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Ingenuity Pathway Analysis Results for P3

Analysis Details for My Projects->David Bulger->P3
Workspace	My Projects
Project	David Bulger
Analysis	P3
Date	Mon May 16 10:33:31 PDT 2016
Analysis ID	13377521

Analysis Settings
Cutoff before duplicate resolution	true
Resolve duplicate on	Expression foldchange
Color using	Expression foldchange
Cutoff for Expression foldchange	1.5	and consider Both up/down regulated
Cutoff for Expression pvalue	--
Cutoff for Expression qvalue	0.01
Reference set	Ingenuity Knowledge Base (Genes Only)
Relationship to include	Direct and Indirect
Includes Endogenous Chemicals	Yes
Optional Analyses	My Pathways My List
Filter Summary	
Consider only molecules and/or relationships where
(confidence = Experimentally Observed) AND
(mol. types = biologic drug OR chemical - endogenous mammalian OR chemical - endogenous non-mammalian OR chemical - kinase inhibitor OR chemical - other OR chemical - protease inhibitor OR chemical drug OR chemical reagent OR chemical toxicant OR complex OR cytokine OR disease OR enzyme OR function OR G-protein coupled receptor OR group OR growth factor OR ion channel OR kinase OR ligand-dependent nuclear receptor OR mature microRNA OR microRNA OR other OR peptidase OR phosphatase OR transcription regulator OR translation regulator OR transmembrane receptor OR transporter)

Canonical Pathways for My Projects->David Bulger->P3
Ingenuity Canonical Pathways	 -log(p-value)	zScore	Ratio	Molecules
4-1BB Signaling in T Lymphocytes	-0E00	NaN	3.23E-02	MAPK10,	
ATM Signaling	-0E00	NaN	6.78E-02	TRIM28,MAPK10,ATF4,CBX5	
Activation of IRF by Cytosolic Pattern Recognition Receptors	-0E00	NaN	4.84E-02	TRAF3,PPIB,MAPK10	
Acute Myeloid Leukemia Signaling	-0E00	1.0	5.06E-02	KIT,HRAS,MAP2K3,CSF1R	
Allograft Rejection Signaling	-0E00	NaN	5.95E-02	HLA-G,CD28,HLA-A,FCER1G,FAS	
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	-0E00	NaN	7.95E-02	CD28,TRAF3,SPP1,IL1RN,CSF1,FCER1G,FAS	
Androgen Biosynthesis	-0E00	NaN	7.14E-02	AKR1C3,	
Angiopoietin Signaling	-0E00	NaN	3.03E-02	HRAS,TIE1	
Antiproliferative Role of TOB in T Cell Signaling	-0E00	NaN	7.69E-02	PABPC4,TGFB2	
B Cell Development	-0E00	NaN	3.03E-02	PTPRC,	
BMP signaling pathway	-0E00	0.4472135954999579	6.58E-02	FST,PRKACA,MAPK10,HRAS,BMP6	
Bladder Cancer Signaling	-0E00	NaN	6.90E-02	THBS1,MMP14,HRAS,MMP25,MMP9,FGF1	
CD40 Signaling	-0E00	1.3416407864998738	7.69E-02	FOS,TRAF3,MAPK10,MAP2K3,MAPKAPK2	
CNTF Signaling	-0E00	NaN	1.92E-02	HRAS,	
Calcium Signaling	-0E00	2.6457513110645903	7.87E-02	RAP2B,CALR,LETM1,TP63,HDAC2,TPM3,GRINA,MYL9,CALM1 (includes others),MICU1,CAMK2D,PRKACA,ATF4,MYH1	
Cell Cycle Control of Chromosomal Replication	-0E00	NaN	3.70E-02	CDK6,	
Cell Cycle Regulation by BTG Family Proteins	-0E00	NaN	8.57E-02	PPP2R1A,BTG2,PPP2R1B	
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	-0E00	NaN	6.12E-02	YWHAG,YWHAB,TOP2A	
Cholesterol Biosynthesis I	-0E00	NaN	7.69E-02	MSMO1,	
Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)	-0E00	NaN	7.69E-02	MSMO1,	
Cholesterol Biosynthesis III (via Desmosterol)	-0E00	NaN	7.69E-02	MSMO1,	
Chronic Myeloid Leukemia Signaling	-0E00	NaN	8.60E-02	CTBP1,BCL2L1,GAB2,MECOM,HDAC2,TGFB2,CDK6,HRAS	
Cleavage and Polyadenylation of Pre-mRNA	-0E00	NaN	8.33E-02	CSTF3,	
Communication between Innate and Adaptive Immune Cells	-0E00	NaN	7.87E-02	HLA-G,CD28,IL1RN,HLA-A,CD4,FCER1G,CD83	
DNA Double-Strand Break Repair by Non-Homologous End Joining	-0E00	NaN	7.14E-02	XRCC6,	
Death Receptor Signaling	-0E00	2.4494897427831783	6.52E-02	TNFRSF1A,ACTB,CYCS,ACTG1,MAP4K4,FAS	
Endometrial Cancer Signaling	-0E00	NaN	7.69E-02	CTNNA1,HRAS,GSK3B,MLH1	
Ephrin A Signaling	-0E00	NaN	4.17E-02	CFL1,CDC42	
ErbB2-ErbB3 Signaling	-0E00	NaN	5.26E-02	SHC1,HRAS,GSK3B	
Erythropoietin Signaling	-0E00	NaN	7.46E-02	FOS,SOCS3,SHC1,HRAS,PRKCE	
Estrogen-Dependent Breast Cancer Signaling	-0E00	NaN	4.76E-02	FOS,HRAS,ATF4	
Estrogen-mediated S-phase Entry	-0E00	NaN	4.17E-02	ESR2,	
FGF Signaling	-0E00	2.6457513110645903	8.24E-02	MAP3K1,HRAS,ATF4,FGFR2,MAP2K3,MAPKAPK2,FGF1	
FLT3 Signaling in Hematopoietic Progenitor Cells	-0E00	2.0	5.41E-02	SHC1,GAB2,HRAS,ATF4	
Factors Promoting Cardiogenesis in Vertebrates	-0E00	NaN	7.61E-02	LRP6,DVL1,TGFB2,PRKCE,GSK3B,BMP6,ACVR1C	
Fc Epsilon RI Signaling	-0E00	2.23606797749979	4.63E-02	FCER1G,MAPK10,HRAS,PRKCE,MAP2K3	
FcγRIIB Signaling in B Lymphocytes	-0E00	NaN	7.32E-02	SHC1,MAPK10,HRAS	
G-Protein Coupled Receptor Signaling	-0E00	NaN	8.20E-02	PLCB2,ADCY2,NPY1R,CNR1,DUSP6,HRAS,GABBR1,RAPGEF3,SHC1,PLCB4,CAMK2D,ADRA2A,LPAR1,DUSP1,ADCY1,PRKACA,ATF4,PRKCE,P2RY12,DUSP4,ADRA1A	
GM-CSF Signaling	-0E00	2.23606797749979	8.06E-02	BCL2L1,SHC1,CAMK2D,RACK1,HRAS	
Glioblastoma Multiforme Signaling	-0E00	1.507556722888818	8.22E-02	SHC1,PLCB4,PLCB2,RHOG,PLCE1,CDC42,PDGFA,RHOD,CDK6,HRAS,GSK3B,WNT5B	
Glioma Signaling	-0E00	2.6457513110645903	7.14E-02	CALM1 (includes others),SHC1,CAMK2D,PDGFA,CDK6,HRAS,PRKCE	
Glutaryl-CoA Degradation	-0E00	NaN	8.33E-02	HADHB,	
Granulocyte Adhesion and Diapedesis	-0E00	NaN	8.47E-02	FPR3,VCAM1,TNFRSF1A,MMP14,CXCL12,SDC3,SDC4,MMP25,ITGB2,CXCL16,CLDN5,IL1RN,CXCL14,CLDN2,MMP9	
Granzyme B Signaling	-0E00	NaN	6.25E-02	CYCS,	
Growth Hormone Signaling	-0E00	1.0	5.80E-02	FOS,SOCS3,IGFBP3,PRKCE	
Guanosine Nucleotides Degradation III	-0E00	NaN	7.69E-02	AOX1,	
Gustation Pathway	-0E00	NaN	8.26E-02	GNB1,ADCY2,PLCB2,ADCY1,GNG2,PRKACA,P2RY12,P2RY8,GNG5,PANX1	
HER-2 Signaling in Breast Cancer	-0E00	NaN	7.89E-02	ITGB2,CDC42,CDK6,HRAS,PRKCE,GSK3B	
HGF Signaling	-0E00	1.6329931618554523	5.71E-02	FOS,CDC42,MAP3K1,MAPK10,HRAS,PRKCE	
Hematopoiesis from Multipotent Stem Cells	-0E00	NaN	8.33E-02	CSF1,	
Hematopoiesis from Pluripotent Stem Cells	-0E00	NaN	8.51E-02	CD3G,CSF1,CD4,FCER1G	
Hereditary Breast Cancer Signaling	-0E00	NaN	8.53E-02	FANCE,NPM1,HDAC2,ACTB,TUBG1,CDK6,HRAS,POLR2K,HLTF,SMARCA4,MLH1	
Human Embryonic Stem Cell Pluripotency	-0E00	NaN	5.97E-02	NTRK3,PDGFA,DVL1,TGFB2,FGFR2,GSK3B,BMP6,WNT5B	
IL-15 Production	-0E00	NaN	3.70E-02	TWF1,	
IL-15 Signaling	-0E00	NaN	6.35E-02	BCL2L1,SHC1,VCAM1,HRAS	
IL-17 Signaling	-0E00	NaN	8.33E-02	MAPK10,HRAS,MAP2K3,GSK3B,CEBPB,MAPKAPK2	
IL-17A Signaling in Airway Cells	-0E00	NaN	3.12E-02	MAPK10,GSK3B	
IL-17A Signaling in Gastric Cells	-0E00	NaN	8.00E-02	FOS,MAPK10	
IL-2 Signaling	-0E00	NaN	7.55E-02	FOS,SHC1,HRAS,CSNK2B	
IL-22 Signaling	-0E00	NaN	8.33E-02	SOCS3,MAPK10	
IL-3 Signaling	-0E00	NaN	7.04E-02	FOS,SHC1,GAB2,HRAS,PRKCE	
IL-4 Signaling	-0E00	NaN	4.00E-02	SHC1,HRAS,HMGA1	
IL-9 Signaling	-0E00	NaN	2.94E-02	SOCS3,	
Inhibition of Angiogenesis by TSP1	-0E00	NaN	8.82E-02	THBS1,MAPK10,MMP9	
Insulin Receptor Signaling	-0E00	1.8973665961010275	8.33E-02	SOCS3,SHC1,GYS1,PPP1R3C,PRKACA,HRAS,EIF2B3,PPP1R11,GSK3B,STXBP4,PPP1R14B	
Interferon Signaling	-0E00	NaN	2.78E-02	OAS1,	
JAK/Stat Signaling	-0E00	1.6329931618554523	8.33E-02	FOS,SOCS3,BCL2L1,SHC1,HRAS,CEBPB	
Lymphotoxin β Receptor Signaling	-0E00	NaN	7.41E-02	BCL2L1,VCAM1,TRAF3,CYCS	
MIF Regulation of Innate Immunity	-0E00	NaN	7.32E-02	FOS,MAPK10,CD14	
MIF-mediated Glucocorticoid Regulation	-0E00	NaN	3.03E-02	CD14,	
MSP-RON Signaling Pathway	-0E00	NaN	8.70E-02	ITGB2,CSF1,ACTB,ACTG1	
Maturity Onset Diabetes of Young (MODY) Signaling	-0E00	NaN	4.76E-02	GAPDH,	
Melanocyte Development and Pigmentation Signaling	-0E00	1.889822365046136	8.33E-02	SHC1,ADCY2,ADCY1,PRKACA,KIT,HRAS,ATF4	
Melanoma Signaling	-0E00	NaN	2.38E-02	HRAS,	
Melatonin Degradation I	-0E00	NaN	7.02E-02	POR,CYP4B1,B3GAT3,CYP1B1	
Mismatch Repair in Eukaryotes	-0E00	NaN	6.25E-02	MLH1,	
Mitotic Roles of Polo-Like Kinase	-0E00	NaN	6.06E-02	PPP2R1A,HSP90AB1,ANAPC11,PPP2R1B	
Mouse Embryonic Stem Cell Pluripotency	-0E00	0.4472135954999579	5.26E-02	DVL1,HRAS,DVL3,GSK3B,ID4	
NAD Phosphorylation and Dephosphorylation	-0E00	NaN	7.69E-02	ACP2,	
NAD Salvage Pathway II	-0E00	NaN	3.85E-02	ACP2,	
NF-κB Activation by Viruses	-0E00	NaN	8.22E-02	ITGB2,CD4,MAP3K1,ITGAV,HRAS,PRKCE	
NF-κB Signaling	-0E00	2.6726124191242437	8.14E-02	TRAF3,HDAC2,TNFRSF1A,MAP3K1,FGFR2,HRAS,IRAK1,NTRK3,IL1RN,FCER1G,PRKACA,GSK3B,CSNK2B,MAP4K4	
NGF Signaling	-0E00	2.3333333333333335	8.41E-02	SHC1,RHOG,CDC42,MAP3K1,MAPK10,HRAS,ATF4,SMPD2,SMPD3	
Natural Killer Cell Signaling	-0E00	NaN	8.18E-02	SHC1,LAIR1,TYROBP,FCGR2A,KLRD1,FCER1G,HRAS,PRKCE,HCST	
Netrin Signaling	-0E00	NaN	7.69E-02	UNC5B,PRKACA,ENAH	
Neuregulin Signaling	-0E00	1.0	6.82E-02	SHC1,ADAM17,HSP90AB1,ERBB4,HRAS,PRKCE	
Nitric Oxide Signaling in the Cardiovascular System	-0E00	2.0	5.00E-02	CALM1 (includes others),HSP90AB1,PRKACA,SLC7A1,PRKCE	
Non-Small Cell Lung Cancer Signaling	-0E00	NaN	3.08E-02	CDK6,HRAS	
Nucleotide Excision Repair Pathway	-0E00	NaN	8.57E-02	POLR2K,MNAT1,RAD23B	
Oleate Biosynthesis II (Animals)	-0E00	NaN	7.69E-02	SCD,	
Ovarian Cancer Signaling	-0E00	NaN	5.34E-02	DVL1,PRKACA,HRAS,GSK3B,MLH1,WNT5B,MMP9	
PDGF Signaling	-0E00	1.6329931618554523	7.79E-02	FOS,SHC1,PDGFA,MAP3K1,HRAS,CSNK2B	
PEDF Signaling	-0E00	1.0	5.63E-02	BCL2L1,HRAS,TCF7,FAS	
PI3K Signaling in B Lymphocytes	-0E00	-1.507556722888818	8.66E-02	PTPRC,FOS,CALM1 (includes others),PLCB4,PLCB2,CAMK2D,PLCE1,ATF5,HRAS,ATF4,PIK3AP1	
PKCθ Signaling in T Lymphocytes	-0E00	NaN	6.78E-02	CD28,FOS,CD3G,CAMK2D,CD4,MAP3K1,FCER1G,HRAS	
PPARα/RXRα Activation	-0E00	-0.5773502691896258	8.47E-02	PLCB2,ADCY2,ADIPOQ,HRAS,NR2F1,SHC1,PLCB4,PLCE1,HSP90AB1,ADCY1,TGFB2,PRKACA,MAP2K3,MAP4K4,ACVR1C	
PTEN Signaling	-0E00	-1.414213562373095	6.78E-02	BCL2L1,SHC1,NTRK3,CDC42,HRAS,FGFR2,GSK3B,CSNK2B	
Pancreatic Adenocarcinoma Signaling	-0E00	1.889822365046136	7.55E-02	BCL2L1,HMOX1,RALA,PLD3,CDC42,TGFB2,MAPK10,MMP9	
Phototransduction Pathway	-0E00	NaN	3.77E-02	GNB1,PRKACA	
Primary Immunodeficiency Signaling	-0E00	NaN	6.25E-02	PTPRC,CD4,UNG	
Prostate Cancer Signaling	-0E00	NaN	6.10E-02	HSP90AB1,HRAS,ATF4,GSK3B,GSTP1	
Pyridoxal 5'-phosphate Salvage Pathway	-0E00	NaN	7.81E-02	CDK6,PRKCE,MAP2K3,PKN1,IRAK1	
RANK Signaling in Osteoclasts	-0E00	1.0	4.55E-02	FOS,CALM1 (includes others),MAP3K1,MAPK10	
Regulation of the Epithelial-Mesenchymal Transition Pathway	-0E00	NaN	8.15E-02	ADAM17,EGR1,DVL1,HRAS,NCSTN,FGFR2,HIF1A,FGF1,PYGO2,TGFB2,MAP2K3,DVL3,GSK3B,MMP9,WNT5B	
Renin-Angiotensin Signaling	-0E00	1.6666666666666667	8.26E-02	FOS,SHC1,ADCY2,ADCY1,MAP3K1,PRKACA,MAPK10,HRAS,PRKCE	
Retinoic acid Mediated Apoptosis Signaling	-0E00	NaN	1.64E-02	CYCS,	
Retinol Biosynthesis	-0E00	NaN	8.82E-02	CES1,DHRS9,CES2	
Role of BRCA1 in DNA Damage Response	-0E00	NaN	7.69E-02	FANCE,ACTB,RBBP8,HLTF,SMARCA4,MLH1	
Role of CHK Proteins in Cell Cycle Checkpoint Control	-0E00	NaN	5.45E-02	PPP2R1A,ATMIN,PPP2R1B	
Role of Cytokines in Mediating Communication between Immune Cells	-0E00	NaN	1.85E-02	IL1RN,	
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza	-0E00	NaN	2.33E-02	IL1RN,	
Role of IL-17A in Arthritis	-0E00	NaN	5.56E-02	MAPK10,MAP2K3,MAPKAPK2	
Role of IL-17F in Allergic Inflammatory Airway Diseases	-0E00	NaN	2.27E-02	ATF4,	
Role of JAK family kinases in IL-6-type Cytokine Signaling	-0E00	NaN	8.00E-02	SOCS3,MAPK10	
Role of JAK1 and JAK3 in γc Cytokine Signaling	-0E00	NaN	4.84E-02	SOCS3,SHC1,HRAS	
Role of MAPK Signaling in the Pathogenesis of Influenza	-0E00	NaN	5.80E-02	MAPK10,HRAS,RARRES3,MAP2K3	
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency	-0E00	NaN	5.41E-02	SHC1,DVL1,HRAS,GSK3B,BMP6,WNT5B	
Role of PI3K/AKT Signaling in the Pathogenesis of Influenza	-0E00	NaN	3.17E-02	GSK3B,MLH1	
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses	-0E00	1.6329931618554523	8.00E-02	PTX3,OAS1,TGFB2,MAPK10,PRKCE,C1QA,C1QC,C1QB,EIF2S1,C3AR1	
Role of RIG1-like Receptors in Antiviral Innate Immunity	-0E00	NaN	2.33E-02	TRAF3,	
Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza	-0E00	1.0	5.26E-02	DVL1,DVL3,GSK3B,WNT5B	
Role of p14/p19ARF in Tumor Suppression	-0E00	NaN	6.67E-02	NPM1,SENP3	
STAT3 Pathway	-0E00	0.8164965809277261	8.22E-02	SOCS3,NTRK3,MAPK10,HRAS,FGFR2,NDUFA13	
Salvage Pathways of Pyrimidine Ribonucleotides	-0E00	NaN	8.70E-02	NME1,AK1,CDK6,NME2,PRKCE,MAP2K3,PKN1,IRAK1	
Semaphorin Signaling in Neurons	-0E00	NaN	7.55E-02	PLXNA1,RHOG,CFL1,RHOD	
Serotonin Receptor Signaling	-0E00	NaN	6.82E-02	ADCY2,ADCY1,PCBD1	
Small Cell Lung Cancer Signaling	-0E00	NaN	5.63E-02	BCL2L1,TRAF3,CDK6,CYCS	
Sperm Motility	-0E00	1.414213562373095	6.61E-02	CALM1 (includes others),PLCB4,PLCB2,TWF1,PLCE1,PRKACA,PRKCE,RARRES3	
Superpathway of Citrulline Metabolism	-0E00	NaN	7.14E-02	ASS1,	
Superpathway of Melatonin Degradation	-0E00	NaN	6.45E-02	POR,CYP4B1,B3GAT3,CYP1B1	
Synaptic Long Term Depression	-0E00	0.6324555320336759	7.04E-02	PPP2R1A,PLCB4,PLCB2,PLCE1,GNA12,HRAS,PRKCE,RARRES3,GNA13,PPP2R1B	
T Helper Cell Differentiation	-0E00	NaN	5.63E-02	CD28,TNFRSF1A,FCER1G,IL10RA	
TGF-β Signaling	-0E00	0.8164965809277261	6.90E-02	FOS,CDC42,TGFB2,HRAS,MAP2K3,ACVR1C	
TNFR2 Signaling	-0E00	NaN	6.90E-02	FOS,MAP3K1	
TREM1 Signaling	-0E00	NaN	4.00E-02	TYROBP,CD83,IRAK1	
TWEAK Signaling	-0E00	NaN	8.82E-02	TRAF3,CYCS,TNFRSF12A	
Telomerase Signaling	-0E00	0.8164965809277261	8.08E-02	SHC1,PPP2R1A,HSP90AB1,HDAC2,DKC1,HRAS,TPP1,PPP2R1B	
Telomere Extension by Telomerase	-0E00	NaN	6.67E-02	XRCC6,	
The Visual Cycle	-0E00	NaN	6.67E-02	DHRS9,	
Thyroid Hormone Metabolism II (via Conjugation and/or Degradation)	-0E00	NaN	2.86E-02	B3GAT3,	
Triacylglycerol Degradation	-0E00	NaN	8.00E-02	ABHD12,CES1	
Tryptophan Degradation III (Eukaryotic)	-0E00	NaN	4.76E-02	HADHB,	
Tumoricidal Function of Hepatic Natural Killer Cells	-0E00	NaN	8.33E-02	CYCS,FAS	
UVB-Induced MAPK Signaling	-0E00	NaN	5.66E-02	FOS,MAPK10,PRKCE	
VEGF Family Ligand-Receptor Interactions	-0E00	1.0	5.26E-02	FOS,SHC1,HRAS,PRKCE	
cAMP-mediated signaling	-0E00	0.0	7.31E-02	ADCY2,NPY1R,CNR1,DUSP6,GABBR1,RAPGEF3,CALM1 (includes others),CAMK2D,LPAR1,ADRA2A,DUSP1,ADCY1,PRKACA,P2RY12,ATF4,DUSP4	
iCOS-iCOSL Signaling in T Helper Cells	-0E00	2.6457513110645903	8.33E-02	PTPRC,CD28,CD3G,CALM1 (includes others),SHC1,GAB2,CAMK2D,CD4,FCER1G	
tRNA Splicing	-0E00	NaN	2.86E-02	TSEN15,	
Calcium Transport I	2.19E-01	NaN	1.00E-01	ANXA5,	
Embryonic Stem Cell Differentiation into Cardiac Lineages	2.19E-01	NaN	1.00E-01	HOXB5,	
Retinoate Biosynthesis I	2.46E-01	NaN	9.09E-02	DHRS9,AKR1C3,ALDH1A2	
Assembly of RNA Polymerase I Complex	2.48E-01	NaN	1.11E-01	POLR1A,	
Ketolysis	2.48E-01	NaN	1.11E-01	HADHB,	
Phosphatidylethanolamine Biosynthesis II	2.48E-01	NaN	1.11E-01	PCYT2,	
EGF Signaling	2.53E-01	1.3416407864998738	8.93E-02	FOS,SHC1,MAP3K1,HRAS,CSNK2B	
Serotonin Degradation	2.6E-01	NaN	8.96E-02	ALDH1B1,ALDH4A1,DHRS9,ALDH3A2,ALDH1A2,B3GAT3	
Thrombopoietin Signaling	2.66E-01	1.3416407864998738	9.09E-02	FOS,SHC1,GAB2,HRAS,PRKCE	
DNA Methylation and Transcriptional Repression Signaling	2.69E-01	NaN	1.00E-01	HDAC2,MBD3	
Relaxin Signaling	2.71E-01	1.414213562373095	8.89E-02	GNB1,FOS,ADCY2,GNA12,ADCY1,GNG2,RACK1,PRKACA,GNA13,GNG5,GNG12,MMP9	
OX40 Signaling Pathway	2.72E-01	1.6329931618554523	8.99E-02	HLA-G,CD3G,BCL2L1,TRAF3,HLA-A,CD4,FCER1G,MAPK10	
Neuropathic Pain Signaling In Dorsal Horn Neurons	2.77E-01	0.3333333333333333	9.00E-02	TACR1,FOS,PLCB4,PLCB2,CAMK2D,PLCE1,PRKACA,PRKCE,GRINA	
Nicotine Degradation III	2.79E-01	NaN	9.26E-02	POR,CYP4B1,AOX1,B3GAT3,CYP1B1	
Corticotropin Releasing Hormone Signaling	2.81E-01	0.0	9.01E-02	FOS,CALM1 (includes others),ADCY2,CNR1,ADCY1,ARPC5,PRKACA,NR4A1,ATF4,PRKCE	
Airway Pathology in Chronic Obstructive Pulmonary Disease	2.81E-01	NaN	1.25E-01	MMP9,	
Glucose and Glucose-1-phosphate Degradation	2.81E-01	NaN	1.25E-01	HK1,	
Histidine Degradation III	2.81E-01	NaN	1.25E-01	MTHFD1L,	
Purine Ribonucleosides Degradation to Ribose-1-phosphate	2.81E-01	NaN	1.25E-01	CECR1,	
Salvage Pathways of Pyrimidine Deoxyribonucleotides	2.81E-01	NaN	1.25E-01	TYMP,	
GADD45 Signaling	2.92E-01	NaN	1.05E-01	CCND2,CCND3	
FAK Signaling	2.94E-01	NaN	9.20E-02	CAPN6,CAPNS1,TLN2,ACTB,HRAS,CAPN2,ACTG1,TNS1	
Agranulocyte Adhesion and Diapedesis	2.95E-01	NaN	8.99E-02	VCAM1,TNFRSF1A,ACTB,MMP14,CXCL12,SDC4,MMP25,MYL9,ITGB2,CXCL16,CLDN5,IL1RN,CXCL14,CLDN2,ACTG1,MMP9,MYH1	
Eicosanoid Signaling	2.98E-01	NaN	9.38E-02	PTGFR,PTGES2,AKR1C3,ALOX5AP,RARRES3,HPGDS	
Sonic Hedgehog Signaling	2.99E-01	NaN	1.00E-01	GLIS2,PRKACA,GSK3B	
phagosome formation	3.01E-01	NaN	9.17E-02	PLCB4,PLCB2,RHOG,PLCE1,SCARA3,MSR1,FCGR2A,RHOD,FCER1G,PRKCE	
HMGB1 Signaling	3.04E-01	2.1105794120443453	9.17E-02	FOS,VCAM1,RHOG,CDC42,TNFRSF1A,RHOD,TGFB2,MAPK10,HRAS,MAP2K3,PLAT	
HIPPO signaling	3.06E-01	-2.23606797749979	9.30E-02	PPP2R1A,YWHAG,YWHAB,PPP1R3C,PPP1R11,PPP1R14B,AMOT,PPP2R1B	
Heparan Sulfate Biosynthesis (Late Stages)	3.09E-01	NaN	9.62E-02	CHST2,HS6ST1,UST,HS2ST1,CHST11	
Antiproliferative Role of Somatostatin Receptor 2	3.12E-01	2.0	9.52E-02	GNB1,GNG2,RACK1,HRAS,GNG5,GNG12	
Nicotine Degradation II	3.12E-01	NaN	9.52E-02	POR,CYP4B1,FMO1,AOX1,B3GAT3,CYP1B1	
Phosphatidylglycerol Biosynthesis II (Non-plastidic)	3.18E-01	NaN	1.11E-01	LPCAT4,AGPAT1	
Adenine and Adenosine Salvage III	3.22E-01	NaN	1.43E-01	CECR1,	
GDP-glucose Biosynthesis	3.22E-01	NaN	1.43E-01	HK1,	
B Cell Activating Factor Signaling	3.22E-01	NaN	1.00E-01	FOS,TRAF3,MAP3K1,MAPK10	
Thyroid Cancer Signaling	3.22E-01	NaN	1.00E-01	SHC1,NTRK3,HRAS,RET	
LPS-stimulated MAPK Signaling	3.29E-01	1.889822365046136	9.59E-02	FOS,CDC42,MAPK10,HRAS,CD14,PRKCE,MAP2K3	
Prolactin Signaling	3.29E-01	1.6329931618554523	9.59E-02	FOS,SOCS3,SHC1,HRAS,PRKCE,CEBPB,TCF7	
CCR3 Signaling in Eosinophils	3.36E-01	NaN	9.40E-02	GNB1,CALM1 (includes others),PLCB4,PLCB2,CFL1,GNG2,RACK1,HRAS,PRKCE,GNG5,GNG12	
Docosahexaenoic Acid (DHA) Signaling	3.41E-01	NaN	1.03E-01	BCL2L1,CYCS,GSK3B,APP	
Assembly of RNA Polymerase II Complex	3.41E-01	NaN	1.00E-01	TAF6,POLR2K,TAF10,MNAT1,TAF13	
Basal Cell Carcinoma Signaling	3.42E-01	1.1338934190276817	9.72E-02	KIF7,GLIS2,DVL1,DVL3,GSK3B,BMP6,WNT5B	
Endothelin-1 Signaling	3.43E-01	2.0	9.30E-02	PLCB2,ADCY2,PLD3,EDNRB,GNA12,HRAS,FOS,SHC1,HMOX1,PLCB4,PLCE1,ADCY1,MAPK10,RARRES3,PRKCE,GNA13	
Adenosine Nucleotides Degradation II	3.46E-01	NaN	1.18E-01	CECR1,AOX1	
GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell	3.57E-01	NaN	9.86E-02	ADCY2,PLCB4,PLCB2,PLCE1,ADCY1,PRKACA,ADCYAP1	
ErbB4 Signaling	3.57E-01	1.3416407864998738	1.00E-01	SHC1,ADAM17,ERBB4,HRAS,NCSTN,PRKCE	
Rac Signaling	3.57E-01	3.162277660168379	9.62E-02	ACTR3,CFL1,ARPC1B,CDC42,ARPC5L,MAP3K1,ARPC5,CYBB,HRAS,ARPC4	
TNFR1 Signaling	3.58E-01	1.3416407864998738	1.02E-01	FOS,CDC42,TNFRSF1A,MAP3K1,CYCS	
April Mediated Signaling	3.6E-01	1.0	1.05E-01	FOS,TRAF3,MAP3K1,MAPK10	
Estrogen Biosynthesis	3.6E-01	NaN	1.05E-01	POR,AKR1C3,CYP4B1,CYP1B1	
Acetone Degradation I (to Methylglyoxal)	3.65E-01	NaN	1.11E-01	POR,CYP4B1,CYP1B1	
Arginine Biosynthesis IV	3.7E-01	NaN	1.67E-01	ASS1,	
Glycine Cleavage Complex	3.7E-01	NaN	1.67E-01	GCSH,	
Rapoport-Luebering Glycolytic Shunt	3.7E-01	NaN	1.67E-01	PGAM1,	
UDP-N-acetyl-D-glucosamine Biosynthesis II	3.7E-01	NaN	1.67E-01	GFPT1,	
Urea Cycle	3.7E-01	NaN	1.67E-01	ASS1,	
Zymosterol Biosynthesis	3.7E-01	NaN	1.67E-01	MSMO1,	
Chondroitin Sulfate Biosynthesis (Late Stages)	3.76E-01	NaN	1.04E-01	CHST2,HS6ST1,UST,HS2ST1,CHST11	
CDP-diacylglycerol Biosynthesis I	3.77E-01	NaN	1.25E-01	LPCAT4,AGPAT1	
Phospholipases	3.9E-01	NaN	1.03E-01	HMOX1,PLCB4,PLCB2,PLCE1,PLD3,RARRES3	
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes	4E-01	NaN	1.01E-01	CD28,FOS,CD3G,CALM1 (includes others),MAP3K1,TGFB2,MAPK10,HRAS	
Dendritic Cell Maturation	4.01E-01	2.32379000772445	9.60E-02	PLCB2,LEP,TYROBP,TNFRSF1A,HLA-A,FCGR2A,CD83,COL5A3,PLCB4,PLCE1,IL1RN,TREM2,FSCN1,FCER1G,MAPK10,ATF4,IRF8	
GDNF Family Ligand-Receptor Interactions	4.03E-01	NaN	1.03E-01	DOK5,FOS,SHC1,CDC42,MAPK10,HRAS,RET	
autophagy	4.03E-01	NaN	1.11E-01	LAMP2,ATG9A,SQSTM1,VPS11	
Cardiac β-adrenergic Signaling	4.04E-01	-1.414213562373095	9.77E-02	GNB1,PPP2R1A,ADCY2,PPP1R3C,ADCY1,GNG2,RACK1,PRKACA,PPP1R11,GNG5,PPP1R14B,PPP2R1B,GNG12	
IL-12 Signaling and Production in Macrophages	4.04E-01	NaN	9.77E-02	APOE,APOB,MAF,RAB7A,CEBPB,FOS,LYZ,APOC1,MAPK10,TGFB2,PRKCE,SERPINA1,IRF8	
Glioma Invasiveness Signaling	4.08E-01	2.4494897427831783	1.05E-01	RHOG,RHOD,ITGAV,HRAS,PLAU,MMP9	
Leukocyte Extravasation Signaling	4.1E-01	2.0	9.60E-02	VCAM1,ACTB,MMP14,CXCL12,CTNNA1,RAPGEF3,MMP25,ITGB2,CLDN5,EDIL3,CDC42,MAPK10,CYBB,ARHGAP35,PRKCE,CLDN2,ACTG1,MMP9,ACTN1	
Vitamin-C Transport	4.12E-01	NaN	1.33E-01	TXN,TXNRD1	
nNOS Signaling in Skeletal Muscle Cells	4.12E-01	NaN	1.33E-01	CALM1 (includes others),SNTB1	
Cyclins and Cell Cycle Regulation	4.15E-01	-0.3779644730092272	1.03E-01	PPP2R1A,CCND2,CCND3,HDAC2,TGFB2,CDK6,GSK3B,PPP2R1B	
Dermatan Sulfate Biosynthesis (Late Stages)	4.15E-01	NaN	1.09E-01	CHST2,HS6ST1,UST,HS2ST1,CHST11	
Bupropion Degradation	4.17E-01	NaN	1.20E-01	POR,CYP4B1,CYP1B1	
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis	4.19E-01	NaN	9.59E-02	ADAM17,SPP1,SFRP2,TNFRSF1A,MMP14,DVL1,LRP6,CSF1R,FOS,CALM1 (includes others),IL1RN,DKK3,CSF1,MAPK10,MAP2K3,GSK3B,SFRP1,BMP6,ADAMTS5,ALPL,WNT5B	
GABA Receptor Signaling	4.2E-01	NaN	1.04E-01	ADCY2,UBQLN1,ADCY1,GABBR1,AP1B1,GABARAP,AP2S1	
Neurotrophin/TRK Signaling	4.2E-01	1.6329931618554523	1.04E-01	FOS,SHC1,NTRK3,CDC42,HRAS,ATF4,MAP2K3	
Antioxidant Action of Vitamin C	4.23E-01	-1.1338934190276817	1.01E-01	SLC2A5,HMOX1,PLCB4,PLCB2,PLCE1,PLD3,MAPK10,RARRES3,TXN,TXNRD1	
CTLA4 Signaling in Cytotoxic T Lymphocytes	4.26E-01	NaN	1.02E-01	CD28,CD3G,PPP2R1A,HLA-A,CLTC,FCER1G,AP1B1,PPP2R1B,AP2S1	
IL-17A Signaling in Fibroblasts	4.26E-01	NaN	1.14E-01	FOS,GSK3B,CEBPB,NFKBIZ	
2-oxobutanoate Degradation I	4.31E-01	NaN	2.00E-01	PCCB,	
Ceramide Biosynthesis	4.31E-01	NaN	2.00E-01	SPTLC3,	
Citrulline-Nitric Oxide Cycle	4.31E-01	NaN	2.00E-01	ASS1,	
Creatine-phosphate Biosynthesis	4.31E-01	NaN	2.00E-01	MAP4K4,	
Lactose Degradation III	4.31E-01	NaN	2.00E-01	GLB1,	
Lysine Degradation V	4.31E-01	NaN	2.00E-01	AASDHPPT,	
Serine Biosynthesis	4.31E-01	NaN	2.00E-01	PSAT1,	
Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate	4.31E-01	NaN	2.00E-01	MTHFD1L,	
dTMP De Novo Biosynthesis	4.31E-01	NaN	2.00E-01	SHMT2,	
Gαs Signaling	4.33E-01	1.0	1.01E-01	GNB1,ADCY2,CNR1,ADCY1,GNG2,RACK1,PRKACA,ATF4,RAPGEF3,GNG5,GNG12	
Amyotrophic Lateral Sclerosis Signaling	4.37E-01	NaN	1.02E-01	BCL2L1,CAPN6,CAPNS1,RAB5C,GLUL,CYCS,CAPN2,SOD1,SSR4,GRINA	
Urate Biosynthesis/Inosine 5'-phosphate Degradation	4.5E-01	NaN	1.43E-01	IMPDH2,AOX1	
γ-glutamyl Cycle	4.5E-01	NaN	1.43E-01	GCLM,GSS	
Oncostatin M Signaling	4.51E-01	2.0	1.18E-01	SHC1,HRAS,PLAU,CHI3L1	
T Cell Receptor Signaling	4.51E-01	NaN	1.03E-01	PTPRC,CD28,FOS,CD3G,CALM1 (includes others),SHB,CD4,PAG1,MAP3K1,HRAS	
Dopamine-DARPP32 Feedback in cAMP Signaling	4.57E-01	0.2773500981126146	9.94E-02	PLCB2,ADCY2,PPP1R1B,PPP1R3C,PPP1R11,PPP1R14B,GRINA,CALM1 (includes others),PPP2R1A,PLCB4,PLCE1,ADCY1,PRKACA,ATF4,PRKCE,PPP2R1B	
ErbB Signaling	4.57E-01	NaN	1.05E-01	FOS,SHC1,CDC42,ERBB4,MAPK10,HRAS,PRKCE,MAP2K3,GSK3B	
iNOS Signaling	4.58E-01	NaN	1.14E-01	FOS,CALM1 (includes others),CD14,HMGA1,IRAK1	
Cell Cycle: G1/S Checkpoint Regulation	4.74E-01	-0.8164965809277261	1.09E-01	CCND2,CCND3,HDAC2,TGFB2,CDK6,GNL3,GSK3B	
Leptin Signaling in Obesity	4.82E-01	NaN	1.08E-01	SOCS3,ADCY2,PLCB4,PLCB2,PLCE1,LEP,ADCY1,PRKACA	
Toll-like Receptor Signaling	4.82E-01	2.4494897427831783	1.08E-01	FOS,TOLLIP,IL1RN,MAP3K1,CD14,MAP2K3,MAP4K4,IRAK1	
Acute Phase Response Signaling	4.89E-01	2.138089935299395	1.01E-01	SOCS3,TNFRSF1A,MAP3K1,HRAS,CEBPB,SAA2,HNRNPK,IRAK1,FOS,SHC1,HMOX1,FTL,F8,IL1RN,SAA1,SERPINA1,MAP2K3	
Wnt/β-catenin Signaling	4.89E-01	1.2909944487358056	1.01E-01	SFRP2,DVL1,LRP6,SOX17,PPP2R1A,NLK,DKK3,TGFB2,NR5A2,DVL3,SOX9,GSK3B,CSNK2B,SFRP1,PPP2R1B,ACVR1C,WNT5B	
ERK5 Signaling	4.93E-01	1.3416407864998738	1.11E-01	FOS,YWHAG,YWHAB,GNA12,HRAS,ATF4,GNA13	
Choline Biosynthesis III	4.93E-01	NaN	1.54E-01	HMOX1,PLD3	
Tec Kinase Signaling	5.05E-01	2.3333333333333335	1.02E-01	ACTB,GNA12,RACK1,GNG2,FAS,GNB1,FOS,RHOG,RHOD,FCER1G,MAPK10,PRKCE,GNA13,GNG5,ACTG1,GNG12	
CD27 Signaling in Lymphocytes	5.09E-01	0.8164965809277261	1.15E-01	FOS,BCL2L1,MAP3K1,MAPK10,CYCS,MAP2K3	
2-ketoglutarate Dehydrogenase Complex	5.09E-01	NaN	2.50E-01	OGDH,	
Acetate Conversion to Acetyl-CoA	5.09E-01	NaN	2.50E-01	ACSS3,	
Arginine Degradation I (Arginase Pathway)	5.09E-01	NaN	2.50E-01	ALDH4A1,	
Arsenate Detoxification I (Glutaredoxin)	5.09E-01	NaN	2.50E-01	GLRX2,	
Glutathione Redox Reactions II	5.09E-01	NaN	2.50E-01	TXNDC12,	
Heme Biosynthesis from Uroporphyrinogen-III I	5.09E-01	NaN	2.50E-01	FECH,	
Heme Degradation	5.09E-01	NaN	2.50E-01	HMOX1,	
L-cysteine Degradation I	5.09E-01	NaN	2.50E-01	GOT1,	
Methylmalonyl Pathway	5.09E-01	NaN	2.50E-01	PCCB,	
N-acetylglucosamine Degradation II	5.09E-01	NaN	2.50E-01	GNPDA1,	
Pentose Phosphate Pathway (Oxidative Branch)	5.09E-01	NaN	2.50E-01	PGD,	
Phenylalanine Degradation I (Aerobic)	5.09E-01	NaN	2.50E-01	PCBD1,	
Phenylethylamine Degradation I	5.09E-01	NaN	2.50E-01	ALDH3A2,	
α-tocopherol Degradation	5.09E-01	NaN	2.50E-01	CYP4A11,	
3-phosphoinositide Biosynthesis	5.17E-01	NaN	1.03E-01	SOCS3,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,PPP1R16B,PDXP,DUSP1,DUSP10,MTMR2,ALPL,SIRPA,PI4KB	
ERK/MAPK Signaling	5.29E-01	-0.24253562503633297	1.02E-01	YWHAG,YWHAB,PPP1R3C,DUSP6,HRAS,RAPGEF3,PPP1R11,MKNK2,PPP1R14B,FOS,SHC1,PPP2R1A,TLN2,DUSP1,PRKACA,ATF4,PRKCE,DUSP4,PPP2R1B	
Adipogenesis pathway	5.29E-01	NaN	1.04E-01	LEP,PLIN1,HDAC2,DDIT3,TNFRSF1A,FGFR2,HIF1A,CEBPB,MNAT1,FGF1,CTBP1,SREBF1,SOX9,TCF7	
PI3K/AKT Signaling	5.36E-01	1.2649110640673518	1.06E-01	BCL2L1,SHC1,GAB2,PPP2R1A,GYS1,YWHAG,HSP90AB1,YWHAB,LIMS1,GDF15,HRAS,GSK3B,PPP2R1B	
HIF1α Signaling	5.38E-01	NaN	1.08E-01	SLC2A5,RBX1,MMP14,MAPK10,EGLN3,HRAS,HIF1A,TCEB2,MMP25,NAA10,MMP9	
Chemokine Signaling	5.38E-01	0.7071067811865475	1.13E-01	FOS,CALM1 (includes others),PLCB4,PLCB2,CAMK2D,CFL1,CXCL12,HRAS	
Renal Cell Carcinoma Signaling	5.38E-01	NaN	1.13E-01	FOS,CDC42,RBX1,EGLN3,HRAS,HIF1A,TCEB2,FH	
Role of PKR in Interferon Induction and Antiviral Response	5.58E-01	NaN	1.25E-01	TRAF3,TNFRSF1A,CYCS,MAP2K3,EIF2S1	
Melatonin Signaling	5.58E-01	0.7071067811865475	1.14E-01	CALM1 (includes others),PLCB4,PLCB2,CAMK2D,PLCE1,PRKACA,PRKCE,MAP2K3	
eNOS Signaling	5.64E-01	-0.8320502943378437	1.06E-01	ADCY2,HSPA9,SLC7A1,HSPA5,HSPA2,HSPA8,CALM1 (includes others),HSPA4,HSP90AB1,LPAR1,STUB1,ADCY1,PRKACA,PRKCE,ESR2	
Pyrimidine Ribonucleotides De Novo Biosynthesis	5.66E-01	NaN	1.33E-01	NME1,AK1,NME2,CTPS1	
Role of Tissue Factor in Cancer	5.77E-01	NaN	1.09E-01	BCL2L1,CTGF,CFL1,CDC42,PDXP,CSF1,EGR1,GNA12,ITGAV,HRAS,GNA13,CYR61	
Colorectal Cancer Metastasis Signaling	5.77E-01	2.23606797749979	1.02E-01	ADCY2,TNFRSF1A,MMP14,GNG2,DVL1,LRP6,RACK1,HRAS,MMP25,MLH1,GNB1,FOS,BCL2L1,RHOG,RHOD,ADCY1,TGFB2,PRKACA,MAPK10,GSK3B,GNG5,GNG12,MMP9,WNT5B	
Apoptosis Signaling	5.85E-01	1.0	1.12E-01	BCL2L1,CAPN6,CAPNS1,TNFRSF1A,HRAS,PRKCE,CYCS,CAPN2,MAP4K4,FAS	
PAK Signaling	5.85E-01	3.0	1.12E-01	MYL9,SHC1,CFL1,CDC42,PDGFA,MAPK10,EPHB3,HRAS,MYL12B,MYL12A	
Inhibition of Matrix Metalloproteases	5.86E-01	NaN	1.28E-01	ADAM17,ADAM12,MMP14,MMP25,MMP9	
Granzyme A Signaling	5.89E-01	NaN	1.50E-01	NME1,HIST1H1E,H1F0	
Purine Nucleotides Degradation II (Aerobic)	5.89E-01	NaN	1.50E-01	CECR1,IMPDH2,AOX1	
Sphingosine-1-phosphate Signaling	5.94E-01	1.1547005383792517	1.10E-01	ADCY2,PLCB4,PLCB2,RHOG,PLCE1,PDGFA,RHOD,GNA12,ADCY1,GNA13,SMPD2,SMPD3	
Glycogen Degradation II	5.96E-01	NaN	1.82E-01	TYMP,PYGB	
Role of NFAT in Regulation of the Immune Response	5.98E-01	1.386750490563073	1.05E-01	PLCB2,FCGR2A,CD4,GNA12,RACK1,GNG2,HRAS,GNB1,CD28,FOS,CALM1 (includes others),CD3G,PLCB4,FCER1G,GSK3B,GNA13,GNG5,GNG12	
p70S6K Signaling	5.98E-01	0.30151134457776363	1.09E-01	PLCB2,YWHAG,F2RL3,YWHAB,HRAS,SHC1,PLCB4,PPP2R1A,PLCE1,MAPT,PRKCE,BCAP31,PPP2R1B	
Intrinsic Prothrombin Activation Pathway	6E-01	0.0	1.38E-01	COL5A3,F8,F5,F13A1	
Myc Mediated Apoptosis Signaling	6.02E-01	NaN	1.21E-01	SHC1,YWHAG,YWHAB,MAPK10,HRAS,CYCS,FAS	
UVA-Induced MAPK Signaling	6.04E-01	0.3779644730092272	1.14E-01	FOS,BCL2L1,PLCB4,PLCB2,PLCE1,MAPK10,HRAS,CYCS,SMPD2,SMPD3	
Graft-versus-Host Disease Signaling	6.06E-01	NaN	1.25E-01	HLA-G,CD28,IL1RN,HLA-A,FCER1G,FAS	
p53 Signaling	6.07E-01	-0.3333333333333333	1.12E-01	SCO2,BCL2L1,TP63,CCND2,THBS1,RRM2B,GNL3,GSK3B,HIF1A,FAS,SERPINE2	
1,25-dihydroxyvitamin D3 Biosynthesis	6.15E-01	NaN	3.33E-01	POR,	
5-aminoimidazole Ribonucleotide Biosynthesis I	6.15E-01	NaN	3.33E-01	PPAT,	
Aspartate Biosynthesis	6.15E-01	NaN	3.33E-01	GOT1,	
Biotin-carboxyl Carrier Protein Assembly	6.15E-01	NaN	3.33E-01	HLCS,	
D-glucuronate Degradation I	6.15E-01	NaN	3.33E-01	DCXR,	
Glutamate Degradation II	6.15E-01	NaN	3.33E-01	GOT1,	
Hypusine Biosynthesis	6.15E-01	NaN	3.33E-01	EIF5A,	
L-serine Degradation	6.15E-01	NaN	3.33E-01	SRR,	
Methionine Salvage II (Mammalian)	6.15E-01	NaN	3.33E-01	BHMT2,	
N-acetylglucosamine Degradation I	6.15E-01	NaN	3.33E-01	GNPDA1,	
S-adenosyl-L-methionine Biosynthesis	6.15E-01	NaN	3.33E-01	MAT2A,	
Trehalose Degradation II (Trehalase)	6.15E-01	NaN	3.33E-01	HK1,	
Tyrosine Biosynthesis IV	6.15E-01	NaN	3.33E-01	PCBD1,	
Notch Signaling	6.16E-01	0.0	1.32E-01	ADAM17,DTX4,NCSTN,LFNG,RFNG	
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	6.18E-01	NaN	1.01E-01	SOCS3,TRAF3,PLCB2,SFRP2,PDGFA,LRP6,CXCL12,HRAS,CEBPG,IRAK1,CAMK2D,NLK,PLCE1,DKK3,PRKCE,ATF4,GSK3B,MAPKAPK2,WNT5B,VCAM1,TNFRSF1A,DVL1,CEBPB,FOS,CALM1 (includes others),PLCB4,CSF1,IL1RN,MAP2K3,SFRP1	
Nur77 Signaling in T Lymphocytes	6.26E-01	NaN	1.23E-01	CD28,CD3G,CALM1 (includes others),HDAC2,FCER1G,NR4A1,CYCS	
Regulation of Cellular Mechanics by Calpain Protease	6.26E-01	2.0	1.23E-01	CAPN6,CAPNS1,TLN2,CDK6,HRAS,CAPN2,ACTN1	
Autoimmune Thyroid Disease Signaling	6.33E-01	NaN	1.28E-01	HLA-G,CD28,HLA-A,FCER1G,TPO,FAS	
nNOS Signaling in Neurons	6.33E-01	NaN	1.28E-01	CALM1 (includes others),CAPN6,CAPNS1,PRKCE,CAPN2,GRINA	
Pyrimidine Ribonucleotides Interconversion	6.35E-01	NaN	1.43E-01	NME1,AK1,NME2,CTPS1	
Gαq Signaling	6.45E-01	2.6726124191242437	1.09E-01	PLCB2,PLD3,GNG2,RACK1,GNB1,HMOX1,CALM1 (includes others),PLCB4,RHOG,GYS1,RHOD,PRKCE,GSK3B,GNG5,ADRA1A,GNG12	
PXR/RXR Activation	6.46E-01	NaN	1.21E-01	SCD,PCK2,ALDH3A2,PRKACA,ABCB11,ALAS1,CES2,ABCC3	
Antigen Presentation Pathway	6.47E-01	NaN	1.35E-01	HLA-G,CALR,PSMB5,HLA-A,PSMB6	
IL-6 Signaling	6.49E-01	2.3094010767585034	1.12E-01	SOCS3,TNFRSF1A,HRAS,CEBPB,SHC1,FOS,IL1RN,MAPK10,CD14,MAP2K3,CSNK2B,MAPKAPK2,MAP4K4	
Ketogenesis	6.59E-01	NaN	2.00E-01	HADHB,HMGCS1	
3-phosphoinositide Degradation	6.6E-01	NaN	1.10E-01	SOCS3,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,INPP4B,PPP1R16B,PDXP,DUSP1,DUSP10,MTMR2,ALPL,SIRPA	
Valine Degradation I	6.8E-01	NaN	1.67E-01	BCAT1,HADHB,ACAD8	
Gap Junction Signaling	6.8E-01	NaN	1.10E-01	TUBA1B,PLCB2,ADCY2,TUBB4B,ACTB,TUBG1,TUBB2A,HRAS,TUBB,PLCB4,PLCE1,LPAR1,ADCY1,PRKACA,PRKCE,TUBA1C,ACTG1	
GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells	6.86E-01	NaN	1.19E-01	ADCY2,PLCB4,PLCB2,PLCE1,ADCY1,GNG2,PRKACA,PRKCE,GNG5,GNG12	
Calcium-induced T Lymphocyte Apoptosis	6.95E-01	0.8164965809277261	1.25E-01	CD3G,CALM1 (includes others),HDAC2,CD4,FCER1G,NR4A1,PRKCE,CAPN2	
B Cell Receptor Signaling	7.03E-01	3.0	1.09E-01	RAP2B,GAB2,CFL1,FCGR2A,EGR1,MAP3K1,HRAS,PAX5,PTPRC,SHC1,BCL2L1,CALM1 (includes others),CAMK2D,CDC42,PAG1,ATF4,MAP2K3,PIK3AP1,GSK3B	
D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis	7.14E-01	NaN	1.54E-01	PLCB4,PLCB2,PLCE1,PI4KB	
Triacylglycerol Biosynthesis	7.14E-01	NaN	1.43E-01	LPCAT4,DGAT2,AGPAT1,ELOVL1,LPIN2	
Systemic Lupus Erythematosus Signaling	7.2E-01	NaN	1.07E-01	PRPF19,HLA-A,FCGR2A,SNRPF,TXNL4A,HRAS,PTPRC,HLA-G,CD28,FOS,CD3G,LSM12,IL1RN,SNRNP25,FCER1G,LSM1,SNRPD1,LSM3,SNU13,SNRPD3,SNRPD2,C6,LSM4	
Superpathway of Inositol Phosphate Compounds	7.26E-01	NaN	1.09E-01	SOCS3,PLCB2,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,PLCB4,PLCE1,IP6K3,DUSP1,PDXP,PPP1R16B,DUSP10,MTMR2,ALPL,SIRPA,PI4KB,PPIP5K2	
VEGF Signaling	7.26E-01	2.6457513110645903	1.20E-01	BCL2L1,SHC1,ACTB,HRAS,EIF2B3,HIF1A,EIF2S1,ACTG1,EIF2S2,EIF1AY,ACTN1	
Folate Transformations I	7.31E-01	NaN	2.22E-01	MTHFD1L,SHMT2	
Leucine Degradation I	7.31E-01	NaN	2.22E-01	BCAT1,IVD	
Prostanoid Biosynthesis	7.31E-01	NaN	2.22E-01	PTGES2,HPGDS	
Sucrose Degradation V (Mammalian)	7.31E-01	NaN	2.22E-01	ALDOA,ALDOC	
UDP-N-acetyl-D-galactosamine Biosynthesis II	7.31E-01	NaN	2.22E-01	HK1,GNPDA1	
Dermatan Sulfate Degradation (Metazoa)	7.31E-01	NaN	1.76E-01	GM2A,HYAL1,HEXA	
Mitochondrial L-carnitine Shuttle Pathway	7.31E-01	NaN	1.76E-01	ACSL3,SLC27A3,SLC27A4	
γ-linolenate Biosynthesis II (Animals)	7.31E-01	NaN	1.76E-01	ACSL3,SLC27A3,SLC27A4	
Paxillin Signaling	7.44E-01	3.0	1.19E-01	ITGB2,ARF6,TLN2,CDC42,ARF1,ACTB,ITGA8,MAPK10,ITGAV,HRAS,ACTG1,ACTN1	
Hepatic Cholestasis	7.47E-01	NaN	1.12E-01	ADCY2,SLC4A2,CYP27A1,TNFRSF1A,NR1H3,IRAK1,SREBF1,IL1RN,ABCC1,ADCY1,TGFB2,PRKACA,MAPK10,NR5A2,PRKCE,CD14,ABCB11,ABCC3	
Role of JAK2 in Hormone-like Cytokine Signaling	7.51E-01	NaN	1.47E-01	SOCS3,SHC1,SH2B3,HLTF,SIRPA	
Type I Diabetes Mellitus Signaling	7.63E-01	3.0	1.18E-01	SOCS3,HLA-A,TNFRSF1A,HSPD1,FAS,IRAK1,HLA-G,CD3G,CD28,MAPK10,FCER1G,CYCS,MAP2K3	
Adenine and Adenosine Salvage I	7.72E-01	NaN	5.00E-01	APRT,	
Glycine Biosynthesis I	7.72E-01	NaN	5.00E-01	SHMT2,	
L-DOPA Degradation	7.72E-01	NaN	5.00E-01	COMT,	
L-cysteine Degradation III	7.72E-01	NaN	5.00E-01	GOT1,	
Lipoate Biosynthesis and Incorporation II	7.72E-01	NaN	5.00E-01	LIAS,	
Proline Degradation	7.72E-01	NaN	5.00E-01	ALDH4A1,	
Putrescine Biosynthesis III	7.72E-01	NaN	5.00E-01	ODC1,	
Spermidine Biosynthesis I	7.72E-01	NaN	5.00E-01	SRM,	
UDP-D-xylose and UDP-D-glucuronate Biosynthesis	7.72E-01	NaN	5.00E-01	UXS1,	
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis	7.79E-01	NaN	1.16E-01	SOCS3,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,PPP1R16B,PDXP,DUSP1,DUSP10,MTMR2,ALPL,SIRPA	
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis	7.79E-01	NaN	1.16E-01	SOCS3,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,PPP1R16B,PDXP,DUSP1,DUSP10,MTMR2,ALPL,SIRPA	
GNRH Signaling	7.79E-01	1.8073922282301278	1.16E-01	PLCB2,ADCY2,EGR1,MAP3K1,HRAS,FOS,PLCB4,CAMK2D,CDC42,ADCY1,PRKACA,MAPK10,PRKCE,ATF4,MAP2K3	
Chondroitin Sulfate Degradation (Metazoa)	7.88E-01	NaN	1.88E-01	GM2A,HYAL1,HEXA	
Extrinsic Prothrombin Activation Pathway	7.88E-01	NaN	1.88E-01	F5,F13A1,TFPI	
Parkinson's Signaling	7.88E-01	NaN	1.88E-01	UCHL1,PARK7,CYCS	
UVC-Induced MAPK Signaling	7.89E-01	0.8164965809277261	1.43E-01	FOS,MAPK10,HRAS,PRKCE,SMPD2,SMPD3	
Induction of Apoptosis by HIV1	8.03E-01	2.1213203435596424	1.33E-01	BCL2L1,SLC25A13,SLC25A6,TNFRSF1A,MAPK10,CYCS,SLC25A5,FAS	
Agrin Interactions at Neuromuscular Junction	8.15E-01	1.889822365046136	1.30E-01	ITGB2,CDC42,ACTB,ERBB4,LAMA2,DVL1,MAPK10,HRAS,ACTG1	
Sphingomyelin Metabolism	8.15E-01	NaN	2.50E-01	SMPD2,SMPD3	
Cdc42 Signaling	8.15E-01	3.3565855667130946	1.14E-01	RALA,CFL1,ARPC1B,ARPC5L,HLA-A,ARPC5,CLIP1,HLA-G,MYL9,FOS,CD3G,ACTR3,CDC42,FCER1G,MAPK10,GSK3B,MYL12B,ARPC4,MYL12A	
Tight Junction Signaling	8.15E-01	NaN	1.14E-01	TNFRSF1A,ACTB,VAPA,CTNNA1,CASK,GPAA1,MYL9,FOS,PPP2R1A,CLDN5,CDC42,TGFB2,PRKACA,CLDN2,ARHGEF2,ACTG1,PPP2R1B,CSTF3,MYH1	
Gα12/13 Signaling	8.21E-01	2.6726124191242437	1.20E-01	CDH18,F2RL3,GNA12,MAP3K1,HRAS,CDH11,MYL9,LPAR1,CDC42,CDH20,MAPK10,GNA13,MYL12B,MYL12A	
p38 MAPK Signaling	8.21E-01	3.05085107923876	1.20E-01	DDIT3,TNFRSF1A,HMGN1,MKNK2,FAS,IRAK1,DUSP1,IL1RN,DUSP10,MAPT,TGFB2,ATF4,MAP2K3,MAPKAPK2	
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells	8.3E-01	2.0	1.56E-01	CD3G,HLA-A,FCER1G,CYCS,FAS	
Fatty Acid β-oxidation I	8.3E-01	NaN	1.56E-01	ACSL3,HADHB,SLC27A3,IVD,SLC27A4	
Dermatan Sulfate Biosynthesis	8.33E-01	NaN	1.36E-01	CHST2,HS6ST1,B3GALT6,UST,XYLT1,HS2ST1,CHST11,B3GAT3	
Heparan Sulfate Biosynthesis	8.33E-01	NaN	1.36E-01	CHST2,HS6ST1,B3GALT6,UST,XYLT1,HS2ST1,CHST11,B3GAT3	
Type II Diabetes Mellitus Signaling	8.42E-01	0.8164965809277261	1.21E-01	SOCS3,ACSL3,TNFRSF1A,PKM,MAP3K1,ADIPOQ,CEBPB,SMPD2,SLC27A4,MAPK10,PRKCE,SLC27A3,NSMAF,SMPD3	
IL-10 Signaling	8.42E-01	NaN	1.32E-01	FOS,SOCS3,HMOX1,IL1RN,FCGR2A,IL10RA,CD14,MAP2K3,MAP4K4	
Macropinocytosis Signaling	8.42E-01	2.4494897427831783	1.32E-01	ITGB2,ARF6,CDC42,PDGFA,CSF1,HRAS,CD14,PRKCE,CSF1R	
Tryptophan Degradation X (Mammalian, via Tryptamine)	8.53E-01	NaN	1.74E-01	ALDH1B1,ALDH4A1,ALDH3A2,ALDH1A2	
Neuroprotective Role of THOP1 in Alzheimer's Disease	8.61E-01	NaN	1.50E-01	HLA-G,HLA-A,MAPT,PRKACA,MMP9,APP	
Glutamate Receptor Signaling	8.95E-01	NaN	1.40E-01	GNB1,CALM1 (includes others),SLC1A4,GNG2,GLUL,SLC38A1,GNG5,GRINA	
Molecular Mechanisms of Cancer	9.05E-01	NaN	1.07E-01	RAP2B,GAB2,PLCB2,RALA,LRP6,CTNNA1,HRAS,NCSTN,HIF1A,FAS,SHC1,CAMK2D,NLK,RHOG,CCND3,RHOD,TGFB2,PRKCE,ARHGEF2,GSK3B,GNA13,WNT5B,ADCY2,GNA12,DVL1,CDK6,RAPGEF3,FOS,BCL2L1,PLCB4,CCND2,RABIF,CDC42,ADCY1,PRKACA,MAPK10,CYCS,MAP2K3,BMP6	
Aspartate Degradation II	9.15E-01	NaN	2.86E-01	GOT1,MDH2	
Inositol Pyrophosphates Biosynthesis	9.15E-01	NaN	2.86E-01	IP6K3,PPIP5K2	
Superpathway of Serine and Glycine Biosynthesis I	9.15E-01	NaN	2.86E-01	PSAT1,SHMT2	
Isoleucine Degradation I	9.19E-01	NaN	2.14E-01	BCAT1,HADHB,ACAD8	
Phenylalanine Degradation IV (Mammalian, via Side Chain)	9.19E-01	NaN	2.14E-01	ALDH3A2,GOT1,SLC27A3	
CREB Signaling in Neurons	9.21E-01	1.7320508075688774	1.17E-01	PLCB2,ADCY2,GNA12,GNG2,RACK1,HRAS,POLR2K,GNB1,SHC1,CALM1 (includes others),PLCB4,CAMK2D,PLCE1,ADCY1,PRKACA,PRKCE,ATF4,GNA13,GNG5,GNG12	
Chondroitin Sulfate Biosynthesis	9.28E-01	NaN	1.43E-01	CHST2,HS6ST1,B3GALT6,UST,XYLT1,HS2ST1,CHST11,B3GAT3	
PPAR Signaling	9.29E-01	-1.507556722888818	1.29E-01	NR2F1,FOS,SHC1,SRA1,HSP90AB1,TNFRSF1A,IL1RN,PDGFA,HRAS,NR1H3,MAP4K4,SCAND1	
Hypoxia Signaling in the Cardiovascular System	9.31E-01	NaN	1.38E-01	UBE2D2,HSP90AB1,UBE2A,NQO1,ATF4,HIF1A,UBE2E1,UBE2I,UBE2F	
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	9.37E-01	1.091089451179962	1.17E-01	APOE,APOB,TNFRSF1A,PPP1R3C,MAP3K1,PPP1R11,PPP1R14B,FOS,PPP2R1A,LYZ,RHOG,RHOD,HOXA10,APOC1,CYBB,MAPK10,PRKCE,SERPINA1,IRF8,PPP2R1B,SIRPA	
Noradrenaline and Adrenaline Degradation	9.41E-01	NaN	1.58E-01	ALDH1B1,ALDH4A1,DHRS9,COMT,ALDH3A2,ALDH1A2	
Putrescine Degradation III	9.64E-01	NaN	1.90E-01	ALDH1B1,ALDH4A1,ALDH3A2,ALDH1A2	
Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I	9.64E-01	NaN	1.90E-01	NME1,AK1,RRM2B,NME2	
Cholecystokinin/Gastrin-mediated Signaling	9.65E-01	2.4961508830135313	1.29E-01	PLCB2,GNA12,HRAS,SHC1,FOS,PLCB4,RHOG,RHOD,IL1RN,MAPK10,PRKCE,MAP2K3,GNA13	
Glutathione-mediated Detoxification	9.67E-01	NaN	1.72E-01	GSTM5,GSTM3,GSTM4,HPGDS,GSTP1	
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency	9.68E-01	NaN	1.52E-01	NR2F1,NR6A1,SPP1,PHB,NR5A2,SH3GLB1,NR2F6	
AMPK Signaling	9.74E-01	-1.2909944487358056	1.18E-01	PFKFB3,LEP,PFKFB1,ACTB,ADIPOQ,CFTR,PFKL,MLST8,SMARCA4,PPP2R1A,AK1,GYS1,PCK2,ADRA2A,PRKACA,ATF4,MAP2K3,PPP2R1B,HLTF,PPAT,ADRA1A	
Cellular Effects of Sildenafil (Viagra)	9.8E-01	NaN	1.24E-01	SLC4A5,PLCB2,ADCY2,ACTB,MYL9,CALM1 (includes others),PLCB4,PLCE1,PABPC4,ADCY1,PRKACA,CACNG8,ACTG1,MYL12B,MYL12A,MYH1	
Synaptic Long Term Potentiation	9.89E-01	0.7745966692414834	1.26E-01	PLCB2,PPP1R3C,HRAS,RAPGEF3,PPP1R11,PPP1R14B,GRINA,CALM1 (includes others),PLCB4,CAMK2D,PLCE1,ADCY1,PRKACA,PRKCE,ATF4	
Bile Acid Biosynthesis, Neutral Pathway	9.96E-01	NaN	2.31E-01	AKR1C1/AKR1C2,CYP27A1,AKR1C3	
Fatty Acid Activation	9.96E-01	NaN	2.31E-01	ACSL3,SLC27A3,SLC27A4	
Glycogen Degradation III	9.96E-01	NaN	2.31E-01	GAA,TYMP,PYGB	
CD28 Signaling in T Helper Cells	1.01E00	2.886751345948129	1.27E-01	ARPC1B,ARPC5L,CD4,ARPC5,MAP3K1,PTPRC,CD28,CALM1 (includes others),CD3G,FOS,ACTR3,CDC42,FCER1G,MAPK10,ARPC4	
Dopamine Degradation	1.02E00	NaN	1.79E-01	ALDH1B1,ALDH4A1,COMT,ALDH3A2,ALDH1A2	
Superpathway of Cholesterol Biosynthesis	1.02E00	NaN	1.79E-01	MVD,PMVK,HADHB,MSMO1,HMGCS1	
Fatty Acid α-oxidation	1.03E00	NaN	2.00E-01	ALDH1B1,ALDH4A1,ALDH3A2,ALDH1A2	
Ceramide Signaling	1.03E00	2.1213203435596424	1.38E-01	FOS,CTSD,PPP2R1A,TNFRSF1A,MAP3K1,HRAS,CYCS,NSMAF,SMPD2,SMPD3,PPP2R1B	
Thioredoxin Pathway	1.04E00	NaN	3.33E-01	TXN,TXNRD1	
D-myo-inositol-5-phosphate Metabolism	1.05E00	NaN	1.24E-01	SOCS3,PLCB2,PTPN23,PPP1R1B,PPFIBP2,PPTC7,FIG4,PPP1R14B,PTPRC,PLCB4,PLCE1,DUSP1,PPP1R16B,PDXP,DUSP10,MTMR2,ALPL,SIRPA	
Acyl Carrier Protein Metabolism	1.05E00	NaN	1.00E00	AASDHPPT,	
Asparagine Biosynthesis I	1.05E00	NaN	1.00E00	ASNS,	
Glutamine Biosynthesis I	1.05E00	NaN	1.00E00	GLUL,	
Thio-molybdenum Cofactor Biosynthesis	1.05E00	NaN	1.00E00	MOCOS,	
Reelin Signaling in Neurons	1.06E00	NaN	1.39E-01	PAFAH1B2,APOE,ITGB2,CNR1,MAPT,MAPK8IP2,MAPK10,ARHGEF2,LRP8,GSK3B,APP	
IGF-1 Signaling	1.07E00	1.6329931618554523	1.34E-01	IGFBP6,FOS,IGFBP4,SOCS3,SHC1,CTGF,YWHAG,YWHAB,PRKACA,IGFBP3,HRAS,CSNK2B,CYR61	
Ethanol Degradation II	1.08E00	NaN	1.71E-01	ALDH1B1,ALDH4A1,ACSS3,DHRS9,ALDH3A2,ALDH1A2	
Acyl-CoA Hydrolysis	1.08E00	NaN	2.50E-01	PPT1,ACOT1,ACOT4	
Dopamine Receptor Signaling	1.09E00	-1.1338934190276817	1.41E-01	PPP2R1A,ADCY2,PPP1R1B,PPP1R3C,COMT,ADCY1,PRKACA,PPP1R11,PCBD1,PPP1R14B,PPP2R1B	
VDR/RXR Activation	1.09E00	1.0	1.41E-01	IGFBP6,SPP1,PDGFA,HOXA10,TGFB2,IGFBP3,CD14,PRKCE,CEBPB,SEMA3B,KLF4	
Thrombin Signaling	1.12E00	2.3570226039551585	1.21E-01	PLCB2,ADCY2,F2RL3,GNA12,GNG2,RACK1,HRAS,GNB1,MYL9,SHC1,PLCB4,CAMK2D,PLCE1,RHOG,RHOD,ADCY1,PRKCE,ARHGEF2,GNA13,GNG5,MYL12B,GNG12,MYL12A	
Role of NFAT in Cardiac Hypertrophy	1.15E00	2.23606797749979	1.23E-01	PLCB2,ADCY2,HDAC2,GNG2,RACK1,MAP3K1,HRAS,GNB1,SHC1,CALM1 (includes others),PLCB4,CAMK2D,PLCE1,ADCY1,TGFB2,PRKACA,MAPK10,PRKCE,MAP2K3,GSK3B,GNG5,GNG12	
LXR/RXR Activation	1.17E00	-1.386750490563073	1.32E-01	SCD,APOE,APOB,MSR1,TNFRSF1A,NR1H3,SAA2,LYZ,SREBF1,IL1RN,SAA1,APOC1,CD14,SERPINA1,PLTP,MMP9	
Circadian Rhythm Signaling	1.18E00	NaN	1.82E-01	NR1D1,ADCYAP1R1,BHLHE41,ATF4,ADCYAP1,GRINA	
Folate Polyglutamylation	1.19E00	NaN	4.00E-01	MTHFD1L,SHMT2	
Lysine Degradation II	1.19E00	NaN	4.00E-01	AASDHPPT,AASS	
Androgen Signaling	1.19E00	1.3416407864998738	1.35E-01	CALR,GNA12,GNG2,RACK1,POLR2K,MNAT1,GNB1,SHC1,CALM1 (includes others),HSPA4,PRKACA,PRKCE,GNA13,GNG5,GNG12	
P2Y Purigenic Receptor Signaling Pathway	1.22E00	1.0690449676496976	1.34E-01	PLCB2,ADCY2,RACK1,GNG2,HRAS,GNB1,FOS,PLCB4,PLCE1,ADCY1,PRKACA,PRKCE,P2RY12,ATF4,GNG5,GNG12	
Histamine Degradation	1.24E00	NaN	2.35E-01	ALDH1B1,ALDH4A1,ALDH3A2,ALDH1A2	
Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)	1.24E00	NaN	2.35E-01	MVD,PMVK,HADHB,HMGCS1	
Wnt/Ca+ pathway	1.25E00	1.1338934190276817	1.61E-01	PLCB4,PLCB2,PLCE1,DVL1,ATF4,DVL3,GSK3B,ROR1,WNT5B	
CDK5 Signaling	1.28E00	-0.5345224838248488	1.41E-01	ADCY2,PPP1R1B,PPP1R3C,EGR1,HRAS,PPP1R11,PPP1R14B,FOSB,PPP2R1A,MAPT,ADCY1,PRKACA,MAPK10,PPP2R1B	
FXR/RXR Activation	1.28E00	NaN	1.35E-01	APOE,APOB,SLC4A2,CYP27A1,NR1H3,SAA2,G6PC3,PCK2,SREBF1,IL1RN,SAA1,APOC1,MAPK10,NR5A2,ABCB11,SERPINA1,PLTP	
Glycine Betaine Degradation	1.29E00	NaN	3.00E-01	SRR,BHMT2,SHMT2	
Virus Entry via Endocytic Pathways	1.31E00	NaN	1.46E-01	HLA-A,ACTB,CLTC,HRAS,AP1B1,AP2S1,ITGB2,CDC42,FLNA,FLNC,PRKCE,TFRC,ACTG1	
PCP pathway	1.31E00	1.889822365046136	1.59E-01	PFN1,EFNB1,VANGL1,DVL1,MAPK10,DVL3,SDC4,SDC3,JUNB,WNT5B	
TCA Cycle II (Eukaryotic)	1.33E00	NaN	2.17E-01	ACO2,SDHC,OGDH,MDH2,FH	
Methylglyoxal Degradation III	1.33E00	NaN	2.50E-01	AKR7A2,AKR1C1/AKR1C2,AKR1C3,AKR1B1	
RAN Signaling	1.33E00	NaN	2.50E-01	CSE1L,TNPO1,RAN,KPNA1	
Complement System	1.39E00	1.0	1.89E-01	ITGB2,C1QA,C1QC,C1QB,C6,C1QBP,C3AR1	
Polyamine Regulation in Colon Cancer	1.4E00	NaN	2.27E-01	PSME1,PSMF1,OAZ1,PSME3,ODC1	
Stearate Biosynthesis I (Animals)	1.45E00	NaN	1.94E-01	ACSL3,PPT1,ACOT1,ACOT4,ELOVL1,SLC27A3,SLC27A4	
Gαi Signaling	1.46E00	-2.32379000772445	1.42E-01	ADCY2,RALA,NPY1R,CNR1,RACK1,GNG2,HRAS,GABBR1,GNB1,SHC1,LPAR1,ADRA2A,ADCY1,PRKACA,P2RY12,GNG5,GNG12	
Protein Kinase A Signaling	1.47E00	-0.31622776601683794	1.17E-01	PLCB2,PTPN23,PPP1R3C,DUSP6,RACK1,PPP1R14B,GNB1,PTPRC,CAMK2D,DUSP3,PLCE1,GYS1,FLNA,DUSP10,TGFB2,ATF4,PRKCE,PGP,GSK3B,GNA13,GNG5,ANAPC11,MYL12B,GNG12,MYL12A,ADCY2,PTPRK,YWHAG,YWHAB,PPP1R1B,GNG2,MAP3K1,PPP1R11,PYGB,MYL9,CALM1 (includes others),PLCB4,HIST1H1E,FLNC,DUSP1,ADCY1,PRKACA,DUSP4,H1F0,SIRPA	
Endoplasmic Reticulum Stress Pathway	1.48E00	NaN	2.38E-01	CALR,DDIT3,ATF4,HSPA5,EIF2S1	
Coagulation System	1.51E00	0.3779644730092272	2.00E-01	F8,F5,F13A1,SERPINA1,PLAU,TFPI,PLAT	
Superoxide Radicals Degradation	1.56E00	NaN	3.75E-01	NQO1,CYGB,SOD1	
Mechanisms of Viral Exit from Host Cells	1.6E00	NaN	1.95E-01	SH3GL1,VPS28,CHMP2A,ACTB,PRKCE,SH3GLB1,ACTG1,VPS4A	
Atherosclerosis Signaling	1.61E00	NaN	1.45E-01	APOE,VCAM1,APOB,MSR1,PDGFA,CMA1,CXCL12,TPSAB1/TPSB2,TNFRSF12A,ITGB2,COL5A3,LYZ,IL1RN,CSF1,APOC1,RARRES3,SERPINA1,MMP9	
Sertoli Cell-Sertoli Cell Junction Signaling	1.61E00	NaN	1.35E-01	TUBA1B,TNFRSF1A,TUBB4B,ACTB,TUBG1,TUBB2A,MAP3K1,CTNNA1,HRAS,TUBB,CLDN5,CDC42,SORBS1,KEAP1,PRKACA,MAPK10,SPTB,CLDN2,MTMR2,TUBA1C,MAP2K3,GSK3B,ACTG1,ACTN1	
Crosstalk between Dendritic Cells and Natural Killer Cells	1.62E00	NaN	1.57E-01	CD209,HLA-A,KLRD1,TYROBP,ACTB,CD83,FAS,HLA-G,CD28,TLN2,CAMK2D,TREM2,FSCN1,ACTG1	
Actin Nucleation by ARP-WASP Complex	1.63E00	3.162277660168379	1.79E-01	RHOG,ACTR3,ARPC1B,CDC42,RHOD,ARPC5L,GNA12,ARPC5,HRAS,ARPC4	
Lipid Antigen Presentation by CD1	1.63E00	NaN	2.31E-01	CALR,ARF6,FCER1G,PSAP,AP1B1,AP2S1	
Cardiac Hypertrophy Signaling	1.64E00	2.6	1.30E-01	PLCB2,RACK1,HRAS,GNB1,RHOG,PLCE1,RHOD,TGFB2,GSK3B,GNA13,GNG5,MAPKAPK2,MYL12B,GNG12,MYL12A,ADCY2,GNA12,MAP3K1,GNG2,EIF2B3,MYL9,CALM1 (includes others),PLCB4,ADRA2A,ADCY1,MAPK10,PRKACA,MAP2K3,ADRA1A	
Mevalonate Pathway I	1.64E00	NaN	3.08E-01	MVD,PMVK,HADHB,HMGCS1	
Glutathione Biosynthesis	1.66E00	NaN	6.67E-01	GCLM,GSS	
Inosine-5'-phosphate Biosynthesis II	1.66E00	NaN	6.67E-01	PAICS,ATIC	
NADH Repair	1.66E00	NaN	6.67E-01	NAXE,GAPDH	
Thyroid Hormone Biosynthesis	1.66E00	NaN	6.67E-01	CTSD,TPO	
G Beta Gamma Signaling	1.66E00	2.4961508830135313	1.59E-01	GNB1,SHC1,ADCY2,CDC42,GNA12,ADCY1,GNG2,RACK1,PRKACA,HRAS,PRKCE,GNA13,GNG5,GNG12	
Oxidative Ethanol Degradation III	1.66E00	NaN	2.63E-01	ALDH1B1,ALDH4A1,ACSS3,ALDH3A2,ALDH1A2	
Hepatic Fibrosis / Hepatic Stellate Cell Activation	1.72E00	NaN	1.37E-01	IGFBP4,LEP,CTGF,PDGFA,COL8A1,COL15A1,FAS,COL16A1,COL6A1,TGFB2,COL27A1,MYH1,COL5A2,VCAM1,EDNRB,TNFRSF1A,FGFR2,FGF1,MYL9,COL5A3,CSF1,IGFBP3,IL10RA,CD14,MMP9	
Glycoaminoglycan-protein Linkage Region Biosynthesis	1.74E00	NaN	4.29E-01	B3GALT6,XYLT1,B3GAT3	
Glucocorticoid Receptor Signaling	1.74E00	NaN	1.27E-01	HRAS,TAF10,MNAT1,HSPA5,TAF13,SMARCA4,SHC1,HSPA4,HSP90AB1,PCK2,ANXA1,TGFB2,FKBP5,SRA1,VCAM1,TAF6,ACTB,HSPA9,MAP3K1,POLR2K,CEBPB,PCK1,HSPA2,HSPA8,FOS,BCL2L1,CD3G,DUSP1,IL1RN,PRKACA,FKBP4,MAPK10,PLAU,HLTF,UBE2I	
Phospholipase C Signaling	1.75E00	3.1304951684997055	1.31E-01	PEBP1,PLCB2,RALA,RACK1,HRAS,GNB1,HMOX1,SHC1,RHOG,PLCE1,RHOD,PRKCE,ATF4,ARHGEF2,GNA13,GNG5,MYL12B,GNG12,MYL12A,ADCY2,PLD3,HDAC2,FCGR2A,GNG2,RAPGEF3,MYL9,CALM1 (includes others),CD3G,PLCB4,ADCY1,FCER1G	
Estrogen Receptor Signaling	1.76E00	NaN	1.48E-01	SRA1,TAF6,MED20,PHB2,HRAS,POLR2K,PCK1,TAF10,MNAT1,TAF13,SMARCA4,G6PC3,CTBP1,SHC1,PCK2,MED15,MED16,ESR2,CARM1	
RAR Activation	1.77E00	NaN	1.37E-01	AKR1C3,RPL7A,MNAT1,SMARCA4,NR2F1,TGFB2,PRKCE,CSNK2B,NR2F6,MAPKAPK2,ZBTB16,ADCY2,SRA1,ACTB,MAP3K1,FOS,DHRS9,DUSP1,ALDH1A2,ADCY1,MAPK10,IGFBP3,PRKACA,HLTF,SCAND1,CARM1	
TR/RXR Activation	1.78E00	NaN	1.65E-01	AKR1C1/AKR1C2,UCP2,AKR1C3,GPS2,THRA,ME1,HIF1A,PCK1,THRSP,ENO1,TBL1Y,SREBF2,SREBF1,SYT2	
14-3-3-mediated Signaling	1.84E00	0.9045340337332909	1.54E-01	TUBA1B,PLCB2,YWHAG,TUBB4B,YWHAB,TNFRSF1A,TUBG1,TUBB2A,HRAS,TUBB,FOS,PLCB4,PLCE1,MAPT,MAPK10,PRKCE,TUBA1C,GSK3B	
Germ Cell-Sertoli Cell Junction Signaling	1.86E00	NaN	1.44E-01	TUBA1B,CFL1,TNFRSF1A,TUBB4B,ACTB,TUBG1,TUBB2A,MAP3K1,CTNNA1,HRAS,TUBB,RHOG,CDC42,SORBS1,RHOD,KEAP1,TGFB2,MAPK10,MTMR2,TUBA1C,MAP2K3,ACTG1,ACTN1	
Regulation of Actin-based Motility by Rho	1.88E00	3.7416573867739413	1.65E-01	PFN1,ARPC1B,CFL1,ARPC5L,ACTB,ARPC5,MYL9,ACTR3,RHOG,CDC42,RHOD,ARHGDIA,MYL12B,ARPC4,MYL12A	
Ethanol Degradation IV	1.89E00	NaN	2.61E-01	ALDH1B1,ALDH4A1,ACSS3,ALDH3A2,ALDH1A2,CYGB	
Purine Nucleotides De Novo Biosynthesis II	1.92E00	NaN	3.64E-01	IMPDH2,PAICS,ATIC,PPAT	
Huntington's Disease Signaling	1.95E00	-0.3779644730092272	1.35E-01	PLCB2,RACK1,HRAS,HSPA5,GNB1,SHC1,CTSD,HSPA4,PRKCE,ATF4,GNG5,GNG12,CAPN6,HDAC2,PSMF1,HSPA9,CLTC,GNG2,POLR2K,HSPA2,RPH3A,GPAA1,PSME3,HSPA8,BCL2L1,PLCB4,PSME1,CAPNS1,DNAJC5,CYCS,CAPN2	
Glycogen Biosynthesis II (from UDP-D-Glucose)	1.95E00	NaN	5.00E-01	GYS1,GBE1,GYG2	
Pentose Phosphate Pathway (Non-oxidative Branch)	1.95E00	NaN	5.00E-01	RPE,TKT,TALDO1	
Selenocysteine Biosynthesis II (Archaea and Eukaryotes)	1.95E00	NaN	5.00E-01	SEPHS2,SEPHS1,SARS	
α-Adrenergic Signaling	2.05E00	1.0	1.72E-01	ADCY2,RACK1,GNG2,HRAS,PYGB,GNB1,CALM1 (includes others),GYS1,ADRA2A,ADCY1,PRKACA,PRKCE,GNG5,ADRA1A,GNG12	
Actin Cytoskeleton Signaling	2.05E00	3.922322702763681	1.39E-01	PFN1,ARPC1B,PDGFA,ARPC5,HRAS,SLC9A1,SHC1,ACTR3,FLNA,GNA13,TMSB10/TMSB4X,TMSB4Y,MYL12B,GNG12,ACTN1,MYL12A,MYH1,CFL1,ARPC5L,ACTB,GNA12,FGF1,MYL9,TLN2,CDC42,CD14,ARHGAP35,NCKAP1L,ACTG1,ARPC4	
Caveolar-mediated Endocytosis Signaling	2.06E00	NaN	1.83E-01	ITGB2,RAB5C,FLNC,HLA-A,FLNA,ACTB,ITGA8,COPE,ITGAV,FLOT1,COPB1,ACTG1,COPG1	
Pentose Phosphate Pathway	2.08E00	NaN	4.00E-01	PGD,RPE,TKT,TALDO1	
SAPK/JNK Signaling	2.1E00	2.840187787218772	1.70E-01	GNA12,MAPK8IP2,MAP3K1,GNG2,HRAS,HNRNPK,GNB1,SHC1,CDC42,DUSP10,FCER1G,MAPK10,DUSP4,GNA13,GNG5,MAP4K4	
4-hydroxyproline Degradation I	2.11E00	NaN	1.00E00	ALDH4A1,HOGA1	
CCR5 Signaling in Macrophages	2.16E00	NaN	1.88E-01	GNB1,FOS,CD3G,CALM1 (includes others),CD4,GNG2,RACK1,FCER1G,MAPK10,PRKCE,GNG5,FAS,GNG12	
ILK Signaling	2.18E00	1.876629726513673	1.46E-01	HIF1A,PPP1R14B,RHOG,RHOD,FLNA,ATF4,GSK3B,TMSB10/TMSB4X,TMSB4Y,TESK1,ACTN1,DSP,MYH1,CFL1,TNFRSF1A,ACTB,MYL9,ITGB2,FOS,PPP2R1A,CDC42,LIMS1,FLNC,MAPK10,ACTG1,PPP2R1B,MMP9	
fMLP Signaling in Neutrophils	2.2E00	3.3565855667130946	1.67E-01	FPR3,PLCB2,ARPC1B,ARPC5L,GNG2,ARPC5,RACK1,HRAS,GNB1,CALM1 (includes others),PLCB4,ACTR3,CDC42,CYBB,PRKCE,GNG5,ARPC4,GNG12	
Tetrapyrrole Biosynthesis II	2.22E00	NaN	6.00E-01	UROS,ALAS1,HMBS	
Xenobiotic Metabolism Signaling	2.22E00	NaN	1.36E-01	ALDH4A1,GSTM5,NQO2,MAF,HS2ST1,HRAS,CES2,CHST2,HMOX1,HS6ST1,CES1,CAMK2D,HSP90AB1,UST,KEAP1,ALDH3A2,GSTM4,CHST11,PRKCE,FMO1,NFE2L2,ALDH1B1,SRA1,GSTM3,NQO1,MAP3K1,CYP1B1,FTL,PPP2R1A,ALDH1L2,RBX1,ALDH1A2,MAP2K3,ABCC3,PPP2R1B,SCAND1,GSTP1	
IL-1 Signaling	2.24E00	1.507556722888818	1.76E-01	ADCY2,TOLLIP,GNA12,RACK1,MAP3K1,GNG2,IRAK1,GNB1,FOS,ADCY1,PRKACA,MAPK10,MAP2K3,GNA13,GNG5,GNG12	
G Protein Signaling Mediated by Tubby	2.25E00	NaN	2.50E-01	GNB1,PLCB4,PLCB2,GNG2,RACK1,TUB,GNG5,GNG12	
Ephrin Receptor Signaling	2.25E00	3.3565855667130946	1.49E-01	ARPC1B,PDGFA,RACK1,ARPC5,CXCL12,HRAS,GRINA,GNB1,SHC1,ACTR3,SORBS1,EFNB1,ATF4,GNA13,GNG5,GNG12,CFL1,ARPC5L,GNA12,GNG2,FGF1,SDCBP,CDC42,EPHB3,MAP4K4,ARPC4	
Heme Biosynthesis II	2.27E00	NaN	4.44E-01	UROS,FECH,ALAS1,HMBS	
Integrin Signaling	2.31E00	4.270992778072193	1.45E-01	RAP2B,PFN1,RALA,ARPC1B,ARF1,ARPC5,ITGA8,HRAS,SHC1,ARF6,ACTR3,RHOG,RHOD,ITGAV,GSK3B,MYL12B,ACTN1,MYL12A,CAPN6,ARPC5L,ACTB,MYL9,ITGB2,TLN2,CAPNS1,CDC42,LIMS1,CAPN2,ACTG1,ARPC4	
Glycolysis I	2.32E00	NaN	2.80E-01	ENO1,PGAM1,PKM,GAPDH,ALDOA,PFKL,ALDOC	
Ephrin B Signaling	2.36E00	1.6329931618554523	1.92E-01	GNB1,CFL1,CDC42,EFNB1,GNA12,GNG2,RACK1,CXCL12,EPHB3,HRAS,GNA13,GNG5,HNRNPK,GNG12	
Amyloid Processing	2.36E00	2.23606797749979	2.16E-01	CAPN6,CAPNS1,MAPT,PRKACA,MARK1,NCSTN,PRKCE,CAPN2,GSK3B,CSNK2B,APP	
CXCR4 Signaling	2.42E00	2.9824045403173027	1.58E-01	PLCB2,ADCY2,EGR1,CD4,GNA12,GNG2,RACK1,CXCL12,HRAS,GNB1,MYL9,FOS,PLCB4,RHOG,RHOD,ADCY1,MAPK10,PRKCE,GNA13,GNG5,ELMO2,MYL12B,GNG12,MYL12A	
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes	2.52E00	4.123105625617661	1.83E-01	GAB2,PLD3,ARPC1B,ARPC5L,FCGR2A,ACTB,ARPC5,FYB,MYO5A,HMOX1,ARF6,TLN2,ACTR3,CDC42,PRKCE,ACTG1,ARPC4	
Aldosterone Signaling in Epithelial Cells	2.75E00	1.1338934190276817	1.64E-01	ICMT,PLCB2,HSPH1,HSPA9,HSPB8,DNAJC1,HSPD1,DNAJC15,HSPA5,SLC9A1,HSPA2,HSPA8,HSPA4,PLCB4,DNAJC5,PLCE1,HSP90AB1,DNAJC4,DUSP1,HSPE1,DNAJC18,HSPA13,PRKCE,HSPB6,AHCY	
Signaling by Rho Family GTPases	2.84E00	3.530090432487313	1.50E-01	CDH18,SEPT9,ARPC1B,SEPT3,RACK1,ARPC5,SLC9A1,CLIP1,CDH11,GNB1,RHOG,ACTR3,RHOD,CYBB,ARHGEF2,CDC42EP1,GNA13,GNG5,MYL12B,GNG12,MYL12A,CFL1,ARPC5L,ACTB,GNA12,GNG2,DES,PKN1,MYL9,FOS,CDC42,CDH20,MAPK10,ACTG1,ARPC4	
Breast Cancer Regulation by Stathmin1	2.85E00	NaN	1.57E-01	TUBA1B,PLCB2,PPP1R3C,RACK1,HRAS,TUBB,PPP1R14B,GNB1,SHC1,CAMK2D,PRKCE,TUBA1C,ARHGEF2,GNA13,GNG5,GNG12,ADCY2,TUBB4B,TUBG1,GNG2,TUBB2A,PPP1R11,CALM1 (includes others),PLCB4,PPP2R1A,CDC42,ADCY1,PRKACA,UHMK1,PPP2R1B	
RhoGDI Signaling	2.9E00	-2.400396792595916	1.62E-01	ARPC1B,CDH18,RACK1,ARPC5,CDH11,GNB1,RHOG,ACTR3,RHOD,ARHGEF2,GNA13,GNG5,MYL12B,GNG12,MYL12A,CFL1,ARPC5L,GNA12,ACTB,GNG2,MYL9,CDC42,CDH20,ARHGAP35,ARHGDIA,ESR2,ACTG1,ARPC4	
Aryl Hydrocarbon Receptor Signaling	2.91E00	1.3416407864998738	1.71E-01	ALDH4A1,ALDH1B1,GSTM5,GSTM3,NQO2,NQO1,CDK6,SMARCA4,CYP1B1,FAS,NR2F1,FOS,CTSD,CCND2,HSP90AB1,CCND3,ALDH1L2,ALDH3A2,ALDH1A2,TGFB2,GSTM4,NFE2L2,ESR2,GSTP1	
Gluconeogenesis I	3E00	NaN	3.20E-01	ENO1,PGAM1,GAPDH,ALDOA,ME2,ME1,MDH2,ALDOC	
Epithelial Adherens Junction Signaling	3E00	NaN	1.71E-01	TUBA1B,ARPC1B,ARPC5,CTNNA1,HRAS,TUBB,CLIP1,ACTR3,SORBS1,KEAP1,TGFB2,TUBA1C,ACVR1C,ACTN1,MYH1,TUBB4B,ARPC5L,ACTB,TUBG1,TUBB2A,FGF1,MYL9,CDC42,ACTG1,ARPC4	
RhoA Signaling	3.01E00	4.024922359499621	1.80E-01	PLXNA1,PFN1,CFL1,SEPT9,ARPC1B,ANLN,SEPT3,ARPC5L,ACTB,GNA12,ARPC5,PKN1,MYL9,ACTR3,LPAR1,ARHGAP35,CDC42EP1,GNA13,ACTG1,MYL12B,ARPC4,MYL12A	
Dolichyl-diphosphooligosaccharide Biosynthesis	3.03E00	NaN	5.00E-01	ALG3,DPM1,DPM2,ALG8,DPM3	
Cysteine Biosynthesis III (mammalia)	3.09E00	NaN	3.68E-01	AHCYL1,PRMT3,PRMT5,MAT2A,AHCYL2,MRM2,AHCY	
LPS/IL-1 Mediated Inhibition of RXR Function	3.29E00	0.5773502691896258	1.58E-01	APOE,ALDH4A1,GSTM5,HS2ST1,ALAS1,CES2,SLC27A4,IRAK1,CHST2,HS6ST1,UST,ALDH3A2,GSTM4,ABCB11,CHST11,FMO1,HMGCS1,ALDH1B1,ACSL3,TNFRSF1A,GSTM3,MAP3K1,NR1H3,ALDH1L2,IL1RN,SREBF1,ALDH1A2,APOC1,NR5A2,CD14,SLC27A3,PLTP,ABCC3,CYP4A11,GSTP1	
Clathrin-mediated Endocytosis Signaling	3.41E00	NaN	1.68E-01	APOE,RAB4A,APOB,RAB5C,ARPC1B,PDGFA,ARPC5,SH3GLB1,AP1B1,LYZ,ARF6,ACTR3,AAK1,DAB2,SERPINA1,STAM,CSNK2B,ARPC5L,ACTB,CLTC,RAB7A,AP2S1,FGF1,HSPA8,SH3GL1,ITGB2,CDC42,APOC1,TFRC,ACTG1,ARPC4	
Methionine Degradation I (to Homocysteine)	3.44E00	NaN	4.12E-01	AHCYL1,PRMT3,PRMT5,MAT2A,AHCYL2,MRM2,AHCY	
IL-8 Signaling	3.45E00	4.913538149119954	1.68E-01	PLCB2,RACK1,HRAS,IRAK1,RAB11FIP2,GNB1,HMOX1,RHOG,CCND3,RHOD,ITGAV,CYBB,PRKCE,GNA13,GNG5,MYL12B,GNG12,LASP1,VCAM1,PLD3,GNA12,GNG2,CSTB,MYL9,FOS,BCL2L1,ITGB2,CCND2,MAPK10,MAP4K4,MMP9	
Superpathway of Methionine Degradation	3.53E00	NaN	3.12E-01	AHCYL1,PRMT3,PRMT5,PCCB,GOT1,MAT2A,AHCYL2,BHMT2,MRM2,AHCY	
Axonal Guidance Signaling	3.95E00	NaN	1.43E-01	TUBA1B,ADAMTS8,PLCB2,PFN1,ARPC5,UNC5B,RACK1,CXCL12,HRAS,TUBB,GNB1,PLCE1,TUBA1C,GSK3B,GNA13,CHMP1A,ADAMTS5,WNT5B,GNG12,CFL1,TUBB2A,GNG2,MYL9,SDCBP,ADAM12,CDC42,PRKACA,RTN4,ERAP2,ADAM17,PLXNA3,ARPC1B,PDGFA,SHC1,ACTR3,RHOD,SRGAP1,EFNB1,PRKCE,PSMD14,SEMA3B,GNG5,SHANK2,MYL12B,MYL12A,SEMA3E,PLXNA1,ARPC5L,TUBB4B,GNA12,TUBG1,PLXND1,PLCB4,KIF7,GLIS2,NTRK3,EPHB3,BMP6,ADAM9,SEMA4B,MMP9,ARPC4	
mTOR Signaling	4.39E00	2.1105794120443453	1.82E-01	RPS3A,FKBP1A,HRAS,HIF1A,RPS11,HMOX1,RHOG,EIF4G2,RHOD,RPS13,PRKCE,RPS2,RPS12,RPS3,RPS5,RPS24,RPS19,PLD3,RPS8,RPS10,RPS21,RPS29,MLST8,FAU,EIF3G,RPS15,RPS4Y1,PPP2R1A,RPS16,EIF4A1,RPS27L,PPP2R1B,RPSA,EIF3K	
Regulation of eIF4 and p70S6K Signaling	5.45E00	0.0	2.12E-01	RPS3A,HRAS,EIF2S1,RPS11,SHC1,EIF4G2,RPS13,RPS2,RPS12,RPS5,RPS3,EIF1AY,RPS24,RPS19,RPS8,RPS10,EIF2B3,RPS21,RPS29,EIF2S2,FAU,EIF3G,RPS15,PPP2R1A,RPS4Y1,RPS16,RPS27L,EIF4A1,PPP2R1B,RPSA,EIF3K	
Unfolded protein response	5.65E00	NaN	3.15E-01	CALR,DDIT3,HSPH1,HSPA9,CEBPB,HSPA5,HSPA2,CEBPG,HSPA8,SEL1L,HSPA4,SREBF2,SREBF1,EDEM1,ATF4,NFE2L2,AMFR	
phagosome maturation	5.83E00	NaN	2.33E-01	TUBA1B,ATP6V0C,ATP6V0B,RAB5C,VPS28,PRDX1,HLA-A,PRDX5,DYNLT1,TUBB,ATP6AP1,DYNLL1,CYBB,TUBA1C,TPO,VPS11,CALR,TUBB4B,TUBG1,TUBB2A,RAB7A,ATP6V1A,GPAA1,ATP6V1E1,LAMP2,ATP6V1F,ATP6V0D1,ATP6V1B2	
Protein Ubiquitination Pathway	6.79E00	NaN	1.92E-01	UBE2A,USP5,DNAJC15,HSPA5,TCEB2,HSPA4,ANAPC11,PSMB5,HSPA9,PSMC4,PSMD3,HSPA8,PSMB7,UBE2D2,DNAJC5,RBX1,PSMA5,HSPA13,DNAJC18,PSMA4,UBE2E1,UBE2I,USP18,PSMD7,HLA-A,PSMB10,HSPB8,UBE2F,UCHL1,PSMD10,HSP90AB1,DNAJC4,STUB1,HSPE1,PSMD14,PSMA3,HSPB6,AMFR,MED20,HSPH1,DNAJC1,HSPD1,PSMB6,HSPA2,PSMD8,PSME1,USP22,PSMD2,USP9Y	
Remodeling of Epithelial Adherens Junctions	7.36E00	2.82842712474619	3.24E-01	TUBA1B,NME1,RALA,RAB5C,ARPC1B,ARPC5L,TUBB4B,ACTB,TUBG1,TUBB2A,ARPC5,RAB7A,CTNNA1,TUBB,CLIP1,ARF6,ACTR3,TUBA1C,ACTG1,MAPRE3,ACTN1,ARPC4	
tRNA Charging	8.06E00	NaN	4.36E-01	CARS,RARS2,GARS,TARS,MARS,EPRS,FARSB,FARSA,WARS2,NARS,WARS,YARS2,YARS,EARS2,AARS,SARS,IARS	
NRF2-mediated Oxidative Stress Response	1.23E01	3.8996021017180893	2.72E-01	MAF,HRAS,DNAJC15,ABCC1,KEAP1,ATF4,GSK3B,TXN,GCLM,GSTM3,JUNB,TXNRD1,ERP29,DNAJC5,STIP1,RBX1,DNAJC18,MAP2K3,SQSTM1,HACD3,ACTG1,GSTP1,EPHX1,FTH1,AKR7A2,GSTM5,PPIB,PRDX1,NQO2,DNAJA4,HSPB8,MAFG,HMOX1,DNAJC4,UBE2K,GSTM4,PRKCE,FMO1,FKBP5,NFE2L2,ACTB,NQO1,MAP3K1,DNAJC1,SOD1,FOS,FTL,CCT7,AOX1	
Oxidative Phosphorylation	1.74E01	NaN	3.94E-01	NDUFA4,ATP5G1,COX7B,ATP5H,ATP5D,UQCRH,COX8A,ATP5L,NDUFA1,NDUFA2,NDUFB9,MT-CYB,NDUFS6,ATP5J2,UQCRFS1,ATP5I,COX4I1,NDUFS4,NDUFA8,MT-CO1,MT-ATP6,NDUFB4,COX17,SURF1,NDUFV3,COX7A2L,UQCR11,SDHC,COX7A1,NDUFA13,MT-ND1,MT-ND5,NDUFS8,NDUFA11,UQCR10,NDUFA6,CYC1,NDUFB7,COX5A,NDUFA12,CYCS,UQCRC1,UQCRQ	
Mitochondrial Dysfunction	1.87E01	NaN	3.33E-01	ATP5D,ACO2,COX8A,ATP5L,NCSTN,NDUFA4L2,NDUFA1,VDAC2,NDUFS6,UQCRFS1,NDUFA8,SURF1,UQCR11,SDHC,COX7A1,TXN2,NDUFA6,NDUFB7,MAPK10,NDUFA12,VDAC1,NDUFA4,ATP5G1,COX7B,ATP5H,UQCRH,PRDX5,NDUFA2,NDUFB9,PARK7,MT-CYB,ATP5J2,OGDH,ATP5I,COX4I1,NDUFS4,MT-CO1,MT-ATP6,NDUFB4,COX17,UCP2,GLRX2,NDUFV3,COX7A2L,NDUFA13,APP,FIS1,MT-ND1,MT-ND5,NDUFS8,NDUFA11,UQCR10,CYC1,COX5A,CYCS,UQCRC1,UQCRQ	
EIF2 Signaling	1.98E01	5.578018081208209	3.32E-01	HRAS,RPS11,RPL13,EIF4G2,RPS13,EIF5,RPL21,RPL19,RPS2,GSK3B,RPL36,EIF2AK1,RPL32,RPS8,RPL29,EIF2B3,RPL12,RPL37A,RPL28,EIF2S2,RPL9,RPL8,RPL41,RPL13A,EIF3K,RPSA,RPL24,RPLP1,RPL36A,RPS3A,RPL26,RPL7A,EIF2S1,SHC1,RPL14,RPL35,RPL18A,UBA52,RPS12,RPS5,RPS3,RPL31,RPL18,RPS24,RPS19,RPL4,RPL17,RPL30,RPS10,RPS21,RPS29,FAU,EIF3G,RPS15,RPS4Y1,RPS16,RPS27L,EIF4A1,RPL37,RPLP0,RPL38	

Upstream Regulators for My Projects->David Bulger->P3
Analysis	ID	Upstream Regulator	Expr Fold Change	Molecule Type	Predicted Activation State	Activation z-score	Notes	Bias Term	Bias-corrected z-score	p-value of overlap	Target molecules in dataset	Mechanistic Network	
P3	 	RICTOR	1.104	other	Inhibited	-8.362	bias	-0.514	 	5.15E-39	ATP5D,ATP5G1,ATP5H,ATP5J2,ATP5L,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V0D1,ATP6V1A,ATP6V1B2,ATP6V1E1,ATP6V1F,BCL2L1,BSG,CD4,COX17,COX4I1,COX5A,COX7A1,COX7A2L,COX7B,COX8A,CYC1,FAU,HIF1A,NDUFA1,NDUFA11,NDUFA2,NDUFA4,NDUFA4L2,NDUFA6,NDUFA8,NDUFB4,NDUFB7,NDUFB9,NDUFC2,NDUFS4,NDUFS6,NDUFS8,NDUFV3,POMP,PRKCE,PSMA3,PSMA4,PSMA5,PSMB10,PSMB5,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD3,PSMD7,PSMD8,PSME1,PSME3,PSMF1,RPL12,RPL13A,RPL14,RPL17,RPL18,RPL21,RPL26,RPL28,RPL30,RPL38,RPL4,RPL41,RPL7A,RPL8,RPL9,RPLP0,RPS10,RPS11,RPS13,RPS15,RPS19,RPS2,RPS21,RPS24,RPS29,RPS3,RPS4Y1,RPS5,RPS8,RPSA,RSL24D1,SDHC,UQCR10,UQCR11,UQCRC1,UQCRFS1,UQCRQ,VCAM1	 	
P3	 	sirolimus	 	chemical drug	Inhibited	-6.909	bias	-0.423	-2.612	1.80E-30	ACTB,ANXA5,APP,ARF1,ASNS,ASS1,ATF4,ATP5G1,BCL2L1,CCND2,CCND3,CD151,CD209,CEBPB,CRAT,CSF1,CYCS,DAD1,DDIT3,DES,DVL3,EEF1A1,EGR1,EIF2S1,EIF4A1,EIF5,ENO1,FAS,FOS,FSCN1,FTH1,GSTP1,HIF1A,HMOX1,HSP90AB1,HSPA4,HSPA5,HSPD1,JUNB,KLF2,LEP,MAF,MAPT,MBP,MMP14,MMP9,NCAM1,NPM1,OAZ1,ODC1,PKM,PLIN1,PLIN2,PPIA,PRDX5,PRNP,PSMA3,PSMA4,PSMB6,PSMB7,PSMD8,PSME3,PYGB,RACK1,RAN,RPL13A,RPL18,RPL18A,RPL19,RPL21,RPL29,RPL30,RPL32,RPL35,RPL37,RPL37A,RPL38,RPL41,RPL7A,RPL8,RPLP0,RPN2,RPS10,RPS12,RPS13,RPS15,RPS16,RPS19,RPS2,RPS21,RPS24,RPS29,RPS3,RPS3A,RPS5,RPS8,RPSA,SCD,SLC1A5,SLC25A5,SLC38A3,SLC3A2,SNRPD2,SNRPF,SOCS3,SOD1,SQSTM1,SREBF1,TARS,TOP2A,TPM3,TUBB2A,UBA52,UCP2,VCAM1	CEBPA,ELK1,HIF1A,Insulin,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF,TP53,nitric oxide,sirolimus	
P3	 	beta-estradiol	 	chemical - endogenous mammalian	Activated	3.716	bias	0.260	-0.187	8.25E-28	AARS,ABCB11,ACTB,ADAMTS5,ADCY1,ADIPOQ,ADM2,AES,AIF1,ALCAM,ALDH1A2,ALDH4A1,ALDOA,ALK,ANO2,ANXA1,AP1B1,AP3D1,APOE,APP,ATF5,ATP5I,ATP6V1F,BCAT1,BCL2L1,BIN1,BSG,BTG2,CA12,CALM1 (includes others),CALR,CBX6,CCND2,CCND3,CCNI,CD14,CDC42,CDH11,CEBPB,CFTR,CHI3L1,CLCN3,CLSTN2,CNBP,CNP,CNR1,COMT,COX5A,CPM,CSE1L,CSTB,CTGF,CTPS1,CTSB,CTSD,CUBN,CXCL12,CYBB,CYP1B1,CYP4B1,CYR61,DCLK1,DDIT3,DERL1,DHRS9,DNAJC1,DPM2,DSP,DUSP1,DUSP10,DUSP3,DUSP4,DUSP6,DYNLL1,ECHDC2,EGR1,EIF2S1,EIF3G,EMG1,EMP1,ENO1,EPB41L3,ERBB4,ERH,ESR2,FADS3,FAM162A,FARSA,FARSB,FAS,FCGR2A,FGD6,FGFR2,FHL1,FLOT1,FMO1,FOS,FOSB,FST,GAB2,GARS,GCSH,GEM,GJB2,GM2A,GMFB,GNB1,GNL3,GPC1,GSK3B,GSTM3,GSTP1,HCST,HDAC2,HLA-A,HMGCS1,HMOX1,HNRNPK,HOXA10,HRAS,HSD11B2,HSP90AB1,HSPA2,HSPA4,HSPA5,HSPA8,HSPA9,HSPB8,HSPD1,HSPH1,IARS,ID4,IFI30,IFRD2,IGFBP3,IGFBP4,IGFBP6,IGSF6,IMPDH2,INPP4B,IP6K3,IPO4,ITGAV,ITGB2,JUNB,KCND3,KIT,KLF2,KLF4,LAGE3,LAPTM5,LDB3,LEP,LHFPL2,LIMA1,LITAF,LMCD1,LOC102724428/SIK1,LRP8,LTF,LYZ,MAL2,MAPT,MATN2,MBD4,MBP,MKI67,MLH1,MMP9,MMRN1,MPC1,MPEG1,MSMO1,MT-CO1,NARS,NCAM1,NFE2L2,NHP2,NME1,NPM1,NPY1R,NR1H3,NR2F1,NR4A1,NR5A2,NTRK3,NUCB2,NUPR1,ODC1,OGDH,PCBD1,PDAP1,PDGFA,PFKL,PHB2,PKM,PLAA,PLAT,PLAU,PLIN2,PNRC2,PPIB,PPP1R3C,PRMT5,PSAT1,PTGFR,PTP4A2,PTPRK,PTX3,QSOX1,RALA,RAN,RBBP8,RERG,RET,RMND1,RPL17,RPL21,RPN2,RPS11,RPS13,SAA1,SDC3,SDC4,SEMA3B,SERPINA1,SFRP1,SFRP2,SHC1,SIAH2,SLC20A1,SLC24A3,SLC39A6,SLC3A2,SLC7A2,SLC7A5,SLC9A1,SNCG,SOCS3,SOX9,SQSTM1,SREBF1,ST6GALNAC4,STC2,STIP1,STON1,STS,STXBP1,SYT11,TACR1,TARS,TESK1,TFPI,TGFB2,THBS1,THRA,THRSP,THSD4,TIMM13,TMEM2,TNFRSF1A,TOP2A,TP63,TPO,TRAF3,TSPO,TUBG1,TXN,TXN2,TXNL4A,TXNRD1,UBIAD1,VAPA,VCAM1,VPS11,WNT5B,YARS	CEBPA,ESR1,ESR2,IGF1,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TNF,TP53,beta-estradiol	
P3	 	CD 437	 	chemical drug	Inhibited	-7.136	bias	-0.592	 	4.57E-27	AKR1B1,ALDOA,AP2S1,ARF1,ARL2,ARSA,ATP5L,ATP6V0C,BANF1,CCT3,CEBPB,COX7A2L,COX7B,EIF3G,EIF4A1,EIF5A,ENO1,ERH,FAS,FKBP5,FOS,FSCN1,FTH1,FTL,GDF15,HSPA8,ILF2,LSM3,MTCH2,NARS,NDUFB9,NME1,NOP10,NPM1,NR4A1,ODC1,PFN1,PGAM1,PHYH,PSMA4,PSMD3,PSMF1,RBX1,RPL13,RPL13A,RPL19,RPL24,RPL36A,RPL8,RPLP1,RPS10,RPS15,RPS16,RPS2,SH3BGRL3,SLC25A5,SLC25A6,SNRPD2,SNRPF,SOD1,STOML2,TIMM8B,TMEM14C,TMSB10/TMSB4X,TUBA1B,TXN,UBA52,UBL5,UGCG,UQCRH,VDAC2	 	
P3	 	MYCN	-2.271	transcription regulator	Activated	5.351	 	0.147	4.103	3.12E-25	ABCC1,ACTB,ACTG1,ALDOA,ARPC1B,BCL2L1,CCND2,CDC42,CDH11,COL5A2,COL8A1,CTDNEP1,CTGF,DKK3,EEF1A1,EEF1G,EIF4A1,EIF4G2,EIF5A,FAU,FGFR2,GAPDH,HDAC2,HLA-A,HMGA1,HSP90AB1,HSPD1,MYL12A,NCAM1,NME1,NME2,NPM1,ODC1,PHB,PSMB6,PSMB7,RPL12,RPL13,RPL13A,RPL17,RPL18,RPL18A,RPL19,RPL21,RPL24,RPL26,RPL28,RPL29,RPL30,RPL31,RPL35,RPL37,RPL37A,RPL38,RPL4,RPL41,RPL8,RPL9,RPLP0,RPLP1,RPS12,RPS13,RPS15,RPS16,RPS19,RPS2,RPS24,RPS3,RPS3A,RPS5,RPS8,SOX17,TNFRSF1A,TUBA1B,TUBB,UCHL1	MYCN,RNA polymerase II,TP53	
P3	 	ST1926	 	chemical drug	Inhibited	-7.482	bias	-0.684	 	1.04E-24	ACTB,AKR1B1,AP2S1,ARF1,ARSA,ATP5I,CCT3,CEBPB,CFL1,CHCHD2,COX7A2L,COX7B,DYNLL1,EIF3G,EIF4A1,EIF4G2,EIF5A,ENO1,FKBP5,H2AFZ,ILF2,LSM3,MTCH2,NARS,NDUFB9,NME1,NOP10,NPM1,ODC1,PFN1,PSMA4,PSMD3,PSMF1,RBX1,RPL13,RPL18A,RPL19,RPL24,RPL29,RPL32,RPL36A,RPL41,RPL8,RPLP1,RPS10,RPS15,RPS2,SLC25A6,SNRPD2,SNRPF,SOD1,TIMM8B,TMEM14C,TMSB10/TMSB4X,TXN,UBA52,UBL5,UGCG,UQCRH,VDAC2	 	
P3	 	MYC	-1.319	transcription regulator	Activated	4.911	bias	0.278	1.607	1.06E-24	ACTB,ACTN1,AHCY,ALCAM,ALDOA,ANXA5,APP,ASNS,ASS1,ATF4,ATP13A2,BCAT1,BCL2L1,BIN1,BMPER,C12orf49,C1QBP,CAPN2,CAPNS1,CAPZB,CBX4,CCND2,CCND3,CCT3,CD151,CDK6,CITED1,CLUH,CNBP,CNP,COL15A1,COL5A2,COL8A1,COX7A2L,CSPG4,CSTB,CTNNA1,CTSB,CTSD,CYCS,DDIT3,DDX21,DKC1,DSP,DUSP1,DUSP4,DUSP6,EGR1,EIF2B3,EIF2S1,EIF2S2,EIF3G,EIF4A1,EMP1,ENO1,FAM129A,FAS,FECH,FKBP5,FLNA,FOS,FTH1,GAA,GABARAP,GAPDH,GCLM,GCSH,GFPT1,GLUL,GM2A,GOT1,GPC1,GPC3,GRPEL1,H2AFZ,HDAC2,HIF1A,HLA-A,HMGA1,HMOX1,HNRNPAB,HSD11B2,HSPA9,HSPD1,HSPE1,HSPH1,IPO7,KLF4,LAMP2,LEP,LGMN,LIMA1,LIMS1,LSM4,LYZ,MAT2A,MBP,ME2,METAP2,MGAT1,MKI67,MMP9,MT-TY,MYL9,NARS,NCAM1,NDUFS4,NME1,NME2,NPM1,OAS1,ODC1,PAICS,PAX5,PCDH18,PCK1,PEG10,PFKFB1,PFKFB3,PFKL,PGAM1,PHB,PHB2,PKM,PLAU,PLP1,PNO1,PPAT,PPIA,PSAT1,PTPRC,RAB10,RPL13,RPL19,RPL21,RPL26,RPL30,RPL35,RPL41,RPL7A,RPL9,RPLP1,RPS12,RPS16,RPS19,RRM2B,RRP1B,RUVBL1,SAE1,SDCBP,SEPHS2,SERPINA1,SERPINE2,SERPINH1,SFRP1,SHMT2,SLC16A1,SLC1A5,SLC25A5,SLC38A1,SLC3A2,SLC7A5,SNRPD1,SNRPD2,SOX17,SOX9,SPP1,SRM,SUMO3,TFRC,TGFB2,THBS1,TKT,TMSB10/TMSB4X,TSPO,TXN,TXNRD1,UBE2I,USP18,VCAM1,VDAC2,XIST	CDKN2A,CEBPB,CREBBP,ELK1,ERK1/2,ESR1,ESR2,FOS,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,beta-estradiol	
P3	 	5-fluorouracil	 	chemical drug	Inhibited	-5.231	bias	-0.299	-2.824	1.50E-23	AHSA1,ALDOA,ANXA2,ATF4,ATP5I,BCL2L1,CAPNS1,CCT3,CCT4,CES2,COPS8,COX8A,CSTB,CYCS,EEF1G,EGR1,EIF2S2,EIF3G,EIF4A1,FAS,FGFR2,FKBP1A,GAPDH,GARS,GDF15,HNRNPAB,HSP90AB1,HSPA8,HSPE1,IARS,ILF2,MAT2A,MT-CO1,NDUFA1,NDUFA4,NDUFS8,OAZ1,PKM,PSMB5,PSMB7,PSMD2,PSME1,RPL18,RPL19,RPL21,RPL24,RPL30,RPL31,RPL35,RPL37,RPL38,RPL7A,RPS13,RPS16,RPS29,RPS4Y1,RPS8,SLC25A5,SLC25A6,SNRPD2,SNRPF,SQSTM1,SRM,SSR4,TCEB2,THBS1,TMSB10/TMSB4X,TNFRSF12A,UNG,XPOT	5-fluorouracil,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,VEGFA	
P3	 	1,2-dithiol-3-thione	 	chemical reagent	Activated	6.636	bias	0.526	 	1.08E-22	ABCC3,ACTG1,ALAS1,ALDOA,ARF1,CCT3,CCT7,CREG1,CTSD,DAD1,DYNLL1,EIF2S1,EIF3G,EIF4G2,EIF6,ENTPD5,EPHX1,ERP29,FKBP5,FMO1,FTH1,GBE1,GCLM,GSPT1,GSTM5,GSTP1,HACD3,HAX1,HMBS,HMOX1,HSP90AB1,HTATIP2,LY6E,MSMO1,NARS,NFE2L2,NQO1,NUCB2,PDIA6,PPIB,PRDX1,PSAT1,PSMA4,PSMA5,PSMB5,PSMB6,PSMD14,PSMD3,PSMD7,PSMD8,RACK1,RAN,RPL18,RPLP0,RPS16,RUVBL1,SAA1,SEC61A1,SOD1,SREBF1,STIP1,TFRC,THRSP,TXN,TXNRD1,UBE2K	1,2-dithiol-3-thione,BACH1,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA	
P3	 	NFE2L2	1.798	transcription regulator	Activated	7.137	bias	0.468	2.717	4.89E-22	ABCB11,ABCC1,ABCC3,ACTG1,ADCYAP1,AKR7A2,ALAS1,ALDOA,AOX1,ARF1,ATF4,BCL2L1,CCT3,CCT7,CREG1,CTGF,CTSD,CYBB,DAD1,DCTN3,DDIT3,DYNLL1,EIF2S1,EIF3G,EIF4G2,ENTPD5,EPHX1,ERP29,FKBP5,FMO1,FTH1,FTL,GBE1,GCLM,GSPT1,GSS,GSTM4,GSTM5,GSTP1,HACD3,HAX1,HMBS,HMOX1,HSP90AB1,HSPA9,HTATIP2,IL1RN,KEAP1,LY6E,MAFG,MAPK10,ME1,MMP9,MSMO1,NARS,NFE2L1,NFE2L2,NQO1,NSMF,NUCB2,OSGIN1,PDIA6,PGD,PPIB,PRDX1,PSAT1,PSMA4,PSMA5,PSMB5,PSMB6,PSMD14,PSMD3,PSMD7,RACK1,RAN,RPL18,RPLP0,RPS16,RUVBL1,SAA1,SEC61A1,SHC1,SLC1A4,SLC7A11,SOCS3,SOD1,SQSTM1,SREBF1,STIP1,THRSP,TUB,TXN,TXNRD1,UBE2K,VCAM1	BACH1,EP300,HMOX1,IL1B,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,RELA,SP1,STAT3,TP53	
P3	 	APP	2.310	other	Activated	2.567	bias	0.254	0.750	6.84E-22	ACO2,ACTB,ACTG1,ADCYAP1,AES,AIF1,AK1,ALDOA,ALDOC,APLP2,APOE,APP,ARF6,ARL6IP5,ATF4,ATOX1,ATP5D,ATP5H,ATP6V1A,ATP6V1E1,BCL2L1,BMF,BMP6,BSG,C1QBP,CA12,CALR,CAMK2D,CCND2,CD151,CD68,CDC42,CDK6,CFL1,CLDN5,CLIC6,CLTC,CRYM,CSF1,CSF1R,CTGF,CTSB,CTSD,CXCL12,CYBB,CYCS,DNAJC5,EEF1G,EGR1,ENO1,F2RL3,FAM49A,FCGR2A,FKBP1A,FLNA,FOS,FOSB,GAPDH,GDF15,GNA12,GNB1,GNG2,GPC1,GSK3B,GSTM3,GSTP1,HINT1,HK1,HMGA1,HMOX1,HSP90AB1,HSPA5,HSPA8,HSPD1,HSPE1,JUNB,KCND3,LHFPL2,LMO4,LRP6,MAF,MAP1B,MAPKAPK2,MAPT,MBD4,MBP,MMP14,MMP9,MSR1,MT-ATP6,MT-CO1,MT-CYB,MT-ND1,MT-ND5,MTHFD1L,NCDN,NDUFA8,NDUFS4,NDUFS6,NME1,NR1D1,PACS2,PAFAH1B2,PAX5,PDGFA,PDXP,PEA15,PEBP1,PFKFB3,PGAM1,PKM,PLAT,PLAU,PPIA,PPP2R1A,PRDX5,PRKACA,PRNP,PSME1,PTPRC,RAN,RNF24,SDC4,SHC1,SIGMAR1,SIRPA,SLC7A11,SLFN5,SMARCA4,SOCS3,SOD1,SOX9,SREBF2,STIP1,STUB1,STXBP1,STXBP4,THSD4,TOP2A,TP63,TPM3,TPP1,TRAF3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UBE2K,UCHL1,UQCRQ,USP18,VCAM1,VDAC1,YWHAB	APOE,APP,CTNNB1,FOS,HIF1A,JUN,Jnk,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PSEN1,RELA,SP1,STAT3,TP53	
P3	 	dexamethasone	 	chemical drug	 	-1.632	 	0.127	-3.412	4.75E-21	AACS,ABCC1,ABCC3,ABCC6,ACTB,ACTG1,ACTR3,ADAM12,ADAM17,ADAM9,ADAMTS15,ADIPOQ,ADRA2A,AKR1C1/AKR1C2,AKR1C3,ALAS1,ALCAM,ALDH1B1,ALDH4A1,ALOX5AP,ANOS1,ANXA1,APOE,APP,ARHGDIA,ARHGEF2,ARL4C,ASNS,ATF4,ATP6V1B2,AUP1,B3GNT5,B4GALT2,BCKDK,BCL2L1,BSG,BTG2,BZW2,C1QB,C3AR1,C9orf72,CALR,CARS,CCND2,CCND3,CD209,CD83,CDH11,CEBPB,CES1,CES2,CFL1,CHI3L1,CLDN5,COL15A1,COL6A1,CPEB4,CREG1,CRISPLD2,CSF1,CSF1R,CTGF,CTSB,CTSD,CXCL12,CXCL14,CYBB,CYP1B1,CYP27A1,CYP2B7P,CYP4A11,CYR61,DDIT3,DNAJC15,DUSP1,DUSP10,DUSP4,EDEM1,EDNRB,EEF1A1,EGLN3,EGR1,EIF5,EIF6,ELOVL1,ESR2,ETF1,ETV5,FAM129A,FANCE,FKBP2,FKBP4,FKBP5,FMO1,FOS,FOSB,FST,FSTL3,FTH1,FTL,G0S2,GAPDH,GBP1,GCLM,GDF15,GEM,GLUL,GOT1,GPC3,GPR65,GRN,GSTM3,GSTM5,GSTP1,GUK1,HADHB,HCST,HDAC2,HLA-A,HMGA1,HMOX1,HNRNPAB,HOXA7,HPGDS,HSD11B2,HSPA5,HSPA8,HSPH1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL1RN,ILF2,IP6K3,IRAK1,ITGAV,IVD,JUNB,KCNK2,KIT,LAGE3,LAMA2,LAPTM5,LEP,LITAF,LMO4,LPAR1,LPIN2,LRP8,LY6E,MAF,MAT2A,MBP,ME1,MFAP5,MID1IP1,MMP14,MMP9,MRPL47,MSR1,MT1M,MYOC,NAGA,NCAM1,NDUFA4L2,NFE2L1,NFKBIZ,NHLH1,NPM1,NR1H3,NR2F6,NR4A1,NUCB2,ODC1,OLFML2B,P4HA1,P4HA2,PCBD1,PCDH19,PCK1,PCK2,PDGFA,PEBP1,PFKFB3,PHLDA2,PLAT,PLAU,PLEK,PLIN1,PLOD2,PLOD3,PNRC2,POMGNT1,PRELP,PSAP,PTX3,RAB4A,RARRES3,RCC2,RET,ROR1,RPL26,RPLP0,SAA1,SAA2,SCD,SDHC,SEC61A1,SERPINA1,SERPINE2,SFRP1,SHB,SHC1,SLC25A1,SLC25A5,SLC27A4,SLC2A5,SLC4A7,SLC9A1,SMOC2,SOCS3,SOD1,SOX9,SPP1,SREBF1,SRM,SRPRA,STON1,TACR1,TAF6,TGFB2,THBS1,THRSP,TMEM176B,TNS1,TOP2A,TSN,TSPAN33,TWF1,TWF2,TXN,UBE2D2,UCP2,UGCG,USP18,VCAM1,WARS,WDR1,ZBTB16	CEBPA,CEBPB,CREBBP,HIF1A,IGF1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TGFB1,TNF,dexamethasone,troglitazone	
P3	 	HNF4A	-17.187	transcription regulator	 	0.353	 	0.240	-0.895	2.18E-20	AASS,ABCB11,ABCC3,ABCC6,ACAD8,ACO2,ACP2,ACSS3,ACTN1,ACTR1A,ACTR3,ADGRB2,ADPRH,AGPAT1,AHSA1,AKR1B1,AKR1C1/AKR1C2,AKR1C3,ANXA5,APOB,APOC1,APOE,ARFGAP1,ARL4C,ARPC5,ATF4,ATG9A,ATP10A,ATP6V0C,ATP6V1F,BAG6,BCL2L1,BPIFB2,C11orf68,C12orf49,C1orf123,CAMK2D,CBX3,CBX5,CDK2AP2,CDKN2AIPNL,CEBPB,CES2,CETN2,CHCHD2,CHD1L,CHI3L1,CLDN2,CLPTM1,CMC2,CMSS1,CNBP,COPB1,COPS7A,COPS8,COX14,COX7A2L,COX8A,CRAT,CREBL2,CTDNEP1,CTSA,CTSB,CYP1B1,CYP27A1,DAD1,DDX49,DERL1,DPM1,DPM2,DUSP3,DUSP6,EAF1,EGR1,EIF5,EMG1,EPHX1,EXOSC5,FARSB,FAS,FH,FHL1,FIG4,FKBP3,FLNA,FLOT1,G0S2,GAPDH,GBE1,GDF15,GHITM,GIN1,GJB2,GLYAT,GNG5,GNL3,GOT1,GSK3B,GSPT1,GSS,GSTM4,GUF1,HADHB,HEXA,HIF1A,HLA-G,HNRNPA0,HSPA5,HSPE1,HSPH1,IFI30,IGSF8,IL10RA,IL11RA,IMMT,JTB,JUNB,KIF3B,LBHD1,LIMS1,LIPA,LPCAT3,LSM3,LSM4,MAL2,MAPK8IP2,MAT2A,MBD4,MDH2,METAP2,MICU1,MID1IP1,MLH1,MOCOS,MRPL24,MRPL37,MRPL43,MRPL51,MRPS15,MRPS7,MTMR2,NAA10,NAA38,NAGA,NDUFA1,NDUFA4,NDUFS4,NFE2L1,NME1,NOP16,NPC1L1,NR1D1,NR1H3,NR2F1,NR5A2,NUAK1,NUTF2,OGDH,OSBPL11,PCBD1,PCK1,PCK2,PEG10,PHB,PHB2,PHPT1,PI4KB,PKM,PLAA,PNMA1,PNO1,POLE3,PPFIBP2,PPIL1,PPIP5K2,PPP1R11,PPP1R3C,PRAF2,PRDX5,PRELID3B,PRKCE,PSAT1,PSMA3,PSMA5,PSMB5,PSMB7,PSMC4,PSMD10,PSMD7,PSMD8,PSME3,R3HDM1,RAB10,RAB7A,RASL12,RBM18,REXO2,RMND1,RNPEPL1,RPAP3,RPL12,RPL18,RPL18A,RPL31,RPL41,RPLP1,RSL24D1,SAA1,SAA2,SCAND1,SCD,SEL1L,SERPINA1,SESN2,SF3B5,SGSH,SLC19A3,SLC25A1,SLC25A13,SLC25A5,SLC31A1,SLC33A1,SLC38A1,SLC39A1,SLC39A6,SLC5A3,SNRPD2,SNRPD3,SOX17,SOX9,SP2,SPATS2L,SPP1,SREBF2,SRPRA,SRPRB,SRR,SSU72,STAM,STARD7,STIM1,STOML2,STT3A,SUPV3L1,TAF6,TARS,TBC1D16,TCF7,TENM4,TMBIM6,TMEM123,TMEM126B,TMEM176A,TMEM176B,TMEM208,TMEM33,TMEM43,TMX2,TRIM55,TRMT112,TRUB2,TSN,TXNDC12,TXNL1,TXNRD1,UBA5,UBQLN1,UCHL1,UCP2,UROS,USMG5,USP5,UTP11,VAMP5,VDAC1,VDAC2,VKORC1,WARS2,WDR12,XPNPEP2,YIF1A,YWHAB	FOXO1,FOXO3,HNF1A,HNF4A,INS,PPARA,SP1,SREBF1	
P3	 	tretinoin	 	chemical - endogenous mammalian	 	1.947	 	0.245	-1.245	2.93E-19	ADAMTS5,ADCYAP1R1,ALAS1,ALDH1A2,ALK,ALPL,ANXA1,ANXA2,ANXA5,APOE,APP,ASNS,ATF4,ATP6V1B2,BCL2L1,BMP6,BTG2,C1QA,C3AR1,CALM1 (includes others),CALR,CAPN2,CCND2,CCND3,CCPG1,CCT5,CD14,CD300C,CD52,CD53,CD63,CD68,CDC42,CDK6,CEBPB,CEBPG,CES1,CFTR,CIDEA,CLTC,CNR1,CRAT,CREG1,CSE1L,CSF1R,CSRNP1,CTGF,CTSB,CTSD,CTSS,CUBN,CYBB,CYP4A11,CYP4B1,CYR61,DAB2,DAD1,DAPK2,DDIT3,DHRS9,DSP,DUSP1,DUSP4,DYNLL1,EEF1A1,EEF1G,EFNB1,EFS,EGR1,EIF4A1,EIF5,EIF6,EPHX1,FARSB,FASTK,FCER1G,FLRT1,FOLR2,FOS,FST,G0S2,GARS,GDE1,GDF15,GM2A,GNA12,GNA13,GSTP1,HK1,HLA-A,HMGA1,HMOX1,HNRNPK,HOXB5,HSPA2,HSPD1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IMPDH2,ISLR,ITGB2,IVD,KIT,LAMP2,LGALS9,LIPA,LTF,LY6E,MAP1B,MAP2K3,MAPK10,MAPKAPK2,MARCKSL1,MECOM,MLF2,MLH1,MMP14,MMP9,MNAT1,MSC,NAA10,NCAM1,NDUFA13,NDUFB7,NID2,NME2,NPM1,NR2F1,NTRK3,OAS1,ODC1,P4HA2,PCK1,PEG10,PFN1,PGD,PLAT,PLAU,PLCB2,PLCE1,PLEK,PLEKHO2,PLIN2,PLOD3,PLP1,POR,PPP1R16B,PPP1R1B,PRNP,PSMB10,PSMC4,PTP4A3,PTPRC,PTX3,RAD23B,RALA,RAN,RARRES3,RET,RNASE1,ROR1,RPL13,RPL4,RPS12,RPS16,RPS19,RPS3,RPS4Y1,RUVBL1,SCD,SDCBP,SEPHS1,SERPINE2,SFRP1,SHANK2,SIRPA,SLC16A1,SLC5A3,SLC6A6,SLC7A2,SLFN5,SMARCA4,SMPD3,SNRPD3,SOD1,SOX17,SOX9,SPP1,SREBF1,STT3A,TAF6,TFRC,TGFB2,THBS1,THRA,THSD4,TIAL1,TMSB10/TMSB4X,TNFRSF1A,TOP2A,TPP1,TSPAN33,TYROBP,UCP2,USP18,VCAM1,VSIG4,WSB1,XRCC6,YPEL1,YWHAB,ZBTB16	APOE,CEBPA,CEBPB,CSF3,CTNNB1,EGF,IFNG,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,STAT5B,TNF,TP53,tretinoin	
P3	 	D-glucose	 	chemical - endogenous mammalian	 	0.086	 	0.149	-1.309	9.51E-19	AARS,ACO2,ACTB,ADAM17,ADIPOQ,AKR1B1,ALDOA,ALDOC,ANLN,ANXA1,APOB,ASNS,ASS1,ATF4,ATF5,BCAT1,BCL2L1,CALR,CARS,CCND2,CCND3,CCPG1,CEBPB,CLGN,CNR1,CTGF,CTSB,CYBB,DDIT3,EGR1,ENO1,FAS,FKBP2,FOS,FST,G6PC3,GAPDH,GDF15,GFPT1,GLUL,GOT1,GRN,HIF1A,HK1,HMOX1,HNRNPK,HSPA5,HSPD1,JUNB,LEP,MDH2,MID1IP1,MMP14,MMP9,MSR1,MT-ND1,NDUFA1,NDUFB9,NFE2L2,NPY1R,NQO1,NR4A1,NUAK1,ODC1,PCCB,PCK1,PCK2,PDIA6,PFKFB3,PFKL,PGAM1,PHB,PPIB,PREB,RTN3,SARS,SCD,SEC61A1,SEPHS2,SHC1,SLC25A1,SLC25A11,SLC25A5,SLC33A1,SLC39A6,SLC3A2,SLC7A1,SORBS1,SOX9,SPP1,SQSTM1,SREBF1,SRM,SRPRA,STUB1,STXBP1,TALDO1,TFRC,THBS1,THRSP,TKT,TXNRD1,UCP2,VCAM1,WARS,YARS	AKT1,CEBPA,CEBPB,D-glucose,FOXO1,Insulin,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF,TP53,palmitic acid	
P3	 	PSEN1	1.369	peptidase	Inhibited	-2.824	 	-0.081	-2.416	1.40E-18	ABCC6,ACO2,ACTB,ACTG1,ALDOA,APOE,APP,ARF6,ATOX1,ATP5D,ATP5H,ATP6V1A,ATP6V1E1,BSG,C1QA,C1QB,C1QBP,C1QC,C3AR1,CAMK2D,CFL1,CLTC,COX8A,CRYM,CTSS,CYCS,DGKE,DNAJC5,DUSP1,EEF1G,EGR1,EMP1,ENO1,FKBP1A,FOS,GAPDH,GAS5,GNA12,GNB1,GNG2,GSTP1,HINT1,HK1,HSPA5,HSPA8,HSPD1,HSPE1,KIF5B,LFNG,LRP8,MAPT,MBP,MMP9,MSR1,MT-CO1,MTHFD1L,NCAM1,NCSTN,NDUFA8,NDUFS4,NDUFS6,NME1,NUPR1,PAFAH1B2,PEA15,PEBP1,PGAM1,PKM,PPIA,PRDX5,SOD1,STAB1,STIP1,STXBP1,TNXB,TPM3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UCHL1,UQCRQ,VDAC1,WARS	APP,ETS2,FOS,HIF1A,HSF1,JUN,MTOR,MYC,NFE2L2,NFKB1,NFkB (complex),NR3C1,PSEN1,RELA,SIRT1,SOD1,SP1,STAT3,TP53	
P3	 	TGFB1	1.871	growth factor	Activated	5.179	 	0.243	2.187	3.07E-18	AASS,ACSL3,ACTN1,ADAM12,ADAM17,ADIPOQ,ADRA2A,AK1,AKR1C1/AKR1C2,ALDH3A2,ALOX5AP,ANXA2,APOB,APOE,APP,ARHGAP35,ASNS,ASS1,ATF4,BCL2L1,BIN1,BMF,BMP6,BSG,C1QA,C1QB,C1QC,C20orf24,C3AR1,CALM1 (includes others),CAPNS1,CARS,CCDC85B,CCND2,CCND3,CCT5,CD14,CD28,CD4,CD68,CD83,CDH11,CDK2AP1,CEBPB,CFL1,CHI3L1,CHST11,CNIH1,COL16A1,COL6A1,COL8A1,COX5A,CSF1,CSF1R,CSPG4,CTGF,CTPS1,CTSB,CTSD,CTSS,CXCL12,CYBB,CYC1,CYR61,DAB2,DAD1,DDX21,DES,DKC1,DKK3,DNPEP,DSP,DTX4,DUSP1,DUSP4,DYNLL1,EDNRB,EEF1A1,EGR1,EPRS,ESR2,F13A1,FAS,FCER1G,FGFR2,FHL1,FLNA,FLRT1,FOS,FOSB,FSCN1,FSTL3,FTH1,FTL,GABBR1,GARS,GBP1,GDF15,GEM,GIN1,GJB2,GLRX2,GNA13,GNG2,HCST,HDAC2,HEXA,HIF1A,HINT1,HLTF,HMGA1,HMOX1,HOXB5,HSPA5,IARS,ID4,IFI30,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL1RN,ITGAV,ITGB2,JUNB,KCNG1,KIT,KLF2,KLF4,KLRD1,LASP1,LEP,LIMS1,LITAF,LPAR1,LPCAT3,MAF,MAP2K3,MAPKAPK2,MFAP4,MGAT5,MKI67,MMP14,MMP9,MRPS6,MSMO1,MSR1,MVD,MYL12A,NAB2,NCAM1,NDUFS4,NME1,NNMT,NPAS2,NPTXR,NR1H3,NR4A1,NRBP1,NUAK1,NUCB2,NUPR1,P4HA1,PCCB,PDGFA,PHLDA2,PLAT,PLAU,PLOD2,PNO1,PPFIBP2,PPP1R1B,PPP1R3C,PPT1,PTPRC,PTPRK,RAB1A,RACK1,RAD51C,RAPGEF3,RHOD,RNH1,ROR1,RPN2,S100A11,SAE1,SCD,SDC4,SEMA3B,SERPINA1,SERPINE2,SERPINH1,SFRP1,SGSH,SLC12A7,SLC20A1,SLC39A1,SLC4A2,SLC52A2,SLC7A1,SLC7A5,SMOC2,SOCS3,SOX9,SPP1,SRM,SRR,STC2,STOML2,TAX1BP3,TENM4,TFRC,TGFB2,THBS1,TMEM184B,TNFRSF12A,TOP2A,TPM3,TPSAB1/TPSB2,TPST2,TRIM2,TUBB2A,TUBB4B,TXNRD1,TYMP,UST,VAT1,VCAM1,VDAC2,VPS11,VPS28,WNT5B,XPNPEP2,XYLT1	CEBPA,CEBPB,CREBBP,ELK1,ESR1,IFNG,IL1B,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TGFB1,TNF,TP53	
P3	 	TP53	1.713	transcription regulator	Activated	2.671	 	0.149	0.794	8.95E-18	ABCC1,ABHD4,ACO2,ACP2,ACSL3,ACTB,ACTN1,AHCY,AHSA1,AIFM2,AK1,AKR1B1,ALDH1A2,ALDH4A1,ANLN,ANXA1,ANXA2,AP1B1,APOE,APP,ARHGEF2,ARPC1B,ASNS,ASS1,ATF4,BCAP31,BCL2L1,BHLHE41,BMF,BTG2,C1QC,CAMK2D,CAPNS1,CARS,CCND2,CCND3,CEBPB,CEP170B,CES2,CISD1,COL5A2,COMT,COPB1,CSF1,CSF1R,CSTB,CTGF,CTSB,CTSD,CXCL12,CYR61,DDIT3,DHRS9,DKK3,DUSP1,DUSP4,DUSP6,EDIL3,EGR1,EIF4E2,EPHX1,F5,FAS,FHL1,FKBP1A,FKBP3,FKBP4,FKBP5,FMO1,FOS,FSTL3,GAPDH,GBP1,GDF15,GLB1,GLUL,GNA13,GNL3,GSK3B,GSTM5,GSTP1,H2AFZ,HADHB,HDAC2,HIF1A,HMGCS1,HMOX1,HRAS,HSP90AB1,HSPA8,HSPD1,HSPH1,HYAL1,IFI30,IGFBP3,IGFBP4,IL10RA,IPO7,IRF8,JUNB,KCNG1,KCNMA1,KIT,KLF4,LASP1,LIMA1,LYZ,MAPRE3,MCAM,MDH2,ME1,ME2,MICALL1,MKI67,MLF2,MLH1,MMP9,MOCOS,MT-CYB,MT-ND5,MVD,MYL9,NAP1L4,NARS,NDUFA4L2,NEO1,NID2,NINJ1,NME1,NPM1,NR2F1,NR6A1,NUPR1,OAS1,OSGIN1,P4HA1,PAFAH1B2,PARK7,PCDH7,PCK1,PCNXL2,PDGFA,PDIA6,PDRG1,PEG10,PFKFB3,PFN1,PHLDA3,PLAU,PLOD2,PLTP,POLD2,PPT1,PRKCE,PRNP,PSAP,PSMD2,PSMD3,PSMD8,PSME3,PTP4A3,PYCARD,RAD23A,RAP2B,RARRES3,RPN1,RPN2,RPS27L,RPSA,RRM2B,SCO2,SEC23B,SEC61A1,SEL1L,SERPINE2,SERPINH1,SESN2,SFRP1,SFRP2,SGPL1,SHC1,SLC16A1,SLC5A3,SLC6A6,SOD1,SORBS1,SPP1,SREBF1,STEAP3,STIP1,TGFB2,THBS1,TMEM127,TMEM43,TMSB10/TMSB4X,TOP2A,TP63,TPP1,TRIB3,TRIM28,TSPO,TUBB,UNC5B,UNG,VAPA,WNT5B,WSB2	CEBPA,CEBPB,ERBB2,FGF2,FOXO3,HIF1A,IFNG,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TNF,TP53,estrogen receptor	
P3	 	MAPT	1.743	other	 	-0.816	 	0.047	-0.932	1.11E-17	ACO2,ACTG1,AIF1,ALDOA,APP,ARF6,ATOX1,ATP5D,ATP5H,ATP6V1A,ATP6V1E1,BSG,C1QBP,CAMK2D,CFL1,CLTC,CRYM,CYCS,DNAJC5,EEF1G,ENO1,FKBP1A,FOS,GAPDH,GEM,GNA12,GNG2,GSTM5,GSTP1,HINT1,HK1,HSPA5,HSPA8,HSPD1,HSPE1,MAP1B,MAPT,MBP,MTHFD1L,NDUFA8,NDUFS4,NDUFS6,NME1,PAFAH1B2,PCLO,PEA15,PEBP1,PGAM1,PKM,PPIA,PRDX5,PRNP,SOD1,STIP1,STUB1,STXBP1,TPM3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UCHL1,UQCRQ,VDAC1	APP,ELK1,HIF1A,JUN,MAPT,MTOR,MYC,NFE2L2,NFKB1,NFkB (complex),NR3C1,PSEN1,RELA,SIRT1,STAT3,TP53,nitric oxide	
P3	 	dihydrotestosterone	 	chemical - endogenous mammalian	Activated	2.686	bias	0.343	0.338	3.86E-17	ACO2,ACTB,ADCYAP1,ADIPOQ,AES,ALAS1,ALDOA,APOE,APP,ASAP2,ATP13A2,BCAP31,BCL2L1,BMF,BTG2,CCND2,CCND3,CCNI,CCT3,CD63,CHI3L1,CLIC6,COL5A2,COL5A3,COL6A1,CTGF,CYBB,CYP4A11,CYP4B1,DPM3,DYNLL1,EGR1,ENO1,ESR2,FKBP5,FOS,FST,FTH1,FTL,G0S2,GAPDH,GLUL,GRN,GSTP1,HINT1,HLA-A,HMGN1,HPGDS,HSD11B2,IGFBP3,IGFBP4,KPNA1,LEP,LY6E,LYZ,MAF,MARK1,MCAM,ME1,MED16,MT-CO1,MT-CYB,NID2,NR4A1,ODC1,PCK1,PEA15,PFN1,PHB,PLAU,PRNP,RAD23A,RPL12,RPL19,RPL28,RPL30,RPL37A,RPL8,RPL9,RPS12,RPS24,RPS29,RPS4Y1,SCD,SDC3,SEL1L,SERPINE2,SHC1,SLC1A4,SLC1A5,SLC2A5,SLC3A2,SLC4A4,SLC4A7,SPP1,SREBF1,SREBF2,STXBP1,TALDO1,TFPI,TGFB2,THBS1,TKT,VCAM1	AGT,Akt,CTNNB1,EGF,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TCF7L2,TP53,dihydrotestosterone	
P3	 	ATF4	2.287	transcription regulator	Activated	5.129	bias	0.594	 	6.05E-16	AARS,ASNS,ATF4,ATF5,BCAT1,CALR,CEBPB,CEBPG,CHAC1,DDIT3,EIF2S2,GARS,GDF15,GHITM,GYS1,HSPA5,IARS,KLF4,MARS,MID1IP1,MRPS7,NARS,NID2,NR1H3,NUPR1,PCK1,PCK2,PSAT1,PTX3,SARS,SEL1L,SHMT2,SIGMAR1,SLC1A5,SLC38A3,SLC3A2,SLC7A1,SLC7A5,SREBF1,STC2,TNFRSF12A,TRIB3,WARS,XPOT	ATF4,CEBPA,CEBPB,CTNNB1,DDIT3,FOXO1,Ins1,NFKB1,PPARA,PPARG,RELA,SREBF1,STAT3	
P3	 	TNF	1.306	cytokine	Activated	4.351	bias	0.258	0.838	1.42E-14	ABCB11,ABCC1,ABCC3,ABR,ACTB,ADAM17,ADAMTS5,ADAMTS8,ADIPOQ,AKR1B1,ALCAM,ALOX5AP,ANXA1,APOE,APP,ARL6IP5,ASS1,ATF4,BCL2L1,BHLHE41,BIRC7,BMPER,BTG2,BTG3,C3AR1,CALR,CCND2,CCND3,CD14,CD209,CD28,CD4,CD83,CDC42,CDH11,CEBPB,CEBPG,CFTR,CHI3L1,CHST11,CHST2,CNP,COL15A1,COL16A1,CPA3,CSF1,CSF1R,CTGF,CTSB,CTSS,CXCL12,CXCL16,CYBB,CYP1B1,CYP27A1,CYR61,DDIT3,DUSP1,DUSP10,DUSP4,DUSP6,DVL1,EDNRB,EGLN3,EGR1,EMP1,ENTPD5,ETV5,F2RL3,FAS,FCER1G,FGFR2,FMO1,FOS,FOSB,FSCN1,FST,FTH1,G0S2,GBP1,GCLM,GDF15,GEM,GM2A,GRN,GSK3B,GSPT1,GSTP1,HEXA,HIF1A,HLA-A,HMOX1,HPGDS,HSP90AB1,HSPA4,HSPA8,HSPD1,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL1RN,IRF8,ITGAV,ITGB2,JUNB,KCTD13,KIT,KLF2,KLF4,LEP,LGALS9,LITAF,LRP6,LRRC8D,MAP2K3,MAP4K4,MARCKSL1,MAT2A,MBP,MCAM,MECOM,MMP14,MMP9,MPC1,MSC,MSR1,MT-CYB,NAGLU,NCAM1,NFE2L2,NFKBIZ,NINJ1,NME1,NNMT,NQO1,NR1H3,NR4A1,NR5A2,NR6A1,NUAK1,NUCB2,OAS1,ODC1,OLFML2B,PCDH7,PCK1,PCK2,PDGFA,PKM,PLAA,PLAT,PLAU,PLD3,PLIN1,PLIN2,PLOD2,PLP1,PPIF,PPP1R3C,PPP2R1B,PRNP,PSMB10,PSME1,PTGFR,PTPRC,PTX3,PYCARD,RAB32,RARRES3,RCN3,RNASE1,RPS11,RPS13,RPS3,RPSA,RRM2B,SAA1,SCD,SCO2,SCUBE1,SDC4,SERPINE2,SFRP1,SLC1A4,SLC20A1,SLC7A1,SLC7A2,SMPD2,SNCG,SOCS3,SOD1,SORBS1,SOX9,SPP1,SQSTM1,SRA1,SREBF1,ST3GAL6,TALDO1,TFPI,TFRC,TGFB2,THBS1,THRSP,TIE1,TMEM176B,TNFRSF1A,TPO,TRAF3,TREM2,TUB,TXN,TXN2,TXNRD1,TYMP,UCP2,UGCG,UTP11,VCAM1,WHSC1,YWHAG,ZNF330	CEBPB,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	genistein	 	chemical drug	Activated	4.014	 	0.204	2.286	5.93E-14	ACP2,AKR1C3,ALAS1,AP1B1,APOB,ARSA,ATP6AP1,ATP6V0B,ATP6V0D1,ATP6V1A,BCL2L1,BIRC7,BTG3,CD4,CD68,CFTR,CLCN7,CLN5,CTGF,CTSA,CTSB,CTSD,CTSG,CXCL12,DNASE2,DUSP1,ESR2,FERMT3,FOS,GABARAP,GBA,GDF15,GFPT1,GJB2,GLB1,GM2A,HCST,HEXA,HIF1A,HLA-A,HMOX1,HOXA10,HS2ST1,HSPA5,ITGB2,JUNB,KLRD1,LAPTM5,LGMN,LIPA,LTF,MAL2,MAP3K1,MMP9,MMRN1,NAGLU,NFE2L2,NR1H3,OGDH,PLAT,PLBD2,PLCXD3,PLTP,PPT1,PSAP,RPH3A,RPN2,RRAGC,SGSH,SLC1A5,SLC36A1,SLC4A4,SPP1,SQSTM1,TFEB,TPP1,VCAM1,VPS11,XYLT1	CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SRC,STAT3,TFEB,genistein	
P3	 	FOS	-5.092	transcription regulator	Activated	2.706	 	0.198	1.334	2.61E-13	ABCC1,ACTG1,ADAM12,AKR1C3,ALAS1,AP3D1,APLP2,ARF1,ARPC5,C3AR1,CAMK2D,CAPN2,CD14,CD68,CDON,CHI3L1,CLDN2,CLIP1,COL16A1,COL6A1,CSTA,CTGF,CTSB,CXCL16,CYCS,DAPK2,EGR1,EIF4G2,ENAH,ENO1,FOLR2,FOS,FOSB,FTH1,GAS5,GBA,GM2A,GSK3B,GSTP1,HMOX1,HPGDS,HSPA5,HSPB8,HTATIP2,JUNB,KIF5B,LAMP2,LPCAT3,LRP8,MAP4K4,MLH1,MMP9,MMRN1,NFE2L2,NQO1,NR5A2,ODC1,PCDH19,PCYT2,PFN1,PKN1,PLAT,PLAU,PRDX1,PRKCE,PTP4A2,PXK,RAPGEF3,RFNG,RGMA,RNH1,RPL9,RPLP0,RPS24,SCD,SDK1,SEC23B,SEMA3B,SEMA3E,SERPINE2,SFRP2,SIRPA,SNCG,SOCS3,SPP1,STIM1,TACR1,TBCA,TCEA1,TPP1,TUBB,TXN,UGCG,VCAM1,XYLT1	BACH1,EP300,ETS1,FOS,JUN,KEAP1,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	SYVN1	1.516	transporter	Activated	4.765	bias	0.668	 	3.30E-13	ABCC3,ACP2,ACSL3,ADAM9,AES,APLP2,APP,ATP6AP1,BCAT1,CALM1 (includes others),CD151,CSPG4,CTPS1,CYP1B1,DAB2,DUSP1,GANAB,HLA-A,ITGAV,MCAM,NFE2L2,PFN1,PVR,RAB10,RPL18,RPN2,SCARA3,SLC16A1,SLC1A5,SLC20A1,SLC27A3,SLC30A1,SLC3A2,SLC4A7,SLC6A6,SLC7A2,SLC7A5,TARS,TFRC,USP5	 	
P3	 	methylprednisolone	 	chemical drug	 	1.275	 	0.143	0.066	4.14E-13	ADAM17,AHCY,AKR1C3,AKR7A2,ALAS1,ALDH3A2,ANXA1,ANXA2,ASNS,ASS1,ATIC,C1QB,C1QBP,CIDEA,CNP,COMT,CREG1,CSNK2B,CTGF,CTSS,CYB5B,CYBB,CYC1,CYCS,DAB2,DHRS9,DUSP1,DUSP6,DYNLL1,EDNRB,EMP1,EPHX1,FARSA,FCGR2A,FKBP4,FOS,G0S2,GCLM,GNL3,GOT1,GPC1,GSTP1,HACD3,HMBS,HMOX1,HSPH1,IGSF6,IL1RN,IVD,LIPA,MAP3K1,ME1,MGAT1,MMP9,NDUFV3,NFE2L2,NME1,NPM1,NR1H3,NUPR1,ODC1,PCYT2,PGAM1,PHLDA2,PLAA,PLAT,PLAU,PLIN2,POR,PRKACA,PSAT1,PTER,PTPRC,RAB38,RABEP1,RUVBL1,SDC4,SEPHS2,SERPINA1,SIRPA,SLC12A7,SLC16A1,SLC25A11,SLC30A1,SLC39A1,SLC4A4,SLC4A7,SLC7A2,SMPD3,TFRC,TMSB10/TMSB4X,TOP2A,TUBA1C,UGCG,VCAM1	CEBPA,CEBPB,EP300,ERK1/2,IFNG,IGF1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT3,TP53,methylprednisolone	
P3	 	ESR1	-1.268	ligand-dependent nuclear receptor	 	-0.525	 	0.099	-1.630	4.91E-13	AASS,ABCB11,ABCC3,ADAM17,ADCY1,AES,AK1,ALCAM,ALK,ANLN,ANO2,AP2S1,APOE,ARFGAP1,ARHGEF2,ARPC5L,ASS1,ATF5,ATP6V0D1,ATP6V1A,BCAT1,BCL2L1,BIN1,CAPN2,CARM1,CCND3,CCNI,CCPG1,CD83,CDC42,CDK6,CEBPB,CEBPG,CHST2,CLCN3,CLDN2,CLIC6,COL16A1,COL5A2,COL8A1,COMT,COPE,COPG1,CPM,CTSB,CTSD,CTSS,CXCL12,CYP1B1,DAB2,DDX21,DNAJC1,DUSP10,DUSP4,EGR1,EIF5A,ENAH,ENO1,ERBB4,ESR2,FAM102A,FAS,FGFR2,FHL1,FIBP,FIS1,FKBP4,FLNA,FOS,FOSB,FST,GCSH,GEM,GJB2,GLB1,GM2A,GNA12,GNA13,GNB1,GNG12,GULP1,HAX1,HIF1A,HLA-G,HPGDS,HPS1,HSPA13,HSPA2,HSPD1,HSPH1,HYAL1,IGFBP3,IGFBP4,IMPDH2,IPO7,JUNB,KCNMA1,KCTD13,KIF3B,KIF5B,LAPTM5,LEP,LIMA1,LTF,MAP1B,MAP3K1,MAPT,MARK1,MINOS1,MKI67,MMP9,MPC1,NLK,NME1,NQO1,NR1D1,NR1H3,OTUB2,PCBD1,PCDH18,PDCD5,PHB,PHB2,PLAU,PLCE1,PLIN2,PLOD2,POR,PPP1R3C,PPP2R1A,PSAT1,PSMD3,PTP4A2,PTX3,PVR,RAB5C,RABEP1,RALA,RERG,SEMA3B,SHANK2,SIAH2,SLC16A1,SLC1A4,SLC35B4,SLC3A2,SLC4A5,SLC6A6,SLC6A8,SLC7A1,SLC7A11,SLC7A2,SLC7A5,SOX9,SPP1,SPRY4,SQSTM1,SRM,STC2,SULF1,TESK1,TFRC,TGFB2,TIMM13,TMEM2,TMOD1,TNPO1,TRIB3,TRIM16,TSPO,UHMK1,UQCR10,VPS11,VPS28,WARS,YARS,YIPF2,YPEL1,ZBTB7B	4-hydroxytamoxifen,CREB1,E2F1,ESR1,ESR2,HIF1A,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,beta-estradiol,estrogen	
P3	 	lipopolysaccharide	 	chemical drug	Activated	4.832	bias	0.364	-0.081	7.08E-13	ABCB11,ABCC1,ABCC3,ABCC6,ADIPOQ,ADRA2A,ALCAM,ALOX5AP,ANXA1,ANXA5,ANXA7,APOB,APOC1,APOE,APP,ARL4C,ARPC1B,ASS1,ATP5G1,ATP6AP1,ATP6V0D1,BAG3,BCL2L1,BSG,C3AR1,CALM1 (includes others),CALR,CAPN2,CCND2,CCNI,CD14,CD209,CD28,CD4,CD53,CD83,CDH11,CEBPB,CFTR,CHI3L1,CLDN5,COL5A2,COL5A3,COL6A1,COX4I1,COX7A1,CSF1,CSF1R,CSPG4,CSTB,CTGF,CTSB,CUBN,CXCL12,CXCL14,CXCL16,CYBB,CYCS,CYP27A1,CYP4A11,CYR61,DDIT3,DKK3,DUSP1,DUSP4,EGR1,ENO1,ETV5,FAS,FCER1G,FOS,FOSB,FSCN1,FST,FTH1,FYB,G0S2,GABARAP,GBP1,GEM,GJB2,GLIS2,GPC4,GSTP1,HADHB,HIF1A,HLA-A,HMGA1,HMOX1,HSPA5,HSPA8,HYOU1,IGFBP3,IGFBP4,IGSF6,IL10RA,IL1RN,IL20RB,IRAK1,IRF8,ITGA8,ITGAV,ITGB2,JUNB,KIT,KLF2,KLF4,LASP1,LEP,LGALS9,LIMS1,LIPA,LITAF,LPAR1,LPIN2,LTF,LYNX1,LYZ,MAF,MAP4K4,MAPT,MARCKSL1,MKI67,MMP14,MMP9,MSC,MSR1,MT-CO1,MYL9,NFKBIZ,NID2,NNMT,NQO1,NR1H3,NR4A1,NR5A2,NUPR1,OAS1,ODC1,P4HA1,PANX1,PARK7,PAX5,PCDH7,PDGFA,PFKFB3,PHLDB2,PIK3AP1,PLAA,PLAT,PLAU,PLEK,PLIN2,PPIA,PPP1R16B,PRDX1,PRDX5,PRKACA,PSMB10,PSME1,PTGES2,PTX3,PYCARD,RAB20,RAN,RARRES3,SAA1,SAA2,SCUBE1,SDC4,SERPINA1,SERPINE2,SERPINH1,SIRPA,SLC1A5,SLC30A1,SLC39A6,SLC3A2,SLC7A11,SLC9A1,SNX12,SOCS3,SOD1,SPP1,SREBF1,STIM1,STS,STXBP1,TALDO1,TFPI,TFRC,TGFB2,THBS1,THRA,THRSP,TKT,TMSB10/TMSB4X,TNFRSF1A,TOLLIP,TOP2A,TP63,TRAF3,TREM2,TSPO,TUBB4B,TWF2,TXN,TYMP,TYROBP,UBE2I,UCHL1,UCP2,USP18,VCAM1,VSIG4,WARS,YWHAG	CEBPA,CEBPB,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53,lipopolysaccharide	
P3	 	EIF2AK3	1.063	kinase	 	1.249	bias	0.575	 	7.25E-13	AARS,ASNS,ATF4,ATF5,BTG2,CARS,CBX4,CEBPB,CEBPG,CLCN3,DDIT3,EGR1,EPRS,FBXO8,HSPA5,HSPA9,IARS,KLF4,LMO4,LONP1,MECR,NARS,NUPR1,PCK2,SARS,SEL1L,SHMT2,SIAH2,SLC1A4,SQSTM1,TARS,WARS,YARS	ATF4,EIF2A,EIF2AK3,ERN1,ESR1,FOXO1,FOXO3,HIF1A,MXI1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53,TSC2,XBP1	
P3	 	valproic acid	 	chemical drug	 	-1.366	 	0.014	-1.473	8.65E-13	AACS,ADCY1,ADRM1,AGPAT1,AKR1B1,AKR1C3,AMFR,ATF4,ATP5I,BCL2L1,CA12,CALR,CARM1,CCND2,CD151,CD209,CD83,CRAT,CTPS1,CTSB,CYP1B1,CYP4A11,CYR61,DDIT3,DPM2,EDEM1,EIF2S1,FAS,FSCN1,GLUL,HIF1A,HMGCS1,HMOX1,HSPA5,KIT,LAGE3,LEP,LIMA1,LRP8,MAPK10,MRPS2,MSMO1,MVD,NCAM1,NME1,PDIA6,PLAT,PLTP,POMP,PSMA3,PSMA4,PSMA5,PSMB10,PSMB5,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD3,PSMD7,PSMD8,PSME1,PSME3,PSMF1,PTX3,RBBP8,RERG,RNPEP,ROR1,SCD,SEL1L,SERPINH1,SIAH2,SPP1,SREBF1,THBS1,THRSP,THSD4,TNS1,TOP2A,TRAF3,UBIAD1	AKT1,Akt,ESR1,ESR2,FOXO1,HIF1A,JUN,LEP,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,TP53,beta-estradiol,fatty acid,valproic acid	
P3	 	pirinixic acid	 	chemical toxicant	Activated	4.226	bias	0.440	0.804	2.58E-12	ABCC1,ABCC3,ACOT4,AKR1C3,ALAS1,ALDH3A2,ALDOC,ANXA2,ANXA7,APOE,ASNS,BSG,CCND3,CCT3,CCT7,CD63,CIDEA,CTSB,CXCL12,CYP27A1,CYP4A11,DAD1,DYNLL1,ELOVL1,FAS,FCER1G,FKBP1A,G0S2,GAPDH,GBE1,GLUL,GOT1,GRPEL1,GRPEL2,GSTM3,HADHB,HIF1A,HMGCS1,HMGN1,HMOX1,HOXA7,HSPD1,HSPE1,IL1RN,IRF8,JUNB,KPNA1,LEP,LPIN2,MMP9,NR1D1,NR1H3,PAICS,PCK2,PDCD5,PFKL,PLIN2,PLIN5,PLTP,POR,PSMA3,PSMA4,PSMA5,PSMB5,PSMB6,PSMB7,PSMD14,PSME1,PTPRC,RTN4,SAA1,SCD,SREBF1,TALDO1,TBCA,THRA,TSPO,TXN,UBE2K,UCP2,VCAM1	ATF6,CEBPA,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,THRB,TNF,oleic acid,pirinixic acid	
P3	 	UCP1	-2.798	transporter	Activated	3.825	 	0.213	2.515	2.63E-12	AARS,ALAS1,ARHGEF2,ASNS,ATF4,ATF5,BZW2,CDKN2AIPNL,CEBPG,CHCHD10,CLCN3,DDIT3,DKK3,EEF1A1,GARS,GDF15,GHITM,GOT1,HMBOX1,LEP,LRRC8D,MTHFD1L,MYH1,NUPR1,ODC1,OTUB2,PCK1,PCK2,PGD,PSAT1,SHMT2,SLC3A2,SRM,SYNM,TENM4,TRIB3,TXN2,UCP2,XPOT	CEBPB,CREBBP,NFkB (complex),RELA,STAT3,UCP1,cyclic AMP	
P3	 	IL3	-4.348	cytokine	Activated	2.812	bias	0.513	 	3.48E-12	ALOX5AP,ATF5,BCL2L1,BTG2,C1QA,CALR,CAPZB,CCND2,CCND3,CCT5,CD14,CD3G,CD53,CD63,CD83,CEBPG,CRAT,CSF1,CSF1R,DAD1,DDIT3,EEF1A1,EGR1,EIF3G,FAS,FCGR2A,FKBP3,FOS,GNA13,HK1,HLA-A,HSPA2,HSPA5,HSPA9,IMPDH2,ITGAV,JUNB,MLF2,NARS,ODC1,PFKL,PLCB2,PROX1,PSMA5,PSMB7,PSMC4,PSME1,RALA,RAN,RPL13,RPL4,RPS12,RPS16,RPS19,RPS3,RPS4Y1,SLC3A2,SNRPD2,SOCS3,SOD1,STT3A,TARS,TIAL1,TPSAB1/TPSB2,UCP2,VCAM1,YWHAG	CSF1R,CTNNB1,ERK1/2,IL3,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SPI1,STAT3	
P3	 	HTT	1.240	transcription regulator	Activated	2.779	 	0.147	2.195	4.45E-12	ADAMTS5,ALDOA,ALDOC,APP,ATP5G1,ATP5J2,BCAP31,BTG3,C1QTNF3,CA12,CBX5,CDH11,CDK2AP1,CEBPB,CLIC6,CNR1,COL16A1,COL6A1,COX4I1,CSF1R,CTGF,CTSD,CYC1,CYCS,DDIT3,DKK3,DPM2,DUSP6,EDNRB,EEF1A1,EGR1,EMC8,EPB41L3,FAM173A,FGF1,FHL1,FKBP4,FOS,GAPDH,GLUL,GPC1,GSS,HIF1A,HMGA1,HMGCS1,HRAS,HSP90AB1,HSPA5,HSPA8,HSPA9,HSPD1,HSPE1,IL11RA,JUNB,KCNK2,KLF4,LTF,MCAM,MDH2,MFAP4,MICU1,MLF2,MMP14,MPEG1,MT-CYB,MYH1,NAB2,NDUFA1,NDUFA11,NDUFA12,NDUFB4,NDUFS4,NFE2L2,NR2F1,NR4A1,PABPC4,PEA15,PFN1,PLOD3,POR,PPP1R16B,PPP1R1B,PRELP,PSMA5,PSMD3,PSME1,PTPN23,RAB10,RABIF,RPH3A,RPS29,SEPHS1,SERPINA1,SERPINH1,SFRP1,SIRPA,SLC25A22,SOD1,SPP1,SQSTM1,SRM,STRN4,STXBP1,TFRC,THRA,THRSP,TUBB,UCHL1,UQCR11,VAPA,VCAM1,YWHAG	APP,Akt,BDNF,CREB1,Creb,ELK1,HIF1A,HTT,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	CD3	 	complex	Inhibited	-4.591	bias	-0.479	-0.464	7.00E-12	AARS,ACTR3,AHCYL1,ALAS1,ANXA1,AP1B1,ATF4,BCL2L1,CALM1 (includes others),CCND2,CCND3,CD28,CD4,CD53,CD83,CDK2AP1,CDK6,CLIP1,COX5A,COX7A1,CYC1,CYCS,DAD1,EDIL3,FAS,FCER1G,FKBP1A,FKBP2,FKBP3,FOS,FTL,FYB,GAPDH,GBP1,GYS1,HAX1,HDAC2,HIF1A,HINT1,HMGN1,HS2ST1,HSPA5,HSPA8,HSPE1,ID4,IFRD2,IGFBP6,ILF2,IRF8,JUNB,KDM5D,LCP1,LONP1,MAF,MDH2,MMRN1,MSR1,MT-CO1,NAGA,NFE2L2,NME1,NPM1,NR4A1,OAZ1,ODC1,OGDH,PABPC4,PCYT2,PDCD5,PFN1,PGAM1,PHB,PHB2,PLEK,PLIN2,POLR2K,PRKACA,PSAP,PSMA5,PSMF1,PTP4A2,PTPRC,RAD23B,RBBP8,RPL30,RPS3A,S100A11,SHC1,SLC25A5,SLC5A3,SOCS3,SORL1,SRPRB,STIM1,TCEA1,TCF7,TFRC,THBS1,TOP2A,TXNRD1,UQCR11,VDAC2,XRCC6,YARS	Akt,CD3,ELK1,IL2,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,RNA polymerase II,SP1,STAT3,STAT5B,TCR	
P3	 	CEBPA	2.041	transcription regulator	Activated	2.142	 	0.237	0.328	1.09E-11	ADIPOQ,AKR1B1,AKR1C1/AKR1C2,AKR1C3,ALOX5AP,ANXA1,APOB,ARL4C,ARL6IP5,ASNS,ASS1,ATF4,BIN1,BTG2,C3AR1,CCND2,CD14,CD3G,CEBPB,CHI3L1,COX4I1,CREG1,CSF1,CSF1R,CTNNA1,CYCS,DDX21,DGAT2,EDF1,EPHX1,F8,FHL1,FOS,G0S2,GAPDH,GBP1,GSK3B,GSTP1,HMGA1,HMOX1,HSPA5,IGFBP3,IGFBP4,IL1RN,JUNB,LEP,LITAF,LTF,MAPKAPK2,MMRN1,MT-CO1,NR5A2,PAX5,PCK1,PGD,PLIN1,PLIN2,PLOD2,PLXND1,PPP1R3C,PTGFR,PTPRC,PTX3,SAA1,SCD,SEMA3E,SOCS3,SOD1,SPP1,SREBF1,TGFB2,THBS1,THRA,TNFRSF1A,TP63,TUBB2A,UBE2I	CEBPA,CEBPB,CTNNB1,ESR1,FOS,FOXO1,GATA1,IRF8,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RNA polymerase II,RUNX1,RXRA,SMARCA4,SP1,SPI1,STAT3,TP53	
P3	 	hydrogen peroxide	 	chemical - endogenous mammalian	Activated	4.383	bias	0.443	0.784	1.10E-11	ADAM17,ADAM9,ADIPOQ,AKR1C1/AKR1C2,ANXA2,APP,ATP6V1A,BCL2L1,BSG,BTG2,CCND3,CD63,CD68,CEBPG,CNR1,CSF1,CTGF,CTSB,CTSD,CTSS,CYCS,DDIT3,DUSP1,DUSP10,DUSP4,EEF1A1,EEF1B2,EGR1,FAS,FOS,FTH1,GDF15,GSTM3,HDAC2,HIF1A,HMOX1,HRAS,HSPA5,KIT,KLF2,KLF4,MCAM,MMP9,MPV17,MSMO1,MSR1,MT-CO1,NFE2L2,NR4A1,NUPR1,ODC1,OSGIN1,PFDN5,PRDX1,PSMC4,PTP4A2,PTX3,RAN,RPL21,RPL31,RPL7A,RTN3,SELENOH,SERPINH1,SHC1,SLC20A1,SLC30A1,SLC7A11,SOD1,SPP1,SREBF2,TFRC,TRIB3,TUBB2A,TXN,UCP2,UNG,UQCRH,VCAM1,XRCC6	CEBPA,ELK1,FOXO1,HIF1A,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT3,TNF,TP53,hydrogen peroxide,nitric oxide,reactive oxygen species	
P3	 	NFKBIA	-1.655	transcription regulator	 	0.452	 	0.191	-1.125	1.10E-11	ADAMTS5,ATP5J2,BCKDK,BCL2L1,BTG2,CCND2,CEBPB,CFTR,CHI3L1,COL5A2,CSF1,CTNNA1,CTSB,CXCL12,CYP1B1,DDIT3,DUSP6,EIF4G2,ERAP2,FAS,FOS,FSCN1,GAS5,GM2A,GRN,GSTM5,HIF1A,HLA-A,HMGA1,HMOX1,HOXA10,HOXB5,HSPA5,HSPA8,IGFBP6,IL1RN,IRAK1,ITGAV,JUNB,LIMA1,LITAF,LY6E,LYNX1,MMP14,MMP9,MPDU1,MSC,MT-CYB,NAGLU,NINJ1,NR4A1,NR6A1,PARK7,PCDH7,PDGFA,PEA15,PLAT,PLAU,PLD3,PTP4A2,PTX3,RABEP1,RPL8,RPS2,RPSA,SDC4,SERPINE2,SFRP1,SOCS3,SOD1,SORL1,SOX9,TACR1,TFRC,TGFB2,TMEM176B,TOLLIP,VCAM1,XRCC6	CEBPA,CHUK,CREBBP,CTNNB1,IKBKB,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,RELA,STAT3,TNF,TP53	
P3	 	forskolin	 	chemical toxicant	Activated	2.885	bias	0.343	-0.201	1.56E-11	ACTB,ACTN1,ADCYAP1,ADIPOQ,ALDOA,ALDOC,ALPL,APP,ARL4C,ARL6IP5,ATP6V0B,ATP6V0C,ATP6V0D1,ATP6V1A,ATP6V1B2,BAG3,BTG2,CALM1 (includes others),CALR,CCDC85B,CCND2,CCND3,CD14,CD4,CD68,CDK16,CEBPB,CFTR,CNP,COL15A1,CREBL2,CRISPLD2,CSF1,CTBP1,CTGF,CYP1B1,DAB2,DDIT3,DUSP1,EGR1,EIF5A,EMD,ESR2,FAS,FGFR2,FKBP5,FLNC,FOS,FOSB,FST,GAB2,GBP1,GEM,GRN,GSTM5,GSTP1,HIF1A,HMOX1,HSD11B2,IGFBP3,IGFBP6,JUNB,KLF4,LEP,LITAF,LTF,MAP2K3,MAP4K4,MAT2A,MMP9,MSMO1,NPY1R,NR4A1,ODC1,P4HA2,PCK1,PEG10,PLAT,PLAU,PPP1R3C,PPP2R1A,PRDX1,PRKACA,PSMD3,RAB20,RAB4A,RAB5C,RAB7A,RAPGEF3,RPL37A,RPL38,RPS10,RPS11,SERINC2,SHC1,SLC2A5,SLC7A11,SPP1,STARD7,THBS1,THRSP,TMBIM6,TPO,UCP2,USP18	CEBPA,CEBPB,CREB1,CTNNB1,FSH,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PGR,RELA,STAT3,TNF,forskolin,progesterone	
P3	 	ciprofloxacin	 	chemical drug	 	-1.111	 	0.013	-1.186	1.99E-11	ACO2,ACTN1,APP,ATP6V1A,ATP6V1B2,ATP6V1E1,CD68,CTSA,CTSD,EDIL3,GBA,GRN,HLA-A,HSPA9,HSPD1,LGMN,LONP1,MPEG1,MSR1,MTHFD1L,PSAP,RPL12,RPL7A,RRAGC,RUVBL1,SHMT2,SLC2A6,SPP1,SRPRA,STAB1,STXBP1,TTYH3,VDAC1	 	
P3	 	nitrofurantoin	 	chemical drug	Activated	3.131	 	0.090	2.547	2.66E-11	ABCB11,ACTB,ACTG1,ANXA2,ANXA5,APOE,ASNS,ASS1,BCL2L1,BTG2,CAPN2,CAPN6,CES1,CTSB,CTSS,CYP4A11,DDIT3,EEF1A1,FAS,GAS5,GSS,GSTM3,GSTP1,HMGCS1,HMOX1,HSPA5,IGFBP3,MMP14,NQO1,ODC1,PLAT,PRDX1,RPL13,RPL13A,RPS8,S100A11,SERPINA1,SPP1,TNFRSF12A,TUBB,TXN,VCAM1	 	
P3	 	BDNF	-1.496	growth factor	 	-0.736	bias	0.284	-2.641	5.06E-11	ADCYAP1,ANXA2,ANXA5,AP3D1,APP,BAG3,BCL2L1,CCND2,CNR1,CSPG4,CYGB,CYR61,DUSP1,DUSP4,DUSP6,EGR1,FAM49A,FLNA,FOS,FOSB,FSCN1,FTL,GLUL,GPC4,HSPA2,HSPA5,KIF1A,LEP,MACROD1,MAP1B,MAPT,MBP,MVD,MYO5A,NAB2,NCAM1,NCDN,NR4A1,P4HA1,PFKFB3,PLP1,PLTP,PPP1R1B,RNH1,RPL13,RPL37A,SEMA3E,SERPINH1,SFRP1,SFRP2,SORL1,SPP1,STRN4,STXBP1,TFRC,THRA,TMBIM6,TPP1,TRAF3,YWHAG	BDNF,CREB1,CREBBP,CREM,CTNNB1,Creb,ELK1,FAS,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,RNA polymerase II,STAT3,cocaine	
P3	 	LONP1	3.817	peptidase	 	-0.958	 	-0.203	-0.479	9.07E-11	ANXA2,ATP5D,C1QBP,COX5A,HIST1H2BC,HSPA9,HSPD1,HSPE1,IMMT,MDH2,MT-ATP6,MT-CO1,MT-CYB,MT-ND5,PFN1,PGAM1,S100A11,TPM3,UQCRFS1,VDAC1,VDAC2	 	
P3	 	IFNG	-4.570	cytokine	Activated	4.533	bias	0.318	0.661	9.67E-11	ACTB,ADIPOQ,ADRA2A,AGPAT1,AHCY,AIF1,ALOX5AP,APP,ARL6IP5,ASNS,ASS1,ATF4,BCL2L1,BMF,BMP6,C1QA,C1QB,C1QC,CCND2,CD14,CD209,CD4,CD63,CD83,CEBPB,CECR1,CFTR,CHAC1,CHST11,CNR1,COL5A2,CSE1L,CSF1,CSF1R,CTGF,CTSB,CTSD,CTSS,CXCL12,CXCL16,CYBB,CYP27A1,DDIT3,DEGS1,DUSP1,EDNRB,EEF1A1,EGLN3,EGR1,ERAP2,FAS,FCER1G,FCGR2A,FECH,FGF1,FKBP5,FOS,FOSB,FTH1,FTL,GBP1,GDF15,GJB2,GLUL,GNA13,GNG2,HIF1A,HLA-A,HLA-G,HMGA1,HMGCS1,HMOX1,HSP90AB1,HSPA8,HSPD1,IFI30,IGFBP4,IL10RA,IL1RN,IRAK1,IRF8,ITGAV,ITGB2,JUNB,KCNMA1,KLF2,KLF4,LEP,LGALS9,LY6E,MARCKSL1,MAT2A,MED15,METAP2,MMP9,MSR1,NCAM1,NFE2L1,NFKBIZ,NQO1,NR1D1,NR5A2,NUPR1,OAS1,ODC1,PANX1,PCK1,PDGFA,PEA15,PI4KB,PLAU,PLEK,POMP,PPIA,PPP1R1B,PRNP,PSMA4,PSMB10,PSME1,PSME3,PTGES2,PTPN23,RAB20,RAB38,RACK1,RAP2B,RARRES3,RBCK1,RRAGD,SCUBE1,SDC4,SEPT3,SERPINA1,SERPINH1,SFRP1,SHB,SLC4A2,SLC52A2,SLC6A6,SLC7A11,SLC7A5,SLFN5,SOCS3,SPP1,SQSTM1,SREBF1,SREBF2,SYNM,TACR1,TFRC,TGFB2,THBS1,THEMIS2,TMOD1,TNFRSF12A,TNFRSF1A,TP63,TPO,TREM2,TYMP,TYROBP,UBE2E1,UNC5B,USP18,VCAM1,WARS,XIST,ZBTB16,ZPR1	CEBPA,CEBPB,CTNNB1,FOXO1,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF	
P3	 	interferon beta-1a	 	biologic drug	 	 	 	 	 	1.23E-10	ANAPC11,ATP5I,ATP5L,CCT4,CD4,COX5A,CSF1R,EEF1G,ENO1,FCER1G,FKBP1A,FYB,GPR65,GSTP1,IL1RN,LTF,MMP9,NDUFA1,NDUFA2,NDUFB9,PFDN5,PGAM1,PPIA,PSME1,RAN,RPL18,RPL19,RPL24,RPL26,RPS19,SERPINA1,SLC25A6,TTC1,UQCRFS1	 	
P3	 	INSR	1.601	kinase	Activated	4.406	bias	0.478	1.572	1.31E-10	ACO2,ARHGDIA,ARHGEF2,ATP5D,ATP5G1,ATP5H,ATP5J2,ATP5L,C1QA,CCND2,CD83,CFL1,COX4I1,CRAT,CSTB,CTGF,CTSB,CYC1,CYCS,CYP1B1,DES,DUSP1,EGR1,FH,FHL1,FLNC,FOS,GANAB,GAPDH,GNB1,GRN,HADHB,HMGCS1,HSPD1,JUNB,KIT,LCP1,LEP,LYZ,MARCKSL1,MDH2,MMP9,MPEG1,MSMO1,MT-CO1,MVD,NDN,NDUFA1,NDUFA4,NDUFB4,NDUFB9,NFE2L2,NR1H3,OGDH,PHLDA2,RAB7A,RPL7A,RPS16,SLC20A1,SLC30A1,SOCS3,SREBF2,THRA,TNFRSF1A,UCP2,UQCRC1,VCAM1	ADIPOQ,Akt,CEBPA,CEBPB,D-glucose,FOXO1,HIF1A,IGF1R,INSR,Ins1,JUN,MYC,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,estrogen receptor	
P3	 	PPARGC1A	1.599	transcription regulator	Activated	2.645	bias	0.555	 	1.72E-10	ABCB11,ADIPOQ,AK1,ALAS1,ATP5H,ATP5J2,CALM1 (includes others),CD68,CDC42EP1,CEBPB,CIDEA,COX4I1,COX5A,COX7B,CYCS,GSK3B,IL1RN,LIPA,MBP,MDH2,ME1,MT-CO1,MYH1,NDUFS8,NPC1L1,NR1H3,NR5A2,PCK1,PCK2,PGAM1,PHYH,PLIN2,PLIN5,PRDX5,SCD,SCO2,SESN2,SOCS3,SOD1,SREBF1,SYT2,THRA,TNFRSF12A,TRIB3,TXN2,UCP2,UQCRFS1,UQCRH	CEBPA,CEBPB,FOXO1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,THRB,fatty acid,palmitic acid	
P3	 	PRKAG3	-6.534	other	 	 	 	 	 	3.85E-10	ALAS1,ATP6V1A,BTG2,CES1,CLCN3,CTNNA1,CYP27A1,DUSP10,EGR1,EIF4E2,FTL,GAS5,GBE1,GID4,GOT1,HN1,HSPA5,IFI30,JUNB,KLF2,KLF4,LEP,LMCD1,MAT2A,MID1IP1,NEO1,ODC1,PHLDA3,PPP1R14B,RPE,RPL12,RPL13A,SLC7A2,SNCG,SOX17,SREBF1,TFRC,THRSP,TPPP3,TRIM16	 	
P3	 	lactacystin	 	chemical - protease inhibitor	Activated	2.303	bias	0.280	0.515	4.22E-10	ACTB,AKR1B1,AKR1C1/AKR1C2,APOB,APP,ASNS,BAG3,CCND2,CCND3,CFL1,CTSD,DDIT3,DUSP1,EBNA1BP2,EIF5A,FAS,FTL,GSTP1,HIF1A,HLA-A,HMOX1,HSPA5,HSPB8,MAP1B,MMP9,NFE2L2,NR1H3,NR4A1,P4HA2,PEA15,PEBP1,PFN1,PPIA,PRKCE,RABIF,RPLP0,SLC3A2,SQSTM1,SREBF1,SREBF2,TMSB4Y,TUBB2A,TXN,TXNRD1	AKT1,Akt,CTNNB1,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SP1,STAT3,TP53,lactacystin	
P3	 	arsenite	 	chemical toxicant	 	0.681	bias	0.281	-0.226	7.74E-10	ABCC1,ADAM12,ARL6IP5,ATF4,COL8A1,CYP1B1,DUSP1,EGR1,FOS,FST,GCLM,GPC1,GSTP1,HDAC2,HMOX1,HSPA9,KLF2,MAFG,NFE2L2,NQO1,NR4A1,PPP1R3C,PTGES2,RNH1,SGCD,SQSTM1,TACR1,TGFB2,THBS1,TXNRD1	AKT1,CTNNB1,ERK,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SHC1,SP1,STAT3,TP53,arsenite	
P3	 	benzo(a)pyrene	 	chemical toxicant	Activated	2.480	bias	0.319	0.801	1.24E-09	ABHD4,ADAM12,ANXA1,ARHGDIA,ARL6IP5,BTG3,CDK2AP2,CEBPG,COL8A1,COMT,CYP1B1,CYR61,DOK5,ENTPD5,EPHX1,FOS,FST,GCLM,GPC1,GSTP1,HDAC2,HMOX1,HRAS,IGFBP6,KLF2,LCP1,MAF,MAFG,MAP2K3,ME1,NQO1,NR4A1,PGD,PPIF,PPP1R3C,PRKACA,SERPINA1,SGCD,SLC1A4,SQSTM1,TACR1,TAF6,TGFB2,THBS1,TKT,TP63,TXNRD1	AHR,CREBBP,EGF,EP300,ERK,ESR1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,benzo(a)pyrene	
P3	 	IND S1	 	chemical - kinase inhibitor	 	-0.277	 	-0.065	-0.045	1.78E-09	ACTB,ATP5D,C1QBP,CFL1,COPS8,COX5A,ENO1,FH,PGAM1,PRDX1,STIP1,TUBB,VDAC2	 	
P3	 	HRAS	2.528	enzyme	 	1.926	 	0.240	0.430	2.11E-09	ACTB,ACTG1,ADRA2A,ANXA2,APP,ARF1,ARF6,ASNS,BCL2L1,BTG2,C1QC,CAPG,CAPN2,CCND2,CCND3,CDON,CEBPB,CHST11,COL5A2,CSF1,CSTA,CTGF,CTSB,CTSS,CXCL12,DDIT3,DUSP1,DUSP6,EGR1,EIF4E2,EPHX1,ERP29,FAS,FBXW11,FHL1,FLNA,FOS,FOSB,FSTL3,GJB2,GNA13,GRN,HIF1A,HMOX1,HRAS,HSPA8,IFI30,IGFBP4,ITGAV,JUNB,LASP1,LYZ,MCAM,MMP14,MMP9,MSMO1,MTHFD1L,MYL12A,MYL9,NEXN,NID2,NQO1,PCK1,PDGFA,PFN1,PLAU,PLOD2,PLTP,PRNP,RPL30,RPL37,RPLP1,RPS10,RPS3,RTN4,SERPINE2,SESN3,SIRPA,SOD1,SORBS1,SPP1,SREBF1,TGFB2,THBS1,TMSB10/TMSB4X,TOP2A,TPO,TYMP,WSB2	AKT1,CEBPB,CREBBP,CTNNB1,ELK1,ESR1,FOXO1,HRAS,MYC,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	ERBB2	1.144	kinase	 	1.558	bias	0.337	-0.922	2.19E-09	ACTB,ADAM12,ADAM17,ADAMTS5,ALAS1,ALDOC,ANXA2,APLP2,ATF4,ATP6V1A,BCL2L1,BTG2,CCND2,CCND3,CDH11,CDK6,CDON,CEBPB,CES1,CHCHD10,CHST2,COL5A2,COL6A1,CSF1R,CTGF,CTSB,CXCL12,CYP4B1,DDIT3,DERL1,DUSP6,EGR1,EIF6,EMP1,EPSTI1,ERBB4,ESR2,ETV5,FOS,FSCN1,FSTL3,GBE1,GPAA1,GPC1,GSK3B,HADHB,HIF1A,HNRNPK,HSPB8,IGFBP3,IGFBP4,IGFBP6,JUNB,KIFC3,KIT,KLF4,LAMP2,LITAF,MAP1B,MAP2K3,MGAT5,MKI67,MKNK2,MMP14,MMP9,MYL9,NNMT,NR1H3,NRBP1,NUCB2,P4HA2,PCK2,PFKFB3,PHLDA2,PHYH,PLAT,PLAU,PSMD8,PTPRK,RAD51C,RHOD,RPL17,RPS10,SEC61A1,SFRP1,SIRPA,SLC4A7,SORBS1,SRPX,ST3GAL6,TAX1BP3,THBS1,TMEM43,TOP2A,UQCR10,WNT5B,WSB2	CTNNB1,EGF,EGFR,ERBB2,ERBB4,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	tosedostat	 	chemical drug	Activated	3.843	bias	0.663	 	2.28E-09	ASNS,ASS1,ATF5,CARS,CEBPB,CHAC1,DDIT3,MARS,PSAT1,SARS,SESN2,SLC7A11,STC2,TRIB3,WARS	 	
P3	 	JUN	-2.817	transcription regulator	Activated	3.534	bias	0.354	1.357	2.47E-09	ALAS1,ANXA1,ANXA2,APOE,APP,ASNS,C3AR1,CAPN2,CAPNS1,CCND2,CCND3,CD14,CD68,CLDN2,COMT,CSF1,CSF1R,CSTA,CTGF,CXCL16,CYCS,CYGB,CYP1B1,DUSP1,EIF4A1,FAS,FLNC,FOLR2,FOS,FTH1,GOT1,GSK3B,GSTP1,HLA-G,HMGA1,HMOX1,IGFBP3,IGFBP4,ITGAV,JUNB,LAMP2,LPAR1,MAT2A,MBP,MMP9,MSR1,MVD,NCAM1,NFKBIZ,NQO1,NR5A2,PEA15,PLAU,PRDX1,PRKCE,PTX3,SAA1,SCD,SDK1,SLC6A6,SLC7A1,SNCG,SOCS3,SPP1,STIM1,THBS1,TXN,VCAM1,XPO5,XYLT1,YWHAG	CEBPA,CEBPB,ETS1,FOS,IGF1,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TNF	
P3	 	FSH	 	complex	 	0.245	bias	0.255	-1.139	3.43E-09	ACP2,ACTB,ACTN1,ADAM17,ADCYAP1,ALDH3A2,ALPL,ARHGAP35,ARL4C,ARL6IP5,ARPC4,BCKDK,BTG2,CCND2,CDK16,CDK6,CITED1,CLIP1,COL15A1,CREBL2,CRYM,CTGF,DAB2,DUSP1,DUSP3,ESR2,FKBP5,FLNC,FOS,FOSB,FST,GBP1,GDE1,GEM,GNB1,GOT1,ID4,IGFBP3,IGFBP4,IL1RN,JUNB,KIF5B,MAP2K3,MAP4K4,MMP9,MSMO1,NEO1,NLK,NPY1R,NR4A1,P4HA2,PCK1,PKM,PLAT,PPP1R2,PPP2R1A,PRNP,PSMD3,RAB1A,RAB4A,RAB5C,SMARCA4,STIP1,TFRC,TGFB2,THBS1,TMBIM6	CEBPB,CREBBP,Cg,ERK,ERK1/2,FSH,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,STAT3,TP53,cyclic AMP,progesterone	
P3	 	F2	1.376	peptidase	Activated	2.426	bias	0.641	 	3.81E-09	AKR1B1,ALDH1B1,B3GNT5,CALR,CCND2,CD63,CD68,CDC42EP1,CTGF,CTPS1,CYBB,CYR61,DHRS9,DKK3,DOK5,DUSP1,EDNRB,EGR1,EIF4A1,ERP29,F2RL3,FHL1,FOS,FOSB,GNA13,HIF1A,HMGA1,HMOX1,IFRD2,IGFBP4,JUNB,LAMP2,MMP9,PDGFA,PLAT,PPIF,PRKCE,RNH1,SDC4,SLC12A7,SLC2A6,SLC7A1,SRM,TFPI,TGFB2,THBS1,TNFRSF12A,TRAF3,VCAM1,YIF1A	ERK1/2,F2,F2R,FGF2,FOXO3,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TGFB1,TP53	
P3	 	PPARA	1.151	ligand-dependent nuclear receptor	 	0.079	 	0.222	-1.515	4.78E-09	ADIPOQ,AHCY,ALDH3A2,ANXA2,APOE,APP,ARHGDIA,ASNS,ASS1,BCKDK,C1QA,C1QB,C6,CD63,CEBPB,CIDEA,COX4I1,CXCL12,CYB5B,CYBB,CYP27A1,CYP4A11,DYNLL1,FOS,G0S2,GLUL,GSTM3,GSTP1,H2AFZ,HADHB,HIF1A,HMGCS1,HMGN1,HMOX1,IGFBP3,IGFBP6,IL1RN,MAT2A,ME2,MKI67,MMP9,MSMO1,MVD,NFE2L2,NPC1L1,NR1D1,NR1H3,PCK1,PLIN1,PLIN2,PLIN5,PLTP,PMVK,POR,RTN4,SAA1,SCD,SERINC2,SREBF1,SREBF2,SRM,STIM1,TALDO1,TOP2A,TPP1,TSPO,TXN,UCP2,UQCRC1,VCAM1	ATF6,CEBPA,CEBPB,FOXO1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,THRB,fenofibrate,oleic acid,pirinixic acid	
P3	 	PD98059	 	chemical - kinase inhibitor	Inhibited	-4.965	bias	-0.440	-1.044	5.56E-09	ACTR3,ADIPOQ,ALDOA,ANXA1,ATF4,BCL2L1,CCND2,CD14,CD4,CD83,CDC42EP1,CEBPB,CTGF,CTSB,CYCS,CYP1B1,DDIT3,DES,DUSP1,DUSP4,DUSP6,EDNRB,EEF1A1,EGR1,EIF5,EMP1,ENO1,FKBP5,FOS,FOSB,FTH1,GFPT1,GRN,GSK3B,HADHB,HIF1A,HMOX1,HNRNPAB,HSD11B2,HSPA5,HYOU1,IGFBP3,IL1RN,ITGAV,ITGB2,JUNB,LAMP2,LEP,MAPKAPK2,MAT2A,MKI67,MMP14,MMP9,MSR1,MT1M,MYH1,NINJ1,NQO1,NR4A1,PCK1,PDGFA,PFKFB1,PHLDA2,PLAT,PLAU,RAB20,RAN,RPS2,SERPINA1,SIGMAR1,SIRPA,SLC3A2,SNRPD1,SOCS3,SOD1,SPP1,SREBF1,ST6GALNAC2,THBS1,TOP2A,TUBB2A,TXN,TYMP,VAPA,VCAM1	CEBPA,ERK1/2,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RAF1,RELA,STAT3,TNF	
P3	 	XBP1	1.173	transcription regulator	Activated	5.012	bias	0.611	 	7.11E-09	APP,CALR,COPB1,COPE,COPG1,DAD1,DDIT3,DERL1,DNAJC1,EDEM1,ERP29,FAS,FKBP14,FKBP2,GCC1,GORASP2,HMOX1,HSPA13,HSPA5,HYOU1,KLF4,NR1H3,NUCB2,PDIA6,PHLDA2,PPIB,PRNP,RCN3,RPN1,RPN2,SEC23B,SEC61A1,SEC61G,SERPINA1,SOD1,SREBF1,SRPRA,SRPRB,SSR4,TXN,VCAM1,XRCC6,YIF1A	ATF4,ATF6,BACH1,CTNNB1,DDIT3,E2F1,FOS,FOXO1,Immunoglobulin,Jnk,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SIRT1,STAT3,TP53,XBP1	
P3	 	curcumin	 	chemical drug	 	-0.352	bias	-0.272	1.650	7.50E-09	ABCC1,ADAM17,ADAMTS5,ADIPOQ,APOE,APP,ATOX1,BCL2L1,CCND2,CCND3,CDK6,CEBPB,COX7B,CTGF,CTNNA1,DDIT3,EGR1,ENTPD5,FAS,FASTK,FOS,FOSB,FTH1,FTL,GABBR1,GCLM,GLUL,GSK3B,GSTP1,HDAC2,HIF1A,HMOX1,HSPA8,IGFBP4,JUNB,LEP,MAPT,MARCKSL1,MLF2,MLH1,MMP14,MMP9,NCAM1,NEO1,NFE2L2,NQO1,OGDH,PLAU,SOCS3,SOD1,SOX9,SREBF1,SREBF2,TCEB2,TESK1,TFRC,TNFRSF1A,TOP2A,UCP2,VCAM1,YPEL1	CEBPA,ELK1,IL1B,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF,curcumin,nitric oxide	
P3	 	KITLG	1.515	growth factor	 	1.690	bias	0.574	 	7.97E-09	ACTB,AIF1,ALOX5AP,ATP6V1B2,BCL2L1,BZW2,CCND3,CD14,CD3G,CD68,CMA1,CREG1,CSF1,CTGF,EDNRB,EEF1A1,EGR1,ETF1,FOS,FTH1,HMOX1,IGFBP3,IL1RN,ITGAV,KIT,LAPTM5,LTF,LY6E,MID1IP1,NPM1,PKM,PRKCE,PSMB5,RAB4A,RCC2,RPLP0,SDHC,SHC1,STIM1,TACR1,TNFRSF1A,TPSAB1/TPSB2,TXNL1,UCP2,UGCG,WDR1	HIF1A,IL6,IRF8,JUN,KITLG,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,Ras,SP1,SPI1,STAT3,TP53	
P3	 	LDL	 	complex	Activated	2.458	bias	0.361	0.383	8.52E-09	APOE,BCL2L1,CAPN2,CD68,CTGF,CYBB,DDIT3,DUSP1,EDNRB,EGR1,FOS,FOSB,G0S2,GCLM,HIF1A,HMOX1,HSPA5,HYOU1,IGFBP3,IGFBP4,IL10RA,IL1RN,ITGAV,LASP1,LIMS1,MKI67,MLH1,MMP14,MMP9,MSC,MSR1,NLK,NME1,NR1H3,NR4A1,PANX1,PLAT,PLAU,PLIN2,RABEP1,SHC1,SOCS3,SREBF1,SREBF2,TNFAIP8L2,UBE2K,VCAM1	CEBPA,CTNNB1,FOS,IL1B,Jnk,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,lipopolysaccharide	
P3	 	PRL	-16.150	cytokine	Activated	3.225	bias	0.466	0.012	1.16E-08	ACTB,ACTR3,AKR1C3,ANXA2,ANXA5,APP,ATP5H,CAPN2,CCND3,CLDN5,COX4I1,CTSA,CTSB,CTSD,CTSS,DES,DNAJA4,DVL1,EGR1,ENO1,EPSTI1,ERBB4,ESR2,FOS,GNA12,HSD11B2,HSPD1,IGFBP3,LY6E,MAFG,MARS,MMP14,NUPR1,OAS1,ODC1,PLAT,PROX1,PSME1,PTGFR,RHOG,RPSA,SFRP2,SOCS3,SOD1,SPP1,TECR,TP63,TPM3,TUBA1B,USP18,YWHAG	CEBPA,CEBPB,Creb,ERK1/2,FOS,GATA1,GNRH1,IGF1,Ins1,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PRL,RELA,SP1,SREBF1,STAT3,STAT5B	
P3	 	gentamicin	 	chemical drug	Activated	2.585	 	0.175	1.384	1.19E-08	ACSL3,ALCAM,ALPL,ARF6,ATIC,BTG2,BTG3,CALR,CEBPB,CPEB1,CTSD,DDIT3,EAF1,EEF1A1,EGR1,FMO1,GAS5,GDF15,GJB2,GNL3,GSTM5,GUK1,HMOX1,HSD11B2,HSPA5,HYOU1,IGFBP3,JUNB,LITAF,MAF,NME1,NPM1,NR1D1,PLIN2,PSAT1,RPS27L,RUVBL1,S100A1,SPP1,SQSTM1,ST6GALNAC3,TANGO2,TARS,TFRC,TUBB,UBQLN1,VAT1,VCAM1	NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,gentamicin	
P3	 	mifepristone	 	chemical drug	 	0.929	 	-0.138	1.922	1.21E-08	ABCB11,ABCC3,ALAS1,ALPL,ANXA1,APOE,BCAT1,BCL2L1,C1QB,CD14,CEBPB,CFTR,CHI3L1,COL15A1,COL5A2,CTGF,CTNNA1,CTSD,CYBB,DKK3,DUSP1,EDNRB,EGR1,EPHB3,FAS,FKBP5,FOS,FST,FTH1,HOXA10,HSPA4,HSPA5,IGFBP3,JUNB,KIT,KLF4,LAMA2,LTF,MMP9,NDN,NFE2L2,NME2,NPL,NPY1R,NR4A1,PFKFB3,PLAT,REM1,SFRP2,SOX17,SPP1,SRM,TFPI	CEBPA,CEBPB,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PGR,RELA,STAT3,TNF,TP53,dexamethasone,mifepristone,progesterone	
P3	 	PPARG	1.337	ligand-dependent nuclear receptor	 	0.345	 	0.230	-1.291	1.37E-08	ADIPOQ,ALDH1A2,APOE,APP,BIN1,CCPG1,CDK6,CEBPB,CES1,CIDEA,CRAT,CTGF,CTPS1,CXCL14,CYP4A11,CYP4B1,DGAT2,EGLN3,EPHX1,FGF1,FST,GAPDH,GDF15,HADHB,HMOX1,HYOU1,IGFBP3,IGFBP6,IVD,KLF4,LEP,ME1,MKI67,MKNK2,MMP14,MMP9,NFE2L2,NR1D1,NR1H3,NR4A1,ODC1,PCK1,PCK2,PCLO,PEA15,PFKFB3,PLIN1,PLIN2,PLIN5,RAB20,RGL1,RPSA,SAA1,SCD,SERPINA1,SLC27A3,SLC9A1,SNCG,SOCS3,SOD1,SORBS1,SPP1,SREBF1,STIM1,STXBP5,TKT,TRIB3,TUBB,UCP2,VAMP5,VCAM1,XYLT1,YWHAG	ATF6,CEBPA,CEBPB,CREB1,CREBBP,Ins1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,oleic acid,rosiglitazone,troglitazone	
P3	 	MEL S3	 	chemical - kinase inhibitor	 	-1.604	bias	-0.269	-0.596	1.41E-08	ACTB,ATP5D,C1QBP,COPS8,COX5A,EGR1,ENO1,ERP29,FH,PCK2,PGAM1,STIP1,TUBB,VDAC2	 	
P3	 	MTOR	1.541	kinase	 	1.056	 	0.144	0.183	1.46E-08	AKR1B1,ARL4C,BCL2L1,CEBPB,CLTC,CNP,COX4I1,DDIT3,ENO1,EPRS,FKBP1A,GSTM5,HADHB,HIF1A,HSP90AB1,IRAK1,LEP,MAPT,MBP,MDH2,MMP9,MT-CO1,MT-TY,NAB2,NCAM1,OAS1,PFN1,PGP,PHLPP1,PKM,PLP1,PPIB,PRDX5,PSMB5,PYGB,RAB4A,RAP1GDS1,RPL12,RPL32,RPS11,SERPINA1,SNCG,SOCS3,SOD1,SQSTM1,SRPX,TCEB2,TNFRSF1A,TXNL1,VCAM1	Akt,CEBPA,CEBPB,CTNNB1,FOXO1,JUN,MTOR,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TNF,sirolimus	
P3	 	PDGF BB	 	complex	 	0.666	bias	0.424	-2.123	1.56E-08	AKR7A2,BMP6,CALM1 (includes others),CBX4,CCND3,CEBPB,CSF1,CSF1R,CTGF,CYCS,CYR61,DAB2,DDIT3,DUSP1,DUSP6,EDNRB,EGR1,EIF4E2,FHL1,FLNA,FMO1,FOS,FOSB,GDF15,GEM,GLUL,GSS,HMGCS1,HMOX1,HRAS,IGFBP4,JUNB,MAT2A,MMP14,MMP9,MYH1,NEXN,NR4A1,ODC1,PDGFA,PLAT,PLAU,RACK1,RPL13,RPN2,SCD,SLC25A11,SLC6A6,SLC7A1,SOCS3,SREBF1,THBS1,TNFRSF12A,TRIB3,TRIOBP,UNC5B,VCAM1	CTNNB1,FGF2,FOS,FOXO3,HIF1A,JUN,Jnk,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PDGF BB,PPARA,RELA,SP1,STAT3,TGFB1,TP53	
P3	 	RET	5.543	kinase	 	1.378	bias	0.463	-0.723	1.74E-08	ANXA1,ATF4,CD151,CLDN5,CSF1,CTSB,CXCL12,DUSP6,EDNRB,EGR1,FKBP4,FOS,HSPA8,HSPA9,HSPD1,HSPH1,MAF,MAPKAPK2,MMP14,MMP9,PLAU,PLOD2,PRNP,RET,RTN4,SCARA3,SDK1,STIP1,STUB1	CEBPB,CTNNB1,FOXO1,HRAS,IKBKB,MMP9,NFKB1,NFKBIA,NFkB (complex),RELA,RET,SP1,STAT3,TP53	
P3	 	FN1	-1.134	enzyme	 	1.658	bias	0.398	-0.683	1.87E-08	AHCY,APLP2,APOE,APP,BCAT1,CAPN2,CCNI,CCT4,CD83,CDK6,CEBPB,CTBP1,CTSD,DLGAP4,EIF5A,FLNA,FOS,HK1,ITGAV,LIMS1,MAT2A,MMP14,MMP9,PLAU,PREB,RRAGD,SCRN1,SDC4,SDCBP,SDHC,SEC23B,SLC9A1,SMARCA4,SOCS3,SOX9,SPP1,SQSTM1,SURF1,THBS1,TOMM22,VDAC1,VPS4A	CEBPB,CREBBP,CSF2,CTNNB1,ELK1,ESR1,FN1,IL1B,Integrin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TP53	
P3	 	INS	-2.231	other	 	1.384	 	0.077	0.985	2.09E-08	ADCYAP1R1,ALDH3A2,BCL2L1,CEBPB,CIDEA,COX4I1,CTGF,DDIT3,EGR1,FADS3,FAS,FOS,FOSB,HIF1A,HSPA5,IGFBP3,IGFBP4,JUNB,LEP,NR1H3,OGT,PCK1,PLIN2,RASL12,SCD,SDHC,SMPD2,SOD1,SREBF1,SREBF2,TRIB3	AKT1,ATF4,CEBPA,CTNNB1,E2F1,FOXO1,FOXO3,HMGA1,IGF1,INS,IRS1,Insulin,JUN,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SIRT1,SP1,SREBF1,STAT3,TP53	
P3	 	IGF1R	1.211	transmembrane receptor	Activated	2.630	bias	0.428	0.207	2.32E-08	APP,ATP5D,ATP5G1,ATP5H,ATP5J2,ATP5L,BCL2L1,CD300C,CD53,CD68,CDC42,CEBPB,COX4I1,CTSD,CYCS,DDIT3,DES,FLNC,FOS,HIF1A,HSPA5,IGFBP3,IGFBP4,NDN,NDUFA1,NDUFA4,NDUFB4,NDUFB9,NR4A1,PHLDA2,PLAT,PLAU,SCARA5,SNCG,SREBF1,TPO,UQCRC1	CEBPA,CEBPB,CREB1,CTNNB1,EGFR,ELK1,FOS,IGF1R,INSR,Ins1,Insulin,Jnk,MYC,NFkB (complex),PDX1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,estrogen receptor	
P3	 	progesterone	 	chemical - endogenous mammalian	Activated	2.603	 	0.217	0.891	2.61E-08	ACTB,ADCYAP1,ADCYAP1R1,ADIPOQ,ADRA2A,AKR1C3,ALDH1A2,ALPL,APOE,ATP6V1B2,BCAT1,BCL2L1,BSG,C9orf72,CA12,CCND3,CDH11,CEBPB,CES1,CFTR,CLDN5,CNDP2,CNR1,COL15A1,COMT,CSF1,CXCL12,CYP1B1,DDIT3,EGR1,ESR2,FAM49A,FGFR2,FKBP3,FKBP4,FKBP5,FOS,FST,FTH1,GARS,GJB2,GRINA,HIF1A,HLA-G,HOXA10,HSD11B2,HSPA2,HSPA8,IGFBP3,KCNG1,LAMA2,LITAF,LOC284023,LTF,MAP2K3,MBP,ME1,MMP9,MYO1D,NCAM1,NME2,NOP16,NPL,NPY1R,NR1H3,NR4A1,PCK1,PDGFA,PFKFB3,PKM,PNKD,PRNP,PTX3,REM1,RTN4,SCD,SLC1A5,SPP1,SREBF1,TACR1,TGFB2,THRSP,TNFRSF1A,TNXB,TYMP,UGCG,WNT5B,YWHAG	ERK1/2,IL1B,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,progesterone	
P3	 	IPMK	-1.048	kinase	 	0.962	bias	0.710	 	2.64E-08	ABHD12,ACTB,CAPNS1,CYR61,FLNA,FLNC,FOS,FOSB,HSP90AB1,JUNB,MYL9,PFN1	ETS1,FOS,IPMK,JUN,NFE2L2,NFkB (complex),RELA	
P3	 	Cg	 	complex	Activated	2.424	bias	0.476	-1.025	2.88E-08	ACTB,ADCYAP1,ADCYAP1R1,AKR1C3,BCAT1,BCL2L1,BTG2,BTG3,CCND2,CEBPB,DUSP1,DUSP6,EGR1,EMP1,ESR2,FAS,FHL1,FST,G0S2,GJB2,GM2A,GPC1,HIF1A,HLA-A,HMGA1,HSD11B2,IGFBP3,IGFBP4,ITGAV,KLF4,LIMCH1,MAF,MAPKAPK2,MCAM,MMP9,MRPS6,MTPN,NR2F1,NR2F6,NR4A1,NR5A2,NUCB2,PFKFB3,PLAT,PLAU,PLXND1,PTGFR,PTX3,SCUBE1,SDC4,SEMA3E,SLC20A1,SLC4A4,SLC52A2,SPP1,SREBF1,TENM4,TGFB2,TNFRSF12A,UNG	CEBPB,Cg,ERK1/2,ESR1,ESR2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,STAT3,TP53,beta-estradiol,progesterone	
