,THBS1,PDE3B,ADORA1,ABCC9,HCAR2,ALDH5A1,ADRB2,AGT,SNAPC4,PARVA,COL5A2,MECOM,ATP2C1,TUBG1,FRMD4A,GABRE,PLA2G2A,FOS,MTHFD1L,SUPV3L1,LAMP2,LDLR,PBX3,ASTN2,S1PR1,GBE1,MSRA,PTGS2,KDR,SGCD	71	
Renal Proliferation	cell proliferation	cell proliferation of kidney cell lines	7.94E-04	 	0.358	 	-0.145	LOX,SOCS3,RALA,KLF6,UNC5B,TTLL4,HRAS,CES2,MMP25,EIF4EBP1,HSPA4,MTOR,JUN,PLCE1,TSC2,CSTF2,CD24,CDCA5,ERBB2,RET,NCL,NDUFAB1,PFKFB3,UBE2M,TJP1,NINL,LMNA,PLAUR,CCDC8,CSF1R,GRN,FOS,PPP2R1A,PMP22,SDCBP,MYOC,PKD1,ADCY1,ZSCAN18,RARRES3,TAZ,PTGS2,ESR1,P2RX7,QPCT,FBN2	46	
Renal Necrosis/Cell Death	cell death	cell death of renal glomerulus	9.98E-04	 	-0.028	 	0.045	APOE,GFPT1,CTGF,ATF3,FGF2,SMAD7,LRRK2,C1QA,ATF6,SLK,NFKBIA,EDN1,DUSP1,PRKCD,ITGA1,PTGS2,PLAT,AGT	18	
Cardiac Necrosis/Cell Death	necrosis	necrosis of cardiac muscle	9.99E-04	 	0.198	 	0.964	SOCS3,CTSG,IL6,IKBKG,CAMK2D,SPTLC2,PLA2G5,GSK3B,HADHA,MCL1,HK1,CALCRL,NOX4,SPP1,MMP2,THBD,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADM,LEP,FGF2,LEPR,ADIPOQ,TNFAIP3,HIF1A,IRAK1,HMOX1,EDN1,TIMP1,HSPE1,NCL,MAPKAPK2,ABCC9,ADRB2,AGT,PLAT,S100A1,ANGPT1,CSK,MT1A,CAT,BNIP3L,SGCD,ADRA1A,MAOA	55	
Cardiac Necrosis/Cell Death	cell death	cell death of heart cells	1.33E-03	 	-0.040	 	0.719	SOCS3,CTSG,IL6,IKBKG,CAMK2D,SPTLC2,PLA2G5,GSK3B,HADHA,MCL1,HK1,CALCRL,NOX4,SPP1,MMP2,THBD,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADM,SFRP2,LEP,FGF2,LEPR,ADIPOQ,TNFAIP3,HIF1A,IRAK1,HMOX1,EDN1,TIMP1,HSPE1,NCL,MAPKAPK2,ABCC9,ADRB2,AGT,S100A1,ANGPT1,CSK,MT1A,CAT,BNIP3L,PIN1,ADRA1A,MAOA	55	
Cardiac Hypoplasia	hypoplasia	hypoplasia of trabeculae carne	1.39E-03	 	-0.437	bias	1.339	MYCN,MECOM,PKP2,ADRBK1,TGFBR3,GNA11,SHC1,MAPK7,HEY2,TXNRD2,NOTCH1,HEY1,RBP4	13	
Cardiac Hypertrophy	hypertrophy	hypertrophy of right ventricle	1.60E-03	 	-0.166	bias	0.760	APOE,PLA2G4A,EPAS1,PBX3,GUCY1A3,GAA,CAV1,CXCL12,IL6,PTGS2	10	
Cardiac Necrosis/Cell Death	cell death	cell death of cardiomyocytes	1.81E-03	 	0.182	 	0.887	SOCS3,CTSG,IL6,IKBKG,CAMK2D,SPTLC2,PLA2G5,GSK3B,HADHA,MCL1,HK1,CALCRL,NOX4,SPP1,MMP2,THBD,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADM,LEP,FGF2,LEPR,ADIPOQ,TNFAIP3,HIF1A,IRAK1,HMOX1,EDN1,TIMP1,HSPE1,NCL,MAPKAPK2,ABCC9,ADRB2,AGT,S100A1,ANGPT1,CSK,MT1A,CAT,BNIP3L,ADRA1A,MAOA	53	
Liver Fibrosis	fibrosis	fibrosis of liver	1.85E-03	 	-1.847	 	-1.322	SOCS3,APOE,LEP,DDIT3,SMPD1,IL6,HDGF,TGFBR2,COL1A2,HMOX1,JUN,TIMP1,STAB1,CCR1,MIF,SPP1,SMAD7,PLAUR,IFNAR2,POLD1,NFE2L1,COL1A1,HP,XYLT2,LDLR,CBS/CBSL,GLMP,CTSB,SPARC,NAGLU,DNM1L,mir-21,COL3A1	33	
Renal Hypertrophy	hypertrophy	hypertrophy of kidney	1.88E-03	 	0.846	 	1.336	SRC,NOX4,EDN1,LEPR,RARA,CAT,SMAD7,ADIPOQ,LYN,NUPR1,STAB1,HSD11B2,PTGS2,ESR1,AGT	15	
Liver Proliferation	proliferation	proliferation of liver cells	1.95E-03	 	0.924	 	0.022	SPTBN1,SOCS3,CTGF,LEP,BMP4,LEPR,ADIPOQ,CXCL12,HRAS,MST1,SMPD1,IL6,GPC3,ODC1,TNFRSF12A,MYC,TGFBR2,NFKBIA,JUN,EDN1,CCND3,TIMP1,THBS1,RARA,CXCL14,SMARCB1,CAV1,SLC7A5,GSK3B,SULF2,AGT,SLC20A1,SPP1,FST,CXCR4,SMAD7,HBEGF,TOB1,FOS,COL1A1,ERCC1,TF,SERPINH1,CTSB,EDNRA,PTGS2,mir-21	47	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of cardiomyocytes	2.07E-03	 	0.569	 	1.245	ADM,SOCS3,LEP,LEPR,FGF2,CTSG,ADIPOQ,TNFAIP3,IL6,HIF1A,IRAK1,HMOX1,IKBKG,CAMK2D,EDN1,SPTLC2,PLA2G5,HSPE1,GSK3B,MAPKAPK2,ADRB2,MCL1,AGT,S100A1,NOX4,CALCRL,SPP1,CSK,MMP2,THBD,MT1A,PKN1,BCL2L1,NOL3,PRKCD,CAT,RTN4,GAPDH,BNIP3L,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADRA1A,MAOA	46	
Pulmonary Hypertension	primary pulmonary hypertension	primary pulmonary hypertension	2.13E-03	 	 	 	 	BCL2L1,FHL1,EPAS1,EDN1,KCNK3,CSF2RA,CAV1,KDR	8	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart cells	2.15E-03	 	0.458	 	1.159	ADM,SOCS3,LEP,SFRP2,LEPR,FGF2,CTSG,ADIPOQ,TNFAIP3,IL6,HIF1A,IRAK1,HMOX1,IKBKG,CAMK2D,EDN1,SPTLC2,PLA2G5,HSPE1,GSK3B,MAPKAPK2,ADRB2,MCL1,AGT,S100A1,NOX4,CALCRL,SPP1,CSK,MMP2,THBD,MT1A,PKN1,BCL2L1,NOL3,PRKCD,CAT,RTN4,GAPDH,BNIP3L,MAP2K3,MDK,CYR61,ADRA1A,mir-21,MAP2K5,MAOA	47	
Cardiac Arteriopathy	premature coronary artery disease	early-onset premature coronary artery disease	2.41E-03	 	 	 	 	RGS1,LDLR,ABCG1,LRP8,ADRB2	5	
Renal Inflammation, Renal Nephritis	pyelonephritis	pyelonephritis	2.41E-03	 	 	 	 	CXCL8,IL6,PTGS2,KDR,APRT	5	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal glomerulus	2.56E-03	 	0.006	 	-0.108	APOE,GFPT1,CTGF,ATF3,FGF2,SMAD7,LRRK2,C1QA,SLK,NFKBIA,EDN1,DUSP1,PRKCD,ITGA1,PTGS2,AGT	16	
Renal Inflammation, Renal Nephritis	Goodpasture's syndrome	Goodpasture's syndrome	3.02E-03	 	 	 	 	DDIT3,IDO1,ASNS	3	
Renal Damage	damage	damage of kidney	3.41E-03	 	1.180	 	0.557	ADM,APOE,LEP,BMP4,FGF2,LEPR,UNC5B,RGCC,MST1,C1QA,IL6,CD55,EDN1,THBS1,CFB,ADORA1,PLAT,AGT,CCR1,MIF,C5AR1,SMAD7,PLAUR,HBEGF,LRRK2,TRIM69,DUSP1,CAT,ARHGDIA,MAP2K3,MDK,mir-21,CYP2C8	33	
Cardiac Proliferation	proliferation	proliferation of heart cells	3.58E-03	 	0.441	 	0.071	ADAM17,LEP,FGF2,TGFBR3,ADIPOQ,CDK4,IL6,AKIP1,TGFBR2,HMOX1,PLCE1,EDN1,RARA,KIT,HSD11B2,HEY2,GSK3B,AGT,MYCN,CALCRL,HBEGF,DUSP1,ALDH1A2,GNL3,DNAJB6,RBP4	26	
Congenital Heart Anomaly	ventricular septal defect	ventricular septal defect	3.95E-03	 	0.312	bias	2.494	ADAM17,CFC1/CFC1B,TGFBR3,CXCL12,CDK4,FKBP1A,GPC3,ATP2A2,JUN,EDN1,FLNA,RARA,MKL2,SLC19A1,HEY2,CYP51A1,DHRS3,CXCR4,SMAD7,DOCK1,DVL2,ZFPM2,PKD1,NTRK3,EDNRA,DVL3,MEGF8	27	
Liver Cirrhosis	primary biliary cirrhosis	primary biliary cirrhosis	4.39E-03	 	 	 	 	C5AR1,CTGF,APOB,SPP1,SLC4A2,FST,FRZB,CXCR4,NQO1,TNFSF10,MNDA,HNRNPK,GLG1,LDLR,CCL8,BSG,CCL2,CSF2RA,ABCC1,CD86,ABCC3,ALPL,NOTCH1,COL3A1	24	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular myocytes	4.56E-03	 	-1.151	 	-1.416	KCND2,DUSP5,MTOR,PLCE1,LEP,EDN1,SMAD7,GSK3B,AGT	9	
Renal Dilation	dilation	dilation of kidney	4.78E-03	 	-1.387	bias	-0.601	ADM,PKD1,EDNRA,PRKCSH,AGT	5	
Congenital Heart Anomaly	heart septal defect	heart septal defect	5.54E-03	 	-0.009	bias	2.229	ADAM17,CFC1/CFC1B,TGFBR3,CXCL12,CDK4,FKBP1A,GPC3,ATP2A2,JUN,EDN1,FLNA,RARA,MKL2,SLC19A1,HEY2,CYP51A1,DHRS3,CXCR4,SMAD7,DOCK1,DVL2,ZFPM2,PKD1,ADRA2A,NTRK3,EDNRA,DVL3,MEGF8	28	
Glomerular Injury, Renal Necrosis/Cell Death	necrosis	necrosis of renal glomerulus	5.54E-03	 	-0.249	 	-0.400	APOE,GFPT1,ATF3,CTGF,FGF2,SMAD7,ATF6,SLK,NFKBIA,EDN1,DUSP1,PRKCD,PTGS2,PLAT,AGT	15	
Liver Hypoplasia	hypoplasia	hypoplasia of liver	6.19E-03	Decreased	-2.537	bias	-0.767	LIG1,SPTBN1,SLC20A1,MYCN,TCEA1,ERN1,CDK4,CTHRC1,EIF6,MAFG,TNIP1,TSC2,ATF4	13	
Renal Damage	injury	injury of kidney	6.21E-03	 	0.718	 	0.242	ADM,CCR1,C5AR1,LEP,BMP4,FGF2,UNC5B,SMAD7,MST1,IL6,TRIM69,CD55,THBS1,CAT,CFB,ARHGDIA,MAP2K3,ADORA1,mir-21,PLAT,CYP2C8,AGT	22	
Cardiac Proliferation	proliferation	proliferation of cardiomyocytes	6.21E-03	 	0.264	 	0.120	MYCN,CALCRL,ADAM17,LEP,TGFBR3,CDK4,IL6,AKIP1,TGFBR2,HMOX1,PLCE1,EDN1,DUSP1,RARA,ALDH1A2,KIT,HSD11B2,GSK3B,HEY2,DNAJB6,AGT,RBP4	22	
Glomerular Injury	glomerulosclerosis	glomerulosclerosis	6.33E-03	 	-1.050	bias	0.395	ADM,FYN,APOE,RRM2B,ADIPOQ,APRT,HMOX1,MAN2C1,LGMN,CCL2,STAB1,AGT,CCR1,PTGIS,SPP1,MTSS1,SGCG,SMAD7,HBEGF,MMP2,STC1,XYLT2,PKD1,VAV3,LYN,SPARC,ARHGDIA,ITGA1,PTGS2,TNS1,MPV17,mir-21	32	
Increased Levels of Potassium	excretion	increased excretion of K+	6.74E-03	 	 	 	 	LEP,ADAMTS1,VAV3,SLC4A11,HSD11B2,AKR1B1,AGT	7	
Cardiac Arrythmia	cardiac fibrillation	cardiac fibrillation	7.05E-03	 	 	 	 	KCNJ2,KCNK3,SNTA1,IL6,ATP2A2,TGM2,CCL2,TIMP1,KCNMA1,TUBA1C,ABCC9,ADRA1B,ADRB2,PLAT,KCNJ8,VCAM1,NUP155,PKP2,TUBG1,TUBB2A,DGAT2,LMNA,THRA,VKORC1,ADRA2A,ATP1A2,PTGS2,P2RX7,MMP9,ADRA1A,COL3A1,MAOA	32	
Cardiac Fibrosis	fibrosis	fibrosis of heart	7.63E-03	 	0.683	 	1.664	APOE,PFKFB1,RRM2B,CACNA1H,PPP1CB,HRAS,TNFAIP3,IRF3,ATP2A2,DTNA,HMOX1,RGS5,TIMP1,PNKD,CAV1,GSK3B,HEY2,ADORA1,ACADM,ADRB2,PLAT,AGT,PTX3,NOX4,NLRP3,SPP1,ATF3,SGCG,EGR1,HBEGF,LMNA,SGCB,PLA2G2A,CAPNS1,NOL3,ADRA2A,LIMS1,VAV3,TSC22D1,PTGS2,SGCD,mir-21,MMP9	43	
Glomerular Injury, Renal Necrosis/Cell Death	cell death	cell death of glomerular cells	7.93E-03	 	-0.480	 	-0.750	SLK,APOE,GFPT1,ATF3,CTGF,NFKBIA,EDN1,FGF2,DUSP1,PRKCD,SMAD7,ATF6,PTGS2,AGT	14	
Cardiac Hypoplasia	hypoplasia	hypoplasia of heart ventricle	8.08E-03	 	-0.987	bias	0.769	MYCN,ADRBK1,PKP2,MECOM,TGFBR3,GNA11,SHC1,ZFPM2,HEY2,MAPK7,NOTCH1,TXNRD2,CYP51A1,HEY1,RBP4	15	
Kidney Failure	failure	failure of kidney	8.72E-03	 	0.153	bias	1.565	APOB,RRM2B,ELANE,MST1,GSS,APRT,LGMN,SARS2,ADRA1B,CXCL8,SPP1,ATF3,SGCG,GUCY1A3,MMP2,PTGDS,STC1,ITGAM,PKD1,NPR3,ADRA2A,DUSP1,IDO1,ITGA1,MDK,CYR61,TNS1,ADM,ADIPOQ,FKBP1A,GSTT1,HMOX1,MTOR,GBA,EDN1,PDE3B,THBS1,CFB,ADORA1,FCGR3A/FCGR3B,AGT,ADRB2,GSTM1,IMPDH2,ATP2C1,AQP11,GABRE,LDLR,FCER1G,ARHGDIA,PTGS2,ADRA1A	52	
Heart Failure	failure	failure of heart	9.09E-03	 	-1.072	bias	0.450	CTGF,ADRBK1,CD36,CA4,CA5B,CA12,IL6,GSS,ATP2A2,SLC9A1,IDUA,IKBKG,CAMK2D,CAV1,ANK2,STAB1,HEY2,BIRC3,ADRA1B,MCL1,CSF3R,GUCY1A3,ITPR2,GRK5,SCNN1D,BCL2L1,PPP2R1A,NPR3,ADRA2A,PTPA,ASIC1,mir-21,ADM,AOC3,ADIPOQ,CDK4,FKBP1A,CA3,MTOR,TIMP1,PDE3B,CST3,CYP51A1,PTGER4,ADRB2,MYCN,SLC12A2,IGF2R,CAPNS1,ZFPM2,TF,LIMS1,ATP1A2,SOX9,TAZ,PTGS2,DSG2,MMP9,ADRA1A	59	
Liver Necrosis/Cell Death	cell death	cell death of hepatic stellate cells	9.12E-03	 	-0.046	 	-0.243	FAAH,TIMP1,SERPINH1,ADIPOQ,TNFSF10,HBEGF,NGF,MMP9	8	
Congenital Heart Anomaly	congenital heart disease	congenital heart disease	9.22E-03	 	-0.275	bias	2.354	KCNJ2,TGFBR3,SNTA1,CXCL12,NCSTN,IL6,GPC3,ATP2A2,WDR5,PLCE1,RARA,ANK2,HEY2,CXCL8,THRA,DOCK1,IFT122,DVL2,PKD1,ADRA2A,ALDH1A2,B3GAT3,MAPK7,MEGF8,NOTCH1,NRP1,ADAM17,CFC1/CFC1B,CDK4,FKBP1A,NAA10,COL1A2,DTNA,JUN,SH3PXD2B,EDN1,FLNA,MKL2,SLC19A1,GNG5,CYP51A1,FCGR3A/FCGR3B,DHRS3,CXCR4,SMAD7,ZFPM2,NTRK3,EDNRA,DVL3,CHD7	50	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cells	9.37E-03	 	-0.729	 	-0.917	APOE,GFPT1,NLRP3,CTGF,ATF3,DDIT3,FGF2,AQP11,UNC5B,SMAD7,MST1,HIF1A,SLK,NFKBIA,EDN1,DUSP1,PRKCD,PTGS2,SFRP1,ADORA1,mir-21,AGT	22	
Cardiac Stenosis	stenosis	stenosis of semilunar valve	9.58E-03	 	1.039	bias	2.070	SELE,VCAM1,APOB,SPP1,ATP2C1,HBEGF,MMP2,GABRE,PLCE1,LDLR,NTRK3,TIMP1,HEY2,MMP9	14	
Liver Cirrhosis	cirrhosis	Cirrhosis	1.04E-02	 	 	 	 	ADAM17,CTGF,APOB,LEP,SLC4A2,FRZB,TNFSF10,UTP4,IL6,HNRNPK,CCL8,CCL2,TIMP1,CSF2RA,ABCC1,GCLM,ALPL,ADRA1B,ADRB2,AGT,CCR1,CSF3R,CXCL8,C5AR1,SPP1,FST,ADAMTS1,CXCR4,EGR1,NQO1,MMP2,MNDA,IFNAR2,GLG1,COL1A1,KRT8,LDLR,TF,VKORC1,BSG,SPARC,CD86,ABCC3,NOTCH1,ADRA1A,MMP9,COL3A1	47	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	quantity	quantity of hepatocellular carcinoma	1.06E-02	 	 	 	 	TGFBR2,IKBKG,JUN,LEP	4	
Cardiac Necrosis/Cell Death	necrosis	necrosis of myocardium	1.08E-02	 	 	 	 	THBD,SGCD,PLAT	3	
Cardiac Damage	damage	damage of cardiac muscle	1.09E-02	 	0.076	bias	0.829	GDF15,CAV1,ADIPOQ,TXN,SGCD,HADHA,mir-21,PDCD4,AGT	9	
Liver Inflammation/Hepatitis	inflammation	inflammation of liver	1.18E-02	 	-0.396	 	1.098	APOB,C10orf54,IL6,SPI1,POR,IKBKG,LPIN1,GAA,STAB1,LTBR,BIRC3,CSF3R,CXCL8,CLEC4G,SPP1,SHARPIN,TNFRSF10B,MMP2,THOP1,IFNAR2,BCL2L1,EFS,NAGLU,CD14,CYR61,ADIPOR2,ESR1,COL3A1,AKAP12,APOE,LEP,DDIT3,ZFP36,SCARA5,ADIPOQ,TNFSF10,TNFAIP3,FKBP1A,SLC19A3,HMOX1,CD55,MTOR,CCL8,CCL2,CCL3L3,STUB1,TIMP1,PDE3B,ADORA1,FCGR3A/FCGR3B,RHBDD3,NLRP3,TYROBP,IMPDH2,EGR1,PLAUR,POLD1,NFE2L1,FAIM,HP,KRT8,LDLR,CBS/CBSL,LYN,SPARC,CXCL2,MMP9	67	
Kidney Failure	acute renal failure	acute renal failure	1.35E-02	 	 	 	 	SPP1,ATF3,ELANE,MST1,GSS,HMOX1,ITGAM,EDN1,NPR3,ADRA2A,CYR61,ADORA1,ADRA1B,ADRA1A,ADRB2	15	
Liver Failure	failure	failure of liver	1.35E-02	 	0.447	bias	1.354	ADAM17,NBAS,IL6,MARS,GSS,FAIM,HMOX1,LARS,EDN1,ADRA2A,DUSP1,TIMP1,ADRA1B,ADRA1A,ADRB2	15	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of glomerular cells	1.37E-02	 	-0.227	 	-0.577	SLK,APOE,GFPT1,ATF3,CTGF,NFKBIA,EDN1,FGF2,DUSP1,PRKCD,SMAD7,PTGS2,AGT	13	
Cardiac Stenosis	stenosis	stenosis of aortic valve	1.37E-02	 	0.447	bias	1.354	SELE,VCAM1,APOB,SPP1,ATP2C1,HBEGF,MMP2,GABRE,PLCE1,LDLR,TIMP1,HEY2,MMP9	13	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia	catecholaminergic polymorphic ventricular tachycardia	1.41E-02	 	 	 	 	KCNJ2,ANK2,LMNA,TPM1,DSG2,CASQ2	6	
Renal Damage, Renal Tubule Injury	damage	damage of tubulointerstitium	1.41E-02	 	 	 	 	CCR1,APOE,EDN1,HBEGF,PLAUR,MDK	6	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of mesangial cells	1.41E-02	 	1.276	 	0.730	SRC,EDN1,CAT,NUPR1,SMAD7,AGT	6	
Increased Levels of LDH	release	increased release of LDH	1.41E-02	 	 	 	 	HMOX1,EDN1,ELANE,EDNRA,SLC9A1,KLF4	6	
Liver Adhesion	adhesion	adhesion of liver cells	1.88E-02	 	 	 	 	VCAM1,KRT8,CTGF,ITGAM	4	
Cardiac Fibrosis	perivascular fibrosis	perivascular fibrosis	1.88E-02	 	0.000	 	-0.248	ETS1,HMOX1,PLA2G2A,AGT	4	
Renal Proliferation	proliferation	proliferation of glomerular cells	1.90E-02	 	0.164	 	-0.394	APOE,SRC,PLAUR,MST1,IL6,AXL,SLK,EDN1,DUSP1,FCER1G,SPARC,ITGA1,AKR1B1,AGT	14	
Liver Hyperplasia/Hyperproliferation	growth	growth of liver tumor	1.94E-02	 	0.360	 	-0.406	SOCS3,LEP,CXCR4,TNFSF10,IL6,GPC3,AKR1B10,ODC1,MYC,PEG10,RGN,NOTCH1,mir-21	13	
Cardiac Congestive Cardiac Failure, Heart Failure	congestive heart failure	congestive heart failure	1.94E-02	 	-1.123	bias	0.689	ADM,AOC3,MYCN,CDK4,ADIPOQ,FKBP1A,IL6,ATP2A2,GSS,IGF2R,IDUA,ZFPM2,ADRA2A,NPR3,PDE3B,CAV1,STAB1,SOX9,HEY2,BIRC3,ADRA1A,PTGER4,ADRA1B,ADRB2	24	
Renal Damage	damage	damage of nephron	2.07E-02	 	1.334	 	1.016	ADM,CCR1,BMP4,FGF2,CAT,MST1,AGT,CYP2C8	8	
Cardiac Dysfunction	dysfunction	dysfunction of left ventricle	2.07E-02	 	0.128	 	0.180	TGFBR2,CSF3R,PTX3,ANGPTL4,TIMP1,CAST,MAP2K5,MMP9	8	
Liver Hyperplasia/Hyperproliferation	cancer	cancer of liver cells	2.09E-02	 	 	 	 	TGFBR2,TIMP1	2	
Cardiac Hypoplasia	hypoplasia	hypoplasia of ventricular myocardium	2.09E-02	 	 	 	 	ZFPM2,ADRBK1	2	
Increased Levels of Albumin	flux	increased flux of albumin	2.09E-02	 	 	 	 	THBS1,KDR	2	
Liver Failure	infantile liver failure syndrome type 2	infantile liver failure syndrome type 2	2.09E-02	 	 	 	 	NBAS,MARS	2	
Cardiac Damage, Cardiac Degeneration	injury	injury of ventricular myocytes	2.09E-02	 	 	 	 	mir-21,PDCD4	2	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells/myofibroblasts	2.09E-02	 	 	 	 	CTSB,SMPD1	2	
Cardiac Hypertrophy	hypertrophy	hypertrophy of left ventricle	2.19E-02	 	0.514	bias	1.699	RNLS,LEP,FKBP1A,TPM1,HMGA1,IER3,ATP2A2,RCAN1,MTOR,PBX3,ADRA2A,GAA,VAV3,CAV1,MAPK7,CASQ2,ADRA1A,ADRB2,PLAT,AGT	20	
Heart Failure	chronic heart failure	chronic heart failure	2.31E-02	 	 	 	 	CSF3R,CA3,ADRA2A,TF,CA4,CA5B,CA12,ADRA1A,ADRA1B,ADRB2	10	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatic stellate cells	2.39E-02	 	-0.441	 	-0.698	TIMP1,SERPINH1,ADIPOQ,TNFSF10,HBEGF,NGF,MMP9	7	
Glomerular Injury, Renal Damage	injury	injury of renal glomerulus	2.39E-02	 	1.054	 	0.699	ADM,CCR1,BMP4,FGF2,MST1,AGT,CYP2C8	7	
Cardiac Damage, Cardiac Degeneration	injury	injury of cardiomyocytes	2.41E-02	 	 	 	 	TXN,mir-21,PDCD4	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	hepatocellular carcinoma	2.63E-02	 	0.894	 	1.304	CBX7,APOB,AXIN1,WBSCR22,HRAS,GHITM,IL6,POR,CLCNKA,CSE1L,SPAG8,RARA,KEAP1,TXN,CDKN1C,MMP2,IFNAR2,WDR81,BSG,PPP1R15A,RTN4,CCDC178,NOTCH1,mir-21,AKAP12,SPTBN1,SQLE,NME1,ADAM17,RALA,CHCHD10,FGF2,CDK4,TNFSF10,FKBP1A,VCAN,IDH1,SPON1,MTOR,JUN,CD24,RASSF5,ASPH,MORN4,STK19,CD276,MGMT,MED30,SLIT2,AXL,IGF2R,POLD1,GABRE,PAMR1,GLG1,HP,KRT8,ZFPM2,SLC22A18,SOX9,CBX4,PTGS2,NENF,SYN2,MVD,MT2A,FOXRED1,SOCS3,CYTOR,PFN1,TYMP,ZNF91,HSPA5,GPC3,BIN1,MYC,TGFBR2,PADI4,NNMT,CTSD,TNIP1,IKBKG,AMPH,NUPR1,STAB1,LTBR,RET,TEK,PDK4,CXCL8,MGRN1,AXIN2,SPP1,ADAMTS1,H6PD,THRA,AKR1B10,TXNRD1,LMCD1,FCN3,BCL2L1,EXOSC4,IGFBP3,RGN,AGAP3,ESR1,CCDC80,ARL2,ERAP2,LEP,SLC1A4,PKM,ABL1,PPIP5K1,HIF1A,ALDH2,ENPP4,C7,SMO,KIT,ENPP2,ERBB2,SULF2,MCRS1,NCL,CUL9,ATP13A2,AGT,NUSAP1,NQO1,AP3B2,PLAUR,BSCL2,PSME3,CSF1R,FAIM,ADGRG1,LPAR1,ING1,KDR,MMP9	141	
Nephrosis	minimal change nephrotic syndrome	minimal change nephrotic syndrome	2.70E-02	 	 	 	 	GSTM1,MTOR,IMPDH2,CST3,FKBP1A,GSTT1	6	
Cardiac Arrythmia	atrial fibrillation	atrial fibrillation	2.80E-02	 	 	 	 	KCNJ2,KCNK3,IL6,ATP2A2,CCL2,KCNMA1,TIMP1,TUBA1C,ABCC9,ADRA1B,ADRB2,PLAT,VCAM1,NUP155,TUBG1,TUBB2A,DGAT2,THRA,VKORC1,ADRA2A,ATP1A2,PTGS2,ADRA1A,MMP9,MAOA,COL3A1	26	
Increased Levels of Hematocrit	hematocrit	increased hematocrit of organism	2.89E-02	 	 	 	 	LIG1,FERMT3,APOE,RBM38,CD59,EPAS1,SPP1,FRZB,SPI1,APRT,NFE2L1,CIAPIN1,TGM2,HMOX1,TNIP1,LGMN,EPB42,ATF4,BNIP3L,PTGS2,ZFP36L2	21	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney	2.93E-02	 	-0.452	bias	0.757	PTGIS,SPP1,SGCG,MTSS1,SMAD7,ADIPOQ,MMP2,APRT,STC1,XYLT2,MAN2C1,LGMN,PKD1,CCL2,VAV3,STAB1,PTGS2,mir-21,AGT	19	
Renal Necrosis/Cell Death	cell death	cell death of proximal tubule cells	2.96E-02	 	-0.200	 	0.164	CAT,AQP11,HIF1A,ADORA1,AGT	5	
Cardiac Stenosis	non-rheumatic aortic stenosis	non-rheumatic aortic stenosis	3.00E-02	 	 	 	 	VCAM1,SELE,MMP2,MMP9	4	
Liver Cholestasis	secretion	secretion of bile acid	3.00E-02	 	1.067	 	0.871	HMOX1,CES1,CYP27A1,ESR1	4	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of renal glomerulus	3.00E-02	 	-1.982	bias	-1.218	APOE,CFB,C1QA,C2	4	
Increased Levels of Red Blood Cells	quantity	increased quantity of red blood cells	3.01E-02	 	 	 	 	EIF2AK1,CD59,EPAS1,BMP4,DNASE2,SIN3B,MAF,CDK4,SLC7A1,CIAPIN1,TGM2,HMOX1,ID1,CCND2,LGMN,CCND3,EPB42,BNIP3L,ZFP36L2,ARID4A,APEX2,STX11	22	
Liver Fibrosis	migration	migration of hepatic stellate cells	3.08E-02	 	-0.860	bias	-1.892	MIF,CTGF,SPP1,EDN1,CCL2,CCL3,AGT	7	
Liver Fibrosis	activation	activation of hepatic stellate cells	3.21E-02	 	-0.288	bias	-1.379	PLA2G4A,MIF,LEP,EDN1,TIMP1,LEPR,FGF2,CXCL12,BAMBI,IL6,MMP9,AGT	12	
Renal Inflammation, Renal Nephritis	autoimmune glomerulonephritis	autoimmune glomerulonephritis	3.25E-02	 	 	 	 	SELE,PSMB5,DDIT3,IMPDH2,DGAT2,FKBP1A,HBEGF,IL6,ASNS,JUN,GADD45A,PSMB2,BMF,IDO1,AGT	15	
Liver Hyperplasia/Hyperproliferation	proliferation	proliferation of liver cancer cells	3.27E-02	 	1.219	 	0.787	SOCS3,LEP,PEG10,RGN,GPC3,NOTCH1,ODC1,mir-21	8	
Cardiac Damage	damage	damage of heart	3.30E-02	 	-0.273	 	0.522	PPP1R1A,GDF15,ADIPOQ,SLC9A1,PDCD4,ALDH2,HMOX1,CAV1,ATF4,MAP2K3,TXN,ADORA1,SGCD,MMP9,mir-21,HADHA,AGT	17	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart ventricle	3.35E-02	 	1.416	 	1.468	S100A1,PRKCD,CAT,ADIPOQ,RTN4,MMP2,GSK3B,ADRA1A,mir-21	9	
Nephrosis	familial nephrotic syndrome	familial nephrotic syndrome	3.57E-02	 	 	 	 	ITGA3,ADCK4,PLCE1,IMPDH2,ARHGDIA,ITGA1	6	
Renal Hydronephrosis	hydronephrosis	hydronephrosis	3.81E-02	 	-0.931	bias	0.492	CXCL8,LEP,SFRP2,BMP4,ADAMTS1,PLAUR,MYH11,GPC3,APRT,XYLT2,LGMN,CCL2,RARA,SMO,ALCAM,IMPA2,ADRA1A,ADRA1B,MMP9,AGT	20	
Cardiac Arrythmia	arrhythmia	arrhythmia	3.86E-02	 	1.159	 	1.353	PTGFR,KCNK3,KCNJ2,SNTA1,HRAS,TPM1,IL6,ATP2A2,TGM2,CCL2,TIMP1,KCNMA1,ANK2,TUBA1C,TXN,HEY2,ASPH,ABCC9,ADORA1,PI4KA,CASQ2,ADRA1B,PLAT,AGT,ADRB2,SLC2A5,KCNJ8,VCAM1,NUP155,PKP2,TUBG1,TUBB2A,DGAT2,LMNA,MMP2,THRA,ADRA2A,VKORC1,ATP1A2,PTGS2,DSG2,P2RX7,MMP9,ADRA1A,COL3A1,MAOA	46	
Liver Inflammation/Hepatitis, Liver Steatosis	steatohepatitis	steatohepatitis	3.87E-02	 	0.000	bias	0.929	IKBKG,LEP,APOB,LPIN1,PDE3B,ADIPOQ,CD14,IL6,ADORA1,ADIPOR2,NFE2L1	11	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of mesangial cells	3.89E-02	 	0.563	 	0.446	APOE,GFPT1,NFKBIA,CTGF,ATF3,DUSP1,PTGS2	7	
Liver Inflammation/Hepatitis	alcoholic hepatitis	alcoholic hepatitis	4.03E-02	 	 	 	 	CSF3R,CXCL8,CCL2,PDE3B,THOP1,IL6,CXCL2,ADORA1,COL3A1	9	
Kidney Failure, Liver Failure	hepatorenal syndrome	hepatorenal syndrome	4.06E-02	 	 	 	 	EDN1,ADRA2A,ADRA1A,ADRA1B,ADRB2	5	
Increased Levels of Creatinine	clearance	increased clearance of creatinine	4.06E-02	 	 	 	 	ADM,VAV3,ARHGDIA,APRT,AGT	5	
Liver Adhesion	adhesion	adhesion of hepatocytes	4.30E-02	 	 	 	 	VCAM1,KRT8,ITGAM	3	
Renal Proliferation	growth	arrest in growth of kidney cell lines	4.30E-02	 	 	 	 	FOS,HRAS,LMNA	3	
Renal Dilation	dilation	dilation of collecting tubule	4.30E-02	 	 	 	 	PKD1,ARHGDIA,PRKCSH	3	
Cardiac Enlargement	enlargement	enlargement of heart ventricle	4.30E-02	 	 	 	 	NLRP3,ADORA1,P2RX7	3	
Liver Fibrosis	experimentally-induced hepatic fibrosis	experimentally-induced hepatic fibrosis	4.30E-02	 	 	 	 	TGFBR2,SPP1,mir-21	3	
Liver Cholestasis	obstructive cholestasis	obstructive cholestasis	4.30E-02	 	 	 	 	CD68,ABCC3,GJB2	3	
Renal Transformation	transformation	transformation of kidney cells	4.30E-02	 	 	 	 	SRC,HRAS,NOTCH1	3	
Renal Necrosis/Cell Death	apoptosis	apoptosis of proximal tubule cells	4.44E-02	 	-0.655	 	-0.546	AQP11,HIF1A,ADORA1,AGT	4	
Cardiac Output	cardiac output	cardiac output of heart	4.44E-02	 	 	 	 	CD36,HRAS,ADRA1A,ADRA1B	4	
Cardiac Damage	cardiovascular toxicity	cardiovascular toxicity	4.44E-02	 	 	 	 	CYBA,ABCC1,CAT,ERBB2	4	
Cardiac Enlargement	enlargement	enlargement of heart chamber	4.44E-02	 	1.067	bias	0.521	NLRP3,GSK3B,ADORA1,P2RX7	4	
Renal Proliferation	proliferation	proliferation of mesangial cells	4.51E-02	 	-0.572	 	-1.205	APOE,EDN1,FCER1G,SPARC,PLAUR,MST1,ITGA1,IL6,AKR1B1,AXL,AGT	11	
Liver Cirrhosis	cirrhosis	cirrhosis of liver	4.55E-02	 	 	 	 	CTGF,LEP,APOB,SLC4A2,FRZB,TNFSF10,IL6,HNRNPK,CCL8,CCL2,CSF2RA,ABCC1,GCLM,ALPL,ADRA1B,ADRB2,CXCL8,C5AR1,SPP1,FST,CXCR4,NQO1,MMP2,MNDA,IFNAR2,GLG1,KRT8,LDLR,VKORC1,BSG,CD86,ABCC3,NOTCH1,MMP9,ADRA1A,COL3A1	36	
Congenital Heart Anomaly	transposition	transposition of great vessels	4.60E-02	 	0.557	bias	1.754	DVL2,TGFBR3,SMAD7,EDNRA,DVL3,NRP1	6	
Congenital Heart Anomaly	conotruncal heart malformations	conotruncal heart malformations	4.65E-02	 	0.201	bias	1.724	DHRS3,CFC1/CFC1B,TGFBR3,SMAD7,GPC3,DVL2,ZFPM2,JUN,EDN1,PKD1,FLNA,RARA,MKL2,EDNRA,DVL3,HEY2,NRP1	17	
Renal Proliferation	proliferation	proliferation of kidney cells	4.65E-02	 	-0.390	 	-0.753	SRC,APOE,AQP11,MST1,PLAUR,IL6,AXL,SLK,EDN1,GADD45A,PKD1,DUSP1,FCER1G,SPARC,ITGA1,AKR1B1,AGT	17	
Cardiac Necrosis/Cell Death	cell death	cell death of heart ventricle	4.68E-02	 	1.553	 	1.639	S100A1,PRKCD,CAT,ADIPOQ,RTN4,MMP2,GSK3B,ADRA1A,mir-21,AGT	10	
Cardiac Dilation	dilation	dilation of heart chamber	4.70E-02	 	0.180	 	0.518	TGFBR2,CAMK2D,CAPNS1,PLCE1,SPP1,TIMP1,CAV1,NUPR1,HBEGF,LMNA,CAST,MMP9,ADRB2	13	
Renal Necrosis/Cell Death	cell death	cell death of renal tubule	5.30E-02	 	-1.221	 	-0.630	NLRP3,SPP1,AQP11,UNC5B,LRRK2,MST1,HIF1A,APRT,HMOX1,THBS1,CAT,IDO1,ADORA1,mir-21,AGT	15	
Liver Damage	damage	damage of liver	5.38E-02	 	0.479	 	0.463	HAVCR2,IL6,SDC4,TGFBR2,POR,GAA,KEAP1,STAB1,LTBR,CXCL8,MIF,SPP1,TNFRSF10B,PAWR,THOP1,IFNAR2,BCL2L1,PPOX,BSG,DUSP1,CTSB,CD14,RGN,MAP2K3,COL3A1,ADM,APOE,LEP,DDIT3,ADIPOQ,TNFAIP3,FKBP1A,TNFSF10,SMPD1,ALDH2,HMOX1,MTOR,HLA-DRB1,JUN,EDN1,CCL2,TIMP1,STUB1,SAA1,LBP,IL11RA,FAAH,NLRP3,IMPDH2,EGR1,SAA2,POLD1,KRT8,PTGS2,DNM1L,P2RX7,MMP9	57	
Cardiac Damage, Cardiac Degeneration	degeneration	degeneration of cardiomyocytes	5.39E-02	 	-0.447	bias	0.218	CAV1,TXN,HADHA,mir-21,PDCD4	5	
Increased Levels of AST	localization	increased localization of AST	5.39E-02	 	 	 	 	APOE,ATF3,SAA1,MAP3K8,PTGS2	5	
Cardiac Output	cardiac output	cardiac output	5.46E-02	 	0.137	bias	-0.736	IDUA,ELN,APOE,CD36,CDK4,HRAS,ATP2A2,ADRA1A,ADRA1B,MMP9	10	
Cardiac Arrythmia	arrhythmia	arrhythmia of heart ventricle	5.62E-02	 	1.117	bias	1.754	KCNJ8,KCNK3,KCNJ2,PKP2,SNTA1,LMNA,TPM1,THRA,TGM2,ADRA2A,ANK2,ASPH,ABCC9,DSG2,P2RX7,CASQ2,ADRA1B,ADRA1A,ADRB2,MAOA	20	
Cardiac Dilation	dilation	dilation of heart ventricle	5.66E-02	 	0.466	 	0.748	TGFBR2,CAMK2D,CAPNS1,PLCE1,SPP1,TIMP1,CAV1,HBEGF,LMNA,CAST,MMP9,ADRB2	12	
Liver Steatosis	hepatic steatosis	advanced stage hepatic steatosis	5.67E-02	 	 	 	 	LEP,SPP1	2	
Heart Failure	cardiomyopathic heart failure	cardiomyopathic heart failure	5.67E-02	 	 	 	 	ATP2A2,ADRB2	2	
Cardiac Necrosis/Cell Death	cell death	cell death of left ventricle	5.67E-02	 	 	 	 	GSK3B,AGT	2	
Renal Degeneration	degeneration	degeneration of renal tubule	5.67E-02	 	 	 	 	ARHGDIA,MDK	2	
Cardiac Enlargement	enlargement	enlargement of left ventricle	5.67E-02	 	 	 	 	NLRP3,P2RX7	2	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of renal tubule	5.67E-02	 	 	 	 	LGMN,HSD11B2	2	
Glomerular Injury, Renal Hypoplasia	hypoplasia	hypoplasia of mesangial cells	5.67E-02	 	 	 	 	GPR4,ARHGDIA	2	
Cardiac Stress Response	oxidative stress response	oxidative stress response of myocardium	5.67E-02	 	 	 	 	TXN,AGT	2	
Cardiac Fibrosis	perivascular fibrosis	perivascular fibrosis of artery	5.67E-02	 	 	 	 	ETS1,AGT	2	
Glutathione Depletion In Liver	conjugation	conjugation of glutathione	5.79E-02	 	-0.085	bias	-1.295	GSTM1,MIF,GSTM2,GSTM5,GSTT1,CYP1B1	6	
Increased Levels of ALT	localization	increased localization of ALT	5.79E-02	 	 	 	 	APOE,SAA1,TNFSF10,SMPD1,C1QA,IL6	6	
Congenital Heart Anomaly	perimembranous ventricular septal defect	perimembranous ventricular septal defect	5.89E-02	 	1.054	bias	2.346	CXCR4,RARA,CXCL12,MKL2,EDNRA,HEY2,GPC3	7	
Renal Atrophy	atrophy of kidney	atrophy of kidney	5.99E-02	 	0.357	bias	1.591	PTGIS,BMP4,LGMN,ADAMTS1,EDNRA,LRRK2,MMP2,PTGS2,GPC3,APRT,AGT	11	
Liver Proliferation	proliferation	proliferation of hepatocytes	6.02E-02	 	0.420	 	-0.239	SPTBN1,SOCS3,BMP4,CXCL12,HRAS,MST1,IL6,GPC3,ODC1,TNFRSF12A,MYC,TGFBR2,NFKBIA,JUN,CCND3,THBS1,TIMP1,RARA,SMARCB1,CXCL14,CAV1,SLC7A5,GSK3B,SULF2,AGT,SLC20A1,CXCR4,SMAD7,TOB1,FOS,ERCC1,mir-21	32	
Cardiac Damage	injury	injury of heart	6.32E-02	 	-0.122	 	0.336	ALDH2,PPP1R1A,ADIPOQ,ATF4,MAP2K3,TXN,ADORA1,mir-21,PDCD4,AGT	10	
Cardiac Arrythmia	ventricular fibrillation	ventricular fibrillation	6.32E-02	 	 	 	 	TGM2,KCNJ8,KCNK3,PKP2,KCNJ2,SNTA1,LMNA,THRA,P2RX7,ADRB2	10	
Cardiac Arrythmia, Tachycardia	ventricular tachycardia	ventricular tachycardia	6.61E-02	 	 	 	 	KCNJ2,KCNK3,LMNA,TPM1,THRA,ADRA2A,ANK2,ASPH,ABCC9,DSG2,ADRA1B,ADRA1A,CASQ2,ADRB2,MAOA	15	
Renal Hypertrophy	hypertrophy	hypertrophy of renal tubule	6.73E-02	 	 	 	 	HSD11B2,PTGS2,AGT	3	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of ventricular myocytes	6.90E-02	 	1.129	 	1.228	S100A1,PRKCD,CAT,ADIPOQ,RTN4,MMP2,ADRA1A,mir-21	8	
Liver Hemorrhaging	bleeding	bleeding of liver	6.90E-02	 	-0.707	bias	0.514	ADM,IKBKG,KRT8,MKL2,FKBP1A,PTGS2,RAMP2,FAIM	8	
Cardiac Arrythmia, Tachycardia	tachycardia	tachycardia	7.24E-02	 	1.165	 	1.489	PTGFR,KCNK3,KCNJ2,LMNA,TPM1,THRA,ADRA2A,ATP1A2,ANK2,ASPH,ADORA1,ABCC9,DSG2,CASQ2,ADRA1B,ADRA1A,ADRB2,AGT,MAOA	19	
Cardiac Arrythmia	supraventricular arrhythmia	supraventricular arrhythmia	7.49E-02	 	 	 	 	KCNJ2,KCNK3,IL6,ATP2A2,CCL2,KCNMA1,TIMP1,TUBA1C,ADORA1,ABCC9,ADRA1B,ADRB2,PLAT,VCAM1,NUP155,TUBG1,TUBB2A,DGAT2,THRA,VKORC1,ADRA2A,ATP1A2,PTGS2,ADRA1A,MMP9,MAOA,COL3A1	27	
Congenital Heart Anomaly	familial congenital heart disease	familial congenital heart disease	8.06E-02	 	0.638	bias	2.305	DHRS3,TGFBR3,CFC1/CFC1B,SMAD7,NAA10,GPC3,COL1A2,DVL2,SH3PXD2B,ZFPM2,JUN,PLCE1,EDN1,PKD1,FLNA,RARA,MKL2,EDNRA,DVL3,B3GAT3,HEY2,NRP1	22	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 1	catecholaminergic polymorphic ventricular tachycardia type 1	8.26E-02	 	 	 	 	ANK2,LMNA,TPM1,DSG2	4	
Glomerular Injury	cortical renal glomerulopathies	cortical renal glomerulopathies	8.26E-02	 	1.000	bias	1.992	FYN,CDKN2C,PTGS2,ESR1	4	
Cardiac Infarction	infarction	infarction of heart	8.26E-02	 	 	 	 	BCL2L1,CAV1,PRKCE,THBD	4	
Cardiac Proliferation	proliferation	proliferation of ventricular myocytes	8.26E-02	 	-1.016	bias	-1.837	PLCE1,LEP,EDN1,AGT	4	
Cardiac Arrythmia	tachyarrhythmia	tachyarrhythmia	8.26E-02	 	 	 	 	ADRA2A,ADRA1A,ADRA1B,ADRB2	4	
Renal Necrosis/Cell Death	cell viability	cell viability of kidney cell lines	8.28E-02	 	1.041	 	0.428	DPYD,FGF2,HYOU1,CEBPD,TNFAIP3,HBEGF,SGPL1,NFKBIA,ANXA5,CAV1,RPS6KB2,PRKCE,MAP3K8,RET,ABCC3,P2RX7	16	
Renal Necrosis/Cell Death	necrosis	necrosis of renal tubule	8.49E-02	 	-1.234	 	-0.628	HMOX1,SPP1,NLRP3,AQP11,UNC5B,CAT,MST1,IDO1,HIF1A,ADORA1,APRT,mir-21,AGT	13	
Renal Degeneration	degeneration	degeneration of kidney	8.68E-02	 	0.128	 	0.731	MTSS1,ARHGDIA,PTGS2,SDC4,MDK,TNS1	6	
Glomerular Injury	formation	formation of glomerular crescent	8.68E-02	 	-0.391	bias	0.245	CCR1,STC1,HMOX1,MIF,C1QA,PLAT	6	
Congenital Heart Anomaly	double outlet right ventricle	double outlet right ventricle	8.77E-02	 	 	 	 	DVL2,DHRS3,ZFPM2,EDN1,PKD1,RARA,CFC1/CFC1B,MKL2,EDNRA,DVL3,GPC3	11	
Liver Necrosis/Cell Death	cell death	cell death of liver cell lines	8.83E-02	 	-1.348	 	-1.675	MYC,BCL2L1,LAMP2,GADD45B,JUN,TIMP1,TNFSF10,PTGS2,IER3	9	
Cardiac Necrosis/Cell Death	necrosis	necrosis of heart ventricle	8.83E-02	 	1.291	 	1.415	S100A1,PRKCD,CAT,ADIPOQ,RTN4,MMP2,ADRA1A,mir-21,AGT	9	
Renal Inflammation, Renal Nephritis	nephrotoxic nephritis	nephrotoxic nephritis	9.63E-02	 	 	 	 	LEP,IDO1,FCGR3A/FCGR3B	3	
Congenital Heart Anomaly	atresia	atresia of tricuspid valve	1.03E-01	 	 	 	 	ZFPM2,HEY2	2	
Cardiac Necrosis/Cell Death	cell death	cell death of cardiac stem cells	1.03E-01	 	 	 	 	SFRP2,PIN1	2	
Liver Necrosis/Cell Death	cell death	cell death of sinusoidal endothelial cells	1.03E-01	 	 	 	 	TNFSF10,IL6	2	
Cardiac Arteriopathy	coronary occlusion	coronary occlusion	1.03E-01	 	 	 	 	APOE,SGCD	2	
Liver Dysfunction	dysfunction	dysfunction of liver	1.03E-01	 	 	 	 	ATF3,ATF6	2	
Liver Hyperplasia/Hyperproliferation	liver cancer	early stage liver cancer	1.03E-01	 	 	 	 	FOS,JUN	2	
Increased Levels of Red Blood Cells	production	increased production of red blood cells	1.03E-01	 	 	 	 	EPAS1,ARID4A	2	
Liver Damage	injury	injury of hepatocytes	1.03E-01	 	 	 	 	FAAH,EGR1	2	
Liver Cholestasis	lipopolysaccharide hepatocellular cholestasis	lipopolysaccharide hepatocellular cholestasis	1.03E-01	 	 	 	 	CD68,GJB2	2	
Liver Steatosis	microvesicular hepatic steatosis	microvesicular hepatic steatosis	1.03E-01	 	 	 	 	UPP1,SLC22A5	2	
Kidney Failure	nephrotoxic acute renal failure	nephrotoxic acute renal failure	1.03E-01	 	 	 	 	HMOX1,ATF3	2	
Renal Proliferation	proliferation	proliferation of proximal tubule cells	1.03E-01	 	 	 	 	AQP11,AGT	2	
Renal Dilation	vasodilation	vasodilation of kidney	1.03E-01	 	 	 	 	ADM,AGT	2	
Renal Dilation	dilation	dilation of renal tubule	1.06E-01	 	-1.980	bias	-1.326	PKD1,ARHGDIA,APRT,PRKCSH	4	
Cardiac Hypoplasia	hypoplasia	hypoplasia of myocardium	1.06E-01	 	-1.982	bias	-1.000	MYCN,ZFPM2,ADRBK1,GNA11	4	
Cardiac Dysfunction	dysfunction	dysfunction of heart	1.08E-01	 	-0.108	 	0.041	PTX3,CSF3R,APOE,NOX4,LEP,ATF3,GRB14,CD36,TGFBR2,ALDH2,ANGPTL4,TIMP1,CAST,MMP9,mir-21,MAP2K5	16	
Renal Damage, Renal Tubule Injury	damage	damage of renal tubule	1.19E-01	 	1.000	 	0.730	CCR1,APOE,EDN1,THBS1,LEPR,CAT,CFB,HBEGF,PLAUR,MDK	10	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubule	1.22E-01	 	-1.235	 	-0.847	HMOX1,NLRP3,THBS1,UNC5B,AQP11,MST1,LRRK2,HIF1A,ADORA1,mir-21,AGT	11	
Liver Damage	injury	injury of liver	1.23E-01	 	-0.069	 	0.031	ADM,APOE,LEP,DDIT3,ADIPOQ,FKBP1A,IL6,SDC4,TGFBR2,POR,HMOX1,ALDH2,MTOR,HLA-DRB1,EDN1,CCL2,STUB1,TIMP1,GAA,SAA1,STAB1,LTBR,IL11RA,FAAH,CXCL8,NLRP3,SPP1,IMPDH2,EGR1,TNFRSF10B,THOP1,SAA2,IFNAR2,POLD1,BCL2L1,KRT8,BSG,CTSB,RGN,CD14,MAP2K3,DNM1L,P2RX7,MMP9,COL3A1	45	
Increased Levels of Alkaline Phosphatase	activation	increased activation of alkaline phosphatase	1.27E-01	 	 	 	 	LEP,BMP4,CTGF,BMP2,PLAUR,IL6,WDR5,MN1,LDLR,BMP6,TNFRSF19,NOTCH1,ESR1,PTGER4	14	
Liver Inflammation/Hepatitis	acute hepatitis	acute hepatitis	1.29E-01	 	 	 	 	NAGLU,MMP2,IFNAR2,MMP9,COL3A1	5	
Heart Failure	cardiac death	cardiac death	1.30E-01	 	 	 	 	ANK2,GRK5,DSG2	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	size	size of hepatocellular carcinoma	1.30E-01	 	 	 	 	TGFBR2,JUN,LEP	3	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney component	1.32E-01	 	-0.849	bias	0.133	MAN2C1,STAB1,PTGS2,APRT	4	
Liver Cholestasis	cholestasis	cholestasis	1.36E-01	 	 	 	 	ABCB6,CXCL8,SLC25A13,TJP2,CYP27A1,AKR1C3,SLC12A2,ADH1C,TNFSF10,ABCG1,IL6,SLC35B1,IKBKG,SLC25A6,CD68,ABCC1,LBP,ABCC3,GJB2	19	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	nonalcoholic steatohepatitis	1.42E-01	 	 	 	 	LEP,APOB,PDE3B,ADIPOQ,ADORA1,ADIPOR2	6	
Pulmonary Hypertension	Dursun syndrome	Dursun syndrome	1.45E-01	 	 	 	 	G6PC3	1	
Congenital Heart Anomaly	Frank-Ter Haar syndrome	Frank-Ter Haar syndrome	1.45E-01	 	 	 	 	SH3PXD2B	1	
Cardiac Stenosis	Keutel syndrome	Keutel syndrome	1.45E-01	 	 	 	 	MGP	1	
Congenital Heart Anomaly	Ogden syndrome	Ogden syndrome	1.45E-01	 	 	 	 	NAA10	1	
Renal Inflammation, Renal Nephritis	X-linked Alport's syndrome	X-linked Alport's syndrome	1.45E-01	 	 	 	 	COL4A5	1	
Hepatocellular Peroxisome Proliferation	activation	activation of PPARA in liver cells	1.45E-01	 	 	 	 	PLIN2	1	
Kidney Failure	renal failure	advanced renal failure	1.45E-01	 	 	 	 	AQP11	1	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	advanced stage nonalcoholic steatohepatitis	1.45E-01	 	 	 	 	LEP	1	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of adventitial fibroblasts	1.45E-01	 	 	 	 	mir-21	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatoblasts	1.45E-01	 	 	 	 	JUN	1	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of left ventricle	1.45E-01	 	 	 	 	GSK3B	1	
Cardiac Arrythmia	arrhythmogenic right ventricular dysplasia familial 10	arrhythmogenic right ventricular dysplasia familial 10	1.45E-01	 	 	 	 	DSG2	1	
Cardiac Arrythmia	arrhythmogenic right ventricular dysplasia familial 9	arrhythmogenic right ventricular dysplasia familial 9	1.45E-01	 	 	 	 	PKP2	1	
Renal Inflammation, Renal Nephritis	atypical nephropathic cystinosis	atypical nephropathic cystinosis	1.45E-01	 	 	 	 	CTNS	1	
Liver Fibrosis	biliary fibrosis	biliary fibrosis	1.45E-01	 	 	 	 	IL6	1	
Liver Hemorrhaging	bleeding	bleeding of liver parenchyma	1.45E-01	 	 	 	 	PTGS2	1	
Liver Hyperplasia/Hyperproliferation	cancer	cancer of hepatocytes	1.45E-01	 	 	 	 	TIMP1	1	
Congenital Heart Anomaly	cardiac valvular form autosomal recessive Ehlers-Danlos syndrome	cardiac valvular form autosomal recessive Ehlers-Danlos syndrome	1.45E-01	 	 	 	 	COL1A2	1	
Cardiac Damage	cardiovascular toxicity property	cardiovascular toxicity property of trastuzumab	1.45E-01	 	 	 	 	ERBB2	1	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 2	catecholaminergic polymorphic ventricular tachycardia type 2	1.45E-01	 	 	 	 	CASQ2	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic persistent hepatitis	chronic persistent hepatitis	1.45E-01	 	 	 	 	THOP1	1	
Nephrosis	congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa	congenital interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa	1.45E-01	 	 	 	 	ITGA3	1	
Renal Lysis	cytolysis	cytolysis of mesangial cells	1.45E-01	 	 	 	 	THY1	1	
Decreased Levels of Albumin	accumulation	decreased accumulation of albumin	1.45E-01	 	 	 	 	CAV1	1	
Renal Degeneration	degeneration	degeneration of renal tubular epithelial cells	1.45E-01	 	 	 	 	ARHGDIA	1	
Kidney Failure	renal failure	delay in renal failure	1.45E-01	 	 	 	 	CFB	1	
Glomerular Injury, Renal Destruction	destruction	destruction of glomerular capillary	1.45E-01	 	 	 	 	THY1	1	
Cardiac Arteriopathy	development of coronary artery disease in HIV	development of coronary artery disease in HIV	1.45E-01	 	 	 	 	CCL2	1	
Heart Failure	dilated cardiomyopathic failure	dilated cardiomyopathic failure	1.45E-01	 	 	 	 	ATP2A2	1	
Cardiac Arrythmia, Tachycardia	dilated cardiomyopathy 1o	dilated cardiomyopathy 1o	1.45E-01	 	 	 	 	ABCC9	1	
Cardiac Dysfunction	dysfunction	dysfunction of myocardium	1.45E-01	 	 	 	 	LEP	1	
Cardiac Congestive Cardiac Failure, Heart Failure	congestive heart failure	end-stage congestive heart failure	1.45E-01	 	 	 	 	ADM	1	
Cardiac Enlargement	enlargement	enlargement of cardiac valve	1.45E-01	 	 	 	 	HBEGF	1	
Glomerular Injury	experimental glomerular disease	experimental glomerular disease	1.45E-01	 	 	 	 	CDKN1C	1	
Liver Inflammation/Hepatitis, Liver Steatosis	experimental nonalcoholic steatohepatitis	experimental nonalcoholic steatohepatitis	1.45E-01	 	 	 	 	ADIPOQ	1	
Heart Failure	experimentally-induced heart failure	experimentally-induced heart failure	1.45E-01	 	 	 	 	PTGS2	1	
Cardiac Arrythmia	familial atrial fibrillation type 12	familial atrial fibrillation type 12	1.45E-01	 	 	 	 	ABCC9	1	
Cardiac Arrythmia	familial atrial fibrillation type 9	familial atrial fibrillation type 9	1.45E-01	 	 	 	 	KCNJ2	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	fibrolamellar carcinoma	fibrolamellar carcinoma	1.45E-01	 	 	 	 	MTOR	1	
Liver Fibrosis	fibrosis	fibrosis of portal tract	1.45E-01	 	 	 	 	XYLT2	1	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of distal convoluted tubule	1.45E-01	 	 	 	 	HSD11B2	1	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of proximal tubule cells	1.45E-01	 	 	 	 	LGMN	1	
Pulmonary Hypertension	hypertension	hypertension of pulmonary artery	1.45E-01	 	 	 	 	CAV1	1	
Glomerular Injury	hypertension	hypertension of renal glomerulus	1.45E-01	 	 	 	 	AGT	1	
Renal Hypertrophy	hypertrophy	hypertrophy of distal convoluted tubule	1.45E-01	 	 	 	 	HSD11B2	1	
Kidney Failure, Pulmonary Hypertension	hyperuricemia, pulmonary hypertension, renal failure, and alkalosis	hyperuricemia, pulmonary hypertension, renal failure, and alkalosis	1.45E-01	 	 	 	 	SARS2	1	
Cardiac Hypoplasia	hypoplasia	hypoplasia of ventricular compact zone	1.45E-01	 	 	 	 	ZFPM2	1	
Increased Levels of Albumin	export	increased export of albumin	1.45E-01	 	 	 	 	RAN	1	
Liver Cirrhosis	indian childhood cirrhosis	indian childhood cirrhosis	1.45E-01	 	 	 	 	UTP4	1	
Liver Failure	infantile liver failure syndrome type 1	infantile liver failure syndrome type 1	1.45E-01	 	 	 	 	LARS	1	
Renal Inflammation, Renal Nephritis	inflammation	inflammation of renal tubule	1.45E-01	 	 	 	 	APRT	1	
Renal Damage, Renal Tubule Injury	injury	injury of proximal tubule cells	1.45E-01	 	 	 	 	CAT	1	
Heart Failure	ischemic cardiomyopathic heart failure	ischemic cardiomyopathic heart failure	1.45E-01	 	 	 	 	ATP2A2	1	
Glomerular Injury	lipoprotein glomerulopathy	lipoprotein glomerulopathy	1.45E-01	 	 	 	 	APOE	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 12	long QT syndrome type 12	1.45E-01	 	 	 	 	SNTA1	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT4 syndrome	long QT4 syndrome	1.45E-01	 	 	 	 	ANK2	1	
Congenital Heart Anomaly	multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects	multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects	1.45E-01	 	 	 	 	B3GAT3	1	
Cardiac Degeneration	myocytolysis	myocytolysis of heart	1.45E-01	 	 	 	 	MMP9	1	
Liver Inflammation/Hepatitis	necroinflammatory liver disease	necroinflammatory liver disease	1.45E-01	 	 	 	 	ADIPOQ	1	
Nephrosis	nephronophthisis 15	nephronophthisis 15	1.45E-01	 	 	 	 	CEP164	1	
Nephrosis	nephrotic syndrome type 3	nephrotic syndrome type 3	1.45E-01	 	 	 	 	PLCE1	1	
Nephrosis	nephrotic syndrome type 8	nephrotic syndrome type 8	1.45E-01	 	 	 	 	ARHGDIA	1	
Nephrosis	nephrotic syndrome type 9	nephrotic syndrome type 9	1.45E-01	 	 	 	 	ADCK4	1	
Cardiac Necrosis/Cell Death	apoptosis	onset of apoptosis of cardiomyocytes	1.45E-01	 	 	 	 	LEP	1	
Cardiac Hypertrophy	hypertrophy	onset of hypertrophy of cardiomyocytes	1.45E-01	 	 	 	 	LEP	1	
Liver Fibrosis	opisthorchiasis periductal fibrosis	opisthorchiasis periductal fibrosis	1.45E-01	 	 	 	 	IL6	1	
Renal Proliferation	overgrowth	overgrowth of mesangial cells	1.45E-01	 	 	 	 	MST1	1	
Pulmonary Hypertension	primary pulmonary hypertension 3	primary pulmonary hypertension 3	1.45E-01	 	 	 	 	CAV1	1	
Pulmonary Hypertension	primary pulmonary hypertension 4	primary pulmonary hypertension 4	1.45E-01	 	 	 	 	KCNK3	1	
Liver Cholestasis	progressive familial intrahepatic cholestasis type 4	progressive familial intrahepatic cholestasis type 4	1.45E-01	 	 	 	 	TJP2	1	
Cardiac Proliferation	proliferation	proliferation of heart	1.45E-01	 	 	 	 	MAP2K5	1	
Cardiac Necrosis/Cell Death	quantity	quantity of apoptotic ventricular myocytes	1.45E-01	 	 	 	 	MMP2	1	
Cardiac Arrythmia	short-QT syndrome 3	short-QT syndrome 3	1.45E-01	 	 	 	 	KCNJ2	1	
Liver Cirrhosis	primary biliary cirrhosis	stage 3 primary biliary cirrhosis	1.45E-01	 	 	 	 	COL3A1	1	
Liver Cirrhosis	primary biliary cirrhosis	stage 4 primary biliary cirrhosis	1.45E-01	 	 	 	 	COL3A1	1	
Cardiac Stenosis	stenosis	stenosis of tricuspid valve	1.45E-01	 	 	 	 	HEY2	1	
Cardiac Necrosis/Cell Death	survival	survival of cardiac fibroblasts	1.45E-01	 	 	 	 	mir-21	1	
Kidney Failure, Renal Inflammation, Renal Nephritis	susceptibility to progression to renal failure in IgA nephropathy	susceptibility to progression to renal failure in IgA nephropathy	1.45E-01	 	 	 	 	AGT	1	
Renal Transformation	transformation	transformation of mesangial cells	1.45E-01	 	 	 	 	SRC	1	
Renal Dilation	vasodilation	vasodilation of renal artery	1.45E-01	 	 	 	 	MMP9	1	
Renal Atrophy	atrophy	atrophy of renal tubule	1.52E-01	 	-0.747	bias	0.127	LGMN,MMP2,PTGS2,APRT,AGT	5	
Liver Hyperplasia/Hyperproliferation	hepatic hemangioma	hepatic hemangioma	1.55E-01	 	 	 	 	TSC2,VHL	2	
Cardiac Arrythmia	idiopathic ventricular fibrillation	idiopathic ventricular fibrillation	1.55E-01	 	 	 	 	KCNJ8,LMNA	2	
Decreased Levels of Albumin	uptake	increased uptake of albumin	1.55E-01	 	 	 	 	FLNA,CAV1	2	
Renal Inflammation, Renal Nephritis	inflammation	inflammation of kidney component	1.55E-01	 	 	 	 	CFB,APRT	2	
Liver Fibrosis	mitogenesis	mitogenesis of hepatic stellate cells	1.55E-01	 	 	 	 	FGF2,AGT	2	
Cardiac Stenosis	stenosis	stenosis of pulmonary artery	1.55E-01	 	 	 	 	ELN,MGP	2	
Renal Inflammation, Renal Nephritis	focal glomerulonephritis	focal glomerulonephritis	1.56E-01	 	 	 	 	SELE,PSMB5,JUN,CCL2,PSMB2,IMPDH2,DGAT2,AGT	8	
Heart Failure	cardiac decompensation	cardiac decompensation	1.61E-01	 	 	 	 	NPR3,ADRA1A,ADRA1B,ADRB2	4	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	crescentic glomerulonephritis	1.61E-01	 	 	 	 	VCAM1,SPP1,CCL3L3,SMAD7	4	
Liver Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of liver	1.61E-01	 	-1.960	bias	-1.377	XYLT2,TIMP1,SPI1,IGF2R	4	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of kidney	1.64E-01	Decreased	-2.433	bias	-1.412	MYC,LGMN,GADD45A,WAS,HSD11B2,PKN1	6	
Cardiac Arrythmia	Brugada syndrome type 1	Brugada syndrome type 1	1.66E-01	 	 	 	 	KCNJ8,SNTA1,ANK2	3	
Renal Atrophy	atrophy	atrophy of renal medulla	1.66E-01	 	 	 	 	ADAMTS1,APRT,AGT	3	
Cardiac Dysfunction, Heart Failure	diastolic heart failure	diastolic heart failure	1.66E-01	 	 	 	 	CTGF,NPR3,ADRB2	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	inoperable hepatocellular carcinoma	1.66E-01	 	 	 	 	KIT,RET,KDR	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	local hepatocellular carcinoma	1.66E-01	 	 	 	 	KIT,RET,KDR	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	unresectable hepatocellular carcinoma	1.66E-01	 	 	 	 	KIT,RET,KDR	3	
Nephrosis	nephrosis	nephrosis	1.74E-01	 	 	 	 	GSTM1,CEP164,ADCK4,IMPDH2,CA4,FKBP1A,GSTT1,CA3,ITGA3,MTOR,PLCE1,CST3,ARHGDIA,ITGA1,ADORA1	15	
Cardiac Dilation	dilation	dilation of left ventricle	1.77E-01	 	-0.426	 	-0.152	TGFBR2,CAPNS1,SPP1,TIMP1,CAV1,LMNA,CAST,MMP9,ADRB2	9	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	growth	growth of hepatocellular carcinoma	1.77E-01	 	-0.577	bias	-1.436	MYC,TNFSF10,IL6,GPC3,AKR1B10	5	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of podocytes	1.86E-01	 	-0.556	 	-0.887	EDN1,FGF2,PRKCD,SMAD7,PTGS2,AGT	6	
Cardiac Fibrosis	interstitial fibrosis	interstitial fibrosis of heart	1.86E-01	 	0.555	 	0.423	PTX3,CAPNS1,PPP1CB,HRAS,TNFAIP3,AGT	6	
Renal Necrosis/Cell Death	apoptosis	apoptosis of tubular cells	1.94E-01	 	-1.092	 	-0.831	NLRP3,UNC5B,AQP11,MST1,HIF1A,ADORA1,mir-21,AGT	8	
Congenital Heart Anomaly	atrial septal defect	atrial septal defect	1.95E-01	 	-1.195	bias	0.108	DHRS3,ZFPM2,ADRA2A,FLNA,CFC1/CFC1B,SLC19A1,GPC3,MEGF8,ATP2A2	9	
Renal Necrosis/Cell Death	cell death	cell death of tubular cells	1.95E-01	 	-0.761	 	-0.455	NLRP3,CAT,UNC5B,AQP11,MST1,HIF1A,ADORA1,mir-21,AGT	9	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	advanced stage hepatocellular carcinoma	2.04E-01	 	 	 	 	POR,KIT,ING1,RET,KDR	5	
Cardiac Fibrosis	fibrosis	fibrosis of left ventricle	2.04E-01	 	1.432	 	1.332	PTX3,ADRA2A,GSK3B,ADRB2,AGT	5	
Cardiac Damage	damage	damage of myocardium	2.05E-01	 	 	 	 	GDF15,ADIPOQ,AGT	3	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal glomerulus	2.05E-01	 	 	 	 	MAN2C1,STAB1,PTGS2	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	tumorigenesis	tumorigenesis of hepatocellular carcinoma	2.10E-01	 	0.896	 	0.639	MYC,SOCS3,ALDH2,LTBR,PSME3,VCAN	6	
Congenital Heart Anomaly	double aortic arch	double aortic arch	2.11E-01	 	 	 	 	EDNRA,NRP1	2	
Increased Levels of Albumin	excretion	increased excretion of albumin	2.11E-01	 	 	 	 	P2RX7,AGT	2	
Increased Levels of ALT	release	increased release of ALT	2.11E-01	 	 	 	 	SPP1,IL6	2	
Liver Steatosis	hepatic steatosis	severe hepatic steatosis	2.11E-01	 	 	 	 	UCP2,ESR1	2	
Cardiac Stenosis	stenosis	stenosis of pulmonary valve	2.11E-01	 	 	 	 	NTRK3,HBEGF	2	
Heart Failure	sudden cardiac death	sudden cardiac death	2.11E-01	 	 	 	 	ANK2,DSG2	2	
Renal Inflammation, Renal Nephritis	tubular nephritis	tubular nephritis	2.11E-01	 	 	 	 	ITGA1,MDK	2	
Congenital Heart Anomaly	persistent truncus arteriosus	persistent truncus arteriosus	2.13E-01	 	-0.653	bias	0.628	DVL2,JUN,FLNA,RARA,EDNRA,DVL3,NRP1	7	
Increased Levels of Creatinine	quantity	increased quantity of creatinine	2.14E-01	 	 	 	 	CTGF,BCAT2,ST6GALNAC2,HSD11B2,MST1,IL6,AKR1B1,AGT	8	
Renal Dysplasia	dysplasia	dysplasia of kidney	2.24E-01	 	 	 	 	H19,RET,VHL,AGT	4	
Liver Damage, Liver Inflammation/Hepatitis	hepatitis C	hepatitis C	2.31E-01	 	 	 	 	POR,BCL2L1,CXCL8,MTOR,KRT8,LEP,SPP1,CCL2,IMPDH2,GAA,ADIPOQ,FKBP1A,IL6,IFNAR2	14	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	development	development of hepatocellular carcinoma	2.32E-01	 	 	 	 	JUN,RARA,MGMT,IL6,AGT	5	
Renal Inflammation, Renal Nephritis	nephritis	Nephritis	2.34E-01	 	-0.488	bias	1.117	C1QA,IL6,APRT,CTNS,CXCL8,SELE,PSMB5,SPP1,HBEGF,GPX7,PKN1,EFS,ITGAM,PKD1,PSMB2,PRKCD,CD86,IDO1,ITGA1,MDK,ESR1,TNS1,FYN,COL4A5,LEP,GADD45B,DDIT3,TNFAIP3,FKBP1A,HIF1A,ASNS,TGM2,SLC19A3,HMOX1,MTOR,NFKBIA,JUN,CCL2,GADD45A,CCL3L3,CFB,RASSF5,MAPKAPK2,FCGR3A/FCGR3B,AGT,CCR1,VCAM1,EPAS1,C5AR1,IMPDH2,SMAD7,DGAT2,LRRK2,CXCL16,WAS,BMF,LYN,ARHGDIA,PLEKHA2,PTGS2,KDR,MMP9	62	
Renal Inflammation, Renal Nephritis	IgA nephropathy	IgA nephropathy	2.35E-01	 	 	 	 	SELE,PSMB5,JUN,PSMB2,IMPDH2,DGAT2,AGT	7	
Liver Cholestasis	intrahepatic cholestasis	intrahepatic cholestasis	2.36E-01	 	 	 	 	ABCB6,SLC25A13,TJP2,SLC25A6,CYP27A1,CD68,AKR1C3,SLC12A2,ADH1C,ABCG1,LBP,SLC35B1,GJB2	13	
Glomerular Injury	expansion	expansion of mesangial matrix	2.46E-01	 	 	 	 	LEP,ITGA1,AGT	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	metastatic hepatocellular carcinoma	metastatic hepatocellular carcinoma	2.46E-01	 	 	 	 	KIT,RET,KDR	3	
Cardiac Proliferation	proliferation	proliferation of cardiac fibroblasts	2.46E-01	 	 	 	 	FGF2,ADIPOQ,HBEGF	3	
Renal Hypoplasia	hypoplasia	hypoplasia of kidney	2.48E-01	 	0.312	bias	1.628	SLIT3,GPR4,ALDH1A3,PCSK5,RARA,SPRY2,ALDH1A2,ARHGDIA,PTGS2,RET	10	
Renal Hypoplasia	agenesis	agenesis of kidney	2.57E-01	 	 	 	 	SLIT3,PCSK5,SPRY2,RET	4	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction	2.60E-01	 	 	 	 	CTGF,LEP,NPR3,HRAS,SLC27A1,ADRB2	6	
Renal Damage	reperfusion injury	reperfusion injury of kidney	2.60E-01	 	-0.418	 	-0.921	CD55,C5AR1,THBS1,UNC5B,CFB,mir-21	6	
Cardiac Dysfunction	systolic dysfunction	systolic dysfunction	2.60E-01	 	 	 	 	CSF3R,LEP,ADRBK1,ANXA5,FKBP1A,ADRB2	6	
Liver Cholestasis	progressive intrahepatic cholestasis	progressive intrahepatic cholestasis	2.62E-01	 	 	 	 	ABCB6,SLC25A13,TJP2,SLC25A6,CYP27A1,AKR1C3,SLC12A2,ADH1C,ABCG1,LBP,SLC35B1	11	
Cardiac Arrythmia, Congenital Heart Anomaly	Andersen's syndrome	Andersen's syndrome	2.68E-01	 	 	 	 	KCNJ2	1	
Liver Hyperbilirubinemia	Dubin-Johnson syndrome	Dubin-Johnson syndrome	2.68E-01	 	 	 	 	ABCC3	1	
Liver Inflammation/Hepatitis	acute inflammation	acute inflammation of liver	2.68E-01	 	 	 	 	RHBDD3	1	
Renal Inflammation, Renal Nephritis	acute proliferative glomerulonephritis	acute proliferative glomerulonephritis	2.68E-01	 	 	 	 	MAPKAPK2	1	
Renal Inflammation, Renal Nephritis	acute pyelonephritis	acute pyelonephritis	2.68E-01	 	 	 	 	KDR	1	
Liver Adhesion	adhesion	adhesion of hepatic stellate cells	2.68E-01	 	 	 	 	CTGF	1	
Cardiac Arteriopathy	atherosclerosis	atherosclerosis of coronary artery	2.68E-01	 	 	 	 	APOE	1	
Liver Hyperplasia/Hyperproliferation	beta-catenin activating mutation positive hepatocellular adenoma	beta-catenin activating mutation positive hepatocellular adenoma	2.68E-01	 	 	 	 	GLUL	1	
Liver Congestion	congestion	congestion of liver	2.68E-01	 	 	 	 	HEY2	1	
Liver Cirrhosis	cryptogenic cirrhosis	cryptogenic cirrhosis	2.68E-01	 	 	 	 	KRT8	1	
Decreased Levels of Albumin	production	decreased production of albumin	2.68E-01	 	 	 	 	IL6	1	
Cardiac Degeneration	degeneration	degeneration of heart tissue	2.68E-01	 	 	 	 	SGCD	1	
Liver Hyperplasia/Hyperproliferation	tumorigenesis	delay in tumorigenesis of liver	2.68E-01	 	 	 	 	MYC	1	
Renal Damage	drug toxicity-related nephropathy	drug toxicity-related nephropathy	2.68E-01	 	 	 	 	GSS	1	
Cardiac Arrythmia	early repolarization syndrome	early repolarization syndrome	2.68E-01	 	 	 	 	KCNJ8	1	
Liver Cholestasis	ethynylestradiol hepatocellular cholestasis	ethynylestradiol hepatocellular cholestasis	2.68E-01	 	 	 	 	GJB2	1	
Liver Proliferation	expansion	expansion of oval cells	2.68E-01	 	 	 	 	TNFRSF12A	1	
Liver Steatosis	experimental nonalcoholic fatty liver disease	experimental nonalcoholic fatty liver disease	2.68E-01	 	 	 	 	ADIPOQ	1	
Liver Necrosis/Cell Death	focal necrosis	focal necrosis of liver cells	2.68E-01	 	 	 	 	APOE	1	
Glomerular Injury	glomerular cyst	glomerular cyst	2.68E-01	 	 	 	 	LGMN	1	
Liver Inflammation/Hepatitis	granulomatous hepatitis	granulomatous hepatitis	2.68E-01	 	 	 	 	CCL8	1	
Liver Inflammation/Hepatitis	hepatitis subtype infantile hepatitis syndrome	hepatitis subtype infantile hepatitis syndrome	2.68E-01	 	 	 	 	IL6	1	
Biliary Hyperplasia	hyperplasia	hyperplasia of biliary epithelial cells	2.68E-01	 	 	 	 	MYC	1	
Cardiac Enlargement	hypertrichotic osteochondrodysplasia	hypertrichotic osteochondrodysplasia	2.68E-01	 	 	 	 	ABCC9	1	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of podocytes	2.68E-01	 	 	 	 	AGT	1	
Renal Hypertrophy	hypertrophy	hypertrophy of proximal tubule cells	2.68E-01	 	 	 	 	AGT	1	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular myocardium	2.68E-01	 	 	 	 	IL6	1	
Increased Levels of Potassium	efflux	increased efflux of K+	2.68E-01	 	 	 	 	P2RX7	1	
Increased Levels of CRP	synthesis	increased synthesis of CRP	2.68E-01	 	 	 	 	IL6	1	
Liver Inflammation/Hepatitis	infantile cholestatic hepatitis syndrome	infantile cholestatic hepatitis syndrome	2.68E-01	 	 	 	 	IL6	1	
Renal Inflammation, Renal Nephritis	infantile nephropathic cystinosis	infantile nephropathic cystinosis	2.68E-01	 	 	 	 	CTNS	1	