P3	 	EGF	-3.745	growth factor	Activated	2.980	bias	0.434	-0.364	2.88E-08	ACTN1,ADAM17,ALCAM,ARF6,ARHGEF2,BCL2L1,BTG2,CCND2,CCND3,CDC42EP1,CDH11,CEBPB,CLCN3,CLDN2,CSF1R,CTGF,CTSD,CXCL14,CYR61,DAD1,DDIT3,DUSP1,DUSP4,DUSP6,EEF1A1,EGR1,ENAH,ESR2,FOS,FOSB,FST,GAB2,GFPT1,GPS2,GSK3B,GSTP1,HIF1A,HMGCS1,HMOX1,HNRNPK,HOXB5,HRAS,IGFBP3,IGFBP4,JUNB,LPCAT3,LSM1,LTF,MMP9,NCAM1,NR4A1,ODC1,PFKFB1,PHLDA2,PLAT,PLAU,PPIB,PSMB5,PSMB6,PSMB7,RALA,S100A11,SCD,SERPINA1,SH2B3,SHC1,SLC4A7,SOCS3,SPP1,SPRY4,SREBF1,THBS1,TNFRSF12A,TP63,VCAM1,XRCC6	CTNNB1,EGF,EGFR,ERK1/2,ESR1,ESR2,HIF1A,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TGFB1,beta-estradiol,estrogen receptor	
P3	 	NRG1	-2.056	growth factor	 	1.492	bias	0.316	0.034	2.90E-08	ACTN1,ARHGEF2,ARPC4,ATF4,BIN1,CCND2,CCND3,CDC42EP1,CTGF,CYR61,DAD1,DDIT3,DUSP1,DUSP4,DUSP6,EEF1A1,EGR1,ESR2,FGF1,FOS,FOSB,GPS2,HIF1A,HMGA1,HMOX1,HNRNPK,IMMT,ITGAV,JUNB,LMO4,LPCAT3,LSM1,MBP,MMP9,MSR1,NR4A1,PCCB,PDGFA,PFKFB1,PLAU,PRKACA,SGSH,SLC4A7,XRCC6	EGF,ERK,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),NRG1,Pkc(s),RELA,SP1,STAT3,TP53	
P3	 	glutamine	 	chemical - endogenous mammalian	Inhibited	-2.261	 	-0.152	-1.683	2.91E-08	AARS,ACTB,AKR1C1/AKR1C2,ASNS,ASS1,ATF4,ATF5,BCAT1,BSG,CARS,CEBPB,DDIT3,DUSP1,FOS,HK1,HSPA5,JUNB,NR4A1,OAZ1,PCK1,PCK2,PHB,SLC16A1,WARS	ATF4,DDIT3,FOXO1,FOXO3,INS,Insulin,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,glutamine	
P3	 	cholesterol	 	chemical - endogenous mammalian	 	1.207	 	0.206	-0.029	2.92E-08	ABCB11,APOB,APOE,APP,ATF4,BSG,C1QC,CD14,CD68,CYB5B,CYP27A1,DDIT3,DES,EPHX1,GBA,HMGCS1,HSPA5,IL10RA,IL1RN,LAPTM5,LYZ,MAPT,ME1,MMP14,MPEG1,MSMO1,NPC1L1,NR1H3,NR4A1,PCYT2,PLTP,PMVK,PSAT1,SAA1,SCD,SLC7A5,SOCS3,SREBF1,SREBF2,THBS1,TMEM123,VCAM1	APOE,CTNNB1,IL1B,INSIG1,LDL,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARGC1A,RELA,SP1,SREBF1,SREBF2,STAT3,cholesterol	
P3	 	arsenic trioxide	 	chemical drug	Activated	2.328	 	0.153	1.492	3.25E-08	ALOX5AP,BCL2L1,CDK6,DDIT3,FAS,FTH1,GCLM,GLRX2,HIF1A,HMGCS1,HMOX1,HSPA5,KEAP1,MAF,ME1,MMP9,MSMO1,NFE2L2,NQO1,NQO2,PFKFB1,PIR,PTPRC,SCD,SHMT2,SLC7A11,SREBF1,SREBF2,TFRC,TP63,TXNRD1,VDAC1	BACH1,FOXO1,HIF1A,JUN,KEAP1,NFE2L2,NFKB1,NFkB (complex),NR4A1,PML,Pkc(s),RELA,SP1,STAT3,TP53,arsenic trioxide,hydrogen peroxide,reactive oxygen species	
P3	 	FLT1	-1.102	kinase	 	-0.853	 	0.243	-1.995	3.61E-08	AHCY,APLP2,BCAT1,CAPN2,CCNI,CTBP1,EIF5A,FLNA,FOS,HK1,HMOX1,LIMS1,MAT2A,PREB,SCRN1,SDHC,SMARCA4,SURF1,THBS1,TOMM22,VDAC1,VPS4A	Akt,ELK1,ERK,FLT1,JUN,MYC,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,VEGFA,nitric oxide	
P3	 	MGEA5	-1.135	enzyme	 	-0.516	 	-0.067	0.000	3.70E-08	ACO2,ACTG1,ADRM1,AIFM2,ALDOC,ALOX5AP,APOE,ARPC4,ASS1,ATP5I,ATP5L,BCL2L1,C1QA,C1QB,C3AR1,CALCRL,CD14,CD151,CD53,CD68,CDK6,CEBPB,CSF1R,CXCL16,DAB2,DCLK1,EFNB1,EPHB3,FAS,FLNA,FSCN1,GAA,GLUL,HMGCS1,HPGDS,HSP90AB1,IGFBP3,IGFBP4,MCAM,MMP14,MSMO1,NDUFA11,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFB9,NDUFC2,NDUFS4,OGDH,PLAU,PLCE1,PLIN2,SERPINE2,SLC33A1,SOCS3,SORBS1,SOX9,SREBF2,THBS1,THRA,TNFRSF12A	Alpha catenin,CHUK,CTNNB1,Insulin,MGEA5,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53	
P3	 	EDN1	-4.850	cytokine	 	1.245	bias	0.558	 	4.48E-08	ACTB,ADAM12,ADIPOQ,ANXA1,ANXA5,ARF6,CALCRL,CDC42,CTGF,CYBB,EDNRB,EGR1,FOS,FOSB,FST,GRN,HIF1A,HSPA5,HSPA8,ITGAV,JUNB,LEP,MARCKSL1,MBP,MCAM,MMP9,NPM1,NUPR1,ODC1,PDGFA,PDIA6,PLAU,PLCB4,PRKCE,RPSA,SOCS3,SOD1,THBS1,TPM3,VCAM1	CEBPA,CREB1,EDN1,ERK1/2,HRAS,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PRKCE,RELA,SP1,STAT3,TNF,TP53	
P3	 	L-dopa	 	chemical - endogenous mammalian	Inhibited	-2.684	 	0.076	-3.424	5.30E-08	ADGRB2,AGPAT1,AIF1,AIFM2,ALPL,ARAP1,AREL1,ARL3,BANF1,C1QA,C9orf24,CA12,CAPG,CASK,CD63,CEBPG,CHAC1,CHST11,CLDN5,CLIC6,CLN6,CNR1,COMT,CRYM,CTSB,CXCL12,DCTN3,DGAT2,DUSP1,DUSP6,EDNRB,EIF4G2,EIF6,FKBP5,FOS,FOSB,FTL,GAPDH,GLB1,GNA13,GPC3,HCST,HEXA,HLA-A,HRAS,HSPB6,HTATIP2,IL11RA,JUNB,LAMP2,LAPTM5,LASP1,MAP3K1,MAT2A,MBP,MMP14,MSMO1,NAB2,NAGLU,NDUFA8,NDUFS4,NTRK3,NUAK1,PCDHGB4,PCYT2,PDGFA,PLEK,PLEKHO2,PPP1R1B,PPP1R2,PPTC7,PSAP,RERG,RHOBTB2,RILPL1,SCRN1,SH3BGRL3,SHC1,SIAH2,SLC24A2,SLC25A44,SLC29A3,SLC2A6,SMPD3,SOX9,SRM,SRPRB,STAB1,STXBP1,SYPL1,TAX1BP3,TRIB3,TRIOBP,VAT1,VDAC1,WDR1	CREB1,CREBBP,CREM,Creb,DRD1,ERK1/2,HTT,L-dopa,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,STAT3,estrogen receptor	
P3	 	APOE	5.721	transporter	 	-0.908	bias	-0.399	1.041	5.76E-08	ACTB,ADAMTS5,ADIPOQ,APOB,APOE,APP,CALR,CCND2,CD68,CSF1,CTGF,CTSB,CTSD,CTSS,CYBB,CYR61,EGR1,FKBP4,FKBP5,FOS,HMOX1,HSP90AB1,HSPD1,IGFBP6,IL10RA,IL1RN,LEP,LIPA,LRP8,MAPT,MMP9,MSR1,NR1H3,PLAU,PTP4A3,PTX3,SDC4,SOCS3,SOD1,SPP1,SREBF2,TNFRSF1A,VCAM1,WBP2	APOE,CEBPA,CEBPB,HIF1A,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	tunicamycin	 	chemical - endogenous non-mammalian	Activated	3.664	bias	0.390	1.359	6.01E-08	ADCYAP1R1,ASNS,ATF4,CALR,CCND3,CEBPB,CHAC1,CLDN5,DDIT3,DGAT2,EDEM1,EGR1,HMOX1,HSPA5,HSPA9,KLF4,LONP1,MMP9,MVD,NARS,NR1H3,PCK2,PDIA6,PDRG1,PLIN2,PRNP,PVR,SCD,SEC61A1,SEC61G,SEL1L,SESN2,SIGMAR1,SLC20A1,SLC7A11,SRPRA,TMED3,TPO,VCAM1,WARS	ATF6,DDIT3,EIF2AK3,ERN1,FOXO1,FOXO3,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53,XBP1,tunicamycin	
P3	 	MEL T1	 	chemical - kinase inhibitor	 	0.632	 	0.089	0.352	6.76E-08	ATP5D,C1QBP,CFL1,COPS8,COX5A,ENO1,FH,HSPD1,PGAM1,PRDX1	 	
P3	 	GnRH analog	 	biologic drug	 	-1.871	 	-0.028	-1.658	7.36E-08	ABCC1,ACTN1,AHCYL1,AP3D1,ASNA1,ATP6V1E1,CALR,CAPNS1,CDK16,CETN2,CHMP2A,CLUH,COL6A1,CYC1,DUSP1,DVL1,DYNLL1,EDNRB,FAS,FKBP1A,FOS,GABARAP,HADHB,HIF1A,HINT1,HSP90AB1,HSPA2,IL11RA,LIMS1,MFAP5,MICU1,MKI67,MPV17,MXRA7,NARS,NME2,NTRK3,NUTF2,PHLDA2,PLD3,PPIA,PSMB7,PVR,RAB5C,RALA,RAN,SFRP1,SLC25A44,SLC7A11,SNRPD3,TCEA1,THRA,TMBIM6,TWF1,VAT1,WSB2,YIF1A	 	
P3	 	cycloheximide	 	chemical reagent	 	-1.975	 	-0.093	-1.305	8.17E-08	ACTB,ADCY1,ADCYAP1,AGFG1,ALDOA,APOB,APP,ASS1,BCL2L1,BTG2,CALR,CCND3,CD4,CEBPB,CSF1,CTGF,CYP4A11,CYR61,DUSP1,EEF1A1,EGR1,ESR2,FAS,FOS,FOSB,FST,GBP1,GCLM,GOT1,HEXA,HMOX1,IGFBP4,IGFBP6,IL1RN,JUNB,KCND3,LARP6,LEP,LONP1,MT-CO1,MYOC,NFE2L2,NPM1,NQO1,NR1H3,NR4A1,PDGFA,PFKFB3,PLAT,PLAU,PTX3,RERG,RHOBTB2,SCD,SLC30A1,SOCS3,SPP1,THBS1,THRA,VCAM1	APOE,CEBPA,CTNNB1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,cycloheximide	
P3	 	IND S7	 	chemical - kinase inhibitor	 	-1.387	bias	-0.254	-0.472	8.39E-08	ACTB,ATP5D,C1QBP,COPS8,COX5A,ENO1,ERP29,FH,PCK2,PGAM1,STIP1,TUBB,VDAC2	 	
P3	 	cisplatin	 	chemical drug	Activated	2.720	 	0.208	1.003	1.01E-07	ABCC3,ACTB,ADRM1,AKR1C1/AKR1C2,ANXA1,ANXA2,ANXA5,ARHGEF10L,ASNS,ATF4,ATP6V0C,BCL2L1,BHLHE41,BIRC7,BTG2,CAPN2,CAPN6,CD14,CD53,CSF1,CTGF,CTSB,CXCL14,DDIT3,DGKE,DMXL2,DUSP1,DUSP6,EGR1,ERBB4,FADS3,FAS,FCGR2A,FOS,GAS5,GDF15,GSTM3,GSTP1,HIF1A,HK1,HMGCS1,HMOX1,HSPA5,HYAL1,IGFBP3,IL10RA,LIPA,LMO4,LRP6,LYZ,MBD4,NCAM1,NEO1,NQO1,ODC1,PCNXL2,PEBP1,PFKL,PHLDA3,PLAT,PPIA,PSMB10,RGL1,RHOBTB2,RPL13A,RPS16,RPS21,RPS27L,RPS5,RRM2B,S100A11,SESN2,SLC31A1,SLC39A3,SLC6A6,SOCS3,SOD1,SPP1,TFPI,THBS1,TMSB10/TMSB4X,TNFRSF12A,TNFRSF1A,TOP2A,TP63,TUBB,TYMP,UBE2A,UCP2,VCAM1,XRCC6	CEBPA,CTNNB1,FOS,IL6,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,cisplatin	
P3	 	miR-16-5p (and other miRNAs w/seed AGCAGCA)	 	mature microrna	Inhibited	-5.550	bias	-0.710	 	1.07E-07	ACP2,ACTR1A,ANLN,ARHGDIA,ARL2,ATG9A,CA12,CCND2,CCND3,CDK6,CREBL2,DTD1,EIF4G2,GFPT1,GRN,GSTM4,HMGA1,HMOX1,IPO4,PAFAH1B2,PANX1,PHLDB2,PLAG1,PPIF,PSAT1,RAD51C,RTN4,SERPINE2,SLC25A22,SLC38A1,SLC7A1,SQSTM1,SRPRA,SRPRB,TMEM43,TPM3,TPPP3,TXN2,UCP2,UTP15	 	
P3	 	bardoxolone	 	chemical drug	Activated	2.777	 	0.237	1.901	1.08E-07	CEBPB,CEBPG,DDIT3,EPHX1,FTH1,GCLM,HMOX1,HSPA9,MDH2,NQO1,NQO2,SQSTM1,TXNRD1,UQCRFS1	 	
P3	 	EGFR	1.095	kinase	 	1.611	bias	0.282	-0.285	1.26E-07	ACTB,ANXA1,BCL2L1,C12orf49,CDK6,CEBPB,CHI3L1,CLDN2,CMA1,COL5A2,COL6A1,COL8A1,CTGF,CXCL12,DDIT3,DUSP1,DUSP4,EGR1,EIF6,ERBB4,ESR2,FOS,GAS5,GBP1,GPC1,GRN,HIF1A,HNRNPK,HOXA7,HSD11B2,HSPA5,IGFBP3,IGFBP4,JUNB,MATN2,MMP14,MMP9,MT1M,PLAT,PLAU,PPIA,PSMB5,PSMB6,PSMB7,SERPINE2,SFRP1,SLC4A7,SOCS3,SOX9,THBS1,TNXB,TUBB4B,TUBG1	CTNNB1,EGF,EGFR,ERBB2,ERBB4,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	IRS1	1.077	enzyme	 	-0.181	bias	0.308	-1.179	1.59E-07	ACTR3,ADIPOQ,BMP6,CEBPB,CIDEA,COL6A1,COX7A1,DDIT3,EGR1,FHL1,FMO1,FOS,GAS5,IGFBP4,LEP,MMP14,NDN,NR2F1,PCK1,PDGFA,PHB,SFRP2,SPP1,SREBF1,SREBF2,THRA,TNXB,TRIB3,UCP2	AKT1,ATF4,CEBPA,CEBPB,E2F1,FOXO1,FOXO3,INS,IRS1,Ins1,Insulin,NR4A1,PPARA,PPARG,RELA,SIRT1,SP1,SREBF1,TP53	
P3	 	amino acids	 	chemical - endogenous mammalian	 	-0.343	 	-0.213	0.315	1.68E-07	ACTB,ASNS,DDIT3,FOS,FOSB,GAPDH,HIF1A,JUNB,ODC1,RPL32,SLC7A1,SLC7A2	CEBPA,ERK1/2,FOXO1,HIF1A,IGF1,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TSC2,amino acids	
P3	 	miR-122-5p (miRNAs w/seed GGAGUGU)	 	mature microrna	Inhibited	-2.429	bias	-0.710	 	1.74E-07	AACS,ADAM17,ALDOA,BCKDK,EEF1A1,EGLN3,FAM117B,G6PC3,GYS1,NCAM1,PKM,PSME1,PSME3,RABIF,SLC35A4,SLC7A1,SLC7A11,TMED3,TTYH3,XPO6	 	
P3	 	EPO	-6.527	cytokine	 	1.336	bias	0.364	-0.473	1.85E-07	ACTB,ATP6V1B2,BCL2L1,BZW2,CCND2,CCND3,CD52,CLGN,CREG1,CXCL12,DDIT3,DES,EEF1A1,EGR1,ETF1,FAS,FECH,FOS,FOSB,GBA,GLUL,GSPT1,H2AFZ,HMGN1,ILF2,JUNB,KIT,LAPTM5,LCP1,LY6E,MID1IP1,MLH1,NAB2,NPM1,NUPR1,PLCB2,RAB4A,RCC2,RPLP0,RPS4Y1,SDHC,SOCS3,SOD1,SPP1,TFRC,TIE1,TSN,UCP2,UGCG,WDR1	ELK1,EPO,ESR1,FOS,FOXO1,FOXO3,GATA1,JUN,MXI1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SPI1,STAT3,TP53,nitric oxide	
P3	 	Insulin	 	group	 	1.291	 	0.229	-0.233	2.16E-07	ACTB,ADIPOQ,ALDOA,APOE,APP,BCL2L1,CCND3,CEBPB,CIDEA,CYBB,DUSP1,DUSP4,EGR1,FOS,FOSB,FTL,GSK3B,GSTP1,HIF1A,HMOX1,HNRNPK,HSPA5,IGFBP3,IGFBP4,LEP,MAPT,MDH2,ME1,MMP9,MT-ND1,MTCH2,NDUFA1,NDUFB9,NR1H3,NR4A1,NUCB2,ODC1,OGT,PCCB,PCK1,PKM,PLIN1,RPL32,RPS16,SCD,SLC25A11,SLC25A5,SLC2A5,SLC38A3,SLC7A1,SORBS1,SREBF1,SREBF2,THRSP,TPO,UCP2	ATF6,CEBPA,D-glucose,HIF1A,Insulin,L-triiodothyronine,LEP,MYC,NCOR1,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,SREBF1,STAT3,STAT5B,THRB,TNF,oleic acid	
P3	 	beta-naphthoflavone	 	chemical toxicant	Activated	3.523	bias	0.320	2.397	2.27E-07	ABCC3,AKR1C1/AKR1C2,APOE,CYP1B1,CYP4A11,CYP4B1,CYR61,FOS,FTH1,GCLM,GSTM5,GSTP1,MAFG,ME1,NQO1,NR4A1,SAA1	AHR,BACH1,CTNNB1,EP300,ESR1,FOS,Jnk,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA,SP1,STAT3,TP53,benzo(a)pyrene,beta-naphthoflavone	
P3	 	CD28	2.371	transmembrane receptor	Inhibited	-3.349	bias	-0.346	-0.789	2.39E-07	ACTR3,AHCYL1,ANXA1,AP1B1,BCL2L1,BIN1,CCND2,CCND3,CDK6,CLIP1,CYC1,CYCS,DAD1,FCER1G,FKBP2,FOS,FYB,GAPDH,GBP1,GYS1,HAX1,HDAC2,HINT1,HMGN1,HSPA8,IFRD2,IGFBP6,IL10RA,ILF2,IRF8,KLF2,LCP1,MAF,MMRN1,MSR1,MT-CO1,NR4A1,OAZ1,ODC1,PGAM1,PHB,PHB2,PSMA5,PSMF1,RAD23B,RPL30,SLC25A5,SLC5A3,SLC7A5,SOCS3,SRPRB,STIM1,TCF7,TFRC,THBS1,XRCC6	CD28,CD3,CTNNB1,ELK1,ESR1,HIF1A,IL2,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,RNA polymerase II,SP1,STAT3,STAT5B,Shc,TCR	
P3	 	ESR2	-2.429	ligand-dependent nuclear receptor	 	-0.641	 	0.091	-1.167	2.46E-07	ADAMTS5,AES,ANO2,APOE,ARRDC4,ATF5,BCAT1,BCL2L1,BIN1,CA12,CADM3,CAPN2,CES1,CHST2,COL16A1,CPM,CTGF,CTSD,CXCL12,CYP2B7P,DNAJC1,DUSP10,EGR1,ESR2,FHL1,FOS,GCSH,GLB1,GM2A,GSTP1,HSPA2,IGFBP3,IGFBP4,IMPDH2,IP6K3,JUNB,KAZALD1,KCNK15,KLF4,LAPTM5,LEP,LIMCH1,ME2,MKI67,MMP14,MPC1,NID2,OTUB2,PCBD1,PDGFA,PLIN2,PPP1R3C,PSAT1,PTGFR,PTX3,RALA,SCUBE1,SEMA3B,SOCS3,SPP1,STON1,TENM4,TESK1,THRSP,TMEM2,TSPO	4-hydroxytamoxifen,AHR,CEBPA,E2F1,ESR1,ESR2,HIF1A,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,beta-estradiol	
P3	 	FMR1	1.540	translation regulator	Inhibited	-2.210	bias	-0.516	 	2.54E-07	ALDOA,APP,ATP5L,ATP6V1E1,CFL1,ENO1,GAPDH,MAP1B,MMP9,PCLO,PLAT,PPIA,PRKACA,RPSA,UQCRFS1,UQCRQ	 	
P3	 	SOD1	1.861	enzyme	 	-1.264	bias	-0.492	-0.204	2.67E-07	ACTB,ALDOC,APOE,ASS1,ATF4,AURKAIP1,BCL2L1,C1QA,CD14,COMT,CSF1R,DCXR,FOS,FTH1,GCLM,GSTM3,GSTM5,GSTP1,GUK1,HMOX1,HN1,HSPA4,HSPA8,JUNB,MMP9,MT-CO1,MT-ND1,NDUFV3,NFE2L2,PSMB5,SH3BGRL3,SNCG,SOD1,SPP1,SQSTM1,STIP1,TFRC,VAPA,VCAM1	Akt,BACH1,CEBPA,CREB1,ELK1,ETS2,JUN,KEAP1,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SOD1,SP1,STAT3,TNF,nitric oxide	
P3	 	AKT1	1.379	kinase	Activated	3.475	bias	0.307	1.659	2.69E-07	ADIPOQ,AKR1C1/AKR1C2,ASS1,BCL2L1,C1QC,CCND2,CCND3,CD4,CIDEA,COL8A1,EGR1,FAS,FOS,FOSB,GCLM,GDF15,GSTM5,HIF1A,HMGCS1,HMOX1,LEP,LIPA,MBP,ME1,MMP14,MMP9,MSMO1,MSR1,NEXN,NFE2L2,NQO1,PCK1,PLP1,PPP1R1B,SCD,SLC3A2,SLC4A7,SPP1,SREBF1,SREBF2,STUB1,TGFB2,THBS1,UNC5B	AKT1,Akt,CEBPA,CEBPB,CREBBP,ELK1,ESR1,IFNG,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TNF,TP53	
P3	 	IL1B	-1.412	cytokine	 	1.732	bias	0.318	-1.297	3.01E-07	ABCB11,ABCC3,ADAMTS5,AIF1,AKR1B1,ALPL,ANXA1,APOB,APOE,APP,ARL6IP5,ASS1,ATF4,ATF5,BCL2L1,BMF,BTG2,CD14,CD4,CD83,CEBPB,CEBPG,CFTR,CHI3L1,CSF1,CSRNP1,CTGF,CTSB,CTSS,CXCL12,CYBB,DAB2,DDIT3,DUSP1,EGLN3,EGR1,F13A1,FAM129A,FAS,FGFR2,FKBP5,FOS,FOSB,FST,G0S2,GBP1,GDF15,GEM,GM2A,GRN,GSK3B,GYS1,HEXA,HIF1A,HLA-A,HMGA1,HMOX1,HPGDS,IGFBP3,IGFBP4,IGFBP6,IL10RA,IL1RN,IRAK1,ITGAV,JUNB,LCP1,LEP,LGALS9,MAPT,MARCKSL1,MMP14,MMP9,NFE2L2,NFKBIZ,NQO1,NR1D1,NR1H3,NR4A1,ODC1,PCDH7,PGAM1,PLAA,PLAT,PLAU,PLD3,PSMB10,PTGFR,PTX3,RAN,RNASE1,RPSA,SAA1,SAA2,SCUBE1,SDC4,SERPINH1,SLC20A1,SOCS3,SOX9,SPP1,SREBF1,TACR1,THBS1,THRSP,TMEM176B,TREM2,TYMP,UGCG,USP18,VCAM1,XYLT1	CEBPA,CEBPB,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	WT1	-7.752	transcription regulator	 	1.385	 	0.118	0.739	3.01E-07	AHCY,APLP2,APRT,ARL2,ASNS,ATP5I,BCL2L1,BTG2,CSF1,CSF1R,CSPG4,CTGF,EGR1,FGF1,FIBP,FOSB,HCFC1R1,IFRD2,IRF8,JUNB,KLF4,KPNA1,MMP14,MMP9,NCSTN,NME1,NQO2,ODC1,PCK2,PDGFA,PIR,PPIB,RPL19,SLC20A1,SLC6A6,SOX9,SQSTM1,SREBF2,TARS,THBS1,TYROBP,WARS,YARS	CEBPA,CEBPB,CTNNB1,FOXO1,IGF1,JUN,NFKB1,NFkB (complex),RELA,Ras,SP1,STAT3,TP53,WT1	
P3	 	RNA polymerase II	 	complex	 	 	 	 	 	3.05E-07	ACTB,ADIPOQ,ALAS1,ALPL,ASNS,ATP13A2,CA12,CBX5,CCND2,CD14,CD4,CD83,CDH11,CSF1,CYP1B1,DDIT3,DUSP1,ENO1,FOS,GAPDH,GDF15,GOT1,HCST,HOXA7,HSD11B2,IGFBP3,IL1RN,JUNB,MINOS1,MMP9,NR5A2,OSGIN1,PCDHAC2,PCK1,RBBP8,RPL12,RPL13A,RPS21,RPS3,SDHC,SOCS3,SORBS1,SPP1,TIAL1,TXN,XIST	MYC,NFKBIA,RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	tamoxifen	 	chemical drug	 	0.001	 	0.071	-0.441	3.05E-07	ABCB11,ASS1,BCL2L1,CDH11,CDK6,CTSD,CXCL12,CYR61,EPHX1,ERBB4,ESR2,ETV5,F13A1,FLOT1,FNDC4,FOS,G0S2,GAPDH,GDF15,GJB2,HMGCS1,HSP90AB1,IGFBP3,IGFBP4,IL1RN,JUNB,MKI67,MT-CO1,NNMT,PFN1,RERG,SCD,SDC3,SEMA3B,SHC1,SLC5A3,SLC7A2,SLC7A5,SOX9,SPP1,SQSTM1,SREBF1,TXN,TYMP,UCP2,UGCG	CEBPA,CEBPB,ELK1,ESR1,ESR2,HIF1A,IGF1,JUN,MYC,NFE2L2,NFKB1,NFkB (complex),RELA,RNA polymerase II,RXRA,SP1,STAT3,TGFB1,TP53,calcitriol,nitric oxide,tamoxifen	
P3	 	PI3K (family)	 	group	Activated	2.512	bias	0.359	0.855	3.65E-07	AKR1C1/AKR1C2,CCND3,CLDN2,CTSD,CXCL12,DDIT3,EGLN3,FOS,GCLM,HIF1A,HK1,HMOX1,HSPA5,KLF2,LEP,MMP9,NFE2L2,NQO1,PKM,SIAH2,SLC4A7,SREBF1	AKT1,ARNT,Akt,CEBPB,CREBBP,ELK1,ESR1,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,PI3K (family),PPARG,RELA,SP1,STAT3,TP53	
P3	 	tert-butyl-hydroquinone	 	chemical reagent	Activated	3.088	bias	0.618	 	3.65E-07	ABCC1,AKR1C1/AKR1C2,CNR1,FOS,FTH1,FTL,GCLM,GSS,GSTM3,GSTM5,GSTP1,HMOX1,HSPA5,HSPA8,JUNB,MAF,ME1,NFE2L2,NQO1,OSGIN1,SESN2,TXNRD1	AHR,BACH1,CTNNB1,ESR1,FOS,Jnk,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA,SP1,STAT3,TP53,tert-butyl-hydroquinone	
P3	 	HIF1A	2.212	transcription regulator	Activated	3.473	bias	0.510	 	3.87E-07	ADAM17,ADIPOQ,ALDOA,ALDOC,APOE,ASNS,ATG9A,BCL2L1,BHLHE41,CARS,CTGF,CTPS1,CTSD,CXCL12,CYR61,EGLN3,EIF5A,ENO1,ERBB4,ERGIC1,FAM162A,FHL1,FOS,FSCN1,GAPDH,GBE1,HIF1A,HIST1H2BK,HMOX1,HSPA4,HSPA5,IGFBP3,ITGAV,ITGB2,LEP,METTL23,MMP9,MT-ND1,NPM1,NR4A1,P4HA1,P4HA2,PDGFA,PFKFB3,PFKL,PHLPP1,PKM,PLOD2,PPIA,RAB20,RET,SDC4,SESN2,SFRP1,SOCS3,SOX9,STC2,SULF1,TFRC,TGFB2	AHR,ARNT,Akt,CEBPB,CTNNB1,ERK1/2,ESR1,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P3	 	KRAS	1.004	enzyme	Activated	4.104	 	-0.003	4.122	4.12E-07	ACTR3,ALDOA,AOX1,APLP2,BCL2L1,BSG,CCND3,CEBPB,DCLK1,DDIT3,DUSP4,DUSP6,EEF1A1,EIF5,EIF5A,ETV5,FAS,FOS,FTH1,GBA,GLUL,GNA13,GPC3,GRN,HADHB,HEXA,HIF1A,HSPA5,HYOU1,LAMP2,MCAM,MT-CO1,NCAM1,NFE2L2,NME2,NQO1,NR5A2,OAS1,PLAT,RAB20,RAB7A,RNH1,RPSA,SDC4,SERPINE2,SIRPA,SLC3A2,SMPD3,SOX17,SOX9,SQSTM1,TCEA1,TCP1,THBS1,TOP2A,UBE2I,VAPA	Akt,CTNNB1,EGFR,HIF1A,JUN,KRAS,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	MKNK1	1.060	kinase	Activated	3.400	bias	0.710	 	4.19E-07	ANXA2,ANXA5,AP3D1,BAG3,CYR61,FAM49A,FLNA,FOS,FOSB,GPC4,HSPA2,MAP1B,MAPT,MYO5A,NCDN,PLTP,RNH1,SERPINH1,SFRP1,STRN4,STXBP1,THRA,TMBIM6,TPP1,YWHAG	 	
P3	 	let-7a-5p (and other miRNAs w/seed GAGGUAG)	 	mature microrna	Inhibited	-4.469	bias	-0.710	 	4.33E-07	ATP6V1F,BCL2L1,BSG,CAPG,CCND2,CDK6,CHMP2A,COL27A1,DAD1,DSP,EIF4G2,GRPEL2,GYS1,HMGA1,HMOX1,HRAS,HYOU1,IPO4,MMP9,MTPN,POLD2,RHOG,SCD,SEPT3,SIGMAR1,SLC1A4,SLC25A1,SLC25A13,SLC38A1,SYPL1,THBS1,TMEM2	 	
P3	 	mibolerone	 	chemical drug	Activated	3.562	 	0.226	2.339	4.62E-07	ALCAM,BMP6,CALR,CLTC,DAD1,DNAJA4,EIF2S1,EIF4A1,ERP29,FHL1,FKBP1A,FKBP5,GPC3,HMGCS1,HSPA5,HYOU1,IGFBP3,MAT2A,NME1,NME2,PPIA,PPIB,PRELP,SEC23B,SLC25A5,SRM,TMED3,TOP2A,UCP2,USP18	 	
P3	 	CTNNB1	1.109	transcription regulator	 	1.097	bias	0.565	 	4.85E-07	ABCC1,ACTB,ACTR3,ADAM17,ADIPOQ,AES,ALCAM,ALDH1A2,ALDH3A2,ALG3,ANXA1,APP,ARHGDIA,BCAP31,BCL2L1,BMF,C6,CALM1 (includes others),CAPNS1,CAPZB,CCND2,CD4,CDH11,CLDN2,CLDN5,CNR1,COL27A1,CRAT,CTGF,CTNNA1,CXCL12,CYR61,DDIT3,DES,EDIL3,EIF5A,EPHB3,ESR2,F13A1,FAS,FCER1G,FOS,FST,FSTL3,GJB2,GLUL,GNA12,HNRNPA0,HSPE1,HTATIP2,ID4,IMPDH2,IRF8,ITGB2,LFNG,LIPA,LRP6,LY6E,ME1,MECOM,MMP14,MMP9,MPEG1,NCAM1,NR5A2,PDAP1,PFN1,PHLDA2,PLAU,PSAP,RAD23A,SAA1,SCD,SCRN1,SEC61A1,SERPINA1,SERPINE2,SFRP1,SLC1A5,SOX17,SOX9,SPP1,SQSTM1,STARD7,STXBP1,SYNM,TCF7,TIAL1,TMEM2,TP63,UGCG,VCAM1,WNT5B	CEBPA,CEBPB,CTNNB1,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,TP53	
P3	 	PTEN	-1.115	phosphatase	 	-1.782	 	-0.043	-1.468	5.01E-07	ACO2,ADIPOQ,AKR1C3,ALG3,ANXA1,ARHGDIA,ATP5G1,ATP5I,BTG2,CA12,CBX4,CCND3,CDK6,CEBPB,COX5A,COX8A,CSTF3,CTSB,CYP27A1,DEGS1,DUSP1,FAS,FOS,G0S2,GYS1,HADHB,HIF1A,HOXA10,ID4,IFI30,IGFBP3,IGFBP6,KIF3B,LIMS1,MAT2A,MBP,MKI67,MMP14,MMP9,MT-ATP6,MT-CYB,MT-ND1,MVD,NR5A2,PABPC4,PFKFB3,PFKL,PLAU,POLD2,PTP4A2,PTPRC,PTPRK,RAD51C,SCD,SDC4,SLC20A1,SLC25A1,SMARCA4,SNRPF,SOCS3,SPP1,SREBF1,TAF10,TAF13,THBS1,VCAM1,ZBTB16	CEBPA,CEBPB,CREBBP,ELK1,ERK1/2,ESR1,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),PTEN,RELA,SP1,STAT3,TNF,TP53	
P3	 	KDM5A	1.107	transcription regulator	Inhibited	-5.014	bias	-0.623	 	5.57E-07	ACO2,ATP6V1F,COA3,COX14,COX17,COX4I1,GHITM,GRPEL1,HMOX1,ICT1,MAP2K3,MRPL17,MRPL55,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFS4,NME1,PARK7,PGD,SDHC,TOMM22,TOMM6,TXN2,UQCRC1,UQCRFS1,UQCRQ,VDAC1	 	
P3	 	IL13	-10.582	cytokine	Activated	3.281	bias	0.297	1.087	5.59E-07	ALDH1A2,ALOX5AP,BCL2L1,BZW2,C3AR1,CAPN2,CD14,CD209,CD4,CD52,CEBPB,CHCHD7,CHI3L1,CHST2,CLDN2,CTGF,CTSB,CTSS,CYBB,DMXL2,DNASE2,DUSP10,EGR1,F13A1,FAM162A,FAS,FCGR2A,FKBP1A,FLOT1,G0S2,HK1,HMOX1,IARS,IL11RA,IL1RN,LIPA,MAF,MCUR1,MMP14,MMP9,MS4A4A,MSMO1,NCLN,NHLH1,PDGFA,PLAU,PLCXD1,QSOX1,SERPINA1,SLC7A2,SOCS3,SPP1,ST3GAL6,STXBP1,SYNGR2,THBS1,TNFRSF1A,TNS1,TPSAB1/TPSB2,VCAM1	CEBPA,CEBPB,CTNNB1,FOS,FOXO1,IL13,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF	
P3	 	VEGFA	-1.274	growth factor	Activated	2.669	bias	0.543	 	6.15E-07	ABCC1,ALAS1,ATP5J2,CD83,COX8A,CSTB,CTGF,CTSB,CTSS,CXCL12,CYB5B,CYR61,DUSP4,EGR1,ETV5,FOS,GBP1,HIF1A,HK1,HMOX1,IGFBP4,JUNB,MDH2,ME2,MMP9,NDUFA1,NME1,NME2,NR4A1,PLAT,PLAU,SCO2,SHMT2,SLC25A5,SLC25A6,SNCG,SYNM,THBS1,TIMM13,TMSB10/TMSB4X,TOMM22,TSPO,TXN2,UNC5B,VCAM1	CTNNB1,FGF2,FOS,FOXO3,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,TP53,VEGFA	
P3	 	BACH1	 	transcription regulator	Inhibited	-2.143	bias	-0.382	-1.097	6.20E-07	CALM1 (includes others),FTH1,GCLM,HMOX1,ME1,NQO1,SLC7A11,SPP1,SQSTM1,TTC23	BACH1,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA	
P3	 	FGF2	1.798	growth factor	Activated	2.373	bias	0.361	-0.118	6.37E-07	ADAMTS5,AKR1B1,ATF4,BCL2L1,BTG2,CCND2,CCND3,CDH11,CNP,CSF1,CXCL12,CYR61,DAD1,DDIT3,EDNRB,EGR1,ENO1,ETV5,FAS,FGFR2,FLNA,FOS,FTH1,GBP1,HIF1A,IGFBP3,IGFBP4,JUNB,LRP6,MAPT,MBP,MCAM,MKI67,MMP9,NR4A1,ODC1,PDGFA,PLAT,PLAU,PRKCE,SCD,SFRP1,SLC20A1,SOCS3,SOX9,SPP1,SPRY4,SQSTM1,TFPI,TGFB2,THBS1,TNFRSF12A,TOP2A,TPO,VCAM1,XRCC6	CEBPA,FGF2,HGF,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),NOTCH1,P38 MAPK,RELA,SP1,STAT3,TNF	
P3	 	sulindac sulfide	 	chemical drug	 	-0.203	 	-0.104	0.246	6.49E-07	APP,ARPC1B,BCL2L1,CEBPB,CTGF,CYB5B,CYP1B1,DYNLL1,EGR1,GARS,GDF15,MSMO1,NQO1,NUTF2,PGAM1,PLAU,PPP2R1A,RRM2B,STC2,XRCC6	APP,CTNNB1,ERK1/2,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SP1,STAT3,TP53,sulindac sulfide	
P3	 	desmopressin	 	biologic drug	 	-0.063	bias	0.355	-1.062	6.54E-07	ACTB,AKR1B1,CAPG,CTSD,ENO1,F8,FLNA,FOS,GAPDH,GNG12,HINT1,HSPA8,HSPH1,LIMA1,PHLDB2,PPIA,PPP1R1B,RMDN3,RPS3,S100A11,TNS1,TUBB,VDAC1	 	
P3	 	IL15	-1.946	cytokine	 	-0.095	bias	0.470	-2.337	6.89E-07	ANXA1,ATF4,BCL2L1,CALM1 (includes others),CCND2,CCND3,CD28,CD53,CD83,CDK2AP1,CDK6,CSF1,CTGF,CXCL12,FAS,FKBP1A,FYB,GAPDH,GARS,HCST,HSPA8,HSPE1,ID4,JUNB,KIT,KLRD1,LEP,MAF,MKI67,MYH1,NAGA,NCAM1,NME1,OAZ1,PDCD5,PFN1,PLEK,POLR2K,PRKACA,PSAP,PSMA5,PSMB10,PTP4A2,PTPRC,RBBP8,RPS3A,S100A11,SLC25A5,SORL1,TCEA1,TCF7,TFRC,TNFRSF1A,TOP2A,TXNRD1,TYROBP,VCAM1,YARS	IL15,IL2,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PPARG,RELA,RNA polymerase II,SP1,STAT3,STAT5B,TP53	
P3	 	CSF3	-13.862	cytokine	 	0.683	 	0.181	-0.287	7.04E-07	ARHGDIA,BCL2L1,C3AR1,CAPG,CCND2,CCND3,CD14,CDK6,CEBPB,CTSD,CXCL12,CYBB,DES,DUSP6,EGR1,ERAP2,FOS,HMOX1,HOXA7,HSPD1,IL1RN,ITGB2,KIT,LTF,LYZ,MMP9,NME2,ODC1,PLCB2,PRKCE,SOCS3,TFRC,TNFRSF1A,VCAM1	Akt,CEBPB,CSF3,IFNG,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	IGF1	1.056	growth factor	Activated	3.466	bias	0.415	0.523	7.05E-07	ADIPOQ,AKR1C1/AKR1C2,APP,BCL2L1,BSG,C1QA,CCND2,CCND3,CEBPB,CNP,CSF1,CTGF,CTSD,CYBB,CYR61,DCLK1,DDIT3,EGR1,ESR2,FOS,FOSB,GAPDH,HIF1A,HMGA1,HMOX1,HSD11B2,HSPA5,IGFBP3,IGFBP4,IGFBP6,ITGAV,JUNB,KIF1A,LARP6,LASP1,LEP,MAFG,MAPT,MBP,MKI67,MMP14,NCAM1,NFE2L2,NUPR1,ODC1,PLAU,PLP1,PPP1R1B,PRNP,PTPRC,SCD,SLC12A7,SLC20A1,SNCG,SOCS3,SPP1,SREBF1,THBS1,THRSP,TNFRSF12A,UBE2D2,VCAM1	CEBPA,ERK1/2,FGF2,FOXO3,IGF1,JUN,LEP,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,RELA,SP1,STAT3,STAT5B,TNF,TP53	
P3	 	oleic acid	 	chemical - endogenous mammalian	 	-0.488	 	0.194	-1.416	7.58E-07	APOB,APOE,APP,ATF4,DDIT3,DEGS1,DGAT2,DUSP1,FOS,GAPDH,HMOX1,HSPA5,IGFBP3,NPC1L1,NR1H3,NR4A1,PCK1,PLIN1,PLIN2,PLIN5,SCD,SREBF1,THRSP,UCP2,VCAM1	CEBPA,CEBPB,FOXO1,Insulin,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,fatty acid,oleic acid,palmitic acid	
P3	 	Lh	 	complex	 	-0.465	 	0.196	-1.324	7.82E-07	ACP2,ACTB,ACTN1,ALPL,ARHGAP35,ARL4C,ARL6IP5,ARPC4,CCND2,CDK16,COL15A1,CREBL2,DAB2,DUSP1,DUSP3,FKBP5,FLNC,FOS,FST,GBP1,GEM,GNB1,MAP2K3,MAP4K4,MMP9,MSMO1,NLK,P4HA2,PHB,PLAT,PPP2R1A,PRKACA,PSMD3,PTX3,RAB1A,RAB4A,RAB5C,RAPGEF3,SMARCA4,STIP1,TGFB2,THBS1,TMBIM6,TNFRSF12A	CEBPB,Cg,ERK,GATA1,IL1B,JAK2,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,STAT3,STAT5B,TP53,progesterone	
P3	 	indomethacin	 	chemical drug	Activated	3.087	 	0.209	1.789	7.88E-07	ACOT1,ADAMTS5,ANXA1,ANXA2,APP,ASNS,ATP6V0B,BCL2L1,BSG,BTG2,CAPN2,CAPN6,CBX4,CD14,CEBPB,COX8A,CTSD,DYNLL1,FCGR2A,FOS,GAS5,GBA,GDF15,GSTM3,HIF1A,HMOX1,LIMA1,MMP14,PLIN2,PSMB10,PSMB5,RPS21,S100A11,SLC7A5,SPP1,STRN4,TACR1,TMSB10/TMSB4X,TNFRSF12A,TUBB,UCP2,UQCR10,XRCC6	CEBPA,EGF,IGF1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,SREBF1,STAT3,TP53,indomethacin	
P3	 	VHL	1.103	transcription regulator	 	0.041	bias	-0.277	0.949	7.94E-07	AHCYL1,AIF1,ATF4,BCL2L1,CA12,CFL1,CLTC,CTGF,CXCL12,DAB2,EGLN3,EIF5,FTH1,FTL,GBE1,HIF1A,HMOX1,HYAL1,MAF,MMP14,MYL12B,PFKFB3,PPIL1,PREB,SEC61G,TFRC,TMED3,UQCRQ	ARNT,CEBPB,CREBBP,ELK1,EPAS1,ESR1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT3,TP53,VEGFA,VHL	
P3	 	palmitic acid	 	chemical - endogenous mammalian	 	0.448	bias	0.312	-1.237	8.13E-07	ADCYAP1R1,ADIPOQ,ALDOA,ATF4,ATP5J2,BCL2L1,CIDEA,CNR1,CTGF,CTSB,CYBB,DDIT3,DEGS1,DGAT2,EEF1A1,FOS,GAPDH,GDF15,HMOX1,HSPA5,LEP,NFE2L2,NR4A1,PCK1,PLIN2,SCD,SLC25A1,SOCS3,SQSTM1,SREBF1,TRIB3,UCHL1,UCP2,VCAM1	ADIPOQ,D-glucose,FOXO1,FOXO3,HIF1A,INS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,fatty acid,palmitic acid	
P3	 	phorbol myristate acetate	 	chemical drug	Activated	5.401	bias	0.351	1.727	1.23E-06	ACSM5,ACTB,ADAM17,ADAM9,AHSA1,ALAS1,ANXA1,APP,APRT,B3GNT5,BCL2L1,BMP6,BTG2,CAPG,CCND2,CCND3,CD14,CD209,CD28,CD4,CD52,CD68,CDC42,CES1,CFTR,CSF1,CSF1R,CSTA,CTGF,CTSB,CTSD,CYBB,CYR61,DAB2,DES,DUSP1,EDF1,EGR1,EIF4A1,EIF5A,EIF6,ERBB4,ESR2,FAS,FBXW11,FCER1G,FHL5,FKBP5,FOS,FOSB,FST,FSTL3,FTH1,GDF15,GEM,GPR55,GSTP1,HIF1A,HMBS,HMGA1,HNRNPK,HOXA7,HRAS,HSP90AB1,HSPA4,HSPA5,IGFBP3,IGFBP6,IL1RN,IRAK1,ITGB2,JUNB,KCNK2,KIT,KLF2,KLF4,LIPA,LYZ,MAF,METAP2,MMP14,MMP9,MSR1,MT-CO1,MYH1,NAB2,NME2,NPM1,NQO1,NR4A1,OAS1,ODC1,PAX5,PCK1,PDGFA,PEA15,PKM,PLAT,PLAU,PRDX1,PRKACA,PRKCE,PRNP,PTGFR,PTPRC,RACK1,RPL19,SERPINA1,SETBP1,SFRP2,SLC16A1,SLC7A1,SLC7A11,SNCG,SOCS3,SOD1,SPP1,STK40,TACR1,THBS1,THRSP,TIE1,TNFRSF12A,TPM3,TPO,TRAF3,TYMP,UGCG,VCAM1,VSIG4	CEBPA,CEBPB,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT3,TNF,TP53,phorbol myristate acetate	
P3	 	tetraethylammonium	 	chemical drug	Inhibited	-2.168	 	-0.164	-1.557	1.25E-06	ARHGDIA,ATP5H,BCL2L1,CBX3,FTH1,HSPA8,HSPA9,NDUFS8,PARK7,RPLP0,SARS,SSR4,TCP1,UTP15	 	
P3	 	CEBPB	2.221	transcription regulator	Activated	2.407	bias	0.454	-0.757	1.27E-06	ADIPOQ,AKR1C3,ALDH1A2,ALOX5AP,APOB,ASNS,BCL2L1,CCND2,CD14,CEBPB,CFTR,COL5A2,CSF1R,DAB2,DDIT3,DEGS1,DGAT2,DYNLT1,F8,FAS,FGFR2,FHL1,FOS,FTL,GSK3B,HLA-A,HMGA1,HSPA8,HSPD1,HSPE1,IGFBP3,IGFBP4,IL11RA,IL1RN,LEP,MBP,MSR1,NFE2L1,NFKBIZ,NR1H3,NUPR1,ODC1,PCK1,PEA15,PLXND1,PSMA3,PTGFR,SAA2,SCD,SEMA3E,SEPT3,SERPINA1,SLC7A1,SOCS3,SPP1,SREBF1,TMEM176A,TMEM176B,TNFRSF1A,TRIB3,XIST	CEBPA,CEBPB,CREBBP,FOS,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SMARCA4,SP1,SPI1,STAT3,TP53,cyclic AMP	
P3	 	PML	1.209	transcription regulator	Inhibited	-2.742	 	-0.080	-2.337	1.34E-06	ACTG1,ADIPOQ,AKR7A2,APOE,CFL1,DNAJA4,FAS,FTL,GCLM,HADHB,HMOX1,LEP,LYZ,MAF,NFE2L2,NQO1,PRDX1,SCD,SQSTM1,SREBF1,SREBF2,STIP1,TXN,TXN2,TXNRD1,UCP2,YWHAG	BACH1,CEBPB,CTNNB1,FOXO1,HIF1A,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PML,RELA,RXRA,STAT3,arsenic trioxide,reactive oxygen species	
P3	 	MAP4K4	1.809	kinase	Inhibited	-4.318	bias	-0.710	 	1.35E-06	ACO2,ALDH4A1,ALG14,CEBPB,CYC1,EIF4E2,GLUL,GOT1,GYS1,HADHB,IVD,NDUFA11,NDUFB7,NDUFS4,NDUFS8,OGDH,PDXP,PGAM1,PHYH,PLCB4,POLE3,SCD,SEPHS1,SREBF1,UQCRC1,UQCRFS1	ELK1,MAP4K4,MAPK9,NFkB (complex),PPARG,PPARGC1A,RELA,RXRA,SREBF1,SREBF2,STAT3	
P3	 	Il3	 	cytokine	 	0.766	 	0.237	-0.075	1.41E-06	ATF5,BCL2L1,CCND2,CCND3,CD14,CD68,CSF1,CSF1R,EGR1,FAS,FOS,HRAS,LTF,LYZ,PRKCE,SPP1,TCP1,TNFRSF1A,YWHAG	AKT1,Creb,ELK1,FOXO1,HRAS,IRF8,Il3,JUN,Mek,NFKBIA,NFkB (complex),NR4A1,PPARG,PTPN11,RELA,SP1,SPI1,STAT3,STAT5B,TP53	
P3	 	AMPK	 	complex	 	-1.011	 	0.132	-1.575	1.60E-06	AACS,ACO2,ADIPOQ,BMF,CCND2,CXCL12,CYBB,DUSP4,EGR1,FSCN1,HIF1A,HMOX1,IL1RN,LITAF,MMP9,MT-ATP6,MT-CO1,MT-CYB,MT-ND1,PFKFB3,SLC6A8,SREBF1,STIM1,THRSP,UCP2	AMPK,Akt,CEBPA,Insulin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF	
P3	 	nitric oxide	 	chemical - endogenous mammalian	 	1.421	bias	0.253	0.137	1.68E-06	APP,BCL2L1,CTGF,CXCL12,DDIT3,DUSP1,DUSP6,EGR1,FAS,FOS,FTH1,GCLM,GSTP1,HMOX1,HPGDS,HSP90AB1,JUNB,MKI67,MMP9,MT-CO1,NCAM1,NFE2L2,NQO1,ODC1,PRDX5,RAD23B,SOD1,SPP1,SQSTM1,TFRC,THBS1,TXNRD1	CEBPA,CTNNB1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TNF,TP53,hydrogen peroxide,nitric oxide	
P3	 	mir-122	 	microrna	Inhibited	-4.678	bias	-0.629	 	1.70E-06	ACTR1A,ADGRB2,ALDOA,FKBP1A,GNPDA1,GYS1,H1F0,KIF5B,LETM1,MAP1B,MARK1,NUTF2,PKM,RCC2,SEPT9,SH3BGRL3,SH3GL1,SLC1A5,SLC7A1,VPS4A,WARS,YARS	 	
P3	 	ANGPT2	-1.912	growth factor	Activated	4.702	bias	0.519	 	1.75E-06	ABCC1,ADAM12,ARHGEF2,ARL4C,CALR,CCT7,CD68,CEBPB,COMT,DDIT3,EEF1B2,EFR3A,FAS,FKBP2,FKBP4,GSK3B,HDAC2,HIF1A,HMGCS1,HMOX1,HSPA2,HSPA4,HSPA5,HSPD1,LEP,MAPK10,MMP9,NME1,PDIA6,PLAU,SOD1,SPTLC3,THBS1,TNFRSF12A,UBE2A,VCAM1	ANGPT2,Akt,CTNNB1,FOS,IL6,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3	
P3	 	ADORA2A	-10.517	g-protein coupled receptor	 	0.818	 	0.108	0.268	1.82E-06	ALDOC,APP,ATP6AP1,ATP6V1B2,CCT5,CD28,CLDN5,COL6A1,CSF1R,DGAT2,DUSP1,EIF2S2,EIF5A,FOS,GAPDH,HMOX1,HNRNPK,KIF5B,MMP9,NR4A1,PEA15,PGAM1,PPP1R1B,PPP2R1A,SYT11,TUBB2A,USP5,VPS4A	ADORA2A,CREB1,Creb,JUN,NFKB1,NFKBIA,NFkB (complex),NTRK1,P38 MAPK,Pkc(s),RELA,STAT3,TP53,norepinephrine	
P3	 	maslinic acid	 	chemical - endogenous non-mammalian	 	-1.890	bias	-0.563	 	1.91E-06	ACTN1,ADAM17,ARPC4,BCL2L1,CCND2,CDK6,CEBPB,CFL1,DVL1,FBXW11,FBXW5,GSK3B,IRAK1,JUNB,PLCB2,PRKACA,PRKCE,SHC1,SORBS1,THBS1,YWHAG	Akt,ERK,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,maslinic acid	
P3	 	thioacetamide	 	chemical toxicant	Activated	3.489	bias	0.600	 	1.95E-06	AACS,AKR1C3,ANXA1,ANXA2,ASNS,CAPN6,CD14,CPA3,CTBP1,CTGF,CYGB,DKK3,EDNRB,EMP1,EPHX1,FCGR2A,GAS5,GDE1,GOT1,GSTM3,HK1,HSPA4,IGFBP3,LRP8,MBD4,MMP14,NFE2L2,NUPR1,ODC1,PKM,PLCB4,POR,PPT1,PRELP,PSMB10,PSMD10,S100A11,SLC7A11,SPP1,STEAP3,TMC5,TMSB10/TMSB4X,TNFRSF12A	CEBPA,HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TGFB1,TNF,thioacetamide	
P3	 	NR3C1	-1.079	ligand-dependent nuclear receptor	 	0.977	 	0.120	0.347	2.11E-06	ACTB,ACTN1,ALOX5AP,ANXA1,APOE,APP,ATP6AP1,BAG3,BCL2L1,BIN1,BMF,CAPN2,CBX4,CD83,CEBPB,CIDEA,CLDN5,COMT,CPEB4,CSRNP1,CSRNP2,CYP27A1,CYR61,DAD1,DAPK2,DEAF1,DEGS1,DGAT2,DNAJC15,DUSP1,DYNLL1,EGR1,ELMO2,EMP1,FCER1G,FKBP4,FKBP5,FOS,GEM,GLUL,GPR65,GSTP1,GULP1,HDAC2,HSD11B2,HSP90AB1,IP6K3,IRF8,ITGB2,LEP,LMO4,MKNK2,MMP9,MTCH2,MYOC,NHLH1,NSMAF,PCK1,PDGFA,PEA15,PHLDA2,PLIN2,PPP2R1B,PRKCE,PTP4A2,RRAGC,RTN4,SERPINA1,SGPL1,SH3GLB1,SIAH2,SLC2A5,SLC38A1,SPP1,STK39,STON1,STUB1,THBS1,TNFRSF12A,TNFRSF1A,TPST2,TRAF3,TRIB3,TXN,UBE2K,UGCG,VCAM1,WDR12,YWHAG	Akt,CEBPA,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT3,TNF,dexamethasone	
P3	 	bromobenzene	 	chemical toxicant	 	1.145	 	0.016	1.085	2.27E-06	ABCC1,ABCC3,DDIT3,FMO1,FOS,GAPDH,GOT1,GSTP1,HMGCS1,HMOX1,HSPA13,HSPA5,LONP1,MSMO1,NQO1,NUPR1,POR,RPL28,RPL35	 	
P3	 	sodium arsenite	 	chemical drug	 	0.966	 	0.185	0.266	2.34E-06	ABCC1,AHCY,CDK6,DDIT3,EGR1,FOS,FTH1,GCLM,GSS,HIF1A,HMOX1,HSPA4,LITAF,MAT2A,PCK1,SOCS3	CEBPB,CTNNB1,FOS,FOXO1,IKBKB,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,sodium arsenite	
P3	 	methapyrilene	 	chemical drug	Activated	2.065	 	-0.068	2.360	2.38E-06	ACTG1,ALDOA,ANXA2,ANXA5,APOE,ASS1,ATF4,ATP6V1B2,BTG2,CES1,CTSB,CTSS,CYP4A11,DDIT3,EEF1A1,EIF2S1,GSK3B,GSS,HMOX1,HSPA5,NR2F6,ODC1,PPP1R2,RPL13A,RPS8,SCD,SLC3A2,TUBB,TXNRD1	 	
P3	 	TO-901317	 	chemical reagent	Activated	3.109	 	0.226	2.138	2.57E-06	ALAS1,ALDH3A2,APOC1,APOE,APP,ASS1,BCL2L1,CIDEA,COMT,COX17,CRAT,CYP4A11,ELOVL1,ENO1,EPHX1,FMO1,GBE1,HMGN1,IGFBP4,MID1IP1,MMP9,MPEG1,MRPS2,MRPS7,NR1D1,NR1H3,NR5A2,PCK1,PFKFB3,PFKL,PLTP,POR,PSMA5,PSME1,SCD,SIGMAR1,SREBF1,THRA,THRSP,TKT	CEBPA,FOXO1,Insulin,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,THRB,TO-901317,fatty acid	
P3	 	Sos	 	group	 	 	 	 	 	2.92E-06	ABCC1,ADAM12,AKR1C3,APLP2,CAMK2D,CHI3L1,CLIP1,COL16A1,DAPK2,ENAH,FOS,GBA,GM2A,GSK3B,HMOX1,HPGDS,HSPB8,KIF5B,LRP8,MAP4K4,MLH1,MMRN1,NFE2L2,ODC1,PFN1,PKN1,PLAU,PXK,RAPGEF3,RFNG,RGMA,SCD,SEMA3B,SEMA3E,SIRPA,TPP1,UGCG	CTNNB1,ERK,FOS,JUN,Jnk,KRAS,MYC,NFKBIA,NFkB (complex),RELA,Ras,SP1,STAT3,Sos,TP53	
P3	 	deferoxamine	 	chemical drug	 	-0.368	bias	0.315	-2.019	2.94E-06	ALDOA,APP,CCND2,CCND3,DDIT3,DUSP1,DUSP10,EGLN3,EGR1,ENO1,FOS,GDF15,GEM,HIF1A,HMOX1,HSPA13,IGFBP3,IGFBP4,LEP,MT-CYB,MT-ND5,PFKFB1,PFKFB3,PKM,PLAT,SERPINE2,SPP1,SPRY4,SREBF1,TFRC,TGFB2,VCAM1	AKT1,FOXO1,HIF1A,HTT,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PI3K (complex),RELA,SP1,STAT3,TP53,VHL,deferoxamine,iron	
P3	 	decitabine	 	chemical drug	Activated	2.035	bias	0.539	 	3.07E-06	ABCC1,ABCC3,ALDH1A2,ANXA2,APOE,BTG3,CCND2,CCND3,CDH11,CFTR,CHI3L1,CLDN5,COMT,CTGF,CXCL12,CYP1B1,CYP4B1,DNAJC15,DUSP1,EEF1A1,EEF1B2,EEF1G,ESR2,FAS,FECH,FLNC,GDF15,GLB1,GPC3,GSTP1,HSPB8,IGFBP3,ITGAV,JUNB,KLF4,LAMA2,MAF,METAP2,MKI67,MLH1,MMP14,MMP9,NME1,NQO1,NR1H3,OAS1,PLCE1,RPL26,RPL37,RPL4,RPL9,RPS13,RRM2B,SCN11A,SERPINH1,SFRP1,SHC1,SLC30A1,SNCG,SOCS3,SPP1,TFRC,TGFB2,THBS1,TMSB10/TMSB4X,TOP2A,TP63,UCHL1,WHSC1	Akt,CDKN1A,CEBPB,CREBBP,CTNNB1,ELK1,EP300,ESR1,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,decitabine	
P3	 	resveratrol	 	chemical drug	 	-1.211	 	-0.074	-0.733	3.16E-06	ADAM17,ADIPOQ,AIF1,APP,BCL2L1,BSG,CCND2,CD14,CDK6,CNBP,COX4I1,CSF1R,CYBB,CYP1B1,DDIT3,DYNLL1,EGR1,ESR2,FAS,FOS,GDF15,GLB1,HIF1A,HMOX1,HSPA5,IGFBP3,LEP,LITAF,MMP9,MT-CO1,NDUFA13,NDUFA2,NQO1,PCK1,PDGFA,PLAU,PLIN1,PSMB5,RAN,SESN2,SOD1,SPP1,SQSTM1,TFRC,TGFB2,TNS1,VCAM1	CEBPA,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,TNF,TP53,hydrogen peroxide,resveratrol	
P3	 	docosahexaenoic acid	 	chemical drug	 	-1.397	bias	-0.289	0.178	3.20E-06	ADIPOQ,APOE,APP,ATF4,BCL2L1,CSF1,CTGF,CYCS,DDIT3,FAS,FOS,HMOX1,LEP,MAPT,MMP9,NFE2L2,NPC1L1,PCK1,PLAT,PLTP,SCD,SERPINH1,SMPD2,SOCS3,SORL1,SREBF1,TGFB2,THBS1,TNFRSF1A,UCP2,VCAM1	Akt,CEBPA,CEBPB,FOXO1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,RELA,SP1,STAT3,TNF,docosahexaenoic acid,palmitic acid	
P3	 	mono-(2-ethylhexyl)phthalate	 	chemical toxicant	Activated	2.166	bias	0.622	 	3.37E-06	ACO2,ADIPOQ,ALDOC,ATP5D,CCND2,COX4I1,CYC1,CYP4A11,DGAT2,ENO1,FAS,FH,FOS,GAPDH,GFPT1,JUNB,KIF5B,MDH2,NDUFA2,NDUFB9,NR1H3,OGDH,PCK1,PLIN2,PPTC7,SDHC,SOD1,TALDO1,TKT,TSPO,UQCRC1,UQCRFS1	ADIPOQ,CEBPA,CEBPB,CREBBP,ELK1,ESR1,FOXO1,NFKB1,NFkB (complex),NRF1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,TP53,mono-(2-ethylhexyl)phthalate	
P3	 	GnRH-A	 	chemical reagent	 	-1.898	 	0.158	-2.574	3.60E-06	ADCYAP1,AGPAT1,ANXA5,BTG2,CD53,CD68,CIDEA,EGR1,EIF2AK1,FOS,FOSB,FST,GCNT2,JUNB,KLF4,MNAT1,NFKBIZ,NR4A1,UHMK1	CREB1,CTNNB1,Creb,ELK1,ERK,FSH,GnRH-A,JUN,MAPK9,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,RXRA,SP1,STAT3,TP53	
P3	 	ABCB7	1.257	transporter	 	1.477	bias	0.426	0.533	3.68E-06	FECH,FTH1,FTL,TFRC,TXN	ABCB7,HTT,NFE2L2,VHL,iron	
P3	 	CHUK	1.173	kinase	Activated	2.738	bias	0.585	 	3.71E-06	ARL6IP5,BCL2L1,CEBPB,CSF1,CTSB,CXCL12,DUSP6,ENAH,FAS,FOS,GM2A,GRN,HLA-A,HMOX1,IGFBP6,IL1RN,JUNB,MAT2A,MFAP5,MMP9,MYH1,NAGLU,NR6A1,PCDH7,PLAU,PLD3,PTX3,SERPINE2,SFRP1,SMOC2,SNX10,SOCS3,SPP1,SQSTM1,TMEM176B,TP63,VCAM1	CEBPA,CHUK,IKBKB,IKBKG,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	tanespimycin	 	chemical drug	 	-1.477	bias	-0.352	0.192	3.85E-06	AHSA1,BCL2L1,CALM1 (includes others),CDK6,CYCS,DDIT3,EIF4A1,FAS,HNRNPAB,HSP90AB1,HSPA5,HSPA8,HSPA9,IARS,KIT,PLAU,PRMT5,RPL24,RPL30,RPL35,RPS16,RPS8,SERPINH1,SNRPF,TYMP	CTNNB1,EGFR,FOS,FOXO1,IGF1R,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor,tanespimycin	
P3	 	SPI1	1.361	transcription regulator	Activated	3.553	bias	0.277	2.371	4.18E-06	ACTB,C1QC,C3AR1,CCND2,CD14,CD209,CD68,CHI3L1,CSF1,CSF1R,CTSS,CYBB,DAB2,DDX21,DUSP6,FCER1G,FOS,FTH1,HMBS,HSPA8,IL1RN,IMP4,ITGB2,KIT,KLF4,LTF,LYZ,MBP,NIP7,NOL6,PSMB10,PTPRC,RACK1,RPL18,SNU13,SPP1,TCP1	CEBPA,CSF1R,CTNNB1,FOS,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,SPI1,STAT3,TNF,TP53	
P3	 	dalfampridine	 	chemical drug	 	-1.585	bias	0.621	 	4.24E-06	APP,BTG2,CYR61,DUSP1,DUSP6,EGR1,FOS,FOSB,HSPA8,JUNB,KLF4,NR4A1	CREB1,Creb,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,dalfampridine,norepinephrine	
P3	 	AGT	-1.136	growth factor	Activated	2.720	bias	0.359	0.012	4.31E-06	ADAM12,ADAM17,ADAMTS5,ADIPOQ,BMP6,CALR,CCND2,CCND3,CLGN,COL6A1,COX4I1,COX5A,COX7A1,CTGF,CTSS,CYBB,CYP4A11,DAB2,DUSP1,EDNRB,EGR1,FOS,GABBR1,GALNT13,GFPT1,GSK3B,GSS,GSTM5,GSTP1,HIF1A,HMGCS1,HMOX1,IGFBP3,IGFBP4,ITGAV,KCND3,LEP,MAPT,MATN2,MMP9,MSMO1,MSR1,NR4A1,PDGFA,PFN1,PIR,PLAU,PNKD,POLE3,PPP1R3C,PTGFR,SGCD,SHC1,SLC9A1,SOCS3,SPP1,TFPI,TFRC,TGFB2,TLN2,TNFRSF12A,UCP2,UGCG,VCAM1	AGT,CEBPA,FGF2,FOXO3,HIF1A,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TGFB1,TNF,TP53	
P3	 	CREB1	1.197	transcription regulator	 	0.949	 	0.215	-0.580	4.35E-06	ADRA1A,ALAS1,APOE,ARHGAP35,ATF5,ATP5I,ATP6V0B,ATP6V0D1,BAG3,BCAP29,BCL2L1,BRINP2,BTG2,CARS,CCND3,CD4,CD68,CDH11,CEBPB,COX8A,CPEB1,CRYM,CSRNP1,CYR61,DUSP1,EDIL3,EGR1,FGFR2,FOS,FOSB,GAA,GABARAP,GEM,HLA-A,HLA-G,HMGCS1,HMOX1,HN1,HSPA4,HSPA5,JUNB,LEP,LITAF,MARCKSL1,MAT2A,MCAM,MKNK2,MSMO1,MVD,NAB2,NDUFA4,NEO1,NR4A1,PCDH19,PCK1,PEG10,PLAT,PNO1,RERG,RNH1,SCD,SERINC2,SIAH2,SLC16A1,SMPD3,SQSTM1,SSR4,TAF13,TFRC,TPO,TXN,UQCRQ,WARS2,YPEL1	CREB1,CREBBP,CREM,Creb,EP300,JUN,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,RNA polymerase II,STAT3,TP53,TSH	
P3	 	ERN1	1.678	kinase	 	1.472	bias	0.394	-0.341	4.40E-06	ATF4,CEBPB,CYP1B1,DDIT3,DGAT2,EDEM1,FAS,GOT1,HSPA5,MVD,NARS,NR1H3,PDRG1,PLIN2,PVR,SCD,SCN3A,SEC61A1,SEL1L,SLC20A1,SLC7A1,SPTLC3,SRPRA,SYT11,TMED3,WARS	ATF6,ERN1,FOXO1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,XBP1	
P3	 	LY294002	 	chemical - kinase inhibitor	Inhibited	-4.014	bias	-0.553	 	4.68E-06	ABCC1,AKR1C1/AKR1C2,APOE,ATF4,BCL2L1,BSG,CCND2,CCND3,CD14,CD83,CDK6,CEBPB,CLCN3,CNR1,CTGF,CUBN,CXCL16,CYR61,DDIT3,DUSP1,DUSP4,DUSP6,EGR1,FAS,FOS,FOSB,GBP1,GDF15,GEM,GRN,GSK3B,GSTM3,GSTP1,HDAC2,HIF1A,HMGCS1,HMOX1,HSP90AB1,HSPA5,IFRD2,IGFBP3,IL1RN,INPP4B,ITGAV,JUNB,LEP,LOC102724428/SIK1,MAF,MAT2A,ME1,MMP14,MMP9,NFE2L2,NQO1,NR4A1,NTRK3,PLAA,PLAU,PRDX1,SCD,SLC38A3,SOCS3,SPP1,SREBF1,THBS1,TOP2A,TPO,TYMP,VCAM1,ZBTB16	CEBPA,IGF1,IL1B,JUN,LY294002,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF	
P3	 	SNCA	-1.082	enzyme	 	0.246	 	-0.061	0.381	4.97E-06	AIF1,BCL2L1,CFL1,CRYM,CTSB,CYBB,DDIT3,GSK3B,HSPA5,ITPA,KIF1A,MDH2,MMP9,PSMA3,PYGB,RPH3A,TRIB3,TUBG1,UCHL1,YWHAG	APP,CTNNB1,ERK1/2,HIF1A,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SNCA,STAT3,TP53,baicalein	
P3	 	OSM	-2.713	cytokine	 	1.779	 	0.235	-0.149	5.45E-06	ABCC1,ABCC3,ACSL3,ADAM17,ADAMTS5,AHCYL1,AKR1C1/AKR1C2,AKR1C3,ANXA1,ANXA2,ARF6,ARHGEF2,ARL4C,ASNS,CASK,CBX3,CCND2,CHI3L1,CLIP1,COL6A1,COL8A1,COX7B,CPM,CXCL12,CYP1B1,DEGS1,FOS,GBP1,GFPT1,GLUL,HIF1A,HLA-A,HMOX1,HSD11B2,HSPA2,HSPA5,IGFBP6,IRAK1,JUNB,KCNG1,KIF5B,LITAF,LSM4,MAGED2,MKNK2,MMP9,MPDU1,MSC,NUAK1,OAS1,OGDH,PDAP1,PDGFA,PFKFB3,PLAU,PLCB4,QSOX1,RAB4A,RAD23A,SAA1,SEL1L,SEPT9,SERPINA1,SLC16A1,SOCS3,TECR,TMBIM6,TOP2A,TPO,TYMP,VCAM1,VPS11,ZNF330	CEBPB,CTNNB1,ERK1/2,FOXO1,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),OSM,P38 MAPK,RELA,SP1,STAT3,TGFB1	
P3	 	hexamethylene bisacetamide	 	chemical reagent	Inhibited	-2.267	 	-0.096	-1.923	5.56E-06	ALAS1,CREG1,DDX21,HSPA8,IMP4,NIP7,NOL6,NPM1,RACK1,RPL18,SNU13,TCP1,TFRC	 	
P3	 	ALDH2	-1.923	enzyme	Inhibited	-3.148	bias	-0.710	 	5.65E-06	ATF4,ATF5,GCLM,GSS,PSAT1,SHMT2,SLC1A4,SLC3A2,SLC7A11,SLC7A5	 	
P3	 	doxorubicin	 	chemical drug	Activated	2.582	bias	0.255	0.733	5.89E-06	ABCC1,ABCC3,ANXA1,ANXA2,APP,ASNS,BCL2L1,BTG2,CAMK2D,CAPN6,CD14,CTGF,CTSB,CTSD,CYBB,CYR61,DDIT3,DES,DUSP1,EEF1A1,EEF1B2,EGR1,EIF5A,FAS,FOS,FTH1,GAS5,GDF15,GLB1,GSS,GSTM3,HIF1A,HMOX1,HSPB6,IGFBP6,LIMA1,NCAM1,NFE2L2,NQO1,OSGIN1,PRDX1,PSAP,PSMB10,RRM2B,S100A11,SLC6A6,SOD1,SOX9,SPP1,TNFRSF12A,TNFRSF1A,TOP2A,TP63,TUBB,TXN,UGCG,UQCRFS1	CTNNB1,FOS,IL1B,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TP53,doxorubicin	
P3	 	ACO1	1.077	enzyme	 	-1.387	bias	-0.473	-0.336	6.04E-06	ACO2,APP,FTH1,FTL,GAPDH,IGFBP3,TFRC	ACO1,HTT,NFE2L2,VHL,iron	
P3	 	IL6	-4.267	cytokine	 	1.391	bias	0.374	-1.712	6.21E-06	ABCB11,ABCC1,ABCC3,ADAMTS5,ALAS1,ANXA1,APOB,APOE,APP,ARL4C,BCL2L1,BMP6,BTG2,CD14,CD209,CD53,CD68,CD83,CEBPB,CES1,CES2,CLDN2,COX4I1,CSF1,CTGF,CYBB,CYP1B1,DPP3,DUSP1,DUSP6,DVL1,EGR1,ESR2,FAS,FOS,FSCN1,HIF1A,HLA-A,HMOX1,HSPA5,IGFBP3,IGFBP4,IGFBP6,IL1RN,ITGAV,JUNB,KCTD13,KIT,KLRD1,LEP,LRP6,LTF,LYZ,MAF,MKI67,MMP9,MRVI1,MSR1,NUCB2,PDGFA,PHB,PLAT,PLAU,PRNP,PSMB10,PSME1,PTGFR,PTP4A3,PTPRC,ROR1,SAA1,SAA2,SERPINA1,SH3GLB1,SNX10,SOCS3,SPP1,SRA1,STS,SV2B,TFRC,THBS1,THRSP,TNFRSF1A,TOP2A,TRAF3,TRAF7,VCAM1,WARS,WHSC1,XPNPEP2	CEBPA,CEBPB,CTNNB1,FOXO1,IL1B,IL6,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	mir-1	-2.305	microrna	Inhibited	-3.976	bias	-0.613	 	6.51E-06	ADAM12,ANXA2,CCND2,CEBPB,EML4,GATAD2A,HACD3,HSPD1,LASP1,MMP9,PDGFA,PPIB,PPP2R1B,SEC61A1,SFRP1,SH3BGRL3,SLC25A1,SMARCA4,SOX9,SULF1,TRIM2,TWF1,UST,XPO6	 	
P3	 	cyclosporin A	 	biologic drug	 	-1.228	 	-0.215	0.410	6.83E-06	AKR1B1,ALAS1,ANXA1,ANXA2,APOB,APOE,APP,ASNS,BCAT1,BCL2L1,CADM3,CAPN6,CD14,CD68,CD83,CDH11,CTGF,CYP27A1,EDIL3,EDNRB,EGR1,EIF6,F5,FAS,FCGR2A,FKBP5,FLNA,FOS,FST,GAS5,GNPDA1,GSTM3,HIF1A,HMOX1,HS2ST1,HSPA5,HSPD1,ITGAV,KLRD1,MAF,MDH2,MMP14,MMP9,NME1,NR4A1,ODC1,PKM,PSMB10,S100A11,SCD,SDCBP,SERPINH1,SIAH2,SOD1,SPP1,SREBF1,SREBF2,SSR4,TMSB10/TMSB4X,TNFRSF12A,TUBB,VCAM1,VDAC2	CTNNB1,FOS,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53,cyclosporin A,doxorubicin	
P3	 	sulforafan	 	chemical drug	 	1.792	 	-0.007	1.820	7.06E-06	AKR1B1,AKR1C1/AKR1C2,AOX1,BCL2L1,ENTPD5,EPHX1,FAS,FOS,FTL,GCLM,GSTM5,GSTP1,HIF1A,HMOX1,KEAP1,MMP9,NFE2L2,NQO1,PSMB5,PTPRC,SOCS3,SOD1,TALDO1,TKT,TXNRD1,VCAM1	Akt,BACH1,CEBPA,CTNNB1,FOS,JUN,Jnk,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,sulforafan	
P3	 	rosiglitazone	 	chemical drug	Activated	2.568	bias	0.257	0.674	7.47E-06	ACO2,ADIPOQ,APOC1,APOE,BIRC7,C1QA,C1QB,C1QC,CD68,CIDEA,COX4I1,COX5A,COX7A1,CSF1,CTGF,CYCS,DGAT2,EGLN3,FGF1,FOS,GAPDH,GBP1,GOT1,GPR65,HADHB,HMOX1,HPGDS,HSPA5,HSPA9,IGFBP6,IL1RN,KLF2,KLF4,LEP,LFNG,MAT2A,MDH2,MMP9,MSR1,NR1D1,NR1H3,OAS1,PCK1,PEA15,PHYH,PLIN1,PLIN2,PLIN5,PLTP,PPP2R1B,SCD,SLC27A3,SLC27A4,SLC9A1,SOCS3,SOD1,SORBS1,SREBF1,THBS1,TPM3,UCP2	CEBPA,CEBPB,FOXO1,LEP,NFkB (complex),NRF1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,STAT5B,palmitic acid,rosiglitazone	
P3	 	CST5	-17.113	other	 	-1.809	bias	-0.345	0.478	7.58E-06	ABCC1,ADRM1,AKR1C1/AKR1C2,ANXA2,ANXA5,AP3D1,ARF6,ARHGEF2,BCAP31,CNBP,COPS7A,COPS8,CTSB,DDX21,DKC1,DSP,EBNA1BP2,EEF1B2,EEF1G,FHL1,GNL3,HS2ST1,MAL2,MALSU1,MAP1B,MYL9,NDUFB7,NDUFC2,NHP2,NIP7,NOP10,NPAS2,NR2F1,PRDX1,PYGB,RTN3,S100A11,SEPT3,SGPL1,SLC7A11,SUPV3L1,TOMM22,TXN,VDAC1,VDAC2	 	
P3	 	HOXA10	-5.056	transcription regulator	 	-0.940	 	-0.237	0.415	8.51E-06	ACTB,ADIPOQ,ALDH1A2,ALOX5AP,ALPL,APOE,ARL2,CLDN5,COL15A1,CSTA,CTSG,CYBB,DHRS9,FCER1G,FKBP3,FST,HMBS,IGFBP3,LAMA2,LOC284023,LTF,LYZ,MAP1B,ME1,NCAM1,NR4A1,REM1,RHOG,RPL37A,SCD,THRSP,TNXB,YWHAG	 	
P3	 	inosine	 	chemical - endogenous mammalian	Activated	3.811	bias	0.543	 	8.97E-06	AIF1,ALCAM,ANXA1,ANXA2,ANXA5,ARPC1B,C1QA,C1QB,C1QC,CD63,CD68,FTL,LCP1,PPP1R14B,TSPO	 	
P3	 	6-hydroxydopamine	 	chemical toxicant	Activated	2.277	bias	0.321	0.981	9.06E-06	ATF4,BCL2L1,CALR,CNR1,DDIT3,FOS,FOSB,HSP90AB1,HSPA4,HSPA5,HSPA8,HSPA9,LONP1,MMP9,MT-CO1,NCAM1,PPIB,PSMC4,RPL29,TRIB3	6-hydroxydopamine,CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SNCA,STAT3	
P3	 	Esrra	 	transcription regulator	 	1.198	 	0.142	0.640	1.10E-05	ALDOA,ALDOC,ATP5G1,ATP5J2,COX5A,COX7A2L,COX8A,CRAT,CYC1,CYCS,ENO1,GYS1,NDUFA2,PCK1,PCK2,PFKL,SOX9,SPP1,THRA,UQCR11	Esrra,FOXO1,NRF1,PPARA,PPARG,PPARGC1A,RXRA	
P3	 	PRKCA	1.107	kinase	 	1.984	bias	0.376	0.595	1.10E-05	APP,ARL4C,BCL2L1,CSTA,CTGF,CTSB,CYBB,CYCS,EGR1,FOS,GBA,GDF15,HS2ST1,IGFBP3,MMP9,NQO1,PEG10,PHLDA2,PVR,SDCBP,SZRD1,TGFB2,VCAM1	CREB1,CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PRKCA,PRKCE,RELA,STAT3,TP53,doxorubicin	
P3	 	SNAI1	1.046	transcription regulator	 	0.561	 	-0.131	0.929	1.12E-05	ACTN1,ACTR1A,ACTR3,ADIPOQ,AFAP1,BCL2L1,CCND2,CCND3,CDC42,CFL1,FLNA,FLNC,FOS,LASP1,LIMA1,MMP14,MMP9,MYO5A,PEBP1,TMOD1,TP63,TPM3	Akt,CEBPB,CREBBP,ELK1,ESR1,JUN,NFkB (complex),RELA,SNAI1,SP1,STAT3,TP53	
P3	 	MAFK	-1.214	transcription regulator	 	0.712	bias	0.355	-0.125	1.20E-05	ABCC3,EGLN3,GCLM,GSTP1,HMBS,HMOX1,NQO1,TXN,TXNRD1	BACH1,KEAP1,MAFK,NFE2L2,NFKB1,NFkB (complex),RELA	
P3	 	E2F1	1.002	transcription regulator	 	1.108	bias	0.484	-1.438	1.34E-05	ACTR1A,ACTR3,ADIPOQ,ALPL,BCL2L1,CALM1 (includes others),CALR,CBX5,CCND2,CCND3,CCT4,COPS8,COX4I1,CSE1L,CTSB,DUSP1,DUSP10,DUSP4,EGR1,ERH,FAS,FGFR2,FHL1,FKBP3,FOS,GM2A,GPS2,HLTF,HMGA1,HMGN1,HN1,HNRNPK,HSPA8,HSPD1,HSPE1,KIT,LACTB,LEP,MAF,MLH1,PDCD5,PHB,PSAT1,PSMD2,RAB1A,RAN,RBBP8,RHOBTB2,RPS16,RUVBL1,SLC3A2,SRPRA,STAM,THBS1,TOP2A,TRAF3,TRIM28,TXNL1,TXNRD1,UNG,VCAM1,YARS	Akt,E2F1,ERK1/2,FOXO1,FOXO3,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,SP1,STAT3,TP53,reactive oxygen species	
P3	 	MAFG	2.442	transcription regulator	 	1.091	bias	0.382	0.173	1.42E-05	ABCC3,GCLM,GSTP1,HMBS,HMOX1,MAFG,NQO1,TXNRD1	 	
P3	 	RXRA	1.434	ligand-dependent nuclear receptor	 	0.646	bias	0.307	-0.758	1.43E-05	ABCB11,ABCC3,ACSL3,AHCY,AKR1C1/AKR1C2,ALDH1A2,APOE,APP,ARL4C,ASNS,CCND3,CIDEA,CYP4A11,EPHX1,FOS,FTL,HADHB,HIF1A,HMOX1,LTF,MBP,MID1IP1,NDUFC2,NME1,NPC1L1,NR1D1,NR1H3,NR5A2,PCK1,PCK2,PLIN1,PLTP,RET,SCD,SORBS1,SPP1,SREBF1,SREBF2,TCF7,TGFB2,TPP1,TXN	CEBPA,CTNNB1,FOXO1,JUN,L-triiodothyronine,MYC,NCOR1,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,THRB,alitretinoin	
P3	 	FGF1	3.843	growth factor	 	1.441	 	-0.107	1.906	1.46E-05	AKR1B1,APOE,CDH11,COX5A,CTGF,CYR61,DUSP6,EGR1,FOS,GCLM,GSTM5,GSTP1,HMOX1,NFE2L2,NQO1,NR1H3,ODC1,PDGFA,SLC7A2,SPP1,TGFB2,THBS1,TNFRSF12A,VCAM1	APOE,CEBPA,CTNNB1,Creb,ELK1,FGF1,FGF2,FOXO3,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SP1,STAT3,TNF,TP53	
P3	 	bexarotene	 	chemical drug	 	-1.113	 	0.202	-2.166	1.49E-05	AKR1C1/AKR1C2,AKR1C3,ALCAM,ALDH1A2,APOE,APP,ARL6IP5,ASNS,BMP6,CEBPG,CLIC6,CYCS,CYR61,DUSP1,ERBB4,GARS,IGFBP6,MAF,MMP9,ODC1,PLAT,PLOD2,PNO1,SCD,SIAH2,SLC7A1,SLC7A5,TGFB2,VCAM1	CEBPA,FOXO1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,THRB,TNF,bexarotene	
P3	 	DYSF	1.278	other	 	 	 	 	 	1.55E-05	ACTG1,ACTR3,ANXA1,ANXA2,C1QB,CD53,CD68,CD83,CHMP1A,CTSS,ETF1,FTL,GPR65,HLA-A,LCP1,LYZ,MPEG1,PSAP,TMEM123	 	
P3	 	CREBBP	1.057	transcription regulator	 	-0.323	bias	0.464	-2.160	1.64E-05	ADAM12,ADCYAP1,ALAS1,ARHGEF10L,CAMK2D,CAPG,CCND2,CCND3,CD53,CRISPLD2,CSF1,CTSG,CXCL12,CYBB,CYR61,DDX3Y,DGKE,DUSP1,DUSP4,EGR1,EPSTI1,FOS,FOSB,GM2A,GNG2,HLA-G,HMGCS1,IL10RA,KCTD1,KLF2,MAF,MAFG,MMP9,MYH1,NFE2L2,NPAS2,NR4A1,NTRK3,PCK1,PPFIBP2,RAPGEF3,RGL1,RNF157,SDC4,SDHC,SERPINE2,SLC7A11,SOCS3,SREBF1,THRSP,TNFAIP8L2,USP18,VCAM1,WNT5B,XIST,XRCC6	ADIPOQ,CREBBP,E2F1,EP300,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	TNFSF11	-11.652	cytokine	Activated	3.022	bias	0.560	 	1.65E-05	ADRA1A,AIF1,BCL2L1,BSG,C3AR1,CAPN2,CCND3,CD14,CD83,CSF1R,DAB2,DUSP1,FAS,FOS,GRN,HMOX1,IL11RA,IL1RN,IRF8,ITGAV,JUNB,KEAP1,MARCKSL1,MMP9,NAB2,NFKBIZ,NR1H3,PAG1,PCDH7,PDGFA,PHLDA3,POR,PTPN23,RGL1,SDC4,SEL1L,SIGMAR1,SLC20A1,SOCS3,SPP1,VCAM1	CEBPA,CEBPB,CHUK,CTNNB1,FOS,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TNFSF11,TP53	
P3	 	butyric acid	 	chemical - endogenous mammalian	 	-0.254	 	0.071	-0.738	1.68E-05	ACP2,ADCY1,ALPK2,ANXA1,ANXA2,ANXA5,BCL2L1,CALM1 (includes others),CCND2,CD300C,CD83,CDC42,CDH11,CDK6,CETN2,CLCN3,COL5A2,CPA3,CSF1,CYCS,CYP4A11,DUSP1,EIF4G2,FOS,FTH1,G0S2,GAA,GRN,GSTP1,H2AFZ,HADHB,HK1,IFI30,IGFBP3,KIT,KLF4,LEP,LY6E,MKI67,MMP9,NME1,NPM1,NR4A1,PAX5,PCK1,PFKL,PHB,PLAT,PLAU,PLCB2,PRDX1,PRKACA,PSAP,SOCS3,SOX9,SPP1,SREBF1,THRA,TOP2A,TWF1,UQCRQ	CDKN1A,CEBPA,EP300,JUN,LY294002,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,TP53,butyric acid	
P3	 	TFEB	2.094	transcription regulator	Activated	2.844	bias	0.669	 	1.73E-05	APP,ARSA,CLCN7,CTSA,CTSB,CTSD,GBA,HEXA,NAGLU,PSAP,SGSH,TPP1	 	
P3	 	okadaic acid	 	chemical toxicant	 	0.101	 	0.231	-0.915	1.92E-05	ANXA1,APP,BCL2L1,CCND2,CCND3,CYBB,CYP1B1,EGR1,FOS,FOSB,IL1RN,JUNB,KLF4,MAPT,MMP9,ODC1,SAA1,SPP1,SQSTM1,THRSP	ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,TP53,okadaic acid	
P3	 	NRF1	-1.071	transcription regulator	Activated	3.450	bias	0.338	2.284	1.98E-05	ALAS1,COX4I1,COX5A,COX7B,COX8A,CYCS,FTH1,GCLM,HMOX1,IL1RN,NQO1,PVR,SURF1,VDAC1	 	
P3	 	PI3K (complex)	 	complex	Activated	2.727	bias	0.479	-0.105	2.03E-05	ADAM12,ATF4,BCL2L1,CCND2,CCND3,CEBPB,CTGF,CTSD,CYBB,DDIT3,DUSP1,FOS,GCLM,GSTM5,GSTP1,HIF1A,HK1,HMOX1,IL1RN,ITGB2,KLF2,LASP1,LEP,MCAM,MMP14,MMP9,MT-CO1,NFE2L2,NME1,NQO1,NUPR1,PPP1R1B,SLC12A7,SLC9A1,SNCG,SOCS3,SOX9,SPP1,SREBF1,THBS1,TP63,TYMP,UGCG,VCAM1	AKT1,Akt,CEBPA,FOXO1,JUN,LY294002,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF,TP53	
P3	 	histidinol	 	chemical - endogenous mammalian	 	1.400	bias	0.710	 	2.06E-05	ASNS,ATF4,EGR1,SLC7A1,SLC7A5	 	
P3	 	HGF	1.354	growth factor	Activated	2.843	bias	0.519	 	2.24E-05	ARPC5,ASNS,BCL2L1,CALCRL,CALM1 (includes others),CD28,CNBP,COPB1,CSE1L,CSF1,CTGF,CYR61,DDIT3,DDX21,DES,DKC1,DOK5,DUSP4,DUSP6,DYNLL1,EGR1,EMP1,FASTK,FKBP5,FLNA,FOS,FOSB,GBA,GEM,GNA13,HK1,HMOX1,IGFBP3,IGFBP4,IRF8,LGMN,LRP8,LSM1,MAP2K3,MAPKAPK2,MAT2A,MKI67,MMP14,MMP9,MPC1,NAB2,NID2,NR4A1,NR5A2,PDGFA,PGAM1,PHB,PHLDA2,PLAU,PVR,SFRP1,SLC20A1,SLC7A1,SOCS3,SPP1,STAB1,TACR1,TGFB2,THBS1,TNFRSF1A,TP63,VCAM1	CEBPA,CTNNB1,ERK1/2,FOS,HGF,HRAS,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,TP53	
P3	 	homocysteine	 	chemical - endogenous mammalian	Activated	2.083	bias	0.330	0.719	2.27E-05	ANXA2,ATF4,BCL2L1,CLDN5,CXCL12,DDIT3,DES,EEF1A1,FGF1,HMOX1,HSPA5,LEP,PRDX1,SAA1,SOCS3,SREBF1,SREBF2,TRIB3,VCAM1	Akt,CTNNB1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,SREBF1,SREBF2,STAT3,cholesterol,homocysteine	
P3	 	TSC2	1.679	other	 	-1.570	bias	-0.318	-0.255	2.67E-05	ANXA1,ANXA2,ATF4,CCND2,CCND3,DDIT3,EGR1,FAM129A,FOS,HIF1A,HMOX1,HSPA5,NTRK3,PHLPP1,PRELP,S100A11,SCD,THRSP,TMEM176A,TMEM176B,UCP2	AKT1,Akt,CEBPB,CTNNB1,ERK1/2,FOXO1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PI3K (complex),RELA,SP1,STAT3,TP53,TSC2	
P3	 	17-alpha-ethinylestradiol	 	chemical drug	 	0.870	 	0.224	-0.087	2.70E-05	AARS,ABCB11,ABCC3,APOB,APOE,ASNS,ATF4,BCAT1,C1QB,C1QC,CD53,CD68,CSF1R,CTSS,EIF2S2,ESR2,FOS,IFI30,MMP9,NME1,ODC1,SERPINH1,SLC25A5,SLC38A3,SLC4A2,UHMK1,VCAM1	17-alpha-ethinylestradiol,CEBPA,CEBPB,ESR1,ESR2,IFNG,IL6,JUN,MYC,NFE2L2,NFKB1,NFkB (complex),RELA,SP1,SREBF1,SREBF2,STAT3,TP53,cholesterol,lipopolysaccharide	
P3	 	L-triiodothyronine	 	chemical - endogenous mammalian	 	1.667	 	0.229	0.096	2.86E-05	ACTB,ADAMTS5,ADIPOQ,APOB,APOC1,APP,ARSA,ATIC,CCT4,CNR1,COX4I1,COX5A,CTGF,CXCL12,CYP4A11,DUSP1,DVL1,EGR1,ETF1,FAS,FH,FLYWCH2,FOS,FUOM,HIF1A,HINT1,IGFBP3,IGFBP4,LEP,LYZ,MBP,ME1,MMP14,MMP9,NME1,NR1D1,NR1H3,NR4A1,NR5A2,ODC1,PCK1,POR,RET,SCD,SLC9A1,SORBS1,SREBF1,SRM,THRA,THRSP,UCP2	AGT,CEBPA,CEBPB,FOXO1,HIF1A,Ins1,Insulin,JUN,L-triiodothyronine,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,THRB	
P3	 	camptothecin	 	chemical drug	Activated	2.334	 	0.208	1.097	2.90E-05	ALDOA,ANXA2,APOE,ARFGAP1,ARHGDIA,BCL2L1,BTG2,BTG3,C11orf68,CD300C,CD53,CD83,CDK6,CHAC1,CHCHD7,CHST11,CIDEA,CSF1,DUSP10,DUSP6,EEF1A1,EEF1B2,F5,FAS,FKBP3,FOS,FOSB,FSCN1,GAPDH,GDE1,GRINA,HIF1A,HLA-A,HLA-G,IGFBP3,IL10RA,KIF3B,LIMCH1,LITAF,MAP4K4,MARCKSL1,MFSD5,MMP9,MNAT1,MYO5A,NR4A1,PHLDA2,PLIN2,PPFIBP2,PPIA,PPIF,PSMD2,PTP4A2,PTPRK,PTX3,PYCARD,RRAGD,RRM2B,SAA1,SDC4,SIAH2,SLC25A5,SLC30A1,SORL1,SPP1,STC2,TFRC,TIAL1,TLN2,TPP1,TRAF3,TUBB,TUBB2A,TWF2,UBE2A,UGCG,VAC14,VCAM1	ARNT,Akt,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TP53,camptothecin	
P3	 	PLN	-1.500	transporter	 	 	 	 	 	3.09E-05	ACTB,AK1,ALDH3A2,ALDOA,ANXA2,DES,ENO1,HRAS,PRKCE,RAB10,RAB1A,RACK1,RALA,SOD1,SPTB	 	
P3	 	SP1	1.126	transcription regulator	Activated	3.757	bias	0.618	 	3.11E-05	ALDH3A2,ALPL,APOE,ASNS,ASS1,ATP6V0C,C1QBP,CCND2,CCND3,CD28,CDK6,CEBPB,CES1,CHI3L1,COL8A1,CTGF,CTSD,CXCL12,CYC1,CYP1B1,EGR1,FAS,FLNA,FOLR2,FOS,GDF15,GSS,HADHB,HDAC2,HIF1A,HINT1,HMGA1,HMOX1,HSD11B2,HSPA5,ID4,IGFBP3,IGFBP4,ITGAV,KIT,KLF4,LIPA,MAT2A,MMP14,MMP9,NAB2,NPTXR,NR5A2,PCK1,PDGFA,PKM,PLAA,PLAU,PRKCE,SERPINE2,SH3GL1,SLC25A5,SLC31A1,SLC4A2,SLC4A7,SLC7A1,SNCG,SOD1,SOX9,SPP1,SPTB,SREBF1,TGFB2,TSPO,TXNRD1,UGCG	APP,CDKN2A,CTNNB1,FOXO3,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,SP1,STAT3,TP53,VEGFA,Vegf	
P3	 	IgG	 	complex	 	-1.192	bias	-0.331	0.541	3.18E-05	APOE,APP,ATP6V0D1,BCL2L1,CALR,CCND2,CEBPB,CLDN5,CSF1,CSNK2B,CYP27A1,DDIT3,DEGS1,DSP,DUSP1,EMP1,FCGR2A,FOSB,FST,GUK1,HSPA5,IL1RN,MMP9,PEA15,PHLDA2,PPIF,TRIM16,TUBB2A,UGCG,VCAM1	CEBPA,CSF1,ELK1,ETS2,IgG,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	methotrexate	 	chemical drug	 	0.249	 	0.108	-0.339	3.26E-05	ACTB,ACTG1,ALDOA,ASS1,BTG2,C1QB,C6,CD28,CES1,CLDN2,CSF1,CTSS,CXCL12,CYCS,CYP4A11,DGAT2,DUSP1,DUSP10,FAS,FKBP3,GAPDH,HADHB,HMGCS1,HMOX1,IGFBP3,MAPKAPK2,MECR,NQO1,PCK1,PEX7,PHYH,PPIA,PRDX1,S100A11,SCD,SOCS3,SOD1,SPP1,VCAM1	Akt,CEBPA,CTNNB1,FOS,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,methotrexate	
P3	 	brefeldin A	 	chemical - endogenous non-mammalian	 	0.768	 	0.032	0.654	3.35E-05	APP,CEBPB,DDIT3,HLA-A,HMOX1,HSPA5,HSPA9,KCND3,KLF4,LONP1,PRNP,SESN2,THBS1	ATF6,CEBPA,DDIT3,EIF2AK3,FOXO3,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53,brefeldin A,lipopolysaccharide	
P3	 	Pln	 	other	 	 	 	 	 	3.88E-05	ACTB,AK1,ALDH3A2,ALDOA,ANXA2,DES,ENO1,HRAS,PRKCE,RAB10,RAB1A,RACK1,RALA,SOD1,SPTB	 	
P3	 	RASSF1	1.629	other	 	-0.662	 	0.169	-1.395	3.90E-05	APOE,CCND2,CREG1,DAB2,EGR1,EMP1,EPB41L3,FOS,GDF15,HIST1H2BC,IGFBP3,KLF4,LITAF,MAP1B,MYL9,PCDH7,SOX9,SPP1,SRPX	AREG,CTNNB1,ERK1/2,FOS,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RAF1,RASSF1,RELA,SP1,STAT3,TP53	
P3	 	FOXO1	-1.616	transcription regulator	Activated	2.014	bias	0.461	-0.789	3.91E-05	ADIPOQ,AFF3,AIFM2,ALAS1,ANLN,ATP6V0B,CDKN2AIPNL,CIDEA,CLDN5,CTGF,CYCS,EGR1,FAS,FOS,FOSB,HMOX1,HSPA5,HYOU1,ITGAV,JUNB,KLF2,KLF4,LAMP2,LEP,LPIN2,ME1,MMP9,MRPL14,MRPL47,MRPL55,MRPS2,MRPS30,MRPS7,MVD,NDN,NDUFA12,NDUFA4,NDUFA8,PAX5,PCK1,PCK2,PSMB6,RAB7A,SCD,SESN3,SREBF1,THBS1,TKT,TRIB3,VCAM1	AKT1,Akt,CEBPA,ERK1/2,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,TP53,fatty acid	
P3	 	ACOX1	-1.240	enzyme	Inhibited	-3.025	 	-0.136	-2.335	3.98E-05	ANXA2,CD63,CRAT,CSTB,CXCL12,CYP4A11,DDIT3,GOT1,GSTP1,HSPA5,LONP1,LPCAT3,MYH1,NFE2L2,NR1H3,NUPR1,PLIN2,RPL12,RPS24,SERPINA1,SLC16A1,SLC20A1,SLC4A4,SQSTM1,TRIB3,UCP2,UGCG	ACOX1,CEBPA,JUN,NFkB (complex),PPARA,PPARG,RELA,RXRA,SREBF1,fatty acid	
P3	 	bicuculline	 	chemical - endogenous non-mammalian	 	-1.680	bias	0.492	-3.356	4.28E-05	APP,BTG2,CYR61,DUSP1,DUSP6,EGR1,FOS,FOSB,HSPA8,JUNB,KLF4,NR4A1	CREB1,CREBBP,Cg,Creb,EP300,ERK1/2,FOS,GNRH1,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,bicuculline,norepinephrine	
P3	 	E. coli serotype 0127B8 lipopolysaccharide	 	chemical - endogenous non-mammalian	 	1.726	 	0.219	0.493	4.33E-05	ADIPOQ,ADRA2A,ANXA1,CD14,CHST11,CTGF,CXCL12,CXCL16,DDIT3,DERL1,EDEM1,EDNRB,FGF1,GJB2,GLUL,GNA13,GNG2,HMOX1,HSPA5,KLF2,PANX1,PCK1,PCK2,PPP1R1B,PRDX5,RACK1,SLC4A2,SLC52A2,SLC7A11,SLC7A5,SOCS3,SYNM	Akt,CEBPA,CEBPB,CTNNB1,E. coli serotype 0127B8 lipopolysaccharide,FOS,IFNG,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53	
P3	 	Collagen(s)	 	complex	Activated	2.191	 	0.220	1.467	4.36E-05	ACTB,ATF4,C3AR1,CD63,CD68,CYR61,DDIT3,EDEM1,IARS,LAMP2,PSAT1,SERPINH1,THBS1	 	
P3	 	CSF1	2.281	cytokine	Activated	2.675	bias	0.509	 	4.51E-05	APOE,BCL2L1,CCND2,CD209,CD68,CPM,CSF1,CSF1R,DUSP1,EGR1,FAS,FCER1G,FCGR2A,FOLR2,FOS,GDF15,HSPA5,IL10RA,IL11RA,ITGAV,JUNB,MMP9,MSR1,PLAU,PTPRC,SFRP1,STAB1,THBS1,TNFRSF1A,VCAM1	CEBPA,CEBPB,CSF1,IFNG,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	HMGA1	3.393	transcription regulator	 	-0.316	 	0.198	-1.304	4.52E-05	ALPL,CCND2,CITED1,CYR61,DAB2,DDIT3,EGR1,FOS,IGFBP3,IGFBP4,JUNB,KIT,KLF2,LY6E,MAPKAPK2,MAPT,MGAT1,MMP9,MVD,PHLDA2,RAN,RPL7A,SDC4,SERPINH1,SOX17,TFEB,TRIM28	CEBPA,CEBPB,CREBBP,ELK1,ESR1,FOS,HMGA1,Ins1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,THRB,TP53,estrogen receptor	
P3	 	SLC13A1	-1.359	transporter	 	-1.789	 	-0.077	-1.444	4.53E-05	ACTG1,AKR1C3,ARRDC2,C6,EDEM1,EEF1G,G0S2,HSPA5,HSPA8,MVD,PCK1,RPL41,RPL8,RPN1,SCD,SLC16A1,SPP1,SRPRA,TUBA1C,YARS	 	
P3	 	PRKCE	2.418	kinase	 	1.632	bias	0.602	 	4.56E-05	ADAM12,APP,BCL2L1,CCND3,CDON,CEBPB,CYR61,EGR1,FOS,HSP90AB1,HSPA5,JUNB,MMP9,ODC1,PDGFA,PRKCE,VCAM1	CEBPB,CSF3,ERK1/2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PRKCE,Pkc(s),RELA,Ras,SP1,STAT3,STAT5B,TP53	
P3	 	MST1	-1.085	growth factor	 	0.103	bias	-0.258	0.871	4.64E-05	BCL2L1,CTGF,FAS,FOS,GPC3,IL1RN,IRF8,MSR1,SPP1	AKT1,Akt,ERK,FOS,FOXO1,IKBKB,JUN,MST1,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,SP1,STAT3,TP53	
P3	 	EIF4G2	1.955	translation regulator	 	1.633	bias	0.710	 	4.73E-05	ACTB,CCND2,CTSD,HIF1A,PLAT,SERPINE2	 	
P3	 	IL5	2.473	cytokine	Activated	5.607	bias	0.674	 	4.78E-05	ALDOA,ALDOC,ANXA2,ASNS,ASS1,ATF4,BCL2L1,CCND2,CCND3,CD63,CHMP1A,CISD1,DDX21,DUSP6,EGLN3,EGR1,ENO1,FAM162A,FAS,GCLM,HIF1A,HIGD1A,HSPA5,HSPH1,IFI30,ITGAV,LFNG,MAT2A,MMP9,NABP1,NDUFV3,P4HA1,PAX5,PDIA6,PKM,PPIF,PSAT1,QSOX1,RPN1,SLC1A5,SLC7A5,SNTB1,STK39	AKT1,CSF2,FOXO1,HRAS,IL5,Immunoglobulin,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	STOX1	-1.753	other	 	 	 	 	 	5.04E-05	ACTG1,AHCY,CALM1 (includes others),MAPT,PSMF1,RAB10,RPL17	 	
P3	 	RRP1B	1.889	other	 	 	 	 	 	5.08E-05	CCND3,CEBPB,HSP90AB1,ITGB2,NLK,RABIF,RPL13,RPL13A,RPL14,RPL19,RPL37,RPL37A,RPS10,RPS19,RPS3,RPS5,RPS8,SERPINE2,SPP1,TOP2A,TUBG1	 	
P3	 	TCF7L2	1.179	transcription regulator	Activated	3.491	bias	0.619	 	5.34E-05	ACOT4,ACSL3,ALDH1A2,ALDH3A2,ANLN,BIN1,CCND2,CD4,CERS2,CNP,CTGF,CTNNA1,DEGS1,ELOVL1,ENTPD5,FBXO8,FGFR2,FH,FKBP1A,FTH1,GCLM,GLUL,GSS,HSPA2,ID4,KIF5B,MAP4K4,MBP,MCAM,ME1,MTMR2,NFASC,PCK1,PI4KB,PLAT,PLP1,PPP1R16B,RHOG,STK39,SYPL1,TAF10,TMEM123,TMEM2,TNS1,TP63,TWF1	CTNNB1,JUN,NFkB (complex),PPARG,STAT3,TCF7L2,TP53	
P3	 	IL4	-2.309	cytokine	Activated	3.440	bias	0.415	0.179	5.40E-05	ACP2,ADRM1,ALAS1,ALDH1A2,ALDOC,ALG3,ALOX5AP,ANXA2,APOE,APRT,ASS1,BCL2L1,BIN1,CAPG,CARM1,CBX3,CCND2,CCND3,CCT3,CD14,CD209,CD83,CDK6,CENPB,CLCN3,CLDN5,CLIP1,CLUH,CSF1,CTGF,CTNNA1,CXCL16,EBNA1BP2,EIF2S1,EIF3G,EIF4A1,EPHX1,F13A1,FAM162A,FAS,FCER1G,FCGR2A,FKBP5,FOS,FOSB,GBE1,IFI30,IGFBP4,IL10RA,IL1RN,IRF8,ITGAV,ITGB2,ITPA,JUNB,KIT,KLRD1,LAMP2,LDLRAD3,LFNG,LPIN2,MAF,MMP9,MSR1,NAB2,NABP1,PAX5,PFKL,PHB,PLAU,PLIN2,PLOD2,PMVK,PREPL,PRNP,PSMB10,PSME1,PSMG1,SIRPA,SLC7A2,SOCS3,SPP1,SQSTM1,SRM,STAB1,STUB1,SYNGR2,SYT11,TACR1,TCF7,TRAF3,TREM2,UQCRC1,VCAM1,XRCC6	CEBPA,CEBPB,FOS,IFNG,IL4,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53	
P3	 	SB203580	 	chemical - kinase inhibitor	Inhibited	-2.842	bias	-0.583	 	5.68E-05	ADAMTS8,ADIPOQ,ALPL,ANXA1,ATP5J2,C3AR1,CD83,CLDN5,CTGF,CYP1B1,DDIT3,DUSP1,EDNRB,EGR1,ENO1,ERP29,FAS,FOS,FOSB,FYB,GSTP1,HIF1A,HMOX1,HSPA5,IGFBP3,IL1RN,JUNB,LIMS1,MAT2A,MMP9,NQO1,NR4A1,P4HA1,PCK1,PDGFA,PLAT,PLAU,PRDX1,RARRES3,RCN3,SLC20A1,SOCS3,SPP1,STC2,TGFB2,THBS1,TRPA1,TYMP,UCP2,VCAM1,XYLT1	CEBPA,CTNNB1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SB203580,STAT3,TNF	
P3	 	MECP2	1.010	transcription regulator	 	-0.576	 	0.047	-0.723	5.91E-05	ACTB,ADAM12,ANXA1,APOE,CAPG,DOCK8,EGR1,FKBP5,GSTP1,HSPA5,IGFBP3,IRAK1,IVD,JUNB,MBP,NPY1R,NR4A1,PLP1,RPH3A,SCN3A,SRPX2,UQCRC1,YWHAB	CEBPA,IGF1,JUN,MECP2,NFkB (complex),SP1,STAT3	
P3	 	15-deoxy-delta-12,14 -PGJ 2	 	chemical - endogenous non-mammalian	 	-0.863	 	-0.226	0.360	6.16E-05	BCL2L1,CCND2,CTGF,CTSB,CTSD,CYBB,DDIT3,EGR1,FKBP4,FOS,FTH1,GCLM,GDF15,GSTP1,HMOX1,KLF4,MMP9,MSR1,NFE2L2,NQO1,P4HA1,PLAU,PRDX1,PTGES2,RARRES3,SLC9A1,SOCS3,SOD1,SPP1,TXNRD1,VCAM1	15-deoxy-delta-12,14 -PGJ 2,CEBPA,CTNNB1,ELK1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),Pkc(s),RELA,SP1,STAT3,TNF,nitric oxide	
P3	 	CHADL	1.408	other	 	-1.265	 	-0.122	-0.878	6.27E-05	CSPG4,FAS,IGFBP3,KLF2,NTRK3,PDGFA,PTX3,SMPD3,SOX9,VCAM1	 	
P3	 	NKX2-3	-1.557	transcription regulator	 	1.881	 	0.007	1.842	6.47E-05	ALPL,ANLN,ASNS,BCYRN1,CD68,CSRNP1,CXCL16,DANCR,DCLK1,F2RL3,FAR2,GALNT15,GBP1,GDF15,GNG12,HNRNPA0,KLF2,KLF4,LGMN,LY6E,MMRN1,MT1M,MYO5A,NR2F1,PSAT1,RPS29,SERPINE2,SHMT2,SRPX,SRPX2,SYT11,TXNDC12,TYMP,USP18,VCAM1	 	
P3	 	ADRB	 	group	 	-1.854	 	-0.247	-0.625	6.49E-05	AACS,ANXA5,ATF5,CD68,CDK6,DDIT3,FAS,FOS,GCLM,GDF15,HMGCS1,HMOX1,HSPD1,JUNB,KLF4,MMP9,MSMO1,MVD,NQO1,NR4A1,PCYT2,RAN,SLC7A11,SQSTM1,SRM,TRAF3	ADRB,CEBPB,CREBBP,ELK1,ERK,ESR1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,Ras,SP1,STAT3,TP53	
P3	 	CD38	-1.838	enzyme	Activated	3.305	bias	0.617	 	6.51E-05	ALDOA,ALDOC,ANXA2,ASNS,ASS1,CCND2,CISD1,CLCN3,EGLN3,FAM162A,GBE1,HIGD1A,IFI30,LFNG,NABP1,NCAM1,NDUFV3,P4HA1,PAX5,PDIA6,PFKL,PKM,PSAT1,RPN1,SLC7A5,SOCS3,STK39,VCAM1	CD38,CEBPB,IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P3	 	rifampin	 	chemical drug	Activated	2.574	bias	0.514	 	6.53E-05	ABCB11,ABCC1,ABCC3,AKR1C1/AKR1C2,ALAS1,C9orf72,CARS,CD14,CES1,CES2,CFL1,COL6A1,CSF1,CYP2B7P,CYP4A11,CYP4B1,EIF5,GSTP1,MATN2,ME1,MRPL47,PCK2,PNRC2,SPP1,TSN,TWF2,USP18	FOXO1,NRF1,PPARA,PPARG,PPARGC1A,RXRA,rifampin	
P3	 	SREBF1	1.980	transcription regulator	Activated	2.298	bias	0.468	0.426	7.08E-05	AACS,AARS,ADIPOQ,ALDOC,ATOX1,BCL2L1,BHLHE41,CAPZB,CEBPB,COL6A1,DGKQ,FAS,HMGCS1,HMOX1,HSPA13,HSPA5,IMMT,LEP,MSMO1,MVD,NR1H3,PCK1,PCK2,PMVK,PPAT,RPLP0,RPS24,SCD,SREBF1,STXBP1,THRSP,UCP2,UQCRFS1	CEBPA,CEBPB,D-glucose,HIF1A,Ins1,Insulin,JUN,MYC,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,SP1,SREBF1,SREBF2,STAT3,fatty acid	
P3	 	benzyloxycarbonyl-Leu-Leu-Leu aldehyde	 	chemical - protease inhibitor	Activated	2.667	bias	0.333	0.599	7.31E-05	ACTB,AKR1B1,AKR1C1/AKR1C2,APP,ATF4,BCL2L1,CCND2,CCND3,CEBPB,CFL1,CTGF,CTSB,DDIT3,DUSP1,EIF5A,FAS,FOS,G0S2,GSTP1,HIF1A,HMOX1,HSPA4,HSPA5,HSPA8,HSPA9,HSPD1,MAT2A,MLH1,MMP9,NFE2L2,NQO1,PEBP1,PFN1,PPIA,PSMA3,PSMC4,PSMD2,PTGFR,RHOBTB2,RPLP0,SOD1,SQSTM1,TXN,VCAM1	Akt,CEBPA,CTNNB1,FOS,HRAS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TNF,TP53,benzyloxycarbonyl-Leu-Leu-Leu aldehyde	
P3	 	ESRRA	2.553	ligand-dependent nuclear receptor	Activated	2.791	bias	0.652	 	7.32E-05	ALAS1,ALDOC,CYCS,ENO1,FAM102A,GAPDH,GOT1,HK1,HMGCS1,LIPA,LTF,MINOS1,MTCH2,NDUFA1,NR1D1,PCK2,PKM,PLIN1,SMARCA4,THRA	ESRRA,FOXO1,NRF1,PPARA,PPARG,PPARGC1A,PPARGC1B,RXRA	
P3	 	5-azacytidine	 	chemical drug	 	1.888	bias	0.594	 	7.35E-05	ANXA2,BCL2L1,CALR,CTNNA1,CXCL12,DUSP1,ESR2,ETV5,GDF15,GSTP1,HSPA5,HSPA8,HSPD1,IRF8,KEAP1,MLH1,NPC1L1,PLAU,SHC1,SLC3A2,SLC7A5,SLC9A1,SOCS3,SOX9,THBS1,TUBB	5-azacytidine,CEBPB,CREBBP,ELK1,ESR1,SP1,TP53	
P3	 	IL2	-3.053	cytokine	Activated	3.068	bias	0.441	0.123	7.64E-05	ABCC1,ARHGDIA,ATF5,BCL2L1,CCND2,CCND3,CD28,CD3G,CD83,CDK6,CSF1,CSF1R,CSRNP1,CTPS1,CXCL12,CYCS,CYP27A1,DAPK2,DDX21,DKC1,DUSP4,DUSP6,EMP1,FAS,FCER1G,FGFR2,FOS,GAPDH,GARS,GDF15,GNL3,HCST,HSPA5,HSPD1,IL10RA,KIT,KLRD1,LAPTM5,LY6E,MAF,MAPKAPK2,MMP25,MMP9,NAB2,NDUFA12,NME1,PAX5,PEA15,PHB,PHB2,PHLDA2,PPAT,PTPRC,RPL21,SESN3,SLC30A1,SOCS3,SPP1,STAM,STIP1,TIAL1,TNFRSF12A,TNFRSF1A,TRIB3,VDAC1,YARS	CSF2,Creb,ELK1,IL2,IL4,IRF8,Immunoglobulin,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P3	 	MYOC	-7.839	other	 	1.226	bias	0.389	0.077	7.68E-05	ANXA1,CDH11,CNP,DAB2,DDIT3,FSCN1,HOXA7,HSPA5,LAMA2,MBP,NFASC,PHLDA2,PLP1,SESN2,SFRP1,SLC7A11,SPP1,STC2,VAPA	CTNNB1,ERBB2,JUN,MYOC,NFKBIA,NFkB (complex),SP1,STAT3,TCF7L2,TP53,estrogen receptor	
P3	 	Creb	 	group	 	0.082	bias	0.557	 	7.70E-05	ADCYAP1,ADIPOQ,ARPC5,CD14,COL8A1,CSF1R,CTSB,DCTN3,DUSP1,DUSP4,EGR1,ETV5,FAS,FCER1G,FOS,FSCN1,GABBR1,GSTM3,GSTM4,HLA-G,HSPB8,JUNB,LASP1,LEP,LMO4,MAT2A,MCAM,MT-ND5,NDN,NR4A1,PCK1,PLAT,RET,SESN3,SOD1,SOX17,SOX9	CREBBP,Creb,EP300,HIF1A,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	ONECUT1	-3.227	transcription regulator	 	 	 	 	 	7.82E-05	AASS,ABCB11,ACSS3,ATG9A,CLCN4,CLDN2,COL5A3,COPS7A,COX4I1,COX7A2L,CYGB,EIF4A1,ELOVL1,EMG1,EXOSC5,FADS3,FAS,GSS,GUF1,HLA-G,HSPH1,ITGAV,LRRC59,MAGED2,NUTF2,PCK1,PFKFB1,PFKL,PHB2,PI4KB,RMND1,RPLP1,SERPINA1,SLC25A13,SNRPD2,TCF7,TMBIM6,TMEM126B,TRUB2,TXNDC12,VWA5A,WDR12	 	
P3	 	U0126	 	chemical - kinase inhibitor	 	-1.813	bias	-0.466	1.316	8.18E-05	ABCB11,ADIPOQ,ALPK3,ARHGEF2,ATF4,BCL2L1,BMP6,CCND2,CCND3,CEBPB,CFTR,CLDN2,CSF1R,CTGF,CYBB,CYP1B1,DAB2,DDIT3,DES,DUSP1,DUSP10,DUSP4,DUSP6,EDNRB,EEF1A1,EGR1,EMP1,ETV5,FGFR2,FKBP5,FOS,FOSB,G0S2,GDF15,GRN,GSK3B,HIF1A,HMOX1,HSP90AB1,HSPA5,JUNB,KIFC3,LAMP2,LEP,MAT2A,MMP9,NR4A1,NXPH4,PLAU,PLIN1,PRELP,SH2B3,SHB,SIRPA,SOCS3,SOX9,SPP1,STC2,TGFB2,THBS1,TMEM184B,TPM3,TYMP,VCAM1	CEBPA,EGF,ERK1/2,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53,U0126	
P3	 	FLI1	1.153	transcription regulator	Activated	2.421	bias	0.426	0.913	8.34E-05	CCND3,CSF1R,CTGF,DDX21,EGR1,HSPA8,IMP4,NIP7,NOL6,NPM1,RACK1,RPL18,SNU13,TCP1	 	
P3	 	NCSTN	2.474	peptidase	Inhibited	-2.111	bias	-0.394	-0.802	9.55E-05	APP,CD14,CD68,CEBPB,CSF1R,CTSG,FCER1G,FCGR2A,GRN,IRF8,S100A1	NCSTN,NFkB (complex),NOTCH1,RELA,STAT3,TP53,YY1	
P3	 	CHRM3	-1.384	g-protein coupled receptor	 	-1.342	bias	0.710	 	9.69E-05	CYR61,EGR1,FOS,HMOX1,LEP,MMP9	CEBPA,CEBPB,CHRM3,CTNNB1,FOS,Ins1,Jnk,LEP,MMP9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B	
P3	 	Fe2+	 	chemical - endogenous mammalian	 	-1.698	bias	-0.323	-0.915	9.69E-05	APP,HIF1A,HMOX1,SREBF1,SREBF2,TFRC	AKT1,CEBPA,FOXO1,Fe2+,IGF1,JUN,LDL,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PI3K (complex),PPARA,RELA,Ras,SP1,STAT3,TP53	
P3	 	staurosporine	 	chemical - kinase inhibitor	 	-0.666	 	-0.093	-0.272	9.80E-05	ANXA5,BCL2L1,BTG2,CD28,CD53,CFTR,CREG1,FAS,FCGR2A,FOS,HMOX1,ITGB2,MMP9,NQO1,NR4A1,ODC1,PCK1,PHB,PLAT,PLAU,PRDX1,RPS11	CEBPA,CTNNB1,ERK,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,staurosporine	
P3	 	AHR	-1.151	ligand-dependent nuclear receptor	 	-0.253	 	0.058	-0.567	9.92E-05	ACTN1,ADAMTS5,ALDH1B1,APP,BTG2,BZW2,CCND3,CHST2,COL16A1,COL27A1,COL5A2,COL6A1,COX8A,CTSD,CYP1B1,DMXL2,DUSP6,FAS,FGFR2,FOS,GHITM,GOT1,GSTM5,HIF1A,HSPA5,HSPH1,JUNB,KIT,KLF2,MATN2,NFE2L2,NID2,NNMT,NQO1,PCK1,PLAT,POMP,SAA1,SHB,SIM1,SLC1A4,SLC25A51,SOD1,SPP1,TGFB2,THBS1,TXN	AHR,Akt,IL6,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TP53	
P3	 	DTX1	1.152	transcription regulator	 	0.333	 	0.142	-0.093	9.97E-05	DUSP6,EGR1,HIGD1A,LY6E,MAP3K1,SPP1,SPRY4,TGFB2,UHMK1	AKT1,DTX1,FOXO1,IL2,NFkB (complex),NR3C1,NR4A1,RELA,RNA polymerase II,SP1,STAT5B,TP53	
P3	 	POLG	1.117	enzyme	 	 	 	 	 	9.97E-05	COX7A2L,EEF1B2,RACK1,RPL13,RPL14,RPS16,RPS19,RPS24,RPS5	 	
P3	 	Immunoglobulin	 	complex	 	-0.916	 	-0.015	-0.828	1.01E-04	APP,BCL2L1,C3AR1,CALR,CCND2,CCND3,CD28,CD83,CDK6,CRISPLD2,CSF1,CSF1R,CYP1B1,DUSP1,EGR1,FAS,FCER1G,FCGR2A,FOS,FOSB,HMOX1,IFI30,IL10RA,KLF4,KLRD1,MAPT,MMP9,PAX5,PDGFA,PDIA6,RPS11,SIRPA,STAB1,TFRC,TYMP,VCAM1,ZBTB16	CEBPA,CEBPB,HIF1A,IFNG,IL2,IL4,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,RNA polymerase II,SP1,STAT3,STAT5B,TNF,TP53	
P3	 	atorvastatin	 	chemical drug	 	-0.485	 	-0.089	0.005	1.05E-04	ABCC1,ABCC3,ADIPOQ,APOB,APOE,BMP6,CDKN2AIPNL,CTGF,CYBB,CYP27A1,CYR61,DUSP1,EGR1,FOS,FOSB,HMGCS1,HMOX1,ITGB2,JUNB,LEP,MMP9,MSMO1,MVD,NPC1L1,NR1H3,NR4A1,PLAT,PMVK,PRNP,SLC25A51,SOD1,SPP1,VCAM1	APOE,CEBPA,CTNNB1,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RXRA,SP1,SREBF1,STAT3,TNF,atorvastatin	
P3	 	25-hydroxycholesterol	 	chemical reagent	 	-0.538	 	0.095	-0.895	1.11E-04	ASNS,ATF4,CHAC1,DDIT3,FOS,FOSB,HMGCS1,HMOX1,HSPA5,JUNB,NR4A1,SCD,SREBF1,SREBF2,TRIB3	25-hydroxycholesterol,ETS1,FOS,INSIG1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARGC1A,RELA,SREBF1,SREBF2,STAT3,TP53,cholesterol	
P3	 	ETS2	-1.503	transcription regulator	 	1.690	bias	0.596	 	1.11E-04	BCL2L1,CSF1R,CYP27A1,FGF1,FOS,GSK3B,HMOX1,JUNB,LYZ,MGAT5,MMP9,MSR1,PLAU,SPP1,TIE1	CREB1,CREBBP,CREM,CSF1,Creb,ELK1,ERK1/2,ETS2,HIF1A,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	LEP	-4.629	growth factor	 	-0.539	bias	0.265	-2.312	1.12E-04	ABCB11,ABCC3,ADIPOQ,AKR1C1/AKR1C2,APP,ASS1,BCL2L1,CD14,CD63,CD68,CEBPB,CIDEA,CYBB,CYP4A11,CYR61,DUSP6,EGR1,ESR2,FAS,FGFR2,FOS,GAPDH,GSK3B,HSPA5,IGFBP3,IL1RN,JUNB,KIF3B,LEP,LIPA,MBP,MMP14,MSMO1,MT-CYB,MT-ND1,NPY1R,PCK1,PLAT,PLIN1,PLIN2,PLP1,PRDX1,SCD,SLC16A1,SLC25A5,SLC27A4,SMPD2,SOCS3,SOD1,SPP1,SREBF1,SREBF2,THBS1,THRSP,TNFRSF1A,TSPO,UCP2,VCAM1	AKT1,CEBPA,FOXO1,FOXO3,IGF1,INS,Insulin,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF,TP53	
P3	 	EIF4E	-1.868	translation regulator	Activated	4.922	bias	0.710	 	1.19E-04	ATOX1,BCL2L1,CAPG,CAPZB,CEBPB,CHMP1A,FASTK,GPS2,HIF1A,HMOX1,HRAS,IGFBP4,ILF2,LSM1,LSM4,MPV17,NHP2,NOP10,ODC1,PHB,POP7,PRDX5,RHOG,UBE2A,ZPR1	EIF4E,JUN,RELA,Ras,SP1,STAT3,TP53	
P3	 	halofuginone	 	chemical drug	 	 	 	 	 	1.19E-04	AACS,CPA3,CTGF,CYGB,DKK3,EDNRB,EGR1,EMP1,EPHX1,GDE1,GOT1,HK1,HSPA4,IGFBP3,MMP9,NAB2,NFE2L2,NUPR1,PKM,PLCB4,POR,PPT1,PRELP,SPP1,STEAP3	FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,halofuginone	
P3	 	cigarette smoke	 	chemical toxicant	 	1.822	bias	0.545	 	1.21E-04	AOX1,ATF4,BCL2L1,CCT5,CYP1B1,CYR61,DDIT3,EGR1,FOS,FTL,GCLM,GSTM5,GSTP1,HDAC2,HIF1A,HMOX1,HSPA5,HSPA9,KLF4,LEP,MMP9,MT-ATP6,NFE2L2,NQO1,OAS1,PGD,PRDX1,RAPGEF3,SLC1A4,SQSTM1,SREBF1,TCP1,TREM2,TXNRD1	BACH1,CEBPA,JUN,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,Ras,SP1,STAT3,TNF,TP53,cigarette smoke	
P3	 	GPX1	1.735	enzyme	Inhibited	-2.030	bias	-0.507	 	1.23E-04	CD14,CTGF,CYBB,DUSP4,FAS,GLRX2,MMP9,SOD1,TNFRSF1A,TXN,TXN2,VCAM1	ETS1,FOS,FOXO1,GPX1,HIF1A,JUN,LEP,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TP53,reactive oxygen species	
P3	 	thapsigargin	 	chemical toxicant	Activated	2.052	bias	0.369	0.232	1.25E-04	ADCY1,ADIPOQ,ASNS,ATF4,BCL2L1,CALR,CD83,CEBPB,CHAC1,DDIT3,EGR1,FOS,HIF1A,HMOX1,HSPA5,HSPA9,ITGB2,KLF4,KPNA1,LONP1,MMP9,NFE2L2,NR4A1,PCK2,PRNP,SESN2,THRSP,TPO,VCAM1	CTNNB1,EIF2AK3,FOS,FOXO3,Insulin,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,thapsigargin	
P3	 	GW3965	 	chemical reagent	 	1.187	 	0.136	0.709	1.28E-04	APOE,APP,DGAT2,IL1RN,MMP9,NR1D1,NR1H3,NR5A2,PLIN2,PLTP,SCD,SOCS3,SREBF1,THRSP	CEBPB,CTNNB1,FGF21,FOXO1,GW3965,NFKB1,NFkB (complex),NR3C1,PGR,PPARG,RELA,STAT3,progesterone	
P3	 	HSF1	1.497	transcription regulator	 	0.295	 	0.060	-0.005	1.33E-04	AHSA1,BAG3,BCL2L1,CBX3,CCT3,CCT4,CCT5,CCT7,DNAJA4,FGF1,FKBP4,HMOX1,HSP90AB1,HSPA4,HSPA8,HSPD1,HSPE1,HSPH1,MAPT,MAT2A,MLH1,RAB5C,RARRES3,SERPINH1,SHC1,SLC5A3,STIP1,TCP1,TRAF3,VCAM1	CEBPA,HIF1A,HSF1,HSF2,HTT,Hsp70,NFKB1,NFKBIA,NFkB (complex),RELA,TNF	
P3	 	cerivastatin	 	chemical drug	 	0.042	 	-0.065	0.249	1.35E-04	ASS1,CNP,CTGF,CYP1B1,GNB1,HMGCS1,HMOX1,ITGB2,KLF2,MMP9,NR2F6,PDGFA,PLAT,PLAU,TIE1,TMSB10/TMSB4X,VCAM1	CEBPA,CTNNB1,FOS,JUN,Jnk,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,RELA,Ras,SP1,STAT3,TNF,TP53,cerivastatin	
P3	 	troglitazone	 	chemical drug	 	-0.557	 	0.068	-0.967	1.40E-04	ADIPOQ,ALAS1,ANXA2,BCL2L1,C9orf72,CARS,CCND2,CCND3,CEBPG,CFL1,CHCHD10,COL15A1,COX7A1,CYP2B7P,DDIT3,EGLN3,EGR1,EIF5,ENTPD5,FOS,G0S2,GDF15,HMOX1,HSPA5,KLF4,LEP,ME1,MKI67,MMP9,MRPL47,MSR1,MT-ND1,NNMT,NR1H3,NR4A1,P4HA1,PCK1,PLIN1,PLIN2,PNRC2,SCD,SLC9A1,SORBS1,SPP1,TALDO1,THRSP,TRIB3,TSN,TWF2,UCP2,USP18,VCAM1	CEBPA,CEBPB,D-glucose,FOXO1,HIF1A,Insulin,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,TNF,palmitic acid,troglitazone	
P3	 	CDK5	1.559	kinase	 	1.394	bias	0.312	0.530	1.41E-04	CD14,GLB1,IGFBP3,KCNMA1,MBP,PLP1,PPP1R1B,PSMB5,RALA	AKT1,CDK5,CDK5R1,Creb,FOS,FOXO1,HIF1A,JUN,MTOR,NFkB (complex),NR3C1,NR4A1,RELA,SIRT1,SP1,STAT3,TP53	
P3	 	paclitaxel	 	chemical drug	 	1.457	bias	0.279	0.301	1.49E-04	ALPK3,ANXA5,ARHGEF2,ATF4,BCL2L1,BHLHE41,BTG2,CD53,CTGF,CYP1B1,DDIT3,DUSP10,DUSP4,DUSP6,EGR1,EMP1,ETV5,FAS,FLNA,G0S2,GDF15,GRINA,HIF1A,HLA-A,HSP90AB1,IGFBP3,KIFC3,LCP1,MAP3K1,MMP9,NXPH4,PLAU,PNKD,PRELP,SH2B3,SHB,TFPI,THBS1,TMEM184B,TUBA1B,TYMP,UGCG	CEBPA,ERK,ERK1/2,FGF2,FOXO3,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,TP53,paclitaxel	
P3	 	MAP2K1	1.323	kinase	Activated	2.013	bias	0.585	 	1.54E-04	ABCC1,APOE,BCL2L1,CLDN2,CSTA,CTGF,CTSB,DAB2,DUSP1,DUSP6,ENO1,ETV5,FBXW11,FLNA,FOS,HIF1A,HSPA5,LEP,MBP,MMP14,MMP9,RAB38,RAP2B,RRAGD,SERPINA1,SERPINE2,SIRPA,THBS1,UNC5B	CTNNB1,EGFR,ERK1/2,JUN,MAP2K1,MMP9,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RELA,RNA polymerase II,SP1,STAT3,estrogen receptor	
P3	 	SP600125	 	chemical - kinase inhibitor	 	-0.115	bias	-0.297	1.541	1.55E-04	ABCB11,AKR1C3,APOE,BCL2L1,CD83,CEBPB,COL8A1,CSF1R,CSPG4,CTGF,CXCL16,CYR61,EGR1,FAS,FOS,FOSB,HMOX1,JUNB,LEP,MMP9,NR4A1,P4HA2,PAFAH1B2,PCK2,PRDX1,PTX3,SCD,SGPL1,SOCS3,SPP1,SREBF1,THBS1,VCAM1	Akt,CEBPA,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,SP600125,STAT3,TNF	
P3	 	GCG	-5.346	other	 	-0.305	bias	0.370	-1.753	1.63E-04	ADIPOQ,BCL2L1,BTG2,CEBPB,FOS,FST,GSTP1,HK1,IGFBP4,IVD,ODC1,PCK1,PPP1R3C,SREBF1,SREBF2,VCAM1	CEBPA,CEBPB,D-glucose,FOXO1,FOXO3,GCG,HIF1A,INS,Ins1,Insulin,MYC,NFE2L2,NFkB (complex),PI3K (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3	
P3	 	POR	2.204	enzyme	 	-1.660	bias	-0.278	-0.750	1.63E-04	ABCC3,ACTG1,ALDH1A2,ANXA5,ASNS,ATF5,CPA3,CYB5B,CYP4A11,ELOVL1,ENTPD5,FGF1,GSTM5,HADHB,HIF1A,HLA-A,HMGCS1,HMOX1,HSPH1,MSMO1,MVD,PFKFB3,PGD,PMVK,POR,PRNP,SCD,SDC4,SREBF2,TMEM176A	ARNT,HIF1A,NFKB1,POR,PPARG,STAT3,TP53	
P3	 	NR4A1	-6.107	ligand-dependent nuclear receptor	 	-0.937	 	0.066	-1.180	1.70E-04	ADIPOQ,AKR1C1/AKR1C2,ALDOA,APOB,APOE,CIDEA,CLDN5,COL16A1,COL6A1,CSF1,CXCL12,DDIT3,G0S2,GSTM5,GYS1,HIF1A,HMOX1,LEP,LY6E,MARCKSL1,MAT2A,MMP9,NUCB2,PEBP1,PPP1R3C,SCD,SREBF1,UCP2,VCAM1	Akt,CTNNB1,D-glucose,FOXO1,FOXO3,HIF1A,HMGA1,IRS1,Insulin,JUN,MYC,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,fatty acid	
P3	 	ERBB4	-7.716	kinase	 	1.191	 	0.034	1.058	1.78E-04	ADAM9,BTG2,COL5A2,CXCL12,DDIT3,DUSP1,EGR1,ERBB4,GPAA1,GPC1,HIF1A,HMOX1,IGFBP4,MAP2K3,SERPINE2,SFRP1,SOCS3,THBS1	Akt,CTNNB1,EGFR,ERBB2,ERBB4,ERK,JUN,MYC,NFE2L2,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	GW9662	 	chemical reagent	 	-0.871	 	-0.237	0.125	1.78E-04	ADIPOQ,APP,CD14,CD83,CTGF,EGLN3,ESR2,FADS3,GDF15,HSPA5,KLF4,MID1IP1,NR1D1,PEA15,PLIN2,SREBF1,UCP2,VCAM1	CEBPA,FOXO1,GW9662,IGF1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,fatty acid,rosiglitazone	
P3	 	vancomycin	 	biologic drug	Activated	3.155	bias	0.429	1.354	1.78E-04	AASS,ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GAS5,GSTM3,HMOX1,PSMB10,RTN4,S100A11,SCD,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	bortezomib	 	chemical drug	Activated	2.043	 	0.104	1.472	1.79E-04	ALPL,ATF4,BAG3,BCL2L1,CALR,CCND2,CXCL12,DCAF12,DDIT3,FANCE,FAS,GDF15,HDAC2,HSPA5,HSPE1,IGFBP3,KIT,ODC1,PSMA3,PSMA4,PSMA5,PSMB5,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD3,PSMD7,PSMD8,RAD51C,SAA1,SREBF1,UCHL1,VCAM1	CEBPA,CEBPB,CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT3,TP53,bortezomib	
P3	 	azetidyl-2-carboxylic acid	 	chemical reagent	Activated	2.407	bias	0.710	 	1.80E-04	ASNS,DDIT3,EDEM1,HSPA5,HSPA8,HSPA9	 	
P3	 	GH1	-2.994	growth factor	 	0.471	 	0.183	-0.380	1.86E-04	ABCC1,ACTB,AKR1B1,APOE,ATF4,CCND3,CEBPB,COMT,CYB5B,DDIT3,EGR1,FOS,FTH1,GSTP1,HADHB,IGFBP3,JUNB,MLH1,MT-CYB,MT-ND5,NR2F6,PRDX1,RAD23A,RAD23B,SHMT2,SMARCA4,SOCS3,SOD1,SPP1,SREBF1,TKT,TNFRSF1A,XRCC6	CEBPA,CEBPB,CREBBP,ELK1,ESR1,GH1,IGF1,Ins1,JUN,NFE2L2,NFkB (complex),PI3K (complex),PPARA,PPARG,RELA,SMARCA4,SP1,SPI1,SREBF1,STAT3,TP53	
P3	 	bisphenol A	 	chemical - endogenous non-mammalian	 	1.244	bias	0.496	-0.761	1.91E-04	ADIPOQ,ALAS1,APOB,ATP6AP1,CTGF,CTSD,CXCL12,EGR1,ENO1,ESR2,FOS,HSP90AB1,LAMP2,LEP,MDH2,MMP9,NR4A1,PEBP1,PKM,RPH3A,RPN2,SLC1A5	ADIPOQ,CEBPB,CTNNB1,ERK1/2,ESR1,ESR2,FOXO1,HIF1A,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARA,RELA,SP1,STAT3,beta-estradiol,bisphenol A,progesterone	
P3	 	quercetin	 	chemical drug	 	0.200	 	0.041	0.007	1.93E-04	ACOT1,ARRDC4,BCL2L1,CD63,COMT,CYP4A11,EGR1,FOS,HIF1A,HMOX1,HSPA5,LEP,MKI67,MMP9,NFE2L1,NFE2L2,ODC1,PLAU,POR,PRDX5,SOD1,SOX9,TOLLIP,VCAM1	CTNNB1,ELK1,FOS,FOXO1,HIF1A,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53,nitric oxide,quercetin,reactive oxygen species	
P3	 	CAV1	-1.255	transmembrane receptor	 	-0.147	 	0.137	-0.633	1.93E-04	ADAM17,ADIPOQ,CD14,CSF1R,EGR1,FAS,FOS,HMOX1,HSPA8,LEP,LRP6,NPM1,NQO1,NR4A1,RALA,RPL17,RPS13,SLC20A1,SLC7A2,ST6GALNAC4,TFPI,THBS1,TXNL4A	AKT1,CAV1,CEBPA,CREBBP,Creb,EP300,FOXO1,HMOX1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,NRF1,P38 MAPK,RELA,SP1,STAT3,TNF,TP53	
P3	 	NRG2	1.424	growth factor	 	 	 	 	 	1.95E-04	ARPC4,BIN1,CCND3,CTGF,CYR61,EEF1A1,EGR1,FOSB,HMOX1,JUNB,NR4A1,PDGFA,PFKFB1,PRKACA,SGSH	Akt,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),NRG2,RELA,SP1,STAT3	
P3	 	SIRT1	-1.244	transcription regulator	Inhibited	-3.694	 	0.067	-3.983	1.96E-04	ACTB,ADAMTS5,ADIPOQ,ATXN10,BCL2L1,CCND2,CNR1,CTBP1,EDEM1,EIF2S2,H2AFZ,HMOX1,KIF1A,KLF2,LEP,MAPT,MGAT1,MLH1,MMP9,MT-CO1,MTHFD1L,NR1D1,PCK1,PCK2,POLR1A,PRMT3,RPL13,SEC61A1,SFRP2,SHANK2,SLC7A11,SREBF1,TFPI,UCP2,UQCRFS1	ADIPOQ,AMPK,Akt,FOXO1,FOXO3,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,SIRT1,SP1,SREBF1,SREBF2,STAT3,TP53	
P3	 	ERBB3	-1.738	kinase	 	0.076	 	-0.075	0.386	2.08E-04	ACTB,ADAM9,CCND2,CMA1,COL6A1,CXCL12,DUSP1,EGR1,EIF6,GAS5,HIF1A,HMOX1,MATN2,SFRP1,SLC4A7,SOCS3,THBS1,TNXB	Akt,CTNNB1,EGF,EGFR,ERBB2,ERBB3,ERBB4,JUN,MYC,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	PDX1	-3.535	transcription regulator	 	-1.371	 	0.135	-2.024	2.09E-04	ACTB,ACTG1,AKR1B1,AKR7A2,ANXA2,ARRDC4,ATG9A,ATP5H,CSNK2B,DUSP6,EGR1,FGF1,FH,GCLM,GNG12,GOT1,GRN,HK1,IGFBP3,JUNB,MAPT,MT-ND1,NDUFB9,NQO1,NR5A2,NUPR1,SLC6A6,SPP1,TIPRL	CEBPA,CEBPB,Ins1,Insulin,PDX1,PPARA,PPARG,RELA,RNA polymerase II,SP1,SREBF1,TP53	
P3	 	fluticasone	 	chemical drug	 	-1.271	 	0.017	-1.361	2.09E-04	ADAM9,C1QB,CD4,CD83,CES1,CHI3L1,EMP1,FKBP5,FSCN1,GJB2,IL1RN,IRF8,MMP9,OLFML2B,PLAU,PLIN2,RARRES3,RNASE1,SDC4,SERPINA1,SLC2A5,SPP1,SRPX,TBC1D16,TFPI,THBS1,TPM3,VSIG4,WARS	EP300,FOXO1,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TP53,fluticasone	
P3	 	acetaminophen	 	chemical drug	Activated	2.856	bias	0.268	1.542	2.09E-04	ABCB11,ABCC1,ABCC3,ACTB,ACTG1,BTG2,CES1,CYP4A11,DDIT3,FAS,GLUL,GSTP1,HIF1A,HMGCS1,HMOX1,HSPA5,HSPD1,IGFBP3,ME1,NQO1,ODC1,PRDX1,SOCS3,TUBB,TXN,VCAM1	BACH1,CEBPA,CTNNB1,FOS,IL1B,JUN,Jnk,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53,acetaminophen,hydrogen peroxide	
P3	 	ferric chloride	 	chemical toxicant	 	1.293	bias	0.710	 	2.10E-04	FTH1,FTL,PLAT,PLAU	 	
P3	 	RTN4	2.250	other	 	-1.362	 	-0.032	-1.247	2.20E-04	ACTR1A,APP,ARHGDIA,CFL1,FGF1,GNG2,MAPRE3,MBP,NQO1,PEA15,RTN4,YWHAB,YWHAG	 	
P3	 	triamcinolone acetonide	 	chemical drug	 	-1.309	 	0.021	-1.427	2.23E-04	ANOS1,ARL4C,ATP10A,BMP6,BTG2,CAPG,CBX4,DDIT3,DGKE,DUSP1,DUSP10,EFS,EGR1,FGFR2,FKBP5,FOS,IGFBP3,IGFBP4,JUNB,MEGF9,MT1M,MYOC,PCDH19,PLAU,SAA1,SCD,SFRP2,SLC16A1,SLC4A7,SPP1,STC2,TGFB2,ZBTB16	CREBBP,CTNNB1,EP300,FOS,FOXO3,HIF1A,JUN,Jnk,NFKB1,NFkB (complex),NR3C1,RELA,RNA polymerase II,STAT3,TP53,Vegf,triamcinolone acetonide	
P3	 	AGPAT2	1.582	enzyme	 	-1.134	 	-0.042	-1.023	2.29E-04	ADIPOQ,CEBPB,DGKG,LEP,PLD3,PLIN1,SCD	 	
P3	 	prednisolone	 	chemical drug	Inhibited	-3.917	bias	-0.364	-1.770	2.33E-04	APOE,APP,ARSA,ATG9A,BAG3,BCL2L1,CTSB,CTSS,CYGB,DAD1,DUSP1,DUSP10,FAS,FKBP5,GAA,GABARAP,GM2A,HSPA8,LOC102724428/SIK1,MRPS16,NQO2,PARK7,PCK1,PLAT,PRDX1,PRNP,RARRES3,SLC29A3,SLC41A3,SOD1,SPP1,SQSTM1,TMEM43,TPO,ZBTB16	EP300,FOS,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT3,TP53,prednisolone	
P3	 	trichostatin A	 	chemical drug	 	0.447	bias	0.401	-2.329	2.51E-04	ACTB,ADAMTS5,ADCY1,ALPL,APOE,ATP5I,BCL2L1,CA12,CCND2,CD14,CD28,CPA3,CTPS1,CYBB,CYP1B1,CYP4B1,DPM2,DUSP1,ESR2,FAS,FOS,GSTM4,HDAC2,HIF1A,HMGCS1,HSD11B2,IGFBP3,IL10RA,IRF8,KIT,LAGE3,LAMA2,LGMN,LIMA1,LMX1A,LRP8,MAF,MAT2A,MLH1,MMP9,NR1H3,PAX5,PHB,PLAU,PLCE1,PRNP,RAD23B,RBBP8,RERG,RPL13,SCAMP2,SELT,SFRP1,SGPL1,SHC1,SIAH2,SMARCA4,SQSTM1,SREBF1,SREBF2,STT3A,THBS1,THSD4,TMSB10/TMSB4X,TNFRSF1A,TOP2A,TP63,TRAF3,UBIAD1,VCAM1,WHSC1	CDKN2A,CSF2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,TP53,decitabine,trichostatin A	
P3	 	EIF2AK4	1.159	kinase	Activated	2.395	bias	0.558	 	2.69E-04	ASNS,ATF4,CHAC1,DDIT3,EGR1,MBP,PCK2,PLP1,PSAT1	 	
P3	 	Cdc42	 	enzyme	Activated	2.333	 	0.178	1.801	2.81E-04	ATP6V1A,CSF1,CTSA,CTSB,CTSD,CTSS,FAS,FLNA,GSK3B,LAMP2	Akt,Cdc42,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3	
P3	 	GATA1	-3.134	transcription regulator	 	-1.689	bias	0.304	-3.090	2.85E-04	ACTN1,ALOX5AP,BCL2L1,BMP6,BTG2,BZW2,CCND2,CCND3,CDK6,CMA1,CPA3,CYBB,EGR1,FHL1,FOSB,FYB,HNRNPAB,HSPA9,JUNB,KIT,LYZ,MBP,MECOM,NAB2,NHP2,PLEK,PLXNA1,RPS11,SPTB,SRM,ST3GAL6,TFRC	CEBPB,CTNNB1,FOXO1,GATA1,IL13,IRF8,JUN,MITF,NFKB1,NFkB (complex),RELA,RUNX1,SPI1,STAT3,TP53	
P3	 	actinomycin D	 	chemical drug	 	-1.814	bias	-0.480	0.894	2.91E-04	ACTB,AGFG1,APP,ASS1,CD28,CTGF,CYR61,DUSP1,DUSP4,EGLN3,FAS,FLNA,FOS,FTH1,GAPDH,GSTM5,GSTP1,HIF1A,HK1,HMOX1,IGFBP4,NPM1,PFKFB3,PLAU,PTX3,RRM2B,SDC3,SLC20A1,SLC30A1,SOCS3,SPP1,TACR1,THRA	CEBPA,CTNNB1,FOXO3,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,Vegf,actinomycin D	
P3	 	wortmannin	 	chemical - kinase inhibitor	Inhibited	-2.422	bias	-0.353	-0.581	2.93E-04	BCL2L1,CCND2,CCND3,CD14,CIDEA,CSF1,CTGF,CXCL16,DDIT3,EGR1,FOS,GSTP1,HIF1A,HMOX1,IRF8,LEP,MAF,MMP14,MMP9,MSR1,NFE2L2,NR4A1,OGT,P4HA1,PLAU,SOCS3,SREBF1,TFRC,TYMP,VCAM1	Akt,CEBPA,CTNNB1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TNF,wortmannin	
P3	 	FOXO3	-1.785	transcription regulator	 	-1.163	bias	0.300	-2.538	2.95E-04	CCND2,CTGF,CYR61,DDIT3,DOK5,EGR1,FGFR2,FOS,FOSB,GLUL,GSTM5,IARS,IMPDH2,JUNB,MKI67,MMP9,PLAU,PRDX5,PRNP,SCO2,SLC1A4,SLC7A1,SOD1,SREBF2,TGFB2,TNFRSF1A,TXN2,UCP2	AKT1,CTNNB1,FOXO1,FOXO3,JUN,MXI1,MYC,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,SP1,STAT3,TP53,Vegf	
P3	 	Mek	 	group	 	1.051	bias	0.326	-0.551	3.09E-04	APOE,BCL2L1,BMF,CCND2,CCND3,CLDN2,CSF1R,CTGF,DDX21,DUSP6,EGR1,ETV5,FOS,GNL3,LEP,LRP8,MMP14,MMP9,NR1H3,NR4A1,PPAT,SNCG,SORL1,SPRY4,THBS1,TOP2A,UNG	Akt,CTNNB1,ERK,FOS,JUN,Jnk,MAP2K1,MYC,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3	
P3	 	LAMA2	-2.774	other	 	-1.478	 	0.065	-1.618	3.12E-04	CLDN5,DES,LAMA2,MBP,MMP9,PAG1	 	
P3	 	TCR	 	complex	Activated	2.398	bias	0.468	-0.069	3.17E-04	BCAT1,BCL2L1,BIN1,BSG,CCND3,CD28,CD4,CTSB,DKC1,EBNA1BP2,EGR1,ETV5,F5,FAS,FLNA,FOS,GNPDA1,HIF1A,HSPA5,HSPD1,JUNB,KLF2,LIPA,LPIN2,LSM3,MAF,NHP2,NIP7,NME1,NR4A1,OAS1,ODC1,PTPRC,RPL13A,SDCBP,SIAH2,SNRPD3,SOCS3,SPP1,TNFRSF12A,TNFRSF1A,TRAF3	CEBPA,CSF2,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,Pkc(s),RELA,RNA polymerase II,SP1,STAT3,STAT5B,TCR,TNF,TP53	
P3	 	CD40LG	-1.030	cytokine	Activated	2.847	bias	0.573	 	3.36E-04	ADAM17,ALCAM,ALG3,ANXA7,APRT,ATF5,BCL2L1,BTG3,CBX3,CCND3,CD63,CD83,CDK6,CLIP1,CLUH,CSF1,CTGF,CYP1B1,DUSP1,DUSP4,EGR1,EIF2S1,FAS,FOS,FOSB,FSCN1,G0S2,HIF1A,IL10RA,ITPA,JUNB,MAP2K3,MARCKSL1,MMP14,NINJ1,PLAU,PLEK,PMVK,PREPL,PSMB10,PSME1,PSMG1,PVR,TFRC,TNPO1,TRAF3,TREM2,TUBB,TYMP,VCAM1,XRCC6	CD40LG,CEBPA,FAS,IL1B,IL4,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	Pro-inflammatory Cytokine	 	group	 	1.526	bias	0.543	 	3.36E-04	AKR1B1,APOE,ASS1,GLUL,HMOX1,HSPA5,LGALS9,MMP9,NFE2L2,NR4A1,S100A1,SDC4,SOCS3,VCAM1	CTNNB1,FOXO3,Insulin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,Pro-inflammatory Cytokine,RELA,SP1,SREBF1,SREBF2,STAT3,Vegf,cholesterol	
P3	 	ouabain	 	chemical drug	 	0.742	bias	0.292	-0.215	3.43E-04	ACTB,ANXA5,BCL2L1,DDIT3,FOS,HIF1A,HSPA5,HSPA8,HSPA9,PHB,YWHAG	CTNNB1,EDN1,EGFR,ELK1,FOXO1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,estrogen receptor,ouabain,reactive oxygen species	
P3	 	ADRB1	-1.163	g-protein coupled receptor	 	0.246	 	0.237	-0.278	3.48E-04	APP,DDIT3,HSPA5,IRAK1,LEP,SLC9A1,THBS1	ADRB1,CEBPB,CREB1,CREBBP,CTNNB1,Creb,EGFR,EP300,FOS,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,cyclic AMP,estrogen receptor,isoproterenol	
P3	 	IREB2	1.364	translation regulator	 	-1.264	bias	-0.394	-0.396	3.50E-04	ACO2,APP,FTH1,FTL,TFRC	HTT,IREB2,NFE2L2,VHL,iron	
P3	 	targinine	 	chemical drug	 	-0.366	 	-0.024	-0.296	3.62E-04	ADIPOQ,FAS,FOS,HMOX1,ITGB2,MMP9,PRDX1,SOD1,VCAM1	CEBPA,D-glucose,ELK1,FOXO1,HIF1A,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TNF,nitric oxide,targinine	
P3	 	RB1	1.302	transcription regulator	Activated	4.568	 	0.175	3.540	3.69E-04	ACO2,ACTB,ALPL,ATP6V1F,BTG3,CBX5,COA3,COX14,COX17,COX4I1,CTGF,EGR1,FAS,FOS,FST,GHITM,GPS2,GRPEL1,H1F0,HACD3,HRAS,ICT1,KIT,LACTB,MAF,MAP2K3,MECR,MRPL17,MRPL55,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFS4,NME1,PARK7,PGD,PTX3,SDHC,SRPRA,TGFB2,TOMM22,TOMM6,TPO,TUBG1,TXN2,UQCRC1,UQCRFS1,UQCRQ,VDAC1	Akt,E2F1,ERK,ESR1,FOXO1,FOXO3,JUN,MXI1,MYC,NFKB1,NFkB (complex),RB1,RELA,RNA polymerase II,SP1,STAT3,TP53,VEGFA	
P3	 	Ifn gamma	 	complex	Activated	2.534	bias	0.411	0.921	3.73E-04	BCL2L1,CHI3L1,CSE1L,CXCL16,CYBB,FAS,GBP1,IGFBP4,IRF8,LGALS9,MAP4K4,MMP9,PCDH7,PCK1,PSME1,SOCS3,TGFB2,VSIG4	CEBPA,CEBPB,IFNG,IRF8,Ifn gamma,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,RNA polymerase II,SPI1,STAT3,TNF,TP53	
P3	 	dinoprost	 	chemical - endogenous mammalian	 	0.528	bias	0.257	-0.382	3.73E-04	AKR1C1/AKR1C2,CCND2,FOS,GSTP1,HSD11B2,HSPA4,LIPA,MMP9,NR4A1,POR,PTGFR,PTX3,SPP1,THBS1,THRSP,YWHAG	Akt,CEBPA,CEBPB,Creb,ELK1,JUN,Mek,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PI3K (complex),RELA,SP1,STAT3,TNF,TP53,dinoprost,progesterone	
P3	 	estrogen	 	chemical drug	 	1.805	bias	0.467	-0.701	3.76E-04	ALDH1B1,AP3D1,APOB,APOE,CFTR,COL15A1,COMT,CTGF,CTSD,CXCL12,CYBB,CYR61,DUSP1,EGR1,ESR2,FAS,FOS,FTH1,GJB2,HIF1A,HSPH1,IGFBP4,IGFBP6,JUNB,LTF,MVD,NDUFV3,NME1,NR4A1,PLAT,PTX3,RET,SERPINE2,SOD1,SPP1,SRM,TGFB2,TOP2A,TRIM16,UNG	CEBPA,HIF1A,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TGFB1,TNF,estrogen	
P3	 	PRNP	3.039	other	 	1.083	 	0.047	0.921	3.91E-04	APOE,APP,ATF4,CTSD,DAB2,EGR1,EIF2S1,FST,HSPA5,HSPA8,HSPA9,LAMP2,PRNP,SOX9,TCF7	APP,CEBPA,CEBPB,CREBBP,HIF1A,IGF1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PRNP,RELA,SP1,SREBF1,SREBF2,STAT3,TP53,cholesterol,cyclic AMP	
P3	 	LIPE	1.161	enzyme	 	-0.579	 	0.161	-1.029	3.97E-04	ADIPOQ,CEBPB,EGR1,FKBP5,FOS,G0S2,GAPDH,MAPKAPK2,MAPT,MSR1,NR4A1,PCK1,PFKFB1,PLIN2,POLR2K,SCD,SDC4,SREBF1,THRSP,TKT,TWF2,YWHAG	AKT1,CEBPA,CEBPB,FOXO1,Ins1,JUN,LDL,LEP,LIPE,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,TP53,fatty acid	
P3	 	ARNT	1.216	transcription regulator	Activated	2.902	bias	0.561	 	4.00E-04	ADAM17,ALDOA,ALDOC,ATP5G1,BHLHE41,CCND2,CTSD,CYP1B1,DEGS1,EIF6,ENO1,GAPDH,HIF1A,ITGAV,LEP,NDUFS4,NQO1,OAZ1,PCK2,SIM1,TFRC	AHR,ARNT,CEBPB,CREBBP,ELK1,ESR1,ESR2,HIF1A,MYC,NFKB1,NFkB (complex),PPARG,RELA,SP1,STAT3,TP53,VHL	
P3	 	ursodeoxycholic acid	 	chemical - endogenous mammalian	 	0.344	 	0.189	-0.326	4.02E-04	ABCB11,ABCC3,BCL2L1,CTGF,CYP27A1,CYP4A11,DDIT3,GCLM,MAF,MAFG,PDGFA,SPP1,SREBF1,TGFB2	BACH1,ELK1,FOXO1,FOXO3,JUN,KEAP1,MAP2K1/2,NFE2L2,NFKB1,NFkB (complex),PRKCA,RELA,SREBF1,SREBF2,STAT3,TP53,cholesterol,nitric oxide,ursodeoxycholic acid	
P3	 	STAT5B	-1.052	transcription regulator	 	-0.076	 	0.178	-0.917	4.17E-04	AKR1C1/AKR1C2,AKR1C3,BCL2L1,CCND2,CCND3,CDK6,CIDEA,COX7A1,DGAT2,ESR2,FAS,FOS,HEXA,LEP,MAF,ME1,MYH1,PAX5,PPP1R3C,SCD,SH3RF3,SOCS3,THRSP,TNFRSF1A,TPM3,TRAF3,WARS	AKT1,CEBPA,FOXO1,IGF1,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PI3K (complex),RELA,SP1,STAT3,STAT5B,TNF,TP53	
P3	 	RELA	1.474	transcription regulator	 	1.811	bias	0.489	-1.021	4.18E-04	ADAMTS5,ALCAM,AP1B1,APOE,APP,BCL2L1,BTG2,CD14,CEBPB,CFTR,CHI3L1,CTGF,CTSB,CYBB,DDIT3,DUSP1,EGR1,ERAP2,FAS,FOS,FSCN1,GBP1,GDF15,HIF1A,HMOX1,IL1RN,JUNB,KIT,MAT2A,MMP9,MT-CYB,NFE2L2,NR4A1,PCK1,PLAU,PSMB10,PTX3,SAA1,SAA2,SDC4,SERPINE2,SLC2A5,SOX9,SREBF1,SREBF2,STIM1,TACR1,TP63,TPO,VCAM1	CEBPA,HIF1A,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT3,TNF,TP53	
P3	 	RETN	-4.088	other	 	-0.044	bias	0.403	-1.292	4.31E-04	CTGF,FOS,HMOX1,MMP14,PLAT,SCD,SOCS3,SPP1,SREBF1,TRAF3,VCAM1	Akt,CEBPA,IL6,JUN,LDL,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RETN,SP1,STAT3,STAT5B,TNF	
P3	 	RUNX1	 	transcription regulator	 	0.834	bias	0.309	-0.376	4.38E-04	ALCAM,BTG2,CCND3,CD4,CD53,CHI3L1,CPA3,CSF1,CSF1R,CTSG,FAS,FSCN1,IGFBP3,MECOM,MYL9,NCAM1,PCDH7,SH3GL1,SLC24A3,SPP1,TPSAB1/TPSB2,UGCG,ZBTB16	CEBPA,CEBPB,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARG,RELA,RUNX1,SMARCA4,SP1,SPI1,STAT3,TP53,progesterone	
P3	 	IL1A	-4.555	cytokine	 	1.401	bias	0.467	-1.153	4.47E-04	ADAMTS5,ALDH3A2,APP,BCL2L1,CD83,CSF1,CXCL12,CYR61,F2RL3,FAS,FOS,FTH1,GBP1,HMOX1,HSD11B2,IL1RN,IRAK1,ITGAV,KIT,LEP,LGALS9,MCAM,MMP14,MMP9,NFKBIZ,PDGFA,PLAU,PTX3,SAA1,SAA2,SERPINA1,SPP1,VCAM1	CEBPA,HIF1A,IL1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	CEBPE	-2.938	transcription regulator	 	0.484	bias	0.336	-0.507	4.68E-04	ALOX5AP,BCL2L1,CCND2,CD14,CDK6,CEBPB,CSF1R,IL1RN,LTF,LYZ,MBP,MMP9	CEBPE,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P3	 	trans-hydroxytamoxifen	 	chemical drug	 	-0.143	 	-0.164	0.606	5.08E-04	ALDH4A1,CBX6,CXCL12,CYP1B1,DUSP1,DUSP4,EPB41L3,GSTP1,IFI30,IGFBP4,LHFPL2,LITAF,MAPT,MATN2,PPP1R3C,SIAH2,SLC39A6,SNCG,STXBP1,TGFB2,TOP2A	ESR1,ESR2,MYC,SP1,STAT3,TP53,trans-hydroxytamoxifen	
P3	 	PRKAA2	-1.028	kinase	 	-1.673	bias	-0.308	-0.377	5.09E-04	ALAS1,CIDEA,COX4I1,CXCL12,CYBB,DDIT3,DUSP4,EGR1,FGFR2,HIF1A,HIGD1A,HSPA5,IGFBP4,LEP,LMO4,MMP9,MT-CO1,SLC16A1,SORL1,SREBF1	AMPK,Akt,FOXO3,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,PPARGC1A,PRKAA2,RELA,SIRT1,SP1,SREBF1,STAT3,TP53,VEGFA,fatty acid	
P3	 	CETP	1.353	enzyme	 	-0.547	 	-0.237	0.068	5.13E-04	APOB,APOE,DDIT3,HSPA5,PLIN1,PLIN2,SREBF1	CETP,Insulin,LDL,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,SREBF2,cholesterol	
P3	 	RHOJ	1.162	enzyme	 	 	 	 	 	5.13E-04	ACTG1,ADIPOQ,ANXA1,CCNI,CNBP,PLAT,PPP2R1A	 	
P3	 	RAF1	1.129	kinase	 	1.880	bias	0.619	 	5.23E-04	ANXA1,CDC42EP1,CDON,CSTA,DUSP4,DUSP6,EGR1,EMP1,FAS,FBXW11,FOS,GRN,HIF1A,HNRNPAB,HSD11B2,IGFBP3,MGAT5,MKI67,MMP9,MT1M,NINJ1,PCK1,PHLDA2,PLAT,PLAU,RAN,RET,RPS2,SNRPD1,ST6GALNAC2,TUBB2A,TUBG1	CEBPB,CTNNB1,FOXO1,HIF1A,HRAS,IKBKB,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RAF1,RELA,SP1,STAT3,TP53	
P3	 	HNRNPA2B1	1.210	other	 	 	 	 	 	5.27E-04	ABCC6,ANXA7,CA12,DCLK1,FHL1,FSCN1,GDF15,HYAL1,LPAR1,MOCOS,NR2F1,NTRK3,OAS1,P4HA1,PEG10,PKM,PLCB4,PLOD2,ROR1,SEMA3B,SERPINA1,SETBP1,SRPX,TGFB2	 	
P3	 	kainic acid	 	chemical toxicant	 	-0.753	bias	0.482	-2.959	5.27E-04	APOE,APP,ATF4,BCL2L1,BTG2,CEBPB,CLTC,CNR1,CSF1R,CSRNP1,DUSP1,EGR1,ERBB4,FOS,FOSB,HYOU1,JUNB,MMP9,NCAM1,NR4A1,ODC1,RET,SLC16A1,SPP1	CREB1,CREBBP,CREM,Creb,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),NGF,Pkc(s),RELA,RNA polymerase II,STAT3,TP53,kainic acid	
P3	 	2-amino-3-phosphonopropionic acid	 	chemical - endogenous mammalian	 	 	 	 	 	5.50E-04	EGR1,FOS,JUNB	2-amino-3-phosphonopropionic acid,JUN,NFKB1,NFkB (complex),Pkc(s),RELA,STAT3	
P3	 	CIDEB	1.292	other	 	 	 	 	 	5.50E-04	ADIPOQ,LEP,PLIN2	 	
P3	 	FTMT	-2.340	enzyme	 	 	 	 	 	5.50E-04	FTH1,FTL,TFRC	 	
P3	 	Fascin	 	group	 	 	 	 	 	5.50E-04	CTGF,CYR61,MMP9	Akt,CTNNB1,Fascin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TCF7L2,TP53	
P3	 	atipamezole	 	chemical drug	 	 	 	 	 	5.50E-04	EGR1,FOS,JUNB	 	
P3	 	alitretinoin	 	chemical drug	 	1.712	bias	0.321	0.208	5.60E-04	ABCB11,ABCC3,ANXA5,APP,BCL2L1,CCND3,CD14,CD83,CIDEA,COX4I1,CPM,CYCS,DHRS9,DUSP1,FOLR2,FOS,LTF,MKI67,MMP9,PLAU,PLTP,SCD,SPP1,SREBF1,WNT5B	FOS,IL1B,IL6,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,THRB,TP53,alitretinoin	
P3	 	cadmium chloride	 	chemical toxicant	Activated	2.063	bias	0.331	1.094	5.71E-04	ANXA5,ATF4,DDIT3,FOS,HMOX1,HSPA13,HSPA5,IGFBP6,LPAR1,NFE2L2,PLAU,TXN	BACH1,ERK,ESR1,ESR2,FOS,HIF1A,JUN,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,beta-estradiol,cadmium chloride	
P3	 	SRC	1.881	kinase	 	0.774	bias	0.324	-0.598	5.71E-04	BCL2L1,CCND2,CDON,CTSB,DUSP1,ENO1,FOS,GBP1,HIF1A,HMOX1,LAMP2,MMP9,NFE2L2,NQO1,NQO2,PLAU,PRKCE,SIRPA,SLC4A7,SPP1,VCAM1	Akt,CTNNB1,ERK1/2,ETS1,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PIK3R1,RELA,SP1,SRC,STAT3,TP53	
P3	 	6,7-dinitroquinoxaline-2,3-dione	 	chemical reagent	 	-1.732	bias	0.710	 	5.90E-04	EGR1,FOS,FOSB,JUNB	5-hydroxytryptamine,6,7-dinitroquinoxaline-2,3-dione,Creb,FOS,FOXO3,GNRH1,JUN,NFKB1,NFKBIA,NFkB (complex)	
P3	 	YES1	1.074	kinase	 	-1.961	bias	-0.710	 	5.90E-04	HMOX1,NFE2L2,NQO1,NQO2	AKT1,BACH1,CTNNB1,FOS,FOXO1,Jnk,KEAP1,NFE2L2,NFKB1,NFkB (complex),NR4A1,RELA,SP1,STAT3,TP53,YES1	
P3	 	propofol	 	chemical drug	 	-1.782	bias	-0.473	-0.470	5.94E-04	ANXA1,BCL2L1,CD14,CYBB,EGR1,FOS,HMOX1,MMP9,SOD1,THBS1	Akt,CTNNB1,D-glucose,ERK,FOS,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT3,propofol	
P3	 	Jnk	 	group	 	0.548	bias	0.506	 	6.04E-04	ALDH1A2,ANXA5,APP,BCL2L1,BMF,CD209,CD83,CLDN2,CTGF,CXCL12,DDIT3,DUSP1,EGR1,FAS,FOS,FOSB,GDF15,HMOX1,HSPA5,MMP14,MMP9,NFE2L2,NQO1,NR4A1,PLAT,PLAU,SESN2,SOCS3,TNFRSF12A,VCAM1	CEBPA,CEBPB,IFNG,IL1B,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	dibutyl phthalate	 	chemical toxicant	 	0.080	 	0.154	-0.349	6.11E-04	CYP4A11,FOS,FST,JUNB,NFE2L2,POR,SPP1,SREBF2	AHR,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,dibutyl phthalate	
P3	 	lysophosphatidic acid	 	chemical - other	 	0.286	bias	0.510	 	6.21E-04	CSF1,CTGF,CYR61,DUSP1,EGR1,FKBP5,FOS,GRN,HIF1A,HYOU1,JUNB,LRP6,MMP9,PCK1,PFKFB1,PLAU,RALA	ERK1/2,HRAS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,TP53,lysophosphatidic acid	
P3	 	HSF2	-1.405	transcription regulator	Activated	2.804	bias	0.372	1.761	6.27E-04	CCT3,CCT4,CCT5,CCT7,HIF1A,HSPA4,HSPH1,TCP1,TXN	 	
P3	 	NFE2L1	1.695	transcription regulator	 	1.673	bias	0.516	 	6.27E-04	CYP4A11,GCLM,GSTP1,HMOX1,LEP,NQO1,PSMB5,PSMB6,PSMB7	 	
P3	 	Alpha catenin	 	group	 	-1.524	bias	-0.685	 	6.41E-04	ADAMTS5,BCL2L1,C1QTNF3,CDH11,COL15A1,COL5A2,COL6A1,CTSB,CXCL12,IGFBP4,IGFBP6,LAMA2,LYZ,MMP9,NFKBIZ,PLAU,PTX3,SAA1,SOCS3,TNFRSF12A,VCAM1	Alpha catenin,CTNNB1,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TCF7L2,TP53	
P3	 	JAK2	-1.167	kinase	 	-0.596	bias	0.585	 	6.41E-04	ACTB,ACTN1,AKR1C3,BCL2L1,CCND2,CYBB,DCXR,EGR1,F5,FOS,GCNT2,LY6E,MYL12A,NDN,ODC1,PFN1,PHLDA3,SOCS3,SPTB,THBS1,XIST	ERK,ERK1/2,GATA1,IRF8,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT3	
P3	 	NFkB (complex)	 	complex	Activated	4.189	bias	0.633	 	6.41E-04	ADRA2A,ALDH1B1,APOE,APP,B3GNT5,BCL2L1,CAMK2D,CAPNS1,CCND2,CD83,CEBPB,CFTR,CSF1,CTGF,CXCL12,CYBB,CYR61,DAD1,DDIT3,DOK5,DVL3,EDNRB,EGR1,ERAP2,FAS,FGF1,FOS,FST,FTH1,G0S2,GDF15,HIF1A,HLA-A,HMOX1,HSPA9,IL10RA,IL1RN,ITGAV,JUNB,KCND3,KIT,LAMP2,LITAF,MMP9,NCAM1,NFKBIZ,NR1D1,ODC1,PEA15,PLAU,PPIF,PRKACA,PTX3,SAA1,SDC4,SLC12A7,SLC2A5,SLC2A6,SLC7A1,SLC7A5,SOCS3,SPP1,STIM1,TACR1,TFRC,TNFRSF1A,TOLLIP,TPO,TRAF3,TRIB3,VCAM1,XRCC6	CEBPA,CREBBP,HIF1A,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	TFAP2A	-2.860	transcription regulator	 	-0.545	 	-0.094	-0.247	6.41E-04	ALCAM,ANXA1,APOE,BCL2L1,DCLK1,FASTK,GEM,KLF4,LIPA,PAG1,PLAU,POR,PRDX1,PSAP,RPLP0,RPS5,SESN3,TPM3	CEBPB,CREBBP,CTNNB1,ELK1,ESR1,JUN,NFkB (complex),SP1,STAT3,TCF7L2,TFAP2A,TP53	
P3	 	EZH2	2.042	transcription regulator	 	-1.461	 	-0.021	-1.369	6.45E-04	ACTB,ALOX5AP,ALPL,CCND2,CCND3,CDK6,CNR1,CRISPLD2,CTNNA1,CYP1B1,EGR1,GDF15,GPR26,GSTM4,HOXA10,HOXA6,HOXA7,HOXB5,HSD11B2,IGFBP3,IL10RA,KLF4,MAL2,MLH1,MMP9,NLK,RARRES3,RPL13,SAA1,SAA2,SCAMP2,SELT,SERPINA1,SFRP2,SGPL1,SLC7A11,SOX17,STT3A	CEBPB,CTNNB1,EZH2,FOXO1,NFKB1,RELA,STAT3	
P3	 	THRB	1.140	ligand-dependent nuclear receptor	 	1.262	 	0.209	0.347	6.47E-04	ATP5L,BTG2,CCND2,CCND3,CDK6,COX7A1,CTBP1,CTSD,DAD1,FOS,HIF1A,LYZ,MBP,ME1,NME1,NR1H3,NR4A1,NR5A2,PCK1,PGD,PHYH,PLIN1,POR,SFRP1,SFRP2,SREBF1,SREBF2,THRSP,WNT5B	AKT1,Akt,CEBPB,FOXO1,JUN,L-triiodothyronine,NCOR1,NFE2L2,NFkB (complex),NR4A1,PI3K (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3,THRB,TP53	
P3	 	NMNAT1	-1.529	enzyme	 	1.095	 	0.237	0.577	6.53E-04	ATXN10,NPY1R,PEG10,TFPI,TGFB2	FOXO1,NMNAT1,PPARG,PPARGC1A,SIRT1,SREBF1,STAT3	
P3	 	calmidazolium	 	chemical drug	 	-0.600	bias	-0.284	0.025	6.53E-04	EGR1,FOS,NCAM1,SOX9,VCAM1	CEBPB,CREBBP,EGF,FOS,JUN,NFKB1,NFkB (complex),RELA,Ras,SP1,SRC,STAT3,TP53,calmidazolium,cyclic AMP	
P3	 	pCPT-cAMP	 	chemical - kinase inhibitor	 	-1.427	bias	0.568	 	6.53E-04	APP,EGR1,FOS,JUNB,NR4A1	 	
P3	 	carbon tetrachloride	 	chemical toxicant	 	0.605	bias	0.450	-1.705	6.66E-04	ABCC1,AOX1,APOB,APOE,ASS1,BCL2L1,CNR1,CTGF,DDIT3,DES,DUSP1,FKBP1A,FOS,GDF15,GSTP1,HMOX1,HSPD1,IGFBP6,ITGA8,JUNB,ME1,MMP9,NQO1,NR4A1,ODC1,PDGFA,PRNP,SPP1,TGFB2,TNFRSF12A,VCAM1	CEBPA,CEBPB,CREB1,CTNNB1,FOS,FOXO1,FOXO3,IFNG,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PDGF BB,RELA,STAT3,TNF,TP53,carbon tetrachloride	
P3	 	benzene	 	chemical toxicant	 	0.277	 	0.073	0.013	6.90E-04	ACVR1C,ATF5,BCL2L1,CD63,CDK6,EGR1,IGFBP3,MAPKAPK2,MTPN,NR2F6,RTN4,SLC16A1,TNFRSF1A	 	
P3	 	trichloroethylene	 	chemical toxicant	 	0.277	 	0.073	0.013	6.90E-04	ACVR1C,ATF5,BCL2L1,CD63,CDK6,EGR1,IGFBP3,MAPKAPK2,MTPN,NR2F6,RTN4,SLC16A1,TNFRSF1A	 	
P3	 	BRAF	-1.018	kinase	 	0.036	bias	0.331	-0.688	6.91E-04	BMF,CEBPB,CSF1,CSF1R,DUSP4,EGR1,HIF1A,MMP14,MMP9,SERPINE2,THBS1,TPO	Akt,BRAF,CTNNB1,Creb,EGFR,ELK1,JUN,MAP2K1,MYC,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	PAX3	2.867	transcription regulator	 	 	 	 	 	7.17E-04	ALDH3A2,ANOS1,ANXA1,APP,ASNS,ASS1,BCL2L1,CD151,CLDN5,CNR1,CTSA,CYP1B1,EIF2S1,FHL1,FKBP1A,G0S2,GLB1,GSTM5,ID4,MCAM,MMP9,NNMT,PEA15,PPIB,PPP1R2,PSME1,RET,SREBF1,TGFB2,YARS	MYC,NFKBIA,PAX3,RELA,SP1,STAT3,TP53	
P3	 	11,12-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.947	bias	0.284	-2.680	7.33E-04	ADIPOQ,CYP4A11,DUSP1,MMP9,NME1,PLAT,VCAM1	11,12-epoxyeicosatrienoic acid,ATF4,Akt,CEBPA,E2F1,FOXO1,Insulin,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SP1,SREBF1,STAT3	
P3	 	DOT1L	1.350	phosphatase	 	 	 	 	 	7.33E-04	HOXA10,PPIA,RPL19,RPL41,RPLP0,RPS2,TUBA1C	 	
P3	 	peoniflorin	 	chemical drug	 	-0.562	 	0.142	-0.931	7.33E-04	COX5A,ENO1,HMOX1,PPIF,PPP1R1B,PSMB7,TUBB	 	
P3	 	4-phenylbutyric acid	 	chemical - endogenous mammalian	 	-1.379	 	0.063	-1.615	7.36E-04	CALR,CNP,DDIT3,EIF2S2,EPHX1,HIF1A,HLA-A,HSPA4,HSPA5,PARK7,PLP1,PRKCE,PSMA3,PSMD10,SERPINA1	4-phenylbutyric acid,ACOX1,ATF6,CEBPB,CTNNB1,DDIT3,FOXO1,MYOC,NFKB1,NFkB (complex),PPARA,RELA,STAT3	
P3	 	TNFRSF1B	1.075	transmembrane receptor	 	1.075	bias	0.404	-0.415	7.36E-04	ABCC3,BCL2L1,CXCL12,FAS,LEP,MAP3K1,MBP,MMP14,MMP9,MSR1,NR5A2,PDGFA,SAA1,SOCS3,TYMP	AKT1,CEBPA,CEBPB,CTNNB1,FOS,FOXO1,IFNG,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,SP1,STAT3,TNF,TNFRSF1B,TP53	
P3	 	rasagiline	 	chemical drug	 	0.382	bias	0.399	-0.648	7.48E-04	ALDOC,APP,BCL2L1,EGR1,FAS,PRKCE,RACK1,SOD1,TFRC,YWHAG	APP,CREB1,ELK1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PRKCA,PRKCE,Pkc(s),RELA,STAT3,TP53,rasagiline	
P3	 	fenofibrate	 	chemical drug	 	1.314	 	0.194	0.396	7.76E-04	ADIPOQ,ALDH1A2,APOB,APP,ASNS,CEBPB,CSF1R,CYP4A11,GAPDH,GBE1,GLUL,GOT1,HADHB,HIF1A,HMOX1,HOXA7,IRF8,KPNA1,LPCAT3,MLH1,NACC1,NPC1L1,NR1H3,PAICS,PLTP,POR,PSMA4,PTPRC,SCD,SREBF1,SREBF2,THRA,TPP1,UCP2,VCAM1	ADIPOQ,CEBPA,Insulin,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,THRB,fatty acid,fenofibrate	
P3	 	IRF8	1.920	transcription regulator	 	0.948	bias	0.384	-0.814	7.79E-04	BCL2L1,CD14,CD4,CD83,CSF1R,CTSS,CXCL16,CYBB,DAB2,EGR1,FAS,FOS,GBP1,IRF8,KLF4,MAF,MAP4K4,MMP9,MSR1,OAS1,PCDH7,TYROBP	CEBPA,CEBPB,GATA1,IFNG,IL1B,IL6,IRF8,JUN,MITF,NFKB1,NFKBIA,NFkB (complex),RELA,RUNX1,SPI1,STAT3,TNF,TP53	
P3	 	N-cor	 	group	 	-0.788	bias	-0.624	 	7.84E-04	ADIPOQ,BIN1,CDK6,CXCL14,GSTP1,IGFBP3,MMP9,PCK1,PLIN1,PLIN2,RAB20,RGL1,SCD,SREBF1,USP18,XYLT1	ATF6,CEBPA,CEBPB,DDIT3,FOXO1,N-cor,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,TNF,progesterone	
P3	 	eicosapentenoic acid	 	chemical drug	 	0.823	 	-0.099	1.183	7.84E-04	APOE,CD83,CEBPB,CIDEA,CSF1R,FOS,HMOX1,LEP,MMP9,NFE2L2,NPC1L1,PLIN2,SREBF1,TGFB2,THRSP,TNFRSF1A	ATF6,Akt,CEBPA,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RXRA,SP1,SREBF1,STAT3,eicosapentenoic acid,fatty acid,oleic acid	
P3	 	methylmercury	 	chemical toxicant	 	0.535	 	0.098	0.167	7.85E-04	ACVR1C,ATF5,BCL2L1,CD63,CDK6,EGR1,HMOX1,IGFBP3,MAPKAPK2,MTPN,NR2F6,RTN4,SLC16A1,TNFRSF1A	ERK1/2,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,methylmercury	
P3	 	triamterene	 	chemical drug	Activated	3.217	bias	0.646	 	7.85E-04	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GAS5,GSTM3,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	MT-TM	-1.093	other	 	 	 	 	 	7.87E-04	MT-CO1,MT-CYB,MT-ND1,MT-RNR1,MT-TP,MT-TY	 	
P3	 	ciprofibrate	 	chemical drug	 	0.980	 	-0.030	1.123	7.94E-04	ABCB11,ANXA2,APOB,BSG,CCND2,CD63,CIDEA,CRAT,CSTB,CXCL12,CYP27A1,CYP4A11,GOT1,GSTP1,LPCAT3,MYH1,NR1H3,PLIN2,RPL12,SCD,SERPINA1,SLC16A1,SLC4A4,SQSTM1	ACOX1,CEBPA,CEBPB,Ins1,LEP,NFE2L2,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,SREBF1,SREBF2,STAT3,STAT5B,cholesterol,ciprofibrate	
P3	 	4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone	 	chemical toxicant	 	1.311	bias	0.521	 	8.10E-04	ANXA1,BCL2L1,FOS,JUNB,LCP1,NFE2L2,SERPINA1,SPP1,TKT	4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone,AKT1,Akt,ERK1/2,ESR1,ESR2,FOS,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARG,RELA,SP1,STAT3,STAT5B,TP53	
P3	 	SHC1	1.928	kinase	Activated	2.079	 	0.122	1.726	8.10E-04	BCL2L1,FOS,FTH1,FTL,GSTP1,KLF2,NQO1,SQSTM1,TXN	CTNNB1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,Ras,SHC1,SP1,SRC,STAT3,TP53	
P3	 	BRD4	1.234	kinase	Activated	2.524	bias	0.684	 	8.14E-04	ALDH1B1,BCL2L1,CCND2,CD4,FOS,GTF3C6,HMOX1,MLF2,MTHFD1L,MTMR2,NME1,NQO1,SFXN4,SLC7A2,SMARCA4,SRM,STC2	 	
P3	 	CHI3L1	4.829	enzyme	 	 	 	 	 	8.19E-04	ARL4C,CDH11,COL16A1,COL6A1,EMP1,MMP9,NNMT,PEG10	 	
P3	 	TRIB3	16.689	kinase	Inhibited	-2.778	bias	-0.328	-1.868	8.19E-04	ASNS,DDIT3,GARS,GDF15,PCK2,PSAT1,STC2,TRIB3	ATF4,CEBPA,CEBPB,CTNNB1,DDIT3,FOS,JUN,Jnk,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT3,TRIB3	
P3	 	diazoxide	 	chemical drug	 	0.290	 	-0.237	0.948	8.19E-04	BCL2L1,CYCS,EGR1,HYOU1,LEP,ODC1,SLC39A6,UCP2	ADIPOQ,D-glucose,ERK,HIF1A,Insulin,JUN,LEP,MYC,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,diazoxide	
P3	 	ATF6	1.574	transcription regulator	 	1.445	bias	0.525	 	8.20E-04	APP,CALR,CEBPB,DDIT3,FOS,HSPA5,NUCB2,PCK1,PLIN2,PRNP,PVR,RAN,SRR	APP,ATF6,Akt,CEBPB,DDIT3,HIF1A,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53	
P3	 	melatonin	 	chemical - endogenous mammalian	 	-0.096	 	-0.037	0.054	8.20E-04	BCL2L1,CYCS,FAS,FOS,GJB2,HIF1A,HMOX1,HSPA9,JUNB,LEP,MMP9,NCAM1,NFE2L2,NQO1,PLAT,SOD1,SOX9,SPP1,SQSTM1,STS	Akt,CEBPA,CTNNB1,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),Pkc(s),RELA,SP1,STAT3,TNF,melatonin	
P3	 	SOX4	1.341	transcription regulator	 	1.316	bias	0.437	-0.961	8.26E-04	AES,ALDH1B1,B3GNT5,CAPN2,CD53,CHAC1,CLIC6,CNRIP1,CTNNA1,DUSP4,EMP1,FCER1G,FHL1,FOS,IFI30,IGFBP4,LYZ,MARCKSL1,MBP,NCAM1,NUAK1,SERPINE2,SLC2A6,SNX10,TAX1BP3,TENM4,TMEM176B,UCHL1	CTNNB1,JUN,NFkB (complex),SOX4,STAT3,TCF7L2,TP53	
P3	 	MAPKAPK2	2.517	kinase	 	1.445	bias	0.348	0.273	8.32E-04	DDIT3,HSPA5,HSPB6,HSPB8,LMO4,MMP9,MSR1,PLAT,PLAU,RILPL1,TOP2A,VCAM1	CTNNB1,EGFR,ERK1/2,FGF2,FOXO3,IL6,JUN,MAPKAPK2,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,VEGFA,estrogen receptor	
P3	 	colchicine	 	chemical drug	 	0.700	 	0.207	0.048	8.32E-04	ABCB11,ADCYAP1,CTGF,FAS,FOS,HIF1A,LEP,NQO1,SOX9,TMEM123,TNFRSF1A,TUBA1B	CAV1,CEBPA,CTNNB1,Creb,FOS,FOXO1,HIF1A,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SIRT1,STAT3,TNF,TP53,colchicine,reactive oxygen species	
P3	 	salirasib	 	chemical drug	 	-0.810	bias	-0.546	 	8.32E-04	ALDOC,ATF4,COL5A2,HIF1A,HRAS,P4HA1,PFKFB3,PGAM1,PKM,PLAT,PLAU,PLOD2	HRAS,NFKBIA,RELA,SP1,STAT3,TP53,salirasib	
P3	 	EPAS1	-1.060	transcription regulator	 	0.567	bias	0.550	 	8.40E-04	ALDOC,C1QA,CA12,CTGF,DDIT3,EGLN3,EIF5A,ENO1,FHL1,FOS,GBE1,HIF1A,HMGCS1,HSPA4,HSPA5,IGFBP3,ITGAV,MMP14,PFKFB3,PLIN2,PLOD2,RET,SLC6A8,SLC7A5,SOD1,SOX9,SREBF1,STC2,UNG	CTNNB1,EGFR,ELK1,EPAS1,JUN,MYC,NFE2L2,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,SP1,SREBF1,STAT3,TP53,estrogen receptor,fatty acid,nitric oxide,sphingosine-1-phosphate	
P3	 	HOXA9	-38.620	transcription regulator	 	0.000	bias	0.344	-0.842	8.84E-04	AHCYL1,ARF1,ARL3,ARPC5,CALCRL,CBX6,CLCN7,CLTC,CTSG,CYBB,HIGD1A,IRX6,JUNB,KIT,LYZ,MAFG,NLK,PPP1R16B,PTPRC,RPL37A,RPS3A,SDC4,SDCBP,SERINC2,SPP1,WSB1,YWHAG	 	
P3	 	IKBKG	 	kinase	Activated	2.205	bias	0.542	 	8.96E-04	CEBPB,CSF1,CTSB,CXCL12,DUSP6,FOS,GM2A,GRN,HLA-A,IGFBP6,IL1RN,JUNB,NAGLU,NR6A1,PCDH7,PLD3,PTX3,SERPINE2,SFRP1,SOCS3,TMEM176B	CEBPA,CHUK,CTNNB1,IKBKB,IKBKG,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	NGF	-1.161	growth factor	 	1.609	bias	0.408	-0.393	9.02E-04	ANXA2,APP,BCL2L1,BTG2,CD83,DUSP1,DUSP4,EEF1A1,EGLN3,EGR1,ETV5,FAS,FOS,GSK3B,HMOX1,JUNB,MMP9,MT-CO1,NAB2,NR4A1,RACK1,SHC1,SOD1,SQSTM1,TACR1,TNFRSF12A,TRPA1,TXN	CTNNB1,FOS,HIF1A,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NGF,Pkc(s),RELA,STAT3,TP53	
P3	 	ethanol	 	chemical - endogenous mammalian	Activated	2.813	 	0.203	1.532	9.06E-04	ADAM17,ADCYAP1R1,ADIPOQ,BCL2L1,C3AR1,CD14,CEBPB,CNR1,CTGF,CYP4A11,DDIT3,DUSP1,DUSP6,EGR1,EPHX1,FAS,FOS,FOSB,GDE1,HDAC2,HIF1A,HLA-A,HMOX1,HSP90AB1,HSPA5,HTATIP2,IL1RN,MAP1B,MAT2A,MBP,MMP9,NQO1,PCK1,PHB,PHLDA2,PLAT,PLIN1,PPP1R1B,PPP1R3C,SCD,SERPINA1,SLC7A11,SREBF1,STIM1,SYNPO2,TGFB2,VCAM1	CEBPA,CEBPB,IFNG,IKBKB,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53,ethanol	
P3	 	PPP3CA	-1.193	phosphatase	 	 	 	 	 	9.18E-04	APP,FTL,GRN,GSTP1,LAMP2,LITAF,LPAR1,MYH1,PRDX5,PSAP,PTGFR,SDC4,SPP1,STS	JUN,NFKB1,NFKBIA,NFkB (complex),PPP3CA,RELA,STAT3	
P3	 	streptozocin	 	chemical drug	 	0.215	 	0.116	-0.355	9.24E-04	ABCB11,ALDH3A2,ALPL,BCL2L1,CCND3,CTGF,CYP4A11,FAS,FOS,HIF1A,HMOX1,HSD11B2,HSPD1,KIT,LEP,MMP9,MSR1,NQO1,NTRK3,OGT,PCK1,SCD,SLC25A11,SLC25A5,SLC2A5,SOD1,SPP1,SREBF1,STUB1,TNFRSF1A,VDAC1	AKT1,Akt,CEBPB,CREBBP,ELK1,ESR1,FOXO1,Insulin,JUN,LEP,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,TP53,streptozocin	
P3	 	captopril	 	chemical drug	Activated	2.882	 	0.173	2.219	9.89E-04	ANXA1,ASNS,CAPN6,FCGR2A,GAS5,GSTM3,HMOX1,IGFBP6,IL1RN,MMP9,S100A11,SPP1,TGFB2,TMSB10/TMSB4X,TNFRSF12A	AGT,AKT1,AMPK,FOXO1,FOXO3,HIF1A,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARA,PPARG,PPARGC1A,RELA,SIRT1,SP1,SREBF1,TP53,captopril,fatty acid	
P3	 	herbimycin	 	chemical - kinase inhibitor	 	-0.183	bias	-0.432	1.238	9.90E-04	BCL2L1,CCND3,CDK6,CTGF,DUSP1,FOS,JUNB,MMP9,PLAU,SIRPA,TNFRSF1A	CTNNB1,EGFR,ERK,ERK1/2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,estrogen receptor,herbimycin	
P3	 	RAB1B	1.905	other	 	1.000	bias	0.409	-0.226	1.03E-03	COPG1,DERL1,GEM,GORASP2,RAB11FIP2,RAB32,RRAGC,STXBP1,YIF1A	 	
P3	 	S-adenosylmethionine	 	chemical - endogenous mammalian	 	-1.093	bias	-0.452	0.234	1.03E-03	FOS,GCLM,HMOX1,MAF,MAFG,MAT2A,PHB,PLAU,SREBF1	ADIPOQ,CEBPA,CEBPB,CREBBP,CTNNB1,ELK1,ESR1,FOS,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,S-adenosylmethionine,SP1,STAT3,TNF,TP53	
P3	 	vitamin K3	 	chemical drug	 	0.960	bias	0.596	 	1.08E-03	ABCC1,BMP6,DDIT3,EGR1,FAS,FOS,HMOX1,HSPA5	ATF6,CEBPB,CTNNB1,DDIT3,FOS,FOXO1,FOXO3,IL1B,Jnk,MAP2K1/2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53,vitamin K3	
P3	 	CLCN5	1.329	ion channel	 	-0.391	 	-0.142	-0.076	1.12E-03	CTSB,CUBN,MKI67,SOD1,TXN	 	
P3	 	DRD1	1.870	g-protein coupled receptor	 	-1.996	bias	0.710	 	1.12E-03	EGR1,FOS,FOSB,JUNB,TACR1	AKT1,CEBPB,CREB1,CREBBP,Creb,DRD1,EP300,ERK1/2,FOXO1,L-dopa,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,SP1,STAT3,TP53,cyclic AMP	
P3	 	HIC1	1.650	transcription regulator	 	-1.457	 	-0.122	-1.019	1.14E-03	ANO2,CA12,CXCL14,FST,ID4,KAZN,LRP8,MAP2K3,MCAM,SLC7A11,SOX9,SPP1,TRIM16	 	
P3	 	Ins1	 	other	 	1.287	bias	0.277	-0.391	1.14E-03	ACTB,ADIPOQ,ALAS1,ARF1,CCND3,CEBPB,CRAT,DDIT3,DGAT2,DYNLL1,EGR1,ERP29,FOS,GAPDH,GSTP1,HMGCS1,HNRNPK,HSD11B2,IGFBP3,IGFBP4,IMPDH2,IVD,JUNB,LEP,MAPT,MBP,NDUFB9,NDUFS4,NR1H3,ODC1,PCK1,PLAT,PLIN1,PLIN2,PPIB,SCD,SOCS3,SREBF1,THRSP,UBE2D2,UQCRC1,VAMP5	ATF6,CEBPA,CEBPB,CREBBP,FOXO1,IGF1,Ins1,JUN,LEP,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT3,STAT5B,cyclic AMP,oleic acid	
P3	 	PGR	-2.001	ligand-dependent nuclear receptor	Activated	3.635	bias	0.457	1.015	1.15E-03	AHCYL1,AKR1C3,BCL2L1,CA12,CAPN2,CCND3,CEBPB,COL6A1,COMT,CTSD,DDX21,DYNLL1,FAM49A,FKBP5,FOS,GLUL,GOT1,GSTM3,HIF1A,HSD11B2,HSPA2,KCNG1,KLF4,MAP2K3,MAT2A,MFAP5,NOP16,NQO2,P4HA2,PDGFA,PFKFB3,PLAU,PPIF,SERPINA1,SLC7A5,SLC9A1,UGCG	CEBPA,CEBPB,EP300,ERK1/2,ESR2,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SRC,STAT3,TP53,dexamethasone,progesterone	
P3	 	Hsp70	 	group	 	0.216	bias	0.252	-0.491	1.15E-03	BCL2L1,CD14,CD83,GAPDH,HCST,HIF1A,HRAS,MAPT,TYROBP,VCAM1	CTNNB1,FOS,HSF1,HSF2,Hsp70,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3	
P3	 	MXI1	-1.021	transcription regulator	Inhibited	-2.433	bias	-0.710	 	1.17E-03	IARS,IMPDH2,MKI67,ODC1,SLC1A4,SLC7A1	 	
P3	 	diethylmaleate	 	chemical toxicant	Activated	2.378	 	0.089	2.167	1.17E-03	GSTP1,HMOX1,MAFG,NQO1,SLC3A2,SLC7A11	BACH1,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA,diethylmaleate	
P3	 	FGF19	-4.898	growth factor	 	-1.664	 	-0.059	-1.521	1.18E-03	APOE,BCL2L1,BTG3,CLIC6,EGR1,FOS,G0S2,IL1RN,LEP,MCAM,SCD,SERPINA1,SLC2A5,SREBF1,TCEA1,THRSP	ADIPOQ,CEBPB,CTNNB1,ERK,ERK1/2,FGF19,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SP1,STAT3	
P3	 	FANCC	-1.784	other	 	 	 	 	 	1.19E-03	CASK,CXCL12,GDF15,HSPA4,IGFBP3,NUAK1,OAS1,PCLO,PHLDA2,PTPRC,PTX3,SYPL1	 	
P3	 	caffeic acid phenethyl ester	 	chemical drug	 	-0.793	bias	-0.531	 	1.20E-03	BCL2L1,CD83,CTSB,DDIT3,EGR1,ELOVL1,FTH1,FTL,HMOX1,IGFBP6,LEP,MKI67,MMP14,NFE2L2,NQO1,PTGFR,TCP1,VCAM1	CTNNB1,ELK1,FOS,FOXO1,HIF1A,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,caffeic acid phenethyl ester,nitric oxide,reactive oxygen species	
P3	 	NFKB1	-1.034	transcription regulator	 	1.813	bias	0.495	-0.372	1.22E-03	AKR1B1,APOE,APP,BCL2L1,BTG2,CCND2,CD3G,CFTR,CHI3L1,CSF1,CTSB,CYBB,DUSP1,EGR1,FAS,FOS,FSCN1,GBP1,HMOX1,IGFBP3,IL1RN,MAT2A,MMP9,MSR1,NR4A1,PDGFA,PLAU,PRKACA,PTX3,RACK1,SDC4,SOX9,STIM1,VCAM1	CEBPA,CEBPB,CREBBP,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT3,TNF,TP53	
P3	 	5-hydroxytryptamine	 	chemical - endogenous mammalian	 	0.095	bias	0.552	 	1.24E-03	ALDH1A2,CTGF,CYBB,CYP1B1,EGR1,FOS,HIF1A,NR4A1,NUCB2,STAB1,THBS1,TNFRSF1A,UCP2,VCAM1	5-hydroxytryptamine,CEBPA,CTNNB1,ERK1/2,FOS,IL6,Insulin,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF	
P3	 	fenamic acid	 	chemical reagent	Activated	3.231	bias	0.607	 	1.24E-03	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GAS5,GSTM3,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	DGAT2	3.026	enzyme	 	1.067	bias	0.304	0.464	1.29E-03	DGAT2,SCD,SREBF1,UCP2	DGAT2,JUN,NFkB (complex),PPARA,PPARG,SREBF1,fatty acid	
P3	 	GNE	1.096	kinase	Inhibited	-2.000	bias	-0.304	-1.391	1.29E-03	ASNS,CHAC1,DDIT3,TRIB3	 	
P3	 	MRPL14	2.372	other	 	0.000	bias	0.710	 	1.29E-03	COX4I1,MALSU1,MT-CO1,MT-ND1	 	
P3	 	RFWD2	1.195	enzyme	 	1.961	bias	0.304	1.364	1.29E-03	CEBPB,FAS,SREBF1,TRIB3	Akt,JUN,MYC,NFKBIA,NFkB (complex),RELA,RFWD2,SP1,STAT3,TP53	
P3	 	ritonavir	 	chemical drug	 	-0.314	 	-0.142	0.058	1.31E-03	ADIPOQ,ALAS1,BCL2L1,C9orf72,CARS,CCND2,CFL1,CYP2B7P,EIF5,LEP,ME1,MMP9,MRPL47,MSMO1,PNRC2,SCD,SREBF1,SREBF2,TSN,TWF2,USP18,VCAM1	ADIPOQ,CEBPA,CEBPB,FOS,FOXO1,Ins1,JUN,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,SRC,SREBF1,STAT3,fatty acid,palmitic acid,ritonavir	
P3	 	ELAVL1	1.093	other	 	1.165	bias	0.521	 	1.31E-03	BCL2L1,CALM1 (includes others),CD83,DUSP1,EIF4E2,FLNA,FOS,GSS,HMOX1,HSPA2,RACK1,RPL13,RPN2,SLC25A11,TRIOBP	CTNNB1,ELAVL1,MMP9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P3	 	A23187	 	chemical reagent	 	0.970	bias	0.442	-0.885	1.32E-03	CALR,CD14,CD83,CYCS,DDIT3,DVL3,EGR1,EIF6,FOS,FOSB,HSPA5,JUNB,MSR1,MYH1,NR4A1,ODC1,SHC1,THRSP,TPO	A23187,CEBPA,CEBPB,CREBBP,CTNNB1,FOS,Insulin,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF,cyclic AMP	
P3	 	EP300	1.150	transcription regulator	 	1.246	bias	0.593	 	1.37E-03	ADAM12,ADIPOQ,ARHGEF10L,BCL2L1,BMF,CAMK2D,CAPG,CCND3,CD53,COMT,CRISPLD2,DDX3Y,DGKE,DUSP1,DUSP4,EGR1,EPSTI1,FTH1,GM2A,GNG2,GSK3B,HLA-G,HMOX1,HSD11B2,HSP90AB1,IL10RA,ITGB2,KCTD1,LEP,MAF,MAFG,MKI67,NPAS2,NR4A1,NTRK3,PCK1,PDGFA,PLAA,PPFIBP2,RAPGEF3,RGL1,RNF157,SDC4,SLC7A11,SOCS3,TGFB2,TNFAIP8L2,TPO,USP18,WNT5B,XIST,XRCC6	ARNT,CEBPA,CEBPB,CREBBP,CTNNB1,EP300,FOXO1,HIF1A,HMGA1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT3,TNF,TP53	
P3	 	diallyl trisulfide	 	chemical - endogenous non-mammalian	 	1.293	 	0.158	0.914	1.39E-03	ABCC6,BCL2L1,FAS,FOS,HMOX1,NFE2L2,NQO1	Akt,CTNNB1,ERK,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,diallyl trisulfide,reactive oxygen species	
P3	 	selenomethylselenocysteine	 	chemical - endogenous mammalian	 	-0.239	bias	-0.387	0.779	1.39E-03	ABCC1,CES1,EGR1,PSME1,RPS11,RPS12,SOD1	 	