Liver Inflammation/Hepatitis	inflammation	inflammation of liver portal space	2.68E-01	 	 	 	 	SPARC	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	growth	initiation of growth of hepatocellular carcinoma	2.68E-01	 	 	 	 	MYC	1	
Liver Regeneration	regeneration	initiation of regeneration of liver	2.68E-01	 	 	 	 	IL6	1	
Renal Damage, Renal Tubule Injury	injury	injury of tubulointerstitium	2.68E-01	 	 	 	 	CCR1	1	
Glomerular Injury	lipidosis	lipidosis of renal glomerulus	2.68E-01	 	 	 	 	APOE	1	
Cardiac Necrosis/Cell Death	necrosis	necrosis of left ventricle	2.68E-01	 	 	 	 	AGT	1	
Liver Inflammation/Hepatitis, Liver Necrosis/Cell Death	necrotizing inflammation	necrotizing inflammation of liver	2.68E-01	 	 	 	 	APOE	1	
Cardiac Arrythmia	non-valvular atrial fibrillation	non-valvular atrial fibrillation	2.68E-01	 	 	 	 	VKORC1	1	
Renal Inflammation, Renal Nephritis	passive Heymann nephritis	passive Heymann nephritis	2.68E-01	 	 	 	 	HBEGF	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis	persistent chronic hepatitis	2.68E-01	 	 	 	 	THOP1	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	poorly differentiated hepatocellular carcinoma	2.68E-01	 	 	 	 	ING1	1	
Cardiac Hypertrophy	pressure overload hypertrophy	pressure overload hypertrophy	2.68E-01	 	 	 	 	ADGRG1	1	
Kidney Failure	progressive myoclonic epilepsy type 4 with renal failure	progressive myoclonic epilepsy type 4 with renal failure	2.68E-01	 	 	 	 	GBA	1	
Cardiac Proliferation	proliferation	proliferation of adventitial fibroblasts	2.68E-01	 	 	 	 	ADIPOQ	1	
Cardiac Proliferation	proliferation	proliferation of cardiac stem cells	2.68E-01	 	 	 	 	GNL3	1	
Renal Regeneration	regeneration	regeneration of glomerular capillary	2.68E-01	 	 	 	 	THY1	1	
Cardiac Damage	reperfusion injury	reperfusion injury of myocardium	2.68E-01	 	 	 	 	ADIPOQ	1	
Glomerular Injury	sclerosis	sclerosis of renal glomerulus	2.68E-01	 	 	 	 	AGT	1	
Liver Fibrosis	hepatic fibrosis	severe hepatic fibrosis	2.68E-01	 	 	 	 	COL3A1	1	
Glomerular Injury, Renal Fibrosis	renal fibrosis	severe renal fibrosis	2.68E-01	 	 	 	 	SMAD7	1	
Cardiac Arteriopathy	stenosis	stenosis of coronary artery	2.68E-01	 	 	 	 	SGCD	1	
Liver Cirrhosis	susceptibility to noncryptogenic cirrhosis	susceptibility to noncryptogenic cirrhosis	2.68E-01	 	 	 	 	KRT8	1	
Cardiac Arteriopathy	susceptibility to severe coronary artery disease	susceptibility to severe coronary artery disease	2.68E-01	 	 	 	 	APOE	1	
Heart Failure	heart failure	symptomatic stage hypertensive heart failure	2.68E-01	 	 	 	 	ADRB2	1	
Heart Failure	heart failure	symptomatic stage ischemic heart failure	2.68E-01	 	 	 	 	ADRB2	1	
Heart Failure	cardiomyopathic heart failure	symptomatic stage stable cardiomyopathic heart failure	2.68E-01	 	 	 	 	ADRB2	1	
Renal Hypoplasia	unilateral renal agenesis	unilateral renal agenesis	2.68E-01	 	 	 	 	SPRY2	1	
Liver Cirrhosis	primary biliary cirrhosis	early stage primary biliary cirrhosis	2.68E-01	 	 	 	 	LDLR,APOB	2	
Cardiac Enlargement	enlargement	enlargement of cardiomyocytes	2.68E-01	 	 	 	 	EDN1,KLF4	2	
Increased Levels of Bilirubin	quantity	increased quantity of bilirubin	2.68E-01	 	 	 	 	ATF3,LEP	2	
Cardiac Damage	injury	injury of myocardium	2.68E-01	 	 	 	 	ADIPOQ,AGT	2	
Liver Hyperplasia/Hyperproliferation	polycystic liver disease	polycystic liver disease	2.68E-01	 	 	 	 	XYLT2,PRKCSH	2	
Renal Proliferation	proliferation	proliferation of podocytes	2.68E-01	 	 	 	 	SRC,DUSP1	2	
Liver Enlargement, Liver Hepatomegaly	hepatomegaly	hepatomegaly	2.71E-01	 	 	 	 	MIF,ADIPOQ,MST1,LMNA,SMPD1,BSCL2,AGL,IGF2R,TYSND1,CTSA,GBA,CBS/CBSL,ESR1,ARID4A,HADHA	15	
Cardiac Arrythmia	familial atrial fibrillation	familial atrial fibrillation	2.88E-01	 	 	 	 	NUP155,KCNJ2,ABCC9	3	
Renal Damage	injury	injury of kidney cells	2.88E-01	 	 	 	 	FGF2,CAT,AGT	3	
Biliary Hyperplasia	proliferation	proliferation of biliary epithelial cells	2.88E-01	 	 	 	 	FGF2,IL6,MAP2K5	3	
Cardiac Arrythmia	arrhythmogenic right ventricular dysplasia	arrhythmogenic right ventricular dysplasia	2.91E-01	 	 	 	 	PKP2,SNTA1,LMNA,DSG2	4	
Renal Inflammation, Renal Nephritis	interstitial nephritis	interstitial nephritis	2.91E-01	 	-0.152	bias	0.830	ARHGDIA,PTGS2,TNS1,AGT	4	
Glomerular Injury, Kidney Failure, Renal Fibrosis	interstitial fibrosis	interstitial fibrosis of kidney	2.93E-01	 	-0.441	bias	0.536	STC1,LGMN,SGCG,PKD1,ADIPOQ,MMP2,PTGS2,APRT,AGT	9	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis	chronic hepatitis	3.06E-01	 	 	 	 	CXCL8,SPP1,LEP,IMPDH2,TNFRSF10B,ADIPOQ,FKBP1A,THOP1,IL6,IFNAR2,POLD1,POR,BCL2L1,MTOR,KRT8,CCL2,TIMP1,GAA,STAB1,LTBR,MMP9,COL3A1	22	
Cardiac Arrythmia	familial arrhythmia	familial arrhythmia	3.06E-01	 	 	 	 	KCNJ8,NUP155,KCNJ2,SNTA1,ANK2,HEY2,ABCC9	7	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cell lines	3.13E-01	 	-0.555	 	-0.896	MYC,GADD45B,TIMP1,TNFSF10,PTGS2,IER3	6	
Liver Degeneration	degeneration	degeneration of liver	3.13E-01	 	-0.928	bias	0.044	ERCC1,TYRO3,GSK3B,IL6,AXL,ESR1	6	
Cardiac Arrythmia, Tachycardia	supraventricular tachycardia	supraventricular tachycardia	3.13E-01	 	 	 	 	ADRA2A,ATP1A2,ADORA1,ADRA1A,ADRA1B,ADRB2	6	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis C	chronic hepatitis C	3.17E-01	 	 	 	 	POR,BCL2L1,CXCL8,LEP,SPP1,CCL2,IMPDH2,GAA,ADIPOQ,IL6,IFNAR2	11	
Cardiac Arrythmia, Tachycardia	paroxysmal supraventricular tachycardia	paroxysmal supraventricular tachycardia	3.20E-01	 	 	 	 	ADRA2A,ADORA1,ADRA1A,ADRA1B,ADRB2	5	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	acute phase crescentic glomerulonephritis	3.26E-01	 	 	 	 	VCAM1,CCL3L3	2	
Liver Fibrosis	chemotaxis	chemotaxis of hepatic stellate cells	3.26E-01	 	 	 	 	CCL2,FGF2	2	
Liver Regeneration	regeneration	regeneration of hepatocytes	3.26E-01	 	 	 	 	ELK1,MMP9	2	
Cardiac Fibrosis	fibrosis	fibrosis of myocardium	3.26E-01	 	-0.343	 	-0.060	TIMP1,SGCD,MMP9,AGT	4	
Liver Damage	damage	damage of hepatocytes	3.30E-01	 	 	 	 	FAAH,MIF,EGR1	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	progressive liver metastasis	3.30E-01	 	 	 	 	KIT,RET,KDR	3	
Liver Proliferation	proliferation	proliferation of oval cells	3.30E-01	 	 	 	 	CXCR4,CXCL12,TNFRSF12A	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	symptomatic stage iodine-refractory liver metastasis	3.30E-01	 	 	 	 	KIT,RET,KDR	3	
Liver Cholestasis	progressive familial intrahepatic cholestasis type 1	progressive familial intrahepatic cholestasis type 1	3.46E-01	 	 	 	 	ABCB6,SLC25A13,SLC25A6,CYP27A1,AKR1C3,SLC12A2,ADH1C,ABCG1,LBP,SLC35B1	10	
Liver Steatosis	nonalcoholic fatty liver disease	nonalcoholic fatty liver disease	3.55E-01	 	 	 	 	LEP,UCP2,CCL2,PLIN2,CAT,ADIPOQ,ACSL4,LIPE,ACACA,HADHA,mir-21	11	
Cardiac Arrythmia	Brugada syndrome	Brugada syndrome	3.61E-01	 	 	 	 	KCNJ8,SNTA1,ANK2,HEY2	4	
Renal Inflammation, Renal Nephritis	membranous glomerulonephritis	membranous glomerulonephritis	3.61E-01	 	 	 	 	IMPDH2,HBEGF,FKBP1A,IDO1	4	
Cardiac Arrythmia, Congenital Heart Anomaly	congenital long QT syndrome	congenital long QT syndrome	3.72E-01	 	 	 	 	KCNJ2,SNTA1,ANK2	3	
Liver Cirrhosis	alcoholic cirrhosis	alcoholic cirrhosis	3.74E-01	 	 	 	 	MMP9	1	
Liver Steatosis	alcoholic fatty liver disease	alcoholic fatty liver disease	3.74E-01	 	 	 	 	ADIPOQ	1	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of cardiac stem cells	3.74E-01	 	 	 	 	SFRP2	1	
Cardiac Hypertrophy	atrial hypertrophy	atrial hypertrophy	3.74E-01	 	 	 	 	ATF3	1	
Nephrosis	autosomal recessive steroid-resistant nephrotic syndrome	autosomal recessive steroid-resistant nephrotic syndrome	3.74E-01	 	 	 	 	IMPDH2	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic non-A, non-B hepatitis	chronic non-A, non-B hepatitis	3.74E-01	 	 	 	 	IFNAR2	1	
Renal Dysfunction	dysfunction	dysfunction of podocytes	3.74E-01	 	 	 	 	SRC	1	
Liver Damage	histopathological change	histopathological change of liver	3.74E-01	 	 	 	 	LRRK2	1	
Cardiac Arteriopathy, Cardiac Hypertrophy	hypertrophy	hypertrophy of coronary artery	3.74E-01	 	 	 	 	AGT	1	
Renal Inflammation, Renal Nephritis	idiopathic membranous nephropathy	idiopathic membranous nephropathy	3.74E-01	 	 	 	 	FKBP1A	1	
Increased Levels of Alkaline Phosphatase	localization	increased localization of alkaline phosphatase	3.74E-01	 	 	 	 	ATF3	1	
Liver Cholestasis	obstruction	obstruction of bile duct	3.74E-01	 	 	 	 	GJB2	1	
Liver Cholestasis	obstructive jaundice	obstructive jaundice	3.74E-01	 	 	 	 	CAT	1	
Pulmonary Hypertension	persistent fetal circulation syndrome	persistent fetal circulation syndrome	3.74E-01	 	 	 	 	EDNRA	1	
Liver Necrosis/Cell Death	quantity	quantity of apoptotic hepatocytes	3.74E-01	 	 	 	 	TNFSF10	1	
Glutathione Depletion In Liver, Liver Fibrosis	quantity	quantity of reactive oxygen species in liver	3.74E-01	 	 	 	 	DNM1L	1	
Cardiac Infarction	myocardial infarction	recurrent myocardial infarction	3.74E-01	 	 	 	 	VKORC1	1	
Renal Dysplasia, Renal Hypoplasia	renal hypodysplasia/aplasia type 1	renal hypodysplasia/aplasia type 1	3.74E-01	 	 	 	 	RET	1	
Cardiac Damage	rupture	rupture of myocardium	3.74E-01	 	 	 	 	GDF15	1	
Liver Cholestasis	secretion	secretion of taurocholic acid	3.74E-01	 	 	 	 	HMOX1	1	
Glomerular Injury	size	size of glomerular crescent	3.74E-01	 	 	 	 	PLAT	1	
Liver Inflammation/Hepatitis	susceptibility to hepatitis B virus	susceptibility to hepatitis B virus	3.74E-01	 	 	 	 	IFNAR2	1	
Liver Damage, Liver Inflammation/Hepatitis	susceptibility to hepatitis C virus	susceptibility to hepatitis C virus	3.74E-01	 	 	 	 	KRT8	1	
Glomerular Injury, Kidney Failure, Renal Fibrosis	tubulo-interstitial fibrosis	tubulo-interstitial fibrosis of skeletal muscle	3.74E-01	 	 	 	 	SGCG	1	
Congenital Heart Anomaly	ventricular septal defect type 3	ventricular septal defect type 3	3.74E-01	 	 	 	 	GPC3	1	
Liver Hyperplasia/Hyperproliferation	metastasis	metastasis of liver	3.78E-01	 	0.000	 	-0.308	NDRG1,CCL2,CXCR4,KIT,PLAUR,IL6,RET,KDR,PRNP	9	
Liver Hyperplasia/Hyperproliferation	tumorigenesis	tumorigenesis of liver tumor	3.81E-01	 	0.342	 	0.105	MYC,SOCS3,ALDH2,LTBR,CUL9,PSME3,VCAN	7	
Increased Levels of Potassium	quantity	increased quantity of K+	3.82E-01	 	 	 	 	STK39,HSD11B2	2	
Congenital Heart Anomaly	tetralogy of Fallot	tetralogy of Fallot	3.82E-01	 	 	 	 	ZFPM2,HEY2	2	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubular epithelial cells	3.96E-01	 	-0.882	 	-0.650	NLRP3,UNC5B,MST1,mir-21	4	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of kidney cells	3.96E-01	 	-1.982	bias	-1.000	LGMN,GADD45A,WAS,PKN1	4	
Kidney Failure	end stage renal disease	end stage renal disease	3.99E-01	 	-0.120	bias	0.960	CXCL8,GSTM1,SGCG,ATP2C1,IMPDH2,ADIPOQ,FKBP1A,MMP2,GSS,GSTT1,GABRE,APRT,STC1,MTOR,LGMN,PKD1,PDE3B,IDO1,PTGS2,ADORA1,FCGR3A/FCGR3B,AGT	22	
Cardiac Arrythmia, Tachycardia	hemodynamically unstable ventricular tachycardia	hemodynamically unstable ventricular tachycardia	4.14E-01	 	 	 	 	KCNK3,KCNJ2,THRA	3	
Renal Damage, Renal Tubule Injury	injury	injury of renal tubule	4.14E-01	 	 	 	 	CCR1,CAT,CFB	3	
Cardiac Arrythmia	ventricular fibrillation	recurrent ventricular fibrillation	4.14E-01	 	 	 	 	KCNK3,KCNJ2,THRA	3	
Liver Regeneration	regeneration	regeneration of liver cells	4.14E-01	 	 	 	 	IL6,ELK1,MMP9	3	
Liver Regeneration	regeneration	regeneration of liver	4.24E-01	 	-0.426	bias	-1.456	SOCS3,LEP,EGR1,TOB1,IL6,GPC3,ODC1,IKBKG,CAV1,PTGS2,ELK1,SULF2,MMP9	13	
Cardiac Arrythmia	chronic atrial fibrillation	chronic atrial fibrillation	4.36E-01	 	 	 	 	ATP1A2,ATP2A2	2	
Hepatocellular Peroxisome Proliferation	formation	formation of peroxisomes	4.36E-01	 	 	 	 	PEX6,PEX16	2	
Glomerular Injury, Renal Damage	injury	injury of podocytes	4.36E-01	 	 	 	 	FGF2,AGT	2	
Cardiac Damage	rupture	rupture of heart	4.36E-01	 	 	 	 	GDF15,MMP9	2	
Renal Necrosis/Cell Death	survival	survival of podocytes	4.36E-01	 	 	 	 	PARVA,FAT1	2	
Cardiac Thrombosis	thrombosis	thrombosis of atrium	4.36E-01	 	 	 	 	HBEGF,ADRB2	2	
Renal Proliferation	proliferation	proliferation of tubular cells	4.55E-01	 	 	 	 	AQP11,MST1,AGT	3	
Glomerular Injury	bleeding	bleeding of renal glomerulus	4.65E-01	 	 	 	 	GPR4	1	
Cardiac Output	cardiac index	cardiac index	4.65E-01	 	 	 	 	TNFSF10	1	
Decreased Levels of Albumin	secretion	decreased secretion of albumin	4.65E-01	 	 	 	 	IL6	1	
Decreased Levels of Albumin	synthesis	decreased synthesis of albumin	4.65E-01	 	 	 	 	IL6	1	
Liver Regeneration	regeneration	delay in regeneration of liver	4.65E-01	 	 	 	 	SULF2	1	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal tubule	4.65E-01	 	 	 	 	APRT	1	
Hepatocellular Peroxisome Proliferation	formation	formation of peroxisome membrane	4.65E-01	 	 	 	 	PEX16	1	
Cardiac Hypoplasia	hypoplasia	hypoplasia of atrium	4.65E-01	 	 	 	 	ADRBK1	1	
Renal Hypoplasia	hypoplasia	hypoplasia of renal medulla	4.65E-01	 	 	 	 	PTGS2	1	
Glomerular Injury, Renal Inflammation, Renal Nephritis	inflammation	inflammation of renal glomerulus	4.65E-01	 	 	 	 	CFB	1	
Cardiac Dysfunction	left ventricular diastolic dysfunction	left ventricular diastolic dysfunction	4.65E-01	 	 	 	 	ADRB2	1	
Congenital Heart Anomaly	mesocardia	mesocardia	4.65E-01	 	 	 	 	CFC1/CFC1B	1	
Heart Failure	heart failure	mild to moderate stage heart failure	4.65E-01	 	 	 	 	ATP1A2	1	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	progressive crescentic glomerulonephritis	4.65E-01	 	 	 	 	VCAM1	1	
Renal Dysplasia	renal tubular dysgenesis	renal tubular dysgenesis	4.65E-01	 	 	 	 	AGT	1	
Heart Failure	heart failure	severe heart failure	4.65E-01	 	 	 	 	CAMK2D	1	
Cardiac Arrythmia, Tachycardia	sustained ventricular tachycardia	sustained ventricular tachycardia	4.65E-01	 	 	 	 	ADRB2	1	
Cardiac Arrythmia	atrial fibrillation	symptomatic stage atrial fibrillation	4.65E-01	 	 	 	 	ADRB2	1	
Cardiac Arrythmia, Tachycardia	torsades de pointes	torsades de pointes	4.65E-01	 	 	 	 	ANK2	1	
Cardiac Transformation	transformation	transformation of endocardial cells	4.65E-01	 	 	 	 	MMP2	1	
Liver Hyperplasia/Hyperproliferation	benign neoplasm of liver	benign neoplasm of liver	4.77E-01	 	 	 	 	CBX7,MTOR,TSC2,GLUL,CYP1B1,VHL	6	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction of heart	4.87E-01	 	 	 	 	LEP,HRAS	2	
Cardiac Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of heart	4.87E-01	 	 	 	 	ABL1,IGF2R	2	
Cardiac Hypertrophy	hypertrophy	hypertrophy of myocardium	4.87E-01	 	 	 	 	IL6,AGT	2	
Liver Inflammation/Hepatitis	viral hepatitis	viral hepatitis	4.91E-01	 	 	 	 	CXCL8,SPP1,LEP,IMPDH2,TNFRSF10B,ADIPOQ,FKBP1A,IL6,IFNAR2,POLD1,POR,BCL2L1,MTOR,KRT8,CCL2,TIMP1,GAA,FCGR3A/FCGR3B,MMP9,COL3A1	20	
Cardiac Inflammation	pericarditis	pericarditis	4.94E-01	 	 	 	 	TUBG1,TUBB2A,TUBA1C	3	
Liver Proliferation	quantity	quantity of hepatocytes	4.94E-01	 	 	 	 	CBS/CBSL,ATF4,MDK	3	
Kidney Failure	chronic renal failure	chronic renal failure	5.10E-01	 	-0.120	bias	0.960	ADM,CXCL8,GSTM1,APOB,SGCG,IMPDH2,ATP2C1,ADIPOQ,FKBP1A,MMP2,GSS,GSTT1,GABRE,APRT,STC1,MTOR,LDLR,LGMN,PKD1,PDE3B,IDO1,PTGS2,ADORA1,FCGR3A/FCGR3B,AGT	25	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	incidence	incidence of hepatocellular carcinoma	5.29E-01	 	0.570	bias	1.665	SPTBN1,CBX7,IKBKG,LEP,HRAS,IL6,RASSF5,CCDC80	8	
Cardiac Inflammation	carditis	carditis	5.30E-01	 	-1.664	 	-1.329	ITGAM,CCL2,CCL3L3,TUBG1,PPP1R15A,TUBB2A,ADIPOQ,TUBA1C,KLF2,MMP9	10	
Liver Damage	hepatotoxicity	hepatotoxicity	5.30E-01	 	 	 	 	ALDH1A1,TIPARP,KCNIP4,ALDH3A1,GSS	5	
Cardiac Arrythmia	long-QT syndrome	long-QT syndrome	5.30E-01	 	 	 	 	SLC2A5,KCNJ2,SNTA1,ANK2,PI4KA	5	
Liver Hematopoiesis	hematopoiesis	hematopoiesis of liver	5.32E-01	 	 	 	 	CIAPIN1,FOS,SOCS3	3	
Cardiac Arrythmia	paroxysmal familial ventricular fibrillation	paroxysmal familial ventricular fibrillation	5.35E-01	 	 	 	 	PKP2,SNTA1	2	
Biliary Hyperplasia	proliferation	proliferation of cholangiocytes	5.35E-01	 	 	 	 	FGF2,IL6	2	
Cardiac Damage	reperfusion injury	reperfusion injury of heart	5.35E-01	 	 	 	 	ADIPOQ,mir-21	2	
Liver Damage, Liver Inflammation/Hepatitis	acute hepatitis C	acute hepatitis C	5.42E-01	 	 	 	 	IFNAR2	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of oval cells	5.42E-01	 	 	 	 	BMF	1	
Pulmonary Hypertension	chronic thromboembolic pulmonary hypertension	chronic thromboembolic pulmonary hypertension	5.42E-01	 	 	 	 	EDNRA	1	
Renal Proliferation	cytostasis	cytostasis of kidney cell lines	5.42E-01	 	 	 	 	UBE2M	1	
Liver Damage	drug-induced hepatotoxicity	drug-induced hepatotoxicity	5.42E-01	 	 	 	 	GSS	1	
Cardiac Enlargement	enlargement	enlargement of atrium	5.42E-01	 	 	 	 	GSK3B	1	
Renal Inflammation, Renal Nephritis	experimental crescentic glomerulonephritis	experimental crescentic glomerulonephritis	5.42E-01	 	 	 	 	SPP1	1	
Cardiac Arteriopathy, Cardiac Fibrosis	fibrosis	fibrosis of coronary artery	5.42E-01	 	 	 	 	AGT	1	
Glutathione Depletion In Liver, Liver Fibrosis	generation	generation of reactive oxygen species in liver	5.42E-01	 	 	 	 	LEPR	1	
Renal Inflammation, Renal Nephritis	immune complex nephritis	immune complex nephritis	5.42E-01	 	 	 	 	TGM2	1	
Cardiac Inflammation	inflammation	inflammation of myocardium	5.42E-01	 	 	 	 	AGT	1	
Cardiac Dysfunction	left ventricular systolic dysfunction	left ventricular systolic dysfunction	5.42E-01	 	 	 	 	CSF3R	1	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of glomerular capillary	5.42E-01	 	 	 	 	APOE	1	
Liver Hyperplasia/Hyperproliferation	incidence	incidence of liver tumor	5.49E-01	 	-0.388	bias	0.710	SPTBN1,RBM38,CBX7,IKBKG,LEP,SRPX,HRAS,IL6,RASSF5,CCDC80	10	
Glomerular Injury, Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of mesangial cells	5.69E-01	 	 	 	 	GADD45A,WAS,PKN1	3	
Cardiac Arrythmia, Congenital Heart Anomaly	Romano-Ward syndrome	Romano-Ward syndrome	5.80E-01	 	 	 	 	SNTA1,ANK2	2	
Glutathione Depletion In Liver, Liver Fibrosis	production	production of reactive oxygen species in liver	5.80E-01	 	 	 	 	CAT,SMPD1	2	
Decreased Levels of Albumin	activation	decreased activation of albumin	6.08E-01	 	 	 	 	UBE2I	1	
Cardiac Dysfunction	dysfunction	dysfunction of cardiomyocytes	6.08E-01	 	 	 	 	ALDH2	1	
Liver Dysplasia	dysplasia	dysplasia of liver	6.08E-01	 	 	 	 	RARA	1	
Cardiac Arrythmia	ventricular extrasystole	ventricular extrasystole	6.08E-01	 	 	 	 	CASQ2	1	
Cardiac Infarction	acute myocardial infarction	acute myocardial infarction	1.00E00	 	 	 	 	PTX3,GSTM1,TUBG1,TUBB2A,ADIPOQ,CXCL12,F13A1,IL6,EDN1,TUBA1C,ADORA1,FCGR3A/FCGR3B,AGT,PLAT	14	
Cardiac Arrythmia	atrial flutter	atrial flutter	1.00E00	 	 	 	 	ADRA2A,KCNMA1,ADRA1A,ADRA1B,ADRB2	5	
Liver Damage, Liver Inflammation/Hepatitis	chronic viral hepatitis	chronic viral hepatitis	1.00E00	 	 	 	 	POR,BCL2L1,CXCL8,LEP,SPP1,CCL2,TIMP1,IMPDH2,GAA,TNFRSF10B,ADIPOQ,IL6,IFNAR2,POLD1,MMP9	15	
Kidney Failure	chronic kidney disease	end-stage chronic kidney disease	1.00E00	 	 	 	 	ATP2C1,GABRE	2	
Renal Inflammation, Renal Nephritis	glomerulonephritis	glomerulonephritis	1.00E00	 	-1.141	 	-0.064	FYN,GADD45B,DDIT3,FKBP1A,TNFAIP3,C1QA,IL6,ASNS,HMOX1,MTOR,NFKBIA,JUN,GADD45A,CCL2,CCL3L3,RASSF5,MAPKAPK2,FCGR3A/FCGR3B,AGT,CCR1,VCAM1,SELE,C5AR1,SPP1,PSMB5,IMPDH2,DGAT2,SMAD7,HBEGF,GPX7,PKN1,CXCL16,WAS,PSMB2,BMF,PRKCD,LYN,CD86,IDO1,PLEKHA2,PTGS2,ESR1,MMP9	43	
Liver Inflammation/Hepatitis	hepatitis B	hepatitis B	1.00E00	 	 	 	 	TIMP1,TNFRSF10B,IL6,IFNAR2,POLD1,FCGR3A/FCGR3B	6	
Increased Levels of LDH	activation	increased activation of LDH	1.00E00	 	 	 	 	FGF2	1	
Liver Hyperplasia/Hyperproliferation	liver adenoma	liver adenoma	1.00E00	 	 	 	 	CBX7,MTOR,GLUL,CYP1B1	4	
Renal Inflammation, Renal Nephritis	lupus nephritis	lupus nephritis	1.00E00	 	 	 	 	CXCL16,FYN,VCAM1,MTOR,PSMB5,C5AR1,PSMB2,IMPDH2,LYN,FKBP1A,CD86,PTGS2	12	
Congenital Heart Anomaly	syndromic congenital heart disease	syndromic congenital heart disease	1.00E00	 	 	 	 	COL1A2,SH3PXD2B,NAA10	3	

Regulator Effects for My Projects->David Bulger->P1
Consistency Score	Node Total	Regulator Total	Regulators	Target Total	Target Molecules in Dataset	Disease & Function Total	Diseases & Functions	Known Regulator-Disease/Function Relationships
11.051	35	9	EPHB1,FOXL2,GNA13,MAP2K6,MAPK10,NOD2,PLA2G2A,S100A6,SELP	23	ATF3,BMP2,CCL2,CCL3,CXCL2,CXCL8,CYP1B1,EGR1,IL6,ITGAM,JUN,JUNB,LDLR,MMP2,MMP9,NFKBIA,PLA2G4A,PLAUR,PRKCD,PTGS2,SOCS3,TNFAIP3,TNFSF10	3	cell movement of smooth muscle cells,size of tumor,synthesis of nitric oxide	0% (0/27)	
6.765	31	3	FNDC5,LMNB1,T	21	AEBP1,ALCAM,ALPL,ATF4,COL1A1,CRABP1,CRIP1,CXCL12,CYP51A1,DHCR7,GPC4,HBEGF,ITGA3,KDR,LDLR,LMNA,MGP,PLIN2,SLIT3,SOX9,SPP1	7	apoptosis,cell survival,export of molecule,generation of cells,migration of tumor cell lines,organismal death,proliferation of cells	38% (8/21)	
5.669	13	4	Endothelin,EPHB1,MAPK10,PIN1	7	EDN1,IL6,JUN,JUNB,MMP2,MMP9,PTGS2	2	catabolism of protein,synthesis of nitric oxide	38% (3/8)	
5.578	21	2	let-7a-5p (and other miRNAs w/seed GAGGUAG),miR-16-5p (and other miRNAs w/seed AGCAGCA)	17	ATP6V1F,BSG,CCND3,COL3A1,GPAM,HMGA1,HMOX1,IFRD1,IGF2R,MMP9,MYC,NPR3,SLC12A2,SLC25A13,SLC7A1,SPI1,VTI1B	2	engulfment of tumor cell lines,size of body	0% (0/4)	
5.250	23	4	AGPAT2,FMR1,LDB1,MYCBP	16	ACACA,ADIPOQ,CCND2,CDK4,ELOVL6,KIT,LEP,MAP1B,MMP9,MTOR,ODC1,PCLO,PLIN1,SFRP1,SFRP2,TSC2	3	cell transformation,dysgenesis,synthesis of lipid	8% (1/12)	
4.992	64	7	ALDH2,IGF2BP1,INSIG2,L1CAM,LMNB1,SREBF2,TFEB	52	ACACA,ACLY,AEBP1,ARHGDIA,ARSA,ATF4,CLCN7,COL1A1,COL5A1,COL6A2,CRABP1,CRIP1,CTSA,CTSB,CTSD,CTSK,CXCL12,CYP51A1,DHCR7,G6PD,GBA,GCLM,GPAM,GSS,HBEGF,HEXA,IDH1,IL6,IRS2,LARGE1,LDLR,LMNA,LSS,LUM,MCOLN1,MGP,MMP2,MMP9,MTHFD2,MYC,NAGLU,NEU1,PLIN2,SERINC1,SERPINH1,SGSH,SHMT2,SLC3A2,SLC7A5,SLIT3,SQLE,TPP1	5	catabolism of protein,generation of cells,lysosomal storage disease,metabolism of membrane lipid derivative,organismal death	29% (10/35)	
4.743	14	2	mir-210,RICTOR	10	ABL1,ATP6AP1,ATP6V1B2,ATP6V1D,ATP6V1E1,ATP6V1F,CXCL12,FCER2,RPS21,SCARA3	2	endocytosis,internalization by tumor cell lines	0% (0/4)	
4.438	19	2	miR-122-5p (miRNAs w/seed GGAGUGU),NCSTN	13	ATP1A2,CD14,CD68,CTSG,ELANE,FCER1G,G6PC3,PKM,SLC7A1,SPI1,TRIB1,TTYH3,XPO6	4	engulfment of cells,immune response of cells,phagocytosis,transport of molecule	0% (0/8)	
3.889	13	2	BACH1,CYP	8	CD86,CXCR4,FTH1,GCLM,HMOX1,NQO1,SPP1,SQSTM1	3	cell viability,colorectal cancer,organismal death	0% (0/6)	
3.479	14	3	ECSIT,FBXO32,SOX2	10	CCND2,ETS2,IL6,JUN,JUNB,KDR,KLF6,NRP1,PRKCD,PTGS2	1	size of tumor	0% (0/3)	
3.402	10	2	FOXL2,PAF1	7	BIRC3,CCL3,CCL3L1,CCL3L3,CH25H,ISG20,PPP1R15A	1	replication of virus	0% (0/2)	
3.395	22	3	ATF4,MITF,PLIN5	17	APEX2,CHTF18,CTSK,FANCG,FYN,HIF1A,HMOX1,IL6,ITGA3,KIT,KLF9,LIG1,MGP,POR,PTGS2,PTX3,RAD51D	2	fertility,Growth Failure	33% (2/6)	
3.182	11	1	HSF2	8	CCT3,CCT5,CCT8,HIF1A,HSPA1A/HSPA1B,HSPA4,RELN,TXN	2	necrosis,proliferation of neuronal cells	0% (0/2)	
2.582	19	3	CUL4B,ELF3,SPI1	15	ANGPT1,AXIN2,BTK,CCND2,CSF1R,DAB2,ERBB2,FCER1G,HSPA8,IGFBP3,ITGAM,KIT,NME1,SPP1,TGFBR2	1	phosphorylation of protein	33% (1/3)	
2.345	27	3	ATP7B,GNA12,INSIG1	22	ABCG1,ACLY,APOE,CXCL8,CXCR4,CYP51A1,DHCR24,DHCR7,FOS,G6PD,GPAM,IL6,LDLR,LPIN1,LSS,MMP2,MYC,PCYT2,PTGS2,PTTG1,SCAP,SQLE	2	malignant neoplasm of endocrine gland,metabolism of membrane lipid derivative	17% (1/6)	
2.041	9	1	DCN	6	CDKN1C,DUSP1,ERBB2,FGF2,IL6,MMP9	2	cell death of colorectal cancer cell lines,seizure disorder	0% (0/2)	
1.706	31	8	ESR1,F2RL1,FOS,IL1B,KRAS,PDX1,RELA,TFEB	22	APOE,ARSA,CAV1,CD14,CD55,CLCN7,CTSA,CTSD,GBA,GLB1,GM2A,GRN,GUSB,HEXA,HYAL1,IL6,MCOLN1,NAGLU,NEU1,SGSH,SMPD1,TPP1	1	lysosomal storage disease	0% (0/8)	
1.697	50	5	26s Proteasome,ACVR1C,ATM,DMP1,GNRH	42	ADIPOQ,ALPL,ATF3,ATF5,BCL2L1,BMP2,CCL2,CDH5,CHEK2,CLCN7,CORO2B,CTGF,CTSA,CTSB,CTSD,CXCL8,DDIT3,EGR1,FOS,GADD45A,HMOX1,HSPE1,IL6,JUN,JUNB,LEP,MCOLN1,NOTCH1,PRNP,PSMB5,PTGS2,S1PR1,SGK1,SLC6A9,SMAD6,SMAD7,SPP1,SQSTM1,SRC,STAB1,TGM2,TNFSF10	3	colorectal cancer,Movement Disorders,neuromuscular disease	20% (3/15)	
1.581	13	2	ADRB,HDAC3	10	ABL1,BIRC3,CDH2,GADD45A,HMOX1,IKBKG,MYC,PHLPP1,PKD1,SQSTM1	1	protein kinase cascade	50% (1/2)	
1.508	16	1	HDAC3	11	BIRC3,CDH2,CXCL2,ENPP2,FOS,HMOX1,MMP9,MYC,NFKBIA,PHLPP1,SPP1	4	cell proliferation of breast cancer cell lines,outgrowth of cells,outgrowth of plasma membrane projections,protein kinase cascade	25% (1/4)	
1.500	7	1	EPHX2	4	HEY1,IL6,NOTCH1,VCAM1	2	development of neurons,growth of plasma membrane projections	0% (0/2)	
1.500	6	1	EIF4E	4	CAPG,HMOX1,MYC,PLAUR	1	phagocytosis of cells	0% (0/1)	
1.414	13	4	EPHX2,MAML1,NOTCH4,SERCA	8	BTG2,EFNB2,EGR1,HEY1,HEY2,IL6,JUN,NOTCH1	1	development of neurons	0% (0/4)	
1.265	13	2	Notch,TLR3	10	ADM,ATF3,CCND3,CDKN2B,FOS,HEY1,JUNB,MAP3K8,MYC,RHOB	1	transformation of fibroblast cell lines	0% (0/2)	
1.257	144	17	AKT1,ANGPT2,DACH1,EIF2AK2,F2R,F2RL1,F7,FADD,FOXO3,IL13,INSR,Nr1h,SATB1,SELPLG,SFTPA1,WNT3A,XBP1	124	ACADM,ADORA1,ADRB2,AGT,ALDH2,APOE,ARHGEF2,ATF4,ATP2A2,BCL2L1,BMP2,CAV1,CCL18,CCL2,CCND2,CD14,CD36,CD55,CD68,CD86,CDH2,CDK4,CDKN1C,CDKN2C,CFB,COMT,COPE,CORO2B,CSF3R,CST3,CTGF,CTSD,CXCL12,CXCR4,CYC1,CYP51A1,DBNL,DDIT3,DHCR7,DNAJB11,DNAJB2,DNAJC1,DPAGT1,EGR1,EGR2,ETS1,ETV5,FGF2,FKBP1A,FKBP4,FLOT1,FOS,GADD45A,GAP43,GAPDH,GDF15,GRN,GSK3B,HMOX1,HSPA1A/HSPA1B,HSPA5,HSPA8,ID3,IDH1,IDO1,IER3,IFNAR2,IL6,IMPDH2,ITGAM,JUN,JUNB,KCTD13,KDR,KIT,LEP,LY6E,MAP1B,MBP,MIF,MMP2,MMP9,MT1M,MT1X,MT2A,MYC,MYOM2,NDRG1,NGF,NME1,NOTCH1,NR4A2,PDK4,PMP22,PPP1R1B,PRNP,PTGS2,RASGRP2,RCAN1,S1PR1,SDC4,SELE,SFRP2,SGK1,SLC1A4,SOCS3,SOX9,SPP1,STUB1,SUCLA2,TEK,TFF3,TGFBR2,TGM2,THBS1,THRA,THY1,TIMP1,TRIB3,TXN,UQCRC1,VCAM1,VCAN,ZFP36	3	lysosomal storage disease,malignant neoplasm of endocrine gland,neuromuscular disease	16% (8/51)	
1.225	9	2	EPAS1,SREBF1	6	GBE1,GPAM,IGFBP3,IL6,IRS2,LEP	1	synthesis of glycogen	50% (1/2)	
1.000	6	1	KLF2	4	ADM,CXCL8,THBS1,TIMP1	1	cell movement of microvascular endothelial cells	0% (0/1)	
0.943	23	3	FOS,SYVN1,TP63	18	ACP2,ATP6AP1,AXL,CD14,CLIP1,CTSD,DAB2,FZD5,GBA,GM2A,HBEGF,HMOX1,IL6,LYN,MYC,PFN1,PRKCE,TPP1	2	engulfment of tumor cell lines,lysosomal storage disease	0% (0/6)	
0.816	61	3	CHRM1,MAP2K6,SRF	54	ACTA1,AKAP12,ATP2A2,BCL2L1,BMP2,CCL2,CD86,CDK4,CENPB,CLDN5,CTGF,CTSG,CXCL8,CXCR4,CYR61,DUSP5,EGR1,EGR2,EGR3,ETS1,EYA2,FLNA,FOS,FOSB,FST,IER2,IFIT2,IL6,ITGA1,ITGAM,JUN,JUNB,KDR,LDLR,LEPR,LMCD1,MAP4K4,MCL1,MMP2,MMP9,MYH11,MYLK,MYOM1,NCOA7,NR4A2,OSCP1,PDLIM7,PLA2G2A,PTGS2,S100A8,S100A9,SLC1A3,TNFSF10,VEGFD	4	colorectal cancer,neuromuscular disease,seizure disorder,size of tumor	25% (3/12)	
0.795	82	23	EIF2AK2,F2R,F2RL1,F7,FOXO3,GNA12,HDAC4,INSR,MAPK14,miR-21-5p (and other miRNAs w/seed AGCUUAU),MYCN,NKX2-3,Nr1h,PDX1,RB1,RELA,SFTPA1,SPP1,TAC1,TNC,WNT3A,WWOX,XBP1	57	APOE,ARHGEF2,BCL2L1,BMP2,CAV1,CCL18,CCND2,CD14,CD36,CD55,CDCA5,CDK4,CDKN2C,CTSD,CXCL16,CXCR4,ERBB2,ETS1,FCGRT,FGF2,GDF15,GRN,GUSB,HRAS,IDH1,IFNAR2,IL6,ITGA3,KDR,KIT,MME,MMP2,MMP9,MTOR,MYC,NDUFA13,NOTCH1,ODC1,PDK4,POR,PTGS2,RTN1,S1PR1,SELE,SFRP2,SOCS3,TEK,TFF3,TGFBR2,THBS1,THRA,TIMP1,TPO,TUBG1,VCAM1,VHL,ZFP36	2	lysosomal storage disease,malignant neoplasm of endocrine gland	15% (7/46)	
0.784	32	2	CUL4B,MYOCD	26	ACTA1,ATF4,ATP2A2,AXIN2,CASQ2,COL1A1,COL1A2,COL3A1,DDIT3,ECM2,FOS,HSPA9,IGFBP3,LOC102724428/SIK1,MYH11,MYLK,NKD2,NME1,PLA2G2A,PTPRB,PYGO2,RUNX1,TPM1,TSC2,VCAN,ZFP36	4	cell viability of tumor cell lines,colorectal cancer,neuromuscular disease,phosphorylation of protein	25% (2/8)	
0.772	47	2	HTT,mir-181	42	ADRBK1,AGT,AKAP12,ATF3,CBX1,COL18A1,CSF1R,CTGF,DDIT3,EGR1,FKBP4,FOS,GAP43,GPC1,GRK5,HBEGF,HMGA1,HRAS,HSPA8,JUN,JUNB,KAT2A,KLF4,KLF6,MMP2,MTOR,P2RX7,PEA15,PFN1,PLAUR,PRKCD,RARA,SGK1,SMAD7,SPP1,SQSTM1,SYN1,SYN2,TFRC,TUBB,TYRO3,VCAM1	3	formation of cytoskeleton,interphase,phosphorylation of protein	17% (1/6)	
0.524	144	10	ANXA2,DDIT3,HDAC4,JAK2,MAP2K6,Nr1h,RB1,SOX2,SPHK1,TNC	131	ABCC3,ACO2,ACTA1,AGT,AKR1C3,ALPL,ANGPTL4,APOC1,APOE,ATF3,ATF5,ATP2A2,AXIN1,AXIN2,BCL2L1,BMP6,BMPER,BTG3,C2,CAV1,CBX5,CCL2,CCND2,CD36,CD86,CDC42BPB,CDCA5,CEBPD,CHN1,CLPP,COBLL1,COL1A2,CPA4,CRABP2,CSF1R,CTGF,CXCL8,CXCR4,DCXR,DDX11,DKK3,DUSP5,EGR1,EMX2,ETV5,EVPL,FARP1,FECH,FGF2,FOS,FST,GADD45A,GADD45GIP1,GHITM,GPS2,GSK3B,HIF1A,HLA-DOA,HMOX1,HRAS,HSPA5,HSPE1,IFIT2,IGFBP3,IL6,IRX3,ITGAM,JUN,KDR,KIT,KLF4,KLF6,LDLR,LY6E,LYN,MBP,MMP2,MMP9,MT1G,MTOR,MYC,MYCN,MYH11,MYOM2,NBEA,NDUFA10,NDUFA13,NDUFB10,NLRP3,NME1,NOTCH1,NR4A2,NRP1,NTM,ODC1,PFN1,PLA2G2A,PMEPA1,POMC,PRKCD,PTGS2,PTX3,RTN1,SELE,SESN2,SFRP1,SLC11A1,SLC1A3,SOCS3,SOX17,SOX7,SRPRA,SYN1,SYN2,TET1,TF,THBS1,THY1,TIMP1,TMEM97,TNFRSF19,TNFSF10,TP53BP1,TPM1,TPO,TRIB3,TUBG1,UQCRC1,VCAM1,VEGFC,XPOT	3	colorectal cancer,malignant neoplasm of endocrine gland,neuromuscular disease	40% (12/30)	
0.354	10	1	PSEN1	8	ABCG1,APOE,ATOX1,BSG,CANX,CRYM,PTGS2,RELN	1	export of molecule	0% (0/1)	
0.192	129	20	CHRM1,DDIT3,EIF2AK2,F2RL1,F7,FOXO3,Growth hormone,HDAC4,HIC1,INSR,KDM5A,mir-122,MYC,MYOCD,PDGF BB,RB1,SFTPA1,TNC,UCP1,XBP1	108	ACADM,ACAT1,ADRB2,AHCY,ALCAM,ALDH2,ATF4,ATP13A2,ATP2A2,ATP2B1,BCL2L1,CA12,CANX,CAPNS1,CASQ2,CCL2,CD55,CD86,CDH2,CDKN1C,CHN1,COPE,CORO2B,CTGF,CYC1,CYP51A1,DHCR7,DKK3,DNAJB11,DNAJB2,DNAJC1,DUSP5,EGR1,EGR2,EMX2,FBL,FCGRT,FGF2,FKBP1A,FOS,FTH1,GADD45A,GAPDH,GFPT1,GHITM,GPS2,H3F3A/H3F3B,HMOX1,HRAS,HSPA5,ID3,ID4,IER3,IFNAR2,IL6,IMPDH2,ITGAM,JUN,JUNB,KAZN,KCNAB1,KCTD13,LAMP2,LDLR,LEP,MAP1B,MAP3K12,MBP,MCAM,MIF,MT1G,MT1M,MTOR,MYOM2,NBEA,NDRG1,NDUFA13,NGF,NME1,NR1D1,NR4A2,PDLIM7,PFKFB1,PKM,PMP22,PRNP,PSAT1,PTGS2,RRM2B,RTN1,S1PR1,SERPINA3,SGK1,SLC1A4,SOX9,SPP1,SRD5A1,SRM,SUCLA2,SYN1,SYN2,TGM2,THY1,TRIB3,TXN,UQCRC1,USP36,VCAN	1	neuromuscular disease	30% (6/20)	
0.000	95	11	CHRM1,CR1L,DACH1,DDIT3,GNRH,HDAC4,MEF2C,MYOCD,RB1,RCAN1,TNC	83	ACO2,ACTA1,ADIPOQ,ALPL,ANGPTL4,ATF3,ATF4,ATF5,ATP2A2,BTG3,CBX5,CCL2,CD36,CDCA5,CDK4,CEBPD,CLPP,COL18A1,COL1A2,COL3A1,COL5A1,COL6A1,COL6A3,COL8A1,CPA4,CTGF,CXCL8,DDX11,ECM2,EGR1,EGR2,EGR3,FGF2,FOS,FST,GADD45GIP1,HIF1A,HMOX1,HSPE1,IGFBP3,IL6,ITGAM,JUN,KCNJ2,KDR,KIT,KLF4,LOC102724428/SIK1,MBP,MMP2,MMP9,MTOR,MYC,MYH11,MYLK,MYOM1,MYOM2,NBEA,NDUFA10,NDUFB10,NR4A2,NTM,PLA2G2A,PMEPA1,POMC,PTGER4,PTGS2,PTPRB,PTX3,RTN1,SELE,SGK1,SOX7,SRPRA,TMEM97,TP53BP1,TPM1,TPO,TRIB3,TUBG1,VCAM1,VCAN,XPOT	1	colorectal cancer	73% (8/11)	
0.000	12	1	Growth hormone	9	ADRB2,EGR1,FOS,IER3,LDLR,NR1D1,SGK1,SPP1,TGFBR2	2	neuromuscular disease,receptor-mediated endocytosis	0% (0/2)	
-1.800	27	1	NFE2L2	25	ATF4,BCL2L1,CDKN2C,CTGF,CTSD,DDIT3,DHCR7,FTH1,HMOX1,IKBKG,IL6,LMNA,MMP9,PKIA,PSAT1,PSMB6,PTGS2,RAN,RELN,SERPINA3,SLC1A4,SLC6A9,SQSTM1,SYN2,TXN	1	Movement Disorders	100% (1/1)	
-2.000	38	1	CREB1	36	ADRA1A,APOE,BCL2L1,CD68,CDH2,COCH,CRYM,CYP51A1,EGR1,EGR2,FOS,FOSB,GAA,GADD45A,GAP43,HMOX1,HSPA5,IER3,IL6,JUN,JUNB,LDLR,LEP,MYC,NPTX2,NR4A2,NREP,PTGS2,RBP4,SERPINI1,SGK1,SMAD6,SQSTM1,SRD5A1,SYN2,TXN	1	Movement Disorders	100% (1/1)	
-2.214	12	1	NGF	10	ELK1,ETV5,GAP43,JUN,KIF2A,MMP2,MMP9,SHC1,TNFRSF12A,TXN	1	outgrowth of cells	100% (1/1)	
-2.214	42	1	HTT	40	AGT,AKAP12,ATF3,ATP2C1,BTG3,CANX,CAST,CSF1R,CTGF,DBNL,DKK3,DLG4,EGR1,EPB41L3,FKBP4,FOS,GAP43,GAPDH,GRK5,HRAS,IL11RA,JUN,KCNJ2,KLF9,LDLR,LOX,MTOR,P2RX7,PFN1,PLAUR,PRKCD,PTPN23,RAP1GAP,SGK1,SYN1,TM4SF1,TUBB,UCHL1,VAPA,VEGFD	1	microtubule dynamics	100% (1/1)	
-4.536	9	1	SLC13A1	7	ACLY,AKR1C3,ALDH1A1,ELOVL6,GPAM,HSPA8,MVD	1	synthesis of lipid	0% (0/1)	
-4.899	8	1	MAP4K4	6	ACACA,ACADVL,ACLY,GCDH,PIGO,PTDSS2	1	synthesis of lipid	0% (0/1)	
-4.950	10	1	TLR9	8	ATF3,DUSP1,EGR1,GADD45B,HMOX1,IL6,PTGS2,SOCS3	1	seizures	0% (0/1)	
-5.367	7	1	PROCR	5	ANGPT1,MMP9,PELI1,TEK,TJP1	1	proliferation of cells	100% (1/1)	
-5.814	7	1	FLT1	5	CANX,CAPN2,FLNA,TNIP1,VPS4A	1	catabolism of protein	0% (0/1)	
-6.500	6	1	MYC	4	ATF4,CDK4,MYCN,TSC2	1	hypoplasia of liver	0% (0/1)	
-7.000	6	1	CMKLR1	4	ADIPOQ,CCND2,CD55,LIPE	1	phosphorylation of protein	0% (0/1)	
-7.506	5	1	NPPB	3	ACAT2,LDLR,LSS	1	synthesis of lipid	0% (0/1)	
-8.083	5	1	miR-30c-5p (and other miRNAs w/seed GUAAACA)	3	IL6,NPR3,STX1A	1	export of molecule	0% (0/1)	
-8.660	5	1	MIR101	3	DUSP1,MCL1,PTGS2	1	seizures	0% (0/1)	
-8.660	5	1	TRIB3	3	DDIT3,GDF15,ID1	1	interphase	0% (0/1)	
-9.667	11	1	TCF7L2	9	BMP4,CTGF,FKBP1A,HIPK2,ID1,MAP4K4,MYC,PELI1,PKD1	1	protein kinase cascade	0% (0/1)	
-16.743	5	1	GNE	3	ASNS,DDIT3,TRIB3	1	cell death of tumor cell lines	100% (1/1)	
-21.500	6	1	ADRBK1	4	C5AR1,FOS,LHCGR,MYH11	1	apoptosis	100% (1/1)	
Networks for My Projects->David Bulger->P1
ID	Analysis	Molecules in Network	Score	Focus Molecules	Top Diseases and Functions	
1	P1	ANO2,ANO6,ARFGAP1,C1QTNF6,CCPG1,COBL,CTNS,CUEDC2,CYP26B1,ESR1,FAM102A,GCSH,HACD1,ICA1,LILRB5,MACROD1,MAP7,PUS1,RENBP,RERG,REXO4,RNF38,SCUBE2,SLC1A4,SLC35B4,THEM6,TMED2,TMED3,TMEM2,TMEM259,TMEM97,UBALD1,ZDHHC7,ZNF282,ZNF544	34	35	Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	
2	P1	ATIC,BCKDK,CCDC167,DDX28,EFL1,FAM213B,GBP4,GDPD5,GRB14,HACD3,ISLR,KIF1A,LOC102724828/MRPL23,ME2,MRPL12,MRPL38,MRPS21,MSRB1,MT1X,MTG1,NARS,PAICS,PLP2,PROCR,PUF60,RNMTL1,RTCA,S1PR1,SARS2,SLC15A3,STOM,TMEM134,TMEM39B,TRIP6,VKORC1	34	35	Cardiovascular Disease, Hematological Disease, Cardiovascular System Development and Function	
3	P1	ABI3BP,BANF1,BCL7C,C1orf21,CBX1,CCDC189,CEP164,CINP,CLUAP1,COPE,DCLK2,ENO1,EVC,GOT1,GPBAR1,GRK5,GRWD1,KANK1,KIF21A,KLHDC4,MAMDC2,MBNL3,MRTO4,NAB1,NIPSNAP1,RAB11FIP5,RNASEH2A,SHMT2,SLC25A39,TUFM,WDR81,XPO5,XXYLT1,YARS,ZNF428	34	35	Developmental Disorder, Hereditary Disorder, Neurological Disease	
4	P1	ADAP2,ADRB2,AHSA1,APRT,B9D1,CIAPIN1,CRAT,DNA-directed DNA polymerase,FAM162A,GALNT15,GFM1,HGH1,KCTD10,KCTD13,MTHFD1L,NPIPA8 (includes others),PAM16,POLA2,POLD1,POLD2,POLN,PTGES2,SPSB2,SRPX,SYT11,TARS2,TCTN1,TIMM44,TOMM34,TOMM40,TPPP3,TRIT1,TTC1,TTC4,ZMYND19	32	34	Metabolic Disease, Developmental Disorder, Hereditary Disorder	
5	P1	APTX,C4BPB,C9orf142,CHD1L,FAM127A,FAM127B,FAR2,FRMD4A,HBEGF,HEATR1,HIST2H2AA3/HIST2H2AA4,KLHDC3,LIG3,MTFP1,MYO1D,PARP2,PDK4,PEG10,PSMB,PSMB2,PSMB5,PSMB6,PSME4,PTMS,RABL6,RAD23A,RNF181,SH3BP4,SLC25A15,SLC7A2,TSSC1,TXNL1,VPS52,VSIG4,ZHX2	32	34	DNA Replication, Recombination, and Repair, Metabolic Disease, Amino Acid Metabolism	
6	P1	ABHD4,B3GALT6,BOD1,C6orf136,CEBPD,CSNK2B,CYB5A,CYP,DRAP1,EGR3,EIF2S2,GCLM,HDC,HDGF,HIST1H1C,INO80B,KANSL3,MAF,MAPKAPK2,MCRS1,NCLN,NOMO1 (includes others),PLS3,PPP1R3F,RCCD1,RCL1,RET,RILPL1,RNF126,RP9,SMO,SOX9,TCTEX1D2,TNFRSF14,WDR5	32	34	Tissue Development, Cell Morphology, Cellular Assembly and Organization	
7	P1	ATG7,BHLHE22,CYGB,EBF2,FAM129A,FLCN,FRYL,FUBP3,GMPPA,GPX7,IRF2BP1,IRF2BP2,IRF2BPL,KDELR3,KIAA0930,LGMN,NENF,NTM,P38 MAPK,PATL1,PDIA5,PERP,QPRT,RAB3IL1,RAVER2,RGS5,SATB2,SDF2L1,SELM,SUGP2,SUPV3L1,UROS,VARS,ZMAT3,catalase	30	33	Cancer, Organismal Injury and Abnormalities, Nervous System Development and Function	
8	P1	AES,ASS1,C5AR1,CD14,CD55,CEP170B,CFB,COL15A1,COL8A1,CREB5,DGCR6/LOC102724770,DPYSL4,EFEMP2,ELN,EVA1B,GJB2,HEYL,KLF2,LDL-cholesterol,LRRC41,MT2A,NEURL4,PGLS,PLSCR4,PTGDS,RARRES3,RBPMS,SGTA,SLCO2A1,SMUG1,THBD,TXNDC12,VAC14,VitaminD3-VDR-RXR,WSB2	30	33	Carbohydrate Metabolism, Lipid Metabolism, Small Molecule Biochemistry	
9	P1	60S ribosomal subunit,BOP1,C15orf39,C7orf50,C9orf114,C9orf9,CAPRIN1,CCDC184,CCDC86,CHDH,CTPS1,DDX24,EBNA1BP2,ERGIC1,G3BP2,GBE1,HIF1A,MRPS24,NOC3L,NOP2,PGD,PTCD1,RPL14,RPL34,RPL39L,RPL6,RPL7L1,RPL8,RPL9,RPLP0,RPLP1,SF3B5,SRPK3,THAP7,VHL-Cul2-Elongin-RBX1	30	33	Cancer, Cell Death and Survival, Organismal Injury and Abnormalities	
10	P1	AGL,ATP13A2,AXL,BNIP3L,C4orf19,CCT3,CCT5,CCT8,CDC20,DKC1,DPCD,GABAR-A,GABARAP,GABARAPL1,GNRH,HDDC3,MAP1A,MAP1B,NAP1L4,NHP2,NPM3,POC1A,RASSF5,RPAP3,RUVBL1,SLC2A3,STK24,STRN4,TNIP1,TSPAN14,TTLL4,TUBA1C,TYRO3,VAPA,WDR83OS	30	33	Cellular Assembly and Organization, Cell-To-Cell Signaling and Interaction, Reproductive System Development and Function	
11	P1	ACTG2,ADCK4,AEN,ALG3,CHFR,COX17,DYM,EMD,ENPP4,EVPL,FADS3,HS2ST1,Inflammasome (Nalp1, Asc, Casp1, Casp4),KAZN,KIF2A,LPAR1,MBOAT7,MCM2,MFSD5,NCAPH2,NEO1,NOL3,P2RX4,PIGU,PNKD,PSAT1,RRP1,SCO1,SLC25A13,SMARCB1,SOX7,SPPL2B,Sox,TACC2,TSPAN17	30	33	Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder	
12	P1	AARS2,Adaptor protein 2,BRI3,Beta Arrestin,CCDC8,CNDP2,CNOT10,DDX3X,EEF1G,FBL,GADD45A,HNRNPH1,HNRNPK,IGSF10,KPNA2,LIMA1,MGMT,MNDA,NCDN,NCL,NDRG1,PRMT1,RAE1,RNY1,RPA1,RPS6KB2,RUNDC3B,SF3A2,SF3B3,STOML2,TCEA1,TFRC,TOB1,TRAP1,ZDHHC1	30	33	Cell Cycle, Cell Death and Survival, Cell Morphology	
13	P1	ADM2,AGAP3,ATP2C1,CMTM4,COBLL1,CST3,CSTA,CSTB,CTSH,ELOVL3,Esr1-Estrogen-Sp1,FARS2,FLRT1,FLRT2,FOLR2,FOS,GAMT,GKN1,MPZL2,MRPL2,MT1A,NPTX2,NPTXR,OCIAD2,RBM6,RFNG,RTKN,Sos,TAX1BP3,TIPARP,TLN2,TMEM100,TMEM79,TNMD,ornithine decarboxylase	28	32	Cell Death and Survival, Cellular Compromise, Neurological Disease	
14	P1	AQP11,Ant,CNFN,COA3,COX15,COX7A2L,CTDSPL,DNPH1,FARP1,IMPA2,KLHL5,LDH (family),LDHD,MICALL2,MIPEP,MRPL14,MRPL40,MRPL48,MYC,NEK11,PNCK,PPI,RARRES1,SEPHS2,SFXN4,SLC25A19,SLC25A6,SLC38A1,SURF1,TACO1,TIMM10,TIMM17B,TIMM23,TMEM223,TOMM40L	28	32	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
15	P1	ADGRA2,ADGRB2,ADGRF5,ADGRG1,ADGRG2,ADGRL1,ADGRL4,APLNR,CALCRL,CMKLR1,FPR3,FZD5,FZD7,FZD9,GNG5,GPR1,GPR137,GPR146,GPR160,GPR180,GPR4,GPRC5C,Girk,Gpcr,HCAR1,HCAR2,HCAR3,LPAR5,NPY5R,PI3Kγ,PTGFR,RAMP2,RAMP3,SLC31A2,SLC52A2	28	32	Cell Signaling, Nucleic Acid Metabolism, Small Molecule Biochemistry	
16	P1	AADAC,ABHD5,COMMD1,COMMD4,COMMD9,DCLK1,EXOSC4,EXOSC5,FAM45A,FAT1,GALNT13,GNG10,GNG11,GSDMC,LIPG,LMO4,MIR101,MS4A2,NDST2,NEK7,NUCB2,PALMD,PPRC1,PTGS2,SCNN1D,SKIV2L,SPX,ST6GALNAC3,TINAGL1,TM6SF1,TMEM8B,TSEN15,TSEN54,carboxylic ester hydrolase,triacylglycerol lipase	28	32	Lipid Metabolism, Small Molecule Biochemistry, Reproductive System Development and Function	
17	P1	ARSA,ARSD,ASGR1,Aryl Sulfatase,CASQ2,CD276,CLEC4G,Collagen Type XI,DCTD,EPB41L4B,GTF3A,GTPBP6,ICT1,MALSU1,MMP9,MRPL15,MRPL17,MRPL22,MRPL24,MRPL27,MRPL37,MRPL4,MRPL43,MRPL51,MRPL55,NGRN,PLOD3,RPUSD3,SLC39A8,SMAD1/5,SULF1,SULF2,TMBIM1,WBP2,WDR12	28	32	Carbohydrate Metabolism, Small Molecule Biochemistry, Cardiovascular Disease	
18	P1	ACOT7,AHNAK,Beta ark,C11orf68,CA12,CA3,CA4,CA5B,CARS,Carbonic anhydrase,DCAKD,FAM65B,GABRE,GOT2,GRAMD1A,HMBS,KIAA0922,MAFG,MCOLN3,MICALL1,MYOF,NUP93,PACSIN3,PIDD1,PIGO,PLC,PTRH1,RCN1,SLC47A1,TECR,TMEM177,TPR,UPK3BL,YME1L1,ZP3	28	32	Neurological Disease, Metabolic Disease, Organismal Injury and Abnormalities	
19	P1	AARS,ADRBK1,AKAP12,AUP1,BRF2,CBX4,CBX6,CCNB1IP1,CLMN,CYC1,Cytochrome bc1,DDOST,FHL1,H3F3A/H3F3B,HSD17B11,IGF2BP2,IPO4,Mitochondrial complex 1,PCMTD2,PEBP1,PHLDA3,RFXANK,RNF185,RPN2,SMAP1,SMOC2,SOGA1,TMED1,TMEM147,UBL4A,UHRF1BP1,UQCC3,UQCR10,UQCRC1,chymotrypsin	28	32	Connective Tissue Disorders, Dental Disease, Developmental Disorder	
20	P1	ACTA1,ASNS,ATG101,Alpha actin,CNN1,DMAP1,ERP29,GPX3,H2AF,H2AFY2,H2AFZ,HRAS,LONP2,LRSAM1,LSP1,MGAT4B,MIB2,MYL3,PARP10,PHF23,PLOD1,PMEPA1,PRSS23,SCRIB,SORBS1,SPON1,TARS,TENM3,TIP60,TMEM222,TOX2,TPO,TSPAN6,WDR41,ZNHIT1	28	32	Cancer, Organismal Injury and Abnormalities, Endocrine System Disorders	
21	P1	C1QBP,CERS6,CHCHD4,CS,CYP1B1,GLOD4,GLRX2,LEP,LONP1,LRPPRC,LZTR1,MAOA,MED16,MED20,MED22,MED24,MED30,MED9,NADH dehydrogenase,NDUFA13,NDUFA7,NDUFA9,NDUFAB1,NDUFB10,NDUFB9,NDUFS3,NDUFS7,NDUFS8,NDUFV1,NKD2,OPLAH,PNRC2,THRA,TRAP/Media,cytochrome-c oxidase	28	32	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
22	P1	ACP2,ACP5,ACP6,ARPC5L,ASB1,C1QB,CDCA5,CIZ1,EGFL6,ERK,FAM189B,FNDC5,HMGCL,METAP2,MS4A7,NSMF,OSBPL10,P3H3,P3H4,PDGFD,PTS,RHBDD3,RNF24,S100,S100A1,S100A16,S100P,SLC35F6,THAP10,TTLL3,UQCRH,ZER1,ZNHIT2,acid phosphatase,adrenoceptor	26	31	Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Cell Cycle	
23	P1	ADSL,APOBEC3C,CCL2,CCL3L1,COPS3,COPS7A,COPS7B,COPS8,CSN1S1,DCAF10,DCAF4,DDA1,DEAF1,EIF5,ETS,ETS2,ETV5,FAM58A,GARS,GPS1,GTPBP2,HRSP12,LY96,Lymphotoxin,MFAP4,NfkB-RelA,PDDC1,SFTPD,SLC11A1,SRM,STK40,TRIB1,TRIB3,TRPC4AP,elastase	26	31	Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder	
24	P1	AIMP2,C9orf24,CDK20,DOK5,DUS2,EEF1E1,EPRS,FA,FAAP100,FAAP20,FANCE,FANCG,FLAD1,FNIP2,HARS2,IARS,ICK,LAMTOR2,LARS,LIMCH1,LMO3,MARS,MTORC1,NAGK,NTPCR,PLEKHO2,PSMA,RNA polymerase I,RNA28S5,RRAGC,RRAGD,RTN1,SDCBP,SESN2,TAF1C	26	31	Auditory Disease, Developmental Disorder, Endocrine System Disorders	
25	P1	ADRA1B,ATF3,ATF4,ATF6,Atf,CCDC106,CD24,CHAC1,Calbindin,DBP,DCAF13,DDIT3,DUSP5,FLOT1,GDF15,GOT,MEG3,MEGF9,MIR124,NUPR1,PPP1R15A,PTOV1,RALA,RCOR2,SLC15A4,SLC22A5,SLC35B1,SLC7A5,SRXN1,STX11,TENM4,TNFRSF10B,TRIM69,TUFT1,WARS	26	31	Cancer, Cell Morphology, Cellular Function and Maintenance	

My Lists for My Projects->David Bulger->P1
My Lists	 -log(p-value)	Ratio	Molecules 

Tox Lists for My Projects->David Bulger->P1
Ingenuity Toxicity Lists	 -log(p-value)	Ratio	Molecules 
Renal Necrosis/Cell Death	7.13E00	2.32E-01	GFPT1,CTGF,DPYD,HRAS,MST1,C1QA,APRT,SGPL1,ZHX2,ABCC1,MCOLN3,CAV1,HIPK2,MCL1,PTGIS,ATG7,COMP,TNFRSF10B,HBEGF,IER3,HAX1,PPP1R15A,GAPDH,TFRC,ITGA1,SFRP1,mir-21,APOE,FYN,DDIT3,GSTM5,FGF2,CEBPD,HYOU1,TNFSF10,CASP4,ANXA5,DAP3,PRKCE,RASSF5,ADORA1,NDUFAB1,ATN1,RAD21,PLAT,EMP3,TRIB3,SRXN1,PLA2G4A,FOS,MYOC,NTRK3,LYN,PEA15,BNIP3L,MAP3K8,PTGS2,ABCC3,RFXANK,ADRBK1,FAT1,CA4,HSPA1A/HSPA1B,UNC5B,HSPA5,MYC,IKBKG,NEO1,GSK3B,RET,BIRC3,HK1,TJP2,SPP1,ATF3,UNC13B,GNG2,PAWR,PTGDS,BCL2L1,NOL3,PKD1,TRIM39,DUSP1,PRKCD,IGFBP3,IDO1,ALDH3B1,ESR1,RBP4,ERN1,TNFAIP3,ATF6,HIF1A,IRF3,HMOX1,NFKBIA,EDN1,THBS1,STUB1,RPS6KB2,ERBB2,ATP13A2,PRNP,AGT,PARVA,NLRP3,AQP11,SMAD7,LRRK2,PRMT1,EMP1,SLK,PMP22,CAT,TNFRSF19,SLC47A1,P2RX7
Acute Renal Failure Panel (Rat)	6.24E00	4.03E-01	AKAP12,ADM,VCAM1,ATF3,EGR1,GDF15,HSPA1A/HSPA1B,CXCL12,FKBP1A,IL6,TUBB,TNFRSF12A,MYO5A,MYC,FOS,COL1A1,HMOX1,JUN,CD68,ANXA3,TAGLN,CD14,CXCL2,COL18A1,COL3A1
Cardiac Hypertrophy	5.85E00	2.29E-01	KCND2,CTGF,APOB,BMP4,CACNA1H,HRAS,IL6,SLC9A1,ATP2A2,NR4A3,GAA,CAV1,PNKD,HEY2,TXN,CASQ2,HADHA,MYL3,CMKLR1,NAB1,GUCY1A3,HBEGF,GRK5,MMP2,HMGA1,IER3,CTSB,MAP2K3,MAPK7,mir-21,ADM,APOE,ADAM17,FHL1,LEPR,FGF2,GNA11,GDF15,ADIPOQ,FKBP1A,H2AFZ,EIF4EBP1,DUSP5,MTOR,JUN,PRKCE,ADORA1,PLAT,ANGPT1,IGF2R,PLA2G4A,PTGS2,ADRA1A,PFN1,PFKFB1,CD36,CXCL12,TPM1,GPX3,CTSD,PLCE1,CAMK2D,MYOM1,ACTG2,GSK3B,ELN,MIF,NOX4,ATF3,KLF4,LMCD1,ADRA2A,DUSP1,PRKCD,ESR1,MAP2K5,RBP4,LEP,TNFAIP3,HIF1A,SHC1,HMOX1,NFKBIA,RGS5,EDN1,TIMP1,AGT,ADRB2,RNLS,EPAS1,P2RX4,SMAD7,RCAN1,ADGRG1,PBX3,VAV3,EDNRA,RCAN2,MMP9
Persistent Renal Ischemia-Reperfusion Injury (Mouse)	5.36E00	5E-01	SOCS3,LOX,VCAM1,LTBP2,C1QC,C1QB,GPNMB,COL1A1,LYZ,EDN1,CCL2,MGP,SOX9,CXCL2,COL3A1
Liver Necrosis/Cell Death	4.17E00	2.3E-01	SOCS3,ADRBK1,HRAS,IL6,TAF10,MYC,IKBKG,TNIP1,GSK3B,LTBR,BIRC3,HADHA,MCL1,SELE,HBEGF,IER3,BCL2L1,ERCC1,CTSB,RGN,CD14,ESR1,MME,ADM,SPTBN1,APOE,GADD45B,DDIT3,ABL1,ADIPOQ,TNFSF10,FKBP1A,SMPD1,IRF3,NGF,SLC19A3,HMOX1,ALDH2,SHC1,MTOR,NFKBIA,JUN,TIMP1,FLNA,SAA1,NCL,RHBDD3,FAAH,SLC20A1,MYCN,TYROBP,NFE2L1,FAIM,RBCK1,FOS,LAMP2,LDLR,KRT8,CBS/CBSL,BMF,SERPINH1,CAT,MAP3K8,PTGS2,DNM1L,MMP9
Oxidative Stress	4.09E00	3.51E-01	GSTM1,VCAM1,PRDX5,GSTM3,GLRX2,NQO1,IL6,ME1,GSS,NFE2L1,GSR,FOS,GPX3,JUN,GSTM2,S100A9,DUSP1,CAT,GCLM,TXNRD2
NRF2-mediated Oxidative Stress Response	3.89E00	2.36E-01	DNAJB4,MAF,HRAS,DNAJC15,DNAJB2,CLPP,GSTM2,MAP2K2,ABCC1,KEAP1,DNAJA3,ATF4,ACTG2,GSK3B,TXN,GCLM,ACTA1,PIK3C2B,GSTM3,JUNB,TXNRD1,GSR,ERP29,PRKCD,STIP1,MAP2K3,SQSTM1,DNAJB6,MAPK7,HACD3,MAP2K5,FTH1,EPHX1,GSTM5,NQO2,GSTT1,MAFG,HMOX1,JUN,DNAJC4,PRKCE,FMO1,PIK3R2,CYP2R1,GSTM1,NQO1,DNAJC1,FOS,RRAS2,DNAJB11,CAT,CDC34,AOX1,GSTO2,CYP2C8
Hepatic Fibrosis	3.8E00	2.87E-01	IGFBP4,LTBP2,LEP,FGF2,IL6,COL5A1,COL1A2,TGFBR2,CCL2,EDN1,TIMP1,THBS1,LUM,AGT,ELN,CXCL8,IGFBP6,SPP1,SMAD7,MMP2,COL1A1,XYLT2,COL6A3,IGFBP3,SPARC,CXCL2,MMP9,mir-21,COL3A1
Fatty Acid Metabolism	3.33E00	2.65E-01	ALDH4A1,ACAT2,SRD5A1,ADH1C,GCDH,ALDH2,ALDH1A1,ALDH1A3,ALDH3A2,ACSL4,CYP4X1,ALDH3A1,ACADM,CYP51A1,ALDH5A1,HADHA,ALDH1B1,ACSL3,CYP1B1,ECI1,ACAD11,ACADVL,DHRS9,CYP4B1,ALDH1A2,ACAT1,SLC27A1,IVD,CYP4F11,ADHFE1,CYP2C8
Cardiac Necrosis/Cell Death	3.19E00	2.19E-01	SOCS3,CTSG,IL6,IKBKG,CAMK2D,SPTLC2,PLA2G5,GSK3B,HADHA,MCL1,HK1,NOX4,CALCRL,SPP1,MMP2,THBD,PKN1,BCL2L1,NOL3,PRKCD,PPP1R15A,RTN4,GAPDH,MAP2K3,MDK,CYR61,mir-21,MAP2K5,ADM,SFRP2,LEP,FGF2,LEPR,ADIPOQ,TNFAIP3,HIF1A,IRAK1,HMOX1,EDN1,TIMP1,HSPE1,NCL,MAPKAPK2,ABCC9,ADRB2,AGT,PLAT,S100A1,THBS4,ANGPT1,CXCR4,CSK,MT1A,CAT,BNIP3L,PIN1,SGCD,ADRA1A,MAOA
Cardiac Fibrosis	2.91E00	2.28E-01	APOE,PFKFB1,RRM2B,CACNA1H,TNFAIP3,HRAS,PPP1CB,IRF3,ATP2A2,HMOX1,DTNA,RGS5,TIMP1,PNKD,CAV1,GSK3B,HEY2,ADORA1,ACADM,ADRB2,PLAT,AGT,ETS1,PTX3,NOX4,ATF3,SPP1,NLRP3,SGCG,EGR1,LMNA,HBEGF,SGCB,PLA2G2A,NOL3,CAPNS1,ADRA2A,LIMS1,VAV3,TSC22D1,PTGS2,SGCD,MMP9,mir-21
Liver Proliferation	2.83E00	2.19E-01	SOCS3,BMP4,CTGF,CXCL12,MST1,HRAS,IL6,GPC3,ODC1,MYC,TGFBR2,CCND3,RARA,CXCL14,SMARCB1,CAV1,ATF4,SLC7A5,GSK3B,SPP1,FST,HBEGF,ERCC1,CTSB,MDK,mir-21,SPTBN1,LEP,LEPR,ADIPOQ,SMPD1,TNFRSF12A,JUN,NFKBIA,EDN1,THBS1,TIMP1,SULF2,AGT,SLC20A1,CXCR4,SMAD7,TOB1,COL1A1,FOS,CBS/CBSL,TF,SERPINH1,EDNRA,PTGS2
Increases Cardiac Proliferation	2.73E00	3.19E-01	MYCN,LEP,FGF2,ADIPOQ,HBEGF,IL6,AKIP1,HMOX1,PLCE1,EDN1,RARA,GNL3,HEY2,MAP2K5,AGT
Primary Glomerulonephritis Biomarker Panel (Human)	2.66E00	5.45E-01	COL1A1,EGR1,HBEGF,IER3,SAMD4A,MCL1
Decreases Depolarization of Mitochondria and Mitochondrial Membrane	2.64E00	3.85E-01	COL1A1,PLA2G4A,ABCC1,CAT,HSPA1A/HSPA1B,SH3GLB1,ATP2A2,PPAN,CSTB,MCL1
Mitochondrial Dysfunction	2.42E00	2.22E-01	ATP5G1,NDUFA9,ATP5D,NDUFA7,PRDX5,UQCRH,ACO2,COX8A,NCSTN,NDUFB10,NDUFB9,NDUFA10,NDUFAB1,ATP5I,NDUFV1,COX17,UCP2,NDUFS7,GLRX2,SURF1,COX7A2L,LRRK2,NDUFAF2,GPX7,NDUFA13,GSR,VPS9D1,NDUFS8,UQCR10,CAT,CYC1,CYB5A,ATPAF2,BACE2,UQCRC1,NDUFS3,TXNRD2,MAOA,COX15
Cholesterol Biosynthesis	2.34E00	4.38E-01	MVD,SQLE,DHCR7,ACAT2,ACAT1,LSS,HMGCS1
Increases Liver Steatosis	2.34E00	2.53E-01	APOE,GPS2,CD36,UPP1,CIDEC,RGS16,RGCC,ADIPOQ,ABCG1,CCDC3,PNRC2,PSME3,ID1,HMOX1,LPIN1,DUSP1,PLIN2,CAV1,HIF1AN,CD14,ATF4,LBP,KLF2
LXR/RXR Activation	2.33E00	2.36E-01	APOE,APOB,CD36,ARG2,ABCG1,IRF3,IL6,LYZ,CCL2,SAA1,S100A8,LBP,CYP51A1,AGT,SAA2,SAA4,IL18RAP,LY96,LDLR,TF,ORM1,APOC1,CD14,ORM2,ACACA,PTGS2,PLTP,MMP9,RBP4
Increases Glomerular Injury	2.21E00	2.5E-01	ADM,CCR1,SRC,NOX4,MIF,GFPT1,CTGF,BMP4,ATF3,FGF2,SMAD7,MST1,SLK,EDN1,PRKCD,NUPR1,CFB,SPARC,ITGA1,PTGS2,mir-21,AGT
Long-term Renal Injury Pro-oxidative Response Panel (Rat)	2.2E00	4.62E-01	FMO3,NOX4,FMO2,CYBA,FMO1,FMO4
Genes associated with Chronic Allograft Nephropathy (Human)	2.18E00	3.81E-01	VCAM1,CCL2,THBS1,TIMP1,MMP2,CD163,MMP9,COL3A1
Aryl Hydrocarbon Receptor Signaling	2.14E00	2.19E-01	ALDH4A1,NFIX,GSTM5,NQO2,CDK4,IL6,GSTT1,TGM2,MYC,CTSD,NCOA7,ALDH1A1,GSTM2,JUN,CCND3,ALDH1A3,RARA,ALDH3A2,ALDH3A1,ALDH5A1,CHEK2,ALDH1B1,GSTM1,SRC,GSTM3,NQO1,CYP1B1,FOS,CCND2,ALDH1A2,ALDH3B1,HSPB7,GSTO2,ESR1,CYP2C8
Nongenotoxic Hepatocarcinogenicity Biomarker Panel	2.04E00	3.64E-01	LITAF,ALDH1A1,LOC102724788/PRODH,ICA1,MGMT,BTG2,CES2,GPR146
Increases Depolarization of Mitochondria and Mitochondrial Membrane	2.01E00	3.89E-01	TGM2,PEBP1,GZMH,BTG2,TNFSF10,CYR61,PRNP
Long-term Renal Injury Anti-oxidative Response Panel (Rat)	2.01E00	3.89E-01	HMOX1,GSTM2,CBS/CBSL,GSTM5,CAT,GCLM,GSS
Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane	1.97E00	5.71E-01	BCL2L1,KRT8,BTG2,HSPA5
Xenobiotic Metabolism Signaling	1.87E00	1.89E-01	CAMK1,AKR1C3,MAF,PPP2R3B,HRAS,IL6,CES2,CAMK2D,ALDH1A1,GSTM2,MAP2K2,KEAP1,ALDH3A2,CYP4X1,ALDH3A1,FMO4,ALDH1B1,PIK3C2B,FMO2,GSTM3,MAP3K12,PPP2R1A,DHRS9,SMOX,PTPA,PRKCD,CYP4B1,ALDH1A2,MAP2K3,ALDH3B1,MAPK7,AKR1C4,MAP2K5,EPHX1,ALDH4A1,GSTM5,NQO2,HS2ST1,ADH1C,GSTT1,HS3ST3A1,HMOX1,CES1,ALDH1A3,PRKCE,FMO1,PIK3R2,ALDH5A1,CYP51A1,GSTM1,FMO3,MGMT,NQO1,CYP1B1,RRAS2,CAT,MAP3K8,NDST2,GSTO2,ABCC3,CYP4F11,ADHFE1,MAOA,CYP2C8
Glutathione Depletion - Hepatocellular Hypertrophy	1.73E00	5E-01	POR,GSR,FMO1,ABCC3
Glutathione Depletion - CYP Induction and Reactive Metabolites	1.69E00	4.17E-01	ALDH1A1,CFB,ABCC3,GSTT1,EPHX1
Positive Acute Phase Response Proteins	1.65E00	3E-01	HMOX1,HP,SAA1,ORM2,SERPINA3,LBP,SAA2,C1QB,C2
Increases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	1.64E00	2.6E-01	BCL2L1,HSPA4,MSRB2,NOL3,PPP1R1B,FGF2,CAT,ABL1,PRKCE,TNFSF10,SERPINA3,IL6,SRXN1
Increases Renal Proliferation	1.64E00	2.1E-01	TTLL4,HRAS,MST1,IL6,MMP25,MTOR,JUN,PLCE1,EDN1,CSTF2,CD24,CDCA5,NCL,NDUFAB1,AGT,SRC,UBE2M,NINL,PLAUR,CSF1R,GRN,PPP2R1A,MYOC,SDCBP,ITGA1,TAZ,PTGS2,ESR1,P2RX7
Hepatic Stellate Cell Activation	1.64E00	2.86E-01	TGFBR2,CXCL8,CCL2,EDN1,TIMP1,TGFBR3,CD14,IL6,KLF2,AGT
p53 Signaling	1.61E00	2.22E-01	PIK3C2B,GADD45B,RRM2B,TNFRSF10B,CDK4,PERP,HIF1A,SERPINE2,BCL2L1,KAT2B,JUN,CCND2,GADD45A,THBS1,COQ8A,GNL3,PIK3R2,GSK3B,PIDD1,TRIM29,HIPK2,CHEK2
TR/RXR Activation	1.48E00	2.24E-01	PIK3C2B,UCP2,GPS2,AKR1C3,THRA,ME1,HIF1A,THRSP,KLF9,ENO1,HP,MTOR,LDLR,COL6A3,PDE3B,SLC16A2,ACACA,PIK3R2,RCAN2
Increases Renal Damage	1.41E00	2.22E-01	ADM,CCR1,MIF,BMP4,C5AR1,FGF2,RGCC,MST1,C1QA,IL6,TRIM69,THBS1,CFB,MAP2K3,MDK,mir-21,AGT,PLAT
Recovery from Ischemic Acute Renal Failure (Rat)	1.39E00	3.57E-01	COL1A1,SPP1,SGK1,TIMP1,MGP
Genes Upregulated in Response to Proteinuria-induced Oxidative Stress in Renal Proximal Tubule Cells (Human)	1.35E00	4E-01	LIG1,COMT,POLD1,GSTT1
LPS/IL-1 Mediated Inhibition of RXR Function	1.26E00	1.83E-01	ALDH4A1,APOE,GSTM5,HS2ST1,ABCG1,CES2,HS3ST3A1,GSTT1,IRAK1,ALDH1A1,GSTM2,JUN,ALDH1A3,RARA,ALDH3A2,ACSL4,FMO1,LBP,ALDH3A1,FMO4,HMGCS1,ALDH5A1,CYP2R1,GSTM1,ALDH1B1,FMO3,ACSL3,FMO2,MGMT,GSTM3,IL18RAP,LY96,SMOX,CAT,ALDH1A2,APOC1,CD14,NR5A2,ALDH3B1,SLC27A1,NDST2,PLTP,GSTO2,ABCC3,CYP2C8,MAOA
Glutathione Depletion - Phase II Reactions	1.24E00	3E-01	GSTM1,GSTM2,GSTM5,GSTM3,GSTO2,GSTT1
Cytochrome P450 Panel - Substrate is a Vitamin (Mouse)	1.17E00	4.29E-01	CYP26B1,CYP27A1,CYP2R1
Cytochrome P450 Panel - Substrate is a Vitamin (Rat)	1.17E00	4.29E-01	CYP26B1,CYP27A1,CYP2R1
RAR Activation	1.12E00	1.84E-01	AKR1C3,BMP2,ADH1C,TNIP1,JUN,ALDH1A1,KAT2B,ALDH1A3,RARA,SMARCB1,PRKCE,NR2F6,CSNK2B,PIK3R2,MAPKAPK2,SRC,DHRS3,CSK,SMAD6,SMAD7,ERCC2,CRABP1,PRMT1,FOS,DHRS9,DUSP1,PRKCD,ALDH1A2,ADCY1,IGFBP3,RDH5,RBP5,CRABP2,CARM1,RBP4
Decreases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	1.06E00	1.93E-01	MYCN,UCP2,DDIT3,FGF2,TNFRSF10B,TNFSF10,PAWR,AP2A2,LDOC1,MYC,DIABLO,TGM2,BCL2L1,SHC1,ATPIF1,ZMAT3,SLC25A6,IMMT,PRKCD,CAT,RTN4,BNIP3L,CHEK2
Increases Liver Hepatitis	1.04E00	2.18E-01	SPP1,LEP,CCL2,CCL3L3,CD14,SPARC,TNFSF10,LTBR,IL6,CYR61,SPI1,ESR1
Increases Cardiac Dysfunction	9.97E-01	2.31E-01	PTX3,TGFBR2,NOX4,ANGPTL4,CD36,FKBP1A,SLC27A1,MMP9,mir-21
Increases Liver Damage	9.36E-01	1.88E-01	FAAH,MIF,NLRP3,EGR1,SMPD1,IL6,PPOX,ALDH1A1,EDN1,BSG,SAA1,KEAP1,CTSB,CD14,MAP2K3,LBP,LTBR,PTGS2,DNM1L,ALDH3A1,MMP9,P2RX7
Cytochrome P450 Panel - Substrate is a Sterol (Human)	8.78E-01	2.86E-01	CYP11A1,CYP27A1,CYP51A1,CYP1B1
Cytochrome P450 Panel - Substrate is a Sterol (Mouse)	8.78E-01	2.86E-01	CYP11A1,CYP27A1,CYP51A1,CYP1B1
Cytochrome P450 Panel - Substrate is a Sterol (Rat)	8.78E-01	2.86E-01	CYP11A1,CYP27A1,CYP51A1,CYP1B1
Cytochrome P450 Panel - Substrate is a Fatty Acid (Human)	7.8E-01	3E-01	PTGIS,CYP4B1,CYP4F11
Anti-Apoptosis	7.68E-01	2.19E-01	TNFAIP8,BCL2L1,BIRC7,SPHK2,TNFAIP3,BIRC3,MCL1
Hypoxia-Inducible Factor Signaling	6.88E-01	1.86E-01	SHC1,JUN,EDN1,UBE2M,NQO1,HIF1AN,HRAS,ASPH,HIF1A,KDR,VHL,EIF2S2,UBE2I