P3	 	NPM1	1.783	transcription regulator	 	1.000	 	0.079	0.842	1.41E-03	ALK,CSF1,HOXA10,HOXA7,HOXB5,LTF,MMP9,NPM1	 	
P3	 	PLIN5	-2.666	other	Activated	2.828	 	-0.051	2.972	1.41E-03	ACSM5,ATF4,GSS,HMOX1,NFE2L2,NQO1,POR,TXNRD1	 	
P3	 	arginine	 	chemical - endogenous mammalian	 	0.141	 	0.131	-0.211	1.41E-03	BCL2L1,DDIT3,EGR1,HIF1A,HSPA5,PCK2,SCD,SLC7A5	CEBPA,D-glucose,FOXO1,FOXO3,HIF1A,IGF1,INS,Insulin,JUN,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,arginine	
P3	 	indole-3-carbinol	 	chemical drug	 	-0.290	 	0.000	-0.290	1.41E-03	ANXA1,CDK6,FMO1,FOS,GDF15,LCP1,NFE2L2,SPP1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,indole-3-carbinol	
P3	 	leucine	 	chemical - endogenous mammalian	 	-0.431	 	0.055	-0.573	1.41E-03	ASNS,ATF4,CRAT,DDIT3,EEF1A1,FOS,NR4A1,SREBF1	CEBPA,CEBPB,CTNNB1,FOXO1,FOXO3,HMGA1,INS,IRS1,Ins1,MTORC1,NFE2L2,NFkB (complex),PI3K (complex),PPARA,PPARG,RELA,SP1,SREBF1,SREBF2,STAT3,leucine	
P3	 	nitroarginine	 	chemical reagent	 	0.027	bias	0.355	-0.966	1.41E-03	CD53,EGR1,GCLM,HMOX1,NCAM1,PLAT,SPP1,TNFRSF1A	AKT1,AMPK,ELK1,FOXO1,FOXO3,JUN,NFE2L2,NFKBIA,NFkB (complex),NR4A1,PPARGC1A,RELA,SIRT1,SP1,TP53,nitric oxide,nitroarginine	
P3	 	thioctic acid	 	chemical drug	 	-0.644	bias	-0.304	0.344	1.41E-03	ABCC1,FOS,HMOX1,LEP,MMP9,NFE2L2,NQO1,PARK7,SLC7A11,SOD1,UCP2,VCAM1	Akt,BACH1,CEBPA,CTNNB1,FOS,FOXO1,JUN,Jnk,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3,TNF,thioctic acid	
P3	 	PTH	-2.323	other	 	0.503	bias	0.428	-1.270	1.41E-03	CEBPB,CSF1,CTGF,CXCL12,DUSP1,FOS,FOSB,GNG12,ID4,IGFBP3,ITGAV,LIMA1,NR4A1,ODC1,PDGFA,PHLDB2,PLAU,PPP1R1B,RMDN3,SDC4,SFRP2,SOCS3,SPP1,TNS1	CEBPB,CREBBP,CTNNB1,ERK1/2,FOS,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTH,RELA,STAT3,cyclic AMP	
P3	 	MUC1	-2.795	other	 	1.449	bias	0.326	0.566	1.42E-03	ABCC1,BCL2L1,CD83,CDH11,EGLN3,HIF1A,MKI67,PDGFA,PLAU,SOD1	ARNT,CEBPA,CTNNB1,ESR1,FOXO1,FOXO3,HIF1A,MUC1,MXI1,NFKB1,NFKBIA,NFkB (complex),PIK3R1,PPARG,RELA,STAT3,TNF,TP53	
P3	 	T3-TR-RXR	 	complex	 	1.234	bias	0.572	 	1.42E-03	AKR1C1/AKR1C2,AKR1C3,ENO1,ME1,PCK1,SREBF1,SREBF2,SYT2,THRSP,UCP2	 	
P3	 	emodin	 	chemical drug	 	-1.254	bias	-0.355	-0.404	1.42E-03	ABCC1,ADIPOQ,CLDN5,CYP1B1,HSPA5,LEP,MKI67,MMP9,SOD1,VCAM1	CEBPB,CREBBP,ERK1/2,JUN,MAP2K1,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT3,TP53,emodin,troglitazone	
P3	 	tetrachlorodibenzodioxin	 	chemical toxicant	 	0.902	 	0.039	0.714	1.44E-03	AARS,ACTN1,ASNS,ATF4,BCAT1,CEBPB,CES1,CHST2,CMA1,COL6A1,COMT,CTSD,CYP1B1,CYP4A11,CYP4B1,CYR61,DMXL2,FAS,FOS,GHITM,HMOX1,HRAS,HSPA2,HSPA8,IL10RA,KLF2,MMP14,MNAT1,NFE2L2,NME1,NQO1,ODC1,PCK1,POMP,PTGFR,RAB10,SAA1,SERPINH1,SHB,SIM1,SLC25A5,SLC38A3,SLC4A2,SOD1,STC2,TGFB2,TXN	17-alpha-ethinylestradiol,AHR,Akt,CEBPA,ESR1,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT3,TNF,TP53,tetrachlorodibenzodioxin	
P3	 	FAS	2.374	transmembrane receptor	 	-0.285	 	-0.103	0.106	1.53E-03	ANXA2,ARFGAP1,ARHGDIA,BCL2L1,BTG3,CD300C,CD83,COL15A1,COL6A1,COL8A1,CSF1,CTGF,DUSP10,EGR1,F5,FAS,FOS,FOSB,FSCN1,GBP1,GDE1,IL10RA,ITGAV,KIF3B,MAP4K4,MMP9,MYO5A,NR4A1,PHLDA2,PLAU,PLIN2,PPFIBP2,PTP4A2,PTX3,RRAGD,SHC1,SIAH2,SORL1,SPP1,TFRC,TIAL1,TLN2,TNFRSF1A,TRAF3,TWF2,UGCG,VCAM1	CTNNB1,FAS,FOS,HIF1A,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P3	 	FOLR1	1.698	transporter	 	 	 	 	 	1.53E-03	ALDOC,ATP6V1B2,CLPTM1,DNASE2,DTD1,DUSP6,GAS5,GBA,LPAR1,LYZ,MRPS6,PFN1,RPS24,SLC3A2,SNRPF,ST3GAL6,SYNGR2	 	
P3	 	10E,12Z-octadecadienoic acid	 	chemical - endogenous mammalian	Activated	2.127	 	0.159	1.603	1.56E-03	ADIPOQ,ATF4,DDIT3,GDF15,ME1,NR4A1,PLIN1,PLIN2,SCD,SORBS1,SREBF1,TRIB3,UCP2	10E,12Z-octadecadienoic acid,ATF6,CEBPA,CEBPB,FOXO1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,fatty acid,oleic acid,palmitic acid	
P3	 	gentamicin C	 	chemical drug	Activated	3.051	bias	0.620	 	1.56E-03	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GAS5,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	lovastatin	 	chemical drug	 	1.369	 	0.189	0.659	1.58E-03	ADIPOQ,APOE,ATF4,BCL2L1,CCND3,CTGF,DDIT3,EBNA1BP2,HMGCS1,HMOX1,KLF2,LEP,MKI67,MVD,PLAT,PMVK,SDC4,SREBF1,SREBF2,TFPI	AKT1,APOE,CEBPA,CTNNB1,FOXO1,LDL,NFKB1,NFKBIA,NFkB (complex),NR4A1,PPARA,PPARGC1A,RELA,SP1,SREBF1,SREBF2,STAT3,TNF,TP53,lovastatin	
P3	 	raloxifene	 	chemical drug	 	0.102	 	0.000	0.102	1.60E-03	ALDH4A1,CBX6,CNBP,CSF1,CXCL12,CYP1B1,DUSP1,DUSP4,DYNLL1,ESR2,HMOX1,IFI30,IGFBP4,LITAF,MATN2,MFAP5,MKI67,PAX5,PPP1R3C,SIAH2,SNCG,SOD1,SPP1,TFRC,TGFB2,TOP2A	CEBPA,CTNNB1,EGFR,ESR1,ESR2,IGF1,IL6,JUN,MYC,NFKB1,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TP53,estrogen receptor,raloxifene	
P3	 	GAPDH	3.187	enzyme	 	-0.511	bias	-0.292	0.344	1.63E-03	BCL2L1,DUSP1,ENO1,FCER1G,GAPDH,GEM,OAS1,SPP1,WARS	 	
P3	 	TEAD4	-1.755	transcription regulator	 	1.131	bias	0.355	0.428	1.63E-03	CTGF,CYR61,DES,FGFR2,GATAD2A,HIF1A,JUNB,MYH1,TP63	MYC,NFKB1,NFkB (complex),RELA,STAT3,TEAD4,VEGFA	
P3	 	ADCYAP1	5.560	other	 	0.981	 	0.170	0.035	1.66E-03	ACTN1,ADCYAP1,ADCYAP1R1,BMP6,BTG2,CCNI,CEBPB,CFL1,CNTNAP4,COL5A2,EDIL3,EGR1,FGFR2,FOS,FST,GCLM,GPC3,H2AFZ,HK1,MCAM,NPY1R,NPY5R,NQO1,POR,PSMB7,RPSA,SELT,SERPINE2,SOCS3,TGFB2,TMSB10/TMSB4X,TXNRD1,UCP2	ADCYAP1,CEBPA,CREB1,Creb,ERK,FOS,GNRH1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TNF,norepinephrine	
P3	 	TSH	 	complex	 	0.384	bias	0.459	-1.091	1.66E-03	CCND3,CTSS,EGR1,ERP29,FOS,FTH1,GAPDH,IGFBP3,IL1RN,JUNB,SOCS3,TPO	CEBPB,CREBBP,ERK1/2,HRAS,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TP53,TSH,cyclic AMP,phorbol myristate acetate	
P3	 	PIK3R1	-1.695	kinase	Activated	2.561	bias	0.480	0.862	1.66E-03	ATF5,BCL2L1,CCND2,DDIT3,FOS,HIF1A,HMOX1,MKI67,NFE2L1,NFE2L2,PCK1,PKM,PLAU,VCAM1	Akt,CEBPB,CTNNB1,FOS,FOXO1,JUN,Jnk,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),PIK3R1,RELA,SP1,SRC,STAT3	
P3	 	ADRB3	-1.674	g-protein coupled receptor	 	-0.365	bias	0.426	-1.299	1.69E-03	CXCL12,EGR1,FOS,JUNB,LEP,UCP2	ADIPOQ,ADRB3,CREB1,CREBBP,Creb,EP300,FOXO1,FOXO3,INS,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,isoproterenol	
P3	 	MMP1	-2.838	peptidase	 	1.473	bias	0.266	0.894	1.69E-03	CXCL12,EGR1,HIF1A,MMP9,PLTP,TACR1	ERK1/2,F2R,IL1B,JUN,MMP1,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,VEGFA	
P3	 	triclosan	 	chemical drug	 	0.447	bias	0.521	 	1.69E-03	CYBB,FOS,HMOX1,MBD3,NQO1,PLAU	 	
P3	 	IKBKB	-1.261	kinase	Activated	2.633	bias	0.485	-0.179	1.70E-03	BCL2L1,CEBPB,CSF1,CTSB,CXCL12,CYP1B1,DUSP6,EGR1,FAS,FOS,GM2A,GRN,HIF1A,HLA-A,HMOX1,IGFBP6,IL1RN,JUNB,MAT2A,MBP,MMP9,MYO1D,NAGLU,NR6A1,PCDH7,PLAU,PLD3,PLIN1,PTX3,SERPINE2,SFRP1,SOCS3,TMEM176B,TP63,VCAM1	CEBPA,CHUK,CTNNB1,IKBKB,IKBKG,IL1B,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	ELK1	1.353	transcription regulator	 	-0.808	bias	0.595	 	1.72E-03	BCL2L1,EGR1,FOS,ITGAV,JUNB,MECOM,MMP9,NUPR1,SLC7A11,SPP1,THBS1	CEBPA,ELK1,ERK,ETS1,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF	
P3	 	glucosamine	 	chemical - endogenous mammalian	 	-0.967	 	-0.161	-0.472	1.72E-03	APOB,ASS1,DDIT3,LEP,MDH2,MT-ND1,NDUFA1,NDUFB9,PCCB,SLC25A11,SLC25A5	CEBPA,CEBPB,CREB1,ELK1,FOXO1,IGF1R,INSR,Ins1,Insulin,JUN,LEP,NFKB1,PDX1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,estrogen receptor,glucosamine	
P3	 	guanidinopropionic acid	 	chemical - endogenous non-mammalian	Activated	3.146	bias	0.710	 	1.72E-03	ALAS1,ATP5G1,COX4I1,CYC1,CYCS,MYH1,NDUFA1,NDUFA11,NDUFA12,NDUFB4,NDUFS4	FOXO3,HIF1A,NFKBIA,PRKAA2,RELA,TP53,guanidinopropionic acid	
P3	 	advanced glycation end-products	 	chemical - endogenous mammalian	 	1.749	bias	0.355	0.651	1.72E-03	BSG,CLDN5,CTGF,CXCL12,KLF2,MKI67,MMP9,PFN1,SPP1,VCAM1	ATF4,Akt,CTNNB1,E2F1,ELK1,FOXO1,JUN,MMP9,NFE2L2,NFKB1,NFkB (complex),PPARG,Pkc(s),RELA,SIRT1,SP1,STAT3,advanced glycation end-products,nitric oxide	
P3	 	daidzein	 	chemical drug	 	0.500	 	0.203	-0.312	1.74E-03	ABCC3,ADIPOQ,AIF1,AKR1C3,CD4,FERMT3,FOSB,HCST,HLA-A,ITGB2,KLRD1,LAPTM5,MAL2,MMRN1,OGDH,PLCXD3	ESR1,ESR2,HIF1A,RELA,STAT3,beta-estradiol,daidzein	
P3	 	cocaine	 	chemical drug	 	-0.830	bias	0.454	-2.973	1.74E-03	ADCY1,CNR1,DUSP1,DYNLL1,EGR1,FOS,FOSB,GNB1,HSPA4,JUNB,MAPT,MKNK2,NAB2,NACC1,NR4A1,OAS1,PLCXD1,PPP1R1B,PRKACA,PSAP,SDK1,SIAH2,SIGMAR1,THBS1,TSPO,TUBB	BDNF,CREB1,CREBBP,CREM,Creb,DRD1,ELK1,FOS,HTT,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,RNA polymerase II,STAT3,cocaine,estrogen receptor	
P3	 	CDK5R1	-1.165	kinase	 	 	 	 	 	1.79E-03	CD14,CD63,FOS,MAPT,PPP1R1B	CDK5,CDK5R1,CREBBP,Creb,EP300,JUN,TP53	
P3	 	NELFB	1.529	other	 	1.342	 	-0.118	1.606	1.79E-03	COL6A1,CTGF,MKNK2,RPLP0,RPS3	 	
P3	 	TIMP3	1.059	other	 	-1.067	bias	-0.323	-0.428	1.79E-03	APP,FAS,KIT,LRP8,MMP9	CASP8,CTNNB1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TIMP3,TNFRSF1B,TP53	
P3	 	mannose	 	chemical - endogenous mammalian	Inhibited	-2.236	 	0.237	-2.765	1.79E-03	ATF4,FOS,HSPA5,NR4A1,THBS1	CDKN2A,CEBPA,CTNNB1,EP300,FOS,IL6,Insulin,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TNF,TP53,YY1,mannose	
P3	 	testosterone	 	chemical - endogenous mammalian	 	1.981	bias	0.342	-0.207	1.79E-03	ADIPOQ,ADRA2A,ALDOA,ANXA1,ATP6V1F,CLCN3,COX5A,DDX3Y,EGR1,EIF2S1,ESR2,FAS,FGFR2,FOS,FOSB,FST,GMFB,GPC1,HIF1A,HNRNPK,HSP90AB1,HSPD1,LEP,MT-CO1,MT-CYB,MT-ND5,NR5A2,ODC1,PDAP1,PLAU,PRKCE,RALA,RPL21,RPS11,SLC9A1,SNRNP25,SYT11,TGFB2,THBS1,TOP2A,TUBB2A,TXNRD1,VCAM1	CEBPA,ERK1/2,ESR1,ESR2,FGF2,FOXO3,HIF1A,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,beta-estradiol,testosterone	
P3	 	HNF1A	-2.993	transcription regulator	 	0.575	bias	0.654	 	1.79E-03	AKR1C1/AKR1C2,AKR1C3,APOB,BAG6,BCL2L1,CLDN2,CMC2,COL27A1,CREBL2,CYB5B,CYP27A1,DUSP6,ETV5,F8,FAS,FBXO8,FH,FMO1,G0S2,GARS,GBE1,GLUL,GNG12,GOT1,HPGDS,HSPA5,LIPA,LY6E,MID1IP1,NOP16,NPC1L1,NR1D1,NR5A2,OGDH,PCK1,PFKL,PNO1,POLR1A,PSMA5,RACK1,SEL1L,SERPINA1,SLC12A7,SLC4A2,SLC7A2,SOCS3,SUPV3L1,TARS,TFRC,TMEM33,TSC22D2,TXNDC12,UCP2,WDR12	D-glucose,HIF1A,HNF1A,HNF4A,MYC,PPARG,RELA,STAT3	
P3	 	dichlorovinylcysteine	 	chemical toxicant	 	-1.907	 	-0.164	-1.487	1.80E-03	CDK6,ENO1,HSPA9,MDH2,ODC1,PKM,PRDX5,STIP1	 	
P3	 	P38 MAPK	 	group	 	1.923	bias	0.584	 	1.86E-03	ADAM17,ADIPOQ,ANXA5,ASS1,BCL2L1,CCND2,CD83,CEBPB,CLDN5,CTGF,CXCL12,CYBB,DDIT3,DES,DUSP1,EDNRB,EGR1,FAS,FLNA,FOS,FST,GBP1,HIF1A,HMOX1,HSPA5,IL1RN,ITGAV,ITGB2,JUNB,KLF4,LDB3,LEP,MAP4K4,MMP9,NFE2L2,NR4A1,PCK1,PLAU,RAB7A,SOCS3,STIM1,THBS1,TNFRSF1A,TOP2A,VCAM1	CEBPA,CEBPB,CTNNB1,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	NTRK1	-3.966	kinase	 	-0.130	bias	0.615	 	1.86E-03	BCL2L1,EGR1,FOS,MMP9,NR4A1,RET,TACR1	CREB1,Creb,ELK1,ERK1/2,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),NGF,NTRK1,P38 MAPK,Pkc(s),RELA,SP1,STAT3,TP53	
P3	 	CCL5	 	cytokine	Activated	2.017	bias	0.646	 	1.91E-03	ALCAM,ATF4,CAPN2,CYP1B1,DUSP1,DUSP6,EMP1,FOS,HMGA1,LIMS1,MMP9,PPIF,SOD1,TUBB4B	CCL5,CEBPA,ELK1,ERK,FOXO1,FOXO3,JUN,MAP2K1/2,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RAF1,RELA,SP1,STAT3,TNF,TP53,nitric oxide	
P3	 	methamphetamine	 	chemical drug	 	0.322	bias	0.259	-0.553	1.91E-03	ABCC1,BCL2L1,EGR1,FAS,FOS,FOSB,HMOX1,MMP9,NR4A1,PCLO,SIGMAR1,TNFRSF1A,TXN,VCAM1	5-hydroxytryptamine,CEBPA,ERK,FOXO3,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,methamphetamine	
P3	 	DDIT3	6.382	transcription regulator	Activated	3.077	bias	0.368	1.944	1.95E-03	ATF5,DDIT3,HMOX1,HSPA5,HSPD1,HSPE1,NFE2L2,SARS,TENM4,TRIB3,WARS,XPOT	CEBPA,CEBPB,DDIT3,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,STAT3	
P3	 	hexachlorobenzene	 	chemical toxicant	Activated	3.450	bias	0.610	 	1.95E-03	ANXA1,ANXA2,ASNS,CD14,FCGR2A,GAS5,MMP9,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A	CTNNB1,EGFR,ERK1/2,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,estrogen receptor,hexachlorobenzene	
P3	 	rotenone	 	chemical toxicant	 	0.044	 	-0.055	0.232	1.95E-03	ATF4,BSG,CYBB,DDIT3,FOS,HIF1A,HMOX1,MAPT,MMP9,SLC16A1,UCP2,VCAM1	AGT,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SREBF1,STAT3,TP53,fatty acid,hydrogen peroxide,rotenone	
P3	 	SBDS	1.673	other	 	 	 	 	 	1.96E-03	AKR1C1/AKR1C2,AKR1C3,CHAC1,COL27A1,CRYM,CTGF,DDIT3,EGR1,FOS,HSP90AB1,HSPA5,KIF1A,PCDH7,PSMD7,SPP1,TRIB3	CEBPB,DDIT3,MTPN,NFKBIA,NFkB (complex),RELA,SBDS	
P3	 	NEDD9	-1.988	other	 	1.414	bias	0.669	 	2.02E-03	APP,FOS,GDF15,KIT,MKNK2,MMP9,PCK1,PLIN2,PLOD2	ARNT,Akt,ERK,FOS,HIF1A,IL2,JUN,NEDD9,NFKB1,NFkB (complex),NR3C1,PPARG,RELA,RNA polymerase II,SP1,SRC,STAT3,STAT5B,TP53	
P3	 	XDH	-1.956	enzyme	 	-0.213	 	-0.101	0.090	2.02E-03	CEBPB,CTGF,CYBB,DUSP1,DUSP10,HIF1A,MMP14,PLAU,SPP1	CTNNB1,EGFR,ERK1/2,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,XDH,estrogen receptor	
P3	 	etoposide	 	chemical drug	 	0.563	bias	0.333	-0.980	2.02E-03	ADAM17,BCL2L1,BIN1,CREG1,CTSD,CYCS,DUSP1,DUSP4,EEF1A1,EEF1B2,FAS,FTH1,GDF15,HK1,NR4A1,PEBP1,PFKL,RHOBTB2,SEPT9,SQSTM1,TAF6,TNFRSF1A,TOP2A,TP63	CTNNB1,E2F1,ERK,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RB1,RELA,RNA polymerase II,SP1,STAT3,TP53,etoposide	
P3	 	simvastatin	 	chemical drug	 	-1.192	 	-0.162	-0.469	2.04E-03	ADCYAP1R1,ANXA1,APOB,APP,ARHGDIA,ARHGEF2,BCL2L1,C12orf10,CCND2,CD14,CTGF,CYBB,CYR61,FOS,HK1,HMOX1,IGFBP3,ITGB2,KIT,KLF2,MKI67,MMP9,PLAT,SDC4,SOCS3,SPP1,ST6GALNAC4,TIMM10,VCAM1	CEBPA,CEBPB,CSF3,IGF1,IL1B,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,STAT5B,simvastatin	
P3	 	fluocinolone acetonide	 	chemical drug	 	-0.302	 	-0.106	0.049	2.05E-03	ANOS1,BCL2L1,FKBP5,HSD11B2,LIMCH1,MYOC,PCDH19,PIR,SAA1,SOCS3,ZBTB16	EP300,JUN,NFkB (complex),NR3C1,RELA,TP53,fluocinolone acetonide	
P3	 	Vegf	 	group	Activated	2.647	bias	0.519	 	2.06E-03	ALOX5AP,ASNS,BIRC7,CALCRL,CALM1 (includes others),CDC42,CHI3L1,CPA3,CSE1L,CXCL12,CYP4A11,CYR61,DDIT3,DKC1,DOK5,DUSP4,DUSP6,EGR1,EMP1,ETV5,FAS,FKBP5,FLNA,FOSB,FST,GEM,GJB2,GNA13,HIF1A,HMOX1,IGFBP3,IGFBP4,LPAR1,LRP8,MAP2K3,MAPKAPK2,MKI67,MMP9,MPC1,NAB2,NID2,NPL,NR4A1,NR5A2,PDGFA,PHLDA2,PLAU,PLOD2,PPP1R1B,PVR,RNF187,SFRP1,SLC20A1,SLC7A1,SLC7A2,SOCS3,TACR1,UGCG,VCAM1	CTNNB1,FOS,HIF1A,HRAS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RAF1,RELA,SP1,STAT3,TGFB1,TP53,Vegf	
P3	 	2-[[4-[(e)-styryl]phenoxy]methyl]oxirane	 	chemical reagent	 	 	 	 	 	2.06E-03	APOE,NR1H3,SREBF1	 	
P3	 	ATP2A1	-5.017	transporter	 	 	 	 	 	2.06E-03	CALR,DDIT3,HSPA5	 	
P3	 	CYP	 	group	 	 	 	 	 	2.06E-03	GCLM,HMOX1,NQO1	AHR,CYP,DDIT3,EP300,NFE2L2,NFKBIA,NFkB (complex),RELA,STAT3,TP53,acetaminophen,benzo(a)pyrene,carbon monoxide	
P3	 	ENPP1	-1.341	enzyme	 	 	 	 	 	2.06E-03	ALPL,LEP,SPP1	 	
P3	 	MAF1	1.413	other	 	 	 	 	 	2.06E-03	ACTB,MT-TY,NNMT	 	
P3	 	RRM2	-1.033	enzyme	 	 	 	 	 	2.06E-03	HIF1A,MMP9,THBS1	ELK1,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,RRM2,SP1,STAT3,TP53,nitric oxide	
P3	 	asparagine	 	chemical - endogenous mammalian	 	 	 	 	 	2.06E-03	ASNS,OAZ1,ODC1	 	
P3	 	ticrynafen	 	chemical drug	 	 	 	 	 	2.06E-03	GCLM,HMOX1,NQO1	 	
P3	 	NPC1	1.256	transporter	 	0.144	bias	-0.344	1.094	2.08E-03	ATF4,CD68,CTSB,CTSD,CYP27A1,DDIT3,LIPA,MMP14,SCD,SREBF2	25-hydroxycholesterol,APP,FOS,HIF1A,JUN,NFE2L2,NFKB1,NFkB (complex),NPC1,PPARA,PPARG,RELA,SREBF1,SREBF2,TP53,cholesterol,fatty acid	
P3	 	isoproterenol	 	chemical drug	 	1.408	bias	0.450	-0.602	2.11E-03	ACSL3,ADIPOQ,APP,CYP1B1,FOS,HMOX1,JUNB,LEP,MMP9,NR4A1,ODC1,PCK1,PDGFA,PLAT,PLIN2,PLP1,PRNP,RAB5C,RAB7A,SCD,TUBB,UCP2	CEBPB,CREB1,CREBBP,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,cyclic AMP,fatty acid,forskolin,isoproterenol	
P3	 	HMOX1	4.313	enzyme	 	0.474	 	-0.046	0.652	2.12E-03	ADIPOQ,BCL2L1,CD14,CXCL12,FGF1,FOS,HMOX1,IL1RN,MAPT,MMP9,MSR1,NFE2L2,NQO1,SLC25A5,TGFB2,THBS1,TYMP,VCAM1	Akt,CTNNB1,ERK,FOS,HMOX1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	bucladesine	 	chemical toxicant	 	1.223	bias	0.403	-1.224	2.13E-03	ANXA1,APOE,ASS1,C3AR1,CD14,CEBPB,CHST2,CNP,DGKQ,DUSP1,FCGR2A,FOS,FST,FSTL3,GDF15,GEM,GLUL,GSTP1,HMOX1,ID4,IGFBP3,IGFBP6,ITGB2,JUNB,KIT,LEP,MAT2A,MCAM,MMP14,MMP9,NCAM1,NR4A1,ODC1,PCK1,PLAU,QSOX1,SIGMAR1,SOCS3,SOX17,TGFB2	CEBPA,CTNNB1,ERK,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SP1,STAT3,TNF,TP53,bucladesine,glucocorticoid	
P3	 	ETS1	-1.056	transcription regulator	 	1.854	bias	0.499	0.242	2.17E-03	ARL4C,BCL2L1,CD14,CDK6,CSF1R,CTGF,EGR1,FCGR2A,HCST,HMOX1,HS2ST1,HSPA8,HSPB8,HSPE1,ITGB2,JUNB,LAIR1,MGAT5,MMP9,MSR1,NCLN,NQO1,PEG10,PHLDA2,PLAA,PLAU,PVR,SPP1,SZRD1,TGFB2	CREBBP,CSF2,EP300,ETS1,FN1,HIF1A,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	2-deoxyglucose	 	chemical drug	 	0.345	 	0.109	-0.009	2.28E-03	APP,ATF4,BCL2L1,BMF,DDIT3,FOS,GOT1,HIF1A,HSPA5,LEP,ODC1,SPP1	2-deoxyglucose,Akt,CEBPA,CTNNB1,FOS,FOXO1,FOXO3,HIF1A,IGF1,INS,JUN,Jnk,MYC,NFkB (complex),PPARA,RELA,SP1,SREBF1,STAT3,TP53	
P3	 	IL6ST	1.181	transmembrane receptor	 	-0.213	bias	0.468	-1.611	2.28E-03	BCL2L1,CLDN2,CSF1R,EGR1,JUNB,LTF,MAF,RET,SOCS3,TNFRSF1A,TRPA1,VCAM1	CEBPB,CTNNB1,ERK1/2,FOXO1,IL6,IL6ST,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SPI1,STAT3	
P3	 	hemin	 	chemical - endogenous mammalian	Activated	2.028	bias	0.421	0.609	2.28E-03	AKR1C1/AKR1C2,BCL2L1,CYBB,FTH1,FTL,GSTP1,HMOX1,HSP90AB1,NFE2L2,NQO1,SHC1,TXN	BACH1,CEBPA,HMOX1,JUN,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,RELA,SHC1,SP1,TNF,TP53,hemin,hydrogen peroxide	
P3	 	ursolic acid	 	chemical drug	Inhibited	-2.750	bias	-0.338	-1.820	2.28E-03	AKR1B1,BCL2L1,EIF2S2,FOS,GDF15,LEP,MARS,MKI67,MMP9,NARS,SARS,VCAM1	Akt,CTNNB1,FOS,HIF1A,IL1B,JUN,Jnk,MTOR,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SIRT1,SP1,STAT3,TP53,ursolic acid	
P3	 	YY1	1.301	transcription regulator	Activated	2.778	 	0.057	2.620	2.28E-03	ALCAM,ATF4,BCL2L1,BMP6,BTG2,CALR,CAPG,CBX3,CFTR,COL15A1,CXCL12,CYBB,EEF1B2,EIF4G2,FAS,FOS,GBP1,GPC3,HMOX1,HSPA5,ID4,KIF5B,MAT2A,MKI67,MYH1,PDGFA,PNRC2,PROX1,RPL30,SIM1,TGFB2,TOP2A,UNG,WSB1	CDKN2A,CEBPB,CREBBP,ELK1,EP300,ESR1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,SP1,STAT3,TP53,YY1	
P3	 	IFRD1	1.590	other	 	-1.348	bias	-0.379	-0.288	2.29E-03	CTGF,DES,DGAT2,HK1,LAMA2,NDUFA6,PPIA,SPP1	CTNNB1,IFRD1,JUN,NFkB (complex),STAT3,TCF7L2,TP53	
P3	 	BARX2	-7.363	transcription regulator	 	0.555	bias	0.592	 	2.36E-03	ANLN,DYNLL1,FLNA,HSPA9,MMP9,NCAM1	 	
P3	 	GPER1	1.324	g-protein coupled receptor	 	-1.670	bias	0.543	 	2.36E-03	CTGF,EGR1,FOS,HSPA5,LTF,SFRP2	ADIPOQ,ERK1/2,ESR1,ESR2,GPER1,HIF1A,IL6,JUN,MAP2K1,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SP1,STAT3,beta-estradiol	
P3	 	Ras	 	group	 	1.095	bias	0.452	-0.488	2.38E-03	ARHGEF2,BCL2L1,CCND3,CDK6,CTGF,EGR1,FOS,GSTP1,HMGA1,HMOX1,MMP9,NPM1,ODC1,PDGFA,PLAU,PRDX1,PSMD10,PVR,SERPINE2,SREBF1	CEBPB,CREBBP,CTNNB1,Creb,ELK1,ERK,ESR1,FOXO1,FOXO3,JUN,MAP2K1/2,MKL1,NFKB1,NFKBIA,NFkB (complex),RELA,Ras,Ras homolog,SP1,STAT3,TP53	
P3	 	P1,P4-Di(adenosine-5') tetraphosphate	 	chemical - endogenous mammalian	 	1.131	bias	0.710	 	2.41E-03	KIT,TGFB2,THBS1,TPSAB1/TPSB2	MITF,P1,P4-Di(adenosine-5') tetraphosphate,SPI1	
P3	 	acetic acid	 	chemical - endogenous mammalian	 	-1.955	bias	0.533	 	2.41E-03	EGR1,FOS,JUNB,LEP	ERK,JUN,NFkB (complex),RELA,SP1,STAT3,acetic acid	
P3	 	allyl isothiocyanate	 	chemical toxicant	 	 	 	 	 	2.41E-03	FOS,HMOX1,MMP9,NFE2L2	ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT3,allyl isothiocyanate	
P3	 	aplidine	 	biologic drug	 	-1.103	bias	0.533	 	2.41E-03	DUSP1,FOS,FOSB,JUNB	CTNNB1,EGFR,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,SRC,STAT3,aplidine,estrogen receptor	
P3	 	GDNF	-8.285	growth factor	Inhibited	-2.133	bias	0.308	-2.989	2.42E-03	ACTB,CLDN5,CTSB,EGR1,FOSB,GNB1,HSD11B2,KIT,PPP1R1B,PRKACA,RPS4Y1,RPSA,SCN11A	AKT1,ERK1/2,FOXO1,FOXO3,GDNF,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,RET,SP1,STAT3,TP53	
P3	 	GNA15	1.430	enzyme	 	 	 	 	 	2.44E-03	AKR7A2,CYCS,DAB2,DDIT3,FHL1,FMO1,GLUL,HMOX1,MAT2A,MYH1,NEXN,ODC1,PLAT,SLC6A6,SLC7A1,TRIB3,UNC5B	CHUK,CTNNB1,FOS,GNA15,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P3	 	arotinoid acid	 	chemical toxicant	 	1.287	bias	0.401	0.245	2.45E-03	DUSP1,FOLR2,FOS,ODC1,PLTP,SCD,SOX9	CEBPA,CTNNB1,EGF,EGFR,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,arotinoid acid,estrogen receptor	
P3	 	MKL1	-1.260	transcription regulator	 	-0.981	 	-0.142	-0.424	2.47E-03	ACTB,ARPC1B,ARPC4,BCL2L1,CD151,CMA1,COMT,COX7A1,CPA3,CTSG,EGR1,FLNA,FOS,G0S2,GSTM5,HLA-A,LTF,MMP9,MYL9,OSCP1,SLC20A1	Akt,CASP8,CTNNB1,JUN,MKL1,NFKB1,NFkB (complex),RELA,Ras,SP1,STAT3,TP53	
P3	 	EGR3	1.101	transcription regulator	 	0.000	 	0.061	-0.172	2.48E-03	B3GALT6,BCL2L1,EFNB1,IRAK1,NAB2,PLXND1,RET,SOCS3,SOX9	CEBPB,CTNNB1,EGR3,FOXO1,NFKB1,RELA,STAT3	
P3	 	conjugated linoleic acid	 	chemical drug	 	0.137	 	0.051	0.005	2.48E-03	DUSP1,FOS,GDF15,IL10RA,IL1RN,ITGB2,LEP,MMP9,SOCS3	CEBPB,CTNNB1,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNFSF11,TP53,conjugated linoleic acid	
P3	 	LDLR	-1.034	transporter	 	1.396	 	-0.135	1.769	2.49E-03	ALCAM,APOB,APOE,CD68,CYP27A1,DDIT3,EGR1,HSPA5,MMP14,MMP9,MSR1,NR1H3,PSMB7,SPP1,SREBF1,VCAM1	APOE,CEBPA,CTNNB1,Creb,LDL,LDLR,MAPKAPK2,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SP1,SREBF1,SREBF2,STAT3,TNF,cholesterol	
P3	 	ABCA1	1.658	transporter	 	-0.883	 	-0.142	-0.476	2.50E-03	ADIPOQ,ANXA1,APOB,APOE,APP,DGAT2,HSPA5,LEP,SREBF1,SREBF2	ABCA1,APOE,CTNNB1,IL1B,IL6,Insulin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,SREBF2,STAT3,cholesterol	
P3	 	FGF21	1.657	growth factor	 	0.017	bias	0.281	-0.855	2.50E-03	ADIPOQ,CIDEA,COX7A1,DGAT2,EGR1,FGFR2,LEP,ME1,PCK1,SREBF1	ADIPOQ,AMPK,CEBPA,CEBPB,FGF21,FOXO1,FOXO3,IGF1,Ins1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SIRT1,SP1,SREBF1,STAT3,TP53	
P3	 	diethylstilbestrol	 	chemical drug	 	0.172	bias	0.299	-1.281	2.50E-03	ADIPOQ,ADM2,ALPL,BCAT1,C1QA,CD14,CLSTN2,DCLK1,DUSP6,EGR1,EMP1,ESR2,FAS,FMO1,FOS,GJB2,GSPT1,GSTM3,HLA-A,HOXA10,HSP90AB1,IGFBP3,IGFBP6,IGSF6,KLF4,LMO4,LTF,PDGFA,RPN2,TP63	CASP8,CTNNB1,Creb,ERK1/2,ESR1,ESR2,FOXO1,FOXO3,HMGA1,IRS1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,diethylstilbestrol,estrogen receptor,testosterone	
P3	 	MTPN	1.921	transcription regulator	 	1.983	bias	0.710	 	2.52E-03	ANXA1,BCL2L1,CCND2,CCND3,COL8A1,FAS,FOS,GAS5,MTPN,MYH1,PLAT,SPP1,TGFB2,TNFRSF1A,VCAM1	JUN,MTPN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P3	 	NFYA	1.320	transcription regulator	Activated	2.137	bias	0.521	 	2.52E-03	CALR,CDC42,COL5A3,EGR1,EPHX1,F8,FGFR2,FTH1,HSPA5,JUNB,MLH1,PKM,SCD,THRSP,TOP2A	 	
P3	 	SMARCA4	1.793	transcription regulator	Activated	3.478	bias	0.648	 	2.52E-03	ADIPOQ,ARL4C,ARRDC4,ASNS,ATG9A,BIN1,BIRC7,CCDC85B,CD52,CD63,CDH11,CEBPB,CNP,CPM,CSF1,CTGF,CTSB,CTSS,CYP4B1,DES,DGKG,DHRS9,DUSP4,DUSP6,EFNB1,EGR1,FADS3,FAS,FCGR2A,FGFR2,FOS,GAPDH,GBP1,GSTP1,GULP1,GYS1,HCST,HOXA7,IFI30,IGFBP4,IL20RB,ITGAV,KIFC3,KIT,KLF8,MAP1B,NFKBIZ,PHLDA2,PLAT,PLIN2,PTP4A2,PTX3,RAB38,SEMA3B,SERPINE2,SERPINH1,SMARCA4,SOX17,SPP1,SRPX,ST6GALNAC4,STXBP6,TGFB2,TREM2,TUBB,TWF1,TXNRD1	CEBPB,CREBBP,CTNNB1,ELK1,ESR1,ESR2,FOXO1,MYC,NFKB1,NFKBIA,RELA,RNA polymerase II,SMARCA4,SP1,STAT3,TP53	
P3	 	NKX2-1	-16.129	transcription regulator	 	0.218	bias	0.323	-0.627	2.62E-03	ADCYAP1,BTG3,CD14,CYGB,EDIL3,EPHB3,FARSB,HLA-A,HS2ST1,IGFBP6,LYZ,MAPT,PLP1,QSOX1,RET,ROR1,SCARA3,SCD,SCN7A,SOX17,SREBF2,TGFB2,THBS1,TP63,TPO,WNT5B	 	
P3	 	romidepsin	 	biologic drug	 	-0.042	 	0.112	-0.259	2.65E-03	BCL2L1,CDC42,DDIT3,DDX21,DUSP1,DUSP6,EGR1,FOS,HIF1A,ITGAV,MLH1,MMP9	Creb,ELK1,ERK1/2,FOXO1,FOXO3,MAP2K1/2,MYC,Mek,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TP53,romidepsin	
P3	 	DAP3	1.264	other	Inhibited	-2.236	bias	0.710	 	2.71E-03	MT-ATP6,MT-CO1,MT-CYB,MT-ND1,MT-ND5	 	
P3	 	TMBIM6	1.825	other	 	0.200	 	0.055	0.080	2.71E-03	DDIT3,EDEM1,HMOX1,HSPA5,SEC61A1	ATF6,DDIT3,ERN1,NFkB (complex),TMBIM6,XBP1	
P3	 	clenbuterol	 	chemical drug	 	-0.152	bias	0.355	-0.856	2.71E-03	BCL2L1,IL1RN,MYH1,SLC16A1,SOCS3	Akt,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,clenbuterol	
P3	 	ladostigil	 	chemical drug	 	 	 	 	 	2.71E-03	ALDOC,APP,BCL2L1,TFRC,YWHAG	APP,HIF1A,JUN,NFKB1,NFkB (complex),Pkc(s),RELA,STAT3,TP53,ladostigil	
P3	 	leupeptin	 	chemical - protease inhibitor	Activated	2.200	bias	0.592	 	2.71E-03	APP,CD151,GBA,HRAS,MAPT	APP,HIF1A,NFKB1,NFkB (complex),RELA,TP53,leupeptin	
P3	 	nelfinavir	 	chemical drug	 	1.467	bias	-0.382	2.302	2.71E-03	ADIPOQ,ATF4,DDIT3,MMP9,PLIN1	AKT1,Akt,CTNNB1,FOXO1,JUN,MMP9,NFKB1,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,fatty acid,nelfinavir	
P3	 	GLI1	-1.311	transcription regulator	 	1.957	bias	0.577	 	2.78E-03	ARPC5,BCL2L1,CCND2,CDH11,CSF1,DEGS1,FAS,FHL1,FUCA2,GPC3,IGFBP6,KLF4,MLH1,MMP9,MRPS6,NQO2,PCDH18,PDGFA,PHLDA2,PRKCE,PVR,RPL30,SESN3,SFRP1,SH2B3,SH3GLB1,SOX9,SPP1	CTNNB1,GLI1,JUN,MYC,NFE2L2,NFKBIA,NFkB (complex),PML,RELA,SP1,STAT3,TCF7L2,TP53,arsenic trioxide	
P3	 	PTPN11	1.299	phosphatase	 	-1.318	 	0.109	-1.637	2.78E-03	BCL2L1,BSG,CD14,CD68,CSF1,CSF1R,CYBB,EGR1,FOS,KIT,LTF,SOCS3,TP63	FOXO3,GATA1,IL6,IL6ST,IRF8,JUN,LEP,NFKB1,NFkB (complex),PPARG,PTPN11,RELA,RNA polymerase II,RUNX1,SP1,SPI1,STAT3,STAT5B,TP53	
P3	 	CSF2	-1.733	cytokine	Activated	4.121	bias	0.549	 	2.78E-03	ALOX5AP,ANLN,ANXA1,BCL2L1,BSG,CCND3,CD14,CD209,CD28,CD63,CD83,CHST11,COL8A1,CSF1,CSF1R,CYBB,DDIT3,DUSP6,EGR1,FAS,FOLR2,FOS,GCLM,GDF15,HSPD1,HSPH1,IL1RN,LAMP2,LCP1,LEP,MAT2A,MKI67,MLH1,MMP14,MMP9,NR1H3,NR4A1,ODC1,PLAU,PPIF,PRNP,QSOX1,RRM2B,SLC1A5,SMPD2,SNTB1,SOCS3,SPP1,SQSTM1,STEAP3,THBS1,TNFRSF1A,TOP2A,UTP11	CEBPA,CEBPB,CSF2,Creb,ELK1,IFNG,IL6,JUN,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TNF,TP53	
P3	 	MAPK9	1.567	kinase	Activated	2.179	bias	0.298	0.969	2.82E-03	CEBPB,EGR1,FOS,GAPDH,HIF1A,HMGA1,JUNB,LSM3,MARCKSL1,METAP2,MMP9,NME2,NR1H3,PLAT,PLIN2,PTX3,RAD23B,RILPL1,RPSA,SCD,SERPINA1,SREBF1,THRA	CEBPA,CEBPB,CTNNB1,ERK1/2,FOXO1,IL1B,MAPK9,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	Gm-csf	 	group	 	-0.160	bias	0.606	 	2.85E-03	BCL2L1,CCND2,CD14,CD209,CD83,FAS,FOS,IRAK1,JUNB,MMP9,SOCS3	Akt,CASP8,CTNNB1,ERK1/2,Gm-csf,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3	
P3	 	2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine	 	chemical toxicant	Activated	3.162	bias	0.575	 	2.98E-03	CCT4,CCT5,CCT7,HSPA5,HSPA8,HSPD1,HSPE1,HSPH1,PSME1,RAN	 	
P3	 	RBM5	1.115	other	 	-1.941	bias	-0.268	-1.105	2.98E-03	ADAM9,ANXA1,ATP6V0C,BTG2,GBE1,ITPA,MLH1,RAB1A,SERPINH1,UCP2	 	
P3	 	PP1	 	chemical - kinase inhibitor	 	-1.644	bias	-0.403	-0.452	3.01E-03	BCL2L1,CCND2,CXCL16,FOS,HMOX1,IL1RN,ODC1,SIRPA,VCAM1	CTNNB1,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PIK3R1,PP1,RELA,SP1,SRC,STAT3,TP53	
P3	 	4-hydroxytamoxifen	 	chemical drug	 	-0.128	bias	0.264	-1.337	3.03E-03	BCL2L1,CAPNS1,CEBPB,CHST2,CNBP,COL16A1,CTSD,DDX21,DYNLL1,EIF5A,FOS,GM2A,IGFBP3,JUNB,MKI67,MPC1,OGT,PDCD5,RHOBTB2,TMOD1,TNPO1,TRIM16	4-hydroxytamoxifen,CEBPA,ERK1/2,ESR1,ESR2,FOXO1,IGF1,IGF1R,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT3,STAT5B,TP53,estrogen receptor	
P3	 	phenylbutazone	 	chemical drug	Activated	2.967	bias	0.544	 	3.07E-03	ANXA1,ANXA2,ASNS,CAPN6,FCGR2A,GAS5,GSTM3,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	androgen	 	chemical drug	 	0.093	 	-0.015	0.147	3.09E-03	ADAMTS15,AES,AKR1C3,BMP6,BTG2,CA12,CALR,CCND3,CTSB,FGFR2,FLNA,FOS,MMP9,NR4A1,NR6A1,PARK7,PTP4A2,PTPRC,PTPRK,RET,SDC4,SFRP2,SOX9,STIM1	CTNNB1,ERK,FOS,JUN,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),PRL,Pkc(s),RELA,SP1,SRC,STAT3,STAT5B,TP53,androgen	
P3	 	fatty acid	 	chemical - endogenous mammalian	 	0.861	bias	0.510	 	3.14E-03	CIDEA,CYR61,DDIT3,HMOX1,HSPA5,LPIN2,MMP9,NR1H3,NR4A1,PLIN2,PLIN5,SCD,SREBF1,THRSP,UCP2,VCAM1	CEBPA,CEBPB,FOXO1,Insulin,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,Pkc(s),RELA,RXRA,SP1,SREBF1,STAT3,fatty acid,palmitic acid	
P3	 	rimonabant	 	chemical drug	 	-1.977	bias	-0.312	-1.167	3.16E-03	ADIPOQ,CNR1,FOS,HSPA5,IL1RN,MMP9,SREBF1	AMPK,CEBPB,CREBBP,ERK1/2,FOXO3,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,PPARGC1A,RELA,SIRT1,SP1,STAT3,STAT5B,TP53,cyclic AMP,rimonabant	
P3	 	sorafenib	 	chemical drug	 	-1.939	 	-0.237	-1.343	3.16E-03	BCL2L1,CCND2,CCND3,CDK6,DDIT3,HIF1A,HSPA5	Akt,CEBPB,ERK1/2,JUN,KIT,MITF,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53,bortezomib,sorafenib	
P3	 	allopurinol	 	chemical drug	Activated	2.840	bias	0.440	1.138	3.20E-03	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GAS5,GSTM3,HMOX1,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	1-methyl-4-phenylpyridinium	 	chemical toxicant	 	0.913	bias	0.411	-0.070	3.21E-03	ATF4,DDIT3,HIF1A,SOD1,TFRC,TRIB3	1-methyl-4-phenylpyridinium,ERN1,HIF1A,HTT,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,RXRA,SNCA,STAT3,VHL,XBP1,iron	
P3	 	SP100	-1.135	transcription regulator	 	 	 	 	 	3.21E-03	CD14,CTGF,HSPA8,HSPB8,HSPE1,PLAU	EP300,ETS1,RNA polymerase II,SP100,TP53	
P3	 	hydroxypropyl-beta-cyclodextrin	 	chemical drug	 	-1.673	bias	-0.262	-1.048	3.21E-03	CD68,CTSB,CTSD,LIPA,SQSTM1,SREBF2	 	
P3	 	leuprolide	 	biologic drug	 	-0.970	 	0.079	-1.161	3.21E-03	APP,EGR1,MMP14,MMP9,NR4A1,PEA15	AKT1,CTNNB1,FOXO1,MMP1,MMP9,NFKB1,NFkB (complex),NR4A1,RELA,SP1,TP53,leuprolide	
P3	 	vitamin K2	 	chemical drug	Activated	2.425	bias	0.635	 	3.21E-03	AKR1C1/AKR1C2,CD14,COL6A1,CSF1,MATN2,SPP1	 	
P3	 	GAST	-2.945	other	Activated	2.366	bias	0.578	 	3.23E-03	ANXA7,ATF4,EGR1,FOS,IMPDH2,MDH2,MMP9,NARS,ODC1,PHB,POR,RPS19,SLC4A2,VCAM1	CREB1,ELK1,ERK,FOS,GAST,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PRKCA,PRKCE,RELA,SP1,SREBF1,STAT3	
P3	 	3-nitropropionic acid	 	chemical toxicant	 	1.596	 	0.142	1.203	3.33E-03	APP,ATP6V1B2,BCL2L1,CNR1,GAPDH,GSK3B,MMP9,NQO1,PPP1R1B,SLC7A11,SQSTM1	3-nitropropionic acid,APP,BACH1,CTNNB1,FOS,FOXO3,HIF1A,HTT,JUN,Jnk,KEAP1,NFE2L2,NFKB1,NFkB (complex),PPARG,RELA,SP1,STAT3,TP53	
P3	 	capsaicin	 	chemical drug	 	1.394	 	-0.065	1.595	3.33E-03	ABCC3,ATF4,DDIT3,FOS,GDF15,HMOX1,LEP,MMP14,MMP9,TACR1,TGFB2	Akt,CEBPA,CREB1,CTNNB1,Creb,ERK,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,capsaicin,norepinephrine	
P3	 	iron	 	chemical - endogenous mammalian	 	1.429	 	0.091	1.174	3.33E-03	APP,BMP6,CCND2,CCND3,CSNK2B,DDIT3,FTH1,FTL,HIF1A,HMOX1,TFRC	Akt,CTNNB1,EPAS1,ETS1,FOXO3,HIF1A,IL6,JUN,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,VHL,caspase,iron	
P3	 	MITF	1.633	transcription regulator	Activated	3.836	bias	0.637	 	3.36E-03	ACO2,ALCAM,APEX2,APOE,ATP6V1B2,BIRC7,CD151,CLCN7,CMA1,CTSG,EDNRB,FOS,GM2A,GYG2,HIF1A,HMBS,HPGDS,INPP4B,KAZN,KIT,MBP,MGAT4B,MMP14,OSTM1,PIR,RRAGD,SOX9,ST3GAL6,STXBP1,TBC1D16,TPSAB1/TPSB2,VAT1	GATA1,IRF8,JUN,MITF,RUNX1,SPI1,TP53	
P3	 	KIT	2.275	transmembrane receptor	 	 	 	 	 	3.51E-03	BCL2L1,BIRC7,C3AR1,CCND2,CCND3,CD53,CD63,CMA1,CPA3,HMOX1,KIT,PPP2R1A,RAB32,SHC1,SOCS3,SPP1	Akt,CEBPA,FOS,JUN,KIT,KITLG,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RB1,RELA,SP1,STAT3,STAT5B,TNF,sorafenib	
P3	 	clozapine	 	chemical drug	 	0.728	bias	0.415	-0.552	3.54E-03	CIDEA,DVL3,EGR1,FOS,GSK3B,HDAC2,HMGCS1,NR4A1,PEA15,SCD,SREBF1,SREBF2	AKT1,CEBPB,CREB1,CREBBP,Creb,DRD1,FOXO1,HTT,Insulin,NFkB (complex),NR4A1,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,clozapine,cyclic AMP,estrogen receptor,norepinephrine	
P3	 	mitomycin C	 	chemical drug	 	1.331	bias	0.533	 	3.54E-03	BCL2L1,BTG2,CDC42,EGR1,FAS,MCAM,NQO1,PRKCE,PYCARD,SESN2,TP63,TYMP	CEBPB,CTNNB1,FOS,IFNG,Jnk,MYC,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,mitomycin C	
P3	 	4-hydroxynonenal	 	chemical toxicant	 	1.206	bias	0.331	0.346	3.55E-03	AKR1B1,AKR1C1/AKR1C2,APP,BAG3,BCL2L1,CTGF,CTSB,MMP9	4-hydroxynonenal,CDKN1A,CEBPA,CTNNB1,D-glucose,EP300,ERK1/2,FOS,HIF1A,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT3,TNF,TP53	
P3	 	Fgf	 	group	 	0.837	bias	0.596	 	3.55E-03	CCND3,FOS,GNL3,JUNB,MMP9,ODC1,SPRY4,VCAM1	Akt,ELK1,ERK,ERK1/2,FOS,Fgf,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P3	 	E. coli B4 lipopolysaccharide	 	chemical toxicant	Activated	2.937	bias	0.464	0.196	3.55E-03	ABCB11,ADAMTS5,ANXA1,B3GNT5,BCL2L1,C12orf49,C1QB,CD83,CYP27A1,F13A1,F5,FAS,FCER1G,FOSB,HLA-A,HMOX1,HSPB8,IL1RN,IMP4,LCP1,PLEK,PPP1R1B,PTPRC,PYCARD,RAB10,RAB20,SERPINH1,SOCS3,ST6GALNAC2,STAB1,STC2,TNFRSF1A,TOLLIP,TSPO,USP18,VCAM1	CEBPA,CEBPB,E. coli B4 lipopolysaccharide,IFNG,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	SB 216763	 	chemical toxicant	 	0.287	bias	0.459	-1.077	3.63E-03	CTGF,CYR61,FOSB,FSCN1,NR4A1,PCK1,PLAU,SCD,SREBF1	CEBPA,CEBPB,CTNNB1,FOXO1,IL1B,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,SB 216763,STAT3,TNF,TP53,palmitic acid	
P3	 	SREBF2	1.956	transcription regulator	 	0.714	bias	0.547	 	3.64E-03	AACS,ALDOC,HMGCS1,LIPA,MSMO1,MVD,NPC1L1,PLIN2,PMVK,SCD,SREBF1,SREBF2,THRSP	CEBPA,CEBPB,FOXO1,Ins1,NFE2L2,NFkB (complex),NRF1,PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,SREBF2,STAT3,cholesterol	
P3	 	gemfibrozil	 	chemical drug	 	1.797	bias	0.319	0.679	3.64E-03	ANXA7,APOE,APP,CNP,HADHB,MBP,NR1H3,PLP1,POR,RTN4,SCD,SOCS3,TPP1	APP,CEBPA,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,THRB,TNF,TP53,gemfibrozil	
P3	 	lithium	 	chemical drug	 	-0.383	 	0.101	-0.715	3.65E-03	ADCY1,ADCY2,ADRA2A,APP,CARM1,EGR1,FAS,FOS,ICMT,MMP9,NCAM1,RAB7A,RET,TACR1	ADRA1,CEBPB,CTNNB1,ERK,FOXO1,FOXO3,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,lithium	
P3	 	NUPR1	3.541	transcription regulator	 	1.313	 	-0.209	2.907	3.70E-03	ALDOC,ALG8,B3GAT3,B3GNT5,C9orf91,CD63,CD68,CEBPB,CEP170B,CYB5B,CYR61,CYSTM1,DDIT3,FAM162A,FGF1,GAB2,GABBR1,GCNT2,GDF15,HLTF,HOXB5,HSPA2,KLF4,LHFPL2,LOC102724428/SIK1,LRP8,MAFG,MAT2A,MEGF9,MKI67,NEMP1,NR1D1,NRBF2,NRSN2,NUPR1,P4HA2,PEA15,PFKFB3,PPFIBP2,PRKACA,PRNP,PXDC1,RAB20,RAB32,RAB38,SESN2,SIGMAR1,SLC6A6,SPATS2L,TESK1,TOLLIP,TRIB3,TRIM16,TSC22D2,UBIAD1,UNC5B,VANGL1,ZNF483,ZPR1	 	
P3	 	N-acetyl-L-cysteine	 	chemical drug	Inhibited	-3.340	bias	-0.373	-1.441	3.72E-03	ATF4,BSG,CCND2,CFTR,CTGF,CYBB,CYR61,DDIT3,EGR1,FAS,FOS,GCLM,GLB1,GNL3,GSTP1,HIF1A,HMOX1,HSPA5,LEP,MMP9,MSR1,NFE2L2,NQO1,OSGIN1,PLAU,SLC16A1,SPP1,VCAM1	Akt,CTNNB1,FOS,JUN,Jnk,N-acetyl-L-cysteine,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),Pkc(s),RELA,SP1,STAT3	
P3	 	INSIG1	1.037	other	Inhibited	-3.014	bias	-0.695	 	3.75E-03	AACS,ALOX5AP,APOE,CD68,ELOVL1,HMGCS1,IRF8,LIPA,LPCAT3,NFKBIZ,PCYT2,PLIN2,PMVK,SCD,SREBF1,SREBF2,UCP2	INSIG1,NFE2L2,NFkB (complex),PPARG,PPARGC1A,RELA,SREBF1,SREBF2,cholesterol	
P3	 	CDKN2A	-2.351	transcription regulator	 	-1.099	 	-0.074	-0.683	3.77E-03	AK1,BTG2,BTG3,CAPG,CCND3,CCNI,CEBPB,CTGF,CXCL14,DUSP1,EEF1A1,EGR1,FOS,FST,GABARAP,GLB1,GNA13,GNL3,GSPT1,HACD3,ITGAV,MKI67,NPM1,ODC1,P4HA2,PDGFA,POLD2,PSMA5,PTX3,RRM2B,SAE1,SOX17,TNFRSF1A,TP63,TPP1,TRIM28	CDKN1A,CDKN2A,EP300,ERK,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P3	 	CDKN1A	-2.030	kinase	 	0.832	 	-0.195	1.611	3.80E-03	ACTB,ANLN,APP,BCL2L1,CCND3,CPA3,CTGF,CTSB,CYR61,DUSP1,FAS,GLB1,GRN,H2AFZ,HSPA5,ITGAV,KNSTRN,LIMA1,MAF,MKI67,MMP9,NPM1,P4HA1,PSAP,PTPRC,SAA1,SHC1,SOX9,TOP2A,XRCC6	CDKN1A,CTNNB1,ERK1/2,FOS,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	CSF3R	-2.076	transmembrane receptor	 	 	 	 	 	3.93E-03	CD14,CXCL12,FOS,LTF,LYZ	Akt,CEBPB,CSF3R,CTNNB1,FOS,FOXO1,JUN,Jnk,NFKB1,NFkB (complex),RELA,SP1,STAT3	
P3	 	actinonin	 	chemical reagent	Activated	2.236	bias	-0.710	 	3.93E-03	MT-ATP6,MT-CO1,MT-CYB,MT-ND1,MT-ND5	 	
P3	 	bisindolylmaleimide	 	chemical - kinase inhibitor	 	0.563	bias	-0.546	 	4.02E-03	CTGF,EGR1,FOS,GFPT1,NR4A1,PCK1,PRDX1	CREB1,CREBBP,CREM,Creb,ELK1,EP300,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PRKCA,Pkc(s),RELA,RNA polymerase II,STAT3,TP53,bisindolylmaleimide	
P3	 	irbesartan	 	chemical drug	 	-1.238	bias	-0.355	-0.319	4.02E-03	ADIPOQ,FHL1,FOS,HRAS,ITGAV,LEP,VCAM1	FOXO1,HIF1A,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,irbesartan,reactive oxygen species	
P3	 	8,9-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.000	bias	0.394	-1.789	4.05E-03	ADIPOQ,MMP9,NME1,PLAT	8,9-epoxyeicosatrienoic acid,Insulin,PPARA,PPARG,RELA,SP1,SREBF1	
P3	 	AP3B1	1.069	transporter	 	 	 	 	 	4.05E-03	AP3D1,CD63,LAMP2,TNFRSF1A	 	
P3	 	Ck2	 	complex	 	0.068	 	0.079	-0.087	4.05E-03	ATF4,BCL2L1,CYBB,FOS	APP,CDKN2A,Ck2,EP300,FGF2,FOXO3,GATA1,HIF1A,JAK2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,STAT5B,TP53,YY1	
P3	 	PTGES3	1.395	enzyme	 	0.594	bias	0.552	 	4.05E-03	ABCC3,CTSD,HIF1A,NUPR1	AHR,ESR1,NFkB (complex),PTGES3,RELA,SP1,TP53	
P3	 	SLC18A2	1.667	transporter	 	0.000	 	0.237	-0.473	4.05E-03	ADCY1,DYNLL1,PSAP,TACR1	 	
P3	 	desoxycorticosterone	 	chemical - endogenous mammalian	 	0.900	bias	0.533	 	4.05E-03	CTGF,CYBB,FOS,SPP1	CTNNB1,JUN,NFKB1,NFkB (complex),PRL,Pkc(s),RELA,SP1,STAT3,STAT5B,TP53,desoxycorticosterone	
P3	 	thyroid hormone	 	chemical - endogenous mammalian	 	-0.578	 	-0.018	-0.516	4.15E-03	APOE,ATF4,ATP5L,BTG2,CCNI,COMT,COX7A1,CRAT,DAD1,EGR1,FOS,HSP90AB1,IGFBP3,IGFBP4,LEP,MBP,ME1,NHLH1,PCK1,PGD,PHYH,SERPINE2,SREBF2,THRSP,UCP2,UQCR10	APOE,Akt,CTNNB1,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RB1,RELA,RXRA,SP1,STAT3,STAT5B,THRB,TSH,thyroid hormone	
P3	 	H89	 	chemical - kinase inhibitor	 	-0.244	bias	-0.483	1.803	4.18E-03	ADIPOQ,APP,BCL2L1,CD14,CD83,CEBPB,DUSP1,EGR1,FOS,GSTP1,HMOX1,MMP9,NR4A1,PLAU,PPP1R16B,SHC1,SIGMAR1,TXN,UCP2,VCAM1	CEBPA,H89,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,Pkc(s),RELA,SP1,SREBF1,STAT3,TNF,TP53	
P3	 	ERK1/2	 	group	 	0.183	bias	0.438	-2.140	4.24E-03	ADIPOQ,AKR1C3,BCL2L1,CALR,CCND2,CEBPB,CTGF,CTSB,CYBB,DUSP1,DUSP4,EGR1,ENO1,ESR2,FGFR2,FKBP5,FOS,FOSB,HIF1A,HLA-A,HMGA1,HSPA5,IGFBP3,JUNB,MMP9,PLAU,PSMB10,PSMB6,SLC12A7,SOCS3,SOX9,SPP1,SPRY4,TACR1,TYMP,VCAM1	CEBPA,CTNNB1,EGFR,ERK1/2,HIF1A,IGF1,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TGFB1,TP53,estrogen receptor	
P3	 	CLOCK	1.508	transcription regulator	 	 	 	 	 	4.27E-03	C1QBP,DDIT3,FKBP5,HSPH1,JUNB,KCND3,MAP2K3,MID1IP1,MIIP,MKNK2,PAFAH1B2,POMGNT1,POR,PPIF,PRELID3B,RAD23A,RAP2B,SEL1L,SLC20A1,SRR,ST6GALNAC4,TMED3	 	
P3	 	CYB5R4	1.811	enzyme	Inhibited	-2.418	bias	-0.639	 	4.27E-03	ACSL3,DDIT3,EIF2S1,HMOX1,HSPA5,SCD	CYB5R4,Insulin,JUN,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,fatty acid	
P3	 	HRG	-1.942	other	Activated	2.449	bias	0.710	 	4.27E-03	C1QA,C1QB,C1QC,CD83,CXCL14,SPP1	 	
P3	 	PD184352	 	chemical drug	 	0.811	 	-0.178	1.161	4.27E-03	BCL2L1,EGR1,FOS,HSPA5,PPP1R14B,TRMT112	CREB1,CREBBP,CREM,CTNNB1,Creb,ELK1,ERK1/2,FOS,Jnk,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD184352,RELA,RNA polymerase II,SP1,STAT3,TP53	
P3	 	Ras homolog	 	group	 	0.243	 	0.237	-0.274	4.27E-03	CTGF,EGR1,FOS,ITGAV,MMP9,PLAU	CEBPB,CTNNB1,ERK,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,Ras homolog,SP1,STAT3	
P3	 	paraquat	 	chemical toxicant	Activated	2.694	bias	0.402	1.059	4.34E-03	BCL2L1,CCDC88A,CTGF,CYBB,DIP2B,FAS,GSTP1,HMOX1,KCNMA1,KLF2,LPIN2,MMP9,NR4A1,PLCE1,PLTP,SLC7A11,SOD1,TXN	CTNNB1,ETS2,FOS,HSF1,JUN,Jnk,MYC,NFE2L2,NFKBIA,NFkB (complex),PI3K (complex),RELA,SOD1,SP1,STAT3,TP53,paraquat	
P3	 	parthenolide	 	chemical drug	 	0.106	bias	-0.318	0.882	4.35E-03	ADAMTS5,BCL2L1,CLDN5,DDIT3,HMOX1,MMP9,NFE2L2,VCAM1	CEBPB,FOXO1,HIF1A,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,STAT3,TP53,palmitic acid,parthenolide,reactive oxygen species	
P3	 	sildenafil	 	chemical drug	 	-0.863	 	-0.115	-0.542	4.35E-03	AIF1,APP,BCL2L1,CEBPB,CYBB,FGF1,HMOX1,SLC9A1	Akt,ELK1,ERK1/2,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,nitric oxide,sildenafil	
P3	 	SUZ12	1.409	enzyme	 	 	 	 	 	4.48E-03	AKR7A2,CBX6,CCPG1,CNR1,CTNNA1,EML4,HOXA10,HOXB5,IGFBP3,KLF4,LITAF,MGAT4B,PLAU,PLCB4,RAN,SLC7A5,SMARCA4,SOX17,UHMK1	EZH2,STAT3,SUZ12	
P3	 	leukotriene D4	 	chemical - endogenous mammalian	 	-0.996	bias	0.684	 	4.50E-03	ADAM12,CITED1,CYR61,DUSP1,EGR1,GEM,KLF2,KLF4,LOC102724428/SIK1,NR4A1,PLAA	NFE2L2,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,leukotriene D4	
P3	 	Akt	 	group	 	1.884	bias	0.307	0.377	4.50E-03	ATF4,BCL2L1,BMF,CCND2,CCND3,CEBPB,CIDEA,COX4I1,CTGF,CTSD,CXCL12,FAS,FOS,GSK3B,HIF1A,HMOX1,LEP,MCAM,MMP14,MMP9,MT-CO1,NFE2L2,PCK1,PEA15,PPP1R1B,PTX3,SLC4A7,SOCS3,SPP1,THBS1,VCAM1	AKT1,Akt,CEBPB,CTNNB1,ERK,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	EIF2AK2	-1.056	kinase	 	0.565	bias	0.618	 	4.52E-03	ATF4,CEBPB,DDIT3,EGR1,ERAP2,FAS,FOS,GABBR1,KCTD13,MT1M,NNMT,OAS1,PSMB10,SOCS3,USP18	Akt,CEBPB,CTNNB1,EIF2AK2,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3	
P3	 	NCOR1	1.110	transcription regulator	 	1.387	bias	-0.426	2.332	4.64E-03	ABCB11,ADIPOQ,COX8A,DUSP1,IGFBP3,LYZ,ME1,MMP9,NR1D1,PLIN1,STK39,THRSP,UQCRQ,WARS2	CEBPA,Creb,FOXO1,JUN,NCOR1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,THRB,TP53,mifepristone	
P3	 	7S NGF	 	complex	 	 	 	 	 	4.85E-03	FOS,GCLM,NFE2L2	 	
P3	 	ADRA1	 	group	 	 	 	 	 	4.85E-03	EGR1,FOS,JUNB	ADRA1,ERK,ERK1/2,ESR1,FOXO1,FOXO3,JUN,MXI1,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53	
P3	 	AR-A014418	 	chemical reagent	 	 	 	 	 	4.85E-03	BCL2L1,GDF15,MAPT	 	
P3	 	G6PC3	1.873	phosphatase	 	 	 	 	 	4.85E-03	ATF4,CYBB,DDIT3	EIF2AK3,FOXO3,G6PC3,TP53	
P3	 	GCLM	2.305	enzyme	 	 	 	 	 	4.85E-03	FOS,GCLM,JUNB	 	
P3	 	N-lauroyl-L-phenylalanine	 	chemical reagent	 	 	 	 	 	4.85E-03	KLF2,MARK1,NR4A1	 	
P3	 	PLIN2	4.938	other	 	 	 	 	 	4.85E-03	LEP,PCK1,UCP2	ATF6,CEBPA,NFkB (complex),PLIN2,PPARA,PPARG,RELA,RXRA,SREBF1,oleic acid	
P3	 	SLC16A1	2.053	transporter	 	 	 	 	 	4.85E-03	BSG,CYBB,SLC16A1	 	
P3	 	ghrelin	 	biologic drug	 	 	 	 	 	4.85E-03	EGR1,FOS,SCD	5-hydroxytryptamine,ELK1,FOXO3,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,ghrelin,nitric oxide	
P3	 	quisqualic acid	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.85E-03	EGR1,FOS,JUNB	APP,ERK1/2,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TP53,quisqualic acid	
P3	 	ruboxistaurin	 	chemical drug	 	 	 	 	 	4.85E-03	CYBB,EGR1,SREBF1	JUN,NFKB1,NFkB (complex),Pkc(s),RELA,STAT3,ruboxistaurin	
P3	 	LEPR	-1.714	transmembrane receptor	 	0.400	 	0.153	-0.185	4.95E-03	ADCYAP1,ADIPOQ,ANXA5,APOB,APOE,BCL2L1,CD63,CD68,CNR1,FOS,FYB,IGFBP3,IL1RN,LEP,LGMN,MAP4K4,MBP,MMP14,PLP1,SOCS3,SREBF1,SREBF2,STUB1,UCP2	CEBPA,CTNNB1,FOXO1,FOXO3,HMGA1,IRS1,LEP,LEPR,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,SREBF1,SREBF2,STAT3,STAT5B,TNF,cholesterol	
P3	 	NOTCH1	1.099	transcription regulator	 	-0.597	 	0.096	-1.094	4.95E-03	AKR1C1/AKR1C2,BCL2L1,CCND2,CCND3,CD14,CD68,CEBPB,CSF1R,CTGF,CTSG,CYR61,FCER1G,FCGR2A,FOS,FOSB,GAA,GRN,IGFBP3,IGFBP4,IRF8,LFNG,MCAM,NHLH1,PROX1,PTPRK,S100A1,SPP1,TGFB2,TIE1,TP63	AKT1,Akt,CTNNB1,EGFR,ERK1/2,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NOTCH1,NR4A1,RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	epigallocatechin-gallate	 	chemical drug	 	0.841	bias	-0.254	2.102	4.95E-03	APOB,APP,BCL2L1,BHLHE41,CEBPB,CLDN5,CTGF,CYR61,DAPK2,EGR1,FAS,FOS,FOSB,GJB2,HDAC2,HIF1A,HMOX1,ITGAV,JUNB,LEP,MKI67,MMP9,NFE2L2,PLAU,PRKCE,SFRP1,SLC16A1,TFRC,TOLLIP,VCAM1	CTNNB1,FOS,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,epigallocatechin-gallate	
P3	 	CREM	1.223	transcription regulator	 	-0.291	 	0.174	-0.929	5.03E-03	APOE,BTG2,CCND2,CEBPB,COL8A1,CSRNP1,DUSP1,DUSP4,EGR1,FOS,HMGCS1,HSPA4,IRAK1,JUNB,MKNK2,MSMO1,NAB2,NR4A1,SIAH2,SLC16A1,SPATA20,THBS1	CEBPA,CEBPB,CREB1,CREBBP,CREM,Creb,EP300,Ins1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RNA polymerase II,SREBF1,STAT3,TP53	
P3	 	PSEN2	1.462	peptidase	Inhibited	-2.255	 	-0.053	-2.051	5.05E-03	ABCC6,ACTB,APP,C1QA,C1QB,C3AR1,COX8A,CTSS,EMP1,GAPDH,GAS5,GNB1,KIF5B,STAB1,TNXB	JUN,MYC,NFKB1,PSEN1,PSEN2,TP53	
P3	 	CSF1R	2.452	kinase	 	0.555	bias	0.646	 	5.05E-03	CCND2,CSF1,CSF1R,FOS,JUNB,MSR1,VCAM1	Akt,CSF1,CSF1R,ELK1,ERK1/2,ETS2,FOS,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PTPN11,RELA,SP1,SPI1,STAT3,TP53	
P3	 	KEAP1	2.289	transcription regulator	 	-1.331	 	0.059	-1.485	5.05E-03	GSTP1,HMOX1,MMP9,NFE2L2,NQO1,PRDX1,VCAM1	15-deoxy-delta-12,14 -PGJ 2,BACH1,FOXO1,HIF1A,JUN,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA,STAT3,reactive oxygen species	
P3	 	arsenic	 	chemical toxicant	Activated	2.404	 	0.216	1.884	5.05E-03	FOS,FTH1,FTL,HIF1A,KEAP1,LTF,NQO1	BACH1,ELK1,FOS,JUN,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,PML,RELA,SP1,SRC,STAT3,arsenic,nitric oxide	
P3	 	methylselenic acid	 	chemical reagent	 	0.478	 	-0.206	0.971	5.05E-03	ACSL3,AKR1C1/AKR1C2,ALDH3A2,ATF5,BCL2L1,CDC42,CDK16,CDK2AP2,DDIT3,DUSP10,DYNLL1,EPHX1,ESR2,FKBP5,GDF15,H1F0,INPP4B,JUNB,KLF4,MAP1B,MAP2K3,MAPT,MATN2,MKI67,NQO1,PFDN5,PLCB4,SCD,TAF6,TOP2A,TUBB4B,UXS1,ZBTB16	ERK1/2,ESR1,ESR2,HIF1A,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,beta-estradiol,methylselenic acid	
P3	 	WNT3A	-5.359	cytokine	 	-1.589	bias	0.293	-3.167	5.11E-03	ADM2,ALPL,APP,ARRDC4,CALR,CCND2,CD68,CEBPB,CTGF,CXCL12,CYR61,EFNB1,ETV5,GSK3B,LRP6,MMP14,NCAM1,PDGFA,PLIN1,SDC4,SFRP2,SIM1,SLC7A1,SLC7A2,SOX9,TGFB2,THBS1,TMEM2,TNXB,TRIB3,VCAM1	Akt,CTNNB1,ERK1/2,FOXO3,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TCF7L2,TP53,Vegf,WNT3A	
P3	 	Laminin	 	complex	 	0.529	 	0.069	0.351	5.18E-03	APP,CDH11,ETV5,MAPT,MMP9,PLAU,RPSA,SDC4,TGFB2	APP,CTNNB1,ERBB2,HIF1A,Insulin,Laminin,MMP9,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,estrogen receptor	
P3	 	monocrotaline	 	chemical toxicant	 	0.218	 	0.108	-0.064	5.29E-03	CYBB,FHL1,HMOX1,HSP90AB1,NCAM1,PDGFA,SLC9A1,SPP1	 	
P3	 	MAP2K1/2	 	group	 	1.002	bias	0.486	-0.641	5.32E-03	CCND2,CHI3L1,CTGF,DDIT3,DUSP1,DUSP4,EGR1,FOS,HMOX1,HSPA5,MMP9,PDGFA	CEBPB,CTNNB1,ERK1/2,ESR1,FOS,FOXO1,FOXO3,Jnk,MAP2K1/2,MXI1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TP53	
P3	 	caffeine	 	chemical drug	 	-0.425	 	0.024	-0.499	5.32E-03	COX4I1,CTGF,EGR1,FOS,FOSB,HIF1A,HSD11B2,JUNB,MT-CO1,NR4A1,SREBF1,THBS1	Akt,CEBPA,CEBPB,CREBBP,IGF1,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,caffeine,cyclic AMP	
P3	 	lomustine	 	chemical drug	Activated	2.887	bias	0.599	 	5.32E-03	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,GSTM3,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	CLDN7	-1.319	other	 	-0.332	 	0.012	-0.382	5.37E-03	APLP2,APOE,ATP5G1,CA12,CD68,CTGF,DPM3,F5,FADS3,GRINA,LIMA1,MMP9,MRPL36,MRPS15,NNMT,PLGRKT,PRNP,RPL29,SLC25A22	 	
P3	 	metformin	 	chemical drug	Inhibited	-2.506	 	-0.241	-1.479	5.46E-03	ADIPOQ,APOB,ATF4,BIRC7,CCND2,CEBPB,DDIT3,DVL3,FOS,FTH1,HMOX1,HSPA5,IL1RN,LEP,MMP9,PCK1,PEA15,PKM,PLIN2,SREBF1,UCP2	CEBPA,CEBPB,CTNNB1,D-glucose,FOXO1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT3,TNF,metformin,rosiglitazone	
P3	 	24-hydroxycholesterol	 	chemical - endogenous mammalian	 	-0.438	 	0.142	-0.746	5.50E-03	APOE,APP,HSPA5,SREBF1,SREBF2	24-hydroxycholesterol,APOE,APP,CTNNB1,HIF1A,JUN,NFKB1,NFkB (complex),Pkc(s),RELA,SP1,STAT3,TP53	
P3	 	CBS/CBSL	1.334	enzyme	Inhibited	-2.236	 	-0.142	-1.919	5.50E-03	APOB,CLDN5,EEF1A1,GOT1,UNG	 	
P3	 	SPTLC2	-1.082	enzyme	 	-0.651	bias	-0.521	 	5.50E-03	ATF4,CTGF,DDIT3,HSPA5,THBS1	IL6,JUN,NFKB1,NFkB (complex),RELA,SPTLC2,STAT3	
P3	 	alpha-tocopherol succinate	 	chemical drug	 	-1.406	bias	-0.382	-0.570	5.50E-03	EGR1,FGF1,HIF1A,UCP2,VCAM1	CTNNB1,ERK1/2,FAS,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT3,alpha-tocopherol succinate,reactive oxygen species	
P3	 	fluoride	 	chemical - endogenous mammalian	 	1.969	bias	0.710	 	5.50E-03	DDIT3,FAS,FOS,HSPA5,VCAM1	ELK1,JUN,NFkB (complex),PRKCA,RELA,STAT3,fluoride	
P3	 	mir-214	1.770	microrna	 	0.334	bias	-0.581	 	5.50E-03	ALCAM,ATF4,LTF,PCK1,PSMD10	 	
P3	 	tauroursodeoxycholic acid	 	chemical - endogenous mammalian	 	 	 	 	 	5.50E-03	ADIPOQ,BCL2L1,CTGF,DDIT3,HSPA5	ADIPOQ,Akt,CREB1,ELK1,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PRKCA,PRKCE,RELA,SP1,STAT3,tauroursodeoxycholic acid	
P3	 	MAT1A	-5.523	enzyme	 	0.037	 	-0.169	0.438	5.57E-03	CYP4A11,EGR1,FAS,PHB,SAA1,SOD1	JUN,MAT1A,NFKB1,NFkB (complex),RELA,TP53,hydrogen peroxide	
P3	 	probucol	 	chemical drug	 	-1.342	 	-0.237	-0.812	5.57E-03	CTGF,CYBB,HMOX1,PSMA3,PSMA4,VCAM1	JUN,LDL,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,STAT3,probucol	
P3	 	2-bromoethylamine	 	chemical reagent	Activated	2.538	bias	0.623	 	5.70E-03	ANXA1,ANXA2,CAPN6,CD14,FCGR2A,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P3	 	PPARGC1B	1.626	transcription regulator	 	1.463	bias	0.552	 	5.70E-03	ATP5J2,COX4I1,COX5A,CYCS,EGLN3,ENO1,MINOS1,MVD,PCK1,SCD	CEBPB,ESRRA,FOXO1,PPARA,PPARGC1A,PPARGC1B,RELA,STAT3,palmitic acid	
P3	 	3,4,5,3',4'-pentachlorobiphenyl	 	chemical toxicant	 	1.674	bias	0.315	0.574	5.84E-03	CCND2,CES1,CLDN5,COMT,CYCS,CYP1B1,EPB41L3,GSTP1,HSPA2,IGFBP3,NQO1,NR2F1,PTGFR,TMSB10/TMSB4X	3,4,5,3',4'-pentachlorobiphenyl,CEBPB,FOS,JUN,NFkB (complex),NR3C1,PGR,RELA,SP1,TP53,progesterone	
P3	 	clofibrate	 	chemical drug	 	1.934	bias	0.359	0.532	5.93E-03	ABCC3,ACOT4,ANXA7,BSG,CCND2,CYP4A11,FAS,GSTP1,HADHB,HMOX1,IL1RN,NQO1,NR1H3,RTN4,SCD,UCP2	ACOX1,ATF6,Akt,CEBPA,JUN,NFE2L2,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,SREBF1,SREBF2,STAT3,cholesterol,clofibrate,oleic acid	
P3	 	GNRH1	-1.545	other	 	-1.163	bias	0.335	-2.237	5.97E-03	APP,DUSP4,EGR1,FOS,FOSB,FST,JUNB,PLAT,PRKCE,RPLP1,RPSA	CREB1,CREBBP,CTNNB1,Creb,ELK1,EP300,ERK1/2,FOS,GNRH1,Jnk,MAPK9,NFKB1,NFKBIA,NFkB (complex),PRKCE,RELA,RXRA,STAT3,TP53	
P3	 	calcitriol	 	chemical drug	 	-0.982	 	-0.045	-0.705	6.05E-03	ABCC3,ALDH1A2,ANLN,ANXA2,APP,BCL2L1,CCND3,CD14,CEBPB,CES1,CSE1L,CSF1,CSF1R,CYR61,DOK5,DUSP1,DUSP10,EGR1,ETV5,FAS,FECH,FOS,GAPDH,GEM,H2AFZ,HSPD1,IGFBP3,IL10RA,IL1RN,KLF4,LEP,LPAR1,LSM3,LTF,MAF,NCAM1,NUPR1,ODC1,PTGFR,RAB38,SERPINA1,SOCS3,SOD1,SPP1,SREBF1,STXBP6,SULF1,TGFB2,THBS1,THRA,TXN,UCP2,WSB1	CEBPA,CEBPB,ESR1,ESR2,HIF1A,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SMARCA4,SPI1,STAT3,TNF,beta-estradiol,calcitriol	
P3	 	MTORC1	 	complex	 	1.565	bias	0.507	 	6.12E-03	ATF4,KLF4,MBP,PKM,PLP1,SCD,SREBF1,SREBF2,UCHL1	AKT1,FOXO1,HIF1A,MTOR,MTORC1,NR3C1,NR4A1,PPARGC1A,RELA,SIRT1,SP1,SREBF1,SREBF2,STAT3,TP53	
P3	 	losartan potassium	 	chemical drug	 	-0.529	bias	-0.438	1.245	6.16E-03	ARAP1,ATF4,ATP5H,CTGF,CYBB,EGR1,FOS,HSPA5,ITGAV,MAPT,MMP9,PDGFA,SOCS3,SPP1,TGFB2,UCP2,VCAM1	AGT,ERK1/2,HIF1A,IL6,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,RELA,STAT3,losartan potassium	
P3	 	TAF4	1.266	transcription regulator	 	-0.943	bias	-0.461	0.264	6.25E-03	BCL2L1,CDH11,CTGF,GAS5,GJB2,IL1RN,KLF4,MAP4K4,OAS1,PDGFA,SCUBE1,SPP1,TAF10,TAF13,THBS1	 	
P3	 	NF1	1.097	other	 	-1.709	bias	-0.592	 	6.27E-03	BCL2L1,NPM1,PCK1,PDGFA,RPL21,RPS19,XIST	HRAS,JUN,NF1,NFKBIA,RELA,Ras,SP1,STAT3,TP53	
P3	 	THBS1	-4.660	other	 	0.479	 	0.055	0.337	6.27E-03	ADCYAP1R1,CTGF,EGR1,MMP9,PLAU,TGFB2,THBS1	CEBPB,ELK1,ERK,FOS,IFNG,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,Ras,SP1,STAT3,THBS1,TP53	
P3	 	butylated hydroxyanisol	 	chemical toxicant	 	1.345	bias	0.254	0.691	6.27E-03	FOS,GSTM3,GSTM4,GSTM5,GSTP1,NFE2L2,NQO1	BACH1,CTNNB1,FOS,JUN,Jnk,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA,STAT3,TP53,butylated hydroxyanisol,hydrogen peroxide	
P3	 	MAFF	-1.193	transcription regulator	Activated	2.000	bias	0.710	 	6.32E-03	ABCC3,GSTP1,NQO1,TXNRD1	 	
P3	 	MAPKAPK3	1.806	kinase	 	-0.849	 	-0.142	-0.567	6.32E-03	DDIT3,HSPA5,HSPB6,HSPB8	 	
P3	 	NCK1	1.128	kinase	 	-1.981	 	-0.079	-1.824	6.32E-03	ATF4,DDIT3,FOS,HSPA5	EIF2AK3,ERK1/2,FOXO3,NCK1,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53	
P3	 	RV 538	 	chemical reagent	 	-1.980	bias	-0.284	-1.418	6.32E-03	ATP13A2,BCL2L1,LAMP2,PRNP	 	
P3	 	Shc	 	group	 	1.214	bias	0.284	0.651	6.32E-03	BCL2L1,CCND2,CCND3,FOS	Akt,ERBB2,HRAS,JUN,NFE2L2,NFKBIA,NFkB (complex),PI3K (complex),RELA,Ras,SP1,STAT3,Shc,TP53,estrogen receptor	
P3	 	TAPI-1	 	chemical - protease inhibitor	 	-1.000	bias	-0.710	 	6.32E-03	APP,MMP9,MT-CO1,VCAM1	Akt,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TAPI-1	
P3	 	anacardic acid	 	chemical - endogenous non-mammalian	 	1.000	bias	-0.394	1.789	6.32E-03	DDIT3,HSPA5,MMP9,PLAT	CDKN1A,EP300,MYC,NFkB (complex),STAT3,TP53,anacardic acid	
P3	 	sphingomyelin	 	chemical - endogenous mammalian	Inhibited	-2.000	bias	-0.552	 	6.32E-03	NR1H3,PLTP,SCD,SREBF1	 	
P3	 	IDH1	1.212	enzyme	 	 	 	 	 	6.37E-03	ATF4,DDIT3,EDEM1,EGR1,LEP,MAPK10,SERPINH1,TGFB2	 	
P3	 	SUMO3	2.005	other	 	-0.478	 	-0.084	-0.258	6.37E-03	APP,CCND2,CXCL16,HLA-G,HMGA1,HSPA8,LY6E,MMP14	 	
P3	 	FGFR2	2.018	kinase	 	0.879	 	0.208	0.140	6.40E-03	AMOT,BMPER,CCND2,CDH11,CITED1,CLIC6,CUBN,DAB2,FAS,FGFR2,FST,HRAS,MBP,NR5A2,PLP1,SFRP1,SOX17,SPP1,VCAM1	Akt,CEBPA,ERK1/2,FGFR2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF	
P3	 	Pkc(s)	 	group	 	-0.954	bias	0.396	-2.637	6.41E-03	APP,BCL2L1,CCND3,CD4,CTGF,CTSB,CYBB,CYR61,DDIT3,DUSP1,EGR1,FAS,FOS,HIF1A,HMOX1,HOXA7,HSPA5,JUNB,LIPA,MMP9,MSR1,NQO1,NR1D1,NR4A1,S100A1,SPP1,STC2,VCAM1	CTNNB1,ERK1/2,FOS,HIF1A,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,STAT3,TP53	
P3	 	anisomycin	 	chemical - endogenous non-mammalian	Inhibited	-2.275	bias	0.271	-3.024	6.61E-03	BCL2L1,CYBB,DUSP1,EGR1,FOS,HSPA5,JUNB,NR4A1,PLAU,SPP1	CTNNB1,ELK1,ERK1/2,FOS,HIF1A,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,anisomycin	
P3	 	AMOT	-2.016	other	 	 	 	 	 	6.72E-03	CTGF,CYR61	 	
P3	 	APBA1	-1.119	transporter	 	 	 	 	 	6.72E-03	APP,LRP8	 	
P3	 	CYTH3	-1.074	other	 	 	 	 	 	6.72E-03	ARF1,ARF6	 	
P3	 	DST	-1.110	other	 	 	 	 	 	6.72E-03	DDIT3,HSPA5	 	
P3	 	EIF2A	1.274	translation regulator	 	 	 	 	 	6.72E-03	ATF5,PCK2	ATF4,DDIT3,EIF2A,STAT3	
P3	 	F5	-4.445	enzyme	 	 	 	 	 	6.72E-03	F5,MMRN1	 	
P3	 	FBXO25	1.166	enzyme	 	 	 	 	 	6.72E-03	EGR1,FOS	ELK1,FBXO25,FOS	
P3	 	GSTK1	1.249	enzyme	 	 	 	 	 	6.72E-03	ADIPOQ,DDIT3	 	
P3	 	IFI30	3.984	enzyme	 	 	 	 	 	6.72E-03	CTSS,HLA-A	 	
P3	 	IMPACT	1.543	other	 	 	 	 	 	6.72E-03	ATF4,DDIT3	 	
P3	 	KT 5926	 	chemical - kinase inhibitor	 	 	 	 	 	6.72E-03	CD14,VCAM1	 	
P3	 	LAMA1	-2.263	other	 	 	 	 	 	6.72E-03	MMP9,PLAU	ERK1/2,LAMA1,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3	
P3	 	LFM-A13	 	chemical - kinase inhibitor	 	 	 	 	 	6.72E-03	CCND2,HMOX1	Akt,CEBPB,CTNNB1,FOXO1,JUN,LFM-A13,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3	
P3	 	MRAP2	-1.936	other	 	 	 	 	 	6.72E-03	LEP,MRAP	 	
P3	 	NAGLU	2.530	enzyme	 	 	 	 	 	6.72E-03	LYZ,MAPT	 	
P3	 	NCEH1	1.269	enzyme	 	 	 	 	 	6.72E-03	DDIT3,HSPA5	 	
P3	 	NUBP1	1.537	other	 	 	 	 	 	6.72E-03	FTH1,TFRC	 	
P3	 	PLSCR3	-1.080	enzyme	 	 	 	 	 	6.72E-03	ADIPOQ,LEP	 	
P3	 	PTPRT	1.566	phosphatase	 	 	 	 	 	6.72E-03	BCL2L1,SOCS3	CEBPB,CTNNB1,FOXO1,NFKB1,PTPRT,RELA,STAT3	
P3	 	RACGAP1	1.149	transporter	 	 	 	 	 	6.72E-03	CD14,CDC42	 	
P3	 	TAT	-3.558	enzyme	 	 	 	 	 	6.72E-03	GLB1,MMP9	 	
P3	 	TXNDC5	1.472	enzyme	 	 	 	 	 	6.72E-03	CTSB,MMP9	 	
P3	 	cation	 	chemical - other	 	 	 	 	 	6.72E-03	GSTP1,ITGB2	 	
P3	 	dacetuzumab	 	biologic drug	 	 	 	 	 	6.72E-03	BCL2L1,TP63	 	
P3	 	dimethyl succinate	 	chemical - endogenous mammalian	 	 	 	 	 	6.72E-03	BSG,SLC16A1	 	
P3	 	hoechst 33342	 	chemical reagent	 	 	 	 	 	6.72E-03	FOS,SOX17	 	
P3	 	miR-483-5p (miRNAs w/seed AGACGGG)	 	mature microrna	 	 	 	 	 	6.72E-03	ALCAM,ARHGDIA	 	
P3	 	teleocidins	 	chemical toxicant	 	 	 	 	 	6.72E-03	FOS,ODC1	 	
P3	 	thiamine	 	chemical - endogenous mammalian	 	 	 	 	 	6.72E-03	AKR1B1,TKT	 	
P3	 	PLG	-4.177	peptidase	 	0.961	bias	0.690	 	6.73E-03	ADIPOQ,CSF1,CYR61,EDNRB,GULP1,MCOLN3,MMP9,PLAU,PRKCE,RAB7A,RALA,RAPGEF3,VDAC1	CEBPA,HIF1A,IGF1,IL1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PLG,RELA,SP1,STAT3,TGFB1	
P3	 	CD44	1.017	enzyme	 	1.021	bias	0.466	-0.743	6.99E-03	ACTB,BCL2L1,CALR,CCND2,CD63,CIDEA,COL5A2,DDIT3,FAS,FKBP4,FKBP5,HSP90AB1,IL1RN,ITGAV,KDM1B,MMP14,MMP9,PLAU,PTP4A3,SDC4,SERPINA1,SPP1,THBS1,VCAM1,WBP2	Akt,CD44,CEBPB,CSF2,IFNG,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	STAT4	1.234	transcription regulator	Activated	3.582	bias	0.710	 	7.04E-03	ALDOC,ATF4,BCL2L1,BSG,CCNI,COPG1,DAPK2,DPM3,ETV5,FCER1G,FSCN1,FYB,GAS5,GBE1,GCNT2,IL10RA,MAP3K1,P4HA2,PGP,PLOD2,R3HDM1,RASL12,RCN3,RRAGD,SH3GLB1,SOCS3,STC2,SYPL1,VDAC1	CEBPB,CTNNB1,FOXO1,IL4,IRF8,JUN,NFKB1,NFkB (complex),RELA,STAT3,STAT4	
P3	 	GLP-1-(7-34)-amide	 	chemical drug	 	-1.041	 	0.034	-1.121	7.13E-03	CEBPB,FOS,HMOX1,NQO1,NR4A1,VCAM1	Akt,CEBPB,CREB1,CREBBP,CREM,Creb,FOXO1,GCG,GLP-1-(7-34)-amide,Insulin,JUN,NFkB (complex),PPARA,PPARG,RELA,RNA polymerase II,SP1,SREBF1,STAT3,cyclic AMP	
P3	 	sucrose	 	chemical - endogenous mammalian	 	0.446	bias	0.382	-0.247	7.13E-03	APOE,APP,CRYM,FOS,FOSB,LEP	Akt,JUN,NFkB (complex),RELA,SP1,STAT3,sucrose	
P3	 	cyclic AMP	 	chemical - endogenous mammalian	 	0.040	bias	0.451	-2.444	7.19E-03	ADCYAP1,ADRA2A,APP,ASS1,CCND2,CDC42,CEBPB,CRYM,CTGF,CYCS,DDIT3,EGR1,FOS,GOT1,HIF1A,IGFBP3,IGFBP4,IL1RN,JUNB,LEP,MMP9,NR4A1,ODC1,PCK1,PFKFB1,PPP1R1B,PRNP,RAPGEF3,SOCS3,SOX9,SREBF1,THRSP,YWHAG	CEBPA,FOXO1,FOXO3,IL1B,INS,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,RELA,SP1,SREBF1,STAT3,TNF,TP53,cyclic AMP	
P3	 	glucocorticoid	 	chemical drug	 	0.041	 	0.068	-0.311	7.19E-03	ANXA1,BMP6,CCND3,CEBPB,CLDN5,CNR1,CSF1,CSF1R,CTGF,DUSP1,FAS,GLUL,GOT1,GRN,HMOX1,HRAS,IGFBP3,IL10RA,IL1RN,LEP,MMP9,ODC1,PCK1,PFKL,PLAT,PRNP,SOCS3,SPP1,TACR1,TGFB2,TNFRSF1A,VCAM1,ZBTB16	CEBPA,CEBPB,IFNG,IL4,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53,glucocorticoid	
P3	 	SNAI2	1.317	transcription regulator	Activated	2.041	 	0.149	1.614	7.19E-03	BSG,CDC42,CXCL12,DSP,ID4,MMP14,MMP9,SOX9,TP63	CTNNB1,MMP9,NFKB1,NFkB (complex),RELA,SNAI2	
P3	 	norepinephrine	 	chemical - endogenous mammalian	 	1.021	bias	0.412	-0.853	7.30E-03	APP,CEBPB,CHST2,CTGF,DES,DUSP1,EGR1,ELOVL1,FOS,FST,FTH1,GDF15,GEM,HMOX1,LEP,MAT2A,MCAM,MMP9,NPY1R,NR4A1,TFRC,THRSP,UBE2I	CEBPA,CTNNB1,FOS,IL1B,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53,norepinephrine	
P3	 	ACACB	-2.079	enzyme	Inhibited	-2.236	bias	-0.507	 	7.47E-03	LEP,MVD,SCD,SREBF1,SREBF2	ACACB,CEBPB,D-glucose,FOXO1,HIF1A,JUN,MYC,NFkB (complex),PPARA,PPARG,RELA,SREBF1,STAT3,fatty acid,palmitic acid	
P3	 	AQP1	-1.580	transporter	 	0.447	 	0.237	-0.082	7.47E-03	AKR1B1,CES1,HSPH1,MATN2,NUPR1	 	
P3	 	CFB	-1.040	peptidase	Activated	2.236	bias	0.621	 	7.47E-03	C3AR1,DDIT3,HSPA5,SREBF1,TGFB2	 	
P3	 	allyl sulfide	 	chemical drug	 	1.231	bias	0.266	0.641	7.47E-03	ABCC3,EPHX1,GSTM5,HMOX1,NFE2L2	 	
P3	 	hydrogen sulfide	 	chemical - endogenous mammalian	Activated	2.191	bias	0.426	1.257	7.47E-03	BCL2L1,DDIT3,HMOX1,HSPA5,TXN	BACH1,CEBPB,CTNNB1,FOXO1,Insulin,KEAP1,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,hydrogen sulfide	
P3	 	IFNA2	 	cytokine	 	1.994	bias	0.601	 	7.50E-03	ANXA1,ATF5,BAG3,CD28,CNP,DAD1,EGLN3,EPB41L3,FAS,FBXO8,GBP1,GEM,GOT1,HIF1A,HLA-A,HMGCS1,IFI27L2,LY6E,MMP9,MT-ATP6,MT1M,OAS1,PLAT,PSME1,RARRES3,SOCS3,THEMIS2,TNFRSF1A,USP18	ATF4,CEBPA,CEBPB,CTNNB1,EIF2AK2,FOXO1,IFNA2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,TP53	
P3	 	dimethyl sulfoxide	 	chemical drug	 	0.913	bias	0.421	-0.857	7.58E-03	ACTB,ADAM12,ANXA1,C1QTNF3,CALR,CCND2,CCND3,CEBPB,DDIT3,FECH,FOS,HMOX1,HSP90AB1,ITGB2,NUPR1,SMPD3,SQSTM1,TFRC,VCAM1	CEBPA,CTNNB1,ERK1/2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TCF7L2,TP53,dimethyl sulfoxide,sirolimus	
P3	 	PDLIM2	1.214	other	 	-0.258	 	-0.031	-0.139	7.66E-03	CLCN4,CRISPLD2,DNAJC15,GNG2,IGFBP3,KIT,MECOM,MYEOV,MYL9,NR2F1,PHLDA3,SCARA3,SRGAP1,STC2,TNS1	 	
P3	 	ERK	 	group	 	1.113	bias	0.440	-1.156	7.67E-03	ACTN1,BCL2L1,BMF,BTG2,BTG3,CCND3,CTGF,DUSP1,EGR1,FAS,FOS,FST,GDF15,GOT1,HMGA1,HMOX1,ITGB2,JUNB,MAP4K4,MCAM,MMP14,MMP9,NFE2L2,NFKBIZ,ODC1,PLAU,SLC4A7,THBS1,TYMP,UGCG	Akt,CEBPA,CEBPB,CTNNB1,ELK1,ERK,FOXO1,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT3,TNF,nitric oxide	
P3	 	AREG	-1.113	growth factor	 	1.118	bias	0.612	 	7.69E-03	BCL2L1,CDH11,EGR1,FOS,MMP9,PLAU,PTX3	AREG,CEBPB,CTNNB1,EGFR,ERBB2,ERK,ERK1/2,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TP53,estrogen receptor	
P3	 	bafilomycin A1	 	chemical drug	 	1.709	bias	0.269	1.003	7.69E-03	BCL2L1,CD151,CFTR,DDIT3,SLC7A1,SQSTM1,TRIB3	CEBPA,CTNNB1,FOS,JUN,Jnk,KRAS,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SNCA,STAT3,TNF,TP53,bafilomycin A1	
P3	 	caspase	 	group	 	0.728	bias	0.596	 	7.69E-03	APP,CCND2,CCND3,CD14,CDK6,GLUL,THBS1	AKT1,Akt,Creb,ELK1,ERBB2,FOXO1,IL2,JUN,Mek,NFKBIA,NFkB (complex),NR3C1,NR4A1,RELA,RNA polymerase II,SP1,STAT3,STAT5B,TP53,caspase,estrogen receptor	
P3	 	heparin	 	chemical - endogenous mammalian	 	-1.617	 	0.189	-2.176	7.74E-03	ALAS1,APOB,APOE,CD209,CD83,FOS,IGFBP3,MMP14,MMP9,MT-CO1,PLAT,TFPI	CEBPA,FN1,IL1B,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,VEGFA,heparin	
P3	 	CYR61	-4.141	other	 	0.668	bias	0.579	 	7.79E-03	BCL2L1,CCND2,CYR61,DVL1,HIF1A,ITGAV,NLK,NR4A1,PLAU,SFRP1,TIE1	CYR61,ERK1/2,FGF2,FOXO3,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TP53	
P3	 	F2R	1.075	g-protein coupled receptor	 	-1.609	bias	0.658	 	7.79E-03	CTGF,CXCL12,CYR61,DUSP1,EGR1,FOS,HMOX1,MMP9,NR4A1,THBS1,VCAM1	ELK1,ERK,F2R,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,TP53,nitric oxide	
P3	 	carbon monoxide	 	chemical - endogenous mammalian	 	1.679	bias	-0.254	2.497	7.79E-03	ATF4,CD14,CXCL12,DDIT3,EGR1,HIF1A,HMOX1,IRF8,LEP,NQO1,PRDX1	CEBPA,CEBPB,CTNNB1,FOS,FOXO1,IL1B,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,carbon monoxide	
P3	 	resiquimod	 	chemical drug	 	0.277	bias	0.441	-1.314	7.85E-03	AIF1,ATP6V1B2,CD83,CXCL12,FAS,FH,GDF15,GM2A,GNG2,IRAK1,KCNMA1,NFKBIZ,PARK7,PKM,PLAT,PLAU,PRDX1,PTX3,PYCARD,RAB7A,SPP1,WARS,YWHAB	CEBPB,CTNNB1,FOS,IFNG,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53,resiquimod	
P3	 	topotecan	 	chemical drug	 	-0.566	bias	-0.261	0.696	8.02E-03	ARPC1B,ASAP2,CD83,EFNB1,EGR1,ENO1,ERBB4,FAS,FOSB,GDF15,HIF1A,HNRNPK,HSPA8,HSPD1,JUNB,KCNMA1,MAT2A,NINJ1,PRNP,PTPRK,SESN2,SLC7A5,STK39,TOP2A,XPO6	MYC,NFKBIA,RELA,SP1,STAT3,TP53,topotecan	
P3	 	sphingosine-1-phosphate	 	chemical - endogenous mammalian	 	-1.521	bias	0.346	-2.767	8.08E-03	ANXA2,CTGF,EGR1,FAS,FOS,HDAC2,HIF1A,LEP,MMP14,MMP9,NFE2L2,PDGFA,THBS1,VCAM1	AKT1,Akt,CTNNB1,ERK,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR4A1,P38 MAPK,RELA,SP1,STAT3,TP53,sphingosine-1-phosphate	
P3	 	estrogen receptor	 	group	Inhibited	-2.877	 	-0.049	-2.634	8.14E-03	ADIPOQ,ANXA1,CAPG,CCND2,CD68,CDH11,COL6A1,CTGF,DSP,EGR1,ERBB4,FGF1,FGFR2,FLNC,FOS,HRAS,LTF,LY6E,MAP1B,MAPT,MMP14,MMP9,PCDH18,PCDH19,PCDH7,PDGFA,PLAU,POR,TGFB2,WNT5B	CEBPB,CREBBP,EGF,ELK1,ERK,ESR1,ESR2,FOS,HIF1A,JUN,NFkB (complex),RELA,SP1,STAT3,TP53,beta-estradiol,estrogen receptor	
P3	 	STAT3	-1.207	transcription regulator	 	1.127	bias	0.295	-0.747	8.16E-03	ADIPOQ,BCL2L1,BMF,CCDC88A,CCND2,CD209,CD83,CDON,CEBPB,CHI3L1,CLN6,CTGF,CTSB,CXCL12,DDIT3,DVL3,EGR1,ESR2,FAS,FCER1G,FOS,FSCN1,FST,HIF1A,HLA-A,HMOX1,HOXA10,IFI30,IL1RN,ITGAV,ITGB2,JUNB,KLF4,LEP,LTF,LYZ,MAF,MMP9,NFKBIZ,OAS1,PCK1,PEG10,PFKL,PHB,PLAU,PSMB5,RET,ROR1,SAA1,SERPINA1,SERPINE2,SLFN5,SOCS3,SREBF1,STC2,THBS1,USP18,WARS	CEBPA,CEBPB,CREBBP,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,TP53	
P3	 	baicalein	 	chemical - endogenous non-mammalian	 	-0.647	bias	-0.467	0.661	8.40E-03	BCL2L1,CCND3,CYBB,DDIT3,FOS,HMOX1,MMP9,MT-CO1,VCAM1	Akt,CTNNB1,FOS,JUN,Jnk,MMP9,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT3,baicalein	
P3	 	miR-483-3p (miRNAs w/seed CACUCCU)	 	mature microrna	Inhibited	-2.358	bias	-0.710	 	8.40E-03	CREBL2,ERP29,HNRNPA0,MAPKAPK2,MKI67,PGAM1,RAN,SLC7A1,SOCS3	 	
P3	 	SATB1	-1.350	transcription regulator	 	0.301	 	-0.137	0.930	8.44E-03	ACTG1,ACTN1,CTNNA1,CTSD,CYBB,DUSP4,EPSTI1,F5,FAM129A,FOSB,GDF15,HSPA8,IL10RA,IRF8,KLF2,LPIN2,NFE2L2,P2RY8,PSMD2,RPLP0,RPLP1,TMEM2,WARS	 	
P3	 	mir-210	 	microrna	Inhibited	-2.866	bias	-0.648	 	8.46E-03	ABCC3,CTGF,CXCL12,FAM102A,GDE1,KCMF1,KIAA0930,LASP1,MRPL36,NCAM1,NDUFA4,PSAP,SCARA3,TNPO1,UBQLN1	 	
P3	 	2,3,4,7,8-pentachlorodibenzofuran	 	chemical toxicant	 	0.818	 	0.137	0.392	8.77E-03	CES1,COMT,CYCS,CYP1B1,EPB41L3,HSPA2,NQO1,NR2F1,PTGFR,TMSB10/TMSB4X	2,3,4,7,8-pentachlorodibenzofuran,CEBPB,NFkB (complex),NR3C1,PGR,RELA,progesterone	
P3	 	NKX3-1	-2.374	transcription regulator	 	 	 	 	 	8.77E-03	BTG2,CA12,CTSB,FOS,IGFBP3,MMP9,PTP4A2,PTPRC,PTPRK,SDC4	ELK1,ERK1/2,FOS,FOXO1,FOXO3,HIF1A,MAP2K1/2,NFKB1,NFKBIA,NFkB (complex),NKX3-1,PI3K (family),RELA,SP1,STAT3,TP53	
P3	 	miR-145-5p (and other miRNAs w/seed UCCAGUU)	 	mature microrna	 	-1.835	bias	-0.710	 	8.77E-03	CES1,DTD1,FBXO28,FSCN1,KLF4,LAMP2,NDUFA4,SPTB,TPM3,UNG	 	
P3	 	mir-15	 	microrna	Inhibited	-2.939	bias	-0.541	 	8.77E-03	APP,CARM1,CCND2,CDC42,CDK6,EIF4G2,FGF1,HMGA1,MMP9,UCP2	 	
P3	 	MMP9	5.807	peptidase	 	0.503	 	0.067	0.296	8.85E-03	BCL2L1,CLDN5,CTSB,CXCL12,DDIT3,FOS,MMP14,MMP9,SDC4,SERPINA1,SERPINE2	CEBPA,CTNNB1,IL1B,JUN,MMP9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TCF7L2,TNF,TP53	
P3	 	Y 27632	 	chemical drug	 	0.166	bias	-0.297	1.089	8.85E-03	ACTB,ACTG1,CEBPB,CLDN5,CTGF,FOS,MMP9,PLAU,SOX9,THBS1,VCAM1	EDN1,ELK1,ERK1/2,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT3,TP53,Y 27632	
P3	 	miR-1-3p (and other miRNAs w/seed GGAAUGU)	 	mature microrna	Inhibited	-4.726	bias	-0.710	 	8.87E-03	ANXA2,AP3D1,ATP6V1B2,C12orf49,CERS2,CHST11,CLCN3,EML4,HACD3,KLHL42,LASP1,POLR2K,PPIB,RAB11FIP2,SDC4,SH3BGRL3,SLC25A1,SLC25A22,THBS1,TMSB10/TMSB4X,TPM3,TRIM2,TWF1,UHMK1,UST,XPO6	 	
P3	 	ADIPOQ	-2.144	other	 	-0.871	 	0.098	-1.235	8.88E-03	ACSM5,ADIPOQ,CTGF,CYBB,DUSP1,EGR1,ESR2,FOS,HMOX1,LEP,MSR1,NR1H3,PCK1,PFKFB1,PRDX5,SCD,SHC1,SREBF1,UCP2,VCAM1	ADIPOQ,ATF6,CEBPB,FOXO1,Insulin,LDL,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT3,STAT5B,oleic acid,palmitic acid	
P3	 	reactive oxygen species	 	chemical toxicant	Activated	2.109	bias	0.594	 	8.94E-03	ABCC1,ADAM17,ADAM9,ADIPOQ,BCL2L1,CSF1R,CTGF,DDIT3,FAS,HIF1A,HMOX1,HSPA5,LEP,NFE2L2,PHB,PRDX5,UCP2,VCAM1	Akt,CEBPA,CTNNB1,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT3,TNF,reactive oxygen species	
P3	 	mycophenolic acid	 	chemical drug	 	-0.535	bias	0.453	-2.231	8.96E-03	CCND2,CCND3,CD63,CDK6,CTGF,CYBB,CYR61,DUSP1,GBP1,GNL3,HSPA5,MYL12A,SLC30A1,UGCG	EDN1,ELK1,FOS,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,SREBF1,STAT3,TP53,mycophenolic acid	
P3	 	9Z,11E-octadecadienoic acid	 	chemical - endogenous non-mammalian	 	-0.294	 	-0.031	-0.220	9.00E-03	CYP4A11,IL10RA,SORBS1,SREBF1,THBS1,UCP2	9Z,11E-octadecadienoic acid,CEBPA,FOXO1,JUN,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,fatty acid	
P3	 	CASP8	-1.022	peptidase	 	-0.512	 	0.194	-0.942	9.00E-03	ADAM17,CD14,FAS,FOS,HDAC2,MMP9	CASP8,CEBPB,CREBBP,CTNNB1,ELK1,ESR1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT3,TCF7L2,TP53	
P3	 	NAMPT	1.180	cytokine	 	1.671	bias	0.463	0.553	9.00E-03	ATXN10,MMP9,NPY1R,PEG10,TFPI,TGFB2	FOXO1,NAMPT,PPARG,PPARGC1A,SIRT1,SREBF1,STAT3	
P3	 	miR-30a-3p (and other miRNAs w/seed UUUCAGU)	 	mature microrna	 	0.000	bias	-0.710	 	9.00E-03	CDK6,CYR61,HDAC2,LIMA1,THBS1,TMEM2	 	
P3	 	pregna-4,17-diene-3,16-dione	 	chemical - endogenous non-mammalian	 	0.182	bias	-0.587	 	9.00E-03	ABCB11,ADIPOQ,BCL2L1,CES1,MMP9,SREBF1	NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TP53,pregna-4,17-diene-3,16-dione	
P3	 	SUMO2	1.348	enzyme	 	-0.478	 	-0.108	-0.195	9.03E-03	ABCB11,CCND2,CXCL16,HLA-G,HMGA1,HSPA8,LY6E,MMP14	APP,CEBPB,CREBBP,ELK1,ESR1,HIF1A,NFKB1,NFkB (complex),RELA,SP1,SUMO2,TP53	
P3	 	ibuprofen	 	chemical drug	 	-0.803	 	-0.222	-0.234	9.03E-03	APP,CYBB,EDNRB,GDF15,HIF1A,MMP9,PLIN2,PTPRC	APP,CEBPA,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT3,TP53,ibuprofen	
P3	 	6-cyano-7-nitroquinoxaline-2,3-dione	 	chemical reagent	 	 	 	 	 	9.10E-03	EGR1,FOS,JUNB	6-cyano-7-nitroquinoxaline-2,3-dione,CTNNB1,PRL,SP1,STAT3,STAT5B,TP53	
P3	 	ATP2B2	-3.784	transporter	 	 	 	 	 	9.10E-03	CALR,DDIT3,HSPA5	ATP2B2,EIF2AK3,FOXO3,TP53	
P3	 	CD99	1.420	other	 	 	 	 	 	9.10E-03	FOSB,MMP9,PTPRC	CD99,HIF1A,NFKB1,NFkB (complex),SP1,STAT3,TGFB1	
P3	 	CNGB3	-2.683	ion channel	 	 	 	 	 	9.10E-03	CAPN2,DDIT3,HSPA5	 	
P3	 	DOHH	-1.140	enzyme	 	 	 	 	 	9.10E-03	NME1,PARK7,WARS2	 	
P3	 	EN2	-2.496	transcription regulator	 	 	 	 	 	9.10E-03	ALDOC,PAX5,PLCB4	 	
P3	 	F Actin	 	complex	 	 	 	 	 	9.10E-03	CTGF,CTSS,FLNA	 	
P3	 	Irs3	 	other	 	 	 	 	 	9.10E-03	EGR1,LEP,SREBF1	AKT1,CREB1,CTNNB1,ELK1,FOXO1,FOXO3,HMGA1,INSR,IRS1,Irs3,NFE2L2,NFkB (complex),NR4A1,PDX1,PI3K (complex),RELA,SP1,STAT3,STAT5B,TP53	
P3	 	KRT19	1.192	other	 	 	 	 	 	9.10E-03	EIF2S1,ERP29,HSPA5	 	
P3	 	MALSU1	2.405	other	 	 	 	 	 	9.10E-03	COX4I1,MT-CO1,MT-ND1	 	
P3	 	PLA2G6	-1.415	enzyme	 	 	 	 	 	9.10E-03	ATF4,BCL2L1,DDIT3	Akt,CTNNB1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PLA2G6,RELA,SP1,STAT3	
P3	 	SDC4	3.011	other	 	 	 	 	 	9.10E-03	KLF2,KLF4,SOX9	 	
P3	 	SLC6A2	-2.337	transporter	 	 	 	 	 	9.10E-03	ADCY1,DYNLL1,PSAP	CREB1,CREBBP,Creb,ELK1,FOXO1,SLC6A2,cocaine	
P3	 	STC1	-1.517	kinase	 	 	 	 	 	9.10E-03	TGFB2,UCP2,XIST	 	
P3	 	UDP-D-glucose	 	chemical - endogenous mammalian	 	 	 	 	 	9.10E-03	CALR,HSPA5,HYOU1	 	
P3	 	ZMYND10	-2.293	other	 	 	 	 	 	9.10E-03	MMP14,MMP9,THBS1	FOS,JUN,NFkB (complex),RELA,SP1,TP53,ZMYND10	
P3	 	4-hydroxyestradiol-17beta	 	chemical - endogenous mammalian	 	1.964	bias	0.568	 	9.29E-03	HSPA5,LTF,NQO1,SFRP2	 	
P3	 	AFP	-1.419	transporter	 	 	 	 	 	9.29E-03	EGR1,FOS,MMP9,TNFRSF12A	17-alpha-ethinylestradiol,AFP,CEBPA,ESR1,NFkB (complex),SP1	
P3	 	CNB-001	 	chemical reagent	Activated	2.000	bias	0.581	 	9.29E-03	ASNS,ATF4,DDIT3,SLC7A11	 	
P3	 	EPHB1	-2.146	kinase	 	-1.987	bias	0.581	 	9.29E-03	EGR1,FOS,JUNB,PCK1	EPHB1,ERK,ERK1/2,HRAS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RAF1,RELA,SP1,STAT3,TP53	
P3	 	Integrin	 	complex	 	0.392	bias	0.710	 	9.29E-03	FOS,MMP14,MMP9,SOCS3	Akt,CTNNB1,FN1,FOS,Integrin,JUN,Jnk,MMP9,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT3	
P3	 	OSBPL8	1.225	transporter	 	1.000	 	0.142	0.716	9.29E-03	APOE,NR1H3,SREBF1,SREBF2	 	
P3	 	TAS1R3	-1.438	g-protein coupled receptor	Inhibited	-2.000	bias	-0.323	-1.354	9.29E-03	SLC16A1,SLC1A5,SLC3A2,SLC7A11	 	
P3	 	coal tar	 	chemical drug	Activated	2.000	bias	0.581	 	9.29E-03	CYP1B1,GSTP1,HMOX1,NQO1	AHR,ESR1,NFkB (complex),RELA,SP1,TP53,coal tar	
P3	 	enoxacin	 	chemical drug	 	-1.000	bias	-0.581	 	9.29E-03	ATP6V1B2,ATP6V1E1,FOS,LCP1	 	
P3	 	enterolactone	 	chemical - endogenous non-mammalian	 	1.000	bias	0.581	 	9.29E-03	ESR2,IL1RN,MKI67,SPP1	 	
P3	 	latrunculin B	 	chemical reagent	 	 	 	 	 	9.29E-03	ACTB,CTGF,FOS,MYOC	Akt,EDN1,ELK1,ERK,ERK1/2,JUN,MKL1,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,latrunculin B	
P3	 	salubrinal	 	chemical reagent	 	-0.063	bias	-0.323	0.571	9.29E-03	ATF4,EIF2S1,HSPA5,SQSTM1	 	
P3	 	Nuclear factor 1	 	group	 	 	 	 	 	9.34E-03	ALAS1,ALDOA,CHI3L1,DDIT3,GSS,HSD11B2,SLC25A5	 	
P3	 	eplerenone	 	chemical drug	 	-1.968	bias	-0.521	 	9.34E-03	ADIPOQ,CD68,CTGF,CYBB,PDGFA,SPP1,VCAM1	CEBPA,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT3,TNF,eplerenone	
P3	 	proteasome inhibitor PSI	 	chemical - protease inhibitor	 	1.947	 	0.237	1.348	9.34E-03	DDIT3,FAS,HMOX1,HSPA5,NFE2L2,PRKCE,SQSTM1	CEBPA,ERK,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT3,TNF,TP53,proteasome inhibitor PSI	
P3	 	ERG	-1.585	transcription regulator	 	1.807	bias	0.589	 	9.46E-03	ACTN1,APOC1,ARHGEF2,CHTOP,CLIP1,CNR1,COLGALT1,EPB41L3,FHL1,FKBP5,FLNC,FOSB,GMFB,MMP9,MYO1D,MYO5A,PLAT,PLAU,PLEK,RAB7A,RPS11,SPP1,SREBF2,THBS1,TRIOBP,ZBTB16	ERG,ETS1,FOS,JUN,NFE2L2,NFKB1,NFkB (complex),RELA,SP1,SRC,TP53	
P3	 	salmonella minnesota R595 lipopolysaccharides	 	chemical - endogenous non-mammalian	 	1.251	bias	0.710	 	9.72E-03	ADAM9,ATP6V1E1,CD83,EDNRB,EGR1,FOS,FOSB,GDF15,IRF8,JUNB,LPAR1,MKI67,NFKBIZ,SLC7A2,SLFN5,SOCS3,TPM3,VCAM1	CEBPA,CTNNB1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3,TNF,salmonella minnesota R595 lipopolysaccharides	
P3	 	PRKACA	2.127	kinase	 	0.333	bias	0.502	 	9.76E-03	ADIPOQ,ALAS1,CCND2,CCND3,CEBPB,LEP,PCK1,SOCS3,VCAM1	Akt,CEBPA,CEBPB,CREBBP,ERK1/2,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,PRKACA,RELA,RNA polymerase II,SP1,STAT3,TNF,cyclic AMP	
P3	 	KCNE3	1.848	ion channel	 	 	 	 	 	9.78E-03	AKR1C3,BCAT1,CSRNP1,DUSP6,FOSB,KLF4,NR4A1,OSGIN1,PLP1,PTPRQ,SLC2A5,VSIG4	 	
P3	 	ACSL5	-1.009	enzyme	 	-0.447	 	0.042	-0.541	9.87E-03	ANOS1,GALNT13,MCAM,PEG10,PHLDA2	 	
P3	 	BTG2	-5.838	transcription regulator	 	 	 	 	 	9.87E-03	BTG2,HMOX1,NCAM1,NQO1,SOD1	BACH1,BTG2,KEAP1,NFE2L2,NFKB1,NFkB (complex),RELA	
P3	 	NCAM1	-2.096	other	 	0.277	bias	0.543	 	9.87E-03	CALR,GLUL,HSPA4,NCAM1,THBS1	 	
P3	 	glutamyl-Se-methylselenocysteine	 	chemical - endogenous mammalian	 	-0.447	bias	-0.459	0.580	9.87E-03	EGR1,GSTP1,PSME1,RPS11,SOD1	 	
P3	 	GDF2	 	growth factor	Activated	2.240	bias	0.642	 	9.92E-03	CDH11,CXCL12,ELOVL1,FOS,HIF1A,HSPB8,MMP9,NINJ1,PROX1,SEMA3B,SERPINE2,SLC3A2,SLC6A6,SPP1	CTNNB1,ERK1/2,GDF2,MMP9,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,STAT3	
P3	 	amphetamine	 	chemical drug	 	-1.006	bias	0.391	-2.004	9.92E-03	ATF4,BCL2L1,CSF1R,EGR1,EIF4G2,FOS,FOSB,GNB1,HN1,HSPA4,HSPA8,JUNB,STIP1,UCHL1	AKT1,CREB1,CREBBP,CREM,Creb,DRD1,ERK1/2,ETS1,FOS,FOXO1,HTT,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR4A1,RELA,RNA polymerase II,SP1,STAT3,TP53,amphetamine,estrogen receptor	
P3	 	ATM	1.060	kinase	 	-1.698	bias	0.537	 	1.00E-02	ACTB,ADIPOQ,CTGF,DUSP1,DUSP10,FAS,HMOX1,HSP90AB1,HSPE1,LEP,PSMC4	 	
P3	 	EOMES	1.229	transcription regulator	 	-1.993	 	0.027	-2.079	1.00E-02	ADCYAP1,AFAP1,CRYM,DNAJC15,DUSP4,FAT3,NHLH1,NXPH4,SV2B,TMEM2	 	
P3	 	FGF10	1.463	growth factor	Activated	2.959	bias	0.680	 	1.00E-02	ANXA1,ANXA2,CEBPB,CTSB,CYP1B1,LFNG,MMP14,SCD,SOX9,TMEM123	 	
P3	 	chromium	 	chemical drug	Inhibited	-3.162	bias	-0.549	 	1.00E-02	ABHD4,ARHGDIA,CDK2AP2,DOK5,ENTPD5,NQO1,PGD,PPIF,SLC1A4,TAF6	 	
P3	 	SPP1	5.959	cytokine	Activated	4.113	bias	0.453	2.089	1.01E-02	ADIPOQ,BCL2L1,CAPNS1,COX7A2L,CXCL12,DSP,FGFR2,FOS,HMOX1,HTATIP2,ITGAV,MECR,MMP14,MMP9,NDUFB9,NDUFS4,NDUFS8,PDGFA,PGD,PLAU,POR,SOX9,SPP1,VAT1	 	
P3	 	SOX3	-5.548	transcription regulator	 	-0.577	bias	-0.672	 	1.05E-02	BMPER,CITED1,DSP,DUSP1,DUSP4,PCDH18,RET,SOX17,SOX9,TGFB2,TXNRD1,USP18,ZBTB16	 	
P3	 	VCAN	1.501	other	 	-0.722	 	-0.087	-0.343	1.05E-02	APOE,ASS1,CBX6,CEBPB,CIDEA,CRISPLD2,CXCL12,FAS,FNDC1,FST,GLB1,IGFBP4,IL1RN,MAP1B,OLFML2B,PRDX5,PRELP,SPATS2L,VCAM1	 	
P3	 	KLF3	-1.111	transcription regulator	Inhibited	-2.474	 	-0.212	-1.169	1.05E-02	ANXA5,APOE,APRT,ARPC4,ATF4,BCAP29,C11orf24,CAMK2D,CAPG,CAPNS1,CCT3,CEP170B,CHCHD10,CTNNA1,DEGS1,EIF5A,EPRS,FAM49A,FOS,GSTP1,HLCS,HPS1,KLF8,MRPL14,MTCH2,MYO5A,NDUFV3,NSMAF,PRKACA,PSMD7,PTP4A2,RAB7A,RAD51C,RUVBL1,SERPINH1,SPTB,TPM3,TYROBP,UGCG,WSB1	 	
P3	 	Sb202190	 	chemical - kinase inhibitor	 	0.141	bias	-0.481	2.142	1.06E-02	ATP5J2,CCND2,CCND3,CEBPB,CFTR,CTGF,EGR1,FGFR2,FOS,HIF1A,HMOX1,HSPA5,JUNB,MMP9,P4HA1,PRDX1,TP63,TYMP	 	
P3	 	CP-55940	 	chemical reagent	 	 	 	 	 	1.06E-02	ACTB,ALDOC,BCL2L1,BTG2,CSF1,GAPDH,JUNB,RPL13A	 	
P3	 	memantine	 	chemical drug	 	0.083	bias	0.441	-1.143	1.06E-02	BCL2L1,CLDN5,FOS,GSTP1,HSP90AB1,HSPA5,POR,SIRPA	 	
P3	 	nitrofen	 	chemical toxicant	Inhibited	-2.121	bias	-0.710	 	1.06E-02	CLCN7,EGR1,ENO1,FGFR2,HK1,HYOU1,PLD3,RTN4	 	
P3	 	panobinostat	 	chemical drug	Inhibited	-2.804	bias	-0.264	-2.064	1.06E-02	BCL2L1,CCND2,CDC42,CDK6,FLNA,KIT,PSMD10,TP63	 	
P3	 	TGM2	1.634	enzyme	 	1.755	bias	0.305	0.148	1.07E-02	ALPL,BTG2,CD300C,CDK6,CSRNP1,DAPK2,FARSB,FCER1G,GM2A,HIF1A,IL10RA,LGALS9,LY6E,MMP9,OAS1,PLEKHO2,POR,PPP1R16B,RARRES3,SDCBP,SIRPA,SLC16A1,SLC20A1,SLC7A2,SLFN5,SPP1,THBS1,TYROBP,VSIG4	 	
P3	 	ID3	1.110	transcription regulator	 	0.635	 	-0.114	1.080	1.08E-02	ADIPOQ,BCL2L1,CCND2,CD83,CEBPB,CSF1,DUSP1,DUSP10,DUSP4,FCER1G,G6PC3,GNL3,HIF1A,IL10RA,IL20RB,IRF8,LMO4,MAF,MMP9,NR4A1,SOCS3,TNFRSF1A,TRAF3,ZBTB16	 	
P3	 	gefitinib	 	chemical drug	 	 	 	 	 	1.09E-02	ADAMTS15,BCL2L1,BMF,BTG2,CEBPB,COL15A1,COL8A1,CTSA,CTSB,EPSTI1,FGFR2,HMOX1,HYAL1,ID4,KIT,LTF,MAP4K4,MKI67,SP2,TOP2A,WNT5B	 	
P3	 	N-nitro-L-arginine methyl ester	 	chemical drug	 	0.560	 	0.045	0.401	1.10E-02	ADIPOQ,BCL2L1,CD68,CD83,CSF1,CTGF,CYBB,FAS,HMOX1,ITGAV,MAP1B,MMP9,SOD1,VCAM1	 	
P3	 	GNRH	 	group	 	-0.966	bias	0.426	-1.889	1.12E-02	ADCYAP1,ADIPOQ,DUSP1,EGR1,FOS,PHB	 	
P3	 	TIMP1	1.778	cytokine	 	1.134	 	0.095	0.883	1.12E-02	BCL2L1,CTSG,IGFBP3,MMP9,PLAT,PLAU,PLTP	 	
P3	 	fluvoxamine	 	chemical drug	 	 	 	 	 	1.12E-02	ACTB,ADIPOQ,FOS,GAPDH,GLB1,RACK1,RPL13A	 	
P3	 	grape seed extract	 	chemical drug	 	 	 	 	 	1.12E-02	APP,CDK6,ENO1,HSPA8,HSPD1,MKI67,PLAU	 	
P3	 	prostaglandin J2	 	chemical - endogenous non-mammalian	Activated	2.621	bias	0.521	 	1.12E-02	GDF15,HMOX1,PSMA3,PSMA5,PSMB7,PSMD3,PSMD8	 	
P3	 	semaxinib	 	chemical drug	 	-1.982	 	-0.237	-1.513	1.12E-02	FHL1,HIF1A,HMOX1,LTF,MMP9,NFE2L2,THBS1	 	
P3	 	bezafibrate	 	chemical drug	 	0.056	bias	0.496	-1.787	1.13E-02	ABCB11,ACAD11,ACOT4,ADIPOQ,ALDH1A2,APOE,COX4I1,HADHB,HSPA5,LEP,MT-CO1,NR1H3,SCD,TSPO,UCP2	 	
P3	 	VitaminD3-VDR-RXR	 	complex	 	0.523	bias	0.463	-0.850	1.13E-02	CD14,HOXA10,IGFBP3,IGFBP6,KLF4,PDGFA,SEMA3B,SPP1,TGFB2	 	
P3	 	5-N-ethylcarboxamido adenosine	 	chemical reagent	 	0.055	 	-0.034	0.187	1.14E-02	BAG3,BTG2,CES1,CTGF,DAD1,EGR1,HIF1A,HMOX1,JUNB,MNAT1,NR4A1,ODC1,SLC4A7,SOCS3,SOX17,THBS1	 	
P3	 	pyrrolidine dithiocarbamate	 	chemical reagent	 	-0.790	bias	-0.497	1.154	1.14E-02	ANXA1,ASS1,BCL2L1,BMF,CFTR,CTGF,GCLM,HIF1A,HMOX1,MAFG,MMP14,MMP9,NR4A1,RACK1,SOX9,VCAM1	 	
P3	 	HDAC5	1.057	transcription regulator	 	1.964	 	-0.089	2.138	1.14E-02	ATP5D,COX7A1,KLF2,LMOD2,NDUFA1,NR4A1,PFKL,RAD23B,SCD,TNFRSF1A	 	
P3	 	MAP3K1	1.806	kinase	 	0.853	bias	0.511	 	1.14E-02	CSTA,DUSP1,EGR1,FAS,FOS,HMOX1,PLAU,PRDX1,THBS1,TOP2A	 	
P3	 	cardiotoxin	 	chemical - other	Activated	2.530	bias	0.710	 	1.18E-02	APRT,ATP6V1A,CAPN6,CCND2,CCND3,CSF1R,EDNRB,GM2A,HSPA5,IL10RA,IL1RN,ITGB2,NPM1,PGAM1,PTPRC,RPSA,SFRP2,SNRPD1,SPP1,TXNRD1,UCP2	 	
P3	 	SRF	1.095	transcription regulator	 	-1.869	bias	0.304	-3.120	1.22E-02	ACTB,BCL2L1,CENPB,CLDN5,CMA1,CPA3,CPM,CTGF,CTSG,DES,EGR1,EIF6,FGF1,FHL1,FLNA,FOS,FOSB,FST,G0S2,GSTM5,JUNB,LDB3,LMCD1,LPCAT3,LTF,MAP4K4,MAPK10,MMP9,MYH1,MYL9,NPM1,NR4A1,OSCP1,PKHD1L1,PPIA,RNH1,SREBF2,TCF7,TUBB4B	 	
P3	 	olanzapine	 	chemical drug	 	-0.208	 	0.212	-0.992	1.23E-02	AOX1,FGFR2,FOS,GSK3B,HDAC2,HLA-G,HMGCS1,HMOX1,HSPA8,NR4A1,PPP2R1A,SLC24A3,SLC38A1,SNCG,SOD1	 	
P3	 	mir-223	 	microrna	 	-0.114	 	0.176	-0.856	1.24E-02	ALCAM,CARM1,CSF1,CTSG,EMP1,GFPT1,GPR65,GSTM5,HMGCS1,HPGDS,IL1RN,MMP25,MSMO1,MYO1D,NQO1,RAB38,SGPL1,SLC39A1	 	
P3	 	HDL	 	complex	 	0.859	 	-0.127	1.213	1.24E-02	ADIPOQ,EGLN3,HIF1A,ITGAV,ITGB2,SIAH2,SREBF1,VCAM1	 	
P3	 	alvocidib	 	chemical drug	 	-1.341	bias	-0.561	 	1.24E-02	AIF1,BCL2L1,CCND3,FOS,RHOBTB2,TCEA1,TXN,XRCC6	 	
P3	 	phenethyl isothiocyanate	 	chemical drug	 	 	 	 	 	1.25E-02	BCL2L1,BPIFB2,CAPN2,CCT4,GCLM,GSS,H2AFZ,MAP2K3,NNMT,QSOX1,RAB1A,RABIF,TTC1,TXN,TXNL1,TXNRD1	 	
P3	 	ARHGDIG	-1.392	other	Inhibited	-2.236	bias	-0.710	 	1.28E-02	ALCAM,ANXA1,COL5A2,DUSP6,LPAR1	 	
P3	 	AXIN1	1.523	other	 	-0.849	bias	-0.444	0.030	1.28E-02	CCND2,CSRNP1,FOS,GSK3B,HRAS	 	
P3	 	BID	1.132	other	Activated	2.219	bias	0.631	 	1.28E-02	ADAM17,C3AR1,CTSB,CTSD,CTSS	 	
P3	 	FDFT1	1.061	enzyme	 	0.447	 	0.237	-0.082	1.28E-02	APOB,CYP27A1,NR1H3,SREBF1,SREBF2	 	
P3	 	LYL1	-1.406	transcription regulator	 	 	 	 	 	1.28E-02	BCL2L1,BTG2,CCND3,EGR1,ID4	 	
P3	 	MPZ	1.477	other	 	 	 	 	 	1.28E-02	ATF4,DDIT3,HMGCS1,HSPA5,MVD	 	
P3	 	NAB2	2.985	transcription regulator	 	-0.849	bias	-0.615	 	1.28E-02	ALOX5AP,FOS,ID4,NAB2,PLAU	 	
P3	 	Pdgf Ab	 	complex	 	0.506	bias	0.543	 	1.28E-02	COL8A1,FOS,HIF1A,HMOX1,SCD	 	
P3	 	RARRES2	1.202	transmembrane receptor	 	-1.342	 	0.079	-1.518	1.28E-02	ADIPOQ,CCND2,LEP,PHB,PLIN1	 	
P3	 	SLC6A3	-7.099	transporter	 	1.067	 	0.142	0.786	1.28E-02	ADCY1,DYNLL1,FOSB,PPP1R1B,PSAP	 	
P3	 	Zn2+	 	chemical - endogenous mammalian	 	-0.447	 	0.237	-0.976	1.28E-02	APP,FOS,MMP9,SLC30A1,SLC39A6	 	
P3	 	cuprizone	 	chemical toxicant	 	-0.298	bias	0.394	-1.169	1.28E-02	CSPG4,FOS,MBP,PLP1,SOCS3	 	
P3	 	dichlororibofuranosylbenzimidazole	 	chemical toxicant	 	-1.980	bias	-0.444	-1.101	1.28E-02	CTSD,ESR2,HIF1A,MMP9,SREBF1	 	
P3	 	heme	 	chemical - endogenous mammalian	 	0.688	bias	0.266	0.118	1.28E-02	ALAS1,CYBB,FECH,HMOX1,SLC48A1	 	
P3	 	mir-183	-4.241	microrna	 	-1.122	bias	-0.394	-0.257	1.28E-02	EGR1,SEL1L,SLC30A1,SLC39A1,SLC39A3	 	
P3	 	CLEC11A	-1.140	growth factor	 	0.728	bias	0.463	-0.283	1.30E-02	ALDOA,ALOX5AP,ANXA1,BCL2L1,CPA3,CXCL12,FOS,NR4A1,TACR1,TKT	 	
P3	 	PLAG1	4.300	transcription regulator	Activated	2.057	bias	0.478	0.562	1.30E-02	ATF5,CD300C,EFNB1,FLNC,NPTXR,PIR,PLAG1,PTP4A3,QSOX1,TPSAB1/TPSB2	 	
P3	 	ELK4	1.328	transcription regulator	 	 	 	 	 	1.30E-02	EGR1,FOS,JUNB,NR4A1	 	
P3	 	FH	2.062	enzyme	 	 	 	 	 	1.30E-02	AKR1C1/AKR1C2,HMOX1,NQO1,TKT	 	
P3	 	IL16	-1.083	cytokine	 	0.747	bias	0.592	 	1.30E-02	BCL2L1,CD4,CMA1,FOS	 	
P3	 	L-histidine	 	chemical - endogenous mammalian	 	-0.865	bias	-0.473	0.062	1.30E-02	ASNS,ATF4,CEBPB,EGR1	 	
P3	 	liquiritigenin	 	chemical - endogenous non-mammalian	 	1.982	 	0.065	1.855	1.30E-02	ABCB11,EPHX1,FOS,HMOX1	 	
P3	 	methylene blue	 	chemical drug	 	0.343	 	-0.194	0.675	1.30E-02	APP,MAPT,NQO1,TXNRD1	 	
P3	 	STAT5A	-1.465	transcription regulator	 	0.364	 	0.155	-0.241	1.30E-02	ADIPOQ,AKR1C3,BCL2L1,CCND2,CCND3,CD68,CDK6,CEBPB,CYP1B1,EGLN3,EIF1AY,ERAP2,ESR2,FAS,FCER1G,FKBP14,FOS,FOSB,KIT,MAF,MAL2,MYH1,OAS1,PPFIBP2,RARRES3,SETBP1,SNTB1,SOCS3,SREBF1,TNFRSF1A,TPM3,TRAF3,WARS,YWHAG	 	
P3	 	8-bromoguanosine 3',5'-cyclic monophosphate	 	chemical - kinase inhibitor	 	0.522	 	0.222	-0.057	1.34E-02	FOS,HINT1,HLCS,HMOX1,JUNB,MMP9,VCAM1	 	
P3	 	ELF4	-1.003	transcription regulator	 	1.219	bias	0.331	0.353	1.34E-02	DUSP1,KIT,KLF2,KLF4,LYZ,NDUFS8,SPP1	 	
P3	 	methylnitrosourea	 	chemical toxicant	 	 	 	 	 	1.34E-02	EGR1,GSTP1,MNAT1,PSME1,RPS11,RPS12,SOD1	 	
P3	 	sodium orthovanadate	 	chemical reagent	Activated	2.581	 	0.222	2.008	1.34E-02	BCL2L1,ERBB4,HIF1A,MAP3K1,MSR1,RAB4A,SLC2A5	 	
P3	 	miR-124-3p (and other miRNAs w/seed AAGGCAC)	 	mature microrna	Inhibited	-4.310	bias	-0.710	 	1.35E-02	APEX2,ARPC1B,BTG3,CDK6,CERS2,CTGF,CYP1B1,DCTD,DNAJC1,EGR1,ELOVL1,ERH,HADHB,HTATIP2,IFRD2,LIMCH1,LITAF,MMP9,MTPN,OAF,PLOD3,RHOG,RNPEPL1,SLC16A1,SOX9,STX10,SYNGR2,SYPL1,UHMK1	 	
P3	 	BRCA1	1.330	transcription regulator	 	1.158	 	0.213	0.227	1.36E-02	ACTB,AK1,BCL2L1,CTSD,CYP1B1,DDIT3,DUSP3,EGR1,FAS,FKBP5,GDF15,HMOX1,HSD11B2,KIT,MLH1,NFE2L2,NQO1,PLTP,RRM2B,SERPINE2,TP63,UBE2I,XRCC6	 	
P3	 	EGR1	-4.547	transcription regulator	Activated	2.232	bias	0.519	 	1.36E-02	CCND2,CSF1,DUSP4,EGR1,FAS,FTL,GDF15,HMOX1,JUNB,LYZ,ME1,MMP14,MMP9,NAB2,NR4A1,PDGFA,PEG10,PLAU,SLC4A2,SOD1,SPP1,THBS1,VCAM1	 	
P3	 	PAX7	-3.518	transcription regulator	 	0.853	bias	0.680	 	1.36E-02	ASS1,C1QTNF3,CDH11,GALNT13,HMGN1,KCNK2,LRFN5,MYO1D,NQO1,RAD23B,RNH1,SEMA3E	 	
P3	 	cobalt chloride	 	chemical reagent	 	0.895	bias	0.507	 	1.36E-02	ALDOA,BHLHE41,DUSP1,HIF1A,HMOX1,HSD11B2,HSP90AB1,LEP,PKM,SORL1,TFRC,VDAC1	 	
P3	 	NFIC	1.386	transcription regulator	 	 	 	 	 	1.37E-02	ADAM12,ALDOA,CSF1,PDGFA,SLC25A5,TPO	 	
P3	 	ochratoxin A	 	chemical toxicant	 	-1.056	 	0.000	-1.056	1.37E-02	BCL2L1,FAS,GSTM5,GSTP1,MMP9,NQO1	 	
P3	 	IL10	-2.095	cytokine	 	0.723	 	0.076	0.264	1.38E-02	ALOX5AP,BCL2L1,BMP6,CCND2,CCND3,CD14,CD209,CD28,CD68,CD83,CDK6,CSF1,CSF1R,CTSB,CTSS,CXCL12,DUSP1,FAS,FCER1G,FCGR2A,FKBP5,FOS,HLA-G,HMOX1,HTATIP2,IGFBP4,IL10RA,IL1RN,IRAK1,KLRD1,MAF,MMP9,MSR1,PTX3,SHB,SOCS3,TACR1,TFRC,TNFRSF1A,TUBB4B,VCAM1	 	
P3	 	AGN194204	 	chemical drug	 	1.662	bias	0.628	 	1.41E-02	ANXA2,ARL4C,BZW2,CAMK2D,DUSP1,EMP1,GAPDH,GPR65,H2AFZ,ITGB2,LDB3,MKI67,MMP9,NSMAF,PLIN2,PRNP,SCD,SEMA4B,SLC3A2,SPP1,STIM1,TOP2A	 	
P3	 	KDM5B	1.168	transcription regulator	 	-1.109	bias	-0.341	0.248	1.42E-02	ARL6IP5,CTGF,DDIT3,DPY19L1,EGR1,FGFR2,FHL1,FST,GJB2,LIMCH1,MCAM,MPC1,PIR,PSME3,SNRPD1,SOX9,TGFB2,TOP2A,TUBB2A	 	
P3	 	flutamide	 	chemical drug	 	-0.816	 	-0.114	-0.538	1.42E-02	CYP1B1,CYP4B1,CYR61,ESR2,FOS,HIF1A,ME1,MKI67,NQO1,NR4A1,ODC1	 	
P3	 	PCGEM1	 	other	 	1.976	bias	0.528	 	1.45E-02	ALDOA,ENO1,FH,GAPDH,OGDH,PGD,PKM,TALDO1	 	
P3	 	SMAD1	-1.803	transcription regulator	 	0.626	bias	0.577	 	1.45E-02	ALPL,BCL2L1,BTG2,CSF1,CTGF,PDGFA,SOX9,SPP1	 	
P3	 	IL17A	-1.238	cytokine	 	1.018	bias	0.510	 	1.45E-02	ACTB,CD14,CD68,CD83,CEBPB,CTGF,CXCL12,CYR61,EDIL3,FAS,FMO1,FOS,HSPB8,IL1RN,KLF2,LEP,MMP9,NFKBIZ,PLAU,PTGFR,SOCS3,SREBF1,TP63,TYMP,VCAM1,YWHAG	 	
P3	 	di(2-ethylhexyl) phthalate	 	chemical toxicant	 	-1.622	 	0.245	-2.373	1.47E-02	BSG,CCND2,CYP4A11,EGR1,FOS,FOSB,POR,SOD1,SREBF1,TSPO	 	
P3	 	Mapk	 	group	 	0.493	bias	0.631	 	1.47E-02	ADAM12,APP,BCL2L1,CEBPB,CYBB,EGR1,FOS,HMOX1,JUNB,LEP,MMP9,SNCG,SOD1,SPP1,VCAM1	 	
P3	 	ATG7	1.556	enzyme	 	-0.517	 	-0.136	-0.114	1.48E-02	ATF4,BMF,CTGF,CTSB,GSTM5,MSR1,NQO1,SOCS3,TNFRSF1A	 	
P3	 	15-E2-isoketal modified phosphatidylethanolamine	 	chemical reagent	 	 	 	 	 	1.50E-02	DDIT3,HSPA5,VCAM1	 	
P3	 	AKIRIN2	1.576	other	 	 	 	 	 	1.50E-02	CCND2,DUSP1,MMP9	 	
P3	 	BRMS1	1.672	enzyme	 	 	 	 	 	1.50E-02	GJB2,PLAU,SPP1	 	
P3	 	IGFBP4	2.678	other	 	 	 	 	 	1.50E-02	IGFBP3,IGFBP6,MCAM	 	
P3	 	KDM3A	-1.043	transcription regulator	 	 	 	 	 	1.50E-02	GDF15,HMOX1,LEP	 	
P3	 	MRPL12	2.762	other	 	 	 	 	 	1.50E-02	MT-ND1,MT-RNR1,SYPL1	 	
P3	 	Muscarinic cholinergic receptor	 	group	 	 	 	 	 	1.50E-02	ALPL,CYR61,FOS	 	
P3	 	P2RY1	-1.178	g-protein coupled receptor	 	 	 	 	 	1.50E-02	FOS,LEP,VCAM1	 	
P3	 	PPP1CA	1.719	phosphatase	 	 	 	 	 	1.50E-02	CTGF,FOS,SPP1	 	
P3	 	SAV1	1.147	other	 	 	 	 	 	1.50E-02	CTGF,GPC3,SPP1	 	
P3	 	SCGB3A2	-3.769	other	 	 	 	 	 	1.50E-02	CTSD,CTSS,MMP14	 	
P3	 	TARBP2	-1.427	other	 	 	 	 	 	1.50E-02	MAF,RET,THBS1	 	
P3	 	TSPO	2.020	transmembrane receptor	 	 	 	 	 	1.50E-02	TSPO,VCAM1,VDAC1	 	
P3	 	miR-494-3p (miRNAs w/seed GAAACAU)	 	mature microrna	 	 	 	 	 	1.50E-02	HMOX1,KIT,SCN3A	 	
P3	 	SB-431542	 	chemical reagent	 	-0.961	bias	-0.266	-0.007	1.57E-02	BMP6,CD14,CTGF,DVL3,FOLR2,FOS,GJB2,PTPRK,SCN7A,SPP1,TGFB2,TNFRSF12A,XYLT1	 	
P3	 	BMS-690514	 	chemical drug	 	-1.890	bias	-0.323	-1.036	1.58E-02	CCND3,CYCS,DDIT3,HSPA4,HSPA8,HSPE1,HSPH1	 	
P3	 	tempol	 	chemical drug	 	-1.969	bias	-0.355	-1.043	1.58E-02	BCL2L1,CYCS,MMP9,MT-CO1,SPP1,UCP2,VCAM1	 	
P3	 	EFNA1	-2.051	other	 	-0.333	 	-0.166	0.164	1.59E-02	CLDN2,CTGF,DUSP4,DUSP6,ETV5,HRAS,PLAT,SLC20A1,SOX9,TRIM2,USP9Y	 	
P3	 	NEUROG1	-13.485	transcription regulator	 	0.000	 	-0.147	0.463	1.59E-02	ASS1,CCND2,DSP,LCP1,MFAP4,MMP9,NEO1,P4HA2,SULF1,TACR1,THBS1	 	
P3	 	miR-30c-5p (and other miRNAs w/seed GUAAACA)	 	mature microrna	Inhibited	-3.330	bias	-0.710	 	1.60E-02	CTGF,MAP4K4,MAT2A,MPDU1,P4HA2,PAFAH1B2,PTPRK,PTRH1,RAD23B,SLC38A1,SLC4A7,SLC7A1,SLC7A11,SYPL1,TMED3,UBE2I	 	
P3	 	tacrolimus	 	chemical drug	 	-1.716	 	-0.224	-0.677	1.61E-02	APP,BCL2L1,CYBB,EGR1,F5,FKBP5,FLNA,FOS,FOSB,GNPDA1,HSPD1,JUNB,KLRD1,MAF,MARCKSL1,NME1,NR4A1,ODC1,PLIN2,PRNP,SDC3,SDCBP,SIAH2,SPP1,TNFRSF12A	 	
P3	 	ADCY	 	group	 	1.000	bias	0.459	0.081	1.62E-02	CRYM,CYP1B1,FOS,LEP,TXN	 	
P3	 	NADPH oxidase	 	complex	 	1.387	bias	0.459	0.367	1.62E-02	CYBB,FOS,HMOX1,MMP9,VCAM1	 	
P3	 	ezetimibe	 	chemical drug	Activated	2.216	bias	0.444	1.232	1.62E-02	APOB,HMGCS1,MVD,PMVK,SREBF2	 	
P3	 	miR-486-5p (and other miRNAs w/seed CCUGUAC)	 	mature microrna	 	-1.432	bias	-0.710	 	1.62E-02	AFF3,CREBL2,EMP1,PIK3AP1,TWF1	 	
P3	 	mir-486	 	microrna	 	-1.342	bias	-0.710	 	1.62E-02	AFF3,CREBL2,EMP1,PIK3AP1,TWF1	 	
P3	 	TP63	-4.135	transcription regulator	Activated	3.936	bias	0.286	2.503	1.64E-02	ADRM1,ANOS1,ATG9A,BCL2L1,CCND2,CCND3,CDC42,CDK6,CECR1,CSTA,CTSD,CYR61,DUSP10,DUSP6,EMP1,FAS,FGFR2,FOS,FST,GAPDH,HSPA8,IGFBP3,IGFBP6,JUNB,KCNG1,MAP2K3,MLH1,PCNXL2,PLAU,POLD2,PRNP,RBBP8,REXO4,SEPHS1,SH2B3,SLC7A11,THBS1,TMBIM6,TNFRSF1A,TP63,TPP1	 	
P3	 	n-nitrosomethylbenzylamine	 	chemical toxicant	 	 	 	 	 	1.64E-02	ALDH3A2,ANXA2,AOX1,BPIFB2,EIF4G2,FST,GCLM,GNG12,GSS,H2AFZ,HMOX1,LAMP2,MAP2K3,RAB1A,RABIF,RAD23B,SLC30A1,TTC1,TXNL1	 	
P3	 	TAF4B	1.114	transcription regulator	 	0.068	bias	0.710	 	1.66E-02	CCND2,CTGF,FST,RET,SPP1,ZBTB16	 	
P3	 	anakinra	 	biologic drug	 	 	 	 	 	1.66E-02	GRINA,HMOX1,MAP2K3,PHB,VCAM1,VWA5A	 	
P3	 	xanthohumol	 	chemical - endogenous non-mammalian	 	0.000	bias	-0.516	 	1.66E-02	ANXA1,DGAT2,FOS,GAB2,HMOX1,NQO1	 	
P3	 	D-galactosamine	 	chemical - endogenous mammalian	 	0.573	bias	0.598	 	1.67E-02	CD14,CTSB,FOS,GDF15,JUNB,NFE2L2,SDC3,TNFRSF1A	 	
P3	 	KDR	1.205	kinase	 	-0.283	bias	0.533	 	1.67E-02	ANXA2,EPHB3,HMOX1,MMP14,NME1,NME2,NR4A1,SFRP1	 	
P3	 	nonylphenol	 	chemical toxicant	 	0.707	bias	0.572	 	1.67E-02	ADIPOQ,ALAS1,APOB,ATP6AP1,FAS,RPH3A,RPN2,SLC1A5	 	
P3	 	SFTPA1	-3.870	transporter	 	0.577	 	-0.243	1.420	1.67E-02	AKR1C1/AKR1C2,AMOT,CTGF,CYP1B1,CYR61,EGR1,FOS,FOSB,KLF2,MAP1B,PLIN2,SFRP2	 	
P3	 	cyclophosphamide	 	chemical drug	 	0.085	bias	0.387	-1.170	1.67E-02	CAPN6,FAS,FCGR2A,FOS,GAS5,ODC1,S100A11,SOX9,SPP1,THBS1,TNFRSF12A,UGCG	 	
P3	 	MAPK1	1.606	kinase	 	-0.300	 	-0.026	-0.152	1.68E-02	ADAM12,ADAM17,APOE,CAPN2,CHST2,COX17,CSTA,CTGF,CTSB,DAB2,DUSP1,EGLN3,EGR1,EMP1,ERP29,FLNC,FOS,FOSB,GBP1,GNG2,HMOX1,IL1RN,ITGAV,JUNB,LZTS2,MBP,MMP9,NFE2L2,NUPR1,OAS1,PLAU,PTPRK,SFRP2,SHANK2,SLC4A7,SPP1,SPRY4,UBE2I,USP18	 	
P3	 	LGALS1	1.610	other	 	0.946	bias	0.444	-0.351	1.69E-02	CCND2,CXCL16,FIS1,HLA-G,HRAS,LEP,MAF,MMP9,PTX3	 	
P3	 	ATF2	1.160	transcription regulator	 	1.519	bias	0.682	 	1.72E-02	ACTB,ASNS,DDIT3,DUSP1,DUSP10,EGR1,FOS,MAT2A,NUPR1,PCK1,PLAU,TGFB2,VCAM1	 	
P3	 	CFTR	-3.990	ion channel	 	0.913	 	-0.056	1.097	1.72E-02	ASNS,CAPG,CFTR,CPA3,CUBN,CYP4A11,FAS,HDAC2,NFKBIZ,POR,SAA1,SCD,SOCS3	 	
P3	 	MKL2	-1.362	transcription regulator	 	-1.667	bias	-0.446	-0.329	1.72E-02	ACTB,BCL2L1,CD151,CMA1,CPA3,CTSG,FLNA,G0S2,GSTM5,HLA-A,LTF,OSCP1,SLC20A1	 	
P3	 	AK1	2.136	kinase	 	 	 	 	 	1.76E-02	AK1,ENO1,GAPDH,PKM	 	
P3	 	MLX	1.459	transcription regulator	 	 	 	 	 	1.76E-02	ARRDC4,MID1IP1,SCD,THRSP	 	
P3	 	PLCG1	1.195	enzyme	 	1.120	 	0.237	0.651	1.76E-02	CCND3,EGR1,FOS,THBS1	 	
P3	 	TLE1	-1.954	transcription regulator	 	 	 	 	 	1.76E-02	DUSP1,EGR1,FOS,NUPR1	 	
P3	 	clasto-lactacystin beta-lactone	 	chemical - protease inhibitor	 	1.966	bias	0.710	 	1.76E-02	ATF4,DDIT3,GSTP1,PRKCE	 	
P3	 	formoterol	 	chemical drug	 	-1.214	bias	-0.284	-0.651	1.76E-02	CALR,MMP9,PSMA3,PSMA4	 	
P3	 	galactose	 	chemical - endogenous mammalian	 	1.000	bias	0.601	 	1.76E-02	COX5A,SREBF1,THBS1,VDAC1	 	
P3	 	gamma-linolenic acid	 	chemical - endogenous mammalian	 	0.000	 	-0.055	0.109	1.76E-02	HMOX1,PLIN2,PLIN5,THRSP	 	
P3	 	prazosin	 	chemical drug	Activated	2.000	bias	-0.710	 	1.76E-02	DUSP1,EGR1,FOS,NR4A1	 	
P3	 	PTGS2	-5.555	enzyme	 	1.274	bias	0.369	-0.162	1.77E-02	ANXA1,ANXA2,BCL2L1,CD68,CTSD,CXCL12,CXCL14,CYP1B1,DUSP1,DYNLL1,EGR1,FOS,IGFBP3,ITGAV,LEP,MKI67,MMP14,MMP9,MSR1,RPS19,RPS3A	 	
P3	 	ARNT2	-1.047	transcription regulator	Activated	3.138	bias	0.710	 	1.83E-02	AKR1B1,AOX1,APOE,BAG6,EGR1,EIF5A,FCGR2A,FKBP3,GLUL,HLA-A,ICMT,IGFBP4,LAMA2,LCP1,LTF,MRPL37,MSC,MTPN,NAP1L4,NDUFA1,OAZ1,PEA15,PFN1,PLP1,SIM1,TYROBP	 	
P3	 	POU2F1	1.300	transcription regulator	 	 	 	 	 	1.85E-02	AOX1,ATP6V0C,CSF1R,GAS5,GCLM,GSTM3,GSTM4,GSTM5,LY6E,MYH1,PDRG1,SAA1,SESN2,SLC7A11,SOD1,SPP1,VCAM1	 	
P3	 	green tea polyphenol	 	chemical drug	 	-0.522	 	-0.178	-0.059	1.85E-02	ADIPOQ,ANXA1,FOS,HMOX1,IGFBP3,MMP9,PLAU	 	
P3	 	honokiol	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.85E-02	ADIPOQ,BCL2L1,CCND2,CDK6,FOS,JUNB,MMP9	 	
P3	 	temozolomide	 	chemical drug	 	-0.562	 	0.069	-0.713	1.85E-02	BCL2L1,DDIT3,FAS,ITGAV,MMP14,MMP9,TP63	 	
P3	 	Ca2+	 	chemical - endogenous mammalian	 	1.600	bias	0.385	-0.297	1.86E-02	ADCYAP1,APP,BCL2L1,CALR,CCND2,CCND3,CD83,CDC42,CEBPB,CYP1B1,CYR61,DDIT3,DES,DUSP1,EGR1,FGFR2,FOS,HSPA5,JUNB,KCNG1,KLF4,MCAM,MMP9,MSR1,NR1D1,NR4A1,ODC1,PEBP1,SPP1,SREBF2,UGCG	 	
P3	 	ADAM10	1.509	peptidase	 	 	 	 	 	1.89E-02	APP,CALCRL,CSF1,CXCL12,CXCL16,DCLK1,FOS,GNA13,IRAK1,PLP1,PRNP,RABEP1,SOX9	 	
P3	 	CTGF	-3.250	growth factor	 	-0.181	bias	0.385	-1.633	1.90E-02	ADAMTS5,BCL2L1,COL8A1,CTGF,DAD1,EGLN3,EGR1,ENO1,HIF1A,LIMS1,MMP14,MMP9,P4HA1,PTGFR,SDC4	 	
P3	 	TNFSF10	-1.625	cytokine	 	0.191	 	0.129	-0.277	1.90E-02	BCL2L1,CD14,CTSB,FOS,FTH1,HLA-A,IL1RN,MMP9,PLAU,PRKCE,SERPINH1,TAF6,TFRC,TP63	 	
P3	 	(S)-duloxetine	 	chemical drug	 	 	 	 	 	1.90E-02	ACTB,HDAC2	 	
P3	 	3,4-dihydroxybenzaldehyde	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	CCND2,PARK7	 	
P3	 	3,4-methylenedioxyamphetamine	 	chemical drug	 	 	 	 	 	1.90E-02	BCL2L1,EIF4G2	 	
P3	 	ACS84	 	chemical reagent	 	 	 	 	 	1.90E-02	GCLM,HMOX1	 	
P3	 	AKAP13	-1.100	other	 	 	 	 	 	1.90E-02	FKBP5,FOS	 	
P3	 	ALPL	6.779	phosphatase	 	 	 	 	 	1.90E-02	ALPL,SPP1	 	
P3	 	Akr1b7	 	enzyme	 	 	 	 	 	1.90E-02	ADIPOQ,LEP	 	
P3	 	Ap1 gamma	 	group	 	 	 	 	 	1.90E-02	CD28,HLA-A	 	
P3	 	BCAT2	1.468	enzyme	 	 	 	 	 	1.90E-02	ADIPOQ,LEP	 	
P3	 	C1QL1	-2.404	other	 	 	 	 	 	1.90E-02	FOS,NR4A1	 	
P3	 	CCKAR	-3.846	g-protein coupled receptor	 	 	 	 	 	1.90E-02	EGR1,LEP	 	
P3	 	CTH	-2.212	enzyme	 	 	 	 	 	1.90E-02	DDIT3,HSPA5	 	
P3	 	CYTH1	1.048	other	 	 	 	 	 	1.90E-02	ARF1,ARF6	 	
P3	 	DNAJC3	1.134	other	 	 	 	 	 	1.90E-02	ATF4,DDIT3	 	
P3	 	Dynamin	 	group	 	 	 	 	 	1.90E-02	FOS,ITGAV	 	
P3	 	EDEM1	2.437	enzyme	 	 	 	 	 	1.90E-02	DDIT3,HSPA5	 	
P3	 	EEF2K	-1.773	kinase	 	 	 	 	 	1.90E-02	BCL2L1,MAP1B	 	
P3	 	EIF2B1	1.691	translation regulator	 	 	 	 	 	1.90E-02	ATF4,DDIT3	 	
P3	 	ELOVL2	-3.917	enzyme	 	 	 	 	 	1.90E-02	SCD,SREBF1	 	
P3	 	Esr1-Estrogen-Sp1	 	complex	 	 	 	 	 	1.90E-02	CTSD,FOS	 	
P3	 	FTL	5.285	enzyme	 	 	 	 	 	1.90E-02	FTH1,TFRC	 	
P3	 	Fetal Hemoglobin	 	complex	 	 	 	 	 	1.90E-02	HIF1A,HMOX1	 	
P3	 	GFRA2	-1.026	transmembrane receptor	 	 	 	 	 	1.90E-02	EGR1,FOSB	 	
P3	 	HIST1H1A	4.179	other	 	 	 	 	 	1.90E-02	FOS,GLB1	 	
P3	 	Integrin alpha 4 beta 1	 	complex	 	 	 	 	 	1.90E-02	BCL2L1,MMP14	 	
P3	 	MPO	-2.839	enzyme	 	 	 	 	 	1.90E-02	APP,EDNRB	 	
P3	 	NEU1	1.519	enzyme	 	 	 	 	 	1.90E-02	DGAT2,SREBF2	 	
P3	 	PFN1	2.274	other	 	 	 	 	 	1.90E-02	ANXA2,VCAM1	 	
P3	 	PQQ cofactor	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	HMOX1,NFE2L2	 	
P3	 	RAB7A	2.034	enzyme	 	 	 	 	 	1.90E-02	EGR1,FOS	 	
P3	 	SPTBN1	-1.574	other	 	 	 	 	 	1.90E-02	BCL2L1,FOS	 	
P3	 	TMBIM1	1.496	other	 	 	 	 	 	1.90E-02	FAS,MMP9	 	
P3	 	TUBB1	-6.043	other	 	 	 	 	 	1.90E-02	TUBB,TUBB2A	 	
P3	 	VDAC1	2.373	ion channel	 	 	 	 	 	1.90E-02	APP,VDAC1	 	
P3	 	acriflavine	 	chemical toxicant	 	 	 	 	 	1.90E-02	ADIPOQ,SOCS3	 	
P3	 	actinomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	IGFBP4,SAA1	 	
P3	 	ampelopsin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	HMOX1,HSPA5	 	
P3	 	benfotiamine	 	chemical drug	 	 	 	 	 	1.90E-02	AKR1B1,TKT	 	
P3	 	bongkrekic acid	 	chemical toxicant	 	 	 	 	 	1.90E-02	CYCS,VCAM1	 	
P3	 	chlordecone	 	chemical toxicant	 	 	 	 	 	1.90E-02	HSPA5,LTF	 	
P3	 	dobutamine	 	chemical drug	 	 	 	 	 	1.90E-02	HMOX1,LEP	 	
P3	 	ergosterol-5,8-peroxide	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	CTGF,VCAM1	 	
P3	 	exemestane	 	chemical drug	 	 	 	 	 	1.90E-02	HMOX1,NQO1	 	
P3	 	ezatiostat	 	chemical drug	 	 	 	 	 	1.90E-02	ABCC1,GCLM	 	
P3	 	myristoylated PKCzeta pseudosubstrate peptide inhibitor	 	chemical - kinase inhibitor	 	 	 	 	 	1.90E-02	ABCB11,VCAM1	 	
P3	 	pentosan polysulfate	 	chemical drug	 	 	 	 	 	1.90E-02	MMP9,PRNP	 	
P3	 	phenol derivative	 	chemical toxicant	 	 	 	 	 	1.90E-02	HMOX1,NFE2L2	 	
P3	 	phloretin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	ADIPOQ,HMOX1	 	
P3	 	pituitary adenylate cyclase-activating polypeptide	 	biologic drug	 	 	 	 	 	1.90E-02	CCND2,CCND3	 	
P3	 	prochloraz	 	chemical reagent	 	 	 	 	 	1.90E-02	CYP1B1,ODC1	 	
P3	 	ropivacaine	 	chemical drug	 	 	 	 	 	1.90E-02	MBP,VDAC2	 	
P3	 	silver nitrate	 	chemical drug	 	 	 	 	 	1.90E-02	HMOX1,SAA1	 	
P3	 	trimethyloxamine	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.90E-02	ATF4,DDIT3	 	
P3	 	vaccenic acid	 	chemical - endogenous mammalian	 	 	 	 	 	1.90E-02	PLIN2,PLIN5	 	
P3	 	yohimbine	 	chemical drug	 	 	 	 	 	1.90E-02	EGR1,FOS	 	
P3	 	FYN	1.200	kinase	 	-0.480	 	0.194	-1.008	1.91E-02	DUSP1,FOS,HMOX1,MBP,NFE2L2,NQO1,NQO2,PLP1,SOCS3	 	
P3	 	deoxycholate	 	chemical - endogenous mammalian	 	1.756	 	-0.072	1.970	1.91E-02	ABCB11,CYP4A11,DDIT3,EGR1,GJB2,GLUL,HSPA5,PLAU,TP63	 	
P3	 	BAPTA-AM	 	chemical reagent	 	0.581	bias	-0.473	1.896	1.92E-02	DDIT3,EGR1,FOS,HSPA5,NR4A1,SOCS3,SPP1,VCAM1	 	
P3	 	D-fructose	 	chemical - endogenous mammalian	 	0.730	bias	0.671	 	1.92E-02	ADIPOQ,CD68,SCD,SLC2A5,SREBF1,THBS1,TKT,TXN2	 	
P3	 	TYROBP	4.086	transmembrane receptor	 	1.131	bias	0.444	0.253	1.92E-02	CD83,KLRD1,NCKAP1L,SH2B3,SLC1A5,SPP1,TREM2,TYROBP	 	
P3	 	chloropromazine	 	chemical drug	 	-0.412	bias	0.273	-1.006	1.92E-02	CD83,FNDC4,FOS,HMGCS1,MSMO1,NR4A1,SCD,SREBF2	 	
P3	 	phenacetin	 	chemical drug	 	1.941	bias	0.642	 	1.92E-02	ANXA1,ANXA2,CAPN6,GAS5,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A	 	
P3	 	MAPK3	1.561	kinase	 	-0.444	bias	0.539	 	1.97E-02	CSTA,DUSP4,EGR1,FOS,FOSB,JUNB,MMP9,SLC4A7,SOD1,SPP1,THBS1	 	
P3	 	CCR1	2.248	g-protein coupled receptor	 	0.186	bias	0.312	-0.569	1.99E-02	ATF4,CTSS,FOS,ITGAV,MMP9,SPP1	 	
P3	 	THBS4	2.015	other	Activated	2.402	bias	0.289	1.707	1.99E-02	ATF4,CALR,HSPA5,HYOU1,TGFB2,VCAM1	 	
P3	 	diallyl disulfide	 	chemical - endogenous non-mammalian	Activated	2.205	bias	0.507	 	1.99E-02	ABCC3,GDF15,GSTM5,HMOX1,NFE2L2,NQO1	 	
P3	 	dithiothreitol	 	chemical reagent	 	0.646	bias	0.401	-0.228	1.99E-02	DDIT3,HIF1A,HMOX1,HSPA5,PTGES2,SEL1L	 	
P3	 	ETS	 	group	 	 	 	 	 	2.01E-02	C3AR1,CHI3L1,DAB2,EGR1,FOS	 	
P3	 	F10	-1.159	peptidase	 	-1.372	bias	0.262	-1.955	2.01E-02	CTGF,CYR61,DUSP10,EGR1,VCAM1	 	
P3	 	FGFR4	-3.494	kinase	 	 	 	 	 	2.01E-02	BCL2L1,FOS,LPAR1,MMP14,PLAU	 	
P3	 	PPP1R15A	-1.110	other	 	0.283	 	0.055	0.175	2.01E-02	ATF4,CEBPB,DDIT3,EIF2S1,HSPA5	 	
P3	 	apigenin	 	chemical - endogenous non-mammalian	Inhibited	-2.927	bias	-0.511	 	2.03E-02	BCL2L1,CCND2,CDK6,DGAT2,DVL1,DVL3,FOS,GCLM,HIF1A,HMOX1,MMP9,VCAM1	 	
P3	 	GPD1	1.593	enzyme	 	 	 	 	 	2.07E-02	ALPL,ANXA2,APP,ASNS,C6,CD63,FADS3,FAM129A,MMEL1,MTHFD1L,NQO1,PFKFB3,PSAT1,SERPINE2	 	
P3	 	H2AFB3 (includes others)	 	other	 	1.000	bias	0.710	 	2.16E-02	ATF5,CHAC1,DCLK1,DHRS9,FOS,MMEL1,SAA1,SAA2,SLC29A3	 	
P3	 	L-methionine	 	chemical - endogenous mammalian	 	0.000	 	-0.065	0.157	2.16E-02	DDIT3,EEF1A1,HSPA5,IGFBP4,MAT2A,PCK2,PLAT,SPP1,TOP2A	 	
P3	 	miR-133a-3p (and other miRNAs w/seed UUGGUCC)	 	mature microrna	Inhibited	-2.224	bias	-0.710	 	2.16E-02	ARHGDIA,ARL3,CERS2,CTGF,FSCN1,FTL,LASP1,PKM,PTPRK	 	
P3	 	phorbol 12,13-dibutyrate	 	chemical - endogenous non-mammalian	 	-0.626	 	0.222	-1.118	2.16E-02	APP,BCL2L1,CCND2,FOS,PRKCE,PRNP,SPRY4	 	
P3	 	Nr1h	 	group	 	1.426	bias	-0.262	2.547	2.17E-02	ACSL3,AGPAT1,ALDH1A2,APOC1,APOE,BMP6,CCND2,CSF1,FECH,FGF1,MARCKSL1,NFKBIZ,NR5A2,PLTP,SCD,SFRP1,SREBF1,THBS1,ZBTB16	 	
P3	 	ITGB3	-1.226	transmembrane receptor	 	0.142	bias	0.255	-0.560	2.18E-02	APLP2,BCL2L1,CSF1,FOS,ITGAV,LIMS1,MMP14,MMP9,PLAU,SDHC,UBA52	 	
P3	 	SPDEF	-3.094	transcription regulator	 	-1.117	bias	-0.461	0.334	2.18E-02	CDH11,COL16A1,COL5A2,COL6A1,CTGF,DKK3,HIF1A,LASP1,PLAU,SOX17,SQSTM1	 	
P3	 	black raspberry extract	 	chemical drug	 	 	 	 	 	2.19E-02	ALDH3A2,ANXA2,AOX1,BPIFB2,EIF4G2,FST,GNG12,H2AFZ,HMOX1,LAMP2,MAP2K3,RAB1A,RAD23B,SLC30A1,TTC1,TXNL1	 	
P3	 	ABCB6	1.560	transporter	Inhibited	-2.770	 	0.050	-2.907	2.20E-02	CYP4A11,CYP4B1,FECH,HK1,HMBS,SLC25A39,SLC25A51,UROS	 	
P3	 	EFNA3	1.543	kinase	 	-0.707	 	-0.149	-0.287	2.20E-02	CTGF,DUSP4,DUSP6,ETV5,PLAT,SLC20A1,SOX9,TRIM2	 	
P3	 	mir-133	-1.660	microrna	 	-1.547	bias	-0.575	 	2.20E-02	CCND2,CDC42,CTGF,FSCN1,GSTP1,HLA-G,LASP1,MMP14	 	
P3	 	NCOA1	1.095	transcription regulator	 	0.645	 	0.037	0.529	2.23E-02	ABCB11,ADIPOQ,DGKQ,FGFR2,GJB2,LEP,LYZ,MAPK8IP2,MNAT1,NFKBIZ,PCK1,RPL36,SORBS1,SREBF1,THRSP	 	
P3	 	lithium chloride	 	chemical drug	 	-0.154	bias	0.328	-1.364	2.23E-02	APP,ASS1,BSG,CD4,FOS,FSCN1,GDF15,GSK3B,HMOX1,MAPK10,MAPT,PLIN2,PTX3,SOX9,TMEM2	 	
P3	 	RHOA	1.367	enzyme	 	1.377	bias	0.268	0.507	2.24E-02	ANLN,BCL2L1,CEBPB,CTGF,CTSD,FOS,GDF15,MMP14,MMP9,PLAU,SOX9,VCAM1	 	
P3	 	ascorbic acid	 	chemical - endogenous mammalian	 	-0.093	 	0.066	-0.304	2.24E-02	ALPL,BCL2L1,BMF,DDIT3,FAS,HIF1A,HSPA5,IGFBP3,IGFBP4,ITGAV,SLC20A1,SPP1	 	
P3	 	hydrocortisone	 	chemical - endogenous mammalian	 	-0.268	 	0.074	-0.558	2.24E-02	CCND2,CCND3,CDH11,CEBPB,CTGF,ERP29,FAS,GBP1,GLUL,HSPD1,IGFBP3,IGFBP4,IGFBP6,NDUFA6,PROX1,SMPD2,STC2,TUBB	 	
P3	 	6-amino-4-(4-phenoxyphenylethylamino)quinazoline	 	chemical reagent	 	 	 	 	 	2.25E-02	APOE,ITGAV,MMP9	 	
P3	 	ABCC1	3.301	transporter	 	 	 	 	 	2.25E-02	CYBB,NFE2L2,NQO1	 	
P3	 	ADGRF5	-1.387	g-protein coupled receptor	 	 	 	 	 	2.25E-02	CSF1,IL1RN,MMP9	 	
P3	 	ASXL1	1.073	transcription regulator	 	 	 	 	 	2.25E-02	HOXA10,HOXA6,HOXA7	 	
P3	 	ATF5	10.438	transcription regulator	 	 	 	 	 	2.25E-02	GAS5,SAA1,SAA2	 	
P3	 	BACE1	1.333	peptidase	 	 	 	 	 	2.25E-02	APP,MBP,PLP1	 	
P3	 	GAL3ST1	-5.487	enzyme	 	 	 	 	 	2.25E-02	MBP,PCK1,SLC38A3	 	
P3	 	GCS-100	 	chemical drug	 	 	 	 	 	2.25E-02	BCL2L1,CCND2,CDK6	 	
P3	 	L-type Calcium Channel	 	complex	 	 	 	 	 	2.25E-02	APOE,EGR1,FOS	 	
P3	 	N-propyl bromide	 	chemical reagent	 	 	 	 	 	2.25E-02	GCLM,HMOX1,NQO1	 	
P3	 	NCX-4040	 	chemical drug	 	 	 	 	 	2.25E-02	GCLM,GSTP1,NQO1	 	
P3	 	PBX2	1.308	other	 	 	 	 	 	2.25E-02	COL5A2,FOS,PLAU	 	
P3	 	PDGF (family)	 	group	 	 	 	 	 	2.25E-02	CALR,EEF1B2,HSPD1	 	
P3	 	PMP22	-1.246	other	 	 	 	 	 	2.25E-02	APOE,CSPG4,FLOT1	 	
P3	 	PNPLA8	1.084	enzyme	 	 	 	 	 	2.25E-02	HMOX1,HSPA5,NQO1	 	
P3	 	RP 73401	 	chemical toxicant	 	 	 	 	 	2.25E-02	BTG2,CEBPB,EGR1	 	
P3	 	Retinoic acid-RAR-RXR	 	complex	 	 	 	 	 	2.25E-02	DUSP1,IGFBP3,TGFB2	 	
P3	 	SH3KBP1	1.447	other	 	 	 	 	 	2.25E-02	BCL2L1,CCND2,HIF1A	 	
P3	 	SOAT1	1.424	enzyme	 	 	 	 	 	2.25E-02	APP,DDIT3,SREBF2	 	
P3	 	TEAD3	1.334	transcription regulator	 	 	 	 	 	2.25E-02	DES,MYH1,TP63	 	
P3	 	TH-302	 	chemical drug	 	 	 	 	 	2.25E-02	CCND2,CCND3,CDK6	 	
P3	 	TOP1	1.623	enzyme	 	 	 	 	 	2.25E-02	ASNS,GLB1,HIF1A	 	
P3	 	aristolochic acid I	 	chemical toxicant	 	 	 	 	 	2.25E-02	FOS,HMOX1,LEP	 	
P3	 	carnosol	 	chemical - endogenous non-mammalian	 	 	 	 	 	2.25E-02	GCLM,HMOX1,NFE2L2	 	
P3	 	coumestrol	 	chemical toxicant	 	 	 	 	 	2.25E-02	ESR2,FOS,HSP90AB1	 	
P3	 	oleoylethanolamide	 	chemical - endogenous mammalian	 	 	 	 	 	2.25E-02	BCL2L1,FOS,FOSB	 	
P3	 	JUNB	-3.788	transcription regulator	 	1.276	bias	0.452	0.098	2.31E-02	CD68,COMT,CYP1B1,DUSP1,FTH1,HMOX1,ITGAV,JUNB,LPAR1,MMP9,MVD,MYL12A,PLAU,PLIN1,SCD,SLC7A1,YWHAG	 	
P3	 	WNT1	1.937	cytokine	 	1.599	bias	0.484	0.005	2.31E-02	CCND2,CCND3,DNAJC1,EEF1A1,EFNB1,EGR1,EIF5A,FOS,GRN,ISLR,JUNB,KIT,LMX1A,LY6E,RNASE1,SIM1,SPP1	 	
P3	 	Cd2+	 	chemical toxicant	 	1.067	bias	0.568	 	2.31E-02	DDIT3,FOS,HMOX1,SOD1	 	
P3	 	GHRHR	-2.700	g-protein coupled receptor	 	 	 	 	 	2.31E-02	CCND3,FOS,GSK3B,HSD11B2	 	
P3	 	LAMC1	1.325	other	 	-1.067	bias	-0.406	-0.263	2.31E-02	CDH11,ETV5,MBP,TGFB2	 	
P3	 	NFkB (family)	 	group	 	 	 	 	 	2.31E-02	BCL2L1,BSG,MMP9,NCAM1	 	
P3	 	SURF1	2.835	enzyme	 	-1.000	bias	-0.710	 	2.31E-02	COX4I1,MT-CO1,NDUFA1,VDAC1	 	
P3	 	gallic acid	 	chemical - endogenous non-mammalian	 	-1.067	bias	-0.601	 	2.31E-02	ADAM17,MMP9,PLAT,VCAM1	 	
P3	 	ibrutinib	 	chemical drug	 	0.000	 	0.000	0.000	2.31E-02	BCL2L1,CDK6,FAS,UGCG	 	
P3	 	manganese	 	chemical - endogenous mammalian	 	 	 	 	 	2.31E-02	DDIT3,GAPDH,HSPA5,PARK7	 	
P3	 	pentobarbital	 	chemical drug	 	1.173	bias	-0.406	1.965	2.31E-02	FOS,FST,JUNB,NR4A1	 	
P3	 	spermidine	 	chemical - endogenous mammalian	 	1.000	 	0.194	0.613	2.31E-02	FOS,HMOX1,OAZ1,ODC1	 	
P3	 	xanthine	 	chemical - endogenous mammalian	 	1.067	bias	0.507	 	2.31E-02	DUSP1,DUSP10,MMP14,PLAU	 	
P3	 	TAZ	1.378	enzyme	 	 	 	 	 	2.31E-02	ADAMTS5,ANXA1,AOX1,CTGF,CYP1B1,CYR61,KIT,LCP1,MFAP5,PCLO	 	
P3	 	TFAP2C	-1.927	transcription regulator	 	-0.886	 	-0.191	-0.360	2.31E-02	ALCAM,ANLN,CTGF,FKBP4,FST,HK1,MBP,RET,SEMA3B,THBS1	 	
P3	 	S100A8	-2.550	other	 	-0.447	 	0.156	-1.146	2.33E-02	ADAMTS5,ALPL,BCL2L1,BMF,C1QB,CLEC9A,CPM,CXCL14,ETV5,FAS,FCGR2A,GJB2,HMOX1,KCNMA1,MYH1,NTRK3,PLAU,RAB20,SCUBE1,SEMA3B,USP18,VCAM1	 	
P3	 	crocidolite asbestos	 	chemical toxicant	 	0.080	bias	0.710	 	2.36E-02	BCAT1,FOS,GCLM,JUNB,SPP1,TNFRSF1A	 	
P3	 	formaldehyde	 	chemical - endogenous mammalian	 	-1.670	bias	0.646	 	2.36E-02	EGR1,FOS,FOSB,GABBR1,JUNB,MMP9	 	
P3	 	IL1	 	group	Activated	2.203	bias	0.454	-0.338	2.39E-02	ADAM17,ADAMTS5,AKR1C1/AKR1C2,APOE,APP,CHI3L1,CSF1,CSF1R,CTSB,CYP27A1,DUSP1,F2RL3,FAS,FOS,FST,FTH1,HIF1A,HMOX1,IL1RN,ITGB2,KIT,LEP,LYZ,MAP2K3,MMP9,NR1H3,ODC1,PANX1,PDGFA,SAA1,SAA2,SDC4,SOCS3,SOX9,SREBF1,TYMP,UGCG,VCAM1	 	
P3	 	FGF7	1.300	growth factor	 	1.962	bias	0.382	0.735	2.41E-02	ABCC3,APRT,BCL2L1,CSF1,ETV5,FGFR2,MMP9,NFE2L2,PLAU,SCD,SREBF1	 	
P3	 	DCN	-1.279	other	 	-1.334	 	-0.059	-1.160	2.43E-02	CTGF,DUSP1,FST,HIF1A,ITGAV,KIT,MMP9,THBS1,VCAM1	 	
P3	 	platelet activating factor	 	chemical - endogenous mammalian	 	0.906	bias	0.511	 	2.43E-02	EGR1,FOS,ITGB2,MMP14,MMP9,NR4A1,PAFAH1B2,PLAU,THBS1	 	
P3	 	vorinostat	 	chemical drug	 	-0.863	 	0.005	-0.883	2.43E-02	BCL2L1,BMF,CLDN2,CTSD,CYP1B1,DUSP1,ELOVL1,FAS,FIS1,GRN,HDAC2,HSPA5,KIT,MKI67,MLH1,MMP9,PTP4A3,SOCS3,TNFRSF1A,TOP2A,TXN	 	
P3	 	GSK3B	1.940	kinase	 	-0.933	 	-0.073	-0.684	2.45E-02	APP,BCL2L1,CDH11,DDIT3,EMD,FOS,HIF1A,KIF3B,MMP9,NFKBIZ,SH3GLB1,SPP1,SREBF1,TP63	 	
P3	 	SLC25A13	2.299	transporter	 	 	 	 	 	2.45E-02	ALPL,ANXA2,APP,ASNS,C6,CD63,FADS3,FAM129A,MMEL1,MTHFD1L,NQO1,PFKFB3,PSAT1,SERPINE2	 	
P3	 	mir-10	2.662	microrna	Inhibited	-2.156	bias	-0.499	-0.514	2.45E-02	ACVR1C,BCL2L1,BMF,CYR61,GAB2,HIF1A,HTATIP2,KLF4,MAF,MKNK2,PSMD8,SGPL1	 	
P3	 	DMD	-1.880	other	 	 	 	 	 	2.47E-02	ACTG1,APLP2,BTG2,DNAJC5,HSPB6,IP6K3,KCNMA1,LAMP2,LDB3,MYH1,NQO2,PPP1R3C,PROX1,SGCG,SGSH,SH3GLB1,SPTB,ST3GAL6,SYNM,TPM3,TTC7B,TTL	 	
P3	 	AZGP1	-2.480	transporter	 	-1.172	 	-0.169	-0.798	2.47E-02	BCL2L1,CEBPB,DSP,EGR1,GYS1	 	
P3	 	BHLHE40	1.214	transcription regulator	 	-1.322	bias	-0.262	-0.810	2.47E-02	BCL2L1,BHLHE41,MLH1,SREBF1,TP63	 	
P3	 	FUT8	-1.083	enzyme	Inhibited	-2.236	bias	-0.372	-1.404	2.47E-02	CYP1B1,GSTM3,GSTM5,NFE2L2,TFRC	 	
P3	 	mangiferin	 	chemical - endogenous non-mammalian	 	 	 	 	 	2.47E-02	BCL2L1,DGAT2,HMOX1,MMP9,NQO1	 	
P3	 	nickel	 	chemical toxicant	Activated	2.000	bias	0.486	1.028	2.47E-02	GAPDH,HIF1A,IL1RN,PLAT,UGCG	 	
P3	 	KLF2	-3.804	transcription regulator	 	-0.423	bias	-0.342	0.779	2.47E-02	ASS1,CCND3,CNP,CTGF,CYP1B1,HIF1A,JUNB,LGALS9,MMP14,NQO1,PLOD2,RALA,SOX9,SREBF1,TFPI,TFRC,TGFB2,THBS1,VCAM1	 	
P3	 	22(R)-hydroxycholesterol	 	chemical - endogenous mammalian	Activated	2.169	bias	0.376	1.201	2.49E-02	ABCB11,APOC1,APOE,APP,NR1H3,PLTP,SREBF1	 	
P3	 	CARM1	1.889	transcription regulator	 	1.982	bias	0.642	 	2.49E-02	ABCB11,FOS,FTH1,FTL,IGFBP4,PCK1,STC2	 	
P3	 	OGT	1.820	enzyme	 	-0.816	 	0.024	-0.876	2.49E-02	ACO2,BCL2L1,FOS,NDUFA6,NDUFA8,NDUFC2,OGDH	 	
P3	 	PLAUR	-2.061	transmembrane receptor	 	1.850	bias	0.495	0.562	2.49E-02	BCL2L1,CTSB,CYBB,ITGAV,MMP9,MT-CO1,PLAU	 	
P3	 	FOXO4	-1.407	transcription regulator	 	-0.914	bias	0.391	-1.919	2.50E-02	BCL2L1,CCND2,CTGF,HIF1A,HMGCS1,MMP9,SCD,SREBF2	 	
P3	 	SKIL	1.099	transcription regulator	Activated	2.157	bias	0.365	1.134	2.50E-02	ADAM12,CDH11,CDKN2AIPNL,CXCL12,KPNA1,SLC1A5,SOX17,VAT1	 	
P3	 	MYD88	1.531	other	 	1.634	bias	0.624	 	2.52E-02	ALDH1A2,ATP6V1E1,CD14,CD83,CXCL12,CYR61,DUSP1,EDNRB,EGR1,FOS,GDF15,HIF1A,HLA-A,HMOX1,HSP90AB1,HSPA5,IL1RN,LPAR1,MKI67,MMP14,MMP9,MSR1,NFKBIZ,SAA1,SLC7A2,SOCS3,SPP1,USP18,VCAM1	 	
P3	 	SIM1	2.701	transcription regulator	Activated	3.138	bias	0.683	 	2.53E-02	AKR1B1,AOX1,APOE,BAG6,EGR1,EIF5A,FCGR2A,FKBP3,GLUL,HLA-A,ICMT,IGFBP4,LAMA2,LCP1,LEP,LTF,MRPL37,MSC,MTPN,NAP1L4,NDUFA1,OAZ1,PEA15,PFN1,PLP1,TYROBP	 	
P3	 	Pka	 	complex	 	-1.253	bias	0.364	-2.670	2.57E-02	APOE,CCND3,CD14,CEBPB,CTGF,DDIT3,DUSP1,DUSP4,EGR1,FOS,HMOX1,JUNB,LEP,NR4A1,PCK1,PPP1R1B,SOX9,SREBF1	 	
P3	 	NRIP1	-2.028	transcription regulator	 	-0.563	bias	-0.408	0.585	2.57E-02	ACO2,AIFM2,CIDEA,COX7A1,CYP4B1,HADHB,OTUB2,PTX3,SCD,THRSP	 	
P3	 	SHH	-3.173	peptidase	 	1.876	bias	0.479	0.242	2.62E-02	ATF5,CCND2,CNBP,CTPS1,ERBB4,GPC1,HMGA1,IMPDH2,LASP1,LFNG,LMX1A,NR4A1,PLAT,PVR,SFRP1,SFRP2,SOX9,SPP1,SREBF1,SRM,TGFB2,UNG	 	
P3	 	bee venom	 	chemical - endogenous non-mammalian	 	-1.573	 	0.245	-2.262	2.65E-02	CYBB,DDIT3,FOSB,FYB,ITGAV,JUNB,KLF2,KLF4,LPIN2,MKI67,NUPR1,SLC7A11,SOCS3,TOP2A	 	
P3	 	NRAS	1.627	enzyme	 	 	 	 	 	2.68E-02	BCL2L1,CYBB,DUSP6,EGR1,ETV5,HIF1A,MKI67,MSR1,PLAU,PTP4A3,SESN3,SV2B,XPNPEP2	 	
P3	 	BCL2L1	1.780	other	 	-1.567	 	0.059	-1.742	2.72E-02	ALOX5AP,BCL2L1,CYCS,FAS,MMP9,NQO1,PTPRC,THBS1,TNFRSF1A	 	
P3	 	adenosine	 	chemical - endogenous mammalian	 	-0.785	 	0.058	-0.923	2.72E-02	AIFM2,BCL2L1,CD28,FOS,HIF1A,HMOX1,HSPA5,ITGB2,SOCS3	 	
P3	 	FGFR3	-3.063	kinase	 	 	 	 	 	2.78E-02	BCL2L1,DUSP6,FOS,MAF,PROX1,SPP1	 	
P3	 	bufalin	 	chemical reagent	 	-0.447	 	-0.237	0.082	2.78E-02	DDIT3,EGR1,FOS,HSPA5,RPLP0,YWHAG	 	
P3	 	methylnitronitrosoguanidine	 	chemical toxicant	 	0.377	bias	0.710	 	2.78E-02	BTG2,EGR1,FAS,GDF15,PLAT,PLAU	 	
P3	 	NR1I2	-3.631	ligand-dependent nuclear receptor	Activated	2.355	 	0.189	1.566	2.81E-02	ABCC3,AHCY,ALAS1,ALDH3A2,CES1,CES2,CYP4A11,ENTPD5,GLUL,GOT1,GSTM3,GSTM5,GSTP1,HMGCS1,LPCAT3,PGD,POR,SCD,SREBF1	 	
P3	 	vincristine	 	chemical drug	 	0.117	 	0.209	-0.298	2.83E-02	BCL2L1,EGR1,FAS,HNRNPK,HSP90AB1,LCP1,NCAM1,TUBB2A	 	
P3	 	sodium chloride	 	chemical - endogenous mammalian	 	1.378	bias	0.568	 	2.85E-02	ADRA2A,AKR1B1,CTGF,CYBB,FOS,HIF1A,HMOX1,SLC5A3,SOD1,SPP1	 	
P3	 	CUL4B	1.419	other	Inhibited	-2.449	bias	-0.426	-1.406	2.87E-02	HSPA9,IGFBP3,NME1,PYGO2,SOD1,TPM3,UBXN1	 	
P3	 	methimazole	 	chemical drug	 	0.757	bias	-0.276	1.418	2.87E-02	COL5A3,IGFBP3,IGFBP4,MT-CO1,PRDX1,SHC1,TPO	 	
P3	 	L-glutamic acid	 	chemical - endogenous mammalian	 	-1.196	bias	0.401	-2.588	2.87E-02	APP,BAG3,BCL2L1,CETN2,EGR1,FOS,FOSB,HEXA,JUNB,LEP,MAP1B,PLIN2,SORBS1,SORL1	 	
P3	 	FGF8	-5.454	growth factor	 	0.470	 	0.209	-0.271	2.91E-02	CMTM3,CYCS,ETV5,FGFR2,LMX1A,MKI67,PAX5,RPL26,SHC1,SLC27A3,SPP1,THBS1,TNXB	 	
P3	 	RARB	-1.307	ligand-dependent nuclear receptor	 	1.912	bias	0.463	0.695	2.93E-02	EGR1,FOLR2,GNB1,IGFBP3,ILF2,ITGAV,MAP2K3,RET,SPP1,SSR4,TCEA1,USP18	 	
P3	 	ATP2A2	1.521	transporter	 	-1.000	bias	-0.426	-0.148	2.95E-02	APP,DDIT3,DGAT2,SCD	 	
P3	 	CSF2RB	1.750	transmembrane receptor	 	-0.152	bias	0.601	 	2.95E-02	BCL2L1,CCND2,FOS,JUNB	 	
P3	 	DDR1	-2.948	kinase	 	1.982	 	0.237	1.513	2.95E-02	BCL2L1,MMP14,MMP9,VCAM1	 	
P3	 	Fgfr	 	group	 	1.000	bias	0.615	 	2.95E-02	BCL2L1,FOS,HMOX1,SPP1	 	
P3	 	Go6983	 	chemical - kinase inhibitor	 	1.067	bias	-0.426	1.912	2.95E-02	CTGF,FOS,PRDX1,PRKCE	 	
P3	 	KAT2A	1.232	enzyme	 	 	 	 	 	2.95E-02	CCND2,EDEM1,HSPA5,NR1H3	 	
P3	 	ROCK1	-1.036	kinase	 	0.927	bias	0.609	 	2.95E-02	APP,CCND2,CCND3,VCAM1	 	
P3	 	SPINT1	-3.809	other	 	1.000	bias	-0.710	 	2.95E-02	CLDN2,IGFBP4,PROX1,SOX17	 	
P3	 	STIM1	2.095	ion channel	 	 	 	 	 	2.95E-02	BCL2L1,HMOX1,NQO1,PRDX1	 	
P3	 	TNFSF9	-1.080	cytokine	 	0.849	bias	0.426	0.005	2.95E-02	BCL2L1,CD14,TNFRSF1A,VCAM1	 	
P3	 	SELENOS	-1.179	other	 	-1.154	bias	-0.710	 	2.95E-02	ADIPOQ,CEBPB,DDIT3,HSPA5	 	
P3	 	epoprostenol	 	chemical - endogenous mammalian	 	-0.371	 	0.203	-0.768	2.95E-02	EGR1,FOS,HIF1A,SPP1	 	
P3	 	epothilone B	 	chemical drug	 	-1.067	 	0.047	-1.161	2.95E-02	BTG2,FAS,THBS1,TOP2A	 	
P3	 	lactic acid	 	chemical - endogenous mammalian	 	0.000	 	0.237	-0.335	2.95E-02	BSG,PCK1,PCK2,SLC16A1	 	
P3	 	statin	 	chemical drug	 	-0.152	 	-0.164	0.172	2.95E-02	CYBB,LEP,SREBF2,TXNRD1	 	
P3	 	BAG1	1.170	other	 	1.400	bias	0.521	 	2.99E-02	BCL2L1,FKBP5,FOS,MAPT,PLAU	 	
P3	 	FGF4	 	growth factor	 	 	 	 	 	2.99E-02	FOS,HMGCS1,MMP14,SCD,SOX17	 	
P3	 	GADD45A	1.755	other	 	1.195	 	-0.129	1.479	2.99E-02	BCL2L1,FOSB,MMP9,TP63,UCHL1	 	
P3	 	H2AFX	2.249	transcription regulator	 	 	 	 	 	2.99E-02	ACTB,MLH1,RPL13,SFRP2,SLC7A11	 	
P3	 	KISS1	1.584	other	 	-1.292	bias	0.323	-1.999	2.99E-02	EGR1,FOS,GSTP1,MMP9,NFE2L1	 	
P3	 	MED13	1.286	transcription regulator	 	-0.447	bias	-0.710	 	2.99E-02	AACS,CIDEA,ENO1,THRSP,TKT	 	
P3	 	NFIX	1.227	transcription regulator	 	0.038	 	0.158	-0.270	2.99E-02	ADAM12,ALAS1,CHI3L1,PDGFA,SLC25A5	 	