Cytochrome P450 Panel - Substrate is a Vitamin (Human)	6.76E-01	3.33E-01	CYP26B1,CYP2R1
Renal Safety Biomarker Panel (PSTC)	6.76E-01	3.33E-01	TFF3,CST3
TGF-β Signaling	6.52E-01	1.78E-01	BMP4,BMP2,SMAD6,SMAD7,HRAS,INHBB,TGFBR2,FOS,JUN,RRAS2,MAP2K2,SOS1,MAP2K3,ACVR1C,AMHR2,PMEPA1
Increases Heart Failure	6.35E-01	2.17E-01	ZFPM2,CAMK2D,SLC9A1,MMP9,ADRB2
CAR/RXR Activation	6.29E-01	2.07E-01	ALDH1A1,GADD45B,CES1,ABCC3,CYP2C8,MCL1
Cell Cycle: G1/S Checkpoint Regulation	6.2E-01	1.82E-01	MYC,CCND2,CCND3,PA2G4,HDAC11,CDK4,ABL1,CDKN2C,GNL3,CDC34,GSK3B,CDKN2B
Cytochrome P450 Panel - Substrate is an Eicosanoid (Human)	5.71E-01	2.86E-01	PTGIS,CYP4F11
Irreversible Glomerulonephritis Biomarker Panel (Rat)	5.41E-01	2.31E-01	COL1A1,SPP1,NPR3
Hormone Receptor Regulated Cholesterol Metabolism	4.87E-01	2.5E-01	LDLR,ABR
Increases Permeability Transition of Mitochondria and Mitochondrial Membrane	4.87E-01	2.5E-01	TNFSF10,FAM162A
Biogenesis of Mitochondria	4.86E-01	2E-01	EPAS1,SHARPIN,DNAJA3,P2RX7
Increases Liver Hyperplasia/Hyperproliferation	4.79E-01	1.63E-01	SPTBN1,LEP,CXCR4,HRAS,IL6,GPC3,HSPA5,AKR1B10,PSME3,VCAN,ODC1,TGFBR2,MYC,JUN,PEG10,LTBR,PRNP
Renal Proximal Tubule Toxicity Biomarker Panel (Rat)	4.55E-01	1.85E-01	SPP1,TIMP1,RGN,ADORA1,GJB2
Increases Bradycardia	4.29E-01	2E-01	ADRA2A,ADORA1,AGT
Swelling of Mitochondria	4.29E-01	2E-01	BCL2L1,GZMH,PRKCE
PPARα/RXRα Activation	4.19E-01	1.55E-01	TGFBR3,CD36,GNA11,ADIPOQ,HRAS,IL6,AP2A2,TGFBR2,SHC1,IKBKG,PLCE1,NFKBIA,JUN,GNA15,MAP2K2,SOS1,CLOCK,GOT2,ACVR1C,IL18RAP,RRAS2,ADCY1,SLC27A1,MAP2K3,ADIPOR2,MED24,MAP4K4,CYP2C8
Increases Cardiac Dilation	4.19E-01	1.79E-01	TGFBR2,CAMK2D,ADORA1,MMP9,ADRB2
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARα	3.99E-01	1.58E-01	FAT1,CD36,HSPA1A/HSPA1B,HRAS,ME1,MYC,SHC1,FOS,IKBKG,JUN,NFKBIA,MAP2K2,DUSP1,SOS1,PTGS2
FXR/RXR Activation	3.37E-01	1.51E-01	APOE,APOB,SLC4A2,CYP27A1,SAA2,SAA4,G6PC3,TF,ORM1,PCK2,RARA,SAA1,APOC1,FBP1,ORM2,NR5A2,PLTP,AGT,RBP4
Protection from Hypoxia-induced Renal Ischemic Injury (Rat)	3.33E-01	2.5E-01	HMOX1
Increases Damage of Mitochondria	3.12E-01	1.82E-01	GZMH,TNFSF10
Genes Upregulated in Response to Chronic Renal Failure (Rat)	2.66E-01	2E-01	ABCC3
Reversible Glomerulonephritis Biomarker Panel (Rat)	2.5E-01	1.48E-01	SQLE,XYLT2,HNMT,IGFBP3
Cytochrome P450 Panel - Substrate is an Eicosanoid (Mouse)	2.16E-01	1.67E-01	PTGIS
Renal Inorganic Phosphate Homeostasis (Mouse)	2.16E-01	1.67E-01	ATP1A2

My Pathways for My Projects->David Bulger->P1
My Pathways	 -log(p-value)	Ratio	Molecules 

Analysis Ready Molecules for My Projects->David Bulger->P1
ID	Symbol	Expr Log Ratio
AAAS	AAAS	0.815021085171046
AADAC	AADAC	0.544616600708239
AAGAB	AAGAB	0.685794979633618
AARS	AARS	1.46216213309037
AARS2	AARS2	0.556032332496351
ABCA3	ABCA3	1.14051072065905
ABCA5	ABCA5	-0.723110538112515
ABCA8	ABCA8	-0.599441430622556
ABCB6	ABCB6	1.46023002215568
ABCC1	ABCC1	0.651896456499579
ABCC3	ABCC3	2.66055765264584
ABCC9	ABCC9	-0.7501999862847
ABCF1	ABCF1	0.537350767807
ABCG1	ABCG1	0.931203521929732
ABHD1	ABHD1	0.542924223971103
ABHD10	ABHD10	0.563673581692215
ABHD12	ABHD12	1.0866587688181
FAM108C1	ABHD17C	0.605312992164495
ABHD4	ABHD4	1.09535890672731
ABHD5	ABHD5	-0.786236586721539
ABI3BP	ABI3BP	-0.530077036779926
ABL1	ABL1	0.770343663365205
ABR	ABR	0.583466353976757
ACACA	ACACA	1.50828750523799
ACAD11	ACAD11	1.04445875195454
ACADM	ACADM	-0.510642123274959
ACADVL	ACADVL	0.52843292203758
ACAP1	ACAP1	0.533228849254383
ACAT1	ACAT1	-0.533191271373632
ACAT2	ACAT2	0.89086662240711
ACBD6	ACBD6	0.525402223084156
CCBP2	ACKR2	-0.890693781337261
ACLY	ACLY	0.945284908611883
ACO2	ACO2	0.71260170015364
ACOT4	ACOT4	1.6421567046221
ACOT7	ACOT7	1.09943991499938
ACP2	ACP2	0.551201391370704
ACP5	ACP5	0.849437695747268
ACP6	ACP6	0.733716315781784
ACRC	ACRC	0.60605862764847
ACSF2	ACSF2	0.627595160095046
ACSL3	ACSL3	1.03081776669233
ACSL4	ACSL4	-0.593915248280821
ACSM5	ACSM5	-1.84579479048584
ACTA1	ACTA1	-1.16297079851218
ACTG2	ACTG2	-1.75020484015217
ACTN1	ACTN1	0.973984664792752
ACTR1A	ACTR1A	0.69745190851483
ACVR1C	ACVR1C	-0.796910299972921
ADAM17	ADAM17	0.612451462950651
ADAM22	ADAM22	0.624349926285215
ADAMTS1	ADAMTS1	-1.36107003216827
ADAMTS18	ADAMTS18	-0.531055203984061
ADAMTS7	ADAMTS7	0.595321055219812
ADAMTSL2	ADAMTSL2	-0.627466351038365
ADAP2	ADAP2	0.59897431276317
ADCK1	ADCK1	0.755596347877498
ADCK2	ADCK2	1.05991356713697
ADCK3	ADCK3	-0.891202011163277
ADCK4	ADCK4	0.535454369115457
ADCY1	ADCY1	3.30184710231597
ADCY10P1	ADCY10P1	0.545447392178702
GPR124	ADGRA2	0.563718595190419
BAI2	ADGRB2	0.851354376775095
GPR116	ADGRF5	-0.503531830905007
GPR56	ADGRG1	-0.592691582078029
GPR64	ADGRG2	-1.08900562030583
LPHN1	ADGRL1	1.30166952983812
ELTD1	ADGRL4	-0.709005223980496
ADH1C	ADH1C	-0.618788998431452
ADHFE1	ADHFE1	-1.00177886248889
ADIPOQ	ADIPOQ	-1.66985835473034
ADIPOR2	ADIPOR2	0.574333135411901
ADM	ADM	-0.83341344000392
ADM2	ADM2	2.57290064216108
ADORA1	ADORA1	1.32529429719896
ADPGK	ADPGK	0.738007777051484
ADPRHL2	ADPRHL2	0.96480933847336
ADRA1A	ADRA1A	1.17306512736208
ADRA1B	ADRA1B	0.723716640672831
ADRA2A	ADRA2A	-2.03430961148535
ADRB2	ADRB2	-0.734382100785095
ADRBK1	ADRBK1	0.598088352778304
ADRM1	ADRM1	0.57062690234121
ADSL	ADSL	0.756982871013811
ADSSL1	ADSSL1	0.716535060885361
AEBP1	AEBP1	0.944044606349444
AEBP2	AEBP2	0.593756485043545
AEN	AEN	1.16325889318183
AES	AES	0.592522282062864
AFAP1	AFAP1	2.25676102970358
AFF3	AFF3	2.09619828567401
AFG3L2	AFG3L2	0.740100742616538
AGAP3	AGAP3	1.45669949369265
AGBL5	AGBL5	0.685555554076834
AGL	AGL	-0.583087104002037
AGT	AGT	1.38317151255851
AGTRAP	AGTRAP	0.663870330292383
AHCY	AHCY	0.694177149190367
AHCYL1	AHCYL1	0.601183010277768
AHNAK	AHNAK	0.834205204241276
AHNAK2	AHNAK2	1.79558726215922
AHSA1	AHSA1	0.509772582726555
AHSA2	AHSA2	0.529966953318005
AIDA	AIDA	0.522761924361863
AIMP2	AIMP2	1.09538571466325
AJUBA	AJUBA	0.671856239483336
AK1	AK1	0.571542880226117
AK2	AK2	0.82907854157553
AK4	AK4	-0.68836321608265
AKAP12	AKAP12	-1.03555789165737
AKIP1	AKIP1	0.706288216376183
AKR1B1	AKR1B1	1.93977683341652
AKR1B10	AKR1B10	0.829970772591517
AKR1B15	AKR1B15	0.802461566121516
AKR1C3	AKR1C3	0.555329757610543
AKR1C4	AKR1C4	0.571814154107223
ALAD	ALAD	-0.846847107329495
ALAS2	ALAS2	-0.50475095999431
ALCAM	ALCAM	0.538871803038992
ALDH1A1	ALDH1A1	-1.25009129046178
ALDH1A2	ALDH1A2	-0.770150095270225
ALDH1A3	ALDH1A3	-0.517938726427721
ALDH1B1	ALDH1B1	0.51774573007857
ALDH2	ALDH2	-0.875265110285675
ALDH3A1	ALDH3A1	0.690619749832186
ALDH3A2	ALDH3A2	1.32014377293526
ALDH3B1	ALDH3B1	1.14259673514541
ALDH4A1	ALDH4A1	0.938580991649511
ALDH5A1	ALDH5A1	0.777533220424968
ALDOA	ALDOA	0.668577353353125
ALDOC	ALDOC	-1.97117787065066
ALG1L	ALG1L	0.931267803356424
ALG3	ALG3	0.759196014854536
ALG8	ALG8	0.648494024258718
ALKBH2	ALKBH2	0.542911558286237
ALKBH3	ALKBH3	0.596685109202963
ALPK1	ALPK1	0.500771835805963
ALPL	ALPL	1.16318509705142
ALS2CL	ALS2CL	0.531314019299861
AMDHD2	AMDHD2	1.01707706318067
AMFR	AMFR	1.40440663786015
AMHR2	AMHR2	0.594302355485676
AMPH	AMPH	-0.501112518178608
AMY1A	AMY1C (includes others)	0.591597611460419
ANG	ANG	-1.10260538401531
ANGPT1	ANGPT1	-1.17216642438866
ANGPTL4	ANGPTL4	-0.669864076275946
ANGPTL5	ANGPTL5	-0.789732353099414
C19orf80	ANGPTL8	1.65129379486956
ANK2	ANK2	0.852992398782513
ANKDD1A	ANKDD1A	1.17789578242002
ANKMY1	ANKMY1	0.557020783904157
ANKRD16	ANKRD16	0.829499797855454
ANKRD20A1	ANKRD20A4 (includes others)	-0.708959393508091
ANKRD33	ANKRD33	1.33068282861566
ANKRD35	ANKRD35	0.882790539636603
ANKRD46	ANKRD46	-0.728688858362601
ANKRD54	ANKRD54	0.588609309583682
ANKRD9	ANKRD9	1.65032893385501
ANO1	ANO1	-0.655545370612535
ANO2	ANO2	-0.670794217636968
ANO3	ANO3	-1.18087944047657
ANO6	ANO6	-0.829336100145853
KAL1	ANOS1	-1.28271120158201
ANTXR1	ANTXR1	0.501246677085627
ANXA2P1	ANXA2P1	0.775774076905976
ANXA3	ANXA3	-2.87676326420297
ANXA5	ANXA5	0.511414840341787
AOC3	AOC3	-0.97079585489268
AOX1	AOX1	-0.815931802352026
AP1B1	AP1B1	0.547693431990989
AP1S2	AP1S2	-0.577993274283604
AP2A2	AP2A2	0.575963375511041
AP2M1	AP2M1	0.605119908264159
AP2S1	AP2S1	0.965728546037852
AP3B2	AP3B2	0.678402940895201
AP3D1	AP3D1	0.774835457629556
AP3M2	AP3M2	0.920648722439682
APBA3	APBA3	0.62507442310427
APBB1IP	APBB1IP	0.58208258324264
APBB3	APBB3	0.862875271787485
APCDD1	APCDD1	-0.519421900690072
APEH	APEH	1.00834334469478
APEX2	APEX2	1.17619835007488
APLNR	APLNR	0.506860499519325
APOA1BP	APOA1BP	0.818309143426211
APOB	APOB	-1.84528787654848
APOBEC3C	APOBEC3C	0.577856655079643
APOC1	APOC1	2.7367325376569
APOE	APOE	1.57277368862408
APOLD1	APOLD1	-2.3042353301365
APRT	APRT	0.685082828273845
APTX	APTX	0.840687077060898
AQP11	AQP11	1.28802088960206
AQP7P1	AQP7P1	-0.871365471136616
AQP7P2	AQP7P2	-1.11755244004189
AQP9	AQP9	-0.986591470140948
ARF5	ARF5	0.590020419409202
ARFGAP1	ARFGAP1	0.926140431219196
ARG2	ARG2	0.883480704084857
ARHGAP17	ARHGAP17	0.761008381286782
ARHGAP20	ARHGAP20	0.520253640600811
ARHGAP28	ARHGAP28	1.23765070219267
ARHGAP39	ARHGAP39	0.787792875301497
ARHGAP4	ARHGAP4	0.545487528517184
ARHGDIA	ARHGDIA	0.646122137363059
ARHGEF16	ARHGEF16	-0.515580339797021
ARHGEF2	ARHGEF2	0.824111139973893
ARHGEF35	ARHGEF35	1.51557701593065
ARHGEF4	ARHGEF4	0.936986665056854
ARHGEF5	ARHGEF5	0.91338802822228
ARHGEF6	ARHGEF6	-0.610445285758732
ARID4A	ARID4A	-0.627724134702337
ARL16	ARL16	0.601313898423988
ARL17A	ARL17A/ARL17B	-0.714724338053219
ARL2	ARL2	0.653076432930882
ARL6IP4	ARL6IP4	0.721271295611026
ARMCX1	ARMCX1	-0.501107659389658
ARPC5L	ARPC5L	0.879415694156941
C15orf38	ARPIN/C15orf38-AP3S2	0.847021801522323
C9orf37	ARRDC1-AS1	0.776678540011784
ARRDC4	ARRDC4	-0.777798758550068
ARSA	ARSA	0.736532111214312
ARSD	ARSD	0.554338427863149
AS3MT	AS3MT	0.606896015636096
ASAP3	ASAP3	1.32524481808564
ASB1	ASB1	0.572711845936605
ASCC1	ASCC1	0.565195486872072
ASCC2	ASCC2	0.61193531218084
ASGR1	ASGR1	1.42510977005796
ASIC1	ASIC1	1.02227665168009
ASIP	ASIP	0.550976046920525
ASNS	ASNS	2.04343524969916
ASPH	ASPH	0.866477740037695
ASPHD2	ASPHD2	0.547839485933701
ASPSCR1	ASPSCR1	1.0483155913654
ASS1	ASS1	0.605833925745503
ASTN2	ASTN2	0.698957621633394
ASXL2	ASXL2	-0.540929204826768
ATAD3A	ATAD3A	1.15546296602491
ATAT1	ATAT1	0.630689202021582
ATF3	ATF3	-1.95698093132671
ATF4	ATF4	0.848292913978698
ATF5	ATF5	3.40714292302033
ATF6	ATF6	0.585896235494415
C12orf44	ATG101	0.526930056717873
ATG7	ATG7	1.12030482217975
ATG9A	ATG9A	0.767295935054569
ATHL1	ATHL1	-0.894068436509691
ATIC	ATIC	0.591142122966791
ATMIN	ATMIN	0.630590513322655
ATN1	ATN1	0.785957921613225
ATOX1	ATOX1	1.10548462838221
ATP10A	ATP10A	1.52463581698544
ATP13A1	ATP13A1	0.646781237191254
ATP13A2	ATP13A2	0.753327980759265
ATP1A2	ATP1A2	-0.78268525404413
ATP2A2	ATP2A2	0.545364043502155
ATP2B1	ATP2B1	1.06520727268415
ATP2C1	ATP2C1	0.524298284945769
ATP5D	ATP5D	0.702760401228632
ATP5G1	ATP5G1	0.647843723566747
ATP5I	ATP5I	0.513386081520119
ATP6AP1	ATP6AP1	0.635007449572978
ATP6V0A2	ATP6V0A2	0.516809176384175
ATP6V0B	ATP6V0B	0.903395199307282
ATP6V1B2	ATP6V1B2	0.505551695679023
ATP6V1D	ATP6V1D	0.714314430071785
ATP6V1E1	ATP6V1E1	0.576723542859641
ATP6V1F	ATP6V1F	0.642393568614632
ATP8B4	ATP8B4	-0.598769967467142
ATPAF2	ATPAF2	0.64860973119821
ATPIF1	ATPIF1	0.515909248182238
AUP1	AUP1	0.711077548375893
AURKAIP1	AURKAIP1	0.740185906257111
AVPI1	AVPI1	-0.677065684122702
AXIN1	AXIN1	0.751738254599052
AXIN2	AXIN2	-1.04073946113915
AXL	AXL	-0.666840125495398
AZIN1	AZIN1	1.03008515557925
B3GALT6	B3GALT6	0.886361889820193
B3GAT3	B3GAT3	0.672861213282155
B4GALT2	B4GALT2	0.745476827797104
B4GALT7	B4GALT7	0.868194083389949
B9D1	B9D1	1.03157255510043
BAALC	BAALC	-0.590716402395566
BABAM1	BABAM1	0.670354408719927
BACE2	BACE2	0.593783491293166
BAIAP2L2	BAIAP2L2	0.721298854719728
BAMBI	BAMBI	2.45341116521484
BANF1	BANF1	0.638804320760047
BAP1	BAP1	0.508316326190329
BCAP29	BCAP29	0.813359825614504
BCAS4	BCAS4	1.00166237093092
BCAT2	BCAT2	0.7466691345067
BCKDK	BCKDK	0.930340760112749
BCL2L1	BCL2L1	0.716658955980947
BCL2L12	BCL2L12	0.560372986241489
BCL7C	BCL7C	0.547382696416566
BCYRN1	BCYRN1	1.14137871766213
BEX2	BEX2	0.911141181746092
BHLHE22	BHLHE22	0.793318838064393
BHLHE41	BHLHE41	1.43254494882703
BIN1	BIN1	0.983579174438709
BIRC3	BIRC3	-0.715578707868757
BIRC7	BIRC7	0.963780317976229
BLMH	BLMH	0.543292316971129
BLOC1S1	BLOC1S1	0.702267681945374
BMF	BMF	0.594769993247495
BMP2	BMP2	-0.717333490574956
BMP4	BMP4	-0.579713152422055
BMP6	BMP6	-1.59957008379222
BMPER	BMPER	1.71368868435902
BNIP3L	BNIP3L	-0.813090323336517
BOD1	BOD1	0.529494344483366
BOLA2	BOLA2/BOLA2B	0.963749746991631
BOLA3	BOLA3	0.838062864510146
BOP1	BOP1	0.988671456629986
BRE	BRE	0.695505949906073
BRF2	BRF2	0.519327366542415
BRI3	BRI3	0.772016709009022
FAM5B	BRINP2	1.26070659205226
BRMS1	BRMS1	0.634372371832915
BRSK1	BRSK1	0.501778237212139
BSCL2	BSCL2	0.845550645166484
BSG	BSG	1.18018237779715
BTG1	BTG1	-0.682343330122242
BTG2	BTG2	-2.12539901026759
BTG3	BTG3	0.600168376421367
BTK	BTK	0.729885654425841
BTNL9	BTNL9	-0.878039493713406
BUD31	BUD31	0.726247966839606
BYSL	BYSL	0.923271287383802
BZW2	BZW2	0.965948568153844
C10orf2	C10orf2	0.652116957004991
C10orf35	C10orf35	0.890150482298218
C10orf54	C10orf54	-0.67183365470233
C11orf24	C11orf24	0.681352589066325
C11orf54	C11orf54	-0.555181093117689
C11orf68	C11orf68	0.767103750174489
C11orf80	C11orf80	1.15225334429759
C12orf10	C12orf10	0.582774858239975
C12orf75	C12orf75	-0.660702742743161
C12orf76	C12orf76	0.562708101373722
C14orf180	C14orf180	-1.20883694798396
C14orf79	C14orf79	0.628599501798918
C15orf39	C15orf39	0.636780175837619
C15orf59	C15orf59	1.0648444082371
C16orf13	C16orf13	0.875807960550696
C16orf58	C16orf58	0.652917125863493
C16orf59	C16orf59	0.518860079997293
C16orf89	C16orf89	1.01458847720484
C16orf91	C16orf91	0.52113747011855
C17orf49	C17orf49	0.606792071662707
C17orf97	C17orf97	1.25628416829513
C19orf12	C19orf12	-0.693098753208161
C19orf24	C19orf24	0.927759098776929
C19orf25	C19orf25	0.520736960928711
C19orf48	C19orf48	1.25923194504872
C19orf53	C19orf53	0.643779426943598
C19orf54	C19orf54	0.6063872612814
C1GALT1C1	C1GALT1C1	-0.546684361959914
C1orf115	C1orf115	-0.712611927051368
C1orf122	C1orf122	0.5702295272028
C1orf123	C1orf123	1.0118653209808
C1orf132	C1orf132	-1.12829581976415
C1orf158	C1orf158	1.33371767335319
C1orf162	C1orf162	0.50900508273945
C1orf186	C1orf186	1.00332719869861
C1orf21	C1orf21	-0.735365391547954
C1orf216	C1orf216	0.620158933200929
C1orf54	C1orf54	0.743948161883293
C1QA	C1QA	0.74793028222733
C1QB	C1QB	1.04293137082977
C1QBP	C1QBP	0.730265395599102
C1QC	C1QC	1.02925761685016
C1QTNF1	C1QTNF1	-1.08566222375484
C1QTNF6	C1QTNF6	1.17018109001182
C1R	C1R	0.573175898767213
C2	C2	1.26725037109011
C20orf96	C20orf96	0.602711371193656
C21orf33	C21orf33/LOC102724023	0.594696948804655
C2CD4B	C2CD4B	-1.89828766865507
C2orf40	C2orf40	-0.940454011496276
C2orf88	C2orf88	1.30650891175921
C3orf18	C3orf18	0.536801915172625
C4BPB	C4BPB	1.18625487690612
C4orf19	C4orf19	-0.662813144007053
C4orf3	C4orf3	-0.851937336635728
C4orf32	C4orf32	-1.11253818269682
C5AR1	C5AR1	-0.537160844326717
C5orf15	C5orf15	0.547677662229535
C5orf28	C5orf28	0.516327122397541
C6	C6	-1.47199634107267
C6orf136	C6orf136	0.789500337177549
C6orf48	C6orf48	0.992570054754943
C7	C7	0.86775954644764
C7orf49	C7orf49	0.671601099600153
C7orf50	C7orf50	1.27221452179338
C8orf33	C8orf33	0.915909109694543
C8orf46	C8orf46	-0.597949310784114
C8orf82	C8orf82	1.06725859310201
C9orf114	C9orf114	0.846519923842276
C9orf142	C9orf142	0.857010432453078
C9orf16	C9orf16	0.729659395682891
C9orf24	C9orf24	0.626804653048386
C9orf3	C9orf3	-0.626108060876783
C9orf69	C9orf69	1.40807844187969
C9orf9	C9orf9	0.620113020455999
C9orf91	C9orf91	1.08078446948346
CA12	CA12	1.63485181114379
CA3	CA3	1.03636000495371
CA4	CA4	-1.05985999361318
CA5B	CA5B	1.36921492557292
CAAP1	CAAP1	0.673152025347826
CACHD1	CACHD1	-0.840636852236744
CACNA1H	CACNA1H	-0.806960094208965
CADM2	CADM2	-0.642181115094044
CADM3	CADM3	1.16864919925009
CADPS2	CADPS2	-0.535706660389762
CALCRL	CALCRL	-1.07603829354122
CAMK1	CAMK1	1.23098901191244
CAMK2D	CAMK2D	0.562972541043547
CANX	CANX	-0.802220717833075
CAPG	CAPG	1.55216998188492
CAPN2	CAPN2	0.542505348895739
CAPN5	CAPN5	0.949063419043062
CAPN6	CAPN6	0.643631658369678
CAPNS1	CAPNS1	0.850491499795593
CAPRIN1	CAPRIN1	0.620582548310465
CAPS	CAPS	0.646792392656108
CARD8	CARD8	-0.803782458889732
CARD9	CARD9	0.529017576190721
CARM1	CARM1	0.54268368035334
CARS	CARS	1.15870754259202
CASP4	CASP4	0.535165180606477
CASQ2	CASQ2	-0.908345359634309
CAST	CAST	-0.670119452469349
CAT	CAT	-0.505829371824655
CAV1	CAV1	-0.517042585178343
CBLN3	CBLN3	0.882251512004432
CBR3	CBR3	0.549970783568223
CBS	CBS/CBSL	1.756040306491
CBX1	CBX1	1.18512169291625
CBX4	CBX4	1.40131299391226
CBX5	CBX5	0.558123444743214
CBX6	CBX6	0.825629539390266
CBX7	CBX7	-0.543676207388111
CCDC106	CCDC106	0.513046732368771
CCDC107	CCDC107	-0.673089215749771
CCDC130	CCDC130	0.510859712161369
CCDC136	CCDC136	0.703750543538675
CCDC167	CCDC167	1.36799331522837
CCDC170	CCDC170	-0.568549572077196
CCDC178	CCDC178	-0.850714844688445
C12orf68	CCDC184	-0.509795572865358
C16orf93	CCDC189	0.60145772081073
CCDC24	CCDC24	0.950861705320737
CCDC3	CCDC3	-1.98033367221352
CCDC50	CCDC50	-0.645539891751517
CCDC68	CCDC68	-0.661837472645904
CCDC8	CCDC8	0.73756715514919
CCDC80	CCDC80	0.698183521100473
CCDC85A	CCDC85A	-0.991540409865048
CCDC86	CCDC86	0.778754733881909
CCDC88C	CCDC88C	-0.573459496414893
CCL13	CCL13	1.62507026921913
CCL18	CCL18	0.506526905991884
CCL2	CCL2	-1.7323005081177
CCL3	CCL3	-0.596484368114664
CCL3L1	CCL3L1	-0.618530639856607
CCL3L3	CCL3L3	-1.96450303825493
CCL4L2	CCL4L1/CCL4L2	-0.673491874808218
CCL8	CCL8	-1.2115442834179
CCNB1IP1	CCNB1IP1	0.65596418453705
CCND2	CCND2	0.524081346182802
CCND3	CCND3	0.845418949356453
CCNG2	CCNG2	-0.604914839297243
CCNL1	CCNL1	-1.36344368874093
CCPG1	CCPG1	1.18835501082489
CCR1	CCR1	0.501420435810507
CCT3	CCT3	0.540305418619444
CCT5	CCT5	0.58010746435986
CCT8	CCT8	0.521317124757847
CCZ1B	CCZ1/CCZ1B	0.870082045286772
CD14	CD14	1.76349577207561
CD163	CD163	1.40072457554401
CD163L1	CD163L1	0.967484572563009
CD1C	CD1C	0.613319381287124
CD209	CD209	1.70240264270859
CD24	CD24	-0.916015044112143
CD27-AS1	CD27-AS1	0.51385462334991
CD276	CD276	1.22224266276746
CD302	CD302	-0.948929475283827
CD36	CD36	-0.822998006763867
CD4	CD4	0.648352258074441
CD55	CD55	-0.534553297198667
CD59	CD59	-0.787282967357875
CD68	CD68	0.795201392836289
CD69	CD69	-1.72001899581517
CD86	CD86	0.687955854681924
CDC16	CDC16	0.59663787496464
CDC20	CDC20	0.578300646177844
CDC34	CDC34	0.85763265673239
CDC42BPB	CDC42BPB	0.662321394355615
CDC42EP2	CDC42EP2	-0.581565286315248
CDCA5	CDCA5	0.625454531491324
CDH12	CDH12	1.04409174852494
CDH2	CDH2	1.31451066182783
CDH23	CDH23	1.07090701136065
CDH5	CDH5	-0.685195838542658
CDK20	CDK20	0.722456322729647
CDK4	CDK4	0.991160016494646
CDK5RAP2	CDK5RAP2	1.07144630335261
CDKN1C	CDKN1C	-0.858691524951274
CDKN2B	CDKN2B	-0.836382640784968
CDKN2C	CDKN2C	-0.828070627590451
CDO1	CDO1	-0.746937396777823
CDRT1	CDRT1	0.578088348252212
CEBPD	CEBPD	-1.06920056373659
CEBPG	CEBPG	0.645607224820671
CECR5-AS1	CECR5-AS1	-0.642292678680217
CEL	CEL	0.682557202461557
CELF1	CELF1	1.18188625331604
CELF2	CELF2	-0.862780682028997
CENPB	CENPB	0.564814202577756
CENPBD1	CENPBD1	0.674151690091553
CENPW	CENPW	1.31891037018199
CEP104	CEP104	0.997682942659268
CEP164	CEP164	0.620839302064024
CEP170B	CEP170B	0.509802402176469
CEP89	CEP89	0.547617347259591
CERCAM	CERCAM	0.750999212598514
CERS6	CERS6	0.832041845697784
CES1	CES1	1.14222884652203
CES1P1	CES1P1	1.41562171415023
CES2	CES2	1.87457493843795
CES4A	CES4A	0.550423102023222
CFB	CFB	0.526319475127374
CFC1B	CFC1/CFC1B	0.679346556513598
CH25H	CH25H	-0.58600640094625
CHAC1	CHAC1	0.740248524712146
CHCHD10	CHCHD10	1.69716814528994
CHCHD4	CHCHD4	0.543644132287776
CHCHD5	CHCHD5	0.891686538264985
CHCHD6	CHCHD6	1.26298416506265
CHD1L	CHD1L	0.765992447158084
CHD7	CHD7	-0.688534551393961
CHDH	CHDH	0.712403967568231
CHEK2	CHEK2	0.553850307229603
CHFR	CHFR	0.577721437530407
CHI3L2	CHI3L2	1.84929658225952
CHMP1A	CHMP1A	0.745309182627223
CHN1	CHN1	-0.535770723489374
CHPF	CHPF	1.35586814659591
CHTF18	CHTF18	0.730693929844395
CHURC1	CHURC1	-1.3748221890313
CIAPIN1	CIAPIN1	0.516122389086539
C1orf51	CIART	1.17604876367591
CIDEA	CIDEA	-5.2498042074608
CIDEC	CIDEC	-0.674925228969344
CILP	CILP	0.762513111668012
CINP	CINP	0.54372920680192
CIZ1	CIZ1	0.503039922295501
CKAP4	CKAP4	0.800634065980247
CLCN3	CLCN3	0.937190208231277
CLCN7	CLCN7	1.15724186672271
CLCNKA	CLCNKA	0.818038924701341
CLDN5	CLDN5	-1.19649327073378
CLEC10A	CLEC10A	0.712708679544971
CLEC14A	CLEC14A	-0.747590356806618
CLEC16A	CLEC16A	0.561221481659216
CLEC3B	CLEC3B	-1.22238643222485
CLEC4F	CLEC4F	0.573994910817292
CLEC4G	CLEC4G	0.874714164847157
CLEC4GP1	CLEC4GP1	1.01262939637568
CLGN	CLGN	1.41299651053278
CLIP1	CLIP1	0.581882800021631
CLIP2	CLIP2	0.930938926269121
CLIP3	CLIP3	1.23478821926186
CLMN	CLMN	0.615285483125884
CLOCK	CLOCK	-0.687227719973322
CLPP	CLPP	0.578970276242516
CLPTM1	CLPTM1	0.819334869383247
CLSTN2	CLSTN2	-1.18183955558341
CLTB	CLTB	0.735606530031525
CLUAP1	CLUAP1	0.609660859557217
CMKLR1	CMKLR1	0.634896752650949
CMSS1	CMSS1	0.511309403660627
CMTM3	CMTM3	0.943662927052374
CMTM4	CMTM4	0.732344693150526
CMTM8	CMTM8	-1.01854562724107
CNDP2	CNDP2	0.664636311101955
CNFN	CNFN	1.15520211098636
CNN1	CNN1	-0.79942134293585
CNN2	CNN2	-0.622160437904857
CNOT10	CNOT10	2.21751731570376
CNPPD1	CNPPD1	0.604439681918515
CNPY4	CNPY4	0.657789925653406
COA3	COA3	0.555851547156329
COASY	COASY	0.899069176445141
COBL	COBL	-0.718087758177087
COBLL1	COBLL1	-0.537709055733607
COCH	COCH	-0.610269859730037
COG5	COG5	0.776176735756874
COL11A1	COL11A1	0.565661814696412
COL12A1	COL12A1	-0.698605648007862
COL15A1	COL15A1	0.851931134514214
COL16A1	COL16A1	1.64356850710742
COL18A1	COL18A1	0.665787326337482
COL1A1	COL1A1	2.33586126581992
COL1A2	COL1A2	1.34309583260519
COL22A1	COL22A1	0.997728668869361
COL3A1	COL3A1	0.889604422960603
COL4A5	COL4A5	0.851678554917316
COL5A1	COL5A1	1.52128123752007
COL5A2	COL5A2	1.60627240464456
COL5A3	COL5A3	1.11228449652304
COL6A1	COL6A1	1.09953637442932
COL6A2	COL6A2	1.23036530457971
COL6A3	COL6A3	0.674494140302429
COL6A6	COL6A6	1.06734148017219
COL7A1	COL7A1	0.947862682185083
COL8A1	COL8A1	-1.3351509924114
COLEC11	COLEC11	-1.24687899401349
COLEC12	COLEC12	0.553405581630546
COLGALT1	COLGALT1	0.661298497552799
COMMD1	COMMD1	0.816306587397495
COMMD4	COMMD4	0.664717440452671
COMMD9	COMMD9	0.583952494920254
COMP	COMP	-0.982377885368354
COMT	COMT	0.600725679141401
COPE	COPE	0.618278946929622
COPG2IT1	COPG2IT1	-3.07684642242345
COPS3	COPS3	0.719905598417117
COPS7A	COPS7A	0.695288734070335
COPS7B	COPS7B	0.567940854832086
COPS8	COPS8	0.845559337379985
COQ2	COQ2	1.11108501095692
COQ9	COQ9	0.574147363466938
CORO1B	CORO1B	0.565596363861923
CORO2B	CORO2B	0.54677126928805
CORO6	CORO6	1.16047013748416
CORO7	CORO7/CORO7-PAM16	0.639227449842693
COX15	COX15	0.83545808514092
COX17	COX17	0.577915610783068
COX7A2L	COX7A2L	0.660622913591637
COX8A	COX8A	0.508749321232382
CPA3	CPA3	1.19568587424802
CPA4	CPA4	1.24787294264852
CPEB1	CPEB1	1.41173329316762
CPED1	CPED1	-0.603157930999138
CPNE1	CPNE1	0.80003877867205
CPSF1	CPSF1	0.834295412693041
CPSF2	CPSF2	0.667541979228125
CPSF3	CPSF3	0.521969693395554
CPXM1	CPXM1	2.38093362569959
CPZ	CPZ	1.70121897251061
CRABP1	CRABP1	1.23447021153273
CRABP2	CRABP2	1.01469743746596
CRAT	CRAT	0.779325109243001
CREB5	CREB5	-0.951256743602322
CRHBP	CRHBP	-1.11808731342914
CRIP1	CRIP1	-0.62837251180556
CRISPLD2	CRISPLD2	-0.691827800362548
CRSP8P	CRSP8P	0.885800164932061
CRTAP	CRTAP	-0.537805559736082
CRYL1	CRYL1	0.628189610805105
CRYM	CRYM	0.619592608966299
CS	CS	0.505952358235864
CSAD	CSAD	-0.517399321388329
CSE1L	CSE1L	0.565001886156378
CSF1R	CSF1R	0.878088669664817
CSF2RA	CSF2RA	0.720895889165352
CSF3R	CSF3R	-0.975260936664452
CSK	CSK	1.06306972997285
CSN1S1	CSN1S1	-1.60053425124498
CSNK2B	CSNK2B	0.534313773672401
CSPG4	CSPG4	0.653526383842861
CSRNP1	CSRNP1	-2.2990697674614
CSRNP2	CSRNP2	0.869647604479069
CST3	CST3	0.57016122220068
CSTA	CSTA	0.736533934153355
CSTB	CSTB	0.66433304585837
CSTF2	CSTF2	0.615486762741846
CSTF3	CSTF3	0.590045962118288
CTAGE6P	CTAGE9 (includes others)	0.830638498021141
CTDNEP1	CTDNEP1	0.646569478004064
CTDSPL	CTDSPL	0.956288548921834
CTGF	CTGF	-0.868720574153658
CTHRC1	CTHRC1	1.01659293482982
CTNS	CTNS	0.967155564317237
CTPS1	CTPS1	1.45236909071991
CTSA	CTSA	0.680933374091801
CTSB	CTSB	0.5001735608506
CTSD	CTSD	1.27292069828
CTSG	CTSG	1.59790980116363
CTSH	CTSH	0.50109043155133
CTSK	CTSK	0.574674022719127
CUBN	CUBN	1.0944027773055
CUEDC1	CUEDC1	0.568568161542709
CUEDC2	CUEDC2	0.53738512471745
CUL7	CUL7	0.610463373122545
CUL9	CUL9	0.844064634120203
CUTA	CUTA	0.779614205000775
CXCL12	CXCL12	0.751237014652611
CXCL14	CXCL14	-0.842157902052091
CXCL16	CXCL16	0.683902102669575
CXCL2	CXCL2	-2.69005440764699
IL8	CXCL8	-1.95338479959227
CXCR4	CXCR4	-0.784408758902721
CXorf57	CXorf57	-0.695987282304607
CYB561	CYB561	0.588873647762168
CYB5A	CYB5A	-0.564634296006574
CYB5R1	CYB5R1	0.722375214344651
CYBA	CYBA	0.520774531586908
CYC1	CYC1	0.510355532269012
CYCSP55	CYCSP55	0.660203112135669
CYGB	CYGB	1.23762714955834
CYP11A1	CYP11A1	1.72307790350733
CYP1B1	CYP1B1	-0.937923145985552
CYP26B1	CYP26B1	-1.69031035959226
CYP27A1	CYP27A1	1.18510449158561
CYP2C8	CYP2C8	0.735315297439103
CYP2R1	CYP2R1	0.927721165156455