P3	 	Sch-23390	 	chemical drug	 	0.984	bias	-0.568	 	2.99E-02	EGR1,FAS,FOS,FOSB,HSPA9	 	
P3	 	ceruletide	 	biologic drug	 	1.949	bias	0.497	0.980	2.99E-02	ACTG1,ATF4,DDIT3,HMOX1,HSPA5	 	
P3	 	miR-204-5p (and other miRNAs w/seed UCCCUUU)	 	mature microrna	Inhibited	-2.236	bias	-0.710	 	2.99E-02	ARPC1B,CDH11,EFNB1,MMP9,SHC1	 	
P3	 	p70 S6k	 	group	Activated	2.190	 	0.237	1.672	2.99E-02	CCND3,EEF1A1,PABPC4,SCD,SREBF1	 	
P3	 	glucagon	 	biologic drug	 	-0.281	bias	0.362	-1.365	3.03E-02	FOS,GNG12,LIMA1,NR4A1,PHLDB2,PPP1R1B,RMDN3,SREBF1,TNS1	 	
P3	 	Growth hormone	 	group	 	-1.908	bias	0.355	-3.294	3.04E-02	ADIPOQ,CCND2,CEBPB,EGR1,FKBP5,FOS,GDF15,GSTM5,IGFBP3,IGFBP6,MMP9,NR1D1,PCK1,PFKFB3,RPH3A,SOCS3,SPP1	 	
P3	 	NR1H3	1.886	ligand-dependent nuclear receptor	 	1.745	 	0.041	1.605	3.10E-02	ACSL3,APOE,ARL4C,CIDEA,IL1RN,MID1IP1,MMP9,NR1H3,NR5A2,PLTP,SCD,SREBF1,SREBF2,THRA	 	
P3	 	TP73	-3.682	transcription regulator	 	1.115	bias	0.259	-0.377	3.10E-02	ABCC1,ADAM17,BTG2,CCND3,CD83,COL5A2,COX4I1,CTSD,CYR61,DDIT3,EGR1,FAS,FST,GAB2,HSPB8,IGFBP3,IGFBP4,KIT,LCP1,LYZ,MLH1,MMP14,NCAM1,NUPR1,POLD2,PTP4A3,RRM2B,SERPINA1,SERPINE2,SPP1,THBS1,TNFRSF12A,TNFRSF1A,TPP1,TREM2,XRCC6,YWHAB	 	
P3	 	poly rI:rC-RNA	 	biologic drug	 	1.975	bias	0.523	 	3.12E-02	ACSL3,AFAP1,ANXA1,ATF4,CCND3,CD14,CD209,CD83,CEBPB,CNP,DUSP1,EGR1,FAS,FOS,GBP1,GDF15,HLA-A,HLA-G,IGFBP6,IL10RA,IRAK1,JUNB,KLF4,LGALS9,LTF,LY6E,LYZ,MMP9,MSR1,NR4A1,OAS1,PCK2,PI4KB,PLAU,PSMA3,PTPN23,RARRES3,SDC4,STAB1,STAM,THBS1,TNFAIP8L2,TOLLIP,TPO,UBQLN1,VCAM1	 	
P3	 	DICER1	1.105	enzyme	 	0.235	 	-0.167	0.876	3.12E-02	ACVR1C,CAMK2D,CCND2,CRYM,CYR61,EGR1,FOS,GNG2,LCP1,MAF,MMP9,MT-ND5,NANOS1,NR6A1,PANK3,PLAU,RAD23A,RET,SCN11A,SERPINA1,SLC4A4,SOCS3,THBS1	 	
P3	 	calphostin C	 	chemical - kinase inhibitor	 	-1.348	bias	-0.633	 	3.14E-02	BCL2L1,DUSP1,FOS,GFPT1,HSPA5,KIT,MMP9,MSR1,NQO1,PLAU	 	
P3	 	BMP6	-3.540	growth factor	 	1.117	bias	0.355	-0.001	3.16E-02	ADAMTS5,ALDH1A2,CTGF,CYP1B1,EPHX1,ETV5,HMOX1,KLF4,MATN2,SLC20A1,STS,TNFRSF12A,TXNRD1	 	
P3	 	arachidonic acid	 	chemical - endogenous mammalian	 	-1.008	 	0.165	-1.587	3.16E-02	CD83,EGR1,FAS,FOS,HMOX1,PLAU,PLTP,SCD,SREBF1,THRSP,TNFRSF1A,UCP2,VCAM1	 	
P3	 	phorbol esters	 	chemical - other	 	0.197	bias	0.517	 	3.16E-02	ANXA1,APP,DUSP1,EGR1,FGFR2,FOS,JUNB,MMP9,ODC1,PDGFA,PLAT,PLAU,TXN	 	
P3	 	4-(2-aminoethyl)benzenesulfonylfluoride	 	chemical - protease inhibitor	 	 	 	 	 	3.17E-02	DDIT3,HMOX1,HSPA5	 	
P3	 	AGRP	-4.227	other	 	 	 	 	 	3.17E-02	FOS,LEP,PSMA4	 	
P3	 	ALOX15B	-1.418	enzyme	 	 	 	 	 	3.17E-02	CBX3,KLF4,TP63	 	
P3	 	Agtr1b	 	g-protein coupled receptor	 	 	 	 	 	3.17E-02	CTGF,FOS,VCAM1	 	
P3	 	BCKDK	2.470	kinase	 	 	 	 	 	3.17E-02	BCKDK,MBP,PLP1	 	
P3	 	CD53	2.546	other	 	 	 	 	 	3.17E-02	BCL2L1,DHX32,TPPP3	 	
P3	 	Ccl6	 	cytokine	 	 	 	 	 	3.17E-02	CTSS,MMP9,SERPINA1	 	
P3	 	FBXO42	1.066	other	 	 	 	 	 	3.17E-02	CSF1,MMP9,VCAM1	 	
P3	 	FGF3	-2.964	growth factor	 	 	 	 	 	3.17E-02	MMP9,PLAT,PLAU	 	
P3	 	HTR7	-4.203	g-protein coupled receptor	 	 	 	 	 	3.17E-02	FOS,STAB1,THBS1	 	
P3	 	LOC102724428/SIK1	-3.597	kinase	 	 	 	 	 	3.17E-02	SCD,SREBF1,THRSP	 	
P3	 	MEMO1	1.466	other	 	 	 	 	 	3.17E-02	CTSD,FOS,STC2	 	
P3	 	N-chlorotaurine	 	chemical - kinase inhibitor	 	 	 	 	 	3.17E-02	HMOX1,PRDX1,TXN	 	
P3	 	Pde	 	group	 	 	 	 	 	3.17E-02	FOS,HMOX1,NR4A1	 	
P3	 	S100P	-1.684	other	 	 	 	 	 	3.17E-02	ACTB,CFL1,CTSD	 	
P3	 	aurothioglucose	 	chemical drug	 	 	 	 	 	3.17E-02	HMOX1,LEP,NQO1	 	
P3	 	betaine	 	chemical - endogenous mammalian	 	 	 	 	 	3.17E-02	DDIT3,HSPA5,SREBF1	 	
P3	 	cytochalasin B	 	chemical toxicant	 	 	 	 	 	3.17E-02	CD63,MCAM,MMP9	 	
P3	 	immune complex	 	complex	 	 	 	 	 	3.17E-02	IL1RN,SOCS3,VCAM1	 	
P3	 	miR-224-5p (miRNAs w/seed AAGUCAC)	 	mature microrna	 	 	 	 	 	3.17E-02	CD53,CXCL14,MMP9	 	
P3	 	racemic flurbiprofen	 	chemical drug	 	 	 	 	 	3.17E-02	APP,MMP9,THRSP	 	
P3	 	raltitrexed	 	chemical drug	 	 	 	 	 	3.17E-02	ANXA2,FAS,TMSB10/TMSB4X	 	
P3	 	Rock	 	group	 	-0.132	bias	0.304	-0.737	3.18E-02	APP,CDC42,CTGF,FOS,NOP16,SOX9,SPP1,VCAM1	 	
P3	 	chloroquine	 	chemical drug	Activated	2.027	 	-0.047	2.159	3.18E-02	APP,BCL2L1,CTSD,HIF1A,PRNP,SOCS3,SQSTM1,TXN	 	
P3	 	DNMT1	1.535	enzyme	 	 	 	 	 	3.19E-02	ACTB,CNR1,GSTP1,MLH1,NPC1L1,PYCARD,RPL13,SFRP2,SLC7A11,SOX17,XIST	 	
P3	 	TGFA	1.618	growth factor	 	0.748	bias	0.487	-0.843	3.19E-02	BCL2L1,CEBPB,CTGF,FOS,GJB2,GSTP1,IGFBP4,JUNB,MMP9,PLAT,PRNP,SERPINA1	 	
P3	 	ANXA1	3.035	enzyme	 	-1.220	 	-0.178	-0.835	3.24E-02	ANXA1,ANXA2,CSF1,FARSA,ITGB2,PLAU	 	
P3	 	GCK	-2.362	kinase	 	-0.277	 	-0.085	-0.088	3.24E-02	ATP5G1,CCND2,FH,PCK1,SCD,SREBF1	 	
P3	 	HSPA5	5.026	enzyme	 	0.211	 	-0.101	0.456	3.24E-02	APP,BCL2L1,DDIT3,HSPA5,HSPA8,SREBF1	 	
P3	 	MAPK14	1.352	kinase	 	0.059	bias	0.472	-2.065	3.26E-02	ATP5J2,CALR,CD83,DUSP1,FAS,FOS,HMOX1,JUNB,MMP9,PCK1,PLAU,PRDX1,PSMD10,SHC1,SOCS3,SOD1,SREBF1,SREBF2,STIM1,TOP2A,TRPA1	 	
P3	 	ESRRG	-3.401	ligand-dependent nuclear receptor	 	1.149	bias	0.552	 	3.27E-02	ALDOC,CYCS,ENO1,FGF1,GAPDH,PCK1,PKM	 	
P3	 	Hsp27	 	group	 	-1.000	 	0.069	-1.179	3.27E-02	CD14,CSF1,CSF1R,FOS,GBA,MAPT,PPP1R1B	 	
P3	 	carbamylcholine	 	chemical drug	 	-1.948	bias	0.365	-2.891	3.27E-02	APOE,APP,BTG2,EGR1,FOS,GEM,NR4A1	 	
P3	 	CXCL12	2.054	cytokine	 	-0.654	bias	0.426	-2.649	3.29E-02	AIF1,AKR1C3,ARPC4,BCL2L1,BMP6,CD3G,CXCL12,DAD1,EGR1,FAS,FLNA,FOS,JUNB,KIT,MAPK8IP2,MAPRE3,MMP14,MMP9,NR2F6,NR4A1,PLAU,SOCS3,ZBTB16	 	
P3	 	metribolone	 	chemical reagent	Activated	2.706	bias	0.400	0.822	3.29E-02	ACSL3,ACTN1,ADRM1,APP,BCL2L1,EGR1,EIF5,FKBP5,FOS,GDF15,GFPT1,MAF,MARS,MYL12B,NDUFV3,PHYH,PPIB,RAB4A,RAD23A,RGMA,SREBF1,SREBF2,STK39,THBS1	 	
P3	 	Rxr	 	group	 	0.991	 	0.160	0.676	3.34E-02	ABCB11,ALAS1,APOE,ITGB2,LEP,LTF,NR1H3,NR5A2,PCK1,PLIN2,PLTP,POR,SPP1,SREBF1	 	
P3	 	Ccl2	 	cytokine	 	1.463	bias	0.304	0.607	3.37E-02	ADIPOQ,CD14,CSF1,CTSB,KLF4,LEP,SDC4,TIE1,VCAM1	 	
P3	 	F2RL1	-1.860	g-protein coupled receptor	 	-0.547	bias	0.575	 	3.37E-02	CTGF,CTSD,CYR61,DUSP6,FAS,FOS,IRF8,MMP9,MSC	 	
P3	 	prostaglandin E2	 	chemical - endogenous mammalian	Activated	2.247	 	0.233	1.047	3.45E-02	ANXA2,APP,BCL2L1,CD14,CD83,CEBPB,CSF1,CTGF,CXCL12,DUSP1,DYNLL1,EGR1,FAS,FOS,FOSB,FST,FSTL3,HIF1A,HMOX1,IGFBP4,IL1RN,MMP14,MMP9,NR1H3,NR4A1,NR5A2,PLAU,SOCS3,ST6GALNAC2,THBS1,THRSP,UCP2,XRCC6	 	
P3	 	R5020	 	chemical reagent	 	-0.277	bias	0.441	-1.134	3.46E-02	BCL2L1,CEBPB,CTSD,DUSP4,FKBP5,HNRNPAB,HSD11B2,NAGA,SAA1,ZBTB16	 	
P3	 	CX3CL1	1.509	cytokine	 	1.342	bias	0.440	0.359	3.57E-02	BCL2L1,HIF1A,HMOX1,MMP9,MSR1	 	
P3	 	NFAT (complex)	 	complex	 	0.108	bias	0.552	 	3.57E-02	AIF1,CD68,CYGB,NR4A1,SPP1	 	
P3	 	NR2E1	-4.240	ligand-dependent nuclear receptor	 	 	 	 	 	3.57E-02	HRAS,MAP4K4,MAPK10,PLCE1,TGFB2	 	
P3	 	mir-193	 	microrna	 	-1.387	bias	-0.710	 	3.57E-02	CD151,KIT,MAPT,PLAU,SULF1	 	
P3	 	ADRA1B	-4.167	g-protein coupled receptor	 	1.000	 	0.164	0.672	3.57E-02	ADRA1A,CEBPB,DUSP1,EGR1,FOS,LEP,NR4A1,RALA	 	
P3	 	mir-182	-1.652	microrna	 	-1.188	bias	-0.589	 	3.57E-02	CDK6,LRP6,NCAM1,NFASC,SLC30A1,SLC39A1,SLC39A3,SQSTM1	 	
P3	 	TGFB2	6.389	growth factor	 	-0.134	 	0.246	-0.966	3.60E-02	CDH11,CTGF,DES,EGR1,FAS,FOS,HMOX1,ID4,MMP9,PLOD2,SCD,SPP1,TGFB2,THBS1	 	
P3	 	1-methyl-2-pyrrolidinone	 	chemical toxicant	 	 	 	 	 	3.60E-02	FOS,MMP9	 	
P3	 	AKR1C3	2.841	enzyme	 	 	 	 	 	3.60E-02	FKBP4,SIAH2	 	
P3	 	AP2A1	1.010	transporter	 	 	 	 	 	3.60E-02	APP,TALDO1	 	
P3	 	APLP2	1.738	other	 	 	 	 	 	3.60E-02	GSK3B,PRNP	 	
P3	 	ARID2	1.041	transcription regulator	 	 	 	 	 	3.60E-02	ALPL,FGFR2	 	
P3	 	ATF6B	-1.125	transcription regulator	 	 	 	 	 	3.60E-02	DDIT3,HSPA5	 	
P3	 	ATP8B1	-1.191	transporter	 	 	 	 	 	3.60E-02	ABCB11,CFTR	 	
P3	 	BBS12	-1.092	other	 	 	 	 	 	3.60E-02	ADIPOQ,LEP	 	
P3	 	BO-653	 	chemical drug	 	 	 	 	 	3.60E-02	PSMA3,PSMA4	 	
P3	 	CHRM4	-4.137	g-protein coupled receptor	 	 	 	 	 	3.60E-02	EGR1,ITGAV	 	
P3	 	DNM1	-1.206	enzyme	 	 	 	 	 	3.60E-02	APP,SLC24A2	 	
P3	 	FBXL5	1.363	enzyme	 	 	 	 	 	3.60E-02	FTH1,TFRC	 	
P3	 	GCLC	1.194	enzyme	 	 	 	 	 	3.60E-02	FOS,JUNB	 	
P3	 	GJB6	-1.247	transporter	 	 	 	 	 	3.60E-02	GJB2,MBP	 	
P3	 	GNRH2	-1.168	other	 	 	 	 	 	3.60E-02	RPLP1,RPSA	 	
P3	 	HCAR1	-1.415	g-protein coupled receptor	 	 	 	 	 	3.60E-02	BSG,SLC16A1	 	
P3	 	HDAC10	-1.580	transcription regulator	 	 	 	 	 	3.60E-02	MMP9,SQSTM1	 	
P3	 	MIR129	 	group	 	 	 	 	 	3.60E-02	CDK6,PRKCE	 	
P3	 	NDST2	1.325	enzyme	 	 	 	 	 	3.60E-02	CMA1,CPA3	 	
P3	 	NUDT2	-1.033	phosphatase	 	 	 	 	 	3.60E-02	KIT,TPSAB1/TPSB2	 	
P3	 	PD 180970	 	chemical - kinase inhibitor	 	 	 	 	 	3.60E-02	BCL2L1,CCND2	 	
P3	 	Pld	 	group	 	 	 	 	 	3.60E-02	HIF1A,PTP4A3	 	
P3	 	RPRD1A	1.715	other	 	 	 	 	 	3.60E-02	CTSB,MMP9	 	
P3	 	Rsk	 	group	 	 	 	 	 	3.60E-02	ATF4,CEBPB	 	
P3	 	S3I-1757	 	chemical reagent	 	 	 	 	 	3.60E-02	BCL2L1,MMP9	 	
P3	 	SLC37A4	1.101	transporter	 	 	 	 	 	3.60E-02	DDIT3,HSPA5	 	
P3	 	SSFA2	-1.117	other	 	 	 	 	 	3.60E-02	ADIPOQ,LEP	 	
P3	 	STEAP4	-1.560	enzyme	 	 	 	 	 	3.60E-02	LEP,TP63	 	
P3	 	Stat dimer	 	complex	 	 	 	 	 	3.60E-02	BCL2L1,FOS	 	
P3	 	TBPL1	1.096	transcription regulator	 	 	 	 	 	3.60E-02	FOS,TP63	 	
P3	 	TIMP4	1.319	other	 	 	 	 	 	3.60E-02	BCL2L1,MMP14	 	
P3	 	TMSB10/TMSB4X	1.896	other	 	 	 	 	 	3.60E-02	FAS,TMSB10/TMSB4X	 	
P3	 	TRHR	-11.397	g-protein coupled receptor	 	 	 	 	 	3.60E-02	LEP,SOCS3	 	
P3	 	USE1	1.008	other	 	 	 	 	 	3.60E-02	DDIT3,HSPA5	 	
P3	 	VLDL	 	complex	 	 	 	 	 	3.60E-02	PLIN2,VCAM1	 	
P3	 	bafilomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.60E-02	HIF1A,SQSTM1	 	
P3	 	carboxyamido-triazole	 	chemical drug	 	 	 	 	 	3.60E-02	BAG3,FOS	 	
P3	 	durapatite	 	chemical - endogenous mammalian	 	 	 	 	 	3.60E-02	ALPL,SPP1	 	
P3	 	griseofulvin	 	chemical drug	 	 	 	 	 	3.60E-02	ALAS1,HMOX1	 	
P3	 	opioid	 	chemical drug	 	 	 	 	 	3.60E-02	HMOX1,PLAU	 	
P3	 	parbendazole	 	chemical reagent	 	 	 	 	 	3.60E-02	ALPL,SPP1	 	
P3	 	protocatechuic acid	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.60E-02	APP,SHC1	 	
P3	 	rubitecan	 	chemical drug	 	 	 	 	 	3.60E-02	FAS,PEBP1	 	
P3	 	sGC	 	complex	 	 	 	 	 	3.60E-02	EGR1,FOS	 	
P3	 	sertindole	 	chemical drug	 	 	 	 	 	3.60E-02	ACTB,APP	 	
P3	 	succinylacetone	 	chemical - endogenous mammalian	 	 	 	 	 	3.60E-02	ALAS1,CYBB	 	
P3	 	14,15-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.732	 	0.142	-1.978	3.69E-02	ADIPOQ,MMP9,NME1,PLAT	 	
P3	 	CYP2J2	-37.833	enzyme	 	-0.254	 	0.237	-0.716	3.69E-02	BCL2L1,MMP9,NME1,VCAM1	 	
P3	 	Ren2	 	peptidase	 	 	 	 	 	3.69E-02	CYBB,CYCS,MT-CO1,SPP1	 	
P3	 	acadesine	 	chemical drug	 	 	 	 	 	3.69E-02	DUSP4,EGR1,SREBF1,THRSP	 	
P3	 	cyclopiazonic acid	 	chemical - endogenous non-mammalian	 	0.061	bias	0.444	-0.826	3.69E-02	DDIT3,EGR1,FAS,FOS	 	
P3	 	ethidium	 	chemical toxicant	 	 	 	 	 	3.69E-02	CCND3,CTGF,CYR61,PLAU	 	
P3	 	mir-103	-1.652	microrna	 	-1.944	bias	-0.710	 	3.69E-02	CDK6,FBXW11,GRN,HIF1A	 	
P3	 	pilocarpine	 	chemical drug	 	 	 	 	 	3.69E-02	APP,FOS,FOSB,JUNB	 	
P3	 	plumbagin	 	chemical toxicant	 	-1.067	 	-0.142	-0.786	3.69E-02	BCL2L1,CYBB,GSK3B,PRKCE	 	
P3	 	reserpine	 	chemical drug	 	-0.958	bias	0.621	 	3.69E-02	ADRA2A,CNR1,EGR1,FOS	 	
P3	 	ethionine	 	chemical toxicant	Activated	2.646	bias	0.528	 	3.72E-02	ANXA1,CD14,PSMB10,S100A11,SPP1,TMSB10/TMSB4X,TNFRSF12A	 	
P3	 	histone deacetylase	 	complex	 	1.633	bias	-0.379	2.561	3.72E-02	CYR61,JUNB,KEAP1,MMP9,PLAT,PLAU,THBS1	 	
P3	 	PDGFB	1.415	growth factor	 	0.000	bias	0.362	-1.001	3.73E-02	EGR1,FGF1,FOS,IL1RN,KLF2,MMP9,NR4A1,SPP1,THBS1	 	
P3	 	PRKCB	1.920	kinase	 	0.871	bias	0.438	-0.274	3.73E-02	APP,BCL2L1,CD83,CLCN7,CYCS,EGR1,FOS,MMP9,SREBF1	 	
P3	 	4-tert-octylphenol	 	chemical toxicant	 	-0.816	bias	0.568	 	3.75E-02	ADIPOQ,CLSTN2,EMP1,ESR2,IGSF6,RPN2	 	
P3	 	ALDH1A2	-2.656	enzyme	 	-0.816	bias	-0.252	-0.199	3.75E-02	CSF1,CTGF,CYR61,IGFBP4,KIT,SPP1	 	
P3	 	ELANE	2.404	peptidase	 	0.447	bias	0.331	-0.294	3.75E-02	CD14,CTSB,FOS,HSPA5,MMP9,SERPINA1	 	
P3	 	isobutylmethylxanthine	 	chemical toxicant	 	1.913	bias	0.358	0.591	3.76E-02	ACSL3,ADIPOQ,CD14,CEBPB,EGR1,FOS,GAPDH,ITGB2,JUNB,NR1H3,PLAT,PLIN1,PLIN2,RAB5C,RAB7A,SCD,SREBF1,TUBB	 	
P3	 	chenodeoxycholic acid	 	chemical - endogenous mammalian	 	0.767	 	0.184	0.170	3.77E-02	ABCB11,ABCC3,APOB,APOE,CYP27A1,EGR1,MMP9,NR5A2,PCK1,PCK2,PLTP,TXNRD1	 	
P3	 	JUND	-1.240	transcription regulator	 	-0.128	bias	0.331	-0.934	3.80E-02	ALAS1,COL6A1,CSTA,CYBB,FTH1,HMOX1,MMP9,NR4A1,PLAU,SPP1	 	
P3	 	lipoteichoic acid	 	chemical - endogenous non-mammalian	Activated	2.654	bias	0.588	 	3.80E-02	BCL2L1,CD14,CD83,CYBB,HIF1A,HMOX1,IL1RN,MMP9,NR4A1,TOLLIP	 	
P3	 	IRAK4	-1.273	kinase	 	 	 	 	 	3.81E-02	APP,BTG2,CSRNP1,CXCL16,DAB2,EGR1,FOS,FOSB,GEM,NFKBIZ,NR4A1	 	
P3	 	isotretinoin	 	biologic drug	 	0.686	bias	0.490	-0.911	3.81E-02	BCL2L1,CYP1B1,CYP2B7P,IGFBP3,MMP9,OAS1,ODC1,PSMB10,RARRES3,TFRC,VCAM1	 	
P3	 	S100A9	-4.747	other	 	-0.229	 	0.206	-1.125	3.84E-02	ADAMTS5,ALPL,BMF,C1QB,CLEC9A,CPM,CXCL14,ETV5,FAS,FCGR2A,GJB2,KCNMA1,MYH1,NTRK3,PLAU,RAB20,SCUBE1,SEMA3B,USP18,VCAM1	 	
P3	 	pioglitazone	 	chemical drug	 	-0.484	 	0.081	-0.827	3.84E-02	ADIPOQ,APOB,APOE,APP,COX4I1,CTGF,EGR1,FOS,HMOX1,IL1RN,KLF4,LEP,MMP9,NR4A1,PFKL,PLIN1,PLIN2,SREBF1,TNFRSF1A,UCP2	 	
P3	 	celecoxib	 	chemical drug	 	0.970	 	-0.171	1.549	3.85E-02	APP,ATF4,BCL2L1,CD68,CIDEA,DDIT3,DES,FAS,GDF15,HMOX1,HSPA5,MKI67,MMP9,SLC25A6,TP63,VCAM1	 	
P3	 	nitroprusside	 	chemical drug	 	-0.698	 	0.123	-1.043	3.99E-02	ACTN1,DUSP6,EGR1,FAS,FOS,HMOX1,HSD11B2,SLC1A4	 	
P3	 	omeprazole	 	chemical drug	 	 	 	 	 	3.99E-02	ABCC3,BCL2L1,CTGF,CXCL12,EGR1,FOS,FST,POR	 	
P3	 	ID2	1.172	transcription regulator	 	0.832	 	-0.081	1.123	4.07E-02	BCL2L1,CCND2,CD83,CEBPB,CSF1,DUSP1,DUSP10,DUSP4,FCER1G,G6PC3,HIF1A,IL10RA,IL20RB,IRF8,LMO4,MAF,NR4A1,SOCS3,TNFRSF1A,TRAF3,ZBTB16	 	
P3	 	EFNA2	-6.009	kinase	 	-0.333	 	0.055	-0.497	4.12E-02	CTGF,DUSP4,DUSP6,ETV5,PLAT,SLC20A1,SOX9,TRIM2,USP9Y	 	
P3	 	cholic acid	 	chemical - endogenous mammalian	 	1.617	 	0.142	1.161	4.14E-02	ABCB11,ABCC3,CYP27A1,CYP4A11,EPHX1,NR1H3,PCK1,PLTP,RAD23B,SREBF1,SREBF2	 	
P3	 	INHA	-3.053	growth factor	 	-1.657	 	-0.014	-1.604	4.16E-02	CCND2,COL6A1,CTGF,CYP1B1,CYR61,DHX32,EPHX1,FST,IGFBP4,KIT,MATN2,MYL9,PCDH7,PTX3	 	
P3	 	dopamine	 	chemical - endogenous mammalian	 	0.043	 	0.086	-0.248	4.16E-02	BCL2L1,CLCN3,CNR1,DDIT3,EGR1,FOS,FST,GABBR1,GPC3,HMOX1,KCNK2,PPP1R1B,PPP1R2,TMEM205	 	
P3	 	linoleic acid	 	chemical - endogenous mammalian	 	0.447	 	0.237	-0.294	4.17E-02	APOB,APP,DDIT3,DUSP1,HSPA5,PLIN2,PLIN5,SCD,UCP2,VCAM1	 	
P3	 	ATF1	1.363	transcription regulator	 	-0.152	bias	0.355	-0.856	4.20E-02	CEBPB,EGR1,FOS,FTH1,HLA-G,HMOX1,THBS1	 	
P3	 	IRS2	-1.656	enzyme	 	0.459	 	0.149	0.085	4.20E-02	EGR1,FOS,LEP,PCK1,SREBF1,SREBF2,THRSP	 	
P3	 	LG100268	 	chemical reagent	 	1.071	 	0.237	0.460	4.20E-02	ABCB11,APOE,BCL2L1,NR1H3,PLIN2,SCD,SREBF1	 	
P3	 	RUVBL1	2.033	transcription regulator	Activated	2.449	bias	0.710	 	4.20E-02	CARS,CCND2,ERGIC1,HIST1H2BK,IGFBP3,METTL23,SESN2	 	
P3	 	SQSTM1	3.539	transcription regulator	 	1.412	bias	0.326	0.709	4.20E-02	EGLN3,GSTM5,KEAP1,LEP,NQO1,PLAT,RILPL1	 	
P3	 	valsartan	 	chemical drug	 	-1.080	bias	-0.411	-0.106	4.20E-02	ADIPOQ,APP,CYBB,FOS,KIT,LEP,SPP1	 	
P3	 	CLDN6	2.046	other	 	 	 	 	 	4.21E-02	ATF4,CLDN5,EIF2S1,HSPA5,KLF4	 	
P3	 	COMMD1	1.258	transporter	 	-0.447	bias	-0.710	 	4.21E-02	ALDOA,EGLN3,PFKFB3,STC2,TFRC	 	
P3	 	DPP4	-2.019	peptidase	 	-0.577	 	0.034	-0.652	4.21E-02	IL1RN,MMP14,PLAU,SREBF1,TOP2A	 	
P3	 	DRAP1	1.672	transcription regulator	 	 	 	 	 	4.21E-02	GAPDH,ILF2,RPL7A,RPLP0,SOD1	 	
P3	 	Ni2+	 	chemical reagent	Activated	2.207	bias	0.710	 	4.21E-02	ASNS,CSF1,HIF1A,PTGES2,VCAM1	 	
P3	 	TRPV4	-1.871	ion channel	 	-0.555	bias	0.592	 	4.21E-02	FAS,FOS,SOCS3,THBS1,VCAM1	 	
P3	 	deoxycorticosterone acetate	 	chemical drug	Activated	2.176	bias	0.355	1.403	4.21E-02	CD68,CYP4A11,SLC9A1,SPP1,VCAM1	 	
P3	 	tripterine	 	chemical - endogenous non-mammalian	 	1.287	 	0.059	1.156	4.21E-02	BAG3,GBA,HSPH1,TCP1,VCAM1	 	
P3	 	2-amino-5-phosphonovaleric acid	 	chemical - other	Activated	2.465	 	0.096	2.065	4.24E-02	AAGAB,ANLN,ATF4,BTG3,DCLK2,DUSP1,DUSP6,EGR1,FOS,FOSB,JUNB,LHFPL2,MED20,MLST8,NPY1R,NR4A1,SPRY4,ZNF605	 	
P3	 	Tnf (family)	 	group	 	1.065	bias	0.378	-0.329	4.24E-02	ABCC3,ADAMTS5,ADIPOQ,BCL2L1,C3AR1,CD4,CLDN2,CSF1,CXCL12,FST,HIF1A,LGALS9,MMP9,SAA1,SOCS3,TACR1,TYMP,VCAM1	 	
P3	 	ATP7A	1.474	transporter	 	 	 	 	 	4.26E-02	ADCYAP1,APP,PLP1	 	
P3	 	Atrial Natriuretic Peptide	 	group	 	 	 	 	 	4.26E-02	ADIPOQ,CTGF,LEP	 	
P3	 	BCAR1	1.545	enzyme	 	 	 	 	 	4.26E-02	EGR1,NAB2,RALA	 	
P3	 	CA074-methyl ester	 	chemical reagent	 	 	 	 	 	4.26E-02	APP,CTSB,LAMP2	 	
P3	 	CMKLR1	1.906	g-protein coupled receptor	 	 	 	 	 	4.26E-02	ADIPOQ,CCND2,PLIN1	 	
P3	 	CNGA3	-8.597	ion channel	 	 	 	 	 	4.26E-02	CAPN2,DDIT3,HSPA5	 	
P3	 	COPS8	2.230	other	 	 	 	 	 	4.26E-02	CCND2,CCND3,CDK6	 	
P3	 	CREB3L2	1.369	transcription regulator	 	 	 	 	 	4.26E-02	ATF5,HSPA5,SEC23B	 	
P3	 	FRMD6	1.076	other	 	 	 	 	 	4.26E-02	CTGF,FGF1,IGFBP3	 	
P3	 	FTH1	3.798	enzyme	 	 	 	 	 	4.26E-02	FTH1,FTL,TFRC	 	
P3	 	HOXB5	3.013	transcription regulator	 	 	 	 	 	4.26E-02	ITGAV,PLAU,RET	 	
P3	 	ITGA4	1.696	transmembrane receptor	 	 	 	 	 	4.26E-02	IL1RN,ITGAV,MMP9	 	
P3	 	LDB1	1.430	transcription regulator	 	 	 	 	 	4.26E-02	KIT,SFRP1,SFRP2	 	
P3	 	MTF1	1.403	transcription regulator	 	 	 	 	 	4.26E-02	ADAMTS5,MMP9,SLC30A1	 	
P3	 	MXD1	1.840	transcription regulator	 	 	 	 	 	4.26E-02	CCND2,EIF4A1,ODC1	 	
P3	 	PIAS3	1.227	transcription regulator	 	 	 	 	 	4.26E-02	BCL2L1,FTH1,TPSAB1/TPSB2	 	
P3	 	PRKRA	1.390	other	 	 	 	 	 	4.26E-02	MAF,RET,THBS1	 	
P3	 	RPS6KA3	1.100	kinase	 	 	 	 	 	4.26E-02	FOS,FSCN1,LEP	 	
P3	 	RPS6KA4	1.182	kinase	 	 	 	 	 	4.26E-02	DUSP1,FOS,JUNB	 	
P3	 	SGPL1	2.051	enzyme	 	 	 	 	 	4.26E-02	ABCC1,APP,BCL2L1	 	
P3	 	Trolox C	 	chemical drug	 	 	 	 	 	4.26E-02	HIF1A,MMP9,UCP2	 	
P3	 	edaravone	 	chemical drug	 	 	 	 	 	4.26E-02	DDIT3,FAS,HSPA5	 	
P3	 	lidocaine	 	chemical drug	 	 	 	 	 	4.26E-02	APP,BCL2L1,FOS	 	
P3	 	mesalamine	 	chemical drug	 	 	 	 	 	4.26E-02	HMOX1,ODC1,TPM3	 	
P3	 	scopolamine	 	chemical drug	 	 	 	 	 	4.26E-02	FOS,MAPT,MMP9	 	
P3	 	MAPK8	-1.218	kinase	 	1.027	bias	0.350	-0.477	4.27E-02	APOE,BCL2L1,CEBPB,CSTA,CXCL16,CYBB,CYP27A1,DUSP1,DUSP4,EGR1,FOS,FTH1,HMOX1,MMP9,MSR1,NUPR1,PLAU,PTX3,TACR1	 	
P3	 	FLT3	-1.767	kinase	 	 	 	 	 	4.31E-02	BCL2L1,CCND2,CCND3,CEBPB,CYBB,LYZ	 	
P3	 	rosuvastatin	 	chemical drug	 	1.408	 	0.133	1.085	4.31E-02	CYBB,HMGCS1,HMOX1,KIT,MVD,PMVK	 	
P3	 	SMAD7	-1.179	transcription regulator	 	-0.750	 	-0.233	0.137	4.38E-02	BZW2,COL6A1,CTGF,FAS,FST,FSTL3,HMOX1,MATN2,MMP9,NID2,PLAT,SCD,SOX9,TGFB2,TPM3,TXN	 	
P3	 	imatinib	 	chemical drug	 	-1.748	 	-0.139	-1.302	4.41E-02	APP,BCL2L1,BIRC7,CCND2,CEBPB,CXCL12,CYBB,DAB2,HMOX1,KIT,PLIN2,PRNP	 	
P3	 	DETA-NONOate	 	chemical reagent	 	-0.340	 	0.159	-0.781	4.44E-02	BCL2L1,DUSP1,FAS,FOS,HIF1A,HMOX1,MMP9,VCAM1	 	
P3	 	PTK2	-1.132	kinase	 	0.539	bias	0.372	-0.427	4.44E-02	CSPG4,CYR61,DSP,FOS,MMP9,P4HA1,THBS1,VCAM1	 	
P3	 	CD24	 	other	 	0.818	bias	0.710	 	4.45E-02	CFTR,CHAC1,FOS,GDF15,HS2ST1,HSPB8,MCAM,PLAU,SLC30A1,SLC4A4,TFPI,THBS1,TOP2A,TRIM2	 	
P3	 	PPARD	1.681	ligand-dependent nuclear receptor	 	0.452	bias	0.343	-1.018	4.50E-02	ALDH3A2,APOB,APOE,BCL2L1,C1QA,C1QB,C1QC,CCND2,CD68,CEBPB,LPIN2,MMP9,MPEG1,NPC1L1,PLIN2,PLP1,RABL6,SCD,SERINC2,THBS1,TNFRSF12A,UCP2	 	
P3	 	tetracycline	 	chemical drug	 	1.929	 	0.154	1.443	4.50E-02	CSF1,CTGF,HSPD1,ME1,PCDH18,PPP1R3C,SLC1A4,SPTLC3,STAM,TTC1,VDAC1	 	
P3	 	7-nitroindazole	 	chemical reagent	 	1.131	bias	-0.284	1.694	4.52E-02	FOS,FOSB,GSTP1,NCAM1	 	
P3	 	ITCH	1.208	enzyme	Activated	2.000	bias	-0.710	 	4.52E-02	CTGF,CYR61,FOS,TP63	 	
P3	 	batimastat	 	chemical - protease inhibitor	 	-0.577	 	0.089	-0.731	4.52E-02	CEBPB,MMP14,MMP9,SDC4	 	
P3	 	calcipotriene	 	chemical drug	 	0.132	 	0.209	-0.282	4.52E-02	FOS,JUNB,PLAU,SPP1	 	
P3	 	ellagic acid	 	chemical - endogenous non-mammalian	 	0.000	bias	-0.266	0.533	4.52E-02	AKR1B1,CDK6,HMOX1,NQO1	 	
P3	 	ethoxyquin	 	chemical toxicant	 	1.934	bias	0.627	 	4.52E-02	GSTM5,GSTP1,NQO1,PSMB5	 	
P3	 	miR-103-3p (and other miRNAs w/seed GCAGCAU)	 	mature microrna	 	-1.926	bias	-0.710	 	4.52E-02	CDK6,FBXW11,GRN,PLAG1	 	
P3	 	peroxynitrite	 	chemical toxicant	 	-0.152	bias	0.355	-0.856	4.52E-02	DDIT3,FOS,LMO4,MARCKSL1	 	
P3	 	Pdgf (complex)	 	complex	 	-0.421	bias	0.426	-1.852	4.61E-02	CCND2,CDK6,EGR1,EIF2S1,FOS,FOSB,HIF1A,HMOX1,JUNB,NCAM1,ODC1,PLAU,VCAM1	 	
P3	 	TXN	3.635	enzyme	 	0.891	 	0.151	0.531	4.72E-02	CCND2,CYP1B1,FOS,HIF1A,HMOX1,MMP9,TXN	 	
P3	 	ATN1	1.528	transcription regulator	 	 	 	 	 	4.72E-02	BTG3,CDH11,CDK2AP1,CNR1,FGF1,IL11RA,MARCKSL1,MCAM,NAB2,NR2F1,PABPC4,PPP2R1A,PSME1,SPP1,THRA,THRSP,TUBB	 	
P3	 	HIST1H1T	-1.733	other	 	1.155	bias	0.429	-0.333	4.76E-02	ARPC5,CCDC58,FKBP4,FOS,GLUL,HSPA4,MARS,OGT,PCCB,PHB2,RILPL1,SGF29	 	
P3	 	Hist1h1a	 	other	 	1.155	bias	0.429	-0.333	4.76E-02	ARPC5,CCDC58,FKBP4,FOS,GLUL,HSPA4,MARS,OGT,PCCB,PHB2,RILPL1,SGF29	 	
P3	 	ITGB1	-1.024	transmembrane receptor	 	1.093	 	0.225	0.329	4.76E-02	ABCC1,APOE,FLNA,FOS,IL1RN,ITGAV,JUNB,LIMS1,LRP6,MMP9,PLAU,THBS1	 	
P3	 	MAX	1.626	transcription regulator	 	-1.980	 	-0.160	-1.662	4.76E-02	CBX5,CCND2,CYCS,DDIT3,DKC1,FTH1,HDAC2,HMGA1,LAMP2,NPM1,ODC1,RBBP8	 	
P3	 	IGF2	1.214	growth factor	 	0.976	bias	0.254	0.320	4.77E-02	ARHGDIA,ARHGEF2,CTGF,CYP1B1,DDIT3,DUSP1,EGR1,GNB1,GRN,HIF1A,IGFBP3,IGFBP4,IGFBP6,JUNB,LEP,SLC20A1,SLC30A1,SOCS3,SPP1,THRA	 	
P3	 	SOX11	-3.266	transcription regulator	 	-0.543	bias	0.299	-1.518	4.88E-02	ADAM9,CD52,EGR1,FAM45A,FAS,HSPD1,LGALS9,PAG1,PAX5,PDGFA,YPEL1	 	
P3	 	TET2	1.079	other	Activated	2.840	bias	0.434	1.160	4.88E-02	AFF3,ANXA2,CHST11,FAM129A,HS6ST1,ITGB2,KLF2,PXDC1,SH2B3,SLC20A1,SLC6A8,SORL1,TRIOBP,XYLT1,ZBTB16	 	
P3	 	HLX	1.428	transcription regulator	 	0.128	bias	-0.311	0.884	4.91E-02	CTSS,CYP1B1,EGR1,GDF15,PLXNA1,UNC5B	 	
P3	 	HSD11B1	1.583	enzyme	 	1.067	 	-0.118	1.302	4.91E-02	ADIPOQ,CPA3,LEP,NR1H3,SREBF1,UCP2	 	
P3	 	SSRP1	1.240	other	 	 	 	 	 	4.91E-02	EGR1,HNRNPK,LMOD2,MT-TY,PDGFA,PLAU	 	
P3	 	SU6656	 	chemical toxicant	 	0.555	bias	-0.710	 	4.91E-02	CSF1,CTGF,DDIT3,EGR1,JUNB,SOCS3	 	
P3	 	TERC	 	other	 	 	 	 	 	4.91E-02	CYP4A11,EGR1,H1F0,NR1D1,THRA,TUBB2A	 	
P3	 	andrographolide	 	chemical drug	 	-0.109	 	-0.101	0.135	4.91E-02	BCL2L1,CNR1,GSTP1,HMOX1,MMP9,VCAM1	 	
P3	 	cyclopamine	 	chemical reagent	 	-0.140	bias	-0.298	0.569	4.91E-02	CD14,FAS,MKI67,SMPD3,SOX9,SPP1	 	
P3	 	3-methylcholanthrene	 	chemical toxicant	 	1.570	bias	0.601	 	4.92E-02	CYP1B1,CYR61,FOS,GSTM5,ME1,NQO1,NR4A1,POR	 	
P3	 	IL11	-2.212	cytokine	 	-0.565	 	0.142	-0.933	4.92E-02	ANXA2,BCL2L1,F8,FOS,JUNB,SOCS3,SPP1,VCAM1	 	
P3	 	GAS6	1.243	growth factor	 	0.314	 	-0.028	0.377	4.92E-02	BCL2L1,CD68,CYR61,MSR1,SOCS3	 	
P3	 	NCOR-LXR-Oxysterol-RXR-9 cis RA	 	complex	Activated	2.236	bias	0.540	 	4.92E-02	APOC1,APOE,PLTP,SCD,SREBF1	 	
P3	 	SUPT16H	1.270	transcription regulator	 	 	 	 	 	4.92E-02	EGR1,HNRNPK,LMOD2,PDGFA,PLAU	 	
P3	 	alpha-tocopherol	 	chemical drug	 	-0.625	bias	-0.426	0.307	4.92E-02	ADIPOQ,CTGF,HMOX1,LEP,SQSTM1	 	
P3	 	imipramine	 	chemical drug	 	1.414	bias	0.372	0.888	4.92E-02	EGR1,FNDC4,FOS,TACR1,TSPO	 	
P3	 	oltipraz	 	chemical drug	Activated	2.172	bias	0.653	 	4.92E-02	ABCC3,FTH1,GSTM5,GSTP1,NQO1	 	
P3	 	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	 	chemical toxicant	 	-0.285	bias	0.300	-1.169	4.96E-02	APP,CNR1,CYBB,EGR1,FOS,FOSB,NR4A1,PARK7,PTPRC,TNFRSF1A	 	
P3	 	MYOD1	-6.732	transcription regulator	 	0.822	bias	0.397	-0.921	4.97E-02	ALDOA,ASS1,BCL2L1,BIN1,CBX5,CCND3,DES,DUSP1,GYS1,HSPB8,JUNB,KIFC3,LDB3,MKI67,MSC,PDGFA,PRKACA,RPL7A,SH3GLB1,STAM,TKT,TNS1	 	
P3	 	SGK1	-1.282	kinase	 	1.066	bias	0.518	 	4.98E-02	CDK6,CFTR,CTGF,SLC1A5,SLC38A3,SLC3A2,SLC5A3,SLC6A8,STIM1	 	
P3	 	USF2	1.395	transcription regulator	 	0.779	bias	0.637	 	4.98E-02	CFTR,CHI3L1,HMOX1,IGFBP3,P4HA1,SPP1,THBS1,THRSP,UCP2	 	
P3	 	methylphenidate	 	chemical drug	 	-1.961	 	0.237	-2.425	5.45E-02	EGR1,FOS,FOSB,NCAM1	 	
P3	 	NR4A3	-2.492	ligand-dependent nuclear receptor	 	-1.838	 	0.216	-2.476	5.46E-02	AASS,CCND2,COL16A1,COL6A1,HIF1A,MT-CO1,MYH1,NQO1,UCP2	 	
P3	 	DUSP1	-2.386	phosphatase	 	-1.929	 	-0.212	-1.262	6.14E-02	AACS,CIDEA,CYBB,DUSP1,IL1RN,LTF,MYH1,PDGFA,PLIN2,TGFB2,VCAM1	 	
P3	 	(+)-MK-801	 	chemical drug	Activated	2.045	 	0.125	1.678	6.84E-02	ALDOA,APP,EGR1,FOS,FOSB,HSPA5,INPP4B,JUNB,NPTXR,STXBP1	 	
P3	 	SIAH2	2.549	transcription regulator	Activated	2.208	 	0.194	1.780	7.45E-02	AKR1C3,EGLN3,FGF1,HIF1A,SIAH2	 	
P3	 	EZR	1.364	other	 	1.964	 	0.125	1.718	7.58E-02	BCL2L1,FAS,MMP14,MMP9	 	
P3	 	glutathione	 	chemical - endogenous mammalian	Inhibited	-2.630	 	-0.142	-2.256	7.82E-02	ABCC1,ASS1,DDIT3,GNL3,HIF1A,HMOX1,SLC7A11,VCAM1	 	
P3	 	RHO	-6.697	g-protein coupled receptor	Inhibited	-2.121	 	0.101	-2.408	9.22E-02	APP,C1QA,CEBPB,CSF1R,CTSS,FOS,GNB1,NCAM1	 	
P3	 	PRMT5	2.267	enzyme	Inhibited	-2.165	 	0.085	-2.350	1.06E-01	ADIPOQ,KLF4,LEP,NME1,SREBF1	 	
P3	 	STK11	-1.063	kinase	 	-1.833	 	-0.055	-1.604	1.06E-01	ALCAM,CDC42,CREBL2,FGFR2,HIF1A,JUNB,MCAM,MMP9,MRPS15,NR1D1,PPP1R2,PSMB5,RAB10,SORL1,TARS,TIAL1,TOP2A,TWF2	 	
P3	 	ACTL6A	1.270	other	Inhibited	-2.000	 	-0.059	-1.882	1.76E-01	BCL2L1,CCND2,FAS,HMOX1	 	
P3	 	MAFB	1.916	transcription regulator	 	-1.987	 	0.220	-2.425	1.97E-01	ACTB,ACTN1,ARHGDIA,NUAK1,PCK1	 	
P3	 	NR3C2	-1.250	ligand-dependent nuclear receptor	Inhibited	-2.143	 	0.178	-2.726	2.32E-01	BCL2L1,CTGF,DES,ECHDC2,EGR1,FKBP1A,FKBP4,FKBP5,HSPA9,PPAT,PPIB	 	
P3	 	HDAC4	-1.256	transcription regulator	 	1.964	 	-0.084	2.128	2.33E-01	C1QC,FOS,FST,HDAC2,HIF1A,KLF2,LMOD2,MAPK10,MMP9,NR4A1,TNFRSF12A,VCAM1	 	
P3	 	MTTP	-1.113	transporter	 	-1.953	 	-0.164	-1.633	2.84E-01	APOB,EIF2S1,GOT1,HSPA5	 	
P3	 	TSC1	1.229	other	 	-1.969	 	-0.073	-1.825	2.84E-01	DDIT3,FAM129A,FLNA,HMOX1	 	
P3	 	histone deacetylase inhibitor	 	chemical drug	Activated	2.000	 	0.133	1.734	2.84E-01	CPA3,FAS,IGFBP3,PHLDA2	 	
P3	 	BNIP3L	-1.294	other	Inhibited	-2.449	 	-0.184	-1.999	2.95E-01	BCL2L1,CCND3,EIF2AK1,SFRP1,TFRC,TOP2A	 	
P3	 	ATF3	-2.884	transcription regulator	 	1.982	 	-0.089	2.158	3.22E-01	ADIPOQ,ASNS,BHLHE41,CHAC1,DDIT3,NUPR1,PCK1	 	
P3	 	FOSL1	-2.547	transcription regulator	Activated	2.556	 	0.051	2.427	3.50E-01	EGR1,FOS,FOSB,JUNB,MMP9,PLAU,SERPINE2	 	
P3	 	FBXO32	-1.760	enzyme	Activated	2.157	 	0.169	1.683	3.83E-01	CALR,CCND2,HSPA5,HYOU1,MAPT,RPN1,SLC33A1,STT3A	 	
P3	 	NANOG	-1.556	transcription regulator	Inhibited	-2.121	 	0.150	-2.546	1.00E00	CCND2,CDK6,EGR1,FOS,FOSB,KLF4,LPCAT4,MAP1B	 	

Causal Networks for My Projects->David Bulger->P3

Diseases and Bio Functions for My Projects->David Bulger->P3
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Cell Death and Survival	cell death	cell death	4.03E-34	Decreased	-4.856	 	-2.649	NPM1,ASS1,VAC14,C1QA,NPAS2,POR,CCND3,CSE1L,GNA13,AIF1,YWHAG,LAIR1,SURF1,ANXA2,PRKACA,PSMA4,CTSB,ALCAM,PLTP,ADCYAP1,FTH1,EPHX1,HTATIP2,USP18,DDIT3,PSMD7,DAPK2,PRDX1,BAG6,ADIPOQ,PPIA,SMARCA4,RABL6,AAK1,GNG5,AMOT,TMEM123,OAS1,UCP2,MECOM,FCGR2A,PVR,CSTB,RPS16,EDIL3,CSF1,NR4A1,RPL37,SOX9,EEF1A1,SOCS3,AKR1C3,DNAJC15,GPC3,CBX5,CTSD,AK1,CHMP2A,CCT5,SNRPD1,UQCRFS1,MTMR2,NSMAF,STXBP1,GAS5,HDAC2,ASNA1,PFDN5,RPL37A,SMPD2,TXNRD1,AES,BCL2L1,RBX1,NAGLU,TFPI,PPAT,UBE2I,ETV5,PEBP1,SULF1,SCD,IGFBP4,TFEB,F2RL3,PCDHGB4,RPL7A,EIF2S1,HLA-G,PSMD10,COL6A1,STUB1,HSPB6,SEC61G,TP63,DVL1,CSRNP1,TRIM2,SOD1,RPS29,RBCK1,SLC25A5,MAP4K4,RPLP0,GFPT1,CTGF,RAN,MKI67,EIF6,GSS,RPS11,SGPL1,AHSA1,LGMN,PTP4A2,AFAP1,KLF8,ZBTB16,BIRC7,CAPN6,CENPB,JUNB,HMGA1,ROR1,BCAP29,NINJ1,FNDC1,RTN4,ARHGAP35,CCT3,EBNA1BP2,PDCD5,GSTP1,SORL1,GSTM5,BTG3,HLA-A,NQO2,LRP6,HYOU1,FKBP1A,CCAR2,ASNS,ATP6AP1,CDH11,MAFG,LYZ,CES1,PHB,TUB,HPGDS,RPS5,FKBP5,ACVR1C,RPL31,SMPD3,GJB2,RPS24,CD53,WSB1,PPIF,SYNGR2,EGR1,TRIM28,TIAL1,CALM1 (includes others),IMMT,GLIS2,SREBF1,BMF,USP22,NCAM1,PNO1,SLC31A1,PRPF19,PFN1,KCND3,CD4,MAP1B,UNC5B,CHTOP,METAP2,CAMK2D,SLC25A6,PLCE1,CDON,COMT,LYNX1,RPL19,CHST11,ANXA7,GSK3B,GPC1,C1QBP,RET,BCKDK,DSP,HK1,FERMT3,SLC6A8,FST,ACP2,GNG2,HSPA9,PHB2,SLC4A7,DGKE,SHOX,TPSAB1/TPSB2,CD3G,CDC42,MAPT,NUAK1,CD14,CLCN7,EIF5A,UTP11,CREBL2,GEM,TOLLIP,RAB1A,SFRP2,HIGD1A,ATF5,ILF2,MRPS30,HINT1,NAA38,THBS1,DKK3,DUSP10,ERBB4,HSPE1,EGLN3,OAZ1,OGDH,CACNG8,MAPKAPK2,FAM162A,CALR,SRR,BHLHE41,HSPH1,PHLDA3,MAP3K1,HYAL1,RPS21,CEBPB,EMP1,RPS4Y1,GBE1,C6,NCKAP1L,CPEB1,HLTF,PPP2R1B,SLC47A1,RPL38,PSG2,CSTA,WHSC1,RRM2B,CTSG,TMBIM6,MNAT1,PANX1,SLC9A1,ODC1,PTPRC,EMG1,GATAD2A,EIF4G2,LTF,HIGD2A,KEAP1,MCOLN3,KIF1A,SPTB,ATF4,STAM,TMSB10/TMSB4X,UNG,ALDOC,PPP1R1B,CNR1,FGFR2,TPM3,RPAP3,NPY5R,DCTD,CD52,DES,NDN,HAX1,HSPA8,BTG2,PSMA5,GPR65,ATMIN,GAPDH,TFRC,DUSP4,AARS,SQSTM1,ESR2,STEAP3,APOE,NME1,FBXO10,SLC4A2,PHLDA2,OSGIN1,SEC23B,GDF15,HSPB8,LGALS9,GRINA,CCT4,OGT,ARF6,HSP90AB1,UBE2K,DAB2,SERPINA1,SNRPD3,BCAP31,NFE2L2,S100A1,SIGMAR1,SRA1,TNFRSF1A,GNA12,SLC6A6,SLC39A6,LZTS2,TRIB3,SNCG,HSPA2,CPEB4,GRN,FOS,MYOC,NTRK3,SERPINH1,PPT1,CCT7,TPP1,PSAP,ARHGDIA,TSC22D2,ABCC3,BMP6,SGCD,ADRA1A,ICMT,DAD1,TRAF3,SESN2,ARL6IP5,MBP,ACO2,RACK1,BAG3,NME2,OGFOD1,RNASE1,TYMP,HSPA5,BIN1,CEBPG,CERS2,CD28,HSPA4,SAE1,RHOG,RPS13,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,GULP1,PFKFB3,BCAS2,PSMB5,FSTL3,YWHAB,PTPRQ,LAMA2,KCNK2,CNP,SLC12A7,RAPGEF3,SDHC,PPP1R11,THRA,CITED1,ARSA,TRIM35,KLF4,SLC3A2,FOSB,DNAJC5,ADAM12,DUSP1,TXN2,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,SIRPA,RPSA,CD151,PTGFR,MSR1,SRPX,PPIB,PYCARD,HNRNPK,MLH1,IRAK1,RAP1GDS1,SHC1,SLC19A3,MCAM,PPP1R2,SAA1,LOC102724428/SIK1,RHOBTB2,RPS3,LONP1,RAD23B,ATP13A2,GMFB,SLC20A1,VCAM1,EDNRB,DCTN3,NQO1,MGAT5,EMD,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ZPR1,FGF1,SERPINE2,CIDEA,KIFC3,CAPNS1,SLC33A1,PSMD2,COX5A,CHI3L1,APOB,MAF,COX8A,SH3BGRL3,HRAS,SH3GLB1,NCSTN,MIF4GD,APRT,DYNLL1,PEG10,CTSS,ABCC1,TXN,CALCRL,CFL1,NR1H3,STOML2,MTPN,CCND2,NR1D1,BSG,YARS,STIP1,MBD4,IL10RA,ALDOA,MAP2K3,LRP8,SFRP1,TCF7,CYR61,C3AR1,PHLPP1,ALK,S100A11,RAB32,ADAM17,RPS3A,PSMB10,UBQLN1,PAM16,DUSP6,CTNNA1,KAZN,PRAF2,FANCE,UCHL1,LIPA,RPL35,ACSM5,GBA,ANXA5,TOP2A,PRKCE,NACC1,PSMD14,STIM1,RPS12,AMFR,NDUFS4,PLAT,IL11RA,RPS19,ADRM1,LETM1,TYROBP,IMPDH2,ACTB,NABP1,CYP1B1,COPG1,AREL1,APP,EIF3G,FIS1,ITGB2,LAMP2,COL5A3,SUPV3L1,SREBF2,DOCK8,LIMS1,FCER1G,PEA15,PRMT5,FKBP4,TSPO,NR5A2,P2RY12,CYCS,CBX4,GABARAP,PLAU,GAB2,SLC7A11,PLP1,PFKFB1,VPS28,CCNI,CXCL12,SDC4,TAF10,TUBB,VDAC2,NR2F1,CTBP1,PAX5,G0S2,RPL13,ITGAV,CYBB,NEO1,SIAH2,RAD51C,CLCN3,KLF2,EIF2AK1,IGFBP6,SPP1,DNASE2,GPS2,LMO4,SGCG,CDK6,PSMC4,CDK2AP1,PKN1,RPL9,SEL1L,PPP2R1A,ADCYAP1R1,IL1RN,MAPK10,GNL3,VDAC1,PHF1,AKR1B1,RPL13A,PAFAH1B2,LEP,PRDX5,KLRD1,MMP14,VAPA,PKM,UGCG,CFTR,HIF1A,FAS,TNFRSF12A,TACR1,SOX17,HMOX1,CCDC88A,PARK7,PCK2,CSPG4,FLNA,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,HSD11B2,PSMA3,ARHGEF2,NSMF,SEMA3B,HCST,STK40,PI4KB,PRNP,TRAF7,TAF6,GABBR1,F13A1,NFKBIZ,CSF1R,NDUFA13,FAU,ENO1,TNFAIP8L2,LPAR1,FASTK,SLC16A1,MAT2A,MMP9	649	
Cell Death and Survival	necrosis	necrosis	1.69E-31	Decreased	-4.158	 	-2.698	NPM1,ASS1,VAC14,C1QA,CCND3,CSE1L,GNA13,YWHAG,LAIR1,SURF1,ANXA2,PRKACA,CTSB,PSMA4,ALCAM,ADCYAP1,FTH1,EPHX1,HTATIP2,USP18,PSMD7,DDIT3,DAPK2,PRDX1,BAG6,ADIPOQ,PPIA,SMARCA4,RABL6,AAK1,TMEM123,UCP2,MECOM,EDIL3,RPS16,CSF1,NR4A1,RPL37,SOX9,EEF1A1,SOCS3,DNAJC15,GPC3,CBX5,CTSD,CCT5,UQCRFS1,SNRPD1,NSMAF,STXBP1,GAS5,HDAC2,RPL37A,SMPD2,TXNRD1,BCL2L1,RBX1,NAGLU,PPAT,UBE2I,PEBP1,SULF1,IGFBP4,SCD,TFEB,F2RL3,PCDHGB4,RPL7A,EIF2S1,HLA-G,COL6A1,STUB1,HSPB6,SEC61G,TP63,DVL1,TRIM2,SOD1,RPS29,RBCK1,SLC25A5,RPLP0,GFPT1,CTGF,RAN,MKI67,EIF6,RPS11,SGPL1,AHSA1,LGMN,AFAP1,KLF8,ZBTB16,BIRC7,CAPN6,CENPB,JUNB,HMGA1,ROR1,RTN4,CCT3,EBNA1BP2,PDCD5,GSTP1,GSTM5,BTG3,NQO2,LRP6,HYOU1,FKBP1A,CCAR2,ASNS,CDH11,LYZ,CES1,PHB,FKBP5,RPS5,SMPD3,RPL31,ACVR1C,GJB2,RPS24,WSB1,PPIF,SYNGR2,TRIM28,EGR1,IMMT,GLIS2,SREBF1,BMF,USP22,NCAM1,PNO1,PRPF19,PFN1,CD4,MAP1B,UNC5B,CHTOP,METAP2,CAMK2D,SLC25A6,PLCE1,CDON,COMT,LYNX1,RPL19,GSK3B,GPC1,RET,BCKDK,DSP,HK1,SLC6A8,FST,HSPA9,GNG2,PHB2,DGKE,SHOX,TPSAB1/TPSB2,CDC42,MAPT,NUAK1,CD14,CLCN7,EIF5A,CREBL2,GEM,TOLLIP,SFRP2,ATF5,ILF2,HINT1,NAA38,DKK3,THBS1,ERBB4,HSPE1,EGLN3,OAZ1,CACNG8,MAPKAPK2,FAM162A,CALR,SRR,HSPH1,MAP3K1,HYAL1,RPS21,CEBPB,EMP1,RPS4Y1,GBE1,PPP2R1B,SLC47A1,RPL38,CSTA,PSG2,WHSC1,RRM2B,CTSG,TMBIM6,PANX1,MNAT1,SLC9A1,ODC1,PTPRC,EMG1,EIF4G2,LTF,MCOLN3,KIF1A,KEAP1,ATF4,STAM,TMSB10/TMSB4X,UNG,PPP1R1B,CNR1,FGFR2,RPAP3,DCTD,NDN,HAX1,HSPA8,BTG2,GPR65,PSMA5,ATMIN,GAPDH,TFRC,DUSP4,AARS,SQSTM1,ESR2,STEAP3,APOE,NME1,OSGIN1,GDF15,HSPB8,LGALS9,GRINA,CCT4,OGT,ARF6,HSP90AB1,UBE2K,DAB2,SERPINA1,SNRPD3,NFE2L2,S100A1,SIGMAR1,TNFRSF1A,GNA12,SLC6A6,SLC39A6,LZTS2,TRIB3,CPEB4,GRN,FOS,MYOC,NTRK3,SERPINH1,PPT1,CCT7,TPP1,PSAP,ARHGDIA,TSC22D2,BMP6,SGCD,ADRA1A,ICMT,TRAF3,SESN2,MBP,ACO2,RACK1,BAG3,OGFOD1,TYMP,RNASE1,HSPA5,CD28,HSPA4,SAE1,RHOG,RPS13,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,GULP1,PFKFB3,BCAS2,PSMB5,FSTL3,YWHAB,PTPRQ,LAMA2,CNP,RAPGEF3,PPP1R11,THRA,SDHC,CITED1,KLF4,SLC3A2,FOSB,DNAJC5,ADAM12,DUSP1,TXN2,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,SIRPA,RPSA,CD151,MSR1,SRPX,PYCARD,HNRNPK,MLH1,IRAK1,RAP1GDS1,SLC19A3,SHC1,MCAM,SAA1,LOC102724428/SIK1,RHOBTB2,RPS3,LONP1,RAD23B,GMFB,ATP13A2,SLC20A1,VCAM1,EDNRB,DCTN3,NQO1,MGAT5,EMD,HSPD1,PSME3,NFE2L1,FGF1,SERPINE2,CIDEA,KIFC3,CAPNS1,PSMD2,COX5A,CHI3L1,APOB,COX8A,HRAS,SH3GLB1,MIF4GD,APRT,DYNLL1,CTSS,ABCC1,TXN,CALCRL,STOML2,NR1H3,MTPN,CCND2,NR1D1,BSG,YARS,STIP1,MBD4,ALDOA,MAP2K3,SFRP1,TCF7,CYR61,C3AR1,PHLPP1,ALK,S100A11,ADAM17,RAB32,RPS3A,PSMB10,UBQLN1,DUSP6,CTNNA1,KAZN,PRAF2,FANCE,UCHL1,LIPA,RPL35,ACSM5,GBA,TOP2A,PRKCE,PSMD14,STIM1,NACC1,RPS12,PLAT,IL11RA,RPS19,ADRM1,LETM1,TYROBP,ACTB,NABP1,CYP1B1,COPG1,APP,EIF3G,ITGB2,COL5A3,LAMP2,SREBF2,LIMS1,DOCK8,FCER1G,PEA15,FKBP4,PRMT5,NR5A2,P2RY12,CYCS,PLAU,GAB2,PLP1,SLC7A11,PFKFB1,VPS28,CCNI,CXCL12,SDC4,TUBB,VDAC2,NR2F1,CTBP1,G0S2,RPL13,ITGAV,CYBB,NEO1,SIAH2,RAD51C,KLF2,EIF2AK1,IGFBP6,SPP1,DNASE2,GPS2,LMO4,SGCG,PSMC4,CDK6,CDK2AP1,PKN1,RPL9,PPP2R1A,ADCYAP1R1,IL1RN,MAPK10,GNL3,VDAC1,PHF1,AKR1B1,RPL13A,LEP,MMP14,VAPA,PKM,UGCG,HIF1A,FAS,SOX17,TACR1,HMOX1,PARK7,PCK2,CSPG4,FLNA,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,HSD11B2,PSMA3,NSMF,SEMA3B,HCST,PI4KB,PRNP,TRAF7,TAF6,GABBR1,F13A1,NFKBIZ,CSF1R,NDUFA13,FAU,ENO1,TNFAIP8L2,LPAR1,SLC16A1,MAT2A,MMP9	526	
Cellular Growth and Proliferation	proliferation	proliferation of cells	4.17E-30	Increased	5.774	 	1.866	NPM1,ADAMTS8,SPRY4,GNB1,POR,CCND3,ATG9A,GLB1,CSE1L,GNA13,AIF1,EIF1AY,AHCY,YWHAG,NKIRAS2,LAIR1,SURF1,ANXA2,PLAG1,MYL9,CD300C,PRKACA,PSMA4,CTSB,ALCAM,ELMO2,ADCYAP1,ACTG1,FTH1,USP18,HTATIP2,FHL1,DDIT3,GBP1,DAPK2,PRDX1,BAG6,ADIPOQ,PPIA,RPL26,SMARCA4,SYNM,RABL6,AMOT,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,IPO7,RNF6,MARCKSL1,CSF1,NR4A1,WBP2,SOX9,EEF1A1,SOCS3,AKR1C3,SEPT9,RABEP1,EML4,DIRAS1,GPC3,CTSD,HS6ST1,STC2,CCT5,ERAL1,ADAMTS5,NAGA,GAS5,HDAC2,STK39,PFDN5,CREG1,FYB,SMPD2,TXNRD1,AES,BCL2L1,ADRA2A,RBX1,LSM1,TFPI,PPAT,UBE2I,ETV5,PEBP1,SULF1,SCD,IGFBP4,DDX21,ALG14,SUMO3,LITAF,TFEB,HLA-G,PSMD10,COL6A1,STUB1,LASP1,HSPB6,SEC61G,PREB,MT-ATP6,TP63,AKR1C1/AKR1C2,USMG5,DVL1,SOD1,TSN,RBCK1,FECH,SLC25A5,MAP4K4,CTGF,RAN,CA12,MKI67,EIF6,GSS,RAD23A,SNX12,ZBTB7B,SGPL1,AHSA1,PRG4,PTP4A2,MGAT4B,AFAP1,KLF8,ZBTB16,TESK1,BIRC7,CAPN6,CENPB,PTP4A3,DKC1,JUNB,HMGA1,ROR1,NINJ1,SH3GL1,INPP4B,RTN4,CCT3,EBNA1BP2,B3GNT5,SETBP1,PDCD5,GSTP1,BTG3,NQO2,LRP6,TTLL4,FKBP1A,RUVBL1,GPC4,CCAR2,ASNS,H2AFZ,CDH11,ENAH,MAFG,LYZ,PHB,RHOD,TXNL1,HPGDS,FKBP5,ACVR1C,SLC30A1,SMPD3,GJB2,WSB1,PLXNA1,CD209,PTPRK,PPIF,EGR1,TRIM28,TIAL1,CASK,COPS3,STS,CALM1 (includes others),CCDC85B,IMMT,SREBF1,TREM2,BMF,USP22,RNF187,NCAM1,NAB2,PLCB2,PRPF19,SLC31A1,PFN1,KCND3,UBE2A,ARF1,CD4,MAP1B,UNC5B,CD63,CHTOP,METAP2,CAMK2D,PTGES2,SLC25A6,PLCE1,CDON,COMT,CHST11,ANXA7,GSK3B,GPC1,C1QBP,AAGAB,RET,DSP,HK1,FST,GSDMB,PSMF1,GNG2,CLTC,IRX6,MAGED2,TPSAB1/TPSB2,CMC2,CD3G,ZFAND3,CDC42,SH2B3,MAPT,RARRES3,NUAK1,CD14,CLCN7,EIF5A,SRM,GEM,RAB1A,SFRP2,ATF5,ILF2,CD83,NELFE,HINT1,NAA38,THBS1,DKK3,DUSP10,ERBB4,EGLN3,OAZ1,CYGB,MAPKAPK2,ADAMTS15,CALR,MAP3K1,RNF43,HYAL1,VSIG4,CEBPB,IL20RB,EDF1,EMP1,P4HA1,TMEM2,PAG1,EPHB3,NUCB2,CPEB1,NCKAP1L,ADAM9,HLTF,PPP2R1B,WHSC1,TIGIT,CTSG,COL8A1,MNAT1,SLC9A1,CLIP1,ODC1,FADS3,PTPRC,EIF4G2,LTF,KEAP1,KIF1A,ST6GALNAC2,ATF4,STAM,LMX1A,TMSB10/TMSB4X,MGAT1,LCP1,PPP1R1B,CNR1,FGFR2,TPM3,FLOT1,NPY5R,DES,NDN,HAX1,HSPA8,PYGO2,TMEM127,MICU1,FSCN1,BTG2,ATMIN,GAPDH,TFRC,DUSP4,AARS,SQSTM1,ESR2,STEAP3,APOE,NME1,PLXNA3,PHLDA2,OSGIN1,GDF15,HSPB8,EEF1B2,LGALS9,PROX1,COPS8,ATRAID,MMP25,OGT,ARF6,HSP90AB1,TNXB,FBXW11,PLIN2,DAB2,SERPINA1,CSNK2B,BCAP31,NFE2L2,P4HA2,S100A1,STT3B,SRA1,TNFRSF1A,GNA12,SLC39A6,ALOX5AP,LZTS2,TRIB3,SNCG,GRN,MRAP,FOS,MYOC,NTRK3,SERPINH1,PPT1,EIF4A1,MBD3,CCT7,PSAP,ARHGDIA,BMPER,ABCC3,BMP6,PPIL1,SIGLEC6,ID4,ADRA1A,ICMT,TRAF3,NCDN,USP5,SCAMP2,ARL6IP5,MBP,RACK1,NME2,OGFOD1,SLC35F6,CES2,HSPA5,BIN1,NNMT,CD28,HSPA4,SAE1,RHOG,ENTPD5,CXCL14,HOXA10,NUPR1,HOXA7,CHMP1A,PFKFB3,FSTL3,RERG,PTPRQ,LAMA2,KCNK2,CNP,HNRNPAB,RAPGEF3,POLR2K,THRA,CITED1,TRIM35,KLF4,SLC3A2,FOSB,SDCBP,TLN2,ADAM12,DUSP1,TXN2,XRCC6,ALDH1A2,LIMA1,IGFBP3,CAPN2,PIK3AP1,IRF8,MEGF8,CCPG1,SIRPA,RPSA,CD151,DOK5,PTGFR,MSR1,PPIB,PYCARD,MECR,COPE,HNRNPK,MLH1,IRAK1,RAP1GDS1,SHC1,MCAM,SAA1,LOC102724428/SIK1,RNH1,RHOBTB2,UBIAD1,LONP1,SLC20A1,VCAM1,EDNRB,NPY1R,NQO1,MGAT5,EMD,HSPD1,PSME3,AIFM2,DEGS1,ZPR1,ATIC,FGF1,SERPINE2,PDAP1,CXCL16,SHB,CISD1,CAPNS1,PSMD2,TBC1D7,CHI3L1,NR6A1,APOB,MAF,HRAS,NCSTN,BCAT1,PEG10,CTSS,ABCC1,HADHB,TXN,APEX2,WNT5B,HNRNPA0,CALCRL,RIMS3,CFL1,TUBB2A,NR1H3,CTPS1,C9orf69,MTPN,CCND2,NR1D1,VKORC1,BSG,YARS,MS4A4A,STIP1,IL10RA,ALDOA,GLUL,MAP2K3,SFRP1,TCF7,CYR61,C3AR1,PHLPP1,ALK,S100A11,ATP5G1,ADAM17,RALA,LAPTM5,RPS3A,PSMB10,DUSP6,HMGN1,CTNNA1,FOLR2,DCLK1,SP2,TAX1BP3,UCHL1,LIPA,C1QTNF3,SEC61A1,SRGAP1,HLCS,TOP2A,PRKCE,NACC1,STIM1,TPO,AMFR,NDUFS4,PLAT,IL11RA,RPS19,TYROBP,IMPDH2,ACTB,NABP1,WDR12,CYP1B1,POMGNT1,ARL3,APP,FIS1,B4GALT2,ITGB2,FTL,SUPV3L1,PPP1R16B,DOCK8,LIMS1,ADCY1,FCER1G,PEA15,PRMT5,FKBP4,TSPO,NR5A2,DVL3,CBX4,GABARAP,PLAU,MVD,HOXB5,GAB2,SLC7A11,PLP1,CCNI,VPS28,CMA1,CXCL12,SDC4,TUBB,NR2F1,CTBP1,PAX5,PGD,G0S2,EIF5,CYBB,ITGAV,IFI30,NEO1,SLC7A5,CLCN3,KLF2,EIF2AK1,PTX3,IGFBP6,SPP1,GPS2,GCNT2,CDK6,PSMC4,CDK2AP1,PKN1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,IL1RN,ATP6V0D1,MAPK10,GNL3,UHMK1,VDAC1,PHF1,AKR1B1,JTB,CNBP,LEP,EPB41L3,PDGFA,KLRD1,MMP14,VAPA,PKM,UGCG,CFTR,HIF1A,STXBP4,NAA10,FAS,TNFRSF12A,TACR1,SOX17,HMOX1,CCDC88A,SLFN5,PARK7,PCK2,CSPG4,FLNA,KCNMA1,ANXA1,EFNB1,TGFB2,KIT,TCP1,HSD11B2,ARHGEF2,SELENOH,NSMF,NR2F6,SEMA3B,ACTN1,PRNP,NDUFAF3,COX17,TAF6,VANGL1,GABBR1,QSOX1,ZBTB7C,MKNK2,CSF1R,NDUFA13,ENO1,WARS,TNFAIP8L2,LPAR1,SLC16A1,CLDN2,CARM1,MMP9,SHMT2	680	
Protein Synthesis	metabolism	metabolism of protein	1.25E-24	Increased	2.947	 	0.826	CSTA,NPM1,CTSG,ODC1,PTPRC,EIF4G2,ETF1,ATF4,CLN6,FBXO8,HSPA8,CTSA,MRPL17,BTG2,CTSB,GAPDH,PLTP,SQSTM1,RPL41,EIF3K,APOE,USP18,DDIT3,BAG6,DPM2,ADIPOQ,HSPB8,CCT4,OGT,FBXW11,UBE2K,AAK1,SERPINA1,STT3B,MT-TY,CSTB,RNF6,CPEB4,FOS,MRPS7,CSF1,FAM129A,DERL1,EIF4A1,CCT7,TPP1,RPL37,SOX9,EEF1A1,SOCS3,TRAF3,RACK1,BAG3,OGFOD1,GPC3,MRM2,NPC1L1,HSPA5,CTSD,CCT5,DPM3,CHMP1A,STXBP1,PSMB5,HDAC2,MT-TC,EIF2B3,AURKAIP1,RAPGEF3,EIF4E2,BCL2L1,ADAM12,EDEM1,IGFBP3,NAGLU,CAPN2,PPAT,UBE2I,UBXN1,PYCARD,PPIB,EIF2S1,VPS4A,HNRNPK,FARSB,F8,STUB1,PPP1R2,TRABD2A,MT-TS1,RPS3,LONP1,ATP13A2,PATL1,TP63,DVL1,DNAJC1,SOD1,HSPD1,RPS29,PSME3,SERPINE2,CAPNS1,PSMD2,SPCS1,APOB,SH3GLB1,NCSTN,EIF6,RAD23A,SNX12,LGMN,CTSS,GPR26,NANOS1,DKC1,NR1H3,CPA3,JUNB,MTPN,STIP1,CCT3,MAP2K3,SFRP1,PHLPP1,RPL24,SORL1,ADAM17,RPS3A,FKBP1A,CCAR2,H2AFZ,UCHL1,GBA,PHB,PSMD14,SARS,RPS5,SMPD3,AMFR,MT-TD,RPS24,PLAT,ADRM1,RPL17,CYP1B1,PSMD8,APP,COPG1,EIF3G,MRPL51,LAMP2,SREBF1,DVL3,PLAU,MT-RNR1,GAB2,PFN1,VPS28,CD4,CMA1,SDC4,METAP2,CNDP2,PABPC4,DPP3,EIF5,RPL19,IFI30,SIAH2,GSK3B,GPC1,KLF2,VPS11,EIF2AK1,SPP1,FST,PSMF1,PHB2,PSMC4,ST6GALNAC3,MARS,EPRS,SEL1L,UBE2D2,IL1RN,MAPT,EIF5A,UBE2E1,CNBP,RPL13A,MT-TP,RNPEP,CREBL2,LEP,RNF165,MMP14,SLC7A1,CFTR,STXBP4,MT-TN,FAS,SOX17,NLK,PARK7,FLNA,THBS1,CSPG4,ANXA1,F5,SENP3,TCP1,OAZ1,ARHGEF2,PRNP,CALR,RAB7A,RPL30,MKNK2,NDUFA13,RPS4Y1,WARS,RPS27L,CPEB1,ADAM9,MMP9,RPL38	227	
Cell Death and Survival	cell death	cell death of tumor cell lines	1.00E-23	Decreased	-2.984	 	-2.124	PSG2,NPM1,CSTA,WHSC1,RRM2B,CTSG,TMBIM6,SLC9A1,ODC1,PTPRC,EMG1,CCND3,EIF4G2,CSE1L,KEAP1,MCOLN3,ATF4,TMSB10/TMSB4X,YWHAG,LAIR1,PPP1R1B,CNR1,FGFR2,RPAP3,ANXA2,DCTD,NDN,HAX1,HSPA8,BTG2,GPR65,PRKACA,ATMIN,CTSB,GAPDH,ALCAM,TFRC,DUSP4,SQSTM1,ESR2,FTH1,APOE,NME1,HTATIP2,USP18,DDIT3,PSMD7,DAPK2,OSGIN1,PRDX1,BAG6,GDF15,HSPB8,ADIPOQ,LGALS9,PPIA,GRINA,CCT4,OGT,RABL6,HSP90AB1,UBE2K,DAB2,NFE2L2,TMEM123,UCP2,MECOM,TNFRSF1A,SLC39A6,LZTS2,TRIB3,GRN,FOS,NTRK3,PPT1,NR4A1,CCT7,PSAP,ARHGDIA,SOX9,TSC22D2,BMP6,ICMT,SOCS3,TRAF3,SESN2,MBP,ACO2,RACK1,BAG3,OGFOD1,RNASE1,TYMP,DNAJC15,HSPA5,GPC3,CBX5,CD28,CTSD,HSPA4,SAE1,ENTPD5,PACS2,NUPR1,CCT5,HOXA7,UQCRFS1,GULP1,BCAS2,HDAC2,PTPRQ,SDHC,PPP1R11,THRA,SMPD2,KLF4,TXNRD1,SLC3A2,FOSB,BCL2L1,DUSP1,TXN2,XRCC6,RBX1,IGFBP3,CAPN2,IRF8,SIRPA,PPAT,PEBP1,SULF1,SCD,IGFBP4,TFEB,MSR1,SRPX,PYCARD,EIF2S1,HNRNPK,MLH1,IRAK1,RAP1GDS1,HLA-G,SHC1,STUB1,RHOBTB2,RPS3,LONP1,RAD23B,ATP13A2,SEC61G,TP63,DCTN3,DVL1,NQO1,SOD1,HSPD1,NFE2L1,KIFC3,CAPNS1,PSMD2,COX5A,SLC25A5,RPLP0,CTGF,APOB,COX8A,HRAS,SH3GLB1,MIF4GD,DYNLL1,AHSA1,ABCC1,AFAP1,TXN,KLF8,ZBTB16,BIRC7,CAPN6,CENPB,STOML2,JUNB,HMGA1,ROR1,CCND2,YARS,RTN4,CCT3,MAP2K3,SFRP1,CYR61,GSTP1,PHLPP1,ALK,S100A11,RAB32,ADAM17,BTG3,UBQLN1,LRP6,FKBP1A,KAZN,CCAR2,ASNS,PRAF2,FANCE,UCHL1,ACSM5,PHB,TOP2A,PRKCE,NACC1,PSMD14,STIM1,FKBP5,ACVR1C,SMPD3,PLAT,RPS24,WSB1,RPS19,ADRM1,LETM1,SYNGR2,EGR1,TRIM28,NABP1,CYP1B1,APP,EIF3G,LAMP2,IMMT,LIMS1,SREBF1,BMF,USP22,PEA15,PRMT5,CYCS,PLAU,NCAM1,SLC7A11,PRPF19,PFKFB1,VPS28,CD4,UNC5B,CXCL12,CHTOP,VDAC2,CTBP1,G0S2,SLC25A6,CDON,ITGAV,SIAH2,GSK3B,GPC1,RET,RAD51C,KLF2,HK1,IGFBP6,SPP1,FST,LMO4,GPS2,HSPA9,CDK6,PHB2,PKN1,PPP2R1A,CDC42,IL1RN,MAPT,MAPK10,NUAK1,CLCN7,EIF5A,VDAC1,PHF1,AKR1B1,GEM,TOLLIP,LEP,SFRP2,MMP14,PKM,ILF2,UGCG,HIF1A,FAS,HMOX1,HINT1,NAA38,PARK7,PCK2,CSPG4,THBS1,DKK3,ERBB4,TGFB2,KIT,TCP1,EGLN3,OAZ1,SEMA3B,HCST,MAPKAPK2,PRNP,TRAF7,CALR,TAF6,MAP3K1,HYAL1,CEBPB,NFKBIZ,CSF1R,NDUFA13,FAU,ENO1,GBE1,MAT2A,PPP2R1B,MMP9	325	
Cell Death and Survival	apoptosis	apoptosis	3.57E-23	Decreased	-4.190	 	-2.055	NPM1,ASS1,C1QA,POR,CCND3,CSE1L,AIF1,GNA13,LAIR1,SURF1,ANXA2,PRKACA,CTSB,ALCAM,ADCYAP1,FTH1,EPHX1,HTATIP2,USP18,DDIT3,DAPK2,PRDX1,BAG6,ADIPOQ,PPIA,SMARCA4,RABL6,GNG5,AMOT,TMEM123,OAS1,UCP2,MECOM,CSTB,EDIL3,CSF1,NR4A1,RPL37,SOX9,EEF1A1,SOCS3,DNAJC15,GPC3,CBX5,CTSD,NSMAF,STXBP1,GAS5,HDAC2,SMPD2,TXNRD1,BCL2L1,AES,RBX1,TFPI,UBE2I,ETV5,PEBP1,SULF1,IGFBP4,SCD,TFEB,F2RL3,PCDHGB4,EIF2S1,HLA-G,PSMD10,STUB1,HSPB6,SEC61G,TP63,DVL1,CSRNP1,TRIM2,SOD1,RBCK1,SLC25A5,MAP4K4,RPLP0,GFPT1,CTGF,MKI67,EIF6,SGPL1,AHSA1,LGMN,PTP4A2,ZBTB16,BIRC7,CAPN6,CENPB,JUNB,HMGA1,ROR1,NINJ1,FNDC1,RTN4,ARHGAP35,PDCD5,GSTP1,GSTM5,NQO2,LRP6,HYOU1,FKBP1A,CCAR2,ASNS,CDH11,PHB,TUB,HPGDS,FKBP5,SMPD3,ACVR1C,RPS24,CD53,WSB1,PPIF,TRIM28,EGR1,TIAL1,IMMT,GLIS2,SREBF1,BMF,USP22,NCAM1,PRPF19,PFN1,KCND3,CD4,MAP1B,UNC5B,CAMK2D,SLC25A6,PLCE1,CDON,LYNX1,CHST11,ANXA7,GSK3B,C1QBP,RET,DSP,HK1,FST,HSPA9,GNG2,PHB2,DGKE,SLC4A7,SHOX,TPSAB1/TPSB2,CDC42,MAPT,NUAK1,CD14,EIF5A,CREBL2,UTP11,SFRP2,GEM,HIGD1A,ATF5,MRPS30,HINT1,NAA38,DKK3,THBS1,DUSP10,ERBB4,HSPE1,EGLN3,MAPKAPK2,FAM162A,CALR,BHLHE41,HSPH1,PHLDA3,MAP3K1,HYAL1,CEBPB,C6,NCKAP1L,CPEB1,HLTF,PPP2R1B,CSTA,PSG2,WHSC1,RRM2B,CTSG,TMBIM6,PANX1,MNAT1,SLC9A1,ODC1,PTPRC,GATAD2A,EIF4G2,LTF,HIGD2A,MCOLN3,KEAP1,ATF4,TMSB10/TMSB4X,UNG,ALDOC,PPP1R1B,CNR1,FGFR2,NPY5R,DES,NDN,HAX1,HSPA8,BTG2,GPR65,ATMIN,GAPDH,TFRC,DUSP4,AARS,SQSTM1,ESR2,STEAP3,APOE,NME1,SLC4A2,FBXO10,PHLDA2,OSGIN1,GDF15,SEC23B,HSPB8,LGALS9,CCT4,OGT,ARF6,HSP90AB1,DAB2,SERPINA1,BCAP31,NFE2L2,S100A1,SIGMAR1,SRA1,TNFRSF1A,GNA12,SLC6A6,SLC39A6,LZTS2,TRIB3,SNCG,HSPA2,CPEB4,GRN,FOS,MYOC,NTRK3,SERPINH1,PPT1,PSAP,ARHGDIA,BMP6,ADRA1A,ICMT,TRAF3,DAD1,ARL6IP5,ACO2,RACK1,BAG3,NME2,OGFOD1,TYMP,RNASE1,HSPA5,BIN1,CD28,HSPA4,SAE1,RHOG,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,BCAS2,FSTL3,PTPRQ,YWHAB,CNP,LAMA2,RAPGEF3,PPP1R11,THRA,SDHC,TRIM35,CITED1,KLF4,FOSB,DNAJC5,ADAM12,DUSP1,TXN2,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,SIRPA,CD151,PTGFR,MSR1,SRPX,PYCARD,HNRNPK,MLH1,IRAK1,SHC1,MCAM,SAA1,PPP1R2,LOC102724428/SIK1,RHOBTB2,RPS3,RAD23B,GMFB,SLC20A1,EDNRB,NQO1,EMD,HSPD1,AIFM2,ZPR1,DEGS1,NFE2L1,FGF1,SERPINE2,CIDEA,KIFC3,CAPNS1,COX5A,CHI3L1,SH3BGRL3,COX8A,HRAS,SH3GLB1,NCSTN,DYNLL1,CTSS,ABCC1,TXN,CALCRL,CFL1,STOML2,NR1H3,MTPN,CCND2,NR1D1,BSG,YARS,STIP1,MBD4,IL10RA,ALDOA,MAP2K3,SFRP1,CYR61,C3AR1,PHLPP1,ALK,S100A11,ADAM17,RAB32,RPS3A,PSMB10,UBQLN1,PAM16,DUSP6,CTNNA1,KAZN,PRAF2,UCHL1,LIPA,ACSM5,ANXA5,TOP2A,PRKCE,STIM1,NACC1,AMFR,PLAT,RPS19,TYROBP,CYP1B1,AREL1,APP,ITGB2,FIS1,SUPV3L1,COL5A3,SREBF2,LIMS1,DOCK8,FCER1G,FKBP4,PRMT5,PEA15,TSPO,CYCS,CBX4,GABARAP,PLAU,GAB2,PLP1,SLC7A11,VPS28,CCNI,CXCL12,SDC4,TAF10,VDAC2,PAX5,CTBP1,NR2F1,G0S2,ITGAV,CYBB,SIAH2,KLF2,EIF2AK1,IGFBP6,SPP1,DNASE2,GPS2,LMO4,SGCG,CDK6,CDK2AP1,PKN1,SEL1L,PPP2R1A,ADCYAP1R1,IL1RN,MAPK10,GNL3,VDAC1,PHF1,AKR1B1,PAFAH1B2,LEP,PRDX5,MMP14,PKM,UGCG,CFTR,HIF1A,FAS,TNFRSF12A,SOX17,TACR1,HMOX1,CCDC88A,PARK7,FLNA,KCNMA1,CSPG4,ANXA1,EFNB1,TGFB2,KIT,TCP1,HSD11B2,NSMF,SEMA3B,HCST,STK40,TRAF7,PRNP,TAF6,GABBR1,NFKBIZ,CSF1R,NDUFA13,FAU,ENO1,TNFAIP8L2,LPAR1,FASTK,MAT2A,MMP9	495	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of tumor cell lines	1.05E-19	Increased	4.049	 	1.624	NPM1,WHSC1,CTSG,MNAT1,SLC9A1,CLIP1,ODC1,POR,CCND3,CSE1L,KEAP1,KIF1A,TMSB10/TMSB4X,LCP1,YWHAG,LAIR1,PPP1R1B,FGFR2,FLOT1,ANXA2,NDN,MYL9,MICU1,FSCN1,BTG2,PRKACA,PSMA4,CTSB,GAPDH,ALCAM,TFRC,DUSP4,ADCYAP1,ESR2,STEAP3,FTH1,NME1,HTATIP2,USP18,DDIT3,DAPK2,OSGIN1,GDF15,HSPB8,EEF1B2,ADIPOQ,PROX1,COPS8,SMARCA4,SYNM,OGT,ARF6,RABL6,TNXB,DAB2,CSNK2B,AMOT,NFE2L2,S100A1,PLOD2,MECOM,TNFRSF1A,SLC39A6,IPO7,TRIB3,SNCG,GRN,FOS,NTRK3,CSF1,PPT1,EIF4A1,NR4A1,WBP2,SOX9,BMP6,PPIL1,EEF1A1,SOCS3,AKR1C3,SEPT9,USP5,RACK1,NME2,CES2,HSPA5,GPC3,BIN1,CD28,CTSD,SAE1,ENTPD5,HOXA7,ERAL1,ADAMTS5,PFKFB3,FSTL3,HDAC2,PTPRQ,KCNK2,CREG1,THRA,CITED1,TRIM35,SMPD2,KLF4,SLC3A2,FOSB,BCL2L1,SDCBP,ADAM12,DUSP1,XRCC6,RBX1,IGFBP3,IRF8,TFPI,UBE2I,RPSA,CD151,PEBP1,SCD,DDX21,SUMO3,IGFBP4,TFEB,HNRNPK,MLH1,RAP1GDS1,SHC1,STUB1,LOC102724428/SIK1,RHOBTB2,UBIAD1,HSPB6,SEC61G,VCAM1,TP63,USMG5,DVL1,NQO1,MGAT5,SOD1,DEGS1,FGF1,RBCK1,CISD1,TBC1D7,MAP4K4,CTGF,APOB,RAN,HRAS,NCSTN,MKI67,RAD23A,AHSA1,PEG10,AFAP1,TXN,ZBTB16,BIRC7,CAPN6,CENPB,PTP4A3,TUBB2A,NR1H3,JUNB,HMGA1,ROR1,SH3GL1,INPP4B,CCND2,VKORC1,BSG,ALDOA,MAP2K3,SFRP1,CYR61,PHLPP1,ALK,ADAM17,RALA,DUSP6,LRP6,TTLL4,ASNS,H2AFZ,CDH11,ENAH,UCHL1,PHB,PRKCE,STIM1,FKBP5,ACVR1C,SMPD3,PLAT,WSB1,PTPRK,PPIF,ACTB,EGR1,TRIM28,NABP1,WDR12,COPS3,CYP1B1,APP,FTL,IMMT,SREBF1,FCER1G,PRMT5,TSPO,NR5A2,DVL3,PLAU,NCAM1,NAB2,GAB2,SLC7A11,PFN1,VPS28,ARF1,CD4,MAP1B,CXCL12,SDC4,TUBB,NR2F1,CTBP1,PGD,CAMK2D,SLC25A6,PLCE1,EIF5,ITGAV,NEO1,SLC7A5,ANXA7,GSK3B,GPC1,C1QBP,AAGAB,RET,CLCN3,KLF2,HK1,EIF2AK1,SPP1,FST,GSDMB,GPS2,CDK6,CDK2AP1,CMC2,SEL1L,PPP2R1A,ZFAND3,CDC42,IL1RN,SH2B3,RARRES3,GNL3,EIF5A,PHF1,SRM,LEP,EPB41L3,ATF5,PDGFA,MMP14,PKM,UGCG,HIF1A,NAA10,SOX17,HMOX1,CCDC88A,NAA38,SLFN5,PCK2,CSPG4,THBS1,FLNA,DKK3,ANXA1,ERBB4,TGFB2,KIT,TCP1,OAZ1,HSD11B2,ARHGEF2,NR2F6,SEMA3B,MAPKAPK2,ACTN1,PRNP,NDUFAF3,ADAMTS15,CALR,TAF6,VANGL1,HYAL1,ZBTB7C,CEBPB,MKNK2,NDUFA13,EMP1,TMEM2,SLC16A1,NUCB2,CLDN2,ADAM9,MMP9	317	
Neurological Disease, Skeletal and Muscular Disorders	neuromuscular disease	neuromuscular disease	1.25E-19	 	0.763	 	1.037	NPM1,RRM2B,PTPRC,GNB1,LTF,CSE1L,KEAP1,SYPL1,ATF4,AHCY,PPP1R1B,CNR1,SURF1,FLOT1,TPM3,ANXA2,RPH3A,RASL12,CD52,HSPA8,PSMA4,ALCAM,GAPDH,SQSTM1,SCN11A,EIF3K,FTH1,APOE,NME1,GBP1,DDIT3,BAG6,PPIA,CETN2,MAL2,TNXB,LY6E,SERPINA1,CSNK2B,PLOD2,OAS1,FCGR2A,MLF2,TNFRSF1A,TRIB3,SNCG,PSMB6,MYO5A,FOS,MT-ND1,SEPHS1,NR4A1,SOX9,ADRA1A,ID4,EEF1A1,ARL6IP5,MBP,SCN7A,MT1M,HSPA5,AK1,RHOG,STRN4,TUBA1C,NDUFA8,GAS5,PSMB5,CNP,KCNK2,LAMA2,BCL2L1,ADRA2A,XRCC6,ETV5,POLE3,RPSA,PEBP1,SUMO3,ALG14,SCD,SLC1A4,SRPX,COPE,ALAS1,NDUFA2,FARSB,HLA-G,PREPL,STUB1,PPP1R2,MCAM,CRYM,ATP13A2,PSAT1,CAPZB,DNAJC1,SOD1,TSN,ATP6V1E1,KCTD13,CAPNS1,CHI3L1,TUBA1B,GFPT1,CTGF,AHCYL1,CA12,RAN,PCDH7,HRAS,GHITM,CTSS,HADHB,CHCHD2,SYT2,TXN,ZBTB16,SLC24A3,ELOVL1,JUNB,NGRN,CD68,NR1D1,RTN4,GSTP1,SORL1,ADAM17,RPS3A,NQO2,HMGN1,KAZN,FKBP1A,CCAR2,UCHL1,GBA,SCN3A,TOP2A,RPL31,MYL12A,IMPDH2,EGR1,ACTB,RPL17,ARL3,APP,FTL,PSME1,LAMP2,UQCR10,FKBP4,TSPO,CYCS,PFN1,KCND3,PFKFB1,MAP1B,CXCL12,ATP5L,SDC4,DYNLT1,FAM173A,SLC25A6,RPL13,COMT,GSK3B,SPP1,GPS2,ATP6V1A,LMCD1,IL1RN,MAPT,RARRES3,RPL13A,MT-TP,SRM,COX7B,LEP,HIGD1A,PKM,EPSTI1,UGCG,FAS,NELFE,HMOX1,HINT1,PARK7,KCNMA1,DKK3,ANXA1,MICALL1,PRNP,CALR,ADCY2,GABBR1,NDUFA13,P4HA1,MT-ND5,CYC1,UQCRC1,ATP6V1B2	201	
Organismal Survival	organismal death	organismal death	7.43E-19	Decreased	-12.273	bias	 	NPM1,PCLO,ASS1,VAC14,C1QA,SPRY4,POR,GNB1,ATG9A,CCND3,CSE1L,GNA13,SURF1,PRKACA,CTSB,ATOX1,NHLH1,ADCYAP1,ACTG1,FTH1,USP18,PRDX1,BAG6,ADIPOQ,PPIA,HEXA,SMARCA4,LY6E,GNG5,AMOT,UCP2,MECOM,PVR,MARCKSL1,KIF7,CSF1,DERL1,SOX9,SOCS3,AKR1C3,GPC3,CTSD,HS6ST1,ABCB11,MTMR2,STXBP1,HDAC2,UROS,ASNA1,MAPK8IP2,FIG4,EIF4E2,TXNRD1,BCL2L1,AES,ADRA2A,RBX1,NAGLU,TFPI,UBE2I,SUMO3,SULF1,TFEB,F2RL3,PCDHGB4,EIF2S1,HLA-G,F8,STUB1,HSPB6,TP63,TRIM55,DVL1,CSRNP1,SOD1,KIF3B,APLP2,FECH,MAP4K4,CTGF,ITGA8,CA12,MKI67,EIF6,GSS,RAD23A,SGPL1,HMBS,RFNG,SV2B,CENPB,PTP4A3,DKC1,ROR1,NINJ1,SH3GL1,RTN4,ARHGAP35,B3GNT5,SETBP1,GSTP1,PPP1R3C,LRP6,HYOU1,FKBP1A,H2AFZ,ATP6AP1,MAFG,ENAH,LYZ,PHB,GJB2,SLC25A13,PPIF,TRIM28,CSRNP2,TIAL1,CASK,COPS3,GLIS2,SREBF1,USP22,BMF,NCAM1,NAB2,PNO1,RGMA,SLC31A1,PRPF19,PFN1,UBE2A,ARF1,CD4,MAP1B,SLC27A4,METAP2,CDON,PCYT2,ANXA7,GSK3B,C1QBP,RET,DSP,FERMT3,FST,PHB2,CD14,CLCN7,LFNG,SFRP2,ILF2,THBS1,ERBB4,HSPE1,EGLN3,SHANK2,MAPKAPK2,CALR,COL5A2,MAP3K1,VSIG4,CEBPB,PLXND1,PLCB4,EPHB3,GBE1,ADAM9,HLTF,RRM2B,CA5B,SLC35C1,MNAT1,SLC9A1,PTPRC,GATAD2A,EIF4G2,KIF1A,KEAP1,ATF4,STAM,MGAT1,UNG,LCP1,UXS1,CNR1,TPM3,FGFR2,DES,COX7A1,NDN,HAX1,NRBP1,PYGO2,CTSA,FSCN1,ATMIN,TFRC,SQSTM1,B3GAT3,ESR2,DEAF1,APOE,SLC4A2,GDF15,HS2ST1,HSPB8,COPS8,G6PC3,CETN2,ARF6,HSP90AB1,TNXB,ATP5J2,DAB2,SERPINA1,CSNK2B,NFE2L2,RPL4,TNFRSF1A,GNA12,DGAT2,THAP11,XIST,GRN,FOS,NTRK3,FLNC,SERPINH1,PPT1,EIF4A1,MBD3,PSAP,TPP1,ARHGDIA,BMPER,SIM1,BMP6,SGCD,ADRA1A,ICMT,TRAF3,DAD1,BAG3,TYMP,HSPA5,MRVI1,BIN1,CEBPG,CD28,CXCL14,HOXA7,STAB1,GCLM,PFKFB3,CNP,KCNK2,LAMA2,HNRNPAB,THRA,CITED1,KLF4,SLC3A2,DNAJC5,ADAM12,DUSP1,XRCC6,ALDH1A2,IGFBP3,CAPN2,H1F0,IRF8,MEGF8,RPSA,CD151,ATP6V0C,MSR1,PYCARD,PPIB,MLH1,VPS4A,HNRNPK,IRAK1,SLC19A3,SHC1,PSMG1,LIAS,RAD23B,WDR1,SLC20A1,VCAM1,CAPZB,EDNRB,TUBG1,NQO1,ZPR1,NFE2L1,SHB,CAPNS1,KIF5B,TTL,NR6A1,APOB,MAF,LDB3,NCSTN,HRAS,KPNA1,APRT,PEG10,ABR,ABCC1,TXN,WNT5B,CALCRL,CFL1,TKT,NR1H3,CPA3,PCK1,CCND2,VKORC1,BSG,CD68,STIP1,LRP8,MAP2K3,SFRP1,CYR61,FH,C3AR1,RPL24,SLC4A4,ADAM17,RALA,TCEA1,HMGN1,SP2,LIPA,GBA,TOP2A,STIM1,NACC1,PLOD3,IL11RA,PLAT,NDUFS4,RPS19,IMPDH2,ACTB,POMGNT1,APP,ITGB2,SUPV3L1,LAMP2,CLDN5,SREBF2,LIMS1,FKBP4,PRMT5,PEA15,FCER1G,NR5A2,CYCS,CBX4,DVL3,GABARAP,PLAU,PLP1,CXCL12,SDC4,TAF10,PAX5,CTBP1,NR2F1,ITGAV,CYBB,SLC7A5,SIAH2,CLCN3,RAD51C,KLF2,EIF2AK1,PTX3,SPP1,DNASE2,LMO4,SGCG,PSMC4,CDK6,CDK2AP1,TIE1,ADCYAP1R1,IL1RN,MAPK10,GNL3,STXBP5,VDAC1,TMOD1,LEP,EPB41L3,PDGFA,MMP14,PKM,RBBP8,SLC7A1,UGCG,CFTR,HIF1A,FAS,SOX17,HMOX1,FLNA,KCNMA1,EFNB1,ANXA1,F5,TGFB2,KIT,HSD11B2,HCST,UBA5,CTDNEP1,STK40,ALPL,PRNP,COX17,F13A1,GABBR1,NFASC,NFKBIZ,SLC5A3,CSF1R,NDUFA13,TNFAIP8L2,ITPA,LPAR1,PANK3,MMP9,SHMT2,CARM1	440	
Organismal Survival	morbidity or mortality	morbidity or mortality	1.99E-18	Decreased	-12.170	bias	 	NPM1,PCLO,ASS1,VAC14,C1QA,SPRY4,POR,GNB1,ATG9A,CCND3,CSE1L,GNA13,SURF1,PRKACA,CTSB,ATOX1,NHLH1,ADCYAP1,ACTG1,FTH1,USP18,PRDX1,BAG6,ADIPOQ,PPIA,HEXA,SMARCA4,LY6E,GNG5,AMOT,UCP2,MECOM,PVR,MARCKSL1,KIF7,CSF1,DERL1,SOX9,SOCS3,AKR1C3,GPC3,CTSD,HS6ST1,ABCB11,MTMR2,STXBP1,HDAC2,UROS,ASNA1,MAPK8IP2,FIG4,EIF4E2,TXNRD1,BCL2L1,AES,ADRA2A,RBX1,NAGLU,TFPI,UBE2I,SULF1,SUMO3,TFEB,F2RL3,PCDHGB4,EIF2S1,HLA-G,F8,STUB1,HSPB6,TP63,TRIM55,DVL1,CSRNP1,SOD1,KIF3B,APLP2,FECH,MAP4K4,CTGF,ITGA8,CA12,MKI67,EIF6,GSS,RAD23A,SGPL1,HMBS,RFNG,SV2B,CENPB,PTP4A3,DKC1,ROR1,NINJ1,SH3GL1,RTN4,ARHGAP35,B3GNT5,SETBP1,GSTP1,HLA-A,PPP1R3C,LRP6,HYOU1,FKBP1A,H2AFZ,ATP6AP1,MAFG,ENAH,LYZ,PHB,GJB2,SLC25A13,PPIF,TRIM28,CSRNP2,TIAL1,CASK,COPS3,GLIS2,SREBF1,USP22,BMF,NCAM1,NAB2,PNO1,RGMA,SLC31A1,PRPF19,PFN1,UBE2A,ARF1,CD4,MAP1B,SLC27A4,METAP2,CDON,PCYT2,ANXA7,GSK3B,C1QBP,RET,DSP,FERMT3,FST,PHB2,CD14,CLCN7,LFNG,SFRP2,ILF2,THBS1,ERBB4,HSPE1,EGLN3,SHANK2,MAPKAPK2,CALR,COL5A2,MAP3K1,VSIG4,CEBPB,PLXND1,PLCB4,EPHB3,GBE1,ADAM9,HLTF,RRM2B,CA5B,CTSG,SLC35C1,MNAT1,SLC9A1,PTPRC,GATAD2A,EIF4G2,KIF1A,KEAP1,ATF4,STAM,MGAT1,UNG,LCP1,UXS1,CNR1,TPM3,FGFR2,DES,COX7A1,NDN,HAX1,NRBP1,PYGO2,CTSA,FSCN1,ATMIN,TFRC,SQSTM1,B3GAT3,ESR2,DEAF1,APOE,SLC4A2,GDF15,HS2ST1,HSPB8,COPS8,G6PC3,CETN2,ARF6,HSP90AB1,TNXB,ATP5J2,DAB2,SERPINA1,CSNK2B,NFE2L2,RPL4,TNFRSF1A,GNA12,DGAT2,THAP11,XIST,GRN,FOS,NTRK3,FLNC,SERPINH1,PPT1,EIF4A1,MBD3,PSAP,TPP1,ARHGDIA,BMPER,SIM1,BMP6,SGCD,ADRA1A,ICMT,TRAF3,DAD1,BAG3,TYMP,HSPA5,MRVI1,BIN1,CEBPG,CD28,CXCL14,HOXA7,STAB1,GCLM,PFKFB3,CNP,KCNK2,LAMA2,HNRNPAB,THRA,CITED1,KLF4,SLC3A2,DNAJC5,ADAM12,DUSP1,XRCC6,ALDH1A2,IGFBP3,CAPN2,H1F0,IRF8,MEGF8,RPSA,CD151,ATP6V0C,MSR1,PYCARD,PPIB,MLH1,VPS4A,HNRNPK,IRAK1,SLC19A3,SHC1,PSMG1,LIAS,RAD23B,WDR1,SLC20A1,VCAM1,CAPZB,EDNRB,NPY1R,TUBG1,NQO1,ZPR1,NFE2L1,SHB,CAPNS1,KIF5B,TTL,NR6A1,APOB,MAF,LDB3,NCSTN,HRAS,KPNA1,APRT,PEG10,ABR,ABCC1,TXN,WNT5B,CALCRL,CFL1,TKT,NR1H3,CPA3,PCK1,CCND2,VKORC1,BSG,CD68,STIP1,LRP8,MAP2K3,SFRP1,CYR61,FH,C3AR1,RPL24,SLC4A4,ADAM17,RALA,TCEA1,HMGN1,SP2,LIPA,GBA,TOP2A,STIM1,NACC1,PLOD3,IL11RA,PLAT,NDUFS4,RPS19,IMPDH2,ACTB,POMGNT1,APP,ITGB2,SUPV3L1,LAMP2,CLDN5,SREBF2,LIMS1,FKBP4,PRMT5,PEA15,FCER1G,NR5A2,CYCS,CBX4,DVL3,GABARAP,PLAU,PLP1,CXCL12,SDC4,TAF10,PAX5,CTBP1,NR2F1,ITGAV,CYBB,SLC7A5,SIAH2,CLCN3,RAD51C,KLF2,EIF2AK1,PTX3,SPP1,DNASE2,LMO4,SGCG,PSMC4,CDK6,CDK2AP1,TIE1,ADCYAP1R1,IL1RN,MAPK10,GNL3,STXBP5,VDAC1,TMOD1,LEP,EPB41L3,PDGFA,MMP14,PKM,RBBP8,SLC7A1,UGCG,CFTR,HIF1A,FAS,SOX17,HMOX1,FLNA,KCNMA1,EFNB1,ANXA1,F5,TGFB2,KIT,HSD11B2,HCST,UBA5,CTDNEP1,STK40,ALPL,PRNP,COX17,F13A1,GABBR1,NFASC,NFKBIZ,SLC5A3,CSF1R,NDUFA13,TNFAIP8L2,ITPA,LPAR1,PANK3,MMP9,SHMT2,CARM1	443	
Cellular Movement	cell movement	cell movement	1.02E-17	Increased	5.406	bias	0.375	NPM1,PPP1R14B,SPRY4,GNB1,ATG9A,CSE1L,AIF1,GNA13,AHCY,ANXA2,RCC2,CTSB,PRKACA,ALCAM,PLTP,ADCYAP1,ELMO2,FTH1,FHL1,HTATIP2,GBP1,ARPC1B,PRDX1,DAPK2,ADIPOQ,PPIA,SMARCA4,SYNM,AMOT,UCP2,FCGR2A,ANOS1,IPO7,PVR,MYO5A,MARCKSL1,EDIL3,CSF1,WBP2,NR4A1,SOX9,SOCS3,SEPT9,RABEP1,GPC3,TUBA1C,FYB,SMPD2,BCL2L1,ADRA2A,TFPI,TNS1,ETV5,UBE2I,PEBP1,IGFBP4,SULF1,LITAF,F2RL3,PLGRKT,FAT3,HLA-G,PSMD10,STUB1,IGSF8,LASP1,TP63,SOD1,APLP2,MAP4K4,RAP2B,CTGF,ITGA8,BBS1,SGPL1,LGMN,PTP4A2,AFAP1,KLF8,ZBTB16,BIRC7,PTP4A3,HMGA1,JUNB,ROR1,NINJ1,RTN4,ARHGAP35,HLA-A,NQO2,LRP6,HYOU1,RUVBL1,SDC3,ASNS,CDH11,ENAH,LYZ,CES1,PHB,RHOD,GJB2,MYL12A,CD209,PLXNA1,PTPRK,PPIF,EGR1,GLIS2,SREBF1,TREM2,NCAM1,NAB2,PLCB2,PFN1,ARF1,CD4,UNC5B,MAP1B,CD63,CAMK2D,C1QBP,GPC1,GSK3B,RET,FERMT3,FST,GSDMB,PHB2,DGKE,TARS,TPSAB1/TPSB2,CDC42,MAPT,SH2B3,CD14,SFRP2,CLCN4,DKK3,THBS1,DUSP10,ERBB4,CYGB,EGLN3,MAPKAPK2,CALR,TPST2,BHLHE41,MAP3K1,HYAL1,CEBPB,PLXND1,ASAP2,NUCB2,EPHB3,C6,NCKAP1L,CPEB1,ADAM9,WHSC1,CTSG,NEXN,SLC9A1,PTPRC,SRPX2,LTF,KEAP1,ST6GALNAC2,LMX1A,TMSB10/TMSB4X,GNG12,LCP1,CNR1,TMEM201,FLOT1,TPM3,FGFR2,NDN,HAX1,FSCN1,BTG2,GAPDH,DUSP4,SQSTM1,ESR2,APOE,NME1,SLC4A2,OSGIN1,PHLDA2,GDF15,LGALS9,PROX1,G6PC3,GRINA,ARF6,ACTR3,HSP90AB1,DAB2,SERPINA1,CSNK2B,NFE2L2,P4HA2,S100A1,TNFRSF1A,GNA12,ALOX5AP,SNCG,GRN,FOS,MT-ND1,MYOC,NTRK3,FLNC,SERPINH1,ARHGDIA,BMP6,USP5,MBP,ACO2,RACK1,NME2,BAG3,TYMP,HSPA5,CD28,RHOG,CXCL14,HOXA7,STAB1,CDC42EP1,PEX7,CNP,KCNK2,LAMA2,HNRNPAB,THRA,CAPG,RAPGEF3,KLF4,SLC3A2,FOSB,SDCBP,ADAM12,DUSP1,MATN2,LIMA1,IGFBP3,CAPN2,IRF8,SIRPA,RPSA,CD151,MSR1,PYCARD,PPIB,HNRNPK,SHC1,SAA1,MCAM,RHOBTB2,RNH1,VCAM1,EDNRB,NQO1,ST3GAL6,MGAT5,EMD,TRPA1,HSPD1,FGF1,SERPINE2,CXCL16,CAPNS1,KIF5B,CHI3L1,APOB,MARK1,HRAS,CHST2,BCAT1,DGCR6L,CTSS,ABR,ABCC1,TXN,WNT5B,CALCRL,CFL1,TKT,BSG,NR1D1,YARS,MS4A4A,IL10RA,ALDOA,LRP8,MAP2K3,SFRP1,FH,CYR61,C3AR1,ALK,S100A11,ADAM17,RALA,DUSP6,CTNNA1,DCLK1,LIPA,GBA,SRGAP1,ANXA5,PRKCE,STIM1,SARS,IL11RA,PLAT,RPS19,TYROBP,ACTB,CYP1B1,APP,ITGB2,LIMS1,DOCK8,FKBP4,PRMT5,FCER1G,P2RY12,TSPO,PLAU,RUFY3,GAB2,PLP1,VPS28,PTPN23,CMA1,CXCL12,SDC4,TUBB,MTCH2,CTBP1,NR2F1,NARS,ITGAV,CYBB,NEO1,SIAH2,CLCN3,KLF2,PTX3,IGFBP6,SPP1,LMO4,GCNT2,CDK6,PKN1,LMCD1,TIE1,EFS,IL1RN,MAPK10,UHMK1,AKR1B1,RPL13A,LEP,PDGFA,MMP14,PKM,CFTR,HIF1A,FAS,TNFRSF12A,TACR1,HMOX1,CCDC88A,PARK7,KCNMA1,FLNA,CSPG4,EFNB1,ANXA1,TGFB2,KIT,SEMA3B,NDUFAF3,PRNP,SEMA3E,F13A1,NFKBIZ,CSF1R,ENO1,WARS,TNFAIP8L2,LPAR1,SLC16A1,MMP9	398	
Cellular Movement	migration	migration of cells	2.34E-17	Increased	5.499	bias	0.718	NPM1,WHSC1,CTSG,NEXN,SLC9A1,PPP1R14B,SPRY4,PTPRC,SRPX2,ATG9A,LTF,CSE1L,KEAP1,GNA13,LMX1A,AIF1,TMSB10/TMSB4X,GNG12,AHCY,LCP1,CNR1,TMEM201,FGFR2,TPM3,FLOT1,ANXA2,NDN,HAX1,RCC2,FSCN1,BTG2,PRKACA,CTSB,ALCAM,DUSP4,PLTP,ELMO2,ADCYAP1,ESR2,FTH1,APOE,NME1,HTATIP2,FHL1,SLC4A2,PHLDA2,OSGIN1,DAPK2,PRDX1,GDF15,ADIPOQ,LGALS9,PPIA,PROX1,SMARCA4,G6PC3,GRINA,SYNM,ARF6,ACTR3,HSP90AB1,DAB2,SERPINA1,CSNK2B,AMOT,NFE2L2,P4HA2,UCP2,TNFRSF1A,FCGR2A,GNA12,ALOX5AP,IPO7,SNCG,PVR,GRN,FOS,MARCKSL1,MT-ND1,EDIL3,MYOC,NTRK3,FLNC,CSF1,NR4A1,WBP2,ARHGDIA,SOX9,BMP6,SOCS3,SEPT9,USP5,RABEP1,RACK1,BAG3,NME2,HSPA5,GPC3,CD28,RHOG,CXCL14,HOXA7,STAB1,CDC42EP1,PEX7,LAMA2,KCNK2,CNP,RAPGEF3,CAPG,THRA,FYB,SMPD2,KLF4,SLC3A2,BCL2L1,SDCBP,ADRA2A,ADAM12,MATN2,DUSP1,LIMA1,IGFBP3,CAPN2,TFPI,TNS1,SIRPA,UBE2I,RPSA,ETV5,CD151,SULF1,IGFBP4,LITAF,F2RL3,MSR1,PPIB,PLGRKT,PYCARD,FAT3,HNRNPK,HLA-G,SHC1,PSMD10,STUB1,MCAM,SAA1,RNH1,RHOBTB2,IGSF8,LASP1,VCAM1,TP63,EDNRB,NQO1,MGAT5,ST3GAL6,TRPA1,SOD1,HSPD1,FGF1,SERPINE2,CXCL16,APLP2,CAPNS1,CHI3L1,MAP4K4,RAP2B,CTGF,APOB,ITGA8,MARK1,HRAS,BBS1,CHST2,BCAT1,SGPL1,DGCR6L,LGMN,PTP4A2,ABR,CTSS,ABCC1,AFAP1,TXN,ZBTB16,WNT5B,BIRC7,CALCRL,CFL1,PTP4A3,ROR1,NINJ1,NR1D1,BSG,YARS,MS4A4A,IL10RA,RTN4,ALDOA,ARHGAP35,MAP2K3,LRP8,SFRP1,CYR61,FH,C3AR1,ALK,S100A11,ADAM17,RALA,HLA-A,NQO2,DUSP6,LRP6,CTNNA1,HYOU1,RUVBL1,SDC3,ASNS,DCLK1,CDH11,ENAH,LIPA,LYZ,CES1,GBA,PHB,RHOD,SRGAP1,ANXA5,PRKCE,STIM1,SARS,GJB2,MYL12A,PLAT,IL11RA,RPS19,PLXNA1,CD209,PTPRK,PPIF,TYROBP,ACTB,EGR1,CYP1B1,APP,ITGB2,GLIS2,DOCK8,SREBF1,TREM2,FCER1G,FKBP4,PRMT5,TSPO,P2RY12,PLAU,RUFY3,NCAM1,NAB2,GAB2,PLCB2,PLP1,PFN1,VPS28,ARF1,CMA1,CD4,MAP1B,UNC5B,CXCL12,SDC4,CD63,NR2F1,CTBP1,NARS,CAMK2D,CYBB,ITGAV,NEO1,SIAH2,GSK3B,GPC1,C1QBP,RET,CLCN3,KLF2,FERMT3,PTX3,IGFBP6,SPP1,LMO4,GCNT2,CDK6,PHB2,DGKE,TARS,PKN1,TPSAB1/TPSB2,TIE1,LMCD1,EFS,CDC42,IL1RN,SH2B3,MAPT,MAPK10,CD14,UHMK1,RPL13A,LEP,SFRP2,PDGFA,MMP14,PKM,CFTR,HIF1A,FAS,TNFRSF12A,CLCN4,TACR1,HMOX1,CCDC88A,PARK7,CSPG4,THBS1,FLNA,KCNMA1,ANXA1,EFNB1,ERBB4,DUSP10,TGFB2,KIT,EGLN3,CYGB,MAPKAPK2,PRNP,NDUFAF3,SEMA3E,CALR,BHLHE41,MAP3K1,HYAL1,F13A1,CEBPB,NFKBIZ,CSF1R,PLXND1,WARS,TNFAIP8L2,LPAR1,SLC16A1,ASAP2,EPHB3,NUCB2,C6,CPEB1,NCKAP1L,ADAM9,MMP9	363	
Neurological Disease, Psychological Disorders	disorder of basal ganglia	disorder of basal ganglia	2.65E-17	Decreased	-2.600	bias	-1.670	TUBA1B,NPM1,CTGF,AHCYL1,RAN,CA12,HRAS,PCDH7,GHITM,GNB1,LTF,CSE1L,CTSS,HADHB,PNKD,SYPL1,ATF4,CHCHD2,TXN,ZBTB16,AHCY,PPP1R1B,CNR1,TUBB2A,TPM3,FLOT1,ANXA2,JUNB,ELOVL1,RASL12,RPH3A,NGRN,HSPA8,NR1D1,CD68,RTN4,GAPDH,SCN11A,GSTP1,FTH1,EIF3K,SORL1,APOE,NME1,RPS3A,DDIT3,GBP1,NQO2,HMGN1,PPIA,KAZN,UCHL1,CETN2,GBA,MAL2,SCN3A,SERPINA1,NFE2L2,RPL31,MYL12A,PLOD2,TNFRSF1A,TUBB4B,MLF2,ACTB,EGR1,RPL17,TRIB3,SNCG,PSMB6,ARL3,APP,MYO5A,FOS,FTL,MT-ND1,PSME1,LAMP2,UQCR10,SEPHS1,NR4A1,FKBP4,TSPO,CYCS,SOX9,ID4,ADRA1A,EEF1A1,PFN1,PFKFB1,ARL6IP5,MBP,MAP1B,SCN7A,ATP5L,MT1M,SDC4,DYNLT1,HSPA5,CERS2,FAM173A,AK1,SLC25A6,RHOG,RPL13,STRN4,COMT,LYNX1,TUBA1C,GSK3B,NDUFA8,SPP1,GAS5,GPS2,KCNK2,CNP,ATP6V1A,LMCD1,FOSB,BCL2L1,ADRA2A,XRCC6,MAPT,RARRES3,RPL13A,MT-TP,RPSA,ETV5,PEBP1,SCD,SRM,SUMO3,COX7B,LEP,SLC1A4,SRPX,HIGD1A,PKM,COPE,UGCG,ALAS1,NDUFA2,FARSB,HMOX1,SLC19A3,HINT1,PARK7,PREPL,STUB1,DKK3,PPP1R2,MICALL1,CRYM,ATP13A2,PRNP,PSAT1,ADCY2,MT-ATP6,CAPZB,TUBG1,DNAJC1,SOD1,TSN,NDUFA13,ATP6V1E1,P4HA1,MT-ND5,KCTD13,CAPNS1,CYC1,UQCRC1,CHI3L1,ATP6V1B2	173	
Cell Death and Survival	apoptosis	apoptosis of tumor cell lines	1.26E-16	Decreased	-3.450	 	-2.866	CSTA,NPM1,PSG2,WHSC1,CTSG,TMBIM6,SLC9A1,ODC1,PTPRC,EIF4G2,CCND3,CSE1L,ATF4,TMSB10/TMSB4X,LAIR1,PPP1R1B,CNR1,FGFR2,ANXA2,NDN,HAX1,HSPA8,BTG2,GPR65,PRKACA,ATMIN,CTSB,GAPDH,TFRC,ALCAM,DUSP4,SQSTM1,ESR2,FTH1,APOE,NME1,HTATIP2,USP18,DDIT3,DAPK2,OSGIN1,PRDX1,BAG6,GDF15,ADIPOQ,HSPB8,LGALS9,PPIA,CCT4,OGT,RABL6,HSP90AB1,DAB2,NFE2L2,MECOM,TNFRSF1A,SLC39A6,GRN,FOS,NTRK3,NR4A1,PSAP,ARHGDIA,SOX9,BMP6,SOCS3,ACO2,RACK1,BAG3,OGFOD1,TYMP,RNASE1,DNAJC15,CBX5,HSPA5,CD28,CTSD,HSPA4,SAE1,ENTPD5,PACS2,NUPR1,HOXA7,BCAS2,HDAC2,PTPRQ,PPP1R11,THRA,SDHC,KLF4,TXNRD1,FOSB,BCL2L1,DUSP1,TXN2,RBX1,IGFBP3,CAPN2,IRF8,SIRPA,PEBP1,SULF1,IGFBP4,SCD,TFEB,MSR1,SRPX,PYCARD,HNRNPK,MLH1,IRAK1,HLA-G,SHC1,STUB1,RHOBTB2,RPS3,RAD23B,SEC61G,TP63,DVL1,NQO1,SOD1,HSPD1,NFE2L1,KIFC3,CAPNS1,COX5A,SLC25A5,RPLP0,CTGF,COX8A,HRAS,DYNLL1,AHSA1,ABCC1,TXN,ZBTB16,BIRC7,CAPN6,CENPB,STOML2,HMGA1,JUNB,ROR1,RTN4,MAP2K3,SFRP1,CYR61,GSTP1,PHLPP1,ALK,S100A11,ADAM17,RAB32,KAZN,CCAR2,ASNS,PRAF2,UCHL1,ACSM5,PHB,TOP2A,PRKCE,STIM1,NACC1,FKBP5,SMPD3,ACVR1C,RPS24,PLAT,WSB1,RPS19,TRIM28,EGR1,CYP1B1,APP,IMMT,SREBF1,LIMS1,USP22,BMF,PRMT5,PEA15,CYCS,PLAU,NCAM1,PRPF19,CD4,UNC5B,CXCL12,VDAC2,CTBP1,G0S2,CDON,ITGAV,SIAH2,GSK3B,RET,KLF2,IGFBP6,SPP1,FST,GPS2,LMO4,HSPA9,PHB2,CDK6,PKN1,PPP2R1A,CDC42,MAPT,MAPK10,NUAK1,VDAC1,PHF1,AKR1B1,SFRP2,LEP,GEM,MMP14,PKM,UGCG,HIF1A,FAS,HMOX1,HINT1,PARK7,DKK3,THBS1,CSPG4,ERBB4,TGFB2,KIT,TCP1,SEMA3B,HCST,PRNP,CALR,TAF6,MAP3K1,HYAL1,CEBPB,NFKBIZ,CSF1R,NDUFA13,FAU,ENO1,MAT2A,MMP9	249	
Cancer, Organismal Injury and Abnormalities	benign neoplasia	benign neoplasia	3.74E-16	 	-0.424	bias	0.959	TWF1,RPE,ASS1,COL8A1,NPAS2,ODC1,POR,CCND3,KEAP1,UNG,ALDOC,SLC2A5,ALDH1B1,PLD3,MFAP5,CNR1,FGFR2,ANXA2,NDN,PLAG1,MRPL17,PRKACA,CTSB,ALCAM,ESR2,FTH1,APOE,HTATIP2,DDIT3,PHLDA2,PRDX1,HN1,CUBN,ARL4C,ADIPOQ,COL15A1,SMARCA4,COL16A1,HSP90AB1,DAB2,NFE2L2,RPN1,MECOM,TNFRSF1A,DGAT2,TRIB3,FOS,AFF3,ATP6V1F,NTRK3,CSF1,NR4A1,SOX9,BMP6,ID4,ADRA1A,SOCS3,MEGF9,NTMT1,SCN7A,RNASE1,CES2,MRVI1,CEBPG,RHOG,ENTPD5,CXCL14,STAB1,ERAL1,CNP,RAPGEF3,THRA,SDHC,BCL2L1,KCNG1,ADAM12,ADRA2A,DUSP1,CDH20,ALDH1A2,IGFBP3,TMEM176B,UBE2I,IGFBP4,SCD,CARS,SCARA5,MLH1,SHC1,COL6A1,MCAM,PSAT1,VCAM1,TP63,EDNRB,NQO1,DVL1,MGAT5,SERPINE2,RPS15,SLC33A1,RAP2B,NR6A1,AHCYL1,MAF,CA12,HRAS,MKI67,ADGRL1,ZBTB7B,WNT5B,CAPN6,CALCRL,SLC24A3,DKC1,TUBB2A,PCK1,HMGA1,AP2S1,INPP4B,CCND2,GLUL,ARHGAP35,ALDOA,LRP8,SFRP1,CYR61,FH,SETBP1,GSTP1,ALK,SLC4A4,S100A11,GSTM5,UQCRH,HLA-A,PAM16,HMGN1,LRP6,CTNNA1,FKBP1A,RUVBL1,DCLK1,FANCE,CADM2,ANXA5,TOP2A,PRKCE,TPO,MYH1,CCDC68,RPS19,EGR1,STXBP6,CYP1B1,APP,COL5A3,SLC48A1,PRMT5,PEA15,NR5A2,CLUH,NCAM1,PLP1,KCND3,CXCL12,PAX5,NR2F1,PLCE1,RPL19,SLC7A5,ANXA7,GSK3B,RET,COL27A1,SPP1,TBC1D2B,RPL9,PPP2R1A,ADCYAP1R1,SH2B3,LEP,EPB41L3,PRDX5,MMP14,PKM,RBBP8,SLC7A1,UGCG,HIF1A,FAS,TNFRSF12A,HMOX1,HINT1,PARK7,THBS1,ERBB4,ANXA1,KIT,HSD11B2,MICALL1,ARHGEF2,ASAP3,CALR,COL5A2,DLGAP4,RNF43,MAP3K1,HYAL1,VSIG4,GABBR1,NFKBIZ,SLC5A3,CSF1R,C2orf88,PLCB4,ITPA,LPAR1,PAG1,EPHB3,CLDN2,MMP9,ATP6V1B2	223	
Neurological Disease	movement disorder	Movement Disorders	1.40E-15	Decreased	-5.085	bias	 	NPM1,CA5B,SLC9A1,GNB1,LTF,CSE1L,GLB1,SYPL1,ATF4,AHCY,PPP1R1B,CNR1,FLOT1,TPM3,ANXA2,RPH3A,RASL12,HSPA8,CTSA,CTSB,GAPDH,SQSTM1,SCN11A,EIF3K,FTH1,ABHD12,APOE,NME1,USP18,SLC4A2,GBP1,DDIT3,PPIA,HEXA,CETN2,MAL2,SERPINA1,BCAP31,NFE2L2,PLOD2,SIGMAR1,TUBB4B,MLF2,TNFRSF1A,TRIB3,SNCG,PSMB6,CSTB,MYO5A,FOS,MT-ND1,NTRK3,PPT1,SEPHS1,NR4A1,PSAP,TPP1,SOX9,ID4,ADRA1A,EEF1A1,ARL6IP5,MBP,SCN7A,MT1M,HSPA5,CTSD,AK1,RHOG,STRN4,MTMR2,TUBA1C,NDUFA8,GAS5,CNP,KCNK2,MAPK8IP2,LAMA2,ARSA,FOSB,BCL2L1,DNAJC5,ADRA2A,XRCC6,TMEM176B,ETV5,RPSA,PEBP1,SUMO3,SCD,SLC1A4,SRPX,COPE,ALAS1,NDUFA2,FARSB,PREPL,STUB1,PPP1R2,CRYM,ATP13A2,PSAT1,MT-ATP6,CAPZB,TUBG1,DNAJC1,SOD1,TSN,ATP6V1E1,KCTD13,APLP2,CAPNS1,TTL,CHI3L1,TUBA1B,JMJD8,CTGF,AHCYL1,CA12,RAN,PCDH7,HRAS,GHITM,CTSS,GAA,HADHB,PNKD,CHCHD2,TXN,ZBTB16,TUBB2A,ELOVL1,JUNB,NINJ1,NGRN,NR1D1,CD68,MBD4,RTN4,LRP8,GSTP1,SORL1,RPS3A,NQO2,HMGN1,KAZN,FKBP1A,UCHL1,GBA,SCN3A,RPL31,MYL12A,NDUFS4,EGR1,ACTB,RPL17,ARL3,APP,FTL,PSME1,LAMP2,UQCR10,FKBP4,ATXN10,TSPO,CYCS,NCAM1,NAB2,PLP1,PFN1,KCND3,PFKFB1,MAP1B,ATP5L,SDC4,DYNLT1,FAM173A,SLC25A6,RPL13,COMT,GSK3B,CLCN3,SPP1,GPS2,SGCG,ATP6V1A,LMCD1,MAPT,RARRES3,RPL13A,MT-TP,SRM,COX7B,LEP,EPB41L3,HIGD1A,KLRD1,PKM,UGCG,CFTR,FAS,HMOX1,HINT1,PARK7,KCNMA1,DKK3,PHYH,MICALL1,PRNP,ADCY2,GABBR1,NDUFA13,P4HA1,PLCB4,MT-ND5,ITPA,CYC1,UQCRC1,MMP9,ATP6V1B2	220	
Protein Degradation, Protein Synthesis	catabolism	catabolism of protein	8.70E-15	Increased	2.705	bias	0.381	NPM1,CSTA,SPCS1,CTSG,SH3GLB1,NCSTN,ODC1,RAD23A,SNX12,PTPRC,LGMN,CTSS,GPR26,CLN6,NR1H3,CPA3,JUNB,FBXO8,HSPA8,CTSA,CTSB,GAPDH,CCT3,SFRP1,SQSTM1,SORL1,APOE,ADAM17,USP18,BAG6,DPM2,ADIPOQ,CCAR2,UCHL1,CCT4,OGT,GBA,PHB,FBXW11,UBE2K,AAK1,PSMD14,SERPINA1,AMFR,PLAT,STT3B,ADRM1,CSTB,RNF6,PSMD8,COPG1,APP,LAMP2,CSF1,SREBF1,DERL1,CCT7,TPP1,DVL3,SOX9,PLAU,SOCS3,TRAF3,PFN1,VPS28,CMA1,BAG3,SDC4,HSPA5,GPC3,CTSD,CNDP2,DPP3,IFI30,CCT5,SIAH2,GSK3B,DPM3,CHMP1A,VPS11,STXBP1,PSMB5,HDAC2,PSMF1,PHB2,PSMC4,AURKAIP1,SEL1L,BCL2L1,UBE2D2,ADAM12,IL1RN,EDEM1,NAGLU,CAPN2,UBE2E1,UBE2I,RNPEP,CREBL2,UBXN1,RNF165,PPIB,PYCARD,MMP14,CFTR,STXBP4,VPS4A,FAS,SOX17,NLK,PARK7,F8,STUB1,CSPG4,FLNA,F5,TRABD2A,TCP1,OAZ1,LONP1,ATP13A2,CALR,DVL1,RAB7A,DNAJC1,SOD1,HSPD1,PSME3,NDUFA13,SERPINE2,CAPNS1,PSMD2,ADAM9,MMP9	134	
Dermatological Diseases and Conditions	psoriasis	chronic psoriasis	2.32E-14	 	 	 	 	S100A11,APOE,SRM,TWF1,PSMB10,SEC23B,PKM,GARS,ME1,HIF1A,TAF10,EIF2S1,H2AFZ,IRAK1,METAP2,POR,HMOX1,PGD,PHB,TNXB,PGAM1,ALDH3A2,EIF5,HSPE1,CCT5,ETF1,UQCRFS1,GOT1,C1QBP,GJB2,PPIF,HSPH1,TUBG1,SLC39A6,CEBPB,EIF2S2,CSTB,HSPA8,FSCN1,CTSB,MAP2K3,ATOX1,EIF5A,SLC25A5,PCBD1,GSTP1,UBE2I	47	
Cellular Movement	cellular infiltration	cellular infiltration	6.10E-14	 	-0.172	 	-1.029	NPM1,CTGF,CTSG,HRAS,LTF,CTSS,ZBTB16,CNR1,TKT,JUNB,NINJ1,CTSB,GAPDH,ALDOA,PLTP,SFRP1,CYR61,ESR2,C3AR1,APOE,ADAM17,GBP1,HLA-A,PRDX1,NQO2,ADIPOQ,HYOU1,PPIA,CES1,GBA,SERPINA1,STIM1,NFE2L2,GJB2,IL11RA,PLAT,UCP2,TNFRSF1A,ACTB,ALOX5AP,APP,ITGB2,EDIL3,GLIS2,SREBF1,CSF1,FCER1G,NR4A1,PLAU,SOCS3,PLCB2,PLP1,CD4,MBP,CMA1,ACO2,UNC5B,CXCL12,TUBB,HSPA5,CD28,CYBB,PTX3,FST,SPP1,CNP,KCNK2,HNRNPAB,EFS,DUSP1,IL1RN,IGFBP3,CD14,IRF8,AKR1B1,RPL13A,LEP,MSR1,PDGFA,MMP14,CFTR,HIF1A,FAS,TACR1,HMOX1,CCDC88A,THBS1,DUSP10,SAA1,MCAM,ANXA1,EGLN3,MAPKAPK2,SEMA3E,VCAM1,NQO1,HYAL1,MGAT5,TRPA1,HSPD1,NFKBIZ,CSF1R,ENO1,CXCL16,TNFAIP8L2,C6,MMP9	107	
Dermatological Diseases and Conditions	psoriasis	psoriasis	1.01E-13	 	 	 	 	CSTA,TWF1,RAN,GARS,MKI67,EIF6,ODC1,MUC7,POR,SCO2,PTPRC,LTF,CCND3,CTSS,ABCC1,RAB38,KEAP1,ETF1,ZBTB16,CFL1,FGFR2,ANXA2,JUNB,HAX1,HSPA8,CCND2,FSCN1,CTSB,GAPDH,MAP2K3,ATOX1,PCBD1,C3AR1,GSTP1,EPHX1,S100A11,APOE,ADAM17,GBP1,ARPC1B,PSMB10,PPP1R3C,SEC23B,CRAT,FKBP1A,PROX1,H2AFZ,GBA,PHB,TNXB,PGAM1,UBE2K,GJB2,PLAT,OAS1,PPIF,EGR1,SLC39A6,PSMB6,CSTB,CYP1B1,FOS,ITGB2,PSAP,CYCS,ARHGDIA,PLAU,ID4,EEF1A1,CD4,MBP,TYMP,TAF10,HSPA5,TUBB,CD63,METAP2,PGD,G0S2,ALDH3A2,EIF5,FAR2,IFI30,CCT5,UQCRFS1,GOT1,C1QBP,YWHAB,GM2A,LAMA2,EIF2S2,PKN1,BCL2L1,ADAM12,DUSP1,IL1RN,ATP6V0D1,IGFBP3,EIF5A,VDAC1,CBX3,UBE2I,SRM,MMP14,PKM,EPSTI1,HIF1A,ME1,EIF2S1,IRAK1,HLA-G,SHC1,HMOX1,CSPG4,ANXA1,MCAM,HSPE1,PSMA3,CALR,SEC61G,VCAM1,HSPH1,TUBG1,F13A1,CEBPB,IL20RB,THRSP,SLC16A1,APOC1,SLC25A5,MMP9	131	
Protein Synthesis	synthesis	synthesis of protein	3.99E-13	 	1.318	 	0.515	NPM1,EIF6,PTPRC,EIF4G2,ETF1,ATF4,NANOS1,DKC1,JUNB,MTPN,MRPL17,STIP1,BTG2,GAPDH,MAP2K3,PLTP,RPL41,PHLPP1,EIF3K,RPL24,RPS3A,DDIT3,ADIPOQ,HSPB8,FKBP1A,H2AFZ,SARS,RPS5,SMPD3,MT-TD,RPS24,MT-TY,RPL17,CPEB4,CYP1B1,APP,EIF3G,FOS,MRPL51,MRPS7,SREBF1,CSF1,FAM129A,EIF4A1,RPL37,MT-RNR1,GAB2,EEF1A1,CD4,RACK1,OGFOD1,MRM2,HSPA5,METAP2,PABPC4,EIF5,RPL19,GPC1,KLF2,EIF2AK1,FST,SPP1,MT-TC,EIF2B3,RAPGEF3,EIF4E2,MARS,EPRS,MAPT,IGFBP3,EIF5A,CNBP,RPL13A,PPAT,MT-TP,LEP,MMP14,SLC7A1,EIF2S1,MT-TN,FAS,HNRNPK,FARSB,PARK7,THBS1,PPP1R2,ANXA1,MT-TS1,ARHGEF2,RPS3,PRNP,PATL1,CALR,TP63,RPL30,DNAJC1,SOD1,MKNK2,RPS29,RPS4Y1,WARS,RPS27L,CPEB1,RPL38	104	
Cell Death and Survival	survival	cell survival	4.35E-13	Increased	7.319	bias	1.257	WHSC1,ASS1,RRM2B,SLC9A1,ODC1,POR,PTPRC,IP6K3,LTF,CSE1L,KIF1A,KEAP1,MCOLN3,ATF4,STAM,UNG,MFAP5,PPP1R1B,FGFR2,NPY5R,BTG2,PRKACA,PSMA4,CTSB,ALCAM,SQSTM1,ADCYAP1,ESR2,FTH1,APOE,NME1,HTATIP2,DDIT3,GDF15,ADIPOQ,HSPB8,PPIA,SMARCA4,SYNM,OGT,HSP90AB1,DAB2,BCAP31,ALPK2,NFE2L2,SIGMAR1,UCP2,MECOM,TNFRSF1A,POLDIP2,FOS,NTRK3,CSF1,EIF4A1,NR4A1,PSAP,SOX9,ABCC3,BMP6,ID4,SOCS3,TRAF3,PCDH18,SEPT9,MBP,RACK1,BAG3,TYMP,HSPA5,GPC3,CD28,HSPA4,PACS2,NUPR1,SNRPD1,PSMB5,HDAC2,PFDN5,AURKAIP1,RAPGEF3,PPP1R11,KLF4,BCL2L1,DUSP1,XRCC6,IGFBP3,CAPN2,TFPI,PPAT,UBE2I,RPSA,ETV5,SULF1,SCD,TFEB,CARS,MSR1,PYCARD,PPIB,PCDHGB4,LEO1,EIF2S1,MLH1,IRAK1,HLA-G,SHC1,MED15,MCAM,ATP13A2,HSPB6,VCAM1,TP63,USMG5,NPY1R,MGAT5,SOD1,HSPD1,PSME3,FGF1,KIFC3,CHI3L1,APOB,CTGF,HRAS,NCSTN,ABCC6,SGPL1,PTP4A2,ABCC1,TXN,BIRC7,PTP4A3,PDRG1,ELOVL1,HMGA1,ROR1,VKORC1,MBD4,SFRP1,TCF7,CYR61,FH,GSTP1,PHLPP1,ALK,ADAM17,ATP5H,UBQLN1,DUSP6,HMGN1,HYOU1,KAZN,ASNS,UCHL1,LYZ,BANF1,PHB,ANXA5,TOP2A,PRKCE,NACC1,FKBP5,PLAT,IL11RA,PTPRK,TYROBP,TRIM28,EGR1,CASK,APP,ITGB2,SREBF2,LIMS1,PPP1R16B,DOCK8,FCER1G,PEA15,PLAU,NCAM1,GAB2,PRPF19,SLC31A1,PLP1,PTPN23,CCNI,CD4,UNC5B,CXCL12,TUBB,METAP2,CTBP1,CAMK2D,PLCE1,DPP3,ITGAV,CYBB,POMP,GSK3B,GPC1,RET,BCKDK,RAD51C,KLF2,SLC6A8,SPP1,ANLN,PHB2,PSMC4,CDK6,CDK2AP1,TIE1,SEL1L,OSTM1,PPP2R1A,CDC42,IL1RN,MAPT,MAPK10,RARRES3,NUAK1,VDAC1,LEP,SFRP2,ATF5,PDGFA,PKM,UGCG,SLC7A1,HIF1A,FAS,CLCN4,HMOX1,HINT1,NLK,PARK7,FLNA,THBS1,DUSP10,ERBB4,EFNB1,TGFB2,KIT,TCP1,EGLN3,PSMA3,SELENOH,MAPKAPK2,PRNP,CALR,MAP3K1,GABBR1,CEBPB,CSF1R,NDUFA13,THRSP,EMP1,ENO1,SLC16A1,EPHB3,PPP2R1B,MMP9,SHMT2,RPL38	263	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of osteosarcoma cells	5.91E-13	Decreased	-6.325	bias	 	EEF1A1,PNO1,RAN,RPL7A,RPS11,VDAC2,RPL35,RPL13,RPS13,CSE1L,RPL19,SNRPD1,PSMA3,SNRPD3,RPS12,RPS3,RPS5,RPL31,RPS24,RPS19,CAPN6,PSMB5,HSPA9,PSMC4,RPS21,RPL37A,RPS29,RPL9,FAU,COPG1,EIF3G,RPS4Y1,RPS16,PSMA5,PSMA4,RPL37,EBNA1BP2,RPL13A,RPLP0,RPL38,UBE2I	41	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of myeloid cells	6.47E-13	 	1.999	bias	-0.996	NPM1,CTGF,CTSG,HRAS,PTPRC,LTF,CTSS,TXN,AIF1,TMSB10/TMSB4X,CNR1,FLOT1,ANXA2,NINJ1,YARS,MS4A4A,RTN4,CTSB,PLTP,SFRP1,CYR61,ADCYAP1,C3AR1,APOE,ADAM17,DAPK2,NQO2,GDF15,ADIPOQ,LGALS9,PPIA,G6PC3,LIPA,CES1,GBA,SERPINA1,STIM1,NFE2L2,GJB2,PLAT,RPS19,TYROBP,TNFRSF1A,FCGR2A,ALOX5AP,PVR,APP,GRN,ITGB2,MT-ND1,EDIL3,GLIS2,SREBF1,CSF1,TREM2,FCER1G,NR4A1,PLAU,NAB2,SOCS3,PLCB2,PLP1,PFN1,CD4,CMA1,UNC5B,CXCL12,CD28,CXCL14,ITGAV,CYBB,STAB1,NEO1,C1QBP,PTX3,SPP1,CNP,CAPG,TPSAB1/TPSB2,CDC42,DUSP1,IL1RN,SH2B3,IGFBP3,CD14,SIRPA,RPL13A,CD151,LITAF,LEP,MSR1,MMP14,CFTR,HIF1A,FAS,TACR1,HMOX1,CCDC88A,FLNA,THBS1,ANXA1,MCAM,DUSP10,SAA1,EFNB1,TGFB2,KIT,EGLN3,MAPKAPK2,PRNP,SEMA3E,VCAM1,EDNRB,NQO1,HYAL1,MGAT5,NFKBIZ,PLXND1,CSF1R,TNFAIP8L2,C6,NCKAP1L,MMP9	123	
Cardiovascular Disease	peripheral arterial disease	peripheral arterial disease	7.00E-13	 	 	 	 	RAP2B,ADAMTS8,BAG3,MARK1,CXCL12,VWA5A,CECR1,HSPA4,CTSS,PLEKHO2,IFI30,GULP1,LCP1,SPP1,TBC1D2B,LAIR1,POLR2K,CAPG,FYB,KLF4,RPL9,NGRN,LMCD1,CTSA,BTG2,CTSB,EBNA1BP2,IRF8,PLTP,C3AR1,TMEM176B,FTH1,APOE,HTATIP2,RAB4A,LAPTM5,MSR1,ARL4C,EEF1B2,ADAP2,CD83,COL6A1,UST,THBS1,TGFB2,SNX10,LOC102724428/SIK1,DAB2,SEMA3B,CD53,UCP2,FCGR2A,HSPH1,VSIG4,PLXND1,LPAR1,TPP1,P2RY12,MAP4K4	59	
Molecular Transport	transport	transport of molecule	1.12E-12	Increased	3.860	bias	-0.505	NPM1,CTSG,PANX1,SLC9A1,PTPRC,LTF,CSE1L,GNA13,SLC2A5,CNR1,ANXA2,NPY5R,RPH3A,SLC38A3,HSPA8,MICU1,CTSA,CD300C,PRKACA,TFRC,ATOX1,SQSTM1,PLTP,SLC35B4,ADCYAP1,ESR2,SCN11A,STEAP3,FTH1,EPHX1,APOE,FHL1,SLC4A2,SLC1A5,CUBN,SEC23B,GDF15,DNAJA4,ADIPOQ,PPIA,CRAT,G6PC3,ARF6,SORBS1,PEX10,ARFGAP1,PLIN2,LY6E,BCAP31,NFE2L2,FCGR2A,SLC6A6,SLC39A6,SLC25A1,IPO7,TRIB3,SNCG,MYO5A,PPT1,DOPEY2,NR4A1,PSAP,BMPER,TTYH3,ABCC3,BMP6,NUTF2,SOCS3,TRAF3,AKR1C3,SESN2,ARL6IP5,SCAMP2,MBP,RABEP1,SCN7A,MCUR1,NME2,AP1B1,HSPA5,NPC1L1,GPC3,CD28,AK1,ABCB11,CHMP1A,STXBP1,STK39,YWHAB,PEX7,TNPO1,GM2A,KCNK2,ASNA1,CNP,SLC12A7,RAPGEF3,THRA,CITED1,SLC3A2,FOSB,BCL2L1,KCNG1,ADRA2A,SLC7A2,SIRPA,UBE2I,ATP6V0C,SCD,RAB4A,SLC1A4,MSR1,SCARA5,PYCARD,SLC38A1,VPS4A,IRAK1,SLC19A3,FYTTD1,SAA1,CRYM,LASP1,SLC20A1,AGFG1,AKR1C1/AKR1C2,NPY1R,DVL1,SNTB1,SYT11,TRPA1,DNAJC1,SOD1,ZPR1,FGF1,ATP6V1E1,CISD1,CIDEA,APLP2,SLC33A1,KIF5B,SLC36A1,FECH,SLC25A5,MAP4K4,SLC29A4,APOB,AHCYL1,RAN,HRAS,KPNA1,EXPH5,SNX12,ABCC6,CTSS,ABCC1,PXK,PNKD,CALCRL,CFL1,SLC24A3,NR1H3,STOML2,HMGA1,SERINC2,SLC25A22,BSG,FNDC1,RTN4,GLUL,MAP2K3,FH,C3AR1,SLC4A4,SORL1,SLC24A2,ATP6V0B,HLA-A,PPP1R3C,CDK16,XPOT,FOLR2,ATP6AP1,SLC52A2,C1QTNF3,CES1,PHB,MT-CYB,PRKCE,STIM1,SLC30A1,SMPD3,GJB2,SLC25A13,LETM1,EGR1,CASK,STXBP6,APP,FTL,SLC48A1,SLC25A11,SREBF1,FCER1G,PEA15,FKBP4,TSPO,NR5A2,P2RY12,GABARAP,ACTR1A,PLCB2,SLC31A1,SLC7A11,ATP5D,KCND3,ARF1,CD4,MAP1B,CXCL12,XPO5,ATP5L,DYNLT1,SLC27A4,CHTOP,VDAC2,SLC29A3,CAMK2D,PTGES2,ITGAV,NEO1,SLC7A5,GSK3B,RET,CLCN3,VPS11,HK1,SLC4A5,EIF2AK1,SLC6A8,ACSL3,FST,HSPA9,PHB2,RAB10,SLC39A3,ATP6V1A,PKN1,SEL1L,CD3G,ERP29,CDC42,IL1RN,MAPT,CD14,CLCN7,UHMK1,EIF5A,VDAC1,XPO6,ARL2,SPIRE1,CREBL2,LEP,RAB1A,VAPA,PKM,SLC7A1,CFTR,STXBP4,HIF1A,FAS,CLCN4,TACR1,HMOX1,SLC39A1,THBS1,KCNMA1,ANXA1,ERBB4,TGFB2,PRNP,CALR,CYP27A1,AP3D1,RAB7A,CLEC9A,GABBR1,SLC5A3,ANO2,SLC16A1,APOC1,NUCB2,CLDN2,CPEB1,ADAM9,SLC47A1,ATP6V1B2	297	
Infectious Diseases	infection	Viral Infection	1.28E-12	Increased	9.252	bias	3.289	NPM1,TWF1,PANX1,MNAT1,POR,PTPRC,GATAD2A,LTF,CSE1L,ETF1,ATF4,LSM3,MGAT1,EIF1AY,FGFR2,ANXA2,NRBP1,TMEM127,FSCN1,BTG2,NDUFB7,PSMA5,PRKACA,ATMIN,CTSB,GAPDH,TFRC,ATOX1,ADCYAP1,APOE,DDIT3,GBP1,ARPC1B,DAPK2,PRDX1,ARL4C,BAG6,ADIPOQ,LGALS9,PPIA,ATRAID,TECR,OGT,ARF6,ACTR3,HSP90AB1,FBXW11,LY6E,SERPINA1,CSNK2B,SNRPD3,S100A1,PLOD2,SIGMAR1,OAS1,MECOM,MED20,TNFRSF1A,FCGR2A,TUBB4B,RPS10,DGAT2,THAP11,SPATS2L,PVR,PSMB6,RPS16,CSF1,GCSH,ADRA1A,SDF4,EEF1A1,SOCS3,TRAF3,PCDH18,DPM1,RABEP1,RACK1,AP1B1,HSPA5,NPC1L1,CD28,HSPA4,TMEM132C,SAE1,RPS13,CHMP2A,NDUFS6,HOXA7,STAB1,UQCRFS1,TUBA1C,CHMP1A,ADAMTS5,STXBP1,HDAC2,STK39,GM2A,LAMA2,MAPK8IP2,CNP,POLR2K,ARRDC2,AES,BCL2L1,SDCBP,ADRA2A,DUSP1,EDEM1,NDUFA6,LSM1,IRF8,RPSA,ATP6V0C,ZC3H7B,ALG14,MSR1,PPIB,PYCARD,EIF2S1,HNRNPK,VPS4A,MLH1,C20orf24,F8,MED15,MCAM,LOC102724428/SIK1,RNH1,LONP1,SEC61G,AGFG1,TRIM55,TUBG1,DVL1,HSPD1,UTY,KDM5D,PSMD2,MAP4K4,SPCS1,RAB5C,APOB,AHCYL1,TXNL4A,RAN,HRAS,RAD23A,SGPL1,DUSP3,PRG4,CTSS,GAA,MED16,CHCHD2,TXN,CAPN6,TKT,TUBB2A,AASS,PCK1,HMGA1,COPB1,BSG,MS4A4A,STIP1,IL10RA,GLUL,MAP2K3,C3AR1,RAB32,LAPTM5,ATP6V0B,HLA-A,FKBP1A,PFKL,DCLK1,ATP6AP1,DCLK2,RPL35,MT-CYB,ANXA5,TOP2A,SNX10,PSMD14,RPS5,RPL18,PLOD3,PLAT,CD209,ANKRD9,DTX4,TYROBP,IMPDH2,ACTB,FGD6,EGR1,LRRC8D,STX10,COPG1,APP,EIF3G,ITGB2,FTL,LAMP2,PDIA6,SREBF2,BRINP2,C6orf48,CYCS,GABARAP,PLAU,CLUH,GAB2,PLCB2,SLC31A1,VPS28,ARF1,PRMT3,CD4,CXCL12,TUBB,CD63,NR2F1,CTBP1,ITGAV,CYBB,MID1IP1,GSK3B,SNU13,KLF2,FERMT3,PTX3,SPP1,CYB5B,SNRPF,TALDO1,HSPA9,CLTC,PSMC4,SLC4A7,HIST1H2BK,RPL12,CYSTM1,ATP6V1A,TPSAB1/TPSB2,CDC42,IL1RN,SH2B3,ATP6V0D1,RARRES3,CD14,UBE2E1,RPL13A,UTP11,LEP,ATF5,CFTR,NAA10,GANAB,RRAGD,FAS,SSU72,HMOX1,FLNA,ANXA1,F5,TGFB2,MICALL1,PSMA3,HMGCS1,ACTN1,PRNP,NDUFAF3,DLGAP4,AP3D1,R3HDM1,EXOSC5,RAB7A,GABBR1,F13A1,NFKBIZ,PLXND1,FAU,STT3A,RPS4Y1,APOC1,PANK3,MAT2A,UQCRC1,RTN3,MMP9,ATP6V1B2,RPL38	294	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of lipid	1.35E-12	Increased	4.742	bias	1.118	PLIN1,APOB,PMVK,VAC14,SH3GLB1,ODC1,POR,SGPL1,LTF,ABCC1,PLIN5,TXN,YWHAG,CNR1,NR1H3,ELOVL1,PLAA,HSPA8,SERINC2,NR1D1,DHRS9,ME2,B3GNT5,PLTP,ADCYAP1,HACD3,ESR2,APOE,RALA,DPM2,GDF15,ADIPOQ,PROX1,TECR,C1QTNF3,ARF6,CES1,GBA,PHB,SORBS1,MT-CYB,PLIN2,DAB2,SERPINA1,HPGDS,SMPD3,CD209,TNFRSF1A,FCGR2A,EGR1,SLC6A6,DGAT2,ALOX5AP,AGPAT1,TRIB3,SPTLC3,CYP1B1,STS,APP,MYO5A,FOS,ITGB2,SREBF2,CSF1,SREBF1,FCER1G,NR4A1,TSPO,NR5A2,PLAU,BMP6,NCAM1,MVD,EEF1A1,SOCS3,PLP1,PIGU,PRPF19,AKR1C3,ARF1,CD4,DPM1,CXCL12,NPC1L1,SLC27A4,CERS2,NR2F1,PGD,PTGES2,PLCE1,PCYT2,HOXA10,FAR2,MID1IP1,MTMR2,GPC1,DPM3,NSMAF,PTX3,ACSL3,PEX7,DGKE,ARSA,SMPD2,GPAA1,BCL2L1,CDC42,IL1RN,ALDH1A2,MPDU1,MAPK10,CD14,AKR1B1,CYP4A11,CNBP,PPAT,CREBL2,SCD,IGFBP4,LEP,PDGFA,PKM,UGCG,CFTR,CD83,ME1,FAS,TNFRSF12A,TACR1,HMOX1,PARK7,DKK3,ANXA1,ERBB4,KIT,CTDNEP1,PI4KB,PRNP,AKR1C1/AKR1C2,CYP27A1,EDNRB,MAP3K1,SOD1,CEBPB,THRSP,DEGS1,FGF1,SERPINE2,APOC1,MMP9	150	
Cancer, Organismal Injury and Abnormalities	advanced malignant tumor	advanced malignant tumor	1.76E-12	Increased	3.168	 	1.964	NPM1,CTGF,RRM2B,HRAS,GYG2,RPS11,PTPRC,POR,DGCR6L,LTF,CSE1L,TMSB10/TMSB4X,KLF8,MFAP5,PTP4A3,GSTM3,TUBB2A,FGFR2,HMGA1,ROR1,CD52,HAX1,ISLR,CCND2,FSCN1,CTSB,ALCAM,GLUL,MAP2K3,LRP8,DUSP4,SFRP1,SQSTM1,CYR61,SETBP1,PDCD5,ESR2,STEAP3,GSTP1,ALK,S100A11,APOE,NME1,MSC,ADAM17,HTATIP2,GSTM5,TCEA1,NID2,ARL4C,DUSP6,HMGN1,GDF15,HYOU1,LGALS9,PPIA,FKBP1A,PROX1,COL15A1,ENAH,ARF6,HSP90AB1,PHB,ANXA5,TOP2A,PRKCE,DAB2,SERPINA1,STIM1,SMPD3,MYL12A,PLAT,PLOD2,MECOM,IMPDH2,FCGR2A,TUBB4B,ACTB,GNA12,SNCG,CYP1B1,FOS,FTL,CSF1,USP22,EIF4A1,P2RY12,PSAP,PLAU,ABCC3,NCAM1,EEF1A1,SOCS3,SLC7A11,AKR1C3,RACK1,CXCL12,RNASE1,TUBB,NR2F1,CD28,HOXA10,CYBB,ITGAV,IFI30,STAB1,ANXA7,TUBA1C,C1QBP,RET,CLCN3,PTX3,TBC1D2B,SPP1,FST,FSTL3,HDAC2,KCNK2,CDK6,HNRNPAB,SLC12A7,CAPG,KLF4,LMCD1,EFS,BCL2L1,CD3G,PPP2R1A,SDCBP,ADAM12,IL1RN,ALDH1A2,NUAK1,CAPN2,TFPI,TMEM176B,POLE3,CD151,SCD,IGFBP4,ERAP2,SRPX,EPB41L3,PDGFA,MMP14,HIF1A,FAS,TNFRSF12A,HMOX1,PSMD10,CCDC88A,THBS1,FLNA,KCNMA1,ANXA1,MCAM,ERBB4,TGFB2,LOC102724428/SIK1,KIT,RNH1,HCST,ALPL,PRNP,SEC61G,VCAM1,NDUFB4,AKR1C1/AKR1C2,TP63,EDNRB,BHLHE41,TUBG1,CSF1R,SLC5A3,NDUFA13,ATIC,FGF1,EMP1,C2orf88,CLGN,TNFAIP8L2,CLDN2,ADAM9,MMP9	184	
Cellular Assembly and Organization	development	development of cytoplasm	1.99E-12	Increased	3.700	bias	1.051	NPM1,CTGF,TWF1,HRAS,SLC9A1,CLIP1,GNB1,DYNLL1,ATG9A,GLB1,CHCHD2,AIF1,GNA13,TESK1,GNG12,CFL1,TPM3,STOML2,MALSU1,JUNB,HAX1,MRPL14,MYL9,HSPA8,NR1D1,GPR65,C3AR1,APOE,SLC4A2,CDH11,SMARCA4,ARF6,ACTR3,RHOD,PEX10,SORBS1,DAB2,PRKCE,TUB,GNG5,AMOT,PLAT,LETM1,FCGR2A,GNA12,ACTB,POLDIP2,APP,FIS1,SUPV3L1,COL5A3,LAMP2,MYOC,FKBP4,ARAP1,PLAU,PFN1,ARF1,MAP1B,CXCL12,SDC4,TUBB,CTSD,PACS2,NDUFS6,GSK3B,KLF2,HDAC2,CNP,GNG2,CDK6,RAPGEF3,MLST8,UBXN11,LMCD1,BCL2L1,ERP29,CDC42,MAPT,SIRPA,ARL2,TFEB,RAB1A,LEP,PYCARD,PHLDB2,VPS4A,TACR1,TWF2,PARK7,FLNA,THBS1,ANXA1,ARHGEF2,ASAP3,RPS3,VCAM1,CAPZB,TP63,IPO4,MAP3K1,MGAT5,SYNPO2,FGF1,KCTD13,LPAR1,NCKAP1L	107	
Cellular Movement	cell movement	cell movement of blood cells	2.04E-12	Increased	3.064	bias	-0.508	NPM1,CTGF,APOB,CTSG,HRAS,CHST2,PTPRC,SGPL1,LTF,CTSS,ABCC1,TXN,GNA13,AIF1,TMSB10/TMSB4X,ZBTB16,LCP1,CNR1,FLOT1,ANXA2,NINJ1,YARS,MS4A4A,CTSB,IL10RA,RTN4,ALCAM,MAP2K3,SFRP1,PLTP,CYR61,ADCYAP1,C3AR1,ESR2,APOE,ADAM17,DAPK2,PRDX1,HLA-A,NQO2,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,PROX1,G6PC3,LIPA,LYZ,CES1,GBA,RHOD,ANXA5,SERPINA1,STIM1,NFE2L2,GJB2,PLAT,IL11RA,RPS19,CD209,UCP2,TYROBP,TNFRSF1A,FCGR2A,ACTB,EGR1,GNA12,ALOX5AP,PVR,CYP1B1,APP,GRN,FOS,ITGB2,MT-ND1,EDIL3,GLIS2,CSF1,DOCK8,SREBF1,TREM2,FCER1G,NR4A1,PLAU,NAB2,SOCS3,GAB2,PLCB2,PFN1,PLP1,CMA1,CD4,UNC5B,RACK1,CXCL12,GPC3,CD63,CD28,NARS,CXCL14,CYBB,ITGAV,HOXA7,NEO1,STAB1,C1QBP,KLF2,FERMT3,PTX3,SPP1,KCNK2,CNP,CAPG,FYB,SMPD2,TPSAB1/TPSB2,EFS,CDC42,IL1RN,DUSP1,SH2B3,IGFBP3,MAPK10,CD14,TFPI,AKR1B1,SIRPA,RPL13A,CD151,LITAF,LEP,MSR1,PPIB,PLGRKT,PYCARD,MMP14,CFTR,HIF1A,FAS,TACR1,HLA-G,HMOX1,SHC1,CCDC88A,THBS1,FLNA,ANXA1,MCAM,EFNB1,DUSP10,SAA1,TGFB2,KIT,EGLN3,MAPKAPK2,PRNP,SEMA3E,CALR,VCAM1,EDNRB,NQO1,MGAT5,HYAL1,ST3GAL6,TRPA1,F13A1,SOD1,HSPD1,NFKBIZ,CSF1R,PLXND1,FGF1,CXCL16,TNFAIP8L2,C6,CHI3L1,NCKAP1L,MMP9	179	
Cellular Movement, Immune Cell Trafficking	migration	leukocyte migration	2.69E-12	Increased	3.040	bias	-0.506	NPM1,CTGF,APOB,CTSG,HRAS,CHST2,PTPRC,SGPL1,LTF,CTSS,ABCC1,TXN,GNA13,AIF1,TMSB10/TMSB4X,ZBTB16,LCP1,CNR1,FLOT1,ANXA2,NINJ1,YARS,MS4A4A,CTSB,IL10RA,RTN4,ALCAM,MAP2K3,SFRP1,PLTP,CYR61,ADCYAP1,C3AR1,ESR2,APOE,ADAM17,DAPK2,PRDX1,HLA-A,NQO2,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,PROX1,G6PC3,LIPA,LYZ,CES1,GBA,RHOD,ANXA5,SERPINA1,STIM1,NFE2L2,GJB2,PLAT,IL11RA,RPS19,CD209,UCP2,TYROBP,TNFRSF1A,FCGR2A,ACTB,EGR1,GNA12,ALOX5AP,PVR,CYP1B1,APP,GRN,FOS,ITGB2,MT-ND1,EDIL3,GLIS2,CSF1,DOCK8,SREBF1,TREM2,FCER1G,NR4A1,PLAU,NAB2,SOCS3,GAB2,PLCB2,PLP1,PFN1,CMA1,CD4,UNC5B,RACK1,CXCL12,GPC3,CD63,CD28,NARS,CXCL14,CYBB,ITGAV,HOXA7,NEO1,STAB1,C1QBP,KLF2,FERMT3,PTX3,SPP1,KCNK2,CNP,CAPG,FYB,SMPD2,TPSAB1/TPSB2,EFS,CDC42,IL1RN,DUSP1,SH2B3,IGFBP3,MAPK10,CD14,TFPI,SIRPA,RPL13A,CD151,LITAF,LEP,MSR1,PPIB,PLGRKT,PYCARD,MMP14,CFTR,HIF1A,FAS,TACR1,HLA-G,HMOX1,SHC1,CCDC88A,THBS1,FLNA,ANXA1,MCAM,EFNB1,DUSP10,SAA1,TGFB2,KIT,EGLN3,MAPKAPK2,PRNP,SEMA3E,CALR,VCAM1,EDNRB,NQO1,MGAT5,HYAL1,ST3GAL6,TRPA1,F13A1,SOD1,HSPD1,NFKBIZ,CSF1R,PLXND1,FGF1,CXCL16,TNFAIP8L2,C6,CHI3L1,NCKAP1L,MMP9	178	
Carbohydrate Metabolism	metabolism	metabolism of carbohydrate	2.81E-12	Increased	3.455	bias	0.330	GFPT1,PLIN1,CTGF,RPE,SGSH,VAC14,HRAS,SH3GLB1,CHST2,PTPRC,GNB1,FUOM,IP6K3,GYS1,CCND3,LTF,GLB1,GAA,ATF4,MGAT1,CLN6,ALDOC,TKT,PCK1,SERINC2,NR1D1,BSG,CTSB,GAPDH,ALDOA,SFRP1,B3GAT3,ADCYAP1,EPHX1,APOE,RALA,HLA-A,PPP1R3C,DUSP6,DPM2,HS2ST1,LRP6,ADIPOQ,HEXA,PFKL,G6PC3,ARF6,SORBS1,DCXR,PLAT,OAS1,TNFRSF1A,FCGR2A,FUCA2,DGAT2,AGPAT1,APP,ITGB2,NTRK3,CSF1,SREBF1,NR4A1,PLAU,ADRA1A,EEF1A1,SOCS3,PLCB2,GNPDA1,PIGU,PFKFB1,ARF1,DPM1,CD28,HS6ST1,PGD,PCYT2,ITGAV,CHST11,PGP,GOT1,MTMR2,GSK3B,GPC1,DPM3,HK1,PFKFB3,NAGA,SPP1,XYLT1,GM2A,GNG2,GCNT2,TALDO1,CLTC,RAB10,FIG4,GPAA1,ADCYAP1R1,CDC42,IL1RN,MPDU1,IGFBP3,NAGLU,PLEK,AKR1B1,AKR7A2,SULF1,PTGFR,ANGPTL8,SCD,B3GALT6,TFEB,LEP,PDGFA,PKM,HIF1A,FAS,TACR1,ANXA1,TGFB2,KIT,STK40,PI4KB,ADCY2,NPY1R,NQO1,ST3GAL6,HYAL1,PYGB,GUK1,CEBPB,SLC5A3,CSF1R,GBE1	134	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoplasm	3.62E-12	Increased	3.396	bias	-0.605	ADAMTS8,REM1,PCLO,C1QA,PLEKHM2,SLC9A1,CLIP1,LTF,GLB1,GORASP2,DGKG,PRKY,GNA13,KNSTRN,TMSB10/TMSB4X,CLN6,LCP1,CNR1,TPM3,FLOT1,FGFR2,DES,NDN,TMEM127,FSCN1,BTG2,GPR65,PRKACA,ATMIN,GAPDH,ADCYAP1,ACTG1,APOE,NME1,PLXNA3,CHCHD10,GDF15,ADIPOQ,HEXA,SDK1,SYNM,CETN2,ARF6,ACTR3,SORBS1,PEX10,AMOT,S100A1,TNFRSF1A,FCGR2A,GNA12,PVR,RNF6,CPEB4,GRN,MYO5A,FOS,MYOC,NTRK3,CSF1,FLNC,PPT1,DOPEY2,TPP1,ARHGDIA,SOX9,BMP6,EEF1A1,NCDN,SEPT9,SESN2,EML4,MBP,NTMT1,BAG3,NNMT,RHOG,HOXA7,CDC42EP1,HDAC2,PTPRQ,PEX7,LAMA2,MAPK8IP2,CNP,RAPGEF3,CAPG,ARSA,SMPD2,MLST8,TXNRD1,SLC3A2,ADRA2A,ADAM12,MATN2,NAGLU,CAPN2,SIRPA,UBE2I,SULF1,TFEB,FLRT1,HNRNPK,PHLDB2,SHC1,TWF2,LOC102724428/SIK1,KLHL42,DNAAF1,RPS3,LONP1,LASP1,WDR1,AGFG1,CAPZB,TUBG1,DVL1,NQO1,HPS1,MGAT5,EMD,SOD1,KIF3B,ZPR1,FGF1,KCTD13,KIFC3,CAPNS1,KIF5B,TTL,TBC1D7,RAB5C,CTGF,ITGA8,SH3BGRL3,ARPC5,RAN,MARK1,HRAS,SH3GLB1,KPNA1,BBS1,DYNLL1,ABR,CTSS,GAA,ABCC1,KIF21A,AFAP1,TESK1,RIMS3,CAPN6,CFL1,STOML2,ROR1,CLN5,NINJ1,BSG,STIP1,RTN4,ALDOA,LRP8,CDK2AP2,SFRP1,CYR61,RALA,BTG3,CDK16,TMEM11,SDC3,DCLK1,ENAH,UCHL1,DCLK2,SEC61A1,PHB,UST,RHOD,SRGAP1,SNX10,ACAP2,TUB,PRKCE,NPTXR,PLAT,IL11RA,PTPRK,ACTB,EGR1,ARL3,APP,FIS1,TENM4,SREBF1,TREM2,ADCY1,ARAP1,FKBP4,ATXN10,P2RY12,GABARAP,PLAU,RUFY3,MAPRE3,NCAM1,CLUH,PFN1,PTPN23,ARF1,MAP1B,UNC5B,CXCL12,SDC4,DYNLT1,TUBB,NR2F1,COMT,ITGAV,NEO1,MID1IP1,GSK3B,C1QBP,RET,KLF2,DSP,FERMT3,PTX3,SPP1,ACP2,CLTC,PHB2,RAB10,LMCD1,CDC42,MAPT,MAPK10,RARRES3,NUAK1,UHMK1,PLEK,STXBP5,ARL2,SPIRE1,GEM,RNF165,LEP,RAB1A,EPB41L3,PDGFA,VAPA,PKM,UGCG,FAS,TNFRSF12A,CCDC88A,PARK7,THBS1,FLNA,DKK3,ANXA1,ERBB4,EFNB1,TGFB2,KIT,MICALL1,ARHGEF2,NSMF,SHANK2,MAPKAPK2,PI4KB,ACTN1,PRNP,SEMA3E,CALR,MAP3K1,F13A1,PLXND1,CSF1R,LPAR1,SLC16A1,EPHB3,NCKAP1L,RTN3	283	
Cancer, Organismal Injury and Abnormalities	cancer	cancer	3.75E-12	 	-0.655	 	-0.592	PCLO,VAC14,GARS,LRRN4CL,GNB1,GLB1,GNA13,RNPEPL1,SRPRA,MYL9,NDUFB7,PSMA4,ALCAM,TMEM43,ELMO2,KDM1B,DDIT3,SLC1A5,RABL6,ACSS3,LY6E,MTSS1L,RNF157,AFF3,KIF7,EDIL3,ATP6V1F,DERL1,WBP2,NR4A1,PIGU,AKR1C3,EML4,STRN4,STC2,ANKDD1A,SNRPD1,MTMR2,TUBA1C,NSMAF,WDR93,UBL4A,LSM1,NAGLU,POLD2,ZC3H7B,SCD,CARS,FLRT1,FAT3,C20orf24,COL6A1,IGSF8,LASP1,AKR1C1/AKR1C2,ANKRD20A5P,PYGB,CFAP97,UTY,TBL1Y,RAP2B,GFPT1,CTGF,ITGA8,CA12,SGPL1,ZBTB7B,C9orf91,SLC22A15,ZNF605,FAM124B,PNKD,KLF8,ZBTB16,PTP4A3,CNOT10,NINJ1,ACAD11,ISLR,SCRN1,SNRNP25,NCLN,RMND1,FKBP14,HLA-A,NQO2,LRP6,FKBP1A,CCAR2,RUVBL1,MRPL30,H2AFZ,ATP6AP1,TUB,TXNL1,FKBP5,ACVR1C,LIMCH1,GJB2,CD53,CD209,EGR1,ZFY,COPS3,CALM1 (includes others),C8orf33,NIPSNAP3A,AOX1,NCAM1,PNO1,PDZD11,ZBTB47,FAM127B,CHTOP,CNDP2,PTGES2,COMT,GOT1,POLR1A,PSMF1,CLTC,SLC4A7,MAGED2,ATP10A,RPL12,TPSAB1/TPSB2,CYP4A11,FPR3,GEM,FLYWCH2,NELFE,HINT1,DUSP10,CYGB,TMEM104,EMP1,PLCB4,PAG1,HLTF,IGSF6,RRM2B,PCDHAC1,CLSTN2,SLC35C1,RAB38,CLN6,MRPL24,ICT1,CD52,HAX1,NRBP1,SCUBE1,MRNIP,AARS,TRAPPC5,MRPL37,FKBP2,APOE,NME1,SFXN4,CDH18,C9orf24,ARL4C,SEC23B,ZDHHC11B,PROX1,ATRAID,SDK1,OGT,HSP90AB1,ARFGAP1,PLIN2,FBXW11,ALG8,RPN1,S100A1,SIGMAR1,RPL4,MLF2,SLC39A6,DGAT2,YPEL1,SNCG,CPEB4,NTRK3,SERPINH1,EIF4A1,ARHGDIA,BTF3L4,C6orf62,PPIL1,ID4,BZW2,MEGF9,USP5,TMEM8A,SLC41A3,PPFIBP2,MRPL47,NME2,RNASE1,SLC35F6,MRM2,C3orf17,CEBPG,CD28,TMEM132C,MOCOS,HOXA10,PACS2,HOXA7,DPM3,GULP1,PFKFB3,FSTL3,RERG,CMSS1,SDHC,ARSA,DNAJC5,XRCC6,TXN2,ALDH1A2,UHRF1BP1L,CALHM2,RAB4A,AUP1,ME1,FYTTD1,DNAJC4,ZNF483,ACAD8,RHOBTB2,RPS3,IARS,FAM171B,AGFG1,DCTN3,MGAT5,PSME3,FAM49A,DEGS1,NFE2L1,KDM5D,TBC1D7,CHI3L1,SPCS1,PMVK,MAF,SH3GLB1,PCDH7,C1QB,KPNA1,ADGRL1,DYNLL1,ABR,ABCC1,GSTM3,PDRG1,NR1H3,STOML2,TSPAN33,ZNF414,CLN5,SERINC2,NUGGC,MS4A4A,MS4A7,PSMB10,CDK16,CTNNA1,KAZN,DCLK2,IFRD2,SRGAP1,TBC1D12,PRKCE,NACC1,YIPF2,PLOD3,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,MRPL51,CLDN5,DOCK8,ADCK2,PRMT5,P2RY12,GAB2,PLP1,CYBB,ADPRHL2,KLHL11,LMO4,SGCG,PSMC4,PLEKHH2,IL1RN,STXBP5,PHF1,PRDX5,EPSTI1,FAM47E,GANAB,FLNA,GSTM4,BHMT2,SEMA3E,DLGAP4,CENPV,C10orf71,AP3D1,F13A1,CCDC58,AHCYL2,MKNK2,CSF1R,ARHGEF10L,TNFAIP8L2,ITPA,PANK3,CLDN2,ATP6V1B2,CARM1,REM1,TMEM184B,NPAS2,GPR55,SPRY4,CCND3,CSE1L,DGKG,KNSTRN,AHCY,YWHAG,HCFC1R1,LAIR1,SURF1,MSMO1,PRKACA,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,FTH1,EVA1B,HTATIP2,PSMD7,DAPK2,BAG6,DPM2,SMARCA4,COL15A1,FKBP3,PLOD2,OAS1,UCP2,MECOM,PTRH1,SLC25A1,RNF6,CSTB,MYO5A,RPS16,CSF1,SEPHS1,SOX9,SLC9A9,GPC3,CTSD,TSEN15,CHMP2A,ERAL1,ADAMTS5,NAGA,STXBP1,SESN3,STK39,UROS,MAPK8IP2,ASNA1,FIG4,CREG1,RPL37A,SMPD2,ADRA2A,TFPI,UBE2I,DDX21,ALG14,SULF1,LITAF,F2RL3,HABP4,PCDHGB4,ZNF219,ALAS1,FILIP1,FARSB,PSMD10,RPL18A,CRYM,PATL1,PREB,TRIM55,CSRNP1,TSN,APLP2,C7orf43,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,MKI67,EIF6,GSS,RPS11,RAD23A,BBS1,AHSA1,LGMN,DUSP3,MPV17L2,PLCXD1,POU6F2,MGAT4B,MED16,SYT2,TESK1,CAPN6,DPY19L1,DKC1,JUNB,COPB1,ROR1,BCAP29,TSR3,FARSA,INPP4B,C19orf53,FNDC1,RTN4,CCT3,EBNA1BP2,SETBP1,PDCD5,KLHL18,GSTM5,BTG3,PPP1R3C,TTLL4,HYOU1,GPC4,ASNS,EAF1,CDH11,SDCCAG3,NDUFB9,CES1,PHB,DCXR,PGAM1,MYO1D,NPTXR,MYL12A,PLXNA1,PTPRK,NOL6,DDX3Y,PAICS,TIAL1,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,CCDC85B,SLC48A1,SLC25A11,RHBDD2,SREBF1,BMF,USP22,TREM2,APOL4,NAB2,KCND3,UBE2A,HIST1H2BC,ARF1,PRMT3,CD4,MAP1B,UNC5B,MYH15,CD63,SLC25A6,CAMK2D,PABPC4,CDON,PCYT2,ANXA7,C1QBP,GPC1,GSK3B,RET,MRPS15,DSP,MFSD3,HK1,TRIOBP,GSDMB,XYLT1,TALDO1,GNG2,DGKE,HIST1H2BK,GPAA1,UBXN11,NUAK1,CD14,EIF5A,CLCN7,PLEK,DNPEP,SPIRE1,CREBL2,ARL2,SRM,TOLLIP,RAB1A,SFRP2,KIAA1191,ATF5,ILF2,CD83,RRAGD,HSPE1,OAZ1,EGLN3,WSB2,OGDH,ATP5I,ADAMTS15,BHLHE41,HSPH1,R3HDM1,OAF,GUK1,IL20RB,PLXND1,P4HA1,CYC1,APOC1,NUCB2,EPHB3,UQCRC1,GRPEL1,ADAM9,KLHDC8B,LRRC59,CTSG,TIGIT,COL8A1,NEXN,PLEKHM2,CLIP1,FADS3,IP6K3,MCOLN3,LSM3,TMSB10/TMSB4X,TPM3,NPY5R,RASL12,TMEM127,HSPA8,GPR65,BTG2,ATMIN,TMEM33,SCN11A,RPL41,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,COL16A1,SORBS1,TTC23,STT3B,TMC2,TNFRSF1A,SPTLC3,GRN,FOS,DOPEY2,TTYH3,TSC22D2,C11orf68,ABCC3,SIGLEC6,SGCD,PPIP5K2,PTER,NUTF2,ICMT,OGFOD1,STARD7,NPC1L1,HSPA5,FAM117B,ENTPD5,FAR2,CDC42EP1,LACTB,YWHAB,KCNK2,LAMA2,HNRNPAB,PGAP3,CAPG,KCTD15,DMXL2,KCNG1,CDH20,MRPS2,IRF8,RPSA,DOK5,UBXN1,ATP6V0C,MSR1,SF3B5,COPE,TMEM60,LEO1,REXO2,HNRNPK,SLC19A3,SHC1,PREPL,KIAA0232,SAA1,PPP1R2,TRABD2A,RNH1,LIAS,RAD23B,CAPZB,NPY1R,NDUFV3,PWWP2B,NQO1,TRPA1,LARP6,NRBF2,FGF1,PDAP1,SHB,CISD1,CXCL16,CIDEA,SCARA3,KIF5B,SLC36A1,NOP16,COX5A,EMC3,GXYLT2,SLC29A4,KCNK15,CADM3,APOB,PLIN1,C9orf72,MMEL1,SH3BGRL3,TXNL4A,LDB3,MARK1,HRAS,CECR1,PEG10,ANAPC11,CALCRL,CFL1,SLC24A3,THSD4,TKT,FAM126B,TUBB2A,AASS,CTPS1,CD68,CNTNAP4,MBD4,MAP2K3,SFRP1,TCF7,C3AR1,MYEOV,S100A11,RAB32,LAPTM5,ZNF330,RPS3A,NID2,HMGN1,ADAP2,XPOT,DCLK1,RNF24,UCHL1,FANCE,C1QTNF3,RPL35,ACSM5,SLC2A6,SAMD1,SNX10,TPO,NDUFS4,ADRM1,DTX4,TYROBP,FGD6,ACTB,WDR12,CYP1B1,AREL1,COPG1,EIF3G,PDIA6,PPP1R16B,ADCY1,FCER1G,ARAP1,NR5A2,CBX4,DVL3,ATP5D,UTP4,TUBB,VDAC2,RAB11FIP2,NR2F1,EIF5,PUSL1,SLC7A5,NEO1,IGFBP6,C6orf132,SNRPF,GCNT2,PKN1,TIE1,EPRS,SEL1L,PPP2R1A,ADCYAP1R1,GNL3,VDAC1,TMOD1,RPL13A,CEACAM21,VAPA,RBBP8,SLC7A1,UGCG,STXBP4,HIF1A,NAA10,SOX17,HMOX1,CCDC88A,NLK,CSPG4,ANXA1,F5,SELENOH,ARHGEF2,SEMA3B,HMGCS1,STK40,CTDNEP1,ALPL,PI4KB,PRNP,TAF6,CYP27A1,COPS7A,NXPH4,GABBR1,ZBTB7C,NDUFA13,WARS,SLC27A3,RTN3,TIMM13,ASS1,EEF1G,POR,GORASP2,DEFB132,VIT,DCAF12,SYT17,ANXA2,RPH3A,PLAG1,RCC2,CD300C,RCN3,ACTG1,FHL1,GBP1,ADIPOQ,MFSD5,PPIA,SYNM,ALPK2,AMOT,IPO7,PSMB6,MARCKSL1,MTHFD1L,GCSH,BTBD2,RPL37,EEF1A1,DIRAS1,DNAJC15,CBX5,LHFPL2,HS6ST1,ABCB11,ARRDC2,GUF1,BCL2L1,RPL8,RBX1,TMX2,CBX3,ETV5,SUMO3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,F8,GID4,C16orf59,DNAAF1,NDUFB4,SEC61G,SNTB1,SOD1,SAA2,RPS29,VAT1,RPS15,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,TUBA1B,FAM19A5,ABCC6,LRFN5,PRG4,PXK,GPR26,BIRC7,SV2B,CENPB,KAZALD1,HMGA1,MALSU1,SH3GL1,ARHGAP35,SORL1,ST6GALNAC4,SDC3,RNF185,MAFG,CADM2,UST,MYO5C,MT-CYB,SCN3A,DIP2B,HPGDS,RPS5,SMPD3,RPL31,RPS24,CCDC68,NAP1L4,RRP1B,SLC25A13,ANKRD9,SYNGR2,TRIM28,PSMD8,STS,ATXN10,CLUH,RGMA,SLC27A4,FAM173A,PLCXD3,PLCE1,DPP3,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,ANKMY2,IRX6,LAGE3,RPL29,FAM45A,GALNT13,SLC39A3,TARS,ATP6V1A,TMEM189,YIF1A,UTP11,AKR7A2,HIGD1A,PCDHAC2,PCDH19,CLCN4,MPEG1,SSU72,DKK3,THBS1,ASAP3,TPST2,SZRD1,RPS21,CEBPB,SYNPO2,THRSP,ANO2,RPS27L,NCKAP1L,PPP2R1B,SLC47A1,MPV17,SCFD2,CSTA,CA5B,KCMF1,PANX1,ODC1,NPL,GATAD2A,SRPX2,LTF,COMMD2,HIGD2A,PLEKHO2,SPTB,STAM,MGAT1,GNG12,ALDOC,ALDH1B1,PLD3,MFAP5,CNR1,RPAP3,SMOC2,DCTD,PXDC1,DES,SPATA20,PYGO2,AACS,CYP4B1,GCC1,TFRC,DUSP4,CHD1L,SQSTM1,ESR2,DEAF1,AASDHPPT,FBXO10,SLC4A2,PLXNA3,HN1,CUBN,HS2ST1,GDF15,WDR61,EEF1B2,CRAT,LGALS9,TECR,COPS8,CCT4,PEX10,TNXB,ATP5J2,DAB2,SERPINA1,SNRPD3,NFE2L2,P4HA2,MED20,FUCA2,GNA12,GLRX2,SLC6A6,STON1,LZTS2,THAP11,C1orf122,TBC1D13,MYOC,PSAP,TPP1,BMPER,SIM1,BMP6,ADRA1A,TRAF3,NCDN,TPPP3,ARL6IP5,ACO2,BAG3,TYMP,CES2,IMP4,MRVI1,BIN1,NNMT,SAE1,RPS13,GDE1,CXCL14,NUPR1,STAB1,PSMB5,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,TRIM35,PSMD3,FOSB,TLN2,SDCBP,ADAM12,MATN2,CCPG1,TMEM176B,POLE3,ERAP2,PTGFR,SLC1A4,SRPX,SCARA5,PYCARD,MECR,SLC38A1,LBHD1,VPS4A,RAP1GDS1,IRAK1,MED15,MCAM,LOC102724428/SIK1,ATP13A2,WDR1,SLC20A1,ECHDC2,VCAM1,EDNRB,ST3GAL6,HSPD1,ATIC,AIFM2,SERPINE2,ATP6V1E1,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,VWA5A,MUC7,CHST2,BCAT1,CTSS,HADHB,RPS2,RIMS3,TMEM9B,ARRDC4,ZNF592,PCK1,KIAA0100,MRPL14,DHRS9,YARS,IL10RA,ALDOA,LRP8,P2RY8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,FOLR2,ACSF2,PFKL,SP2,TAX1BP3,LIPA,MACC1,ANXA5,C11orf24,RPS12,SARS,IL11RA,PLAT,RPS19,C9orf142,URB1,FTL,UQCR10,PEA15,CYCS,RUFY3,MAPRE3,MVD,HOXB5,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,RPL13,ACOT1,IFI30,SIAH2,LPIN2,CLCN3,MRPL43,PTX3,TBC1D2B,SPP1,GPS2,ANLN,MACROD1,GLYAT,ERH,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,HSPA13,MAPK10,ACOT4,UHMK1,AKR1B1,RNPEP,SPX,B3GALT6,LEP,PDGFA,MMP14,SLFN5,PHYH,NLGN4Y,SENP3,MICALL1,HSD11B2,PSMA3,RBM18,UBA5,FRMD1,TMEM126B,ADCY2,RARS2,FAU,ENO1,SLC16A1,OLFML2B,TANGO2,MMP9,SHMT2,NPM1,ADAMTS8,RPE,PPP1R14B,ALPK3,ATG9A,SYPL1,AIF1,SLC2A5,FBXO8,CTSB,NHLH1,ARPC1B,PRDX1,AAK1,FCGR2A,TUBB4B,SPATS2L,PVR,C1orf123,SDF4,SLC25A43,SOCS3,PCDH18,SEPT9,ZNF79,DPM1,RABEP1,SCN7A,AP1B1,OSCP1,CCT5,FNDC4,UQCRFS1,C12orf49,C2orf83,HDAC2,CBX6,EIF4E2,FYB,MIIP,TXNRD1,OLA1,SLC7A2,TNS1,PPAT,IGFBP4,PLGRKT,PHLDB2,HLA-G,GTPBP2,KLHL42,HSPB6,MT-CO1,TP63,IPO4,TRIM2,KIF3B,WIPF3,POLR3B,HOXA6,GYG2,EXPH5,KIF21A,AFAP1,CPNE4,ELOVL1,NGRN,ME2,B3GNT5,GSTP1,TMEM11,ENAH,LYZ,TTC7B,TRIM16,SLC30A1,LAMB4,PPIF,LPCAT4,CSRNP2,WDR18,LRRC8D,PSME1,IMMT,BRINP2,PLCB2,GTF3C6,PFN1,C8orf82,TCEB2,METAP2,GSPT1,ALDH3A2,LYNX1,RPL19,POMP,PHPT1,BCKDK,MDH2,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,ACSL3,HSPA9,CD3G,MAPT,TMEM176A,SH2B3,RARRES3,LFNG,TBC1D16,CNRIP1,SH3RF3,MRPS30,SLC39A1,ERBB4,FMO1,SHANK2,KCTD1,CACNG8,MAPKAPK2,CALR,COL5A2,PHLDA3,RNF43,MAP3K1,CLEC9A,VSIG4,MRPS16,KIAA1683,PLBD2,TMEM2,RPS4Y1,C2orf88,ASAP2,GBE1,C6,SEMA4B,RPL38,PSG2,WHSC1,C1QC,MNAT1,SLC9A1,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,LMX1A,UNG,UXS1,LCP1,PPP1R1B,TMEM201,PPTC7,TIMM8B,FLOT1,FGFR2,COX7A1,NDN,CTSA,TOMM22,FBXW5,FSCN1,PRELP,PSMA5,GAPDH,SLC35B4,STEAP3,CHCHD10,PHLDA2,HSPB8,ARF6,ACTR3,FAM102A,OSBPL11,LURAP1L,CSNK2B,RPP25L,SRA1,ZNF362,ALOX5AP,TRIB3,XIST,HSPA2,GIN1,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,MBD3,CCT7,CSTF3,SESN2,MBP,RACK1,HSPA4,RHOG,MEGF6,GCLM,CHMP1A,BCAS2,C20orf27,GM2A,SRPRB,EIF2B3,RAPGEF3,CITED1,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,SLC25A39,NDUFA6,LIMA1,IGFBP3,PIK3AP1,CAPN2,MEGF8,SIRPA,CD151,MLH1,NDUFA2,RPL14,TWF2,FAM166A,UBIAD1,LONP1,PSAT1,ZNF358,HPS1,TUBG1,EMD,KIFC3,TTL,MUC17,IVD,FHL5,NR6A1,AHCYL1,SGSH,NCSTN,DGCR6L,GAA,TXN,WNT5B,NANOS1,CPA3,CCND2,BSG,NR1D1,LMOD2,STIP1,GLUL,ADM2,CYR61,ALK,ENOPH1,ADAM17,SLC24A2,MSC,TCEA1,UBQLN1,DUSP6,TTC1,SEC61A1,GBA,ACAP2,TOP2A,HLCS,PSMD14,STIM1,ZNF70,ADGRB2,COX4I1,AMFR,MYH1,DNAH12,LETM1,IMPDH2,APP,WARS2,B4GALT2,FIS1,SUPV3L1,SREBF2,GABARAP,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,SDC4,TAF10,MMRN1,MTCH2,CTBP1,SLC29A3,NARS,PGD,ITGAV,RAD51C,KLF2,EIF2AK1,DNASE2,RAB10,CDK6,ST6GALNAC3,LMCD1,EFS,ATP6V0D1,DNAJC18,JTB,RNF165,EPB41L3,KLRD1,PKM,CFTR,LDLRAD3,ERV3-1,FAS,TNFRSF12A,SEPHS2,TACR1,EVC,PCK2,NDUFC2,KCNMA1,EFNB1,TGFB2,TCP1,KIT,NR2F6,HCST,ACTN1,NDUFAF3,TRAF7,COX17,VANGL1,QSOX1,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,MAT2A,USP9Y,SCAND1	1582	
Neurological Disease	progressive motor neuropathy	progressive motor neuropathy	5.99E-12	 	1.063	 	1.006	TUBA1B,C9orf72,RRM2B,RAN,FADS3,PTPRC,LTF,CTSS,CSE1L,KEAP1,ATF4,CHCHD2,SLC24A3,CNR1,FLOT1,ANXA2,ELOVL1,CD52,RTN4,TFRC,ALCAM,SQSTM1,CYR61,GSTP1,SCN11A,FTH1,APOE,ADAM17,RPS3A,TCEA1,CHCHD10,DDIT3,HN1,NQO2,BAG6,UCHL1,GBA,TNXB,ANXA5,SCN3A,TOP2A,LY6E,RPL31,SIGMAR1,OAS1,IMPDH2,FCGR2A,TNFRSF1A,EGR1,ACTB,RPL17,TRIB3,SNCG,RNF6,APP,GRN,CALM1 (includes others),FTL,MT-ND1,SREBF2,SREBF1,EIF4A1,PSAP,TSPO,ADRA1A,EEF1A1,PFN1,KCND3,ARL6IP5,MBP,MAP1B,SCN7A,CXCL12,HSPA5,NNMT,SLC25A6,RPL13,COMT,TUBA1C,GSK3B,SPP1,GPS2,CNP,MAGED2,FIG4,BCL2L1,ADRA2A,MAPT,CAPN2,RPL13A,POLE3,MT-TP,PEBP1,SUMO3,SLC1A4,HIGD1A,COPE,EPSTI1,FAS,NELFE,FARSB,HLA-G,PARK7,KCNMA1,STUB1,ERBB4,MCAM,ANXA1,ATP13A2,PRNP,CAPZB,GABBR1,DNAJC1,SOD1,ATP6V1E1,MT-ND5	116	
Cellular Movement	invasion	invasion of cells	1.02E-11	Increased	4.898	bias	1.510	NPM1,CTGF,WHSC1,HRAS,SLC9A1,ODC1,BCAT1,LGMN,PTP4A2,LTF,CSE1L,CTSS,KEAP1,TMSB10/TMSB4X,KLF8,ZBTB16,WNT5B,AHCY,LCP1,BIRC7,CNR1,PTP4A3,FGFR2,ANXA2,JUNB,HMGA1,ROR1,HAX1,BSG,FSCN1,CTSB,ALCAM,SFRP1,SQSTM1,CYR61,FH,ESR2,ALK,NME1,ADAM17,HTATIP2,RALA,GBP1,DUSP6,GDF15,ADIPOQ,FKBP1A,PROX1,RUVBL1,CDH11,ENAH,ARF6,HSP90AB1,PHB,RHOD,PRKCE,DAB2,SERPINA1,NFE2L2,PLOD3,PLAT,CD53,PTPRK,PPIF,EGR1,GNA12,THAP11,IPO7,SNCG,CYP1B1,APP,GRN,FOS,ITGB2,NTRK3,CSF1,TREM2,NR4A1,WBP2,ARHGDIA,SOX9,PLAU,BMP6,ID4,GAB2,TRAF3,PTPN23,SEPT9,UNC5B,RACK1,NME2,CXCL12,SDC4,HSPA5,CBX5,CTBP1,CTSD,RHOG,ENTPD5,ITGAV,GSK3B,GPC1,C1QBP,RET,SPP1,FST,HDAC2,GSDMB,HNRNPAB,CITED1,KLF4,SEL1L,BCL2L1,SDCBP,ADRA2A,ADAM12,CDC42,LIMA1,NUAK1,CD14,CAPN2,TFPI,TMEM176B,RPSA,ETV5,CD151,PEBP1,SULF1,ATP6V0C,GEM,LEP,PLGRKT,PDGFA,MMP14,PKM,HIF1A,FAS,CLCN4,HMOX1,SHC1,PSMD10,CCDC88A,PARK7,CSPG4,THBS1,DKK3,FLNA,KCNMA1,ANXA1,MCAM,ERBB4,SAA1,TGFB2,RNH1,RHOBTB2,MAPKAPK2,PI4KB,LASP1,ADAMTS15,CALR,VCAM1,TP63,EDNRB,BHLHE41,VANGL1,NQO1,MGAT5,CEBPB,SERPINE2,CAPNS1,LPAR1,PAG1,CHI3L1,ADAM9,MAP4K4,MMP9	176	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of leukocytes	1.03E-11	Increased	2.855	bias	-0.387	NPM1,CTGF,CTSG,HRAS,CHST2,PTPRC,SGPL1,LTF,CTSS,ABCC1,TXN,GNA13,AIF1,TMSB10/TMSB4X,ZBTB16,LCP1,CNR1,FLOT1,ANXA2,NINJ1,YARS,MS4A4A,RTN4,CTSB,IL10RA,ALCAM,SFRP1,PLTP,CYR61,ADCYAP1,C3AR1,ESR2,APOE,ADAM17,DAPK2,HLA-A,PRDX1,NQO2,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,G6PC3,LIPA,CES1,GBA,SERPINA1,STIM1,NFE2L2,GJB2,PLAT,IL11RA,RPS19,CD209,UCP2,TYROBP,TNFRSF1A,FCGR2A,ACTB,GNA12,ALOX5AP,PVR,APP,GRN,FOS,ITGB2,MT-ND1,EDIL3,GLIS2,CSF1,DOCK8,SREBF1,TREM2,FCER1G,NR4A1,PLAU,NAB2,SOCS3,PLCB2,PLP1,PFN1,CMA1,CD4,UNC5B,CXCL12,CD63,CD28,NARS,CXCL14,CYBB,ITGAV,NEO1,STAB1,C1QBP,KLF2,FERMT3,PTX3,SPP1,KCNK2,CNP,CAPG,FYB,SMPD2,TPSAB1/TPSB2,EFS,CDC42,DUSP1,IL1RN,SH2B3,IGFBP3,MAPK10,CD14,SIRPA,RPL13A,CD151,LITAF,LEP,MSR1,PPIB,PYCARD,MMP14,CFTR,HIF1A,FAS,TACR1,HLA-G,HMOX1,SHC1,CCDC88A,THBS1,FLNA,ANXA1,MCAM,EFNB1,DUSP10,SAA1,TGFB2,KIT,EGLN3,MAPKAPK2,PRNP,SEMA3E,CALR,VCAM1,EDNRB,NQO1,MGAT5,HYAL1,TRPA1,HSPD1,NFKBIZ,PLXND1,CSF1R,CXCL16,TNFAIP8L2,C6,NCKAP1L,MMP9	159	
Cardiovascular Disease	peripheral vascular disease	peripheral vascular disease	1.24E-11	 	1.140	 	1.605	RAP2B,ADAMTS8,APOB,BAG3,MARK1,CXCL12,VWA5A,NPC1L1,SLC9A1,NPL,CECR1,NNMT,HSPA4,CTSS,CYBB,IFI30,PLEKHO2,ITGAV,TUBA1C,UNG,GULP1,LCP1,TBC1D2B,SPP1,LAIR1,CNR1,TUBB2A,KCNK2,CAPG,POLR2K,FYB,KLF4,RPL9,NGRN,LMCD1,CTSA,ADRA2A,VKORC1,MAPT,BTG2,CTSB,EBNA1BP2,IRF8,PLTP,TFPI,C3AR1,TMEM176B,FTH1,APOE,HTATIP2,RAB4A,LAPTM5,MSR1,ARL4C,HYOU1,EEF1B2,ADIPOQ,ADAP2,CD83,HIF1A,FAS,TNFRSF12A,COL6A1,UST,THBS1,F5,TGFB2,SNX10,LOC102724428/SIK1,DAB2,SEMA3B,PLAT,PRNP,CD53,VCAM1,UCP2,TNFRSF1A,TUBB4B,FCGR2A,HSPH1,TUBG1,SLC6A6,ALOX5AP,F13A1,VSIG4,PLXND1,APP,LPAR1,TPP1,P2RY12,MAP4K4,ADRA1A,MMP9	93	
Cancer, Organismal Injury and Abnormalities	metastasis	metastasis	1.30E-11	Increased	3.168	 	1.984	NPM1,CTGF,HRAS,GYG2,RPS11,PTPRC,POR,DGCR6L,LTF,CSE1L,TMSB10/TMSB4X,KLF8,PTP4A3,GSTM3,TUBB2A,FGFR2,HMGA1,ROR1,HAX1,ISLR,CCND2,FSCN1,CTSB,ALCAM,GLUL,MAP2K3,DUSP4,SFRP1,SQSTM1,CYR61,SETBP1,PDCD5,ESR2,STEAP3,GSTP1,ALK,S100A11,APOE,NME1,MSC,ADAM17,HTATIP2,TCEA1,NID2,DUSP6,HMGN1,GDF15,HYOU1,LGALS9,PPIA,FKBP1A,PROX1,ENAH,ARF6,HSP90AB1,PHB,ANXA5,TOP2A,PRKCE,SERPINA1,STIM1,SMPD3,MYL12A,PLAT,PLOD2,IMPDH2,FCGR2A,TUBB4B,ACTB,GNA12,SNCG,CYP1B1,FOS,FTL,CSF1,USP22,EIF4A1,PSAP,P2RY12,PLAU,ABCC3,NCAM1,EEF1A1,SOCS3,SLC7A11,AKR1C3,RACK1,CXCL12,RNASE1,TUBB,NR2F1,CD28,HOXA10,ITGAV,IFI30,CYBB,STAB1,ANXA7,TUBA1C,C1QBP,RET,CLCN3,PTX3,SPP1,FST,HDAC2,FSTL3,KCNK2,CDK6,HNRNPAB,SLC12A7,CAPG,LMCD1,EFS,BCL2L1,CD3G,PPP2R1A,SDCBP,ADAM12,IL1RN,NUAK1,CAPN2,TFPI,POLE3,CD151,SCD,ERAP2,SRPX,EPB41L3,PDGFA,MMP14,HIF1A,FAS,TNFRSF12A,HMOX1,PSMD10,CCDC88A,THBS1,FLNA,ANXA1,MCAM,ERBB4,TGFB2,LOC102724428/SIK1,KIT,RNH1,HCST,ALPL,PRNP,SEC61G,VCAM1,NDUFB4,AKR1C1/AKR1C2,TP63,EDNRB,BHLHE41,TUBG1,SLC5A3,CSF1R,NDUFA13,ATIC,FGF1,EMP1,CLGN,TNFAIP8L2,ADAM9,MMP9	167	
Cardiovascular Disease	peripheral arterial disease	advanced stage peripheral arterial disease	1.58E-11	 	 	 	 	RAP2B,APOE,HTATIP2,ADAMTS8,LAPTM5,MSR1,ARL4C,BAG3,CXCL12,MARK1,ADAP2,VWA5A,CECR1,HSPA4,COL6A1,UST,THBS1,CTSS,TGFB2,SNX10,IFI30,PLEKHO2,DAB2,SEMA3B,GULP1,CD53,LCP1,TBC1D2B,UCP2,SPP1,LAIR1,HSPH1,VSIG4,CAPG,FYB,PLXND1,LMCD1,NGRN,CTSB,TPP1,IRF8,MAP4K4,C3AR1,FTH1	44	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of tumor cells	1.58E-11	Decreased	-5.428	 	-4.344	RAN,HRAS,RPS11,CCND3,CSE1L,KEAP1,TXN,CAPN6,BIRC7,LAIR1,ANXA2,BSG,PSMA5,CTSB,RTN4,PSMA4,EBNA1BP2,SFRP1,CYR61,PHLPP1,DDIT3,RPS3A,GDF15,ADIPOQ,HSPB8,LGALS9,CDH11,SMARCA4,RPL35,HSP90AB1,PRKCE,SNRPD3,RPS12,RPS5,RPL31,NFE2L2,RPS24,RPS19,APP,COPG1,EIF3G,FOS,RPS16,CSF1,NR4A1,CYCS,RPL37,PLAU,BMP6,SOCS3,GAB2,PNO1,EEF1A1,SLC7A11,RACK1,CXCL12,VDAC2,CD28,RPL13,RPS13,ITGAV,RPL19,SNRPD1,HOXA7,GSK3B,PSMB5,HSPA9,CDK6,PSMC4,RPL37A,RPL9,BCL2L1,ADAM12,IGFBP3,RPL13A,UBE2I,SFRP2,LEP,UGCG,HIF1A,RPL7A,FAS,HMOX1,ANXA1,EGLN3,KIT,PSMA3,SEMA3B,RPS3,PRNP,VCAM1,MAP3K1,RPS21,SOD1,RPS29,FAU,ENO1,RPS4Y1,LPAR1,SLC16A1,MMP9,RPLP0,RPL38	103	
Protein Synthesis	expression	expression of protein	1.85E-11	 	-0.737	 	-0.514	EEF1A1,GAB2,RACK1,OGFOD1,HSPA5,MRM2,PTPRC,EIF4G2,PABPC4,EIF5,RPL19,ETF1,GPC1,EIF2AK1,SPP1,NANOS1,DKC1,MT-TC,EIF2B3,JUNB,EIF4E2,MARS,EPRS,MRPL17,MAPT,BTG2,GAPDH,MAP2K3,EIF5A,RPL41,RPL13A,CNBP,EIF3K,MT-TP,PHLPP1,RPL24,LEP,RPS3A,MMP14,SLC7A1,EIF2S1,HNRNPK,MT-TN,FAS,FARSB,THBS1,ANXA1,MT-TS1,ARHGEF2,RPS5,SARS,RPS3,SMPD3,MT-TD,PRNP,RPS24,PATL1,CALR,TP63,MT-TY,RPL17,RPL30,DNAJC1,SOD1,RPS29,CPEB4,APP,EIF3G,FOS,RPS4Y1,WARS,MRPL51,MRPS7,CSF1,EIF4A1,RPS27L,RPL37,MT-RNR1,CPEB1,RPL38	80	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of cancer cells	2.02E-11	Decreased	-4.818	 	-3.563	EEF1A1,PNO1,GAB2,SOCS3,RAN,CXCL12,RPS11,VDAC2,CD28,RPL13,RPS13,CSE1L,KEAP1,RPL19,ITGAV,HOXA7,SNRPD1,TXN,GSK3B,CAPN6,PSMB5,LAIR1,HSPA9,PSMC4,CDK6,RPL37A,RPL9,BCL2L1,PSMA5,PSMA4,RTN4,IGFBP3,CTSB,EBNA1BP2,SFRP1,CYR61,RPL13A,UBE2I,SFRP2,LEP,RPS3A,DDIT3,GDF15,ADIPOQ,HSPB8,LGALS9,HIF1A,RPL7A,SMARCA4,FAS,HMOX1,RPL35,HSP90AB1,ANXA1,KIT,EGLN3,PRKCE,PSMA3,SNRPD3,SEMA3B,RPS12,RPS5,RPS3,NFE2L2,RPL31,PRNP,RPS24,RPS19,VCAM1,MAP3K1,RPS21,SOD1,RPS29,FAU,COPG1,APP,EIF3G,FOS,ENO1,RPS4Y1,RPS16,LPAR1,CSF1,SLC16A1,NR4A1,RPL37,BMP6,MMP9,RPLP0,RPL38	90	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	necrosis	necrosis of tumor	2.62E-11	Decreased	-5.428	 	-4.344	RAN,HRAS,RPS11,CCND3,CSE1L,KEAP1,TXN,CAPN6,BIRC7,LAIR1,ANXA2,BSG,PSMA5,CTSB,RTN4,PSMA4,EBNA1BP2,SFRP1,CYR61,PHLPP1,DDIT3,RPS3A,GDF15,ADIPOQ,HSPB8,LGALS9,CDH11,SMARCA4,RPL35,HSP90AB1,PRKCE,SNRPD3,RPS12,RPS5,RPL31,NFE2L2,RPS24,RPS19,APP,COPG1,EIF3G,FOS,RPS16,CSF1,NR4A1,CYCS,RPL37,PLAU,BMP6,SOCS3,GAB2,PNO1,EEF1A1,SLC7A11,RACK1,CXCL12,VDAC2,CD28,RPL13,RPS13,ITGAV,RPL19,SNRPD1,HOXA7,GSK3B,PSMB5,HSPA9,PSMC4,CDK6,RPL37A,RPL9,BCL2L1,ADAM12,IGFBP3,NUAK1,RPL13A,UBE2I,SFRP2,LEP,UGCG,HIF1A,RPL7A,FAS,HMOX1,ANXA1,EGLN3,KIT,PSMA3,SEMA3B,RPS3,PRNP,VCAM1,MAP3K1,RPS21,SOD1,RPS29,FAU,ENO1,RPS4Y1,LPAR1,SLC16A1,MMP9,RPLP0,RPL38	104	
Cardiovascular Disease	peripheral arterial disease	intermediate disease stage peripheral arterial disease	2.88E-11	 	 	 	 	RAP2B,APOE,RAB4A,LAPTM5,ARL4C,EEF1B2,CXCL12,CD83,VWA5A,CECR1,THBS1,CTSS,TGFB2,IFI30,PLEKHO2,LOC102724428/SIK1,DAB2,SEMA3B,GULP1,CD53,LCP1,UCP2,TBC1D2B,SPP1,LAIR1,FCGR2A,VSIG4,CAPG,POLR2K,FYB,KLF4,PLXND1,RPL9,NGRN,CTSA,LPAR1,BTG2,CTSB,TPP1,EBNA1BP2,IRF8,PLTP,MAP4K4,C3AR1,TMEM176B	45	
Cancer, Organismal Injury and Abnormalities	benign connective or soft tissue neoplasm	benign connective or soft tissue neoplasm	3.03E-11	 	 	 	 	RAP2B,NR6A1,SOCS3,TWF1,PLP1,MEGF9,RPE,AHCYL1,SCN7A,MAF,HRAS,COL8A1,MRVI1,NR2F1,POR,CXCL14,RPL19,ERAL1,RET,COL27A1,WNT5B,SLC2A5,ALDH1B1,CALCRL,CAPN6,PLD3,SLC24A3,CNP,FGFR2,RAPGEF3,AP2S1,RPL9,KCNG1,CCND2,ADRA2A,ADAM12,DUSP1,PRKACA,ALDOA,SFRP1,CYR61,FH,ESR2,FTH1,S100A11,UQCRH,PHLDA2,SCARA5,RBBP8,UGCG,SLC7A1,FKBP1A,COL15A1,FAS,COL16A1,SHC1,COL6A1,HSP90AB1,ERBB4,TOP2A,KIT,MICALL1,RPS19,COL5A2,DLGAP4,EDNRB,EGR1,DVL1,HYAL1,GABBR1,SLC5A3,CSF1R,STXBP6,CYP1B1,FOS,RPS15,PLCB4,COL5A3,CSF1,SLC33A1,NR4A1,NR5A2,ATP6V1B2,ADRA1A,CLUH	85	
Cell Death and Survival	cell viability	cell viability	3.79E-11	Increased	6.343	bias	0.429	WHSC1,ASS1,RRM2B,SLC9A1,POR,PTPRC,IP6K3,LTF,MCOLN3,KIF1A,KEAP1,STAM,UNG,MFAP5,PPP1R1B,FGFR2,NPY5R,BTG2,PRKACA,CTSB,PSMA4,SQSTM1,ADCYAP1,ESR2,FTH1,APOE,NME1,HTATIP2,DDIT3,GDF15,ADIPOQ,HSPB8,PPIA,SMARCA4,SYNM,OGT,HSP90AB1,DAB2,BCAP31,ALPK2,NFE2L2,SIGMAR1,MECOM,TNFRSF1A,POLDIP2,FOS,NTRK3,CSF1,EIF4A1,NR4A1,PSAP,SOX9,ABCC3,BMP6,ID4,SOCS3,TRAF3,PCDH18,SEPT9,MBP,RACK1,BAG3,TYMP,HSPA5,CD28,PACS2,NUPR1,SNRPD1,HDAC2,PFDN5,AURKAIP1,PPP1R11,KLF4,BCL2L1,DUSP1,XRCC6,IGFBP3,CAPN2,TFPI,PPAT,UBE2I,RPSA,SULF1,SCD,TFEB,CARS,MSR1,PYCARD,PCDHGB4,MLH1,IRAK1,HLA-G,SHC1,MED15,MCAM,ATP13A2,HSPB6,VCAM1,TP63,USMG5,NPY1R,MGAT5,SOD1,HSPD1,PSME3,FGF1,KIFC3,CHI3L1,APOB,CTGF,HRAS,NCSTN,SGPL1,PTP4A2,ABCC1,TXN,BIRC7,PTP4A3,ELOVL1,HMGA1,ROR1,VKORC1,MBD4,SFRP1,TCF7,CYR61,FH,GSTP1,PHLPP1,ALK,ADAM17,ATP5H,UBQLN1,DUSP6,HMGN1,HYOU1,KAZN,ASNS,UCHL1,LYZ,PHB,ANXA5,PRKCE,NACC1,FKBP5,IL11RA,PLAT,PTPRK,TYROBP,TRIM28,EGR1,CASK,APP,ITGB2,SREBF2,PPP1R16B,DOCK8,FCER1G,PLAU,NCAM1,GAB2,PRPF19,SLC31A1,PLP1,PTPN23,CCNI,CD4,UNC5B,CXCL12,METAP2,CTBP1,CAMK2D,PLCE1,DPP3,ITGAV,CYBB,POMP,GSK3B,GPC1,RET,BCKDK,RAD51C,KLF2,SLC6A8,SPP1,ANLN,PHB2,PSMC4,CDK6,CDK2AP1,TIE1,SEL1L,OSTM1,PPP2R1A,CDC42,IL1RN,MAPT,MAPK10,NUAK1,RARRES3,VDAC1,SFRP2,LEP,ATF5,PDGFA,PKM,SLC7A1,UGCG,HIF1A,FAS,CLCN4,HMOX1,HINT1,NLK,PARK7,FLNA,THBS1,DUSP10,ERBB4,EFNB1,TGFB2,KIT,TCP1,EGLN3,PSMA3,SELENOH,MAPKAPK2,PRNP,CALR,MAP3K1,CEBPB,CSF1R,NDUFA13,THRSP,ENO1,SLC16A1,EPHB3,PPP2R1B,MMP9,SHMT2,RPL38	241	
Cancer, Organismal Injury and Abnormalities	metastatic carcinoma	metastatic carcinoma	4.61E-11	 	 	 	 	S100A11,EEF1A1,SCD,MMP14,PPIA,FKBP1A,RNASE1,HIF1A,FAS,RPS11,PTPRC,POR,HSP90AB1,CSE1L,ERBB4,TOP2A,IFI30,KIT,PRKCE,TUBA1C,RET,TMSB10/TMSB4X,CLCN3,KLF8,MYL12A,SEC61G,NDUFB4,SPP1,TUBB4B,TUBG1,TUBB2A,CDK6,FGFR2,SLC12A7,CSF1R,ATIC,BCL2L1,FTL,CSF1,EIF4A1,DUSP4,SFRP1,PLAU,ABCC3,ESR2,POLE3,ALK	47	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of phagocytes	5.18E-11	Increased	2.195	bias	-1.055	NPM1,CTGF,CTSG,HRAS,CTSS,ABCC1,TXN,AIF1,TMSB10/TMSB4X,CNR1,FLOT1,ANXA2,NINJ1,MS4A4A,RTN4,IL10RA,CTSB,ALCAM,PLTP,SFRP1,CYR61,ADCYAP1,C3AR1,APOE,ADAM17,DAPK2,NQO2,ADIPOQ,PPIA,G6PC3,CES1,GBA,SERPINA1,STIM1,NFE2L2,GJB2,IL11RA,PLAT,RPS19,CD209,TYROBP,TNFRSF1A,FCGR2A,ALOX5AP,PVR,APP,GRN,ITGB2,MT-ND1,EDIL3,GLIS2,SREBF1,DOCK8,CSF1,TREM2,FCER1G,PLAU,NAB2,SOCS3,PLCB2,PLP1,PFN1,CD4,UNC5B,CXCL12,CD28,NARS,CXCL14,ITGAV,CYBB,STAB1,C1QBP,PTX3,SPP1,CNP,CAPG,TPSAB1/TPSB2,CDC42,DUSP1,IL1RN,SH2B3,CD14,SIRPA,RPL13A,CD151,LITAF,LEP,MMP14,CFTR,HIF1A,FAS,TACR1,HMOX1,CCDC88A,FLNA,THBS1,ANXA1,DUSP10,SAA1,EFNB1,MCAM,TGFB2,KIT,EGLN3,MAPKAPK2,PRNP,SEMA3E,VCAM1,EDNRB,NQO1,HYAL1,MGAT5,NFKBIZ,PLXND1,CSF1R,TNFAIP8L2,C6,NCKAP1L,MMP9	119	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis	1.03E-10	Decreased	-2.153	bias	-0.211	APOE,PLP1,ADIPOQ,SH3GLB1,CERS2,PRKCE,GSK3B,HPGDS,CLCN3,NFE2L2,ATP13A2,NDUFS4,ACP2,PSMC4,NR1H3,SOD1,ARSA,HAX1,APP,GRN,SLC33A1,TREM2,MAPT,PPT1,CTSB,PSAP,CLCN7,SQSTM1,ESR2	29	
Free Radical Scavenging	metabolism	metabolism of reactive oxygen species	1.06E-10	 	1.130	 	-0.711	CTSG,HRAS,TMBIM6,SCO2,LTF,ABCC1,TXN,CD52,RTN4,TFRC,MAP2K3,SQSTM1,ADCYAP1,CYR61,ESR2,C3AR1,GSTP1,FTH1,APOE,DDIT3,UBQLN1,PRDX1,ADIPOQ,PPIA,RPL26,LIPA,HSP90AB1,PHB,PRKCE,SERPINA1,TPO,NFE2L2,SIGMAR1,LETM1,UCP2,FCGR2A,TNFRSF1A,TYROBP,ACTB,CYP1B1,CSTB,APP,GRN,ITGB2,FOS,FTL,IMMT,SREBF2,SREBF1,CSF1,NR4A1,CYCS,ARHGDIA,PLAU,GABARAP,GAB2,SOCS3,TRAF3,PLCB2,RACK1,CXCL12,CD28,ALDH3A2,CXCL14,CYBB,UQCRFS1,CLCN3,HK1,SPP1,SESN3,HSPA9,RPL29,RAPGEF3,THRA,SDHC,ARSA,TXNRD1,BCL2L1,CDC42,DUSP1,TXN2,MAPT,CD14,AKR1B1,VDAC1,PTGFR,LEP,MSR1,PRDX5,MMP14,FAS,HNRNPK,IRAK1,SHC1,HMOX1,PARK7,ANXA1,CYGB,SHANK2,OGDH,LONP1,HSPB6,PRNP,MT-CO1,VCAM1,NQO1,SOD1,TNFAIP8L2	108	
Gene Expression, Protein Synthesis	translation	translation of RNA	1.41E-10	Decreased	-2.747	bias	 	RACK1,OGFOD1,EIF4G2,PABPC4,EIF5,RPL19,ETF1,EIF2AK1,NANOS1,EIF2B3,MT-TC,EIF4E2,EPRS,MRPL17,BTG2,GAPDH,RPL13A,RPL41,MT-TP,EIF3K,RPL24,RPS3A,EIF2S1,MT-TN,FARSB,MT-TS1,SARS,RPS3,RPS5,MT-TD,RPS24,PATL1,CALR,MT-TY,RPL17,RPL30,DNAJC1,RPS29,APP,EIF3G,RPS4Y1,WARS,MRPL51,MRPS7,RPS27L,RPL37,CPEB1,MT-RNR1,RPL38	49	
Neurological Disease	neurodegeneration	Neurodegeneration	1.57E-10	Decreased	-4.602	bias	-1.323	PLP1,VAC14,SLC9A1,CERS2,CTSD,GLB1,LYNX1,KIF1A,CYBB,MTMR2,GSK3B,RET,CLCN3,UNG,STXBP1,PTPRQ,CNR1,CNP,ASNA1,SLC12A7,NR1H3,SLC4A7,FGFR2,THRA,ARSA,SH3GL1,BCL2L1,DNAJC5,IL1RN,MAPT,CTSB,GAPDH,NAGLU,CLCN7,LRP8,SQSTM1,ESR2,SORL1,APOE,RAB1A,UBQLN1,ADIPOQ,UGCG,HIF1A,MAFG,UCHL1,GBA,PARK7,STUB1,KCNMA1,TGFB2,TUB,NFE2L2,NDUFS4,PLAT,PRNP,EDNRB,TYROBP,MGAT5,SOD1,CSF1R,ZPR1,NFE2L1,FGF1,APP,GRN,FTL,NTRK3,SLC33A1,PPT1,TPP1,PSAP,C6,NCAM1	74	