CYP4B1	CYP4B1	-1.04941609788393
CYP4F11	CYP4F11	2.60829969826212
CYP4F22	CYP4F22	1.1510355601404
CYP4X1	CYP4X1	-0.925051998974134
CYP51A1	CYP51A1	0.950337616952679
CYR61	CYR61	-2.75500922513849
CYSTM1	CYSTM1	0.806268091670261
CYTH3	CYTH3	-0.618045415511733
CYTIP	CYTIP	-0.915316951333526
CYYR1	CYYR1	-0.748695223823402
D2HGDH	D2HGDH	1.18894174821476
DAAM1	DAAM1	-0.514888556237753
DAAM2	DAAM2	-0.541376014844596
DAB2	DAB2	1.02095510813495
DANCR	DANCR	0.53697712158272
DAP3	DAP3	0.528947628221967
DAPK2	DAPK2	-1.0653835558246
DBNDD1	DBNDD1	0.896715856844925
DBNL	DBNL	0.525257744348033
DBP	DBP	0.916960089597466
DCAF10	DCAF10	0.796571895594327
DCAF13	DCAF13	0.592472887097479
DCAF4	DCAF4	0.567284379303115
DCAKD	DCAKD	0.797432278661194
DCHS1	DCHS1	0.607926065259898
DCLK1	DCLK1	0.60920316325085
DCLK2	DCLK2	2.53925611294388
DCTD	DCTD	0.630217706969514
DCXR	DCXR	0.647258604023208
DDA1	DDA1	0.746965731613266
DDAH2	DDAH2	0.64463102069208
DDIT3	DDIT3	2.34383304269184
DDIT4	DDIT4	1.06233156719526
DDIT4L	DDIT4L	0.770779170507636
DDOST	DDOST	0.727187869411511
DDRGK1	DDRGK1	0.626808911704219
DDT	DDT	0.574001045925804
DDX11	DDX11	0.591153443365455
DDX24	DDX24	0.659319683085496
DDX28	DDX28	0.879706114922008
DDX3X	DDX3X	-0.807559193846535
DDX41	DDX41	0.768463416071422
DDX49	DDX49	0.713203847319498
DEAF1	DEAF1	0.592598992969207
DECR2	DECR2	0.562946757002229
DEFB1	DEFB1	0.792548238227479
DEFB132	DEFB132	-1.67020341168432
DENND1A	DENND1A	0.916986825895956
DENND4B	DENND4B	0.567367191153111
DENND6B	DENND6B	0.707618214977468
DESI1	DESI1	0.903715886789017
DEXI	DEXI	0.637002880431807
DFNA5	DFNA5	2.40435173109989
DGAT2	DGAT2	0.615379114938293
DGCR5	DGCR5	1.50030174601562
DGCR6	DGCR6/LOC102724770	1.18578421128618
DGCR6L	DGCR6L	1.15536465443377
DGKQ	DGKQ	2.024363797264
DGUOK	DGUOK	0.60009771237101
DHCR24	DHCR24	0.806216579565816
DHCR7	DHCR7	1.05821520036658
DHPS	DHPS	0.537510098783764
DHRS3	DHRS3	-0.565219763137019
DHRS4	DHRS4	0.619137666328373
DHRS7B	DHRS7B	0.582404708691755
DHRS9	DHRS9	0.91879755158819
DHTKD1	DHTKD1	0.566095328534575
DHX37	DHX37	0.893250208825776
DIABLO	DIABLO	0.841100089772325
DIO3OS	DIO3OS	1.01042475280304
DIP2B	DIP2B	0.635041240030691
DIP2C	DIP2C	0.593172855893587
DIRAS1	DIRAS1	0.929137556644557
DIRC3	DIRC3	-0.806746656541158
DKC1	DKC1	0.549212122048876
DKK3	DKK3	-0.605355692511787
DLEU1	DLEU1	0.897662655056351
DLG4	DLG4	1.18436005782812
DLGAP1-AS1	DLGAP1-AS1	0.567462938836817
DLGAP4	DLGAP4	1.93003029717671
DMAP1	DMAP1	0.654914996841384
DMRT2	DMRT2	-0.853381344863299
DNAH6	DNAH6	-0.613794187403446
DNAJA3	DNAJA3	0.910332821342658
DNAJB11	DNAJB11	0.525638162909963
DNAJB2	DNAJB2	0.56949083278794
DNAJB4	DNAJB4	-0.561946309077597
DNAJB6	DNAJB6	-0.563917576072195
DNAJC1	DNAJC1	0.779084886618246
DNAJC15	DNAJC15	0.636958317681512
DNAJC4	DNAJC4	0.692930480304022
DNAL4	DNAL4	0.824719637002645
DNASE1L3	DNASE1L3	-0.601809051175976
DNASE2	DNASE2	0.720837884087379
DNM1L	DNM1L	0.566885454099417
DNPEP	DNPEP	0.556668675045933
DNPH1	DNPH1	0.843456183759216
DOCK1	DOCK1	-0.55193380155964
DOCK6	DOCK6	0.818969643965128
DOK2	DOK2	0.502945602761976
DOK5	DOK5	0.873577729111228
DPAGT1	DPAGT1	0.573052993109586
DPCD	DPCD	0.578814302558105
DPH2	DPH2	0.672644076660673
DPH5	DPH5	0.767766525537375
ATPBD4	DPH6	0.595236256445125
DPM2	DPM2	0.542333462650669
DPP7	DPP7	0.67303119219474
DPP9	DPP9	0.536160956379122
DPT	DPT	-1.30743196276264
DPYD	DPYD	-0.512447824820719
DPYSL4	DPYSL4	0.818193187259623
DRAP1	DRAP1	0.716773681324759
DRG2	DRG2	0.518287522618013
DSG2	DSG2	-1.17855870060684
DTD1	DTD1	0.637809824993002
DTNA	DTNA	0.709692050575703
DUS1L	DUS1L	0.563558889047293
DUS2L	DUS2	0.907047456664239
DUS4L	DUS4L	0.536694014331027
DUSP1	DUSP1	-2.12037072828402
DUSP10	DUSP10	0.867208055864583
DUSP14	DUSP14	0.709328173522233
DUSP22	DUSP22	-0.711983399665725
DUSP5	DUSP5	-0.808281987051001
DVL2	DVL2	0.530360885421726
DVL3	DVL3	0.535591091687862
DYM	DYM	0.688868911127153
DYNLT1	DYNLT1	0.948975859468442
EARS2	EARS2	0.727233293436932
EBF1	EBF1	-0.702482961408008
EBF2	EBF2	-0.704930722724794
EBNA1BP2	EBNA1BP2	0.80685693072279
ECHDC1	ECHDC1	-0.616230964867665
ECI1	ECI1	0.612484502596905
ECM2	ECM2	-0.860072485347712
EDEM1	EDEM1	0.885761232510424
EDF1	EDF1	0.812222261006285
EDN1	EDN1	-1.04586938676835
EDNRA	EDNRA	-0.664942419088516
EEF1E1	EEF1E1	0.540719570385112
EEF1G	EEF1G	0.573629250096864
FAM86A	EEF2KMT	0.875349900708648
EFEMP2	EFEMP2	0.666260762460397
EFHB	EFHB	0.668918883585351
EFHD1	EFHD1	-0.698048266663189
EFTUD1	EFL1	0.579738674287248
EFNB2	EFNB2	-1.29033633946476
EFR3A	EFR3A	0.525869259242995
EFS	EFS	1.1895400217431
EGFL6	EGFL6	-2.54926223956979
EGR1	EGR1	-3.66686237421693
EGR2	EGR2	-1.75039943992053
EGR3	EGR3	-0.852547192032619
EIF2AK1	EIF2AK1	0.730355914620316
EIF2S2	EIF2S2	0.720935484721531
EIF3B	EIF3B	0.724050863740583
EIF3C	EIF3C	0.609396506855194
EIF3K	EIF3K	0.503567173915945
EIF4E2	EIF4E2	0.805737708414057
EIF4EBP1	EIF4EBP1	0.847843364604
EIF4EBP2	EIF4EBP2	-0.729781638350602
EIF4EBP3	EIF4EBP3	0.741677149517464
EIF5	EIF5	-0.727207449766924
EIF6	EIF6	0.816807778098456
ELANE	ELANE	0.551918368323282
ELK1	ELK1	0.578197114643991
ELMOD3	ELMOD3	-0.890742106447136
ELN	ELN	1.0274125737587
ELOF1	ELOF1	0.641566869176086
ELOVL3	ELOVL3	-0.5286612744469
ELOVL6	ELOVL6	1.7706947312554
EMC1	EMC1	0.634563710465694
EMC6	EMC6	0.592789799433236
EMD	EMD	0.716711908904635
EMG1	EMG1	0.647609376653784
EMILIN1	EMILIN1	1.11291733194728
EMILIN2	EMILIN2	0.664550834523053
EMP1	EMP1	-1.06374892837054
EMP3	EMP3	0.567139952965259
EMX2	EMX2	0.852712012044857
EMX2OS	EMX2OS	0.742756193794665
ENAH	ENAH	0.715677865058941
ENKD1	ENKD1	0.624351767797429
ENO1	ENO1	0.686892967852369
ENPP2	ENPP2	-0.99038119836757
ENPP4	ENPP4	-0.875045637736376
ENTPD6	ENTPD6	0.768739827613514
EOGT	EOGT	-0.966286917864369
EPAS1	EPAS1	-0.737154847355026
EPB41L1	EPB41L1	0.865150478499407
EPB41L2	EPB41L2	-0.724085588558592
EPB41L3	EPB41L3	1.19405050806754
EPB41L4B	EPB41L4B	-1.14704844655433
EPB42	EPB42	-1.40444688829644
EPHB3	EPHB3	0.703031109010501
EPHB6	EPHB6	-0.571772862376806
EPHX1	EPHX1	1.44202879055195
EPN1	EPN1	0.724808503112697
EPRS	EPRS	0.86416008893458
EPS15L1	EPS15L1	0.676868921514877
ERAL1	ERAL1	0.96273210663622
ERAP2	ERAP2	-1.56148565107272
ERBB2	ERBB2	0.877066727350788
ERCC1	ERCC1	0.885957170116509
ERCC2	ERCC2	0.589876140117335
ERGIC1	ERGIC1	0.690729391608748
ERI3	ERI3	0.689838447218023
ERICH1	ERICH1	-0.708073095158653
ERN1	ERN1	0.817278913744499
ERP29	ERP29	0.707291748782899
ERV3-1	ERV3-1	0.604336633985866
ESAM	ESAM	-0.598337092176924
ESPNL	ESPNL	1.20527018442936
ESR1	ESR1	-0.549812273688844
ESRRAP2	ESRRAP2	0.564720139882749
ETS1	ETS1	-0.580585219893966
ETS2	ETS2	-0.529646959140851
ETV5	ETV5	1.47874473393998
ETV6	ETV6	0.611510353725353
EVA1B	EVA1B	0.938244586338017
EVC	EVC	1.24781888085885
EVI5L	EVI5L	1.23540162164289
EVPL	EVPL	0.626213751733027
EXOC3	EXOC3	0.626813357211205
EXOC4	EXOC4	0.506211698957092
EXOSC1	EXOSC1	0.690765494100364
EXOSC3	EXOSC3	0.526103676706922
EXOSC4	EXOSC4	0.774403519168237
EXOSC5	EXOSC5	0.677758602591662
EXOSC7	EXOSC7	1.07675579053065
EXTL3	EXTL3	0.527266891958683
EYA2	EYA2	1.43684262349441
F11R	F11R	-0.553525971883599
F13A1	F13A1	0.982522628905026
F8	F8	-0.697315200353724
FAAH	FAAH	-0.580859129329439
C17orf70	FAAP100	1.09269604890922
C1orf86	FAAP20	0.842310573481658
FADS3	FADS3	1.08985772619314
FAF1	FAF1	0.79293746611676
FAHD2A	FAHD2A	0.708558099165091
FAHD2B	FAHD2B	0.738853743541732
FAIM	FAIM	-0.648107418537826
FAM102A	FAM102A	0.672878931347317
FAM107A	FAM107A	-0.854311873495318
FAM110B	FAM110B	0.732768296646323
FAM124B	FAM124B	-0.644997321684412
FAM127A	FAM127A	0.542080977728878
FAM127B	FAM127B	0.612179251229372
FAM129A	FAM129A	2.01825483813211
FAM129B	FAM129B	0.663428305298348
FAM134A	FAM134A	0.579484914684971
FAM134B	FAM134B	0.756356462841726
FAM136A	FAM136A	0.652083000080034
FAM156A	FAM156A/FAM156B	-0.555703168889578
FAM162A	FAM162A	0.579106870428537
FAM173A	FAM173A	0.87287951939199
FAM174B	FAM174B	0.866847032565561
FAM178B	FAM178B	-1.00487685998494
FAM189B	FAM189B	0.73846118803568
FAM193A	FAM193A	0.611944608523421
FAM193B	FAM193B	0.555457798778801
FAM195B	FAM195B	1.04064530220917
FAM20B	FAM20B	0.519182265197256
FAM212A	FAM212A	0.700742763399976
FAM213B	FAM213B	0.515916452522841
FAM219B	FAM219B	0.890142096816102
ITFG3	FAM234A	0.8827467591112
FAM26F	FAM26F	0.945900808128177
FAM3A	FAM3A	0.690314400167571
FAM43A	FAM43A	0.61286469666172
FAM45A	FAM45A	0.86932938880746
FAM46A	FAM46A	0.556574372846588
FAM49A	FAM49A	0.699503422879575
FAM50B	FAM50B	0.525363241125916
FAM53B	FAM53B	0.740764717553186
FAM58A	FAM58A	0.681578688092413
FAM65B	FAM65B	-0.576942526270133
FAM71E1	FAM71E1	0.61345272166182
FAM86B1	FAM86B1	0.621263538065835
FAM86C1	FAM86C1	0.78651845415462
FAM86C2P	FAM86C2P	0.732038586465853
FAM86DP	FAM86DP	0.812927186274535
FAM86HP	FAM86HP	0.863255667429047
FAM89A	FAM89A	-0.590274823892184
FAM96B	FAM96B	0.689341343537005
FANCE	FANCE	2.30248944030384
FANCG	FANCG	0.843662206980565
FAR2	FAR2	1.03742823245762
FARP1	FARP1	0.829197950185065
FARS2	FARS2	0.636696400487663
FARSA	FARSA	0.729831775596093
FASTK	FASTK	1.02565982948075
FAT1	FAT1	0.572514728880897
C5orf4	FAXDC2	-0.544822474499527
FBL	FBL	0.589300469959011
FBN2	FBN2	0.6356129737272
FBP1	FBP1	-1.0240162337158
FBXO10	FBXO10	1.36332538065137
FBXO22	FBXO22	0.688221834103387
FBXO3	FBXO3	-0.558860230765086
FBXO45	FBXO45	0.509473147454102
FBXW5	FBXW5	1.15148108381482
FBXW9	FBXW9	0.904087361080296
FCER1A	FCER1A	0.914430686230005
FCER1G	FCER1G	0.843071616675852
FCER2	FCER2	0.764314061890374
FCGBP	FCGBP	2.40568272728399
FCGR3B	FCGR3A/FCGR3B	-0.749192087726425
FCGRT	FCGRT	0.63515646082448
FCN3	FCN3	-0.598336185246043
FCRLB	FCRLB	0.80655836734898
FDX1L	FDX1L	0.835217411167317
FECH	FECH	0.568324568927804
FEM1A	FEM1A	0.824492523156545
FERMT3	FERMT3	0.670622861811533
FGF2	FGF2	0.804443358649114
FGFBP2	FGFBP2	-1.89376319883319
FHL1	FHL1	-1.51598680936693
FIBP	FIBP	1.08080063045467
FIG4	FIG4	0.703490429410929
FIGF	FIGF	-0.577781733551279
FIZ1	FIZ1	0.521292410974764
FKBP1A	FKBP1A	0.699036475364109
FKBP2	FKBP2	0.787613207710321
FKBP4	FKBP4	0.890156290554703
FKBP9L	FKBP9P1	0.680032929625076
FLAD1	FLAD1	0.646444923757467
FLCN	FLCN	0.591818040638044
FLJ35934	FLJ35934	0.775034038771541
FLNA	FLNA	0.81037805108368
FLNC	FLNC	3.08044290884677
FLOT1	FLOT1	0.524779306977143
FLRT1	FLRT1	0.959935519283715
FLRT2	FLRT2	-0.523650290822323
FMO1	FMO1	0.891375526580366
FMO2	FMO2	-1.02369871743418
FMO3	FMO3	-1.22867751047627
FMO4	FMO4	0.587804660061203
FNDC5	FNDC5	0.780894657037768
FNIP2	FNIP2	-0.576872677303498
FNTA	FNTA	-0.690622625471604
FOLR2	FOLR2	1.31848508209942
FOS	FOS	-5.87502791494687
FOSB	FOSB	-5.41975456334533
FOXC1	FOXC1	-0.755442534791222
FOXRED1	FOXRED1	0.54885497801645
FPR3	FPR3	0.643007931445794
FRMD1	FRMD1	-0.680622857728811
FRMD3	FRMD3	-0.598611052911745
FRMD4A	FRMD4A	-0.660992603000317
FRYL	FRYL	-0.578125700853504
FRZB	FRZB	-0.717276531381526
FSCN1	FSCN1	0.892283966697368
FST	FST	1.33149230163947
FTH1	FTH1	1.26082067239264
FTH1P11	FTH1P11	1.17247124682813
FTH1P12	FTH1P12	0.504862153068782
FTH1P2	FTH1P2	1.34433538927532
FTH1P3	FTH1P3	1.1535157921215
FTH1P8	FTH1P8	0.965787940033551
FUBP3	FUBP3	-0.553382319029605
FUCA1	FUCA1	0.795756686381916
FUK	FUK	0.507719640947244
FYN	FYN	0.562813496088072
FZD2	FZD2	0.972803802034824
FZD5	FZD5	-0.616698576205202
FZD7	FZD7	0.644195175003724
FZD9	FZD9	0.560661697537335
G0S2	G0S2	0.892953996764723
G3BP2	G3BP2	-0.582255250691976
G6PC3	G6PC3	1.31514790555192
G6PD	G6PD	1.18870653422507
GAA	GAA	0.792497895910409
GABARAP	GABARAP	0.521309999134363
GABARAPL1	GABARAPL1	-0.81951357409744
GABRE	GABRE	-0.672200580143545
GADD45A	GADD45A	0.904770335745269
GADD45B	GADD45B	-1.74972974215248
GADD45GIP1	GADD45GIP1	0.629577833502829
GAGE2B	GAGE13 (includes others)	0.559437216154898
GALE	GALE	0.552434628759357
GALK1	GALK1	0.882135940819788
GALM	GALM	0.839661541045744
GALNT13	GALNT13	1.94362468366318
GALNT15	GALNT15	-0.994590070479077
GAMT	GAMT	0.784898354071636
GAP43	GAP43	0.808672343738778
GAPDH	GAPDH	1.02177089237715
GAPVD1	GAPVD1	0.513160344516812
GARS	GARS	2.16230431850978
GATAD2A	GATAD2A	0.656572972949892
GATSL3	GATSL3	0.807233810138516
GBA	GBA	0.734761909206023
GBE1	GBE1	1.16599417809533
GBP1	GBP1	-0.694643692687567
GBP4	GBP4	-0.848438939495886
GCA	GCA	-0.76538335967708
GCAT	GCAT	1.07630132064212
GCC1	GCC1	0.584685115608741
GCDH	GCDH	0.623366731579376
GCLM	GCLM	1.13006704427991
GCOM1	GCOM1	-1.18003194913707
GCSH	GCSH	0.551682602823533
GDE1	GDE1	0.786909765234693
GDF15	GDF15	3.65830292518855
GDI1	GDI1	0.751867979284794
GDPD5	GDPD5	-1.27652819148407
GFM1	GFM1	0.53469724316392
GFPT1	GFPT1	1.23711536843614
GFPT2	GFPT2	0.749476545359941
GFRA2	GFRA2	0.609417926890542
GHITM	GHITM	0.539436111948186
GIMAP5	GIMAP5	0.578142757961151
GIMAP6	GIMAP6	-0.880555674421846
GIPC1	GIPC1	0.739562436315629
GJA4	GJA4	-0.634731354139175
GJB2	GJB2	0.807166003323082
GKN1	GKN1	0.51793924430942
GLB1	GLB1	0.761236488417703
GLG1	GLG1	0.622391809579589
GLIPR2	GLIPR2	0.581591421507463
C1orf85	GLMP	0.644538160297677
GLOD4	GLOD4	0.526552506311492
GLRX	GLRX	0.565705915562982
GLRX2	GLRX2	0.753547333388382
GLUL	GLUL	-0.644864142091391
GLYAT	GLYAT	-3.09596700553175
GM2A	GM2A	0.53199923795315
GMDS	GMDS	0.672073070721542
GMPPA	GMPPA	0.761647063307614
GMPPB	GMPPB	0.715263527883628
GNA11	GNA11	0.523363340643728
GNA15	GNA15	0.554635773764934
GNAI1	GNAI1	-0.921671156675801
GNAZ	GNAZ	-0.682012830274559
GNG10	GNG10	-0.611320331572345
GNG11	GNG11	-0.540837588356939
GNG2	GNG2	0.618116227149201
GNG5	GNG5	0.59051211383687
GNL3	GNL3	1.34337201452976
GNPDA1	GNPDA1	1.12555983902989
GOLGA3	GOLGA3	0.594431905370922
GOT1	GOT1	1.73983405052897
GOT2	GOT2	0.602593630189741
GPAA1	GPAA1	1.30507212499654
GPAM	GPAM	0.55249369961738
GPBAR1	GPBAR1	-0.936423652039909
GPC1	GPC1	2.41285512551732
GPC3	GPC3	-0.566281596130312
GPC4	GPC4	0.982629530293393
GPC6	GPC6	-0.603535483713963
GPIHBP1	GPIHBP1	-1.04967420970639
GPM6B	GPM6B	-0.812177508644879
GPNMB	GPNMB	0.629772936131082
GPR1	GPR1	1.63899854784338
GPR137	GPR137	0.900057310560175
GPR146	GPR146	-0.728187343221904
GPR160	GPR160	-0.513684760903991
GPR180	GPR180	-0.664017844651643
GPR183	GPR183	-1.33300934442526
GPR34	GPR34	-1.05767257246585
GPR4	GPR4	-0.69541168848982
GPRC5C	GPRC5C	0.525222541418727
GPS1	GPS1	0.643649741505755
GPS2	GPS2	0.646573505063189
GPX3	GPX3	-0.872231877280979
GPX7	GPX7	0.786473907096232
GPX8	GPX8	0.733716552813189
GRAMD1A	GRAMD1A	0.683433105168362
GRB14	GRB14	-0.624455025623918
GRINA	GRINA	1.02973471497508
GRK5	GRK5	-0.501872444812641
GRN	GRN	0.682483856068562
GRWD1	GRWD1	0.834019753492522
PION	GSAP	0.976310987093841
GSDMB	GSDMB	-0.8998613169358
GSDMC	GSDMC	0.628740280022352
GSK3B	GSK3B	0.600518009518988
GSPT1	GSPT1	0.569661172024051
GSR	GSR	0.523732225207781
GSS	GSS	0.840536198536348
GSTM1	GSTM1	-1.13982044791794
GSTM2	GSTM2	0.645815820431114
GSTM3	GSTM3	0.718268398573565
GSTM5	GSTM5	1.02942135969917
GSTO2	GSTO2	0.885669400891391
GSTT1	GSTT1	-4.07564263155697
GTF2IRD1	GTF2IRD1	1.03139561353188
GTF3A	GTF3A	0.699827163758562
GTF3C1	GTF3C1	0.544077847648435
GTPBP2	GTPBP2	1.16151590109728
GTPBP3	GTPBP3	0.503186041333707
GTPBP6	GTPBP6	0.766578181847366
GUCD1	GUCD1	0.5967598220004
GUCY1A3	GUCY1A3	-1.10045894149137
GUF1	GUF1	0.598374370648693
GULP1	GULP1	0.590739294589023
GUSB	GUSB	0.514447221223516
GUSBP11	GUSBP11	0.761368638250632
GYG2	GYG2	-0.563169879811128
GYPE	GYPE	0.828110239725265
GYS1	GYS1	0.861919422600897
GZMH	GZMH	-0.56210127162675
H19	H19	1.07866380431889
H1F0	H1F0	0.914537421774281
H2AFY2	H2AFY2	1.04482389662036
H2AFZ	H2AFZ	0.502110042159132
H3F3B	H3F3A/H3F3B	-0.549299868835954
H6PD	H6PD	0.992378019948826
HABP4	HABP4	1.16839313839773
PTPLA	HACD1	1.53207649615898
PTPLAD1	HACD3	0.587956275207459
HADHA	HADHA	0.820824396529333
HAGH	HAGH	0.661907863172443
HARS	HARS	0.708656049528744
HARS2	HARS2	0.564900535254466
HAVCR2	HAVCR2	0.869848490608235
HAX1	HAX1	0.580688683076906
HBEGF	HBEGF	-1.35109611320677
HCAR1	HCAR1	-0.926411353464532
HCAR2	HCAR2	-0.924285908918661
HCAR3	HCAR3	-0.690517929388107
HCG9	HCG9	0.706440406556467
HCST	HCST	0.822277536216063
HDAC11	HDAC11	0.545188877173556
HDC	HDC	0.943297677104558
HDDC2	HDDC2	0.595672171598301
HDDC3	HDDC3	0.712003021496954
HDGF	HDGF	0.576930250596874
HEATR1	HEATR1	0.554673154758676
HELZ	HELZ	-0.536236522757825
HEPACAM	HEPACAM	-1.55457435272231
HES4	HES4	-0.684559732369385
HES6	HES6	0.664661467759123
HEXA	HEXA	0.779112113626974
HEY1	HEY1	-0.672154594605684
HEY2	HEY2	-0.927465596825524
HEYL	HEYL	-0.919965427975008
FAM203B	HGH1	0.850481676833388
HGS	HGS	0.60551259055624
HHATL	HHATL	0.629956775668476
HIF1A	HIF1A	0.622873148980694
HIF1AN	HIF1AN	0.643697847979054
HIGD1A	HIGD1A	-0.539033020407329
HIGD1B	HIGD1B	-0.552320200416751
HINT1	HINT1	0.57930501729219
HIPK2	HIPK2	-0.715837011159078
HIST1H1C	HIST1H1C	-1.07614466049843
HIST2H2AA3	HIST2H2AA3/HIST2H2AA4	-0.915625305605215
HIST2H2AC	HIST2H2AC	-0.752524279759444
HK1	HK1	0.568908636707586
HLA-DOA	HLA-DOA	0.51098655740735
HLA-DRB1	HLA-DRB1	-0.540512880385463
HLA-DRB4	HLA-DRB4	-3.16094946435423
HLA-DRB6	HLA-DRB6	0.743163635415506
HLA-F	HLA-F	0.518600602264105
HLA-G	HLA-G	0.905675636676492
HLA-H	HLA-H	0.986273492190604
HLCS	HLCS	1.61921742842829
HMBS	HMBS	1.49426720375135
HMGA1	HMGA1	1.38201316182262
HMGCL	HMGCL	0.583523942853159
HMGCS1	HMGCS1	1.24423413480865
HMOX1	HMOX1	1.05763510754514
HNMT	HNMT	-0.940103193683677
HNRNPH1	HNRNPH1	-0.537180196717403
HNRNPK	HNRNPK	0.711305794695072
HOGA1	HOGA1	-0.551306607049578
HOMER2	HOMER2	1.7843641848691
HOMER3	HOMER3	0.684584812176723
HOXA9	HOXA9	1.38056112439482
HP	HP	-0.514109337079517
HPS6	HPS6	0.57848894100366
HRAS	HRAS	0.899248490303593
HRSP12	HRSP12	-0.565073300888747
HS2ST1	HS2ST1	0.843090509468715
HS3ST3A1	HS3ST3A1	0.737323366170264
HSD11B1L	HSD11B1L	0.784809956332935
HSD11B2	HSD11B2	0.710275568574773
HSD17B11	HSD17B11	-0.798394543211492
HSD17B14	HSD17B14	1.46840045470342
HSD17B8	HSD17B8	0.791135548433394
HSDL1	HSDL1	0.50844796891321
HSPA13	HSPA13	0.606147121038923
HSPA1B	HSPA1A/HSPA1B	-0.759276932014099
HSPA2	HSPA2	1.8870290125379099
HSPA4	HSPA4	0.918288055179501
HSPA5	HSPA5	2.48390008190106
HSPA8	HSPA8	0.592013725707284
HSPA9	HSPA9	1.18078415726444
HSPB7	HSPB7	-0.627676525418781
HSPE1	HSPE1	0.500838698579166
HYAL1	HYAL1	-0.719092062622591
HYOU1	HYOU1	0.992888272364965
IARS	IARS	1.31989487140714
ICA1	ICA1	-0.677789151822049
ICK	ICK	-0.552554514873421
ICT1	ICT1	0.640246320232038
ID1	ID1	0.60968049272182
ID3	ID3	-0.508145436962054
ID4	ID4	-1.10373214991746
IDH1	IDH1	0.609333921620296
IDO1	IDO1	-0.626586162744089
IDUA	IDUA	0.795880519103957
IER2	IER2	-0.78015411942559
IER3	IER3	-1.10979045128969
IER5L	IER5L	0.785166334028626
IFFO2	IFFO2	1.00157095401543
IFI27	IFI27	-0.546348868535486
IFI27L1	IFI27L1	0.841787258147252
IFI27L2	IFI27L2	1.78521625515669
IFIT2	IFIT2	-0.622449823370972
IFNAR2	IFNAR2	-0.523515281834627
IFRD1	IFRD1	0.902370223510421
IFT122	IFT122	0.583436531074154
IGF2BP2	IGF2BP2	-0.563072353369596
IGF2R	IGF2R	0.676475083820772
IGFBP3	IGFBP3	0.976515687804499
IGFBP4	IGFBP4	1.94677102814834
IGFBP6	IGFBP6	-0.537588361291225
IGSF1	IGSF1	-0.906793010983586
IGSF10	IGSF10	0.925529980808039
IGSF8	IGSF8	0.903089864871369
IKBKG	IKBKG	0.601672564675122
IL10RA	IL10RA	0.543926307770422
IL11RA	IL11RA	1.30674526502567
IL17D	IL17D	0.664414138253193
IL17RC	IL17RC	0.94248879177219
IL18RAP	IL18RAP	-0.513776712218106
IL20RB	IL20RB	3.0518046767489
IL34	IL34	1.52196975348416
IL6	IL6	-3.15187378692622
ILVBL	ILVBL	0.633452570110539
IMMT	IMMT	0.526820029970195
IMP4	IMP4	0.918574278360138
IMPA2	IMPA2	0.528608368613775
IMPDH2	IMPDH2	0.910247063251448
ING1	ING1	-0.70490241730323
INHBB	INHBB	-0.688409437522387
INHBE	INHBE	0.863837622033787
INO80B	INO80B	0.531796275410174
INPPL1	INPPL1	0.660602374020075
INTS1	INTS1	0.598800066510215
INTS4L1	INTS4P1	0.501284972786925
IP6K1	IP6K1	0.543291601690822
IP6K3	IP6K3	2.62460647259114
IPO13	IPO13	1.05634992360827
IPO4	IPO4	0.96244939844269
IPO9	IPO9	0.574693784773243
IQCC	IQCC	0.67200326570804
IRAK1	IRAK1	0.770734640149855
IRF2BP1	IRF2BP1	0.682352458195407
IRF2BP2	IRF2BP2	0.701412394500744
IRF2BPL	IRF2BPL	-0.645337709913177
IRF3	IRF3	0.621224201280186
IRS2	IRS2	-0.638888395528915
IRX3	IRX3	0.841197003877775
IRX5	IRX5	0.961988646537875
IRX6	IRX6	-1.0432524140295
ISCU	ISCU	0.524594796265805
ISG20	ISG20	-0.933303518389312
ISLR	ISLR	1.30560343292374
ISM1	ISM1	0.527245823002565
ISOC2	ISOC2	0.650867082875585
ITGA1	ITGA1	-0.846809922150659
ITGA10	ITGA10	0.79558918382432
ITGA11	ITGA11	1.35487501450009
ITGA3	ITGA3	1.75318979358044
ITGA7	ITGA7	0.793153572009951
ITGAM	ITGAM	0.52094988334378
ITGB1BP1	ITGB1BP1	-1.08718596190408
ITM2A	ITM2A	-0.78178511619925
ITM2C	ITM2C	-0.841598195607185
ITPA	ITPA	0.61298867919157
ITPK1	ITPK1	-0.564975454451861
ITPR2	ITPR2	-0.593179910973785
ITSN1	ITSN1	-1.08771811103115
IVD	IVD	0.690948287603274
IGJ	JCHAIN	-0.626325349732761
JMJD8	JMJD8	0.580504243066029
JOSD2	JOSD2	0.518945043791579
JUN	JUN	-1.84551488804252
JUNB	JUNB	-1.73992927263623
KANK1	KANK1	-0.834932858431255
KANK3	KANK3	-0.545492487862052
KANSL3	KANSL3	0.625230877634018
KAT2A	KAT2A	0.705428242049165
KAT2B	KAT2B	-0.508076048174815
KATNB1	KATNB1	0.80721531620435
KAZALD1	KAZALD1	0.637003957181463
KAZN	KAZN	1.19107138840547
KBTBD11	KBTBD11	0.920835494192773
KCNAB1	KCNAB1	-0.648899927909149
KCND2	KCND2	0.523650838135014
KCNG1	KCNG1	4.29623276956478
KCNIP4	KCNIP4	0.685256780605698
KCNJ2	KCNJ2	-0.691101566402396
KCNJ8	KCNJ8	-0.821216238195153
KCNK12	KCNK12	0.554421429591554
KCNK15	KCNK15	0.74181374291104
KCNK3	KCNK3	0.532371742621299
KCNMA1	KCNMA1	0.846763291463395
KCNS3	KCNS3	-0.57012191362531
KCTD1	KCTD1	0.887217686712603
KCTD10	KCTD10	-0.702452487767162
KCTD13	KCTD13	0.698861772704059
KDELR3	KDELR3	-0.507842226418192
KDR	KDR	-0.526987945844167
KEAP1	KEAP1	0.602758161058356
KHDC1	KHDC1	0.610192900820074
KIAA0040	KIAA0040	-0.880689106541902
KIAA0368	KIAA0368	0.664789916523785
KIAA0391	KIAA0391	0.966303466857688
KIAA0513	KIAA0513	0.643712142644417
KIAA0922	KIAA0922	-0.7847429412635
KIAA0930	KIAA0930	0.536945768402062
KIAA1147	KIAA1147	-0.611018243165995
KIAA1191	KIAA1191	0.601727972996068
KIAA1211L	KIAA1211L	-0.510022676202943
KIAA1217	KIAA1217	-0.758216051402644
KIAA1549L	KIAA1549L	0.655266543385725
KIAA1551	KIAA1551	-0.730337264196742
KIF1A	KIF1A	2.70864146698179
KIF21A	KIF21A	0.928150155347055
KIF25	KIF25	-2.30595808823143
KIF2A	KIF2A	0.584772485575586
KIF3B	KIF3B	0.628797705872629
KIF5B	KIF5B	0.677157336567218
KIF7	KIF7	2.37492079910315
KIFC2	KIFC2	0.565625264766407
KIT	KIT	1.01850610542958
PLK1S1	KIZ	0.744272031666522
KLF2	KLF2	-1.13339872767513
KLF4	KLF4	-2.28707720776554
KLF6	KLF6	-0.820743665729346
KLF9	KLF9	-0.669349988017355
KLHDC3	KLHDC3	0.537953590684148
KLHDC4	KLHDC4	1.26753008883857
KLHDC7B	KLHDC7B	0.921435716781304
KLHDC8B	KLHDC8B	1.14192984629687
KLHDC9	KLHDC9	0.754821111325338
KLHL35	KLHL35	0.930201493537652
KLHL5	KLHL5	1.3036000471476
SETD8	KMT5A	0.505166653490567
KPNA2	KPNA2	0.641177831578034
KRT8	KRT8	1.20770875898838
KTN1	KTN1	-0.502303745190359
LACTB	LACTB	1.0344495215162
LAGE3	LAGE3	1.46261862477332
LAMA2	LAMA2	-1.08318641552886
LAMC3	LAMC3	2.68574687846394
LAMP2	LAMP2	0.700814202537215
LAMP3	LAMP3	1.43605441826192
LAMTOR2	LAMTOR2	0.599278730130573
LARGE	LARGE	0.895978947049055
LARP4	LARP4	0.587097488585398
LARP6	LARP6	1.47535995512485
LARS	LARS	0.693153542649935
LBP	LBP	-1.12212398318428
LCLAT1	LCLAT1	0.563130436184995
LCMT1	LCMT1	0.745198703878193
LDHD	LDHD	0.58457069481551
LDLR	LDLR	0.610681828500866
LDLRAP1	LDLRAP1	0.529833142737238
LDOC1	LDOC1	-0.50128929946591
LEP	LEP	-4.22377981011314
LEPR	LEPR	-0.833879078399546
LGMN	LGMN	0.794952059631103
LHCGR	LHCGR	-1.2551568681446
LHFPL2	LHFPL2	0.775447815059349
LHPP	LHPP	0.536340594980839
LIG1	LIG1	0.654959420677261
LIG3	LIG3	0.872872959293991
LILRA6	LILRA6	0.881949924512852
LILRB5	LILRB5	0.869765591259574
LIMA1	LIMA1	0.630882893357657
LIMCH1	LIMCH1	-1.88769572813759
LIMS1	LIMS1	0.679306815260714
LINC00152	LINC00152	0.99204372247007
LINC00312	LINC00312	-0.967792873463642
LINC00339	LINC00339	-0.811432442943293
LINC00467	LINC00467	1.14041461668235
LINC00623	LINC00623	-0.541761665708026
LINC00667	LINC00667	-0.642930848112893
LIPE	LIPE	-0.589401208569317
LIPG	LIPG	0.572203035074211
LITAF	LITAF	0.615661059334247
LLGL1	LLGL1	0.76256236493353
LMAN2L	LMAN2L	0.605006071587195
LMCD1	LMCD1	-0.923234277716742
LMNA	LMNA	0.560583527856272
LMO3	LMO3	-1.82509101713765
LMO4	LMO4	0.633194480034065
LOC100133920	LOC100133920	-0.556937050050179
LOC100287896	LOC100287896	0.769359777310397
LOC100505715	LOC100505715	0.949690610683346
SIK1	LOC102724428/SIK1	-1.66005848812554
PRODH	LOC102724788/PRODH	1.83153227031631
MRPL23	LOC102724828/MRPL23	0.671290748460694
LOC148413	LOC148413	0.646031630127336
LOC286254	LOC286254	0.585446144213739
LOC401052	LOC401052	-1.26116733022661
LOC407835	LOC407835	0.843240982419545
LOC644936	LOC644936	-0.941216074921107
LONP1	LONP1	2.0686049495324
LONP2	LONP2	0.581716111503697
LOX	LOX	-0.611896250462918
LPAR1	LPAR1	0.771827795461873
LPAR5	LPAR5	0.70209555363086
LPGAT1	LPGAT1	-0.660044540068069
LPIN1	LPIN1	0.618087621205193
LPIN2	LPIN2	0.557085230622744
LPP	LPP	-0.512776209163933
LRBA	LRBA	0.571335811545691
LRFN4	LRFN4	1.02213460133164
LRP1B	LRP1B	-0.767447171507185
LRP8	LRP8	1.14490663533488
LRPPRC	LRPPRC	0.610737770311404
LRRC16A	LRRC16A	0.719057229564244
LRRC2	LRRC2	1.536858841142
LRRC20	LRRC20	0.850644739095309
LRRC25	LRRC25	0.561313171874255
LRRC28	LRRC28	0.648369894409531
LRRC29	LRRC29	0.549194210453443
LRRC41	LRRC41	0.537451883341078
LRRC47	LRRC47	0.502754673063091
FAM211B	LRRC75B	0.880107094393475
LRRC8B	LRRC8B	0.680152694626239
LRRK2	LRRK2	-0.512765695839102
LRRN3	LRRN3	-0.985166101806519
LRRN4CL	LRRN4CL	1.61768428181137
LRSAM1	LRSAM1	0.583918286068177
LSM10	LSM10	0.738189168698318
LSM4	LSM4	0.6489207702006
LSM7	LSM7	0.55060872188997
LSP1	LSP1	0.563742524098608
LSS	LSS	0.827865458079237
LTBP2	LTBP2	-0.536351877046687
LTBR	LTBR	0.795653771766583
LUM	LUM	0.804367974736206
LXN	LXN	-0.50660366541862
LY6E	LY6E	0.788025264159999
LY96	LY96	0.676923867872877
LYN	LYN	-0.63678593226236
LYSMD2	LYSMD2	-0.720929208074195
LYVE1	LYVE1	0.607835643818848
LYZ	LYZ	-0.963959523202076
LZTR1	LZTR1	0.52355469251708
MACROD1	MACROD1	1.12472193101971
MAD2L2	MAD2L2	0.976728479750786
MAF	MAF	0.69142629041581
MAFG	MAFG	0.512627837583128
MAL2	MAL2	0.816284637284527
MALSU1	MALSU1	0.525247268621457
MAMDC2	MAMDC2	-0.609647095450765
MAMSTR	MAMSTR	0.508968661109133
MAN1B1	MAN1B1	1.21465160055777
MAN1C1	MAN1C1	0.655102113077957
MAN2B1	MAN2B1	0.683343692856715
MAN2C1	MAN2C1	0.64816905327499
MANSC1	MANSC1	-0.550151914994051
MAOA	MAOA	-0.510648938686303
MAP1A	MAP1A	1.27556669455783
MAP1B	MAP1B	1.20683044512523
MAP2K2	MAP2K2	0.555270177787846
MAP2K3	MAP2K3	0.567100248238044
MAP2K5	MAP2K5	0.535848655463058
MAP3K12	MAP3K12	0.831384665137259
MAP3K8	MAP3K8	-1.56601530787205
MAP4K4	MAP4K4	0.56812932175084
MAP6	MAP6	0.868237000077972
MAP7	MAP7	-0.697830953662434
MAPK7	MAPK7	0.799967186538237
MAPK8IP2	MAPK8IP2	2.57456507851166
MAPK8IP3	MAPK8IP3	0.501463822119425
MAPKAP1	MAPKAP1	1.37307233638287
MAPKAPK2	MAPKAPK2	0.578961542500564
MAPRE3	MAPRE3	1.81103669061253
MARCH2	MARCH2	-0.600722684091113
MARCH8	MARCH8	0.562960659964089
MARCO	MARCO	1.67815465085276
MARS	MARS	1.22169480381022
MASP1	MASP1	0.826830655865977
MAST2	MAST2	0.532403356472934
MAST4	MAST4	0.70211390558341
MATK	MATK	0.830601734599881
MATN2	MATN2	1.14774437943431
MBD2	MBD2	-0.685072211118282
MBD3	MBD3	1.04471776668939
MBNL3	MBNL3	-0.584209814011662
MBOAT7	MBOAT7	0.531684970216604
MBP	MBP	1.59530056311583
MCAM	MCAM	0.501978194737326
MCEE	MCEE	-0.753383805201639
MCL1	MCL1	-1.10311860112496
MCM2	MCM2	0.702188067405996
MCOLN1	MCOLN1	0.827188822882189
MCOLN3	MCOLN3	-1.77375937813882
MCRS1	MCRS1	0.667113305801231
MCTP1	MCTP1	-0.825112176911537
MCTS1	MCTS1	0.592187655430601
CCDC90A	MCUR1	0.587516563364445
MDK	MDK	0.628106574064853
ME1	ME1	1.35809907487092
ME2	ME2	0.91049858935365
MEA1	MEA1	0.558536078215
MECOM	MECOM	-1.1787468361387199
MECR	MECR	1.05574855346763
MED16	MED16	1.18714579968476
MED20	MED20	0.871928026482975
MED22	MED22	1.05423920592183
MED24	MED24	0.717681720436137
MED30	MED30	-0.557849942011898
MED9	MED9	0.950747695871565
MEG3	MEG3	1.03689759834111
MEGF8	MEGF8	0.59015106353564
MEGF9	MEGF9	1.28220235903497
MEOX2	MEOX2	-0.658376800089054
MESP1	MESP1	0.575107852771908
METAP2	METAP2	0.849059503796872
METTL1	METTL1	1.19710156361415
METTL22	METTL22	0.833822708006954
METTL5	METTL5	-0.638745916326034
MEX3B	MEX3B	-0.730609955533521
MFAP2	MFAP2	1.2776486730053
MFAP4	MFAP4	1.24779564862383
MFAP5	MFAP5	-0.585118591350402
MFSD12	MFSD12	0.993712390329802
HIATL1	MFSD14B	0.755961132296685
MFSD3	MFSD3	1.44020052980292
MFSD5	MFSD5	0.766341572332852
MGAT4B	MGAT4B	0.849467996314343
MGMT	MGMT	0.799964077219488
MGP	MGP	0.723225739193542
MGRN1	MGRN1	0.699963950634857
MIA	MIA	0.511962743948317
MIB2	MIB2	0.531281057819687
MICALL1	MICALL1	1.31363001431164
MICALL2	MICALL2	0.892993933053328
MICU1	MICU1	0.853179287838912
MID1IP1	MID1IP1	1.17594372709867
MIF	MIF	0.91767302468792
MIF4GD	MIF4GD	0.64078765651796
MIOS	MIOS	0.53672782805017
MIPEP	MIPEP	0.522826871196919
MIR21	mir-21	-1.0218175097864
MIR22HG	MIR22HG	-1.72629212816362
LINC00478	MIR99AHG	0.56740173496236
MKL2	MKL2	-0.527390990067332
MKNK2	MKNK2	1.16257972624235
MKX	MKX	1.1860168625388
MLF2	MLF2	0.761179057778962
MLKL	MLKL	-0.545132548063969
MLST8	MLST8	1.13399775036948
MMD	MMD	-1.14138287541434
MME	MME	-0.773640354868547
MMP2	MMP2	0.531578464204057
MMP23B	MMP23B	0.621456485592969
MMP25	MMP25	-1.1045022422049
MMP28	MMP28	0.733884471288788
MMP9	MMP9	0.592115271198548
MN1	MN1	0.886377192790655
MNDA	MNDA	-0.56473625177549
MNS1	MNS1	0.709715173566174
MOCOS	MOCOS	3.4916360852854
MORN4	MORN4	0.815659838090002
MPPE1	MPPE1	-0.541274874169619
MPV17	MPV17	0.753688072040304
MPZL2	MPZL2	-0.748548213454694
MRPL12	MRPL12	0.704000221651608
MRPL14	MRPL14	0.694444138017725
MRPL15	MRPL15	0.682784467613775
MRPL17	MRPL17	0.744747109675216
MRPL2	MRPL2	0.849538206337926
MRPL22	MRPL22	0.512557939513389
MRPL24	MRPL24	0.560496028170087
MRPL27	MRPL27	0.593252453090935
MRPL37	MRPL37	0.893925840239529
MRPL38	MRPL38	0.922399752770354
MRPL4	MRPL4	0.539017667761731
MRPL40	MRPL40	0.576555906231244
MRPL43	MRPL43	0.625858149753123
MRPL48	MRPL48	1.00340727697117
MRPL51	MRPL51	0.535807144252767
MRPL55	MRPL55	0.920469343010421
MRPS12	MRPS12	0.735953938286831
MRPS15	MRPS15	0.853329983105959
MRPS18A	MRPS18A	0.59617497203921
MRPS18B	MRPS18B	0.586379897516788
MRPS2	MRPS2	0.703825177229345
MRPS21	MRPS21	0.643335719769946
MRPS24	MRPS24	0.615424663890929
MRPS25	MRPS25	0.580863702530078
MRTO4	MRTO4	0.586790676859148
MS4A14	MS4A14	0.773421899965698
MS4A2	MS4A2	1.06308711024877
MS4A4A	MS4A4A	0.725541259238665
MS4A7	MS4A7	0.706981132018475
MSANTD3	MSANTD3	0.898659194375686
MSC	MSC	2.6867266188454
MSMO1	MSMO1	1.43295810896914
MSRA	MSRA	0.972090696889297
MSRB1	MSRB1	-0.9301500415467
MSRB2	MSRB2	0.517885886461466
MSRB3	MSRB3	-1.74445797477969
MST1	MST1	0.718558835303524
MT1A	MT1A	-1.18909542729336
MT1E	MT1E	-2.19349463340348
MT1F	MT1F	-0.70023510604898
MT1G	MT1G	-0.550346544390726
MT1IP	MT1IP	-1.47408601602558
MT1L	MT1L	-0.608549708145745
MT1M	MT1M	-2.0955195415929
MT1P3	MT1P3	-1.36872423157165
MT1X	MT1X	-0.977911021284362
MT2A	MT2A	-1.04744675111151
MTCH2	MTCH2	0.596701430271902
MTFP1	MTFP1	0.585768259651839
MTG1	MTG1	0.518500807531671
MTHFD1L	MTHFD1L	1.69099669985835
MTHFD2	MTHFD2	1.28431540794196
MTHFSD	MTHFSD	0.512168039660762
MTMR14	MTMR14	0.557619787384384
MTMR2	MTMR2	0.652610151376916
MTOR	MTOR	0.516261638879915
MTSS1	MTSS1	0.811353583813646
MTSS1L	MTSS1L	0.928400752028116
C7orf41	MTURN	-0.850100842354672
MTUS1	MTUS1	-0.638199004861649
MTX1	MTX1	0.646523288013488
MUSTN1	MUSTN1	-0.815851265488588
MVB12A	MVB12A	0.685426467390698
MVD	MVD	0.827747029136277
MXRA5	MXRA5	0.541269632593499
MXRA7	MXRA7	0.597343781785177
MYADM	MYADM	-1.30560947790689
MYC	MYC	-1.62539168054444
MYCN	MYCN	0.512458134861574
C19orf10	MYDGF	0.729843393659623
MYEOV	MYEOV	-0.70818013795226
MYH1	MYH1	-1.14909066606903
MYH11	MYH11	-1.8026730812991
MYL3	MYL3	0.538130261927194
MYL5	MYL5	0.684765566076744
MYL6B	MYL6B	0.768754608158984
MYLK	MYLK	-0.548737541986394
MYO10	MYO10	-0.557835105725568
MYO16	MYO16	-0.600243971572697
MYO1D	MYO1D	1.14818798134697
MYO5A	MYO5A	0.886651470772092
MYOC	MYOC	-1.50288100390836
MYOF	MYOF	0.540763620800072
MYOM1	MYOM1	-0.529206961223325
MYOM2	MYOM2	0.50323885428708
MYPOP	MYPOP	0.78348458477289
MYRFL	MYRFL	0.83968493785875
MYRIP	MYRIP	-0.652600407086326
MYZAP	MYZAP	-0.997076715212708
MZT2A	MZT2A	0.521604361549161
N4BP1	N4BP1	0.62303463741647
N6AMT1	N6AMT1	1.67498682692751
NAA10	NAA10	1.41183471256322
NAA35	NAA35	0.554484939184166
NAA60	NAA60	0.93264221563091
NAALAD2	NAALAD2	-0.592230694749998
NAB1	NAB1	-0.501001139127528
NABP1	NABP1	0.791616834648986
NABP2	NABP2	0.617693535233338
NACC2	NACC2	0.563776963762757
NADKD1	NADK2	0.511814596868091
NAGK	NAGK	0.90255554714602
NAGLU	NAGLU	1.10595355280632
NANOS1	NANOS1	0.986451009299988
NAP1L4	NAP1L4	1.9635885885677
NAPB	NAPB	0.983387524489435
NARFL	NARFL	0.648782763836361
NARS	NARS	0.708322198004655
NAT10	NAT10	0.698081325856916
NAT14	NAT14	0.700716209917914
NAT8L	NAT8L	-0.819153939152334
NAV1	NAV1	-0.509819196300388
NBAS	NBAS	0.53521313745037
NBEA	NBEA	-0.542381058344555
NCAPH2	NCAPH2	0.697751187908562
NCBP2	NCBP2	0.601900202596899
NCDN	NCDN	1.08373106295352
NCF2	NCF2	0.657444879683002
NCKAP1L	NCKAP1L	0.522930634853985
NCKIPSD	NCKIPSD	0.997003875063081
NCL	NCL	0.563834287489646
NCLN	NCLN	0.964519273998441
NCOA7	NCOA7	0.511865580134675
NCSTN	NCSTN	0.664788472353673
NDNF	NDNF	-0.960802730848784
NDRG1	NDRG1	-0.52517794925349
NDST2	NDST2	0.630570678446826
NDUFA10	NDUFA10	0.784451293825504
NDUFA13	NDUFA13	0.670185284477957
NDUFA7	NDUFA7	0.784305641064186
NDUFA9	NDUFA9	0.674738426690635
NDUFAB1	NDUFAB1	0.55430347710513
NDUFAF2	NDUFAF2	0.714377986483234
NDUFAF3	NDUFAF3	0.669744145944538
NDUFAF4	NDUFAF4	0.704591707173829
NDUFB10	NDUFB10	0.518611418610894
NDUFB9	NDUFB9	0.501874791767291
NDUFS3	NDUFS3	0.63016002666239
NDUFS7	NDUFS7	0.694001677618715
NDUFS8	NDUFS8	0.710047047213541
NDUFV1	NDUFV1	0.806437900607017
NECAB2	NECAB2	0.959707156320944
NECAP2	NECAP2	0.523515182545976
NEDD4L	NEDD4L	-0.611150551964944
NEDD9	NEDD9	-0.709513200804918
NEK11	NEK11	0.708077986377264
NEK7	NEK7	-0.840683171255709
NELFB	NELFB	0.820068546812299
NELFE	NELFE	0.645766984054622
NENF	NENF	0.673161946149513
NEO1	NEO1	1.05926067225804
NET1	NET1	-1.64431628867212
NEU1	NEU1	0.808510934154052
NEURL4	NEURL4	0.58434732671138
NFE2L1	NFE2L1	1.08791516463386
NFIX	NFIX	0.508922299663722
NFKBIA	NFKBIA	-1.25923411761982
NFKBIZ	NFKBIZ	-2.75898727356869
NFX1	NFX1	0.512589167048321
NGF	NGF	0.839144549032575
NGRN	NGRN	0.640541756101278
NHP2	NHP2	0.640322815315568
NID2	NID2	0.877966230955057
NINJ1	NINJ1	1.4602251671658
NINL	NINL	0.504217682480397
NIPA2	NIPA2	0.511005789093146
NIPSNAP1	NIPSNAP1	0.700681911224471
NIPSNAP3A	NIPSNAP3A	0.559366220038094
NKAP	NKAP	0.915295898489733
NKD2	NKD2	2.55901313491086
NKIRAS2	NKIRAS2	0.797596303356411
NLE1	NLE1	0.667071635520257
NLGN1	NLGN1	-0.671089919762624
NLGN4X	NLGN4X	-1.10560250806081
NLRP3	NLRP3	-0.953809145539592
NLRX1	NLRX1	0.817170200212121
NME1	NME1	1.29310139873074
NME1-NME2	NME1-NME2	0.59175895222444
NMNAT2	NMNAT2	-1.38381264530031
NMT1	NMT1	0.505925053493495
NMUR2	NMUR2	0.527887177206712
NNAT	NNAT	-0.751793837748177
NNMT	NNMT	-0.991368091530789
NOC3L	NOC3L	0.62656818830217
NOL12	NOL12	0.93970883338648
NOL3	NOL3	0.509317354836896
NOL6	NOL6	0.590958809125617
NOL7	NOL7	0.509230214393302
NOMO2	NOMO1 (includes others)	0.975904336449325
NOP16	NOP16	0.878536973408591
NOP2	NOP2	0.762321752861436
NOSIP	NOSIP	0.532822326159657
NOTCH1	NOTCH1	-0.50508200077626
NOX4	NOX4	-1.66069912519161
NPAS2	NPAS2	2.09674445986342
NPIP	NPIPA8 (includes others)	0.614167683313903
NPL	NPL	0.712320527098086
NPM3	NPM3	1.13636903825947
NPR3	NPR3	-2.30868868078374
NPRL2	NPRL2	0.568804496976222
NPRL3	NPRL3	0.981553771033095
NPTX2	NPTX2	-0.571619913796391
NPTXR	NPTXR	0.756090267119378
NPY5R	NPY5R	-1.56262798938989
NQO1	NQO1	0.519058239478433
NQO2	NQO2	0.527531240178302
NR1D1	NR1D1	0.603970931242043
NR2C2AP	NR2C2AP	0.591594277377101
NR2F6	NR2F6	0.810782241964636
NR4A2	NR4A2	-2.97526210598779
NR4A3	NR4A3	-0.963042597519837
NR5A2	NR5A2	-0.688613571162414
NRBP1	NRBP1	0.576915706390765
NRDE2	NRDE2	0.741257954381996
NREP	NREP	1.2523668725968
NRP1	NRP1	-0.563187384639871
NRSN2	NRSN2	0.839231562971753
NRXN2	NRXN2	2.02320490430002
NSF	NSF	0.718276222537351
NSFL1C	NSFL1C	0.588186234934816
NSMAF	NSMAF	1.37531125910546
NSMF	NSMF	1.29392298373369
NSUN4	NSUN4	0.536571262006238
NSUN5	NSUN5	0.547402155384841
NT5C	NT5C	0.561691985192559
NTM	NTM	-0.623228263007671
NTMT1	NTMT1	0.894934708358679
NTPCR	NTPCR	0.815150572058617
NTRK3	NTRK3	-0.508873219341585
NUCB2	NUCB2	1.07889046138001
NUDT14	NUDT14	0.803524101393916
NUDT16L1	NUDT16L1	0.758513850768437
NUDT2	NUDT2	0.619385919925835
NUDT22	NUDT22	0.698017519604656
NUP155	NUP155	0.662292257265611
NUP210L	NUP210L	0.534230987863934
NUP43	NUP43	0.576656017252797
NUP93	NUP93	0.632089428584319
NUPR1	NUPR1	1.2266774655623
NUSAP1	NUSAP1	0.80449101360121
NXNL1	NXNL1	-1.09484265901352
OAF	OAF	1.53002756144877
OCIAD2	OCIAD2	-0.671090901307002
ODC1	ODC1	0.620273246839973
OGFOD1	OGFOD1	0.637216903541501
OGFOD3	OGFOD3	0.631166027946763
OGN	OGN	0.79449326205175
OLFM2	OLFM2	1.70673955312463
OLFML2A	OLFML2A	-0.834974704915682
OLFML2B	OLFML2B	0.804163627516494
OLFML3	OLFML3	0.648372002665762
OPLAH	OPLAH	1.07194555466667
OR2A9P	OR2A9P	0.594849054828894
ORAOV1	ORAOV1	0.548154959651572
ORM1	ORM1	0.573272787805383
ORM2	ORM2	0.817249461367889
ORMDL3	ORMDL3	-1.1962731824521
OSBPL10	OSBPL10	-0.522020796067982
OSBPL11	OSBPL11	1.17964773956621
OSBPL7	OSBPL7	0.766283921512568
OSCP1	OSCP1	0.984078149565253
OSGIN1	OSGIN1	1.43179377862547
OSGIN2	OSGIN2	0.717790724237232
OSR1	OSR1	-0.663365669542648
OTUB1	OTUB1	0.722300395213011
OTUB2	OTUB2	2.02298668763557
P2RX4	P2RX4	0.799134539370064
P2RX6	P2RX6	0.928312794079515
P2RX7	P2RX7	0.904188025643955
LEPRE1	P3H1	0.806408905632262
LEPREL2	P3H3	0.571346363641161
LEPREL4	P3H4	0.53223763166443
P4HA2	P4HA2	1.30789793865086
P4HTM	P4HTM	0.607727752934662
PA2G4	PA2G4	0.553391495480692
PACS1	PACS1	0.755614918613931
PACSIN3	PACSIN3	1.18665226906343
PADI4	PADI4	-1.33068697945259
PAG1	PAG1	0.972456654926627
PAICS	PAICS	0.762422279944904
PAK4	PAK4	0.526510041878542
PALM2	PALM2	0.748463403964482
PALMD	PALMD	-1.16231116851829
PAM16	PAM16	1.18221053932034
PAMR1	PAMR1	-0.816356215461284
PANK1	PANK1	1.54381074733913
PAPLN	PAPLN	0.769190178591802
PAQR7	PAQR7	0.746075939041147
PARM1	PARM1	-1.27197044093909
PARN	PARN	0.500993607825
PARP10	PARP10	0.959640605476357
PARP2	PARP2	0.575360320599582
PARP3	PARP3	0.723591532192283
PARP6	PARP6	0.617133733451017
PARVA	PARVA	-0.627480032251658
PARVB	PARVB	0.664934007380985
PATL1	PATL1	0.811725288164973
PAWR	PAWR	-0.547122508419972
PBX3	PBX3	-0.654876617086943
PC	PC	0.683741427383175
PCBD1	PCBD1	0.737215200340569
PCBP2	PCBP2	-0.608478847204619
PCCB	PCCB	1.12852083908703
PCDH17	PCDH17	0.54693780834135
PCDH7	PCDH7	0.722747106753133
PCDH9	PCDH9	-0.800736163818765
PCDHA1	PCDHA1	0.799584518498226
PCGF1	PCGF1	0.784624055607346
PCK2	PCK2	1.20268467707931
PCLO	PCLO	-0.537310296688836
PCMT1	PCMT1	0.536090051762223
PCMTD2	PCMTD2	-0.521076120562388
PCOLCE	PCOLCE	0.806430607772518
PCOLCE2	PCOLCE2	-1.33595935872948
PCSK5	PCSK5	-0.558636128588938
PCSK7	PCSK7	0.591063417843132
PCYT2	PCYT2	1.28857215328888
PDCD4	PDCD4	-0.552753816552024
PDCD6	PDCD6	0.516996995933146
PDCL3P4	PDCL3P4	0.769680105447468
PDDC1	PDDC1	0.865906408820003
PDE1B	PDE1B	0.572522121848074
PDE3B	PDE3B	-1.01158811447065
PDE8B	PDE8B	-1.99585812752994
PDGFD	PDGFD	-0.515229005746748
PDIA5	PDIA5	0.518353552816869
PDK4	PDK4	-1.00457387214084
PDLIM7	PDLIM7	0.661278711968775
PDXP	PDXP	1.14766671519688
PDZD2	PDZD2	-1.42580711553631
PDZRN3	PDZRN3	-0.795344070052071
PEA15	PEA15	0.779243234015693
PEBP1	PEBP1	0.726163646164358
PECR	PECR	0.521981013653801
PEF1	PEF1	0.669870039466057
PEG10	PEG10	3.3338571925545
PELI1	PELI1	-0.588538571500366
PEPD	PEPD	0.570611125909739
PERP	PERP	-0.934065796224664
PEX16	PEX16	0.942196623163238
PEX6	PEX6	1.24227416227363
PEX7	PEX7	0.602147422663489
PFKFB1	PFKFB1	-1.59772570810112
PFKFB3	PFKFB3	-2.09465374102918
PFKL	PFKL	0.899618473731275
PFN1	PFN1	0.589321806500642
PGA3	PGA5 (includes others)	-1.16361511652932
PGAP2	PGAP2	0.749832294423017
PGAP3	PGAP3	1.00652544550381
PGBD5	PGBD5	1.35520295176295
PGD	PGD	1.35673812249675
PGLS	PGLS	0.946748361517004
PGP	PGP	0.519218117777128
PHACTR3	PHACTR3	2.58220758404002
PHF19	PHF19	0.564704197041893
PHF23	PHF23	0.810883779560176
PHKG1	PHKG1	-0.500614449120801
PHLDA1	PHLDA1	-0.607221443886447
PHLDA2	PHLDA2	0.689402645673582
PHLDA3	PHLDA3	0.616803128252455
PHLDB2	PHLDB2	-1.00357623712858
PHLPP1	PHLPP1	-0.56711819523367
PHOSPHO2	PHOSPHO2	-1.06437148115318
PHPT1	PHPT1	0.970278442048101
PI16	PI16	-0.781059458542748
PI4KA	PI4KA	0.573747431301202
PI4KB	PI4KB	0.842953936113526
PIDD	PIDD1	0.733363110225157
PIGB	PIGB	-0.538407640047333
PIGO	PIGO	0.517045513070319
PIGQ	PIGQ	1.07555934741722
PIGT	PIGT	0.672269697839339
PIGU	PIGU	0.827115862873438
PIK3C2B	PIK3C2B	-0.570117700537336
PIK3R2	PIK3R2	1.11633872451446
PIN1	PIN1	0.500337460603354
PIP5K1C	PIP5K1C	1.05459639879945
PIR	PIR	0.694825056089324
PKD1	PKD1	0.755313951407196
PKIA	PKIA	0.84785919152994
PKM	PKM	1.61023692062618
PKN1	PKN1	1.2382969388712
PKP1	PKP1	-0.805111587224699
PKP2	PKP2	0.849440721536387
PLA2G15	PLA2G15	0.765467924423745
PLA2G2A	PLA2G2A	1.16890180414152
PLA2G4A	PLA2G4A	-0.513296262352315
PLA2G5	PLA2G5	0.55859518530724
PLAA	PLAA	1.14730156444002
PLAG1	PLAG1	1.21210945147061
PLAT	PLAT	-0.641140557021219
PLAUR	PLAUR	-0.524576831712736
PLBD2	PLBD2	1.54949477606408
PLCE1	PLCE1	-0.910281188484087
PLCXD3	PLCXD3	-0.560640668424565
PLD3	PLD3	0.87989202013134
PLEC	PLEC	0.519833946218484
PLEKHA2	PLEKHA2	0.599675054390635
PLEKHF1	PLEKHF1	0.820712384189634
PLEKHG4	PLEKHG4	0.850562693751798
PLEKHG6	PLEKHG6	-0.624213101428185
PLEKHH1	PLEKHH1	0.738754872456929
PLEKHH3	PLEKHH3	0.666991042672041
PLEKHM2	PLEKHM2	1.09100310208307
PLEKHO2	PLEKHO2	1.34714279188145
PLGRKT	PLGRKT	0.58901610030474
PLIN1	PLIN1	-1.85014963076253
PLIN2	PLIN2	2.17430192696151
PLLP	PLLP	-0.618176903019651
PLOD1	PLOD1	0.652263807385793
PLOD3	PLOD3	1.03157028006751
PLP2	PLP2	-0.517642844120614
PLS3	PLS3	-0.663963032448003
PLSCR4	PLSCR4	-0.7370428838379
PLTP	PLTP	1.58998868100734
PLXNA1	PLXNA1	0.981069701831097
PLXNA3	PLXNA3	0.924445450567288
PLXNB2	PLXNB2	1.07433349025285
PMEPA1	PMEPA1	-1.58209319463422
PMP22	PMP22	-0.501388601631218
PNCK	PNCK	0.555380509691437
PNKD	PNKD	1.22197101650765
PNMA1	PNMA1	0.537148022420395
PNMA2	PNMA2	0.912139780222084
PNMA6A	PNMA6A	0.880197918118277
PNMAL1	PNMAL1	1.46758610553413
PNPLA6	PNPLA6	1.15044873391973
PNPO	PNPO	0.854300485058023
PNRC2	PNRC2	-0.617781384740569
POC1A	POC1A	0.545498420711887
PODN	PODN	0.54129274383368
PODXL2	PODXL2	0.77495801778233
POFUT2	POFUT2	0.534721139750347
POLA2	POLA2	0.579073288467178
POLD1	POLD1	0.770658378046855
POLD2	POLD2	1.16905785721849
POLN	POLN	-0.765917005644645
POLR1C	POLR1C	0.842752210790709
POLR1E	POLR1E	0.815449106910931
POLR2G	POLR2G	0.550411185709735
POLR2H	POLR2H	0.64689861426131
POLR2I	POLR2I	0.518719650977148
POLR2J4	POLR2J4	-0.645348100127042
POLR3B	POLR3B	0.609445186398508
POLR3C	POLR3C	0.625430120711564
POLR3E	POLR3E	0.528744143835352
POLR3F	POLR3F	0.525636667142704
POLRMT	POLRMT	0.65355548020216
POMC	POMC	0.873985162660183
POMGNT1	POMGNT1	1.24826399310451
GTDC2	POMGNT2	0.662351481312796
POMZP3	POMZP3	0.549606945671255
POR	POR	0.887922574066929
PPAN	PPAN	0.736927385752862
PPDPF	PPDPF	1.15006260256504
PPFIBP2	PPFIBP2	1.23025044009619
PPIH	PPIH	0.607871646104564
PPIL1	PPIL1	0.652161405075465
PPIL6	PPIL6	0.933626402180026
PPIP5K1	PPIP5K1	0.502269381451398
PPOX	PPOX	0.568109077528999
PPP1CB	PPP1CB	-0.532138536088376
PPP1R11	PPP1R11	0.617508695414655
PPP1R14A	PPP1R14A	-1.91080660445196
PPP1R14B	PPP1R14B	0.818571730488331
PPP1R15A	PPP1R15A	-0.50671953298343
PPP1R16A	PPP1R16A	0.669300880957511
PPP1R16B	PPP1R16B	-0.63036667878065
PPP1R1A	PPP1R1A	-0.894156893703971
PPP1R1B	PPP1R1B	-1.01954439549224
PPP1R3C	PPP1R3C	0.808909654506363
PPP1R3F	PPP1R3F	1.45558413994533
PPP2R1A	PPP2R1A	0.789173884383306
PPP2R3B	PPP2R3B	0.563682208722289
PPP2R4	PPP2R4	1.03018308058712
PPP4C	PPP4C	0.535768366306999
SMEK2	PPP4R3B	-0.507952033515327
PPRC1	PPRC1	0.610210215131028
PQLC2	PQLC2	0.602652734183719
PRCD	PRCD	0.732564345619599
PRDM11	PRDM11	1.40566308607327
PRDX5	PRDX5	0.796675197633402
PREB	PREB	0.99218641589279
SLMO1	PRELID3A	0.853358711096809
PRELP	PRELP	-0.805725000934079
PRG4	PRG4	-1.14643904686285
PRKCD	PRKCD	-0.676350690349513
PRKCE	PRKCE	0.572478729040112
PRKCSH	PRKCSH	0.523786516322693
PRMT1	PRMT1	0.796953423765625
PRND	PRND	1.81684047172275
PRNP	PRNP	0.910238864261391
PROCR	PROCR	-0.841145642649393
PRPF19	PRPF19	0.649560205087484
PRPF31	PRPF31	0.51702185544282
PRPH	PRPH	-0.824751102779101
PRPSAP1	PRPSAP1	1.02644838243767
PRRT3	PRRT3	1.0894351400537
PRSS23	PRSS23	1.10933702942246
PRUNE2	PRUNE2	0.886796464395826
PSAT1	PSAT1	3.74356928823719
PSMA3	PSMA3	0.651212830094077
PSMA4	PSMA4	0.63544647545853
PSMB10	PSMB10	0.504141327123932
PSMB2	PSMB2	0.648140324960422
PSMB5	PSMB5	0.614469589111956
PSMB6	PSMB6	0.729929292790547
PSMB7	PSMB7	0.898286176534365
PSMD14	PSMD14	0.826076582309386
PSMD7	PSMD7	0.500650453094715
PSME2	PSME2	0.582516177984828
PSME3	PSME3	0.63591919378405
PSME4	PSME4	1.00251853467511
PSMG1	PSMG1	0.764548424320618
PSMG3	PSMG3	0.608378673837931
PSORS1C3	PSORS1C3	0.549190419182377
PTCD1	PTCD1	0.900138105643325
PTDSS2	PTDSS2	0.740029827894775
PTER	PTER	1.10346450990135
PTGDS	PTGDS	1.51854757021916
PTGER4	PTGER4	-1.15787091618664
PTGES2	PTGES2	0.984105080727803
PTGES3L-AARSD1	PTGES3L-AARSD1	0.822451348118932
PTGFR	PTGFR	0.674235820654634
PTGIS	PTGIS	-0.651847873983047
PTGS2	PTGS2	-2.63047219351715
PTK7	PTK7	1.05390036218077
PTMS	PTMS	0.672174354730933
PTOV1	PTOV1	0.519060447319211
PTPMT1	PTPMT1	0.627798451425403
PTPN23	PTPN23	0.503673416265222
PTPN3	PTPN3	0.612923216387919
PTPRA	PTPRA	0.560834782267338
PTPRB	PTPRB	-0.732906358066997
PTPRE	PTPRE	-0.553609161311463
PTPRF	PTPRF	0.565727398800091
PTPRK	PTPRK	0.650276533886288
PTPRT	PTPRT	0.574602708029151
PTRH1	PTRH1	0.82149063828843
PTS	PTS	0.753123193151683
PTTG1	PTTG1	0.731717426537349
PTX3	PTX3	1.62954071035545
PUF60	PUF60	0.667777432315603
PUS1	PUS1	0.739039653105002
PUSL1	PUSL1	0.803671073554276
PVR	PVR	0.503038343650015
PWWP2B	PWWP2B	0.935637100580219
PYCR1	PYCR1	0.509229538257142
PYCR2	PYCR2	0.677255008295791
PYGB	PYGB	1.22153564735562
PYGO2	PYGO2	0.567132174104688
QPCT	QPCT	0.653374250885679
QPRT	QPRT	1.92345542475223
QSOX1	QSOX1	1.190232606092
R3HDM4	R3HDM4	0.622730710127077
RAB11FIP3	RAB11FIP3	0.586644867476561
RAB11FIP5	RAB11FIP5	0.50476819237294
RAB26	RAB26	0.643675368061118
RAB32	RAB32	1.49157336888939
RAB34	RAB34	0.598215597333958
RAB38	RAB38	0.838731129238994
RAB3IL1	RAB3IL1	1.15039629252702
RAB3IP	RAB3IP	0.919796284739781
RAB40C	RAB40C	0.695508889154915
RAB43	RAB43	0.994752619693114
RAB4B	RAB4B	0.519275466567372
RAB5A	RAB5A	-0.504875914748771
RABEP1	RABEP1	0.876381907098479
RABL6	RABL6	0.7707955207727
RAD21	RAD21	-0.534334645626018
RAD23A	RAD23A	0.82119709682097
RAD51D	RAD51D	0.63332756914246
RAE1	RAE1	0.73284670992054
RALA	RALA	1.01060711066745
RAMP2	RAMP2	0.696439854888269
RAMP3	RAMP3	0.699545302901854
RAN	RAN	0.573599608629802
RANBP3	RANBP3	0.67777530326261
RANGAP1	RANGAP1	0.8146096790175
RAP1GAP	RAP1GAP	1.92046330820098
RAP1GDS1	RAP1GDS1	1.35712873637732
RAPGEF5	RAPGEF5	-0.723013819199789
RAPH1	RAPH1	0.500331397103928
RARA	RARA	0.604443634486111
RARRES1	RARRES1	-0.660730520811307
RARRES2	RARRES2	-1.54301700639618
RARRES3	RARRES3	1.06938885094668
RASD1	RASD1	-0.82345468446998
RASGRP2	RASGRP2	-0.582459576138892
RASL10B	RASL10B	0.648858631582423
RASSF5	RASSF5	0.660487525415289
RAVER2	RAVER2	0.51105682402246
RBBP8	RBBP8	0.579057886060965
RBBP9	RBBP9	0.552083125774017
RBCK1	RBCK1	1.0334573645486
RBKS	RBKS	0.500763065792915
RBM38	RBM38	0.601294488570969
RBM42	RBM42	0.609370465124665
RBM6	RBM6	0.527346988781835
RBP4	RBP4	-0.755742314610225
RBP5	RBP5	1.6582545865036
RBPMS	RBPMS	-0.574844302887441
RCAN1	RCAN1	0.507378171625573
RCAN2	RCAN2	-0.514753060664213
RCCD1	RCCD1	0.582200760460775
RCE1	RCE1	0.676963667576595
RCL1	RCL1	-0.777457139392778
RCN1	RCN1	0.592040984279187
RCN3	RCN3	0.853257520651744
RCOR2	RCOR2	1.08571530851659
RDH5	RDH5	-1.37087395305375
REEP2	REEP2	-0.753063288593336
REEP6	REEP6	-0.638739789600788
RELN	RELN	0.824976569379306
RENBP	RENBP	1.46393896459958
RER1	RER1	1.17134357203034
RERG	RERG	-0.593797384718642
RERGL	RERGL	-0.969946200870418
RET	RET	1.99811155485365
REXO2	REXO2	0.691941505607981
REXO4	REXO4	0.577849691849264
RFNG	RFNG	0.801591043148235
RFXANK	RFXANK	0.50175396255396
RGCC	RGCC	-1.06913386395544
RGL1	RGL1	0.548204412385655
RGN	RGN	-0.625300332844218
RGS1	RGS1	-1.94412458592165
RGS12	RGS12	0.796201956390488
RGS16	RGS16	-1.17666647242684
RGS17	RGS17	-0.730207900804229
RGS20	RGS20	1.00048655524889
RGS5	RGS5	-0.861741540316217
RHBDD1	RHBDD1	0.785762961825819
RHBDD2	RHBDD2	1.46686019856636
RHBDD3	RHBDD3	0.835253332175287
RHOB	RHOB	-1.02856250430356
RHOD	RHOD	1.15875202555765
RHOU	RHOU	0.542813403779353
RHOXF1	RHOXF1	-0.881273976144002
RHPN2	RHPN2	0.629075445155792
RILPL1	RILPL1	1.33900428445071
RIMS3	RIMS3	2.84130276205881
RIMS4	RIMS4	0.639980337891434
C12orf52	RITA1	0.779385705494015
RMND5B	RMND5B	0.726323597903357
RN7SK	RN7SK	-2.76563354686668
RNA18S5	RNA18S5	-0.735358161047533
RNA28S5	RNA28S5	-0.811001874111752
RNASE1	RNASE1	0.628898725297529
RNASE4	RNASE4	-1.37535939770997
RNASEH2A	RNASEH2A	0.743138320787271
RNASEH2C	RNASEH2C	0.627790510031473
RNASEK	RNASEK	0.71167351080793
RND2	RND2	0.939580396606441
RNF10	RNF10	0.708535730768914
RNF121	RNF121	0.60917942088811
RNF125	RNF125	-0.908822531843587
RNF126	RNF126	0.617379830971702
RNF135	RNF135	0.761529093010682
RNF144A	RNF144A	-1.06116793477644
RNF144B	RNF144B	-0.619402855369114
RNF157	RNF157	0.980534051674525
RNF165	RNF165	0.74508969551564
RNF181	RNF181	0.897367783661502
RNF185	RNF185	1.44132689736806
RNF24	RNF24	0.686850557407354
RNF26	RNF26	0.751984036094235
RNF38	RNF38	-0.836741148779612
RNH1	RNH1	1.04310710074126
RNLS	RNLS	0.910497210467823
RNMTL1	RNMTL1	0.594047355515567
RNPEP	RNPEP	0.518595918302051
RNPEPL1	RNPEPL1	0.722048674832787
RNU1-3	RNU1-3	-0.698894860275598
RNU4-1	RNU4-1	-0.626680393248193
RNU4-2	RNU4-2	-0.756921283391854
RNU1-9	RNVU1-7	-0.63333472114314
RNY1	RNY1	-0.91218614582168
RNY4	RNY4	-0.941088791620542
ROR1	ROR1	0.797243061814787
RP9	RP9	0.678872134096453
RP9P	RP9P	0.598180268485256
RPA1	RPA1	0.611211724102651