Free Radical Scavenging	synthesis	synthesis of reactive oxygen species	1.66E-10	 	0.633	 	-1.057	CTSG,HRAS,TMBIM6,SCO2,LTF,ABCC1,CD52,RTN4,TFRC,MAP2K3,SQSTM1,ADCYAP1,CYR61,ESR2,C3AR1,GSTP1,FTH1,APOE,DDIT3,UBQLN1,PRDX1,ADIPOQ,PPIA,RPL26,LIPA,HSP90AB1,PHB,PRKCE,SERPINA1,TPO,NFE2L2,SIGMAR1,UCP2,LETM1,FCGR2A,TNFRSF1A,TYROBP,ACTB,CYP1B1,CSTB,APP,GRN,ITGB2,FOS,FTL,IMMT,SREBF2,SREBF1,CSF1,NR4A1,ARHGDIA,PLAU,GABARAP,GAB2,SOCS3,TRAF3,PLCB2,RACK1,CXCL12,CD28,ALDH3A2,CXCL14,CYBB,UQCRFS1,CLCN3,HK1,SPP1,SESN3,HSPA9,RPL29,RAPGEF3,THRA,SDHC,ARSA,TXNRD1,BCL2L1,DUSP1,CDC42,TXN2,MAPT,CD14,AKR1B1,VDAC1,PTGFR,LEP,MSR1,MMP14,FAS,HNRNPK,IRAK1,SHC1,HMOX1,PARK7,ANXA1,OGDH,SHANK2,LONP1,HSPB6,PRNP,MT-CO1,VCAM1,NQO1,SOD1,TNFAIP8L2	104	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	mammary tumor	mammary tumor	1.66E-10	 	1.999	 	1.406	ADAMTS8,WHSC1,KCMF1,COL8A1,ODC1,CLIP1,POR,IP6K3,CCND3,EIF4G2,CSE1L,KEAP1,ATF4,DGKG,GNA13,SYT17,ALDOC,MRPL24,SRPRA,PPP1R1B,FGFR2,HAX1,NRBP1,CTSA,SCUBE1,FSCN1,BTG2,PSMA5,GPR65,DUSP4,NHLH1,ESR2,STEAP3,FTH1,EIF3K,EPHX1,APOE,NME1,HTATIP2,PRDX1,BAG6,HSPB8,ADIPOQ,PROX1,ATRAID,MMP25,COL16A1,RABL6,HSP90AB1,TNXB,FBXW11,PLIN2,ATP5J2,DAB2,NFE2L2,RPL4,MECOM,TUBB4B,GNA12,SLC39A6,ZNF362,C1orf122,FOS,MT-ND1,AFF3,NTRK3,CSF1,EIF4A1,NR4A1,ARHGDIA,SOX9,AKR1C3,SEPT9,NME2,TYMP,HSPA5,GPC3,BIN1,CTSD,FAM117B,CXCL14,FAR2,TUBA1C,CDC42EP1,ADAMTS5,PFKFB3,FSTL3,KCNK2,TMC5,PGAP3,FYB,KLF4,FOSB,BCL2L1,ADRA2A,ADAM12,DUSP1,RBX1,LIMA1,LSM1,IGFBP3,UHRF1BP1L,MEGF8,CBX3,POLE3,CD151,SULF1,MSR1,PLGRKT,MECR,PCDHGB4,PKHD1L1,REXO2,HLA-G,SHC1,PSMD10,F8,MCAM,LOC102724428/SIK1,RHOBTB2,IGSF8,RPS3,DNAAF1,LONP1,WDR1,MT-CO1,PATL1,TP63,AKR1C1/AKR1C2,NPY1R,TUBG1,HPS1,NQO1,SOD1,NFE2L1,FGF1,CISD1,CLGN,NOP16,MUC17,SLC25A5,CHI3L1,TUBA1B,THEMIS2,CPAMD8,CTGF,APOB,LDB3,HRAS,GYG2,VWA5A,MKI67,CECR1,BCAT1,PRG4,MPV17L2,ABR,ABCC1,KLF8,WNT5B,GSTM3,TUBB2A,ZNF592,NR1H3,JUNB,KIAA0100,FARSA,NUGGC,CCND2,CD68,BSG,C19orf53,MS4A4A,STIP1,RMND1,RTN4,ALDOA,ARHGAP35,CCT3,GLUL,MAP2K3,CDK2AP2,SFRP1,AIDA,TCF7,CYR61,SETBP1,PDCD5,MYEOV,GSTP1,ALK,SORL1,ADAM17,GSTM5,NID2,HLA-A,UBQLN1,NQO2,CDK16,XPOT,FKBP1A,CCAR2,PFKL,DCLK1,H2AFZ,TAX1BP3,CDH11,ENAH,FANCE,UCHL1,RPL35,NDUFB9,CES1,GBA,PHB,UST,IFRD2,MT-CYB,TOP2A,TRIM16,TUB,TPO,FKBP5,SLC30A1,GJB2,LIMCH1,LAMB4,PLOD3,COX4I1,PLAT,RPS24,RPS19,NAP1L4,DNAH12,LETM1,ADRM1,EGR1,ATXN2L,COPS3,EIF3G,FIS1,CALM1 (includes others),COL5A3,SUPV3L1,SREBF2,SREBF1,CYCS,DVL3,CBX4,PLAU,MAPRE3,GAB2,PFN1,CD4,CXCL12,UTP4,TUBB,METAP2,MTCH2,VDAC2,PAX5,GSPT1,CNDP2,SLC25A6,DPP3,COMT,EIF5,RPL19,ITGAV,SIAH2,GSK3B,C1QBP,RET,DSP,EIF2AK1,IGFBP6,SPP1,GSDMB,GCNT2,LAGE3,CDK6,PSMC4,MAGED2,MARS,PKN1,CD3G,PPP2R1A,MAPK10,AKR1B1,PHF1,AKR7A2,LEP,SFRP2,HIGD1A,ATF5,PRDX5,PDGFA,MMP14,PCDH19,PKM,RBBP8,SLC7A1,CFTR,HIF1A,FAS,NELFE,SLC39A1,HMOX1,CSPG4,THBS1,FLNA,NDUFC2,ANXA1,ERBB4,F5,TGFB2,GSTM4,KIT,TCP1,ARHGEF2,MAPKAPK2,OGDH,ALPL,HMGCS1,PI4KB,NDUFAF3,SEMA3E,ADCY2,TAF6,TPST2,MAP3K1,RNF43,QSOX1,ZBTB7C,GUK1,CEBPB,CSF1R,THRSP,ENO1,MT-ND5,DIP2C,LPAR1,SLC16A1,CYC1,ASAP2,C6,ADAM9,PPP2R1B,SCAND1,SHMT2,MMP9	351	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	malignant solid tumor	2.27E-10	 	0.788	 	1.001	PCLO,VAC14,GARS,LRRN4CL,GNB1,GLB1,GNA13,RNPEPL1,SRPRA,MYL9,NDUFB7,PSMA4,ALCAM,TMEM43,ELMO2,KDM1B,DDIT3,SLC1A5,RABL6,ACSS3,LY6E,MTSS1L,RNF157,AFF3,KIF7,EDIL3,ATP6V1F,DERL1,WBP2,NR4A1,PIGU,AKR1C3,EML4,STRN4,STC2,ANKDD1A,SNRPD1,MTMR2,TUBA1C,NSMAF,WDR93,UBL4A,LSM1,NAGLU,POLD2,ZC3H7B,SCD,CARS,FLRT1,FAT3,C20orf24,COL6A1,IGSF8,LASP1,AKR1C1/AKR1C2,ANKRD20A5P,PYGB,CFAP97,UTY,TBL1Y,RAP2B,GFPT1,CTGF,ITGA8,CA12,SGPL1,ZBTB7B,C9orf91,SLC22A15,ZNF605,FAM124B,PNKD,KLF8,ZBTB16,PTP4A3,CNOT10,NINJ1,ACAD11,ISLR,SCRN1,SNRNP25,NCLN,RMND1,FKBP14,HLA-A,NQO2,LRP6,FKBP1A,CCAR2,RUVBL1,MRPL30,H2AFZ,ATP6AP1,TUB,TXNL1,FKBP5,ACVR1C,LIMCH1,GJB2,CD53,CD209,EGR1,ZFY,COPS3,CALM1 (includes others),C8orf33,AOX1,NCAM1,PNO1,PDZD11,ZBTB47,FAM127B,CHTOP,CNDP2,PTGES2,COMT,GOT1,POLR1A,PSMF1,CLTC,SLC4A7,MAGED2,ATP10A,RPL12,TPSAB1/TPSB2,CYP4A11,FPR3,GEM,FLYWCH2,HINT1,DUSP10,CYGB,TMEM104,EMP1,PLCB4,PAG1,HLTF,IGSF6,PCDHAC1,RRM2B,CLSTN2,SLC35C1,RAB38,CLN6,MRPL24,ICT1,CD52,HAX1,NRBP1,SCUBE1,MRNIP,AARS,TRAPPC5,MRPL37,FKBP2,APOE,NME1,SFXN4,CDH18,C9orf24,ARL4C,SEC23B,ZDHHC11B,PROX1,ATRAID,SDK1,OGT,HSP90AB1,PLIN2,ARFGAP1,ALG8,RPN1,S100A1,SIGMAR1,RPL4,MLF2,SLC39A6,DGAT2,YPEL1,SNCG,CPEB4,NTRK3,SERPINH1,EIF4A1,BTF3L4,C6orf62,ARHGDIA,PPIL1,ID4,BZW2,MEGF9,USP5,TMEM8A,SLC41A3,PPFIBP2,MRPL47,NME2,RNASE1,SLC35F6,MRM2,C3orf17,CEBPG,CD28,TMEM132C,MOCOS,HOXA10,PACS2,HOXA7,DPM3,GULP1,PFKFB3,FSTL3,RERG,CMSS1,ARSA,DNAJC5,XRCC6,TXN2,ALDH1A2,UHRF1BP1L,CALHM2,RAB4A,AUP1,ME1,FYTTD1,DNAJC4,ZNF483,ACAD8,RHOBTB2,RPS3,IARS,FAM171B,AGFG1,DCTN3,MGAT5,PSME3,FAM49A,DEGS1,NFE2L1,KDM5D,TBC1D7,CHI3L1,SPCS1,PMVK,MAF,SH3GLB1,PCDH7,C1QB,KPNA1,DYNLL1,ABR,ABCC1,GSTM3,PDRG1,NR1H3,STOML2,TSPAN33,ZNF414,CLN5,SERINC2,NUGGC,MS4A4A,MS4A7,PSMB10,CDK16,CTNNA1,KAZN,DCLK2,IFRD2,SRGAP1,TBC1D12,PRKCE,NACC1,YIPF2,PLOD3,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,MRPL51,CLDN5,DOCK8,ADCK2,PRMT5,P2RY12,GAB2,PLP1,CYBB,ADPRHL2,KLHL11,LMO4,SGCG,PSMC4,PLEKHH2,IL1RN,STXBP5,PHF1,PRDX5,EPSTI1,FAM47E,GANAB,FLNA,GSTM4,BHMT2,SEMA3E,CENPV,C10orf71,DLGAP4,AP3D1,F13A1,CCDC58,AHCYL2,MKNK2,CSF1R,ARHGEF10L,TNFAIP8L2,ITPA,PANK3,CLDN2,ATP6V1B2,CARM1,REM1,TMEM184B,NPAS2,GPR55,SPRY4,CCND3,CSE1L,DGKG,KNSTRN,AHCY,YWHAG,HCFC1R1,LAIR1,SURF1,PRKACA,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,FTH1,EVA1B,HTATIP2,PSMD7,DAPK2,BAG6,DPM2,SMARCA4,COL15A1,FKBP3,PLOD2,OAS1,UCP2,MECOM,PTRH1,SLC25A1,RNF6,CSTB,MYO5A,RPS16,CSF1,SEPHS1,SOX9,SLC9A9,GPC3,CTSD,TSEN15,CHMP2A,ERAL1,ADAMTS5,NAGA,STXBP1,SESN3,STK39,UROS,MAPK8IP2,ASNA1,FIG4,CREG1,SMPD2,ADRA2A,TFPI,UBE2I,DDX21,ALG14,SULF1,LITAF,F2RL3,HABP4,PCDHGB4,ZNF219,ALAS1,FILIP1,FARSB,RPL18A,CRYM,PATL1,PREB,TRIM55,CSRNP1,TSN,APLP2,C7orf43,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,MKI67,EIF6,GSS,RPS11,RAD23A,BBS1,AHSA1,LGMN,DUSP3,MPV17L2,POU6F2,MGAT4B,MED16,SYT2,TESK1,CAPN6,DPY19L1,DKC1,JUNB,COPB1,ROR1,BCAP29,TSR3,FARSA,INPP4B,C19orf53,FNDC1,RTN4,CCT3,SETBP1,KLHL18,GSTM5,BTG3,PPP1R3C,TTLL4,HYOU1,GPC4,ASNS,EAF1,CDH11,SDCCAG3,NDUFB9,CES1,PHB,DCXR,PGAM1,MYO1D,NPTXR,MYL12A,PLXNA1,PTPRK,NOL6,DDX3Y,PAICS,TIAL1,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,CCDC85B,SLC48A1,SLC25A11,RHBDD2,SREBF1,BMF,USP22,TREM2,APOL4,NAB2,KCND3,UBE2A,HIST1H2BC,ARF1,PRMT3,CD4,MAP1B,UNC5B,MYH15,CD63,SLC25A6,CAMK2D,PABPC4,CDON,PCYT2,ANXA7,C1QBP,GPC1,GSK3B,RET,MRPS15,DSP,MFSD3,HK1,TRIOBP,GSDMB,XYLT1,TALDO1,GNG2,DGKE,HIST1H2BK,GPAA1,UBXN11,NUAK1,CD14,EIF5A,CLCN7,PLEK,DNPEP,SPIRE1,CREBL2,ARL2,SRM,TOLLIP,RAB1A,SFRP2,KIAA1191,ATF5,ILF2,CD83,RRAGD,HSPE1,OAZ1,WSB2,OGDH,ATP5I,ADAMTS15,BHLHE41,HSPH1,R3HDM1,OAF,GUK1,IL20RB,PLXND1,P4HA1,CYC1,APOC1,NUCB2,EPHB3,UQCRC1,GRPEL1,ADAM9,KLHDC8B,LRRC59,CTSG,TIGIT,COL8A1,NEXN,PLEKHM2,CLIP1,FADS3,IP6K3,MCOLN3,TMSB10/TMSB4X,TPM3,NPY5R,RASL12,TMEM127,HSPA8,GPR65,BTG2,ATMIN,TMEM33,SCN11A,PPDPF,OSGIN1,MMP25,G6PC3,GRINA,COL16A1,SORBS1,TTC23,STT3B,TMC2,TNFRSF1A,SPTLC3,GRN,FOS,DOPEY2,TTYH3,TSC22D2,C11orf68,ABCC3,SIGLEC6,SGCD,PPIP5K2,PTER,ICMT,OGFOD1,STARD7,NPC1L1,HSPA5,FAM117B,ENTPD5,FAR2,CDC42EP1,LACTB,YWHAB,KCNK2,LAMA2,HNRNPAB,PGAP3,CAPG,KCTD15,DMXL2,KCNG1,CDH20,MRPS2,IRF8,RPSA,DOK5,UBXN1,ATP6V0C,MSR1,SF3B5,COPE,TMEM60,LEO1,REXO2,HNRNPK,SLC19A3,SHC1,PREPL,KIAA0232,SAA1,PPP1R2,TRABD2A,RNH1,LIAS,RAD23B,CAPZB,NPY1R,NDUFV3,PWWP2B,NQO1,TRPA1,LARP6,NRBF2,FGF1,PDAP1,SHB,CISD1,CXCL16,CIDEA,SCARA3,KIF5B,SLC36A1,NOP16,COX5A,EMC3,GXYLT2,SLC29A4,KCNK15,CADM3,APOB,PLIN1,C9orf72,MMEL1,SH3BGRL3,TXNL4A,LDB3,MARK1,HRAS,CECR1,PEG10,ANAPC11,CALCRL,CFL1,SLC24A3,THSD4,TKT,FAM126B,TUBB2A,AASS,CTPS1,CD68,CNTNAP4,MBD4,MAP2K3,SFRP1,TCF7,C3AR1,MYEOV,S100A11,RAB32,LAPTM5,ZNF330,RPS3A,NID2,HMGN1,ADAP2,XPOT,DCLK1,RNF24,UCHL1,FANCE,C1QTNF3,RPL35,ACSM5,SLC2A6,SAMD1,SNX10,TPO,NDUFS4,ADRM1,DTX4,TYROBP,FGD6,ACTB,WDR12,CYP1B1,AREL1,COPG1,EIF3G,PDIA6,PPP1R16B,ADCY1,ARAP1,NR5A2,CBX4,DVL3,ATP5D,UTP4,TUBB,VDAC2,RAB11FIP2,NR2F1,EIF5,PUSL1,SLC7A5,NEO1,IGFBP6,C6orf132,SNRPF,GCNT2,PKN1,TIE1,EPRS,SEL1L,PPP2R1A,ADCYAP1R1,GNL3,VDAC1,TMOD1,RPL13A,CEACAM21,VAPA,RBBP8,SLC7A1,UGCG,STXBP4,HIF1A,NAA10,SOX17,HMOX1,CCDC88A,NLK,CSPG4,ANXA1,F5,SELENOH,ARHGEF2,HMGCS1,STK40,CTDNEP1,ALPL,PI4KB,PRNP,TAF6,CYP27A1,COPS7A,NXPH4,GABBR1,ZBTB7C,NDUFA13,WARS,SLC27A3,RTN3,TIMM13,ASS1,EEF1G,POR,GORASP2,DEFB132,VIT,DCAF12,SYT17,ANXA2,RPH3A,PLAG1,RCC2,CD300C,RCN3,ACTG1,FHL1,GBP1,ADIPOQ,MFSD5,PPIA,SYNM,ALPK2,AMOT,IPO7,PSMB6,MARCKSL1,MTHFD1L,GCSH,BTBD2,RPL37,EEF1A1,DIRAS1,DNAJC15,CBX5,LHFPL2,HS6ST1,ABCB11,ARRDC2,GUF1,BCL2L1,RPL8,RBX1,TMX2,CBX3,ETV5,SUMO3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,F8,GID4,C16orf59,DNAAF1,NDUFB4,SEC61G,SNTB1,SOD1,SAA2,VAT1,RPS15,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,TUBA1B,FAM19A5,ABCC6,LRFN5,PRG4,PXK,GPR26,BIRC7,SV2B,CENPB,KAZALD1,HMGA1,MALSU1,SH3GL1,ARHGAP35,SORL1,ST6GALNAC4,SDC3,RNF185,MAFG,CADM2,UST,MYO5C,MT-CYB,SCN3A,DIP2B,HPGDS,RPS5,SMPD3,RPS24,CCDC68,NAP1L4,RRP1B,SLC25A13,ANKRD9,TRIM28,PSMD8,STS,ATXN10,CLUH,RGMA,SLC27A4,FAM173A,PLCXD3,PLCE1,DPP3,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,ANKMY2,IRX6,LAGE3,RPL29,FAM45A,GALNT13,SLC39A3,TARS,ATP6V1A,TMEM189,YIF1A,UTP11,AKR7A2,HIGD1A,PCDHAC2,PCDH19,CLCN4,MPEG1,SSU72,DKK3,THBS1,ASAP3,TPST2,SZRD1,RPS21,CEBPB,SYNPO2,THRSP,ANO2,RPS27L,NCKAP1L,PPP2R1B,SLC47A1,MPV17,SCFD2,CSTA,CA5B,KCMF1,PANX1,ODC1,NPL,GATAD2A,SRPX2,LTF,COMMD2,HIGD2A,PLEKHO2,SPTB,STAM,MGAT1,GNG12,ALDOC,ALDH1B1,PLD3,MFAP5,CNR1,RPAP3,SMOC2,DCTD,PXDC1,DES,SPATA20,PYGO2,AACS,CYP4B1,GCC1,TFRC,DUSP4,CHD1L,SQSTM1,ESR2,DEAF1,AASDHPPT,FBXO10,SLC4A2,PLXNA3,HN1,CUBN,HS2ST1,GDF15,WDR61,EEF1B2,CRAT,LGALS9,TECR,COPS8,CCT4,PEX10,TNXB,ATP5J2,DAB2,SERPINA1,SNRPD3,NFE2L2,P4HA2,MED20,FUCA2,GNA12,GLRX2,SLC6A6,STON1,LZTS2,THAP11,C1orf122,TBC1D13,MYOC,PSAP,TPP1,BMPER,SIM1,BMP6,ADRA1A,TRAF3,NCDN,TPPP3,ACO2,BAG3,TYMP,CES2,IMP4,MRVI1,BIN1,NNMT,SAE1,RPS13,GDE1,CXCL14,NUPR1,STAB1,PSMB5,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,TRIM35,PSMD3,FOSB,TLN2,SDCBP,ADAM12,MATN2,CCPG1,TMEM176B,POLE3,ERAP2,PTGFR,SLC1A4,SRPX,SCARA5,PYCARD,MECR,SLC38A1,LBHD1,VPS4A,RAP1GDS1,IRAK1,MED15,MCAM,LOC102724428/SIK1,ATP13A2,WDR1,SLC20A1,ECHDC2,VCAM1,EDNRB,ST3GAL6,HSPD1,ATIC,AIFM2,SERPINE2,ATP6V1E1,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,VWA5A,MUC7,CHST2,BCAT1,CTSS,HADHB,RPS2,RIMS3,TMEM9B,ARRDC4,ZNF592,PCK1,KIAA0100,MRPL14,DHRS9,YARS,IL10RA,ALDOA,LRP8,P2RY8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,FOLR2,ACSF2,PFKL,SP2,TAX1BP3,LIPA,MACC1,ANXA5,C11orf24,RPS12,SARS,IL11RA,PLAT,RPS19,C9orf142,URB1,FTL,UQCR10,PEA15,CYCS,RUFY3,MAPRE3,MVD,HOXB5,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,RPL13,ACOT1,IFI30,SIAH2,LPIN2,CLCN3,MRPL43,PTX3,TBC1D2B,SPP1,GPS2,ANLN,MACROD1,GLYAT,ERH,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,HSPA13,MAPK10,ACOT4,UHMK1,AKR1B1,RNPEP,SPX,B3GALT6,LEP,PDGFA,MMP14,SLFN5,PHYH,NLGN4Y,SENP3,HSD11B2,MICALL1,PSMA3,RBM18,UBA5,ADCY2,FRMD1,TMEM126B,RARS2,FAU,ENO1,SLC16A1,OLFML2B,TANGO2,MMP9,SHMT2,NPM1,ADAMTS8,RPE,PPP1R14B,ALPK3,ATG9A,SYPL1,AIF1,SLC2A5,FBXO8,CTSB,NHLH1,ARPC1B,PRDX1,AAK1,FCGR2A,TUBB4B,SPATS2L,PVR,C1orf123,SDF4,SOCS3,PCDH18,SEPT9,DPM1,RABEP1,SCN7A,AP1B1,OSCP1,CCT5,FNDC4,UQCRFS1,C12orf49,C2orf83,HDAC2,CBX6,EIF4E2,FYB,MIIP,TXNRD1,OLA1,SLC7A2,TNS1,PPAT,IGFBP4,PLGRKT,PHLDB2,HLA-G,GTPBP2,KLHL42,HSPB6,MT-CO1,TP63,IPO4,TRIM2,KIF3B,WIPF3,POLR3B,HOXA6,GYG2,EXPH5,KIF21A,AFAP1,CPNE4,ELOVL1,NGRN,ME2,B3GNT5,GSTP1,TMEM11,ENAH,LYZ,TTC7B,TRIM16,SLC30A1,LAMB4,PPIF,LPCAT4,CSRNP2,WDR18,LRRC8D,IMMT,BRINP2,PLCB2,GTF3C6,PFN1,C8orf82,TCEB2,METAP2,GSPT1,ALDH3A2,LYNX1,RPL19,POMP,PHPT1,BCKDK,MDH2,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,ACSL3,HSPA9,CD3G,MAPT,TMEM176A,SH2B3,RARRES3,LFNG,TBC1D16,CNRIP1,SH3RF3,MRPS30,SLC39A1,ERBB4,FMO1,SHANK2,KCTD1,CACNG8,MAPKAPK2,CALR,COL5A2,PHLDA3,RNF43,MAP3K1,VSIG4,MRPS16,KIAA1683,PLBD2,TMEM2,RPS4Y1,C2orf88,ASAP2,GBE1,C6,SEMA4B,PSG2,WHSC1,C1QC,MNAT1,SLC9A1,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,LMX1A,UNG,UXS1,LCP1,PPP1R1B,TMEM201,PPTC7,TIMM8B,FLOT1,FGFR2,COX7A1,NDN,CTSA,TOMM22,FBXW5,FSCN1,PRELP,PSMA5,GAPDH,SLC35B4,STEAP3,CHCHD10,PHLDA2,HSPB8,ARF6,ACTR3,FAM102A,OSBPL11,LURAP1L,CSNK2B,RPP25L,SRA1,ZNF362,ALOX5AP,TRIB3,XIST,HSPA2,GIN1,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,MBD3,CCT7,CSTF3,SESN2,MBP,RACK1,HSPA4,RHOG,MEGF6,GCLM,CHMP1A,BCAS2,C20orf27,GM2A,SRPRB,EIF2B3,RAPGEF3,CITED1,KLF4,SLC25A44,SLC3A2,ALG3,DUSP1,SLC25A39,NDUFA6,LIMA1,IGFBP3,PIK3AP1,CAPN2,MEGF8,SIRPA,CD151,MLH1,NDUFA2,RPL14,TWF2,FAM166A,UBIAD1,LONP1,PSAT1,ZNF358,HPS1,TUBG1,EMD,KIFC3,TTL,MUC17,IVD,FHL5,NR6A1,AHCYL1,SGSH,NCSTN,DGCR6L,GAA,TXN,WNT5B,NANOS1,CPA3,CCND2,BSG,NR1D1,LMOD2,STIP1,GLUL,ADM2,CYR61,ALK,ENOPH1,ADAM17,SLC24A2,MSC,TCEA1,UBQLN1,DUSP6,TTC1,SEC61A1,GBA,ACAP2,TOP2A,HLCS,PSMD14,STIM1,ZNF70,COX4I1,AMFR,MYH1,DNAH12,LETM1,IMPDH2,APP,WARS2,B4GALT2,FIS1,SUPV3L1,SREBF2,GABARAP,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,SDC4,TAF10,MMRN1,MTCH2,CTBP1,SLC29A3,NARS,PGD,ITGAV,RAD51C,KLF2,EIF2AK1,DNASE2,RAB10,CDK6,ST6GALNAC3,LMCD1,EFS,ATP6V0D1,DNAJC18,JTB,RNF165,EPB41L3,KLRD1,PKM,CFTR,LDLRAD3,ERV3-1,FAS,TNFRSF12A,SEPHS2,TACR1,EVC,PCK2,NDUFC2,KCNMA1,EFNB1,TGFB2,TCP1,KIT,NR2F6,HCST,ACTN1,NDUFAF3,TRAF7,COX17,VANGL1,QSOX1,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,MAT2A,USP9Y,SCAND1	1555	
Protein Synthesis	translation	translation of protein	2.44E-10	 	-0.585	 	-0.089	EEF1A1,RACK1,OGFOD1,MRM2,HSPA5,EIF4G2,PABPC4,EIF5,RPL19,ETF1,EIF2AK1,NANOS1,DKC1,MT-TC,EIF2B3,EIF4E2,MARS,EPRS,MRPL17,MAPT,BTG2,GAPDH,EIF5A,RPL41,CNBP,RPL13A,EIF3K,MT-TP,RPL24,RPS3A,SLC7A1,EIF2S1,MT-TN,HNRNPK,FARSB,MT-TS1,SARS,RPS3,RPS5,SMPD3,MT-TD,RPS24,PRNP,PATL1,CALR,MT-TY,RPL17,RPL30,DNAJC1,RPS29,CPEB4,APP,EIF3G,RPS4Y1,MRPL51,WARS,MRPS7,EIF4A1,RPS27L,RPL37,MT-RNR1,CPEB1,RPL38	63	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast cancer	breast cancer	2.92E-10	 	1.689	 	1.405	ADAMTS8,WHSC1,KCMF1,COL8A1,ODC1,CLIP1,POR,IP6K3,CCND3,EIF4G2,CSE1L,KEAP1,ATF4,DGKG,GNA13,SYT17,ALDOC,MRPL24,SRPRA,PPP1R1B,FGFR2,HAX1,NRBP1,CTSA,SCUBE1,FSCN1,BTG2,PSMA5,GPR65,DUSP4,NHLH1,ESR2,STEAP3,FTH1,EIF3K,EPHX1,APOE,NME1,HTATIP2,PRDX1,BAG6,HSPB8,PROX1,ATRAID,MMP25,COL16A1,RABL6,HSP90AB1,TNXB,PLIN2,ATP5J2,NFE2L2,RPL4,MECOM,TUBB4B,GNA12,SLC39A6,ZNF362,C1orf122,FOS,MT-ND1,AFF3,NTRK3,EIF4A1,NR4A1,ARHGDIA,SOX9,AKR1C3,SEPT9,NME2,TYMP,GPC3,CTSD,FAM117B,CXCL14,FAR2,TUBA1C,CDC42EP1,ADAMTS5,PFKFB3,FSTL3,KCNK2,TMC5,PGAP3,FYB,KLF4,FOSB,BCL2L1,ADAM12,DUSP1,RBX1,LIMA1,LSM1,IGFBP3,UHRF1BP1L,MEGF8,CBX3,POLE3,SULF1,PLGRKT,MECR,PCDHGB4,PKHD1L1,REXO2,HLA-G,SHC1,F8,MCAM,LOC102724428/SIK1,RHOBTB2,IGSF8,RPS3,DNAAF1,LONP1,WDR1,MT-CO1,PATL1,TP63,AKR1C1/AKR1C2,NPY1R,TUBG1,NQO1,HPS1,SOD1,NFE2L1,FGF1,CLGN,NOP16,MUC17,SLC25A5,CHI3L1,TUBA1B,THEMIS2,CPAMD8,CTGF,APOB,LDB3,HRAS,GYG2,VWA5A,MKI67,CECR1,BCAT1,PRG4,MPV17L2,ABR,ABCC1,KLF8,WNT5B,GSTM3,TUBB2A,ZNF592,NR1H3,JUNB,KIAA0100,FARSA,NUGGC,CCND2,CD68,BSG,C19orf53,MS4A4A,RMND1,RTN4,ALDOA,ARHGAP35,CCT3,GLUL,MAP2K3,CDK2AP2,SFRP1,AIDA,TCF7,CYR61,SETBP1,MYEOV,GSTP1,ALK,SORL1,ADAM17,GSTM5,NID2,HLA-A,UBQLN1,NQO2,CDK16,XPOT,FKBP1A,CCAR2,PFKL,DCLK1,H2AFZ,TAX1BP3,CDH11,ENAH,FANCE,RPL35,NDUFB9,CES1,GBA,PHB,UST,IFRD2,MT-CYB,TOP2A,TRIM16,TUB,TPO,FKBP5,SLC30A1,GJB2,LIMCH1,LAMB4,PLOD3,COX4I1,PLAT,RPS24,RPS19,NAP1L4,DNAH12,LETM1,ADRM1,EGR1,ATXN2L,COPS3,EIF3G,FIS1,CALM1 (includes others),COL5A3,SREBF2,SREBF1,CYCS,DVL3,CBX4,PLAU,MAPRE3,GAB2,PFN1,CD4,CXCL12,UTP4,TUBB,METAP2,MTCH2,VDAC2,PAX5,GSPT1,CNDP2,SLC25A6,DPP3,COMT,EIF5,RPL19,ITGAV,SIAH2,C1QBP,RET,DSP,EIF2AK1,IGFBP6,SPP1,GSDMB,GCNT2,LAGE3,CDK6,PSMC4,MAGED2,MARS,PKN1,CD3G,PPP2R1A,MAPK10,PHF1,AKR1B1,AKR7A2,SFRP2,HIGD1A,ATF5,PRDX5,PDGFA,MMP14,PCDH19,PKM,RBBP8,SLC7A1,CFTR,HIF1A,FAS,SLC39A1,HMOX1,CSPG4,THBS1,FLNA,NDUFC2,ANXA1,ERBB4,F5,TGFB2,GSTM4,KIT,TCP1,ARHGEF2,MAPKAPK2,OGDH,ALPL,HMGCS1,PI4KB,NDUFAF3,SEMA3E,ADCY2,TAF6,TPST2,MAP3K1,RNF43,QSOX1,ZBTB7C,GUK1,CEBPB,CSF1R,THRSP,ENO1,MT-ND5,DIP2C,LPAR1,SLC16A1,CYC1,ASAP2,C6,ADAM9,PPP2R1B,SCAND1,MMP9,SHMT2	333	
Cardiovascular System Development and Function, Organismal Development	vasculogenesis	vasculogenesis	3.10E-10	 	1.653	bias	-1.025	ADAMTS8,REM1,CTGF,APOB,HRAS,COL8A1,C1QA,ODC1,SPRY4,POR,SGPL1,SRPX2,GNA13,MGAT1,YWHAG,CNR1,PTP4A3,FGFR2,ANXA2,JUNB,SMOC2,ROR1,BSG,YARS,CTSB,ALCAM,MAP2K3,LRP8,CYR61,C3AR1,APOE,DDIT3,GBP1,ADIPOQ,PPIA,PROX1,COL15A1,SMARCA4,LIPA,OGT,PRKCE,DAB2,STIM1,SARS,AMOT,PLOD3,PLAT,EGR1,CYP1B1,APP,GRN,WARS2,ITGB2,EDIL3,KIF7,CSF1,PPP1R16B,SERPINH1,NR4A1,PSAP,ARHGDIA,BMPER,PLAU,BMP6,NAB2,HOXB5,SOCS3,SEPT9,UNC5B,CXCL12,TYMP,SDC4,GPC3,CD63,METAP2,CD28,HS6ST1,RHOG,CXCL14,ITGAV,CYBB,STAB1,GCLM,GSK3B,GPC1,KLF2,FERMT3,PTX3,PFKFB3,SPP1,STK39,LAMA2,THRA,CITED1,TIE1,ADRA2A,CDC42,ALDH1A2,IGFBP3,MEGF8,TFPI,AKR1B1,TMOD1,CD151,SULF1,IGFBP4,TFEB,GEM,LEP,SFRP2,PDGFA,MMP14,PKM,HIF1A,FAS,TNFRSF12A,SOX17,HMOX1,SHC1,CSPG4,THBS1,FLNA,KCNMA1,EFNB1,SAA1,TGFB2,KIT,EGLN3,CYGB,SEMA3B,MAPKAPK2,RAD23B,SEMA3E,CALR,VCAM1,EDNRB,MGAT5,SOD1,PLXND1,CSF1R,EDF1,FGF1,SHB,WARS,CAPNS1,EPHB3,C6,ADAM9,MMP9	149	
Neurological Disease	degeneration	degeneration of nervous system	3.55E-10	Decreased	-3.993	bias	-1.013	PLP1,VAC14,SLC9A1,CERS2,CTSD,GLB1,LYNX1,KIF1A,CYBB,MTMR2,GSK3B,RET,CLCN3,UNG,STXBP1,PTPRQ,CNR1,CNP,ASNA1,SLC12A7,NR1H3,SLC4A7,FGFR2,THRA,ARSA,SH3GL1,BCL2L1,IL1RN,MAPT,CTSB,NAGLU,CLCN7,LRP8,SQSTM1,ESR2,SORL1,APOE,RAB1A,PYCARD,UBQLN1,ADIPOQ,HIF1A,MAFG,UCHL1,GBA,PARK7,STUB1,KCNMA1,TGFB2,TUB,NFE2L2,NDUFS4,PLAT,PRNP,EDNRB,TYROBP,SOD1,CSF1R,ZPR1,NFE2L1,APP,GRN,NTRK3,SLC33A1,PPT1,TPP1,PSAP,C6,NCAM1	69	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	fatty acid metabolism	4.19E-10	Increased	4.393	bias	0.836	APOB,HRAS,ABCC6,POR,SGPL1,LTF,CTSS,ABCC1,TXN,CNR1,MSMO1,NR1H3,ELOVL1,PLAA,HSPA8,AACS,RTN4,ME2,PLTP,ADCYAP1,FH,ESR2,HACD3,EPHX1,APOE,GDF15,ADIPOQ,CRAT,TECR,C1QTNF3,LIPA,CES1,GBA,TNXB,PLIN2,HPGDS,SMPD3,CD209,SLC25A13,TNFRSF1A,FCGR2A,EGR1,ALOX5AP,SLC25A1,TRIB3,CYP1B1,APP,MYO5A,CSF1,SREBF1,FCER1G,TSPO,PSAP,ABCC3,BMP6,NCAM1,SOCS3,PLP1,AKR1C3,CD4,CXCL12,PCCB,NPC1L1,SLC27A4,CERS2,PTGES2,HOXA10,NDUFS6,ITGAV,ACOT1,FAR2,MID1IP1,ABCB11,GPC1,MDH2,NSMAF,ACSL3,GLYAT,GM2A,ARSA,SMPD2,BCL2L1,CDC42,IL1RN,MAPK10,CD14,ACOT4,AKR1B1,CYP4A11,SCD,LEP,MSR1,MECR,PKM,UGCG,CFTR,CD83,ME1,FAS,IRAK1,TACR1,HMOX1,PARK7,ANXA1,SAA1,ERBB4,KIT,OGDH,PRNP,AKR1C1/AKR1C2,CYP27A1,EDNRB,NQO1,SNTB1,MAP3K1,SOD1,CEBPB,DEGS1,SLC16A1,SLC36A1,APOC1,SLC27A3	122	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	leiomyomatosis	leiomyomatosis	4.53E-10	 	 	 	 	RAP2B,NR6A1,SOCS3,TWF1,PLP1,MEGF9,RPE,AHCYL1,SCN7A,MAF,MRVI1,NR2F1,CXCL14,RPL19,ERAL1,WNT5B,SLC2A5,ALDH1B1,CALCRL,CAPN6,PLD3,SLC24A3,CNP,FGFR2,RAPGEF3,AP2S1,RPL9,KCNG1,ADAM12,ADRA2A,DUSP1,ALDOA,SFRP1,CYR61,FH,ESR2,FTH1,S100A11,UQCRH,PHLDA2,SCARA5,SLC7A1,UGCG,FAS,SHC1,HSP90AB1,ERBB4,KIT,MICALL1,RPS19,DLGAP4,EDNRB,DVL1,HYAL1,GABBR1,SLC5A3,CSF1R,STXBP6,CYP1B1,FOS,RPS15,PLCB4,SLC33A1,NR4A1,NR5A2,ADRA1A,CLUH	67	
Neurological Disease	neurological signs	neurological signs	4.69E-10	 	-1.256	 	-0.703	NPM1,CTGF,AHCYL1,CA12,HRAS,PCDH7,GHITM,GNB1,CTSS,HADHB,PNKD,SYPL1,TXN,ZBTB16,AHCY,PPP1R1B,CNR1,TPM3,JUNB,RASL12,RPH3A,NGRN,HSPA8,NR1D1,CD68,GAPDH,LRP8,SCN11A,EIF3K,SORL1,APOE,NME1,USP18,GBP1,DDIT3,HMGN1,LRP6,PPIA,KAZN,UCHL1,CETN2,GBA,MAL2,SCN3A,SERPINA1,MYL12A,PLOD2,TNFRSF1A,MLF2,ACTB,EGR1,PSMB6,ARL3,APP,MYO5A,FOS,PSME1,LAMP2,NTRK3,CSF1,PPT1,UQCR10,SEPHS1,ADCY1,FKBP4,NR4A1,TSPO,CYCS,SOX9,ID4,ADRA1A,PFN1,PFKFB1,SCN7A,ATP5L,MT1M,SDC4,DYNLT1,HSPA5,FAM173A,AK1,RHOG,STRN4,NDUFA8,GAS5,KCNK2,ATP6V1A,LMCD1,FOSB,BCL2L1,ADRA2A,MAPT,XRCC6,RARRES3,RPSA,ETV5,SRM,SCD,COX7B,LEP,SLC1A4,SRPX,PKM,UGCG,ALAS1,NDUFA2,HMOX1,HINT1,CCDC88A,PREPL,DKK3,KCNMA1,PPP1R2,MICALL1,CRYM,PRNP,PSAT1,ADCY2,SOD1,CEBPB,TSN,NDUFA13,P4HA1,KCTD13,CAPNS1,TNFAIP8L2,CYC1,UQCRC1,CHI3L1,ATP6V1B2	130	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of breast cancer cell lines	4.85E-10	Increased	3.065	 	0.790	EEF1A1,CTGF,PFN1,SEPT9,ARF1,RACK1,HRAS,NCSTN,HSPA5,BIN1,SLC9A1,ODC1,CD28,CTSD,CSE1L,TXN,GPC1,C1QBP,SPP1,FSTL3,HDAC2,GPS2,PPP1R1B,FGFR2,FLOT1,NR1H3,ANXA2,CITED1,HMGA1,KLF4,SMPD2,SEL1L,BCL2L1,PPP2R1A,CCND2,INPP4B,ADAM12,RBX1,BTG2,IGFBP3,RARRES3,MAP2K3,CYR61,TFPI,ESR2,UBE2I,CD151,NME1,ADAM17,LEP,OSGIN1,MMP14,PKM,GDF15,HSPB8,EEF1B2,ADIPOQ,HIF1A,H2AFZ,HNRNPK,CDH11,RAP1GDS1,ENAH,SHC1,RABL6,PCK2,CSPG4,ERBB4,PRKCE,RHOBTB2,DAB2,SEMA3B,AMOT,SMPD3,NDUFAF3,S100A1,TAF6,TP63,TNFRSF1A,TRIM28,NQO1,SOD1,SNCG,CEBPB,COPS3,DEGS1,FGF1,RBCK1,GRN,FOS,CISD1,CSF1,SLC16A1,WBP2,PLAU	95	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	inflammation	inflammation of joint	4.97E-10	Increased	3.079	 	2.530	CTGF,C9orf72,MMEL1,CTSG,C1QA,CLSTN2,MNAT1,EEF1G,PTPRC,DYNLL1,IP6K3,CCND3,LTF,CTSS,ABCC1,CHCHD2,TXN,AIF1,WNT5B,LCP1,CALCRL,TUBB2A,NR1H3,HSPA8,TMEM127,CD68,CNTNAP4,IL10RA,MS4A7,CTSB,ALDOA,TFRC,GLUL,CDK2AP2,TCF7,C3AR1,SCN11A,FTH1,SORL1,APOE,RALA,DDIT3,HLA-A,PRDX1,BAG6,NQO2,HSPB8,ADIPOQ,ST6GALNAC4,FKBP1A,GPC4,SDC3,CDH11,C1QTNF3,LYZ,TNXB,ARFGAP1,SCN3A,FKBP5,ALPK2,RPL31,MYL12A,PLAT,IL11RA,RPS24,SIGMAR1,TYROBP,TNFRSF1A,FCGR2A,TUBB4B,TRIM28,ALOX5AP,SPATS2L,GRN,FOS,ITGB2,FTL,RPS16,CSF1,FCER1G,NR4A1,TSPO,PLAU,ADRA1A,SOCS3,SLC7A11,ARF1,PRMT3,CD4,SCN7A,CXCL12,SDC4,HSPA5,NRSN2,PAX5,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,TUBA1C,RET,ADAMTS5,RPL32,SPP1,DNASE2,HDAC2,LMO4,ERH,CDK6,RAB10,PHB2,PPP1R11,TPSAB1/TPSB2,TIE1,FOSB,SEL1L,ADRA2A,DUSP1,IL1RN,SLC7A2,NAGLU,CAPN2,PPAT,RPSA,IGFBP4,LEP,SLC1A4,MSR1,PRDX5,PYCARD,MMP14,SLC7A1,CD83,FAS,NELFE,EVC,HLA-G,HMOX1,SLFN5,RPL18A,CCSER2,THBS1,ANXA1,EFNB1,SAA1,TGFB2,KIT,EGLN3,RPS3,MAPKAPK2,ALPL,PRNP,ADAMTS15,C14orf2,CALR,VCAM1,TP63,TUBG1,NQO1,HYAL1,VSIG4,F13A1,HSPD1,CEBPB,CSF1R,ATIC,FAU,CXCL16,ENO1,APLP2,DIP2C,C6,CHI3L1,HLTF,MAP4K4,MMP9	179	
Inflammatory Response	inflammatory response	inflammatory response	5.63E-10	Increased	3.892	 	1.432	MAF,CTSG,SLC9A1,PTPRC,LTF,ABR,CTSS,PXK,ABCC1,TXN,GNA13,AIF1,TMSB10/TMSB4X,ZBTB16,HNRNPA0,LCP1,CALCRL,NR1H3,FLOT1,ANXA2,NINJ1,PLAA,NR1D1,YARS,IL10RA,CTSB,MAP2K3,SFRP1,C3AR1,ABHD12,APOE,ADAM17,DDIT3,DAPK2,SLC1A5,HLA-A,ADIPOQ,LGALS9,PPIA,FKBP1A,G6PC3,C1QTNF3,LIPA,LYZ,PLIN2,PRKCE,SERPINA1,STIM1,HPGDS,NFE2L2,PLAT,RPS19,MECOM,TYROBP,TNFRSF1A,FCGR2A,EGR1,GNA12,ALOX5AP,APP,GRN,FOS,ITGB2,MT-ND1,CSF1,TREM2,PPT1,FCER1G,AOX1,PLAU,SOCS3,TRAF3,PLP1,PFN1,CD4,CXCL12,SDC4,CD63,CD28,CXCL14,ITGAV,NUPR1,CYBB,C1QBP,EIF2AK1,PTX3,SPP1,STK39,RAPGEF3,CAPG,KLF4,CMC2,TPSAB1/TPSB2,OSTM1,EFS,ADRA2A,CDC42,IL1RN,MAPT,SLC7A2,CD14,CLCN7,PIK3AP1,SIRPA,RPL13A,CD151,LITAF,TOLLIP,LEP,MSR1,PPIB,SCARA5,PRDX5,PYCARD,MMP14,CFTR,IRAK1,TNFRSF12A,TACR1,HLA-G,HMOX1,SHC1,CCDC88A,PARK7,CSPG4,THBS1,ANXA1,EFNB1,DUSP10,SAA1,TGFB2,KIT,MAPKAPK2,LIAS,PRNP,VCAM1,EDNRB,NPY1R,HYAL1,SOD1,HSPD1,CEBPB,NFKBIZ,CSF1R,NFE2L1,FGF1,CXCL16,TNFAIP8L2,SLC33A1,C6,CHI3L1,NCKAP1L,MMP9	153	
Cellular Movement	cellular infiltration	cellular infiltration of cells	6.12E-10	 	-0.225	 	-1.056	SOCS3,NPM1,PLCB2,CTGF,PLP1,CMA1,UNC5B,CTSG,CXCL12,HRAS,CD28,LTF,CYBB,ZBTB16,PTX3,SPP1,CNR1,KCNK2,CNP,NINJ1,EFS,IL1RN,DUSP1,CTSB,IGFBP3,CD14,SFRP1,PLTP,CYR61,AKR1B1,C3AR1,ESR2,RPL13A,APOE,ADAM17,LEP,MSR1,PDGFA,HLA-A,NQO2,MMP14,HYOU1,ADIPOQ,PPIA,CFTR,HIF1A,FAS,TACR1,HMOX1,CCDC88A,CES1,GBA,THBS1,ANXA1,MCAM,DUSP10,SAA1,EGLN3,SERPINA1,STIM1,MAPKAPK2,NFE2L2,GJB2,PLAT,IL11RA,SEMA3E,VCAM1,UCP2,TNFRSF1A,NQO1,HYAL1,TRPA1,ALOX5AP,HSPD1,NFKBIZ,CSF1R,APP,CXCL16,ITGB2,EDIL3,TNFAIP8L2,GLIS2,CSF1,SREBF1,FCER1G,NR4A1,C6,PLAU,MMP9	89	
Gene Expression, Protein Synthesis	translation	translation of mRNA	7.35E-10	Decreased	-2.747	bias	 	RPL24,RPS3A,RACK1,EIF2S1,MT-TN,FARSB,EIF4G2,PABPC4,EIF5,MT-TS1,RPL19,RPS5,RPS3,SARS,MT-TD,RPS24,EIF2AK1,CALR,PATL1,NANOS1,MT-TY,RPL17,RPL30,EIF2B3,MT-TC,DNAJC1,EIF4E2,RPS29,EPRS,APP,EIF3G,RPS4Y1,WARS,MRPL51,MRPS7,MRPL17,RPS27L,BTG2,GAPDH,RPL37,CPEB1,MT-RNR1,RPL41,RPL13A,RPL38,MT-TP,EIF3K	47	
Gene Expression	expression	expression of mRNA	8.56E-10	 	-1.796	 	-1.086	PFN1,RACK1,CD28,EIF4G2,PABPC4,EIF5,RPL19,EIF2AK1,NANOS1,MT-TC,EIF2B3,EIF4E2,PKN1,EPRS,MRPL17,BTG2,GAPDH,MAP2K3,RPL13A,RPL41,EIF3K,MT-TP,RPL24,RPS3A,DDIT3,HMGN1,LRP6,EIF2S1,MT-TN,MLH1,FARSB,MT-TS1,TUB,SARS,RPS3,RPS5,MT-TD,RPS24,PATL1,CALR,MT-TY,EGR1,MAP3K1,RPL17,RPL30,DNAJC1,RPS29,APP,EIF3G,FOS,RPS4Y1,MRPL51,WARS,MRPS7,RPS27L,RPL37,MT-RNR1,CPEB1,RPL38	59	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	smooth muscle tumor	smooth muscle tumor	8.92E-10	 	 	 	 	RAP2B,NR6A1,SOCS3,TWF1,PLP1,MEGF9,RPE,AHCYL1,SCN7A,MAF,MRVI1,NR2F1,CXCL14,RPL19,ERAL1,WNT5B,SLC2A5,ALDH1B1,CALCRL,CAPN6,SPP1,PLD3,SLC24A3,CNP,FGFR2,RAPGEF3,HMGA1,AP2S1,RPL9,KCNG1,ADAM12,ADRA2A,DUSP1,ALDOA,SFRP1,CYR61,FH,ESR2,FTH1,S100A11,UQCRH,PHLDA2,SCARA5,SLC7A1,UGCG,FAS,SHC1,HSP90AB1,ERBB4,TOP2A,KIT,MICALL1,RPS19,DLGAP4,EDNRB,DVL1,HYAL1,GABBR1,SLC5A3,CSF1R,STXBP6,CYP1B1,FOS,RPS15,PLCB4,SLC33A1,NR4A1,NR5A2,ADRA1A,CLUH	70	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	hereditary myopathy	hereditary myopathy	9.08E-10	 	-1.149	bias	 	SLC7A11,KCND3,SEPT9,RRM2B,LDB3,BAG3,GARS,TYMP,C1QB,HSPA5,NEXN,BIN1,GSS,SCO2,GYS1,CCND3,CXCL14,IFI30,MTMR2,DSP,HK1,PSMB5,CFL1,SGCG,TUBB2A,LAMA2,SURF1,MT-TC,FIG4,MARS,DES,SDCBP,TLN2,YARS,PSMA4,RMND1,NAGLU,NDUFA12,TMEM43,AARS,SQSTM1,TMOD1,FKBP14,CNBP,MT-TP,S100A11,LITAF,FHL1,CHCHD10,HLA-A,HSPB8,FKBP1A,HIF1A,SDC3,NDUFA2,TAX1BP3,HINT1,COL6A1,MT-CYB,DAB2,STIM1,HPGDS,NDUFS4,PRNP,MT-CO1,SIGMAR1,PLOD2,CALR,MT-ATP6,COL5A2,MT-TY,RAB7A,EMD,TRIM2,POMGNT1,FGF1,APP,RBCK1,MT-ND5,LAMP2,MT-ND1,YARS2,NDUFS8,FLNC,SERPINH1,SLC16A1,CYCS,SGCD,MPV17,ADRA1A	90	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of membrane lipid derivative	9.13E-10	Increased	4.241	bias	1.172	EEF1A1,SOCS3,PLCB2,PIGU,PMVK,APOB,ARF1,DPM1,VAC14,SH3GLB1,NPC1L1,CERS2,POR,SGPL1,IP6K3,GLB1,ABCC1,PCYT2,MTMR2,DPM3,NSMAF,CLN6,PTX3,PEX7,GM2A,NR1H3,DGKE,ST6GALNAC3,FIG4,ARSA,ELOVL1,SMPD2,GPAA1,PLAA,SERINC2,BCL2L1,CDC42,MAPK10,RARRES3,PLEK,B3GNT5,PLTP,ADCYAP1,CNBP,SCD,APOE,RALA,LEP,PDGFA,DPM2,ADIPOQ,UGCG,HEXA,CFTR,FAS,HMOX1,LIPA,ARF6,CES1,GBA,ANXA1,SAA1,KIT,SERPINA1,SMPD3,PI4KB,CYP27A1,FCGR2A,LPCAT4,SLC6A6,AGPAT1,CSF1R,SPTLC3,DEGS1,FGF1,APP,FOS,ITGB2,ENO1,APLP2,SREBF2,SREBF1,PPT1,FECH,PSAP	85	
Cellular Movement	cellular infiltration	cellular infiltration of blood cells	9.17E-10	 	-0.345	 	-1.217	SOCS3,NPM1,PLCB2,CTGF,PLP1,CMA1,UNC5B,CTSG,CXCL12,HRAS,CD28,LTF,CYBB,ZBTB16,PTX3,SPP1,CNR1,KCNK2,CNP,NINJ1,EFS,IL1RN,DUSP1,CTSB,IGFBP3,CD14,SFRP1,PLTP,CYR61,AKR1B1,C3AR1,ESR2,RPL13A,APOE,ADAM17,LEP,MSR1,HLA-A,NQO2,MMP14,HYOU1,ADIPOQ,PPIA,CFTR,HIF1A,FAS,TACR1,HMOX1,CES1,GBA,THBS1,ANXA1,MCAM,DUSP10,SAA1,EGLN3,SERPINA1,STIM1,MAPKAPK2,NFE2L2,GJB2,PLAT,IL11RA,SEMA3E,VCAM1,UCP2,TNFRSF1A,NQO1,HYAL1,TRPA1,ALOX5AP,HSPD1,NFKBIZ,CSF1R,APP,CXCL16,ITGB2,EDIL3,TNFAIP8L2,GLIS2,CSF1,SREBF1,FCER1G,NR4A1,C6,PLAU,MMP9	87	
Nucleic Acid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of nucleoside triphosphate	9.34E-10	Increased	2.103	bias	0.304	SOCS3,ATP5G1,ATP5H,ATP5D,CHCHD10,COX8A,PKM,NME2,ATP5L,HIF1A,FAS,NNMT,AK1,G0S2,UQCC2,ENTPD5,NDUFS6,ATP5J2,LONP1,SLC25A13,MT-ATP6,UCP2,LETM1,PPIF,USMG5,SURF1,SOD1,HSPD1,GUK1,CTPS1,OLA1,APP,HSPA8,MAPT,ALDOA,CYCS,SLC25A5,VDAC1,ADCYAP1	39	
Connective Tissue Disorders, Inflammatory Disease, Skeletal and Muscular Disorders	rheumatic disease	Rheumatic Disease	1.22E-09	Increased	2.790	 	2.432	CTSG,CLSTN2,C1QA,MNAT1,EEF1G,PTPRC,IP6K3,LTF,CCND3,AIF1,LCP1,FGFR2,TMEM127,HSPA8,CTSA,SCUBE1,CTSB,TFRC,SCN11A,FTH1,APOE,DDIT3,PRDX1,BAG6,ADIPOQ,HSPB8,TNXB,ARFGAP1,LY6E,ALPK2,NFE2L2,SIGMAR1,OAS1,FCGR2A,TUBB4B,TNFRSF1A,ALOX5AP,SPATS2L,GRN,FOS,RPS16,CSF1,NR4A1,ADRA1A,SOCS3,SCN7A,HSPA5,CD28,RPS13,CXCL14,TUBA1C,ADAMTS5,RPL32,HDAC2,PPP1R11,FOSB,BCL2L1,ADRA2A,DUSP1,SLC7A2,NAGLU,CAPN2,IRF8,PPAT,RPSA,IGFBP4,SLC1A4,MSR1,PYCARD,HLA-G,CCSER2,RPL18A,SAA1,RPS3,C14orf2,AGFG1,VCAM1,TP63,EDNRB,HPS1,NQO1,TUBG1,HSPD1,ATIC,SHB,CXCL16,APLP2,CHI3L1,MAP4K4,CTGF,C9orf72,MMEL1,C1QB,GSS,DYNLL1,CTSS,PXK,ABCC1,CHCHD2,TXN,WNT5B,CALCRL,TUBB2A,NR1H3,CD68,CNTNAP4,IL10RA,MS4A7,GLUL,ALDOA,CDK2AP2,TCF7,C3AR1,SORL1,ADAM17,RALA,HLA-A,NQO2,FKBP1A,ST6GALNAC4,GPC4,SDC3,ASNS,CDH11,C1QTNF3,LYZ,SCN3A,FKBP5,RPL31,RPS24,IL11RA,PLAT,MYL12A,IMPDH2,TYROBP,TRIM28,ITGB2,FTL,FCER1G,TSPO,PLAU,SLC7A11,ARF1,CD4,PRMT3,CXCL12,SDC4,PAX5,NRSN2,G0S2,CAMK2D,UQCC2,RPL19,RET,DNASE2,SPP1,LMO4,ERH,PHB2,RAB10,CDK6,TPSAB1/TPSB2,TIE1,SEL1L,IL1RN,FPR3,LEP,PRDX5,MMP14,SLC7A1,CD83,FAS,NELFE,EVC,HMOX1,SLFN5,DKK3,THBS1,EFNB1,ANXA1,HSPE1,TGFB2,EGLN3,KIT,MAPKAPK2,ALPL,PRNP,ADAMTS15,CALR,HYAL1,VSIG4,F13A1,CEBPB,CSF1R,FAU,ENO1,ITPA,DIP2C,C6,HLTF,MMP9	201	
Cell Morphology	morphology	morphology of cells	1.68E-09	 	 	 	 	NPM1,COL8A1,C1QA,ODC1,GPR55,PTPRC,IP6K3,CCND3,GLB1,SPTB,ATF4,GNA13,AIF1,MGAT1,LAMTOR4,MRPL24,LCP1,YWHAG,CNR1,SURF1,FGFR2,TPM3,ANXA2,DES,NDN,HAX1,TMEM127,PYGO2,CTSA,GPR65,CTSB,TFRC,ADCYAP1,ESR2,STEAP3,APOE,SLC4A2,PRDX1,GDF15,ADIPOQ,HEXA,SDK1,COL15A1,SMARCA4,SYNM,CETN2,OGT,SORBS1,TNXB,PLIN2,CSNK2B,AMOT,NFE2L2,S100A1,FKBP3,MECOM,TNFRSF1A,GNA12,SLC6A6,DGAT2,SNCG,CSTB,CPEB4,GRN,MYO5A,FOS,MARCKSL1,ATP6V1F,NTRK3,FLNC,CSF1,SERPINH1,PPT1,NR4A1,TPP1,PSAP,ARHGDIA,SOX9,ADRA1A,SOCS3,SEPT9,MBP,TYMP,BIN1,PNRC2,CERS2,CD28,CTSD,HSPA4,RHOG,CHMP2A,ENTPD5,CXCL14,HOXA10,NDUFS6,HOXA7,ABCB11,GCLM,FSTL3,HDAC2,PTPRQ,GM2A,LAMA2,MAPK8IP2,HNRNPAB,SLC12A7,RAPGEF3,THRA,ARSA,MLST8,KLF4,BCL2L1,DNAJC5,ADRA2A,ADAM12,DUSP1,TXN2,XRCC6,ALDH1A2,IGFBP3,NAGLU,CAPN2,PIK3AP1,IRF8,TNS1,TMEM176B,SIRPA,RPSA,ETV5,CD151,PEBP1,SULF1,PTGFR,ATP6V0C,IGFBP4,MSR1,SRPX,PPIB,PYCARD,FAT3,HLA-G,SHC1,STUB1,RAD23B,ATP13A2,VCAM1,CAPZB,TP63,EDNRB,TRIM55,NPY1R,TUBG1,DVL1,MGAT5,ST3GAL6,EMD,SOD1,HSPD1,KIF3B,PSME3,AIFM2,ZPR1,FGF1,SERPINE2,APLP2,WIPF3,KIF5B,CHI3L1,FHL5,PLIN1,CTGF,LDB3,ITGA8,RAN,HRAS,SH3GLB1,EIF6,PEG10,LGMN,ABR,GAA,ZBTB16,WNT5B,CFL1,NR1H3,CPA3,TSPAN33,JUNB,HMGA1,PCK1,SH3GL1,SERINC2,INPP4B,CCND2,CD68,RTN4,MAP2K3,LRP8,B3GNT5,SFRP1,C3AR1,PHLPP1,SLC4A4,SORL1,ADAM17,TCEA1,PSMB10,HLA-A,CDK16,DCLK1,H2AFZ,ATP6AP1,CDH11,LIPA,CES1,GBA,RHOD,PRKCE,STIM1,ACVR1C,PLOD3,NDUFS4,IL11RA,PPIF,TYROBP,IMPDH2,EGR1,CYP1B1,POMGNT1,APP,FIS1,ITGB2,LAMP2,SREBF2,LIMS1,SREBF1,BMF,ARAP1,FCER1G,PEA15,CBX4,NCAM1,NAB2,GAB2,PLP1,PFN1,ARF1,CD4,MAP1B,CXCL12,SDC4,TAF10,CHTOP,NR2F1,CAMK2D,CYBB,ANXA7,GSK3B,RET,CLCN3,KLF2,FERMT3,EIF2AK1,SPP1,FST,DNASE2,SGCG,LMO4,ACP2,CLTC,TALDO1,ERH,CDK6,SLC4A7,TIE1,CDC42,IL1RN,SH2B3,MAPT,RARRES3,CLCN7,LFNG,TMOD1,JTB,PAFAH1B2,GEM,LEP,EPB41L3,MMP14,UGCG,SLC7A1,CFTR,FAS,TACR1,CCDC88A,THBS1,FLNA,DKK3,KCNMA1,ANXA1,EFNB1,PHYH,ERBB4,TGFB2,EGLN3,ARHGEF2,CACNG8,SHANK2,MAPKAPK2,ALPL,CTDNEP1,PRNP,CALR,COL5A2,AP3D1,MAP3K1,HYAL1,GABBR1,NFASC,CEBPB,NFKBIZ,CSF1R,SLC5A3,PLCB4,TNFAIP8L2,ITPA,LPAR1,APOC1,EPHB3,NCKAP1L,ATP6V1B2,MMP9	332	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by leukocytes	1.85E-09	 	-0.436	 	-1.281	SOCS3,NPM1,PLCB2,CTGF,PLP1,CMA1,UNC5B,CTSG,CXCL12,HRAS,CD28,LTF,CYBB,ZBTB16,PTX3,SPP1,CNR1,KCNK2,CNP,NINJ1,EFS,IL1RN,DUSP1,CTSB,IGFBP3,CD14,SFRP1,PLTP,CYR61,C3AR1,ESR2,RPL13A,APOE,ADAM17,LEP,MSR1,HLA-A,NQO2,MMP14,HYOU1,ADIPOQ,PPIA,CFTR,HIF1A,FAS,TACR1,HMOX1,CES1,GBA,THBS1,ANXA1,MCAM,DUSP10,SAA1,EGLN3,SERPINA1,STIM1,MAPKAPK2,NFE2L2,GJB2,PLAT,IL11RA,SEMA3E,VCAM1,UCP2,TNFRSF1A,NQO1,HYAL1,TRPA1,ALOX5AP,HSPD1,NFKBIZ,CSF1R,APP,CXCL16,ITGB2,EDIL3,TNFAIP8L2,GLIS2,CSF1,SREBF1,FCER1G,NR4A1,PLAU,C6,MMP9	86	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	advanced malignant solid tumor	2.04E-09	 	0.639	 	0.112	CTGF,HRAS,GYG2,RPS11,POR,PTPRC,CSE1L,KLF8,TMSB10/TMSB4X,MFAP5,GSTM3,TUBB2A,FGFR2,HAX1,ISLR,CCND2,GLUL,DUSP4,LRP8,SFRP1,ESR2,GSTP1,STEAP3,ALK,S100A11,MSC,GSTM5,TCEA1,NID2,DUSP6,ARL4C,GDF15,PPIA,FKBP1A,COL15A1,HSP90AB1,TOP2A,DAB2,PRKCE,MYL12A,PLAT,PLOD2,MECOM,FCGR2A,TUBB4B,FTL,CSF1,EIF4A1,P2RY12,PLAU,ABCC3,NCAM1,EEF1A1,SLC7A11,AKR1C3,CXCL12,RNASE1,TUBB,NR2F1,HOXA10,IFI30,TUBA1C,RET,CLCN3,PTX3,FST,SPP1,TBC1D2B,FSTL3,KCNK2,CDK6,SLC12A7,CAPG,KLF4,BCL2L1,EFS,PPP2R1A,IL1RN,ALDH1A2,NUAK1,TFPI,TMEM176B,POLE3,ERAP2,IGFBP4,SCD,SRPX,EPB41L3,PDGFA,MMP14,HIF1A,FAS,HMOX1,FLNA,KCNMA1,THBS1,MCAM,ERBB4,TGFB2,LOC102724428/SIK1,KIT,RNH1,ALPL,PRNP,SEC61G,NDUFB4,VCAM1,AKR1C1/AKR1C2,TP63,TUBG1,SLC5A3,CSF1R,ATIC,FGF1,EMP1,C2orf88,CLGN,CLDN2,ADAM9,MMP9	120	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoskeleton	2.07E-09	Increased	3.331	bias	-0.646	ADAMTS8,REM1,PCLO,C1QA,SLC9A1,CLIP1,LTF,GLB1,DGKG,PRKY,KNSTRN,GNA13,TMSB10/TMSB4X,LCP1,CNR1,TPM3,FLOT1,FGFR2,DES,NDN,FSCN1,BTG2,GPR65,PRKACA,ATMIN,GAPDH,ADCYAP1,ACTG1,APOE,NME1,PLXNA3,GDF15,ADIPOQ,SDK1,SYNM,CETN2,ARF6,ACTR3,SORBS1,AMOT,S100A1,TNFRSF1A,FCGR2A,GNA12,PVR,RNF6,CPEB4,GRN,MYO5A,FOS,MYOC,NTRK3,CSF1,FLNC,ARHGDIA,SOX9,BMP6,EEF1A1,NCDN,SEPT9,EML4,MBP,NTMT1,BAG3,NNMT,RHOG,HOXA7,CDC42EP1,HDAC2,PTPRQ,MAPK8IP2,CNP,LAMA2,RAPGEF3,CAPG,ARSA,SMPD2,MLST8,TXNRD1,SLC3A2,ADAM12,ADRA2A,MATN2,CAPN2,SIRPA,UBE2I,SULF1,FLRT1,HNRNPK,PHLDB2,SHC1,TWF2,LOC102724428/SIK1,KLHL42,DNAAF1,RPS3,LASP1,WDR1,AGFG1,CAPZB,TUBG1,DVL1,NQO1,MGAT5,SOD1,KIF3B,ZPR1,FGF1,KCTD13,KIFC3,CAPNS1,KIF5B,TTL,TBC1D7,CTGF,ITGA8,SH3BGRL3,ARPC5,RAN,MARK1,HRAS,KPNA1,BBS1,DYNLL1,CTSS,ABR,ABCC1,KIF21A,AFAP1,TESK1,RIMS3,CAPN6,CFL1,ROR1,NINJ1,BSG,STIP1,RTN4,ALDOA,LRP8,CDK2AP2,SFRP1,CYR61,RALA,BTG3,CDK16,SDC3,DCLK1,ENAH,UCHL1,DCLK2,UST,RHOD,SRGAP1,ACAP2,SNX10,PRKCE,TUB,NPTXR,PLAT,IL11RA,PTPRK,ACTB,EGR1,ARL3,APP,TENM4,SREBF1,TREM2,ADCY1,ARAP1,FKBP4,ATXN10,P2RY12,GABARAP,PLAU,RUFY3,MAPRE3,NCAM1,PFN1,PTPN23,ARF1,MAP1B,UNC5B,CXCL12,SDC4,DYNLT1,TUBB,NR2F1,COMT,ITGAV,MID1IP1,NEO1,GSK3B,C1QBP,RET,KLF2,DSP,FERMT3,SPP1,RAB10,LMCD1,CDC42,MAPT,MAPK10,RARRES3,NUAK1,UHMK1,PLEK,STXBP5,ARL2,SPIRE1,LEP,GEM,RNF165,EPB41L3,PDGFA,VAPA,PKM,UGCG,FAS,TNFRSF12A,CCDC88A,DKK3,FLNA,THBS1,ANXA1,ERBB4,EFNB1,TGFB2,KIT,MICALL1,NSMF,ARHGEF2,SHANK2,MAPKAPK2,ACTN1,PI4KB,PRNP,SEMA3E,CALR,MAP3K1,F13A1,PLXND1,CSF1R,LPAR1,EPHB3,NCKAP1L,RTN3	249	
Cancer, Organismal Injury and Abnormalities	metastatic solid tumor	metastatic solid tumor	2.41E-09	 	0.639	 	0.137	CTGF,HRAS,GYG2,RPS11,POR,PTPRC,CSE1L,KLF8,TMSB10/TMSB4X,GSTM3,TUBB2A,FGFR2,HAX1,ISLR,CCND2,GLUL,DUSP4,SFRP1,ESR2,GSTP1,STEAP3,ALK,S100A11,MSC,TCEA1,NID2,DUSP6,GDF15,FKBP1A,PPIA,HSP90AB1,TOP2A,PRKCE,MYL12A,PLAT,PLOD2,FCGR2A,TUBB4B,FTL,CSF1,EIF4A1,P2RY12,PLAU,ABCC3,NCAM1,EEF1A1,SLC7A11,AKR1C3,CXCL12,RNASE1,TUBB,NR2F1,HOXA10,IFI30,TUBA1C,CLCN3,RET,PTX3,FST,SPP1,FSTL3,KCNK2,CDK6,SLC12A7,CAPG,BCL2L1,EFS,PPP2R1A,IL1RN,NUAK1,TFPI,POLE3,ERAP2,SCD,EPB41L3,SRPX,PDGFA,MMP14,HIF1A,FAS,HMOX1,FLNA,THBS1,ERBB4,TGFB2,LOC102724428/SIK1,RNH1,KIT,ALPL,PRNP,NDUFB4,VCAM1,SEC61G,AKR1C1/AKR1C2,TP63,TUBG1,SLC5A3,CSF1R,ATIC,FGF1,EMP1,CLGN,ADAM9,MMP9	104	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	lysosomal storage disease	lysosomal storage disease	2.56E-09	Decreased	-2.754	bias	 	APOE,PLP1,SGSH,HEXA,UGCG,LIPA,CTSD,GBA,GLB1,PHYH,ALDH3A2,CLN6,ATP13A2,NAGA,ACP2,GM2A,HYAL1,ARSA,CLN5,GRN,CTSA,DNAJC5,IL1RN,PPT1,TPP1,CD14,PSAP,NAGLU,CLCN7	29	
Cancer, Organismal Injury and Abnormalities	tumorigenesis	tumorigenesis of tissue	2.62E-09	 	-0.254	 	0.106	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,SYT17,DCAF12,RNPEPL1,SRPRA,ANXA2,RPH3A,PLAG1,MYL9,RCC2,CD300C,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,LY6E,ALPK2,AMOT,TMEM123,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,GCSH,DERL1,NR4A1,WBP2,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,HS6ST1,LHFPL2,STRN4,STC2,ANKDD1A,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,RBX1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,SUMO3,ZC3H7B,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,VAT1,RPS15,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,RAP2B,TUBA1B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,LRFN5,C9orf91,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,KLF8,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,HMGA1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,SDC3,MRPL30,H2AFZ,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CCDC68,CD53,CD209,NAP1L4,SLC25A13,RRP1B,SYNGR2,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,NIPSNAP3A,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,PSMF1,CLTC,RPL29,IRX6,ANKMY2,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,TARS,SLC39A3,GALNT13,ATP6V1A,TPSAB1/TPSB2,TMEM189,YIF1A,CYP4A11,AKR7A2,UTP11,FPR3,GEM,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,SZRD1,RPS21,CEBPB,SYNPO2,ANO2,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,RRM2B,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,RAB38,SPTB,PLEKHO2,STAM,MGAT1,GNG12,ALDOC,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,CD52,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,SQSTM1,CHD1L,DEAF1,ESR2,MRPL37,TRAPPC5,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,C9orf24,HN1,SEC23B,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,SIGMAR1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,TRAF3,NCDN,TPPP3,MEGF9,USP5,SLC41A3,TMEM8A,NTMT1,PPFIBP2,ACO2,BAG3,NME2,MRPL47,RNASE1,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,RPS13,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,GULP1,PFKFB3,FSTL3,RILPL1,RERG,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,PSMD3,ARSA,TRIM35,FOSB,SDCBP,DNAJC5,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,RPLP1,SLC1A4,SRPX,SCARA5,PYCARD,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,DNAJC4,FYTTD1,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,TBC1D7,CHI3L1,SPCS1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ZNF592,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,SERINC2,NUGGC,DHRS9,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,P2RY8,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,PSMB10,PAM16,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,SP2,TAX1BP3,MACC1,DCLK2,LIPA,IFRD2,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,ADCK2,PEA15,PRMT5,P2RY12,CYCS,RUFY3,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,RPL13,CYBB,IFI30,ACOT1,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,LMO4,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,RPL28,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,MAPK10,HSPA13,ACOT4,UHMK1,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,MMP14,EPSTI1,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,REM1,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,NHLH1,PLTP,ADCYAP1,FTH1,EPHX1,EIF3K,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,PTRH1,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,RPS16,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SLC25A43,SEPT9,PCDH18,RABEP1,DPM1,ZNF79,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,C2orf83,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,MIIP,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,PPAT,UBE2I,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,HSPB6,MT-CO1,PATL1,PREB,MT-ATP6,TP63,TRIM55,IPO4,TRIM2,TSN,KIF3B,APLP2,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,ARPC5,HOXA6,RAN,GHITM,GYG2,MKI67,EIF6,GSS,EXPH5,RPS11,BBS1,RAD23A,DUSP3,LGMN,AHSA1,MPV17L2,PLCXD1,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,C19orf53,RTN4,CCT3,ME2,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,SDCCAG3,CDH11,ENAH,NDUFB9,LYZ,CES1,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,MYL12A,PLXNA1,DDX3Y,NOL6,PTPRK,PPIF,LPCAT4,CSRNP2,TIAL1,PAICS,CASK,LRRC8D,SNTG2,PSME1,CLIC6,HIST1H1E,IMMT,SLC48A1,CCDC85B,GLIS2,SREBF1,BRINP2,RHBDD2,TREM2,USP22,APOL4,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,CD4,PRMT3,MYH15,UNC5B,MAP1B,TCEB2,CD63,METAP2,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,RPL19,POMP,ANXA7,GSK3B,GPC1,PHPT1,C1QBP,RET,MDH2,BCKDK,DSP,MRPS15,PCNXL2,C7orf50,MFSD3,HK1,SLC4A5,FERMT3,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,CD14,NUAK1,RARRES3,CLCN7,EIF5A,LFNG,TBC1D16,DNPEP,ARL2,CREBL2,SPIRE1,SRM,SFRP2,RAB1A,SH3RF3,CNRIP1,TOLLIP,KIAA1191,ATF5,ILF2,CD83,MRPS30,RRAGD,SLC39A1,ERBB4,HSPE1,OAZ1,MAPKAPK2,CACNG8,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,PHLDA3,MAP3K1,R3HDM1,RNF43,CLEC9A,OAF,VSIG4,GUK1,MRPS16,PLXND1,KIAA1683,PLBD2,C2orf88,TMEM2,CYC1,ASAP2,EPHB3,NUCB2,GBE1,C6,UQCRC1,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,TMSB10/TMSB4X,UNG,LCP1,UXS1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,BTG2,PSMA5,PRELP,GPR65,ATMIN,SLC35B4,TMEM33,RPL41,SCN11A,STEAP3,PPDPF,CHCHD10,PHLDA2,OSGIN1,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,LURAP1L,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,MT-TY,TNFRSF1A,ZNF362,TRIB3,HSPA2,SPTLC3,GRN,GIN1,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,CCT7,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,LACTB,BCAS2,C20orf27,YWHAB,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,PIK3AP1,MRPS2,IRF8,MEGF8,SIRPA,RPSA,DOK5,ATP6V0C,UBXN1,SF3B5,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,REXO2,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,NPY1R,ZNF358,TUBG1,HPS1,NQO1,PWWP2B,NDUFV3,EMD,TRPA1,LARP6,NRBF2,FGF1,PDAP1,SHB,CIDEA,KIFC3,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,AHCYL1,C9orf72,SGSH,MMEL1,LDB3,TXNL4A,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CPA3,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,STIP1,LMOD2,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,RPL35,SEC61A1,ACSM5,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,ADRM1,LETM1,DTX4,TYROBP,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,FCER1G,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,MTCH2,VDAC2,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,EIF2AK1,IGFBP6,C6orf132,DNASE2,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,PKM,VAPA,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,ERV3-1,TNFRSF12A,EVC,TACR1,SOX17,SEPHS2,HMOX1,CCDC88A,NLK,PARK7,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,SEMA3B,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,COX17,CYP27A1,VANGL1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,SLC27A3,USP9Y,RTN3,SCAND1	1472	
Cardiovascular Disease, Organismal Injury and Abnormalities, Tissue Morphology	size	size of infarct	2.66E-09	 	-0.673	 	-0.133	APOE,LEP,SESN2,HLA-A,UBQLN1,DUSP6,GDF15,ADIPOQ,CXCL12,PPIA,SH3GLB1,C1QA,HIF1A,PANX1,TNFRSF12A,HMOX1,ANXA1,ANXA5,PRKCE,SIAH2,TXN,GSK3B,HPGDS,MAPKAPK2,UNG,PLAT,PRNP,SRR,UCP2,FSTL3,PPIF,TNFRSF1A,HSPH1,CNR1,EGR1,SOD1,APP,GRN,TNFAIP8L2,IL1RN,CSF1,FCER1G,ADCYAP1,ESR2,MMP9	45	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis	2.97E-09	Decreased	-3.045	bias	-0.998	ABHD12,APOE,PLP1,ADIPOQ,SH3GLB1,CERS2,ABR,PRKCE,STAM,GSK3B,HPGDS,CLCN3,NFE2L2,ATP13A2,NDUFS4,PRNP,ACP2,PSMC4,NR1H3,SOD1,ARSA,CSF1R,HAX1,APP,GRN,OSTM1,DNAJC5,SLC33A1,CSF1,TREM2,PPT1,MAPT,CTSB,PSAP,CLCN7,SQSTM1,ESR2	37	
Cardiovascular System Development and Function, Organismal Development	angiogenesis	angiogenesis	3.00E-09	 	1.995	bias	-0.923	ADAMTS8,REM1,CTGF,APOB,HRAS,COL8A1,C1QA,ODC1,SPRY4,POR,SGPL1,GATAD2A,SRPX2,CTSS,GNA13,MGAT1,CALCRL,YWHAG,CNR1,PTP4A3,FGFR2,ANXA2,JUNB,SMOC2,ROR1,BSG,YARS,CTSB,RTN4,ADM2,ALCAM,MAP2K3,LRP8,CYR61,C3AR1,APOE,HTATIP2,DDIT3,GBP1,ADIPOQ,PPIA,PROX1,COL15A1,SMARCA4,OGT,LIPA,PRKCE,DAB2,STIM1,SARS,SMPD3,AMOT,NFE2L2,PLOD3,PLAT,TNFRSF1A,EGR1,CYP1B1,APP,GRN,WARS2,FOS,ITGB2,EDIL3,KIF7,CSF1,PPP1R16B,SERPINH1,NR4A1,PSAP,CYCS,ARHGDIA,BMPER,PLAU,BMP6,NAB2,HOXB5,SOCS3,GAB2,SEPT9,CMA1,UNC5B,CXCL12,TYMP,SDC4,GPC3,CD63,METAP2,CD28,HS6ST1,RHOG,CXCL14,CYBB,ITGAV,STAB1,GCLM,GSK3B,GPC1,KLF2,FERMT3,PTX3,PFKFB3,SPP1,STK39,LAMA2,RPL29,DGKE,RAPGEF3,THRA,CITED1,TIE1,ADRA2A,CDC42,IL1RN,ALDH1A2,IGFBP3,TFPI,MEGF8,AKR1B1,TMOD1,CYP4A11,RPSA,CD151,SULF1,IGFBP4,TFEB,GEM,LEP,SFRP2,PDGFA,MMP14,PKM,HIF1A,FAS,TNFRSF12A,SOX17,HMOX1,SHC1,CSPG4,THBS1,FLNA,KCNMA1,MCAM,EFNB1,SAA1,TGFB2,KIT,EGLN3,RNH1,CYGB,SEMA3B,MAPKAPK2,RAD23B,SEMA3E,CALR,VCAM1,EDNRB,MGAT5,HYAL1,SOD1,HSPD1,CSF1R,PLXND1,EDF1,FGF1,SHB,WARS,CAPNS1,EPHB3,C6,CHI3L1,ADAM9,MMP9	173	
Organismal Injury and Abnormalities, Tissue Morphology	size	size of lesion	3.14E-09	 	-1.013	 	-0.832	SOCS3,APOB,SESN2,CD4,CXCL12,SH3GLB1,C1QA,PANX1,NPC1L1,CTSS,SIAH2,TXN,GSK3B,UNG,PTX3,SPP1,FSTL3,CNR1,IL1RN,ADCYAP1,ESR2,APOE,LEP,MSR1,HLA-A,UBQLN1,DUSP6,GDF15,ADIPOQ,PPIA,HIF1A,TNFRSF12A,SHC1,HMOX1,CES1,ANXA1,ANXA5,F5,PRKCE,HPGDS,MAPKAPK2,NFE2L2,PRNP,IL11RA,PLAT,SRR,VCAM1,UCP2,PPIF,TNFRSF1A,HSPH1,EGR1,SOD1,APP,GRN,TNFAIP8L2,CSF1,FCER1G,NR4A1,MMP9	60	
Cell Death and Survival	cell death	neuronal cell death	3.37E-09	 	0.469	 	0.738	NPM1,CTGF,VAC14,HRAS,SH3GLB1,PANX1,SLC9A1,SGPL1,LGMN,KIF1A,ATF4,STAM,UNG,CNR1,SURF1,JUNB,HAX1,NR1D1,STIP1,BTG2,PRKACA,CTSB,GAPDH,MAP2K3,AARS,ADCYAP1,ESR2,ALK,APOE,GSTM5,DDIT3,UBQLN1,BAG6,DUSP6,GDF15,HYOU1,FKBP1A,UCHL1,HSP90AB1,GBA,PHB,UBE2K,NFE2L2,GJB2,PLAT,IL11RA,SIGMAR1,UCP2,PPIF,TNFRSF1A,EGR1,TRIB3,CPEB4,APP,FOS,NTRK3,LIMS1,CSF1,PPT1,PEA15,CYCS,PLAU,GAB2,PLP1,CD4,MBP,MAP1B,UNC5B,CXCL12,HSPA5,NR2F1,CTSD,LYNX1,PACS2,CYBB,GCLM,GSK3B,RET,BCKDK,SLC6A8,STXBP1,YWHAB,CDK6,RAPGEF3,CITED1,SMPD2,BCL2L1,DNAJC5,ADCYAP1R1,ADAM12,CDC42,DUSP1,IL1RN,MAPT,XRCC6,ALDH1A2,IGFBP3,MAPK10,NAGLU,CLCN7,LEP,PYCARD,VAPA,PCDHGB4,HIF1A,FAS,HMOX1,PARK7,KCNMA1,THBS1,EFNB1,TGFB2,TCP1,EGLN3,NSMF,CACNG8,RPS3,FAM162A,ATP13A2,PRNP,TP63,HSPH1,NQO1,MAP3K1,TRIM2,SOD1,HSPD1,CEBPB,PSME3,FGF1,SERPINE2,CAPNS1,MMP9	133	
Cellular Function and Maintenance	engulfment	engulfment of cells	3.93E-09	Increased	5.392	bias	1.553	NPM1,GAB2,RAB5C,PFN1,ARF1,CD4,MAP1B,RACK1,CXCL12,C1QA,GPC3,BIN1,CD63,CLIP1,SNX12,PTPRC,RHOG,ABR,ITGAV,CLCN3,ADAMTS5,KLF2,GULP1,PTX3,EIF2AK1,CLTC,FGFR2,NR1H3,FLOT1,RAPGEF3,CAPG,PGAP3,HAX1,AP2S1,HSPA8,CDC42,MS4A4A,ATP6V0D1,CD14,IRF8,SIRPA,ATP6V0C,APOE,RAB4A,RALA,LEP,MSR1,PYCARD,CUBN,HYOU1,FAT3,ADIPOQ,ATP6AP1,FAS,HMOX1,ARF6,THBS1,RHOD,MT-CYB,ARFGAP1,ANXA1,ANXA5,SAA1,TUB,PRKCE,DAB2,STIM1,MAPKAPK2,CALR,CD209,SRA1,UCP2,FCGR2A,RAB7A,STON1,RPS21,CEBPB,APP,ATP6V1E1,ITGB2,ATP6V1F,CSF1,TREM2,PPT1,FCER1G,ASAP2,PLAU,ATP6V1B2	88	
Lipid Metabolism, Small Molecule Biochemistry	storage	storage of lipid	4.24E-09	 	-0.264	 	-0.714	APOE,SCD,LEP,APOB,PLIN1,MSR1,EGR1,GM2A,SURF1,DGAT2,ADIPOQ,NR1H3,UGCG,HEXA,ARSA,OSTM1,CISD1,LIPA,CIDEA,SREBF2,PLIN2,ITGAV,OSBPL11,PLIN5,ACVR1C,SMPD3	26	
Cellular Assembly and Organization	formation	formation of cytoskeleton	4.59E-09	Increased	3.207	bias	0.833	NPM1,TWF1,CTGF,PFN1,ARF1,MAP1B,CXCL12,HRAS,SDC4,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,GSK3B,GNA13,AIF1,KLF2,TESK1,GNG12,CFL1,GNG2,CNP,CDK6,TPM3,RAPGEF3,JUNB,MLST8,HAX1,UBXN11,LMCD1,MYL9,ERP29,CDC42,MAPT,GPR65,C3AR1,SIRPA,ARL2,SLC4A2,LEP,PYCARD,SMARCA4,CDH11,PHLDB2,TACR1,ARF6,ACTR3,TWF2,SORBS1,THBS1,RHOD,FLNA,TUB,PRKCE,DAB2,ARHGEF2,GNG5,ASAP3,RPS3,AMOT,PLAT,VCAM1,CAPZB,TP63,FCGR2A,ACTB,GNA12,MAP3K1,SYNPO2,FGF1,APP,COL5A3,KCTD13,MYOC,LPAR1,ARAP1,FKBP4,PLAU,NCKAP1L	82	
Cellular Movement	cell movement	cell movement of tumor cell lines	4.92E-09	Increased	5.799	bias	2.151	CTGF,WHSC1,CTSG,HRAS,GNB1,DGCR6L,PTP4A2,SRPX2,CSE1L,KEAP1,ST6GALNAC2,AFAP1,GNA13,LCP1,PTP4A3,FGFR2,TPM3,ANXA2,HMGA1,ROR1,HAX1,NINJ1,BSG,FSCN1,CTSB,ALCAM,ARHGAP35,SQSTM1,CYR61,FH,ESR2,NME1,ADAM17,HTATIP2,RALA,ARPC1B,OSGIN1,GDF15,ADIPOQ,PPIA,RUVBL1,SDC3,ASNS,CDH11,ENAH,GRINA,SYNM,ARF6,PHB,PRKCE,DAB2,SERPINA1,STIM1,NFE2L2,PLAT,S100A1,PLXNA1,PTPRK,PPIF,EGR1,GNA12,IPO7,SNCG,PVR,APP,GRN,FOS,NTRK3,FLNC,CSF1,PRMT5,WBP2,SOX9,PLAU,BMP6,NCAM1,GAB2,SOCS3,PTPN23,VPS28,SEPT9,ARF1,USP5,RACK1,CXCL12,SDC4,MTCH2,CTBP1,CD28,RHOG,CXCL14,ITGAV,TUBA1C,GSK3B,C1QBP,RET,CLCN3,IGFBP6,SPP1,GSDMB,PHB2,RAPGEF3,KLF4,PKN1,LMCD1,FOSB,BCL2L1,SDCBP,ADAM12,CDC42,IGFBP3,CAPN2,TFPI,SIRPA,UBE2I,ETV5,CD151,PEBP1,SULF1,IGFBP4,LEP,F2RL3,PLGRKT,PDGFA,MMP14,PKM,HIF1A,HNRNPK,CLCN4,TACR1,HMOX1,SHC1,PSMD10,CCDC88A,STUB1,THBS1,DKK3,FLNA,ANXA1,MCAM,EFNB1,TGFB2,KIT,EGLN3,IGSF8,MAPKAPK2,LASP1,PRNP,NDUFAF3,CALR,VCAM1,TP63,BHLHE41,MAP3K1,MGAT5,CEBPB,CSF1R,FGF1,CAPNS1,LPAR1,SLC16A1,ADAM9,MAP4K4,MMP9	164	
Neurological Disease, Psychological Disorders	dementia	Dementia	5.40E-09	 	 	 	 	APOB,CTGF,C9orf72,RAN,NCSTN,ADGRL1,EEF1G,LGMN,CTSS,ATF4,TXN,UNG,PLD3,CNR1,PPTC7,HMGA1,CD68,MS4A4A,STIP1,PRKACA,CTSB,GAPDH,LRP8,PLTP,SQSTM1,FH,ESR2,SORL1,APOE,CHCHD10,DDIT3,UBQLN1,PRDX1,LRP6,UCHL1,LIPA,GBA,PRKCE,SERPINA1,NFE2L2,PLAT,TYROBP,FCGR2A,ACTB,SLC6A6,APP,GRN,FIS1,MT-ND1,NTRK3,SREBF2,SREBF1,LIMS1,TSPO,PSAP,PLAU,BMP6,ADRA1A,CLUH,GAB2,RACK1,CXCL12,TUBB,HSPA5,BIN1,CTSD,PACS2,GSK3B,IGFBP6,MACROD1,GM2A,CNP,HSPA9,GCNT2,HNRNPAB,MT-TC,EPRS,ADAM12,ADRA2A,MAPT,SLC7A2,IGFBP3,MAPK10,CD14,STXBP5,PHF1,DOK5,SCD,LEP,HIF1A,EIF2S1,MT-TN,HMOX1,PARK7,STUB1,BCYRN1,SENP3,IGSF8,PRNP,MT-CO1,SPG21,NQO1,SOD1,HSPD1,CSF1R,SERPINE2,CXCL16,TMEM2,MT-ND5,APLP2,APOC1,CHI3L1,RTN3,MMP9	114	
Carbohydrate Metabolism	synthesis	synthesis of carbohydrate	5.49E-09	Increased	3.124	bias	0.482	EEF1A1,SOCS3,GFPT1,PLCB2,GNPDA1,PLIN1,CTGF,PIGU,ARF1,DPM1,VAC14,HRAS,SH3GLB1,GNB1,PTPRC,HS6ST1,PGD,GYS1,CCND3,LTF,PCYT2,ITGAV,ATF4,CHST11,MTMR2,PGP,GOT1,GSK3B,GPC1,DPM3,SPP1,TKT,XYLT1,GNG2,GCNT2,RAB10,PCK1,GPAA1,SERINC2,NR1D1,ADCYAP1R1,BSG,CDC42,IL1RN,MPDU1,IGFBP3,GAPDH,PLEK,SFRP1,B3GAT3,ADCYAP1,AKR1B1,PTGFR,SCD,APOE,B3GALT6,RALA,LEP,PDGFA,HLA-A,PPP1R3C,DUSP6,DPM2,LRP6,HS2ST1,ADIPOQ,HEXA,FAS,ARF6,SORBS1,ANXA1,TGFB2,KIT,PI4KB,ADCY2,TNFRSF1A,FCGR2A,DGAT2,HYAL1,AGPAT1,CEBPB,CSF1R,ITGB2,NTRK3,CSF1,SREBF1,NR4A1,GBE1,PLAU,ADRA1A	90	
Cell Signaling, Small Molecule Biochemistry	synthesis	synthesis of nitric oxide	5.52E-09	 	0.161	 	-1.671	SOCS3,TRAF3,PFN1,ASS1,CTSG,CD28,HSPA4,DYNLL1,STC2,CPM,ABCC1,CYBB,GSK3B,AIF1,PTX3,SPP1,CNR1,CNP,JUNB,KLF4,TXNRD1,DUSP1,IL1RN,SLC7A2,IGFBP3,CD14,IRF8,ADCYAP1,TFPI,SIRPA,RPSA,APOE,LEP,HYOU1,ADIPOQ,SLC7A1,CFTR,CDH11,HLA-G,HMOX1,SHC1,PARK7,PRKCE,SMPD3,S100A1,CALR,SRR,UCP2,EDNRB,TNFRSF1A,NQO1,MAP3K1,SOD1,HSPD1,CEBPB,CYP1B1,APP,ITGB2,CALM1 (includes others),IMMT,CSF1,TSPO,PLAU	63	
Nucleic Acid Metabolism, Small Molecule Biochemistry	biosynthesis	biosynthesis of nucleoside triphosphate	5.81E-09	Increased	2.103	bias	0.268	SOCS3,ATP5G1,CHCHD10,ATP5D,PKM,COX8A,NME2,HIF1A,FAS,NNMT,AK1,G0S2,UQCC2,NDUFS6,LONP1,SLC25A13,MT-ATP6,UCP2,LETM1,PPIF,USMG5,SURF1,SOD1,HSPD1,CTPS1,APP,MAPT,ALDOA,CYCS,SLC25A5,VDAC1	31	
Cell Death and Survival	degradation	cellular degradation	6.74E-09	Decreased	-3.567	bias	-1.060	PLP1,SLC9A1,CERS2,CTSD,LYNX1,KIF1A,MTMR2,GSK3B,RET,CLCN3,UNG,STXBP1,PTPRQ,CNR1,CNP,SLC12A7,SLC4A7,NR1H3,FGFR2,THRA,ARSA,BCL2L1,IL1RN,MAPT,CTSB,NAGLU,LRP8,SQSTM1,ESR2,SORL1,APOE,RAB1A,UBQLN1,HIF1A,MAFG,UCHL1,LYZ,PARK7,STUB1,KCNMA1,TGFB2,TUB,NDUFS4,PRNP,PLAT,TP63,EDNRB,TYROBP,SOD1,CSF1R,ZPR1,APP,GRN,NTRK3,SLC33A1,PPT1,PSAP,TPP1,C6,NCAM1	60	
Energy Production, Nucleic Acid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of ATP	6.83E-09	Increased	2.103	bias	0.284	SOCS3,ATP5G1,CHCHD10,ATP5D,PKM,COX8A,HIF1A,FAS,NNMT,G0S2,UQCC2,NDUFS6,LONP1,MT-ATP6,SLC25A13,UCP2,LETM1,PPIF,USMG5,SURF1,SOD1,HSPD1,APP,MAPT,ALDOA,CYCS,SLC25A5,VDAC1	28	
Cell Death and Survival, Cellular Compromise, Neurological Disease, Tissue Morphology	degeneration	degeneration of neurons	7.06E-09	Decreased	-3.625	bias	-0.861	PLP1,SLC9A1,CERS2,CTSD,LYNX1,KIF1A,MTMR2,GSK3B,RET,CLCN3,UNG,STXBP1,PTPRQ,CNR1,CNP,SLC12A7,SLC4A7,NR1H3,FGFR2,THRA,ARSA,BCL2L1,IL1RN,MAPT,CTSB,NAGLU,LRP8,ESR2,SORL1,APOE,RAB1A,UBQLN1,HIF1A,MAFG,UCHL1,PARK7,STUB1,KCNMA1,TGFB2,TUB,NDUFS4,PRNP,PLAT,EDNRB,TYROBP,SOD1,CSF1R,ZPR1,APP,GRN,NTRK3,SLC33A1,PPT1,PSAP,TPP1,C6,NCAM1	57	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast or ovarian cancer	breast or ovarian cancer	8.01E-09	 	1.689	 	1.514	ADAMTS8,PCLO,VAC14,NPAS2,POR,CCND3,CSE1L,DGKG,AIF1,GNA13,SYT17,SRPRA,ALCAM,NHLH1,ACTG1,FTH1,EIF3K,EPHX1,HTATIP2,PRDX1,BAG6,COL15A1,SMARCA4,SYNM,RABL6,MECOM,TUBB4B,AFF3,KIF7,WBP2,NR4A1,SOX9,AKR1C3,SEPT9,SCN7A,AP1B1,GPC3,CTSD,CCT5,TUBA1C,ADAMTS5,HDAC2,FYB,TXNRD1,OLA1,BCL2L1,RBX1,LSM1,CBX3,SULF1,ZC3H7B,IGFBP4,PLGRKT,PCDHGB4,FAT3,PKHD1L1,MARVELD1,PHLDB2,HLA-G,F8,IGSF8,DNAAF1,LASP1,MT-CO1,PATL1,AKR1C1/AKR1C2,TP63,SOD1,SLC25A5,RAP2B,TUBA1B,THEMIS2,CPAMD8,CTGF,GYG2,MKI67,BBS1,PRG4,MPV17L2,MGAT4B,KLF8,CAPN6,JUNB,HMGA1,FARSA,SH3GL1,ACAD11,INPP4B,C19orf53,SNRNP25,NCLN,RMND1,RTN4,ARHGAP35,CCT3,SETBP1,GSTP1,SORL1,GSTM5,HLA-A,NQO2,FKBP1A,CCAR2,H2AFZ,CDH11,ENAH,NDUFB9,CES1,UST,PHB,MT-CYB,SCN3A,TRIM16,DIP2B,TUB,NPTXR,FKBP5,SLC30A1,LAMB4,LIMCH1,GJB2,RPS24,NAP1L4,PLXNA1,EGR1,COPS3,CALM1 (includes others),SREBF1,CLUH,NCAM1,PFN1,CD4,METAP2,FAM173A,GSPT1,CNDP2,SLC25A6,DPP3,COMT,RPL19,PGP,GSK3B,C1QBP,RET,DSP,PCNXL2,HK1,GSDMB,LAGE3,DGKE,MAGED2,CD3G,CYP4A11,AKR7A2,SFRP2,HIGD1A,ATF5,PCDH19,SSU72,SLC39A1,THBS1,ERBB4,HSPE1,SHANK2,OGDH,MAPKAPK2,TMEM104,TPST2,RNF43,MAP3K1,GUK1,CEBPB,SYNPO2,KIAA1683,THRSP,C2orf88,CYC1,ASAP2,EPHB3,C6,ADAM9,HLTF,PPP2R1B,WHSC1,IGSF6,COL8A1,KCMF1,CLIP1,ODC1,FADS3,IP6K3,EIF4G2,LTF,KEAP1,ATF4,MRPL24,ALDOC,UXS1,MFAP5,PPP1R1B,TPM3,FLOT1,FGFR2,NDN,HAX1,SPATA20,NRBP1,TMEM127,CTSA,SCUBE1,FSCN1,BTG2,GPR65,PSMA5,GAPDH,DUSP4,ESR2,SCN11A,STEAP3,APOE,NME1,FBXO10,CDH18,HN1,CUBN,ARL4C,GDF15,SEC23B,HSPB8,PROX1,ATRAID,MMP25,COL16A1,HSP90AB1,SORBS1,TNXB,PLIN2,ATP5J2,DAB2,SERPINA1,NFE2L2,TMC2,RPL4,MED20,FUCA2,GNA12,SLC39A6,ZNF362,TRIB3,C1orf122,HSPA2,CPEB4,FOS,MT-ND1,NTRK3,EIF4A1,ARHGDIA,ABCC3,NME2,TYMP,CES2,STARD7,NPC1L1,FAM117B,CXCL14,FAR2,STAB1,CDC42EP1,PFKFB3,FSTL3,TNPO1,GM2A,LAMA2,KCNK2,TMC5,SLC12A7,PGAP3,KLF4,DMXL2,FOSB,TLN2,ADAM12,DUSP1,ALDH1A2,LIMA1,IGFBP3,UHRF1BP1L,MEGF8,TMEM176B,POLE3,ERAP2,MSR1,MECR,LEO1,REXO2,MLH1,RAP1GDS1,SHC1,MCAM,LOC102724428/SIK1,RHOBTB2,RPS3,LONP1,WDR1,PSAT1,VCAM1,NPY1R,TUBG1,NQO1,HPS1,EMD,TRPA1,LARP6,ATIC,NFE2L1,FGF1,PDAP1,CXCL16,SHB,CLGN,NOP16,COX5A,MUC17,CHI3L1,APOB,LDB3,HRAS,VWA5A,KPNA1,CECR1,BCAT1,ABR,ABCC1,WNT5B,GSTM3,TUBB2A,FAM126B,ZNF592,AASS,NR1H3,KIAA0100,NUGGC,CCND2,BSG,CD68,MS4A4A,MS4A7,ALDOA,GLUL,MAP2K3,LRP8,CDK2AP2,SFRP1,AIDA,TCF7,CYR61,MYEOV,ALK,SLC4A4,ADAM17,LAPTM5,NID2,UBQLN1,CDK16,XPOT,PFKL,TTC1,DCLK1,TAX1BP3,FANCE,RPL35,GBA,IFRD2,TOP2A,TPO,PLOD3,COX4I1,PLAT,RPS19,DNAH12,LETM1,ADRM1,ATXN2L,EIF3G,FIS1,COL5A3,SREBF2,DOCK8,PEA15,CYCS,DVL3,CBX4,PLAU,MAPRE3,HOXB5,GAB2,CXCL12,XPO5,UTP4,TUBB,VDAC2,MTCH2,PAX5,EIF5,ITGAV,IFI30,SIAH2,RAD51C,EIF2AK1,IGFBP6,TBC1D2B,SPP1,ANLN,GCNT2,PSMC4,CDK6,MARS,PKN1,PPP2R1A,ADCYAP1R1,MAPK10,PHF1,AKR1B1,RNPEP,LEP,EPB41L3,PRDX5,PDGFA,MMP14,PKM,RBBP8,SLC7A1,CFTR,HIF1A,FAS,EVC,HMOX1,CCDC88A,SLFN5,PCK2,FLNA,NDUFC2,CSPG4,ANXA1,EFNB1,F5,TGFB2,GSTM4,KIT,TCP1,ARHGEF2,HMGCS1,STK40,ALPL,PI4KB,NDUFAF3,SEMA3E,ADCY2,TAF6,QSOX1,ZBTB7C,SLC5A3,CSF1R,ENO1,MT-ND5,ITPA,DIP2C,LPAR1,SLC16A1,RTN3,SCAND1,ATP6V1B2,MMP9,SHMT2	474	
Cellular Movement	invasion	invasion of tumor cell lines	9.93E-09	Increased	4.966	bias	1.875	WHSC1,CTGF,SLC9A1,PTP4A2,CTSS,CSE1L,KEAP1,TMSB10/TMSB4X,KLF8,WNT5B,LCP1,CNR1,PTP4A3,FGFR2,JUNB,HMGA1,ROR1,HAX1,BSG,FSCN1,CTSB,ALCAM,SFRP1,SQSTM1,CYR61,FH,ESR2,NME1,ADAM17,HTATIP2,RALA,GBP1,DUSP6,GDF15,ADIPOQ,RUVBL1,CDH11,ENAH,ARF6,PHB,RHOD,DAB2,PRKCE,SERPINA1,PLAT,PTPRK,PPIF,GNA12,EGR1,THAP11,IPO7,SNCG,CYP1B1,APP,GRN,ITGB2,NTRK3,WBP2,ARHGDIA,SOX9,PLAU,BMP6,ID4,GAB2,SEPT9,UNC5B,RACK1,CXCL12,NME2,SDC4,CBX5,CTBP1,CTSD,ENTPD5,ITGAV,GSK3B,SPP1,GSDMB,HDAC2,HNRNPAB,KLF4,SEL1L,BCL2L1,SDCBP,ADRA2A,ADAM12,CDC42,LIMA1,NUAK1,CAPN2,TFPI,RPSA,ETV5,CD151,PEBP1,SULF1,LEP,PDGFA,PLGRKT,MMP14,PKM,HIF1A,FAS,CLCN4,HMOX1,PSMD10,CCDC88A,CSPG4,DKK3,ANXA1,MCAM,SAA1,ERBB4,TGFB2,MAPKAPK2,PI4KB,LASP1,ADAMTS15,CALR,VCAM1,TP63,BHLHE41,VANGL1,MGAT5,CEBPB,SERPINE2,CAPNS1,LPAR1,ADAM9,MAP4K4,MMP9	131	
Cell Morphology, Cellular Function and Maintenance	autophagy	autophagy	1.08E-08	Increased	2.497	 	1.329	ICMT,C9orf72,VPS28,SESN2,CD4,BAG3,CXCL12,HRAS,SH3GLB1,HSPA5,CTSD,PLCE1,ATG9A,CHMP2A,GAA,MCOLN3,CYBB,NUPR1,ATF4,ANXA7,STAM,GSK3B,LMX1A,SPP1,HDAC2,ACP2,CLTC,RAPGEF3,ARSA,HSPA8,OSTM1,BCL2L1,CTSA,NR1D1,MAPT,DUSP4,SQSTM1,TBC1D16,PAFAH1B2,SCD,TFEB,LEP,RAB1A,DDIT3,SRPX,DAPK2,PYCARD,BAG6,PKM,HSPB8,ADIPOQ,FKBP1A,HIF1A,EIF2S1,FAS,HMOX1,SHC1,ARF6,GBA,STUB1,NACC1,SERPINA1,STIM1,NFE2L2,AMFR,ATP13A2,PRNP,UCP2,LETM1,NQO1,RAB7A,QSOX1,TRIB3,SOD1,CEBPB,SYNPO2,NRBF2,POLDIP2,APP,FIS1,CISD1,LAMP2,CAPNS1,SLC33A1,SERPINH1,BMF,COX5A,TBC1D7	88	
Cell Death and Survival	cell viability	cell viability of tumor cell lines	1.11E-08	Increased	5.410	bias	0.530	CTGF,WHSC1,RRM2B,HRAS,NCSTN,IP6K3,PTP4A2,ABCC1,MCOLN3,KIF1A,TXN,BIRC7,PPP1R1B,FGFR2,ELOVL1,HMGA1,NPY5R,ROR1,VKORC1,BTG2,PSMA4,SQSTM1,GSTP1,FTH1,PHLPP1,ALK,APOE,ADAM17,HTATIP2,ATP5H,DUSP6,GDF15,HSPB8,KAZN,ASNS,SMARCA4,SYNM,LYZ,HSP90AB1,PRKCE,NACC1,FKBP5,ALPK2,NFE2L2,PLAT,PTPRK,MECOM,TNFRSF1A,TRIM28,CASK,APP,NTRK3,SREBF2,PPP1R16B,EIF4A1,NR4A1,PSAP,PLAU,ABCC3,ID4,NCAM1,GAB2,SOCS3,PRPF19,PCDH18,PTPN23,SEPT9,RACK1,BAG3,CXCL12,TYMP,HSPA5,CTBP1,CAMK2D,PLCE1,DPP3,PACS2,NUPR1,CYBB,SNRPD1,POMP,GSK3B,GPC1,RET,BCKDK,SPP1,HDAC2,ANLN,PHB2,PSMC4,CDK6,PFDN5,AURKAIP1,PPP1R11,KLF4,SEL1L,BCL2L1,PPP2R1A,DUSP1,IL1RN,XRCC6,MAPT,IGFBP3,NUAK1,CAPN2,TFPI,PPAT,UBE2I,RPSA,SULF1,SCD,CARS,PYCARD,PKM,UGCG,SLC7A1,HIF1A,FAS,MLH1,IRAK1,CLCN4,HLA-G,HMOX1,HINT1,NLK,PARK7,FLNA,MED15,MCAM,DUSP10,ERBB4,KIT,TCP1,PSMA3,SELENOH,MAPKAPK2,ATP13A2,PRNP,TP63,USMG5,NPY1R,MAP3K1,SOD1,CEBPB,NDUFA13,THRSP,ENO1,KIFC3,PPP2R1B,RPL38	150	
Neurological Disease, Psychological Disorders	tauopathy	tauopathy	1.18E-08	 	1.787	 	1.381	CTGF,RAN,NCSTN,ADGRL1,EEF1G,LGMN,CTSS,ATF4,TXN,UNG,PLD3,CNR1,TUBB2A,PPTC7,HMGA1,CD68,MS4A4A,STIP1,PRKACA,CTSB,GAPDH,LRP8,PLTP,FH,ESR2,SCN11A,SORL1,APOE,DDIT3,UBQLN1,PRDX1,LRP6,UCHL1,LIPA,SCN3A,PRKCE,SERPINA1,NFE2L2,PLAT,FCGR2A,TUBB4B,TYROBP,ACTB,SLC6A6,APP,FIS1,MT-ND1,NTRK3,SREBF2,SREBF1,LIMS1,TSPO,PSAP,PLAU,BMP6,ADRA1A,CLUH,GAB2,RACK1,SCN7A,CXCL12,TUBB,HSPA5,BIN1,CTSD,PACS2,TUBA1C,GSK3B,IGFBP6,MACROD1,GM2A,CNP,HSPA9,GCNT2,HNRNPAB,EPRS,ADAM12,ADRA2A,MAPT,SLC7A2,IGFBP3,MAPK10,CD14,STXBP5,PHF1,DOK5,SCD,LEP,SLC1A4,HIF1A,EIF2S1,MT-TN,HMOX1,PARK7,STUB1,BCYRN1,SENP3,IGSF8,PRNP,MT-CO1,TUBG1,NQO1,SOD1,HSPD1,SERPINE2,CXCL16,TMEM2,APLP2,APOC1,CHI3L1,RTN3,MMP9	112	
Molecular Transport	export	export of molecule	1.21E-08	Increased	2.704	bias	0.234	PLCB2,APOB,AHCYL1,RAN,CXCL12,NME2,XPO5,HRAS,CHTOP,CTSS,CSE1L,ABCC1,ABCB11,SLC7A5,GSK3B,CLCN3,CNP,HSPA9,NR1H3,SLC38A3,BCL2L1,BSG,CDC42,MAPT,PRKACA,CD14,UHMK1,ATOX1,EIF5A,PLTP,ADCYAP1,XPO6,FTH1,APOE,SCD,LEP,MSR1,SLC1A5,GDF15,ADIPOQ,XPOT,CRAT,CFTR,FAS,IRAK1,HMOX1,CES1,FYTTD1,SAA1,BCAP31,CRYM,SLC30A1,CALR,AGFG1,LETM1,SNTB1,SLC25A1,APP,SREBF1,SLC16A1,APOC1,NR5A2,ABCC3,SLC47A1,NUTF2	65	
Cellular Growth and Proliferation, Tissue Development	proliferation	proliferation of connective tissue cells	1.23E-08	 	1.346	 	-0.943	NPM1,CTGF,HRAS,NCSTN,MKI67,SGPL1,LTF,CCND3,ATF4,TXN,AIF1,WNT5B,CNR1,DKC1,TPM3,FGFR2,ANXA2,JUNB,CCND2,CTSB,DUSP4,MAP2K3,SFRP1,CYR61,ESR2,GSTP1,FTH1,PHLPP1,ALK,S100A11,HMGN1,ADIPOQ,ATRAID,SP2,SMARCA4,OGT,NFE2L2,NDUFS4,PLAT,PTPRK,TNFRSF1A,ACTB,CASK,GRN,FOS,NTRK3,CSF1,SERPINH1,TREM2,PLAU,BMP6,NAB2,SOCS3,ICMT,TRAF3,SLC7A11,CXCL12,SDC4,HS6ST1,CTSD,PLCE1,HOXA10,NUPR1,ITGAV,IFI30,RET,IGFBP6,FST,SPP1,CLTC,CDK6,THRA,KLF4,SLC3A2,FOSB,BCL2L1,TLN2,CDC42,DUSP1,LIMA1,IGFBP3,GNL3,PPAT,SULF1,IGFBP4,LEP,GEM,PDGFA,MMP14,HIF1A,STXBP4,MLH1,FAS,TNFRSF12A,HMOX1,HINT1,PSMD10,DKK3,KCNMA1,SAA1,ERBB4,TGFB2,MAPKAPK2,TP63,EDNRB,MAP3K1,EMD,GABBR1,SOD1,CEBPB,PSME3,CSF1R,ATIC,FGF1,CAPNS1,LPAR1,MMP9	117	
Cardiovascular Disease	infarction	Infarction	1.26E-08	 	-0.253	 	0.270	APOB,SESN2,CXCL12,SH3GLB1,C1QA,NPC1L1,PANX1,NNMT,CYBB,ITGAV,TUBA1C,SIAH2,GCLM,TXN,GSK3B,UNG,PTX3,FSTL3,CNR1,TUBB2A,THRA,BCL2L1,ADRA2A,VKORC1,IL1RN,SH2B3,MAPT,CD14,LRP8,TFPI,ADCYAP1,ESR2,APOE,LEP,HLA-A,UBQLN1,DUSP6,GDF15,ADIPOQ,PPIA,HIF1A,TNFRSF12A,HMOX1,ANXA1,ANXA5,F5,PRKCE,STIM1,HPGDS,MAPKAPK2,PLAT,PRNP,SRR,UCP2,PPIF,TNFRSF1A,FCGR2A,TUBB4B,HSPH1,EGR1,TUBG1,F13A1,SOD1,CSF1R,APP,GRN,ITGB2,CAPNS1,TNFAIP8L2,CSF1,TREM2,FCER1G,CCT7,P2RY12,C6,MMP9,ADRA1A	77	
Cellular Function and Maintenance	endocytosis	endocytosis	1.40E-08	Increased	4.015	bias	0.968	RAB5C,C9orf72,ARF1,SCAMP2,MAP1B,RACK1,CXCL12,HRAS,GPC3,BIN1,CD63,SNX12,CYBB,STAB1,ADAMTS5,GULP1,EIF2AK1,CLTC,HSPA9,NR1H3,FLOT1,HAX1,AP2S1,HSPA8,OSTM1,CDC42,MS4A4A,ATP6V0D1,CD14,LRP8,SIRPA,SORL1,ATP6V0C,APOE,RAB4A,RAB1A,SCARA5,PYCARD,CUBN,HYOU1,FAT3,LDLRAD3,ATP6AP1,HNRNPK,HMOX1,ARF6,RHOD,ARFGAP1,ANXA5,SAA1,MICALL1,DAB2,STIM1,MAPKAPK2,PI4KB,CD209,TNFRSF1A,FCGR2A,RAB7A,STON1,CLEC9A,RPS21,SNCG,APP,GRN,ATP6V1E1,MYO5A,ITGB2,SCARA3,ATP6V1F,CSF1,PPT1,APOC1,ATP6V1B2,MMP9	75	
Tissue Morphology	quantity	quantity of cells	1.42E-08	Increased	3.667	 	-0.172	NPM1,PCLO,C1QA,SLC35C1,PANX1,GPR55,PTPRC,IP6K3,CCND3,GLB1,RAB38,ST6GALNAC2,SPTB,ATF4,STAM,GNA13,LMX1A,LAIR1,MFAP5,FGFR2,DES,HAX1,MYL9,CTSB,ALCAM,TFRC,SQSTM1,NHLH1,ADCYAP1,ESR2,DEAF1,STEAP3,FTH1,APOE,SLC4A2,DDIT3,PRDX1,GDF15,HSPB8,ADIPOQ,PPIA,SMARCA4,G6PC3,ARF6,SORBS1,SERPINA1,NFE2L2,S100A1,MECOM,TNFRSF1A,FCGR2A,GNA12,SLC6A6,SNCG,GRN,MYO5A,FOS,NTRK3,FLNC,CSF1,NR4A1,PSAP,ARHGDIA,SOX9,BMP6,SIM1,SOCS3,TRAF3,SEPT9,MBP,BAG3,STARD7,GPC3,CD28,CTSD,CXCL14,HOXA10,STAB1,PSMB5,HDAC2,FSTL3,LAMA2,RAPGEF3,THRA,FYB,SMPD2,KLF4,TXNRD1,FOSB,BCL2L1,ADAM12,DUSP1,XRCC6,ALDH1A2,IGFBP3,NAGLU,PIK3AP1,IRF8,SIRPA,CD151,LITAF,MSR1,PYCARD,PCDHGB4,EIF2S1,MLH1,IRAK1,HLA-G,SHC1,SAA1,SLC20A1,VCAM1,CAPZB,TP63,EDNRB,NPY1R,DVL1,NQO1,ST3GAL6,TRPA1,SOD1,HSPD1,PSME3,NFE2L1,FGF1,SERPINE2,CXCL16,CIDEA,APLP2,CAPNS1,SLC33A1,CHI3L1,FHL5,CTGF,APOB,MAF,HRAS,CHST2,ZBTB7B,SGPL1,DYNLL1,LGMN,CTSS,MGAT4B,ZBTB16,APEX2,WNT5B,CALCRL,DKC1,NR1H3,TSPAN33,PCK1,JUNB,HMGA1,SH3GL1,INPP4B,CCND2,BSG,IL10RA,B3GNT5,C3AR1,GSTP1,ALK,SLC4A4,ADAM17,RALA,RPS3A,PSMB10,HLA-A,NQO2,DUSP6,LRP6,CDK16,DCLK1,CDH11,LIPA,CES1,GBA,TUB,PRKCE,ACVR1C,SMPD3,PLAT,IL11RA,RPS19,TYROBP,IMPDH2,EGR1,TIAL1,POMGNT1,APP,B4GALT2,ITGB2,COL5A3,DOCK8,SREBF1,TREM2,BMF,FCER1G,P2RY12,PLAU,NCAM1,NAB2,GAB2,PLP1,CD4,MAP1B,CXCL12,CD63,CHTOP,NR2F1,PAX5,CAMK2D,PLCE1,COMT,CYBB,NEO1,GSK3B,RET,CLCN3,BCKDK,KLF2,DSP,FERMT3,EIF2AK1,IGFBP6,SPP1,FST,DNASE2,GCNT2,HSPA9,CDK6,SLC4A7,CDK2AP1,PKN1,OSTM1,CD3G,CDC42,IL1RN,SH2B3,MAPT,MAPK10,RARRES3,CLCN7,LFNG,CYP4A11,PAFAH1B2,LEP,PDGFA,MMP14,RBBP8,UGCG,SLC7A1,CFTR,CD83,HIF1A,FAS,HMOX1,HINT1,NLK,PARK7,CSPG4,THBS1,DKK3,FLNA,ANXA1,PHYH,DUSP10,ERBB4,EFNB1,TGFB2,KIT,HSD11B2,NSMF,HCST,MAPKAPK2,ALPL,CTDNEP1,PRNP,CALR,CYP27A1,RAB7A,VSIG4,F13A1,CEBPB,NFASC,IL20RB,CSF1R,ENO1,TNFAIP8L2,ITPA,LPAR1,PAG1,FASTK,C6,ADAM9,MMP9,CARM1	298	
Energy Production, Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry	concentration	concentration of ATP	1.52E-08	 	1.629	 	0.360	ATP5G1,PLCB2,CTGF,LEP,UBQLN1,MMP14,PKM,HIF1A,FAS,G6PC3,NFE2L2,S100A1,SLC25A13,MT-ATP6,UCP2,LETM1,GLRX2,NQO1,STOML2,APP,ENO1,BCL2L1,MICU1,SREBF2,SREBF1,SLC16A1,MAPT,IGFBP3,GAPDH,ALDOA,NUAK1,SQSTM1,VDAC1,ESR2	34	
Tissue Development	growth	growth of connective tissue	1.73E-08	 	1.032	 	-1.292	NPM1,CTGF,HRAS,NCSTN,MKI67,PTPRC,SGPL1,LTF,CCND3,ATF4,TXN,AIF1,WNT5B,CNR1,DKC1,TPM3,FGFR2,ANXA2,HMGA1,JUNB,CCND2,IL10RA,CTSB,DUSP4,MAP2K3,SFRP1,CYR61,ESR2,GSTP1,FTH1,PHLPP1,ALK,S100A11,HMGN1,ADIPOQ,ATRAID,SP2,SMARCA4,OGT,NFE2L2,NDUFS4,PLAT,PTPRK,MECOM,TYROBP,TNFRSF1A,ACTB,CASK,GRN,FOS,NTRK3,CSF1,SERPINH1,TREM2,PLAU,BMP6,NAB2,SOCS3,ICMT,TRAF3,SLC7A11,CXCL12,SDC4,CD28,HS6ST1,CTSD,PLCE1,HOXA10,NUPR1,ITGAV,IFI30,RET,IGFBP6,FST,SPP1,CLTC,CDK6,THRA,KLF4,SLC3A2,FOSB,BCL2L1,TLN2,CDC42,DUSP1,LIMA1,IGFBP3,GNL3,PPAT,SULF1,IGFBP4,LEP,GEM,PDGFA,MMP14,CD83,HIF1A,STXBP4,MLH1,FAS,TNFRSF12A,HMOX1,HINT1,PSMD10,DKK3,KCNMA1,SAA1,ERBB4,TGFB2,KIT,MAPKAPK2,TP63,EDNRB,MAP3K1,EMD,GABBR1,SOD1,CEBPB,PSME3,CSF1R,ATIC,FGF1,CAPNS1,LPAR1,MMP9	125	
Free Radical Scavenging, Molecular Transport	quantity	quantity of reactive oxygen species	1.83E-08	Decreased	-2.575	 	-2.092	APOE,LEP,APOB,PFN1,PRDX1,PRDX5,OSGIN1,UBQLN1,ADIPOQ,HRAS,FAS,CERS2,CD28,HMOX1,SHC1,HSPA4,PGD,PARK7,KEAP1,CYBB,CYGB,TXN,MAPKAPK2,KLF2,LONP1,NFE2L2,GMFB,PRNP,EIF2AK1,TP63,UCP2,TNFRSF1A,HSPA9,NQO1,SOD1,HMGA1,CSF1R,NFE2L1,APP,BCL2L1,CSF1,TXN2,ADAM9,FTH1	44	
Nucleic Acid Metabolism, Small Molecule Biochemistry	biosynthesis	biosynthesis of purine ribonucleotide	1.88E-08	Increased	2.103	bias	0.268	SOCS3,ATP5G1,CHCHD10,ATP5D,PKM,COX8A,HIF1A,FAS,NNMT,AK1,G0S2,UQCC2,NDUFS6,LONP1,MT-ATP6,SLC25A13,UCP2,LETM1,PPIF,USMG5,SURF1,SOD1,HSPD1,APP,MAPT,ALDOA,CYCS,SLC25A5,VDAC1	29	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease, Skeletal and Muscular Disorders	uterine leiomyoma	uterine leiomyoma	1.92E-08	 	 	 	 	RAP2B,NR6A1,SOCS3,TWF1,PLP1,MEGF9,RPE,AHCYL1,SCN7A,MAF,MRVI1,NR2F1,CXCL14,RPL19,ERAL1,WNT5B,SLC2A5,ALDH1B1,CAPN6,CALCRL,PLD3,SLC24A3,CNP,RAPGEF3,AP2S1,RPL9,KCNG1,ADAM12,ADRA2A,ALDOA,SFRP1,CYR61,ESR2,FTH1,UQCRH,PHLDA2,SCARA5,SLC7A1,UGCG,FAS,HSP90AB1,MICALL1,RPS19,DLGAP4,EDNRB,DVL1,HYAL1,GABBR1,SLC5A3,STXBP6,CYP1B1,FOS,RPS15,PLCB4,SLC33A1,NR4A1,NR5A2,ADRA1A,CLUH	59	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	cellular infiltration of phagocytes	2.43E-08	 	-1.117	 	-2.394	APOE,ADAM17,CTGF,PLP1,LEP,NQO2,UNC5B,ADIPOQ,CXCL12,PPIA,HRAS,CFTR,HIF1A,HMOX1,CES1,GBA,ANXA1,DUSP10,SAA1,CYBB,EGLN3,NFE2L2,IL11RA,SEMA3E,PTX3,SPP1,TNFRSF1A,CNR1,CNP,NQO1,NFKBIZ,CSF1R,NINJ1,APP,ITGB2,TNFAIP8L2,GLIS2,IL1RN,CSF1,SREBF1,C6,PLTP,PLAU,CYR61,RPL13A,MMP9	46	
Cellular Function and Maintenance	homeostasis	cellular homeostasis	2.49E-08	Increased	4.081	bias	1.011	CTSG,PANX1,SLC9A1,GNB1,PTPRC,ATG9A,MCOLN3,ATF4,STAM,GNA13,LMX1A,PPP1R1B,CNR1,ANXA2,CD52,HSPA8,CTSA,TFRC,DUSP4,ATOX1,SQSTM1,ADCYAP1,ESR2,APOE,USP18,SLC4A2,DDIT3,DAPK2,BAG6,ADIPOQ,HSPB8,LGALS9,PPIA,SMARCA4,G6PC3,ARF6,SORBS1,SERPINA1,BCAP31,AMOT,NFE2L2,TMEM123,SIGMAR1,OAS1,UCP2,MECOM,TNFRSF1A,FCGR2A,GNA12,SLC39A6,TRIB3,POLDIP2,FOS,SERPINH1,NR4A1,ABCC3,BMP6,SIM1,ADRA1A,ICMT,SOCS3,TRAF3,SEPT9,SESN2,MBP,BAG3,NME2,RNASE1,HSPA5,CD28,CTSD,HSPA4,AK1,STC2,CHMP2A,NUPR1,HOXA7,SESN3,HDAC2,STK39,MAPK8IP2,KCNK2,CNP,RAPGEF3,THRA,ARSA,KLF4,SLC3A2,BCL2L1,ADRA2A,XRCC6,IGFBP3,IRF8,CD151,SCD,IGFBP4,TFEB,MSR1,SRPX,PPIB,SCARA5,PYCARD,EIF2S1,HLA-G,SHC1,STUB1,MCAM,SAA1,LONP1,ATP13A2,RMDN3,TP63,EDNRB,NPY1R,NQO1,TRPA1,SOD1,HSPD1,NRBF2,FGF1,CISD1,CIDEA,APLP2,CAPNS1,KDM5D,SLC33A1,KIF5B,PSMD2,COX5A,MUC17,FECH,TBC1D7,THEMIS2,PLIN1,C9orf72,MAF,HRAS,SH3GLB1,NCSTN,ZBTB7B,GAA,ABCC1,ZBTB16,RIMS3,SLC24A3,STOML2,PCK1,JUNB,HMGA1,INPP4B,NR1D1,BSG,IL10RA,RTN4,ALDOA,ARHGAP35,SFRP1,TCF7,CYR61,C3AR1,PHLPP1,SLC4A4,SORL1,ADAM17,SLC24A2,HLA-A,PPP1R3C,LRP6,FKBP1A,MAFG,C1QTNF3,GBA,PHB,DCXR,PRKCE,STIM1,NACC1,SLC30A1,AMFR,IL11RA,LETM1,PPIF,TYROBP,EGR1,APP,ITGB2,FIS1,FTL,COL5A3,LAMP2,IMMT,BMF,FCER1G,CYCS,PLAU,PLCB2,PLP1,SLC31A1,VPS28,ARF1,CD4,CXCL12,PAX5,CAMK2D,SLC25A6,PLCE1,ITGAV,CYBB,NEO1,ANXA7,GSK3B,CLCN3,KLF2,SLC4A5,EIF2AK1,SPP1,DNASE2,ACP2,CLTC,PHB2,CDK6,SLC4A7,SLC39A3,PKN1,OSTM1,CD3G,IL1RN,MAPT,NUAK1,LFNG,EIF5A,TBC1D16,VDAC1,AKR1B1,CYP4A11,PAFAH1B2,FPR3,LEP,RAB1A,PKM,CFTR,CD83,HIF1A,FAS,TACR1,HMOX1,PARK7,SELT,KCNMA1,ANXA1,EFNB1,F5,KIT,HSD11B2,NR2F6,PRNP,CALR,AP3D1,RAB7A,QSOX1,CEBPB,SYNPO2,LPAR1,SLC16A1,PAG1,GBE1,NUCB2,CLDN2,NCKAP1L,ATP6V1B2,CARM1	271	
Neurological Disease, Psychological Disorders, Skeletal and Muscular Disorders	Parkinson's disease	Parkinson's disease	2.49E-08	 	 	 	 	TUBA1B,EEF1A1,ARL6IP5,MBP,MAP1B,RAN,SLC25A6,RPL13,LTF,CSE1L,COMT,ATF4,CHCHD2,TUBA1C,GSK3B,SPP1,GPS2,CNR1,CNP,FLOT1,ANXA2,ELOVL1,ADRA2A,MAPT,RTN4,GSTP1,RPL13A,MT-TP,FTH1,PEBP1,SUMO3,APOE,RPS3A,HIGD1A,NQO2,COPE,FARSB,UCHL1,GBA,PARK7,STUB1,RPL31,ATP13A2,PRNP,CAPZB,RPL17,TRIB3,DNAJC1,SOD1,SNCG,APP,ATP6V1E1,FTL,MT-ND1,MT-ND5,TSPO,ADRA1A	57	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders	Huntington's disease	Huntington's Disease	2.79E-08	 	 	 	 	NPM1,CTGF,AHCYL1,CA12,PCDH7,HRAS,GHITM,GNB1,CTSS,HADHB,SYPL1,TXN,ZBTB16,AHCY,PPP1R1B,CNR1,TPM3,JUNB,RPH3A,RASL12,NGRN,HSPA8,NR1D1,CD68,GAPDH,SCN11A,EIF3K,SORL1,APOE,NME1,GBP1,DDIT3,HMGN1,PPIA,KAZN,UCHL1,CETN2,MAL2,SCN3A,SERPINA1,MYL12A,PLOD2,MLF2,TNFRSF1A,EGR1,ACTB,PSMB6,ARL3,MYO5A,FOS,PSME1,LAMP2,UQCR10,SEPHS1,FKBP4,NR4A1,TSPO,CYCS,SOX9,ID4,ADRA1A,PFN1,PFKFB1,SCN7A,ATP5L,MT1M,SDC4,DYNLT1,HSPA5,FAM173A,AK1,RHOG,STRN4,NDUFA8,GAS5,KCNK2,ATP6V1A,LMCD1,BCL2L1,XRCC6,RARRES3,ETV5,RPSA,SRM,SCD,COX7B,LEP,SLC1A4,SRPX,PKM,UGCG,ALAS1,NDUFA2,HMOX1,HINT1,PREPL,DKK3,PPP1R2,MICALL1,CRYM,PSAT1,ADCY2,TSN,NDUFA13,P4HA1,KCTD13,CAPNS1,CYC1,CHI3L1,UQCRC1,ATP6V1B2	111	
Respiratory Disease	pulmonary disease	advanced pulmonary disease	2.97E-08	 	 	 	 	EEF1A1,PPIA,CFTR,RNASE1,FAS,RPS11,HSP90AB1,KCNMA1,ERBB4,IFI30,TOP2A,TUBA1C,RET,TMSB10/TMSB4X,CLCN3,MYL12A,NDUFB4,SEC61G,TUBB4B,TUBB2A,TUBG1,ATIC,FTL,EIF4A1,GSTP1,POLE3,ALK	27	
Cell Death and Survival	cell death	cell death of neuroblastoma cell lines	3.26E-08	 	-0.209	 	-0.042	PEBP1,APOE,LEP,DDIT3,MBP,UGCG,FKBP1A,HSPA5,FAS,CCT4,SHC1,PARK7,STUB1,UBE2K,CCT5,TCP1,OAZ1,PRKCE,TXN,GSK3B,GPC1,HCST,RET,ATP13A2,PRNP,SPP1,HSPA9,SOD1,HMGA1,NDN,APP,HSPA8,ENO1,BCL2L1,CDC42,MAPT,PPT1,IGFBP3,CCT7,GAPDH,CCT3,CYCS,CAPN2,MAP2K3,SQSTM1,NCAM1	46	
Protein Degradation, Protein Synthesis	stabilization	stabilization of protein	3.35E-08	 	 	 	 	CREBL2,NPM1,PFN1,PPIB,PYCARD,BAG6,DPM2,BAG3,SH3GLB1,CCAR2,STXBP4,HSPA5,CCT4,SOX17,NLK,PARK7,PHB,STUB1,FLNA,AAK1,IFI30,CCT5,TCP1,DPM3,GPR26,VPS11,CALR,STXBP1,DVL1,PHB2,HSPD1,PSMD8,HSPA8,SEL1L,CTSA,LAMP2,SREBF1,CCT7,GAPDH,CCT3,DVL3	41	
Cell Death and Survival	cell death	cell death of connective tissue cells	4.35E-08	 	1.092	 	0.574	HRAS,SH3GLB1,EIF6,SLC9A1,SGPL1,ABCC1,ATF4,TXN,GNA13,UNG,NR1H3,FGFR2,MBD4,RTN4,CTSB,DUSP4,MAP2K3,SFRP1,CYR61,GSTP1,FTH1,EPHX1,USP18,GSTM5,DDIT3,ADIPOQ,TOP2A,UBE2K,NFE2L2,TMEM123,MECOM,TNFRSF1A,ACTB,EGR1,LZTS2,CYP1B1,APP,GRN,LAMP2,CSF1,SERPINH1,USP22,BMF,FKBP4,NR4A1,TPP1,CYCS,RPL37,EEF1A1,TRAF3,VPS28,UNC5B,SDC4,HSPA5,CTBP1,CTSD,RHOG,ENTPD5,NUPR1,ITGAV,GSK3B,DPM3,KLF2,NSMAF,EIF2AK1,SPP1,GNG2,CDK6,SHOX,BCL2L1,ADAM12,CDC42,DUSP1,MAPT,XRCC6,IGFBP3,GNL3,CREBL2,SFRP2,LEP,ATF5,PYCARD,MMP14,HIF1A,EIF2S1,MLH1,FAS,HMOX1,HINT1,PARK7,STUB1,FLNA,SAA1,ERBB4,TGFB2,HSD11B2,OAZ1,GMFB,PI4KB,TRAF7,PRNP,TP63,MAP3K1,EMD,GABBR1,SOD1,CEBPB,HSPD1,CSF1R,NFE2L1,ENO1,CIDEA,CAPNS1,COX5A,PPP2R1B,MMP9	116	
Cellular Assembly and Organization, Tissue Development	fibrogenesis	fibrogenesis	4.39E-08	Increased	2.545	bias	0.020	NPM1,TWF1,CTGF,PFN1,ARF1,MBP,MAP1B,CXCL12,HRAS,SDC4,HSPA5,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,GSK3B,GNA13,AIF1,KLF2,TESK1,GNG12,CFL1,THSD4,GNG2,CNP,CDK6,TPM3,RAPGEF3,JUNB,DES,MLST8,HAX1,UBXN11,LMCD1,CDC42,MAPT,GPR65,CD14,C3AR1,SIRPA,ARL2,APOE,FHL1,LEP,PYCARD,PROX1,HIF1A,SMARCA4,CDH11,PHLDB2,RAP1GDS1,TACR1,ARF6,ACTR3,TWF2,SORBS1,RHOD,TUB,DAB2,PRKCE,ARHGEF2,GNG5,ASAP3,RPS3,AMOT,PLAT,VCAM1,CAPZB,TP63,TNFRSF1A,FCGR2A,GNA12,MAP3K1,FGF1,APP,KCTD13,MYOC,LPAR1,SERPINH1,ARAP1,FKBP4,NCKAP1L	85	
Cellular Movement	migration	migration of tumor cell lines	4.76E-08	Increased	5.704	bias	2.340	CTGF,WHSC1,HRAS,DGCR6L,PTP4A2,SRPX2,CSE1L,KEAP1,AFAP1,GNA13,PTP4A3,TPM3,FGFR2,ANXA2,ROR1,HAX1,NINJ1,BSG,FSCN1,CTSB,ALCAM,CYR61,FH,ESR2,NME1,ADAM17,HTATIP2,RALA,OSGIN1,GDF15,ADIPOQ,RUVBL1,SDC3,ASNS,CDH11,ENAH,GRINA,SYNM,ARF6,PHB,DAB2,SERPINA1,STIM1,NFE2L2,PLAT,PLXNA1,PTPRK,PPIF,GNA12,EGR1,IPO7,PVR,SNCG,APP,GRN,NTRK3,CSF1,FLNC,WBP2,PRMT5,SOX9,PLAU,BMP6,NCAM1,GAB2,SOCS3,VPS28,SEPT9,ARF1,USP5,RACK1,CXCL12,SDC4,CTBP1,RHOG,ITGAV,GSK3B,C1QBP,IGFBP6,SPP1,PHB2,RAPGEF3,KLF4,PKN1,LMCD1,BCL2L1,SDCBP,ADAM12,CDC42,IGFBP3,CAPN2,TFPI,SIRPA,UBE2I,ETV5,CD151,IGFBP4,LEP,F2RL3,PDGFA,PLGRKT,MMP14,PKM,HIF1A,HNRNPK,CLCN4,TACR1,HMOX1,SHC1,PSMD10,CCDC88A,STUB1,THBS1,FLNA,ANXA1,MCAM,EFNB1,KIT,EGLN3,IGSF8,MAPKAPK2,LASP1,PRNP,NDUFAF3,VCAM1,TP63,BHLHE41,MAP3K1,MGAT5,CEBPB,CSF1R,FGF1,CAPNS1,LPAR1,SLC16A1,ADAM9,MAP4K4,MMP9	138	
Neurological Disease	dyskinesia	dyskinesia	5.05E-08	 	-1.177	 	-0.954	NPM1,CTGF,AHCYL1,CA12,PCDH7,HRAS,GHITM,GNB1,CTSS,HADHB,PNKD,SYPL1,TXN,ZBTB16,AHCY,PPP1R1B,CNR1,TPM3,JUNB,RPH3A,RASL12,NGRN,HSPA8,NR1D1,CD68,GAPDH,SCN11A,EIF3K,SORL1,APOE,NME1,GBP1,DDIT3,HMGN1,PPIA,KAZN,UCHL1,CETN2,MAL2,SCN3A,SERPINA1,MYL12A,PLOD2,MLF2,TNFRSF1A,EGR1,ACTB,PSMB6,ARL3,MYO5A,FOS,PSME1,LAMP2,NTRK3,PPT1,UQCR10,SEPHS1,FKBP4,NR4A1,TSPO,CYCS,SOX9,ID4,ADRA1A,PFN1,PFKFB1,SCN7A,ATP5L,MT1M,SDC4,DYNLT1,HSPA5,FAM173A,AK1,RHOG,STRN4,NDUFA8,GAS5,KCNK2,ATP6V1A,LMCD1,FOSB,BCL2L1,ADRA2A,XRCC6,RARRES3,ETV5,RPSA,SRM,SCD,COX7B,LEP,SLC1A4,SRPX,PKM,UGCG,ALAS1,NDUFA2,HMOX1,HINT1,PREPL,DKK3,KCNMA1,PPP1R2,MICALL1,CRYM,PSAT1,ADCY2,TSN,NDUFA13,P4HA1,KCTD13,CAPNS1,CYC1,UQCRC1,CHI3L1,ATP6V1B2	117	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function	proliferation	proliferation of fibroblast cell lines	5.07E-08	 	1.069	 	-0.790	ICMT,NPM1,PRPF19,RACK1,CXCL12,HRAS,CES2,SDC4,EIF6,ODC1,CTSD,PLCE1,ATG9A,CXCL14,RET,KLF2,EIF2AK1,PFKFB3,CLTC,CDK6,FGFR2,TPM3,PFDN5,JUNB,HMGA1,PLAG1,SLC3A2,SH3GL1,BCL2L1,CDC42,XRCC6,STIP1,BTG2,PSMA4,MAPK10,IGFBP3,ALDOA,TFRC,MAP2K3,EBNA1BP2,AKR1B1,SIRPA,ALK,RALA,LEP,PDGFA,BTG3,MMP14,TTLL4,PKM,HSPB8,ADIPOQ,HMOX1,C1QTNF3,HINT1,STUB1,THBS1,ERBB4,KIT,PRKCE,CYGB,CSNK2B,MAPKAPK2,TAF6,PPIF,NPY1R,EGR1,GNA12,MAP3K1,LZTS2,ZBTB7C,CEBPB,TSN,CSF1R,ATIC,FGF1,GRN,FOS,LPAR1,NTRK3,CSF1,RNF187,SOX9,CBX4,PPIL1,ADRA1A	86	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of granulocytes	5.69E-08	 	1.591	bias	-0.857	SOCS3,PLCB2,CTGF,PLP1,CMA1,UNC5B,CTSG,CXCL12,CD28,LTF,CXCL14,CYBB,NEO1,TXN,C1QBP,TMSB10/TMSB4X,PTX3,SPP1,FLOT1,CAPG,TPSAB1/TPSB2,YARS,DUSP1,IL1RN,RTN4,IGFBP3,CTSB,CD14,SFRP1,PLTP,ADCYAP1,C3AR1,SIRPA,CD151,APOE,ADAM17,LEP,MSR1,DAPK2,NQO2,GDF15,ADIPOQ,LGALS9,PPIA,CFTR,HIF1A,FAS,TACR1,HMOX1,ANXA1,SAA1,TGFB2,SERPINA1,STIM1,MAPKAPK2,NFE2L2,GJB2,PLAT,RPS19,VCAM1,TNFRSF1A,FCGR2A,NQO1,MGAT5,HYAL1,ALOX5AP,APP,GRN,ITGB2,MT-ND1,EDIL3,TNFAIP8L2,CSF1,FCER1G,NR4A1,PLAU,NCKAP1L,MMP9	78	
Drug Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of glutathione	5.87E-08	 	-0.015	 	-0.716	LEP,DDIT3,GLRX2,TALDO1,PKM,FGFR2,SOD1,EIF2S1,NFE2L1,CERS2,APP,TXN2,KEAP1,ABCC1,SLC16A1,CXCL14,ATF4,STIM1,SELENOH,GCLM,TXN,NFE2L2,GMFB,UNG,FTH1	25	
Metabolic Disease	amyloidosis	amyloidosis	6.04E-08	 	-1.140	bias	-0.414	CTGF,RAN,NCSTN,ADGRL1,EEF1G,LGMN,CTSS,ATF4,TXN,UNG,PLD3,CNR1,PPTC7,HMGA1,CD68,MS4A4A,STIP1,PRKACA,CTSB,GAPDH,LRP8,PLTP,FH,ESR2,SORL1,APOE,DDIT3,UBQLN1,PRDX1,LRP6,UCHL1,LIPA,LYZ,PRKCE,SERPINA1,NFE2L2,PLAT,FCGR2A,TYROBP,ACTB,SLC6A6,APP,FIS1,MT-ND1,NTRK3,SREBF2,SREBF1,LIMS1,PSAP,TSPO,PLAU,BMP6,ADRA1A,CLUH,GAB2,RACK1,CXCL12,TUBB,HSPA5,BIN1,CTSD,PACS2,GSK3B,RET,IGFBP6,PSMB5,MACROD1,GM2A,CNP,HSPA9,GCNT2,HNRNPAB,EPRS,ADAM12,ADRA2A,MAPT,SLC7A2,IGFBP3,MAPK10,CD14,NAGLU,STXBP5,PHF1,DOK5,SCD,TFEB,LEP,HIF1A,EIF2S1,MT-TN,HMOX1,STUB1,BCYRN1,SAA1,SENP3,IGSF8,PRNP,MT-CO1,NQO1,SOD1,HSPD1,SERPINE2,CXCL16,TMEM2,APLP2,PSMD2,APOC1,CHI3L1,RTN3,MMP9	110	
Organismal Injury and Abnormalities	growth	growth of lesion	6.66E-08	Increased	3.430	 	1.731	NPM1,CTGF,COX8A,CA12,HRAS,MKI67,ODC1,PEG10,CCND3,CTSS,ABCC1,TXN,AHCY,LAIR1,CNR1,PTP4A3,FGFR2,ANXA2,HMGA1,HSPA8,SH3GL1,PYGO2,BSG,BTG2,CTSB,GAPDH,ALCAM,MAP2K3,SFRP1,SQSTM1,CYR61,ESR2,FTH1,PHLPP1,ALK,APOE,NME1,FHL1,RALA,DDIT3,BTG3,GDF15,HYOU1,ADIPOQ,PROX1,RUVBL1,TAX1BP3,UCHL1,OGT,ARF6,PHB,FBXW11,PRKCE,ACVR1C,PLAT,EGR1,SLC39A6,LZTS2,SNCG,GRN,FOS,CSF1,FCER1G,NR4A1,SOX9,PLAU,BMP6,EEF1A1,ICMT,SOCS3,SLC7A11,SEPT9,ARL6IP5,RACK1,CXCL12,DIRAS1,HSPA5,GPC3,HSPA4,PGD,SAE1,PLCE1,CDON,CXCL14,CYBB,HOXA7,SIAH2,GSK3B,GPC1,RET,PFKFB3,SPP1,FST,HDAC2,CDK6,TRIM35,SLC3A2,BCL2L1,ADCYAP1R1,DUSP1,IL1RN,IGFBP3,NUAK1,CAPN2,IRF8,AKR1B1,CD151,LITAF,LEP,SFRP2,MMP14,PKM,HIF1A,FAS,NELFE,RAP1GDS1,HLA-G,HMOX1,SHC1,CCDC88A,PARK7,THBS1,FLNA,ANXA1,MCAM,TGFB2,KIT,RHOBTB2,CYGB,SEMA3B,HCST,UBA5,NDUFAF3,CALR,COX17,TP63,HSPH1,HYAL1,HSPD1,CSF1R,NDUFA13,FGF1,CXCL16,CISD1,CAPNS1,TNFAIP8L2,SLC16A1,ADAM9,MMP9	149	
Cellular Compromise	degeneration	degeneration of cells	6.76E-08	Decreased	-4.010	bias	-0.739	PLP1,LDB3,HRAS,SLC9A1,CERS2,GNB1,CTSD,LYNX1,KIF1A,MTMR2,TXN,GSK3B,RET,CLCN3,UNG,STXBP1,SPP1,HDAC2,PTPRQ,CNR1,CNP,SLC12A7,SLC4A7,NR1H3,FGFR2,THRA,ARSA,OSTM1,BCL2L1,DNAJC5,IL1RN,MAPT,CTSB,NAGLU,LRP8,ESR2,TMOD1,SORL1,APOE,RAB1A,UBQLN1,ADIPOQ,HIF1A,COL15A1,FAS,MAFG,UCHL1,PARK7,STUB1,KCNMA1,TGFB2,TUB,NDUFS4,PLAT,PRNP,EDNRB,TYROBP,SLC6A6,SOD1,CSF1R,ZPR1,FGF1,APP,GRN,NTRK3,SLC33A1,PPT1,TPP1,PSAP,ARHGDIA,PLAU,C6,NCAM1	73	
Cellular Assembly and Organization, Tissue Development	formation	formation of filaments	7.38E-08	Increased	2.596	bias	0.019	NPM1,TWF1,CTGF,PFN1,ARF1,MBP,MAP1B,CXCL12,HRAS,SDC4,HSPA5,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,GSK3B,GNA13,AIF1,KLF2,TESK1,GNG12,CFL1,THSD4,GNG2,CNP,CDK6,TPM3,RAPGEF3,JUNB,DES,MLST8,HAX1,UBXN11,LMCD1,CDC42,MAPT,GPR65,C3AR1,SIRPA,ARL2,APOE,FHL1,LEP,PYCARD,PROX1,SMARCA4,CDH11,PHLDB2,RAP1GDS1,TACR1,ARF6,ACTR3,TWF2,SORBS1,RHOD,TUB,DAB2,PRKCE,ARHGEF2,GNG5,ASAP3,RPS3,AMOT,PLAT,VCAM1,CAPZB,TP63,FCGR2A,GNA12,MAP3K1,FGF1,APP,KCTD13,MYOC,LPAR1,SERPINH1,ARAP1,FKBP4,NCKAP1L	82	
Connective Tissue Development and Function, Tissue Morphology	quantity	quantity of connective tissue	7.44E-08	Increased	3.418	 	2.053	GFPT1,APOB,CTGF,PLIN1,MAF,HRAS,EIF6,GPR55,PTPRC,SGPL1,LGMN,CCND3,SPTB,ATF4,APEX2,TKT,CNR1,NR1H3,FGFR2,TSPAN33,PCK1,JUNB,INPP4B,CCND2,TFRC,SQSTM1,SFRP1,ADCYAP1,ESR2,C3AR1,STEAP3,SLC4A4,APOE,PRDX1,GDF15,ADIPOQ,SDC3,SMARCA4,CDH11,LIPA,CES1,PLIN2,PRKCE,NFE2L2,RPS19,UCP2,TYROBP,EGR1,DGAT2,FOS,COL5A3,SREBF1,DOCK8,CSF1,PLAU,SIM1,NAB2,GAB2,SOCS3,TRAF3,BAG3,HSPA5,PAX5,NR2F1,COMT,CXCL14,UBL5,KLF2,EIF2AK1,SPP1,DNASE2,HDAC2,FSTL3,CDK6,RAPGEF3,THRA,KLF4,FOSB,BCL2L1,ADAM12,ADRA2A,CDC42,DUSP1,IL1RN,SH2B3,IGFBP3,CD14,CLCN7,SCD,LEP,MSR1,MMP14,SLC7A1,UGCG,CD83,HMOX1,NLK,CSPG4,PHYH,HSD11B2,HCST,ALPL,RAD23B,SLC20A1,TRIM55,NPY1R,NQO1,F13A1,SOD1,CEBPB,NFE2L1,CIDEA,CAPNS1,LPAR1,MMP9	115	
Neurological Disease	leukoencephalopathy	leukoencephalopathy	7.50E-08	 	-1.067	 	-0.797	APOE,PLP1,RRM2B,TYMP,NDUFA2,CERS2,SCO2,PHYH,KIT,RET,NDUFS4,MT-ATP6,MT-TY,CYP27A1,SURF1,MT-TC,EIF2B3,ARSA,HSPD1,CSF1R,MT-ND1,MT-ND5,POLR3B,NDUFS8,MAPT,NDUFA12,PSAP,MPV17	28	
Metabolic Disease	mitochondrial disorder	mitochondrial disorder	8.45E-08	 	 	 	 	SFXN4,RRM2B,TYMP,NDUFA1,COA3,NDUFA2,MT-TN,SCO2,NDUFB9,PCK2,MT-CYB,NDUFS6,COX14,EARS2,NDUFS4,NDUFAF3,MT-CO1,MT-ATP6,MPC1,MT-TY,SURF1,MT-TC,MRPS16,MT-ND5,MT-ND1,YARS2,NDUFS8,NDUFA11,CYC1,RMND1,NDUFA12,UQCRQ,MPV17,MT-TP	34	
Cancer, Organismal Injury and Abnormalities	abdominal neoplasm	abdominal neoplasm	8.82E-08	 	1.335	 	2.026	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,LY6E,ALPK2,AMOT,TMEM123,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,GCSH,DERL1,NR4A1,WBP2,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,HS6ST1,LHFPL2,STRN4,STC2,ANKDD1A,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,SUMO3,ZC3H7B,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,RPS15,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,RPLP0,RAP2B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,KLF8,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,HMGA1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,MRPL30,SDC3,ATP6AP1,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CCDC68,CD53,CD209,NAP1L4,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,GOT1,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,PSMF1,CLTC,RPL29,IRX6,ANKMY2,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,TARS,SLC39A3,GALNT13,TPSAB1/TPSB2,YIF1A,CYP4A11,AKR7A2,UTP11,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,HYAL1,SZRD1,CEBPB,SYNPO2,ANO2,EMP1,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,SPTB,PLEKHO2,STAM,MGAT1,GNG12,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,CD52,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,SQSTM1,CHD1L,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,HN1,SEC23B,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,SIGMAR1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,NCDN,TPPP3,MEGF9,USP5,TMEM8A,SLC41A3,NTMT1,PPFIBP2,ACO2,BAG3,NME2,MRPL47,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,GULP1,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,SDHC,THRA,CMSS1,PSMD3,ARSA,TRIM35,FOSB,DNAJC5,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,DNAJC4,FYTTD1,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,KDM5D,HMBOX1,SLC33A1,PSMD2,TBC1D7,CHI3L1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ZNF592,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,UQCRH,CDK16,CTNNA1,ACSF2,PFKL,SP2,MACC1,DCLK2,LIPA,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,PEA15,PRMT5,P2RY12,RUFY3,MAPRE3,HOXB5,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,IFI30,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,MAPK10,HSPA13,ACOT4,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,MICALL1,HSD11B2,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,TWF1,REM1,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,PTRH1,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SEPT9,PCDH18,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,PPAT,UBE2I,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,CRYM,HSPB6,MT-CO1,PATL1,PREB,TP63,TRIM55,IPO4,DVL1,TRIM2,TSN,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,ARPC5,HOXA6,RAN,GHITM,GYG2,MKI67,EXPH5,BBS1,RAD23A,DUSP3,LGMN,AHSA1,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,AP2S1,NGRN,FARSA,INPP4B,FNDC1,RTN4,CCT3,ME2,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,CDH11,ENAH,LYZ,CES1,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,PPIF,LPCAT4,CSRNP2,TIAL1,PAICS,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,IMMT,SLC48A1,GLIS2,SREBF1,BRINP2,RHBDD2,TREM2,USP22,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,TCEB2,METAP2,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,RPL19,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,DHX32,MDH2,BCKDK,DSP,PCNXL2,C7orf50,MFSD3,HK1,SLC4A5,FERMT3,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,RARRES3,NUAK1,CD14,CLCN7,LFNG,TBC1D16,DNPEP,ARL2,SPIRE1,SRM,SH3RF3,CNRIP1,TOLLIP,RAB1A,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,MAPKAPK2,CACNG8,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,PHLDA3,MAP3K1,R3HDM1,RNF43,OAF,VSIG4,GUK1,MRPS16,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,RPS4Y1,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,TMSB10/TMSB4X,UNG,LCP1,UXS1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,TPM3,NPY5R,COX7A1,RASL12,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,BTG2,GPR65,ATMIN,GAPDH,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,PHLDA2,OSGIN1,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,XIST,HSPA2,SPTLC3,GIN1,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,BCAS2,C20orf27,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,PIK3AP1,MRPS2,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,REXO2,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,NPY1R,ZNF358,TUBG1,HPS1,NQO1,PWWP2B,NDUFV3,EMD,TRPA1,LARP6,NRBF2,FGF1,PDAP1,CXCL16,SHB,CIDEA,SCARA3,KIF5B,NOP16,SLC36A1,COX5A,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,AHCYL1,C9orf72,SGSH,MMEL1,LDB3,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,DGCR6L,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,NANOS1,CFL1,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CPA3,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,STIP1,LMOD2,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,ADRM1,LETM1,DTX4,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,GABARAP,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,MTCH2,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,KLF2,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,PKM,VAPA,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,EVC,TACR1,SOX17,SEPHS2,HMOX1,CCDC88A,NLK,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,CYP27A1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1411	
Endocrine System Disorders, Organismal Injury and Abnormalities	thyroid nodule	thyroid nodule	9.67E-08	 	 	 	 	CALR,MT-ND5,MT-ND1,HSP90AB1,PARK7,PRDX5,ANXA5,CTSB,TPO,GSTP1,APP	11	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	lung cancer	advanced stage lung cancer	9.77E-08	 	 	 	 	EEF1A1,PPIA,RNASE1,FAS,RPS11,HSP90AB1,KCNMA1,ERBB4,IFI30,TOP2A,TUBA1C,RET,TMSB10/TMSB4X,CLCN3,MYL12A,NDUFB4,SEC61G,TUBB4B,TUBB2A,TUBG1,ATIC,FTL,EIF4A1,GSTP1,POLE3,ALK	26	
Cancer, Organismal Injury and Abnormalities	neoplasia	neoplasia of epithelial tissue	1.05E-07	 	0.138	 	0.601	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,SYT17,DCAF12,RNPEPL1,SRPRA,ANXA2,RPH3A,PLAG1,MYL9,RCC2,CD300C,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,LY6E,ALPK2,AMOT,TMEM123,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,GCSH,DERL1,NR4A1,WBP2,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,HS6ST1,LHFPL2,STRN4,STC2,ANKDD1A,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,RBX1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,SUMO3,ZC3H7B,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,VAT1,RPS15,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,RAP2B,TUBA1B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,KLF8,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,HMGA1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,MRPL30,SDC3,H2AFZ,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CCDC68,CD53,CD209,NAP1L4,SLC25A13,RRP1B,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,CLTC,RPL29,IRX6,ANKMY2,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,TARS,SLC39A3,GALNT13,ATP6V1A,TPSAB1/TPSB2,TMEM189,YIF1A,CYP4A11,AKR7A2,UTP11,FPR3,GEM,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,SZRD1,RPS21,CEBPB,SYNPO2,ANO2,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,RAB38,SPTB,PLEKHO2,STAM,MGAT1,GNG12,ALDOC,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,SQSTM1,CHD1L,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,C9orf24,HN1,SEC23B,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,TRAF3,NCDN,TPPP3,MEGF9,USP5,SLC41A3,TMEM8A,NTMT1,PPFIBP2,ACO2,BAG3,NME2,MRPL47,RNASE1,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,GULP1,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,PSMD3,ARSA,TRIM35,FOSB,SDCBP,DNAJC5,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,PYCARD,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,DNAJC4,FYTTD1,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,TBC1D7,CHI3L1,SPCS1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ZNF592,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,SERINC2,NUGGC,DHRS9,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,P2RY8,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,PSMB10,PAM16,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,SP2,TAX1BP3,MACC1,DCLK2,LIPA,IFRD2,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,ADCK2,PEA15,PRMT5,P2RY12,RUFY3,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,IFI30,ACOT1,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,LMO4,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,MAPK10,HSPA13,ACOT4,UHMK1,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,MMP14,EPSTI1,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,REM1,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,NHLH1,PLTP,ADCYAP1,FTH1,EPHX1,EIF3K,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,PTRH1,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,RPS16,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SEPT9,PCDH18,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,C2orf83,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,MIIP,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,UBE2I,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,HSPB6,MT-CO1,PATL1,PREB,TP63,TRIM55,IPO4,TRIM2,TSN,KIF3B,APLP2,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,ARPC5,HOXA6,RAN,GHITM,GYG2,MKI67,EIF6,GSS,EXPH5,RPS11,BBS1,RAD23A,DUSP3,LGMN,AHSA1,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,RTN4,CCT3,ME2,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,SDCCAG3,CDH11,ENAH,NDUFB9,LYZ,CES1,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,MYL12A,PLXNA1,DDX3Y,NOL6,PTPRK,PPIF,LPCAT4,CSRNP2,TIAL1,PAICS,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,IMMT,SLC48A1,CCDC85B,GLIS2,SREBF1,BRINP2,RHBDD2,TREM2,USP22,APOL4,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,CD4,PRMT3,MYH15,UNC5B,MAP1B,TCEB2,CD63,METAP2,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,RPL19,POMP,ANXA7,GSK3B,GPC1,PHPT1,C1QBP,RET,MDH2,BCKDK,DSP,MRPS15,PCNXL2,C7orf50,MFSD3,HK1,SLC4A5,FERMT3,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,CD14,NUAK1,RARRES3,CLCN7,EIF5A,LFNG,TBC1D16,DNPEP,ARL2,CREBL2,SPIRE1,SRM,SFRP2,RAB1A,SH3RF3,CNRIP1,TOLLIP,KIAA1191,ATF5,ILF2,CD83,MRPS30,RRAGD,SLC39A1,ERBB4,HSPE1,OAZ1,MAPKAPK2,CACNG8,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,PHLDA3,MAP3K1,R3HDM1,RNF43,OAF,VSIG4,GUK1,MRPS16,PLXND1,KIAA1683,PLBD2,C2orf88,TMEM2,CYC1,ASAP2,EPHB3,NUCB2,GBE1,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,TMSB10/TMSB4X,UNG,LCP1,UXS1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,BTG2,PSMA5,PRELP,GPR65,ATMIN,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,PHLDA2,OSGIN1,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,LURAP1L,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,HSPA2,SPTLC3,GRN,GIN1,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,CCT7,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,LACTB,BCAS2,C20orf27,YWHAB,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,PIK3AP1,MRPS2,IRF8,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SF3B5,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,REXO2,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,NPY1R,ZNF358,TUBG1,HPS1,NQO1,PWWP2B,NDUFV3,EMD,TRPA1,LARP6,NRBF2,FGF1,PDAP1,SHB,CIDEA,KIFC3,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,AHCYL1,C9orf72,SGSH,MMEL1,LDB3,TXNL4A,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CPA3,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,STIP1,LMOD2,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,RPL35,SEC61A1,ACSM5,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,ADRM1,LETM1,DTX4,TYROBP,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,MTCH2,VDAC2,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,EIF2AK1,IGFBP6,C6orf132,DNASE2,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,PKM,VAPA,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,TNFRSF12A,EVC,TACR1,SOX17,SEPHS2,HMOX1,CCDC88A,NLK,PARK7,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,COX17,CYP27A1,VANGL1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,SLC27A3,USP9Y,RTN3,SCAND1	1444	
Cardiovascular Disease	vaso-occlusion	vaso-occlusion	1.42E-07	 	-0.368	 	-1.247	SOCS3,PLIN1,SLC7A11,PFN1,APOB,ITGA8,CXCL12,MKI67,SDC4,NPC1L1,SLC9A1,GSS,NNMT,RHOG,CTSS,GAA,COMT,ITGAV,TUBA1C,GCLM,KLF2,PTX3,SPP1,SGCG,TKT,CNR1,TUBB2A,NR1H3,JUNB,RASL12,KLF4,FOSB,ADRA2A,VKORC1,MATN2,MAPT,RTN4,CD14,LRP8,PLTP,TFPI,ESR2,SCD,APOE,LEP,MSR1,MMP14,LRP6,GDF15,ADIPOQ,FKBP1A,HMOX1,SHC1,CES1,F8,SORBS1,THBS1,PLIN2,SAA1,F5,TGFB2,OGDH,NFE2L2,PLAT,SIGMAR1,VCAM1,COL5A2,CYP27A1,MECOM,TNFRSF1A,TUBB4B,IMPDH2,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,SOD1,HSPD1,APP,FOS,CXCL16,ITGB2,MTHFD1L,LAMP2,SUPV3L1,CSF1,APOC1,NR4A1,P2RY12,GBE1,PLAU,CHI3L1,SGCD,MMP9	96	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	lung cancer	stage 4 lung cancer	1.55E-07	 	 	 	 	EEF1A1,PPIA,RNASE1,FAS,RPS11,HSP90AB1,ERBB4,IFI30,TOP2A,TUBA1C,TMSB10/TMSB4X,RET,CLCN3,MYL12A,NDUFB4,SEC61G,TUBB4B,TUBB2A,TUBG1,CDK6,FGFR2,ATIC,FTL,EIF4A1,POLE3,ALK	26	
Post-Translational Modification, Protein Folding	folding	folding of protein	1.56E-07	 	1.969	 	1.633	DNAJA4,FKBP1A,SH3GLB1,PPIA,HSPA5,CCT4,HSP90AB1,STUB1,ENTPD5,TCP1,TXN,FKBP5,CALR,GLRX2,RAB7A,QSOX1,DNAJC1,HSPD1,TBCA,HSPA2,HSPA8,ERP29,PDIA6,FKBP4,AARS	25	
Cardiovascular Disease	occlusion	occlusion of artery	1.61E-07	 	-0.234	 	-1.129	SOCS3,PLIN1,SLC7A11,PFN1,APOB,ITGA8,CXCL12,MKI67,SDC4,NPC1L1,SLC9A1,GSS,NNMT,RHOG,CTSS,GAA,COMT,ITGAV,TUBA1C,GCLM,KLF2,PTX3,SPP1,SGCG,TKT,CNR1,TUBB2A,NR1H3,JUNB,RASL12,KLF4,FOSB,ADRA2A,VKORC1,MATN2,MAPT,RTN4,CD14,LRP8,PLTP,ESR2,SCD,APOE,LEP,MSR1,MMP14,LRP6,GDF15,ADIPOQ,FKBP1A,HMOX1,SHC1,CES1,F8,SORBS1,THBS1,PLIN2,SAA1,F5,TGFB2,OGDH,NFE2L2,PLAT,SIGMAR1,VCAM1,COL5A2,CYP27A1,MECOM,TNFRSF1A,TUBB4B,IMPDH2,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,SOD1,HSPD1,APP,FOS,CXCL16,ITGB2,MTHFD1L,LAMP2,SUPV3L1,CSF1,APOC1,NR4A1,P2RY12,GBE1,PLAU,CHI3L1,SGCD,MMP9	95	
Cellular Assembly and Organization	organization	organization of organelle	1.62E-07	Increased	2.104	bias	0.863	NPM1,ADAMTS8,RAB5C,ITGA8,SH3GLB1,PLEKHM2,GORASP2,RAB38,GAA,SPTB,AFAP1,CLN6,LCP1,CFL1,MFAP5,STOML2,ANXA2,CLN5,DES,TMEM127,ALDOA,GAPDH,CDK2AP2,CHCHD10,HMGN1,TMEM11,CTNNA1,HEXA,FKBP1A,ENAH,ARF6,SEC61A1,PHB,PEX10,TNXB,SNX10,PLOD3,RPS19,MFAP4,SNCG,CYP1B1,MYO5A,FIS1,SERPINH1,PPT1,DOPEY2,ARAP1,P2RY12,TPP1,PLAU,RUFY3,CLUH,SESN2,ARF1,MBP,SDC4,TUBB,CD28,CHMP2A,CHMP1A,RET,DSP,ACP2,PEX7,CNP,CLTC,PHB2,FIG4,ADAM12,CDC42,LIMA1,NAGLU,PLEK,TMOD1,SIRPA,ETV5,ARL2,TFEB,SFRP2,RAB1A,GEM,VPS4A,PARK7,FLNA,TGFB2,ARHGEF2,CTDNEP1,LONP1,ACTN1,PRNP,SEMA3E,AGFG1,COL5A2,CAPZB,CENPV,DVL1,HPS1,MGAT5,EMD,SOD1,NFASC,CSF1R,P4HA1,KIFC3,ITPA,SLC16A1	106	
DNA Replication, Recombination, and Repair	degradation	degradation of DNA	1.63E-07	 	0.797	 	0.402	APOE,NPM1,LEP,DDIT3,VPS28,MSR1,PPIB,UBQLN1,PAM16,CTSG,ADIPOQ,CXCL12,PPIA,HRAS,BIN1,FAS,REXO2,CD28,KEAP1,TOP2A,TGFB2,NACC1,SERPINA1,GSK3B,PRNP,CD53,BIRC7,DNASE2,CNR1,TIAL1,SOD1,TPSAB1/TPSB2,APP,GRN,ENO1,BCL2L1,BSG,DUSP1,CSF1,MAPT,PPT1,RTN4,CAPN2,ADCYAP1	44	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of lipid	1.69E-07	Increased	2.354	 	1.651	PLIN1,APOB,VAC14,HRAS,C1QA,KPNA1,POR,SGPL1,GLB1,CTSS,PLIN5,ZBTB16,CNR1,NR1H3,STOML2,FGFR2,PCK1,ELOVL1,HMGA1,NPY5R,B3GNT5,PLTP,ADCYAP1,ESR2,SLC4A4,ABHD12,APOE,PPP1R3C,HMGN1,ADIPOQ,G6PC3,GRINA,LIPA,ARF6,CES1,GBA,SORBS1,ANXA5,PLIN2,PRKCE,HPGDS,SMPD3,AMFR,PLAT,SIGMAR1,SLC25A13,UCP2,TNFRSF1A,EGR1,DGAT2,ALOX5AP,CYP1B1,APP,FOS,B4GALT2,EDIL3,SREBF2,CSF1,SREBF1,FCER1G,NR4A1,FKBP4,NR5A2,PSAP,ARHGDIA,ABCC3,EEF1A1,TRAF3,PLP1,PFKFB1,ARF1,CD4,MBP,BAG3,CXCL12,NPC1L1,SLC27A4,CERS2,CTSD,HS6ST1,COMT,ENTPD5,PCYT2,CXCL14,CYBB,ABCB11,NSMAF,SLC4A5,SPP1,STK39,DGKE,RAPGEF3,FIG4,THRA,SMPD2,SLC3A2,BCL2L1,ADRA2A,DUSP1,IL1RN,NAGLU,CD14,UHMK1,TFPI,AKR1B1,PTGFR,SCD,ANGPTL8,LEP,MSR1,PYCARD,UGCG,CFTR,HIF1A,FAS,TNFRSF12A,TACR1,HMOX1,HINT1,PCK2,CSPG4,DKK3,KCNMA1,PHYH,SAA1,LOC102724428/SIK1,HSD11B2,MAPKAPK2,CTDNEP1,PI4KB,PRNP,VCAM1,CYP27A1,NPY1R,NQO1,RAB7A,NXPH4,SOD1,CEBPB,NRBF2,ZPR1,THRSP,CIDEA,DGKQ,APOC1,NUCB2,MMP9	147	
Cancer, Organismal Injury and Abnormalities	growth	growth of tumor	1.69E-07	Increased	3.333	 	1.662	NPM1,CTGF,COX8A,CA12,HRAS,MKI67,ODC1,PEG10,CCND3,CTSS,ABCC1,TXN,AHCY,LAIR1,CNR1,PTP4A3,FGFR2,ANXA2,HMGA1,HSPA8,SH3GL1,PYGO2,BSG,BTG2,CTSB,GAPDH,ALCAM,MAP2K3,SFRP1,SQSTM1,CYR61,ESR2,FTH1,PHLPP1,ALK,NME1,FHL1,RALA,DDIT3,BTG3,GDF15,HYOU1,ADIPOQ,PROX1,RUVBL1,TAX1BP3,UCHL1,OGT,ARF6,PHB,FBXW11,PRKCE,ACVR1C,PLAT,EGR1,SLC39A6,LZTS2,SNCG,GRN,FOS,CSF1,FCER1G,NR4A1,SOX9,PLAU,BMP6,EEF1A1,ICMT,SOCS3,SLC7A11,SEPT9,ARL6IP5,RACK1,CXCL12,DIRAS1,HSPA5,GPC3,HSPA4,PGD,SAE1,PLCE1,CDON,CXCL14,CYBB,HOXA7,SIAH2,GSK3B,GPC1,RET,PFKFB3,SPP1,FST,HDAC2,CDK6,TRIM35,SLC3A2,BCL2L1,ADCYAP1R1,DUSP1,IL1RN,IGFBP3,NUAK1,CAPN2,IRF8,AKR1B1,CD151,LITAF,LEP,SFRP2,MMP14,PKM,HIF1A,FAS,NELFE,RAP1GDS1,HLA-G,HMOX1,SHC1,CCDC88A,PARK7,THBS1,FLNA,ANXA1,MCAM,TGFB2,KIT,RHOBTB2,CYGB,SEMA3B,HCST,UBA5,NDUFAF3,CALR,COX17,TP63,HSPH1,HYAL1,HSPD1,CSF1R,NDUFA13,FGF1,CXCL16,CISD1,TNFAIP8L2,SLC16A1,ADAM9,MMP9	147	
Cardiovascular Disease	occlusion	occlusion of blood vessel	1.78E-07	 	-0.163	 	-1.019	SOCS3,PLIN1,SLC7A11,PFN1,APOB,ITGA8,CXCL12,MKI67,SDC4,NPC1L1,SLC9A1,GSS,NNMT,RHOG,CTSS,GAA,COMT,ITGAV,TUBA1C,GCLM,KLF2,PTX3,SPP1,SGCG,TKT,CNR1,TUBB2A,NR1H3,JUNB,RASL12,KLF4,FOSB,ADRA2A,VKORC1,MATN2,MAPT,RTN4,CD14,LRP8,PLTP,TFPI,ESR2,SCD,APOE,LEP,MSR1,MMP14,LRP6,GDF15,ADIPOQ,FKBP1A,HMOX1,SHC1,CES1,F8,SORBS1,THBS1,PLIN2,SAA1,F5,TGFB2,OGDH,NFE2L2,PLAT,SIGMAR1,VCAM1,COL5A2,CYP27A1,MECOM,TNFRSF1A,TUBB4B,IMPDH2,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,SOD1,HSPD1,APP,FOS,CXCL16,ITGB2,MTHFD1L,LAMP2,SUPV3L1,CSF1,APOC1,NR4A1,P2RY12,GBE1,PLAU,CHI3L1,SGCD,MMP9	96	
Cell Death and Survival, DNA Replication, Recombination, and Repair	fragmentation	fragmentation of DNA	1.83E-07	 	0.395	 	0.204	NPM1,APOE,LEP,DDIT3,VPS28,MSR1,UBQLN1,PAM16,CTSG,ADIPOQ,CXCL12,PPIA,HRAS,FAS,CD28,KEAP1,TOP2A,TGFB2,SERPINA1,NACC1,GSK3B,PRNP,CD53,BIRC7,CNR1,TIAL1,SOD1,TPSAB1/TPSB2,APP,GRN,ENO1,BCL2L1,BSG,CSF1,DUSP1,MAPT,PPT1,RTN4,CAPN2,ADCYAP1	40	
Organismal Injury and Abnormalities	cytosis	Cytosis	1.83E-07	Decreased	-2.675	bias	-0.825	SOCS3,PLP1,RRM2B,CXCL12,SH3GLB1,CERS2,SLC29A3,ABR,SPTB,ANXA7,TUBA1C,STAM,GSK3B,RET,CLCN3,SPP1,LAIR1,ACP2,TUBB2A,PSMC4,NR1H3,ARSA,HAX1,OSTM1,BCL2L1,DNAJC5,BSG,DUSP1,IL1RN,SH2B3,MAPT,CTSB,CLCN7,SQSTM1,ESR2,STEAP3,POLE3,ABHD12,APOE,PRDX1,NQO2,ADIPOQ,HIF1A,KCNMA1,KIT,EGLN3,PRKCE,HPGDS,NFE2L2,ATP13A2,NDUFS4,IL11RA,PRNP,CALR,FCGR2A,TUBB4B,TUBG1,MGAT5,SOD1,CSF1R,APP,GRN,ITGB2,CSF1,SLC33A1,TREM2,PPT1,PSAP,MMP9	69	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	metastatic non-small-cell lung cancer	metastatic non-small-cell lung cancer	1.97E-07	 	 	 	 	EEF1A1,SEC61G,NDUFB4,TUBB4B,TUBG1,TUBB2A,PPIA,RNASE1,ATIC,RPS11,FAS,FTL,HSP90AB1,ERBB4,EIF4A1,TOP2A,IFI30,TUBA1C,RET,TMSB10/TMSB4X,CLCN3,MYL12A,POLE3,ALK	24	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	microtubule dynamics	1.97E-07	Increased	3.257	bias	-0.599	C1QA,SLC9A1,CLIP1,LTF,GLB1,DGKG,PRKY,GNA13,LCP1,CNR1,FLOT1,FGFR2,TPM3,NDN,FSCN1,BTG2,ATMIN,PRKACA,GAPDH,ADCYAP1,ACTG1,APOE,NME1,PLXNA3,GDF15,ADIPOQ,SDK1,CETN2,ARF6,ACTR3,S100A1,TNFRSF1A,GNA12,PVR,CPEB4,RNF6,MYO5A,GRN,FOS,MYOC,NTRK3,CSF1,BMP6,EEF1A1,NCDN,SEPT9,EML4,MBP,NNMT,RHOG,HOXA7,CDC42EP1,HDAC2,PTPRQ,CNP,MAPK8IP2,LAMA2,RAPGEF3,CAPG,ARSA,SMPD2,TXNRD1,MATN2,CAPN2,SIRPA,UBE2I,SULF1,FLRT1,PHLDB2,HNRNPK,SHC1,TWF2,LOC102724428/SIK1,KLHL42,DNAAF1,RPS3,LASP1,CAPZB,TUBG1,NQO1,DVL1,SOD1,KIF3B,ZPR1,FGF1,KIFC3,CAPNS1,KIF5B,TTL,TBC1D7,CTGF,ITGA8,MARK1,RAN,HRAS,KPNA1,BBS1,DYNLL1,CTSS,ABCC1,KIF21A,TESK1,RIMS3,CFL1,ROR1,NINJ1,BSG,STIP1,RTN4,LRP8,CDK2AP2,CYR61,RALA,BTG3,CDK16,SDC3,DCLK1,ENAH,UCHL1,DCLK2,UST,RHOD,SRGAP1,ACAP2,SNX10,PRKCE,TUB,NPTXR,IL11RA,PLAT,PTPRK,EGR1,ACTB,ARL3,APP,SREBF1,TENM4,ADCY1,FKBP4,ARAP1,ATXN10,P2RY12,PLAU,GABARAP,RUFY3,MAPRE3,NCAM1,PFN1,PTPN23,MAP1B,UNC5B,CXCL12,SDC4,DYNLT1,TUBB,NR2F1,COMT,MID1IP1,NEO1,C1QBP,GSK3B,RET,KLF2,DSP,FERMT3,RAB10,LMCD1,CDC42,MAPT,MAPK10,NUAK1,RARRES3,UHMK1,STXBP5,ARL2,LEP,GEM,RNF165,EPB41L3,PDGFA,VAPA,PKM,UGCG,FAS,TNFRSF12A,CCDC88A,DKK3,FLNA,THBS1,ERBB4,EFNB1,MICALL1,KIT,NSMF,ARHGEF2,SHANK2,MAPKAPK2,PI4KB,PRNP,SEMA3E,MAP3K1,F13A1,PLXND1,CSF1R,LPAR1,EPHB3,RTN3	207	
Infectious Diseases	viral entry	viral entry of carcinoma cell lines	1.98E-07	Increased	2.714	bias	 	ATP6V0C,DUSP3,ATP6V0B,FGFR2,MAP2K3,GSK3B,CSNK2B,ATP6V1A,ATP6AP1,ATP6V1B2,COPG1	11	
Infectious Diseases	viral entry	viral entry of lung cancer cell lines	1.98E-07	Increased	2.714	bias	 	ATP6V0C,DUSP3,ATP6V0B,FGFR2,MAP2K3,GSK3B,CSNK2B,ATP6V1A,ATP6AP1,ATP6V1B2,COPG1	11	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of fatty acid	2.09E-07	Increased	2.494	bias	0.013	SOCS3,APOB,PLP1,CD4,CXCL12,SLC27A4,SGPL1,PTGES2,LTF,ABCC1,HOXA10,FAR2,MID1IP1,TXN,GPC1,ACSL3,CNR1,NR1H3,ELOVL1,PLAA,IL1RN,MAPK10,CD14,ME2,AKR1B1,ESR2,HACD3,CYP4A11,SCD,APOE,LEP,PKM,ADIPOQ,CFTR,CD83,TECR,TACR1,C1QTNF3,HMOX1,PARK7,ANXA1,ERBB4,KIT,HPGDS,PRNP,CD209,CYP27A1,EDNRB,TNFRSF1A,FCGR2A,EGR1,MAP3K1,ALOX5AP,TRIB3,SOD1,CEBPB,DEGS1,APP,MYO5A,SREBF1,CSF1,APOC1,FCER1G,BMP6,NCAM1	65	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of central nervous system	2.10E-07	 	-1.769	 	-1.390	APOE,ADIPOQ,PSMC4,SH3GLB1,SOD1,CERS2,APP,GRN,CSF1,PPT1,MAPT,CLCN7,GSK3B,SQSTM1,HPGDS,NFE2L2,ATP13A2,NDUFS4,PRNP	19	
Carbohydrate Metabolism	quantity	quantity of carbohydrate	2.13E-07	Increased	2.678	 	1.674	GFPT1,CTGF,CA5B,VAC14,HRAS,C1QA,LTF,ABCC1,GAA,ATF4,RGL1,CPA3,PCK1,ELOVL1,GAPDH,ADCYAP1,ESR2,STEAP3,APOE,PPP1R3C,GDF15,ADIPOQ,HEXA,PROX1,G6PC3,OGT,ARF6,CES1,ANXA5,PLIN2,DCXR,SRA1,SLC25A13,UCP2,TNFRSF1A,DGAT2,APP,ITGB2,SREBF1,CSF1,NR4A1,FCER1G,PLAU,SIM1,ADRA1A,EEF1A1,PFKFB1,ARF1,SDC4,NPC1L1,HSPA5,SLC27A4,CERS2,HS6ST1,CXCL14,CHST11,ABCB11,C1QBP,GSK3B,CLCN3,KLF2,HK1,SPP1,FSTL3,XYLT1,RAPGEF3,FIG4,THRA,TPSAB1/TPSB2,SLC3A2,OSTM1,ADRA2A,IGFBP3,CD14,NUAK1,IGFBP4,SCD,TFEB,LEP,UGCG,HIF1A,GANAB,FAS,HINT1,STK40,PI4KB,CALR,NPY1R,NQO1,MGAT5,SOD1,SLC5A3,NRBF2,THRSP,FGF1,CIDEA,DGKQ,APOC1,NUCB2,GBE1,MMP9	101	
Cancer, Organismal Injury and Abnormalities	carcinoma	advanced stage carcinoma	2.21E-07	 	 	 	 	EEF1A1,RNASE1,RPS11,POR,IFI30,TUBA1C,CLCN3,TMSB10/TMSB4X,RET,TBC1D2B,SPP1,MFAP5,TUBB2A,SLC12A7,FGFR2,BCL2L1,ALDH1A2,LRP8,SFRP1,TMEM176B,ESR2,GSTP1,ALK,POLE3,IGFBP4,SCD,GSTM5,ARL4C,FKBP1A,PPIA,HIF1A,FAS,COL15A1,HSP90AB1,KCNMA1,ERBB4,MCAM,TOP2A,DAB2,KIT,MYL12A,NDUFB4,SEC61G,TUBB4B,TUBG1,CSF1R,ATIC,FTL,C2orf88,EIF4A1	50	
Cellular Compromise, Cellular Function and Maintenance	endoplasmic reticulum stress response	endoplasmic reticulum stress response	2.41E-07	 	-1.234	 	-1.496	DDIT3,HYOU1,TMBIM6,HSPA5,UCHL1,HMOX1,CTSD,HSP90AB1,STUB1,CTSS,STC2,DNAJC4,GAA,HSPE1,ATF4,STIM1,GSK3B,NFE2L2,AMFR,STT3B,CALR,HSPH1,CEBPB,HSPD1,SOD1,HSPA2,SERPINH1,MAPT,DERL1,CTSB,CD14,AARS,SQSTM1,MMP9	34	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small-cell lung carcinoma	advanced non-small-cell lung carcinoma	2.49E-07	 	 	 	 	EEF1A1,PPIA,RNASE1,RPS11,FAS,HSP90AB1,ERBB4,IFI30,TOP2A,TUBA1C,TMSB10/TMSB4X,RET,CLCN3,MYL12A,NDUFB4,SEC61G,TUBB4B,TUBB2A,TUBG1,ATIC,FTL,EIF4A1,GSTP1,POLE3,ALK	25	
Gene Expression	expression	expression of RNA	2.87E-07	 	1.924	 	-0.421	NPM1,WHSC1,NPAS2,MNAT1,SLC9A1,ODC1,GNB1,GATAD2A,CCND3,EIF4G2,CSE1L,KEAP1,ETF1,ATF4,GNA13,LMX1A,AIF1,PPP1R1B,FGFR2,NDN,HAX1,PLAG1,HSPA8,PYGO2,MRPL17,BTG2,PRKACA,ATMIN,GAPDH,DUSP4,NHLH1,SQSTM1,ADCYAP1,ESR2,PCBD1,DEAF1,RPL41,KDM1B,EIF3K,APOE,NME1,HTATIP2,DDIT3,WDR61,ADIPOQ,LGALS9,PROX1,SMARCA4,OGT,ACTR3,FBXW11,DAB2,NFE2L2,S100A1,SRA1,MECOM,MT-TY,MED20,TNFRSF1A,FCGR2A,GNA12,TRIB3,RNF6,GRN,FOS,MARCKSL1,AFF3,MYOC,MRPS7,PIR,NTRK3,CSF1,MBD3,NR4A1,WBP2,RPL37,SOX9,BMP6,SIM1,ID4,SOCS3,TRAF3,MBP,RACK1,NME2,OGFOD1,CBX5,CEBPG,CD28,HSPA4,RHOG,STC2,HOXA10,HOXA7,CHMP1A,FSTL3,HDAC2,YWHAB,CBX6,HNRNPAB,PFDN5,MT-TC,EIF2B3,RAPGEF3,CREG1,POLR2K,THRA,CITED1,EIF4E2,KLF4,TXNRD1,FOSB,AES,DUSP1,XRCC6,RBX1,ALDH1A2,IGFBP3,H1F0,IRF8,CCPG1,CBX3,UBE2I,ETV5,PEBP1,PTGFR,DDX21,LITAF,TFEB,ZNF219,LEO1,EIF2S1,HNRNPK,MLH1,IRAK1,FARSB,SHC1,PSMD10,STUB1,MED15,MT-TS1,RPS3,CRYM,SLC20A1,PATL1,PREB,VCAM1,TP63,EDNRB,TUBG1,DVL1,NQO1,CSRNP1,DNAJC1,RPS29,NRBF2,NFE2L1,ZPR1,FGF1,RBCK1,KCTD13,DGKQ,HMBOX1,MAP4K4,FHL5,NR6A1,CTGF,APOB,MAF,HRAS,MIF4GD,GSS,SNX12,ZBTB7B,POU6F2,MED16,CHCHD2,TXN,ZBTB16,NANOS1,NR1H3,JUNB,HMGA1,MTPN,NR1D1,ADM2,ARHGAP35,MAP2K3,LRP8,SFRP1,TCF7,CYR61,PDCD5,GSTP1,RPL24,MSC,RALA,RPS3A,TCEA1,PSMB10,BTG3,LRP6,HMGN1,FKBP1A,RUVBL1,CCAR2,DCLK1,SP2,H2AFZ,MAFG,DCLK2,C1QTNF3,SEC61A1,PHB,TOP2A,TRIM16,TUB,PRKCE,NACC1,PSMD14,RPS5,SARS,ACVR1C,MT-TD,RPS24,PTPRK,EGR1,TRIM28,RPL17,CSRNP2,TIAL1,CASK,RNASEK,APP,EIF3G,MRPL51,CCDC85B,GLIS2,SREBF2,LIMS1,SREBF1,USP22,RNF187,PEA15,PRMT5,NR5A2,DVL3,CBX4,MT-RNR1,MAPRE3,NCAM1,NAB2,HOXB5,GAB2,RGMA,PLP1,GTF3C6,PFN1,CD4,XPO5,UTP4,TAF10,MTCH2,NR2F1,CTBP1,PAX5,CAMK2D,PTGES2,PABPC4,CDON,EIF5,RPL19,NEO1,ANXA7,GSK3B,C1QBP,LPIN2,RET,KLF2,EIF2AK1,SPP1,FST,LMO4,POLR1A,GPS2,GNG2,CDK6,PHB2,SHOX,PKN1,EPRS,LMCD1,ERP29,CDC42,SH2B3,MAPK10,RARRES3,RPL13A,CNBP,MT-TP,CREBL2,SPX,GEM,LEP,SFRP2,ATF5,PDGFA,VAPA,RBBP8,ILF2,HIF1A,FAS,MT-TN,NELFE,SOX17,HINT1,NLK,PARK7,FLNA,DKK3,ERBB4,TGFB2,KIT,ARHGEF2,NR2F6,KCTD1,MAPKAPK2,TRAF7,CALR,TAF6,BHLHE41,HSPH1,MAP3K1,RPL30,ZBTB7C,CEBPB,NFKBIZ,NDUFA13,EDF1,ENO1,RPS4Y1,WARS,LPAR1,RPS27L,UTP15,CPEB1,HLTF,CARM1,RPL38	349	
Metabolic Disease, Neurological Disease, Psychological Disorders	Alzheimer's disease	Alzheimer's disease	2.90E-07	 	 	 	 	CTGF,RAN,NCSTN,ADGRL1,EEF1G,LGMN,CTSS,ATF4,TXN,UNG,PLD3,CNR1,PPTC7,HMGA1,CD68,MS4A4A,STIP1,CTSB,PRKACA,GAPDH,LRP8,PLTP,FH,ESR2,SORL1,APOE,DDIT3,UBQLN1,PRDX1,LRP6,UCHL1,LIPA,PRKCE,SERPINA1,NFE2L2,PLAT,FCGR2A,TYROBP,ACTB,SLC6A6,APP,FIS1,MT-ND1,NTRK3,SREBF2,SREBF1,LIMS1,PSAP,TSPO,PLAU,BMP6,ADRA1A,CLUH,GAB2,RACK1,CXCL12,TUBB,HSPA5,BIN1,CTSD,PACS2,GSK3B,IGFBP6,MACROD1,GM2A,CNP,HSPA9,GCNT2,HNRNPAB,EPRS,ADAM12,ADRA2A,MAPT,SLC7A2,IGFBP3,MAPK10,CD14,STXBP5,PHF1,DOK5,SCD,LEP,HIF1A,EIF2S1,MT-TN,HMOX1,BCYRN1,STUB1,SENP3,IGSF8,PRNP,MT-CO1,NQO1,SOD1,HSPD1,SERPINE2,CXCL16,TMEM2,APLP2,APOC1,CHI3L1,RTN3,MMP9	103	
Cell Morphology	cell spreading	cell spreading	3.12E-07	Increased	3.872	bias	1.680	RAP2B,PFN1,RACK1,CXCL12,HRAS,SDC4,SLC9A1,CLIP1,CD28,RHOG,ITGAV,GSK3B,TESK1,FERMT3,SPP1,CNR1,LAMA2,RAPGEF3,FYB,SMPD2,CDC42,MAPT,RTN4,CAPN2,CYR61,TFPI,SIRPA,CD151,GEM,MSR1,PDGFA,CDH11,SYNM,IRAK1,UCHL1,ARF6,SORBS1,FLNA,RHOD,THBS1,CSPG4,EFNB1,DAB2,PRKCE,PRNP,VCAM1,EDNRB,FCGR2A,MGAT5,PVR,ITGB2,COL5A3,LPAR1,FLNC,ARAP1,P2RY12,PLAU,MMP9,MAPRE3	59	
Cancer, Organismal Injury and Abnormalities	epithelial cancer	epithelial cancer	3.31E-07	 	0.060	 	0.357	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,SYT17,DCAF12,RNPEPL1,SRPRA,ANXA2,RPH3A,PLAG1,MYL9,RCC2,CD300C,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,AMOT,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,GCSH,DERL1,NR4A1,WBP2,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,HS6ST1,LHFPL2,STRN4,STC2,ANKDD1A,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,RBX1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,SUMO3,ZC3H7B,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,VAT1,RPS15,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,RAP2B,TUBA1B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,KLF8,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,HMGA1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,MRPL30,SDC3,H2AFZ,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CD53,CD209,NAP1L4,SLC25A13,RRP1B,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,CLTC,RPL29,IRX6,ANKMY2,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,TARS,SLC39A3,GALNT13,ATP6V1A,TPSAB1/TPSB2,TMEM189,YIF1A,CYP4A11,AKR7A2,UTP11,FPR3,GEM,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,SZRD1,RPS21,CEBPB,SYNPO2,ANO2,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,RAB38,SPTB,PLEKHO2,STAM,MGAT1,GNG12,ALDOC,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,SQSTM1,CHD1L,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,C9orf24,HN1,SEC23B,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,TRAF3,NCDN,TPPP3,MEGF9,USP5,SLC41A3,TMEM8A,PPFIBP2,ACO2,BAG3,NME2,MRPL47,RNASE1,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,GULP1,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,PSMD3,ARSA,TRIM35,FOSB,SDCBP,DNAJC5,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,PYCARD,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,DNAJC4,FYTTD1,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,TBC1D7,CHI3L1,SPCS1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ZNF592,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,SERINC2,NUGGC,DHRS9,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,P2RY8,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,PSMB10,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,SP2,TAX1BP3,MACC1,DCLK2,LIPA,IFRD2,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,ADCK2,PEA15,PRMT5,P2RY12,RUFY3,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,IFI30,ACOT1,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,LMO4,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,MAPK10,HSPA13,ACOT4,UHMK1,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,MMP14,EPSTI1,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,REM1,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,NHLH1,PLTP,ADCYAP1,FTH1,EPHX1,EIF3K,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,PTRH1,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,RPS16,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SEPT9,PCDH18,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,C2orf83,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,MIIP,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,HSPB6,MT-CO1,PATL1,TP63,TRIM55,IPO4,TRIM2,TSN,KIF3B,APLP2,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,ARPC5,HOXA6,RAN,GHITM,GYG2,MKI67,EIF6,GSS,EXPH5,RPS11,BBS1,RAD23A,DUSP3,LGMN,AHSA1,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,RTN4,CCT3,ME2,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,SDCCAG3,CDH11,ENAH,NDUFB9,LYZ,CES1,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,MYL12A,PLXNA1,DDX3Y,NOL6,PTPRK,PPIF,LPCAT4,CSRNP2,TIAL1,PAICS,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,IMMT,SLC48A1,CCDC85B,GLIS2,SREBF1,BRINP2,RHBDD2,TREM2,USP22,APOL4,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,CD4,PRMT3,MYH15,UNC5B,MAP1B,TCEB2,CD63,METAP2,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,RPL19,POMP,ANXA7,GSK3B,GPC1,PHPT1,C1QBP,RET,BCKDK,DSP,MRPS15,PCNXL2,C7orf50,MFSD3,HK1,SLC4A5,FERMT3,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,CD14,NUAK1,RARRES3,CLCN7,EIF5A,LFNG,TBC1D16,DNPEP,ARL2,CREBL2,SPIRE1,SRM,SFRP2,RAB1A,SH3RF3,CNRIP1,TOLLIP,KIAA1191,ATF5,ILF2,CD83,MRPS30,RRAGD,SLC39A1,ERBB4,HSPE1,OAZ1,MAPKAPK2,CACNG8,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,COL5A2,BHLHE41,HSPH1,PHLDA3,MAP3K1,R3HDM1,RNF43,OAF,VSIG4,GUK1,MRPS16,PLXND1,KIAA1683,PLBD2,C2orf88,TMEM2,CYC1,ASAP2,EPHB3,NUCB2,GBE1,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,TMSB10/TMSB4X,UNG,LCP1,UXS1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,BTG2,PSMA5,PRELP,GPR65,ATMIN,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,PHLDA2,OSGIN1,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,LURAP1L,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,HSPA2,SPTLC3,GRN,GIN1,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,CCT7,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,LACTB,BCAS2,C20orf27,YWHAB,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,PIK3AP1,MRPS2,IRF8,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SF3B5,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,REXO2,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,CAPZB,NPY1R,ZNF358,TUBG1,HPS1,NQO1,PWWP2B,NDUFV3,EMD,TRPA1,LARP6,NRBF2,FGF1,PDAP1,SHB,CIDEA,KIFC3,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,AHCYL1,C9orf72,SGSH,MMEL1,LDB3,TXNL4A,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CPA3,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,STIP1,LMOD2,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,RPL35,SEC61A1,ACSM5,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,ADRM1,LETM1,DTX4,TYROBP,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,MTCH2,VDAC2,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,EIF2AK1,IGFBP6,C6orf132,DNASE2,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,PKM,VAPA,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,TNFRSF12A,EVC,TACR1,SOX17,SEPHS2,HMOX1,CCDC88A,NLK,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,COX17,CYP27A1,VANGL1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,SLC27A3,USP9Y,RTN3,SCAND1	1432	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive organ tumor	digestive organ tumor	3.56E-07	 	0.257	 	1.061	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,AMOT,TMEM123,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,DERL1,NR4A1,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DNAJC15,CBX5,LHFPL2,STRN4,STC2,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,COL6A1,F8,GID4,C16orf59,IGSF8,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,VAT1,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,RPLP0,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,NINJ1,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,SDC3,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CCDC68,CD209,NAP1L4,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,GOT1,AAGAB,COL27A1,FST,ACP2,POLR1A,PSMF1,CLTC,ANKMY2,IRX6,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,SLC39A3,GALNT13,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,SZRD1,CEBPB,SYNPO2,ANO2,EMP1,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,RAB38,SPTB,PLEKHO2,STAM,MGAT1,GNG12,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,DCTD,SMOC2,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,SIGMAR1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,NCDN,TPPP3,MEGF9,TMEM8A,SLC41A3,NTMT1,PPFIBP2,ACO2,BAG3,NME2,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,SDHC,THRA,CMSS1,ARSA,TRIM35,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,KDM5D,SLC33A1,PSMD2,TBC1D7,CHI3L1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,RPS2,TMEM9B,RIMS3,ZNF592,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,YARS,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,CDK16,CTNNA1,ACSF2,PFKL,SP2,MACC1,DCLK2,LIPA,SRGAP1,TBC1D12,PRKCE,NACC1,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,COL5A3,CLDN5,DOCK8,UQCR10,PRMT5,P2RY12,RUFY3,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,RPL9,UBE2D2,PLEKHH2,IL1RN,HSPA13,ACOT4,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,RBM18,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,PTRH1,SLC25A1,SPATS2L,PVR,CSTB,RNF6,MYO5A,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SEPT9,PCDH18,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,C2orf83,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,IGFBP4,DDX21,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,MT-CO1,PATL1,PREB,TP63,TRIM55,IPO4,TRIM2,TSN,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,HOXA6,ARPC5,RAN,GHITM,GYG2,MKI67,GSS,EXPH5,BBS1,RAD23A,AHSA1,LGMN,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,RTN4,ME2,B3GNT5,SETBP1,GSTP1,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,SDCCAG3,CDH11,ENAH,LYZ,CES1,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,SLC30A1,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,TIAL1,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,SLC48A1,GLIS2,BRINP2,RHBDD2,SREBF1,TREM2,USP22,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,TCEB2,CD63,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,DHX32,MDH2,BCKDK,DSP,PCNXL2,C7orf50,MFSD3,HK1,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,RARRES3,NUAK1,CD14,CLCN7,LFNG,EIF5A,TBC1D16,DNPEP,ARL2,SPIRE1,SRM,SH3RF3,CNRIP1,TOLLIP,RAB1A,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,MAPKAPK2,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,MAP3K1,RNF43,R3HDM1,OAF,VSIG4,MRPS16,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,RPS4Y1,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,UNG,LCP1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,XIST,HSPA2,SPTLC3,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,BCAS2,C20orf27,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,REXO2,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NDUFV3,NQO1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,CADM3,SLC29A4,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,DGCR6L,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,MYH1,DNAH12,LETM1,ADRM1,DTX4,TYROBP,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,RPL13A,CEACAM21,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,EVC,TACR1,SEPHS2,SOX17,HMOX1,CCDC88A,NLK,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,CYP27A1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1304	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of neutrophils	3.80E-07	 	1.450	bias	-0.882	SOCS3,PLCB2,PLP1,CTGF,UNC5B,CTSG,CXCL12,CD28,CXCL14,CYBB,TXN,C1QBP,TMSB10/TMSB4X,PTX3,SPP1,FLOT1,CAPG,TPSAB1/TPSB2,DUSP1,IL1RN,RTN4,CTSB,CD14,PLTP,SFRP1,ADCYAP1,C3AR1,CD151,APOE,ADAM17,DAPK2,NQO2,ADIPOQ,CFTR,FAS,TACR1,HMOX1,ANXA1,SAA1,TGFB2,SERPINA1,STIM1,MAPKAPK2,GJB2,PLAT,VCAM1,TNFRSF1A,FCGR2A,NQO1,HYAL1,MGAT5,ALOX5AP,APP,GRN,ITGB2,MT-ND1,EDIL3,TNFAIP8L2,CSF1,FCER1G,PLAU,NCKAP1L,MMP9	63	
Organismal Development	size	size of body	3.90E-07	Increased	7.715	bias	 	PCLO,CA5B,MAF,SLC35C1,EIF6,SLC9A1,APRT,SPRY4,PTPRC,SGPL1,LGMN,CCND3,ST6GALNAC2,ATF4,SV2B,CENPB,TKT,CNR1,PTP4A3,DKC1,SURF1,FGFR2,ANXA2,PCK1,HMGA1,HAX1,SH3GL1,PYGO2,CTSA,BSG,PRKACA,ARHGAP35,LRP8,SFRP1,ACTG1,ESR2,SLC4A4,APOE,ADAM17,SLC4A2,GDF15,ADIPOQ,G6PC3,CETN2,LIPA,PLIN2,PRKCE,STIM1,SMPD3,NDUFS4,PLAT,MYH1,SLC25A13,TYROBP,TNFRSF1A,SLC6A6,DGAT2,POMGNT1,APP,FOS,COL5A3,LAMP2,NTRK3,CSF1,BMF,FCER1G,PEA15,FKBP4,PSAP,BMPER,PLAU,SIM1,NCAM1,NAB2,ICMT,TRAF3,PLP1,UBE2A,ARL6IP5,MAP1B,GPC3,PNRC2,SLC27A4,CTBP1,CTSD,HS6ST1,STC2,CDON,ENTPD5,CXCL14,CYBB,ABCB11,ANXA7,MTMR2,CLCN3,SPP1,FST,DNASE2,HDAC2,SGCG,LAMA2,MAPK8IP2,CDK6,SLC12A7,RAPGEF3,THRA,FOSB,DNAJC5,ADCYAP1R1,DUSP1,IL1RN,XRCC6,ALDH1A2,IGFBP3,CLCN7,LFNG,H1F0,SIRPA,ETV5,SULF1,SUMO3,IGFBP4,LEP,SFRP2,PDGFA,PPIB,MMP14,SLC7A1,CFTR,HMOX1,HINT1,PREPL,STUB1,KCNMA1,PHYH,TGFB2,SHANK2,ALPL,LASP1,RAD23B,COL5A2,TPST2,NPY1R,NQO1,SOD1,SLC5A3,CSF1R,APLP2,PLCB4,ITPA,LPAR1,MMP9	152	
Nucleic Acid Metabolism	metabolism	metabolism of nucleic acid component or derivative	4.09E-07	Increased	2.404	bias	0.260	GFPT1,COX8A,RRM2B,HRAS,APRT,POR,GNB1,GNA13,AHCY,CALCRL,CNR1,SURF1,CTPS1,HSPA8,GPR65,ALDOA,ADM2,ADCYAP1,APOE,ATP5G1,ATP5H,CHCHD10,CES1,DCXR,ATP5J2,OAS1,SLC25A13,LETM1,UCP2,PPIF,IMPDH2,CYP1B1,APP,MRAP,ADCY1,P2RY12,CYCS,BMP6,SOCS3,ICMT,ATP5D,DPM1,NME2,ATP5L,TYMP,SLC27A4,NNMT,PGD,AK1,G0S2,UQCC2,COMT,ENTPD5,ACOT1,NDUFS6,MDH2,SPP1,GLYAT,TALDO1,ERH,OLA1,ADRA2A,ADCYAP1R1,MAPT,ACOT4,VDAC1,PPAT,RPSA,LEP,RAB4A,PKM,CFTR,HIF1A,ME1,REXO2,FAS,HMOX1,SHC1,THBS1,BHMT2,OGDH,LONP1,PRNP,ADCY2,MT-ATP6,USMG5,NQO1,GABBR1,SOD1,CEBPB,GUK1,HSPD1,ATIC,LPAR1,ITPA,NUCB2,PANK3,SLC25A5	98	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of macrophages	4.19E-07	 	0.302	bias	-1.640	NAB2,NPM1,PLP1,PFN1,CTGF,CTSG,CXCL12,HRAS,CYBB,STAB1,PTX3,SPP1,CNR1,CNP,NINJ1,IL1RN,SH2B3,PLTP,CYR61,C3AR1,RPL13A,APOE,ADAM17,LITAF,LEP,NQO2,ADIPOQ,HIF1A,G6PC3,HMOX1,CCDC88A,CES1,GBA,FLNA,THBS1,ANXA1,DUSP10,SAA1,EGLN3,MAPKAPK2,NFE2L2,PRNP,SEMA3E,EDNRB,TYROBP,NQO1,PLXND1,CSF1R,APP,ITGB2,TNFAIP8L2,GLIS2,CSF1,SREBF1,TREM2,PLAU,C6	57	
Infectious Diseases	viral entry	viral entry of tumor cell lines	4.30E-07	Increased	2.687	bias	0.950	CD209,ATP6V0C,ATP6V0B,CD4,FGFR2,ATP6V1A,ATP6AP1,COPG1,DUSP3,ITGAV,MAP2K3,GSK3B,CSNK2B,ATP6V1B2	14	
Free Radical Scavenging	production	production of reactive oxygen species	4.52E-07	 	-0.268	 	-1.580	TRAF3,RACK1,CTSG,CXCL12,HRAS,TMBIM6,CD28,LTF,ALDH3A2,ABCC1,CYBB,UQCRFS1,HK1,SPP1,SESN3,HSPA9,RAPGEF3,THRA,ARSA,CD52,TXNRD1,BCL2L1,CDC42,TXN2,MAPT,RTN4,CD14,SQSTM1,VDAC1,ADCYAP1,AKR1B1,ESR2,FTH1,APOE,LEP,MSR1,DDIT3,UBQLN1,PRDX1,ADIPOQ,PPIA,HNRNPK,FAS,LIPA,HMOX1,SHC1,PARK7,PHB,HSP90AB1,ANXA1,PRKCE,SHANK2,LONP1,NFE2L2,HSPB6,PRNP,MT-CO1,SIGMAR1,VCAM1,LETM1,UCP2,TYROBP,FCGR2A,ACTB,SOD1,APP,GRN,ITGB2,FTL,IMMT,CSF1,NR4A1,ARHGDIA	73	
Cardiovascular Disease, Hematological Disease	anemia	anemia	4.65E-07	Decreased	-3.429	bias	 	NPM1,SLC7A11,RRM2B,GSS,PTPRC,CD28,AK1,LGMN,CCND3,SPTB,ATF4,LPIN2,C1QBP,MGAT1,RAD51C,KLF2,HK1,EIF2AK1,DNASE2,HDAC2,GSTM3,CDK6,SLC12A7,DGKE,TSPAN33,CD52,TXNRD1,BCL2L1,CCND2,SH2B3,ALDOA,TFRC,TFPI,ESR2,STEAP3,APOE,TCEA1,PRDX1,CUBN,SEC23B,SLC7A1,RPL26,GPC4,HIF1A,FAS,FANCE,HMOX1,ARF6,ANXA1,KIT,NFE2L2,RPS24,SLC20A1,MT-CO1,RPS19,VCAM1,EDNRB,IMPDH2,FCGR2A,TUBB4B,TRIM28,EGR1,NQO1,RPS10,SOD1,RPS29,NFE2L1,ITPA,YARS2,FCER1G,TPP1,P2RY12	72	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders	familial dementia	familial dementia	4.93E-07	 	 	 	 	SORL1,APOE,CHCHD10,C9orf72,SOD1,CSF1R,APP,GRN,CTSD,LIPA,MT-ND1,PARK7,MAPT,APOC1,MAPK10,SQSTM1	16	
Nucleic Acid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of purine nucleotide	4.98E-07	Increased	2.066	bias	-0.092	APOE,SOCS3,ATP5G1,ATP5D,CHCHD10,COX8A,PKM,NME2,ME1,HIF1A,FAS,SLC27A4,NNMT,HMOX1,AK1,G0S2,UQCC2,NDUFS6,LONP1,SLC25A13,OAS1,MT-ATP6,UCP2,LETM1,PPIF,USMG5,IMPDH2,SURF1,SOD1,HSPD1,APP,MAPT,ALDOA,PANK3,NUCB2,CYCS,SLC25A5,VDAC1,ADCYAP1,PPAT	40	
Inflammatory Disease	chronic inflammatory disorder	chronic inflammatory disorder	5.22E-07	 	-1.294	 	-0.908	C9orf72,MMEL1,CTSG,C1QA,CLSTN2,MNAT1,PANX1,GSS,EEF1G,PTPRC,POR,DYNLL1,IP6K3,LTF,GAA,ATF4,CHCHD2,TXN,AIF1,LCP1,CALCRL,MSMO1,FGFR2,NR1H3,HSPA8,TMEM127,CD68,BSG,CNTNAP4,IL10RA,MS4A7,CTSB,ALDOA,TFRC,GLUL,C3AR1,FTH1,SORL1,APOE,ADAM17,DDIT3,HLA-A,PRDX1,BAG6,HSPB8,ADIPOQ,LGALS9,ST6GALNAC4,FKBP1A,GPC4,SDC3,CDH11,UCHL1,LYZ,TNXB,TOP2A,PRKCE,HPGDS,FKBP5,ALPK2,RPL31,MYL12A,RPS24,S100A1,TNFRSF1A,IMPDH2,FCGR2A,TRIM28,DGAT2,SPATS2L,APP,GRN,FOS,ITGB2,RPS16,CSF1,TENM4,NR4A1,TSPO,NR5A2,ADRA1A,SOCS3,SLC7A11,KCND3,ARF1,PRMT3,CD4,CXCL12,TYMP,SDC4,HSPA5,NRSN2,CD28,CTSD,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,CYBB,STAB1,LPIN2,RPL32,PSMB5,SPP1,DNASE2,HDAC2,LMO4,ERH,CDK6,RAB10,CAPG,PPP1R11,THRA,FOSB,SEL1L,BCL2L1,ADRA2A,DUSP1,IL1RN,SLC7A2,NAGLU,PPAT,RPSA,IGFBP4,LEP,PRDX5,PYCARD,PKM,SLC7A1,CFTR,CD83,FAS,NELFE,EVC,TACR1,HLA-G,HMOX1,SLFN5,RPL18A,CCSER2,THBS1,ANXA1,MCAM,EFNB1,SAA1,TGFB2,RPS3,MAPKAPK2,ALPL,PRNP,CALR,VCAM1,R3HDM1,GABBR1,VSIG4,HSPD1,CEBPB,ATIC,FAU,FGF1,CXCL16,ENO1,APLP2,ITPA,DIP2C,PSMD2,CHI3L1,MAP4K4,MMP9	171	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of muscle cells	5.28E-07	Increased	2.889	 	1.462	SOCS3,CMA1,CXCL12,HRAS,SDC4,MNAT1,SLC9A1,ODC1,CAMK2D,PLCE1,COMT,TXN,GSK3B,AIF1,CALCRL,SPP1,FST,HDAC2,KCNK2,CDK6,FGFR2,JUNB,NPY5R,KLF4,DUSP1,IL1RN,ALDH1A2,IGFBP3,CTSB,CAPN2,TFPI,AKR1B1,ESR2,C3AR1,SIRPA,IGFBP4,APOE,ADAM17,FHL1,RAB1A,LEP,MMP14,NQO2,ADIPOQ,PPIA,HIF1A,H2AFZ,SMARCA4,IRAK1,TNFRSF12A,SHC1,HMOX1,CCDC88A,THBS1,KIT,HSD11B2,STIM1,NFE2L2,PLAT,PRNP,TNFRSF1A,EGR1,NQO1,EMD,ALOX5AP,HSPD1,CYP1B1,POMGNT1,FGF1,FOS,CXCL16,TNFAIP8L2,LPAR1,NR4A1,PLAU,MMP9	76	
Cardiovascular Disease	atherosclerosis	atherosclerosis	6.22E-07	 	-0.095	 	-0.947	SOCS3,PLIN1,SLC7A11,APOB,PFN1,ITGA8,MKI67,SDC4,NPC1L1,SLC9A1,GSS,NNMT,CTSS,GAA,COMT,ITGAV,TUBA1C,GCLM,KLF2,PTX3,SPP1,SGCG,TKT,CNR1,TUBB2A,NR1H3,JUNB,RASL12,KLF4,FOSB,ADRA2A,VKORC1,MATN2,RTN4,CD14,LRP8,PLTP,ESR2,SCD,APOE,LEP,MSR1,MMP14,LRP6,GDF15,ADIPOQ,FKBP1A,HMOX1,SHC1,CES1,SORBS1,THBS1,PLIN2,SAA1,F5,OGDH,NFE2L2,PLAT,SIGMAR1,VCAM1,COL5A2,CYP27A1,MECOM,TNFRSF1A,TUBB4B,IMPDH2,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,SOD1,HSPD1,APP,FOS,CXCL16,ITGB2,MTHFD1L,LAMP2,SUPV3L1,CSF1,APOC1,NR4A1,P2RY12,GBE1,PLAU,CHI3L1,SGCD,MMP9	90	
Cardiovascular Disease	arteriosclerosis	arteriosclerosis	6.35E-07	 	-0.234	 	-0.991	SOCS3,PLIN1,SLC7A11,APOB,PFN1,ITGA8,MKI67,SDC4,NPC1L1,SLC9A1,GSS,NNMT,CTSS,GAA,COMT,ITGAV,TUBA1C,GCLM,KLF2,PTX3,SPP1,SGCG,TKT,CNR1,TUBB2A,NR1H3,JUNB,RASL12,KLF4,FOSB,ADRA2A,VKORC1,MATN2,RTN4,CD14,LRP8,PLTP,ESR2,SCD,APOE,LEP,MSR1,MMP14,LRP6,GDF15,ADIPOQ,FKBP1A,HMOX1,SHC1,CES1,SORBS1,THBS1,PLIN2,SAA1,F5,OGDH,MAPKAPK2,NFE2L2,PLAT,SIGMAR1,VCAM1,COL5A2,CYP27A1,MECOM,TNFRSF1A,TUBB4B,IMPDH2,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,SOD1,HSPD1,APP,FOS,CXCL16,ITGB2,MTHFD1L,LAMP2,SUPV3L1,CSF1,APOC1,NR4A1,P2RY12,GBE1,PLAU,CHI3L1,SGCD,MMP9	91	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities	hereditary neuropathy	hereditary neuropathy	6.43E-07	 	 	 	 	APOE,LITAF,PLP1,PFN1,C9orf72,CHCHD10,SEPT9,GARS,HSPB8,UCHL1,PARK7,MT-CYB,ERBB4,KIF1A,CHCHD2,MTMR2,ATP13A2,HK1,MT-CO1,SIGMAR1,MT-ATP6,SPG21,SURF1,RAB7A,FIG4,TRIM2,SOD1,HSPD1,MARS,GRN,BCL2L1,MT-ND5,MT-ND1,SLC33A1,YARS,MAPT,NAGLU,PSAP,AARS,SQSTM1,SCN11A,MPV17,MMP9	43	
Infectious Diseases	viral entry	viral entry by Influenza virus	7.03E-07	Increased	2.714	bias	 	ATP6V0C,DUSP3,ATP6V0B,FGFR2,MAP2K3,GSK3B,CSNK2B,ATP6V1A,ATP6AP1,ATP6V1B2,COPG1	11	
Cell Death and Survival, Neurological Disease	cell death	cell death of cerebral cortex cells	7.68E-07	 	-0.456	 	-0.421	MAP1B,SH3GLB1,HSPA5,CTSD,GSK3B,GCLM,UNG,YWHAB,CDK6,JUNB,BCL2L1,ADAM12,DUSP1,IL1RN,CDC42,STIP1,MAPT,MAPK10,GAPDH,MAP2K3,ADCYAP1,APOE,LEP,DDIT3,UBQLN1,VAPA,HYOU1,HIF1A,FAS,PARK7,GBA,TCP1,RPS3,NFE2L2,ATP13A2,PRNP,PLAT,SRR,TP63,UCP2,TNFRSF1A,MAP3K1,SOD1,HSPD1,APP,CAPNS1,NTRK3,PEA15,CYCS	49	
Cell-To-Cell Signaling and Interaction	binding	binding of cells	7.87E-07	Increased	2.437	bias	0.035	CD4,CTSG,CXCL12,HRAS,SDC4,HSPA5,GPC3,PTPRC,CD28,HS6ST1,LTF,CCT5,ITGAV,SLC7A5,STAB1,CDC42EP1,GSK3B,GPC1,C1QBP,SNU13,PTX3,FERMT3,CALCRL,SPP1,LAMA2,ANXA2,ARSA,FYB,SLC3A2,CD68,ADRA2A,STIP1,IGFBP3,ALCAM,TFRC,CD14,CCT3,LRP8,LFNG,IRF8,CYR61,TFPI,ADCYAP1,CD151,RPSA,SORL1,APOE,LEP,MSR1,SCARA5,HLA-A,LRP6,ADIPOQ,CFTR,CD83,FAS,TNFRSF12A,CCT4,F8,THBS1,EFNB1,ERBB4,ANXA5,F5,TGFB2,KIT,TCP1,SEMA3B,NFE2L2,PRNP,SIGMAR1,CALR,CD209,VCAM1,FCGR2A,VANGL1,DNAJC1,PVR,FGF1,APP,ITGB2,CLGN,SCARA3,DOCK8,CSF1,NR4A1,CCT7,PRMT5,P2RY12,CLDN2,PLAU	91	
Cell Death and Survival	cell viability	cell viability of neuroblastoma cell lines	9.16E-07	 	1.050	bias	-0.214	APOE,NPY1R,BAG3,HSPB8,SOD1,APP,HMOX1,BCL2L1,LYZ,HSP90AB1,SREBF2,DPP3,MAPT,CYBB,PSAP,GPC1,SQSTM1,ATP13A2,PRNP	19	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	cellular infiltration by macrophages	9.31E-07	 	-1.139	 	-2.202	APOE,ADAM17,CTGF,PLP1,LEP,NQO2,ADIPOQ,HRAS,HIF1A,HMOX1,CES1,GBA,ANXA1,DUSP10,SAA1,CYBB,EGLN3,NFE2L2,SEMA3E,PTX3,SPP1,CNR1,CNP,NQO1,CSF1R,NINJ1,APP,ITGB2,TNFAIP8L2,GLIS2,IL1RN,CSF1,SREBF1,PLTP,PLAU,C6,CYR61,RPL13A	38	
Cell Death and Survival	necrosis	necrosis of epithelial tissue	9.74E-07	 	-0.452	 	-0.804	NPM1,ASS1,HRAS,TMBIM6,SGPL1,DYNLL1,CTSS,ABCC1,MCOLN3,TXN,HAX1,PRKACA,CTSB,GAPDH,TFRC,MAP2K3,SFRP1,ESR2,ADAM17,DDIT3,PSMB10,NQO2,DUSP6,GDF15,ADIPOQ,CTNNA1,HSPB8,PPIA,LIPA,AAK1,DAB2,PRKCE,SERPINA1,NFE2L2,PLAT,UCP2,MECOM,TNFRSF1A,EGR1,TRIB3,APP,FOS,MYOC,EDIL3,GLIS2,NTRK3,BMF,FKBP4,NR4A1,PEA15,CYCS,PLAU,BMP6,SOCS3,ICMT,CD4,UNC5B,CXCL12,TYMP,HSPA5,CDON,ENTPD5,ITGAV,GSK3B,KLF2,HK1,SPP1,CNP,CDK6,DGKE,SDHC,BCL2L1,CDC42,IL1RN,MAPT,IGFBP3,VDAC1,CD151,SCD,LEP,PYCARD,UGCG,FAS,TACR1,SHC1,HMOX1,THBS1,SAA1,MCAM,SEMA3B,MAPKAPK2,ATP13A2,PRNP,SLC20A1,CALR,TP63,MAP3K1,SOD1,CEBPB,HSPD1,CSF1R,FGF1,RBCK1,EMP1,TNFAIP8L2,SLC25A5,MMP9,SLC47A1	108	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	quantity	quantity of glycosphingolipid	1.03E-06	 	0.783	 	0.086	SCD,APOE,PLP1,LEP,HRAS,UGCG,CFTR,FAS,SLC27A4,CERS2,GRINA,CTSD,ARF6,HINT1,GBA,GLB1,SMPD3,NSMAF,SMPD2,APP,B4GALT2,CSF1,NAGLU,PSAP,B3GNT5,PLTP	26	
Carbohydrate Metabolism	metabolism	metabolism of polysaccharide	1.10E-06	 	0.113	bias	-1.722	SOCS3,GFPT1,CTGF,SGSH,HRAS,HS6ST1,GYS1,LTF,CCND3,GAA,CHST11,GPC1,GSK3B,CLN6,SPP1,XYLT1,CLTC,GCNT2,RAB10,BSG,NR1D1,IL1RN,IGFBP3,CTSB,NAGLU,B3GAT3,SFRP1,APOE,SULF1,TFEB,B3GALT6,LEP,PPP1R3C,HS2ST1,ADIPOQ,HEXA,SORBS1,TGFB2,STK40,PLAT,ADCY2,HYAL1,PYGB,CEBPB,CSF1R,NTRK3,SREBF1,CSF1,NR4A1,GBE1	50	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	benign neoplasm of female genital organ	benign neoplasm of female genital organ	1.11E-06	 	 	 	 	RAP2B,NR6A1,SOCS3,TWF1,PLP1,MEGF9,RPE,AHCYL1,SCN7A,MAF,MRVI1,NR2F1,KEAP1,CXCL14,RPL19,ERAL1,WNT5B,SLC2A5,ALDH1B1,CALCRL,CAPN6,TBC1D2B,SPP1,PLD3,MFAP5,SLC24A3,CNP,RAPGEF3,AP2S1,RPL9,PPP2R1A,KCNG1,ADRA2A,ADAM12,ALDH1A2,ALDOA,ARHGAP35,LRP8,SFRP1,CYR61,ESR2,TMEM176B,FTH1,IGFBP4,APOE,GSTM5,PHLDA2,SCARA5,UQCRH,ARL4C,HN1,PKM,UGCG,SLC7A1,COL15A1,FAS,HSP90AB1,MCAM,KIT,MICALL1,DAB2,RPS19,DLGAP4,EDNRB,MECOM,DVL1,MAP3K1,HYAL1,GABBR1,SLC5A3,STXBP6,CYP1B1,FOS,RPS15,C2orf88,PLCB4,SLC33A1,NR4A1,NR5A2,ADRA1A,CLUH	81	
Cancer, Organismal Injury and Abnormalities	abdominal cancer	abdominal cancer	1.14E-06	 	0.269	 	0.739	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,LY6E,ALPK2,AMOT,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,GCSH,DERL1,NR4A1,WBP2,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,HS6ST1,LHFPL2,STRN4,STC2,ANKDD1A,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,SUMO3,ZC3H7B,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,TBL1Y,TXNDC12,FECH,SLC25A5,MAP4K4,RPLP0,RAP2B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,KLF8,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,HMGA1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,MRPL30,SDC3,ATP6AP1,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CD53,CD209,NAP1L4,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,GOT1,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,PSMF1,CLTC,RPL29,IRX6,ANKMY2,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,TARS,SLC39A3,GALNT13,TPSAB1/TPSB2,YIF1A,CYP4A11,AKR7A2,UTP11,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,SZRD1,CEBPB,SYNPO2,ANO2,EMP1,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,SPTB,PLEKHO2,STAM,MGAT1,GNG12,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,CD52,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,SQSTM1,CHD1L,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,HN1,SEC23B,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,SIGMAR1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,NCDN,TPPP3,MEGF9,USP5,TMEM8A,SLC41A3,PPFIBP2,ACO2,BAG3,NME2,MRPL47,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,GULP1,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,PSMD3,ARSA,TRIM35,FOSB,DNAJC5,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,KDM5D,HMBOX1,SLC33A1,PSMD2,TBC1D7,CHI3L1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ZNF592,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,CDK16,CTNNA1,ACSF2,PFKL,SP2,MACC1,DCLK2,LIPA,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,MFAP4,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,PEA15,P2RY12,RUFY3,MAPRE3,HOXB5,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,IFI30,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,MAPK10,HSPA13,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,REM1,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,PTRH1,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,SEPT9,PCDH18,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,PPAT,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,CRYM,HSPB6,MT-CO1,PATL1,TP63,TRIM55,IPO4,TRIM2,TSN,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,HOXA6,ARPC5,RAN,GHITM,GYG2,MKI67,EXPH5,BBS1,RAD23A,AHSA1,LGMN,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,RTN4,CCT3,ME2,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,CDH11,ENAH,LYZ,CES1,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,PPIF,LPCAT4,CSRNP2,PAICS,TIAL1,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,IMMT,SLC48A1,GLIS2,BRINP2,RHBDD2,SREBF1,TREM2,USP22,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,TCEB2,METAP2,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,MDH2,BCKDK,DSP,PCNXL2,C7orf50,MFSD3,HK1,SLC4A5,FERMT3,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,RARRES3,NUAK1,CD14,CLCN7,LFNG,TBC1D16,DNPEP,ARL2,SPIRE1,SRM,SH3RF3,CNRIP1,TOLLIP,RAB1A,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,MAPKAPK2,CACNG8,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,PHLDA3,MAP3K1,R3HDM1,RNF43,OAF,VSIG4,GUK1,MRPS16,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,RPS4Y1,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,TMSB10/TMSB4X,UNG,LCP1,UXS1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,TPM3,NPY5R,COX7A1,RASL12,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,BTG2,GPR65,ATMIN,GAPDH,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,PHLDA2,OSGIN1,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,XIST,HSPA2,SPTLC3,GIN1,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,BCAS2,C20orf27,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,CDH20,SLC25A39,LIMA1,IGFBP3,CAPN2,PIK3AP1,MRPS2,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,REXO2,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,NPY1R,ZNF358,TUBG1,HPS1,NQO1,PWWP2B,NDUFV3,EMD,TRPA1,LARP6,NRBF2,FGF1,PDAP1,CXCL16,SHB,CIDEA,SCARA3,KIF5B,NOP16,SLC36A1,COX5A,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,AHCYL1,C9orf72,SGSH,MMEL1,LDB3,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,DGCR6L,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,NANOS1,CFL1,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CPA3,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,STIP1,LMOD2,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,ADRM1,LETM1,DTX4,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,APP,AREL1,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,GABARAP,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,MTCH2,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,KLF2,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,PKM,VAPA,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,EVC,TACR1,SOX17,SEPHS2,HMOX1,CCDC88A,NLK,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,CYP27A1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1392	
Molecular Transport	quantity	quantity of metal	1.15E-06	Increased	2.360	bias	-0.050	RAP2B,PLCB2,SLC31A1,ARF1,CXCL12,HRAS,MRVI1,HSPA5,PANX1,SLC9A1,GNB1,PTPRC,CD28,CAMK2D,PLCE1,LTF,CPM,LYNX1,MCOLN3,CYBB,GNA13,C1QBP,EIF2AK1,SPP1,LAIR1,STK39,PPP1R1B,RAPGEF3,FIG4,ANXA2,TPSAB1/TPSB2,BCL2L1,ADCYAP1R1,ADRA2A,MAPT,PRKACA,TFRC,VDAC1,ADCYAP1,AKR1B1,C3AR1,TMOD1,STEAP3,FTH1,SLC4A4,PTGFR,APOE,LEP,F2RL3,PPIB,HLA-A,HYOU1,PPIA,FKBP1A,EIF2S1,FAS,TACR1,HMOX1,SHC1,LYZ,MCAM,SAA1,HSD11B2,STIM1,SLC30A1,HSPB6,PRNP,S100A1,SIGMAR1,CALR,VCAM1,EDNRB,FCGR2A,AP3D1,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,CISD1,MARCKSL1,FTL,APLP2,CSF1,FCER1G,NUCB2,CLDN2,BMPER,PLAU,ADRA1A,NCAM1	93	
Cellular Movement	cell movement	cell movement of breast cancer cell lines	1.23E-06	Increased	3.257	bias	1.117	GAB2,CTGF,PTPN23,SEPT9,ARF1,RACK1,CXCL12,HRAS,SDC4,CSE1L,ITGAV,TUBA1C,SPP1,GSDMB,FGFR2,ANXA2,ROR1,KLF4,FOSB,SDCBP,ADAM12,CDC42,IGFBP3,CAPN2,TFPI,ESR2,UBE2I,CD151,NME1,LEP,ARPC1B,OSGIN1,MMP14,RUVBL1,HIF1A,ENAH,GRINA,SHC1,CCDC88A,ARF6,FLNA,ANXA1,MCAM,SERPINA1,LASP1,NDUFAF3,S100A1,PLXNA1,BHLHE41,MGAT5,SNCG,FGF1,FOS,LPAR1,WBP2,PLAU,BMP6,ADAM9,MAP4K4,MMP9	60	
Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of actin cytoskeleton	1.24E-06	 	1.067	bias	0.391	VCAM1,COL5A3,ERP29,SLC4A2,CDC42,THBS1,FLNA,ACTB,RAPGEF3,PLAU,SYNPO2	11	
Infectious Diseases	replication	replication of Influenza A virus	1.26E-06	Increased	6.260	bias	 	EEF1A1,AHCYL1,PCDH18,RABEP1,TXNL4A,HRAS,MNAT1,TUBB,SGPL1,DUSP3,SAE1,CSE1L,STAB1,MID1IP1,GSK3B,FERMT3,PTX3,STK39,SNRPF,FGFR2,COPB1,ATP6V1A,NRBP1,CDC42,FSCN1,ATP6V0D1,PRKACA,MAP2K3,RPL13A,RPSA,ATP6V0C,ATP6V0B,GBP1,DAPK2,DCLK1,NAA10,ATP6AP1,DCLK2,RPL35,PSMD14,RPS5,LONP1,CD209,SIGMAR1,RPS10,F13A1,HSPD1,STX10,FAU,COPG1,EIF3G,RPS16,PSMD2,PLAU,MAP4K4,MMP9,ATP6V1B2,CLUH	58	
Hereditary Disorder, Organismal Injury and Abnormalities	autosomal recessive disease	autosomal recessive disease	1.36E-06	 	-1.145	bias	 	CSTA,JMJD8,GFPT1,APOB,TXNL4A,CA12,CTSG,C1QC,C1QA,C1QB,SLC9A1,GSS,APRT,EXPH5,BBS1,PTPRC,ABCC6,CECR1,POR,EMG1,CCND3,LTF,GAA,KIF1A,EARS2,CLN6,ZBTB16,UNG,AHCY,MPC1,ZNF592,AASS,HAX1,CTPS1,NOP10,DNAAF5,CCND2,PSMA4,RMND1,IL10RA,AARS,SQSTM1,B3GAT3,PCBD1,FKBP14,SLC4A4,ABHD12,ADAM17,SFXN4,DPM2,TECR,ASNS,G6PC3,SLC52A2,UCHL1,BANF1,GBA,PEX10,TOP2A,SNX10,SERPINA1,STIM1,GJB2,PLOD3,IL11RA,SIGMAR1,PLOD2,SLC25A13,FCGR2A,IMPDH2,CYP1B1,POMGNT1,APP,MRAP,MT-ND1,KIF7,MYOC,GLIS2,RHBDD2,DOCK8,ADCY1,TPP1,P2RY12,PSAP,ARHGDIA,BMPER,SGCD,UQCRQ,SLC7A11,ACO2,HSPA5,BIN1,CYBB,CCT5,MTMR2,LPIN2,RAD51C,CHMP1A,HK1,NAGA,PSMB5,TRIOBP,SGCG,HDAC2,PTPRQ,PEX7,XYLT1,CDK6,EIF2B3,RAPGEF3,FIG4,PGAP3,ARSA,OSTM1,CD3G,BCL2L1,CLCN7,HOGA1,LFNG,IRF8,MEGF8,ALG14,B3GALT6,RBBP8,NHP2,UGCG,CFTR,FAS,HMOX1,SLC19A3,HINT1,COL6A1,PARK7,STUB1,FLNA,PHYH,OGDH,ALPL,LONP1,ATP13A2,PSAT1,CALR,METTL23,RARS2,SPG21,HPS1,F13A1,TRIM2,SOD1,HSPD1,MRPS16,STT3A,RBCK1,MT-ND5,POLR3B,YARS2,SLC33A1,PSMD2,SLC16A1,CYC1,TBC1D7,MPV17,MMP9	163	
Cell Death and Survival	apoptosis	apoptosis of neurons	1.36E-06	 	-0.799	 	1.170	NPM1,MAP1B,UNC5B,CXCL12,HRAS,SH3GLB1,HSPA5,PANX1,NR2F1,SGPL1,LGMN,LYNX1,ATF4,GCLM,GSK3B,UNG,STXBP1,YWHAB,CNR1,SURF1,RAPGEF3,CITED1,SMPD2,HAX1,BCL2L1,DNAJC5,NR1D1,ADCYAP1R1,CDC42,DUSP1,MAPT,XRCC6,BTG2,PRKACA,MAPK10,CTSB,GAPDH,MAP2K3,AARS,ADCYAP1,ESR2,APOE,LEP,DDIT3,GSTM5,BAG6,HYOU1,PCDHGB4,HIF1A,FAS,HMOX1,HSP90AB1,PARK7,KCNMA1,TGFB2,EGLN3,NSMF,RPS3,FAM162A,NFE2L2,PLAT,PRNP,SIGMAR1,UCP2,TP63,TNFRSF1A,HSPH1,EGR1,NQO1,MAP3K1,TRIM2,SOD1,HSPD1,CEBPB,CPEB4,APP,SERPINE2,FOS,NTRK3,PPT1,PEA15,CYCS,MMP9	83	
Post-Translational Modification	glycosylation	glycosylation of protein	1.37E-06	 	0.415	 	-0.063	DAD1,RPN2,DPM1,DPM2,ST6GALNAC4,SLC35C1,HSPA5,OGT,FUOM,ENTPD5,MGAT4B,KRTCAP2,ALG8,SERPINA1,DPM3,MGAT1,NFE2L2,RPN1,STT3B,CALR,GCNT2,NQO1,ST3GAL6,MGAT5,ST6GALNAC3,GALNT13,POMGNT1,STT3A,ATXN10,B3GNT5,GXYLT2	31	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive system cancer	digestive system cancer	1.41E-06	 	-0.698	 	-0.174	PCLO,ASS1,GARS,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,GORASP2,VIT,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,DDIT3,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,AMOT,MTSS1L,RNF157,IPO7,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,DERL1,NR4A1,RPL37,BTBD2,EEF1A1,PIGU,AKR1C3,EML4,DNAJC15,CBX5,LHFPL2,STRN4,STC2,ABCB11,SNRPD1,TUBA1C,MTMR2,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,NHP2,PKHD1L1,RPL7A,COL6A1,F8,GID4,C16orf59,IGSF8,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,SOD1,SAA2,UTY,CFAP97,VAT1,TBL1Y,TXNDC12,FECH,MAP4K4,RPLP0,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,C9orf91,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,NINJ1,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,SDC3,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,GJB2,LIMCH1,RPS24,CD209,NAP1L4,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,FAM127B,SLC27A4,CHTOP,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,GOT1,AAGAB,COL27A1,FST,ACP2,POLR1A,PSMF1,CLTC,ANKMY2,IRX6,MAGED2,FAM45A,SLC4A7,RPL12,ATP10A,SLC39A3,GALNT13,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,SZRD1,CEBPB,SYNPO2,ANO2,EMP1,PLCB4,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,RAB38,SPTB,PLEKHO2,STAM,MGAT1,GNG12,MRPL24,ALDH1B1,PLD3,ICT1,MFAP5,CNR1,DCTD,SMOC2,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,APOE,NME1,PLXNA3,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,ARFGAP1,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,S100A1,SIGMAR1,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,PSAP,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ID4,ADRA1A,BZW2,NCDN,TPPP3,MEGF9,TMEM8A,SLC41A3,PPFIBP2,ACO2,BAG3,NME2,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,ARSA,TRIM35,TLN2,ADAM12,MATN2,XRCC6,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,MECR,AUP1,SLC38A1,LBHD1,VPS4A,IRAK1,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,KDM5D,SLC33A1,PSMD2,TBC1D7,CHI3L1,PMVK,MAF,PCDH7,SH3GLB1,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,CTSS,ABCC1,RPS2,TMEM9B,RIMS3,ZNF592,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,YARS,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,CDK16,CTNNA1,ACSF2,PFKL,SP2,MACC1,DCLK2,LIPA,SRGAP1,TBC1D12,PRKCE,NACC1,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,FTL,COL5A3,CLDN5,DOCK8,UQCR10,P2RY12,RUFY3,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,DYNLT1,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,MRPL43,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,GPS2,ANLN,MACROD1,ERH,PSMC4,UQCR11,MARS,RPL9,UBE2D2,PLEKHH2,IL1RN,HSPA13,STXBP5,PHF1,RNPEP,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,HSD11B2,RBM18,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,MKNK2,CSF1R,ARHGEF10L,ENO1,TNFAIP8L2,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,RPE,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,YWHAG,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,FCGR2A,PTRH1,SLC25A1,SPATS2L,PVR,CSTB,RNF6,MYO5A,CSF1,SEPHS1,SOX9,C1orf123,SDF4,SOCS3,PCDH18,SEPT9,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,TSEN15,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,C12orf49,NAGA,STXBP1,C2orf83,SESN3,HDAC2,STK39,UROS,CBX6,ASNA1,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,IGFBP4,DDX21,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,MT-CO1,PATL1,TP63,TRIM55,IPO4,TRIM2,TSN,WIPF3,POLR3B,C7orf43,CPAMD8,THEMIS2,HOXA6,ARPC5,RAN,GHITM,GYG2,MKI67,GSS,EXPH5,BBS1,RAD23A,AHSA1,LGMN,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,TSR3,NGRN,FARSA,INPP4B,FNDC1,RTN4,ME2,B3GNT5,SETBP1,GSTP1,BTG3,PPP1R3C,TMEM11,TTLL4,HYOU1,GPC4,EAF1,SDCCAG3,CDH11,ENAH,LYZ,CES1,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,SLC30A1,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,TIAL1,CASK,LRRC8D,SNTG2,CLIC6,HIST1H1E,SLC48A1,GLIS2,BRINP2,RHBDD2,SREBF1,TREM2,USP22,NAB2,PLCB2,PFN1,GTF3C6,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,TCEB2,CD63,GSPT1,CAMK2D,SLC25A6,PABPC4,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,MDH2,BCKDK,DSP,PCNXL2,C7orf50,MFSD3,HK1,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,RARRES3,NUAK1,CD14,CLCN7,LFNG,TBC1D16,DNPEP,ARL2,SPIRE1,SRM,SH3RF3,CNRIP1,TOLLIP,RAB1A,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,MAPKAPK2,KCTD1,OGDH,SHANK2,ATP5I,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,MAP3K1,RNF43,R3HDM1,OAF,VSIG4,MRPS16,PLXND1,KIAA1683,P4HA1,PLBD2,RPS4Y1,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,UNG,LCP1,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,XIST,HSPA2,SPTLC3,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,TSC22D2,TTYH3,ABCC3,C11orf68,CSTF3,SIGLEC6,PTER,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,RHOG,MEGF6,ENTPD5,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,BCAS2,C20orf27,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,NDUFA6,SLC25A39,CDH20,LIMA1,IGFBP3,CAPN2,MRPS2,PIK3AP1,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,REXO2,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,SAA1,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,PSAT1,CAPZB,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NDUFV3,NQO1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,EMC3,IVD,GXYLT2,FHL5,CADM3,SLC29A4,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,SH3BGRL3,MARK1,HRAS,NCSTN,CECR1,DGCR6L,PEG10,GAA,TXN,ANAPC11,WNT5B,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,PSMD14,TPO,ZNF70,AMFR,COX4I1,MYH1,DNAH12,LETM1,ADRM1,DTX4,TYROBP,IMPDH2,ACTB,FGD6,WDR12,CYP1B1,COPG1,AREL1,APP,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,TAF10,SDC4,TUBB,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,RAD51C,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,RPL13A,CEACAM21,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,EVC,TACR1,SEPHS2,SOX17,HMOX1,CCDC88A,NLK,PCK2,CSPG4,KCNMA1,NDUFC2,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,CYP27A1,COPS7A,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,LPAR1,DIP2C,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1289	
DNA Replication, Recombination, and Repair	degradation	degradation of DNA fragment	1.44E-06	 	1.898	 	1.174	LEP,UBQLN1,PAM16,CNR1,SOD1,REXO2,TPSAB1/TPSB2,FAS,APP,ENO1,BCL2L1,KEAP1,MAPT,RTN4,CAPN2,SERPINA1,NACC1,GSK3B	18	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	rheumatoid arthritis	rheumatoid arthritis	1.49E-06	 	0.108	 	-0.203	C9orf72,MMEL1,CTSG,C1QA,CLSTN2,MNAT1,EEF1G,PTPRC,DYNLL1,IP6K3,LTF,CHCHD2,TXN,AIF1,LCP1,CALCRL,NR1H3,HSPA8,TMEM127,CD68,CNTNAP4,IL10RA,MS4A7,CTSB,TFRC,GLUL,ALDOA,C3AR1,FTH1,SORL1,APOE,HLA-A,PRDX1,BAG6,ADIPOQ,HSPB8,FKBP1A,ST6GALNAC4,GPC4,SDC3,CDH11,LYZ,TNXB,ALPK2,FKBP5,RPL31,MYL12A,RPS24,TNFRSF1A,FCGR2A,TRIM28,SPATS2L,GRN,FOS,ITGB2,RPS16,CSF1,NR4A1,TSPO,SOCS3,SLC7A11,ARF1,CD4,PRMT3,CXCL12,SDC4,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,RPL32,SPP1,DNASE2,HDAC2,LMO4,ERH,RAB10,CDK6,PPP1R11,FOSB,SEL1L,DUSP1,IL1RN,SLC7A2,NAGLU,PPAT,RPSA,IGFBP4,PRDX5,SLC7A1,CD83,NELFE,EVC,HLA-G,HMOX1,SLFN5,RPL18A,CCSER2,THBS1,ANXA1,SAA1,EFNB1,TGFB2,RPS3,ALPL,PRNP,CALR,VCAM1,VSIG4,HSPD1,CEBPB,ATIC,FAU,CXCL16,ENO1,APLP2,DIP2C,CHI3L1,MAP4K4,MMP9	124	
Cellular Growth and Proliferation	colony formation	colony formation of cells	1.73E-06	Increased	2.259	 	1.373	ICMT,NPM1,TRAF3,VPS28,CD4,RACK1,NME2,CXCL12,HRAS,EIF6,GPC3,BIN1,SPRY4,CTSD,HOXA10,NUPR1,ANXA7,C1QBP,RET,PTX3,BIRC7,SPP1,PTP4A3,CLTC,HSPA9,FGFR2,TPM3,THRA,JUNB,HMGA1,KLF4,NDN,SLC3A2,SEL1L,BCL2L1,CDC42,IL1RN,LIMA1,CTSB,IGFBP3,SFRP1,IRF8,SQSTM1,CYR61,ESR2,ALK,IGFBP4,ADAM17,RALA,LEP,SFRP2,DDIT3,EPB41L3,MMP14,ADIPOQ,LEO1,RUVBL1,HIF1A,FAS,HMOX1,SHC1,PSMD10,PHB,ANXA1,MCAM,ERBB4,TGFB2,KIT,RHOBTB2,SELENOH,SERPINA1,SEMA3B,S100A1,RPS19,TP63,MECOM,EGR1,MAP3K1,DVL1,LZTS2,SOD1,MKNK2,CSF1R,ATIC,GRN,FOS,ENO1,NTRK3,CSF1,PEA15,PLAU,ID4,MMP9	93	
Cellular Development, Tissue Development	differentiation	differentiation of connective tissue	1.78E-06	 	1.250	 	0.060	CTGF,MAF,HRAS,SLC9A1,RPS11,GPR55,POR,PTPRC,DYNLL1,PEG10,LTF,ATF4,ZBTB16,WNT5B,SLC2A5,FGFR2,JUNB,BCAP29,INPP4B,NR1D1,PRKACA,TFRC,MAP2K3,LRP8,SFRP1,SQSTM1,CYR61,C3AR1,APOE,TCEA1,DDIT3,SLC1A5,BAG6,LRP6,ADIPOQ,LGALS9,GPC4,ATRAID,ATP6AP1,SMARCA4,MAFG,PHB,SNX10,OSBPL11,PRKCE,LY6E,RPS19,MECOM,TYROBP,TRIB3,APP,GRN,MRAP,FOS,MYOC,CCDC85B,SREBF1,CSF1,TREM2,FCER1G,NR4A1,BMPER,SOX9,PLAU,BMP6,ID4,GAB2,SOCS3,RACK1,GPC3,NR2F1,CTBP1,HOXA10,GSK3B,EIF2AK1,SPP1,DNASE2,FSTL3,PTPRQ,CLTC,ERH,CDK6,RAPGEF3,THRA,CITED1,KLF4,OSTM1,BCL2L1,SIRPA,CREBL2,PTGFR,ANGPTL8,DDX21,SCD,SFRP2,LEP,ATF5,MMP14,HIF1A,FAS,TNFRSF12A,HMOX1,NLK,COL6A1,EFNB1,HSPE1,TGFB2,KIT,EGLN3,HCST,IARS,ALPL,TP63,GABBR1,ZBTB7C,SOD1,CEBPB,TMEM14C,CSF1R,NFE2L1,FGF1,EMP1,RPS15,CAPNS1,LPAR1,NUCB2,FECH,NCKAP1L,SCAND1,MMP9,CARM1	131	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of tumor cells	1.86E-06	Increased	2.639	 	1.343	EEF1A1,ICMT,SOCS3,NPM1,CA12,CXCL12,HRAS,DIRAS1,MKI67,HSPA5,GPC3,ODC1,PEG10,SAE1,PLCE1,CCND3,CTSS,HOXA7,GSK3B,GPC1,RET,AHCY,PFKFB3,SPP1,FST,HDAC2,LAIR1,CDK6,ANXA2,SLC3A2,PYGO2,BCL2L1,ADCYAP1R1,BSG,IL1RN,DUSP1,BTG2,CTSB,IGFBP3,SFRP1,SQSTM1,CYR61,AKR1B1,ESR2,ALK,CD151,LITAF,FHL1,LEP,SFRP2,DDIT3,MMP14,GDF15,ADIPOQ,PROX1,RUVBL1,HIF1A,TAX1BP3,FAS,NELFE,UCHL1,HMOX1,PARK7,THBS1,ANXA1,MCAM,FBXW11,TGFB2,KIT,RHOBTB2,PRKCE,SEMA3B,ACVR1C,PLAT,NDUFAF3,COX17,TP63,EGR1,LZTS2,CSF1R,FGF1,GRN,FOS,TNFAIP8L2,CSF1,NR4A1,PLAU,MMP9	88	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of antigen presenting cells	1.97E-06	 	0.927	bias	-1.425	NAB2,NPM1,CTGF,PLP1,PFN1,CTSG,CXCL12,HRAS,NARS,ABCC1,CXCL14,ITGAV,CYBB,STAB1,PTX3,SPP1,CNR1,CNP,NINJ1,IL1RN,SH2B3,IL10RA,ALCAM,PLTP,CYR61,C3AR1,SIRPA,RPL13A,APOE,ADAM17,LITAF,LEP,NQO2,ADIPOQ,HIF1A,G6PC3,HMOX1,CCDC88A,CES1,GBA,THBS1,FLNA,ANXA1,DUSP10,SAA1,KIT,EGLN3,MAPKAPK2,NFE2L2,IL11RA,PRNP,SEMA3E,RPS19,CD209,EDNRB,TYROBP,NQO1,PLXND1,CSF1R,APP,ITGB2,TNFAIP8L2,GLIS2,CSF1,DOCK8,SREBF1,TREM2,PLAU,C6	69	
Dermatological Diseases and Conditions, Immunological Disease, Inflammatory Disease	lichen planus	lichen planus	2.03E-06	 	 	 	 	RNPEPL1,IGFBP6,APOE,EEF1A1,LCP1,ATP5G1,PFN1,LAPTM5,CFL1,SYNGR2,HLA-A,FKBP1A,FOLR2,TYMP,PLXND1,CD52,GRN,ENO1,DYNLL1,VKORC1,ABCC1,FASTK,IFI30,EIF5A,FTH1	25	
Organismal Survival	survival	survival of organism	2.04E-06	 	0.258	bias	-2.148	NPM1,CTGF,PCLO,HRAS,MKI67,ODC1,PTPRC,GORASP2,ABCC1,KEAP1,GNA13,MGAT1,ARRDC4,PPP1R1B,CNR1,PTP4A3,JUNB,CCND2,STIP1,PRKACA,CTSB,GLUL,DUSP4,PLTP,B3GNT5,ADCYAP1,ESR2,C3AR1,GSTP1,ALK,APOE,NME1,HTATIP2,NQO2,HYOU1,LGALS9,SMARCA4,LYZ,ARF6,PHB,TOP2A,NFE2L2,PLAT,S100A1,UCP2,PPIF,TNFRSF1A,FCGR2A,GNA12,SNCG,APP,FOS,MARCKSL1,FTL,NTRK3,SREBF1,CSF1,TREM2,USP22,PEA15,CYCS,ARHGDIA,GABARAP,SGCD,NCAM1,SOCS3,SLC31A1,SESN2,CD4,CXCL12,CD28,CYBB,HOXA7,SIAH2,GSK3B,RET,NSMAF,DSP,PTX3,FST,SPP1,SESN3,CDK6,EIF4E2,BCL2L1,DNAJC5,ADRA2A,DUSP1,IL1RN,MAPT,ALDH1A2,CD14,NUAK1,LFNG,IRF8,STXBP5,TFPI,RPL13A,LITAF,LEP,F2RL3,MMP14,PKM,CFTR,VPS4A,MLH1,FAS,IRAK1,HMOX1,SHC1,THBS1,ANXA1,ERBB4,GSTM4,KIT,EGLN3,MAPKAPK2,HSPB6,PRNP,CALR,COL5A2,TP63,SOD1,CEBPB,TNFAIP8L2,LPAR1,SLC33A1,ADAM9,MMP9	129	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	cold thyroid nodule	benign cold thyroid nodule	2.08E-06	 	 	 	 	CALR,HSP90AB1,PARK7,PRDX5,ANXA5,CTSB,TPO,GSTP1,APP	9	
Lipid Metabolism, Small Molecule Biochemistry	storage	storage of triacylglycerol	2.08E-06	 	1.316	bias	0.427	SCD,APOE,LIPA,PLIN1,LEP,PLIN2,SURF1,DGAT2,OSBPL11	9	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	invasion	invasion of tumor	2.09E-06	Increased	4.297	bias	2.450	GAB2,TRAF3,CTGF,CXCL12,HRAS,TYMP,HSPA5,RHOG,CTSS,GPC1,ZBTB16,DSP,AHCY,BIRC7,SPP1,ANXA2,KLF4,BSG,CTSB,CD14,ALCAM,CAPN2,SFRP1,ALK,CD151,APOE,NME1,LEP,MMP14,GDF15,ADIPOQ,FKBP1A,PROX1,HIF1A,FAS,HMOX1,PSMD10,PARK7,FLNA,THBS1,MCAM,RHOBTB2,NFE2L2,CD53,GNA12,HYAL1,CSF1,PLAU,ADAM9,MMP9	50	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of antigen presenting cells	2.19E-06	 	1.296	bias	-0.724	TRAF3,CD4,MAF,STARD7,LTF,CTSS,ITGAV,CYBB,RAB10,NR1H3,RAPGEF3,ANXA2,KLF4,OSTM1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,MAP2K3,SIRPA,ABHD12,APOE,RAB32,RAB4A,LEP,TOLLIP,MSR1,DDIT3,HLA-A,ADIPOQ,HSPB8,LGALS9,FAS,IRAK1,TNFRSF12A,HMOX1,THBS1,DUSP10,PRKCE,TPO,PLAT,PRNP,CD209,CALR,TYROBP,TNFRSF1A,FCGR2A,AP3D1,SOD1,HSPD1,CEBPB,CSF1R,APP,PSME1,TNFAIP8L2,CSF1,TREM2,PPT1,FCER1G,C6,CHI3L1,MMP9	63	
Cancer, Organismal Injury and Abnormalities	adenoma	adenoma	2.32E-06	 	-0.049	bias	1.277	ASS1,CA12,HRAS,ODC1,ZBTB7B,CCND3,KEAP1,UNG,ALDOC,MFAP5,CNR1,DKC1,TUBB2A,FGFR2,ANXA2,PCK1,HMGA1,NDN,PLAG1,MRPL17,CTSB,PRKACA,GLUL,ARHGAP35,LRP8,ESR2,GSTP1,SLC4A4,APOE,S100A11,HTATIP2,GSTM5,PRDX1,PAM16,HN1,ARL4C,ADIPOQ,RUVBL1,COL15A1,HSP90AB1,ANXA5,DAB2,TPO,CCDC68,MECOM,EGR1,DGAT2,TRIB3,CYP1B1,FOS,ATP6V1F,SLC48A1,PRMT5,NR5A2,SOX9,ID4,KCND3,NTMT1,RNASE1,CES2,ENTPD5,SLC7A5,GSK3B,SPP1,TBC1D2B,BCL2L1,PPP2R1A,ALDH1A2,TMEM176B,UBE2I,IGFBP4,LEP,EPB41L3,SCARA5,MMP14,PKM,MLH1,HMOX1,HINT1,PARK7,THBS1,MCAM,HSD11B2,KIT,ARHGEF2,ASAP3,CALR,PSAT1,VCAM1,TP63,MAP3K1,MGAT5,VSIG4,C2orf88,LPAR1,SLC33A1,PAG1,EPHB3,CLDN2,MMP9	100	
Nucleic Acid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of nucleotide	2.38E-06	Increased	2.276	bias	0.314	SOCS3,ATP5D,DPM1,RRM2B,COX8A,NME2,ATP5L,HRAS,TYMP,SLC27A4,GNB1,NNMT,AK1,PGD,G0S2,UQCC2,ENTPD5,NDUFS6,GNA13,MDH2,CALCRL,SPP1,CNR1,TALDO1,SURF1,CTPS1,OLA1,HSPA8,ADCYAP1R1,ADRA2A,MAPT,GPR65,ADM2,ALDOA,VDAC1,ADCYAP1,PPAT,RPSA,APOE,ATP5G1,RAB4A,ATP5H,LEP,CHCHD10,PKM,CFTR,HIF1A,ME1,FAS,REXO2,HMOX1,SHC1,THBS1,DCXR,ATP5J2,OGDH,LONP1,SLC25A13,OAS1,ADCY2,MT-ATP6,UCP2,LETM1,PPIF,USMG5,IMPDH2,NQO1,GABBR1,SOD1,HSPD1,GUK1,CEBPB,APP,MRAP,LPAR1,ADCY1,PANK3,NUCB2,P2RY12,CYCS,SLC25A5,BMP6	82	
Molecular Transport	transport	transport of heavy metal	2.57E-06	 	-0.412	 	-0.601	SLC31A1,ARF1,SCARA5,HLA-A,CD4,HIF1A,FAS,HMOX1,SLC39A1,LTF,NEO1,SLC30A1,NFE2L2,PRNP,EIF2AK1,AP3D1,SLC39A6,SOD1,SLC39A3,APP,CISD1,FTL,APLP2,MAPT,FKBP4,TFRC,FECH,BMPER,ATOX1,BMP6,STEAP3,FTH1	32	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial myopathy	mitochondrial myopathy	2.62E-06	 	 	 	 	MT-CO1,MT-ATP6,MT-TY,RRM2B,SURF1,MT-TC,TYMP,NDUFA2,SCO2,MT-ND5,MT-ND1,YARS2,NDUFS8,MT-CYB,RMND1,NDUFA12,MPV17,NDUFS4,MT-TP	19	
Cell-To-Cell Signaling and Interaction	aggregation	aggregation of cells	2.67E-06	 	1.239	bias	-0.671	RAP2B,PSG2,PLCB2,SLC7A11,CD4,CXCL12,CTSG,CD63,PTPRC,RHOG,LTF,ITGAV,ANXA7,GSK3B,GNA13,RET,FERMT3,PTX3,STXBP1,CITED1,SLC3A2,MYL9,BSG,ADRA2A,PLEK,AKR1B1,ACTG1,SIRPA,CD151,LEP,F2RL3,FIBP,MMP14,GDF15,ADIPOQ,HIF1A,SDK1,CDH11,SHC1,LYZ,CES1,PHB,FLNA,THBS1,KIT,DAB2,IGSF8,AMOT,MYL12A,PLAT,CD209,VCAM1,TNFRSF1A,FCGR2A,ACTB,GNA12,SOD1,NFASC,APP,SERPINE2,ITGB2,FCER1G,P2RY12,MMP9,NCAM1	65	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	infiltration by neutrophils	2.71E-06	 	-0.692	 	-1.472	APOE,SOCS3,PLCB2,ADAM17,CTGF,PLP1,NQO2,UNC5B,CTSG,ADIPOQ,CFTR,FAS,TACR1,HMOX1,ANXA1,SERPINA1,STIM1,GJB2,PLAT,PTX3,SPP1,TNFRSF1A,NQO1,HYAL1,ALOX5AP,ITGB2,EDIL3,TNFAIP8L2,IL1RN,CSF1,DUSP1,FCER1G,CTSB,CD14,SFRP1,PLTP,C3AR1,MMP9	38	
Neurological Disease	neurodegeneration	neurodegeneration of central nervous system	2.92E-06	Decreased	-2.300	bias	-0.307	ADIPOQ,VAC14,GBA,GLB1,STUB1,CYBB,GSK3B,CLCN3,UNG,PRNP,PLAT,NDUFS4,CNR1,CNP,SOD1,ARSA,NFE2L1,APP,SH3GL1,BCL2L1,MAPT,PPT1,CTSB,PSAP,NAGLU,TPP1,CLCN7,SQSTM1	28	
Cellular Development	differentiation	differentiation of tumor cell lines	2.93E-06	 	0.914	 	-0.818	NAB2,NPM1,SOCS3,CTGF,PRPF19,AKR1C3,CTSG,HRAS,ODC1,SPRY4,NR2F1,SGPL1,ALPK3,KEAP1,HOXA10,ATF4,GSK3B,C1QBP,RET,ZBTB16,FST,STK39,CDK6,FGFR2,RAPGEF3,CREG1,ANXA2,THRA,KLF4,NDN,BCL2L1,CDC42,DUSP1,IL1RN,BTG2,CD14,CYR61,ADCYAP1,SIRPA,ETV5,ALK,NME1,RPS3A,DDIT3,NID2,PPIA,AUP1,HIF1A,SMARCA4,CDH11,HMOX1,SHC1,SRGAP1,ERBB4,TRIM16,KIT,DAB2,PRKCE,STIM1,NFE2L2,ACVR1C,PLAT,CALR,TP63,TNFRSF1A,EGR1,CEBPB,APP,FOS,ENO1,CSF1,ADRA1A,NCAM1	73	
Organismal Development	morphology	morphology of body cavity	2.98E-06	 	 	 	 	RRM2B,SLC35C1,POR,PTPRC,CCND3,PLIN5,ATF4,GNA13,UNG,FGFR2,DES,PYGO2,CTSA,ATMIN,ESR2,STEAP3,APOE,SLC4A2,PRDX1,BAG6,GDF15,HS2ST1,ADIPOQ,HSPB8,HEXA,SDK1,ARF6,DAB2,LY6E,GNG5,NFE2L2,MECOM,TNFRSF1A,SLC6A6,LZTS2,GRN,MARCKSL1,FOS,NTRK3,CSF1,PPT1,PSAP,ARHGDIA,BMPER,SOX9,SGCD,SOCS3,DAD1,GPC3,NPC1L1,BIN1,CEBPG,CD28,HS6ST1,CTSD,ENTPD5,HOXA10,NUPR1,HOXA7,ABCB11,HDAC2,FSTL3,MAPK8IP2,RAPGEF3,THRA,KLF4,BCL2L1,ADAM12,DUSP1,XRCC6,ALDH1A2,IGFBP3,NAGLU,CAPN2,H1F0,IRF8,MEGF8,TNS1,RPSA,CD151,IGFBP4,RAB4A,SRPX,MSR1,PYCARD,MLH1,SLC19A3,SHC1,RAD23B,LASP1,SLC20A1,VCAM1,CAPZB,TP63,TRIM55,EDNRB,NPY1R,NQO1,EMD,SOD1,KIF3B,NFE2L1,NR6A1,APOB,CTGF,PLIN1,ITGA8,NCSTN,KPNA1,APRT,LGMN,GAA,CALCRL,CENPB,NR1H3,TSPAN33,PCK1,HMGA1,JUNB,CCND2,BSG,ARHGAP35,MAP2K3,B3GNT5,C3AR1,SLC4A4,ADAM17,LRP6,FKBP1A,CDH11,LIPA,CES1,GBA,PRKCE,SMPD3,EGR1,TIAL1,COPS3,APP,ITGB2,LAMP2,GLIS2,SREBF2,LIMS1,BMF,FKBP4,FCER1G,NR5A2,DVL3,PLAU,CD4,SDC4,SLC27A4,PLCE1,COMT,ITGAV,CYBB,ANXA7,GSK3B,CLCN3,RET,KLF2,EIF2AK1,PTX3,SPP1,DNASE2,SGCG,PHB2,CDK6,TIE1,IL1RN,SH2B3,LFNG,AKR1B1,TMOD1,LEP,PDGFA,MMP14,UGCG,CFTR,HIF1A,FAS,HMOX1,FLNA,THBS1,ERBB4,TGFB2,HSD11B2,EGLN3,HCST,ALPL,CALR,MAP3K1,HYAL1,CEBPB,NFKBIZ,PLXND1,CSF1R,TNFAIP8L2,ITPA,GBE1,EPHB3,CPEB1,ADAM9,MMP9,CARM1	206	
Cell Death and Survival	cell death	cell death of colorectal cancer cell lines	2.98E-06	 	-1.482	 	-1.345	PSG2,TRAF3,VPS28,COX8A,BAG3,HRAS,CTBP1,G0S2,AHSA1,CSE1L,ITGAV,GSK3B,TMSB10/TMSB4X,BIRC7,SPP1,HDAC2,PPP1R1B,CNR1,TXNRD1,BCL2L1,CDC42,ATMIN,IGFBP3,NUAK1,CAPN2,SQSTM1,IRF8,PHF1,VDAC1,GSTP1,PHLPP1,ADAM17,LEP,DDIT3,PYCARD,BTG3,DAPK2,GDF15,PKM,PPIA,MLH1,FAS,HMOX1,RABL6,HINT1,NAA38,PARK7,HCST,LONP1,NFE2L2,TNFRSF1A,HSPD1,NTRK3,LIMS1,USP22,CYCS,SOX9	57	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial encephalomyopathy	mitochondrial encephalomyopathy	2.98E-06	 	 	 	 	MT-ATP6,MT-TY,RRM2B,SURF1,MT-TC,TYMP,NDUFA2,SCO2,MT-ND5,MT-ND1,NDUFS8,MT-CYB,RMND1,NDUFA12,MPV17,NDUFS4,MT-TP	17	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of glycolipid	3.27E-06	Increased	2.360	bias	0.511	SCD,LEP,PIGU,DPM1,DPM2,ADIPOQ,UGCG,ST6GALNAC4,HEXA,FAS,CERS2,SGPL1,GBA,GLB1,ABCC1,KIT,DPM3,NSMAF,CLN6,SMPD3,GM2A,ST3GAL6,ST6GALNAC3,ARSA,SMPD2,GPAA1,DEGS1,APP,BCL2L1,MPDU1,MAPK10,PSAP,B3GNT5,ADCYAP1	34	
Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis	3.35E-06	Increased	4.297	bias	1.447	NPM1,GAB2,PFN1,CD4,RACK1,SH3GLB1,C1QA,BIN1,CLIP1,PTPRC,RHOG,ABR,MCOLN3,ITGAV,CYBB,CLCN3,KLF2,GULP1,EIF2AK1,PTX3,CLTC,RAPGEF3,CAPG,HSPA8,OSTM1,CDC42,CD14,IRF8,SIRPA,RALA,LEP,MSR1,PYCARD,ADIPOQ,FAS,HMOX1,ARF6,KCNMA1,THBS1,ANXA1,ANXA5,SAA1,PRKCE,TUB,STIM1,MAPKAPK2,CALR,UCP2,FCGR2A,RAB7A,CEBPB,APP,MYO5A,ITGB2,LAMP2,CSF1,TREM2,FCER1G,ASAP2,PLAU	60	
Cell Death and Survival	cell death	cell death of endothelial cells	3.49E-06	 	-0.028	 	0.009	ICMT,ADAM17,LEP,DDIT3,PSMB10,ASS1,DUSP6,ADIPOQ,CXCL12,PPIA,HRAS,TYMP,HSPA5,FAS,LIPA,HMOX1,THBS1,MCAM,PRKCE,SERPINA1,TXN,GSK3B,SEMA3B,MAPKAPK2,KLF2,NFE2L2,PLAT,SPP1,UCP2,TNFRSF1A,CNP,DGKE,HSPD1,FGF1,APP,BCL2L1,EDIL3,PRKACA,IGFBP3,CYCS,MAP2K3,VDAC1,MMP9	43	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	muscle tumor	muscle tumor	3.52E-06	 	 	 	 	TWF1,RPE,ASS1,TMEM184B,GPR55,PTPRC,LTF,PLEKHO2,SLC2A5,ALDH1B1,PLD3,CNR1,FGFR2,RPH3A,CYP4B1,ESR2,TRAPPC5,FTH1,APOE,SLC4A2,PHLDA2,BAG6,GDF15,SEC23B,ZDHHC11B,TECR,HSP90AB1,SORBS1,SERPINA1,RPN1,TUBB4B,ALOX5AP,THAP11,FOS,MYOC,DOPEY2,NR4A1,ADRA1A,SOCS3,MEGF9,AKR1C3,SCN7A,MRPL47,BAG3,MRVI1,CTSD,HS6ST1,TMEM132C,MEGF6,CXCL14,ERAL1,TUBA1C,ADAMTS5,CNP,LAMA2,RAPGEF3,ARSA,TXNRD1,DMXL2,BCL2L1,KCNG1,ADAM12,ADRA2A,DUSP1,NDUFA6,TXN2,CCPG1,SCD,LITAF,MSR1,SCARA5,PKHD1L1,SHC1,RPL14,RAD23B,TP63,DCTN3,EDNRB,DVL1,TUBG1,PYGB,CXCL16,RPS15,SLC33A1,MUC17,FECH,MAP4K4,RAP2B,NR6A1,CPAMD8,APOB,AHCYL1,MAF,HRAS,MKI67,ABCC6,LGMN,CTSS,PXK,POU6F2,PNKD,MED16,WNT5B,CAPN6,CALCRL,SLC24A3,GSTM3,TUBB2A,KAZALD1,PCK1,HMGA1,AP2S1,ACAD11,RTN4,ME2,ALDOA,SFRP1,FH,CYR61,MYEOV,GSTP1,ALK,SORL1,ALDH4A1,S100A11,UQCRH,HYOU1,SDC3,PFKL,UCHL1,LIPA,IFRD2,SCN3A,TRIM16,TOP2A,ACVR1C,COX4I1,RPS19,TYROBP,STXBP6,CYP1B1,ITGB2,COL5A3,P2RY12,NR5A2,CBX4,CLUH,NCAM1,PNO1,PLP1,MYH15,MRPL54,MMRN1,NR2F1,CNDP2,DPP3,RPL19,RET,SPP1,ACP2,ATP10A,TPSAB1/TPSB2,UBXN11,RPL9,MAPT,SH2B3,CLCN7,CYP4A11,SLC7A1,UGCG,CFTR,FAS,CSPG4,PHYH,ERBB4,F5,MICALL1,KIT,ALPL,PRNP,FRMD1,DLGAP4,CENPV,HYAL1,GABBR1,ZBTB7C,SLC5A3,CSF1R,THRSP,ARHGEF10L,PLCB4,ITPA,NUCB2,GBE1,ADAM9,MMP9	196	
Infectious Diseases	replication	replication of RNA virus	3.54E-06	Increased	5.357	bias	2.734	EEF1A1,NPM1,SOCS3,PCDH18,AHCYL1,PRMT3,CD4,RABEP1,TXNL4A,CXCL12,HRAS,TUBB,MNAT1,PANX1,NR2F1,PTPRC,CTBP1,CD28,SGPL1,SAE1,DUSP3,CSE1L,HOXA7,ATF4,MID1IP1,STAB1,GSK3B,MGAT1,FERMT3,PTX3,SPP1,STK39,SNRPF,FGFR2,COPB1,ATP6V1A,NRBP1,BCL2L1,CDC42,FSCN1,ATP6V0D1,PRKACA,LSM1,RARRES3,MAP2K3,RPL13A,RPSA,ATP6V0C,ATP6V0B,MSR1,GBP1,DAPK2,PRDX1,LGALS9,PPIA,NAA10,DCLK1,EIF2S1,ATP6AP1,HMOX1,DCLK2,RPL35,HSP90AB1,ANXA5,TGFB2,SNX10,LY6E,PSMD14,SERPINA1,RPS5,LONP1,PRNP,SIGMAR1,CD209,AGFG1,OAS1,EXOSC5,RPS10,F13A1,HSPD1,STX10,FAU,COPG1,EIF3G,LAMP2,RPS16,PSMD2,PLAU,MAP4K4,ATP6V1B2,MMP9,CLUH	92	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of leukocytes	3.56E-06	 	1.943	 	-0.425	NPM1,APOB,MAF,HRAS,C1QA,SLC35C1,CHST2,PTPRC,ZBTB7B,SGPL1,LGMN,CCND3,CTSS,MGAT4B,ST6GALNAC2,STAM,GNA13,APEX2,ZBTB16,CALCRL,LAIR1,MFAP5,DKC1,FGFR2,NR1H3,TSPAN33,HAX1,IL10RA,B3GNT5,ADCYAP1,C3AR1,ESR2,GSTP1,SLC4A4,APOE,ADAM17,DDIT3,PSMB10,HLA-A,PRDX1,NQO2,GDF15,ADIPOQ,PPIA,SMARCA4,G6PC3,CES1,GBA,SORBS1,PRKCE,SERPINA1,NFE2L2,PLAT,TYROBP,TNFRSF1A,FCGR2A,IMPDH2,EGR1,GNA12,SLC6A6,APP,FOS,ITGB2,CSF1,DOCK8,SREBF1,TREM2,BMF,FCER1G,NR4A1,PSAP,ARHGDIA,PLAU,SOCS3,GAB2,TRAF3,PLP1,CD4,MBP,BAG3,CXCL12,STARD7,PAX5,CD28,CTSD,PLCE1,COMT,CXCL14,CYBB,STAB1,FERMT3,SPP1,DNASE2,LAMA2,GCNT2,CDK6,THRA,FYB,KLF4,PKN1,FOSB,BCL2L1,CD3G,ADAM12,IL1RN,DUSP1,SH2B3,XRCC6,MAPT,IGFBP3,PIK3AP1,IRF8,CYP4A11,SIRPA,LITAF,LEP,PYCARD,CD83,HIF1A,FAS,IRAK1,HLA-G,HMOX1,SHC1,HINT1,THBS1,DKK3,FLNA,EFNB1,DUSP10,SAA1,KIT,HCST,MAPKAPK2,ALPL,PRNP,SLC20A1,VCAM1,CYP27A1,NPY1R,NQO1,ST3GAL6,F13A1,VSIG4,SOD1,CEBPB,CSF1R,PSME3,IL20RB,CXCL16,TNFAIP8L2,SLC33A1,FASTK,PAG1,C6,CHI3L1,CARM1,MMP9	158	
Post-Translational Modification	phosphorylation	phosphorylation of protein	3.56E-06	Increased	2.114	bias	-0.563	CTGF,CTSG,MARK1,HRAS,MNAT1,ODC1,PTPRC,DYNLL1,IP6K3,SRPX2,CCND3,AIF1,CFL1,FLOT1,FGFR2,ANXA2,HSPA8,CCND2,BSG,FNDC1,PRKACA,ADM2,MAP2K3,B3GNT5,SQSTM1,CYR61,ALK,PHLPP1,NME1,ADAM17,DAPK2,PRDX1,DUSP6,CDK16,LRP6,ADIPOQ,PPIA,FKBP1A,OGT,AAK1,DAB2,PRKCE,CSNK2B,ACVR1C,NDUFS4,TYROBP,FCGR2A,TRIM28,HSPA2,APP,CALM1 (includes others),ITGB2,COL5A3,EDIL3,NTRK3,FAM129A,CSF1,FCER1G,PSAP,SOX9,DVL3,SOCS3,RGMA,SESN2,CD4,RACK1,NME2,CTBP1,CD28,HSPA4,CAMK2D,CDON,GSK3B,RET,BCKDK,EIF2AK1,HK1,SPP1,STK39,CDK6,RAPGEF3,FYB,CDK2AP1,PKN1,SLC3A2,ERP29,SDCBP,DUSP1,IGFBP3,MAPK10,NUAK1,UHMK1,PEBP1,LEP,TOLLIP,EIF2S1,FAS,IRAK1,CCDC88A,NLK,PARK7,THBS1,ERBB4,TGFB2,LOC102724428/SIK1,KIT,HCST,MAPKAPK2,GMFB,PRNP,CALR,EDNRB,DVL1,MAP3K1,MKNK2,CSF1R,FGF1,SHB,PAG1,FASTK,EPHB3,NCKAP1L,MAP4K4,MMP9	124	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function	activation	activation of blood cells	3.57E-06	Increased	2.189	bias	-0.553	RAP2B,MAF,CTSG,TIGIT,C1QA,PTPRC,ZBTB7B,DUSP3,LTF,CTSS,GNA13,LAIR1,CNR1,NR1H3,ANXA2,MAP2K3,SFRP1,ADCYAP1,C3AR1,ABHD12,APOE,RAB32,LAPTM5,DDIT3,HLA-A,HYOU1,ADIPOQ,HSPB8,LGALS9,PPIA,FKBP1A,SMARCA4,PRKCE,STIM1,TPO,NFE2L2,PLAT,CD209,TYROBP,TNFRSF1A,IMPDH2,FCGR2A,APP,GRN,FOS,ITGB2,PSME1,CSF1,TREM2,PPT1,FCER1G,P2RY12,TRAF3,RGMA,PLP1,CD4,MBP,CXCL12,STARD7,CD63,PAX5,CD28,HSPA4,ITGAV,CYBB,RET,KLF2,SPP1,RAB10,RAPGEF3,KLF4,TPSAB1/TPSB2,OSTM1,BCL2L1,CD3G,DUSP1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,PLEK,IRF8,SIRPA,RAB4A,LEP,TOLLIP,F2RL3,MSR1,PYCARD,PDGFA,KLRD1,CD83,HIF1A,FAS,IRAK1,TNFRSF12A,HLA-G,TACR1,HMOX1,SHC1,THBS1,ANXA1,DUSP10,SAA1,F5,KIT,PRNP,CALR,VCAM1,NPY1R,HSPH1,AP3D1,HPS1,MGAT5,SOD1,HSPD1,CEBPB,NFKBIZ,IL20RB,CSF1R,FGF1,SERPINE2,TNFAIP8L2,SLC33A1,PAG1,C6,CHI3L1,ADAM9,MMP9	130	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	necrosis	necrosis of kidney	3.60E-06	 	0.541	 	-0.390	GFPT1,CTGF,CCNI,UNC5B,HRAS,HSPA5,APRT,SGPL1,RHOG,CDON,MCOLN3,ABCC1,ITGAV,NEO1,GSK3B,GNA13,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,DUSP1,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,SFRP1,VDAC1,GSTP1,APOE,GSTM5,DDIT3,PYCARD,LRP6,HYOU1,HIF1A,FAS,HMOX1,STUB1,ERBB4,AAK1,NFE2L2,GMFB,ATP13A2,PLAT,PRNP,TMEM123,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,FGF1,APP,EMP1,FOS,MYOC,TNFAIP8L2,GLIS2,NTRK3,SREBF2,CSF1,PEA15,CYCS,PLAU,SLC47A1	70	
Cell-To-Cell Signaling and Interaction	binding	binding of leukemia cell lines	3.93E-06	 	1.597	bias	0.232	FERMT3,SIGMAR1,CD209,VCAM1,HLA-A,CXCL12,ANXA2,FAS,APP,ITGB2,CD68,DOCK8,CSF1,ANXA5,ITGAV,CD14,PLAU	17	
Cellular Development, Tissue Development	differentiation	differentiation of connective tissue cells	3.99E-06	 	0.568	 	-0.402	CTGF,MAF,SLC9A1,RPS11,GPR55,POR,DYNLL1,PEG10,LTF,ATF4,ZBTB16,WNT5B,SLC2A5,FGFR2,JUNB,BCAP29,INPP4B,NR1D1,PRKACA,TFRC,LRP8,MAP2K3,SFRP1,SQSTM1,CYR61,C3AR1,APOE,DDIT3,SLC1A5,BAG6,LRP6,ADIPOQ,LGALS9,GPC4,ATRAID,ATP6AP1,SMARCA4,MAFG,PHB,OSBPL11,SNX10,PRKCE,LY6E,MECOM,TYROBP,TRIB3,MRAP,GRN,FOS,MYOC,CCDC85B,SREBF1,CSF1,TREM2,NR4A1,FCER1G,BMPER,SOX9,PLAU,BMP6,ID4,GAB2,SOCS3,RACK1,GPC3,CTBP1,NR2F1,HOXA10,GSK3B,SPP1,FSTL3,PTPRQ,CLTC,ERH,CDK6,RAPGEF3,CITED1,KLF4,OSTM1,SIRPA,CREBL2,ANGPTL8,DDX21,SCD,PTGFR,SFRP2,LEP,ATF5,MMP14,HIF1A,FAS,HMOX1,COL6A1,NLK,EFNB1,HSPE1,TGFB2,EGLN3,HCST,IARS,ALPL,TP63,GABBR1,ZBTB7C,SOD1,CEBPB,CSF1R,NFE2L1,FGF1,RPS15,CAPNS1,LPAR1,NUCB2,SCAND1,MMP9,CARM1	116	
Neurological Disease, Organismal Injury and Abnormalities	degeneration	degeneration of brain	4.12E-06	Decreased	-2.703	bias	-0.528	ADIPOQ,VAC14,GBA,STUB1,GLB1,LYNX1,CYBB,GSK3B,CLCN3,NFE2L2,UNG,NDUFS4,PRNP,PLAT,CNR1,CNP,ASNA1,SOD1,ARSA,NFE2L1,APP,SH3GL1,BCL2L1,MAPT,PPT1,CTSB,PSAP,NAGLU,TPP1,CLCN7	30	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of glycosphingolipid	4.43E-06	 	-0.997	 	-0.467	GM2A,HEXA,UGCG,ARSA,SMPD2,FAS,GRINA,APP,BCL2L1,GBA,GLB1,PSAP,GULP1	13	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral cancer	oral cancer	4.68E-06	 	 	 	 	SULF1,CSTA,NPM1,CTGF,CDH18,FAM19A5,ITGA8,PKM,CXCL12,HRAS,PCDH7,CD83,GPC3,COL15A1,HSP90AB1,ANXA1,RAB38,ERBB4,CXCL14,OAZ1,TUBA1C,GNA13,IGFBP6,PLOD2,TP63,TYROBP,MFAP5,TUBB4B,GNA12,TUBG1,TUBB2A,FGFR2,HAX1,ATIC,FGF1,BCL2L1,EDIL3,ADAM12,BSG,LPAR1,MATN2,IL1RN,DUSP1,IGFBP3,CHI3L1,ADAM9,TMEM176B	47	
Neurological Disease	degeneration	degeneration of central nervous system	4.72E-06	Decreased	-2.847	bias	-0.613	ADIPOQ,VAC14,GBA,STUB1,GLB1,LYNX1,CYBB,GSK3B,CLCN3,NFE2L2,UNG,NDUFS4,PRNP,PLAT,CNR1,CNP,ASNA1,SOD1,ARSA,NFE2L1,APP,SH3GL1,BCL2L1,MAPT,PPT1,CTSB,PSAP,NAGLU,TPP1,CLCN7,SQSTM1	31	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of leukocytes	4.79E-06	Increased	2.188	bias	-0.547	MAF,CTSG,TIGIT,C1QA,PTPRC,ZBTB7B,DUSP3,LTF,CTSS,LAIR1,CNR1,NR1H3,ANXA2,MAP2K3,SFRP1,ADCYAP1,C3AR1,ABHD12,APOE,RAB32,LAPTM5,DDIT3,HLA-A,HYOU1,ADIPOQ,HSPB8,LGALS9,PPIA,FKBP1A,SMARCA4,PRKCE,TPO,NFE2L2,PLAT,CD209,TYROBP,TNFRSF1A,IMPDH2,FCGR2A,APP,GRN,FOS,ITGB2,PSME1,CSF1,TREM2,PPT1,FCER1G,TRAF3,RGMA,PLP1,CD4,MBP,CXCL12,STARD7,CD63,PAX5,CD28,HSPA4,ITGAV,CYBB,RET,KLF2,SPP1,RAB10,RAPGEF3,KLF4,TPSAB1/TPSB2,OSTM1,BCL2L1,CD3G,DUSP1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,IRF8,SIRPA,RAB4A,LEP,TOLLIP,MSR1,PYCARD,KLRD1,CD83,HIF1A,FAS,IRAK1,TNFRSF12A,HLA-G,TACR1,HMOX1,SHC1,THBS1,ANXA1,DUSP10,SAA1,F5,KIT,PRNP,CALR,VCAM1,NPY1R,HSPH1,AP3D1,HPS1,MGAT5,SOD1,HSPD1,CEBPB,NFKBIZ,IL20RB,CSF1R,FGF1,TNFAIP8L2,SLC33A1,PAG1,C6,CHI3L1,ADAM9,MMP9	122	
Protein Trafficking	targeting	targeting of protein	4.79E-06	 	 	 	 	SORL1,ICMT,AHCYL1,TIMM10,PPP1R3C,RAN,XPO5,FOLR2,STXBP4,SEC61A1,RHOD,CSE1L,MICALL1,GSK3B,CALR,YWHAG,SYNGR2,YWHAB,PEX7,HSPA9,RAB7A,HSPA8,FIS1,TOMM22,TSPO,EIF5A,UHMK1,GABARAP,XPO6,NUTF2	30	
Lipid Metabolism, Small Molecule Biochemistry	conversion	conversion of lipid	4.93E-06	Increased	2.183	bias	0.692	SCD,APOE,APOB,LEP,AKR1C3,UGCG,CRAT,CFTR,TECR,IRAK1,CERS2,POR,HMOX1,HSD11B2,CYGB,NFE2L2,PRNP,AKR1C1/AKR1C2,CYB5B,FGFR2,ALOX5AP,SOD1,CYP1B1,STS,APP,FTL,SREBF1,TXN2,MAPT,ME2,C3AR1,CYP4A11,MAP4K4,GSTP1	34	
Cancer, Organismal Injury and Abnormalities	connective or soft tissue tumor	connective or soft tissue tumor	4.98E-06	 	0.544	 	0.772	NPM1,TWF1,RPE,ASS1,PCDHAC1,CTSG,COL8A1,TMEM184B,GPR55,POR,PTPRC,EIF4G2,LTF,PLEKHO2,SLC2A5,ALDH1B1,PLD3,LAIR1,CNR1,FGFR2,RPH3A,CYP4B1,PRKACA,ESR2,TRAPPC5,FTH1,APOE,SLC4A2,DDIT3,PHLDA2,PRDX1,BAG6,GDF15,SEC23B,ZDHHC11B,TECR,COL15A1,COL16A1,HSP90AB1,SORBS1,SERPINA1,RPN1,TUBB4B,LZTS2,ALOX5AP,SLC25A1,THAP11,FOS,MYOC,NTRK3,CSF1,DOPEY2,NR4A1,ADRA1A,SOCS3,MEGF9,AKR1C3,SCN7A,BAG3,MRPL47,MRVI1,CTSD,HS6ST1,HSPA4,TMEM132C,MEGF6,CXCL14,ERAL1,TUBA1C,ADAMTS5,LAMA2,CNP,RAPGEF3,SDHC,ARSA,TXNRD1,DMXL2,BCL2L1,KCNG1,ADAM12,ADRA2A,DUSP1,TXN2,NDUFA6,IGFBP3,CCPG1,POLE3,SCD,LITAF,MSR1,SRPX,SCARA5,PKHD1L1,RPL14,SHC1,COL6A1,RAD23B,TP63,EDNRB,DCTN3,TUBG1,DVL1,PYGB,ATIC,FGF1,CXCL16,RPS15,SLC33A1,MUC17,FECH,MAP4K4,RAP2B,NR6A1,SLC29A4,CPAMD8,APOB,AHCYL1,MAF,HRAS,MKI67,ABCC6,LGMN,CTSS,PXK,POU6F2,PNKD,MED16,TXN,ZBTB16,WNT5B,CALCRL,CAPN6,SLC24A3,TKT,GSTM3,TUBB2A,STOML2,KAZALD1,HMGA1,PCK1,AP2S1,ACAD11,CCND2,RTN4,ALDOA,ME2,SFRP1,CYR61,FH,MYEOV,GSTP1,ALK,SORL1,S100A11,ALDH4A1,RPS3A,UQCRH,HYOU1,FKBP1A,PFKL,SDC3,CDH11,UCHL1,LIPA,IFRD2,SCN3A,TOP2A,TRIM16,PRKCE,ACVR1C,COX4I1,RPS19,LETM1,TYROBP,IMPDH2,EGR1,STXBP6,CYP1B1,ITGB2,COL5A3,SREBF1,NR5A2,P2RY12,CBX4,PLAU,CLUH,NCAM1,PNO1,PLP1,MYH15,MRPL54,MMRN1,NR2F1,CNDP2,DPP3,RPL19,GSK3B,RET,COL27A1,SPP1,ACP2,CDK6,ATP10A,TPSAB1/TPSB2,UBXN11,RPL9,TIE1,PPP2R1A,IL1RN,MAPT,SH2B3,CLCN7,CYP4A11,RBBP8,UGCG,SLC7A1,CFTR,FAS,HINT1,CSPG4,THBS1,PHYH,ERBB4,F5,KIT,MICALL1,WSB2,ALPL,PRNP,FRMD1,COL5A2,DLGAP4,CENPV,HYAL1,GABBR1,ZBTB7C,CEBPB,SLC5A3,CSF1R,THRSP,ARHGEF10L,RPS4Y1,PLCB4,ITPA,GBE1,NUCB2,ADAM9,ATP6V1B2,MMP9,CARM1	250	
Cell Death and Survival, DNA Replication, Recombination, and Repair	fragmentation	fragmentation of DNA fragment	5.15E-06	 	1.707	 	1.047	LEP,UBQLN1,PAM16,CNR1,SOD1,TPSAB1/TPSB2,FAS,APP,ENO1,BCL2L1,MAPT,KEAP1,RTN4,CAPN2,SERPINA1,NACC1,GSK3B	17	
Cellular Assembly and Organization, Cellular Function and Maintenance, Tissue Development	formation	formation of actin stress fibers	5.21E-06	Increased	2.562	bias	0.720	NPM1,PFN1,CTGF,LEP,ARF1,CXCL12,HRAS,SDC4,SLC9A1,CDH11,PHLDB2,SMARCA4,TACR1,GNB1,ARF6,SORBS1,RHOD,PRKCE,DAB2,ARHGEF2,CHCHD2,GNA13,GNG5,ASAP3,KLF2,AMOT,TESK1,GNG12,PLAT,VCAM1,TP63,GNA12,GNG2,CDK6,TPM3,RAPGEF3,JUNB,HAX1,UBXN11,LMCD1,FGF1,KCTD13,MYOC,LPAR1,CDC42,GPR65,ARAP1,C3AR1,SIRPA	49	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of blood cells	5.21E-06	Increased	2.120	 	-0.209	NPM1,APOB,MAF,HRAS,C1QA,SLC35C1,CHST2,PTPRC,ZBTB7B,SGPL1,LGMN,CCND3,CTSS,SPTB,MGAT4B,ST6GALNAC2,ATF4,STAM,GNA13,APEX2,ZBTB16,CALCRL,LAIR1,MFAP5,DKC1,FGFR2,NR1H3,TSPAN33,HAX1,CCND2,IL10RA,TFRC,B3GNT5,ADCYAP1,C3AR1,ESR2,STEAP3,GSTP1,SLC4A4,APOE,ADAM17,DDIT3,PRDX1,PSMB10,HLA-A,NQO2,LRP6,GDF15,ADIPOQ,PPIA,SMARCA4,G6PC3,CES1,GBA,SORBS1,PRKCE,SERPINA1,NFE2L2,PLAT,RPS19,MECOM,TYROBP,TNFRSF1A,FCGR2A,IMPDH2,EGR1,GNA12,SLC6A6,APP,FOS,ITGB2,CSF1,DOCK8,SREBF1,TREM2,BMF,FCER1G,NR4A1,PSAP,ARHGDIA,PLAU,SOCS3,GAB2,TRAF3,PLP1,CD4,MBP,BAG3,CXCL12,STARD7,GPC3,PAX5,CD28,CTSD,PLCE1,COMT,CXCL14,CYBB,STAB1,KLF2,FERMT3,EIF2AK1,SPP1,DNASE2,LAMA2,GCNT2,HSPA9,CDK6,THRA,FYB,KLF4,PKN1,FOSB,CD3G,BCL2L1,ADAM12,IL1RN,DUSP1,SH2B3,XRCC6,MAPT,IGFBP3,PIK3AP1,IRF8,CYP4A11,SIRPA,LITAF,LEP,PYCARD,SLC7A1,CD83,HIF1A,FAS,IRAK1,HLA-G,HMOX1,SHC1,HINT1,PARK7,THBS1,DKK3,FLNA,EFNB1,DUSP10,SAA1,KIT,HCST,MAPKAPK2,ALPL,PRNP,SLC20A1,VCAM1,CYP27A1,NPY1R,NQO1,ST3GAL6,F13A1,VSIG4,SOD1,CEBPB,CSF1R,PSME3,IL20RB,NFE2L1,CXCL16,CAPNS1,TNFAIP8L2,SLC33A1,FASTK,PAG1,C6,CHI3L1,CARM1,MMP9	174	
Cell Morphology	shape change	shape change of tumor cell lines	5.36E-06	Increased	3.610	bias	1.520	RAP2B,GEM,PFN1,CXCL12,HRAS,SMARCA4,CDH11,CLIP1,SYNM,UCHL1,SRPX2,THBS1,FLNA,ANXA5,GNA13,ACVR1C,TESK1,PRNP,FERMT3,VCAM1,EDNRB,GNA12,MGAT5,PVR,FYB,SMPD2,CDC42,CSF1,CAPN2,PLAU,TFPI,SIRPA,MAPRE3,MMP9,CD151	35	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	urinary tract cancer	urinary tract cancer	5.37E-06	 	1.086	 	1.375	REM1,WHSC1,PCLO,VAC14,PLEKHM2,MNAT1,CLIP1,ODC1,NPL,POR,GNB1,EIF4G2,CCND3,GLB1,KEAP1,SPTB,DEFB132,GNA13,SLC2A5,LCP1,PPP1R1B,FGFR2,ANXA2,RCC2,BTG2,NDUFB7,GCC1,ESR2,EPHX1,NME1,PSMD7,OSGIN1,BAG6,CUBN,EEF1B2,MFSD5,PROX1,SMARCA4,ACSS3,HSP90AB1,TNXB,ARFGAP1,PLIN2,ATP5J2,SERPINA1,ALPK2,NFE2L2,S100A1,PLOD2,SRA1,MECOM,TUBB4B,DGAT2,LZTS2,SNCG,FOS,AFF3,FLNC,DOPEY2,MBD3,PSAP,C6orf62,SOX9,BMP6,C11orf68,PCDH18,SESN2,SLC41A3,MBP,DIRAS1,GPC3,LHFPL2,HS6ST1,MEGF6,MOCOS,UQCRFS1,TUBA1C,BCAS2,STK39,RILPL1,LAMA2,KCNK2,SRPRB,GUF1,FOSB,BCL2L1,RPL8,SDCBP,DNAJC5,NDUFA6,IGFBP3,POLE3,CALHM2,PTGFR,SCD,SLC1A4,FAT3,PKHD1L1,ALAS1,HNRNPK,FILIP1,IRAK1,RPL14,PPP1R2,SAA1,LOC102724428/SIK1,LIAS,FAM171B,TP63,NPY1R,TUBG1,NQO1,HPS1,PYGB,ATIC,UTY,CXCL16,POLR3B,PSMD2,MUC17,SLC25A5,SLC29A4,LDB3,HRAS,MKI67,MUC7,PRG4,ZNF605,POU6F2,KIF21A,HADHB,BIRC7,CALCRL,NANOS1,CENPB,TUBB2A,DPY19L1,NINJ1,SH3GL1,CCND2,BSG,IL10RA,ADM2,ARHGAP35,CCT3,MAP2K3,SFRP1,AIDA,TCF7,CYR61,SETBP1,FH,GSTP1,PHLPP1,SLC4A4,S100A11,ADAM17,RALA,KLHL18,BTG3,HLA-A,DUSP6,FKBP1A,XPOT,ATP6AP1,UCHL1,CADM2,MT-CYB,ANXA5,TBC1D12,TOP2A,TRIM16,PRKCE,RPS12,GJB2,PLAT,CD53,CD209,PLXNA1,ACTB,ATXN2L,COL5A3,CLIC6,MRPL51,SREBF2,PPP1R16B,DOCK8,GABARAP,CXCL12,XPO5,TUBB,METAP2,GSPT1,COMT,SIAH2,RET,RAD51C,MFSD3,FERMT3,SLC6A8,ACSL3,TRIOBP,TBC1D2B,SPP1,POLR1A,ANLN,GCNT2,GPAA1,TPSAB1/TPSB2,PPP2R1A,IL1RN,TMOD1,RNPEP,RAB1A,PKM,CFTR,HIF1A,HMOX1,SLFN5,PCK2,CSPG4,FLNA,KCNMA1,THBS1,ERBB4,KIT,ASAP3,CACNG8,CALR,FRMD1,TMEM126B,ADCY2,TPST2,RARS2,AP3D1,PHLDA3,MAP3K1,NXPH4,ZBTB7C,GUK1,NFKBIZ,CSF1R,MT-ND5,LPAR1,GBE1,SLC47A1,MMP9	247	
Cellular Assembly and Organization	formation	formation of tau aggregates	5.37E-06	Increased	2.000	bias	 	AK1,MAPT,MAP3K1,MAPK10,GSK3B	5	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of tumor cell lines	5.47E-06	 	0.147	bias	-1.813	WHSC1,CD4,RACK1,CXCL12,HRAS,CD28,LTF,ST6GALNAC2,ITGAV,CYBB,AFAP1,C1QBP,GNA13,DSP,FERMT3,SPP1,PTP4A3,FGFR2,ANXA2,JUNB,FYB,HAX1,ERP29,ADAM12,BSG,CDC42,CTSB,ALCAM,CYR61,ETV5,RPSA,CD151,APOE,NME1,ADAM17,LEP,MMP14,GDF15,PKM,UCHL1,DKK3,FLNA,THBS1,ANXA1,EFNB1,DAB2,PI4KB,VCAM1,TP63,MECOM,EGR1,HYAL1,MGAT5,FOS,ITGB2,PLAU,ADAM9,NCAM1	58	
Cell Death and Survival	necrosis	necrosis of vascular endothelial cells	5.53E-06	 	0.398	 	0.277	LEP,DDIT3,DUSP6,ADIPOQ,CXCL12,HSPA5,FAS,HMOX1,THBS1,MCAM,PRKCE,SERPINA1,GSK3B,SEMA3B,NFE2L2,SPP1,UCP2,TNFRSF1A,DGKE,HSPD1,FGF1,APP,BCL2L1,IGFBP3,CYCS,VDAC1,MMP9	27	
Gene Expression	binding	binding of DNA	5.54E-06	 	1.911	 	0.557	SOCS3,NPM1,GFPT1,CTGF,WHSC1,CD4,RACK1,CXCL12,HRAS,CEBPG,PTPRC,POR,NR2F1,CD28,LTF,KEAP1,HOXA10,ANXA7,TXN,GSK3B,SPP1,YWHAG,CFL1,YWHAB,PPP1R1B,NR1H3,RAPGEF3,THRA,PCK1,HMGA1,JUNB,FYB,PKN1,TXNRD1,LMCD1,FOSB,IL1RN,MAPT,BTG2,PRKACA,IGFBP3,GAPDH,ADCYAP1,ESR2,GSTP1,ALK,SCD,NME1,LEP,DDIT3,GSTM5,PRDX1,PPIB,ADIPOQ,PPIA,PROX1,HIF1A,SMARCA4,FAS,PHB,ERBB4,TGFB2,PRKCE,NR2F6,MAPKAPK2,NFE2L2,CALR,VCAM1,OAS1,TP63,TNFRSF1A,EGR1,TRIM28,MAP3K1,ZBTB7C,TRIB3,SOD1,CEBPB,NFKBIZ,PSME3,CYP1B1,FGF1,APP,FOS,ITGB2,CALM1 (includes others),SREBF2,SREBF1,NR4A1,NR5A2,SOX9,PLAU,BMP6,SIM1,CARM1	95	
Developmental Disorder, Embryonic Development, Organismal Survival	organismal death	death of embryo	5.89E-06	Decreased	-4.877	bias	 	NR6A1,ATP6V0C,PRPF19,SLC31A1,PFN1,LRP6,MAP1B,RBBP8,EIF6,SMARCA4,METAP2,LIAS,RPS19,IMPDH2,TKT,UROS,TUBG1,PHB2,PSMC4,TPM3,COPS3,TXNRD1,CAPNS1,BSG,LIMS1,KIF5B,ALDH1A2,PRKACA,CAPN2,GNL3,B3GAT3,B3GNT5,RPSA	33	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of sphingolipid	6.02E-06	 	-0.748	 	-0.683	GM2A,HEXA,UGCG,ARSA,SMPD2,FAS,GRINA,APP,BCL2L1,GBA,GLB1,PSAP,IRF8,GULP1	14	
Cellular Development	differentiation	differentiation of cells	6.36E-06	 	1.967	 	-1.674	NPM1,CSTA,REM1,CTSG,C1QC,PANX1,SLC9A1,ODC1,SPRY4,GPR55,PTPRC,POR,FUOM,ALPK3,CCND3,EIF4G2,SRPX2,LTF,KEAP1,MCOLN3,SPTB,ATF4,GNA13,LMX1A,RRAGC,SLC2A5,LCP1,YWHAG,LAIR1,PPP1R1B,CNR1,FGFR2,ANXA2,DES,NDN,HAX1,FSCN1,BTG2,PRKACA,CTSB,GAPDH,ALCAM,TFRC,SQSTM1,ADCYAP1,ESR2,APOE,NME1,USP18,DDIT3,SLC1A5,BAG6,WDR61,ADIPOQ,LGALS9,PPIA,PROX1,ATRAID,SDK1,SMARCA4,ARF6,ACTR3,HSP90AB1,OSBPL11,LY6E,DAB2,CSNK2B,AMOT,NFE2L2,SIGMAR1,SRA1,MECOM,TNFRSF1A,GNA12,TRIB3,HSPA2,CPEB4,GRN,MYO5A,MRAP,FOS,MYOC,KIF7,PIR,NTRK3,FLNC,CSF1,NR4A1,SOX9,BMPER,BMP6,ID4,ADRA1A,SOCS3,TRAF3,AKR1C3,MBP,RACK1,NME2,HSPA5,GPC3,C3orf17,CBX5,BIN1,NNMT,CD28,HS6ST1,RHOG,CXCL14,HOXA10,HOXA7,FSTL3,HDAC2,STK39,PTPRQ,LAMA2,CNP,RAPGEF3,CREG1,THRA,CITED1,KLF4,TXNRD1,SLC3A2,BCL2L1,DUSP1,XRCC6,ALDH1A2,LSM1,IGFBP3,PIK3AP1,IRF8,CBX3,SIRPA,UBE2I,ETV5,DOK5,SULF1,PTGFR,SCD,DDX21,ANGPTL8,SUMO3,AUP1,LEO1,HNRNPK,HLA-G,SHC1,COL6A1,RNH1,IARS,LONP1,TP63,CAPZB,AKR1C1/AKR1C2,EDNRB,NPY1R,HPS1,SOD1,HSPD1,KIF3B,NFE2L1,FGF1,SERPINE2,SHB,RPS15,CAPNS1,KDM5D,KIF5B,TTL,FECH,CHI3L1,CTGF,MAF,ARPC5,HRAS,RPS11,ZBTB7B,SGPL1,DYNLL1,PEG10,POU6F2,ZBTB16,WNT5B,RIMS3,CFL1,TSPAN33,JUNB,HMGA1,ROR1,BCAP29,MTPN,INPP4B,NR1D1,BSG,IL10RA,RTN4,GLUL,MAP2K3,LRP8,SFRP1,CYR61,C3AR1,ALK,ADAM17,RALA,RPS3A,TCEA1,NID2,BTG3,LRP6,HMGN1,GPC4,SDC3,H2AFZ,ATP6AP1,CDH11,MAFG,CES1,PHB,SRGAP1,TOP2A,SNX10,TRIM16,PRKCE,STIM1,SARS,ACVR1C,SMPD3,PLAT,IL11RA,RPS19,TYROBP,EGR1,APP,ITGB2,CCDC85B,GLIS2,TENM4,BRINP2,LIMS1,SREBF1,TREM2,FCER1G,PRMT5,NR5A2,P2RY12,PLAU,NCAM1,NAB2,HOXB5,GAB2,PFN1,PLP1,PRPF19,CD4,MAP1B,UNC5B,CXCL12,TAF10,DYNLT1,CD63,NR2F1,CTBP1,PAX5,CDON,SIAH2,GSK3B,GPC1,C1QBP,RET,DSP,EIF2AK1,IGFBP6,SPP1,FST,DNASE2,LMO4,ANLN,CLTC,ERH,CDK6,PHB2,CDK2AP1,TPSAB1/TPSB2,UBXN11,OSTM1,SEL1L,CD3G,CDC42,IL1RN,SH2B3,MAPT,RARRES3,NUAK1,CD14,GNL3,LFNG,EIF5A,CREBL2,GEM,LEP,SFRP2,ATF5,MMP14,PKM,UGCG,CD83,HIF1A,FAS,TNFRSF12A,SOX17,HMOX1,CCDC88A,NLK,THBS1,KCNMA1,ANXA1,EFNB1,ERBB4,DUSP10,HSPE1,TGFB2,KIT,EGLN3,HCST,SHANK2,ALPL,PRNP,SEMA3E,CALR,CYP27A1,BHLHE41,AP3D1,GABBR1,ZBTB7C,MKNK2,TMEM14C,CEBPB,CSF1R,EDF1,EMP1,ENO1,LPAR1,EPHB3,NUCB2,NCKAP1L,ADAM9,SCAND1,CARM1,MMP9	351	
Neurological Disease, Organismal Injury and Abnormalities	neurodegeneration	neurodegeneration of brain	6.51E-06	Decreased	-2.136	bias	-0.210	ADIPOQ,VAC14,GBA,GLB1,STUB1,CYBB,GSK3B,CLCN3,UNG,PRNP,PLAT,NDUFS4,CNR1,CNP,SOD1,ARSA,NFE2L1,APP,SH3GL1,BCL2L1,MAPT,PPT1,CTSB,PSAP,NAGLU,TPP1,CLCN7	27	
Cell Death and Survival	cell death	cell death of pheochromocytoma cell lines	6.57E-06	 	1.974	 	1.454	NPM1,GEM,PPIA,FAS,SHC1,DYNLL1,ERBB4,GSK3B,RPS3,UCP2,TNFRSF1A,MAP3K1,TRIB3,SOD1,APP,BCL2L1,PPP2R1A,CDC42,IL1RN,MAPT,BTG2,MAPK10,PSAP,GAPDH,CYCS,MAP2K3,PPP2R1B,SIRPA	28	
Cellular Movement	homing	homing of cells	6.77E-06	Increased	4.430	bias	0.348	CTGF,CTSG,HRAS,PTPRC,GNB1,CHST2,ABCC1,AIF1,GNA13,TXN,TMSB10/TMSB4X,LCP1,CNR1,FLOT1,ANXA2,NINJ1,YARS,RTN4,ELMO2,CYR61,C3AR1,APOE,ADAM17,RALA,DAPK2,DUSP6,NQO2,PPIA,LGALS9,PROX1,G6PC3,RHOD,STIM1,SERPINA1,AMOT,RPS19,FCGR2A,TNFRSF1A,GNA12,ANOS1,APP,GRN,ITGB2,MT-ND1,NTRK3,CSF1,SERPINH1,FCER1G,PLAU,SOCS3,PFN1,CD4,CXCL12,TYMP,CD28,RHOG,CXCL14,ITGAV,CYBB,HOXA7,C1QBP,CLCN3,SPP1,CAPG,FYB,TPSAB1/TPSB2,CDC42,IGFBP3,CAPN2,RPL13A,SIRPA,CD151,LITAF,LEP,PPIB,MMP14,FAS,HLA-G,SHC1,CCDC88A,THBS1,SAA1,ERBB4,EFNB1,ANXA1,TGFB2,KIT,SEMA3B,MAPKAPK2,PRNP,SEMA3E,CALR,VCAM1,EDNRB,NQO1,MAP3K1,HSPD1,PLXND1,CSF1R,CXCL16,LPAR1,NCKAP1L,MMP9	103	
Carbohydrate Metabolism	cleavage	cleavage of polysaccharide	6.77E-06	Increased	2.121	bias	 	CTSD,LYZ,LEP,GLB1,MMP14,CTSG,HYAL1,MMP9	8	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities	neuronal ceroid lipofuscinosis	neuronal ceroid lipofuscinosis	6.77E-06	 	 	 	 	GRN,CTSD,DNAJC5,PPT1,TPP1,CLCN7,CLN5,CLN6	8	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	mitochondrial respiratory chain deficiency	mitochondrial respiratory chain deficiency	6.88E-06	 	 	 	 	MT-CO1,SURF1,COA3,NDUFA1,NDUFA2,MT-TN,MT-ND5,MT-ND1,NDUFB9,NDUFS8,NDUFA11,CYC1,NDUFS6,COX14,NDUFA12,UQCRQ,NDUFS4,NDUFAF3	18	
Cellular Compromise, Lipid Metabolism, Small Molecule Biochemistry	peroxidation	peroxidation of lipid	6.88E-06	 	-0.454	 	0.153	SCD,APOE,APOB,LEP,FGFR2,SOD1,IRAK1,CERS2,APP,HMOX1,FTL,TXN2,MAPT,CYGB,C3AR1,CYP4A11,NFE2L2,PRNP	18	
Cell Death and Survival, Nervous System Development and Function, Tissue Morphology	loss	loss of neurons	6.95E-06	 	-1.863	bias	0.377	GDF15,VAC14,ADIPOQ,CTSD,PARK7,ANXA5,MCOLN3,PHYH,CYBB,LMX1A,RET,CLCN3,GJB2,PRNP,SLC4A5,UCP2,MAP3K1,PSMC4,NR1H3,FIG4,SOD1,CEBPB,CLN5,ZPR1,APP,GRN,OSTM1,NTRK3,CSF1,IL1RN,MAPT,PPT1,CTSB,PSAP,ADCYAP1	35	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by granulocytes	6.98E-06	 	-0.875	 	-1.789	APOE,SOCS3,PLCB2,ADAM17,CTGF,PLP1,MSR1,CMA1,NQO2,UNC5B,CTSG,ADIPOQ,PPIA,CFTR,HIF1A,FAS,TACR1,HMOX1,ANXA1,STIM1,SERPINA1,MAPKAPK2,NFE2L2,GJB2,PLAT,PTX3,SPP1,TNFRSF1A,NQO1,HYAL1,ALOX5AP,ITGB2,EDIL3,TNFAIP8L2,IL1RN,CSF1,DUSP1,FCER1G,NR4A1,CTSB,CD14,SFRP1,PLTP,C3AR1,MMP9	45	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of phagocytes	7.16E-06	 	1.147	bias	-0.988	TRAF3,CD4,MAF,STARD7,CD63,LTF,ITGAV,CYBB,SPP1,CNR1,NR1H3,RAPGEF3,ANXA2,KLF4,OSTM1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,MAP2K3,SFRP1,SIRPA,ABHD12,APOE,LEP,TOLLIP,MSR1,DDIT3,HLA-A,ADIPOQ,HSPB8,LGALS9,PPIA,FKBP1A,FAS,IRAK1,TNFRSF12A,HMOX1,SHC1,THBS1,ANXA1,DUSP10,SAA1,F5,KIT,PRKCE,PLAT,PRNP,CD209,CALR,TYROBP,TNFRSF1A,FCGR2A,SOD1,HSPD1,CEBPB,CSF1R,APP,GRN,ITGB2,TNFAIP8L2,CSF1,TREM2,PPT1,FCER1G,C6,CHI3L1,ADAM9,MMP9	70	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of amino acids	7.48E-06	Increased	3.249	bias	 	LEP,SLC1A4,SLC7A11,PYCARD,SLC1A5,ARL6IP5,HRAS,SLC7A1,SLC38A1,SLC9A1,CD28,ABCC1,ERBB4,SLC7A5,CRYM,SLC6A8,SLC25A13,STXBP1,SOD1,SLC38A3,APP,SLC3A2,SERINC2,SLC25A22,SLC36A1,SLC7A2,GLUL,ADCYAP1,FH,ABCC3	30	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of macrophages	7.76E-06	 	1.401	bias	-0.476	ABHD12,APOE,TRAF3,TOLLIP,LEP,DDIT3,MSR1,HLA-A,CD4,MAF,ADIPOQ,IRAK1,TNFRSF12A,HMOX1,LTF,THBS1,DUSP10,CYBB,ITGAV,PRKCE,PLAT,PRNP,TYROBP,NR1H3,RAPGEF3,ANXA2,SOD1,HSPD1,CEBPB,CSF1R,KLF4,APP,OSTM1,TNFAIP8L2,IL1RN,CSF1,TREM2,PPT1,MAPT,SLC7A2,FCER1G,CD14,CLCN7,MAP2K3,C6,CHI3L1,SIRPA,MMP9	48	
Cancer, Cardiovascular Disease, Organismal Injury and Abnormalities	vascular tumor	vascular tumor	7.92E-06	 	 	 	 	CXCL12,HRAS,MKI67,NPAS2,ADGRL1,CEBPG,POR,PAX5,PLCE1,CCND3,KEAP1,CXCL14,STAB1,ANXA7,TUBA1C,RET,COL27A1,TUBB2A,FGFR2,SDHC,BCL2L1,PPP2R1A,INPP4B,CCND2,ADCYAP1R1,CDH20,SH2B3,IGFBP3,ALCAM,FH,SETBP1,GSTP1,ALK,CARS,GSTM5,DDIT3,HLA-A,MMP14,CUBN,HMGN1,LRP6,CTNNA1,HIF1A,DCLK1,SMARCA4,MLH1,FANCE,CADM2,HSP90AB1,THBS1,TOP2A,KIT,MYH1,RPN1,VCAM1,EDNRB,MECOM,TUBB4B,TUBG1,NQO1,RNF43,MAP3K1,NFKBIZ,CSF1R,CYP1B1,SERPINE2,AFF3,ITPA,LPAR1,NTRK3,EPHB3	71	
Cell Cycle	interphase	interphase of tumor cell lines	8.31E-06	Increased	2.294	 	1.698	NPM1,PRPF19,RRM2B,HRAS,MNAT1,MTCH2,GSPT1,CCND3,CSE1L,GORASP2,HOXA10,UBL5,ITGAV,BIRC7,SPP1,YWHAG,GPS2,CDK6,CREG1,ANXA2,HMGA1,KLF4,SEL1L,CCND2,CDC42,DUSP1,RBX1,BTG2,TFRC,NUAK1,MAP2K3,GNL3,CYR61,ESR2,SULF1,LEP,DDIT3,ATF5,OSGIN1,GDF15,RBBP8,ADIPOQ,DTD1,RPL7A,MLH1,SYNM,HLA-G,HMOX1,SHC1,RABL6,KIT,TCP1,DAB2,PRKCE,NFE2L2,PRNP,TAF6,TP63,PPIF,HYAL1,CEBPB,CYP1B1,DEGS1,RBCK1,NR5A2,PSAP,SOX9,PLAU,MMP9,ADRA1A	70	
Cellular Movement	chemotaxis	chemotaxis	8.34E-06	Increased	4.448	bias	0.501	SOCS3,PFN1,CTGF,CD4,CXCL12,CTSG,HRAS,TYMP,PTPRC,GNB1,CD28,RHOG,ABCC1,CXCL14,ITGAV,CYBB,HOXA7,TXN,GNA13,AIF1,C1QBP,TMSB10/TMSB4X,CLCN3,LCP1,SPP1,CNR1,FLOT1,CAPG,ANXA2,TPSAB1/TPSB2,NINJ1,CDC42,YARS,RTN4,CAPN2,CYR61,ELMO2,C3AR1,SIRPA,RPL13A,CD151,APOE,LITAF,ADAM17,LEP,RALA,PPIB,DAPK2,DUSP6,MMP14,LGALS9,PPIA,PROX1,G6PC3,FAS,HLA-G,SHC1,CCDC88A,RHOD,THBS1,ERBB4,SAA1,EFNB1,ANXA1,TGFB2,KIT,SERPINA1,STIM1,SEMA3B,MAPKAPK2,AMOT,PRNP,SEMA3E,RPS19,CALR,VCAM1,EDNRB,TNFRSF1A,FCGR2A,GNA12,MAP3K1,ANOS1,HSPD1,PLXND1,CSF1R,APP,GRN,ITGB2,CXCL16,MT-ND1,LPAR1,CSF1,NTRK3,SERPINH1,FCER1G,PLAU,NCKAP1L,MMP9	98	
Cell Death and Survival	apoptosis	apoptosis of endothelial cells	8.54E-06	 	-0.470	 	-0.568	ICMT,ADAM17,LEP,DDIT3,PSMB10,ASS1,DUSP6,ADIPOQ,CXCL12,PPIA,HRAS,TYMP,HSPA5,FAS,LIPA,HMOX1,THBS1,MCAM,PRKCE,SERPINA1,TXN,GSK3B,SEMA3B,MAPKAPK2,NFE2L2,PLAT,SPP1,UCP2,TNFRSF1A,CNP,DGKE,HSPD1,APP,BCL2L1,EDIL3,PRKACA,CYCS,VDAC1,MMP9	39	
Cell-To-Cell Signaling and Interaction	fusion	fusion of cells	8.65E-06	Increased	2.130	bias	0.357	SLC4A2,CD4,MMP14,CXCL12,PANX1,ARF6,CDON,ANXA5,ANXA1,NEO1,STIM1,GSK3B,KLF2,TPST2,CLTC,LAMA2,RAPGEF3,THRA,SOD1,SLC3A2,OSTM1,SDCBP,ADAM12,CSF1,FLNC,CTSB,CAPN2,ELMO2,ADAM9,SIRPA	30	
Infectious Diseases	replication	replication of virus	8.79E-06	Increased	5.203	 	2.871	NPM1,AHCYL1,TXNL4A,HRAS,PANX1,MNAT1,PTPRC,SGPL1,DUSP3,CSE1L,ATF4,MGAT1,FGFR2,COPB1,NRBP1,FSCN1,IL10RA,PRKACA,MAP2K3,ATP6V0B,GBP1,PRDX1,DAPK2,FKBP1A,PPIA,LGALS9,DCLK1,ATP6AP1,DCLK2,RPL35,HSP90AB1,ANXA5,SNX10,LY6E,SERPINA1,PSMD14,RPS5,CD209,SIGMAR1,OAS1,TNFRSF1A,EGR1,RPS10,STX10,COPG1,EIF3G,LAMP2,RPS16,PLAU,CLUH,SOCS3,EEF1A1,PCDH18,CD4,PRMT3,RABEP1,CXCL12,TUBB,CTBP1,NR2F1,CD28,SAE1,STAB1,MID1IP1,HOXA7,GSK3B,PTX3,FERMT3,SPP1,HDAC2,STK39,SNRPF,ATP6V1A,BCL2L1,DUSP1,CDC42,ATP6V0D1,LSM1,RARRES3,RPL13A,RPSA,ATP6V0C,MSR1,EIF2S1,NAA10,MLH1,HMOX1,TGFB2,LONP1,PRNP,AGFG1,EXOSC5,F13A1,HSPD1,FAU,PSMD2,MAP4K4,MMP9,ATP6V1B2	99	
Cell Morphology	cell spreading	cell spreading of tumor cell lines	8.86E-06	Increased	3.211	bias	1.405	RAP2B,PFN1,CXCL12,HRAS,CLIP1,CDH11,SYNM,UCHL1,FLNA,THBS1,TESK1,PRNP,FERMT3,VCAM1,EDNRB,MGAT5,PVR,FYB,CDC42,CAPN2,PLAU,TFPI,MMP9,MAPRE3,SIRPA,CD151	26	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of brain	9.04E-06	 	-0.396	 	-0.396	APOE,ADIPOQ,SH3GLB1,CERS2,APP,MAPT,PPT1,CLCN7,GSK3B,HPGDS,ATP13A2,PRNP,NDUFS4	13	
Cell Morphology, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development, Tissue Morphology	morphology	morphology of osteoclasts	9.04E-06	 	 	 	 	PTPRC,GAB2,SLC4A2,INPP4B,CD68,TYROBP,CSF1,GPR65,ADIPOQ,CLCN7,CEBPB,CSF1R,GPR55	13	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small-cell lung carcinoma	stage 1 metastatic non-small-cell lung carcinoma	9.23E-06	 	 	 	 	EEF1A1,FTL,SEC61G,NDUFB4,EIF4A1,IFI30,PPIA,RNASE1,TMSB10/TMSB4X,CLCN3,RPS11,MYL12A	12	
Carbohydrate Metabolism	synthesis	synthesis of polysaccharide	9.24E-06	 	-0.144	bias	-1.482	APOE,SOCS3,GFPT1,B3GALT6,CTGF,LEP,PPP1R3C,HS2ST1,ADIPOQ,HRAS,HEXA,HS6ST1,GYS1,CCND3,LTF,SORBS1,TGFB2,CHST11,GSK3B,GPC1,ADCY2,SPP1,XYLT1,GCNT2,RAB10,HYAL1,CSF1R,NR1D1,BSG,NTRK3,IL1RN,CSF1,SREBF1,NR4A1,IGFBP3,GBE1,SFRP1,B3GAT3	38	
Cellular Function and Maintenance	engulfment	engulfment of tumor cell lines	9.25E-06	Increased	4.299	bias	 	APOE,ATP6V0C,RALA,PFN1,RACK1,CXCL12,FAT3,ATP6AP1,CLIP1,HMOX1,ARF6,RHOG,MT-CYB,ANXA1,DAB2,PRKCE,KLF2,PTX3,CD209,CALR,FCGR2A,CLTC,RAPGEF3,RPS21,CEBPB,HAX1,ATP6V1E1,ATP6V1F,CDC42,TREM2,ATP6V0D1,ATP6V1B2	32	
Cellular Assembly and Organization, Cellular Function and Maintenance, Tissue Development	formation	formation of actin filaments	9.62E-06	Increased	2.835	bias	0.705	NPM1,TWF1,PFN1,CTGF,ARF1,CXCL12,HRAS,SDC4,SLC9A1,GNB1,CHCHD2,AIF1,GNA13,KLF2,TESK1,GNG12,CFL1,GNG2,CDK6,TPM3,RAPGEF3,JUNB,MLST8,UBXN11,HAX1,LMCD1,CDC42,GPR65,C3AR1,SIRPA,LEP,PYCARD,SMARCA4,CDH11,PHLDB2,TACR1,ARF6,ACTR3,TWF2,RHOD,SORBS1,DAB2,PRKCE,ARHGEF2,GNG5,ASAP3,AMOT,PLAT,VCAM1,TP63,FCGR2A,GNA12,MAP3K1,FGF1,KCTD13,MYOC,LPAR1,ARAP1,NCKAP1L	59	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	cell death	cell death of kidney cells	1.00E-05	 	0.872	 	-0.325	GFPT1,CTGF,CCNI,UNC5B,HRAS,HSPA5,SGPL1,RHOG,CDON,MCOLN3,ABCC1,ITGAV,NEO1,GSK3B,GNA13,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,DUSP1,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,SFRP1,VDAC1,GSTP1,APOE,GSTM5,DDIT3,PYCARD,LRP6,HYOU1,HIF1A,FAS,STUB1,ERBB4,AAK1,NFE2L2,GMFB,ATP13A2,PRNP,TMEM123,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,FGF1,APP,EMP1,FOS,MYOC,TNFAIP8L2,GLIS2,NTRK3,SREBF2,CSF1,PEA15,CYCS,SLC47A1	66	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of myeloid cells	1.05E-05	 	1.392	bias	-0.781	TRAF3,CD4,MAF,CD63,LTF,ITGAV,CYBB,RET,SPP1,CNR1,NR1H3,RAPGEF3,ANXA2,KLF4,OSTM1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,MAP2K3,SFRP1,SIRPA,ABHD12,APOE,LEP,TOLLIP,MSR1,DDIT3,HLA-A,ADIPOQ,PPIA,FKBP1A,IRAK1,TNFRSF12A,HMOX1,SHC1,THBS1,ANXA1,DUSP10,SAA1,F5,KIT,PRKCE,PRNP,PLAT,VCAM1,TYROBP,FCGR2A,SOD1,HSPD1,CEBPB,CSF1R,APP,GRN,ITGB2,TNFAIP8L2,CSF1,TREM2,PPT1,FCER1G,C6,CHI3L1,ADAM9,MMP9	65	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	gastrointestinal tract cancer	metastatic gastrointestinal tract cancer	1.06E-05	 	 	 	 	SLC7A11,CTGF,AKR1C3,CXCL12,GYG2,POR,NR2F1,CSE1L,HOXA10,TUBA1C,RET,PTX3,FST,FSTL3,TUBB2A,KCNK2,FGFR2,CAPG,EFS,ISLR,CCND2,GLUL,NUAK1,DUSP4,TFPI,GSTP1,STEAP3,POLE3,ERAP2,MSC,SRPX,TCEA1,EPB41L3,PDGFA,DUSP6,GDF15,FAS,HMOX1,HSP90AB1,ERBB4,TOP2A,TGFB2,KIT,PRNP,PLAT,PLOD2,VCAM1,AKR1C1/AKR1C2,FCGR2A,TUBB4B,TUBG1,SLC5A3,FGF1,EMP1,CLGN,PLAU	56	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small cell lung cancer	stage 1-2 non-small cell lung cancer	1.07E-05	 	 	 	 	EEF1A1,NDUFB4,SEC61G,XPO5,PPIA,ANXA2,RNASE1,ATIC,RPS11,FTL,ERBB4,EIF4A1,IFI30,CLCN3,TMSB10/TMSB4X,MYL12A	16	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	malignant neoplasm of digestive system	metastatic malignant neoplasm of digestive system	1.08E-05	 	 	 	 	SLC7A11,CTGF,AKR1C3,CXCL12,GYG2,POR,NR2F1,CSE1L,HOXA10,TUBA1C,RET,PTX3,FST,FSTL3,TUBB2A,KCNK2,FGFR2,CAPG,EFS,ISLR,CCND2,GLUL,NUAK1,DUSP4,TFPI,GSTP1,STEAP3,POLE3,ERAP2,MSC,SRPX,TCEA1,EPB41L3,PDGFA,DUSP6,GDF15,FKBP1A,FAS,HMOX1,HSP90AB1,ERBB4,TOP2A,TGFB2,KIT,PLAT,PRNP,PLOD2,VCAM1,AKR1C1/AKR1C2,FCGR2A,TUBB4B,TUBG1,SLC5A3,CSF1R,FGF1,EMP1,CLGN,PLAU	58	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	large intestine neoplasm	large intestine neoplasm	1.09E-05	 	-0.391	 	-0.039	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,GLB1,DEFB132,GNA13,DCAF12,SYT17,SRPRA,ANXA2,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,PYGB,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,CCAR2,RUVBL1,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CCDC68,CD209,SLC25A13,RRP1B,ANKRD9,TRIM28,EGR1,ZFY,COPS3,STS,AOX1,NCAM1,CLUH,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PLCE1,DPP3,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,DGAT2,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,ADRA1A,BZW2,NCDN,TMEM8A,SLC41A3,NTMT1,ACO2,BAG3,NME2,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,PACS2,HOXA10,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,PRMT5,P2RY12,MAPRE3,MVD,GAB2,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,HSPA13,STXBP5,PHF1,AKR1B1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,CENPV,C10orf71,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,RAN,GYG2,GHITM,MKI67,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,FARSA,NGRN,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,CDH11,ENAH,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,SLC48A1,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,GSPT1,CAMK2D,SLC25A6,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,DHX32,MDH2,BCKDK,DSP,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,RRAGD,ERBB4,HSPE1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,NEXN,PLEKHM2,MNAT1,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,TIMM8B,FLOT1,FGFR2,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,HSPA2,FOS,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,DOPEY2,MBD3,ABCC3,SIGLEC6,CSTF3,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,SLC24A2,RAB32,ADAM17,MSC,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,B4GALT2,FIS1,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,UTP4,TAF10,MMRN1,TUBB,VDAC2,NR2F1,RAB11FIP2,CTBP1,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,RAB10,CDK6,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,SOX17,TACR1,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,SLC27A3,MAT2A,USP9Y,RTN3	1022	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial leukoencephalopathy	mitochondrial leukoencephalopathy	1.13E-05	 	 	 	 	MT-ATP6,MT-TY,RRM2B,SURF1,MT-TC,TYMP,NDUFA2,SCO2,MT-ND1,MT-ND5,NDUFS8,NDUFA12,MPV17,NDUFS4	14	
Cell Death and Survival	apoptosis	apoptosis of vascular endothelial cells	1.17E-05	 	0.155	 	-0.039	UCP2,SPP1,LEP,DDIT3,TNFRSF1A,DUSP6,ADIPOQ,CXCL12,DGKE,HSPD1,HSPA5,FAS,APP,HMOX1,BCL2L1,THBS1,MCAM,PRKCE,CYCS,SERPINA1,GSK3B,SEMA3B,VDAC1,MMP9	24	
Cellular Function and Maintenance	function	function of blood cells	1.19E-05	 	0.676	bias	-0.216	TIGIT,PANX1,PTPRC,CHST2,BCAT1,LGMN,CTSS,ABCC1,LCP1,FLOT1,NINJ1,IL10RA,DUSP4,MAP2K3,TCF7,ADCYAP1,C3AR1,APOE,HLA-A,PSMB10,GDF15,ADIPOQ,LGALS9,PPIA,G6PC3,NFE2L2,PLAT,CD209,SIGMAR1,PLXNA1,UCP2,MECOM,IMPDH2,FCGR2A,TNFRSF1A,TYROBP,EGR1,TRIB3,GRN,ITGB2,MARCKSL1,FOS,DOCK8,CSF1,TREM2,FCER1G,PSAP,P2RY12,ARHGDIA,PLAU,GAB2,TRAF3,PLCB2,CD4,CMA1,UNC5B,CXCL12,CBX5,GPC3,CEBPG,CD28,RHOG,IFI30,CYBB,CLCN3,KLF2,NSMAF,EIF2AK1,SPP1,CAPG,FYB,PKN1,BCL2L1,CD3G,EFS,DUSP1,CDC42,CD14,EIF5A,IRF8,SIRPA,LEP,MSR1,PYCARD,MMP14,IRAK1,HLA-G,FLNA,CSPG4,TGFB2,KIT,HCST,NPY1R,VSIG4,CEBPB,HSPD1,NFKBIZ,IL20RB,CSF1R,TNFAIP8L2,FASTK,CHI3L1,MMP9	103	
Cellular Movement	migration	migration of cancer cells	1.23E-05	Increased	4.077	bias	2.204	GAB2,CTGF,LEP,SFRP2,MMP14,ADIPOQ,CXCL12,HRAS,PROX1,SMARCA4,THBS1,CSE1L,MCAM,TGFB2,HOXA7,PRKCE,RHOBTB2,SIAH2,RET,ZBTB16,AHCY,VCAM1,SPP1,TP63,GNA12,MAP3K1,RAPGEF3,CSF1R,KLF4,CDC42,CSF1,DUSP1,CTSB,ALCAM,SFRP1,PLAU,ESR2,SIRPA,MMP9,CD151	40	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	follicular thyroid tumor	follicular thyroid tumor	1.24E-05	 	 	 	 	CALR,SPP1,HRAS,FGFR2,THRA,CSF1R,NDUFA13,MT-ND1,HSP90AB1,PARK7,THBS1,SRGAP1,ANXA5,CTSB,KIT,TPO,RET,AMOT,GSTP1,MMP9	20	
Cardiovascular Disease, Organismal Injury and Abnormalities	acute coronary syndrome	acute coronary syndrome	1.24E-05	 	-0.393	 	0.242	APOB,CXCL12,NPC1L1,NNMT,ITGAV,CYBB,TUBA1C,GSK3B,GCLM,PTX3,CNR1,TUBB2A,THRA,VKORC1,ADRA2A,IL1RN,SH2B3,RTN4,CD14,LRP8,TFPI,APOE,LEP,DUSP6,GDF15,ADIPOQ,HIF1A,HMOX1,PRKCE,MAPKAPK2,PLAT,PPIF,FCGR2A,TUBB4B,TNFRSF1A,TUBG1,F13A1,SOD1,CSF1R,APP,ITGB2,CSF1,FCER1G,CCT7,TSPO,P2RY12,C6,MMP9,ADRA1A	49	
Cell-To-Cell Signaling and Interaction	activation	activation of cells	1.24E-05	Increased	3.064	bias	-0.120	RAP2B,NPM1,CTGF,APOB,MAF,TIGIT,CTSG,C1QA,MNAT1,PTPRC,ZBTB7B,DUSP3,LTF,CTSS,SPTB,GNA13,CFL1,LAIR1,CNR1,NR1H3,ANXA2,NDN,IL10RA,MAP2K3,SFRP1,SQSTM1,PLTP,CYR61,ADCYAP1,C3AR1,PHLPP1,ABHD12,APOE,RAB32,LAPTM5,SLC4A2,DDIT3,HLA-A,HSPB8,HYOU1,ADIPOQ,LGALS9,PPIA,FKBP1A,SMARCA4,PRKCE,SERPINA1,STIM1,TPO,NFE2L2,PLAT,CD209,TYROBP,TNFRSF1A,FCGR2A,IMPDH2,APP,GRN,FOS,ITGB2,PSME1,CSF1,TREM2,PPT1,FCER1G,NR4A1,PRMT5,P2RY12,BMPER,PLAU,RGMA,TRAF3,PLP1,CD4,MBP,CXCL12,STARD7,CD63,PAX5,CD28,HSPA4,LYNX1,CYBB,ITGAV,RET,KLF2,STXBP1,SPP1,RAB10,RAPGEF3,THRA,SMPD2,KLF4,TPSAB1/TPSB2,OSTM1,BCL2L1,CD3G,ADAM12,IL1RN,DUSP1,MAPT,SLC7A2,NUAK1,CD14,CLCN7,PLEK,IRF8,SIRPA,RAB4A,TOLLIP,LEP,F2RL3,MSR1,PDGFA,PYCARD,KLRD1,MMP14,PKM,CD83,HIF1A,FAS,IRAK1,TNFRSF12A,TACR1,HLA-G,HMOX1,SHC1,THBS1,KCNMA1,ANXA1,ERBB4,DUSP10,SAA1,F5,TGFB2,KIT,PRNP,CALR,VCAM1,TP63,NPY1R,HSPH1,AP3D1,HPS1,MGAT5,TRPA1,F13A1,SOD1,HSPD1,CEBPB,NFKBIZ,CSF1R,IL20RB,FGF1,SERPINE2,TNFAIP8L2,SLC33A1,PAG1,NUCB2,C6,CHI3L1,ADAM9,MMP9	163	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of filaments	1.27E-05	 	1.684	bias	0.701	ADAMTS8,SFRP2,ARF1,FKBP1A,TUBB,ENAH,ARF6,FLNA,TNXB,TGFB2,AFAP1,ARHGEF2,RET,DSP,PLOD3,ACTN1,PRNP,LCP1,AGFG1,COL5A2,CFL1,MFAP5,CNP,DVL1,MGAT5,ANXA2,MFAP4,SOD1,DES,CYP1B1,P4HA1,ADAM12,CDC42,SERPINH1,ARAP1,GAPDH,ALDOA,CDK2AP2,PLAU,TMOD1,RUFY3,SIRPA	42	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	central nervous system tumor	central nervous system tumor	1.28E-05	 	0.920	 	0.803	NPM1,ADAMTS8,LDB3,CA12,HRAS,MKI67,MUC7,CLIP1,PRG4,EIF4G2,MCOLN3,MGAT4B,ALDOC,LCP1,SV2B,FAM126B,FGFR2,ANXA2,HSPA8,PYGO2,CCND2,CD300C,BTG2,MS4A7,ALCAM,ARHGAP35,SFRP1,SETBP1,TRAPPC5,NME1,CDH18,GSTM5,GBP1,HLA-A,ARL4C,BAG6,HMGN1,GDF15,HYOU1,FKBP1A,H2AFZ,SMARCA4,TNXB,TOP2A,PRKCE,LURAP1L,MYO1D,ALPK2,PLXNA1,CD209,SLC25A13,MECOM,TNFRSF1A,IMPDH2,SPTLC3,HSPA2,GRN,SNTG2,COL5A3,CLDN5,KIF7,NTRK3,FLNC,BMF,PRMT5,SOX9,CBX4,AOX1,PLAU,ABCC3,BMP6,NCAM1,NAB2,VAMP5,MBP,SCN7A,BAG3,TMEM147,CXCL12,DIRAS1,HSPA5,BIN1,HS6ST1,LYNX1,RPL21,FAR2,ITGAV,ANXA7,GOT1,GSK3B,RET,ADAMTS5,PTX3,PFKFB3,TRIOBP,SPP1,HDAC2,YWHAB,TNPO1,CDK6,ATP6V1A,KLF4,DMXL2,BCL2L1,PPP2R1A,ADAM12,CLCN7,UHRF1BP1L,TFPI,SIRPA,RNPEP,RAB1A,MSR1,ATF5,PYCARD,MMP14,PKM,CFTR,HIF1A,FAS,MLH1,IRAK1,CLCN4,SOX17,HLA-G,COL6A1,PREPL,CSPG4,THBS1,FLNA,DKK3,KCNMA1,ANXA1,ERBB4,TGFB2,KIT,CYGB,NR2F6,CTDNEP1,ACTN1,TRAF7,SEC61G,VCAM1,AKR1C1/AKR1C2,RARS2,VANGL1,RNF43,MAP3K1,SYNPO2,CSF1R,ATIC,ANO2,FGF1,CXCL16,SHB,LPAR1,MUC17,C6,CHI3L1,ADAM9,MAP4K4,MMP9	162	
Cell Death and Survival, Skeletal and Muscular Disorders	apoptosis	apoptosis of muscle cells	1.31E-05	 	-0.564	 	0.538	SOCS3,CXCL12,CTSG,HRAS,MKI67,MNAT1,CAMK2D,CYBB,GSK3B,DSP,CALCRL,SPP1,HDAC2,FSTL3,LAMA2,NDN,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,ALDOA,MAP2K3,CYR61,LEP,DUSP6,ADIPOQ,HSPB8,HIF1A,FAS,IRAK1,SHC1,HMOX1,PHB,PARK7,STUB1,HSPE1,KIT,MAPKAPK2,HSPB6,S100A1,CALR,TNFRSF1A,MAP3K1,HSPD1,CSF1R,APP,LIMS1,CYCS,ADRA1A	51	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	Mitochondrial complex I deficiency	Mitochondrial complex I deficiency	1.33E-05	 	 	 	 	MT-ND5,NDUFB9,MT-ND1,NDUFS8,NDUFA11,NDUFS6,NDUFA12,NDUFA1,NDUFA2,MT-TN,NDUFS4,NDUFAF3	12	
Cellular Growth and Proliferation	colony formation	colony formation	1.34E-05	 	1.908	 	1.109	NPM1,WHSC1,HRAS,EIF6,SPRY4,KLF8,BIRC7,PTP4A3,TPM3,FGFR2,HMGA1,JUNB,NDN,CTSB,SFRP1,SQSTM1,CYR61,ESR2,ALK,ADAM17,NME1,RALA,DDIT3,ADIPOQ,RUVBL1,PHB,SERPINA1,S100A1,RPS19,MECOM,EGR1,LZTS2,GRN,FOS,CSF1,NTRK3,PEA15,PLAU,ID4,ICMT,TRAF3,VPS28,CD4,RACK1,CXCL12,NME2,GPC3,BIN1,CTSD,HOXA10,NUPR1,ANXA7,C1QBP,RET,PTX3,SPP1,HSPA9,CLTC,THRA,KLF4,SLC3A2,SEL1L,BCL2L1,IL1RN,CDC42,LIMA1,IGFBP3,IRF8,IGFBP4,SFRP2,LEP,EPB41L3,PYCARD,MMP14,LEO1,HIF1A,FAS,SHC1,HMOX1,PSMD10,ERBB4,MCAM,ANXA1,TGFB2,RHOBTB2,KIT,SELENOH,SEMA3B,TP63,DVL1,MAP3K1,SOD1,MKNK2,CSF1R,ATIC,ENO1,MMP9	97	
Cellular Function and Maintenance	function	function of leukocytes	1.36E-05	 	0.676	 	-0.155	GAB2,PLCB2,TRAF3,CMA1,CD4,UNC5B,TIGIT,CXCL12,PANX1,CBX5,CEBPG,CHST2,PTPRC,CD28,BCAT1,RHOG,LGMN,CTSS,ABCC1,CYBB,IFI30,CLCN3,NSMAF,KLF2,LCP1,SPP1,FLOT1,CAPG,FYB,PKN1,NINJ1,EFS,CD3G,BCL2L1,DUSP1,IL10RA,CD14,MAP2K3,DUSP4,EIF5A,IRF8,TCF7,ADCYAP1,C3AR1,SIRPA,APOE,LEP,MSR1,PSMB10,PYCARD,HLA-A,MMP14,GDF15,ADIPOQ,LGALS9,PPIA,G6PC3,IRAK1,HLA-G,CSPG4,TGFB2,KIT,HCST,PLAT,PLXNA1,SIGMAR1,CD209,UCP2,TYROBP,TNFRSF1A,FCGR2A,NPY1R,IMPDH2,EGR1,TRIB3,HSPD1,CEBPB,NFKBIZ,CSF1R,IL20RB,GRN,FOS,MARCKSL1,ITGB2,TNFAIP8L2,CSF1,DOCK8,TREM2,FASTK,FCER1G,PSAP,ARHGDIA,PLAU,CHI3L1,MMP9	95	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	neoplasia	Gastrointestinal Tract Cancer and Tumors	1.36E-05	 	-0.653	 	0.213	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,VAT1,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CCDC68,CD209,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),AOX1,NCAM1,CLUH,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,CHST11,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,HINT1,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,RAB38,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,APOE,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,SIGMAR1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,DGAT2,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ADRA1A,BZW2,NCDN,MEGF9,TMEM8A,SLC41A3,NTMT1,ACO2,BAG3,NME2,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,CXCL14,PACS2,HOXA10,HOXA7,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,SDHC,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,CHI3L1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,ACSF2,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,PRMT5,P2RY12,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,IL1RN,HSPA13,STXBP5,PHF1,AKR1B1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,RBM18,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,NPM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,TUBB4B,SLC25A1,SPATS2L,PVR,CSTB,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,SOCS3,PCDH18,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,C2orf83,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,RPL18A,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,HOXA6,RAN,GYG2,GHITM,MKI67,GSS,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,NGRN,FARSA,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,SDCCAG3,CDH11,ENAH,LYZ,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,SLC48A1,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,CD63,GSPT1,CAMK2D,SLC25A6,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,DHX32,MDH2,BCKDK,DSP,PCNXL2,C7orf50,HK1,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,EIF5A,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,NEXN,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,FGFR2,TIMM8B,FLOT1,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,DOPEY2,MBD3,ABCC3,CSTF3,SIGLEC6,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,SLC25A39,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,BSG,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,MSC,SLC24A2,RAB32,ADAM17,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,COX4I1,MYH1,DNAH12,LETM1,ADRM1,DTX4,TYROBP,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,SDC4,TAF10,TUBB,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RPL13A,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,TACR1,SOX17,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,DIP2C,LPAR1,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1079	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of phagocytes	1.38E-05	 	-0.313	 	-1.511	APOE,PFN1,DDIT3,CXCL12,CTSG,FAS,CD28,HMOX1,THBS1,ANXA1,KIT,PLAT,PTX3,VCAM1,SPP1,TYROBP,FCGR2A,EGR1,FGFR2,SOD1,FGF1,GRN,ITGB2,TNFAIP8L2,EDIL3,CSF1,DOCK8,IL1RN,NR4A1,PLAU,C6,MMP9	32	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small-cell lung carcinoma	stage I-IIIA non-small-cell lung carcinoma	1.38E-05	 	 	 	 	EEF1A1,NDUFB4,SEC61G,XPO5,PPIA,ANXA2,RNASE1,ATIC,RPS11,FTL,ERBB4,EIF4A1,IFI30,CLCN3,TMSB10/TMSB4X,MYL12A	16	
Cellular Development, Tissue Development	differentiation	differentiation of bone	1.40E-05	 	-0.363	 	-1.155	GAB2,SOCS3,RACK1,GPC3,RPS11,GPR55,DYNLL1,LTF,HOXA10,ATF4,GSK3B,WNT5B,SPP1,FSTL3,CLTC,ERH,CDK6,FGFR2,RAPGEF3,JUNB,CITED1,BCAP29,KLF4,OSTM1,INPP4B,PRKACA,TFRC,MAP2K3,LRP8,SFRP1,SQSTM1,CYR61,C3AR1,SIRPA,DDX21,APOE,LEP,SFRP2,SLC1A5,MMP14,BAG6,ADIPOQ,LGALS9,HIF1A,ATRAID,ATP6AP1,FAS,COL6A1,PHB,ERBB4,EFNB1,HSPE1,TGFB2,SNX10,LY6E,HCST,IARS,ALPL,TP63,TYROBP,GABBR1,SOD1,CEBPB,CSF1R,FOS,RPS15,CAPNS1,MYOC,LPAR1,CSF1,TREM2,FCER1G,BMPER,BMP6,ID4	75	
Connective Tissue Development and Function, Tissue Morphology	mass	mass of connective tissue	1.41E-05	Increased	2.211	 	1.630	SCD,APOE,IGFBP4,TFEB,PLIN1,LEP,GDF15,BAG3,ADIPOQ,PNRC2,LIPA,G0S2,PCK2,CSPG4,PLIN2,DUSP10,UBL5,ATF4,GSK3B,SLC2A5,SRA1,SPP1,UCP2,FSTL3,NPY1R,TKT,SURF1,NR1H3,RAPGEF3,SOD1,PCK1,JUNB,CEBPB,NPY5R,FOSB,CISD1,IL1RN,SREBF1,DUSP1,APOC1,IGFBP3,ESR2	42	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of macrophages	1.42E-05	 	 	 	 	APOE,MSR1,PYCARD,GDF15,UNC5B,CXCL12,PPIA,IRAK1,LGMN,CSPG4,TGFB2,CYBB,CLCN3,PLAT,SIGMAR1,LCP1,SPP1,UCP2,TYROBP,TNFRSF1A,NPY1R,FCGR2A,EGR1,CAPG,CEBPB,CSF1R,GRN,FOS,MARCKSL1,CSF1,TREM2,FCER1G,CD14,PSAP,DUSP4,PLAU,SIRPA	37	
Infectious Diseases	productive infection	productive infection of cervical cancer cell lines	1.42E-05	Increased	3.920	bias	 	ALG14,TWF1,DAPK2,DPM1,BAG6,CD4,TECR,VPS4A,RAD23A,SSU72,TMEM132C,NDUFS6,LOC102724428/SIK1,MGAT1,ADAMTS5,KLF2,S100A1,SEC61G,MECOM,DTX4,MED20,GM2A,DVL1,AASS,SLC4A7,POLR2K,THAP11,PCK1,LRRC8D,STT3A,UTY,NRBP1,PDIA6,BRINP2,NDUFA6,STIP1,NDUFB7,PANK3,CYCS,ATOX1,GABARAP,UQCRC1,UBE2E1,MMP9	44	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of cancer cells	1.42E-05	 	1.724	 	0.399	EEF1A1,ICMT,NPM1,SOCS3,HRAS,DIRAS1,MKI67,GPC3,ODC1,SAE1,PEG10,PLCE1,CCND3,CTSS,GSK3B,RET,AHCY,PFKFB3,SPP1,LAIR1,HDAC2,PYGO2,BCL2L1,ADCYAP1R1,BSG,DUSP1,IL1RN,BTG2,IGFBP3,CTSB,SFRP1,SQSTM1,CYR61,AKR1B1,ESR2,ALK,CD151,LITAF,FHL1,SFRP2,LEP,DDIT3,GDF15,ADIPOQ,PROX1,RUVBL1,HIF1A,TAX1BP3,NELFE,THBS1,MCAM,FBXW11,TGFB2,KIT,RHOBTB2,PRKCE,ACVR1C,PLAT,COX17,TP63,EGR1,LZTS2,FGF1,GRN,FOS,CSF1,NR4A1,MMP9	68	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of phagocytes	1.45E-05	Increased	3.126	bias	0.502	NAB2,NPM1,PLCB2,CTGF,CTSG,CXCL12,NARS,CTSS,ABCC1,ITGAV,CYBB,STAB1,TXN,SPP1,ANXA2,NINJ1,CDC42,IL1RN,MS4A4A,SH2B3,RTN4,IL10RA,ALCAM,ADCYAP1,SIRPA,APOE,ADAM17,MMP14,ADIPOQ,HIF1A,FAS,FLNA,SAA1,MCAM,ANXA1,KIT,MAPKAPK2,PRNP,CD209,VCAM1,TNFRSF1A,TYROBP,MGAT5,PVR,PLXND1,CSF1R,APP,ITGB2,TNFAIP8L2,DOCK8,CSF1,TREM2,PLAU,MMP9	54	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of antigen presenting cells	1.50E-05	 	-0.632	 	-1.615	PTX3,APOE,SPP1,PFN1,TYROBP,CXCL12,FGFR2,SOD1,FAS,FGF1,GRN,CD28,HMOX1,TNFAIP8L2,THBS1,DOCK8,CSF1,IL1RN,NR4A1,PLAU,C6,PLAT	22	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of sphingolipid	1.52E-05	Increased	2.519	bias	0.652	SCD,LEP,ADIPOQ,UGCG,HEXA,FAS,CERS2,SGPL1,GBA,GLB1,ABCC1,KIT,NSMAF,CLN6,SMPD3,GM2A,ST6GALNAC3,ELOVL1,ARSA,SMPD2,SPTLC3,DEGS1,APP,SERINC2,BCL2L1,PPT1,MAPK10,PSAP,B3GNT5,ADCYAP1	30	
Skeletal and Muscular System Development and Function, Tissue Development	growth	growth of smooth muscle	1.53E-05	Increased	2.274	 	1.090	SOCS3,CMA1,CXCL12,MNAT1,SLC9A1,CAMK2D,COMT,TXN,GSK3B,AIF1,CALCRL,SPP1,CDK6,FGFR2,NPY5R,KLF4,IL1RN,IGFBP3,CAPN2,AKR1B1,TFPI,ESR2,C3AR1,SIRPA,IGFBP4,APOE,FHL1,LEP,NQO2,MMP14,ADIPOQ,PPIA,HIF1A,IRAK1,SHC1,HMOX1,CCDC88A,THBS1,STIM1,NFE2L2,PLAT,TNFRSF1A,EGR1,NQO1,ALOX5AP,HSPD1,CYP1B1,CXCL16,FOS,TNFAIP8L2,LPAR1,NR4A1,SOX9,PLAU,MMP9	55	
Cancer, Organismal Injury and Abnormalities	solid tumor	stage 4 solid tumor	1.55E-05	 	-0.714	 	-0.834	EEF1A1,NID2,PPIA,FKBP1A,RNASE1,RPS11,FAS,POR,HSP90AB1,CSE1L,ERBB4,TOP2A,TGFB2,IFI30,LOC102724428/SIK1,KIT,RNH1,TUBA1C,RET,CLCN3,TMSB10/TMSB4X,MYL12A,SEC61G,NDUFB4,SPP1,HDAC2,TUBB4B,TUBG1,TUBB2A,CDK6,SLC12A7,FGFR2,CSF1R,HAX1,ATIC,SERPINE2,FTL,IL1RN,EIF4A1,ALK,POLE3	41	
Cell Death and Survival	cell death	cell death of myeloid cells	1.57E-05	 	1.037	 	0.844	APOE,ADAM17,LEP,DDIT3,MSR1,PYCARD,NQO2,RAN,CXCL12,LGALS9,C1QA,HIF1A,FAS,IRAK1,HMOX1,LYZ,LTF,ANXA1,CYBB,PRKCE,GSK3B,NFE2L2,PLAT,TNFRSF1A,NQO1,CEBPB,HAX1,TPSAB1/TPSB2,APP,FOS,ITGB2,BCL2L1,IL1RN,CSF1,FCER1G,NR4A1,CTSB,CD14,MAP2K3,PIK3AP1,IRF8,C3AR1,SIRPA	43	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal tumor	intestinal tumor	1.58E-05	 	-0.083	bias	0.794	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,GLB1,DEFB132,GNA13,DCAF12,SYT17,SRPRA,ANXA2,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,PYGB,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,CCAR2,RUVBL1,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CCDC68,CD209,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,AOX1,NCAM1,CLUH,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PLCE1,DPP3,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRPL17,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,SIGMAR1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,DGAT2,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,ADRA1A,BZW2,NCDN,TMEM8A,SLC41A3,NTMT1,ACO2,BAG3,NME2,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,PACS2,HOXA10,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,PRMT5,P2RY12,MAPRE3,MVD,GAB2,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,HSPA13,STXBP5,PHF1,AKR1B1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,CENPV,C10orf71,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,RAN,GYG2,GHITM,MKI67,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,FARSA,NGRN,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,CDH11,ENAH,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,SLC48A1,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,GSPT1,CAMK2D,SLC25A6,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,DHX32,MDH2,BCKDK,DSP,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,RRAGD,ERBB4,HSPE1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,C2orf88,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,NEXN,PLEKHM2,MNAT1,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,TIMM8B,FLOT1,FGFR2,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,HSPA2,FOS,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,DOPEY2,MBD3,ABCC3,SIGLEC6,CSTF3,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,SLC24A2,RAB32,ADAM17,MSC,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,B4GALT2,FIS1,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,UTP4,TAF10,MMRN1,TUBB,VDAC2,NR2F1,RAB11FIP2,CTBP1,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,RAB10,CDK6,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,SOX17,TACR1,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,SLC27A3,MAT2A,USP9Y,RTN3	1023	
Cancer, Organismal Injury and Abnormalities	metastatic adenocarcinoma	metastatic adenocarcinoma	1.59E-05	 	 	 	 	S100A11,SCD,TUBB4B,TUBG1,TUBB2A,CDK6,FKBP1A,FGFR2,HIF1A,CSF1R,ATIC,FAS,PTPRC,BCL2L1,ERBB4,EIF4A1,KIT,TUBA1C,SFRP1,RET,ABCC3,POLE3,ALK	23	
Cancer, Neurological Disease, Organismal Injury and Abnormalities	gliomatosis	gliomatosis	1.61E-05	 	0.105	 	-0.292	NPM1,ADAMTS8,LDB3,CA12,HRAS,MKI67,MUC7,CLIP1,PRG4,EIF4G2,MCOLN3,MGAT4B,ALDOC,LCP1,SV2B,FAM126B,FGFR2,HSPA8,PYGO2,CCND2,CD300C,MS4A7,ARHGAP35,ALCAM,SFRP1,SETBP1,CDH18,GSTM5,GBP1,HLA-A,BAG6,ARL4C,HMGN1,GDF15,HYOU1,FKBP1A,H2AFZ,TOP2A,PRKCE,MYO1D,ALPK2,PLXNA1,CD209,SLC25A13,MECOM,TNFRSF1A,IMPDH2,SPTLC3,HSPA2,GRN,SNTG2,COL5A3,KIF7,NTRK3,FLNC,BMF,PRMT5,SOX9,AOX1,PLAU,ABCC3,BMP6,NCAM1,NAB2,VAMP5,MBP,SCN7A,BAG3,TMEM147,CXCL12,DIRAS1,HSPA5,BIN1,HS6ST1,LYNX1,RPL21,FAR2,ITGAV,ANXA7,GOT1,GSK3B,RET,ADAMTS5,PTX3,PFKFB3,TRIOBP,SPP1,HDAC2,YWHAB,TNPO1,ATP6V1A,DMXL2,BCL2L1,PPP2R1A,CLCN7,UHRF1BP1L,SIRPA,MSR1,ATF5,MMP14,PKM,CFTR,HIF1A,MLH1,FAS,CLCN4,SOX17,HLA-G,COL6A1,PREPL,CSPG4,THBS1,FLNA,DKK3,KCNMA1,ANXA1,ERBB4,TGFB2,KIT,CYGB,NR2F6,ACTN1,SEC61G,VCAM1,AKR1C1/AKR1C2,RARS2,VANGL1,RNF43,MAP3K1,SYNPO2,CSF1R,ANO2,FGF1,CXCL16,SHB,LPAR1,MUC17,C6,MAP4K4,MMP9	140	
Cancer, Organismal Injury and Abnormalities	lymphoreticular neoplasm	lymphoreticular neoplasm	1.71E-05	 	-1.867	bias	-0.247	NPM1,KLHDC8B,WHSC1,PCLO,RRM2B,RAN,MKI67,ODC1,CECR1,POR,PTPRC,GNB1,BCAT1,ZBTB7B,CCND3,CSE1L,RPS2,GNA13,UNG,TUBB2A,FGFR2,JUNB,HMGA1,ROR1,KIAA0100,CD52,CCND2,BTG2,CCT3,DUSP4,CYR61,STEAP3,ALK,MSC,PRDX1,LRP6,FKBP1A,SMARCA4,RPL35,MYO5C,TOP2A,FKBP3,SIGMAR1,PTPRK,IMPDH2,FCGR2A,TUBB4B,EGR1,LZTS2,IPO7,STXBP6,CYP1B1,MTHFD1L,ALDH1L2,BMF,USP22,PRMT5,CCT7,CBX4,CSTF3,ADRA1A,NCAM1,UBE2A,CXCL12,VDAC2,NNMT,PAX5,NARS,SAE1,RPL13,RPS13,ANXA7,TUBA1C,GSK3B,RET,DSP,EIF2AK1,PSMB5,HDAC2,UROS,CDK6,HIST1H2BK,BCL2L1,XRCC6,SH2B3,IGFBP3,LFNG,IRF8,TFPI,PPAT,POLE3,IGFBP4,SRPX,RBBP8,HIF1A,ALAS1,MLH1,FAS,IRAK1,MPEG1,THBS1,ANXA1,MCAM,KIT,KLHL42,LONP1,ADAMTS15,TP63,TPST2,TUBG1,NQO1,GABBR1,CEBPB,ATIC,CXCL16,SLC33A1,PSMD2,SLC16A1,PAG1,UQCRC1,MAP4K4,MMP9,ATP6V1B2,SHMT2	124	
Infectious Diseases	infection	infection of cells	1.75E-05	Increased	8.361	bias	 	TWF1,RAB5C,HRAS,RAD23A,GATAD2A,LTF,CTSS,ETF1,CHCHD2,LSM3,MGAT1,CAPN6,AASS,ANXA2,PCK1,COPB1,NRBP1,TMEM127,BSG,STIP1,BTG2,NDUFB7,PSMA5,ATMIN,CTSB,TFRC,ATOX1,APOE,LAPTM5,ATP6V0B,ARPC1B,DAPK2,BAG6,LGALS9,PFKL,ATRAID,TECR,ACTR3,FBXW11,SERPINA1,SNRPD3,RPL18,PLOD3,S100A1,PLOD2,CD209,ANKRD9,MECOM,DTX4,MED20,FGD6,SPATS2L,THAP11,PVR,PSMB6,LRRC8D,COPG1,APP,EIF3G,PDIA6,NTRK3,CSF1,BRINP2,GCSH,CYCS,GABARAP,SDF4,SLC31A1,ARF1,CD4,DPM1,RACK1,CXCL12,AP1B1,HSPA5,CTBP1,CD28,TMEM132C,NDUFS6,CYBB,STAB1,MID1IP1,UQCRFS1,SNU13,C1QBP,ADAMTS5,KLF2,STXBP1,CYB5B,GM2A,MAPK8IP2,HSPA9,CLTC,PSMC4,SLC4A7,RPL12,POLR2K,AES,CDC42,NDUFA6,ATP6V0D1,RARRES3,UBE2E1,UTP11,ALG14,ZC3H7B,ATP6V0C,PPIB,GANAB,HNRNPK,VPS4A,FAS,SSU72,MED15,LOC102724428/SIK1,RNH1,PSMA3,HMGCS1,PRNP,NDUFAF3,SLC20A1,SEC61G,DLGAP4,TRIM55,DVL1,R3HDM1,EXOSC5,FAU,STT3A,UTY,PANK3,MAT2A,UQCRC1,RTN3,MMP9	135	
Lipid Metabolism, Small Molecule Biochemistry	catabolism	catabolism of sphingolipid	1.75E-05	Increased	2.396	bias	 	SGPL1,GBA,GLB1,GM2A,PPT1,PSAP,HEXA,ARSA,SMPD2,SMPD3	10	
Cellular Function and Maintenance	engulfment	engulfment of blood cells	1.78E-05	Increased	3.874	bias	1.474	APOE,GAB2,NPM1,MSR1,HYOU1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,GULP1,EIF2AK1,PTX3,CD209,CALR,SRA1,UCP2,FCGR2A,RAPGEF3,CAPG,PGAP3,CEBPB,APP,ITGB2,CDC42,TREM2,FCER1G,CD14,IRF8,PLAU,SIRPA	37	
Cellular Development, Tissue Development	differentiation	differentiation of bone cells	1.81E-05	 	-0.248	 	-1.013	GAB2,SOCS3,RACK1,GPC3,RPS11,GPR55,DYNLL1,LTF,HOXA10,ATF4,GSK3B,WNT5B,SPP1,FSTL3,CLTC,ERH,CDK6,FGFR2,RAPGEF3,JUNB,CITED1,BCAP29,KLF4,OSTM1,INPP4B,PRKACA,TFRC,MAP2K3,LRP8,SFRP1,SQSTM1,CYR61,C3AR1,SIRPA,DDX21,APOE,LEP,SFRP2,SLC1A5,MMP14,BAG6,ADIPOQ,LGALS9,HIF1A,ATRAID,ATP6AP1,FAS,COL6A1,PHB,EFNB1,HSPE1,TGFB2,SNX10,LY6E,HCST,IARS,ALPL,TP63,TYROBP,GABBR1,SOD1,CEBPB,CSF1R,FOS,RPS15,CAPNS1,MYOC,LPAR1,CSF1,TREM2,FCER1G,BMPER,BMP6,ID4	74	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development	cell proliferation	cell proliferation of fibroblasts	1.82E-05	 	1.014	bias	-1.084	ICMT,NPM1,SOCS3,SLC7A11,CTGF,HRAS,NCSTN,SGPL1,CTSD,HS6ST1,PLCE1,LTF,CCND3,NUPR1,IFI30,ATF4,TXN,AIF1,DKC1,CDK6,ANXA2,FOSB,TLN2,CCND2,DUSP1,IGFBP3,CTSB,MAP2K3,GNL3,DUSP4,SFRP1,GSTP1,PPAT,FTH1,SULF1,IGFBP4,GEM,PDGFA,HMGN1,ADIPOQ,HIF1A,SP2,MLH1,FAS,HMOX1,OGT,HINT1,DKK3,TGFB2,NDUFS4,PLAT,TNFRSF1A,ACTB,MAP3K1,EMD,SOD1,CEBPB,PSME3,CSF1R,FGF1,GRN,FOS,LPAR1,CSF1,PLAU,MMP9	66	
Immunological Disease	hypersensitive reaction	hypersensitive reaction	1.87E-05	 	1.788	 	0.546	EEF1A1,GAB2,PLIN1,PLP1,CD4,MBP,GARS,MKI67,STARD7,CD63,VDAC2,NR2F1,PTPRC,CD28,PTGES2,LGMN,ALDH3A2,IFI30,AHCY,TRIOBP,SPP1,CFL1,CNR1,TPM3,FLOT1,CAPG,JUNB,MYL9,BCL2L1,ADRA2A,IL1RN,DUSP1,XRCC6,ALCAM,PHF1,C3AR1,UBE2I,S100A11,APOE,SRM,ADAM17,LAPTM5,PYCARD,HLA-A,HN1,PCDHGB4,ADIPOQ,PPIA,FKBP1A,RUVBL1,CD83,H2AFZ,FLNA,ANXA1,MCAM,ANXA5,DUSP10,KIT,STIM1,HPGDS,P4HA2,CALR,CAPZB,TNFRSF1A,NPY1R,FCGR2A,ALOX5AP,SOD1,CEBPB,NFKBIZ,IL20RB,ITGB2,ENO1,FCER1G,FKBP4,PSAP,MMP9,ADRA1A	78	
Inflammatory Response	immune response	immune response of cells	2.00E-05	Increased	4.681	bias	1.940	NPM1,CTSG,C1QA,CLIP1,SPRY4,PTPRC,LTF,CTSS,ABR,GNA13,LAIR1,ROR1,HSPA8,CD68,IL10RA,CTSB,GAPDH,ADCYAP1,C3AR1,ALK,APOE,RALA,HLA-A,SLC1A5,ADIPOQ,LGALS9,MMP25,G6PC3,ARF6,ANXA5,TOP2A,PRKCE,TUB,STIM1,HPGDS,PLXNA1,UCP2,FCGR2A,TNFRSF1A,TYROBP,GNA12,OTUB2,CYP1B1,APP,ITGB2,DOCK8,CSF1,TREM2,FCER1G,PLAU,GAB2,SOCS3,TRAF3,PLP1,PFN1,CD4,RACK1,BIN1,CD28,CTSD,RHOG,ITGAV,CLCN3,RET,KLF2,GULP1,EIF2AK1,PTX3,TNPO1,CLTC,RAPGEF3,PGAP3,CAPG,MLST8,CMC2,BCL2L1,CDC42,MAPT,CD14,IRF8,SIRPA,LITAF,LEP,MSR1,PYCARD,CD83,FAS,IRAK1,HMOX1,THBS1,SAA1,ANXA1,GSTM4,MAPKAPK2,PRNP,CALR,VCAM1,TRIM55,CLEC9A,CEBPB,ASAP2	101	
Cancer	transformation	cell transformation	2.03E-05	Increased	3.464	bias	0.751	ICMT,NPM1,GAB2,TRAF3,PTPN23,SEPT9,CD4,MAF,HRAS,DIRAS1,BIN1,ODC1,DYNLL1,RHOG,CCND3,GNA13,RET,SPP1,CLTC,CDK6,FGFR2,TPM3,THRA,JUNB,HMGA1,SLC3A2,FOSB,SH3GL1,BCL2L1,SDCBP,CCND2,CDC42,IL1RN,BTG2,GPR65,MAPK10,MAP2K3,SFRP1,CYR61,TMEM176B,ESR2,SIRPA,RPL41,FTH1,ALK,PEBP1,HTATIP2,TFEB,SFRP2,RPS3A,PDGFA,PRDX1,LGALS9,RUVBL1,EIF2S1,TACR1,SHC1,EFNB1,ERBB4,TGFB2,KIT,PRKCE,ADCY2,TP63,MECOM,EGR1,GNA12,DVL1,LZTS2,CEBPB,CSF1R,NDUFA13,ATIC,COPG1,FGF1,FOS,NTRK3,CSF1,PRMT5,SOX9,PPP2R1B,MMP9	82	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	transmigration	transmigration of monocytes	2.04E-05	Increased	2.918	bias	1.677	ADAM17,VCAM1,TNFRSF1A,MMP14,CXCL12,PVR,APP,ITGB2,CDC42,CTSS,MCAM,ITGAV,SIRPA,MMP9	14	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	lymphocytic cancer	lymphocytic cancer	2.12E-05	 	-1.867	bias	-0.181	NPM1,KLHDC8B,WHSC1,PCLO,RRM2B,RAN,MKI67,ODC1,POR,CECR1,PTPRC,GNB1,BCAT1,ZBTB7B,CCND3,CSE1L,RPS2,GNA13,UNG,TUBB2A,FGFR2,JUNB,HMGA1,ROR1,KIAA0100,CD52,CCND2,BTG2,CCT3,DUSP4,CYR61,STEAP3,ALK,MSC,PRDX1,LRP6,FKBP1A,SMARCA4,RPL35,MYO5C,TOP2A,FKBP3,SIGMAR1,PTPRK,IMPDH2,FCGR2A,TUBB4B,EGR1,IPO7,STXBP6,CYP1B1,MTHFD1L,ALDH1L2,BMF,USP22,PRMT5,CCT7,CBX4,CSTF3,ADRA1A,NCAM1,UBE2A,CXCL12,VDAC2,NNMT,PAX5,NARS,SAE1,RPL13,RPS13,ANXA7,TUBA1C,GSK3B,RET,DSP,EIF2AK1,PSMB5,HDAC2,UROS,CDK6,HIST1H2BK,BCL2L1,XRCC6,SH2B3,IGFBP3,LFNG,IRF8,TFPI,PPAT,POLE3,IGFBP4,SRPX,RBBP8,HIF1A,ALAS1,MLH1,FAS,IRAK1,MPEG1,THBS1,ANXA1,MCAM,KIT,KLHL42,LONP1,ADAMTS15,TP63,TPST2,TUBG1,NQO1,GABBR1,CEBPB,ATIC,CXCL16,SLC33A1,PSMD2,SLC16A1,PAG1,UQCRC1,MAP4K4,MMP9,ATP6V1B2,SHMT2	123	
Cellular Assembly and Organization, Cellular Compromise	formation	formation of cellular inclusion bodies	2.15E-05	 	0.420	 	-0.249	APOE,PSMC4,DNAJA4,SOD1,HSPA2,APP,UCHL1,BCL2L1,HSPA4,FTL,STUB1,MAPT,CTSB,TCP1,NAGLU,PSAP,SIAH2,SERPINA1,GSK3B,SQSTM1,ATP13A2,PRNP	22	
Cellular Function and Maintenance	engulfment	engulfment of phagocytes	2.15E-05	Increased	3.476	bias	1.300	GAB2,NPM1,MSR1,HYOU1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,EIF2AK1,PTX3,CD209,CALR,SRA1,UCP2,FCGR2A,CAPG,PGAP3,RAPGEF3,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,PLAU,SIRPA	33	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of cerebral cortex	2.20E-05	 	-0.245	 	0.110	APOE,MAPT,PPT1,ADIPOQ,CLCN7,ATP13A2,PRNP,APP,CERS2	9	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	urinary tract tumor	urinary tract tumor	2.21E-05	 	1.086	 	1.412	REM1,WHSC1,PCLO,VAC14,PLEKHM2,MNAT1,CLIP1,ODC1,NPL,POR,GNB1,EIF4G2,CCND3,GLB1,KEAP1,SPTB,DEFB132,GNA13,SLC2A5,LCP1,PPP1R1B,FGFR2,ANXA2,RCC2,BTG2,NDUFB7,GPR65,GCC1,ESR2,EPHX1,NME1,PSMD7,OSGIN1,BAG6,CUBN,EEF1B2,MFSD5,PROX1,SMARCA4,ACSS3,HSP90AB1,TNXB,ARFGAP1,PLIN2,ATP5J2,SERPINA1,ALPK2,NFE2L2,S100A1,PLOD2,SRA1,MECOM,TUBB4B,DGAT2,LZTS2,SNCG,FOS,AFF3,FLNC,DOPEY2,MBD3,PSAP,C6orf62,SOX9,BMP6,C11orf68,PCDH18,SESN2,SLC41A3,MBP,DIRAS1,GPC3,LHFPL2,HS6ST1,MEGF6,MOCOS,UQCRFS1,TUBA1C,BCAS2,STK39,RILPL1,LAMA2,KCNK2,SRPRB,GUF1,FOSB,BCL2L1,RPL8,SDCBP,DNAJC5,NDUFA6,IGFBP3,POLE3,CALHM2,PTGFR,SCD,SLC1A4,FAT3,PKHD1L1,ALAS1,HNRNPK,FILIP1,IRAK1,RPL14,PPP1R2,SAA1,LOC102724428/SIK1,LIAS,FAM171B,TP63,NPY1R,TUBG1,NQO1,HPS1,PYGB,ATIC,UTY,CXCL16,POLR3B,PSMD2,MUC17,SLC25A5,SLC29A4,LDB3,HRAS,MKI67,MUC7,PRG4,ZNF605,POU6F2,KIF21A,HADHB,BIRC7,CALCRL,NANOS1,CENPB,TUBB2A,DPY19L1,NINJ1,SH3GL1,CCND2,BSG,IL10RA,ADM2,ARHGAP35,CCT3,MAP2K3,SFRP1,AIDA,TCF7,CYR61,SETBP1,FH,GSTP1,PHLPP1,SLC4A4,S100A11,ADAM17,RALA,KLHL18,BTG3,HLA-A,DUSP6,FKBP1A,XPOT,ATP6AP1,UCHL1,CADM2,MT-CYB,ANXA5,TBC1D12,TOP2A,TRIM16,PRKCE,RPS12,GJB2,PLAT,CD53,CD209,PLXNA1,ACTB,ATXN2L,COL5A3,CLIC6,MRPL51,SREBF2,PPP1R16B,DOCK8,GABARAP,CXCL12,XPO5,TUBB,METAP2,GSPT1,COMT,SIAH2,RET,RAD51C,MFSD3,FERMT3,SLC6A8,ACSL3,TRIOBP,TBC1D2B,SPP1,POLR1A,ANLN,GCNT2,GPAA1,TPSAB1/TPSB2,PPP2R1A,IL1RN,TMOD1,RNPEP,RAB1A,PKM,CFTR,HIF1A,HMOX1,SLFN5,PCK2,CSPG4,FLNA,KCNMA1,THBS1,ERBB4,KIT,ASAP3,CACNG8,CALR,FRMD1,TMEM126B,ADCY2,TPST2,RARS2,AP3D1,PHLDA3,MAP3K1,NXPH4,ZBTB7C,GUK1,NFKBIZ,CSF1R,MT-ND5,LPAR1,GBE1,SLC47A1,MMP9	248	
Cellular Movement	cell movement	cell movement of neuroglia	2.23E-05	 	1.748	bias	0.293	NAB2,NPM1,CTGF,PDGFA,LAMA2,CXCL12,HRAS,CSF1R,NDN,APP,GBA,CDC42,MATN2,CSPG4,TGFB2,ITGAV,CYBB,TSPO,P2RY12,CHI3L1,MMP9,PRNP,NCAM1	23	
Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of cellular protrusions	2.26E-05	Increased	3.226	bias	-0.551	CTGF,HRAS,SLC9A1,BBS1,DYNLL1,DGKG,PRKY,GNA13,TESK1,LCP1,RIMS3,CFL1,CNR1,FGFR2,TPM3,FLOT1,ROR1,NDN,NINJ1,BSG,FSCN1,STIP1,BTG2,PRKACA,ATMIN,RTN4,LRP8,CYR61,ADCYAP1,APOE,NME1,RALA,PLXNA3,BTG3,CDK16,GDF15,ADIPOQ,SDC3,DCLK1,SDK1,ENAH,UCHL1,CETN2,ARF6,ACTR3,UST,RHOD,SRGAP1,SNX10,ACAP2,PRKCE,NPTXR,PLAT,IL11RA,PTPRK,TNFRSF1A,ACTB,EGR1,GNA12,PVR,ARL3,CPEB4,APP,GRN,MYO5A,FOS,MYOC,NTRK3,CSF1,TENM4,SREBF1,ADCY1,ARAP1,ATXN10,P2RY12,PLAU,BMP6,RUFY3,NCAM1,EEF1A1,NCDN,PFN1,PTPN23,MBP,MAP1B,CXCL12,SDC4,DYNLT1,NNMT,RHOG,NEO1,CDC42EP1,GSK3B,C1QBP,RET,FERMT3,HDAC2,MAPK8IP2,CNP,RAB10,CAPG,SMPD2,TXNRD1,CDC42,MATN2,MAPT,NUAK1,CAPN2,UHMK1,STXBP5,SIRPA,SULF1,GEM,RNF165,LEP,EPB41L3,PDGFA,VAPA,FLRT1,UGCG,HNRNPK,PHLDB2,TNFRSF12A,SHC1,CCDC88A,TWF2,THBS1,FLNA,DKK3,EFNB1,ERBB4,KIT,MICALL1,NSMF,DNAAF1,SHANK2,MAPKAPK2,PI4KB,LASP1,PRNP,SEMA3E,CAPZB,DVL1,MAP3K1,SOD1,KIF3B,FGF1,CAPNS1,LPAR1,KIF5B,TTL,EPHB3,TBC1D7,RTN3	154	
Cellular Function and Maintenance	engulfment	engulfment of leukocytes	2.35E-05	Increased	3.868	bias	1.454	APOE,GAB2,NPM1,MSR1,HYOU1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,EIF2AK1,PTX3,CD209,CALR,SRA1,UCP2,FCGR2A,RAPGEF3,CAPG,PGAP3,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,IRF8,PLAU,SIRPA	35	
Cell Death and Survival, Neurological Disease	cell death	cell death of brain cells	2.36E-05	 	-0.104	 	0.050	MAP1B,CXCL12,SH3GLB1,HSPA5,CTSD,GCLM,GSK3B,UNG,YWHAB,CDK6,JUNB,BCL2L1,ADAM12,DUSP1,IL1RN,CDC42,STIP1,MAPT,MAPK10,GAPDH,MAP2K3,ADCYAP1,APOE,LEP,DDIT3,UBQLN1,VAPA,HYOU1,HIF1A,FAS,PARK7,GBA,TCP1,RPS3,NFE2L2,ATP13A2,PRNP,PLAT,SRR,UCP2,TP63,TNFRSF1A,EGR1,MAP3K1,SOD1,HSPD1,APP,FOS,CAPNS1,NTRK3,PEA15,CYCS	52	
Protein Synthesis	polymerization	polymerization of protein	2.38E-05	 	1.577	bias	 	EEF1A1,NPM1,GFPT1,PFN1,SEPT9,NME2,CXCL12,HRAS,SH3GLB1,TAF10,CAMK2D,CHMP2A,KEAP1,MID1IP1,MTMR2,CDC42EP1,TMSB4Y,ALDOC,UXS1,YWHAB,AASS,STOML2,FLOT1,ANXA2,TXNRD1,MICU1,SCUBE1,CDC42,XRCC6,GLUL,SQSTM1,PCBD1,PPAT,CTNNA1,ADIPOQ,PFKL,ME1,FAS,IRAK1,ENAH,C1QTNF3,HMOX1,NAXE,KCNMA1,DCXR,ANXA5,TRABD2A,NACC1,LONP1,AMFR,RPS19,OAS1,SRR,AKR1C1/AKR1C2,TP63,TNFRSF1A,IMPDH2,TRIM28,MAP3K1,TRPA1,APP,FIS1,KCTD13,CSF1,LIMS1,DERL1,IVD,MMP9,SHMT2	69	
Reproductive System Development and Function	fertility	fertility	2.47E-05	Increased	4.644	bias	 	NR6A1,APOB,UBE2A,MMEL1,MAP1B,SLC35C1,APRT,HOXA10,ATF4,CLCN3,PTX3,HDAC2,STK39,CENPB,TKT,TALDO1,MAPK8IP2,SURF1,CDK6,NR1H3,THRA,ADCYAP1R1,MRNIP,IL1RN,PRKACA,H1F0,B3GNT5,PLTP,ADCYAP1,TMOD1,TNS1,ESR2,PAFAH1B2,SULF1,LEP,SCARA5,CFTR,G6PC3,STUB1,FLNA,THBS1,KIT,PRKCE,NACC1,HCST,RAD23B,PRNP,IL11RA,PLAT,TPST2,SLC6A6,F13A1,GABBR1,SOD1,CEBPB,CSF1R,APP,WIPF3,APLP2,CLGN,FCER1G,FKBP4,ARHGDIA,PLAU,CPEB1,MMP9,FHL5	67	
Skeletal and Muscular System Development and Function	function	function of muscle	2.49E-05	 	1.144	bias	-1.453	GAB2,PFKFB1,MRVI1,AK1,PLCE1,GAA,PLIN5,FST,SPP1,SGCG,FSTL3,LAMA2,CNP,NR1H3,RAPGEF3,THRA,JUNB,DES,COX7A1,MTPN,DNAJC5,CDC42,DUSP1,IGFBP3,ESR2,SORL1,SULF1,IGFBP4,APOE,LEP,HLA-A,MMP14,DUSP6,GDF15,ADIPOQ,HSPB8,FKBP1A,SHC1,HMOX1,THBS1,KCNMA1,EFNB1,PRKCE,PLAT,PRNP,MYH1,S100A1,TRIM55,SLC6A6,MAP3K1,SOD1,CEBPB,POMGNT1,ENO1,MARCKSL1,LAMP2,LIMS1,FLNC,NR4A1,NUCB2,GBE1,PLAU,SGCD,MMP9	64	
Organismal Development	growth	growth of organism	2.54E-05	Increased	4.676	bias	1.830	RRM2B,RAN,HRAS,SLC35C1,SGPL1,GATAD2A,PTP4A2,CCND3,LTF,GLB1,CSE1L,ABCC1,STAM,TXN,AIF1,GNA13,MGAT1,LCP1,CFL1,TKT,CNR1,FGFR2,PCK1,NDN,PLAG1,YARS,PRKACA,CTSB,TFRC,MAP2K3,ATOX1,AARS,ADCYAP1,APOE,USP18,SLC4A2,HLA-A,LRP6,CTNNA1,SP2,SMARCA4,G6PC3,MAFG,LYZ,HSP90AB1,STIM1,CSNK2B,IL11RA,MYH1,UCP2,TNFRSF1A,GNA12,LZTS2,TIAL1,APP,MRAP,MYOC,NTRK3,LIMS1,CSF1,EIF4A1,SOX9,BMP6,ID4,NCAM1,HOXB5,ICMT,PNO1,GAB2,SOCS3,SLC31A1,PRPF19,VPS28,MAP1B,RACK1,CXCL12,TAF10,HSPA5,GPC3,METAP2,CTSD,SLC25A6,RHOG,CDON,NDUFS6,MID1IP1,ANXA7,GSK3B,RET,KLF2,SPP1,LAMA2,PSMC4,CDK6,POLR2K,THRA,CITED1,KLF4,TXNRD1,SEL1L,AES,CDC42,IL1RN,MAPT,IGFBP3,TFPI,UBE2I,ATP6V0C,ALG14,IGFBP4,LEP,F2RL3,ATF5,PDGFA,MECR,RBBP8,HIF1A,MLH1,HMOX1,KCNMA1,EFNB1,KIT,HSD11B2,MAPKAPK2,LIAS,STK40,RAD23B,PRNP,TP63,TPST2,TUBG1,MAP3K1,GABBR1,PSME3,FGF1,LPAR1,SLC33A1,KIF5B,SLC25A5,HLTF,MMP9	141	
Carbohydrate Metabolism	metabolism	metabolism of monosaccharide	2.57E-05	 	0.271	bias	-0.609	HK1,APOE,ANGPTL8,PFKFB3,GNPDA1,OAS1,GFPT1,LEP,PFKFB1,NPY1R,FUCA2,PKM,TALDO1,ADIPOQ,PFKL,PCK1,G6PC3,APP,TACR1,CD28,FUOM,GLB1,SREBF1,DCXR,ALDOA,GSK3B,ALDOC	27	
Connective Tissue Development and Function, Tissue Morphology	mass	mass of adipose tissue	2.57E-05	Increased	2.537	 	1.865	SCD,APOE,IGFBP4,PLIN1,LEP,GDF15,BAG3,ADIPOQ,PNRC2,LIPA,G0S2,PCK2,CSPG4,PLIN2,DUSP10,UBL5,ATF4,GSK3B,SLC2A5,SRA1,UCP2,FSTL3,NPY1R,TKT,SURF1,NR1H3,RAPGEF3,PCK1,JUNB,CEBPB,NPY5R,FOSB,CISD1,SREBF1,DUSP1,IL1RN,APOC1,IGFBP3,ESR2	39	
Free Radical Scavenging	generation	generation of reactive oxygen species	2.60E-05	 	0.245	 	-0.784	SOCS3,LEP,MMP14,ADIPOQ,PPIA,HRAS,RPL26,FAS,SCO2,CD28,HMOX1,LTF,CXCL14,CYBB,UQCRFS1,TPO,CLCN3,OGDH,NFE2L2,VCAM1,UCP2,FCGR2A,RPL29,SDHC,THRA,SOD1,CSTB,CYP1B1,TXNRD1,APP,FOS,BCL2L1,TNFAIP8L2,SREBF2,CDC42,SREBF1,MAP2K3,GABARAP,PLAU,AKR1B1,C3AR1,GSTP1	42	
Immunological Disease	systemic autoimmune syndrome	systemic autoimmune syndrome	2.61E-05	 	1.658	 	1.428	C9orf72,MMEL1,CTSG,C1QA,CLSTN2,MNAT1,EEF1G,PTPRC,CECR1,DYNLL1,IP6K3,CCND3,LTF,CTSS,GAA,PXK,POU6F2,CHCHD2,TXN,AIF1,LCP1,CALCRL,NR1H3,FLOT1,CD52,C1orf162,HSPA8,TMEM127,CTSA,SCUBE1,CD68,CNTNAP4,CD300C,GPR65,MS4A7,IL10RA,CTSB,ALDOA,TFRC,GLUL,LRP8,TCF7,C3AR1,FTH1,SORL1,APOE,HLA-A,PRDX1,BAG6,HSPB8,ADIPOQ,ST6GALNAC4,FKBP1A,GPC4,SDC3,CDH11,ENAH,LYZ,TNXB,LY6E,FKBP5,ALPK2,RPL31,MYL12A,RPS24,OAS1,UCP2,TYROBP,TNFRSF1A,IMPDH2,FCGR2A,TRIM28,ALOX5AP,AGPAT1,SPATS2L,GRN,FOS,ITGB2,RPS16,CSF1,FCER1G,NR4A1,C6orf48,TSPO,SGCD,SOCS3,SLC7A11,ARF1,PRMT3,CD4,CXCL12,SDC4,TUBB,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,CYBB,RET,COL27A1,RPL32,SPP1,DNASE2,HDAC2,LMO4,ERH,CDK6,RAB10,CAPG,PPP1R11,SLC3A2,FOSB,SEL1L,BCL2L1,CD3G,DUSP1,IL1RN,SH2B3,SLC7A2,NAGLU,PLEK,PPAT,RPSA,CD151,PTGFR,SCD,IGFBP4,LEP,PRDX5,SLC7A1,CD83,GANAB,FAS,NELFE,MPEG1,EVC,HLA-G,HMOX1,SLFN5,RPL18A,CCSER2,THBS1,DKK3,ANXA1,EFNB1,SAA1,TGFB2,HCST,RPS3,ALPL,PRNP,CALR,VCAM1,AGFG1,HPS1,CLEC9A,GABBR1,VSIG4,HSPD1,CEBPB,ATIC,FAU,CXCL16,ENO1,APLP2,ITPA,DIP2C,SGF29,CHI3L1,MAP4K4,MMP9	175	
Post-Translational Modification, Protein Degradation	oxidation	oxidation of protein	2.68E-05	 	-1.602	 	-0.894	APOE,HSPA4,HMOX1,FTL,PARK7,CYBB,TXN,NFE2L2,FTH1,APP	10	
Cell Death and Survival	cell death	cell death of carcinoma cell lines	2.73E-05	 	-0.188	 	-0.001	SLC7A11,PFKFB1,ACO2,CXCL12,DNAJC15,GPC3,HSPA5,CDON,ABCC1,KEAP1,ITGAV,UQCRFS1,GSK3B,RET,ZBTB16,KLF2,HK1,IGFBP6,SPP1,PPP1R1B,FGFR2,HMGA1,TXNRD1,BCL2L1,CCND2,DUSP1,IGFBP3,CTSB,GAPDH,SFRP1,SULF1,SCD,ADAM17,HTATIP2,DDIT3,OSGIN1,PKM,ADIPOQ,CCAR2,HIF1A,EIF2S1,FAS,UCHL1,HMOX1,OGT,PRKCE,STIM1,SEMA3B,HCST,TP63,NQO1,SOD1,APP,GRN,PEA15	55	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	cell death	cell death of kidney cell lines	2.73E-05	 	1.145	 	-0.219	UNC5B,HRAS,HSPA5,SGPL1,RHOG,CDON,MCOLN3,ABCC1,ITGAV,NEO1,GSK3B,GNA13,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,VDAC1,GSTP1,GSTM5,DDIT3,PYCARD,LRP6,HYOU1,FAS,STUB1,ERBB4,AAK1,NFE2L2,GMFB,ATP13A2,TMEM123,PRNP,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,APP,FGF1,EMP1,FOS,MYOC,TNFAIP8L2,NTRK3,SREBF2,PEA15,CYCS,SLC47A1	57	
Cellular Movement	cell movement	cell movement of glioma cells	2.80E-05	Increased	2.201	bias	1.175	GAB2,CTGF,SFRP2,SPP1,THBS1,TGFB2,CTSB,CXCL12,PRKCE,SFRP1,SMARCA4	11	
Cellular Movement	migration	migration of tumor cells	2.82E-05	Increased	3.916	bias	2.012	GAB2,CTGF,LEP,SFRP2,MMP14,ADIPOQ,CXCL12,HRAS,PROX1,SMARCA4,THBS1,CSE1L,MCAM,TGFB2,HOXA7,PRKCE,RHOBTB2,SIAH2,RET,CLCN3,ZBTB16,AHCY,BIRC7,VCAM1,TP63,SPP1,GNA12,MAP3K1,RAPGEF3,CSF1R,KLF4,TNFAIP8L2,CDC42,CSF1,DUSP1,CTSB,ALCAM,SFRP1,PLAU,TFPI,ESR2,SIRPA,MMP9,CD151	44	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of smooth muscle cells	2.83E-05	Increased	2.408	 	1.198	SOCS3,CMA1,CXCL12,MNAT1,SLC9A1,CAMK2D,COMT,TXN,GSK3B,AIF1,CALCRL,SPP1,CDK6,FGFR2,NPY5R,KLF4,IL1RN,IGFBP3,CAPN2,AKR1B1,TFPI,ESR2,C3AR1,SIRPA,IGFBP4,APOE,FHL1,LEP,NQO2,MMP14,ADIPOQ,PPIA,HIF1A,IRAK1,SHC1,HMOX1,CCDC88A,THBS1,STIM1,NFE2L2,PLAT,TNFRSF1A,EGR1,NQO1,ALOX5AP,HSPD1,CYP1B1,CXCL16,FOS,TNFAIP8L2,LPAR1,NR4A1,PLAU,MMP9	54	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of phospholipid	2.85E-05	Increased	2.434	 	1.547	ABHD12,EEF1A1,SCD,APOE,LEP,ARF1,VAC14,HRAS,UGCG,CFTR,HIF1A,FAS,SLC27A4,CERS2,ARF6,HINT1,GLB1,ANXA5,SAA1,ABCB11,PI4KB,SPP1,CYP27A1,DGAT2,NR1H3,STOML2,FIG4,ELOVL1,SMPD2,NRBF2,THRSP,SLC3A2,APP,DGKQ,CSF1,SREBF1,FCER1G,CD14,PLTP	39	
Cellular Movement	transmigration	transmigration of cells	2.86E-05	Increased	3.608	bias	1.603	APOE,ADAM17,MMP14,GDF15,CXCL12,HRAS,ENAH,CD28,LIPA,SHC1,CTSS,MCAM,ITGAV,STAB1,SIAH2,FERMT3,CD209,VCAM1,SPP1,TNFRSF1A,KCNK2,PVR,NINJ1,APP,ITGB2,CDC42,CSF1,DOCK8,RTN4,ALCAM,CAPN2,SIRPA,MMP9,CD151	34	
Cancer, Organismal Injury and Abnormalities	metastatic potential	metastatic potential of breast cancer cell lines	2.98E-05	 	-0.692	 	-0.692	NME1,BHLHE41,PSAP,HIF1A,ROR1	5	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	malignant neoplasm of large intestine	malignant neoplasm of large intestine	3.03E-05	 	-1.067	 	-0.815	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,GLB1,DEFB132,GNA13,DCAF12,SYT17,SRPRA,ANXA2,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,PYGB,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,CCAR2,RUVBL1,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CD209,SLC25A13,RRP1B,ANKRD9,TRIM28,EGR1,ZFY,COPS3,STS,AOX1,CLUH,NCAM1,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PLCE1,DPP3,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,ADRA1A,BZW2,NCDN,TMEM8A,SLC41A3,ACO2,BAG3,NME2,TYMP,IMP4,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,PACS2,HOXA10,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,P2RY12,MAPRE3,MVD,GAB2,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,HSPA13,STXBP5,PHF1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,CENPV,C10orf71,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,RAN,GYG2,GHITM,MKI67,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,FARSA,NGRN,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,CDH11,ENAH,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,GSPT1,CAMK2D,SLC25A6,CDON,ALDH3A2,LYNX1,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,MDH2,BCKDK,DSP,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,RRAGD,ERBB4,HSPE1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,NEXN,PLEKHM2,MNAT1,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,TIMM8B,FLOT1,FGFR2,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,HSPA2,FOS,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,DOPEY2,MBD3,ABCC3,SIGLEC6,CSTF3,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,SLC24A2,RAB32,ADAM17,MSC,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,B4GALT2,FIS1,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,UTP4,TAF10,MMRN1,TUBB,VDAC2,NR2F1,RAB11FIP2,CTBP1,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,RAB10,CDK6,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,SOX17,TACR1,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,SLC27A3,MAT2A,USP9Y,RTN3	1012	
Cardiovascular System Development and Function, Cellular Movement	migration	migration of endothelial cells	3.10E-05	 	1.902	bias	-0.450	CTGF,CXCL12,HRAS,SDC4,HSPA5,CD63,SPRY4,ITGAV,STAB1,CDC42EP1,GSK3B,GPC1,TMSB10/TMSB4X,KLF2,SPP1,PTP4A3,DGKE,ANXA2,THRA,TARS,RTN4,IGFBP3,ALCAM,MAP2K3,CYR61,TFPI,CD151,APOE,LEP,MMP14,PKM,ADIPOQ,PROX1,HIF1A,TNFRSF12A,LIPA,HSP90AB1,FLNA,THBS1,MCAM,SAA1,TGFB2,PRKCE,CSNK2B,MAPKAPK2,AMOT,NFE2L2,SEMA3E,PLXNA1,VCAM1,PLXND1,CYP1B1,FGF1,GRN,ITGB2,WARS,EDIL3,NR4A1,PLAU,BMP6,MMP9	61	
Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of vesicles	3.11E-05	Increased	2.035	bias	0.496	LITAF,VPS28,PCLO,SESN2,ARF1,BAG3,HRAS,BIN1,VPS4A,SHC1,ARF6,ATG9A,FLNA,CHMP2A,ARFGAP1,ANXA5,KIT,PRKCE,STAM,PI4KB,SPP1,UCP2,HDAC2,CLTC,ANXA2,SYNPO2,CSF1,MAPT,PRKACA	29	
Neurological Disease	brain lesion	brain lesion	3.16E-05	 	0.583	 	0.881	ADAMTS8,APOB,HRAS,SH3GLB1,C1QA,MKI67,PANX1,CLIP1,MUC7,PRG4,EIF4G2,MCOLN3,MGAT4B,ALDOC,LCP1,SV2B,FAM126B,ANXA2,HSPA8,CCND2,VKORC1,CD300C,BTG2,MS4A7,SFRP1,ADCYAP1,TRAPPC5,NME1,GSTM5,CDH18,HLA-A,UBQLN1,BAG6,HMGN1,HYOU1,PPIA,H2AFZ,SMARCA4,TNXB,TOP2A,LURAP1L,MYO1D,STIM1,HPGDS,ALPK2,PLAT,CD209,PLXNA1,SLC25A13,SPTLC3,APP,SNTG2,COL5A3,KIF7,NTRK3,FLNC,BMF,P2RY12,AOX1,ABCC3,BMP6,ADRA1A,NCAM1,NAB2,VAMP5,SCN7A,BAG3,TMEM147,TYMP,BIN1,HS6ST1,LYNX1,RPL21,ITGAV,FAR2,CYBB,ANXA7,ADAMTS5,TRIOBP,HDAC2,TNPO1,CDK6,ATP6V1A,BCL2L1,PPP2R1A,ADAM12,ADRA2A,MAPT,CLCN7,UHRF1BP1L,TFPI,SIRPA,RNPEP,RAB1A,MSR1,PYCARD,PKM,HIF1A,MLH1,IRAK1,HLA-G,COL6A1,FLNA,DKK3,THBS1,ANXA1,ERBB4,F5,CTDNEP1,PRNP,AKR1C1/AKR1C2,RARS2,VANGL1,MAP3K1,SYNPO2,ANO2,SHB,MUC17,C6,CHI3L1,ADAM9,MMP9	122	
Cellular Movement	chemotaxis	chemotaxis of cells	3.23E-05	Increased	4.497	bias	0.591	SOCS3,CTGF,PFN1,CD4,CTSG,CXCL12,HRAS,GNB1,PTPRC,CD28,RHOG,ABCC1,CXCL14,CYBB,ITGAV,HOXA7,TXN,GNA13,C1QBP,AIF1,TMSB10/TMSB4X,CLCN3,LCP1,SPP1,CNR1,FLOT1,CAPG,ANXA2,NINJ1,TPSAB1/TPSB2,CDC42,YARS,RTN4,CAPN2,CYR61,ELMO2,C3AR1,SIRPA,RPL13A,CD151,APOE,ADAM17,LITAF,LEP,DAPK2,PPIB,MMP14,DUSP6,LGALS9,PPIA,PROX1,FAS,G6PC3,HLA-G,SHC1,CCDC88A,THBS1,ANXA1,EFNB1,SAA1,ERBB4,TGFB2,KIT,SERPINA1,STIM1,SEMA3B,MAPKAPK2,PRNP,SEMA3E,RPS19,CALR,VCAM1,EDNRB,TNFRSF1A,FCGR2A,GNA12,MAP3K1,HSPD1,CSF1R,PLXND1,APP,GRN,CXCL16,ITGB2,MT-ND1,LPAR1,NTRK3,CSF1,SERPINH1,FCER1G,PLAU,NCKAP1L,MMP9	93	