RPAP1	RPAP1	0.674427508016386
RPAP3	RPAP3	0.520750082908512
RPE	RPE	0.907964508926004
RPH3AL	RPH3AL	0.503367909848506
RPL13P5	RPL13P5	0.647476672004532
RPL14	RPL14	1.1259472149607
RPL34	RPL34	0.690296747684698
RPL39L	RPL39L	0.855440817700691
RPL6	RPL6	0.680490614710031
RPL7L1	RPL7L1	0.741314142103264
RPL8	RPL8	0.520452693023985
RPL9	RPL9	0.536416185261761
RPLP0	RPLP0	0.679314517201605
RPLP1	RPLP1	1.06626920426254
RPN2	RPN2	0.68284478604077
RPP21	RPP21	0.503505915005513
RPP25	RPP25	0.614509541295851
RPP40	RPP40	1.41398754413584
RPPH1	RPPH1	-0.931845802137319
RPS2	RPS2	0.572498832916772
RPS21	RPS21	0.58446897507241
RPS24	RPS24	0.805924989870948
RPS26P47	RPS26P47	0.617316513863305
RPS27L	RPS27L	0.870774765759062
RPS6KA4	RPS6KA4	0.538120207534501
RPS6KB2	RPS6KB2	0.6604666971596
RPUSD1	RPUSD1	0.515513890692528
RPUSD2	RPUSD2	0.861405094073397
RPUSD3	RPUSD3	0.956143761231866
RRAGC	RRAGC	1.03123882120829
RRAGD	RRAGD	0.688856148249811
RRAS2	RRAS2	0.57103092493687
RRBP1	RRBP1	0.729152112784609
RRM2B	RRM2B	0.815595305136859
RRP1	RRP1	0.650012745734748
RRP12	RRP12	0.817984652595255
RRP7A	RRP7A	0.527539331402834
RSAD1	RSAD1	0.907501199176277
RSG1	RSG1	0.608969851940847
RSPO3	RSPO3	0.581883895259105
RSU1	RSU1	-0.795160266370317
RTCA	RTCA	0.577272588474257
RTKN	RTKN	1.14280549240101
RTN1	RTN1	-1.09175432547348
RTN3	RTN3	0.606222243845758
RTN4	RTN4	-1.25973750205239
RTN4R	RTN4R	0.522341292507945
RUFY1	RUFY1	0.563048889984198
RUFY3	RUFY3	1.33373296343128
RUNDC3B	RUNDC3B	-0.530360428791008
RUNX1	RUNX1	0.807821710414959
RUVBL1	RUVBL1	0.517369589302801
S100A1	S100A1	-1.75078591630735
S100A16	S100A16	1.0077532957192
S100A8	S100A8	-2.69930463818157
S100A9	S100A9	-1.51753228167485
S100P	S100P	-0.809339865163656
S1PR1	S1PR1	-0.962644944085436
S1PR3	S1PR3	-0.506410156832817
SAA1	SAA1	-6.14634895910415
SAA2	SAA2	-2.88057036854193
SAA4	SAA4	-1.61409154801897
SAC3D1	SAC3D1	0.539581938796438
SAMD4A	SAMD4A	0.505626458300391
SAMD5	SAMD5	0.858514001421044
SARS	SARS	1.42493812077025
SARS2	SARS2	0.616393145333797
SATB2	SATB2	-0.713748939675306
SAYSD1	SAYSD1	0.58069420854717
SBF1	SBF1	1.26700299657535
SCAMP3	SCAMP3	1.07883983615239
SCAP	SCAP	0.582332024181467
SCARA3	SCARA3	2.23730069547342
SCARA5	SCARA5	-0.502208296928241
SCIN	SCIN	-0.670949356268455
SCNN1D	SCNN1D	0.588620491845288
SCO1	SCO1	0.673045454049711
SCRIB	SCRIB	0.708983585722159
SCRN1	SCRN1	1.52805618234925
SCUBE2	SCUBE2	-1.05128222132748
SDAD1	SDAD1	0.690638532408866
SDC4	SDC4	0.621949472544965
SDCBP	SDCBP	0.874383600001962
SDCCAG3	SDCCAG3	0.635989951678715
SDF2L1	SDF2L1	0.658522964357888
SDHAF1	SDHAF1	0.693456654558662
C6orf57	SDHAF4	0.824545825449272
SDHAP2	SDHAP2	0.804725462778378
SDPR	SDPR	-0.803942187371397
SDSL	SDSL	1.29426385814903
SEC13	SEC13	0.719901987599263
SEC61A1	SEC61A1	1.03429275586278
SELE	SELE	-1.79423476133911
SELM	SELM	0.500109595656923
SEMA3B	SEMA3B	-0.50700029518409
SEMA3C	SEMA3C	0.743214106162252
SEMA3G	SEMA3G	-1.41444266821772
SEMA6A	SEMA6A	-0.641235066487996
SEPHS2	SEPHS2	0.61457065574905
SERAC1	SERAC1	0.583675605009899
SERINC1	SERINC1	-0.660702096073308
SERINC2	SERINC2	1.83725790207976
SERP2	SERP2	1.36535665187186
SERPINA3	SERPINA3	2.17594637154938
SERPINE2	SERPINE2	2.49454036719647
SERPINH1	SERPINH1	1.06074811426819
SERPINI1	SERPINI1	1.12789382043029
SERTAD1	SERTAD1	-0.622277280018757
SERTAD4	SERTAD4	-0.742912745359001
SERTAD4-AS1	SERTAD4-AS1	-0.827463547294647
SESN2	SESN2	1.34498234894837
SF3A2	SF3A2	1.11141184581311
SF3B3	SF3B3	0.544039093344173
SF3B5	SF3B5	0.565520150086124
SFMBT1	SFMBT1	0.645925124527528
SFRP1	SFRP1	-1.84953075751713
SFRP2	SFRP2	-0.910430022069515
SFRP4	SFRP4	-2.07402069544736
SFTA1P	SFTA1P	-1.03677614427309
SFTPD	SFTPD	0.731798691485422
SFXN4	SFXN4	1.10108117455523
SFXN5	SFXN5	0.693503081264642
SGCB	SGCB	-0.679012744062198
SGCD	SGCD	0.582039762564234
SGCG	SGCG	1.01352038941438
SGK1	SGK1	-2.0766742332314
SGK223	SGK223	-0.650239268323002
SGPL1	SGPL1	0.632137734907815
SGSH	SGSH	1.03089422028779
SGTA	SGTA	0.557849454570479
SH3BP4	SH3BP4	0.55113654365342
SH3D19	SH3D19	-1.12377814705655
SH3GL1	SH3GL1	0.780891430444226
SH3GLB1	SH3GLB1	0.934521738020862
SH3GLB2	SH3GLB2	0.508594662381819
SH3PXD2A	SH3PXD2A	0.523668105660175
SH3PXD2B	SH3PXD2B	0.784333955208783
SH3RF3	SH3RF3	0.941909334079269
SHARPIN	SHARPIN	0.524510770392568
SHC1	SHC1	0.877791220302855
SHMT2	SHMT2	2.17095115851253
SHROOM4	SHROOM4	-0.579382390006221
SIAH2	SIAH2	0.740684105045801
SIGMAR1	SIGMAR1	0.720324975511878
SIL1	SIL1	0.58974131883317
SIN3B	SIN3B	0.725964084325302
SKIV2L	SKIV2L	0.628885919975074
SLAMF8	SLAMF8	0.742252195819351
SLC11A1	SLC11A1	-0.605729155156931
SLC12A2	SLC12A2	0.735967833114515
SLC12A8	SLC12A8	1.11657520989593
SLC15A3	SLC15A3	0.603940584451966
SLC15A4	SLC15A4	0.719165438806657
SLC16A2	SLC16A2	-0.747120895978151
SLC16A5	SLC16A5	1.31158573235552
SLC18B1	SLC18B1	0.740687583904046
SLC19A1	SLC19A1	0.781236677603779
SLC19A3	SLC19A3	-1.51068958006887
SLC1A3	SLC1A3	-1.15307567454156
SLC1A4	SLC1A4	1.06024813151383
SLC1A5	SLC1A5	1.29292216933736
SLC20A1	SLC20A1	0.743083005488028
SLC22A12	SLC22A12	2.20608111407019
SLC22A15	SLC22A15	1.34844565318827
SLC22A17	SLC22A17	0.543345378045206
SLC22A18	SLC22A18	0.90966648439174
SLC22A5	SLC22A5	1.23636354918921
SLC24A3	SLC24A3	0.590325476394456
SLC25A1	SLC25A1	1.25778072894914
SLC25A10	SLC25A10	0.832228946987319
SLC25A13	SLC25A13	0.644471245205508
SLC25A15	SLC25A15	0.919296757541897
SLC25A19	SLC25A19	0.73695871262047
SLC25A22	SLC25A22	1.53457766265395
SLC25A39	SLC25A39	1.05095698629733
SLC25A43	SLC25A43	0.538586902769203
SLC25A44	SLC25A44	0.549573964313356
SLC25A6	SLC25A6	0.714423540136008
SLC27A1	SLC27A1	0.720581222292545
SLC29A4	SLC29A4	0.952366738278821
SLC2A10	SLC2A10	0.710793286441049
SLC2A3	SLC2A3	-1.93316077223843
SLC2A5	SLC2A5	3.75609375602865
SLC2A6	SLC2A6	0.716048131772783
SLC2A8	SLC2A8	0.874194667443519
SLC31A2	SLC31A2	-0.934564687412812
SLC35A4	SLC35A4	0.620242184802836
SLC35B1	SLC35B1	0.678529683265595
SLC35B2	SLC35B2	0.521355303644557
SLC35B4	SLC35B4	0.661025358888587
SLC35C1	SLC35C1	0.830648025696925
SLC35F1	SLC35F1	-0.603167741849097
SLC35F6	SLC35F6	1.01206345052793
SLC35G2	SLC35G2	-0.545624930837039
SLC38A1	SLC38A1	1.62236846322261
SLC38A10	SLC38A10	1.40647648646682
SLC38A7	SLC38A7	0.580802393761712
SLC39A3	SLC39A3	1.40962680781726
SLC39A8	SLC39A8	-0.825783445427311
SLC3A2	SLC3A2	1.30181668755729
SLC41A2	SLC41A2	0.555397169328713
SLC47A1	SLC47A1	2.94375601116068
SLC48A1	SLC48A1	1.36548712106995
SLC4A11	SLC4A11	1.16613071531397
SLC4A2	SLC4A2	1.1080212172237
SLC4A3	SLC4A3	0.602743094162317
SLC4A7	SLC4A7	0.980206260541261
SLC52A2	SLC52A2	0.703802953143886
SLC6A10P	SLC6A10P	0.527455607236185
SLC6A16	SLC6A16	-0.524930658012582
SLC6A9	SLC6A9	0.574239769177842
SLC7A1	SLC7A1	2.34839777209074
SLC7A10	SLC7A10	-1.96391484547528
SLC7A2	SLC7A2	1.57892092766052
SLC7A5	SLC7A5	1.59774277746555
SLC7A6	SLC7A6	-0.547642960300094
SLC7A8	SLC7A8	0.575321191762073
SLC24A6	SLC8B1	0.5579989655607
SLC9A1	SLC9A1	1.456730985349
SLCO2A1	SLCO2A1	0.752075079854213
SLCO2B1	SLCO2B1	0.802282757542004
ANKRD32	SLF1	0.569278986381033
FAM178A	SLF2	0.507459610185701
SLIT2	SLIT2	0.714944983701964
SLIT3	SLIT3	0.87781988285583
SLK	SLK	-0.53798451994052
SLX4	SLX4	0.7269804035999
SMAD6	SMAD6	-1.072157144399
SMAD7	SMAD7	-1.1074010982465
SMAP1	SMAP1	0.664248698939801
SMARCB1	SMARCB1	0.844936792097831
SMG5	SMG5	0.623318315884265
SMG7	SMG7	-0.50510234320354
SMO	SMO	0.908445974319191
SMOC2	SMOC2	-0.823144509741428
SMOX	SMOX	0.825786708096785
SMPD1	SMPD1	1.15689559681173
SMPDL3A	SMPDL3A	-0.514924675816134
SMUG1	SMUG1	0.696787374270199
SNAP47	SNAP47	0.740603014631624
SNAPC2	SNAPC2	0.600651716808625
SNAPC4	SNAPC4	0.657234328910004
SNAR-A1	SNAR-A1	-0.558774108802651
SNHG11	SNHG11	0.549234602226319
SNHG7	SNHG7	0.834477102607651
SNHG8	SNHG8	-0.887374783315834
SNORA12	SNORA12	-1.53307762290024
SNORA31	SNORA31	-0.631002140649999
SNORA41	SNORA41	-0.734863419780511
SNORA59A	SNORA59A	0.733532352547391
SNORA61	SNORA61	0.508698580248196
SNORA67	SNORA67	-0.702147475338323
SNORD13	SNORD13	-1.12308755443826
SNORD14C	SNORD14C	-0.506962709724276
SNORD97	SNORD97	0.543432436648419
SNRK	SNRK	-0.892757973595587
SNRPB	SNRPB	0.642202394126004
SNTA1	SNTA1	1.23763295313909
SNTB1	SNTB1	0.741586793807241
NHP2L1	SNU13	0.64383095511318
SNUPN	SNUPN	0.597866837084099
SNX1	SNX1	-0.544653252782128
SNX10	SNX10	0.739301535001399
SNX16	SNX16	-0.606305035226092
SNX27	SNX27	0.594337716523622
SNX8	SNX8	0.708861322800152
SOBP	SOBP	0.898888306791472
SOCS2	SOCS2	-0.954733162125925
SOCS3	SOCS3	-2.51084793536182
SOGA1	SOGA1	0.590045215802052
SORBS1	SORBS1	-1.9649388587651
SORCS2	SORCS2	0.720877888421495
SORD	SORD	0.509698453829383
SORL1	SORL1	-0.644725230653793
SOS1	SOS1	-0.508359804778572
SOWAHC	SOWAHC	0.547627838013608
SOX17	SOX17	-1.70266598486551
SOX7	SOX7	-0.578177504916631
SOX9	SOX9	1.21396497273752
SP110	SP110	-0.571044537179707
SPAG8	SPAG8	0.644522328978215
SPARC	SPARC	-0.50947096446733
SPATA18	SPATA18	0.947232319920911
SPATC1L	SPATC1L	0.621304189381926
SPATS2L	SPATS2L	0.769919633631844
SPHK2	SPHK2	0.776475396849239
SPI1	SPI1	0.636747101185455
SPINT2	SPINT2	0.514628603457437
SPIRE1	SPIRE1	0.772138669715687
SPIRE2	SPIRE2	1.13541250252165
SPNS1	SPNS1	0.564635114458148
SPOCD1	SPOCD1	0.824527417845648
SPON1	SPON1	-1.57236082529376
SPP1	SPP1	2.05420187203472
SPPL2B	SPPL2B	0.511038003031019
SPRY1	SPRY1	-0.984090557621782
SPRY2	SPRY2	-0.627373017206469
SPSB2	SPSB2	0.702334748479805
SPTBN1	SPTBN1	-1.45608925070302
SPTLC2	SPTLC2	-0.519597130778419
C12orf39	SPX	-0.746680658382767
SQLE	SQLE	1.53724618279571
SQSTM1	SQSTM1	0.76148962334536
SRC	SRC	0.609209898969352
SRD5A1	SRD5A1	0.548463518159073
SRGAP1	SRGAP1	0.987531021575834
SRGAP3	SRGAP3	0.566442968834103
SRGN	SRGN	-1.2227558850337
SRM	SRM	1.12060615838242
SRPK3	SRPK3	0.55645681822389
SRPR	SRPRA	0.54931468582633
SRPRB	SRPRB	0.78859020978809
SRPX	SRPX	0.626031264020272
SRSF3	SRSF3	-0.672830866542536
SRXN1	SRXN1	1.81317950394583
SSPO	SSPO	0.555588147145021
SSU72	SSU72	0.590955652441232
ST3GAL3	ST3GAL3	0.529428526711328
ST3GAL4	ST3GAL4	0.617058379119082
ST3GAL6	ST3GAL6	-0.802477383672914
ST6GALNAC2	ST6GALNAC2	1.02630959150578
ST6GALNAC3	ST6GALNAC3	-1.49622019528477
ST6GALNAC4	ST6GALNAC4	0.647218636323284
STAB1	STAB1	0.938276863979043
STAG3L2	STAG3L2/STAG3L3	0.554805109426338
STAMBPL1	STAMBPL1	1.2039051221965
STARD13	STARD13	-0.644695724264777
STARD5	STARD5	0.623571417757454
STARD7	STARD7	1.12627527313526
STC1	STC1	-1.30757270297525
STC2	STC2	1.1232985413091
STIM1	STIM1	0.939706777220448
STIP1	STIP1	0.932508885761367
STK19	STK19	0.741096736067041
STK24	STK24	0.570860441964859
STK32A	STK32A	0.501297420370455
STK36	STK36	0.964848544675824
STK39	STK39	1.17786335017726
STK40	STK40	1.29101741747098
STOM	STOM	-0.712677783646218
STOML1	STOML1	0.770883175559024
STOML2	STOML2	0.717665304987449
STON1	STON1	-0.841561811423123
STRN4	STRN4	0.900876715767204
STUB1	STUB1	1.15136494957034
STX11	STX11	-1.2432953837643
STX1A	STX1A	0.620345645201204
STX6	STX6	0.590586410002676
STXBP1	STXBP1	0.800292713649678
STXBP6	STXBP6	-0.710325068471418
STYXL1	STYXL1	0.912597253563613
SUCLA2	SUCLA2	-0.712317961090888
SUGP2	SUGP2	0.911971211828561
SULF1	SULF1	-0.9164129358659
SULF2	SULF2	-0.584567835023336
SUN1	SUN1	-0.502099786025139
SUPV3L1	SUPV3L1	0.964208622611501
SURF1	SURF1	0.556752190155208
SUSD1	SUSD1	0.971396061706117
SUSD2	SUSD2	-0.667696859634194
SV2B	SV2B	-0.873167738517033
SVEP1	SVEP1	0.609508388338852
SWAP70	SWAP70	-0.512984714496286
SWI5	SWI5	0.633966358088159
SYBU	SYBU	0.734896618611736
SYN1	SYN1	0.741570768172245
SYN2	SYN2	-1.60944683757833
SYNM	SYNM	0.752221299584381
SYT11	SYT11	-0.566568847742641
SYTL2	SYTL2	-0.512636851438371
TACC2	TACC2	-0.531596915456908
TACO1	TACO1	0.739136207029865
TADA3	TADA3	0.59422729721595
TAF10	TAF10	1.13220248679298
TAF1C	TAF1C	0.670432687072295
TAF6	TAF6	0.502546889347516
TAF9B	TAF9B	-0.513962057153723
TAGLN	TAGLN	-0.962200526887239
TALDO1	TALDO1	0.68548826250828
TANC2	TANC2	1.08444266764674
TANGO2	TANGO2	1.52296403896908
TAPT1-AS1	TAPT1-AS1	0.5077736017866
TARS	TARS	0.813457314217773
TARS2	TARS2	0.627870077924991
TAX1BP3	TAX1BP3	0.636754214125381
TAZ	TAZ	0.598513540646796
TBC1D10B	TBC1D10B	0.739177591243044
TBC1D13	TBC1D13	0.668088921961632
TBC1D16	TBC1D16	0.566272058994634
WDR67	TBC1D31	1.35721055143782
TBC1D7	TBC1D7	1.49959556541528
TBC1D8	TBC1D8	0.548952334020965
TBCA	TBCA	0.653904392897552
TBCB	TBCB	0.543949095732209
TBCD	TBCD	0.702353485965223
TBL3	TBL3	0.564525673191321
TBRG4	TBRG4	0.98782174513115
TBX15	TBX15	0.542742921418075
TCEA1	TCEA1	1.01649415867649
TCEA2	TCEA2	0.532222048396097
TCEA3	TCEA3	1.09820641408327
TCEB2	TCEB2	0.610644227320681
TCTEX1D2	TCTEX1D2	0.616713386620297
TCTN1	TCTN1	0.588531738376075
TECR	TECR	0.830071086089137
TEF	TEF	0.588864994179092
TEK	TEK	-0.903231564863351
TEKT4P2	TEKT4P2	-0.671762668323453
TENM3	TENM3	-0.941128387169389
TENM4	TENM4	2.79033871957735
TESK1	TESK1	0.913641394152278
TET1	TET1	0.511942216538944
TEX2	TEX2	0.553565082816195
TEX264	TEX264	0.617295539985646
TF	TF	-1.09594436628942
TFF3	TFF3	-1.01303371255753
TFG	TFG	0.574299881642181
TFPI2	TFPI2	-0.694389026037104
TFRC	TFRC	-0.733912490630352
TGFBR2	TGFBR2	-0.562981318459782
TGFBR3	TGFBR3	-0.642910819967852
TGM2	TGM2	-1.55863107746642
THAP10	THAP10	0.792469680780976
THAP7	THAP7	0.632324551320647
THAP8	THAP8	0.615401057116744
THBD	THBD	-0.636294513334055
THBS1	THBS1	-2.30257363862231
THBS3	THBS3	0.646531677761179
THBS4	THBS4	-1.91773887541061
THEM6	THEM6	0.907077979466656
THNSL2	THNSL2	0.745373645802268
THOC3	THOC3	0.73231925894846
THOP1	THOP1	0.820019299347302
THRA	THRA	0.988587148862066
THRSP	THRSP	0.699029451711919
THSD7B	THSD7B	-0.657839764387373
THY1	THY1	1.05428479231513
THYN1	THYN1	0.667312400842348
TIGD2	TIGD2	0.578674512645976
TIGD5	TIGD5	1.42984769347932
TIMM10	TIMM10	0.971005980082314
TIMM17B	TIMM17B	0.68701128902831
TIMM23	TIMM23	0.65261283212836
TIMM44	TIMM44	0.730653303917711
TIMM8B	TIMM8B	0.79658262965532
TIMP1	TIMP1	0.956000457791402
TIMP4	TIMP4	-1.34885825753502
TINAGL1	TINAGL1	-0.593764105905445
TIPARP	TIPARP	-0.913582720929807
TIPRL	TIPRL	0.690062378376382
TJP1	TJP1	-0.834982460202134
TJP2	TJP2	-0.591230279425113
TK2	TK2	0.692509427683109
TLE1	TLE1	-0.797082028503543
TLN2	TLN2	0.994052177626632
TM4SF1	TM4SF1	-0.774999449396808
TM6SF1	TM6SF1	-0.645087851257658
TM7SF2	TM7SF2	-0.71820331898912
TMBIM1	TMBIM1	-0.528059785608122
TMED1	TMED1	0.547159172211422
TMED2	TMED2	-0.553593889643496
TMED3	TMED3	1.17423453036833
TMED5	TMED5	-0.514793367166315
TMED9	TMED9	0.615621870838883
TMEM100	TMEM100	-0.89657552089856
TMEM104	TMEM104	0.642860351748055
TMEM106C	TMEM106C	0.546632692087345
TMEM119	TMEM119	1.16065342401132
TMEM127	TMEM127	0.635249762141942
TMEM132B	TMEM132B	0.572740478214636
TMEM134	TMEM134	1.22944869127643
TMEM138	TMEM138	0.696325310473938
TMEM139	TMEM139	-0.666341786654031
TMEM141	TMEM141	1.07645036536278
TMEM147	TMEM147	1.04185241698964
TMEM150A	TMEM150A	0.589898131123012
TMEM156	TMEM156	0.702473695877474
TMEM158	TMEM158	0.979231470274751
TMEM165	TMEM165	-0.577513184107718
TMEM169	TMEM169	0.778256052903742
TMEM177	TMEM177	0.689177705498592
TMEM178A	TMEM178A	-0.725456782025277
TMEM179B	TMEM179B	0.516987720849194
TMEM19	TMEM19	-0.563063949362447
TMEM2	TMEM2	-0.642353107487126
TMEM201	TMEM201	1.05710825723043
TMEM203	TMEM203	0.582583431233981
TMEM205	TMEM205	0.745536237489047
TMEM208	TMEM208	0.652209568728758
TMEM219	TMEM219	0.705774755008603
TMEM222	TMEM222	0.592161820621614
TMEM223	TMEM223	0.528798594549222
TMEM234	TMEM234	0.738755136362677
TMEM259	TMEM259	0.515946838563028
TMEM37	TMEM37	-1.69700246248377
TMEM39B	TMEM39B	0.516589345444793
TMEM41B	TMEM41B	0.679003891033993
TMEM42	TMEM42	0.586634082711559
TMEM63B	TMEM63B	0.56573983609797
TMEM79	TMEM79	0.565298346860392
TMEM88	TMEM88	-0.547817165766181
TMEM8A	TMEM8A	1.15964257209307
TMEM8B	TMEM8B	0.733797582789172
KIAA0195	TMEM94	0.500888515153708
TMEM97	TMEM97	0.879985742993648
TMEM98	TMEM98	0.717461678923861
TMEM9B	TMEM9B	0.525724586657961
TMIE	TMIE	0.994425340731324
TMOD1	TMOD1	-0.7465888533516
TNFAIP3	TNFAIP3	-0.789154522249558
TNFAIP8	TNFAIP8	-0.543412449573113
TNFRSF10B	TNFRSF10B	0.918465725716835
TNFRSF12A	TNFRSF12A	0.750271010411588
TNFRSF14	TNFRSF14	0.666786214533027
TNFRSF19	TNFRSF19	-0.617273553665838
TNFRSF21	TNFRSF21	0.62527479438903
TNFRSF4	TNFRSF4	-0.533307712114125
TNFSF10	TNFSF10	-0.991844757534477
TNIP1	TNIP1	-0.783984613049455
TNK2	TNK2	0.503821868726706
TNMD	TNMD	-1.78228936362448
TNPO2	TNPO2	0.604113363369949
TNS1	TNS1	-1.3428683624051
TOB1	TOB1	-0.575768844133862
TOM1L2	TOM1L2	0.840204007880134
TOMM34	TOMM34	1.01703948333635
TOMM40	TOMM40	1.07136090938059
TOMM40L	TOMM40L	0.831421160197832
TOX2	TOX2	1.55899057406314
TP53BP1	TP53BP1	0.744468553215325
TP53TG3	TP53TG3B (includes others)	1.11701522093858
TPGS2	TPGS2	-1.25632249545546
TPI1P2	TPI1P2	0.56141278065764
TPM1	TPM1	0.763438894384645
TPO	TPO	-0.503907008196671
TPP1	TPP1	1.03801132322438
TPPP3	TPPP3	-0.692550768568603
TPR	TPR	-1.78610834620085
TPRG1	TPRG1	-0.531814210357516
TPRN	TPRN	0.522984227519351
TPSAB1	TPSAB1/TPSB2	1.9033701176452
TPST2	TPST2	0.551254684650844
TPTEP1	TPTEP1	0.57725635499954
TRAP1	TRAP1	0.837302913163107
TRAPPC1	TRAPPC1	0.858211191884045
TRAPPC2	TRAPPC2	-1.08629607570293
TRAPPC2L	TRAPPC2L	0.574940821341249
TRAPPC3	TRAPPC3	0.712957705601802
TRAPPC5	TRAPPC5	0.690087485965224
TRAPPC6A	TRAPPC6A	0.666793584036457
TRAPPC9	TRAPPC9	0.95630988008136
TRIAP1	TRIAP1	0.572840962592048
TRIB1	TRIB1	-0.895195452364718
TRIB3	TRIB3	5.13498000181961
TRIM28	TRIM28	0.877784926995399
TRIM29	TRIM29	0.597987269936385
TRIM35	TRIM35	0.561349360579007
TRIM39	TRIM39	0.519437886559807
TRIM47	TRIM47	0.945427290007484
TRIM5	TRIM5	-0.740126972683934
TRIM6	TRIM6	-0.766562928901841
TRIM69	TRIM69	0.548709137884892
TRIOBP	TRIOBP	1.2224182383786
TRIP6	TRIP6	0.840468708970247
TRIT1	TRIT1	0.559992503139881
TRMT1	TRMT1	0.539442049414675
TRMT10A	TRMT10A	0.528695813509875
TRMT112	TRMT112	0.529613320904756
TRMT12	TRMT12	0.898914824934317
TRMT61A	TRMT61A	0.504074723872226
TRO	TRO	0.704690971578995
TRPC4AP	TRPC4AP	0.524082113157602
TRPM8	TRPM8	0.534818359303711
TRPT1	TRPT1	0.617850448819652
TSC2	TSC2	0.670788051463455
TSC22D1	TSC22D1	1.00567804821791
TSC22D4	TSC22D4	0.510316610868156
TSEN15	TSEN15	0.568058233913734
TSEN54	TSEN54	0.556760664224349
TSHZ2	TSHZ2	0.782936991581318
TSPAN1	TSPAN1	-0.80781087290545
TSPAN10	TSPAN10	0.50696982830628
TSPAN13	TSPAN13	-1.61201115223635
TSPAN14	TSPAN14	0.541719722178084
TSPAN17	TSPAN17	0.627939227270977
TSPAN6	TSPAN6	-0.551194206665438
TSR3	TSR3	0.93624538229766
TSSC1	TSSC1	0.864730065875481
TSTA3	TSTA3	0.55844927707554
TSTD1	TSTD1	-0.929929104231527
TTC1	TTC1	0.597306668754264
TTC23	TTC23	1.4199891771189
TTC32	TTC32	-0.702456376101705
TTC4	TTC4	0.678468350607584
TTLL12	TTLL12	0.923459313169217
TTLL3	TTLL3	0.661917978468012
TTLL4	TTLL4	0.65907350576873
TTYH1	TTYH1	0.756865541241862
TTYH3	TTYH3	0.750183002109446
TUB	TUB	2.46692367496732
TUBA1C	TUBA1C	1.02495277281732
TUBB	TUBB	0.685166994078717
TUBB2A	TUBB2A	1.15425804985876
TUBB2B	TUBB2B	-0.57252567753333
TUBB7P	TUBB7P	0.653477199426481
TUBG1	TUBG1	0.692090409338131
TUBGCP2	TUBGCP2	0.510184766064306
TUFM	TUFM	0.608009333836332
TUFT1	TUFT1	1.31959106795513
TULP3	TULP3	0.694055440047856
TUSC5	TUSC5	-1.05979957144958
TXN	TXN	1.35288663729245
TXNDC12	TXNDC12	1.13730884906439
TXNL1	TXNL1	0.730821420839592
TXNRD1	TXNRD1	1.17724938141565
TXNRD2	TXNRD2	0.806064673432594
TYMP	TYMP	0.501274302416833
TYRO3	TYRO3	1.07710624410598
TYROBP	TYROBP	0.555394539579448
TYSND1	TYSND1	0.598230431980327
UAP1L1	UAP1L1	1.27238412213613
UBA1	UBA1	0.520940963213844
UBALD1	UBALD1	0.504088614938855
UBASH3B	UBASH3B	0.582531514242545
UBE2E2	UBE2E2	0.700859936129479
UBE2I	UBE2I	0.58680963320532
UBE2M	UBE2M	0.956053054590995
UBE2Q1	UBE2Q1	0.510364149137091
UBE2Z	UBE2Z	0.503527548657992
UBL4A	UBL4A	0.759543531367257
UBL7	UBL7	0.559883171734951
UBQLN4	UBQLN4	0.815955505642769
UBXN1	UBXN1	0.595848905980849
UBXN11	UBXN11	0.701024482504281
UBXN6	UBXN6	0.728415482967642
UCHL1	UCHL1	1.58514216269228
UCP2	UCP2	1.02279853652552
UHRF1BP1	UHRF1BP1	0.507219374935344
UNC13B	UNC13B	0.56352798060776
UNC5B	UNC5B	1.91880689907603
UNG	UNG	1.1247860353255
UPK3BL	UPK3BL	0.528792365320853
UPP1	UPP1	0.9664640744946
MNF1	UQCC2	1.87255295468636
C11orf83	UQCC3	0.679851364045944
UQCR10	UQCR10	0.506280481438639
UQCRC1	UQCRC1	0.716248896811819
UQCRH	UQCRH	0.574510264982832
URM1	URM1	0.61932200573485
UROS	UROS	1.28267805531315
USMG5	USMG5	0.991113418998244
USP36	USP36	-0.680298522654309
USP39	USP39	0.559448960078403
USP47	USP47	0.735140064808578
USP5	USP5	1.1811653708275
UTP11L	UTP11L	0.744012136956351
CIRH1A	UTP4	0.531838682864874
UVRAG	UVRAG	-1.108597377979
VAC14	VAC14	1.11971647917793
VAMP1	VAMP1	0.548559165902172
VAPA	VAPA	0.720445758502086
VARS	VARS	0.841465643430185
VARS2	VARS2	0.559245058575358
VAT1	VAT1	1.07658277618346
VAV3	VAV3	-0.682561017576536
VCAM1	VCAM1	1.67253600460188
VCAN	VCAN	0.715105925554324
VEGFC	VEGFC	-0.775956412028364
VHL	VHL	0.530865814792657
VIPAS39	VIPAS39	0.579365764877343
VIT	VIT	-0.753392564864253
VKORC1	VKORC1	0.657046784015905
VNN2	VNN2	-0.942569995904269
VPS18	VPS18	0.897917910406033
VPS25	VPS25	0.693126035683812
VPS26B	VPS26B	0.707009066456286
VPS28	VPS28	0.552669187744422
VPS37A	VPS37A	0.660074610002229
VPS37D	VPS37D	1.21975802556676
VPS4A	VPS4A	0.737349399810451
VPS4B	VPS4B	-0.748307819922701
VPS52	VPS52	0.578133638050763
VPS9D1	VPS9D1	0.807362172787461
VSIG4	VSIG4	0.53472989073839
VTI1B	VTI1B	0.515694380156349
VTRNA1-1	VTRNA1-1	-0.677617106882769
VWA5A	VWA5A	0.545731118545986
VWCE	VWCE	1.13207743833925
WARS	WARS	1.00437854894842
WARS2	WARS2	0.989767212908343
WAS	WAS	0.547085075985275
WASF3	WASF3	-0.515860069754904
WASH2P	WASH2P	0.699606868592247
WASH3P	WASH3P	0.600280115133183
WBP2	WBP2	0.584776121365427
WBP5	WBP5	-0.544670439621502
WBSCR22	WBSCR22	0.819484085899249
WDFY1	WDFY1	0.52170686787241
WDR12	WDR12	0.697725968098606
WDR13	WDR13	0.674043469186991
WDR18	WDR18	0.958018081152954
WDR25	WDR25	0.744371675592986
WDR34	WDR34	0.622067722183829
WDR4	WDR4	0.997572385349514
WDR41	WDR41	0.544198596149704
WDR45	WDR45	0.519920852945104
WDR46	WDR46	0.654949951452677
WDR47	WDR47	0.570412419943044
WDR5	WDR5	0.697654883251481
WDR55	WDR55	0.627754197017676
WDR81	WDR81	0.628961384310006
WDR83OS	WDR83OS	0.537826187140491
WDR86	WDR86	-1.78841835831408
WDSUB1	WDSUB1	0.822757678332472
WNT5B	WNT5B	1.57976190162189
WSB1	WSB1	0.610815509887152
WSB2	WSB2	1.22816712585265
XAF1	XAF1	-0.518640864030321
NA	XK	-4.42600133782392
XPNPEP1	XPNPEP1	0.758886026900515
XPNPEP2	XPNPEP2	0.885330453628777
XPO5	XPO5	0.571025498865961
XPO6	XPO6	0.633524137797103
XPOT	XPOT	1.03253013390639
XRN2	XRN2	-0.894944069212644
XXYLT1	XXYLT1	0.530796987087484
XYLT2	XYLT2	0.719232760664476
YARS	YARS	1.93107283046126
YBX2	YBX2	0.96219675204972
YIF1A	YIF1A	0.787783524813218
YIF1B	YIF1B	1.06362134124244
YIPF5	YIPF5	0.618795999901434
YME1L1	YME1L1	0.702624430294865
ZAK	ZAK	0.894069638152512
ZBTB42	ZBTB42	0.789833282512144
ZBTB47	ZBTB47	0.660392838044351
ZBTB7C	ZBTB7C	-0.543443778896716
ZBTB9	ZBTB9	0.549937757345498
ZC2HC1C	ZC2HC1C	0.620540636212346
ZC3HC1	ZC3HC1	0.672056403056482
ZCWPW1	ZCWPW1	0.74343264496167
ZDHHC1	ZDHHC1	0.830318342265213
ZDHHC24	ZDHHC24	0.865594579550974
ZDHHC4	ZDHHC4	0.617426394845584
ZDHHC7	ZDHHC7	0.542591223063496
ZER1	ZER1	0.530118599076412
ZFAND2A	ZFAND2A	0.537201434686031
ZFAND2B	ZFAND2B	0.796644711767668
ZFAND3	ZFAND3	0.878220583706627
ZFAS1	ZFAS1	0.948364948851673
ZFP36	ZFP36	-2.96113761536657
ZFP36L2	ZFP36L2	-0.553938573143482
ZFP42	ZFP42	-0.788625316140011
ZFPL1	ZFPL1	0.503475088760251
ZFPM1	ZFPM1	0.628394037849167
ZFPM2	ZFPM2	0.52408738772043
ZFYVE19	ZFYVE19	0.575582699868471
ZHX2	ZHX2	0.736572437515473
ZKSCAN2	ZKSCAN2	0.639059124915333
ZMAT3	ZMAT3	1.06875292204168
ZMYND12	ZMYND12	0.586807165203307
ZMYND15	ZMYND15	0.660283783820125
ZMYND19	ZMYND19	0.773030772028357
ZNF135	ZNF135	0.794166280872046
ZNF16	ZNF16	0.523474766687297
ZNF174	ZNF174	0.525668278349572
ZNF205	ZNF205	0.556932078389467
ZNF234	ZNF234	0.624174650538431
ZNF239	ZNF239	0.612349746994399
ZNF252P	ZNF252P	0.664834600644002
ZNF26	ZNF26	0.563962697217458
ZNF263	ZNF263	0.511837915292303
ZNF282	ZNF282	0.63414048914753
ZNF285	ZNF285	0.782727963366318
ZNF296	ZNF296	0.623572224017786
ZNF330	ZNF330	1.04589600069214
ZNF334	ZNF334	0.865299747617177
ZNF358	ZNF358	0.689846420491439
ZNF395	ZNF395	-0.622614583170837
ZNF404	ZNF404	0.538820729034268
ZNF408	ZNF408	0.580296803583133
ZNF419	ZNF419	0.821242323121655
ZNF428	ZNF428	0.923487122676588
ZNF493	ZNF493	0.656311759717139
ZNF521	ZNF521	0.61947513973134
ZNF524	ZNF524	0.570035087253622
ZNF544	ZNF544	0.626307135239852
ZNF579	ZNF579	1.1394554933601
ZNF580	ZNF580	0.544843006344546
ZNF581	ZNF581	0.770527213260824
ZNF585A	ZNF585A	0.602210409084792
ZNF593	ZNF593	0.746676728619663
ZNF598	ZNF598	0.98123906744909
ZNF605	ZNF605	0.501260561329681
ZNF606	ZNF606	0.75571227456736
ZNF608	ZNF608	-0.536062339947816
ZNF616	ZNF616	0.503983112027171
ZNF75D	ZNF75D	0.603346761999712
ZNF787	ZNF787	0.81586421620081
ZNF84	ZNF84	0.642270931917241
ZNF91	ZNF91	1.5043706525826
ZNHIT1	ZNHIT1	0.691271888259983
ZNHIT2	ZNHIT2	0.731263801998906
ZNRD1	ZNRD1	0.658383586668902
ZP3	ZP3	0.641170647220931
ZNF259	ZPR1	1.00116394335762
ZSCAN18	ZSCAN18	0.527324413591538
ZSWIM1	ZSWIM1	0.577104500798835
ZSWIM3	ZSWIM3	0.505729258388432