Cellular Function and Maintenance, Molecular Transport, Small Molecule Biochemistry	homeostasis	homeostasis of transition metal ion	3.26E-05	 	 	 	 	EIF2AK1,SLC31A1,ARF1,SCARA5,SLC39A6,SOD1,HIF1A,APP,HMOX1,FTL,APLP2,NEO1,TFRC,FECH,ATOX1,BMP6,SLC30A1,PRNP	18	
Infectious Diseases	infection	infection by RNA virus	3.33E-05	Increased	8.210	bias	 	TWF1,RAB5C,HRAS,RAD23A,PTPRC,POR,GATAD2A,LTF,CTSS,ETF1,CHCHD2,LSM3,MGAT1,CAPN6,AASS,ANXA2,PCK1,COPB1,NRBP1,TMEM127,BSG,STIP1,PSMA5,NDUFB7,BTG2,ATMIN,CTSB,TFRC,ATOX1,APOE,LAPTM5,ATP6V0B,ARPC1B,DAPK2,HLA-A,BAG6,LGALS9,FKBP1A,PFKL,ATRAID,TECR,ACTR3,FBXW11,TOP2A,SERPINA1,SNRPD3,RPL18,PLOD3,S100A1,PLOD2,CD209,SIGMAR1,ANKRD9,MECOM,DTX4,MED20,IMPDH2,FCGR2A,FGD6,DGAT2,SPATS2L,THAP11,PVR,PSMB6,LRRC8D,COPG1,APP,EIF3G,ITGB2,PDIA6,CSF1,BRINP2,GCSH,C6orf48,CYCS,GABARAP,SDF4,SLC31A1,ARF1,CD4,DPM1,RACK1,CXCL12,AP1B1,HSPA5,NPC1L1,CTBP1,CD28,HSPA4,TMEM132C,NDUFS6,CYBB,MID1IP1,STAB1,UQCRFS1,SNU13,ADAMTS5,KLF2,PTX3,STXBP1,CYB5B,GM2A,CLTC,MAPK8IP2,HSPA9,PSMC4,SLC4A7,RPL12,POLR2K,AES,NDUFA6,ATP6V0D1,RARRES3,UBE2E1,UTP11,ATP6V0C,ALG14,ZC3H7B,PPIB,CFTR,GANAB,HNRNPK,VPS4A,FAS,SSU72,MED15,LOC102724428/SIK1,RNH1,PSMA3,HMGCS1,NDUFAF3,SEC61G,DLGAP4,TRIM55,DVL1,R3HDM1,EXOSC5,FAU,STT3A,UTY,PANK3,MAT2A,UQCRC1,RTN3,MMP9	145	
Cellular Movement	cell movement	cell movement of connective tissue cells	3.40E-05	Increased	3.574	bias	1.616	APOE,CTGF,LEP,SLC4A2,MMP14,RACK1,ADIPOQ,HRAS,SDC4,ENAH,SGPL1,CCDC88A,LTF,THBS1,RHOD,KCNMA1,PRKCE,CYGB,GNA13,MAPKAPK2,WNT5B,SEMA3E,CALCRL,SPP1,ACTB,GNA12,MAP3K1,TMEM201,RAPGEF3,CSF1R,FGF1,FOS,CXCL16,CAPNS1,LPAR1,CDC42,CSF1,LIMA1,PRKACA,ARHGAP35,CAPN2,PLAU,CYR61,TNS1	44	
Organismal Injury and Abnormalities, Renal and Urological Disease	renal lesion	renal lesion	3.59E-05	 	-1.306	bias	-0.136	WHSC1,REM1,PCLO,VAC14,MNAT1,NPL,POR,GNB1,EIF4G2,GLB1,KEAP1,SPTB,DEFB132,GNA13,SLC2A5,LCP1,PPP1R1B,FGFR2,ANXA2,RCC2,NDUFB7,GPR65,BTG2,GCC1,EPHX1,APOE,NME1,PSMD7,OSGIN1,BAG6,CUBN,EEF1B2,ADIPOQ,PROX1,SMARCA4,ARFGAP1,PLIN2,ATP5J2,ALPK2,NFE2L2,S100A1,PLOD2,SRA1,MECOM,TUBB4B,TNFRSF1A,DGAT2,FOS,FLNC,DOPEY2,SOX9,C6orf62,C11orf68,BMP6,PCDH18,SESN2,SLC41A3,DIRAS1,GPC3,LHFPL2,MOCOS,STAB1,UQCRFS1,TUBA1C,BCAS2,RILPL1,LAMA2,GUF1,BCL2L1,RPL8,POLE3,CD151,SCD,PTGFR,SLC1A4,FAT3,PKHD1L1,ALAS1,FILIP1,HNRNPK,IRAK1,RPL14,SAA1,PPP1R2,LIAS,FAM171B,NPY1R,TUBG1,HPS1,PYGB,CXCL16,POLR3B,PSMD2,MUC17,SLC25A5,SLC29A4,LDB3,MKI67,APRT,LGMN,ZNF605,KIF21A,POU6F2,HADHB,CALCRL,NANOS1,CENPB,DPY19L1,TUBB2A,SH3GL1,CCND2,BSG,IL10RA,CCT3,ARHGAP35,MAP2K3,SFRP1,AIDA,SETBP1,FH,CYR61,TCF7,GSTP1,PHLPP1,SLC4A4,S100A11,ADAM17,KLHL18,RALA,BTG3,HLA-A,DUSP6,FKBP1A,XPOT,ATP6AP1,CADM2,PHB,MT-CYB,ANXA5,TBC1D12,TRIM16,TOP2A,PRKCE,RPS12,PLAT,CD53,PLXNA1,ATXN2L,COL5A3,MRPL51,GLIS2,PPP1R16B,DOCK8,SREBF2,GABARAP,XPO5,TUBB,METAP2,GSPT1,SIAH2,RET,MFSD3,SLC6A8,ACSL3,SPP1,TRIOBP,POLR1A,SGCG,ANLN,GCNT2,PPP2R1A,IL1RN,TMOD1,RNPEP,RAB1A,MMP14,PKM,HIF1A,HMOX1,SLFN5,PCK2,FLNA,KCNMA1,THBS1,CSPG4,ERBB4,KIT,ASAP3,ADCY2,FRMD1,TMEM126B,TPST2,MAP3K1,NXPH4,ZBTB7C,GUK1,NFKBIZ,CSF1R,MT-ND5,MMP9,SLC47A1	201	
Infectious Diseases	viral entry	viral entry by virus	3.62E-05	Increased	2.853	bias	1.643	ATP6V0C,CD209,ATP6V0B,CD4,CXCL12,FGFR2,ATP6V1A,ATP6AP1,COPG1,DUSP3,ITGAV,TFRC,MAP2K3,GSK3B,CSNK2B,ATP6V1B2	16	
Cellular Movement, Hematological Disease, Immunological Disease, Inflammatory Disease, Inflammatory Response, Respiratory Disease	allergic pulmonary eosinophilia	allergic pulmonary eosinophilia	3.66E-05	 	 	 	 	ENO1,PRDX1,CTSS,ACTB,TKT,ACO2,ADIPOQ,HNRNPAB,GAPDH,ALDOA,HSPA5,TUBB	12	
Molecular Transport, Protein Trafficking	export	export of protein	3.66E-05	 	 	 	 	CALR,AHCYL1,CSE1L,HSPA9,RAN,XPO5,NME2,EIF5A,UHMK1,GSK3B,NUTF2,XPO6	12	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	gastrointestinal tract cancer	gastrointestinal tract cancer	3.67E-05	 	-1.107	 	-0.593	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,POR,GLB1,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,SLC1A5,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,VAT1,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,RUVBL1,CCAR2,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CD209,SLC25A13,RRP1B,ANKRD9,EGR1,TRIM28,ZFY,COPS3,STS,CALM1 (includes others),AOX1,NCAM1,CLUH,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,CHST11,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,GEM,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,HINT1,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,RAB38,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,APOE,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,SIGMAR1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ADRA1A,BZW2,NCDN,MEGF9,TMEM8A,SLC41A3,ACO2,BAG3,NME2,TYMP,IMP4,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,CXCL14,PACS2,HOXA10,HOXA7,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,CHI3L1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,ACSF2,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,P2RY12,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,IL1RN,HSPA13,STXBP5,PHF1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,RBM18,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,NPM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,TUBB4B,SLC25A1,SPATS2L,PVR,CSTB,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,PCDH18,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,C2orf83,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,RPL18A,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,HOXA6,RAN,GYG2,GHITM,MKI67,GSS,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,NGRN,FARSA,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,SDCCAG3,CDH11,ENAH,LYZ,PHB,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,CD63,GSPT1,CAMK2D,SLC25A6,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,MDH2,BCKDK,DSP,PCNXL2,C7orf50,HK1,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,CD83,RRAGD,ERBB4,HSPE1,OAZ1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,NEXN,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,FGFR2,TIMM8B,FLOT1,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,DOPEY2,MBD3,ABCC3,CSTF3,SIGLEC6,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,DUSP1,SLC25A39,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,RNH1,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,BSG,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,SLC24A2,RAB32,ADAM17,MSC,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,COX4I1,MYH1,DNAH12,LETM1,ADRM1,DTX4,TYROBP,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,B4GALT2,FIS1,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,XPO5,CXCL12,UTP4,MMRN1,SDC4,TAF10,TUBB,VDAC2,NR2F1,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RPL13A,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,TACR1,SOX17,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,DIP2C,LPAR1,ZNF117,MAT2A,SLC27A3,USP9Y,RTN3	1066	
Cardiovascular Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	myocardial infarction	myocardial infarction	3.73E-05	 	-0.393	 	0.242	APOE,DUSP6,GDF15,ADIPOQ,CXCL12,HIF1A,NPC1L1,NNMT,HMOX1,CYBB,ITGAV,PRKCE,TUBA1C,GCLM,GSK3B,MAPKAPK2,PLAT,PTX3,PPIF,TNFRSF1A,TUBB4B,FCGR2A,TUBG1,TUBB2A,F13A1,THRA,SOD1,CSF1R,APP,ITGB2,ADRA2A,VKORC1,IL1RN,CSF1,SH2B3,FCER1G,CCT7,P2RY12,CD14,LRP8,C6,TFPI,MMP9,ADRA1A	44	
Cell-To-Cell Signaling and Interaction	cell-cell adhesion	cell-cell adhesion	3.83E-05	 	0.166	 	0.222	CSTA,NME1,CADM3,LEP,PTPN23,LRP6,RACK1,CXCL12,ADGRL1,CDH11,PTPRC,OGT,SHC1,SRPX2,TNXB,CDON,MCAM,NLGN4Y,DAB2,C1QBP,RET,DSP,PI4KB,FERMT3,CD209,VCAM1,TP63,DVL1,PVR,CXCL16,ITGB2,ERP29,CDC42,LIMS1,WBP2,ALCAM,CLDN2,SOX9,CYR61,NCAM1,RPSA,CD151	42	
Cancer, Cardiovascular Disease, Organismal Injury and Abnormalities	hemangioma	hemangioma	3.90E-05	 	 	 	 	CXCL12,HRAS,MKI67,NPAS2,ADGRL1,CEBPG,PAX5,PLCE1,CCND3,KEAP1,CXCL14,STAB1,ANXA7,RET,COL27A1,FGFR2,SDHC,BCL2L1,PPP2R1A,INPP4B,CCND2,ADCYAP1R1,CDH20,SH2B3,IGFBP3,ALCAM,FH,SETBP1,GSTP1,ALK,CARS,GSTM5,DDIT3,HLA-A,MMP14,CUBN,HMGN1,LRP6,CTNNA1,HIF1A,DCLK1,SMARCA4,MLH1,FANCE,CADM2,HSP90AB1,THBS1,KIT,MYH1,RPN1,VCAM1,EDNRB,MECOM,NQO1,RNF43,MAP3K1,NFKBIZ,CSF1R,CYP1B1,SERPINE2,AFF3,ITPA,LPAR1,NTRK3,EPHB3	65	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal cancer	intestinal cancer	3.95E-05	 	-1.000	 	-0.420	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,GLB1,DEFB132,GNA13,DCAF12,SYT17,SRPRA,ANXA2,RCC2,NDUFB7,PSMA4,ALCAM,ELMO2,RCN3,KDM1B,GBP1,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,ATP6V1F,NR4A1,RPL37,BTBD2,PIGU,AKR1C3,EML4,DNAJC15,CBX5,ABCB11,SNRPD1,TUBA1C,NSMAF,ARRDC2,UBL4A,GUF1,BCL2L1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,COL6A1,F8,C16orf59,LASP1,NDUFB4,AKR1C1/AKR1C2,PYGB,TXNDC12,FECH,MAP4K4,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,LRFN5,SLC22A15,PRG4,FAM124B,PXK,PNKD,GPR26,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,ISLR,SNRNP25,RMND1,ARHGAP35,SORL1,HLA-A,LRP6,ST6GALNAC4,FKBP1A,CCAR2,RUVBL1,SDC3,RNF185,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,FKBP5,SMPD3,LIMCH1,RPS24,CD209,SLC25A13,RRP1B,ANKRD9,TRIM28,EGR1,ZFY,COPS3,STS,AOX1,CLUH,NCAM1,RGMA,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PLCE1,DPP3,AAGAB,COL27A1,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,SLC4A7,MAGED2,ATP10A,SLC39A3,TARS,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,HIGD1A,PCDHAC2,PCDH19,FLYWCH2,CLCN4,THBS1,DUSP10,CYGB,ASAP3,SZRD1,CEBPB,SYNPO2,EMP1,PLCB4,PAG1,RPS27L,PPP2R1B,HLTF,SLC47A1,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,GATAD2A,SRPX2,LTF,HIGD2A,COMMD2,PLEKHO2,SPTB,STAM,GNG12,MRPL24,ALDH1B1,MFAP5,CNR1,SMOC2,PXDC1,DES,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,ESR2,FKBP2,FBXO10,SLC4A2,PLXNA3,CDH18,CUBN,HS2ST1,GDF15,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,SIGMAR1,RPL4,MLF2,FUCA2,GNA12,GLRX2,SLC6A6,STON1,SLC39A6,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,ADRA1A,BZW2,NCDN,TMEM8A,SLC41A3,ACO2,BAG3,NME2,TYMP,IMP4,SLC35F6,MRVI1,C3orf17,MRM2,CD28,TMEM132C,SAE1,MOCOS,PACS2,HOXA10,STAB1,DPM3,PFKFB3,FSTL3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,CMSS1,TRIM35,ARSA,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,ST3GAL6,MGAT5,HSPD1,PSME3,ATIC,FAM49A,DEGS1,NFE2L1,SERPINE2,KCTD13,CLGN,SLC33A1,MAF,PCDH7,VWA5A,C1QB,MUC7,BCAT1,ABR,ABCC1,RIMS3,PDRG1,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,IL10RA,ALDOA,LRP8,AIDA,SLC35A4,PHLPP1,SLC4A4,ATP5G1,TMEM129,CTNNA1,SP2,MACC1,SRGAP1,TBC1D12,PRKCE,SARS,YIPF2,PLOD3,PLAT,RPS19,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,COL5A3,CLDN5,DOCK8,UQCR10,P2RY12,MAPRE3,MVD,GAB2,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,MACROD1,ERH,PSMC4,MARS,UBE2D2,PLEKHH2,HSPA13,STXBP5,PHF1,SPX,B3GALT6,LEP,PRDX5,PDGFA,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,SENP3,GSTM4,HSD11B2,BHMT2,SEMA3E,FRMD1,ADCY2,DLGAP4,CENPV,C10orf71,RARS2,F13A1,CSF1R,ARHGEF10L,ENO1,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,ATP6V1B2,MMP9,SHMT2,CARM1,ADAMTS8,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CSE1L,DGKG,KNSTRN,AIF1,AHCY,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,EIF3K,EPHX1,HTATIP2,PSMD7,ARPC1B,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,FCGR2A,SLC25A1,SPATS2L,PVR,RNF6,MYO5A,CSF1,SEPHS1,SOX9,SDF4,SEPT9,DPM1,RABEP1,SLC9A9,SCN7A,AP1B1,GPC3,CTSD,OSCP1,CCT5,FNDC4,ERAL1,ADAMTS5,NAGA,STXBP1,HDAC2,STK39,UROS,CBX6,CREG1,FIG4,EIF4E2,FYB,SMPD2,TXNRD1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,DDX21,IGFBP4,F2RL3,PLGRKT,PCDHGB4,ZNF219,ALAS1,FILIP1,PHLDB2,FARSB,HLA-G,GTPBP2,MT-CO1,PATL1,TP63,TRIM55,TRIM2,WIPF3,POLR3B,THEMIS2,CPAMD8,RAN,GYG2,GHITM,MKI67,EXPH5,BBS1,RAD23A,AHSA1,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,FARSA,NGRN,INPP4B,FNDC1,RTN4,B3GNT5,SETBP1,GSTP1,BTG3,TTLL4,TMEM11,HYOU1,CDH11,ENAH,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,PAICS,CASK,SNTG2,CLIC6,HIST1H1E,GLIS2,RHBDD2,BRINP2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,KCND3,CD4,MYH15,UNC5B,MAP1B,TCEB2,GSPT1,CAMK2D,SLC25A6,CDON,ALDH3A2,LYNX1,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,MDH2,BCKDK,DSP,C7orf50,PCNXL2,FERMT3,SLC4A5,THUMPD3,TRIOBP,GSDMB,XYLT1,TALDO1,HSPA9,DGKE,GPAA1,UBXN11,CD3G,SH2B3,MAPT,RARRES3,NUAK1,CLCN7,DNPEP,ARL2,SPIRE1,CNRIP1,SH3RF3,KIAA1191,ATF5,ILF2,MRPS30,RRAGD,ERBB4,HSPE1,KCTD1,OGDH,SHANK2,MAPKAPK2,ADAMTS15,CALR,COL5A2,BHLHE41,HSPH1,RNF43,MAP3K1,OAF,VSIG4,PLXND1,KIAA1683,P4HA1,PLBD2,TMEM2,CYC1,APOC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,NEXN,PLEKHM2,MNAT1,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KIF1A,KEAP1,CEP170B,ST6GALNAC2,ATF4,UNG,LCP1,PPP1R1B,PPTC7,TIMM8B,FLOT1,FGFR2,NPY5R,NDN,HSPA8,CTSA,FBXW5,TOMM22,FSCN1,GPR65,ATMIN,SLC35B4,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,OSBPL11,TTC23,CSNK2B,STT3B,TMC2,ZNF362,TRIB3,HSPA2,FOS,MT-ND1,ALDH1L2,FAM129A,FLNC,PPT1,DOPEY2,MBD3,ABCC3,SIGLEC6,CSTF3,PPIP5K2,SESN2,MBP,RACK1,OGFOD1,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,CHMP1A,LACTB,C20orf27,LAMA2,SRPRB,KCNK2,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,DMXL2,SLC3A2,KCNG1,ALG3,CDH20,NDUFA6,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,DOK5,ATP6V0C,UBXN1,MSR1,TMEM60,HNRNPK,MLH1,SHC1,TWF2,PREPL,PPP1R2,KIAA0232,TRABD2A,FAM166A,UBIAD1,LIAS,LONP1,PSAT1,CAPZB,ZNF358,TUBG1,PWWP2B,NDUFV3,NQO1,HPS1,TRPA1,LARP6,NRBF2,FGF1,SHB,CIDEA,SCARA3,KIF5B,NOP16,TTL,MUC17,IVD,FHL5,CADM3,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,CALCRL,CFL1,THSD4,SLC24A3,TKT,TUBB2A,AASS,CCND2,NR1D1,CD68,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,ALK,S100A11,SLC24A2,RAB32,ADAM17,MSC,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,TTC1,DCLK1,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,ACAP2,PSMD14,STIM1,TPO,ZNF70,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,FGD6,CYP1B1,APP,EIF3G,WARS2,B4GALT2,FIS1,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,CXCL12,XPO5,UTP4,TAF10,MMRN1,TUBB,VDAC2,NR2F1,RAB11FIP2,CTBP1,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,SNRPF,GCNT2,RAB10,CDK6,ST6GALNAC3,PKN1,EPRS,TIE1,SEL1L,EFS,PPP2R1A,VDAC1,JTB,RNF165,EPB41L3,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,FAS,EVC,SOX17,TACR1,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,PRNP,TRAF7,CYP27A1,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,MT-ND5,DIP2C,LPAR1,ZNF117,SLC27A3,MAT2A,USP9Y,RTN3	1013	
Cell Death and Survival	cell death	cell death of breast cancer cell lines	3.95E-05	 	0.071	 	-0.126	CTGF,RACK1,BAG3,DNAJC15,HSPA5,SLC9A1,ODC1,SLC25A6,CSE1L,GSK3B,KLF8,BCAS2,LMO4,FGFR2,RPAP3,SDHC,BCL2L1,CCND2,CDC42,DUSP1,IGFBP3,TFRC,DUSP4,MAP2K3,SFRP1,CYR61,ESR2,FTH1,PEBP1,SULF1,NME1,SFRP2,OSGIN1,MMP14,PKM,ADIPOQ,HSPB8,UGCG,HIF1A,MLH1,FAS,HMOX1,RABL6,HINT1,PCK2,PHB,THBS1,TGFB2,DAB2,PRKCE,HCST,PRNP,TP63,TNFRSF1A,NQO1,HSPD1,CEBPB,NDUFA13,KIFC3,PEA15,CYCS,ARHGDIA	62	
Molecular Transport	quantity	quantity of metal ion	3.99E-05	Increased	3.128	bias	0.482	RAP2B,PLCB2,CXCL12,HRAS,MRVI1,HSPA5,PANX1,SLC9A1,GNB1,PTPRC,CD28,CAMK2D,PLCE1,CPM,LYNX1,MCOLN3,CYBB,GNA13,C1QBP,SPP1,LAIR1,STK39,PPP1R1B,RAPGEF3,FIG4,ANXA2,TPSAB1/TPSB2,BCL2L1,ADCYAP1R1,ADRA2A,MAPT,PRKACA,VDAC1,ADCYAP1,AKR1B1,C3AR1,TMOD1,SLC4A4,PTGFR,APOE,LEP,F2RL3,PPIB,HYOU1,PPIA,FKBP1A,EIF2S1,FAS,TACR1,SHC1,LYZ,MCAM,SAA1,HSD11B2,STIM1,HSPB6,PRNP,S100A1,CALR,SIGMAR1,VCAM1,EDNRB,FCGR2A,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,MARCKSL1,CSF1,FCER1G,NUCB2,CLDN2,PLAU,ADRA1A,NCAM1	78	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities	familial motor neuron disease	familial motor neuron disease	4.00E-05	 	 	 	 	SIGMAR1,CHCHD10,C9orf72,RRM2B,GARS,HSPB8,SOD1,C1QB,GRN,UCHL1,BCL2L1,MT-ND5,PARK7,MAPT,ERBB4,CHCHD2,SQSTM1,ATP13A2	18	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of lipid	4.20E-05	 	0.152	 	-0.076	PLIN1,APOB,CXCL12,TAF10,ODC1,GLB1,ABCC1,PLIN5,MID1IP1,ABCB11,GSK3B,LPIN2,KLF2,GULP1,ACP2,CNR1,GM2A,NR1H3,PCK1,ARSA,SMPD2,BCL2L1,IL1RN,PLTP,IRF8,ADCYAP1,FH,C3AR1,PAFAH1B2,APOE,SCD,LEP,MSR1,ADIPOQ,UGCG,HEXA,H2AFZ,FAS,GRINA,HMOX1,GBA,SAA1,PLIN2,NFE2L2,UCP2,FCGR2A,CEBPB,APP,LAMP2,LPAR1,SREBF2,SREBF1,SLC36A1,APOC1,PSAP,PLAU	56	
Infectious Diseases	infection	infection of tumor cell lines	4.21E-05	Increased	6.884	bias	 	SDF4,TWF1,RAB5C,SLC31A1,ARF1,DPM1,CD4,RACK1,AP1B1,RAD23A,CTBP1,TMEM132C,NDUFS6,ETF1,MID1IP1,CHCHD2,LSM3,SNU13,MGAT1,ADAMTS5,KLF2,CAPN6,CYB5B,GM2A,CLTC,MAPK8IP2,HSPA9,AASS,SLC4A7,POLR2K,PCK1,COPB1,NRBP1,CDC42,STIP1,NDUFA6,ATP6V0D1,NDUFB7,TFRC,ATOX1,UBE2E1,UTP11,APOE,ALG14,LAPTM5,ATP6V0B,ARPC1B,DAPK2,PPIB,BAG6,TECR,ATRAID,HNRNPK,VPS4A,FAS,SSU72,FBXW11,LOC102724428/SIK1,PLOD3,PRNP,S100A1,CD209,SEC61G,ANKRD9,MECOM,DTX4,TRIM55,MED20,FGD6,EXOSC5,DVL1,SPATS2L,THAP11,LRRC8D,FAU,COPG1,STT3A,UTY,EIF3G,PDIA6,NTRK3,BRINP2,GCSH,PANK3,CYCS,MAT2A,GABARAP,UQCRC1,MMP9	89	
Post-Translational Modification, Protein Degradation, Protein Synthesis	proteolysis	proteolysis	4.22E-05	Increased	2.236	bias	0.476	SPCS1,CSTA,TRAF3,CMA1,CTSG,NCSTN,SDC4,PTPRC,CTSD,CNDP2,LGMN,DPP3,CTSS,CHMP1A,CLN6,PSMB5,HDAC2,PSMC4,NR1H3,CPA3,AURKAIP1,HSPA8,BCL2L1,CTSA,ADAM12,CTSB,CAPN2,SFRP1,RNPEP,APOE,USP18,ADAM17,BAG6,MMP14,FAS,OGT,F8,FBXW11,F5,TRABD2A,SERPINA1,LONP1,PLAT,ADRM1,DNAJC1,CSTB,SERPINE2,CAPNS1,TPP1,PLAU,ADAM9,MMP9	52	
Nervous System Development and Function	myelination	myelination	4.30E-05	 	-0.518	 	-1.594	NAB2,APOE,PLP1,PDGFA,MBP,MAP1B,UGCG,HEXA,TYMP,SMARCA4,CERS2,PTPRC,ERBB4,MTMR2,GSK3B,GPC1,BCKDK,NFE2L2,IL11RA,TYROBP,LAMA2,GABBR1,NR1H3,FIG4,THRA,ARSA,ZPR1,MYO5A,MYOC,CLDN5,NTRK3,CSF1,TENM4,RTN4,PSAP,C6,MMP9,NCAM1,RPSA	39	
Gene Expression	transactivation	transactivation	4.34E-05	 	1.214	bias	-1.730	NPM1,NR6A1,CTGF,MAF,HRAS,MNAT1,DUSP3,PEG10,LTF,CCND3,GNA13,TXN,ZBTB16,NKIRAS2,NR1H3,JUNB,HMGA1,NDN,PLAG1,CCND2,PRKACA,GAPDH,ATOX1,MAP2K3,TCF7,ESR2,APOE,NME1,HTATIP2,MSC,DDIT3,PRDX1,SMARCA4,TRIM16,DAB2,NFE2L2,S100A1,SRA1,UCP2,DTX4,MECOM,EGR1,APP,MARCKSL1,FOS,GLIS2,NTRK3,SREBF1,FKBP4,NR4A1,NR5A2,SIM1,NAB2,SOCS3,NR2F1,CD28,PLCE1,NEO1,SIAH2,GSK3B,RET,KLF2,ADAMTS5,SPP1,HDAC2,LMO4,HSPA9,PFDN5,THRA,POLR2K,KLF4,PKN1,FOSB,ADAM12,CDC42,RBX1,XRCC6,IRF8,SIRPA,UBE2I,IGFBP4,PTGFR,PYCARD,PKM,HIF1A,RPL7A,HNRNPK,IRAK1,STUB1,ERBB4,MAPKAPK2,DVL1,CEBPB,EDF1,NFE2L1,UTY,FGF1,MMP9,CARM1	99	
Cell Death and Survival	cell death	cell death of cervical cancer cell lines	4.47E-05	 	-1.441	 	-1.129	APOB,PRPF19,HRAS,OGFOD1,MIF4GD,CHTOP,G0S2,EIF4G2,CCND3,MCOLN3,TXN,GSK3B,RAD51C,BIRC7,SPP1,FST,CENPB,TXNRD1,BCL2L1,PPP2R1A,CCND2,CTSB,SQSTM1,VDAC1,FTH1,NME1,RAB32,TOLLIP,DDIT3,UBQLN1,BAG6,PKM,PPIA,CCAR2,PRAF2,FAS,HNRNPK,GRINA,UCHL1,CCT4,ACSM5,NAA38,TOP2A,TCP1,SMPD3,RPS24,CALR,SEC61G,TAF6,UCP2,ADRM1,LETM1,DCTN3,TNFRSF1A,MAP3K1,NABP1,SOD1,NFKBIZ,CSF1R,APP,FOS,IMMT,LIMS1,NR4A1,COX5A	65	
Cell-To-Cell Signaling and Interaction, Nervous System Development and Function	long-term potentiation	long-term potentiation	4.57E-05	 	-0.081	bias	-1.728	APOE,SLC24A2,ITGA8,HRAS,HNRNPK,CDH11,CCDC88A,GBA,EFNB1,ERBB4,CYBB,GSK3B,SHANK2,CACNG8,CLCN3,PLAT,PRNP,SRR,HDAC2,LMO4,PPP1R1B,CNR1,EGR1,GABBR1,DGKE,RAPGEF3,SOD1,APP,SERPINE2,CAPNS1,ADCYAP1R1,NTRK3,IL1RN,MAPT,STIP1,ADCY1,PRKACA,RTN4,TSPO,PSAP,LRP8,STXBP5,VDAC1,CPEB1,ESR2,MMP9,NCAM1	47	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of cells	4.58E-05	Increased	4.088	bias	1.316	NPM1,GAB2,PFN1,CD4,RACK1,C1QA,BIN1,CLIP1,PTPRC,RHOG,ABR,ITGAV,CLCN3,KLF2,GULP1,EIF2AK1,PTX3,CLTC,RAPGEF3,CAPG,HSPA8,CDC42,CD14,IRF8,SIRPA,LEP,RALA,MSR1,PYCARD,ADIPOQ,FAS,HMOX1,ARF6,THBS1,SAA1,ANXA5,ANXA1,PRKCE,TUB,STIM1,MAPKAPK2,CALR,UCP2,FCGR2A,CEBPB,APP,ITGB2,CSF1,TREM2,ASAP2,FCER1G,PLAU	52	
Cell Death and Survival, Neurological Disease	cell death	cell death of hippocampal neurons	4.70E-05	 	0.487	 	0.775	APOE,LEP,DDIT3,VAPA,HYOU1,JUNB,FAS,APP,CTSD,NTRK3,STIP1,MAPK10,CYCS,GSK3B,ADCYAP1,RPS3,ATP13A2,UNG,PLAT,PRNP	20	
DNA Replication, Recombination, and Repair	metabolism	metabolism of DNA	4.75E-05	 	0.770	 	-0.187	NPM1,SOCS3,PFN1,VPS28,RRM2B,RAN,CTSG,CXCL12,HRAS,TYMP,BIN1,CD28,KEAP1,GSK3B,AAGAB,BIRC7,DNASE2,CNR1,THRA,HMGA1,CDK2AP1,TPSAB1/TPSB2,BCL2L1,ADRA2A,BSG,DUSP1,MAPT,XRCC6,RTN4,CAPN2,ADCYAP1,POLD2,POLE3,S100A11,IGFBP4,APOE,NME1,LEP,DDIT3,MSR1,PDGFA,PPIB,UBQLN1,PAM16,HMGN1,ADIPOQ,PPIA,REXO2,FAS,SHC1,CCDC88A,TOP2A,TGFB2,SERPINA1,NACC1,MAPKAPK2,UBA5,PRNP,CD53,CALR,TIAL1,SOD1,XIST,APP,GRN,ENO1,KCTD13,CSF1,PPT1,PEA15,NR4A1	71	
Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism	quantity	quantity of Ca2+	4.77E-05	Increased	2.529	bias	-0.280	RAP2B,PLCB2,CXCL12,HRAS,MRVI1,HSPA5,PANX1,SLC9A1,GNB1,PTPRC,CD28,CAMK2D,PLCE1,LYNX1,MCOLN3,CPM,GNA13,C1QBP,SPP1,LAIR1,PPP1R1B,RAPGEF3,FIG4,ANXA2,TPSAB1/TPSB2,BCL2L1,ADCYAP1R1,ADRA2A,MAPT,PRKACA,VDAC1,ADCYAP1,C3AR1,TMOD1,PTGFR,APOE,LEP,F2RL3,PPIB,HYOU1,PPIA,FKBP1A,EIF2S1,FAS,TACR1,SHC1,LYZ,MCAM,SAA1,STIM1,HSPB6,PRNP,S100A1,CALR,SIGMAR1,VCAM1,EDNRB,FCGR2A,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,MARCKSL1,CSF1,FCER1G,NUCB2,PLAU,ADRA1A,NCAM1	72	
Cell Morphology	size	size of cells	4.79E-05	 	 	 	 	NPM1,GAB2,SOCS3,PLIN1,HRAS,PTPRC,IP6K3,CCND3,CXCL14,SPTB,RET,CLCN3,KLF2,LAMTOR4,CFL1,SGCG,LAMA2,CLTC,SURF1,TPM3,NR1H3,SLC12A7,RAPGEF3,THRA,PCK1,ARSA,MLST8,BCL2L1,CDC42,DUSP1,TXN2,MAPT,RTN4,ADCYAP1,PHLPP1,PTGFR,APOE,ADAM17,LEP,PYCARD,PRDX1,MMP14,GDF15,ADIPOQ,SMARCA4,FAS,SYNM,LIPA,CES1,SORBS1,KCNMA1,ANXA1,EFNB1,PLIN2,S100A1,TRIM55,AP3D1,MAP3K1,ST3GAL6,SOD1,SNCG,CEBPB,PSME3,SLC5A3,POMGNT1,FGF1,APP,MYO5A,MARCKSL1,SREBF2,FLNC,LIMS1,CSF1,SREBF1,APOC1,NR4A1,ADRA1A,NCAM1	78	
Cancer, Organismal Injury and Abnormalities	growth	growth of malignant tumor	4.80E-05	 	1.766	 	0.253	EEF1A1,ICMT,NPM1,SOCS3,CTGF,RACK1,CXCL12,HRAS,DIRAS1,MKI67,GPC3,ODC1,SAE1,PEG10,PLCE1,CCND3,CTSS,GSK3B,RET,AHCY,PFKFB3,SPP1,LAIR1,HDAC2,PTP4A3,PYGO2,BCL2L1,ADCYAP1R1,BSG,DUSP1,IL1RN,BTG2,IGFBP3,CTSB,SFRP1,SQSTM1,CYR61,AKR1B1,ESR2,ALK,CD151,LITAF,FHL1,RALA,SFRP2,LEP,DDIT3,BTG3,GDF15,PKM,ADIPOQ,PROX1,RUVBL1,HIF1A,TAX1BP3,NELFE,THBS1,MCAM,FBXW11,TGFB2,KIT,RHOBTB2,PRKCE,ACVR1C,PLAT,COX17,TP63,EGR1,LZTS2,FGF1,GRN,FOS,CSF1,NR4A1,BMP6,ADAM9,MMP9	77	
Cell Death and Survival	apoptosis	apoptosis of pheochromocytoma cell lines	4.89E-05	Increased	2.069	 	1.634	NPM1,GEM,TNFRSF1A,MAP3K1,SOD1,FAS,APP,SHC1,PPP2R1A,DYNLL1,CDC42,MAPT,ERBB4,BTG2,MAPK10,PSAP,CYCS,MAP2K3,GSK3B,RPS3,SIRPA	21	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	lymphohematopoietic neoplasia	lymphohematopoietic neoplasia	4.90E-05	 	-1.400	 	-0.791	NPM1,SCFD2,KLHDC8B,WHSC1,PCLO,RRM2B,TIGIT,CTSG,NEXN,ODC1,CLIP1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,CSE1L,STAM,LSM3,GNA13,TMSB10/TMSB4X,MGAT1,UNG,ICT1,LAIR1,PPTC7,MSMO1,FGFR2,ANXA2,DCTD,CD52,DES,MYL9,CYP4B1,BTG2,DUSP4,ACTG1,ESR2,RPL41,SCN11A,STEAP3,EPHX1,APOE,NME1,PRDX1,CUBN,DPM2,SEC23B,GDF15,EEF1B2,ADIPOQ,PPIA,CRAT,SMARCA4,COL16A1,HSP90AB1,SERPINA1,SNRPD3,AMOT,FKBP3,SIGMAR1,PLOD2,RPL4,MECOM,MT-TY,TUBB4B,FCGR2A,RNF157,STON1,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,FAM129A,CCT7,RPL37,BMPER,ABCC3,BMP6,CSTF3,ID4,NUTF2,ADRA1A,EEF1A1,SLC25A43,TRAF3,SESN2,ARL6IP5,RABEP1,ZNF79,RACK1,ACO2,BAG3,MRPL47,HSPA5,C3orf17,NNMT,CD28,TMEM132C,SAE1,RPS13,HOXA7,ABCB11,STAB1,TUBA1C,MTMR2,ADAMTS5,NSMAF,PFKFB3,PSMB5,HDAC2,RERG,UROS,TMC5,SLC12A7,FYB,TXNRD1,BCL2L1,SDCBP,TLN2,ADAM12,SLC25A39,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,TFPI,CCPG1,TNS1,PPAT,UBE2I,RPSA,POLE3,IGFBP4,RAB4A,RPLP1,SRPX,MSR1,MECR,FAT3,ALAS1,MLH1,IRAK1,HLA-G,SHC1,COL6A1,F8,MCAM,PPP1R2,KLHL42,DNAAF1,LONP1,ATP13A2,MT-CO1,SLC20A1,MT-ATP6,TP63,TUBG1,NQO1,ST3GAL6,TRPA1,HSPD1,PSME3,ATIC,CXCL16,SCARA3,SLC33A1,PSMD2,MUC17,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,RAN,NCSTN,MKI67,RPS11,BBS1,RAD23A,CECR1,BCAT1,ZBTB7B,SGPL1,C9orf91,LRFN5,LGMN,PRG4,MPV17L2,PLCXD1,CTSS,GAA,ABCC1,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,CFL1,SLC24A3,TUBB2A,HMGA1,JUNB,ROR1,KIAA0100,CTPS1,SH3GL1,ACAD11,NUGGC,CCND2,CD68,DHRS9,C19orf53,CNTNAP4,STIP1,ARHGAP35,CCT3,MAP2K3,LRP8,TCF7,CYR61,SETBP1,GSTP1,ALK,SORL1,MSC,SLC24A2,ADAM17,RALA,NID2,PSMB10,HLA-A,LRP6,ST6GALNAC4,FKBP1A,KAZN,MACC1,LIPA,RPL35,LYZ,MYO5C,TTC7B,MT-CYB,SCN3A,ANXA5,TOP2A,STIM1,NPTXR,RPS12,LIMCH1,LAMB4,RPS24,MYH1,CCDC68,RPS19,SLC25A13,PTPRK,SYNGR2,IMPDH2,ACTB,EGR1,TRIM28,STXBP6,CYP1B1,STS,ITGB2,B4GALT2,PSME1,MRPL51,CLDN5,PDIA6,IMMT,UQCR10,USP22,BMF,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,CXCL12,TCEB2,VDAC2,CTBP1,PAX5,NARS,SLC29A3,SLC25A6,RPL13,DPP3,CDON,COMT,ANXA7,GSK3B,RET,COL27A1,DSP,EIF2AK1,SPP1,POLR1A,ANLN,PSMF1,CDK6,ST6GALNAC3,HIST1H2BK,ATP10A,MARS,RPL28,UBXN11,CD3G,IL1RN,SH2B3,CD14,GNL3,LFNG,STXBP5,CYP4A11,RPL13A,RNPEP,RBBP8,EPSTI1,HIF1A,FAS,ERV3-1,MPEG1,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,F5,KIT,SEMA3B,HCST,ASAP3,SHANK2,ALPL,PI4KB,ADAMTS15,CALR,COL5A2,TPST2,RARS2,MAP3K1,R3HDM1,CLEC9A,GABBR1,CEBPB,CSF1R,KIAA1683,ARHGEF10L,MT-ND5,PAG1,SLC16A1,EPHB3,UQCRC1,ADAM9,SEMA4B,SHMT2,ATP6V1B2,MMP9	372	
Cell Death and Survival	cell death	cell death of sarcoma cell lines	4.92E-05	 	-0.456	 	-0.729	S100A11,CSTA,PRDX1,OSGIN1,PYCARD,BAG6,RACK1,TMBIM6,HIF1A,HSPA5,PRAF2,FAS,VDAC2,OGT,DKK3,TOP2A,NUPR1,ATF4,OAZ1,HCST,MAPKAPK2,TP63,SPP1,DCTN3,GPS2,TNFRSF1A,TRIM28,MAP3K1,CDK6,HMGA1,NFKBIZ,NDN,BCL2L1,LAMP2,CAPNS1,LIMS1,TXN2,CTSB,ATMIN,NUAK1,SFRP1,IRF8,PLAU,FTH1	44	
Immunological Disease	allergy	allergy	5.10E-05	 	0.451	 	-0.225	EEF1A1,GAB2,PLIN1,ACO2,STARD7,MKI67,HSPA5,TUBB,CD63,VDAC2,NR2F1,PTPRC,CD28,LGMN,PTGES2,CTSS,IFI30,AHCY,PFKFB3,TRIOBP,CFL1,HDAC2,TKT,CNR1,HNRNPAB,TPM3,FLOT1,CAPG,JUNB,MYL9,BCL2L1,ADRA2A,DUSP1,IL1RN,XRCC6,GAPDH,ALDOA,TFRC,MAP2K3,PHF1,C3AR1,UBE2I,S100A11,ADAM17,LEP,PRDX1,HN1,PCDHGB4,ADIPOQ,PPIA,FKBP1A,RUVBL1,FLNA,ANXA1,ANXA5,DUSP10,KIT,STIM1,HPGDS,ALPK2,P4HA2,CAPZB,TNFRSF1A,FCGR2A,ACTB,ALOX5AP,NFKBIZ,ENO1,FCER1G,FKBP4,PSAP,MMP9,ADRA1A	73	
Cell Death and Survival, Neurological Disease	cell death	cell death of cortical neurons	5.14E-05	 	-0.468	 	-0.741	UBQLN1,MAP1B,SH3GLB1,HIF1A,HSPA5,FAS,CTSD,GBA,PARK7,TCP1,GCLM,GSK3B,NFE2L2,UNG,PRNP,PLAT,TP63,TNFRSF1A,YWHAB,MAP3K1,CDK6,SOD1,HSPD1,APP,BCL2L1,CAPNS1,ADAM12,NTRK3,CDC42,DUSP1,IL1RN,MAPT,PEA15,GAPDH,MAP2K3	35	
Skeletal and Muscular System Development and Function	size	size of bone	5.16E-05	 	-0.563	 	-1.312	GAB2,CTGF,GPR55,PAX5,COMT,ATF4,GSK3B,SPP1,ACP2,MFAP5,CNR1,FGFR2,THRA,JUNB,KLF4,INPP4B,CD68,IL1RN,CD14,ESR2,SIRPA,PHLPP1,ADAM17,TFEB,SFRP2,LEP,MSR1,BTG3,PPIB,MMP14,LRP6,ADIPOQ,HEXA,GBA,EFNB1,HSD11B2,HCST,ALPL,PLXNA1,TYROBP,SOD1,CEBPB,CSF1R,CYP1B1,APP,ITGB2,FOS,MYOC,CSF1,FCER1G,SOX9,BMP6,MMP9	53	
Neurological Disease	seizure disorder	seizure disorder	5.18E-05	 	-1.890	bias	0.585	SOCS3,NCDN,MAP1B,CA5B,BAG3,CA12,C1QA,C1QB,TUBB,SLC9A1,NR2F1,PTPRC,CTSD,SRPX2,GLB1,ABCC1,STAM,CLCN3,STXBP1,CALCRL,ACP2,SV2B,PPP1R1B,CNR1,KCNK2,DGKE,RAPGEF3,JUNB,NPY5R,LMCD1,HSPA8,FOSB,SH3GL1,SLC25A22,DUSP1,IL1RN,MS4A4A,MAPT,MAPK10,CTSB,ME2,ATOX1,AARS,CYR61,ADCYAP1,SCN11A,MT-TP,EPHX1,APOE,LEP,DUSP6,PCDH19,HYOU1,ADIPOQ,HEXA,CD83,HMOX1,GBA,KCNMA1,SCN3A,LOC102724428/SIK1,MICALL1,ALPL,CRYM,NDUFS4,PLAT,SIGMAR1,TNFRSF1A,EGR1,ANOS1,GABBR1,CSTB,APP,SERPINE2,FOS,MT-ND5,ITPA,PPT1,NR4A1,TSPO,TPP1,PSAP,MMP9,ADRA1A,NCAM1	85	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	lipofuscinosis	lipofuscinosis	5.54E-05	 	 	 	 	GRN,CTSD,DNAJC5,PPT1,TPP1,CLCN7,CLN5,CLN6,ATP13A2	9	
Cell Morphology, Cellular Assembly and Organization	morphology	morphology of lysosome	5.54E-05	 	 	 	 	LAMP2,CTSA,ACP2,KIF5B,GAA,TPP1,NAGLU,ATP13A2,PRNP	9	
Carbohydrate Metabolism, Small Molecule Biochemistry	synthesis	synthesis of glycosaminoglycan	5.60E-05	 	1.144	bias	-0.408	ADCY2,B3GALT6,CTGF,SPP1,XYLT1,GCNT2,RAB10,HYAL1,ADIPOQ,HRAS,HEXA,CCND3,BSG,LTF,IL1RN,TGFB2,CHST11,GPC1,B3GAT3,SFRP1	20	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	hematological neoplasia	hematological neoplasia	5.61E-05	 	-1.646	 	-0.965	NPM1,SCFD2,KLHDC8B,WHSC1,PCLO,RRM2B,TIGIT,CTSG,NEXN,ODC1,CLIP1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,CSE1L,STAM,LSM3,GNA13,TMSB10/TMSB4X,MGAT1,UNG,ICT1,LAIR1,PPTC7,MSMO1,FGFR2,ANXA2,DCTD,CD52,DES,MYL9,CYP4B1,BTG2,DUSP4,ACTG1,ESR2,RPL41,SCN11A,STEAP3,EPHX1,NME1,PRDX1,CUBN,SEC23B,GDF15,DPM2,EEF1B2,ADIPOQ,PPIA,CRAT,SMARCA4,COL16A1,SERPINA1,SNRPD3,AMOT,FKBP3,SIGMAR1,PLOD2,RPL4,MECOM,MT-TY,TUBB4B,FCGR2A,RNF157,STON1,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,FAM129A,CCT7,RPL37,BMPER,ABCC3,BMP6,CSTF3,ID4,NUTF2,ADRA1A,EEF1A1,SLC25A43,TRAF3,SESN2,ARL6IP5,RABEP1,ZNF79,ACO2,RACK1,BAG3,MRPL47,HSPA5,C3orf17,NNMT,CD28,TMEM132C,SAE1,RPS13,HOXA7,ABCB11,STAB1,TUBA1C,MTMR2,ADAMTS5,NSMAF,PFKFB3,PSMB5,HDAC2,RERG,UROS,TMC5,SLC12A7,FYB,TXNRD1,BCL2L1,SDCBP,TLN2,SLC25A39,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,TFPI,CCPG1,TNS1,PPAT,UBE2I,RPSA,POLE3,IGFBP4,RAB4A,RPLP1,SRPX,MSR1,MECR,FAT3,ALAS1,MLH1,IRAK1,HLA-G,SHC1,COL6A1,F8,MCAM,PPP1R2,KLHL42,DNAAF1,LONP1,ATP13A2,MT-CO1,SLC20A1,MT-ATP6,TP63,TUBG1,NQO1,ST3GAL6,TRPA1,HSPD1,PSME3,ATIC,CXCL16,SCARA3,SLC33A1,PSMD2,MUC17,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,RAN,NCSTN,MKI67,RPS11,BBS1,RAD23A,CECR1,BCAT1,ZBTB7B,SGPL1,C9orf91,LRFN5,LGMN,PRG4,MPV17L2,PLCXD1,CTSS,GAA,ABCC1,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,CFL1,SLC24A3,TUBB2A,HMGA1,JUNB,ROR1,KIAA0100,CTPS1,SH3GL1,ACAD11,NUGGC,CCND2,CD68,DHRS9,C19orf53,CNTNAP4,STIP1,ARHGAP35,CCT3,MAP2K3,LRP8,TCF7,CYR61,SETBP1,GSTP1,ALK,SORL1,MSC,SLC24A2,ADAM17,RALA,NID2,PSMB10,HLA-A,LRP6,ST6GALNAC4,FKBP1A,KAZN,MACC1,LIPA,RPL35,LYZ,MYO5C,TTC7B,MT-CYB,SCN3A,ANXA5,TOP2A,STIM1,NPTXR,RPS12,LIMCH1,LAMB4,RPS24,MYH1,CCDC68,RPS19,SLC25A13,PTPRK,SYNGR2,IMPDH2,ACTB,EGR1,TRIM28,STXBP6,CYP1B1,STS,ITGB2,B4GALT2,PSME1,MRPL51,CLDN5,PDIA6,IMMT,UQCR10,USP22,BMF,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,CXCL12,TCEB2,VDAC2,CTBP1,PAX5,NARS,SLC29A3,SLC25A6,RPL13,DPP3,CDON,COMT,ANXA7,GSK3B,RET,COL27A1,DSP,EIF2AK1,SPP1,POLR1A,ANLN,PSMF1,CDK6,ST6GALNAC3,HIST1H2BK,ATP10A,MARS,RPL28,UBXN11,CD3G,IL1RN,SH2B3,CD14,GNL3,LFNG,STXBP5,CYP4A11,RPL13A,RNPEP,RBBP8,EPSTI1,HIF1A,FAS,ERV3-1,MPEG1,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,F5,KIT,SEMA3B,HCST,ASAP3,SHANK2,ALPL,PI4KB,ADAMTS15,CALR,COL5A2,TPST2,RARS2,MAP3K1,R3HDM1,CLEC9A,GABBR1,CEBPB,CSF1R,KIAA1683,ARHGEF10L,MT-ND5,PAG1,SLC16A1,EPHB3,UQCRC1,ADAM9,SEMA4B,SHMT2,ATP6V1B2,MMP9	369	
Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development	morphology	morphology of bone	5.72E-05	 	 	 	 	NAB2,HOXB5,GAB2,RGMA,CTGF,HOXA6,GPC3,SPRY4,GPR55,PTPRC,HS6ST1,CDON,HOXA10,ATF4,GSK3B,ZBTB16,KLF2,RFNG,SPP1,FST,ACP2,LMO4,MFAP5,SLC4A7,FGFR2,THRA,PYGO2,INPP4B,CD68,VKORC1,GPR65,PRKACA,NAGLU,CLCN7,LFNG,SFRP1,TFPI,MEGF8,ESR2,SLC4A4,SULF1,APOE,SLC4A2,SFRP2,MMP14,LRP6,ADIPOQ,HEXA,CFTR,CETN2,THBS1,EFNB1,TGFB2,NACC1,HCST,ALPL,SMPD3,PLXNA1,TP63,TYROBP,TNFRSF1A,EGR1,DVL1,CEBPB,PLXND1,CSF1R,FOS,ITGB2,LAMP2,KIF7,CSF1,PPT1,FCER1G,EPHB3,DVL3,SOX9,BMPER,BMP6,MMP9	79	
Cellular Compromise	disassembly	disassembly of filaments	5.73E-05	 	1.683	 	1.286	APOE,GEM,CFL1,EML4,DVL1,MAP1B,HRAS,PLXND1,FAS,APP,PLEKHH2,RHOD,PDXP,EFNB1,ABCC1,MAPT,LIMA1,MAPK10,MID1IP1,ARHGEF2,PLEK,GSK3B,PRNP,WDR1	24	
Cell Death and Survival	cell death	cell death of central nervous system cells	5.78E-05	 	-0.005	 	0.212	NPM1,MAP1B,CXCL12,SH3GLB1,HSPA5,CTSD,GCLM,GSK3B,UNG,PFKFB3,YWHAB,CDK6,JUNB,BCL2L1,ADAM12,CDC42,DUSP1,IL1RN,STIP1,MAPT,MAPK10,GAPDH,MAP2K3,ADCYAP1,APOE,LEP,DDIT3,UBQLN1,VAPA,HYOU1,HIF1A,FAS,GBA,PARK7,TCP1,RPS3,NFE2L2,ATP13A2,PRNP,PLAT,SRR,UCP2,TP63,TNFRSF1A,EGR1,MAP3K1,SOD1,HSPD1,APP,FOS,CAPNS1,NTRK3,PEA15,CYCS	54	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small-cell lung carcinoma	stage 1 non-small-cell lung carcinoma	5.88E-05	 	 	 	 	EEF1A1,NDUFB4,SEC61G,XPO5,PPIA,RNASE1,RPS11,FTL,ERBB4,EIF4A1,IFI30,CLCN3,TMSB10/TMSB4X,MYL12A	14	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of blood cells	5.98E-05	Increased	3.501	bias	1.380	GAB2,NPM1,MSR1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,GULP1,EIF2AK1,PTX3,CALR,UCP2,FCGR2A,RAPGEF3,CAPG,CEBPB,APP,ITGB2,CDC42,TREM2,FCER1G,CD14,PLAU,IRF8,SIRPA	32	
Cancer, Organismal Injury and Abnormalities	breast or colorectal cancer	breast or colorectal cancer	6.06E-05	 	0.754	 	0.683	ADAMTS8,PCLO,PPP1R14B,SPRY4,GPR55,GNB1,POR,ALPK3,CCND3,CSE1L,DGKG,GNA13,AIF1,KNSTRN,SYT17,AHCY,HCFC1R1,SRPRA,ANXA2,RCC2,CTSB,ALCAM,C15orf39,NHLH1,KDM1B,FTH1,EIF3K,EPHX1,HTATIP2,GBP1,DAPK2,PRDX1,BAG6,ADIPOQ,PPIA,MFSD5,SMARCA4,SYNM,RABL6,ALPK2,AMOT,MTSS1L,PLOD2,MECOM,TUBB4B,FCGR2A,RNF157,PVR,RNF6,MYO5A,MARCKSL1,MTHFD1L,AFF3,EDIL3,KIF7,NR4A1,SOX9,BTBD2,AKR1C3,SEPT9,DPM1,EML4,AP1B1,GPC3,CBX5,CTSD,OSCP1,CCT5,TUBA1C,ADAMTS5,NSMAF,HDAC2,STK39,UROS,CBX6,FYB,GUF1,BCL2L1,ADRA2A,RBX1,SLC7A2,LSM1,TMX2,TFPI,CBX3,TNS1,SULF1,IGFBP4,ZC3H7B,DDX21,PLGRKT,FLRT1,PCDHGB4,FAT3,ZNF219,ALAS1,PKHD1L1,HLA-G,COL6A1,F8,IGSF8,DNAAF1,LASP1,MT-CO1,PATL1,TP63,AKR1C1/AKR1C2,TRIM55,SOD1,TXNDC12,FECH,SLC25A5,MAP4K4,TUBA1B,THEMIS2,CPAMD8,CTGF,GYG2,MKI67,ZBTB7B,DUSP3,PRG4,MPV17L2,PXK,KIF21A,PNKD,KLF8,BIRC7,CAPN6,SV2B,CENPB,PTP4A3,DKC1,CNOT10,MALSU1,JUNB,ROR1,BCAP29,NGRN,FARSA,ISLR,FNDC1,C19orf53,SNRNP25,RMND1,RTN4,ARHGAP35,CCT3,B3GNT5,SETBP1,GSTP1,SORL1,GSTM5,BTG3,HLA-A,NQO2,FKBP1A,RUVBL1,CCAR2,H2AFZ,CDH11,ENAH,NDUFB9,CES1,PHB,UST,MT-CYB,PGAM1,DCXR,TRIM16,TUB,MYO1D,HPGDS,FKBP5,SMPD3,SLC30A1,GJB2,LIMCH1,LAMB4,RPS24,PLXNA1,CD209,NAP1L4,NOL6,ANKRD9,PTPRK,EGR1,TRIM28,ZFY,PAICS,COPS3,STS,CALM1 (includes others),CLIC6,HIST1H1E,GLIS2,SREBF1,NCAM1,CLUH,RGMA,PLCB2,PFN1,HIST1H2BC,KCND3,CD4,MYH15,MAP1B,SLC27A4,METAP2,CNDP2,GSPT1,SLC25A6,DPP3,CDON,COMT,RPL19,GPC1,C1QBP,RET,MDH2,COL27A1,DSP,PCNXL2,C7orf50,TRIOBP,FST,GSDMB,HSPA9,LAGE3,IRX6,MAGED2,DGKE,SLC4A7,ATP10A,SLC39A3,CD3G,RARRES3,NUAK1,CLCN7,YIF1A,CYP4A11,AKR7A2,SH3RF3,SFRP2,KIAA1191,HIGD1A,ATF5,PCDH19,ILF2,MRPS30,CLCN4,SLC39A1,THBS1,ERBB4,HSPE1,MAPKAPK2,ASAP3,OGDH,ADAMTS15,CALR,TPST2,HSPH1,MAP3K1,RNF43,VSIG4,SZRD1,GUK1,CEBPB,SYNPO2,PLXND1,THRSP,EMP1,P4HA1,PAG1,CYC1,APOC1,ASAP2,GBE1,NUCB2,C6,ADAM9,PPP2R1B,HLTF,PSG2,KLHDC8B,WHSC1,CTSG,KCMF1,COL8A1,NEXN,PLEKHM2,SLC9A1,ODC1,CLIP1,FADS3,PTPRC,IP6K3,GATAD2A,LTF,EIF4G2,KEAP1,SPTB,PLEKHO2,CEP170B,ATF4,GNG12,UNG,ALDOC,MRPL24,ALDH1B1,MFAP5,PPP1R1B,CNR1,FGFR2,NPY5R,DES,NDN,HAX1,NRBP1,HSPA8,PYGO2,CTSA,SCUBE1,FSCN1,BTG2,PSMA5,GPR65,TFRC,DUSP4,SQSTM1,ESR2,SCN11A,STEAP3,APOE,NME1,PLXNA3,SLC4A2,CDH18,CUBN,GDF15,HSPB8,EEF1B2,LGALS9,CRAT,PROX1,TECR,ATRAID,MMP25,SDK1,GRINA,COL16A1,CCT4,ACTR3,HSP90AB1,TNXB,PLIN2,ATP5J2,DAB2,ALG8,NFE2L2,RPL4,TMC2,GLRX2,GNA12,SLC6A6,STON1,SLC39A6,ZNF362,LZTS2,TRIB3,C1orf122,HSPA2,CPEB4,FOS,MT-ND1,NTRK3,FLNC,EIF4A1,DOPEY2,ARHGDIA,BTF3L4,BMPER,BMP6,SIM1,ABCC3,CSTF3,ADRA1A,SESN2,MBP,ACO2,NME2,TYMP,MRVI1,NPC1L1,CD28,FAM117B,CXCL14,PACS2,HOXA10,FAR2,STAB1,CDC42EP1,GCLM,CHMP1A,PFKFB3,FSTL3,C20orf27,RILPL1,TNPO1,LAMA2,KCNK2,TMC5,EIF2B3,SLC12A7,CAPG,PGAP3,CITED1,KLF4,DMXL2,SLC3A2,FOSB,KCNG1,ADAM12,MATN2,DUSP1,LIMA1,IGFBP3,UHRF1BP1L,MEGF8,POLE3,ERAP2,RAB4A,SRPX,SCARA5,MECR,TMEM60,SLC38A1,MLH1,REXO2,SHC1,TWF2,MED15,MCAM,PPP1R2,FAM166A,LOC102724428/SIK1,RHOBTB2,RPS3,IARS,LONP1,LIAS,WDR1,SLC20A1,PSAT1,VCAM1,EDNRB,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,ST3GAL6,TRPA1,HSPD1,NFE2L1,SERPINE2,FGF1,SHB,CLGN,KIF5B,NOP16,MUC17,IVD,CHI3L1,CADM3,APOB,C9orf72,MMEL1,LDB3,HRAS,NCSTN,VWA5A,CECR1,BCAT1,ABR,GAA,ABCC1,WNT5B,CALCRL,RIMS3,CFL1,THSD4,SLC24A3,TKT,GSTM3,TUBB2A,ZNF592,AASS,PDRG1,NR1H3,KIAA0100,NUGGC,CCND2,CD68,DHRS9,BSG,CNTNAP4,MS4A4A,LMOD2,STIP1,MBD4,IL10RA,ALDOA,GLUL,MAP2K3,LRP8,CDK2AP2,SFRP1,AIDA,TCF7,CYR61,MYEOV,ALK,MSC,SLC24A2,ADAM17,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,CDK16,HMGN1,XPOT,PFKL,TTC1,DCLK1,TAX1BP3,FANCE,MACC1,C1QTNF3,RPL35,GBA,IFRD2,SRGAP1,SLC2A6,TBC1D12,HLCS,TOP2A,SNX10,PRKCE,STIM1,PSMD14,TPO,ZNF70,COX4I1,PLOD3,PLAT,RPS19,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,ATXN2L,STXBP6,CYP1B1,POMGNT1,EIF3G,FIS1,B4GALT2,COL5A3,CLDN5,SREBF2,DOCK8,PPP1R16B,ARAP1,CYCS,DVL3,CBX4,PLAU,MAPRE3,MVD,GAB2,SLC7A11,PTPN23,VPS28,MRPL54,CXCL12,UTP4,MMRN1,TUBB,MTCH2,VDAC2,NR2F1,PAX5,RAB11FIP2,SDAD1,EIF5,ITGAV,SLC7A5,SIAH2,CLCN3,PTX3,EIF2AK1,IGFBP6,TBC1D2B,KLHL11,SPP1,SGCG,SNRPF,MACROD1,GCNT2,CDK6,PSMC4,ST6GALNAC3,MARS,PKN1,TIE1,SEL1L,EFS,PPP2R1A,PLEKHH2,MAPK10,VDAC1,AKR1B1,PHF1,B3GALT6,LEP,EPB41L3,PRDX5,PDGFA,MMP14,PKM,RBBP8,UGCG,SLC7A1,CFTR,HIF1A,GANAB,FAS,TACR1,SOX17,HMOX1,CCDC88A,NLK,CSPG4,KCNMA1,NDUFC2,FLNA,ANXA1,EFNB1,F5,TGFB2,GSTM4,KIT,TCP1,HSD11B2,ARHGEF2,HCST,ALPL,HMGCS1,PI4KB,PRNP,TRAF7,NDUFAF3,SEMA3E,ADCY2,DLGAP4,TAF6,C10orf71,GABBR1,QSOX1,ZBTB7C,NFASC,CSF1R,SLC5A3,ARHGEF10L,ENO1,MT-ND5,LPAR1,DIP2C,SLC16A1,OLFML2B,TANGO2,ZNF117,CLDN2,MAT2A,SLC27A3,USP9Y,RTN3,SCAND1,CARM1,SHMT2,ATP6V1B2,MMP9	696	
Carbohydrate Metabolism	hydrolysis	hydrolysis of polysaccharide	6.09E-05	Increased	2.000	bias	1.317	CTSD,LYZ,LEP,CTSG	4	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of L-glutamine	6.09E-05	 	 	 	 	SLC1A4,SLC1A5,SLC38A1,SLC38A3	4	
Cellular Function and Maintenance	function	function of antigen presenting cells	6.09E-05	 	 	 	 	APOE,MSR1,PYCARD,MMP14,UNC5B,GDF15,TIGIT,CXCL12,PPIA,IRAK1,LGMN,CSPG4,CTSS,TGFB2,CYBB,IFI30,CLCN3,PLAT,PLXNA1,SIGMAR1,CD209,LCP1,SPP1,UCP2,TYROBP,TNFRSF1A,FCGR2A,NPY1R,EGR1,CAPG,CEBPB,CSF1R,GRN,FOS,MARCKSL1,CSF1,DOCK8,TREM2,FCER1G,CD14,PSAP,DUSP4,PLAU,CHI3L1,SIRPA,MMP9	46	
Post-Translational Modification, Protein Degradation, Protein Synthesis	molecular cleavage	molecular cleavage of protein fragment	6.09E-05	 	1.098	 	0.136	APOE,SPCS1,CSTA,ADAM17,TRAF3,CMA1,BAG6,MMP14,CTSG,NCSTN,FAS,OGT,CTSD,CNDP2,LGMN,F8,DPP3,CTSS,FBXW11,TRABD2A,F5,CHMP1A,LONP1,CLN6,PLAT,PSMB5,HDAC2,PSMC4,AURKAIP1,NR1H3,CPA3,DNAJC1,CSTB,SERPINE2,HSPA8,BCL2L1,CTSA,CAPNS1,CTSB,TPP1,CAPN2,PLAU,SFRP1,ADAM9,MMP9,RNPEP	46	
Cardiovascular System Development and Function, Cellular Movement	cell movement	cell movement of endothelial cells	6.21E-05	Increased	2.057	bias	-0.377	CTGF,CXCL12,HRAS,SDC4,HSPA5,CD63,SPRY4,CXCL14,ITGAV,STAB1,CDC42EP1,GSK3B,GPC1,TMSB10/TMSB4X,KLF2,SPP1,PTP4A3,DGKE,ANXA2,THRA,TARS,CDC42,RTN4,IGFBP3,ALCAM,MAP2K3,CYR61,TFPI,CD151,APOE,LEP,MMP14,PKM,ADIPOQ,PROX1,HIF1A,TNFRSF12A,LIPA,HSP90AB1,FLNA,THBS1,CSPG4,MCAM,SAA1,TGFB2,PRKCE,CSNK2B,MAPKAPK2,AMOT,NFE2L2,SEMA3E,PLXNA1,VCAM1,PLXND1,CYP1B1,FGF1,GRN,ITGB2,WARS,EDIL3,NR4A1,PLAU,BMP6,MMP9	64	
Cellular Movement	migration	migration of breast cancer cell lines	6.23E-05	Increased	3.479	bias	1.410	GAB2,NME1,CTGF,LEP,SEPT9,ARF1,OSGIN1,MMP14,RACK1,CXCL12,HRAS,RUVBL1,SDC4,HIF1A,GRINA,ENAH,SHC1,ARF6,CCDC88A,CSE1L,FLNA,ANXA1,MCAM,ITGAV,LASP1,NDUFAF3,PLXNA1,SPP1,BHLHE41,FGFR2,ANXA2,ROR1,KLF4,FGF1,SDCBP,ADAM12,CDC42,IGFBP3,WBP2,CAPN2,PLAU,BMP6,TFPI,ADAM9,MAP4K4,ESR2,MMP9,UBE2I	48	
Organismal Injury and Abnormalities, Renal and Urological Disease	chronic kidney disease	chronic kidney disease	6.27E-05	Decreased	-2.157	bias	 	MVD,APOE,NPM1,SLC7A11,APOB,RPL36A,UQCRH,MMP14,CA5B,CA12,EEF1B2,ADIPOQ,FKBP1A,GSS,NDUFA1,APRT,LGMN,PHB,TUBA1C,LSM3,AIF1,ATP5I,ALPL,MT-CO1,SIGMAR1,PSMB5,SPP1,SGCG,TNFRSF1A,IMPDH2,FCGR2A,TUBB4B,TUBG1,TUBB2A,PFDN5,JUNB,KLF4,GLIS2,VKORC1,PSMD2,NDUFA6,NAGLU,P2RY12,TFPI,CD151	45	
Molecular Transport	secretion	secretion of molecule	6.32E-05	Increased	2.065	bias	-0.163	SOCS3,TRAF3,APOB,ARF1,CTSG,CXCL12,HRAS,HSPA5,PANX1,EXPH5,PTPRC,PTGES2,PNKD,NEO1,ABCB11,GNA13,RET,STXBP1,ACSL3,FST,CNR1,NR1H3,RAPGEF3,ANXA2,THRA,HMGA1,NPY5R,RPH3A,FOSB,SEL1L,ERP29,ADRA2A,CDC42,IL1RN,CD300C,RTN4,CD14,UHMK1,PLTP,ADCYAP1,ESR2,C3AR1,SIRPA,STEAP3,SLC4A4,SORL1,SCD,APOE,SLC4A2,LEP,SEC23B,PKM,ADIPOQ,PPIA,CFTR,FAS,TACR1,C1QTNF3,HMOX1,ARF6,CES1,PHB,THBS1,ANXA1,PLIN2,SAA1,TGFB2,LY6E,PRKCE,SMPD3,SLC30A1,CYP27A1,NPY1R,FCGR2A,EGR1,AP3D1,DVL1,CLEC9A,SYT11,GABBR1,DNAJC1,SOD1,SNCG,STXBP6,FGF1,APP,CIDEA,SREBF1,PPT1,FCER1G,NUCB2,P2RY12,ABCC3,BMP6,ADAM9	95	
Carbohydrate Metabolism	glycolysis	glycolysis of cells	6.41E-05	 	0.776	bias	-0.336	SLC4A4,PFN1,PFKFB1,PKM,LRP6,HIF1A,PFKL,SHC1,OGT,BCAT1,ENTPD5,PGAM1,C1QBP,GSK3B,MAPKAPK2,HK1,PFKFB3,TP63,KLF4,ENO1,CISD1,INPP4B,BSG,GAPDH,ALDOA	25	
Cellular Assembly and Organization	quantity	quantity of lipid droplets	6.49E-05	 	1.006	 	0.679	SULF1,SIGMAR1,SRA1,PLIN1,SLC31A1,LEP,PPP1R3C,ADIPOQ,AUP1,ARSA,KPNA1,MAFG,CTBP1,CES1,AAK1,ADAMTS5,CTDNEP1	17	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	transmigration	transmigration of phagocytes	6.65E-05	Increased	3.392	bias	2.030	CD209,VCAM1,ADAM17,TNFRSF1A,MMP14,CXCL12,PVR,NINJ1,APP,ITGB2,DOCK8,CDC42,CTSS,CSF1,MCAM,ITGAV,RTN4,STAB1,SIRPA,MMP9	20	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of macrophages	6.80E-05	 	1.986	bias	0.203	NAB2,NPM1,SPP1,TYROBP,ADIPOQ,CXCL12,HIF1A,CSF1R,PLXND1,NINJ1,TNFAIP8L2,IL1RN,FLNA,CSF1,TREM2,SH2B3,CYBB,STAB1,PLAU,MAPKAPK2,PRNP	21	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of myeloid cells	6.84E-05	Increased	2.236	bias	1.442	APOE,PLCB2,MSR1,PYCARD,UNC5B,GDF15,ADIPOQ,CXCL12,PPIA,G6PC3,IRAK1,HLA-G,LGMN,CSPG4,TGFB2,CYBB,CLCN3,PLAT,SIGMAR1,LCP1,SPP1,UCP2,TNFRSF1A,TYROBP,NPY1R,FCGR2A,EGR1,CAPG,CEBPB,CSF1R,GRN,FOS,ITGB2,MARCKSL1,CSF1,TREM2,FASTK,FCER1G,CD14,PSAP,DUSP4,PLAU,C3AR1,SIRPA,MMP9	45	
Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Emery-Dreifuss muscular dystrophy	Emery-Dreifuss muscular dystrophy	7.00E-05	 	 	 	 	S100A11,PLOD2,FHL1,COL5A2,CFL1,TUBB2A,EMD,HIF1A,SDC3,TAX1BP3,COL6A1,SDCBP,SERPINH1,IFI30,DAB2,TMEM43	16	
Cellular Function and Maintenance	engulfment	engulfment of antigen presenting cells	7.14E-05	Increased	3.592	bias	1.612	GAB2,NPM1,MSR1,HYOU1,BIN1,FAS,PTPRC,HMOX1,THBS1,SAA1,ANXA1,MAPKAPK2,EIF2AK1,PTX3,CD209,CALR,UCP2,FCGR2A,RAPGEF3,PGAP3,CAPG,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,SIRPA	28	
Cell Morphology, Cellular Assembly and Organization	abnormal morphology	abnormal morphology of lysosome	7.15E-05	 	 	 	 	LAMP2,CTSA,ACP2,KIF5B,GAA,TPP1,NAGLU,ATP13A2	8	
Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function	proliferation	proliferation of mononuclear leukocytes	7.20E-05	Increased	2.107	 	0.602	NPM1,CTGF,MAF,TIGIT,NCSTN,PTPRC,ZBTB7B,LTF,CCND3,ST6GALNAC2,STAM,TXN,AIF1,ZBTB16,LCP1,LAIR1,HMGA1,JUNB,CTPS1,HSPA8,CCND2,BSG,CD300C,PRKACA,IL10RA,B3GNT5,TCF7,ADCYAP1,GSTP1,APOE,LAPTM5,PSMB10,ADIPOQ,LGALS9,PPIA,FKBP1A,SMARCA4,ARF6,PRKCE,SERPINA1,STIM1,TPO,HPGDS,IL11RA,CD209,TYROBP,TNFRSF1A,IMPDH2,FCGR2A,EGR1,FOS,ITGB2,FTL,DOCK8,CSF1,FCER1G,PEA15,ARHGDIA,PLAU,GAB2,SOCS3,TRAF3,PLCB2,PLP1,CD4,MBP,CXCL12,HSPA5,CD28,CTSD,RHOG,HOXA10,GSK3B,C1QBP,KLF2,SPP1,CDK6,FYB,KLF4,PKN1,SLC3A2,BCL2L1,CD3G,EFS,CDC42,DUSP1,IL1RN,SH2B3,CD14,PIK3AP1,IRF8,PPAT,CD151,LEP,PYCARD,KLRD1,CD83,HIF1A,FAS,HLA-G,TACR1,HMOX1,SHC1,DKK3,THBS1,ANXA1,DUSP10,EFNB1,TGFB2,KIT,PRNP,CALR,VCAM1,NPY1R,MAP3K1,MGAT5,VSIG4,HSPD1,CEBPB,IL20RB,CSF1R,SHB,PAG1,NCKAP1L,MMP9	125	
Cellular Assembly and Organization	fusion	fusion of liposome	7.27E-05	 	0.570	bias	-0.413	APOE,STXBP1,ANXA1,ANXA2,STXBP5,APP	6	
Cell Death and Survival	apoptosis	apoptosis of colorectal cancer cell lines	7.45E-05	 	-1.500	 	-1.419	PSG2,ADAM17,LEP,DDIT3,DAPK2,PYCARD,COX8A,GDF15,PKM,BAG3,PPIA,HRAS,FAS,MLH1,CTBP1,HINT1,RABL6,AHSA1,G0S2,PARK7,CSE1L,ITGAV,GSK3B,TMSB10/TMSB4X,NFE2L2,BIRC7,SPP1,HDAC2,PPP1R1B,CNR1,HSPD1,BCL2L1,NTRK3,CDC42,LIMS1,USP22,ATMIN,IGFBP3,CYCS,SOX9,IRF8,SQSTM1,PHF1,GSTP1,PHLPP1	45	
Cell-To-Cell Signaling and Interaction	response	response of tumor cell lines	7.49E-05	Increased	2.907	bias	1.553	TRAF3,PFN1,RALA,CLIP1,HMOX1,CTSD,ARF6,RHOG,ANXA1,TOP2A,GSTM4,PRKCE,GNA13,KLF2,PTX3,CALR,TP63,FCGR2A,TNPO1,GNA12,CLTC,FGFR2,RAPGEF3,ROR1,FGF1,BCL2L1,CDC42,TREM2,CTSB,GAPDH,SIRPA,ALK	32	
Cancer, Organismal Injury and Abnormalities	adenocarcinoma	adenocarcinoma	7.58E-05	 	-1.327	 	-0.579	PCLO,VAC14,LRRN4CL,EEF1G,GNB1,GLB1,VIT,DEFB132,GNA13,DCAF12,SYT17,RNPEPL1,SRPRA,ANXA2,PLAG1,MYL9,RCC2,CD300C,NDUFB7,PSMA4,ALCAM,ELMO2,ACTG1,RCN3,KDM1B,FHL1,GBP1,SLC1A5,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,AMOT,MTSS1L,RNF157,PSMB6,MARCKSL1,AFF3,EDIL3,KIF7,ATP6V1F,DERL1,GCSH,NR4A1,WBP2,RPL37,BTBD2,PIGU,AKR1C3,EML4,DIRAS1,DNAJC15,CBX5,LHFPL2,HS6ST1,ANKDD1A,ABCB11,SNRPD1,TUBA1C,NSMAF,WDR93,ARRDC2,UBL4A,GUF1,BCL2L1,RPL8,RBX1,LSM1,NAGLU,TMX2,CBX3,POLD2,ETV5,SCD,ZC3H7B,SUMO3,CARS,FLRT1,FAT3,PKHD1L1,EIF2S1,MARVELD1,COL6A1,F8,GID4,C16orf59,IGSF8,DNAAF1,LASP1,SEC61G,NDUFB4,AKR1C1/AKR1C2,SNTB1,PYGB,UTY,VAT1,TXNDC12,FECH,SLC25A5,MAP4K4,C15orf59,RPLP0,RAP2B,GFPT1,CTGF,FAM19A5,ITGA8,CA12,ABCC6,ZBTB7B,SGPL1,LRFN5,SLC22A15,PRG4,ZNF605,FAM124B,PXK,PNKD,GPR26,ZBTB16,BIRC7,SV2B,CENPB,PTP4A3,CNOT10,MALSU1,NINJ1,SH3GL1,ACAD11,ISLR,SNRNP25,NCLN,RMND1,ARHGAP35,FKBP14,SORL1,HLA-A,NQO2,LRP6,ST6GALNAC4,FKBP1A,CCAR2,MRPL30,SDC3,RNF185,CADM2,MYO5C,UST,MT-CYB,SCN3A,DIP2B,TUB,TXNL1,HPGDS,RPS5,SMPD3,GJB2,LIMCH1,RPS24,NAP1L4,CD209,SLC25A13,RRP1B,EGR1,ZFY,COPS3,STS,CALM1 (includes others),C8orf33,ATXN10,AOX1,NCAM1,CLUH,RGMA,PDZD11,ZBTB47,SLC27A4,FAM173A,PLCXD3,CNDP2,PTGES2,PLCE1,DPP3,COMT,CHST11,PGP,AAGAB,COL27A1,SLC6A8,FST,ACP2,POLR1A,CLTC,ANKMY2,IRX6,MAGED2,SLC4A7,ATP10A,SLC39A3,TARS,TMEM189,YIF1A,CYP4A11,UTP11,AKR7A2,FPR3,GEM,PCDHAC2,PCDH19,FLYWCH2,CLCN4,SSU72,HINT1,THBS1,DUSP10,CYGB,ASAP3,TMEM104,TPST2,SZRD1,CEBPB,SYNPO2,ANO2,PLCB4,PAG1,RPS27L,NCKAP1L,HLTF,MPV17,SLC47A1,CSTA,SCFD2,IGSF6,PCDHAC1,KCMF1,CLSTN2,SLC35C1,PANX1,ODC1,NPL,GATAD2A,LTF,SRPX2,HIGD2A,COMMD2,SPTB,PLEKHO2,STAM,GNG12,ALDOC,MRPL24,ALDH1B1,ICT1,MFAP5,CNR1,RPAP3,DCTD,SMOC2,DES,PXDC1,HAX1,SPATA20,NRBP1,PYGO2,SCUBE1,MRNIP,AACS,CYP4B1,GCC1,TFRC,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,MRPL37,FKBP2,APOE,NME1,AASDHPPT,PLXNA3,FBXO10,SLC4A2,CDH18,ARL4C,CUBN,HN1,SEC23B,HS2ST1,ZDHHC11B,EEF1B2,LGALS9,CRAT,PROX1,COPS8,TECR,SDK1,CCT4,OGT,HSP90AB1,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ALG8,SERPINA1,SNRPD3,NFE2L2,RPN1,P4HA2,RPL4,MED20,MLF2,GLRX2,GNA12,FUCA2,SLC6A6,DGAT2,SLC39A6,STON1,YPEL1,LZTS2,THAP11,SNCG,C1orf122,CPEB4,TBC1D13,MYOC,NTRK3,SERPINH1,EIF4A1,TPP1,C6orf62,BTF3L4,BMPER,BMP6,SIM1,PPIL1,ADRA1A,BZW2,NCDN,TPPP3,MEGF9,USP5,TMEM8A,SLC41A3,PPFIBP2,ACO2,BAG3,NME2,MRPL47,TYMP,IMP4,CES2,SLC35F6,MRVI1,C3orf17,MRM2,BIN1,NNMT,CD28,TMEM132C,SAE1,MOCOS,CXCL14,PACS2,HOXA7,STAB1,DPM3,GULP1,PFKFB3,RILPL1,TNPO1,CNP,TMC5,SLC12A7,THRA,CMSS1,PSMD3,ARSA,TRIM35,DNAJC5,TLN2,ADAM12,MATN2,ALDH1A2,UHRF1BP1L,CCPG1,TMEM176B,POLE3,CALHM2,PTGFR,ERAP2,RAB4A,SLC1A4,SRPX,SCARA5,AUP1,SLC38A1,VPS4A,RAP1GDS1,FYTTD1,DNAJC4,MED15,MCAM,ZNF483,ACAD8,LOC102724428/SIK1,RHOBTB2,IARS,ATP13A2,WDR1,FAM171B,SLC20A1,VCAM1,ECHDC2,AGFG1,EDNRB,DCTN3,MGAT5,ST3GAL6,HSPD1,PSME3,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,KCTD13,CLGN,HMBOX1,SLC33A1,PSMD2,MAF,PCDH7,C1QB,VWA5A,KPNA1,MUC7,CHST2,BCAT1,DYNLL1,ABR,ABCC1,HADHB,RIMS3,ZNF592,NR1H3,TSPAN33,ZNF414,PCK1,CLN5,KIAA0100,MRPL14,NUGGC,DHRS9,MS4A7,IL10RA,ALDOA,P2RY8,LRP8,CDK2AP2,AIDA,FH,SLC35A4,PHLPP1,SLC4A4,ALDH4A1,ATP5G1,RALA,TMEM129,CDK16,CTNNA1,ACSF2,SP2,MACC1,SRGAP1,ANXA5,TBC1D12,PRKCE,NACC1,RPS12,SARS,YIPF2,PLOD3,PLAT,RPS19,C9orf142,URB1,ATXN2L,STXBP6,POMGNT1,ITGB2,MRPL51,COL5A3,CLDN5,DOCK8,UQCR10,PRMT5,P2RY12,MAPRE3,MVD,GAB2,PLP1,PTPN23,VPS28,MRPL54,PAX5,SDAD1,CYBB,SIAH2,LPIN2,ADPRHL2,CLCN3,TBC1D2B,KLHL11,SPP1,SGCG,GPS2,ANLN,MACROD1,ERH,PSMC4,MARS,EIF2S2,RPL9,UBE2D2,PLEKHH2,IL1RN,HSPA13,STXBP5,AKR1B1,PHF1,RNPEP,SPX,B3GALT6,LEP,MMP14,FAM47E,GANAB,SLFN5,FLNA,NLGN4Y,GSTM4,SENP3,PSMA3,RBM18,BHMT2,UBA5,SEMA3E,TMEM126B,FRMD1,ADCY2,DLGAP4,C10orf71,CENPV,RARS2,AP3D1,F13A1,CCDC58,MKNK2,CSF1R,ARHGEF10L,ENO1,ITPA,SLC16A1,OLFML2B,TANGO2,PANK3,CLDN2,CARM1,SHMT2,ATP6V1B2,MMP9,NPM1,ADAMTS8,REM1,NPAS2,PPP1R14B,SPRY4,GPR55,ALPK3,CCND3,ATG9A,CSE1L,DGKG,AIF1,KNSTRN,AHCY,SLC2A5,HCFC1R1,SURF1,FBXO8,PRKACA,CTSB,C15orf39,PLTP,ADCYAP1,FTH1,EIF3K,EPHX1,EVA1B,HTATIP2,ARPC1B,PSMD7,DAPK2,PRDX1,BAG6,DPM2,COL15A1,SMARCA4,AAK1,PLOD2,UCP2,MECOM,TUBB4B,PTRH1,SLC25A1,SPATS2L,RNF6,MYO5A,CSF1,SEPHS1,SOX9,C1orf123,SDF4,PCDH18,SEPT9,RABEP1,DPM1,SCN7A,SLC9A9,AP1B1,GPC3,CTSD,OSCP1,CCT5,UQCRFS1,ERAL1,FNDC4,ADAMTS5,NAGA,STXBP1,SESN3,HDAC2,STK39,UROS,CBX6,MAPK8IP2,CREG1,FIG4,FYB,EIF4E2,SMPD2,TXNRD1,OLA1,ADRA2A,SLC7A2,TFPI,TNS1,SULF1,IGFBP4,DDX21,LITAF,F2RL3,PLGRKT,PCDHGB4,HABP4,ZNF219,ALAS1,PHLDB2,FILIP1,FARSB,HLA-G,GTPBP2,RPL18A,CRYM,PATL1,TP63,TRIM55,TRIM2,KIF3B,APLP2,WIPF3,POLR3B,CPAMD8,THEMIS2,HOXA6,RAN,GHITM,GYG2,MKI67,GSS,EXPH5,BBS1,RAD23A,AHSA1,LGMN,DUSP3,MPV17L2,POU6F2,KIF21A,MGAT4B,MED16,SYT2,AFAP1,TESK1,CAPN6,DKC1,DPY19L1,CPNE4,ELOVL1,JUNB,ROR1,COPB1,BCAP29,NGRN,FARSA,INPP4B,FNDC1,RTN4,CCT3,B3GNT5,SETBP1,GSTP1,KLHL18,GSTM5,BTG3,TMEM11,TTLL4,HYOU1,SDCCAG3,CDH11,ENAH,LYZ,CES1,TTC7B,PGAM1,DCXR,TRIM16,MYO1D,NPTXR,SLC30A1,LAMB4,PLXNA1,DDX3Y,NOL6,PTPRK,LPCAT4,CSRNP2,TIAL1,CASK,SNTG2,CLIC6,HIST1H1E,IMMT,GLIS2,BRINP2,RHBDD2,SREBF1,USP22,NAB2,PLCB2,HIST1H2BC,C8orf82,KCND3,PRMT3,CD4,MYH15,UNC5B,MAP1B,TCEB2,CD63,METAP2,GSPT1,CAMK2D,SLC25A6,CDON,LYNX1,ALDH3A2,PCYT2,POMP,ANXA7,GSK3B,GPC1,PHPT1,RET,BCKDK,DSP,PCNXL2,C7orf50,MRPS15,MFSD3,HK1,FERMT3,SLC4A5,ACSL3,THUMPD3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,DGKE,GPAA1,UBXN11,CD3G,SH2B3,TMEM176A,MAPT,RARRES3,NUAK1,CD14,CLCN7,LFNG,DNPEP,ARL2,SPIRE1,SRM,CNRIP1,SH3RF3,TOLLIP,RAB1A,KIAA1191,ATF5,ILF2,MRPS30,RRAGD,ERBB4,HSPE1,MAPKAPK2,KCTD1,OGDH,SHANK2,ADAMTS15,COL5A2,BHLHE41,HSPH1,MAP3K1,RNF43,R3HDM1,OAF,VSIG4,GUK1,PLXND1,KIAA1683,PLBD2,C2orf88,TMEM2,CYC1,ASAP2,EPHB3,GBE1,NUCB2,C6,ADAM9,SEMA4B,GRPEL1,PSG2,KLHDC8B,WHSC1,LRRC59,TIGIT,CTSG,COL8A1,C1QC,MNAT1,PLEKHM2,NEXN,SLC9A1,CLIP1,FADS3,PTPRC,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,CEP170B,ATF4,LMX1A,LCP1,UXS1,PPP1R1B,PPTC7,FGFR2,TIMM8B,FLOT1,NPY5R,NDN,HSPA8,TMEM127,CTSA,FBXW5,TOMM22,FSCN1,GPR65,PRELP,ATMIN,SLC35B4,TMEM33,SCN11A,STEAP3,PPDPF,CHCHD10,OSGIN1,PHLDA2,HSPB8,MMP25,G6PC3,GRINA,COL16A1,ACTR3,SORBS1,FAM102A,OSBPL11,TTC23,CSNK2B,RPP25L,STT3B,TMC2,SRA1,TNFRSF1A,ZNF362,TRIB3,HSPA2,SPTLC3,FOS,MT-ND1,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,DOPEY2,CCT7,TSC22D2,ABCC3,C11orf68,CSTF3,SIGLEC6,PPIP5K2,ICMT,SESN2,MBP,RACK1,OGFOD1,STARD7,HSPA5,NPC1L1,FAM117B,MEGF6,FAR2,CDC42EP1,GCLM,LACTB,BCAS2,YWHAB,GM2A,LAMA2,SRPRB,KCNK2,HNRNPAB,EIF2B3,RAPGEF3,CAPG,PGAP3,CITED1,KLF4,KCTD15,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,NDUFA6,SLC25A39,CDH20,LIMA1,IGFBP3,CAPN2,MRPS2,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,MSR1,COPE,LEO1,TMEM60,HNRNPK,MLH1,RPL14,SHC1,SLC19A3,TWF2,PREPL,PPP1R2,KIAA0232,SAA1,TRABD2A,FAM166A,RNH1,UBIAD1,LONP1,LIAS,CAPZB,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NDUFV3,NQO1,TRPA1,LARP6,NRBF2,PDAP1,SHB,CIDEA,SCARA3,KIF5B,NOP16,SLC36A1,TTL,MUC17,GXYLT2,FHL5,NR6A1,CADM3,KCNK15,SLC29A4,APOB,C9orf72,AHCYL1,SGSH,MMEL1,LDB3,TXNL4A,MARK1,HRAS,NCSTN,CECR1,PEG10,GAA,ANAPC11,WNT5B,CALCRL,THSD4,SLC24A3,TKT,TUBB2A,FAM126B,AASS,CTPS1,CCND2,NR1D1,CD68,BSG,CNTNAP4,LMOD2,STIP1,MBD4,ADM2,GLUL,MAP2K3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,ALK,ENOPH1,S100A11,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,NID2,UBQLN1,DUSP6,HMGN1,XPOT,ADAP2,TTC1,DCLK1,RNF24,FANCE,UCHL1,C1QTNF3,SEC61A1,SLC2A6,HLCS,TOP2A,SNX10,SAMD1,ACAP2,STIM1,TPO,ZNF70,AMFR,COX4I1,NDUFS4,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,FGD6,CYP1B1,AREL1,APP,EIF3G,WARS2,FIS1,B4GALT2,SUPV3L1,PDIA6,SREBF2,PPP1R16B,ADCY1,ARAP1,NR5A2,DVL3,CBX4,PLAU,SLC38A11,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,CXCL12,UTP4,MMRN1,SDC4,TAF10,TUBB,VDAC2,CTBP1,RAB11FIP2,SLC29A3,PUSL1,ITGAV,NEO1,SLC7A5,EIF2AK1,IGFBP6,C6orf132,DNASE2,GCNT2,CDK6,RAB10,ST6GALNAC3,PKN1,EPRS,TIE1,LMCD1,SEL1L,PPP2R1A,ADCYAP1R1,ATP6V0D1,GNL3,VDAC1,JTB,TMOD1,RPL13A,CEACAM21,RNF165,EPB41L3,KLRD1,VAPA,PKM,RBBP8,UGCG,SLC7A1,CFTR,LDLRAD3,HIF1A,STXBP4,NAA10,FAS,EVC,TACR1,SOX17,HMOX1,CCDC88A,NLK,CSPG4,NDUFC2,KCNMA1,ANXA1,EFNB1,F5,TGFB2,KIT,TCP1,ARHGEF2,SELENOH,NR2F6,HCST,ALPL,STK40,HMGCS1,PI4KB,ACTN1,PRNP,TRAF7,CYP27A1,NXPH4,GABBR1,QSOX1,ZBTB7C,NFASC,NFKBIZ,SLC5A3,KIAA0930,WARS,MT-ND5,DIP2C,LPAR1,ZNF117,SLC27A3,USP9Y,RTN3	1234	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of macrophages	7.60E-05	 	-0.453	 	-1.318	PTX3,APOE,SPP1,PFN1,CXCL12,SOD1,FAS,FGF1,GRN,CD28,HMOX1,TNFAIP8L2,THBS1,CSF1,IL1RN,NR4A1,PLAU,C6,PLAT	19	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of actin cytoskeleton	7.65E-05	 	1.308	bias	0.139	ADAMTS8,ARF1,ARPC5,SH3BGRL3,CXCL12,RAN,HRAS,DYNLL1,RHOG,ABR,AFAP1,TMSB10/TMSB4X,RET,LCP1,CFL1,MLST8,SLC3A2,ADAM12,ADRA2A,CDC42,FSCN1,GPR65,ALDOA,SFRP1,PLEK,SIRPA,SPIRE1,LEP,RALA,PDGFA,ENAH,SHC1,CCDC88A,ARF6,TWF2,FLNA,RHOD,SORBS1,EFNB1,ANXA1,TGFB2,KIT,ARHGEF2,AMOT,ACTN1,WDR1,PRNP,CALR,MGAT5,KCTD13,FLNC,ARAP1,ARHGDIA,PLAU,NCKAP1L,RUFY3	56	
Hereditary Disorder, Organismal Injury and Abnormalities	autosomal dominant disease	autosomal dominant disease	7.66E-05	 	-1.897	bias	 	APOB,C9orf72,RRM2B,MAF,LDB3,GARS,HRAS,ODC1,GNB1,SGPL1,CCND3,KIF1A,CHCHD2,CFL1,TUBB2A,TPM3,FGFR2,SMOC2,HAX1,CCND2,MBD4,TMEM43,AARS,SQSTM1,FH,SETBP1,ACTG1,DEAF1,ESR2,STEAP3,SCN11A,FTH1,S100A11,APOE,CHCHD10,LRP6,HSPB8,FKBP1A,SDC3,TAX1BP3,SMARCA4,UCHL1,DAB2,TUB,STIM1,GJB2,PLOD2,TNFRSF1A,ACTB,APP,GRN,CALM1 (includes others),FTL,FLNC,SERPINH1,ATXN10,CYCS,ARHGDIA,SOX9,SIM1,TRAF3,KCND3,BAG3,TUBB,PAX5,NR2F1,PLCE1,IFI30,RET,DSP,ANLN,GCNT2,CDK6,THRA,SDHC,PPP2R1A,DNAJC5,SDCBP,MAPT,XRCC6,SH2B3,CLCN7,PIK3AP1,IRF8,CNBP,RPSA,FAT3,HIF1A,EVC,COL6A1,PARK7,ERBB4,MT-TS1,KIT,NSMF,CRYM,ACTN1,PRNP,MT-CO1,COL5A2,TP63,TUBG1,DVL1,RAB7A,TRPA1,SOD1,HSPD1,CSF1R,PLCB4,ITPA,SLC33A1,SLC16A1	112	
Cell Morphology, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development, Tissue Morphology	abnormal morphology	abnormal morphology of osteoclasts	7.73E-05	 	 	 	 	PTPRC,GAB2,SLC4A2,INPP4B,CD68,TYROBP,ADIPOQ,CLCN7,CEBPB,CSF1R,GPR55	11	
Molecular Transport, Protein Trafficking	nuclear export	nuclear export of protein	7.73E-05	 	 	 	 	CALR,AHCYL1,CSE1L,HSPA9,RAN,XPO5,EIF5A,UHMK1,GSK3B,NUTF2,XPO6	11	
Connective Tissue Development and Function, Skeletal and Muscular System Development and Function	resorption	resorption of bone	7.77E-05	 	1.488	 	0.697	GAB2,NCDN,LEP,LRP6,ADIPOQ,ATP6AP1,GPR55,DYNLL1,LGMN,LTF,CTSS,ITGAV,GSK3B,CSNK2B,SPP1,TYROBP,TNFRSF1A,EGR1,RAB7A,CEBPB,CSF1R,CYP1B1,INPP4B,CD68,ADAM12,LPAR1,CDC42,CSF1,IL1RN,GPR65,FCER1G,TPP1,TFRC,CLCN7	34	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	oral squamous cell carcinoma	oral squamous cell carcinoma	7.84E-05	 	 	 	 	SULF1,CSTA,NPM1,CTGF,CDH18,FAM19A5,ITGA8,PKM,CXCL12,PCDH7,CD83,GPC3,COL15A1,HSP90AB1,RAB38,ERBB4,CXCL14,TUBA1C,IGFBP6,PLOD2,MFAP5,TUBB4B,TUBG1,TUBB2A,HAX1,FGF1,EDIL3,ADAM12,LPAR1,MATN2,IL1RN,IGFBP3,CHI3L1,ADAM9,TMEM176B	35	
Cell Death and Survival	apoptosis	apoptosis of heart	7.86E-05	 	-0.022	 	0.840	SOCS3,SCD,SFRP2,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,S100A1,CALR,CALCRL,SPP1,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A	37	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of leukocytes	7.88E-05	Increased	3.494	bias	1.367	GAB2,NPM1,MSR1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,EIF2AK1,PTX3,CALR,UCP2,FCGR2A,RAPGEF3,CAPG,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,PLAU,IRF8,SIRPA	30	
Organismal Injury and Abnormalities	nodule	nodule	7.91E-05	 	-1.481	 	-1.870	CALR,SPP1,LEP,CTGF,DDIT3,PRDX5,APP,MT-ND1,MT-ND5,HSP90AB1,PARK7,ANXA5,IGFBP3,CTSB,TPO,BMP6,GSTP1	17	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	autosomal dominant myopathy	autosomal dominant myopathy	7.99E-05	 	 	 	 	S100A11,PLOD2,COL5A2,CFL1,TUBB2A,RAB7A,BAG3,HSPB8,GARS,HIF1A,SDC3,TAX1BP3,SDCBP,COL6A1,FLNC,SERPINH1,IFI30,DAB2,TMEM43,STIM1,AARS	21	
Connective Tissue Disorders, Developmental Disorder, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	exencephaly	exencephaly	8.04E-05	Decreased	-4.334	bias	 	CALR,RGMA,APOB,RALA,LMO4,CFL1,BAG6,LRP6,DVL1,FKBP1A,ROR1,KIF3B,SMARCA4,POR,PYGO2,MARCKSL1,BCL2L1,MTHFD1L,KIF7,LPAR1,PRKACA,ATMIN,ARHGAP35,BMPER,MEGF8,DEAF1	26	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of phagocytes	8.26E-05	 	1.593	bias	-0.690	APOE,GAB2,ADAM17,APOB,LEP,PLGRKT,PYCARD,CD4,CXCL12,ADIPOQ,CTSG,GPC3,CD28,LYZ,LTF,THBS1,ANXA1,NFE2L2,PTX3,FERMT3,VCAM1,UCP2,SPP1,TNFRSF1A,FCGR2A,MGAT5,ST3GAL6,ALOX5AP,F13A1,FLOT1,CSF1R,CYP1B1,APP,ITGB2,EDIL3,IL1RN,CSF1,RTN4,CD14,MAP2K3,SFRP1,CYR61,TFPI,CHI3L1,ADCYAP1,C3AR1,MMP9	47	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis of brain	8.38E-05	 	0.730	 	0.999	APOE,MAPT,PPT1,ADIPOQ,SH3GLB1,CLCN7,GSK3B,HPGDS,APP	9	
Carbohydrate Metabolism, Energy Production	metabolism	metabolism of pyruvic acid	8.38E-05	 	0.594	bias	-0.352	SRR,IL1RN,SLC16A1,PKM,NQO1,ALDOA,ME2,HOGA1,PCK1	9	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of lymphocytes	8.44E-05	 	1.639	bias	-1.049	MAF,HRAS,SLC35C1,CHST2,PTPRC,SGPL1,ZBTB7B,LGMN,CCND3,CTSS,ST6GALNAC2,STAM,GNA13,APEX2,CALCRL,LAIR1,DKC1,FGFR2,HAX1,IL10RA,B3GNT5,ADCYAP1,ESR2,C3AR1,GSTP1,SLC4A4,APOE,DDIT3,PSMB10,HLA-A,PRDX1,NQO2,ADIPOQ,PPIA,SMARCA4,SORBS1,TYROBP,TNFRSF1A,IMPDH2,FCGR2A,GNA12,EGR1,SLC6A6,APP,FOS,ITGB2,DOCK8,CSF1,BMF,FCER1G,NR4A1,PSAP,ARHGDIA,PLAU,SOCS3,TRAF3,PLP1,CD4,MBP,BAG3,CXCL12,STARD7,PAX5,CD28,CTSD,COMT,STAB1,SPP1,DNASE2,GCNT2,LAMA2,CDK6,THRA,FYB,KLF4,PKN1,FOSB,BCL2L1,CD3G,XRCC6,SH2B3,IGFBP3,PIK3AP1,IRF8,SIRPA,LEP,PYCARD,CD83,HIF1A,FAS,IRAK1,HLA-G,SHC1,DKK3,THBS1,DUSP10,SAA1,EFNB1,KIT,HCST,PRNP,VCAM1,CYP27A1,NPY1R,NQO1,ST3GAL6,VSIG4,SOD1,CEBPB,PSME3,IL20RB,CSF1R,CXCL16,TNFAIP8L2,SLC33A1,PAG1,CHI3L1,MMP9,CARM1	119	
Cellular Function and Maintenance, Tissue Development	function	function of connective tissue cells	8.44E-05	 	 	 	 	APOE,SFRP2,SLC4A2,CTGF,SLC1A5,MMP14,ADIPOQ,GPR55,PTPRC,NACC1,TXN,GSK3B,HCST,ALPL,SPP1,TYROBP,FGFR2,THRA,CEBPB,PIR,CD68,CSF1,FCER1G,CLCN7,CHI3L1	25	
Cell Death and Survival	cell death	cell death of epithelial cells	8.55E-05	 	-0.039	 	-0.563	NPM1,SOCS3,CD4,UNC5B,HRAS,TMBIM6,HSPA5,SGPL1,DYNLL1,CTSS,ENTPD5,CDON,ABCC1,MCOLN3,ITGAV,GSK3B,HK1,SPP1,CDK6,SDHC,HAX1,BCL2L1,CDC42,IL1RN,MAPT,IGFBP3,CTSB,GAPDH,TFRC,SFRP1,VDAC1,ESR2,CD151,SCD,LEP,DDIT3,PYCARD,NQO2,GDF15,HSPB8,CTNNA1,ADIPOQ,UGCG,FAS,TACR1,HMOX1,SHC1,SAA1,AAK1,DAB2,MAPKAPK2,NFE2L2,ATP13A2,PLAT,PRNP,SLC20A1,CALR,TP63,MECOM,TNFRSF1A,EGR1,MAP3K1,TRIB3,SOD1,HSPD1,CEBPB,CSF1R,FGF1,APP,RBCK1,EMP1,FOS,MYOC,TNFAIP8L2,GLIS2,NTRK3,BMF,PEA15,NR4A1,FKBP4,CYCS,PLAU,SLC25A5,BMP6,SLC47A1	85	
Cell-To-Cell Signaling and Interaction	response	response of antigen presenting cells	8.60E-05	Increased	3.669	bias	1.638	GAB2,NPM1,SOCS3,CXCL12,BIN1,FAS,G6PC3,IRAK1,PTPRC,HMOX1,PARK7,THBS1,CTSS,ANXA1,SAA1,PRKCE,MAPKAPK2,EIF2AK1,PTX3,CALR,UCP2,HDAC2,FCGR2A,CLEC9A,RAPGEF3,CAPG,CEBPB,CMC2,APP,ITGB2,CD68,TREM2,FCER1G,IL10RA,RARRES3,CD14,IRF8,SIRPA	38	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	familial amyloidosis	familial amyloidosis	8.91E-05	 	 	 	 	SORL1,APOE,LIPA,CTSD,MT-ND1,MAPT,APOC1,MAPK10,RET,MMP9,PRNP,APP	12	
Molecular Transport	release	release of metal	9.01E-05	Increased	2.524	bias	0.706	S100A11,FPR3,RAB32,LEP,DDIT3,AHCYL1,CD4,RACK1,CXCL12,FKBP1A,TMBIM6,FAS,GPR55,PTPRC,CD28,ANXA1,PACS2,CYBB,ITGAV,PRKCE,STIM1,HCST,BCAP31,SLC30A1,NFE2L2,PRNP,S100A1,CALR,SPP1,LMO4,FCGR2A,DVL1,SOD1,CSF1R,NDN,APP,MYO5A,BCL2L1,CSF1,FCER1G,P2RY12	41	
Cell Morphology, Cellular Function and Maintenance	autophagy	autophagy of cells	9.25E-05	Increased	2.496	 	1.551	ICMT,SESN2,CD4,CXCL12,BAG3,SH3GLB1,HSPA5,PLCE1,GAA,NUPR1,ATF4,GSK3B,RAPGEF3,BCL2L1,SQSTM1,TBC1D16,PAFAH1B2,SCD,TFEB,RAB1A,DDIT3,DAPK2,BAG6,PKM,ADIPOQ,HSPB8,FKBP1A,HIF1A,EIF2S1,FAS,HMOX1,GBA,SERPINA1,STIM1,NACC1,NFE2L2,PRNP,LETM1,NQO1,RAB7A,QSOX1,TRIB3,SOD1,CEBPB,POLDIP2,APP,CISD1,CAPNS1,SERPINH1,BMF,COX5A,TBC1D7	52	
Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development	abnormal morphology	abnormal morphology of bone	9.29E-05	 	 	 	 	NAB2,HOXB5,GAB2,RGMA,CTGF,HOXA6,GPC3,SPRY4,GPR55,PTPRC,HS6ST1,CDON,HOXA10,ATF4,GSK3B,ZBTB16,KLF2,RFNG,SPP1,FST,ACP2,LMO4,MFAP5,SLC4A7,FGFR2,THRA,PYGO2,INPP4B,CD68,VKORC1,PRKACA,NAGLU,CLCN7,LFNG,SFRP1,TFPI,MEGF8,ESR2,SLC4A4,SULF1,APOE,SLC4A2,SFRP2,MMP14,ADIPOQ,HEXA,CFTR,CETN2,EFNB1,TGFB2,NACC1,HCST,ALPL,SMPD3,PLXNA1,TP63,TYROBP,TNFRSF1A,EGR1,DVL1,CEBPB,PLXND1,CSF1R,FOS,ITGB2,LAMP2,KIF7,CSF1,PPT1,FCER1G,EPHB3,DVL3,SOX9,BMPER,BMP6,MMP9	76	
Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance	formation	formation of lamellipodia	9.35E-05	Increased	3.037	bias	1.072	CTGF,ADIPOQ,CXCL12,HRAS,SDC4,PHLDB2,TNFRSF12A,CCDC88A,ARF6,ACTR3,RHOG,TWF2,RHOD,DKK3,KIT,DGKG,C1QBP,RET,LASP1,FERMT3,LCP1,CAPZB,CFL1,MAP3K1,PVR,FGF1,BSG,LPAR1,CDC42,FSCN1,PLAU,CYR61	32	
Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders	high bone mass disease	high bone mass disease	9.60E-05	Decreased	-2.384	bias	 	FERMT3,GAB2,SLC4A2,TYROBP,CSF1R,OSTM1,FOS,CSF1,FCER1G,SNX10,CLCN7,GSK3B,SQSTM1,HCST,ESR2,ALPL,MMP9	17	
Cellular Movement	cell movement	cell movement of tumor cells	9.62E-05	Increased	4.046	bias	2.282	GAB2,LEP,SFRP2,CTGF,MMP14,ADIPOQ,CXCL12,HRAS,SMARCA4,THBS1,MCAM,TGFB2,HOXA7,PRKCE,RHOBTB2,SIAH2,RET,ZBTB16,VCAM1,SPP1,TP63,GNA12,MAP3K1,RAPGEF3,KLF4,CSF1R,CDC42,CSF1,DUSP1,CTSB,ALCAM,SFRP1,PLAU,ESR2,SIRPA,MMP9	36	
Cellular Function and Maintenance, Hematological System Development and Function, Inflammatory Response	engulfment	engulfment by macrophages	9.66E-05	Increased	3.353	bias	1.581	PTX3,EIF2AK1,CALR,GAB2,NPM1,UCP2,FCGR2A,CAPG,PGAP3,RAPGEF3,CEBPB,BIN1,FAS,APP,PTPRC,HMOX1,ITGB2,THBS1,ANXA1,SAA1,TREM2,FCER1G,CD14,MAPKAPK2,SIRPA	25	
Connective Tissue Development and Function, Tissue Morphology	quantity	quantity of adipose tissue	9.67E-05	Increased	2.566	 	1.089	SOCS3,GFPT1,APOB,PLIN1,BAG3,EIF6,HSPA5,COMT,CXCL14,UBL5,CNR1,TKT,NR1H3,RAPGEF3,THRA,PCK1,ADAM12,ADRA2A,DUSP1,CD14,SQSTM1,SFRP1,ADCYAP1,ESR2,APOE,SCD,LEP,GDF15,ADIPOQ,SDC3,LIPA,CES1,NLK,CSPG4,PHYH,PLIN2,PRKCE,ALPL,RAD23B,UCP2,TRIM55,NPY1R,NQO1,DGAT2,CEBPB,COL5A3,CIDEA,LPAR1,SREBF1,PLAU,SIM1	51	
Carbohydrate Metabolism, Small Molecule Biochemistry	molecular cleavage	molecular cleavage of proteoglycan	9.68E-05	Increased	2.236	bias	 	CTSD,LYZ,MMP14,CTSG,MMP9	5	
Carbohydrate Metabolism, Small Molecule Biochemistry	synthesis	synthesis of glycerol	9.68E-05	 	 	 	 	LEP,DGAT2,GOT1,PGP,PCK1	5	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of glutamine	9.68E-05	 	 	 	 	CD28,SLC1A4,SLC1A5,SLC38A1,SLC38A3	5	
Cellular Function and Maintenance, Hematological System Development and Function	engulfment	engulfment of myeloid cells	9.94E-05	Increased	3.790	bias	1.598	GAB2,NPM1,MSR1,HYOU1,BIN1,FAS,PTPRC,HMOX1,THBS1,ANXA1,SAA1,STIM1,CLCN3,MAPKAPK2,EIF2AK1,PTX3,CALR,UCP2,FCGR2A,RAPGEF3,CAPG,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,PLAU,IRF8,SIRPA	30	
Cellular Movement, Skeletal and Muscular System Development and Function	migration	migration of smooth muscle cells	9.94E-05	 	0.061	bias	-1.546	IGFBP4,APOE,FHL1,LEP,ADIPOQ,PPIA,SDC4,HMOX1,CAMK2D,THBS1,NEO1,TXN,GSK3B,MAPKAPK2,NFE2L2,PLAT,CALCRL,SPP1,EGR1,NQO1,CDK6,ALOX5AP,CYP1B1,LPAR1,DUSP1,RTN4,PLAU,CYR61,TFPI,MMP9	30	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of carcinoma cell lines	1.00E-04	 	0.249	 	-0.595	CTGF,SLC7A11,CXCL12,HRAS,CD28,SLC25A6,CCND3,KEAP1,AAGAB,C1QBP,RET,ZBTB16,KLF2,HK1,SPP1,TUBB2A,FGFR2,CREG1,ANXA2,THRA,ROR1,SLC3A2,MYL9,BSG,FSCN1,IGFBP3,GAPDH,SFRP1,CYR61,ALK,SCD,ADAM17,LEP,EPB41L3,ATF5,PDGFA,OSGIN1,MMP14,GDF15,PKM,ADIPOQ,PROX1,HIF1A,ASNS,SMARCA4,UCHL1,HMOX1,SLFN5,CSPG4,ANXA1,ERBB4,LOC102724428/SIK1,DAB2,PRKCE,SEMA3B,NFE2L2,HSPB6,VCAM1,TP63,TNFRSF1A,TRIM28,EGR1,DVL1,SOD1,DEGS1,GRN,EMP1,TMEM2,NR4A1,TSPO,PLAU,NCAM1	72	
Organismal Development	abnormal morphology	abnormal morphology of body cavity	1.03E-04	 	 	 	 	NR6A1,PLIN1,CTGF,RRM2B,ITGA8,NCSTN,SLC35C1,KPNA1,APRT,PTPRC,POR,LGMN,CCND3,GAA,PLIN5,ATF4,GNA13,UNG,CALCRL,CENPB,FGFR2,NR1H3,TSPAN33,HMGA1,PCK1,DES,PYGO2,CTSA,CCND2,BSG,ATMIN,ARHGAP35,B3GNT5,C3AR1,ESR2,STEAP3,SLC4A4,APOE,ADAM17,SLC4A2,PRDX1,BAG6,LRP6,GDF15,HSPB8,ADIPOQ,FKBP1A,HEXA,LIPA,ARF6,CES1,GBA,LY6E,PRKCE,DAB2,NFE2L2,SMPD3,MECOM,TNFRSF1A,EGR1,SLC6A6,LZTS2,TIAL1,COPS3,GRN,FOS,ITGB2,LAMP2,GLIS2,NTRK3,CSF1,LIMS1,BMF,PPT1,FCER1G,FKBP4,NR5A2,PSAP,ARHGDIA,DVL3,SOX9,BMPER,PLAU,SGCD,SOCS3,DAD1,CD4,SDC4,NPC1L1,GPC3,BIN1,CEBPG,SLC27A4,CD28,CTSD,HS6ST1,PLCE1,COMT,ENTPD5,HOXA10,CYBB,ITGAV,NUPR1,HOXA7,ABCB11,ANXA7,GSK3B,RET,CLCN3,KLF2,PTX3,EIF2AK1,SPP1,DNASE2,FSTL3,SGCG,HDAC2,MAPK8IP2,CDK6,PHB2,RAPGEF3,THRA,KLF4,TIE1,ADAM12,IL1RN,DUSP1,SH2B3,XRCC6,ALDH1A2,IGFBP3,NAGLU,CAPN2,LFNG,H1F0,IRF8,AKR1B1,MEGF8,TNS1,RPSA,CD151,IGFBP4,MSR1,SRPX,PDGFA,PYCARD,MMP14,CFTR,HIF1A,FAS,MLH1,SHC1,HMOX1,SLC19A3,THBS1,FLNA,TGFB2,EGLN3,HSD11B2,HCST,ALPL,LASP1,RAD23B,SLC20A1,CALR,VCAM1,TP63,EDNRB,TRIM55,NPY1R,MAP3K1,NQO1,HYAL1,EMD,SOD1,CEBPB,NFKBIZ,CSF1R,KIF3B,PLXND1,NFE2L1,TNFAIP8L2,ITPA,EPHB3,GBE1,ADAM9,CARM1,MMP9	188	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of connective tissue cells	1.04E-04	Increased	2.251	bias	0.481	CTGF,SLC4A2,WHSC1,CD4,CXCL12,HRAS,SDC4,CDH11,CD28,RHOD,ITGAV,TMEM123,CALR,VCAM1,SPP1,MECOM,MAP3K1,CLTC,MGAT5,ANXA2,THRA,PLXND1,APP,OSTM1,TLN2,MYOC,ADAM12,CDC42,CSF1,PLAU,CYR61,TMOD1	32	
Cellular Movement, Skeletal and Muscular System Development and Function	cell movement	cell movement of smooth muscle cells	1.04E-04	 	0.255	bias	-1.341	IGFBP4,APOE,FHL1,LEP,ADIPOQ,PPIA,SDC4,HMOX1,CAMK2D,THBS1,NEO1,TXN,GSK3B,MAPKAPK2,NFE2L2,PLAT,CALCRL,SPP1,EGR1,NQO1,CDK6,ALOX5AP,CYP1B1,LPAR1,CDC42,CSF1,DUSP1,RTN4,PLAU,CYR61,TFPI,MMP9	32	
Inflammatory Response	inflammation	inflammation of organ	1.04E-04	 	-0.169	 	2.012	CA5B,TIGIT,C1QA,ODC1,POR,PTPRC,LTF,ATF4,AHCY,CNR1,TPM3,FGFR2,FLOT1,MYL9,CTSB,ALCAM,GAPDH,SQSTM1,ESR2,APOE,USP18,DDIT3,PRDX1,HN1,ADIPOQ,PPIA,LGALS9,NFE2L2,P4HA2,SIGMAR1,FCGR2A,TUBB4B,TNFRSF1A,DGAT2,CSF1,PPT1,NR4A1,PSAP,ARHGDIA,ADRA1A,SOCS3,EEF1A1,TRAF3,MBP,ACO2,TYMP,STARD7,GPC3,HSPA5,CD28,HS6ST1,CTSD,ENTPD5,STAB1,ABCB11,TUBA1C,PSMB5,HDAC2,KCNK2,HNRNPAB,RAPGEF3,CAPG,KLF4,BCL2L1,ADRA2A,DUSP1,XRCC6,IGFBP3,NAGLU,TFPI,TNS1,CD151,POLE3,UBE2I,SCD,F2RL3,PYCARD,SCARA5,PCDHGB4,IRAK1,SLC19A3,SHC1,F8,STUB1,MCAM,VCAM1,CAPZB,TP63,EDNRB,TUBG1,NQO1,MGAT5,SOD1,NFE2L1,CXCL16,SLC33A1,PSMD2,APOB,PLIN1,CA12,NCSTN,MKI67,APRT,SGPL1,LGMN,CTSS,GAA,PNKD,CFL1,TKT,TUBB2A,JUNB,NINJ1,BSG,IL10RA,ALDOA,MAP2K3,CYR61,C3AR1,GSTP1,S100A11,ADAM17,HLA-A,NQO2,LRP6,FKBP1A,RUVBL1,ASNS,CDH11,UCHL1,LIPA,PHB,MT-CYB,ANXA5,TOP2A,PRKCE,STIM1,HPGDS,IL11RA,PLAT,IMPDH2,TYROBP,EGR1,ACTB,APP,ITGB2,GLIS2,SREBF2,TREM2,BMF,FKBP4,FCER1G,P2RY12,NR5A2,PLAU,PLP1,CD4,CXCL12,TUBB,VDAC2,NR2F1,IFI30,CYBB,NEO1,ANXA7,RET,SPP1,TRIOBP,PKN1,EFS,IL1RN,MAPT,CD14,PHF1,LEP,PKM,CFTR,HIF1A,FAS,TNFRSF12A,HMOX1,FLNA,THBS1,PHYH,DUSP10,ANXA1,F5,KIT,MAPKAPK2,HCST,CALR,MAP3K1,GABBR1,CEBPB,NFKBIZ,CSF1R,ENO1,TNFAIP8L2,C6,MMP9	200	
Cell Death and Survival	cell death	cell death of liver	1.05E-04	Decreased	-2.171	 	-1.171	SCD,APOE,SOCS3,DDIT3,ADIPOQ,HRAS,UGCG,FKBP1A,TMBIM6,TAF10,FAS,PTPRC,TACR1,SLC19A3,HMOX1,SHC1,ARF6,FLNA,ENTPD5,SAA1,ITGAV,GSK3B,NFE2L2,SLC20A1,TYROBP,TNFRSF1A,SOD1,HSPD1,CEBPB,NFE2L1,APP,RBCK1,FOS,ITGB2,BCL2L1,LAMP2,IL1RN,SERPINH1,BMF,CTSB,CD14,DUSP4,IRF8,SLC25A5,MMP9	45	
Post-Translational Modification, Protein Degradation, Protein Synthesis	hydrolysis	hydrolysis of protein	1.05E-04	 	0.771	 	0.393	SPCS1,CSTA,ADAM17,TRAF3,CMA1,BAG6,MMP14,CTSG,NCSTN,SDC4,PTPRC,OGT,CTSD,CNDP2,LGMN,F8,DPP3,CTSS,FBXW11,TRABD2A,F5,CHMP1A,LONP1,CLN6,PLAT,PSMB5,ADRM1,HDAC2,PSMC4,AURKAIP1,NR1H3,CPA3,DNAJC1,CSTB,SERPINE2,HSPA8,CTSA,CAPNS1,CTSB,TPP1,CAPN2,SFRP1,ADAM9,MMP9,RNPEP	45	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of macrophages	1.05E-04	 	1.318	bias	-0.182	APOE,GAB2,VCAM1,UCP2,APOB,SPP1,PLGRKT,CXCL12,ADIPOQ,GPC3,CSF1R,APP,ITGB2,THBS1,IL1RN,CSF1,ANXA1,CYR61,TFPI,ADCYAP1,NFE2L2,C3AR1,MMP9	23	
Cellular Movement	migration	migration of connective tissue cells	1.06E-04	Increased	3.386	bias	1.744	APOE,CTGF,SLC4A2,LEP,RACK1,ADIPOQ,SDC4,SGPL1,LTF,THBS1,RHOD,KCNMA1,PRKCE,CYGB,GNA13,MAPKAPK2,SEMA3E,CALCRL,SPP1,ACTB,GNA12,TMEM201,MAP3K1,RAPGEF3,CSF1R,FGF1,CXCL16,CAPNS1,CDC42,CSF1,LIMA1,PRKACA,ARHGAP35,PLAU,CYR61,TNS1	36	
Cell Death and Survival, Neurological Disease	cell death	cell death of hippocampal cells	1.09E-04	 	0.308	 	0.630	APOE,UCP2,LEP,DDIT3,VAPA,HYOU1,JUNB,FAS,APP,CTSD,NTRK3,STIP1,MAPK10,CYCS,GSK3B,RPS3,ADCYAP1,ATP13A2,UNG,PLAT,PRNP	21	
Cell Death and Survival, Skeletal and Muscular Disorders	necrosis	necrosis of muscle	1.10E-04	 	-0.719	 	0.486	EEF1A1,SOCS3,CXCL12,CTSG,HRAS,MKI67,MNAT1,CAMK2D,CYBB,GSK3B,DSP,HK1,CALCRL,SPP1,HDAC2,SGCG,FSTL3,LAMA2,NDN,PKN1,BCL2L1,MTPN,ADAM12,IL1RN,RTN4,GAPDH,ALDOA,MAP2K3,CYR61,RPSA,LEP,DDIT3,DUSP6,ADIPOQ,HSPB8,HIF1A,FAS,IRAK1,SHC1,HMOX1,COL6A1,PARK7,PHB,STUB1,HSPE1,KIT,MAPKAPK2,HSPB6,PLAT,S100A1,CALR,PPIF,TNFRSF1A,MAP3K1,HSPD1,CSF1R,APP,LIMS1,CYCS,SGCD,ADRA1A	61	
Free Radical Scavenging	modification	modification of reactive oxygen species	1.14E-04	Increased	2.765	bias	 	PRDX1,PRDX5,NQO1,CYGB,CYCS,SOD1,TXN,APP	8	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	pigmented villonodular synovitis	pigmented villonodular synovitis	1.14E-04	 	 	 	 	C14orf2,FTL,LCP1,SPP1,ARFGAP1,KIT,RET,CSF1R	8	
Cell Death and Survival	necrosis	necrosis of brain cancer cell lines	1.14E-04	 	-1.052	 	-0.946	UNC5B,PKM,HRAS,KAZN,HIF1A,FAS,CSPG4,ERBB4,HOXA7,EGLN3,PRKCE,ATF4,PRNP,CALR,SEC61G,SPP1,PTPRQ,TNFRSF1A,CNR1,ANXA2,SOD1,APP,BCL2L1,CCND2,RBX1,MAPT,PRMT5,IGFBP3,SIRPA,MMP9,FTH1	31	
Cardiovascular System Development and Function, Organ Morphology, Organismal Development	morphology	morphology of heart ventricle	1.16E-04	 	 	 	 	APOE,ADAM17,APOB,PDGFA,ADIPOQ,HSPB8,FKBP1A,HIF1A,BIN1,POR,HMOX1,SHC1,PLCE1,CCND3,THBS1,GAA,ERBB4,TGFB2,PLIN5,LY6E,GNG5,CALR,VCAM1,HDAC2,SGCG,SLC6A6,MAP3K1,DES,BCL2L1,CCND2,ADAM12,NTRK3,MEGF8,ADAM9,SGCD,ESR2,MMP9	37	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Hematological System Development and Function, Inflammatory Response	phagocytosis	phagocytosis by macrophages	1.16E-04	Increased	3.231	bias	1.516	EIF2AK1,PTX3,CALR,NPM1,GAB2,UCP2,FCGR2A,RAPGEF3,CAPG,CEBPB,BIN1,FAS,APP,PTPRC,ITGB2,HMOX1,THBS1,TREM2,ANXA1,SAA1,FCER1G,CD14,MAPKAPK2,SIRPA	24	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	uptake	uptake of glutamine family amino acid	1.17E-04	 	1.035	bias	-0.089	SLC7A11,LEP,SLC1A5,ERBB4,SLC36A1,SLC7A2,SLC7A1,GLUL,ADCYAP1,FH,SLC38A3,SLC3A2	12	
Cell Death and Survival	cell death	cell death of phagocytes	1.21E-04	 	-0.077	 	-0.329	APOE,ADAM17,LEP,DDIT3,MSR1,PYCARD,RAN,CXCL12,C1QA,HIF1A,FAS,IRAK1,HMOX1,LYZ,HSP90AB1,LTF,ANXA1,CYBB,PRKCE,GSK3B,NFE2L2,PLAT,TNFRSF1A,CNR1,CEBPB,TPSAB1/TPSB2,APP,FOS,ITGB2,BCL2L1,CSF1,IL1RN,FCER1G,NR4A1,CTSB,CD14,MAP2K3,PIK3AP1,IRF8,C3AR1	40	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of cervical cancer cell lines	1.23E-04	 	0.074	 	-1.242	DDX21,LEP,OSGIN1,HSPB8,HRAS,COPS8,TUBB,SMARCA4,UCHL1,POR,CTBP1,CCDC88A,NAA38,DKK3,EIF5,TCP1,TXN,CSNK2B,PFKFB3,SEC61G,SPP1,TP63,GSDMB,FSTL3,MECOM,USMG5,ACTB,TUBB2A,NABP1,FGFR2,TRIM35,SMPD2,NDUFA13,FOS,IMMT,BSG,DVL3,TBC1D7,FTH1	39	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	intestinal adenoma	intestinal adenoma	1.26E-04	 	0.975	bias	1.723	SLC4A4,S100A11,KCND3,EPB41L3,SCARA5,NTMT1,CA12,ADIPOQ,RUVBL1,CES2,MLH1,ODC1,SLC7A5,HSD11B2,ASAP3,UNG,CCDC68,PSAT1,CNR1,MGAT5,DGAT2,VSIG4,TRIB3,PCK1,NDN,BCL2L1,C2orf88,SLC48A1,ATP6V1F,LPAR1,MRPL17,PAG1,PRMT5,EPHB3,NR5A2,CLDN2,SOX9,ESR2	38	
Cellular Movement	scattering	scattering	1.27E-04	 	1.600	bias	0.440	PLIN1,TP63,SPP1,CFL1,PTPN23,MMP14,RACK1,RAB7A,ADIPOQ,ANXA2,MTCH2,FGF1,ARF6,KIFC3,CDC42,CSPG4,CSF1,RET,TMSB10/TMSB4X,ETV5,CD151	21	
Cellular Function and Maintenance, Tissue Development	function	function of bone cells	1.28E-04	 	 	 	 	APOE,SPP1,SLC4A2,TYROBP,SLC1A5,MMP14,ADIPOQ,FGFR2,THRA,CEBPB,GPR55,PTPRC,CD68,CSF1,FCER1G,CLCN7,GSK3B,HCST,CHI3L1,ALPL	20	
Cell Cycle	interphase	arrest in interphase of tumor cell lines	1.33E-04	 	 	 	 	RRM2B,HRAS,MNAT1,MTCH2,GSPT1,CCND3,CSE1L,HOXA10,ITGAV,UBL5,BIRC7,YWHAG,SPP1,GPS2,ANXA2,KLF4,DUSP1,CDC42,RBX1,BTG2,NUAK1,TFRC,GNL3,MAP2K3,CYR61,ESR2,DDIT3,OSGIN1,ATF5,GDF15,ADIPOQ,RPL7A,MLH1,SYNM,HLA-G,RABL6,TCP1,NFE2L2,TP63,TAF6,HYAL1,CEBPB,DEGS1,CYP1B1,RBCK1,SOX9,PLAU,MMP9,ADRA1A	49	
Cancer	transformation	transformation of fibroblast cell lines	1.34E-04	Increased	2.481	bias	0.271	NPM1,RPS3A,PTPN23,PDGFA,CD4,HRAS,DIRAS1,EIF2S1,BIN1,ODC1,SHC1,DYNLL1,RHOG,CCND3,EFNB1,PRKCE,GNA13,RET,ADCY2,MECOM,EGR1,GNA12,CLTC,CDK6,FGFR2,TPM3,LZTS2,JUNB,HMGA1,CSF1R,NDUFA13,ATIC,FGF1,FOSB,SH3GL1,FOS,NTRK3,CDC42,CSF1,BTG2,PRMT5,MAPK10,SOX9,TMEM176B,RPL41,FTH1,ALK	47	
Cell Death and Survival	cell death	cell death of macrophages	1.34E-04	 	0.582	 	-0.015	APOE,MSR1,DDIT3,PYCARD,RAN,C1QA,HIF1A,FAS,IRAK1,HMOX1,LYZ,PRKCE,NFE2L2,PLAT,TNFRSF1A,CEBPB,APP,FOS,BCL2L1,CSF1,CTSB,NR4A1,CD14,PIK3AP1,MAP2K3,C3AR1	26	
Cancer, Organismal Injury and Abnormalities	malignant neoplasm of mediastinum	malignant neoplasm of mediastinum	1.39E-04	 	-1.614	bias	 	TP63,SRPX,PRDX1,TUBB4B,EGR1,TUBG1,TUBB2A,FKBP1A,HIF1A,CSF1R,ATIC,MLH1,PTPRC,ZBTB7B,CCND3,BMF,XRCC6,TOP2A,KIT,TUBA1C,RET,NFE2L2,POLE3	23	
Cellular Assembly and Organization	stabilization	stabilization of filaments	1.39E-04	 	1.838	 	1.668	CFL1,MBP,DVL1,MAP1B,NQO1,PKM,RAPGEF3,DYNLT1,DCLK1,CSF1R,CLIP1,APP,DCLK2,KIFC3,FLNA,ERBB4,MAPT,LOC102724428/SIK1,ARHGEF2,GSK3B,DSP,MAPRE3,PLAT	23	
Cellular Function and Maintenance	receptor-mediated endocytosis	receptor-mediated endocytosis	1.39E-04	Increased	2.951	bias	 	SORL1,APOE,ATP6V0C,SCARA5,CUBN,FAT3,LDLRAD3,ATP6AP1,HNRNPK,ARF6,MICALL1,STAB1,DAB2,PI4KB,CLTC,CLEC9A,RPS21,AP2S1,HAX1,APP,ATP6V1E1,SCARA3,ATP6V1F,CDC42,PPT1,ATP6V0D1,APOC1,CD14,LRP8,ATP6V1B2	30	
Cell Death and Survival	apoptosis	apoptosis of connective tissue cells	1.40E-04	 	0.204	 	0.190	TRAF3,SH3GLB1,HRAS,HSPA5,CTBP1,SGPL1,CTSD,NUPR1,ITGAV,GSK3B,KLF2,NSMAF,FGFR2,SHOX,BCL2L1,ADAM12,CDC42,DUSP1,XRCC6,MBD4,IGFBP3,DUSP4,GNL3,MAP2K3,SFRP1,LEP,DDIT3,PYCARD,ATF5,ADIPOQ,EIF2S1,FAS,STUB1,SAA1,TGFB2,HSD11B2,NFE2L2,TNFRSF1A,MAP3K1,EMD,GABBR1,SOD1,CEBPB,NFE2L1,APP,GRN,CIDEA,CAPNS1,CSF1,SERPINH1,USP22,NR4A1,CYCS,MMP9	54	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	response	response of phagocytes	1.40E-04	Increased	3.758	bias	1.786	GAB2,NPM1,CXCL12,BIN1,FAS,G6PC3,IRAK1,PTPRC,HMOX1,SHC1,THBS1,ANXA1,ANXA5,SAA1,PRKCE,STIM1,MAPKAPK2,CLCN3,EIF2AK1,PTX3,CALR,VCAM1,UCP2,HDAC2,TYROBP,FCGR2A,RAPGEF3,CAPG,CEBPB,CMC2,APP,ITGB2,TREM2,FCER1G,IL10RA,RARRES3,CD14,IRF8,PLAU,ADCYAP1,SIRPA	41	
Cellular Function and Maintenance, Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development	function	function of osteoclasts	1.40E-04	 	 	 	 	SPP1,SLC4A2,TYROBP,SLC1A5,MMP14,THRA,CEBPB,GPR55,PTPRC,CD68,CSF1,FCER1G,CLCN7,HCST,CHI3L1	15	
Cell Death and Survival	apoptosis	apoptosis of heart cells	1.42E-04	 	-0.402	 	0.450	SOCS3,SFRP2,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,S100A1,CALR,CALCRL,SPP1,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A	36	
Cellular Function and Maintenance	ion homeostasis	ion homeostasis of cells	1.46E-04	Increased	3.387	bias	1.349	SLC9A1,PTPRC,GNB1,ABCC1,GNA13,SLC24A3,STOML2,ANXA2,JUNB,CD52,INPP4B,BSG,RTN4,TFRC,ATOX1,ADCYAP1,C3AR1,SORL1,APOE,SLC24A2,SLC4A2,LRP6,ADIPOQ,PPIA,G6PC3,MAFG,PRKCE,STIM1,BCAP31,SLC30A1,SIGMAR1,LETM1,UCP2,FCGR2A,GNA12,SLC39A6,APP,ITGB2,FIS1,FTL,BMP6,ABCC3,ADRA1A,PLCB2,SLC31A1,ARF1,CD4,MBP,CXCL12,NME2,HSPA5,CD28,PLCE1,CAMK2D,STC2,ITGAV,CYBB,NEO1,HOXA7,ANXA7,CLCN3,KLF2,EIF2AK1,SPP1,STK39,BCL2L1,MAPT,EIF5A,AKR1B1,CYP4A11,FPR3,LEP,SCARA5,PPIB,CFTR,HIF1A,FAS,TACR1,HMOX1,KCNMA1,SAA1,ANXA1,HSD11B2,KIT,RMDN3,PRNP,CALR,EDNRB,TRPA1,SOD1,APLP2,LPAR1,SLC16A1,PAG1,FECH,NUCB2,CLDN2,ATP6V1B2	98	
Cellular Growth and Proliferation, Tissue Development	generation	generation of cells	1.46E-04	Increased	4.379	bias	-0.259	ADAMTS8,CLSTN2,SLC9A1,CLIP1,ODC1,SPRY4,PTPRC,CCND3,SRPX2,MCOLN3,KIF1A,SPTB,ATF4,STAM,GNA13,TMSB10/TMSB4X,YWHAG,LAIR1,CNR1,FGFR2,FLOT1,ANXA2,SMOC2,NDN,MYL9,PYGO2,BTG2,GPR65,CTSB,SQSTM1,ADCYAP1,DEAF1,APOE,NME1,USP18,SLC4A2,PLXNA3,GBP1,BAG6,ADIPOQ,LGALS9,PPIA,HEXA,PROX1,SDK1,SMARCA4,ARF6,ACTR3,PLIN2,DAB2,CSNK2B,NFE2L2,UCP2,TNFRSF1A,FCGR2A,HSPA2,CPEB4,GRN,MYO5A,FOS,MYOC,NTRK3,CSF1,PPT1,NR4A1,ARHGDIA,SOX9,BMPER,BMP6,SOCS3,TRAF3,NCDN,SEPT9,MBP,NNMT,CD28,HS6ST1,HSPA4,RHOG,HOXA10,MTMR2,PFKFB3,FSTL3,HDAC2,STK39,RILPL1,LAMA2,MAPK8IP2,CNP,EIF2B3,FIG4,THRA,ARSA,KLF4,SLC3A2,BCL2L1,SDCBP,ADAM12,MATN2,XRCC6,ALDH1A2,NAGLU,IRF8,TFPI,SIRPA,ETV5,CD151,PEBP1,SULF1,MSR1,FLRT1,HNRNPK,MLH1,HLA-G,SHC1,SAA1,LONP1,RAD23B,VCAM1,AGFG1,TP63,CAPZB,EDNRB,DVL1,NQO1,SOD1,HSPD1,KIF3B,FGF1,SHB,WIPF3,CAPNS1,KDM5D,TTL,MAP4K4,FHL5,NR6A1,THEMIS2,APOB,MMEL1,MAF,HRAS,ADGRL1,EXPH5,BBS1,ZBTB7B,SGPL1,DYNLL1,LGMN,PTP4A2,TXN,ZBTB16,RIMS3,JUNB,HMGA1,ROR1,NR1D1,BSG,STIP1,IL10RA,RTN4,MAP2K3,LRP8,SFRP1,TCF7,CYR61,C3AR1,PHLPP1,ALK,MSC,ADAM17,RALA,BTG3,HLA-A,LRP6,CDK16,FKBP1A,RUVBL1,DCLK1,CDH11,ENAH,MAFG,UCHL1,LIPA,UST,SNX10,PRKCE,STIM1,NPTXR,SMPD3,PLOD3,ADGRB2,PLAT,IL11RA,RPS19,DDX3Y,PTPRK,ADRM1,TYROBP,ACTB,EGR1,TIAL1,CYP1B1,ARL3,APP,ITGB2,PPP1R16B,TENM4,DOCK8,ADCY1,FCER1G,ATXN10,CYCS,PLAU,RUFY3,NCAM1,HOXB5,PLP1,PFN1,CD4,MAP1B,CXCL12,SDC4,DYNLT1,METAP2,NR2F1,PAX5,CYBB,CHST11,GSK3B,GPC1,RET,RAD51C,KLF2,SLC4A5,SPP1,FST,DNASE2,CDK6,RAB10,PHB2,IRX6,TIE1,CD3G,CDC42,IL1RN,SH2B3,MAPT,NUAK1,LFNG,UHMK1,STXBP5,PAFAH1B2,GEM,RNF165,LEP,SFRP2,EPB41L3,PDGFA,MMP14,VAPA,PKM,UGCG,CD83,HIF1A,FAS,TNFRSF12A,TACR1,SOX17,HMOX1,CCDC88A,THBS1,FLNA,ANXA1,EFNB1,DUSP10,ERBB4,F5,TGFB2,KIT,TCP1,MICALL1,NSMF,NR2F6,SHANK2,MAPKAPK2,CTDNEP1,ACTN1,PRNP,SEMA3E,CALR,AP3D1,MAP3K1,F13A1,MKNK2,CEBPB,CSF1R,PLXND1,EDF1,LPAR1,PAG1,EPHB3,NCKAP1L,CPEB1,RTN3,USP9Y,CARM1,MMP9	308	
Cancer, Organismal Injury and Abnormalities	neoplasia	Lymphoid Cancer and Tumors	1.47E-04	 	-1.560	 	-0.589	NPM1,SCFD2,KLHDC8B,WHSC1,PCLO,RRM2B,TIGIT,CLIP1,ODC1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,CSE1L,STAM,LSM3,GNA13,TMSB10/TMSB4X,MGAT1,UNG,ICT1,PPTC7,MSMO1,FGFR2,DCTD,CD52,DES,MYL9,CYP4B1,BTG2,DUSP4,ACTG1,ESR2,RPL41,SCN11A,STEAP3,EPHX1,APOE,PRDX1,CUBN,DPM2,SEC23B,EEF1B2,PPIA,CRAT,SMARCA4,COL16A1,HSP90AB1,SERPINA1,SNRPD3,AMOT,FKBP3,SIGMAR1,PLOD2,RPL4,MECOM,MT-TY,TUBB4B,FCGR2A,RNF157,STON1,LZTS2,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,FAM129A,CCT7,RPL37,BMPER,ABCC3,BMP6,CSTF3,ID4,ADRA1A,EEF1A1,SLC25A43,SESN2,ARL6IP5,RABEP1,ZNF79,ACO2,RACK1,BAG3,MRPL47,HSPA5,C3orf17,NNMT,CD28,TMEM132C,SAE1,RPS13,ABCB11,STAB1,TUBA1C,MTMR2,ADAMTS5,NSMAF,PFKFB3,PSMB5,HDAC2,RERG,UROS,TMC5,SLC12A7,FYB,TXNRD1,BCL2L1,SDCBP,TLN2,ADAM12,SLC25A39,XRCC6,ALDH1A2,IGFBP3,CAPN2,PIK3AP1,IRF8,TFPI,CCPG1,TNS1,PPAT,UBE2I,RPSA,POLE3,IGFBP4,RPLP1,SRPX,MSR1,MECR,FAT3,ALAS1,MLH1,IRAK1,HLA-G,SHC1,COL6A1,MCAM,KLHL42,DNAAF1,LONP1,ATP13A2,MT-CO1,SLC20A1,MT-ATP6,TP63,TUBG1,NQO1,ST3GAL6,TRPA1,HSPD1,ATIC,CXCL16,SCARA3,SLC33A1,PSMD2,MUC17,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,RAN,NCSTN,MKI67,RPS11,BBS1,RAD23A,CECR1,BCAT1,ZBTB7B,SGPL1,C9orf91,LGMN,PRG4,MPV17L2,PLCXD1,CTSS,GAA,ABCC1,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,CFL1,SLC24A3,TUBB2A,HMGA1,JUNB,ROR1,KIAA0100,CTPS1,SH3GL1,ACAD11,NUGGC,CCND2,CD68,DHRS9,C19orf53,CNTNAP4,ARHGAP35,CCT3,MAP2K3,LRP8,TCF7,CYR61,SETBP1,GSTP1,ALK,SORL1,MSC,SLC24A2,ADAM17,NID2,PSMB10,HLA-A,LRP6,ST6GALNAC4,FKBP1A,KAZN,MACC1,LIPA,RPL35,LYZ,MYO5C,TTC7B,MT-CYB,SCN3A,TOP2A,NPTXR,RPS12,LIMCH1,LAMB4,RPS24,MYH1,CCDC68,RPS19,SLC25A13,PTPRK,SYNGR2,IMPDH2,ACTB,EGR1,TRIM28,STXBP6,CYP1B1,STS,ITGB2,B4GALT2,MRPL51,PSME1,PDIA6,IMMT,UQCR10,BMF,USP22,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,CXCL12,TCEB2,VDAC2,PAX5,NARS,SLC29A3,SLC25A6,RPL13,DPP3,CDON,ANXA7,GSK3B,RET,COL27A1,DSP,EIF2AK1,SPP1,POLR1A,ANLN,PSMF1,CDK6,ST6GALNAC3,HIST1H2BK,ATP10A,MARS,RPL28,UBXN11,CD3G,SH2B3,CD14,GNL3,LFNG,STXBP5,CYP4A11,RPL13A,RNPEP,RBBP8,HIF1A,FAS,ERV3-1,MPEG1,THBS1,KCNMA1,ANXA1,F5,KIT,SEMA3B,HCST,ASAP3,SHANK2,ADAMTS15,CALR,COL5A2,TPST2,RARS2,MAP3K1,R3HDM1,CLEC9A,GABBR1,CEBPB,CSF1R,KIAA1683,ARHGEF10L,MT-ND5,PAG1,SLC16A1,EPHB3,UQCRC1,SEMA4B,ATP6V1B2,MMP9,SHMT2	344	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of phagocytes	1.47E-04	Increased	3.132	bias	1.169	NPM1,GAB2,BIN1,FAS,PTPRC,HMOX1,THBS1,SAA1,ANXA5,ANXA1,STIM1,CLCN3,MAPKAPK2,EIF2AK1,PTX3,CALR,UCP2,FCGR2A,RAPGEF3,CAPG,CEBPB,APP,ITGB2,TREM2,FCER1G,CD14,PLAU,SIRPA	28	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	neuroendocrine tumor	neuroendocrine tumor	1.48E-04	 	0.851	 	1.383	ASS1,HRAS,RNASE1,ODC1,POR,ZBTB7B,CCND3,CTSS,TUBA1C,GSK3B,RET,ALDOC,DKC1,TUBB2A,FGFR2,ANXA2,SDHC,GALNT13,HMGA1,TMEM127,ADRA2A,ALDH1A2,CTSB,POLE3,HTATIP2,SFRP2,LEP,PRDX1,PAM16,MMP14,HMGN1,FKBP1A,HIF1A,SMARCA4,HMOX1,HSP90AB1,PREPL,KCNMA1,THBS1,TOP2A,HSD11B2,KIT,ARHGEF2,VCAM1,TUBB4B,EGR1,TUBG1,HSPD1,CSF1R,ID4,ADRA1A,MMP9,NCAM1	53	
Cell Signaling, Molecular Transport, Small Molecule Biochemistry, Vitamin and Mineral Metabolism	release	release of Ca2+	1.48E-04	Increased	2.541	bias	0.729	S100A11,FPR3,RAB32,LEP,DDIT3,AHCYL1,CD4,RACK1,CXCL12,FKBP1A,TMBIM6,FAS,GPR55,PTPRC,CD28,ANXA1,PACS2,ITGAV,CYBB,PRKCE,STIM1,HCST,BCAP31,PRNP,S100A1,CALR,SPP1,LMO4,FCGR2A,DVL1,SOD1,CSF1R,NDN,APP,MYO5A,BCL2L1,CSF1,FCER1G,P2RY12	39	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis of hippocampus	1.48E-04	 	0.555	 	1.060	APOE,MAPT,PPT1,ADIPOQ,CLCN7,APP	6	
Cell Death and Survival	cell death	cell death of heart	1.48E-04	 	-0.076	 	0.904	SCD,SOCS3,SFRP2,LEP,HSPB8,ADIPOQ,CTSG,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,PLAT,HK1,S100A1,CALR,CALCRL,SPP1,PPIF,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,SGCD,ADRA1A,RPSA	42	
Post-Translational Modification, Protein Degradation, Protein Synthesis	hydrolysis	hydrolysis of protein fragment	1.48E-04	 	0.293	 	0.467	SPCS1,CSTA,ADAM17,TRAF3,CMA1,BAG6,MMP14,CTSG,NCSTN,OGT,CTSD,CNDP2,LGMN,F8,DPP3,CTSS,FBXW11,TRABD2A,F5,CHMP1A,LONP1,CLN6,PLAT,PSMB5,HDAC2,PSMC4,AURKAIP1,NR1H3,CPA3,DNAJC1,CSTB,SERPINE2,HSPA8,CTSA,CAPNS1,CTSB,TPP1,CAPN2,SFRP1,ADAM9,MMP9,RNPEP	42	
Carbohydrate Metabolism	accumulation	accumulation of polysaccharide	1.50E-04	 	0.233	 	-0.280	OSTM1,APOE,SREBF1,GLB1,PPP1R3C,GAA,HYAL1,CYBB,HEXA,SOD1,TAF10,B3GAT3,BMP6,IL11RA	14	
Cell Signaling	Rho protein signal transduction	Rho protein signal transduction	1.50E-04	 	-0.841	 	-0.670	CFL1,GNA12,FLOT1,TAX1BP3,GPR55,KCTD13,MYOC,RHOG,ADRA2A,LPAR1,SRGAP1,RHOD,ARHGAP35,ARHGDIA,ARHGEF2,CDC42EP1,GNA13,HACD3,ADRA1A	19	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	export	export of lipid	1.52E-04	Increased	2.479	bias	1.267	APOE,SCD,LEP,APOB,MSR1,SNTB1,GDF15,ADIPOQ,NR1H3,CRAT,HRAS,SLC25A1,IRAK1,APP,CES1,CTSS,CDC42,SREBF1,ABCC1,SAA1,SLC16A1,APOC1,ABCB11,CD14,PLTP,ABCC3	26	
Skeletal and Muscular System Development and Function	contractility	contractility of muscle	1.56E-04	 	0.464	bias	-1.890	SULF1,GAB2,APOE,LEP,PFKFB1,HSPB8,ADIPOQ,FKBP1A,MRVI1,HMOX1,SHC1,AK1,COL6A1,PLCE1,KCNMA1,EFNB1,PLIN5,PLAT,MYH1,S100A1,SPP1,TRIM55,SLC6A6,MAP3K1,NR1H3,SOD1,JUNB,DES,COX7A1,ENO1,LAMP2,CDC42,PLAU,SGCD,ESR2,MMP9	36	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	response	response of macrophages	1.58E-04	Increased	3.528	bias	1.852	GAB2,NPM1,BIN1,G6PC3,FAS,IRAK1,PTPRC,HMOX1,THBS1,ANXA1,SAA1,PRKCE,MAPKAPK2,EIF2AK1,PTX3,CALR,UCP2,HDAC2,FCGR2A,RAPGEF3,CAPG,CEBPB,CMC2,APP,ITGB2,TREM2,FCER1G,IL10RA,CD14,IRF8,SIRPA	31	
Nervous System Development and Function	morphology	morphology of nervous system	1.59E-04	 	 	 	 	NR6A1,SLC29A4,APOB,RRM2B,C1QA,PTPRC,ABR,GLB1,WNT5B,SV2B,CNR1,TPM3,NR1H3,FGFR2,CLN5,NDN,SH3GL1,CCND2,PRKACA,RTN4,CTSB,ARHGAP35,LRP8,ESR2,SORL1,APOE,BAG6,HEXA,SDC3,DCLK1,CDH11,CETN2,LIPA,SMPD3,NFE2L2,NDUFS4,MECOM,TYROBP,TNFRSF1A,EGR1,CSTB,CPEB4,APP,GRN,B4GALT2,MARCKSL1,NTRK3,PPT1,ADCY1,PEA15,TPP1,PSAP,SIM1,NCAM1,NAB2,HOXB5,PLP1,PFN1,MBP,MAP1B,CXCL12,TYMP,NR2F1,CTSD,CDON,LYNX1,HOXA10,MTMR2,GCLM,GSK3B,RET,CLCN3,SPP1,FST,ACP2,HDAC2,LMO4,PTPRQ,GM2A,LAMA2,MAPK8IP2,IRX6,SLC12A7,THRA,ARSA,BCL2L1,DNAJC5,CDC42,DUSP1,IL1RN,MAPT,XRCC6,MAPK10,NAGLU,MEGF8,TMEM176B,SULF1,LEP,EPB41L3,FAT3,HIF1A,CCDC88A,PARK7,STUB1,CSPG4,ERBB4,EFNB1,TGFB2,EGLN3,SHANK2,CACNG8,ALPL,GMFB,ATP13A2,PRNP,CAPZB,NPY1R,DVL1,GABBR1,SOD1,NFASC,SLC5A3,KIF3B,FGF1,SERPINE2,PLCB4,APLP2,LPAR1,SLC33A1,TTL,EPHB3,ADAM9	132	
Cellular Development, Cellular Growth and Proliferation, Renal and Urological System Development and Function	cell proliferation	cell proliferation of kidney cell lines	1.59E-04	 	0.508	 	-0.072	SOCS3,RALA,MMP14,DUSP6,UNC5B,TTLL4,HRAS,CES2,MMP25,HSPA4,PLCE1,HSP90AB1,ERBB4,RET,SLC30A1,AMOT,STT3B,PFKFB3,PTP4A3,FGFR2,HSPD1,CDK2AP1,CSF1R,FGF1,GRN,FOS,PPP2R1A,SDCBP,MYOC,CSF1,ADCY1,RARRES3,VDAC1,PPP2R1B	34	

Tox Functions for My Projects->David Bulger->P3
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Renal Necrosis/Cell Death	cell death	cell death of kidney cells	1.00E-05	 	0.872	 	-0.325	GFPT1,CTGF,CCNI,UNC5B,HRAS,HSPA5,SGPL1,RHOG,CDON,MCOLN3,ABCC1,ITGAV,NEO1,GSK3B,GNA13,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,DUSP1,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,SFRP1,VDAC1,GSTP1,APOE,GSTM5,DDIT3,PYCARD,LRP6,HYOU1,HIF1A,FAS,STUB1,ERBB4,AAK1,NFE2L2,GMFB,ATP13A2,PRNP,TMEM123,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,FGF1,APP,EMP1,FOS,MYOC,TNFAIP8L2,GLIS2,NTRK3,SREBF2,CSF1,PEA15,CYCS,SLC47A1	66	
Renal Necrosis/Cell Death	cell death	cell death of kidney cell lines	2.73E-05	 	1.145	 	-0.219	UNC5B,HRAS,HSPA5,SGPL1,RHOG,CDON,MCOLN3,ABCC1,ITGAV,NEO1,GSK3B,GNA13,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,VDAC1,GSTP1,GSTM5,DDIT3,PYCARD,LRP6,HYOU1,FAS,STUB1,ERBB4,AAK1,NFE2L2,GMFB,ATP13A2,TMEM123,PRNP,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,APP,FGF1,EMP1,FOS,MYOC,TNFAIP8L2,NTRK3,SREBF2,PEA15,CYCS,SLC47A1	57	
Cardiac Infarction	myocardial infarction	myocardial infarction	3.73E-05	 	-0.393	 	0.242	APOE,DUSP6,GDF15,ADIPOQ,CXCL12,HIF1A,NPC1L1,NNMT,HMOX1,CYBB,ITGAV,PRKCE,TUBA1C,GCLM,GSK3B,MAPKAPK2,PLAT,PTX3,PPIF,TNFRSF1A,TUBB4B,FCGR2A,TUBG1,TUBB2A,F13A1,THRA,SOD1,CSF1R,APP,ITGB2,ADRA2A,VKORC1,IL1RN,CSF1,SH2B3,FCER1G,CCT7,P2RY12,CD14,LRP8,C6,TFPI,MMP9,ADRA1A	44	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart	7.86E-05	 	-0.022	 	0.840	SOCS3,SCD,SFRP2,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,S100A1,CALR,CALCRL,SPP1,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A	37	
Liver Necrosis/Cell Death	cell death	cell death of liver	1.05E-04	Decreased	-2.171	 	-1.171	SCD,APOE,SOCS3,DDIT3,ADIPOQ,HRAS,UGCG,FKBP1A,TMBIM6,TAF10,FAS,PTPRC,TACR1,SLC19A3,HMOX1,SHC1,ARF6,FLNA,ENTPD5,SAA1,ITGAV,GSK3B,NFE2L2,SLC20A1,TYROBP,TNFRSF1A,SOD1,HSPD1,CEBPB,NFE2L1,APP,RBCK1,FOS,ITGB2,BCL2L1,LAMP2,IL1RN,SERPINH1,BMF,CTSB,CD14,DUSP4,IRF8,SLC25A5,MMP9	45	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart cells	1.42E-04	 	-0.402	 	0.450	SOCS3,SFRP2,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,S100A1,CALR,CALCRL,SPP1,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A	36	
Cardiac Necrosis/Cell Death	cell death	cell death of heart	1.48E-04	 	-0.076	 	0.904	SCD,SOCS3,SFRP2,LEP,HSPB8,ADIPOQ,CTSG,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,PLAT,HK1,S100A1,CALR,CALCRL,SPP1,PPIF,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,SGCD,ADRA1A,RPSA	42	
Renal Proliferation	cell proliferation	cell proliferation of kidney cell lines	1.59E-04	 	0.508	 	-0.072	SOCS3,RALA,MMP14,DUSP6,UNC5B,TTLL4,HRAS,CES2,MMP25,HSPA4,PLCE1,HSP90AB1,ERBB4,RET,SLC30A1,AMOT,STT3B,PFKFB3,PTP4A3,FGFR2,HSPD1,CDK2AP1,CSF1R,FGF1,GRN,FOS,PPP2R1A,SDCBP,MYOC,CSF1,ADCY1,RARRES3,VDAC1,PPP2R1B	34	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of cardiomyocytes	1.74E-04	 	-0.261	 	0.557	SOCS3,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,S100A1,CALR,CALCRL,SPP1,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A	35	
Cardiac Necrosis/Cell Death	necrosis	necrosis of cardiac muscle	2.04E-04	 	-0.305	 	0.603	SOCS3,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,PLAT,HK1,S100A1,CALR,CALCRL,SPP1,PPIF,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,SGCD,ADRA1A,RPSA	40	
Liver Necrosis/Cell Death	necrosis	necrosis of liver	3.46E-04	Decreased	-2.013	 	-1.038	SCD,SOCS3,APOE,DDIT3,ADIPOQ,HRAS,UGCG,FKBP1A,TMBIM6,FAS,PTPRC,TACR1,SLC19A3,HMOX1,SHC1,ARF6,FLNA,ENTPD5,SAA1,ITGAV,GSK3B,NFE2L2,SLC20A1,TYROBP,TNFRSF1A,SOD1,HSPD1,CEBPB,NFE2L1,RBCK1,FOS,ITGB2,BCL2L1,LAMP2,IL1RN,SERPINH1,BMF,CTSB,CD14,DUSP4,IRF8,SLC25A5,MMP9	43	
Cardiac Necrosis/Cell Death	cell death	cell death of heart cells	5.21E-04	 	-0.447	 	0.441	SOCS3,SFRP2,LEP,HSPB8,ADIPOQ,CTSG,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,HK1,S100A1,CALR,CALCRL,SPP1,PPIF,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A,RPSA	39	
Cardiac Necrosis/Cell Death	cell death	cell death of cardiomyocytes	5.43E-04	 	-0.311	 	0.519	SOCS3,LEP,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,HK1,S100A1,CALR,CALCRL,SPP1,PPIF,HDAC2,FSTL3,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,ADRA1A,RPSA	38	
Renal Damage	nephrotoxicity	nephrotoxicity	7.50E-04	 	 	 	 	SLC7A11,SPP1,NQO1,ST6GALNAC3,JUNB,GSS,TXNRD1,SLC38A3,ODC1,LYZ,SLC25A11,CTSS,BTG2,IGFBP3,PSMA3,TMSB10/TMSB4X,CRYM,GJB2,GSTP1	19	
Liver Necrosis/Cell Death	cell death	cell death of liver cells	9.90E-04	 	-1.256	 	-0.990	SOCS3,APOE,SCD,DDIT3,ADIPOQ,HRAS,UGCG,TMBIM6,FAS,TACR1,PTPRC,HMOX1,SHC1,ARF6,ENTPD5,SAA1,ITGAV,GSK3B,NFE2L2,SLC20A1,TNFRSF1A,HSPD1,CEBPB,RBCK1,FOS,BCL2L1,ITGB2,LAMP2,IL1RN,SERPINH1,BMF,CTSB,DUSP4,SLC25A5,MMP9	35	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cell lines	1.14E-03	Increased	2.180	 	1.088	DDIT3,PYCARD,LRP6,UNC5B,HYOU1,HRAS,HSPA5,FAS,SGPL1,RHOG,STUB1,CDON,ABCC1,MCOLN3,ITGAV,GSK3B,GNA13,DPM3,NFE2L2,GMFB,SPP1,TNFRSF1A,GNA12,GNG2,MAP3K1,TRIB3,SDHC,HAX1,FGF1,APP,FOS,BCL2L1,MYOC,SREBF2,MAPT,PEA15,IGFBP3,TFRC,CYCS,DUSP4,VDAC1	41	
Liver Proliferation	proliferation	proliferation of liver cells	1.17E-03	Increased	2.987	 	1.972	SOCS3,LEP,CTGF,MMP14,ADIPOQ,CXCL12,HRAS,PROX1,GPC3,ODC1,FAS,TNFRSF12A,CCND3,THBS1,ENTPD5,CXCL14,ITGAV,SLC7A5,GSK3B,NFE2L2,SLC20A1,FST,SPP1,EDNRB,TNFRSF1A,CNR1,FGFR2,CEBPB,FOS,IL1RN,SERPINH1,CTSB,C3AR1	33	
Renal Damage, Renal Tubule Injury	proximal tubular toxicity	proximal tubular toxicity	1.18E-03	 	 	 	 	SPP1,NQO1,ST6GALNAC3,JUNB,GSS,TXNRD1,SLC38A3,ODC1,LYZ,SLC25A11,CTSS,BTG2,IGFBP3,PSMA3,TMSB10/TMSB4X,CRYM,GJB2,GSTP1	18	
Liver Damage	damage	damage of liver	1.26E-03	 	0.244	 	0.224	SCD,APOE,LEP,DDIT3,PYCARD,HLA-A,KLRD1,ADIPOQ,LGALS9,FKBP1A,SDC4,FAS,CERS2,PTPRC,POR,HMOX1,STUB1,GAA,KEAP1,SAA1,ABCB11,STAB1,SERPINA1,NFE2L2,IL11RA,SPP1,TNFRSF1A,IMPDH2,EGR1,GABBR1,SOD1,SAA2,ITGB2,BCL2L1,BSG,IL1RN,CSF1,DUSP1,CTSB,CD14,MAP2K3,PLAU,C3AR1,MMP9,GSTP1	45	
Liver Damage	injury	injury of liver	1.66E-03	 	-0.615	 	-0.485	SCD,APOE,LEP,DDIT3,HLA-A,KLRD1,ADIPOQ,LGALS9,FKBP1A,SDC4,FAS,PTPRC,POR,HMOX1,STUB1,GAA,SAA1,ABCB11,STAB1,SERPINA1,NFE2L2,IL11RA,SPP1,TNFRSF1A,IMPDH2,EGR1,GABBR1,SOD1,SAA2,BCL2L1,ITGB2,BSG,CSF1,IL1RN,CTSB,CD14,MAP2K3,MMP9	38	
Liver Inflammation/Hepatitis	inflammation	inflammation of liver	1.92E-03	Decreased	-2.052	bias	-0.199	SCD,APOE,TRAF3,APOB,LEP,F2RL3,DDIT3,SCARA5,HLA-A,LRP6,ADIPOQ,LGALS9,PPIA,FKBP1A,FAS,PTPRC,POR,SLC19A3,HMOX1,STUB1,GAA,ENTPD5,PHYH,ABCB11,STAB1,NFE2L2,SPP1,TYROBP,TNFRSF1A,FCGR2A,IMPDH2,EGR1,GABBR1,SOD1,NFE2L1,EFS,ITGB2,BCL2L1,TNFAIP8L2,IL1RN,CSF1,NAGLU,CD14,PLAU,CYR61,TFPI,GSTP1,MMP9	48	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	hepatocellular carcinoma	2.32E-03	 	-0.489	 	-0.047	MVD,SOCS3,EEF1A1,PLCB2,APOB,WHSC1,PFN1,ARF1,ARPC5,LDB3,RACK1,HRAS,TYMP,GHITM,HSPA5,GPC3,BIN1,GPR55,POR,NNMT,CTSD,DYNLL1,DPP3,MEGF6,CSE1L,ENTPD5,KEAP1,NUPR1,ABCB11,STAB1,ANXA7,TXN,RET,SPP1,YWHAG,ANLN,HNRNPAB,FGFR2,THRA,TXNRD1,LMCD1,SPATA20,BCL2L1,ADAM12,BSG,TMEM176A,IGFBP3,RTN4,TMX2,ACTG1,ARL2,ERAP2,SCD,ADAM17,HTATIP2,NME1,RALA,LEP,SLC1A4,CHCHD10,PRDX1,MMP14,PKM,FKBP1A,PROX1,HIF1A,NLK,ANXA1,F5,TOP2A,SAMD1,SENP3,KIT,OGDH,NFE2L2,ATP13A2,AKR1C1/AKR1C2,EDNRB,TUBB4B,NQO1,SLC39A6,GABBR1,IPO7,SOD1,PSME3,CSF1R,COPG1,FTL,PLCB4,TNFAIP8L2,LPAR1,CSF1,SOX9,CBX4,CLDN2,PLAU,ADAM9,MMP9	98	
Liver Steatosis	hepatic steatosis	hepatic steatosis	2.78E-03	 	-1.204	 	0.216	SCD,APOE,APOB,LEP,DDIT3,LRP6,BAG3,ADIPOQ,LGALS9,NPC1L1,PNRC2,SLC27A4,POR,LIPA,HMOX1,CSPG4,PLIN2,PHYH,EGLN3,ABCB11,ATF4,SERPINA1,KLF2,SLC25A13,UCP2,SPP1,FSTL3,GPS2,TNFRSF1A,CNR1,FGFR2,NR1H3,THRA,SOD1,PCK1,PSME3,NFE2L1,SREBF1,DUSP1,NR4A1,CD14,ADCYAP1,CYP4A11,SIRPA,GSTP1	45	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells	3.69E-03	 	1.258	bias	0.453	CTGF,LEP,SPP1,EDNRB,SERPINH1,CNR1,MMP14,CTSB,CXCL12,ADIPOQ,ITGAV	11	
Liver Cirrhosis	primary biliary cirrhosis	primary biliary cirrhosis	4.23E-03	 	 	 	 	APOB,SPP1,SLC4A2,FST,CTGF,NQO1,NR1H3,HNRNPK,FGF1,BSG,SREBF2,ABCC1,TGFB2,NR4A1,ABCB11,ABCC3,ALPL	17	
Liver Cirrhosis	cirrhosis	Cirrhosis	4.68E-03	 	 	 	 	ADAM17,LEP,APOB,SLC4A2,CTGF,UTP4,HNRNPK,ABCC1,F5,TOP2A,TGFB2,ABCB11,SERPINA1,GCLM,ALPL,NFE2L2,SPP1,FST,EDNRB,TNFRSF1A,EGR1,NQO1,NR1H3,FGF1,VKORC1,BSG,SREBF2,CSF1,NR4A1,ABCC3,MMP9,GSTP1,ADRA1A	33	
Cardiac Proliferation	proliferation	proliferation of heart cells	4.72E-03	 	0.304	 	-0.098	CALCRL,ADAM17,LEP,RAB1A,HDAC2,KCNK2,ADIPOQ,SMARCA4,FGF1,ITGB2,HMOX1,PLCE1,DUSP1,ALDH1A2,KIT,HSD11B2,GNL3,GSK3B	18	
Liver Cholestasis	secretion	secretion of bile acid	5.33E-03	 	0.832	 	0.567	HMOX1,CES1,CYP27A1,ABCB11	4	
Liver Damage	drug-induced hepatotoxicity	drug-induced hepatotoxicity	6.01E-03	 	 	 	 	SLC7A11,GSS,FAS	3	
Increased Levels of LDH	release	increased release of LDH	7.58E-03	 	 	 	 	HMOX1,ITGB2,SLC9A1,KLF4,APP	5	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart	7.59E-03	 	1.139	 	1.511	PFN1,CTGF,PFKFB1,CXCL12,HRAS,SLC9A1,CTSD,PLCE1,CAMK2D,GAA,PNKD,CYBB,PLIN5,GSK3B,TXN,HDAC2,FSTL3,RAPGEF3,HMGA1,KLF4,DES,LMCD1,MYL9,MTPN,ADRA2A,DUSP1,CTSB,MAP2K3,ESR2,APOE,ADAM17,RAB4A,RAB1A,LEP,PDGFA,GDF15,ADIPOQ,HSPB8,PPIA,FKBP1A,HIF1A,H2AFZ,SHC1,HMOX1,PARK7,PRKCE,PLAT,TRIM55,PRMT5,PLAU,MMP9,ADRA1A	52	
Liver Adhesion	adhesion	adhesion of hepatic stellate cells	7.81E-03	 	 	 	 	CTGF,ADAM12	2	
Renal Damage	drug toxicity-related nephropathy	drug toxicity-related nephropathy	7.81E-03	 	 	 	 	SLC7A11,GSS	2	
Liver Inflammation/Hepatitis, Liver Necrosis/Cell Death	necrotizing inflammation	necrotizing inflammation of liver	7.81E-03	 	 	 	 	APOE,TNFRSF1A	2	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatic stellate cells	8.03E-03	 	-0.651	 	-0.953	SERPINH1,ADIPOQ,ITGAV,CEBPB,FAS,MMP9	6	
Liver Hyperplasia/Hyperproliferation	liver tumor	liver tumor	8.12E-03	 	0.171	 	0.636	NPM1,PCLO,RPE,ASS1,GARS,LRRN4CL,SPRY4,GPR55,POR,CCND3,ATG9A,GLB1,CSE1L,GORASP2,VIT,GNA13,SLC2A5,YWHAG,ANXA2,ALCAM,ELMO2,ADCYAP1,ACTG1,EPHX1,EVA1B,HTATIP2,FHL1,DDIT3,SLC1A5,PRDX1,BAG6,SMARCA4,ALPK2,AMOT,MTSS1L,UCP2,MECOM,TUBB4B,RNF157,IPO7,RNF6,MYO5A,MTHFD1L,AFF3,EDIL3,CSF1,DERL1,NR4A1,RPL37,SOX9,EEF1A1,SOCS3,PCDH18,EML4,SCN7A,SLC9A9,AP1B1,DNAJC15,GPC3,LHFPL2,CTSD,TSEN15,STRN4,STC2,ABCB11,MTMR2,ADAMTS5,NSMAF,C12orf49,STXBP1,SESN3,HDAC2,CBX6,ASNA1,MAPK8IP2,FIG4,FYB,TXNRD1,BCL2L1,ADRA2A,NAGLU,TMX2,CBX3,TNS1,ETV5,SULF1,SCD,ZC3H7B,CARS,F2RL3,FAT3,NHP2,PKHD1L1,RPL7A,FILIP1,COL6A1,F8,C16orf59,IGSF8,AKR1C1/AKR1C2,TRIM55,IPO4,TRIM2,SOD1,SAA2,TSN,CFAP97,UTY,WIPF3,POLR3B,TBL1Y,C7orf43,MAP4K4,CPAMD8,ITGA8,ARPC5,RAN,CA12,GHITM,MKI67,EXPH5,ABCC6,SGPL1,C9orf91,LRFN5,LGMN,DUSP3,PRG4,ZNF605,FAM124B,PXK,POU6F2,KIF21A,MED16,ZBTB16,SV2B,PTP4A3,DKC1,CPNE4,ROR1,BCAP29,TSR3,FARSA,INPP4B,NCLN,RTN4,ME2,ARHGAP35,GSTP1,SORL1,NQO2,PPP1R3C,LRP6,HYOU1,ST6GALNAC4,FKBP1A,GPC4,EAF1,CDH11,ENAH,CADM2,CES1,MYO5C,TTC7B,DIP2B,TUB,TXNL1,SMPD3,SLC30A1,LIMCH1,LAMB4,RPS24,PLXNA1,NAP1L4,NOL6,PTPRK,TRIM28,PAICS,TIAL1,LRRC8D,SNTG2,SLC48A1,BRINP2,RHBDD2,SREBF1,TREM2,AOX1,NCAM1,PLCB2,PFN1,GTF3C6,ARF1,PRMT3,MYH15,UNC5B,MAP1B,FAM127B,CHTOP,CNDP2,CAMK2D,PLCE1,DPP3,PABPC4,COMT,PCYT2,ANXA7,GOT1,GSK3B,RET,COL27A1,PCNXL2,C7orf50,MFSD3,HK1,FERMT3,THUMPD3,TRIOBP,CLTC,DGKE,FAM45A,SLC4A7,RPL12,ATP10A,GALNT13,GPAA1,TMEM176A,MAPT,RARRES3,NUAK1,TBC1D16,CYP4A11,ARL2,SPIRE1,SRM,FPR3,SH3RF3,RAB1A,ATF5,PCDHAC2,PCDH19,ILF2,MRPS30,THBS1,ERBB4,CYGB,ASAP3,OGDH,ATP5I,COL5A2,TMEM104,HSPH1,MAP3K1,R3HDM1,VSIG4,CEBPB,MRPS16,SYNPO2,PLXND1,ANO2,RPS4Y1,TMEM2,PLCB4,PAG1,ASAP2,GBE1,NUCB2,NCKAP1L,ADAM9,SEMA4B,GRPEL1,PPP2R1B,HLTF,MPV17,KLHDC8B,WHSC1,LRRC59,PCDHAC1,CLSTN2,SLC35C1,ODC1,CLIP1,NPL,PTPRC,SRPX2,EIF4G2,KEAP1,KIF1A,SPTB,ST6GALNAC2,STAM,MGAT1,MRPL24,PLD3,PPP1R1B,CNR1,TMEM201,FGFR2,NPY5R,SMOC2,DES,SPATA20,HSPA8,TMEM127,CTSA,SCUBE1,MRNIP,DUSP4,CHD1L,SQSTM1,TMEM33,ESR2,TRAPPC5,FKBP2,APOE,NME1,SFXN4,FBXO10,CHCHD10,OSGIN1,CUBN,HS2ST1,HSPB8,PROX1,MMP25,SDK1,COL16A1,OGT,ACTR3,SORBS1,TNXB,ARFGAP1,OSBPL11,ALG8,SERPINA1,CSNK2B,NFE2L2,RPN1,S100A1,TMC2,SRA1,GNA12,SLC6A6,DGAT2,SLC39A6,LZTS2,XIST,CPEB4,TBC1D13,FOS,MYOC,NTRK3,FLNC,EIF4A1,DOPEY2,MBD3,PSAP,ARHGDIA,TTYH3,ABCC3,BMP6,C11orf68,PPIL1,ID4,PTER,MEGF9,MBP,ACO2,RACK1,TYMP,CES2,MRVI1,HSPA5,C3orf17,BIN1,NNMT,TMEM132C,RHOG,MEGF6,GDE1,ENTPD5,PACS2,FAR2,NUPR1,HOXA7,STAB1,BCAS2,FSTL3,LAMA2,KCNK2,TMC5,HNRNPAB,RAPGEF3,CAPG,THRA,DMXL2,KCNG1,TLN2,ADAM12,ALG3,CDH20,XRCC6,IGFBP3,PIK3AP1,MEGF8,PTGFR,UBXN1,ERAP2,RAB4A,SLC1A4,SRPX,MSR1,SCARA5,MECR,LBHD1,HNRNPK,VPS4A,REXO2,MLH1,IRAK1,SHC1,TWF2,PREPL,DNAJC4,FAM166A,IARS,LONP1,ATP13A2,FAM171B,VCAM1,AGFG1,EDNRB,ZNF358,NQO1,HPS1,MGAT5,TRPA1,HSPD1,PSME3,AIFM2,NFE2L1,ATIC,SHB,KDM5D,KIF5B,PSMD2,SLC36A1,NOP16,MUC17,TBC1D7,EMC3,IVD,CADM3,SLC29A4,PMVK,APOB,LDB3,SH3BGRL3,HRAS,PCDH7,SH3GLB1,KPNA1,CHST2,BCAT1,DYNLL1,DGCR6L,PEG10,ABCC1,RPS2,TXN,CALCRL,TMEM9B,AASS,TSPAN33,KIAA0100,CTPS1,NR1D1,BSG,YARS,GLUL,MAP2K3,LRP8,SFRP1,TCF7,CYR61,C3AR1,ALDH4A1,MSC,ADAM17,RALA,TMEM129,NID2,UBQLN1,CTNNA1,PFKL,TTC1,DCLK1,UCHL1,DCLK2,MACC1,LIPA,C1QTNF3,TOP2A,SAMD1,PSMD14,SARS,AMFR,PLOD3,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,ACTB,ATXN2L,WDR12,CYP1B1,COPG1,AREL1,FTL,DOCK8,PPP1R16B,ADCY1,ARAP1,P2RY12,CBX4,PLAU,RUFY3,ACTR1A,EFR3A,MVD,CXCL12,MMRN1,SDC4,DYNLT1,SLC7A5,RAD51C,CLCN3,MRPL43,EIF2AK1,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,RAB10,UQCR11,MARS,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,PLEKHH2,GNL3,STXBP5,RNPEP,LEP,EPB41L3,MMP14,PKM,SLC7A1,CFTR,FAM47E,HIF1A,STXBP4,GANAB,SEPHS2,HMOX1,NLK,PCK2,FLNA,KCNMA1,ANXA1,EFNB1,F5,TGFB2,SENP3,KIT,HSD11B2,ARHGEF2,NR2F6,BHMT2,ALPL,STK40,HMGCS1,ACTN1,PRNP,SEMA3E,FRMD1,ADCY2,C10orf71,CENPV,CYP27A1,RARS2,AP3D1,COPS7A,NXPH4,GABBR1,ZBTB7C,CSF1R,SLC5A3,WARS,TNFAIP8L2,DIP2C,LPAR1,OLFML2B,PANK3,CLDN2,MAT2A,USP9Y,RTN3,CARM1,MMP9	617	
Cardiac Damage	rupture	rupture of heart	8.27E-03	 	0.000	bias	0.758	GDF15,CTNNA1,PLAU,MMP9	4	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver	8.69E-03	Decreased	-2.325	 	-1.878	SOCS3,SCD,ADIPOQ,HRAS,TAF10,TMBIM6,FAS,TACR1,PTPRC,SHC1,ARF6,SAA1,ENTPD5,ITGAV,GSK3B,SLC20A1,TNFRSF1A,CEBPB,NFE2L1,APP,RBCK1,BCL2L1,SERPINH1,BMF,CTSB,MMP9	26	
Liver Cholestasis	intrahepatic cholestasis	intrahepatic cholestasis	9.81E-03	 	 	 	 	SCD,SLC25A13,CYP27A1,AKR1C3,CFTR,SLC27A4,LIPA,SLC25A6,CD68,SREBF1,ABCB11,UQCRFS1,GJB2	13	
Renal Degeneration	degeneration	degeneration of kidney	1.02E-02	 	-0.816	bias	0.019	GLIS2,SREBF1,ARHGDIA,SDC4,TNS1,CD151	6	
Liver Failure	failure	failure of liver	1.03E-02	 	-0.832	bias	 	HMOX1,ADAM17,SLC7A11,ADRA2A,DUSP1,TOP2A,ABCB11,MARS,GSS,FAS,ADRA1A	11	
Cardiac Arteriopathy	coronary artery disease	coronary artery disease	1.08E-02	 	-1.969	bias	-1.393	APOE,APOB,SLC7A11,LRP6,ITGA8,ADIPOQ,FKBP1A,NPC1L1,SLC9A1,GSS,NNMT,SORBS1,THBS1,GAA,ITGAV,TUBA1C,OGDH,KLF2,COL5A2,MECOM,SGCG,TUBB4B,TKT,CNR1,TUBG1,TUBB2A,ALOX5AP,SOD1,RASL12,FOS,ITGB2,MTHFD1L,SUPV3L1,LAMP2,ADRA2A,VKORC1,MATN2,GBE1,CD14,P2RY12,LRP8,SGCD,ESR2	43	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiomyocytes	1.09E-02	 	0.722	 	0.310	CTGF,LEP,RAB1A,FSTL3,HDAC2,GDF15,HSPB8,ADIPOQ,PPIA,RAPGEF3,SLC9A1,H2AFZ,LMCD1,SHC1,CAMK2D,PLCE1,DUSP1,PRMT5,MAP2K3,GSK3B,PLAU,MMP9	22	
Liver Cholestasis	obstructive cholestasis	obstructive cholestasis	1.12E-02	 	 	 	 	CD68,ABCC3,GJB2	3	
Cardiac Arteriopathy	vasospasm	vasospasm of coronary artery	1.12E-02	 	 	 	 	SGCG,SOD1,SGCD	3	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction of heart	1.21E-02	 	 	 	 	SCD,LEP,CYBB,HRAS	4	
Glomerular Injury	glomerular crescent	glomerular crescent	1.28E-02	 	-1.353	bias	-0.365	RPS19,HMOX1,C1QA,PLAU,PLAT,CD151	6	
Liver Cholestasis	progressive familial intrahepatic cholestasis type 1	progressive familial intrahepatic cholestasis type 1	1.33E-02	 	 	 	 	SCD,LIPA,SLC25A13,SLC25A6,CYP27A1,AKR1C3,SREBF1,ABCB11,UQCRFS1,CFTR,SLC27A4	11	
Cardiac Dysfunction	systolic dysfunction	systolic dysfunction	1.38E-02	 	1.633	 	1.633	SCD,MARCKSL1,LEP,FSTL3,ANXA5,CYBB,FKBP1A	7	
Liver Cholestasis	cholestasis	cholestasis	1.56E-02	 	 	 	 	SCD,SLC25A13,CYP27A1,AKR1C3,CFTR,SLC27A4,FAS,LIPA,SLC25A6,CD68,SREBF1,ABCC1,UQCRFS1,ABCB11,ABCC3,GJB2	16	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular myocytes	1.58E-02	 	-1.519	 	-1.821	PLCE1,LEP,FSTL3,PRMT5,RAPGEF3,GSK3B	6	
Cardiac Pulmonary Embolism	pulmonary embolism	pulmonary embolism	1.58E-02	 	 	 	 	F2RL3,VKORC1,F5,P2RY12,TFPI,PLAT	6	
Cardiac Hypertrophy	ventricular hypertrophy	ventricular hypertrophy	1.64E-02	 	-1.378	 	-0.470	APOE,LEP,FSTL3,PDGFA,CXCL12,FKBP1A,RAPGEF3,HMGA1,HIF1A,MYL9,PLCE1,ADRA2A,GAA,PLIN5,PRMT5,GSK3B,PLAU,ESR2,ADRA1A,PLAT	20	
Liver Hyperplasia/Hyperproliferation	cancer	liver cancer	1.67E-02	 	0.037	 	0.417	NPM1,PCLO,RPE,ASS1,GARS,LRRN4CL,SPRY4,GPR55,POR,CCND3,ATG9A,GLB1,CSE1L,GORASP2,VIT,GNA13,SLC2A5,YWHAG,ANXA2,ALCAM,ELMO2,ADCYAP1,ACTG1,EPHX1,EVA1B,HTATIP2,FHL1,DDIT3,SLC1A5,PRDX1,BAG6,SMARCA4,ALPK2,AMOT,MTSS1L,UCP2,MECOM,TUBB4B,RNF157,IPO7,RNF6,MYO5A,MTHFD1L,AFF3,EDIL3,CSF1,DERL1,NR4A1,RPL37,SOX9,EEF1A1,SOCS3,PCDH18,EML4,SCN7A,SLC9A9,AP1B1,DNAJC15,GPC3,LHFPL2,CTSD,TSEN15,STRN4,STC2,ABCB11,MTMR2,ADAMTS5,NSMAF,C12orf49,STXBP1,SESN3,CBX6,ASNA1,MAPK8IP2,FIG4,FYB,TXNRD1,BCL2L1,ADRA2A,NAGLU,TMX2,CBX3,TNS1,ETV5,SULF1,SCD,ZC3H7B,CARS,F2RL3,FAT3,NHP2,PKHD1L1,RPL7A,FILIP1,COL6A1,F8,C16orf59,IGSF8,AKR1C1/AKR1C2,TRIM55,IPO4,TRIM2,SOD1,SAA2,TSN,CFAP97,UTY,WIPF3,POLR3B,TBL1Y,C7orf43,MAP4K4,CPAMD8,ITGA8,ARPC5,RAN,CA12,GHITM,MKI67,EXPH5,ABCC6,SGPL1,C9orf91,LRFN5,LGMN,DUSP3,PRG4,ZNF605,FAM124B,PXK,POU6F2,KIF21A,MED16,ZBTB16,SV2B,PTP4A3,DKC1,CPNE4,ROR1,BCAP29,TSR3,FARSA,INPP4B,NCLN,RTN4,ME2,ARHGAP35,GSTP1,SORL1,PPP1R3C,LRP6,HYOU1,ST6GALNAC4,FKBP1A,GPC4,EAF1,CDH11,ENAH,CADM2,CES1,MYO5C,TTC7B,DIP2B,TUB,TXNL1,SMPD3,SLC30A1,LIMCH1,LAMB4,RPS24,PLXNA1,NAP1L4,NOL6,PTPRK,TRIM28,PAICS,TIAL1,LRRC8D,SNTG2,SLC48A1,BRINP2,RHBDD2,SREBF1,TREM2,AOX1,NCAM1,PLCB2,PFN1,GTF3C6,ARF1,PRMT3,MYH15,UNC5B,MAP1B,FAM127B,CHTOP,CNDP2,CAMK2D,PLCE1,DPP3,PABPC4,COMT,PCYT2,ANXA7,GOT1,GSK3B,RET,COL27A1,PCNXL2,C7orf50,MFSD3,HK1,FERMT3,THUMPD3,TRIOBP,CLTC,DGKE,FAM45A,SLC4A7,RPL12,ATP10A,GALNT13,GPAA1,TMEM176A,MAPT,RARRES3,NUAK1,TBC1D16,CYP4A11,ARL2,SPIRE1,SRM,FPR3,SH3RF3,RAB1A,ATF5,PCDHAC2,PCDH19,ILF2,MRPS30,THBS1,ERBB4,CYGB,ASAP3,OGDH,ATP5I,COL5A2,TMEM104,HSPH1,MAP3K1,R3HDM1,VSIG4,MRPS16,SYNPO2,PLXND1,ANO2,RPS4Y1,TMEM2,PLCB4,PAG1,ASAP2,GBE1,NUCB2,NCKAP1L,ADAM9,SEMA4B,GRPEL1,PPP2R1B,HLTF,MPV17,KLHDC8B,WHSC1,LRRC59,PCDHAC1,CLSTN2,SLC35C1,CLIP1,NPL,PTPRC,SRPX2,EIF4G2,KEAP1,KIF1A,ST6GALNAC2,SPTB,STAM,MGAT1,MRPL24,PLD3,PPP1R1B,CNR1,TMEM201,FGFR2,NPY5R,SMOC2,DES,SPATA20,HSPA8,TMEM127,CTSA,SCUBE1,MRNIP,DUSP4,CHD1L,SQSTM1,TMEM33,ESR2,TRAPPC5,FKBP2,APOE,NME1,SFXN4,FBXO10,CHCHD10,OSGIN1,CUBN,HS2ST1,HSPB8,PROX1,MMP25,SDK1,COL16A1,OGT,ACTR3,SORBS1,TNXB,ARFGAP1,OSBPL11,ALG8,SERPINA1,CSNK2B,NFE2L2,RPN1,S100A1,TMC2,SRA1,GNA12,SLC6A6,DGAT2,SLC39A6,XIST,CPEB4,TBC1D13,FOS,MYOC,NTRK3,FLNC,EIF4A1,DOPEY2,MBD3,PSAP,ARHGDIA,TTYH3,ABCC3,BMP6,C11orf68,PPIL1,ID4,PTER,MEGF9,MBP,ACO2,RACK1,TYMP,CES2,MRVI1,HSPA5,C3orf17,BIN1,NNMT,TMEM132C,RHOG,MEGF6,GDE1,ENTPD5,PACS2,FAR2,NUPR1,HOXA7,STAB1,BCAS2,FSTL3,LAMA2,KCNK2,TMC5,HNRNPAB,RAPGEF3,CAPG,THRA,DMXL2,KCNG1,TLN2,ADAM12,ALG3,CDH20,XRCC6,IGFBP3,PIK3AP1,MEGF8,PTGFR,UBXN1,ERAP2,RAB4A,SLC1A4,MSR1,SCARA5,MECR,LBHD1,HNRNPK,VPS4A,REXO2,MLH1,IRAK1,SHC1,TWF2,PREPL,DNAJC4,FAM166A,IARS,LONP1,ATP13A2,FAM171B,VCAM1,AGFG1,EDNRB,ZNF358,NQO1,HPS1,MGAT5,TRPA1,HSPD1,PSME3,AIFM2,NFE2L1,ATIC,SHB,KDM5D,KIF5B,PSMD2,SLC36A1,NOP16,MUC17,TBC1D7,EMC3,IVD,CADM3,SLC29A4,PMVK,APOB,LDB3,SH3BGRL3,HRAS,PCDH7,SH3GLB1,KPNA1,CHST2,BCAT1,DYNLL1,DGCR6L,ABCC1,RPS2,TXN,CALCRL,TMEM9B,AASS,TSPAN33,KIAA0100,CTPS1,NR1D1,BSG,YARS,MAP2K3,LRP8,SFRP1,TCF7,CYR61,C3AR1,ALDH4A1,MSC,ADAM17,RALA,TMEM129,NID2,UBQLN1,CTNNA1,PFKL,TTC1,DCLK1,UCHL1,DCLK2,MACC1,LIPA,C1QTNF3,TOP2A,SAMD1,PSMD14,SARS,AMFR,PLOD3,MYH1,DNAH12,LETM1,ADRM1,DTX4,IMPDH2,ACTB,ATXN2L,WDR12,COPG1,AREL1,FTL,DOCK8,PPP1R16B,ADCY1,ARAP1,P2RY12,CBX4,PLAU,RUFY3,ACTR1A,EFR3A,MVD,CXCL12,MMRN1,SDC4,DYNLT1,SLC7A5,RAD51C,CLCN3,MRPL43,EIF2AK1,PTX3,TBC1D2B,KLHL11,SPP1,SGCG,ANLN,RAB10,UQCR11,MARS,PKN1,EPRS,TIE1,LMCD1,SEL1L,EFS,PPP2R1A,PLEKHH2,GNL3,STXBP5,RNPEP,LEP,EPB41L3,MMP14,PKM,SLC7A1,CFTR,FAM47E,HIF1A,STXBP4,GANAB,SEPHS2,HMOX1,NLK,PCK2,FLNA,KCNMA1,ANXA1,EFNB1,F5,TGFB2,SENP3,KIT,HSD11B2,ARHGEF2,NR2F6,BHMT2,ALPL,STK40,HMGCS1,ACTN1,PRNP,SEMA3E,FRMD1,ADCY2,C10orf71,CENPV,CYP27A1,RARS2,AP3D1,COPS7A,NXPH4,GABBR1,ZBTB7C,CSF1R,SLC5A3,WARS,TNFAIP8L2,DIP2C,LPAR1,OLFML2B,PANK3,CLDN2,MAT2A,USP9Y,RTN3,CARM1,MMP9	608	
Liver Fibrosis	fibrosis	fibrosis of liver	1.76E-02	 	-1.166	 	-0.581	SCD,APOE,SOCS3,SPP1,LEP,DDIT3,LRP6,RACK1,FGFR2,CEBPB,NFE2L1,HMOX1,SREBF1,TGFB2,CTSB,NAGLU,STAB1,PLAU,NFE2L2,GSTP1	20	
Liver Cirrhosis	primary biliary cirrhosis	early stage primary biliary cirrhosis	1.84E-02	 	 	 	 	APOB,SREBF2,NR1H3	3	
Cardiac Necrosis/Cell Death	survival	survival of ventricular myocytes	1.84E-02	 	 	 	 	CALR,ADIPOQ,HSPB6	3	
Cardiac Dysfunction	dysfunction	dysfunction of left ventricle	1.93E-02	 	1.664	 	1.737	PTX3,FSTL3,CSF1,CYBB,PLAU,MMP9	6	
Liver Necrosis/Cell Death	cell death	cell death of hepatocytes	2.05E-02	 	-0.559	 	-0.361	SLC20A1,SCD,SOCS3,DDIT3,TNFRSF1A,ADIPOQ,HRAS,UGCG,TMBIM6,FAS,RBCK1,TACR1,FOS,SHC1,HMOX1,BCL2L1,IL1RN,ENTPD5,BMF,SAA1,CTSB,GSK3B,SLC25A5,NFE2L2	24	
Cardiac Dilation	dilation	dilation of heart chamber	2.10E-02	 	0.194	 	0.619	GAB2,MARCKSL1,CAMK2D,CAPNS1,PLCE1,SPP1,FSTL3,NUPR1,PLAU,MMP9	10	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart cells	2.18E-02	 	0.722	 	0.268	CTGF,LEP,RAB1A,FSTL3,HDAC2,GDF15,HSPB8,ADIPOQ,PPIA,RAPGEF3,SLC9A1,H2AFZ,LMCD1,CTSD,SHC1,CAMK2D,PLCE1,DUSP1,CTSB,PRMT5,MAP2K3,GSK3B,PLAU,MMP9	24	
Cardiac Proliferation	proliferation	proliferation of cardiomyocytes	2.19E-02	 	-0.180	 	-0.336	ADAM17,CALCRL,LEP,RAB1A,HDAC2,KCNK2,FGF1,HMOX1,PLCE1,DUSP1,ALDH1A2,KIT,HSD11B2,GSK3B	14	
Renal Inflammation, Renal Nephritis	Goodpasture's syndrome	Goodpasture's syndrome	2.20E-02	 	 	 	 	DDIT3,ASNS	2	
Liver Cholestasis	accumulation	accumulation of bile acid	2.20E-02	 	 	 	 	ABCB11,NFE2L2	2	
Liver Steatosis	hepatic steatosis	advanced stage hepatic steatosis	2.20E-02	 	 	 	 	LEP,SPP1	2	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of renal tubule	2.20E-02	 	 	 	 	LGMN,HSD11B2	2	
Renal Dysplasia, Renal Hypoplasia	renal hypodysplasia/aplasia type 1	renal hypodysplasia/aplasia type 1	2.20E-02	 	 	 	 	ITGA8,RET	2	
Liver Cholestasis	secretion	secretion of taurocholic acid	2.20E-02	 	 	 	 	HMOX1,ABCB11	2	
Glomerular Injury	size	size of glomerular crescent	2.20E-02	 	 	 	 	PLAU,PLAT	2	
Glomerular Injury, Kidney Failure, Renal Fibrosis	tubulo-interstitial fibrosis	tubulo-interstitial fibrosis of skeletal muscle	2.20E-02	 	 	 	 	SGCG,MMP14	2	
Congenital Heart Anomaly	ventricular septal defect type 3	ventricular septal defect type 3	2.20E-02	 	 	 	 	TGFB2,GPC3	2	
Cardiac Arrythmia	atrial fibrillation	atrial fibrillation	2.29E-02	 	 	 	 	VCAM1,TUBB4B,TUBG1,TUBB2A,DGAT2,THRA,NPC1L1,VKORC1,ADRA2A,KCNMA1,P2RY12,ANXA7,TUBA1C,CHI3L1,TFPI,MMP9,ADRA1A,PLAT	18	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiac muscle	2.46E-02	 	1.100	 	0.544	CTGF,LEP,RAB1A,PFKFB1,FSTL3,HDAC2,GDF15,HSPB8,ADIPOQ,PPIA,RAPGEF3,SLC9A1,H2AFZ,LMCD1,SHC1,MTPN,CAMK2D,PLCE1,DUSP1,PRMT5,MAP2K3,GSK3B,PLAU,MMP9	24	
Kidney Failure	acute renal failure	acute renal failure	2.65E-02	 	 	 	 	CD28,HMOX1,SLC7A11,SPP1,ADRA2A,TOP2A,CYR61,GSS,ADRA1A,GSTP1	10	
Cardiac Arrythmia	cardiac fibrillation	cardiac fibrillation	2.68E-02	 	 	 	 	VCAM1,TUBB4B,TUBG1,TUBB2A,DGAT2,THRA,NPC1L1,ADRA2A,VKORC1,KCNMA1,P2RY12,ANXA7,TUBA1C,NHLH1,CHI3L1,TFPI,DSP,MMP9,ADRA1A,PLAT	20	
Liver Adhesion	adhesion	adhesion of liver cells	2.75E-02	 	 	 	 	VCAM1,CTGF,ADAM12	3	
Liver Hyperplasia/Hyperproliferation	proliferation	proliferation of liver cancer cells	2.78E-02	 	0.928	 	0.379	SOCS3,LEP,PEG10,HDAC2,GPC3,ODC1	6	
Cardiac Damage	damage	damage of heart	2.83E-02	 	-0.460	bias	0.489	HMOX1,ANXA1,GDF15,CTNNA1,ADIPOQ,ATF4,MAP2K3,TXN,PLAU,SGCD,SLC9A1,MMP9	12	
Glomerular Injury, Kidney Failure, Renal Fibrosis	interstitial fibrosis	interstitial fibrosis of kidney	2.95E-02	Decreased	-2.157	bias	-0.789	LGMN,PHB,SGCG,GLIS2,TNFRSF1A,MMP14,ADIPOQ,APRT,CD151	9	
Pulmonary Hypertension	pulmonary hypertensive arterial disease	pulmonary hypertensive arterial disease	2.95E-02	 	 	 	 	APOE,BCL2L1,FHL1,EDNRB,KIT,P2RY12,RET,CSF1R,G6PC3	9	
Liver Inflammation/Hepatitis, Liver Steatosis	steatohepatitis	steatohepatitis	3.27E-02	 	0.447	bias	 	LEP,APOB,TNFRSF1A,LRP6,ADIPOQ,CD14,SOD1,NFE2L1	8	
Cardiac Dilation	dilation	dilation of heart ventricle	3.31E-02	 	0.508	 	0.857	GAB2,MARCKSL1,CAMK2D,CAPNS1,PLCE1,SPP1,FSTL3,PLAU,MMP9	9	
Kidney Failure	failure	failure of kidney	3.51E-02	Decreased	-2.069	bias	-0.433	APOB,SLC7A11,MMP14,RRM2B,ADIPOQ,FKBP1A,GSS,APRT,CD28,HMOX1,LGMN,GBA,PHB,THBS1,TOP2A,SPP1,SGCG,TNFRSF1A,IMPDH2,FCGR2A,GLIS2,ADRA2A,DUSP1,FCER1G,P2RY12,ARHGDIA,CYR61,TFPI,TNS1,GSTP1,ADRA1A,CD151	32	
Renal Necrosis/Cell Death	cell viability	cell viability of kidney cell lines	3.72E-02	 	0.429	 	-0.319	SGPL1,TFEB,MAPT,ANXA5,ITGAV,HYOU1,PPIA,PRKCE,RET,VDAC1,ABCC3,APP	12	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cells	3.96E-02	Decreased	-2.007	 	-1.612	SLC20A1,SCD,SOCS3,TNFRSF1A,ADIPOQ,HRAS,TMBIM6,CEBPB,FAS,RBCK1,PTPRC,TACR1,SHC1,BCL2L1,ARF6,SERPINH1,ENTPD5,BMF,SAA1,ITGAV,CTSB,GSK3B,MMP9	23	
Glomerular Injury	formation	formation of glomerular crescent	3.96E-02	 	-1.109	bias	-0.233	HMOX1,C1QA,PLAU,PLAT,CD151	5	
Liver Damage, Liver Inflammation/Hepatitis	hepatitis C	hepatitis C	4.05E-02	 	 	 	 	PTPRC,POR,BCL2L1,LEP,SPP1,IMPDH2,CSF1,GAA,ADIPOQ,LGALS9,GABBR1,FKBP1A	12	
Cardiac Fibrosis	fibrosis	fibrosis of heart	4.11E-02	 	0.960	 	2.018	APOE,PFKFB1,RRM2B,CTNNA1,HSPB8,HRAS,HMOX1,NDUFS6,CYBB,PNKD,GSK3B,DSP,PLAT,PTX3,SPP1,SGCG,FSTL3,NPY1R,EGR1,DES,CAPNS1,ADRA2A,LIMS1,PLAU,SGCD,MMP9	26	
Cardiac Arteriopathy	coronary occlusion	coronary occlusion	4.15E-02	 	 	 	 	APOE,SGCD	2	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal tubule	4.15E-02	 	 	 	 	GLIS2,APRT	2	
Liver Cholestasis	lipopolysaccharide hepatocellular cholestasis	lipopolysaccharide hepatocellular cholestasis	4.15E-02	 	 	 	 	CD68,GJB2	2	
Cardiac Necrosis/Cell Death	necrosis	necrosis of myocardium	4.15E-02	 	 	 	 	SGCD,PLAT	2	
Cardiac Arrythmia	supraventricular arrhythmia	supraventricular arrhythmia	4.22E-02	 	 	 	 	CALR,VCAM1,TUBB4B,TUBG1,TUBB2A,DGAT2,THRA,NPC1L1,ADRA2A,VKORC1,KCNMA1,P2RY12,ANXA7,TUBA1C,CHI3L1,TFPI,MMP9,ADRA1A,PLAT	19	
Liver Cirrhosis	cirrhosis	cirrhosis of liver	4.32E-02	 	 	 	 	CTGF,APOB,SPP1,LEP,SLC4A2,FST,NQO1,NR1H3,HNRNPK,FGF1,BSG,VKORC1,SREBF2,ABCC1,TGFB2,NR4A1,ABCB11,SERPINA1,GCLM,ABCC3,ALPL,NFE2L2,ADRA1A,MMP9	24	
Cardiac Arrythmia	arrhythmia	arrhythmia	4.46E-02	 	-0.963	 	-0.742	PTGFR,KCND3,BAG3,HRAS,NPC1L1,KCNMA1,ANXA7,TUBA1C,TXN,DSP,PLAT,SLC2A5,CALR,VCAM1,TUBB4B,TUBG1,TUBB2A,DGAT2,THRA,DES,CALM1 (includes others),VKORC1,ADRA2A,P2RY12,TMEM43,NHLH1,TFPI,CHI3L1,ADRA1A,MMP9	30	
Glomerular Injury	glomerulosclerosis	glomerulosclerosis	4.48E-02	Decreased	-2.800	bias	-1.279	APOE,SPP1,SGCG,TNFRSF1A,ANLN,MMP14,RRM2B,ADIPOQ,APRT,HMOX1,LGMN,PHB,GLIS2,SREBF1,STAB1,ARHGDIA,TNS1,MPV17,CD151	19	
Cardiac Infarction	ST-elevation myocardial infarction	ST-elevation myocardial infarction	4.68E-02	 	 	 	 	PTX3,ITGAV,P2RY12,NPC1L1	4	
Pulmonary Hypertension	pulmonary hypertension	Pulmonary Hypertension	4.88E-02	 	 	 	 	APOE,BCL2L1,FHL1,EDNRB,F8,ADRA2A,IL1RN,KIT,P2RY12,RET,CSF1R,SLC9A1,G6PC3	13	
Cardiac Output	cardiac output	cardiac output of heart	5.16E-02	 	 	 	 	NDUFS6,HRAS,ADRA1A	3	
Increased Levels of Potassium	excretion	increased excretion of K+	5.70E-02	 	 	 	 	LEP,HSD11B2,AKR1B1,CYP4A11	4	
Cardiac Necrosis/Cell Death	cell viability	cell viability of cardiomyocytes	5.85E-02	 	0.463	bias	-0.198	CALR,HSPB8,ADIPOQ,GSK3B,HSPD1,HSPB6	6	
Liver Regeneration	regeneration	regeneration of liver	6.06E-02	 	1.841	bias	0.482	SOCS3,LEP,TNFRSF1A,IL1RN,EGR1,PLAU,CEBPB,GPC3,NFE2L2,C3AR1,ODC1,MMP9	12	
Pulmonary Hypertension	chronic thromboembolic pulmonary hypertension	chronic thromboembolic pulmonary hypertension	6.52E-02	 	 	 	 	EDNRB,P2RY12	2	
Renal Inflammation, Renal Nephritis	experimental crescentic glomerulonephritis	experimental crescentic glomerulonephritis	6.52E-02	 	 	 	 	SPP1,IL1RN	2	
Renal Inflammation, Renal Nephritis	immune complex nephritis	immune complex nephritis	6.52E-02	 	 	 	 	IL1RN,FAS	2	
Cardiac Dysfunction	left ventricular systolic dysfunction	left ventricular systolic dysfunction	6.52E-02	 	 	 	 	FSTL3,CYBB	2	
Cardiac Pulmonary Embolism	acute pulmonary embolism	acute pulmonary embolism	6.64E-02	 	 	 	 	P2RY12,TFPI,PLAT	3	
Renal Atrophy	atrophy	atrophy of renal cortex	6.64E-02	 	 	 	 	LGMN,GPC3,APRT	3	
Liver Proliferation	proliferation	proliferation of hepatocytes	6.67E-02	Increased	2.793	 	2.092	SLC20A1,SOCS3,TNFRSF1A,CXCL12,HRAS,FGFR2,PROX1,CEBPB,GPC3,ODC1,FAS,TNFRSF12A,FOS,CCND3,THBS1,IL1RN,ENTPD5,CXCL14,SLC7A5,GSK3B,NFE2L2	21	
Cardiac Inflammation	pericarditis	pericarditis	6.84E-02	 	 	 	 	TUBB4B,TUBG1,TUBB2A,TUBA1C	4	
Cardiac Fibrosis	fibrosis	fibrosis of heart ventricle	7.41E-02	 	1.432	 	1.432	PTX3,ADRA2A,CTNNA1,CYBB,GSK3B	5	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of kidney	7.41E-02	Decreased	-2.236	bias	 	LGMN,HSD11B2,CEBPB,PKN1,CD151	5	
Increased Levels of Hematocrit	hematocrit	increased hematocrit of organism	7.48E-02	 	 	 	 	FERMT3,SLC4A4,APOE,SPP1,PRDX1,TSPAN33,APRT,NFE2L1,HMOX1,LGMN,ATF4,NFE2L2,STEAP3	13	
Cardiac Infarction	acute myocardial infarction	acute myocardial infarction	7.86E-02	 	 	 	 	PTX3,FCGR2A,TUBB4B,TUBG1,TUBB2A,ADIPOQ,CXCL12,F13A1,NPC1L1,APP,ITGAV,P2RY12,TUBA1C,PLAT	14	
Liver Inflammation/Hepatitis	acute hepatitis	acute hepatitis	8.08E-02	 	 	 	 	TNFRSF1A,CSF1,NAGLU,MMP9	4	
Cardiac Arrythmia	arrhythmogenic right ventricular dysplasia	arrhythmogenic right ventricular dysplasia	8.08E-02	 	 	 	 	BAG3,TMEM43,DES,DSP	4	
Liver Hypoplasia	hypoplasia	hypoplasia of liver	8.11E-02	Decreased	-2.630	bias	 	SLC20A1,ARF6,TCEA1,CDK6,ATF4,EIF6,MAFG	7	
Cardiac Infarction	infarction	infarction of heart	8.29E-02	 	 	 	 	BCL2L1,CSF1,PRKCE	3	
Cardiac Proliferation	proliferation	proliferation of ventricular myocytes	8.29E-02	 	 	 	 	PLCE1,RAB1A,LEP	3	
Cardiac Fibrosis	interstitial fibrosis	interstitial fibrosis of heart	8.46E-02	 	1.067	 	0.905	PTX3,CAPNS1,FSTL3,CYBB,HRAS	5	
Cardiac Arrythmia	Brugada syndrome type 10	Brugada syndrome type 10	8.84E-02	 	 	 	 	KCND3	1	
Congenital Heart Anomaly	Burn-McKeown syndrome	Burn-McKeown syndrome	8.84E-02	 	 	 	 	TXNL4A	1	
Pulmonary Hypertension	Dursun syndrome	Dursun syndrome	8.84E-02	 	 	 	 	G6PC3	1	
Congenital Heart Anomaly	Ogden syndrome	Ogden syndrome	8.84E-02	 	 	 	 	NAA10	1	
Hepatocellular Peroxisome Proliferation	activation	activation of PPARA in liver cells	8.84E-02	 	 	 	 	PLIN2	1	
Cardiac Infarction	acute periprocedural myocardial infarction	acute periprocedural myocardial infarction	8.84E-02	 	 	 	 	P2RY12	1	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	advanced stage nonalcoholic steatohepatitis	8.84E-02	 	 	 	 	LEP	1	
Liver Cirrhosis	alpha-1 antitrypsin deficiency related emphysema-cirrhosis	alpha-1 antitrypsin deficiency related emphysema-cirrhosis	8.84E-02	 	 	 	 	SERPINA1	1	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of left ventricle	8.84E-02	 	 	 	 	GSK3B	1	
Cardiac Arteriopathy	autosomal dominant coronary artery disease type 2	autosomal dominant coronary artery disease type 2	8.84E-02	 	 	 	 	LRP6	1	
Liver Cholestasis	benign recurrent intrahepatic cholestasis 2	benign recurrent intrahepatic cholestasis 2	8.84E-02	 	 	 	 	ABCB11	1	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 4	catecholaminergic polymorphic ventricular tachycardia type 4	8.84E-02	 	 	 	 	CALM1 (includes others)	1	
Liver Inflammation/Hepatitis	hepatitis	chronic phase hepatitis	8.84E-02	 	 	 	 	HLA-A	1	
Cardiac Hypertrophy	concentric hypertrophy of left ventricle	concentric hypertrophy of left ventricle	8.84E-02	 	 	 	 	PLIN5	1	
Renal Degeneration	degeneration	degeneration of renal tubular epithelial cells	8.84E-02	 	 	 	 	ARHGDIA	1	
Renal Degradation	degradation	degradation of renal tubule	8.84E-02	 	 	 	 	PSAP	1	
Cardiac Dysfunction	dysfunction	dysfunction of myocardium	8.84E-02	 	 	 	 	LEP	1	
Cardiac Dysplasia	dysplasia	dysplasia of right ventricle	8.84E-02	 	 	 	 	RPSA	1	
Cardiac Hypertrophy	cardiac hypertrophy	early stage cardiac hypertrophy	8.84E-02	 	 	 	 	RAPGEF3	1	
Liver Inflammation/Hepatitis, Liver Steatosis	experimental nonalcoholic steatohepatitis	experimental nonalcoholic steatohepatitis	8.84E-02	 	 	 	 	ADIPOQ	1	
Cardiac Arrythmia	familial arrhythmogenic right ventricular dysplasia type 5	familial arrhythmogenic right ventricular dysplasia type 5	8.84E-02	 	 	 	 	TMEM43	1	
Cardiac Arrythmia	familial arrhythmogenic right ventricular dysplasia type 8	familial arrhythmogenic right ventricular dysplasia type 8	8.84E-02	 	 	 	 	DSP	1	
Cardiac Fibrosis	fibrosis	fibrosis of right ventricle	8.84E-02	 	 	 	 	CTNNA1	1	
Glomerular Injury	focal segmental glomerulosclerosis type 8	focal segmental glomerulosclerosis type 8	8.84E-02	 	 	 	 	ANLN	1	
Liver Steatosis	hepatic steatosis	grade 2-3 hepatic steatosis	8.84E-02	 	 	 	 	SREBF1	1	
Liver Fibrosis	hepatic fibrosis	grade 3-4 hepatic fibrosis	8.84E-02	 	 	 	 	SREBF1	1	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of distal convoluted tubule	8.84E-02	 	 	 	 	HSD11B2	1	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of proximal tubule cells	8.84E-02	 	 	 	 	LGMN	1	
Renal Hypertrophy	hypertrophy	hypertrophy of distal convoluted tubule	8.84E-02	 	 	 	 	HSD11B2	1	
Increased Levels of Albumin	export	increased export of albumin	8.84E-02	 	 	 	 	RAN	1	
Increased Levels of Albumin	secretion	increased secretion of albumin	8.84E-02	 	 	 	 	APP	1	
Liver Cirrhosis	indian childhood cirrhosis	indian childhood cirrhosis	8.84E-02	 	 	 	 	UTP4	1	
Cardiac Infarction	infarction	infarction of myocardium	8.84E-02	 	 	 	 	CSF1	1	
Renal Inflammation, Renal Nephritis	inflammation	inflammation of renal tubule	8.84E-02	 	 	 	 	APRT	1	
Liver Cholestasis	intrahepatic cholestasis of pregnancy type 2	intrahepatic cholestasis of pregnancy type 2	8.84E-02	 	 	 	 	ABCB11	1	
Glomerular Injury	lipoprotein glomerulopathy	lipoprotein glomerulopathy	8.84E-02	 	 	 	 	APOE	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 14	long QT syndrome type 14	8.84E-02	 	 	 	 	CALM1 (includes others)	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 15	long QT syndrome type 15	8.84E-02	 	 	 	 	CALM1 (includes others)	1	
Congenital Heart Anomaly	multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects	multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects	8.84E-02	 	 	 	 	B3GAT3	1	
Cardiac Degeneration	myocytolysis	myocytolysis of heart	8.84E-02	 	 	 	 	MMP9	1	
Liver Inflammation/Hepatitis	necroinflammatory liver disease	necroinflammatory liver disease	8.84E-02	 	 	 	 	ADIPOQ	1	
Nephrosis	nephronophthisis 7	nephronophthisis 7	8.84E-02	 	 	 	 	GLIS2	1	
Renal Inflammation, Renal Nephritis	nephropathy with pretibal epidermolysis bullosa and deafness	nephropathy with pretibal epidermolysis bullosa and deafness	8.84E-02	 	 	 	 	CD151	1	
Nephrosis	nephrotic syndrome type 3	nephrotic syndrome type 3	8.84E-02	 	 	 	 	PLCE1	1	
Nephrosis	nephrotic syndrome type 8	nephrotic syndrome type 8	8.84E-02	 	 	 	 	ARHGDIA	1	
Liver Hyperplasia/Hyperproliferation	nodular hyperplasia	nodular hyperplasia of liver	8.84E-02	 	 	 	 	SOD1	1	
Cardiac Necrosis/Cell Death	apoptosis	onset of apoptosis of cardiomyocytes	8.84E-02	 	 	 	 	LEP	1	
Cardiac Hypertrophy	hypertrophy	onset of hypertrophy of cardiomyocytes	8.84E-02	 	 	 	 	LEP	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis B	persistent chronic hepatitis B	8.84E-02	 	 	 	 	CSF1	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis C	persistent chronic hepatitis C	8.84E-02	 	 	 	 	CSF1	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	recurrent hepatocellular carcinoma	recurrent hepatocellular carcinoma	8.84E-02	 	 	 	 	HNRNPAB	1	
Cardiac Damage	rupture	rupture of ventricular septum	8.84E-02	 	 	 	 	CTNNA1	1	
Glomerular Injury, Kidney Failure, Renal Fibrosis	tubulo-interstitial fibrosis	tubulo-interstitial fibrosis of renal cortex	8.84E-02	 	 	 	 	GLIS2	1	
Renal Dilation	vasodilation	vasodilation of renal artery	8.84E-02	 	 	 	 	MMP9	1	
Cardiac Dilation	dilation	dilation of left ventricle	8.95E-02	 	-0.113	 	0.241	GAB2,MARCKSL1,CAPNS1,SPP1,FSTL3,PLAU,MMP9	7	
Renal Proliferation	growth	arrest in growth of kidney cell lines	9.22E-02	 	 	 	 	FOS,HRAS	2	
Heart Failure	end stage heart failure	end stage heart failure	9.22E-02	 	 	 	 	PARK7,RAPGEF3	2	
Renal Transformation	transformation	transformation of kidney cells	9.22E-02	 	 	 	 	HRAS,EIF2S1	2	
Cardiac Dysfunction	dysfunction	dysfunction of heart	9.33E-02	Increased	2.137	 	2.330	PTX3,SCD,APOE,LEP,FSTL3,CSF1,CYBB,DUSP4,PLAU,DSP,MMP9	11	
Cardiac Fibrosis	fibrosis	fibrosis of myocardium	9.43E-02	 	0.577	 	0.971	PLAU,SGCD,DSP,MMP9	4	
Increased Levels of ALT	localization	increased localization of ALT	9.43E-02	 	 	 	 	APOE,ITGB2,SAA1,C1QA	4	
Liver Inflammation/Hepatitis	experimental hepatitis	experimental hepatitis	1.01E-01	 	 	 	 	SCD,LEP,FAS	3	
Increased Levels of Red Blood Cells	quantity	increased quantity of red blood cells	1.08E-01	 	 	 	 	EIF2AK1,DNASE2,MAF,CDK6,SLC7A1,TSPAN33,SOD1,HMOX1,CCND2,LGMN,CCND3,APEX2,NFE2L2	13	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis C	chronic hepatitis C	1.09E-01	 	 	 	 	POR,BCL2L1,LEP,SPP1,IMPDH2,CSF1,GAA,ADIPOQ,LGALS9	9	
Renal Hypertrophy	hypertrophy	hypertrophy of kidney	1.17E-01	 	-0.378	 	0.115	PARK7,BAG6,ADIPOQ,NUPR1,HSD11B2,STAB1,CEBPB	7	
Liver Damage	damage	damage of hepatocytes	1.20E-01	 	 	 	 	IL1RN,EGR1,PLAU	3	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney component	1.20E-01	 	 	 	 	GLIS2,STAB1,APRT	3	
Kidney Failure, Liver Failure	hepatorenal syndrome	hepatorenal syndrome	1.20E-01	 	 	 	 	ADRA2A,TOP2A,ADRA1A	3	
Increased Levels of Creatinine	clearance	increased clearance of creatinine	1.20E-01	 	 	 	 	EDNRB,ARHGDIA,APRT	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	progressive liver metastasis	1.20E-01	 	 	 	 	KIT,FGFR2,RET	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	symptomatic stage iodine-refractory liver metastasis	1.20E-01	 	 	 	 	KIT,FGFR2,RET	3	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction	1.21E-01	 	 	 	 	SCD,CTGF,LEP,CYBB,HRAS	5	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney	1.21E-01	Decreased	-2.546	bias	-1.270	LGMN,SPP1,PHB,SGCG,GLIS2,TNFRSF1A,MMP14,ADIPOQ,STAB1,APRT,CD151	11	
Cardiac Fibrosis	interstitial fibrosis	interstitial fibrosis of left ventricle	1.22E-01	 	 	 	 	PTX3,CYBB	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	advanced stage hepatocellular carcinoma	1.24E-01	 	 	 	 	POR,TOP2A,KIT,RET	4	
Liver Damage	damage	damage of liver cells	1.24E-01	 	-0.152	 	-0.509	TNFRSF1A,IL1RN,EGR1,PLAU	4	
Cardiac Fibrosis	fibrosis	fibrosis of left ventricle	1.24E-01	 	1.980	 	1.857	PTX3,ADRA2A,CYBB,GSK3B	4	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of kidney cells	1.24E-01	Decreased	-2.000	bias	 	LGMN,CEBPB,PKN1,CD151	4	
Cardiac Necrosis/Cell Death	cell death	cell death of heart ventricle	1.26E-01	 	0.505	 	0.602	S100A1,ADIPOQ,RTN4,GSK3B,HSPB6,ADRA1A	6	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of renal glomerulus	1.26E-01	 	0.000	 	0.528	PARK7,BAG6,ADIPOQ,NUPR1,STAB1,CEBPB	6	
Renal Necrosis/Cell Death	cell death	cell death of renal glomerulus	1.37E-01	 	-0.707	 	-0.638	APOE,GFPT1,CTGF,CCNI,DUSP1,C1QA,PLAU,PLAT	8	
Cardiac Output	cardiac output	cardiac output	1.38E-01	 	0.447	bias	-0.587	APOE,EDNRB,NDUFS6,HRAS,ADRA1A,MMP9	6	
Liver Hyperplasia/Hyperproliferation	growth	growth of liver tumor	1.38E-01	 	1.054	bias	0.245	SOCS3,LEP,PEG10,HDAC2,PROX1,GPC3,ODC1	7	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of mesangial cells	1.40E-01	 	0.000	 	-0.124	APOE,GFPT1,CTGF,DUSP1	4	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	crescentic glomerulonephritis	1.41E-01	 	 	 	 	VCAM1,SPP1,IL1RN	3	
Increased Levels of AST	localization	increased localization of AST	1.41E-01	 	 	 	 	APOE,SAA1,FAS	3	
Cardiac Inflammation	carditis	carditis	1.44E-01	 	-1.000	 	-0.621	ITGB2,TUBB4B,ANXA1,TUBG1,TUBB2A,ADIPOQ,TUBA1C,KLF2,MMP9	9	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart ventricle	1.48E-01	 	1.133	 	1.189	S100A1,ADIPOQ,RTN4,GSK3B,ADRA1A	5	
Renal Damage	injury	injury of kidney	1.52E-01	 	-0.632	 	-1.095	LEP,THBS1,FCGR2A,SREBF1,SLC6A6,UNC5B,ARHGDIA,ANXA7,MAP2K3,C3AR1,PLAT	11	
Renal Inflammation, Renal Nephritis	pyelonephritis	pyelonephritis	1.53E-01	 	 	 	 	TOP2A,APRT	2	
Liver Regeneration	regeneration	regeneration of hepatocytes	1.53E-01	 	 	 	 	PLAU,MMP9	2	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatocytes	1.53E-01	 	-1.332	 	-1.027	SLC20A1,SOCS3,SCD,TNFRSF1A,ADIPOQ,HRAS,TMBIM6,FAS,RBCK1,TACR1,SHC1,BCL2L1,ENTPD5,BMF,SAA1,CTSB,GSK3B	17	
Liver Damage	hepatotoxicity	hepatotoxicity	1.62E-01	 	 	 	 	SLC7A11,TNFRSF1A,NFE2L2,GSS,FAS	5	
Glutathione Depletion In Liver	quantity	quantity of glutathione in liver	1.63E-01	 	 	 	 	LEP,NFE2L2,CERS2	3	
Nephrosis	nephrosis	nephrosis	1.67E-01	 	 	 	 	PLCE1,GLIS2,IMPDH2,ANXA1,CLTC,ZNF592,FKBP1A,ARHGDIA,ATP6V1A,GSTP1	10	
Cardiac Arrythmia	Brugada syndrome type 9	Brugada syndrome type 9	1.69E-01	 	 	 	 	KCND3	1	
Liver Hyperbilirubinemia	Dubin-Johnson syndrome	Dubin-Johnson syndrome	1.69E-01	 	 	 	 	ABCC3	1	
Nephrosis	Galloway Mowat syndrome	Galloway Mowat syndrome	1.69E-01	 	 	 	 	ZNF592	1	
Liver Cholestasis	accumulation	accumulation of taurocholic acid	1.69E-01	 	 	 	 	ABCB11	1	
Renal Inflammation, Renal Nephritis	acute proliferative glomerulonephritis	acute proliferative glomerulonephritis	1.69E-01	 	 	 	 	MAPKAPK2	1	
Renal Inflammation, Renal Nephritis	acute pyelonephritis	acute pyelonephritis	1.69E-01	 	 	 	 	TOP2A	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of sinusoidal endothelial cells	1.69E-01	 	 	 	 	FAS	1	
Cardiac Arteriopathy	atherosclerosis	atherosclerosis of coronary artery	1.69E-01	 	 	 	 	APOE	1	
Liver Hyperplasia/Hyperproliferation	beta-catenin activating mutation positive hepatocellular adenoma	beta-catenin activating mutation positive hepatocellular adenoma	1.69E-01	 	 	 	 	GLUL	1	
Liver Cholestasis, Liver Inflammation/Hepatitis	cholestatic alcoholic hepatitis	cholestatic alcoholic hepatitis	1.69E-01	 	 	 	 	ABCB11	1	
Cardiac Degeneration	degeneration	degeneration of heart tissue	1.69E-01	 	 	 	 	SGCD	1	
Liver Necrosis/Cell Death	cell death	delay in cell death of hepatocytes	1.69E-01	 	 	 	 	FAS	1	
Congenital Heart Anomaly	double inlet heart left ventricle	double inlet heart left ventricle	1.69E-01	 	 	 	 	TGFB2	1	
Liver Cholestasis	drug-induced cholestasis	drug-induced cholestasis	1.69E-01	 	 	 	 	ABCB11	1	
Liver Cholestasis	ethynylestradiol hepatocellular cholestasis	ethynylestradiol hepatocellular cholestasis	1.69E-01	 	 	 	 	GJB2	1	
Liver Proliferation	expansion	expansion of oval cells	1.69E-01	 	 	 	 	TNFRSF12A	1	
Liver Steatosis	experimental nonalcoholic fatty liver disease	experimental nonalcoholic fatty liver disease	1.69E-01	 	 	 	 	ADIPOQ	1	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of tubulointerstitium	1.69E-01	 	 	 	 	GLIS2	1	
Liver Necrosis/Cell Death	focal necrosis	focal necrosis of liver cells	1.69E-01	 	 	 	 	APOE	1	
Glomerular Injury	glomerular cyst	glomerular cyst	1.69E-01	 	 	 	 	LGMN	1	
Glomerular Injury, Renal Degeneration	hyalinization	hyalinization of renal glomerulus	1.69E-01	 	 	 	 	SREBF1	1	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular septum	1.69E-01	 	 	 	 	MYL9	1	
Increased Levels of Albumin	flux	increased flux of albumin	1.69E-01	 	 	 	 	THBS1	1	
Liver Failure	infantile liver failure syndrome type 2	infantile liver failure syndrome type 2	1.69E-01	 	 	 	 	MARS	1	
Glomerular Injury	lipidosis	lipidosis of renal glomerulus	1.69E-01	 	 	 	 	APOE	1	
Liver Inflammation/Hepatitis	alcoholic hepatitis	mild alcoholic hepatitis	1.69E-01	 	 	 	 	TNFRSF1A	1	
Cardiac Arrythmia	non-valvular atrial fibrillation	non-valvular atrial fibrillation	1.69E-01	 	 	 	 	VKORC1	1	
Kidney Failure	progressive myoclonic epilepsy type 4 with renal failure	progressive myoclonic epilepsy type 4 with renal failure	1.69E-01	 	 	 	 	GBA	1	
Cardiac Proliferation	proliferation	proliferation of adventitial fibroblasts	1.69E-01	 	 	 	 	ADIPOQ	1	
Cardiac Proliferation	proliferation	proliferation of cardiac stem cells	1.69E-01	 	 	 	 	GNL3	1	
Liver Proliferation	proliferation	proliferation of hepatic progenitor cells	1.69E-01	 	 	 	 	PROX1	1	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells/myofibroblasts	1.69E-01	 	 	 	 	CTSB	1	
Cardiac Pulmonary Embolism	pulmonary embolism	pulmonary embolism of lung	1.69E-01	 	 	 	 	F2RL3	1	
Cardiac Regeneration	regeneration	regeneration of cardiomyocytes	1.69E-01	 	 	 	 	MTPN	1	
Cardiac Damage	reperfusion injury	reperfusion injury of myocardium	1.69E-01	 	 	 	 	ADIPOQ	1	
Liver Inflammation/Hepatitis	alcoholic hepatitis	severe alcoholic hepatitis	1.69E-01	 	 	 	 	TNFRSF1A	1	
Cardiac Arteriopathy	stable coronary artery disease	stable coronary artery disease	1.69E-01	 	 	 	 	P2RY12	1	
Cardiac Arteriopathy	stenosis	stenosis of coronary artery	1.69E-01	 	 	 	 	SGCD	1	
Cardiac Arteriopathy	susceptibility to severe coronary artery disease	susceptibility to severe coronary artery disease	1.69E-01	 	 	 	 	APOE	1	
Liver Cholestasis	transient idiopathic neonatal cholestasis	transient idiopathic neonatal cholestasis	1.69E-01	 	 	 	 	ABCB11	1	
Cardiac Arrythmia	variation QT syndrome	variation QT syndrome	1.69E-01	 	 	 	 	NHLH1	1	
Glomerular Injury, Renal Necrosis/Cell Death	necrosis	necrosis of renal glomerulus	1.72E-01	 	-0.378	 	-0.522	APOE,GFPT1,CTGF,CCNI,DUSP1,PLAU,PLAT	7	
Cardiac Hypertrophy	hypertrophy	hypertrophy of right ventricle	1.75E-01	 	-1.067	bias	-0.256	APOE,PDGFA,GAA,CXCL12	4	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	nonalcoholic steatohepatitis	1.75E-01	 	 	 	 	LEP,APOB,TNFRSF1A,ADIPOQ	4	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cells	1.79E-01	 	-0.429	 	-0.613	APOE,GFPT1,CTGF,DDIT3,CCNI,GLIS2,DUSP1,CSF1,UNC5B,SFRP1,HIF1A	11	
Liver Failure	acute liver failure	acute liver failure	1.86E-01	 	 	 	 	SLC7A11,GSS	2	
Liver Inflammation/Hepatitis	fulminant hepatitis	fulminant hepatitis	1.86E-01	 	 	 	 	BCL2L1,FAS	2	
Increased Levels of Potassium	quantity	increased quantity of K+	1.86E-01	 	 	 	 	STK39,HSD11B2	2	
Cardiac Stenosis	non-rheumatic aortic stenosis	non-rheumatic aortic stenosis	1.86E-01	 	 	 	 	VCAM1,MMP9	2	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of renal glomerulus	1.86E-01	 	 	 	 	APOE,C1QA	2	
Renal Hydronephrosis	hydronephrosis	hydronephrosis	1.88E-01	 	-1.452	bias	 	LGMN,SFRP2,LEP,TGFB2,ALCAM,PSAP,LZTS2,GPC3,APRT,ADRA1A,MMP9	11	
Renal Damage	damage	damage of kidney	1.88E-01	 	-0.494	 	-1.096	APOE,LEP,FCGR2A,SLC6A6,UNC5B,C1QA,FAS,CSF1,SREBF1,DUSP1,THBS1,ARHGDIA,ANXA7,MAP2K3,C3AR1,PLAT	16	
Cardiac Inflammation	inflammation	inflammation of heart	1.90E-01	 	-0.557	bias	0.287	TRAF3,TNFRSF1A,MAP3K1,PNKD,PPIA,CSF1R	6	
Renal Inflammation, Renal Nephritis	autoimmune glomerulonephritis	autoimmune glomerulonephritis	1.90E-01	 	 	 	 	PSMB5,DDIT3,IMPDH2,PSMD2,BMF,DGAT2,FKBP1A,ASNS	8	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	incidence	incidence of hepatocellular carcinoma	1.97E-01	 	-1.664	bias	 	HTATIP2,LEP,PRDX1,ENTPD5,HRAS,ANXA7,SOD1	7	
Cardiac Necrosis/Cell Death	cell death	cell death of ventricular myocytes	2.09E-01	 	0.098	 	0.339	S100A1,ADIPOQ,RTN4,HSPB6,ADRA1A	5	
Nephrosis	familial nephrotic syndrome	familial nephrotic syndrome	2.09E-01	 	 	 	 	PLCE1,IMPDH2,ARHGDIA	3	
Liver Necrosis/Cell Death	focal necrosis	focal necrosis of liver	2.09E-01	 	 	 	 	APOE,TYROBP,TNFRSF1A	3	
Pulmonary Hypertension	primary pulmonary hypertension	primary pulmonary hypertension	2.09E-01	 	 	 	 	BCL2L1,FHL1,P2RY12	3	
Cardiac Damage	damage	damage of cardiac muscle	2.12E-01	 	-0.594	bias	0.099	GDF15,ADIPOQ,TXN,SGCD	4	
Renal Atrophy	atrophy of kidney	atrophy of kidney	2.18E-01	Decreased	-2.165	bias	 	LGMN,EDNRB,GLIS2,GPC3,APRT,CD151	6	
Cardiac Damage	cardiovascular toxicity	cardiovascular toxicity	2.19E-01	 	 	 	 	ABCC1,CYBB	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	inoperable hepatocellular carcinoma	2.19E-01	 	 	 	 	KIT,RET	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	local hepatocellular carcinoma	2.19E-01	 	 	 	 	KIT,RET	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	unresectable hepatocellular carcinoma	2.19E-01	 	 	 	 	KIT,RET	2	
Cardiac Hypoplasia	hypoplasia	hypoplasia of trabeculae carne	2.25E-01	 	-1.400	bias	 	CALR,SHC1,MECOM,TGFB2,ITGAV	5	
Renal Inflammation, Renal Nephritis	interstitial nephritis	interstitial nephritis	2.33E-01	 	 	 	 	ARHGDIA,TNS1,CD151	3	
Liver Enlargement, Liver Hepatomegaly	hepatomegaly	hepatomegaly	2.38E-01	 	 	 	 	LIPA,CTSA,GBA,ENTPD5,ADIPOQ,EGLN3,ABCB11,NR1H3,IRF8,ESR2	10	
Cardiac Hypertrophy	hypertrophy	hypertrophy of left ventricle	2.38E-01	 	-0.378	bias	0.761	LEP,ADRA2A,GAA,PLIN5,FKBP1A,PLAU,HMGA1,ESR2,ADRA1A,PLAT	10	
Renal Necrosis/Cell Death	cell death	cell death of renal tubule	2.38E-01	Decreased	-2.184	 	-1.593	HMOX1,SPP1,GLIS2,THBS1,CSF1,UNC5B,HIF1A,APRT	8	
Liver Cirrhosis	cirrhosis	advanced stage cirrhosis	2.42E-01	 	 	 	 	F5	1	
Liver Cirrhosis	alcoholic cirrhosis	alcoholic cirrhosis	2.42E-01	 	 	 	 	MMP9	1	
Liver Steatosis	alcoholic fatty liver disease	alcoholic fatty liver disease	2.42E-01	 	 	 	 	ADIPOQ	1	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of cardiac stem cells	2.42E-01	 	 	 	 	SFRP2	1	
Nephrosis	autosomal recessive steroid-resistant nephrotic syndrome	autosomal recessive steroid-resistant nephrotic syndrome	2.42E-01	 	 	 	 	IMPDH2	1	
Liver Damage	histopathological change	histopathological change of liver	2.42E-01	 	 	 	 	APP	1	
Congenital Heart Anomaly	hypoplasia	hypoplasia of aortic arch	2.42E-01	 	 	 	 	TGFB2	1	
Glomerular Injury, Renal Hypoplasia	hypoplasia	hypoplasia of mesangial cells	2.42E-01	 	 	 	 	ARHGDIA	1	
Renal Inflammation, Renal Nephritis	idiopathic membranous nephropathy	idiopathic membranous nephropathy	2.42E-01	 	 	 	 	FKBP1A	1	
Pulmonary Hypertension	chronic thromboembolic pulmonary hypertension	inoperable chronic thromboembolic pulmonary hypertension	2.42E-01	 	 	 	 	P2RY12	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	metastasis	metastasis of hepatocellular carcinoma	2.42E-01	 	 	 	 	TNFAIP8L2	1	
Liver Cholestasis	obstruction	obstruction of bile duct	2.42E-01	 	 	 	 	GJB2	1	
Cardiac Stress Response	oxidative stress response	oxidative stress response of myocardium	2.42E-01	 	 	 	 	TXN	1	
Pulmonary Hypertension	persistent fetal circulation syndrome	persistent fetal circulation syndrome	2.42E-01	 	 	 	 	EDNRB	1	
Liver Proliferation	proliferation	proliferation of liver	2.42E-01	 	 	 	 	CEBPB	1	
Glutathione Depletion In Liver, Liver Fibrosis	quantity	quantity of reactive oxygen species in liver	2.42E-01	 	 	 	 	CERS2	1	
Cardiac Infarction	myocardial infarction	recurrent myocardial infarction	2.42E-01	 	 	 	 	VKORC1	1	
Cardiac Damage	rupture	rupture of myocardium	2.42E-01	 	 	 	 	GDF15	1	
Liver Damage, Liver Inflammation/Hepatitis	susceptibility to hepatitis C virus	susceptibility to hepatitis C virus	2.42E-01	 	 	 	 	PTPRC	1	
Cardiac Damage	damage	damage of myocardium	2.53E-01	 	 	 	 	GDF15,ADIPOQ	2	
Renal Atrophy	atrophy	atrophy of renal tubule	2.58E-01	 	 	 	 	LGMN,GLIS2,APRT	3	
Glutathione Depletion In Liver	conjugation	conjugation of glutathione	2.58E-01	 	 	 	 	GSTM5,CYP1B1,GSTP1	3	
Glomerular Injury, Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of mesangial cells	2.58E-01	 	 	 	 	CEBPB,PKN1,CD151	3	
Liver Hyperplasia/Hyperproliferation	incidence	incidence of liver tumor	2.63E-01	 	-1.912	bias	 	HTATIP2,LEP,SRPX,PRDX1,ENTPD5,HRAS,ANXA7,SOD1	8	
Increased Levels of Creatinine	quantity	increased quantity of creatinine	2.77E-01	 	 	 	 	SLC4A5,CTGF,ST6GALNAC2,HSD11B2,AKR1B1	5	
Heart Failure	failure	failure of heart	2.77E-01	 	0.633	bias	2.357	GAB2,SLC7A11,CTGF,KCND3,DUSP6,CA5B,ADIPOQ,CA12,FKBP1A,GSS,SLC9A1,CAMK2D,PARK7,STAB1,PPIF,MAP3K1,RAPGEF3,DES,BCL2L1,MTPN,PPP2R1A,CAPNS1,ADRA2A,LIMS1,P2RY12,SOX9,PLAU,PPP2R1B,MMP9,ADRA1A	30	
Renal Necrosis/Cell Death	necrosis	necrosis of renal tubule	2.78E-01	 	-1.947	 	-1.336	HMOX1,SPP1,GLIS2,CSF1,UNC5B,HIF1A,APRT	7	
Cardiac Stenosis	stenosis	stenosis of semilunar valve	2.78E-01	 	 	 	 	VCAM1,PLCE1,SPP1,APOB,NTRK3,MMP9	6	
Liver Hyperbilirubinemia	hyperbilirubinemia	hyperbilirubinemia	2.82E-01	 	 	 	 	FCGR2A,ABCC3,GSTP1	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	metastatic hepatocellular carcinoma	metastatic hepatocellular carcinoma	2.87E-01	 	 	 	 	KIT,RET	2	
Cardiac Arrythmia	tachyarrhythmia	tachyarrhythmia	2.87E-01	 	 	 	 	ADRA2A,ADRA1A	2	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of ventricular myocytes	2.92E-01	 	0.747	 	0.850	S100A1,ADIPOQ,RTN4,ADRA1A	4	
Congenital Heart Anomaly	failure of heart looping	failure of heart looping	2.92E-01	 	-0.655	bias	 	ALDH1A2,TGFB2,NCSTN,GNG5	4	
Cardiac Damage	injury	injury of heart	2.94E-01	 	-0.278	 	0.187	ANXA1,ADIPOQ,ATF4,MAP2K3,TXN	5	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis	chronic hepatitis	3.06E-01	 	 	 	 	SPP1,LEP,IMPDH2,ADIPOQ,LGALS9,FKBP1A,GABBR1,POR,PTPRC,BCL2L1,CSF1,GAA,STAB1,MMP9	14	
Liver Inflammation/Hepatitis	viral hepatitis	viral hepatitis	3.06E-01	 	 	 	 	LEP,SPP1,FCGR2A,IMPDH2,ADIPOQ,LGALS9,GABBR1,FKBP1A,PTPRC,POR,BCL2L1,CSF1,GAA,MMP9	14	
Liver Fibrosis	migration	migration of hepatic stellate cells	3.07E-01	 	 	 	 	CTGF,SPP1,RACK1	3	
Biliary Hyperplasia	bile duct proliferation	bile duct proliferation	3.09E-01	 	 	 	 	CFTR	1	
Liver Hyperplasia/Hyperproliferation	liver cancer	early stage liver cancer	3.09E-01	 	 	 	 	FOS	1	
Cardiac Inflammation	endocarditis	endocarditis	3.09E-01	 	 	 	 	ITGB2	1	
Liver Inflammation/Hepatitis	hepatitis A	hepatitis A	3.09E-01	 	 	 	 	CSF1	1	
Renal Hypoplasia	hypoplasia	hypoplasia of renal cortex	3.09E-01	 	 	 	 	MMP14	1	
Decreased Levels of Potassium	uptake	increased uptake of K+	3.09E-01	 	 	 	 	FAS	1	
Liver Damage	injury	injury of hepatocytes	3.09E-01	 	 	 	 	EGR1	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome 1	long QT syndrome 1	3.09E-01	 	 	 	 	CALM1 (includes others)	1	
Renal Inflammation, Renal Nephritis	lupus-like autoimmune nephritis	lupus-like autoimmune nephritis	3.09E-01	 	 	 	 	NFE2L2	1	
Kidney Failure	nephrotoxic acute renal failure	nephrotoxic acute renal failure	3.09E-01	 	 	 	 	HMOX1	1	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	progressive crescentic glomerulonephritis	3.09E-01	 	 	 	 	VCAM1	1	
Liver Cholestasis	secretion	secretion of bile salt	3.09E-01	 	 	 	 	ABCB11	1	
Heart Failure	heart failure	severe heart failure	3.09E-01	 	 	 	 	CAMK2D	1	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubule	3.10E-01	 	-1.673	 	-1.280	HMOX1,GLIS2,THBS1,CSF1,UNC5B,HIF1A	6	
Renal Dilation	dilation	dilation of renal tubule	3.21E-01	 	 	 	 	ARHGDIA,APRT	2	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal glomerulus	3.26E-01	 	-0.816	 	-0.915	APOE,GFPT1,CTGF,CCNI,DUSP1,C1QA	6	
Liver Inflammation/Hepatitis	alcoholic hepatitis	alcoholic hepatitis	3.33E-01	 	 	 	 	TNFRSF1A,ABCB11,FAS,GSTP1	4	
Renal Hypoplasia	hypoplasia	hypoplasia of kidney	3.42E-01	 	-0.520	bias	 	MMP14,BAG6,ALDH1A2,ITGA8,ARHGDIA,RET	6	
Kidney Failure	chronic renal failure	chronic renal failure	3.42E-01	Decreased	-2.157	bias	 	SLC7A11,APOB,SGCG,TNFRSF1A,IMPDH2,FCGR2A,MMP14,ADIPOQ,FKBP1A,GSS,APRT,LGMN,PHB,GLIS2,P2RY12,TFPI,CD151	17	
Congenital Heart Anomaly	persistent truncus arteriosus	persistent truncus arteriosus	3.54E-01	 	-1.951	bias	 	FLNA,DVL1,DVL3,PLXND1	4	
Liver Proliferation	proliferation	proliferation of oval cells	3.55E-01	 	 	 	 	CXCL12,TNFRSF12A	2	
Renal Inflammation, Renal Nephritis	nephritis	Nephritis	3.56E-01	Decreased	-2.396	bias	-0.566	TRAF3,LEP,DDIT3,FKBP1A,C1QA,HIF1A,ASNS,APRT,FAS,PTPRC,CD28,SLC19A3,HMOX1,TOP2A,MAPKAPK2,NFE2L2,VCAM1,PSMB5,SPP1,TP63,TNFRSF1A,IMPDH2,FCGR2A,DGAT2,CEBPB,PKN1,CXCL16,EFS,GLIS2,CSF1,IL1RN,PSMD2,BMF,ARHGDIA,TNS1,MMP9,CD151	37	
Congenital Heart Anomaly	congenital heart disease	congenital heart disease	3.59E-01	 	-1.880	bias	 	ADAM17,FCGR2A,TXNL4A,DVL1,CXCL12,FKBP1A,NCSTN,THRA,NAA10,GPC3,PLXND1,CALM1 (includes others),PLCE1,ADRA2A,NTRK3,FLNA,ALDH1A2,TGFB2,P2RY12,DVL3,B3GAT3,GNG5,MGAT1,MEGF8	24	
Liver Steatosis	nonalcoholic fatty liver disease	nonalcoholic fatty liver disease	3.66E-01	 	 	 	 	LEP,UCP2,SREBF1,PLIN2,ADIPOQ,SOD1,CYP4A11	7	
Congenital Heart Anomaly	atrial septal defect	atrial septal defect	3.66E-01	 	-1.067	bias	 	ADRA2A,FLNA,TGFB2,GPC3,MEGF8	5	
Liver Damage, Liver Inflammation/Hepatitis	acute hepatitis C	acute hepatitis C	3.70E-01	 	 	 	 	CSF1	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of oval cells	3.70E-01	 	 	 	 	BMF	1	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction of left ventricle	3.70E-01	 	 	 	 	CYBB	1	
Cardiac Enlargement	enlargement	enlargement of atrium	3.70E-01	 	 	 	 	GSK3B	1	
Cardiac Arrythmia	idiopathic ventricular fibrillation	idiopathic ventricular fibrillation	3.70E-01	 	 	 	 	DSP	1	
Decreased Levels of Albumin	uptake	increased uptake of albumin	3.70E-01	 	 	 	 	FLNA	1	
Cardiac Damage, Cardiac Degeneration	injury	injury of cardiomyocytes	3.70E-01	 	 	 	 	TXN	1	
Renal Necrosis/Cell Death	survival	survival of mesangial cells	3.70E-01	 	 	 	 	FAS	1	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of glomerular capillary	3.70E-01	 	 	 	 	APOE	1	
Renal Proliferation	proliferation	proliferation of kidney cells	3.71E-01	 	0.216	 	-0.128	APOE,DUSP1,CSF1,MMP14,BAG6,FCER1G,PLAU,AKR1B1	8	
Renal Inflammation, Renal Nephritis	IgA nephropathy	IgA nephropathy	3.75E-01	 	 	 	 	PSMB5,IMPDH2,PSMD2,DGAT2	4	
Heart Failure	chronic heart failure	chronic heart failure	3.75E-01	 	 	 	 	ADRA2A,CA5B,CA12,ADRA1A	4	
Kidney Failure	end stage renal disease	end stage renal disease	3.75E-01	Decreased	-2.157	bias	 	SLC7A11,SGCG,TNFRSF1A,IMPDH2,FCGR2A,MMP14,ADIPOQ,FKBP1A,GSS,APRT,LGMN,GLIS2,PHB,CD151	14	
Congenital Heart Anomaly	perimembranous ventricular septal defect	perimembranous ventricular septal defect	3.82E-01	 	 	 	 	TGFB2,CXCL12,GPC3	3	
Heart Failure	cardiac decompensation	cardiac decompensation	3.88E-01	 	 	 	 	DUSP6,ADRA1A	2	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of mesangial cells	3.88E-01	 	 	 	 	PARK7,NUPR1	2	
Renal Necrosis/Cell Death	survival	survival of glomerular cells	3.88E-01	 	 	 	 	CCNI,FAS	2	
Liver Fibrosis	activation	activation of hepatic stellate cells	4.03E-01	 	1.204	bias	0.178	LEP,CXCL12,PLAU,NDN,MMP9	5	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of glomerular cells	4.03E-01	 	-0.447	 	-0.752	APOE,GFPT1,CTGF,CCNI,DUSP1	5	
Cardiac Stenosis	stenosis	stenosis of aortic valve	4.03E-01	 	 	 	 	VCAM1,PLCE1,SPP1,APOB,MMP9	5	
Liver Adhesion	adhesion	adhesion of hepatocytes	4.26E-01	 	 	 	 	VCAM1	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic autoimmune hepatitis	chronic autoimmune hepatitis	4.26E-01	 	 	 	 	PTPRC	1	
Decreased Levels of Albumin	activation	decreased activation of albumin	4.26E-01	 	 	 	 	UBE2I	1	
Renal Dilation	dilation	dilation of collecting tubule	4.26E-01	 	 	 	 	ARHGDIA	1	
Liver Fibrosis	experimentally-induced hepatic fibrosis	experimentally-induced hepatic fibrosis	4.26E-01	 	 	 	 	SPP1	1	
Biliary Hyperplasia, Liver Cholestasis	flow	flow of bile	4.26E-01	 	 	 	 	ABCB11	1	
Increased Levels of ALT	release	increased release of ALT	4.26E-01	 	 	 	 	SPP1	1	
Liver Cholestasis	progressive familial intrahepatic cholestasis type 2	progressive familial intrahepatic cholestasis type 2	4.26E-01	 	 	 	 	ABCB11	1	
Cardiac Inflammation	rheumatic carditis	rheumatic carditis	4.26E-01	 	 	 	 	ANXA1	1	
Liver Steatosis	hepatic steatosis	severe hepatic steatosis	4.26E-01	 	 	 	 	UCP2	1	
Cardiac Stenosis	stenosis	stenosis of pulmonary valve	4.26E-01	 	 	 	 	NTRK3	1	
Cardiac Arrythmia	ventricular extrasystole	ventricular extrasystole	4.26E-01	 	 	 	 	NHLH1	1	
Liver Necrosis/Cell Death	cell death	cell death of liver cell lines	4.36E-01	 	-0.105	 	-0.425	BCL2L1,LAMP2,DUSP4,FAS	4	
Nephrosis	minimal change nephrotic syndrome	minimal change nephrotic syndrome	4.51E-01	 	 	 	 	IMPDH2,FKBP1A	2	
Liver Damage, Liver Inflammation/Hepatitis	chronic viral hepatitis	chronic viral hepatitis	4.51E-01	 	 	 	 	POR,BCL2L1,LEP,SPP1,IMPDH2,CSF1,GAA,ADIPOQ,LGALS9,MMP9	10	
Renal Necrosis/Cell Death	apoptosis	apoptosis of tubular cells	4.56E-01	 	-1.091	 	-0.837	GLIS2,CSF1,UNC5B,HIF1A	4	
Kidney Failure	acute tubular necrosis	acute tubular necrosis	4.77E-01	 	 	 	 	SPP1	1	
Congenital Heart Anomaly	bicuspid aortic valve	bicuspid aortic valve	4.77E-01	 	 	 	 	PLCE1	1	
Cardiac Enlargement	enlargement	enlargement of cardiomyocytes	4.77E-01	 	 	 	 	KLF4	1	
Increased Levels of Bilirubin	quantity	increased quantity of bilirubin	4.77E-01	 	 	 	 	LEP	1	
Cardiac Infarction	non-ST elevation myocardial infarction	non-ST elevation myocardial infarction	4.77E-01	 	 	 	 	P2RY12	1	
Renal Proliferation	proliferation	proliferation of podocytes	4.77E-01	 	 	 	 	DUSP1	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	quantity	quantity of hepatocellular carcinoma	4.77E-01	 	 	 	 	LEP	1	
Liver Damage	reperfusion injury	reperfusion injury of liver	4.77E-01	 	 	 	 	HMOX1	1	
Congenital Heart Anomaly	heart septal defect	heart septal defect	4.85E-01	 	-1.318	bias	 	ADAM17,ADRA2A,NTRK3,FLNA,DVL1,TGFB2,CXCL12,FKBP1A,DVL3,GPC3,MEGF8	11	
Cardiac Congestive Cardiac Failure, Heart Failure	congestive heart failure	congestive heart failure	4.88E-01	 	-0.816	bias	 	SLC7A11,ADRA2A,MAP3K1,ADIPOQ,FKBP1A,STAB1,SOX9,DES,GSS,ADRA1A	10	
Renal Damage	reperfusion injury	reperfusion injury of kidney	5.02E-01	 	 	 	 	THBS1,UNC5B,C3AR1	3	
Liver Hematopoiesis	hematopoiesis	hematopoiesis of liver	5.10E-01	 	 	 	 	FOS,SOCS3	2	
Congenital Heart Anomaly	transposition	transposition of great vessels	5.10E-01	 	 	 	 	DVL1,DVL3	2	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	acute phase crescentic glomerulonephritis	5.23E-01	 	 	 	 	VCAM1	1	
Decreased Levels of Hematocrit	hematocrit	decreased hematocrit of organism	5.23E-01	 	 	 	 	EGLN3	1	
Cardiac Arteriopathy	premature coronary artery disease	early-onset premature coronary artery disease	5.23E-01	 	 	 	 	LRP8	1	
Renal Inflammation, Renal Nephritis	nephrotoxic nephritis	nephrotoxic nephritis	5.23E-01	 	 	 	 	LEP	1	
Cardiac Fibrosis	perivascular fibrosis	perivascular fibrosis	5.23E-01	 	 	 	 	HMOX1	1	
Congenital Heart Anomaly	ventricular septal defect	ventricular septal defect	5.23E-01	 	-1.208	bias	 	ADAM17,NTRK3,FLNA,DVL1,TGFB2,CXCL12,FKBP1A,DVL3,GPC3,MEGF8	10	
Liver Hemorrhaging	bleeding	bleeding of liver	5.25E-01	 	 	 	 	IL1RN,FKBP1A,FAS	3	
Liver Hyperplasia/Hyperproliferation	metastasis	metastasis of liver	5.26E-01	 	 	 	 	KIT,FGFR2,PLAU,RET,PRNP	5	
Renal Proliferation	proliferation	proliferation of glomerular cells	5.26E-01	 	-0.130	 	-0.574	APOE,DUSP1,FCER1G,PLAU,AKR1B1	5	
Congenital Heart Anomaly	familial congenital heart disease	familial congenital heart disease	5.35E-01	 	-1.348	bias	 	PLCE1,FLNA,TXNL4A,DVL1,TGFB2,DVL3,B3GAT3,NAA10,GPC3,PLXND1	10	
Liver Degeneration	degeneration	degeneration of liver	5.47E-01	 	 	 	 	PHYH,NR1H3,GSK3B	3	
Liver Hyperplasia/Hyperproliferation	liver adenoma	liver adenoma	5.47E-01	 	 	 	 	ENTPD5,GLUL,CYP1B1	3	
Renal Proliferation	proliferation	proliferation of mesangial cells	5.53E-01	 	 	 	 	APOE,FCER1G,PLAU,AKR1B1	4	
Heart Failure	cardiac death	cardiac death	5.65E-01	 	 	 	 	P2RY12	1	
Renal Dilation	dilation	dilation of kidney	5.65E-01	 	 	 	 	EDNRB	1	
Cardiac Enlargement	enlargement	enlargement of heart	5.65E-01	 	 	 	 	NDUFS6	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	growth	growth of hepatocellular carcinoma	5.65E-01	 	 	 	 	PROX1,GPC3	2	
Renal Inflammation, Renal Nephritis	membranous glomerulonephritis	membranous glomerulonephritis	5.65E-01	 	 	 	 	IMPDH2,FKBP1A	2	
Bradycardia, Cardiac Arrythmia	sinus bradycardia	sinus bradycardia	5.65E-01	 	 	 	 	CALR	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	size	size of hepatocellular carcinoma	5.65E-01	 	 	 	 	LEP	1	
Cardiac Arrythmia	long-QT syndrome	long-QT syndrome	5.68E-01	 	 	 	 	SLC2A5,CALM1 (includes others),TMEM43	3	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubular epithelial cells	5.91E-01	 	 	 	 	GLIS2,UNC5B	2	
Congenital Heart Anomaly	atrioventricular septal defect and common atrioventricular junction	atrioventricular septal defect and common atrioventricular junction	5.91E-01	 	 	 	 	TGFB2,GPC3	2	
Renal Necrosis/Cell Death	apoptosis	apoptosis of proximal tubule cells	6.04E-01	 	 	 	 	HIF1A	1	
Glomerular Injury, Renal Atrophy	atrophy	atrophy of renal glomerulus	6.04E-01	 	 	 	 	GLIS2	1	
Renal Atrophy	atrophy	atrophy of renal medulla	6.04E-01	 	 	 	 	APRT	1	
Cardiac Dysfunction, Heart Failure	diastolic heart failure	diastolic heart failure	6.04E-01	 	 	 	 	CTGF	1	
Liver Hematopoiesis	erythropoiesis	erythropoiesis of liver	6.04E-01	 	 	 	 	FOS	1	
Hepatocellular Peroxisome Proliferation	formation	formation of peroxisomes	6.04E-01	 	 	 	 	PEX10	1	
Liver Hyperplasia/Hyperproliferation	hepatic adenocarcinoma	hepatic adenocarcinoma	6.04E-01	 	 	 	 	THBS1	1	
Kidney Failure	ischemic acute renal failure	ischemic acute renal failure	6.04E-01	 	 	 	 	HMOX1	1	
Renal Necrosis/Cell Death	survival	survival of podocytes	6.04E-01	 	 	 	 	CCNI	1	
Congenital Heart Anomaly	congenital heart block	congenital heart block	6.39E-01	 	 	 	 	FCGR2A	1	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal glomerulus	6.39E-01	 	 	 	 	STAB1	1	
Cardiac Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of heart	6.39E-01	 	 	 	 	DUSP6	1	
Cardiac Hypertrophy	hypertrophy	hypertrophy of myocardium	6.39E-01	 	 	 	 	MTPN	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cell lines	1.00E00	 	 	 	 	DUSP4,FAS	2	
Cardiac Arrythmia	arrhythmia	arrhythmia of heart ventricle	1.00E00	 	 	 	 	CALM1 (includes others),ADRA2A,ANXA7,THRA,NHLH1,DSP,ADRA1A	7	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 1	catecholaminergic polymorphic ventricular tachycardia type 1	1.00E00	 	 	 	 	CALM1 (includes others)	1	
Congenital Heart Anomaly	conotruncal heart malformations	conotruncal heart malformations	1.00E00	 	-1.953	bias	 	FLNA,DVL1,TGFB2,DVL3,GPC3,PLXND1	6	
Renal Damage, Renal Tubule Injury	damage	damage of renal tubule	1.00E00	 	 	 	 	APOE,THBS1,CSF1	3	
Renal Inflammation, Renal Nephritis	glomerulonephritis	glomerulonephritis	1.00E00	Decreased	-2.728	bias	-1.615	VCAM1,PSMB5,SPP1,DDIT3,TNFRSF1A,FCGR2A,IMPDH2,DGAT2,FKBP1A,C1QA,CEBPB,ASNS,FAS,PKN1,PTPRC,HMOX1,CD28,CXCL16,GLIS2,IL1RN,BMF,PSMD2,MAPKAPK2,NFE2L2,MMP9	25	
Increased Levels of Alkaline Phosphatase	activation	increased activation of alkaline phosphatase	1.00E00	 	 	 	 	CTGF,LEP,MAP3K1,BMP6	4	
Renal Inflammation, Renal Nephritis	lupus nephritis	lupus nephritis	1.00E00	 	 	 	 	PTPRC,CXCL16,VCAM1,PSMB5,TNFRSF1A,FCGR2A,IMPDH2,PSMD2,FKBP1A,FAS	10	
Cardiac Arrythmia, Tachycardia	ventricular tachycardia	ventricular tachycardia	1.00E00	 	 	 	 	CALM1 (includes others),ADRA2A,ANXA7,THRA,ADRA1A	5	

Regulator Effects for My Projects->David Bulger->P3
Consistency Score	Node Total	Regulator Total	Regulators	Target Total	Target Molecules in Dataset	Disease & Function Total	Diseases & Functions	Known Regulator-Disease/Function Relationships
17.558	27	2	SNAI2,SPP1	15	ADIPOQ,BCL2L1,BSG,CAPNS1,CDC42,CXCL12,FGFR2,FOS,HMOX1,ITGAV,MMP14,MMP9,PDGFA,PLAU,TP63	9	adhesion of connective tissue cells,binding of cells,cell movement of connective tissue cells,cell movement of tumor cells,cell spreading,formation of lamellipodia,migration of breast cancer cell lines,proliferation of tumor cells,transmigration of cells	67% (12/18)	
17.473	22	4	AGT,ATF4,EIF4E,LDL	13	APOE,CALR,CAPG,CEBPB,DAB2,HMOX1,HYOU1,MSR1,PFN1,PLAU,PTX3,RHOG,UCP2	5	engulfment of antigen presenting cells,engulfment of myeloid cells,engulfment of phagocytes,engulfment of tumor cell lines,phagocytosis of leukocytes	5% (1/20)	
16.583	20	3	ACACB,MAP4K4,p70 S6k	11	CCND3,CEBPB,EEF1A1,GOT1,GYS1,LEP,MVD,PHYH,SCD,SREBF1,SREBF2	6	concentration of lipid,conversion of lipid,mass of adipose tissue,metabolism of carbohydrate,quantity of connective tissue,synthesis of lipid	22% (4/18)	
13.481	53	9	BRD4,CHUK,GAST,IKBKB,IKBKG,PGR,SPP1,STAT4,TNFSF11	37	ADIPOQ,BCL2L1,BSG,CAPN2,CD4,CSF1,CSF1R,CTSB,CTSD,CXCL12,CYP1B1,DAB2,FGFR2,FSCN1,FYB,GRN,HIF1A,IL1RN,ITGAV,MAP2K3,MAP3K1,MARCKSL1,MMP14,MMP9,MTHFD1L,MTMR2,NAGLU,NDUFS4,NR1H3,PDGFA,PLAU,POR,SDC4,SLC4A2,SLC9A1,SMARCA4,VCAM1	7	cell movement of endothelial cells,cell spreading,degeneration of neurons,exencephaly,formation of lamellipodia,fusion of cells,neurodegeneration of brain	10% (6/63)	
11.132	51	8	JUN,mir-10,MYC,MYCN,NFE2L2,PGR,PML,RICTOR	43	APP,CYCS,CYGB,EEF1A1,EIF3G,FAU,HSPA9,NQO1,PNO1,PRDX1,PSMA3,PSMA4,PSMA5,PSMB5,PSMC4,RAN,RPL13,RPL13A,RPL19,RPL31,RPL35,RPL37,RPL37A,RPL38,RPL7A,RPL9,RPLP0,RPS11,RPS12,RPS13,RPS16,RPS19,RPS21,RPS24,RPS29,RPS3,RPS4Y1,RPS5,SNRPD1,SOD1,TXN,UBE2I,VDAC2	2	cell death of osteosarcoma cells,modification of reactive oxygen species	0% (0/16)	
10.436	52	4	GAST,IL5,mir-15,TAS1R3	40	ANXA2,APP,ATF4,BCL2L1,CARM1,CCND2,CCND3,CD63,CDC42,CDK6,CHMP1A,CISD1,EGR1,FAS,FGF1,FOS,HIF1A,HMGA1,HSPA5,HSPH1,IMPDH2,ITGAV,LFNG,MAT2A,MMP9,ODC1,PAX5,PDIA6,PHB,PKM,POR,RPS19,SLC16A1,SLC3A2,SLC4A2,SLC7A11,SLC7A5,STK39,UCP2,VCAM1	8	activation of cells,cell proliferation of breast cancer cell lines,cell transformation,generation of cells,growth of tumor,proliferation of liver cells,proliferation of muscle cells,Viral Infection	38% (12/32)	
10.328	23	5	EGR1,IKBKB,IKBKG,INSR,miR-16-5p (and other miRNAs w/seed AGCAGCA)	15	ACP2,BCL2L1,CSF1,CTSB,FTL,GAPDH,GRN,HIF1A,IL1RN,NAGLU,NFE2L2,NR1H3,SOD1,SQSTM1,THRA	3	degeneration of nervous system,gliosis,Neurodegeneration	0% (0/15)	
10.205	14	1	mir-15	7	APP,CCND2,CDC42,CDK6,FGF1,HMGA1,MMP9	6	cell movement of tumor cell lines,cell proliferation of tumor cell lines,cell transformation,formation of filaments,metabolism of membrane lipid derivative,secretion of molecule	33% (2/6)	
9.602	30	3	let-7a-5p (and other miRNAs w/seed GAGGUAG),mir-15,NR1I2	21	APP,BCL2L1,BSG,CCND2,CDC42,CDK6,ENTPD5,FGF1,GOT1,GSTP1,GYS1,HMGA1,HMOX1,HRAS,MMP9,PGD,POR,RHOG,SCD,SLC25A13,SREBF1	6	cell transformation,colony formation of cells,formation of actin filaments,inflammation of liver,size of body,synthesis of carbohydrate	6% (1/18)	
9.250	23	3	ARNT2,NFYA,SIM1	16	AKR1B1,APOE,CALR,CDC42,EGR1,EPHX1,FCGR2A,FGFR2,HLA-A,HSPA5,LEP,LTF,MLH1,PKM,PLP1,SCD	4	fatty acid metabolism,quantity of metal ion,replication of virus,synthesis of carbohydrate	0% (0/12)	
9.070	112	12	ALDH2,ARHGDIG,ARNT,BACH1,DDIT3,EIF4E,GAST,NRF1,PIK3R1,PLIN5,THBS4,YY1	92	ADAM17,ALAS1,ALCAM,ALDOA,ANXA1,ANXA7,ATF4,ATOX1,ATP5G1,BCL2L1,BHLHE41,BMP6,BTG2,CALR,CAPG,CAPZB,CCND2,CEBPB,CFTR,COL5A2,COX7B,COX8A,CTSD,CXCL12,CYBB,CYCS,CYP1B1,DUSP6,EGR1,EIF4G2,EIF6,ENO1,FAS,FOS,FTH1,GAPDH,GBP1,GCLM,GPC3,GPS2,GSS,HIF1A,HMOX1,HRAS,HSPA5,HSPD1,HSPE1,HYOU1,ID4,IL1RN,ILF2,IMPDH2,ITGAV,KIF5B,LEP,LPAR1,MKI67,MMP9,NDUFS4,NFE2L1,NFE2L2,NQO1,PCK1,PDGFA,PHB,PKM,PLAU,POR,PRDX5,PSAT1,PVR,RHOG,RPS19,SHMT2,SIM1,SLC1A4,SLC3A2,SLC4A2,SLC7A5,SPP1,SQSTM1,SURF1,TFRC,TGFB2,TOP2A,TRIB3,TXNRD1,UBE2A,UNG,VCAM1,VDAC1,ZPR1	8	cell viability of tumor cell lines,disorder of basal ganglia,inflammation of liver,invasion of tumor cell lines,metabolism of nucleoside triphosphate,organismal death,phagocytosis,quantity of reactive oxygen species	16% (15/96)	
8.820	20	3	let-7a-5p (and other miRNAs w/seed GAGGUAG),miR-124-3p (and other miRNAs w/seed AAGGCAC),mir-15	14	APP,BCL2L1,BSG,CDC42,CDK6,EGR1,FGF1,HMGA1,HMOX1,HRAS,MMP9,RHOG,SLC25A13,SOX9	3	colony formation of cells,size of body,transformation of fibroblast cell lines	0% (0/9)	
8.660	17	3	CSF1,IKBKB,SPP1	12	CXCL12,FCGR2A,FGFR2,HIF1A,ITGAV,MMP14,MMP9,MSR1,PDGFA,PLAU,THBS1,VCAM1	2	cell spreading,migration of breast cancer cell lines	33% (2/6)	
8.538	16	4	CHUK,IKBKB,IKBKG,IL4	10	APOE,BCL2L1,CLCN3,CTSB,GRN,HIF1A,IL1RN,NAGLU,PRNP,STUB1	2	degeneration of neurons,neurodegeneration of brain	0% (0/8)	
8.273	36	14	AGT,APP,CEBPA,CEBPB,CSF1,EGF,EGR1,FOXO1,IL1,IL3,PI3K (complex),SPP1,TNFSF11,Vegf	20	ADAM17,CDC42,CSF1R,CTSS,CXCL12,ESR2,FCER1G,FOS,GAB2,GSK3B,ITGAV,ITGB2,MCAM,MMP14,MMP9,PVR,SIRPA,SLC4A2,TNFRSF1A,VCAM1	2	high bone mass disease,transmigration of monocytes	14% (4/28)	
8.262	23	3	BID,CUL4B,miR-204-5p (and other miRNAs w/seed UCCCUUU)	15	ADAM17,C3AR1,CDH11,CTSB,CTSD,CTSS,EFNB1,HSPA9,IGFBP3,MMP9,NME1,PYGO2,SHC1,SOD1,TPM3	5	immune response of cells,proliferation of cells,proteolysis,quantity of blood cells,Rheumatic Disease	33% (5/15)	
8.083	18	2	CCL5,miR-124-3p (and other miRNAs w/seed AAGGCAC)	12	CAPN2,CDK6,CERS2,CYP1B1,EGR1,ELOVL1,FOS,HMGA1,MMP9,RHOG,SOD1,SOX9	4	colony formation of cells,proliferation of smooth muscle cells,synthesis of lipid,transformation of fibroblast cell lines	25% (2/8)	
8.074	30	7	AGT,CD28,CSF2,IL2,let-7a-5p (and other miRNAs w/seed GAGGUAG),miR-124-3p (and other miRNAs w/seed AAGGCAC),SYVN1	21	ATP6AP1,BIN1,CCND3,CD209,CDK6,CSF1,CSF1R,CXCL12,EGR1,FGFR2,FOS,GSK3B,HMGA1,HRAS,ITGAV,ODC1,PDGFA,RHOG,SHC1,SOX9,TFRC	2	transformation of fibroblast cell lines,viral entry by virus	7% (1/14)	
8.000	11	6	CSF2,EGR1,IGF1,PI3K (complex),SP1,TGFB1	4	CTSD,LYZ,MMP14,MMP9	1	molecular cleavage of proteoglycan	0% (0/6)	
7.839	17	4	ANGPT2,ATF4,F2,PI3K (complex)	11	CALR,CEBPB,FAS,HDAC2,HMOX1,ITGB2,PLAU,PRKCE,PTX3,THBS1,VCAM1	2	engulfment by macrophages,response of phagocytes	13% (1/8)	
7.778	23	3	CFB,GAST,THBS4	18	ANXA7,ATF4,C3AR1,CALR,EGR1,FOS,HSPA5,HYOU1,IMPDH2,MMP9,NARS,PHB,POR,RPS19,SLC4A2,SREBF1,TGFB2,VCAM1	2	cell movement,organismal death	67% (4/6)	
7.500	22	2	SP1,SPP1	16	ADIPOQ,APOE,C1QBP,CD28,CTGF,CXCL12,FAS,FLNA,ITGAV,KIT,MMP14,MMP9,PDGFA,PLAU,PRKCE,TGFB2	3	cell movement of glioma cells,cell spreading,formation of lamellipodia	33% (2/6)	
7.333	14	2	PGR,SPP1	9	ADIPOQ,CAPN2,CXCL12,ITGAV,MMP9,PDGFA,PLAU,SLC7A5,SLC9A1	3	adhesion of connective tissue cells,binding of cells,cell spreading	67% (4/6)	
7.249	30	3	EIF4E,let-7a-5p (and other miRNAs w/seed GAGGUAG),mir-15	22	APP,BCL2L1,BSG,CAPG,CCND2,CDC42,CDK6,CEBPB,FGF1,HIF1A,HMGA1,HMOX1,HRAS,IGFBP4,MMP9,ODC1,PHB,RHOG,SLC25A13,THBS1,UBE2A,UCP2	5	cell transformation,engulfment by macrophages,invasion of cells,necrosis of tumor,size of body	27% (4/15)	
7.071	40	5	CD40LG,EGR1,IL1,IL3,IL5	32	ADAM17,ADAMTS5,ANXA2,APOE,APP,BTG2,CSF1,CSF1R,CTSB,EIF3G,FAS,FCGR2A,FOS,HLA-A,HSPA5,HSPA9,IMPDH2,ITGAV,ITGB2,MAT2A,MMP14,MMP9,NINJ1,PDIA6,PFKL,PSMA5,PSMC4,PVR,SLC4A2,STT3A,TFRC,VCAM1	3	high bone mass disease,infection by RNA virus,transmigration of phagocytes	27% (4/15)	
7.071	13	1	FGF10	8	ANXA1,ANXA2,CEBPB,CTSB,CYP1B1,LFNG,MMP14,SOX9	4	generation of cells,homing of cells,invasion of tumor cell lines,migration of tumor cell lines	100% (4/4)	
6.971	20	2	GAST,miR-124-3p (and other miRNAs w/seed AAGGCAC)	15	ATF4,BTG3,CDK6,CYP1B1,EGR1,FOS,MMP9,ODC1,PLOD3,RHOG,RPS19,SLC4A2,SOX9,UHMK1,VCAM1	3	generation of cells,proliferation of muscle cells,transformation of fibroblast cell lines	33% (2/6)	
6.881	31	4	CD40LG,HSF2,IL1,IL5	23	ADAM17,ADAMTS5,ANXA2,APOE,APP,CSF1,CSF1R,CTSB,FAS,FOS,HSPA4,HSPA5,ITGAV,ITGB2,MAP2K3,MAT2A,MMP14,MMP9,NINJ1,PDIA6,PVR,TFRC,VCAM1	4	apoptosis of pheochromocytoma cell lines,high bone mass disease,infection by RNA virus,transmigration of phagocytes	19% (3/16)	
6.881	31	3	EIF4E,PI3K (family),PIK3R1	23	AKR1C1/AKR1C2,BCL2L1,CAPG,CAPZB,CCND2,CEBPB,CTSD,CXCL12,DDIT3,FOS,GPS2,HIF1A,HMOX1,HRAS,HSPA5,LEP,MMP9,NFE2L2,PHB,PKM,PLAU,RHOG,VCAM1	5	cell viability of tumor cell lines,disorder of basal ganglia,invasion of tumor cell lines,metastasis,phagocytosis of phagocytes	60% (9/15)	
6.803	13	1	SNAI2	7	BSG,CDC42,CXCL12,MMP14,MMP9,SOX9,TP63	5	cell movement of phagocytes,export of molecule,formation of lamellipodia,metabolism of protein,proliferation of tumor cells	20% (1/5)	
6.656	19	5	ANGPT2,CYB5R4,IGF1R,LDL,TCR	13	APP,BCL2L1,CD4,CEBPB,DDIT3,EIF2S1,FAS,GSK3B,HIF1A,HMOX1,HSPA5,SCD,SOD1	1	autophagy of cells	0% (0/5)	
6.147	19	3	ANGPT2,IGF1R,LDL	14	APP,BCL2L1,CALR,CEBPB,DDIT3,FAS,GSK3B,HDAC2,HIF1A,HMOX1,HSPA5,IL10RA,SOD1,THBS1	2	autophagy of cells,response of macrophages	0% (0/6)	
5.963	65	4	FLI1,miR-1-3p (and other miRNAs w/seed GGAAUGU),MITF,RICTOR	52	ANXA2,APOE,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V0D1,ATP6V1A,ATP6V1B2,ATP6V1E1,ATP6V1F,BCL2L1,BIRC7,BSG,CCND3,CD4,CLCN3,EDNRB,EGR1,FAU,HACD3,HPGDS,KIT,NPM1,PRKCE,PSMA3,PSMA4,PSMA5,PSMB5,PSMC4,PSMD14,PSMD2,RPL13A,RPL38,RPL7A,RPL9,RPLP0,RPS10,RPS11,RPS13,RPS19,RPS21,RPS24,RPS29,RPS3,RPS4Y1,RPS5,RPSA,SLC25A1,SOX9,TCP1,UHMK1,XPO6	9	cell death of osteosarcoma cells,export of molecule,interphase of tumor cell lines,receptor-mediated endocytosis,replication of Influenza A virus,synthesis of fatty acid,viral entry by Influenza virus,viral entry of carcinoma cell lines,viral entry of lung cancer cell lines	3% (1/36)	
5.927	38	3	FGF2,HGF,miR-16-5p (and other miRNAs w/seed AGCAGCA)	31	ANLN,ARHGDIA,ATF4,BCL2L1,CA12,CCND2,CCND3,CD28,CDK6,CYR61,EDNRB,EGR1,FAS,GBA,HIF1A,HK1,HMOX1,JUNB,LGMN,MMP14,PHB,RAD51C,SLC20A1,SLC7A1,SPP1,STAB1,TFPI,THBS1,TNFRSF1A,TOP2A,VCAM1	4	anemia,chronic kidney disease,failure of kidney,glomerulosclerosis	25% (3/12)	
5.774	32	3	INSIG1,MAPK9,SIRT1	27	ADIPOQ,ALOX5AP,APOE,BCL2L1,CEBPB,CNR1,EGR1,ELOVL1,FOS,HMOX1,LEP,LIPA,MMP9,NR1D1,NR1H3,PCK1,PCYT2,PLIN2,PMVK,PTX3,RAD23B,SCD,SERPINA1,SREBF1,SREBF2,THRA,UCP2	2	quantity of adipose tissue,synthesis of lipid	67% (4/6)	
5.756	31	6	AGT,CEBPB,IL1,NFkB (complex),SPP1,TNFSF11	22	ADAM17,APOE,APP,CAPN2,CSF1,CSF1R,CTSS,CXCL12,EDNRB,FOS,GDF15,GSK3B,ITGAV,ITGB2,MMP14,MMP9,PFN1,PLAU,SHC1,TFPI,TNFRSF1A,VCAM1	3	high bone mass disease,shape change of tumor cell lines,transmigration of cells	17% (3/18)	
5.750	21	3	CSF1,SP1,SPP1	16	ADIPOQ,C1QBP,CD28,CTGF,CXCL12,FCGR2A,FLNA,ITGAV,KIT,MMP9,MSR1,PDGFA,PLAU,PRKCE,THBS1,VCAM1	2	cell spreading,formation of lamellipodia	17% (1/6)	
5.657	12	1	GDF2	8	CXCL12,FOS,HIF1A,HSPB8,MMP9,NINJ1,SLC3A2,SPP1	3	cellular homeostasis,organismal death,quantity of metal	33% (1/3)	
5.578	24	2	GAST,HRG	17	ANXA7,ATF4,C1QA,CD83,CXCL14,EGR1,FOS,IMPDH2,MMP9,NARS,ODC1,PHB,POR,RPS19,SLC4A2,SPP1,VCAM1	5	cell movement,generation of cells,organismal death,proliferation of muscle cells,quantity of carbohydrate	40% (4/10)	
5.421	31	3	ANGPT2,ATF4,F2	23	ABCC1,B3GNT5,CALR,CEBPB,DDIT3,FAS,GNA13,GSK3B,HDAC2,HIF1A,HMOX1,HSPA5,LEP,MAPK10,NUPR1,PLAU,PRKCE,PTX3,SOD1,THBS1,TRAF3,TRIB3,VCAM1	5	autophagy of cells,engulfment by macrophages,metabolism of glycolipid,response of phagocytes,response of tumor cell lines	7% (1/15)	
5.421	31	3	INSIG1,mir-122,NCOR-LXR-Oxysterol-RXR-9 cis RA	23	AACS,ACTR1A,ALDOA,ALOX5AP,APOC1,APOE,ELOVL1,FKBP1A,IRF8,KIF5B,LETM1,LIPA,MAP1B,NUTF2,PKM,PLIN2,PLTP,SCD,SLC1A5,SLC7A1,SREBF1,UCP2,VPS4A	5	cell death of liver,fatty acid metabolism,quantity of adipose tissue,synthesis of purine nucleotide,transport of molecule	13% (2/15)	
5.199	35	3	GPX1,IL5,NFYA	29	ANXA2,ATF4,BCL2L1,CALR,CD14,CD63,CDC42,CHMP1A,CYBB,EGR1,F8,FAS,FGFR2,HIF1A,HSPA5,HSPH1,ITGAV,MAT2A,MLH1,MMP9,PAX5,PDIA6,SLC1A5,SOD1,STK39,TNFRSF1A,TOP2A,TXN,VCAM1	3	activation of leukocytes,inflammatory response,Viral Infection	44% (4/9)	
4.919	28	3	BID,Cdc42,TFEB	20	ADAM17,APP,ARSA,ATP6V1A,C3AR1,CLCN7,CSF1,CTSA,CTSB,CTSD,CTSS,FAS,GBA,GSK3B,HEXA,LAMP2,NAGLU,PSAP,SGSH,TPP1	5	catabolism of sphingolipid,immune response of cells,lysosomal storage disease,Movement Disorders,proteolysis	13% (2/15)	
4.914	37	2	CSF1,FUT8	28	APOE,BCL2L1,CCND2,CD209,CSF1R,CYP1B1,DUSP1,EGR1,FAS,FCER1G,FCGR2A,FOS,GDF15,GSTM3,GSTM5,IL11RA,ITGAV,MMP9,MSR1,NFE2L2,PLAU,PTPRC,SFRP1,STAB1,TFRC,THBS1,TNFRSF1A,VCAM1	7	advanced malignant tumor,cell spreading,endocytosis,export of lipid,formation of cellular protrusions,interphase of tumor cell lines,synthesis of fatty acid	43% (6/14)	
4.818	26	5	AGT,AKT1,estrogen receptor,SMARCA4,SYVN1	19	ADAM12,ADAM9,ANXA1,ATP6AP1,CALR,CD4,CEBPB,CSF1,CTSB,DAB2,FCGR2A,FLNC,GSK3B,HMOX1,MMP14,PFN1,PTX3,SLC3A2,TREM2	2	engulfment of tumor cell lines,fusion of cells	10% (1/10)	
4.715	18	1	VEGFA	13	ABCC1,COX8A,CTSB,CTSS,CXCL12,HIF1A,HMOX1,IGFBP4,MMP9,NME2,SLC25A5,SLC25A6,THBS1	4	biosynthesis of nucleoside triphosphate,biosynthesis of purine ribonucleotide,growth of organism,response of antigen presenting cells	25% (1/4)	
4.670	37	2	FOS,SPP1	31	ADAM12,ADIPOQ,ARF1,CAPN2,CD14,CD68,CLDN2,CLIP1,CTGF,CTSB,CXCL12,DSP,ENAH,FGFR2,GSK3B,HMOX1,HSPA5,ITGAV,LRP8,MAP4K4,MMP14,MMP9,NFE2L2,PDGFA,PFN1,PLAU,PRKCE,RAPGEF3,SEMA3B,SIRPA,VCAM1	4	binding of cells,cell spreading,invasion of tumor,migration of breast cancer cell lines	50% (4/8)	
4.477	26	1	SPI1	22	C3AR1,CCND2,CD14,CHI3L1,CSF1,CSF1R,CTSS,CYBB,DAB2,DUSP6,FCER1G,FOS,HSPA8,IL1RN,ITGB2,KIT,KLF4,LTF,LYZ,PTPRC,RACK1,SPP1	3	inflammatory response,phosphorylation of protein,release of metal	67% (2/3)	
4.389	21	2	HIF1A,mir-122	15	ADIPOQ,ALDOA,APOE,BCL2L1,CTPS1,CXCL12,FOS,ITGAV,ITGB2,LETM1,MMP9,PKM,PPIA,SOCS3,TGFB2	4	apoptosis of liver,biosynthesis of purine ribonucleotide,function of myeloid cells,metabolism of nucleoside triphosphate	25% (2/8)	
4.379	30	5	ACOX1,KRAS,PIK3R1,PPARGC1A,TP63	23	ABCB11,ADIPOQ,BCL2L1,CYR61,DDIT3,FAS,FTH1,GSTP1,HMOX1,IL1RN,LONP1,NFE2L1,NFE2L2,NQO1,PHYH,PLAU,PRDX5,PRNP,SCD,SOD1,TNFRSF1A,TXN2,UCP2	2	inflammation of liver,quantity of reactive oxygen species	40% (4/10)	
4.330	16	1	PRL	12	ANXA2,APP,CAPN2,CTSB,CTSD,CTSS,GNA12,MMP14,PROX1,RHOG,SPP1,TP63	3	invasion of tumor,migration of phagocytes,response of tumor cell lines	0% (0/3)	
4.170	29	4	HGF,HIF1A,IGF1R,LDL	23	ADIPOQ,ALDOA,APOE,APP,BCL2L1,CD28,CEBPB,CXCL12,DDIT3,EDNRB,EGR1,GBA,HK1,HMOX1,HSPA5,LGMN,NPM1,PKM,SESN2,SLC20A1,SLC7A1,TFRC,VCAM1	2	anemia,autophagy of cells	25% (2/8)	
4.017	36	4	ANGPT2,CSF2,MAP2K1,TCR	30	APOE,BCL2L1,BSG,CD14,CD4,CEBPB,CSF1,CTGF,CTSB,DDIT3,FAS,FLNA,GDF15,GSK3B,HIF1A,HMOX1,HSPA5,LEP,MMP14,MMP9,NME1,PLAU,PRNP,QSOX1,SERPINA1,SOD1,SPP1,SQSTM1,THBS1,TRAF3	2	autophagy of cells,invasion of tumor	25% (2/8)	
3.962	27	3	CSF2,MAP2K1,PRL	23	ANXA2,APOE,BSG,CAPN2,CD14,CSF1,CTGF,CTSB,CTSS,FAS,FLNA,GDF15,GNA12,HIF1A,HSPA5,LEP,MMP14,MMP9,PLAU,PROX1,RHOG,SPP1,THBS1	1	invasion of tumor	0% (0/3)	
3.175	15	2	GPX1,Ifn gamma	12	BCL2L1,CD14,CHI3L1,CYBB,FAS,IRF8,LGALS9,MMP9,PSME1,SOD1,TNFRSF1A,VCAM1	1	activation of leukocytes	50% (1/2)	
3.175	16	2	GDNF,MKNK1	12	ANXA2,FLNA,FOS,GNB1,HSD11B2,KIT,MAP1B,MAPT,PLTP,PPP1R1B,PRKACA,THRA	2	fertility,quantity of metal ion	0% (0/4)	
3.162	47	4	APP,MAP4K4,mir-1,XBP1	40	ADAM12,AK1,ALDOA,ALG14,ANXA2,APOE,ARF6,ATOX1,CDC42,CFL1,CLTC,COPB1,COPG1,CSF1R,CYCS,FAS,FKBP1A,FLNA,GAPDH,GORASP2,GSK3B,MAPT,MBP,MMP9,NDUFB7,NDUFS6,PDIA6,PLAU,PPIB,PRNP,SDC4,SEC61A1,SEC61G,SIRPA,SOD1,STIP1,TPP1,TUBB,TWF1,UQCRC1	3	formation of tau aggregates,infection of tumor cell lines,organization of organelle	0% (0/12)	
2.828	11	1	KRAS	8	BCL2L1,FAS,FTH1,GBA,NFE2L2,NQO1,PLAT,SQSTM1	2	degeneration of central nervous system,quantity of reactive oxygen species	50% (1/2)	
2.711	27	3	CD40LG,IGF1,PSEN1	23	ATP6V1A,BCL2L1,CLUH,DCLK1,DUSP1,EGR1,EIF2S1,FKBP1A,FSCN1,HMOX1,HSPD1,IL10RA,MAP2K3,MMP9,MSR1,PLAU,PPIA,PRNP,PTPRC,SOCS3,SPP1,STAB1,TUBB	1	replication of virus	33% (1/3)	
2.412	14	1	SIRT1	11	ADIPOQ,BCL2L1,CNR1,HMOX1,KLF2,LEP,MAPT,MMP9,NR1D1,SREBF1,UCP2	2	ion homeostasis of cells,synthesis of lipid	50% (1/2)	
2.000	7	2	HGF,IL13	4	LGMN,MMP14,PHB,TNFRSF1A	1	interstitial fibrosis of kidney	50% (1/2)	
2.000	11	1	TP53	9	ANXA2,CSF1,HDAC2,HRAS,KIT,PRKCE,SESN2,SHC1,SPP1	1	formation of vesicles	100% (1/1)	
1.789	7	1	Vegf	5	DDIT3,DUSP4,FAS,GNA13,IGFBP3	1	apoptosis of kidney cell lines	0% (0/1)	
1.768	11	2	miR-30c-5p (and other miRNAs w/seed GUAAACA),NFE2L2	8	ABCC1,ABCC3,ADCYAP1,SLC1A4,SLC38A1,SLC7A1,SLC7A11,SOD1	1	transport of amino acids	0% (0/2)	
1.633	8	1	SREBF1	6	DGKQ,FAS,LEP,NR1H3,SCD,THRSP	1	concentration of phospholipid	100% (1/1)	
1.606	26	5	ESRRA,miR-122-5p (miRNAs w/seed GGAGUGU),NR1I2,PSEN2,TET2	19	APP,C3AR1,CHST11,EEF1A1,GAPDH,GNB1,GOT1,GYS1,HS6ST1,ITGB2,KLF2,LTF,NR1D1,PGD,PLIN1,SCD,SMARCA4,SREBF1,XYLT1	2	formation of filaments,synthesis of carbohydrate	0% (0/10)	
1.437	36	2	HTT,miR-483-3p (miRNAs w/seed CACUCCU)	31	APP,CDH11,CDK2AP1,CNR1,CSF1R,CTGF,CTSD,DUSP6,EDNRB,ERP29,FGF1,FKBP4,GAPDH,HIF1A,HRAS,HSPA8,JUNB,MAPKAPK2,NDUFS4,NFE2L2,PFN1,SIRPA,SOCS3,SOD1,SPP1,SQSTM1,STXBP1,THRA,TUBB,UCHL1,VCAM1	3	formation of cytoskeleton,Neurodegeneration,phosphorylation of protein	17% (1/6)	
1.342	8	1	Collagen(s)	5	ACTB,C3AR1,CD68,CYR61,THBS1	2	binding of cells,formation of cytoskeleton	50% (1/2)	
1.155	5	1	KLF3	3	DEGS1,NSMAF,UGCG	1	metabolism of sphingolipid	0% (0/1)	
1.109	17	3	Cg,FMR1,HIF1A	13	ADIPOQ,APOE,CEBPB,CXCL12,EGR1,FOS,ITGB2,MMP9,PLAT,PLAU,PPIA,SPP1,TGFB2	1	function of myeloid cells	0% (0/3)	
1.066	26	3	KDM5A,RB1,SHC1	22	ACTB,BCL2L1,CTGF,EGR1,FAS,FOS,FTH1,FTL,GHITM,GPS2,GSTP1,HMOX1,HRAS,NDUFA13,NDUFA2,NDUFS4,NME1,PARK7,SQSTM1,TUBG1,TXN,UQCRC1	1	Movement Disorders	33% (1/3)	
1.000	12	2	MXI1,NCSTN	9	CD68,CEBPB,CSF1R,CTSG,FCER1G,FCGR2A,GRN,SLC1A4,SLC7A1	1	inflammation of joint	0% (0/2)	
0.530	36	3	CD3,EIF2AK4,miR-133a-3p (and other miRNAs w/seed UUGGUCC)	32	AHCYL1,ALAS1,ARL3,ATF4,BCL2L1,CERS2,CTGF,CYC1,CYCS,DDIT3,EGR1,FOS,FTL,GAPDH,GBP1,HINT1,HMGN1,HSPA5,HSPA8,ID4,JUNB,MBP,NFE2L2,NME1,NPM1,NR4A1,PFN1,PKM,PSAT1,RPS3A,SORL1,XRCC6	1	disorder of basal ganglia	0% (0/3)	
0.277	18	3	DAP3,TRIB3,UCP1	13	ALAS1,ATF4,CLCN3,DDIT3,DKK3,EEF1A1,GHITM,LEP,MT-ATP6,MT-ND1,MT-ND5,PSAT1,SRM	2	disorder of basal ganglia,Movement Disorders	33% (2/6)	
0.000	17	2	Collagen(s),HTT	14	ACTB,APP,C3AR1,CDH11,CTGF,FGF1,FKBP4,HRAS,JUNB,PFN1,SIRPA,THBS1,TUBB,VCAM1	1	formation of cytoskeleton	0% (0/2)	
-1.213	19	1	SPI1	17	CCND2,CD14,CD209,CSF1,CSF1R,FCER1G,FOS,HSPA8,IL1RN,ITGB2,KIT,KLF4,LTF,MBP,PSMB10,PTPRC,SPP1	1	proliferation of mononuclear leukocytes	100% (1/1)	
-1.938	47	1	TNF	45	ACTB,APOE,APP,ARL6IP5,ATF4,BCL2L1,CHI3L1,CNP,CTGF,CTSS,DDIT3,EGR1,ETV5,FOS,FOSB,FTH1,GBP1,GSK3B,GSTP1,HMOX1,HSPA8,JUNB,KCTD13,LEP,MBP,NFE2L2,NME1,NR4A1,PCDH7,PKM,PLOD2,PRNP,PSME1,RARRES3,RPSA,SCD,SDC4,SLC1A4,SNCG,SOD1,SOX9,SPP1,TNFRSF1A,TXN,UGCG	1	disorder of basal ganglia	100% (1/1)	
-3.536	10	1	TCF7L2	8	CTNNA1,FGFR2,ID4,KIF5B,PCK1,RHOG,TAF10,TP63	1	growth of organism	100% (1/1)	
-4.082	8	1	RICTOR	6	ATP6AP1,ATP6V0B,ATP6V0C,ATP6V1A,ATP6V1B2,CD4	1	viral entry of tumor cell lines	0% (0/1)	
-4.919	7	1	RICTOR	5	ATP6V0C,BSG,PSMC4,RPS19,RPSA	1	death of embryo	0% (0/1)	
-5.145	36	1	IFNG	34	ACTB,ADRA2A,AHCY,APP,ARL6IP5,ATF4,BCL2L1,CNR1,CSE1L,CTGF,CTSS,DDIT3,EEF1A1,EGR1,FOS,FOSB,FTH1,FTL,GBP1,HMOX1,HSPA8,JUNB,LEP,NR1D1,PPIA,PPP1R1B,PRNP,PSME1,RARRES3,SDC4,SERPINA1,SPP1,TNFRSF1A,ZBTB16	1	disorder of basal ganglia	100% (1/1)	
-6.000	6	1	MAFF	4	ABCC3,GSTP1,NQO1,TXNRD1	1	cell death	0% (0/1)	
-6.124	8	1	CD38	6	ALDOA,ALDOC,GBE1,PFKL,PKM,SOCS3	1	metabolism of carbohydrate	0% (0/1)	
-6.500	6	1	mir-210	4	ABCC3,CXCL12,NCAM1,PSAP	1	fatty acid metabolism	0% (0/1)	
-8.083	5	1	ITCH	3	CYR61,FOS,TP63	1	colony formation of cells	0% (0/1)	
-8.660	5	1	RUVBL1	3	CCND2,IGFBP3,SESN2	1	phosphorylation of protein	0% (0/1)	
-16.743	5	1	GNE	3	ASNS,DDIT3,TRIB3	1	cell death of tumor cell lines	100% (1/1)	
-16.743	5	1	MYC	3	CTSD,LEP,LYZ	1	hydrolysis of polysaccharide	0% (0/1)	
-22.517	7	1	SKIL	3	ADAM12,CDH11,CXCL12	3	adhesion of connective tissue cells,invasion of tumor cell lines,migration of tumor cell lines	0% (0/3)	
Networks for My Projects->David Bulger->P3
ID	Analysis	Molecules in Network	Score	Focus Molecules	Top Diseases and Functions	
1	P3	AES,CBX4,CCAR2,CEP170B,EAF1,EPRS,ERICH2,FLYWCH2,GARS,GNB1,HNRNPA0,IPO4,KCTD1,KCTD15,KIFC3,LSM1,MARK1,NARS,NCDN,NR1D1,OSGIN1,PGAM1,PNMA1,PSME3,PTP4A3,RAB5C,SDCBP,SDCCAG3,SENP3,SLC4A2,SUMO3,THAP11,TXNDC12,UBQLN1,VPS11	42	35	Cell Death and Survival, Cellular Assembly and Organization, Cellular Function and Maintenance	
2	P3	APP,ATRAID,Aspartyl Protease,BHMT2,C9orf142,DIRAS1,FAM126B,FAM127B,FAM49A,FILIP1,GTF3C6,GYG2,HCFC1R1,HIGD2A,IGSF6,IMP4,JTB,KIAA1191,KRTCAP2,LARP6,LHFPL2,LURAP1L,MMEL1,MRPL52,NTMT1,RASL12,RNF24,SH3BGRL3,SLC41A3,SLC48A1,SPX,THSD4,TOMM5,VWA5A,WARS2	39	34	Cancer, Cellular Development, Cellular Growth and Proliferation	
3	P3	AASS,DCTD,DYNLT1,ERAL1,GPC4,ICMT,ICT1,MALSU1,MAPRE3,MRPL14,MRPL17,MRPL21,MRPL24,MRPL30,MRPL37,MRPL43,MRPL47,MRPL51,MRPL54,MRPL55,MRPS16,MRPS2,MRPS30,MRPS7,NGRN,PUSL1,PVR,RPL13,RPS8,Ras,SUPV3L1,TIGIT,TRUB2,TXN2,YARS2	39	34	Cellular Assembly and Organization, Cellular Function and Maintenance, Metabolic Disease	
4	P3	ABHD4,BHLHE41,BTBD2,BZW2,CENPB,COPS3,COPS7A,COPS8,CSNK2B,DCTN3,DEAF1,FAM117B,FIBP,FKBP14,GSK3B,KEAP1,KIF5B,KLHL18,KLHL42,LMO4,MBD4,MID1IP1,MT-TY,NRBP1,PCCB,PDGF-CC,PEX7,PHYH,RCN3,STXBP4,TSC22D2,TSEN15,WDR1,WDR18,WSB1	39	34	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
5	P3	CERS2,CHMP1A,CHMP2A,CHTOP,CNBP,CNR1,Cyclin B,DDX3Y,DIP2C,EEF1B2,ERH,FANCE,FYTTD1,HIST1H2BK,IGSF8,KCND3,MARS,NDN,PCBD1,PCDH18,POLR1A,RNA polymerase I,RPS10,RPS15,RPS19,RPS2,RPS3,RPS3A,RPS4Y1,RPS5,RPSA,RRP1B,TRIOBP,VPS4A,ZNF358	37	33	Tissue Morphology, Infectious Diseases, Protein Synthesis	
6	P3	ASS1,C1QBP,C6orf62,CLEC9A,EDNRB,ENaC,FADS3,FAM129A,FHL1,HYOU1,IL10RA,IMMT,KIAA0232,LONP1,MECOM,MECR,MINOS1,MS4A7,Mitochondrial complex 1,NDUFA13,NDUFA4L2,NUAK1,PHB,PHB2,PNKD,SEPHS1,SERPINE2,SFXN4,SLC25A11,SLC25A13,SLC25A5,SLC35F6,ST3GAL6,ST6GALNAC2,STOML2	37	33	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
7	P3	ADRM1,ARL6IP5,AUP1,C20orf24,CD3G,CLGN,CLN5,CLN6,CXCL12,DAD1,DERL1,DIP2B,FNDC4,GCNT2,GHITM,OST4,PIGU,PRAF2,PSMD,PSMD3,PSMD7,PSMD8,Proteasome PA700/20s,RAD23B,RNF185,RPN1,RPN2,SEL1L,SERINC2,STT3A,STT3B,TMEM129,USMG5,YIPF2,dolichyl-diphosphooligosaccharide-protein glycotransferase	34	32	Post-Translational Modification, Developmental Disorder, Hereditary Disorder	
8	P3	ALAS1,C7orf50,C8orf33,Calmodulin,DDX21,DKC1,EBNA1BP2,HMBOX1,NHP2,NOP10,NPAS2,POLD2,POLDIP2,REXO4,RPL12,RPL13A,RPL14,RPL18,RPL30,RPL31,RPL35,RPL37A,RPL4,RPL7A,RPL8,RPL9,RPLP0,RPLP1,SNU13,SYT2,T3-TR-RXR,TRP,TTC23,URB1,ZNF768	34	32	Cancer, Cell Death and Survival, Organismal Injury and Abnormalities	
9	P3	AREL1,Adaptor protein 2,BAG3,C12orf10,CCDC85B,CECR1,Ck2,DGCR6L,DTX4,FBXO10,GCSH,HNRNPK,HSP90AB1,Histone h4,KAZN,KCNG1,KIF1A,LZTS2,MACROD1,NOL6,PAFAH1B2,PCNXL2,PEX10,PREB,RPL24,RUVBL1,SETBP1,SLC47A1,SPATA20,ST6GALNAC4,STARD7,TP63,UBE2I,ZBTB16,ZC3H7B	34	32	Cancer, Cellular Development, Organismal Injury and Abnormalities	
10	P3	26s Proteasome,ALG8,ARRDC2,B3GAT3,BSG,C9orf91,CCDC58,CEBPB,COX7A2L,CYSTM1,DDX49,DUSP1,EARS2,EVC,HISTONE,HLCS,HSPA5,KLF8,MAPT,MEGF9,MMP14,MYH1,NRSN2,NUPR1,PXDC1,SAMD1,SHMT2,SMARCA4,SPATS2L,SPP1,SQSTM1,STXBP6,UBIAD1,Ubiquitin,ZFAS1	34	32	Cellular Compromise, Cellular Function and Maintenance, Cancer	
11	P3	ATXN2L,C15orf39,CFTR,CRAT,CSF1R,DAB2,EIF5A,EPSTI1,ETF1,ETS,FARSA,FARSB,GSPT1,HAX1,IFRD2,MLF2,MSC,P4HA1,P4HA2,PAX5,PSMD2,SARS,SEC61A1,SEC61G,SEPT3,SEPT9,STS,Septin,Sfk,TARS,TCF,TCF7,TIAL1,TMEM33,UBA5	32	31	Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry	
12	P3	AARS,Ap1,BANF1,BCAS2,C3orf17,C7orf49,CBX3,DCLK2,ENO1,H2AFZ,HMGA1,Hat,LSM12,LSM3,LSM4,MGAT1,NPM1,POLE3,PRPF19,RPA,RSL24D1,SDAD1,SLC25A39,SMOC2,SNRNP25,SNRPD1,SNRPD2,SNRPD3,SNRPF,SOX17,SZRD1,TXNL4A,UBL5,XRCC6,snRNP	32	31	RNA Post-Transcriptional Modification, Cellular Assembly and Organization, Cell Cycle	
13	P3	ABR,ALOX5AP,ARL2,CLCN3,CLDN5,COL15A1,COL8A1,CSTA,DGKG,DGKQ,DNA-methyltransferase,Dgk,EFR3A,GCC1,HMBS,HOXA10,HOXA6,HOXB5,ID4,LAMA2,LOC284023,ME1,METTL23,MTORC2,NAB2,NADPH oxidase,OAZ1,PAG1,PHF1,REM1,ROR1,Rac,SERPINH1,VAC14,ZBED8	30	30	Cardiovascular System Development and Function, Cell Morphology, Cellular Development	
14	P3	ACAD11,AIF1,ALT,ARL3,BCAP29,BCAP31,CHST11,CHST2,COPB1,COPE,COPG1,Cr3,EPHX1,FIS1,GPAA1,HADHB,HS6ST1,ITGB2,LCP1,LEO1,MCOLN3,POMGNT1,RMND1,Rab5,SDF4,SLC27A3,SRPRA,SRPRB,STXBP1,STXBP5,Snare,THEM6,TMX2,UST,sulfotransferase	30	30	Cellular Assembly and Organization, Infectious Diseases, Carbohydrate Metabolism	
15	P3	CBX5,DYNLL1,EML4,FBXW11,FGD6,GAB2,GLUL,HDAC2,HLTF,Hdac1/2,KCMF1,KIAA0930,KLHL11,LPIN2,MKI67,MTSS1L,Mi2,NIPSNAP3A,NuRD,OGT,R3HDM1,SDHC,SH3RF3,SPIRE1,TRIM28,TUBB,UBE2A,UHRF1BP1L,WDR61,WHSC1,YWHAB,YWHAG,ZNF483,succinate dehydrogenase,tubulin (complex)	30	30	Cardiovascular Disease, Connective Tissue Disorders, Dermatological Diseases and Conditions	
16	P3	ATF4,Alp,BCAT1,C3AR1,CREBL2,CYBB,Cg,DDIT3,DOCK8,EGR1,ESR2,EXOSC5,FGF1,FMO1,G6PC3,GDF15,HMOX1,KCNK15,KIT,KLF4,LIMCH1,Lh,MAP2K1/2,PDGF BB,PKM,PLAT,PRNP,PTRH1,RAB7A,SCUBE1,SDC4,SERPINA1,SOX9,TENM4,TNFRSF12A	30	30	Cellular Development, Cellular Growth and Proliferation, Organ Development	
17	P3	C6,C8,CMA1,COA3,COX14,COX17,COX4I1,COX5A,COX7B,COX8A,CPA3,HIGD1A,ISLR,LETM1,LPCAT4,LRP8,MPC1,MT-CO1,NCSTN,NDUFA4,NID2,NPL,PRELP,Presenilin,RNF187,SCO2,SGPL1,SLC7A2,SURF1,Secretase gamma,TIE1,VAPA,Vegf,cytochrome-c oxidase,dystroglycan	29	29	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
18	P3	3 beta HSD,ACOT1,ACOT4,ACTR1A,AIFM2,CIDEA,DEGS1,FTL,GFPT1,Insulin,NADH dehydrogenase,NDUFA1,NDUFA11,NDUFA6,NDUFB4,NDUFB7,NDUFB9,NDUFS8,NUCB2,PEA15,PPT1,PRDX1,PRDX5,RTN3,RTN4,SCAMP2,SLC16A1,SPG21,TBC1D7,TMEM43,TPO,UQCC2,palmitoyl-CoA hydrolase,peroxidase (miscellaneous),sGC	29	29	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
19	P3	ACAP2,ALG3,ANKRD9,ARF6,CD83,FAR2,GNL3,IMPDH2,IgG2a,IgG2b,Igg3,Ikb,LASP1,LPAR1,Lymphotoxin,MAT2A,MFSD5,MPEG1,NCLN,NDPK,NME1,PABPC4,PDGFA,PYCARD,RCC2,SELT,SLC25A44,SLC3A2,SLC5A3,TALDO1,TNFAIP8L2,TRAF3,UNG,VSIG4,YARS	29	29	Inflammatory Response, Cellular Function and Maintenance, Developmental Disorder	
20	P3	ADM2,ATP synthase,ATP5G1,ATP5I,ATP5J2,ATP5L,BIRC7,CLCN7,F0 ATP synthase,FAM124B,FOLR2,FOS,GAS5,Has,IL11RA,INTERLEUKIN,LPCAT3,OSTM1,PCDH19,PCYT2,PXK,RFNG,RGMA,SCN7A,SDK1,SEC23B,SP2,Sec23,TAX1BP3,TBCA,TLN2,TMED1,XYLT1,adenosine-tetraphosphatase,ornithine decarboxylase	27	28	Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder	
21	P3	ALDOC,ATP5H,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V0D1,ATP6V1A,ATP6V1B2,ATP6V1E1,ATP6V1F,CMC2,CTSA,Gsk3,H+-exporting ATPase,H+-transporting two-sector ATPase,HACD3,HEXA,LAMTOR4,MLST8,MTORC1,NAGLU,RRAGC,RRAGD,S6K1,SESN2,SESN3,SGSH,SLC1A5,SLC36A1,SLC7A5,SNX10,TFEB,TMBIM6,Vacuolar H+ ATPase,aldo	27	28	Molecular Transport, Infectious Diseases, Cellular Function and Maintenance	
22	P3	AAGAB,AAK1,AP1B1,AP2S1,AP3D1,ARAP1,ARF1,ASAP2,ATG9,ATG9A,Ap1 gamma,Ap2 alpha,BIN1,CAPZB,CLTC,COP I,Clathrin,DLGAP4,Dynamin,ELOVL1,FAM102A,GTPBP2,GULP1,IFI30,MAL2,MYO1D,PLEKHO2,Pi3k class III,SH3GL1,SH3GLB1,SHANK2,SHC1,TECR,TWF1,TWF2	27	28	Cell Signaling, Post-Translational Modification, Protein Synthesis	
23	P3	ARSA,Adaptor protein 1,BCKDK,BMPER,CCNI,CDK16,CETN2,CPEB1,DCLK1,FBXO8,FSTL3,IL12 (family),LITAF,LMCD1,MBP,MIF4GD,NFKBIZ,OTUB2,PLP1,RBCK1,RNF165,RNF43,STAM,Smad1/5/8,Smad2/3,TGFBR,TMSB10/TMSB4X,TMSB4,TMSB4Y,TRIM55,UBE2D2,UBE2E1,UBE2K,XIST,arginase	27	28	Post-Translational Modification, Neurological Disease, Cellular Assembly and Organization	
24	P3	AFF3,AHSA1,ANKMY2,ATOX1,C11orf68,Calcineurin A,DNAAF5,DPM1,FKBP1A,FKBP2,FKBP3,FKBP4,FKBP5,GBA,GLB1,Gm-csf,HLA-DR,Neurotrophin,P2RY8,PHLDA3,PLOD2,PPIA,PPIB,PPIL1,PREPL,PSAP,RARS2,RET,STIP1,Shc,TMEM11,TUBA1B,XPO5,chemokine receptor,peptidylprolyl isomerase	27	28	Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	
25	P3	14-3-3,ANXA1,ANXA2,ASNA1,ATXN10,BTG2,C1orf123,CAPN2,CAPN6,CAPNS1,CTNNA1,Cyclin E,EIF4E2,ERP29,FOSB,G0S2,HMGN1,HRAS,IGFBP4,LIMA1,LIMS1,LYZ,MAP1B,MTHFD1L,NEXN,PTPRQ,PYGO2,RABL6,RAP1GDS1,Rb,SERCA,Spectrin,TOP2A,Top2,calpain	27	28	Cell Death and Survival, Cellular Growth and Proliferation, Cancer	

My Lists for My Projects->David Bulger->P3
My Lists	 -log(p-value)	Ratio	Molecules 

Tox Lists for My Projects->David Bulger->P3
Ingenuity Toxicity Lists	 -log(p-value)	Ratio	Molecules 
Mitochondrial Dysfunction	1.8E01	3.24E-01	ATP5D,ACO2,COX8A,ATP5L,NCSTN,NDUFA4L2,NDUFA1,VDAC2,NDUFS6,UQCRFS1,NDUFA8,SURF1,SDHC,UQCR11,COX7A1,NDUFA6,TXN2,NDUFB7,MAPK10,NDUFA12,VDAC1,NDUFA4,COX7B,ATP5G1,ATP5H,UQCRH,PRDX5,NDUFA2,NDUFB9,PARK7,MT-CYB,ATP5J2,OGDH,ATP5I,COX4I1,NDUFS4,MT-CO1,MT-ATP6,NDUFB4,COX17,UCP2,GLRX2,NDUFV3,COX7A2L,NDUFA13,APP,FIS1,MT-ND5,MT-ND1,NDUFS8,NDUFA11,UQCR10,CYC1,COX5A,CYCS,UQCRC1,UQCRQ
NRF2-mediated Oxidative Stress Response	9.02E00	2.19E-01	MAF,HRAS,DNAJC15,ABCC1,KEAP1,ATF4,GSK3B,TXN,GCLM,GSTM3,JUNB,TXNRD1,DNAJC5,ERP29,RBX1,STIP1,DNAJC18,MAP2K3,SQSTM1,ACTG1,CYP4A11,HACD3,GSTP1,EPHX1,FTH1,AKR7A2,GSTM5,PPIB,PRDX1,NQO2,DNAJA4,HSPB8,MAFG,HMOX1,HSP90AB1,DNAJC4,UBE2K,GSTM4,PRKCE,FMO1,FKBP5,NFE2L2,ACTB,NQO1,MAP3K1,DNAJC1,SOD1,FOS,FTL,CCT7,AOX1
Renal Necrosis/Cell Death	5.96E00	1.53E-01	GFPT1,CTGF,CCNI,UNC5B,HRAS,C1QA,HSPA5,APRT,SGPL1,RHOG,ABCC1,CDON,MCOLN3,ITGAV,NEO1,GNA13,GSK3B,RET,DPM3,HK1,SPP1,GNG2,SDHC,HAX1,BCL2L1,CDC42,DUSP1,MAPT,IGFBP3,GAPDH,TFRC,DUSP4,SFRP1,VDAC1,GSTP1,APOE,TFEB,DDIT3,GSTM5,PYCARD,LRP6,HYOU1,PPIA,HIF1A,FAS,HMOX1,STUB1,THBS1,ERBB4,ANXA5,AAK1,PRKCE,NFE2L2,ATP13A2,GMFB,TMEM123,PRNP,PLAT,TNFRSF1A,GNA12,MAP3K1,TRIB3,SOD1,APP,FGF1,EMP1,FOS,TNFAIP8L2,MYOC,GLIS2,CSF1,SREBF2,NTRK3,PEA15,CYCS,PLAU,ABCC3,SLC47A1
Liver Necrosis/Cell Death	3.94E00	1.57E-01	SOCS3,APOE,SCD,DDIT3,ADIPOQ,FKBP1A,UGCG,HRAS,TAF10,TMBIM6,FAS,PTPRC,TACR1,SLC19A3,HMOX1,SHC1,ARF6,FLNA,ENTPD5,SAA1,ITGAV,GSK3B,NFE2L2,SLC20A1,TNFRSF1A,TYROBP,CEBPB,HSPD1,SOD1,NFE2L1,APP,RBCK1,BCL2L1,ITGB2,FOS,LAMP2,IL1RN,BMF,SERPINH1,CTSB,CD14,DUSP4,IRF8,SLC25A5,MMP9
Cardiac Necrosis/Cell Death	3.65E00	1.56E-01	SOCS3,SCD,LEP,SFRP2,CTSG,ADIPOQ,HSPB8,HIF1A,FAS,IRAK1,HMOX1,CAMK2D,PARK7,PHB,HSPE1,CYBB,GSK3B,MAPKAPK2,DSP,HSPB6,PLAT,HK1,S100A1,CALR,CALCRL,SPP1,FSTL3,HDAC2,PPIF,MAP3K1,HSPD1,PKN1,BCL2L1,MTPN,IL1RN,RTN4,GAPDH,MAP2K3,CYR61,SGCD,ADRA1A,RPSA
Acute Renal Failure Panel (Rat)	3.59E00	2.42E-01	VCAM1,EGR1,GDF15,CXCL12,FKBP1A,ANXA2,TUBB,TNFRSF12A,MYO5A,FOS,HMOX1,CD68,ANXA1,CD14,SLC30A1
Oxidative Stress	3.47E00	2.46E-01	VCAM1,PRDX5,PRDX1,GSTM3,GLRX2,NQO1,SOD1,ME1,GSS,NFE2L1,FOS,DUSP1,GCLM,NFE2L2
Persistent Renal Ischemia-Reperfusion Injury (Mouse)	3.08E00	3E-01	SOCS3,LYZ,VCAM1,LAPTM5,CTSS,MMP14,C1QC,SOX9,C1QB
Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane	2.77E00	5.71E-01	BCL2L1,BTG2,OGDH,HSPA5
Liver Proliferation	2.75E00	1.49E-01	SOCS3,CTGF,LEP,MMP14,CXCL12,ADIPOQ,HRAS,PROX1,GPC3,FAS,ODC1,TNFRSF12A,CCND3,THBS1,ENTPD5,CXCL14,ITGAV,SLC7A5,ATF4,GSK3B,NFE2L2,SLC20A1,FST,SPP1,EDNRB,TNFRSF1A,CNR1,FGFR2,CEBPB,FOS,IL1RN,SERPINH1,CTSB,C3AR1
Increases Heart Failure	2.54E00	3.04E-01	MTPN,CAMK2D,PPIF,DUSP6,PLAU,SLC9A1,MMP9
Cardiac Hypertrophy	2.42E00	1.27E-01	APOB,PFN1,CTGF,PFKFB1,LDB3,CXCL12,HRAS,SLC9A1,CTSD,PLCE1,CAMK2D,GAA,CYBB,PNKD,PLIN5,GSK3B,TXN,FSTL3,HDAC2,RAPGEF3,HMGA1,DES,KLF4,LMCD1,MYL9,MTPN,ADRA2A,DUSP1,CTSB,MAP2K3,ESR2,APOE,FHL1,ADAM17,RAB4A,RAB1A,LEP,PDGFA,GDF15,ADIPOQ,HSPB8,PPIA,FKBP1A,HIF1A,H2AFZ,SHC1,HMOX1,PARK7,PRKCE,PLAT,TRIM55,PRMT5,PLAU,ADRA1A,MMP9
LPS/IL-1 Mediated Inhibition of RXR Function	2.3E00	1.39E-01	ALDH4A1,APOE,GSTM5,HS2ST1,CES2,ALAS1,SLC27A4,IRAK1,CHST2,HS6ST1,UST,ALDH3A2,GSTM4,ABCB11,CHST11,FMO1,HMGCS1,ALDH1B1,ACSL3,TNFRSF1A,GSTM3,MAP3K1,NR1H3,ALDH1L2,SREBF1,IL1RN,ALDH1A2,APOC1,CD14,NR5A2,PLTP,SLC27A3,ABCC3,CYP4A11,GSTP1
Aryl Hydrocarbon Receptor Signaling	2.14E00	1.5E-01	ALDH4A1,ALDH1B1,GSTM5,GSTM3,NQO2,NQO1,CDK6,SMARCA4,CYP1B1,FAS,NR2F1,CTSD,FOS,CCND2,ALDH1L2,CCND3,HSP90AB1,ALDH3A2,ALDH1A2,GSTM4,TGFB2,ESR2,NFE2L2,GSTP1
Swelling of Mitochondria	2.12E00	3.33E-01	BCL2L1,PRKCE,SOD1,DES,FAS
Xenobiotic Metabolism Signaling	2.01E00	1.27E-01	ALDH4A1,GSTM5,AKR1C3,NQO2,HS2ST1,MAF,HRAS,CES2,CHST2,HMOX1,HS6ST1,CES1,CAMK2D,HSP90AB1,UST,KEAP1,ALDH3A2,GSTM4,CHST11,PRKCE,FMO1,HPGDS,NFE2L2,ALDH1B1,SRA1,AKR1C1/AKR1C2,GSTM3,NQO1,MAP3K1,CYP1B1,PPP2R1A,FTL,DHRS9,ALDH1L2,CYP4B1,RBX1,ALDH1A2,MAP2K3,ABCC3,PPP2R1B,GSTP1,SCAND1,EPHX1
Nongenotoxic Hepatocarcinogenicity Biomarker Panel	1.99E00	2.73E-01	SEL1L,LITAF,BTG2,PPIA,ANXA2,CES2
Increases Liver Steatosis	1.88E00	1.65E-01	SCD,APOE,GPS2,CNR1,ADIPOQ,NPC1L1,PNRC2,PSME3,HMOX1,SREBF1,DUSP1,PLIN2,ATF4,CD14,KLF2
TR/RXR Activation	1.78E00	1.65E-01	AKR1C1/AKR1C2,UCP2,AKR1C3,GPS2,THRA,ME1,HIF1A,PCK1,THRSP,ENO1,TBL1Y,SREBF1,SREBF2,SYT2
RAR Activation	1.77E00	1.37E-01	AKR1C3,MNAT1,RPL7A,SMARCA4,NR2F1,TGFB2,PRKCE,NR2F6,CSNK2B,MAPKAPK2,ZBTB16,ADCY2,SRA1,ACTB,MAP3K1,FOS,DHRS9,DUSP1,ALDH1A2,ADCY1,MAPK10,IGFBP3,PRKACA,HLTF,CARM1,SCAND1
Glutathione Depletion - CYP Induction and Reactive Metabolites	1.77E00	3.33E-01	TKT,GSTM4,ABCC3,EPHX1
Long-term Renal Injury Anti-oxidative Response Panel (Rat)	1.76E00	2.78E-01	HMOX1,GSTM5,GCLM,SOD1,GSS
Increases Cardiac Dysfunction	1.72E00	2.05E-01	PTX3,SCD,FSTL3,CYBB,FKBP1A,DUSP4,PLAU,MMP9
Hypoxia-Inducible Factor Signaling	1.72E00	1.71E-01	SHC1,UBE2D2,UBE2A,HSP90AB1,NQO1,EIF2B3,HRAS,HIF1A,EIF2S1,UBE2E1,EIF2S2,UBE2I
Cardiac Fibrosis	1.7E00	1.35E-01	APOE,PFKFB1,RRM2B,HSPB8,CTNNA1,HRAS,HMOX1,PNKD,CYBB,NDUFS6,GSK3B,DSP,PLAT,PTX3,SPP1,SGCG,FSTL3,NPY1R,EGR1,DES,CAPNS1,ADRA2A,LIMS1,PLAU,SGCD,MMP9
Decreases Depolarization of Mitochondria and Mitochondrial Membrane	1.63E00	2.31E-01	ABCC1,SH3GLB1,PPIA,VDAC1,FAS,CSTB
Increases Permeability Transition of Mitochondria and Mitochondrial Membrane	1.56E00	3.75E-01	FAM162A,COX4I1,APP
Glutathione Depletion - Hepatocellular Hypertrophy	1.56E00	3.75E-01	POR,FMO1,ABCC3
FXR/RXR Activation	1.28E00	1.35E-01	APOE,APOB,SLC4A2,CYP27A1,NR1H3,SAA2,G6PC3,PCK2,SREBF1,IL1RN,SAA1,MAPK10,APOC1,ABCB11,NR5A2,SERPINA1,PLTP
Increases Cardiac Proliferation	1.28E00	1.7E-01	ITGB2,HMOX1,LEP,RAB1A,PLCE1,ADIPOQ,GNL3,FGF1
Increases Liver Damage	1.28E00	1.37E-01	TNFRSF1A,PYCARD,EGR1,FAS,CERS2,ITGB2,BSG,IL1RN,KEAP1,SAA1,CTSB,CD14,MAP2K3,PLAU,MMP9,GSTP1
Increases Renal Proliferation	1.21E00	1.3E-01	STT3B,PTP4A3,MMP14,TTLL4,HRAS,FGFR2,HSPD1,MMP25,CSF1R,GRN,PPP2R1A,PLCE1,MYOC,SDCBP,CSF1,PLAU,VDAC1,SLC30A1
Increases Depolarization of Mitochondria and Mitochondrial Membrane	1.16E00	2.22E-01	PEBP1,BTG2,CYR61,PRNP
Increases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	1.15E00	1.6E-01	BCL2L1,HSPA4,PHB,PPP1R1B,PRKCE,CYCS,ZBTB16,FAS
LXR/RXR Activation	1.12E00	1.3E-01	SCD,APOE,APOB,MSR1,TNFRSF1A,NR1H3,SAA2,LYZ,SREBF1,IL1RN,SAA1,APOC1,CD14,SERPINA1,PLTP,MMP9
VDR/RXR Activation	1.09E00	1.41E-01	IGFBP6,SPP1,PDGFA,HOXA10,IGFBP3,TGFB2,PRKCE,CD14,SEMA3B,CEBPB,KLF4
Renal Proximal Tubule Toxicity Biomarker Panel (Rat)	1.07E00	1.85E-01	SPP1,SLC25A11,SLC38A3,GSTP1,GJB2
Fatty Acid Metabolism	1.04E00	1.28E-01	ACAD11,ALDH1B1,ALDH4A1,ACSL3,DHRS9,CYP4B1,ALDH3A2,ALDH1A2,ACAD8,HADHB,SLC27A3,IVD,CYP4A11,SLC27A4,CYP1B1
Glutathione Depletion - Phase II Reactions	1.03E00	2E-01	GSTM5,GSTM3,GSTM4,GSTP1
Hepatic Fibrosis	9.65E-01	1.29E-01	IGFBP6,IGFBP4,LEP,SPP1,THBS1,SREBF1,CSF1,PDGFA,MMP14,IGFBP3,TGFB2,MMP9,FGF1
Genes associated with Chronic Allograft Nephropathy (Human)	9.64E-01	1.9E-01	VCAM1,PDGFA,THBS1,MMP9
Positive Acute Phase Response Proteins	9.19E-01	1.67E-01	HMOX1,SAA1,SERPINA1,SAA2,C1QB
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARα	8.79E-01	1.26E-01	NR2F1,SHC1,FOS,SRA1,HSP90AB1,PDGFA,DUSP1,TNFRSF1A,NR1H3,HRAS,ME1,SCAND1
Hormone Receptor Regulated Cholesterol Metabolism	8.15E-01	2.5E-01	ABR,NR1H3
Cholesterol Biosynthesis	7.88E-01	1.88E-01	MVD,PMVK,HMGCS1
Hepatic Cholestasis	6.99E-01	1.1E-01	ADCY2,SLC4A2,CYP27A1,TNFRSF1A,NR1H3,IRAK1,SREBF1,IL1RN,ABCC1,ADCY1,MAPK10,TGFB2,PRKACA,ABCB11,CD14,PRKCE,NR5A2,ABCC3
Increases Liver Hepatitis	6.78E-01	1.27E-01	ITGB2,SPP1,LEP,TNFRSF1A,CD14,CYR61,FAS
Cytochrome P450 Panel - Substrate is a Fatty Acid (Human)	6.59E-01	2E-01	CYP4B1,CYP4A11
PXR/RXR Activation	6.46E-01	1.21E-01	SCD,PCK2,ALDH3A2,PRKACA,ABCB11,CES2,ALAS1,ABCC3
Increases Cardiac Dilation	6.35E-01	1.43E-01	CAMK2D,FSTL3,PLAU,MMP9
CAR/RXR Activation	6E-01	1.38E-01	CYP2B7P,CES1,PCK1,ABCC3
Decreases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	5.98E-01	1.09E-01	BCL2L1,SHC1,CISD1,CD28,SLC25A6,UCP2,IMMT,DDIT3,PYCARD,RTN4,VDAC1,FAS,APP
Cytochrome P450 Panel - Substrate is a Fatty Acid (Rat)	5.96E-01	1.82E-01	CYP4B1,CYP4A11
p53 Signaling	5.89E-01	1.11E-01	SCO2,BCL2L1,CCND2,TP63,THBS1,RRM2B,GNL3,HIF1A,GSK3B,FAS,SERPINE2
Protection from Hypoxia-induced Renal Ischemic Injury (Rat)	5.09E-01	2.5E-01	HMOX1
Pro-Apoptosis	5.05E-01	1.19E-01	TRAF3,TNFRSF1A,DAPK2,BMF,FAS
Long-term Renal Injury Pro-oxidative Response Panel (Rat)	4.93E-01	1.54E-01	CYBB,FMO1
Irreversible Glomerulonephritis Biomarker Panel (Rat)	4.93E-01	1.54E-01	SPP1,TMSB10/TMSB4X
Cytochrome P450 Panel - Substrate is a Sterol (Human)	4.5E-01	1.43E-01	CYP27A1,CYP1B1
Cytochrome P450 Panel - Substrate is a Sterol (Mouse)	4.5E-01	1.43E-01	CYP27A1,CYP1B1
Cytochrome P450 Panel - Substrate is a Sterol (Rat)	4.5E-01	1.43E-01	CYP27A1,CYP1B1
Recovery from Ischemic Acute Renal Failure (Rat)	4.5E-01	1.43E-01	SPP1,TMSB10/TMSB4X
Cell Cycle: G1/S Checkpoint Regulation	4.37E-01	1.06E-01	CCND2,HDAC2,CCND3,CDK6,TGFB2,GNL3,GSK3B
Genes Upregulated in Response to Chronic Renal Failure (Rat)	4.31E-01	2E-01	ABCC3
Hepatic Stellate Cell Activation	4.26E-01	1.14E-01	PDGFA,TGFB2,CD14,KLF2
Increases Bradycardia	4.12E-01	1.33E-01	CALR,ADRA2A
Cytochrome P450 Panel - Substrate is a Fatty Acid (Mouse)	3.77E-01	1.25E-01	CYP4B1,CYP4A11
Reversible Glomerulonephritis Biomarker Panel (Rat)	3.65E-01	1.11E-01	LIPA,IGFBP3,ALOX5AP
Increases Renal Nephritis	3.41E-01	1E-01	CD28,LEP,CSF1,FCGR2A,TNFRSF1A
Cytochrome P450 Panel - Substrate is a Vitamin (Mouse)	3.22E-01	1.43E-01	CYP27A1
Cytochrome P450 Panel - Substrate is a Vitamin (Rat)	3.22E-01	1.43E-01	CYP27A1
Cytochrome P450 Panel - Substrate is a Xenobiotic (Human)	3.18E-01	1.11E-01	CYP2B7P,CYP1B1
Anti-Apoptosis	2.62E-01	9.38E-02	BCL2L1,BIRC7,BAG3
Renal Ischemic Resistance Panel (Rat)	2.19E-01	1E-01	SPP1
Genes Upregulated in Response to Proteinuria-induced Oxidative Stress in Renal Proximal Tubule Cells (Human)	2.19E-01	1E-01	COMT
Increases Damage of Mitochondria	1.95E-01	9.09E-02	FAS
Primary Glomerulonephritis Biomarker Panel (Human)	1.95E-01	9.09E-02	EGR1

My Pathways for My Projects->David Bulger->P3
My Pathways	 -log(p-value)	Ratio	Molecules 

Analysis Ready Molecules for My Projects->David Bulger->P3
ID	Symbol	Expr Fold Change	Expr p-value	Expr False Discovery Rate (q-value)
ENSG00000081760	AACS	-2.04727376	9.71E-5	0.003019657
ENSG00000103591	AAGAB	2.239931574	3.19458E-4	0.00790029
ENSG00000115977	AAK1	1.730256597	4.72E-5	0.001667665
ENSG00000090861	AARS	3.108535372	2.18E-17	1.06E-14
ENSG00000149313	AASDHPPT	2.059277651	6.05E-5	0.0020523
ENSG00000008311	AASS	-2.284508377	2.89E-5	0.001109307
ENSG00000073734	ABCB11	5.500704456	5.06E-17	2.35E-14
ENSG00000103222	ABCC1	3.300936953	3.24E-17	1.55E-14
ENSG00000108846	ABCC3	5.15126002	1.4E-15	5.54E-13
ENSG00000091262	ABCC6	1.841227658	3.27575E-4	0.008066827
ENSG00000100997	ABHD12	2.15219208	5.37E-5	0.001850434
ENSG00000100439	ABHD4	3.442203199	7.33E-15	2.59E-12
ENSG00000159842	ABR	1.814878399	3.62E-5	0.001340966
ENSG00000240303	ACAD11	1.957340343	6.05E-6	3.04431E-4
ENSG00000151498	ACAD8	1.759468586	1.42432E-4	0.004114412
ENSG00000114331	ACAP2	1.641402335	3.594E-4	0.008616052
ENSG00000100412	ACO2	2.066393751	3.33E-5	0.001254883
ENSG00000184227	ACOT1	3.464319621	1.41278E-4	0.004093376
ENSG00000177465	ACOT4	3.628519141	2.33E-7	1.87E-5
ENSG00000134575	ACP2	2.26223941	6.7E-7	4.72E-5
ENSG00000167107	ACSF2	2.286020618	6.17E-7	4.39E-5
ENSG00000123983	ACSL3	2.706210523	1.23E-7	1.06E-5
ENSG00000183549	ACSM5	-4.629023671	3.69E-7	2.81E-5
ENSG00000111058	ACSS3	-2.312186669	4.28505E-4	0.009895386
ENSG00000075624	ACTB	1.85387908	8.45E-5	0.002701228
ENSG00000184009	ACTG1	2.568158924	8.5E-10	1.35E-7
ENSG00000072110	ACTN1	2.249738002	1.64E-8	1.89E-6
ENSG00000138107	ACTR1A	1.790882417	1.0899E-4	0.003320314
ENSG00000115091	ACTR3	1.782717476	3.95E-5	0.001441228
ENSG00000123612	ACVR1C	-2.350031921	3.94988E-4	0.009278331
ENSG00000148848	ADAM12	3.082134741	6.92E-12	1.59E-9
ENSG00000151694	ADAM17	2.0146216	2.15E-5	8.66969E-4
ENSG00000168615	ADAM9	1.742275617	1.15718E-4	0.00348387
ENSG00000166106	ADAMTS15	2.74499737	3.56E-9	4.84E-7
ENSG00000154736	ADAMTS5	2.49215883	4.48E-11	8.95E-9
ENSG00000134917	ADAMTS8	5.092398137	4.4E-7	3.25E-5
ENSG00000241158	ADAMTS9-AS1	-2.349823355	9.84E-5	0.003055671
ENSG00000184060	ADAP2	2.417005669	9.11E-5	0.002876786
ENSG00000133597	ADCK2	3.360321875	1.21E-5	5.34935E-4
ENSG00000164742	ADCY1	6.766575478	1.02E-45	3.74E-42
ENSG00000078295	ADCY2	-2.553622421	3.43326E-4	0.008326778
ENSG00000141433	ADCYAP1	5.560392713	6.96E-6	3.40088E-4
ENSG00000078549	ADCYAP1R1	2.491426282	2.14E-6	1.25654E-4
ENSG00000121753	ADGRB2	4.245866712	8.8E-12	1.97E-9
ENSG00000111452	ADGRD1	-6.381281596	1.49E-8	1.73E-6
ENSG00000072071	ADGRL1	2.089001767	8.31E-7	5.6E-5
ENSG00000181092	ADIPOQ	-2.144041013	3.6501E-4	0.008741757
ENSG00000128165	ADM2	2.602286589	2.29845E-4	0.006023999
ENSG00000144843	ADPRH	2.84380577	1.93E-6	1.15225E-4
ENSG00000116863	ADPRHL2	2.245156471	1.33E-5	5.7489E-4
ENSG00000120907	ADRA1A	2.932266353	1.25E-6	7.91E-5
ENSG00000150594	ADRA2A	-3.872579478	1.14E-9	1.74E-7
ENSG00000130706	ADRM1	2.397054705	1.06E-7	9.38E-6
ENSG00000104964	AES	1.728814459	3.38916E-4	0.008249147
ENSG00000196526	AFAP1	3.215756809	2.21E-12	5.36E-10
ENSG00000144218	AFF3	3.864559094	3.93E-36	6.7E-33
ENSG00000173744	AGFG1	1.835454401	9.93E-5	0.003078117
ENSG00000204310	AGPAT1	1.650446793	1.88703E-4	0.005128578
ENSG00000101444	AHCY	2.809186741	1.48E-8	1.72E-6
ENSG00000168710	AHCYL1	1.888758462	1.48E-5	6.36417E-4
ENSG00000158467	AHCYL2	1.636420544	2.64733E-4	0.006757496
ENSG00000100591	AHSA1	1.888312746	1.77E-5	7.40511E-4
ENSG00000186063	AIDA	1.762800609	9.27E-5	0.002906754
ENSG00000204472	AIF1	2.520982634	6.34E-8	5.97E-6
ENSG00000042286	AIFM2	2.017019132	1.07E-6	6.93E-5
ENSG00000106992	AK1	2.136490641	6.27E-6	3.14087E-4
ENSG00000085662	AKR1B1	4.01670111	7.77E-29	8.84E-26
ENSG00000151632	AKR1C1/AKR1C2	3.423071459	1.42E-16	6.24E-14
ENSG00000196139	AKR1C3	2.841067408	1.27E-13	3.72E-11
ENSG00000053371	AKR7A2	2.482526552	3.31E-7	2.56E-5
ENSG00000023330	ALAS1	3.170814855	5.95E-13	1.55E-10
ENSG00000170017	ALCAM	2.036642355	1.99255E-4	0.005351449
ENSG00000128918	ALDH1A2	-2.655743046	5.41E-5	0.001857259
ENSG00000137124	ALDH1B1	2.285197737	1.65E-5	6.9774E-4
ENSG00000136010	ALDH1L2	3.03550643	7.72E-21	5.05E-18
ENSG00000072210	ALDH3A2	2.399724063	4.89E-8	4.78E-6
ENSG00000159423	ALDH4A1	3.213177175	4.11E-8	4.09E-6
ENSG00000149925	ALDOA	2.365868314	4.27E-7	3.17E-5
ENSG00000109107	ALDOC	-2.652871813	9.54E-5	0.00297636
ENSG00000172339	ALG14	2.654343506	3.74584E-4	0.008912961
ENSG00000214160	ALG3	2.633018408	4.5E-8	4.45E-6
ENSG00000159063	ALG8	1.877622062	5.25E-5	0.001814323
ENSG00000171094	ALK	-4.783333835	4.23E-5	0.001525702
ENSG00000132965	ALOX5AP	2.585759954	4.9E-8	4.78E-6
ENSG00000198796	ALPK2	-3.793103338	7.68E-5	0.002500425
ENSG00000136383	ALPK3	-3.177822352	7.32E-5	0.002404163
ENSG00000162551	ALPL	6.779437613	1.93E-30	2.49E-27
ENSG00000159461	AMFR	2.158855886	3.29E-7	2.56E-5
ENSG00000126016	AMOT	-2.015722208	9.02E-5	0.002856947
ENSG00000141552	ANAPC11	2.237910013	4.76E-6	2.483E-4
ENSG00000130173	ANGPTL8	7.504476646	3.96E-21	2.63E-18
ENSG00000166839	ANKDD1A	1.764767736	4.5E-5	0.00160791
ENSG00000106524	ANKMY2	2.211150909	3.51E-7	2.69E-5
ENSG00000215559	ANKRD20A11P	-9.601938833	3.38E-5	0.001268902
ENSG00000186481	ANKRD20A5P	-5.841364932	5.39E-7	3.89E-5
ENSG00000156381	ANKRD9	4.217802111	1.94E-7	1.58E-5
ENSG00000011426	ANLN	4.154900983	6.43E-5	0.002163847
ENSG00000047617	ANO2	-1.946474245	1.69495E-4	0.004722046
ENSG00000011201	ANOS1	-2.899972985	6.59E-6	3.26964E-4
ENSG00000135046	ANXA1	3.035396718	5.33E-13	1.41E-10
ENSG00000182718	ANXA2	1.720246217	9.47E-5	0.002958822
ENSG00000164111	ANXA5	2.879326516	5.22E-15	1.89E-12
ENSG00000138279	ANXA7	1.672297913	3.51035E-4	0.008483617
ENSG00000138356	AOX1	-2.895902273	2.51E-7	1.99E-5
ENSG00000100280	AP1B1	1.685028712	2.24903E-4	0.005917199
ENSG00000042753	AP2S1	2.32488344	8.37E-6	3.93539E-4
ENSG00000065000	AP3D1	2.428720706	5.55E-10	9.21E-8
ENSG00000169188	APEX2	2.008712007	4.0E-5	0.001454933
ENSG00000084234	APLP2	1.738393311	3.96E-5	0.001444568
ENSG00000163382	APOA1BP	2.850888654	4.01E-10	6.79E-8
ENSG00000084674	APOB	-12.09477093	1.41E-16	6.22E-14
ENSG00000130208	APOC1	12.87048849	7.09E-44	2.42E-40
ENSG00000130203	APOE	5.720947361	1.46E-18	8.41E-16
ENSG00000100336	APOL4	-1.95353926	1.80402E-4	0.004953686
ENSG00000142192	APP	2.309614035	1.68E-8	1.92E-6
ENSG00000198931	APRT	2.000617698	1.8474E-4	0.005052476
ENSG00000186635	ARAP1	1.833999996	7.21E-5	0.002371991
ENSG00000119682	AREL1	1.72753302	2.08006E-4	0.005549039
ENSG00000143761	ARF1	2.050224632	8.84E-6	4.11669E-4
ENSG00000165527	ARF6	1.729774776	3.35991E-4	0.008190472
ENSG00000101199	ARFGAP1	2.282515283	1.19E-6	7.56E-5
ENSG00000160007	ARHGAP35	1.882139462	7.67E-6	3.67734E-4
ENSG00000141522	ARHGDIA	2.300159288	7.6E-6	3.6512E-4
ENSG00000074964	ARHGEF10L	1.877918076	5.89E-5	0.002009937
ENSG00000116584	ARHGEF2	3.495426685	1.59E-28	1.77E-25
ENSG00000213465	ARL2	1.991706313	3.67E-6	1.97923E-4
ENSG00000138175	ARL3	2.415800927	4.38E-7	3.24E-5
ENSG00000188042	ARL4C	2.400524292	1.33265E-4	0.003909919
ENSG00000144746	ARL6IP5	1.859398488	2.24E-5	8.99864E-4
ENSG00000130429	ARPC1B	2.321478701	1.5E-8	1.74E-6
ENSG00000241553	ARPC4	1.998814562	2.41E-5	9.50321E-4
ENSG00000162704	ARPC5	1.973175636	6.53E-5	0.00219251
ENSG00000136950	ARPC5L	2.250087301	2.21E-8	2.46E-6
ENSG00000105643	ARRDC2	-3.612698304	3.54085E-4	0.008518532
ENSG00000140450	ARRDC4	2.972976648	1.49E-11	3.17E-9
ENSG00000100299	ARSA	2.337583517	3.28601E-4	0.008077271
ENSG00000151693	ASAP2	1.609397616	1.88297E-4	0.005120467
ENSG00000088280	ASAP3	1.872972925	1.79321E-4	0.004932504
ENSG00000198356	ASNA1	2.500332167	2.23E-6	1.29303E-4
ENSG00000070669	ASNS	3.948750967	5.25E-18	2.76E-15
ENSG00000130707	ASS1	1.916401854	3.81871E-4	0.009032381
ENSG00000128272	ATF4	2.286592679	1.4E-10	2.6E-8
ENSG00000169136	ATF5	10.43802559	2.61E-103	4.15E-99
ENSG00000198925	ATG9A	1.79053769	1.41096E-4	0.004093376
ENSG00000138363	ATIC	2.503189595	1.02E-8	1.22E-6
ENSG00000166454	ATMIN	1.78510679	3.0204E-4	0.007531935
ENSG00000177556	ATOX1	3.099938359	1.91E-11	4.0E-9
ENSG00000206190	ATP10A	2.029468922	2.02E-6	1.19972E-4
ENSG00000159363	ATP13A2	2.686407104	4.44E-6	2.33752E-4
ENSG00000099624	ATP5D	2.244743847	1.59E-5	6.75127E-4
ENSG00000159199	ATP5G1	2.083312488	5.31E-5	0.001830753
ENSG00000167863	ATP5H	1.804464074	3.34E-5	0.001257046
ENSG00000169020	ATP5I	2.385366416	1.63E-7	1.36E-5
ENSG00000241468	ATP5J2	1.984873002	2.66562E-4	0.006788956
ENSG00000167283	ATP5L	1.919144914	7.36E-5	0.002413215
ENSG00000071553	ATP6AP1	1.635300958	3.85446E-4	0.009089942
ENSG00000117410	ATP6V0B	2.162623032	8.25E-7	5.57E-5
ENSG00000185883	ATP6V0C	2.475503615	4.42E-8	4.37E-6
ENSG00000159720	ATP6V0D1	2.059215508	5.03E-8	4.89E-6
ENSG00000114573	ATP6V1A	2.130132488	4.33E-8	4.3E-6
ENSG00000147416	ATP6V1B2	1.973137834	1.95E-5	8.01832E-4
ENSG00000131100	ATP6V1E1	2.472773258	4.65E-10	7.74E-8
ENSG00000128524	ATP6V1F	2.291240356	1.31438E-4	0.003866985
ENSG00000138085	ATRAID	1.7971784	1.82582E-4	0.005002056
ENSG00000130638	ATXN10	1.919101114	7.56E-5	0.002464614
ENSG00000168488	ATXN2L	1.842300688	2.1E-5	8.54553E-4
ENSG00000115307	AUP1	1.82893823	2.55E-5	9.97908E-4
ENSG00000175756	AURKAIP1	2.791670396	7.83E-9	9.74E-7
ENSG00000176022	B3GALT6	2.183745252	3.14773E-4	0.007800585
ENSG00000149541	B3GAT3	2.242512107	1.83E-5	7.61697E-4
ENSG00000176597	B3GNT5	2.412119428	6.35E-7	4.5E-5
ENSG00000117411	B4GALT2	2.45352411	1.04E-5	4.69592E-4
ENSG00000151929	BAG3	2.025862937	2.12E-5	8.59113E-4
ENSG00000204463	BAG6	1.69318954	3.77368E-4	0.008956908
ENSG00000175334	BANF1	2.502343882	1.55E-6	9.5E-5
ENSG00000174483	BBS1	2.445707225	2.36E-5	9.38695E-4
ENSG00000075790	BCAP29	2.423901748	5.44E-15	1.95E-12
ENSG00000185825	BCAP31	2.100437562	2.26E-5	9.05482E-4
ENSG00000116752	BCAS2	2.028682758	1.31226E-4	0.003863118
ENSG00000060982	BCAT1	3.047349934	8.37E-11	1.61E-8
ENSG00000103507	BCKDK	2.46989173	1.36979E-4	0.004000434
ENSG00000171552	BCL2L1	1.780041189	2.80853E-4	0.007097104
ENSG00000236824	BCYRN1	2.728015212	2.27E-10	4.06E-8
ENSG00000123095	BHLHE41	3.377748295	1.61E-27	1.67E-24
ENSG00000132840	BHMT2	1.593452841	1.78983E-4	0.004928905
ENSG00000136717	BIN1	2.252559583	2.25E-8	2.49E-6
ENSG00000101197	BIRC7	9.520283829	1.15E-6	7.37E-5
ENSG00000104081	BMF	2.536650819	7.74E-6	3.70123E-4
ENSG00000153162	BMP6	-3.540479023	1.14534E-4	0.003455257
ENSG00000164619	BMPER	6.795934315	1.01E-31	1.38E-28
ENSG00000237238	BMS1P10	-9.658839014	8.31E-5	0.00267092
ENSG00000078898	BPIFB2	-12.79843094	4.71E-5	0.001666328
ENSG00000164713	BRI3	2.370568354	9.43E-11	1.8E-8
ENSG00000198797	BRINP2	5.985649027	8.12E-9	9.99E-7
ENSG00000172270	BSG	2.127795462	1.52344E-4	0.004321989
ENSG00000133243	BTBD2	2.10150628	1.06E-6	6.86E-5
ENSG00000134717	BTF3L4	2.058586856	7.76E-7	5.3E-5
ENSG00000159388	BTG2	-5.837597236	6.99E-7	4.88E-5
ENSG00000154640	BTG3	2.562027533	8.7E-7	5.83E-5
ENSG00000136261	BZW2	2.345518822	5.38E-9	6.97E-7
ENSG00000177354	C10orf71	-22.68226524	2.44528E-4	0.006349616
ENSG00000171067	C11orf24	2.398714563	2.47E-9	3.54E-7
ENSG00000211450	C11orf31	2.60145456	1.84E-7	1.52E-5
ENSG00000175573	C11orf68	2.218408207	9.86E-6	4.4964E-4
ENSG00000139637	C12orf10	2.165209072	2.09E-5	8.48629E-4
ENSG00000111412	C12orf49	2.327959092	6.67E-5	0.002235859
ENSG00000156411	C14orf2	1.605844354	3.75577E-4	0.008932159
ENSG00000167173	C15orf39	2.049654828	1.68593E-4	0.004702388
ENSG00000205363	C15orf59	5.384451974	1.5E-9	2.23E-7
ENSG00000162062	C16orf59	6.989189522	4.52E-5	0.001614115
ENSG00000224877	C17orf89	2.501883582	2.15E-5	8.65951E-4
ENSG00000228300	C19orf24	3.374429893	6.84E-10	1.11E-7
ENSG00000104979	C19orf53	2.262791418	1.38E-6	8.63E-5
ENSG00000197982	C1orf122	2.734996114	1.78E-7	1.47E-5
ENSG00000162384	C1orf123	1.679366577	7.58E-5	0.002471506
ENSG00000203709	C1orf132	-2.759889414	8.02E-7	5.45E-5
ENSG00000143110	C1orf162	2.850219683	3.43E-5	0.00128105
ENSG00000143612	C1orf43	1.895343896	1.93E-5	7.96993E-4
ENSG00000173372	C1QA	3.247431773	7.1E-6	3.46232E-4
ENSG00000173369	C1QB	3.414198318	4.29E-7	3.18E-5
ENSG00000108561	C1QBP	2.662082177	9.6E-10	1.48E-7
ENSG00000159189	C1QC	3.763137472	9.13E-11	1.75E-8
ENSG00000082196	C1QTNF3	-4.892039432	1.69959E-4	0.004729451
ENSG00000101084	C20orf24	2.782528264	1.15167E-4	0.003471636
ENSG00000101220	C20orf27	3.019523538	2.74E-6	1.54462E-4
ENSG00000042304	C2orf83	-3.257442376	1.03949E-4	0.003190856
ENSG00000187699	C2orf88	2.416463134	4.02E-6	2.14399E-4
ENSG00000171860	C3AR1	3.551304651	1.22E-10	2.28E-8
ENSG00000163608	C3orf17	1.664412118	2.54208E-4	0.006558206
ENSG00000243449	C4orf48	4.854702217	2.78E-7	2.19E-5
ENSG00000161010	C5orf45	3.326341913	2.6E-33	4.28E-30
ENSG00000178722	C5orf64	-8.518907828	1.36198E-4	0.003982504
ENSG00000039537	C6	-8.272576893	1.47E-7	1.24E-5
ENSG00000188112	C6orf132	-5.983194346	1.13274E-4	0.003425385
ENSG00000204387	C6orf48	3.078404003	1.15E-13	3.41E-11
ENSG00000112308	C6orf62	1.853861947	2.97131E-4	0.007436686
ENSG00000146826	C7orf43	2.520430563	3.47E-5	0.001293363
ENSG00000122783	C7orf49	2.011671929	8.76E-5	0.002792457
ENSG00000146540	C7orf50	3.178651138	5.46E-12	1.26E-9
ENSG00000182307	C8orf33	1.907062348	3.99E-5	0.001452641
ENSG00000213563	C8orf82	2.405517919	1.72E-5	7.22516E-4
ENSG00000148362	C9orf142	2.831934583	3.22E-8	3.31E-6
ENSG00000164972	C9orf24	4.824697833	2.79E-8	2.97E-6
ENSG00000238227	C9orf69	3.808145228	3.19E-11	6.45E-9
ENSG00000147894	C9orf72	1.951099919	1.96019E-4	0.005288298
ENSG00000157693	C9orf91	1.810998914	3.23391E-4	0.007976914
ENSG00000074410	CA12	2.668401925	1.8E-6	1.089E-4
ENSG00000169239	CA5B	2.978666778	1.74E-21	1.17E-18
ENSG00000142408	CACNG8	-3.440563799	4.09821E-4	0.009546964
ENSG00000175161	CADM2	-8.673409433	1.15E-7	1.01E-5
ENSG00000162706	CADM3	2.377580913	3.72E-7	2.83E-5
ENSG00000064989	CALCRL	-2.948572994	1.85225E-4	0.005059953
ENSG00000138172	CALHM2	1.850230802	3.3377E-4	0.008157128
ENSG00000143933	CALM1 (includes others)	2.464496283	1.87E-13	5.29E-11
ENSG00000179218	CALR	1.978250926	1.13534E-4	0.003431086
ENSG00000145349	CAMK2D	2.206418065	2.88E-7	2.26E-5
ENSG00000042493	CAPG	2.681809745	6.38E-9	8.06E-7
ENSG00000162909	CAPN2	2.110252849	3.89E-8	3.92E-6
ENSG00000077274	CAPN6	5.942142952	7.84E-43	2.2E-39
ENSG00000126247	CAPNS1	2.024214337	5.19E-6	2.67844E-4
ENSG00000077549	CAPZB	1.762433993	7.55E-5	0.002463555
ENSG00000142453	CARM1	1.888984778	1.32201E-4	0.003884658
ENSG00000110619	CARS	2.669002438	1.05E-15	4.31E-13
ENSG00000147044	CASK	1.690821947	1.7362E-4	0.004800569
ENSG00000122565	CBX3	2.083646618	3.67E-6	1.97909E-4
ENSG00000141582	CBX4	3.706456609	2.63E-9	3.74E-7
ENSG00000094916	CBX5	1.61999329	2.53236E-4	0.006536664
ENSG00000183741	CBX6	2.074957137	4.76E-6	2.483E-4
ENSG00000158941	CCAR2	1.661652068	1.71512E-4	0.004753283
ENSG00000160124	CCDC58	2.567836909	1.4941E-4	0.004269533
ENSG00000166510	CCDC68	-3.972761729	1.86E-5	7.7413E-4
ENSG00000175602	CCDC85B	3.022972242	3.9E-7	2.94E-5
ENSG00000115355	CCDC88A	1.871084275	1.98E-6	1.17812E-4
ENSG00000118971	CCND2	2.443022785	1.17E-10	2.2E-8
ENSG00000112576	CCND3	1.83341222	2.02E-5	8.22642E-4
ENSG00000118816	CCNI	2.205506408	2.35E-7	1.88E-5
ENSG00000260916	CCPG1	2.818562303	7.78E-20	4.83E-17
ENSG00000107771	CCSER2	1.761723599	6.18E-5	0.002091479
ENSG00000163468	CCT3	1.890593865	8.24E-6	3.8837E-4
ENSG00000115484	CCT4	1.97563585	1.82892E-4	0.00500768
ENSG00000150753	CCT5	2.261133363	1.35E-8	1.58E-6
ENSG00000135624	CCT7	1.679571198	2.64316E-4	0.006753355
ENSG00000170458	CD14	4.640320924	1.21E-18	7.02E-16
ENSG00000177697	CD151	1.855722496	1.16E-6	7.44E-5
ENSG00000090659	CD209	4.262366678	7.66E-18	3.94E-15
ENSG00000178562	CD28	2.371000825	3.21835E-4	0.007950865
ENSG00000167850	CD300C	6.051201687	2.25076E-4	0.005918498
ENSG00000160654	CD3G	-3.003927644	1.00602E-4	0.003109625
ENSG00000010610	CD4	2.003391518	2.67E-5	0.001039121
ENSG00000169442	CD52	6.137615274	2.03E-9	2.95E-7
ENSG00000143119	CD53	2.545534049	1.93E-5	7.97148E-4
ENSG00000135404	CD63	1.948337343	2.59E-6	1.47562E-4
ENSG00000129226	CD68	2.991497058	2.77E-12	6.65E-10
ENSG00000112149	CD83	2.899004949	9.95E-6	4.52901E-4
ENSG00000070831	CDC42	1.869608563	3.36E-5	0.001261636
ENSG00000128283	CDC42EP1	2.682672545	2.49E-8	2.7E-6
ENSG00000140937	CDH11	2.666797546	6.19E-10	1.01E-7
ENSG00000145526	CDH18	-3.085933761	7.91E-6	3.76064E-4
ENSG00000101542	CDH20	-6.124248625	1.27E-5	5.57335E-4
ENSG00000102225	CDK16	1.929600126	1.86356E-4	0.00508214
ENSG00000111328	CDK2AP1	1.812592478	1.1841E-4	0.003547037
ENSG00000167797	CDK2AP2	2.029770833	2.87E-5	0.00110689
ENSG00000105810	CDK6	2.226219633	2.91E-7	2.28E-5
ENSG00000237190	CDKN2AIPNL	2.44820343	2.07195E-4	0.005539758
ENSG00000064309	CDON	2.599770742	7.59E-11	1.47E-8
ENSG00000228411	CDY4P	25.01197879	7.98E-6	3.78492E-4
ENSG00000007129	CEACAM21	-5.33014231	2.9E-5	0.001113122
ENSG00000172216	CEBPB	2.220732178	2.12431E-4	0.005641888
ENSG00000153879	CEBPG	2.175094267	2.03E-8	2.28E-6
ENSG00000093072	CECR1	1.730804578	3.41625E-4	0.00830239
ENSG00000125817	CENPB	2.490299843	3.69E-5	0.001363077
ENSG00000166582	CENPV	1.973072673	4.24201E-4	0.009819722
ENSG00000099814	CEP170B	1.982824994	1.29E-5	5.62382E-4
ENSG00000143418	CERS2	1.913253981	6.21E-5	0.002097059
ENSG00000227617	CERS6-AS1	1.735384125	1.1452E-4	0.003455257
ENSG00000198848	CES1	5.383352254	2.99E-18	1.64E-15
ENSG00000172831	CES2	2.651625022	1.63E-11	3.43E-9
ENSG00000147400	CETN2	2.074646996	8.09E-5	0.002614293
ENSG00000164323	CFAP97	1.822306649	1.40081E-4	0.004071137
ENSG00000172757	CFL1	2.189562417	4.55E-6	2.38333E-4
ENSG00000226312	CFLAR-AS1	-2.070458726	1.66753E-4	0.004661971
ENSG00000001626	CFTR	-3.989532489	2.1156E-4	0.005621869
ENSG00000128965	CHAC1	9.814145653	5.65E-13	1.48E-10
ENSG00000250479	CHCHD10	5.16282603	4.92E-18	2.61E-15
ENSG00000106153	CHCHD2	2.068555586	9.8E-6	4.47378E-4
ENSG00000170791	CHCHD7	1.768937244	2.66505E-4	0.006788956
ENSG00000131778	CHD1L	2.83046098	1.5E-9	2.23E-7
ENSG00000133048	CHI3L1	4.828786237	9.86E-13	2.49E-10
ENSG00000131165	CHMP1A	1.927271154	3.53228E-4	0.008506483
ENSG00000130724	CHMP2A	1.790494957	3.43E-5	0.00128105
ENSG00000171310	CHST11	2.446507645	8.45E-9	1.03E-6
ENSG00000175040	CHST2	5.014766839	7.71E-20	4.83E-17
ENSG00000160679	CHTOP	1.748674398	1.54052E-4	0.004360451
ENSG00000176194	CIDEA	-9.82324819	2.77E-12	6.65E-10
ENSG00000186162	CIDECP	1.890370185	7.34E-5	0.002408735
ENSG00000122873	CISD1	2.229853953	3.12935E-4	0.00775906
ENSG00000125931	CITED1	5.752219344	9.99E-8	8.96E-6
ENSG00000109572	CLCN3	2.590146938	6.2E-11	1.23E-8
ENSG00000073464	CLCN4	2.27445296	9.63E-6	4.4207E-4
ENSG00000103249	CLCN7	2.294467623	3.33E-6	1.83326E-4
ENSG00000165376	CLDN2	-15.57641388	1.35441E-4	0.0039628
ENSG00000184113	CLDN5	-2.360302018	2.71026E-4	0.00688063
ENSG00000197992	CLEC9A	-4.878997661	1.65612E-4	0.004635481
ENSG00000153132	CLGN	11.73167811	2.37E-40	5.97E-37
ENSG00000159212	CLIC6	-2.547644993	1.48822E-4	0.004262429
ENSG00000130779	CLIP1	1.613620074	1.18569E-4	0.003549556
ENSG00000102805	CLN5	1.834836349	7.28E-5	0.002393084
ENSG00000128973	CLN6	1.929186729	1.71436E-4	0.004753283
ENSG00000104853	CLPTM1	2.331964145	1.56E-9	2.31E-7
ENSG00000158258	CLSTN2	-6.787848801	1.81E-13	5.13E-11
ENSG00000141367	CLTC	1.905117726	2.61E-5	0.001020746
ENSG00000132361	CLUH	1.970135754	3.73225E-4	0.008898353
ENSG00000092009	CMA1	4.077583709	1.92E-7	1.57E-5
ENSG00000103121	CMC2	2.371792673	1.19E-7	1.03E-5
ENSG00000184220	CMSS1	1.85934116	1.61137E-4	0.004534141
ENSG00000140931	CMTM3	2.456303022	2.36941E-4	0.006176101
ENSG00000180917	CMTR2	1.956463222	3.97337E-4	0.009306058
ENSG00000169714	CNBP	2.069409586	2.17E-6	1.26896E-4
ENSG00000133313	CNDP2	2.151915679	3.27E-8	3.35E-6
ENSG00000100528	CNIH1	2.309288606	1.21302E-4	0.003613271
ENSG00000182973	CNOT10	2.415391919	9.22E-15	3.24E-12
ENSG00000173786	CNP	1.872478246	9.21E-6	4.25719E-4
ENSG00000118432	CNR1	-2.139021056	2.60623E-4	0.006669682
ENSG00000119865	CNRIP1	2.262856959	7.34E-8	6.74E-6
ENSG00000152910	CNTNAP4	-6.018375699	1.22E-5	5.37818E-4
ENSG00000183978	COA3	2.094136191	3.35E-5	0.001260087
ENSG00000204291	COL15A1	2.159045758	8.39E-5	0.00268833
ENSG00000084636	COL16A1	2.585577094	6.28E-14	1.96E-11
ENSG00000196739	COL27A1	1.720410078	3.89609E-4	0.009174522
ENSG00000204262	COL5A2	2.214163671	4.58E-7	3.36E-5
ENSG00000080573	COL5A3	2.818531798	9.42E-14	2.85E-11
ENSG00000142156	COL6A1	2.02265602	2.3245E-4	0.006082271
ENSG00000144810	COL8A1	-3.014970457	9.09E-7	6.04E-5
ENSG00000130309	COLGALT1	2.374114892	3.14E-12	7.46E-10
ENSG00000114744	COMMD2	2.060439615	1.18E-7	1.03E-5
ENSG00000093010	COMT	2.272191397	6.69E-8	6.24E-6
ENSG00000129083	COPB1	1.681212309	4.19855E-4	0.009756932
ENSG00000105669	COPE	2.964185552	7.75E-6	3.70123E-4
ENSG00000181789	COPG1	1.818922783	3.51931E-4	0.00849235
ENSG00000141030	COPS3	1.808008921	3.09459E-4	0.007692849
ENSG00000111652	COPS7A	1.82995145	1.97329E-4	0.005308667
ENSG00000198612	COPS8	2.230143189	3.99E-5	0.001452641
ENSG00000178449	COX14	1.72072921	2.83532E-4	0.007152532
ENSG00000138495	COX17	2.866113477	1.97E-8	2.23E-6
ENSG00000131143	COX4I1	1.892164019	2.34573E-4	0.006127743
ENSG00000178741	COX5A	2.072484805	3.99813E-4	0.009354873
ENSG00000161281	COX7A1	2.251060882	3.12167E-4	0.007744044
ENSG00000115944	COX7A2L	2.248380379	3.48E-6	1.89863E-4
ENSG00000131174	COX7B	1.961407069	2.0E-5	8.16828E-4
ENSG00000176340	COX8A	2.363156067	2.99442E-4	0.00748276
ENSG00000163751	CPA3	5.238258975	2.51E-24	2.35E-21
ENSG00000160111	CPAMD8	-3.70361922	3.61E-8	3.67E-6
ENSG00000214575	CPEB1	3.423884062	1.89E-7	1.55E-5
ENSG00000113742	CPEB4	2.602881119	4.59E-9	6.01E-7
ENSG00000135678	CPM	-2.752535501	9.61E-6	4.41337E-4
ENSG00000196353	CPNE4	-3.894579056	1.8165E-4	0.004985095
ENSG00000095321	CRAT	1.928055497	5.93E-6	3.00032E-4
ENSG00000111269	CREBL2	1.780063912	1.94305E-4	0.00525393
ENSG00000143162	CREG1	2.001732807	1.64E-5	6.92928E-4
ENSG00000103196	CRISPLD2	-3.015610534	9.19E-8	8.32E-6
ENSG00000103316	CRYM	4.460633586	8.49E-8	7.75E-6
ENSG00000124207	CSE1L	1.936035464	6.63E-6	3.27644E-4
ENSG00000184371	CSF1	2.280619425	2.85E-6	1.59738E-4
ENSG00000182578	CSF1R	2.452127782	7.85E-7	5.35E-5
ENSG00000204435	CSNK2B	1.674413169	3.23002E-4	0.007971432
ENSG00000173546	CSPG4	2.214489204	1.03E-5	4.64395E-4
ENSG00000144655	CSRNP1	-4.05896236	6.47E-6	3.22495E-4
ENSG00000110925	CSRNP2	2.09263059	5.38E-8	5.18E-6
ENSG00000121552	CSTA	4.902377897	3.72E-23	2.96E-20
ENSG00000160213	CSTB	4.160252439	5.9E-25	5.63E-22
ENSG00000176102	CSTF3	2.149154406	1.62E-6	9.9E-5
ENSG00000159692	CTBP1	1.875135588	1.46E-5	6.27897E-4
ENSG00000175826	CTDNEP1	2.150691327	3.6E-8	3.67E-6
ENSG00000118523	CTGF	-3.250075821	1.94518E-4	0.005256721
ENSG00000044115	CTNNA1	1.749163225	1.21148E-4	0.003612743
ENSG00000171793	CTPS1	2.368466259	1.48535E-4	0.004259815
ENSG00000064601	CTSA	1.92089349	7.12E-5	0.002355247
ENSG00000164733	CTSB	2.731505384	1.27E-15	5.08E-13
ENSG00000117984	CTSD	3.738356733	3.32E-19	2.01E-16
ENSG00000100448	CTSG	3.648136188	1.01E-7	8.97E-6
ENSG00000163131	CTSS	1.986214667	8.57E-6	4.01653E-4
ENSG00000107611	CUBN	2.6562031	1.43E-10	2.64E-8
ENSG00000107562	CXCL12	2.054063891	1.76E-5	7.35189E-4
ENSG00000145824	CXCL14	2.562540993	4.28E-10	7.22E-8
ENSG00000161921	CXCL16	2.672351901	1.25E-10	2.33E-8
ENSG00000103018	CYB5B	1.828488437	1.05034E-4	0.003216944
ENSG00000165168	CYBB	2.366322156	1.45E-7	1.22E-5
ENSG00000179091	CYC1	2.372941111	1.62265E-4	0.004560508
ENSG00000172115	CYCS	2.806015786	3.48E-12	8.23E-10
ENSG00000161544	CYGB	2.953227122	3.9E-10	6.64E-8
ENSG00000138061	CYP1B1	1.89453231	4.26285E-4	0.009853644
ENSG00000135929	CYP27A1	2.714203441	3.17E-8	3.29E-6
ENSG00000256612	CYP2B7P	-3.727228183	9.82E-5	0.003051125
ENSG00000187048	CYP4A11	-4.628175496	2.28E-7	1.83E-5
ENSG00000142973	CYP4B1	-6.287287936	1.09E-14	3.82E-12
ENSG00000142871	CYR61	-4.14102814	8.61E-6	4.02783E-4
ENSG00000120306	CYSTM1	2.48118964	9.42E-10	1.46E-7
ENSG00000153071	DAB2	2.052306275	1.71E-6	1.04094E-4
ENSG00000129562	DAD1	2.229589725	7.46E-7	5.13E-5
ENSG00000226950	DANCR	2.241063774	1.51E-6	9.33E-5
ENSG00000035664	DAPK2	-2.542639175	2.99E-8	3.15E-6
ENSG00000198876	DCAF12	1.867732775	1.69783E-4	0.00472732
ENSG00000133083	DCLK1	1.86779245	1.60021E-4	0.004508053
ENSG00000170390	DCLK2	3.185179723	1.91E-14	6.38E-12
ENSG00000129187	DCTD	1.860043446	2.78274E-4	0.007045928
ENSG00000137100	DCTN3	2.321946914	1.17E-6	7.48E-5
ENSG00000169738	DCXR	1.850731226	3.27711E-4	0.008066827
ENSG00000175197	DDIT3	6.381516297	3.05E-27	3.04E-24
ENSG00000165732	DDX21	1.745554055	4.31107E-4	0.00993625
ENSG00000067048	DDX3Y	32.37649783	3.8E-71	3.02E-67
ENSG00000105671	DDX49	3.013911923	1.87E-7	1.54E-5
ENSG00000177030	DEAF1	2.165379078	6.33E-5	0.002132345
ENSG00000186458	DEFB132	-18.3422981	8.49E-10	1.35E-7
ENSG00000143753	DEGS1	2.210162743	3.51E-10	6.02E-8
ENSG00000136986	DERL1	2.090522428	4.85E-7	3.55E-5
ENSG00000175084	DES	-9.681598916	4.09497E-4	0.009544068
ENSG00000062282	DGAT2	3.025834266	1.21E-6	7.72E-5
ENSG00000128185	DGCR6L	5.121868001	7.38E-6	3.57503E-4
ENSG00000153933	DGKE	-2.299608434	2.51865E-4	0.006508303
ENSG00000058866	DGKG	-4.062399848	2.68011E-4	0.00682221
ENSG00000145214	DGKQ	2.377268844	6.93E-5	0.002303051
ENSG00000073737	DHRS9	2.944672799	1.12307E-4	0.003400457
ENSG00000089876	DHX32	2.07217147	5.37E-6	2.7508E-4
ENSG00000066084	DIP2B	1.804069437	3.11E-5	0.001185622
ENSG00000151240	DIP2C	2.209921992	2.56E-7	2.03E-5
ENSG00000176490	DIRAS1	4.733560573	4.3E-10	7.23E-8
ENSG00000130826	DKC1	1.837661687	3.73E-5	0.001374113
ENSG00000050165	DKK3	-3.149703859	1.28847E-4	0.003804817
ENSG00000080845	DLGAP4	3.822448449	2.61E-22	1.89E-19
ENSG00000104093	DMXL2	1.625423367	1.61873E-4	0.004552159
ENSG00000154099	DNAAF1	-2.412349745	3.42372E-4	0.008316315
ENSG00000164818	DNAAF5	2.368989184	2.1E-7	1.7E-5
ENSG00000174844	DNAH12	-16.23225965	4.27E-5	0.001538721
ENSG00000140403	DNAJA4	2.004309288	4.82E-5	0.001692028
ENSG00000136770	DNAJC1	2.144871445	3.04947E-4	0.007588569
ENSG00000120675	DNAJC15	2.047096059	3.3E-5	0.00124767
ENSG00000170464	DNAJC18	-2.25479111	3.1149E-4	0.007735285
ENSG00000110011	DNAJC4	2.283850567	6.57E-6	3.26079E-4
ENSG00000101152	DNAJC5	2.186592648	3.29E-7	2.56E-5
ENSG00000105612	DNASE2	2.101166141	1.28799E-4	0.003804817
ENSG00000123992	DNPEP	1.97161302	4.48E-6	2.34895E-4
ENSG00000107099	DOCK8	-1.758414735	1.52235E-4	0.004321823
ENSG00000101134	DOK5	5.067827368	6.42E-17	2.92E-14
ENSG00000142197	DOPEY2	1.794691291	1.45205E-4	0.004179361
ENSG00000000419	DPM1	2.751644855	1.28546E-4	0.00380063
ENSG00000136908	DPM2	2.364495589	2.17065E-4	0.005742611
ENSG00000179085	DPM3	2.225699023	2.49554E-4	0.006453218
ENSG00000254986	DPP3	2.296041484	1.01E-5	4.56175E-4
ENSG00000173852	DPY19L1	2.602462492	1.7E-6	1.03779E-4
ENSG00000096696	DSP	-3.81988533	1.57E-5	6.69312E-4
ENSG00000125821	DTD1	2.384744359	4.99E-7	3.64E-5
ENSG00000110042	DTX4	1.854762547	1.95E-5	8.01832E-4
ENSG00000120129	DUSP1	-2.386095604	8.36E-5	0.002679065
ENSG00000143507	DUSP10	2.837738017	4.36E-5	0.00156448
ENSG00000108861	DUSP3	1.958404155	5.17E-6	2.67428E-4
ENSG00000120875	DUSP4	2.22443325	8.32E-6	3.91434E-4
ENSG00000139318	DUSP6	2.158877929	6.88E-8	6.4E-6
ENSG00000107404	DVL1	1.893228188	1.12785E-4	0.003412769
ENSG00000161202	DVL3	1.934367683	3.17E-6	1.74866E-4
ENSG00000088986	DYNLL1	2.350293677	4.09E-8	4.08E-6
ENSG00000146425	DYNLT1	2.153852986	2.12E-7	1.71E-5
ENSG00000144597	EAF1	2.048391118	8.77E-5	0.002794816
ENSG00000103356	EARS2	1.91012122	7.81E-5	0.002533838
ENSG00000117395	EBNA1BP2	2.204483132	2.19E-6	1.28088E-4
ENSG00000121310	ECHDC2	-2.223889845	8.75E-6	4.08236E-4
ENSG00000134109	EDEM1	2.437176868	8.93E-10	1.4E-7
ENSG00000107223	EDF1	2.288389737	1.33E-7	1.13E-5
ENSG00000164176	EDIL3	2.736027329	5.38E-7	3.89E-5
ENSG00000136160	EDNRB	1.994671012	1.39136E-4	0.004051062
ENSG00000156508	EEF1A1	1.707527305	2.61925E-4	0.006699429
ENSG00000114942	EEF1B2	1.831645608	1.99178E-4	0.005351449
ENSG00000254772	EEF1G	1.815406027	2.79931E-4	0.00708038
ENSG00000090776	EFNB1	1.764106636	1.93097E-4	0.00522719
ENSG00000132294	EFR3A	1.816601276	4.66E-5	0.001654916
ENSG00000100842	EFS	2.019292712	8.34E-5	0.002675641
ENSG00000129521	EGLN3	-5.898561855	1.86708E-4	0.005085944
ENSG00000120738	EGR1	-4.54688232	4.86E-6	2.52892E-4
ENSG00000198692	EIF1AY	3.646463054	2.26E-8	2.49E-6
ENSG00000086232	EIF2AK1	1.802908756	5.07E-5	0.001764405
ENSG00000070785	EIF2B3	1.821350393	3.65453E-4	0.008747991
ENSG00000134001	EIF2S1	1.975347575	8.7E-6	4.06421E-4
ENSG00000125977	EIF2S2	2.414719894	5.68E-10	9.35E-8
ENSG00000130811	EIF3G	1.842717923	2.37E-5	9.38695E-4
ENSG00000178982	EIF3K	1.81093059	4.21755E-4	0.009783851
ENSG00000161960	EIF4A1	2.041145272	8.14E-7	5.52E-5
ENSG00000135930	EIF4E2	1.706811699	7.53E-5	0.002458692
ENSG00000110321	EIF4G2	1.954666967	7.43E-6	3.58645E-4
ENSG00000100664	EIF5	1.942028889	3.37E-5	0.001263111
ENSG00000132507	EIF5A	2.130551197	1.56E-6	9.54E-5
ENSG00000242372	EIF6	2.212795508	3.08E-6	1.70988E-4
ENSG00000062598	ELMO2	1.707681714	3.91E-5	0.001432601
ENSG00000066322	ELOVL1	2.086231586	2.33E-6	1.3412E-4
ENSG00000125037	EMC3	1.540309526	4.20901E-4	0.009775369
ENSG00000131148	EMC8	2.112348474	2.16E-5	8.72117E-4
ENSG00000102119	EMD	1.855540586	3.84764E-4	0.009079921
ENSG00000126749	EMG1	2.053518341	1.11E-5	4.98885E-4
ENSG00000143924	EML4	1.852417956	8.85E-5	0.002814243
ENSG00000134531	EMP1	-2.022650513	1.10235E-4	0.003350448
ENSG00000229847	EMX2OS	2.06683226	1.42E-5	6.14465E-4
ENSG00000154380	ENAH	2.008011132	2.54E-6	1.45247E-4
ENSG00000074800	ENO1	3.056862897	2.62E-15	9.79E-13
ENSG00000145293	ENOPH1	2.665571171	6.08E-6	3.05931E-4
ENSG00000187097	ENTPD5	2.079826054	2.24E-8	2.48E-6
ENSG00000082397	EPB41L3	3.075556662	1.44E-15	5.6E-13
ENSG00000182580	EPHB3	3.78762806	1.41867E-4	0.004105537
ENSG00000143819	EPHX1	3.305127227	7.97E-13	2.04E-10
ENSG00000136628	EPRS	2.56591887	2.42E-13	6.66E-11
ENSG00000133106	EPSTI1	2.14030966	4.25154E-4	0.009832245
ENSG00000132591	ERAL1	1.945531743	2.11E-5	8.57171E-4
ENSG00000164308	ERAP2	2.568068485	7.04E-8	6.51E-6
ENSG00000178568	ERBB4	-7.715994722	4.76E-5	0.001676184
ENSG00000113719	ERGIC1	1.748843746	1.29E-5	5.6226E-4
ENSG00000100632	ERH	2.441840331	2.58992E-4	0.006642175
ENSG00000204334	ERICH2	16.93199031	2.9E-19	1.77E-16
ENSG00000089248	ERP29	1.703854685	3.90566E-4	0.00919254
ENSG00000213462	ERV3-1	3.23477061	1.68E-14	5.66E-12
ENSG00000140009	ESR2	-2.428924779	1.97E-5	8.08443E-4
ENSG00000120705	ETF1	1.781867635	2.17325E-4	0.005746316
ENSG00000244405	ETV5	4.163559421	9.39E-14	2.85E-11
ENSG00000142694	EVA1B	3.307284694	5.59E-5	0.001911584
ENSG00000072840	EVC	1.893708234	3.93E-5	0.001437303
ENSG00000077348	EXOSC5	6.165913251	3.02E-8	3.17E-6
ENSG00000110723	EXPH5	-2.141192852	1.85128E-4	0.005059953
ENSG00000124491	F13A1	3.569645721	5.01E-16	2.12E-13
ENSG00000127533	F2RL3	-2.749983467	4.6E-5	0.001637086
ENSG00000198734	F5	-4.445319282	3.51E-5	0.001305932
ENSG00000185010	F8	-2.998370878	1.49E-5	6.39167E-4
ENSG00000221968	FADS3	3.368877568	6.19E-20	3.95E-17
ENSG00000167106	FAM102A	2.232536592	3.13E-6	1.72885E-4
ENSG00000138439	FAM117B	-2.16889001	1.26E-5	5.51707E-4
ENSG00000188938	FAM120AOS	1.895706631	4.76E-5	0.001676184
ENSG00000124019	FAM124B	-3.879325103	9.98E-6	4.53629E-4
ENSG00000155744	FAM126B	-2.614553487	3.09E-5	0.001180236
ENSG00000203950	FAM127B	2.586057723	1.06E-9	1.64E-7
ENSG00000135842	FAM129A	3.765388174	4.88E-24	4.48E-21
ENSG00000114023	FAM162A	1.821425937	3.29046E-4	0.008083017
ENSG00000188163	FAM166A	1.923776144	1.58168E-4	0.004461094
ENSG00000144369	FAM171B	2.472403129	1.05E-7	9.33E-6
ENSG00000103254	FAM173A	3.119210835	2.87384E-4	0.0072306
ENSG00000219438	FAM19A5	2.81702247	1.87447E-4	0.005100235
ENSG00000173065	FAM222B	1.818143985	2.13E-6	1.25079E-4
ENSG00000119979	FAM45A	2.124017518	2.42E-10	4.3E-8
ENSG00000189157	FAM47E	-2.238890689	8.19E-6	3.86205E-4
ENSG00000197872	FAM49A	3.040376777	7.53E-11	1.47E-8
ENSG00000182118	FAM89A	1.864843805	2.09783E-4	0.005587083
ENSG00000112039	FANCE	3.49162585	2.14E-9	3.1E-7
ENSG00000064763	FAR2	2.371906671	3.82E-7	2.89E-5
ENSG00000179115	FARSA	2.925323824	6.21E-8	5.87E-6
ENSG00000116120	FARSB	2.385821187	6.42E-8	6.01E-6
ENSG00000026103	FAS	2.373675782	1.51198E-4	0.004307753
ENSG00000164896	FASTK	2.317131033	3.51E-5	0.001305932
ENSG00000165323	FAT3	-2.702294212	6.0E-7	4.28E-5
ENSG00000149806	FAU	2.025485156	1.17E-5	5.22521E-4
ENSG00000147912	FBXO10	2.291830354	2.67E-6	1.50732E-4
ENSG00000143756	FBXO28	2.489146915	4.15E-6	2.20949E-4
ENSG00000164117	FBXO8	2.310094681	1.49059E-4	0.004264599
ENSG00000072803	FBXW11	2.011987471	1.25E-5	5.48875E-4
ENSG00000159069	FBXW5	2.412818287	3.12E-6	1.72841E-4
ENSG00000158869	FCER1G	2.803416024	5.36E-8	5.17E-6
ENSG00000143226	FCGR2A	2.394178772	2.06E-7	1.67E-5
ENSG00000066926	FECH	2.425901412	1.32E-7	1.13E-5
ENSG00000149781	FERMT3	3.310421387	8.07E-9	9.98E-7
ENSG00000180263	FGD6	1.713298021	3.59024E-4	0.00861552
ENSG00000113578	FGF1	3.843285855	1.93E-18	1.1E-15
ENSG00000066468	FGFR2	2.018348802	1.42E-5	6.13787E-4
ENSG00000091483	FH	2.062484281	2.99E-5	0.001143438
ENSG00000022267	FHL1	-2.764298763	1.88E-7	1.55E-5
ENSG00000112214	FHL5	-4.112395517	1.2E-5	5.32838E-4
ENSG00000172500	FIBP	2.101416446	1.36E-6	8.54E-5
ENSG00000198855	FICD	2.356443082	3.31149E-4	0.008117992
ENSG00000112367	FIG4	1.980913754	1.89595E-4	0.005149891
ENSG00000118407	FILIP1	-3.639121533	7.27E-7	5.04E-5
ENSG00000214253	FIS1	1.839753543	4.84E-5	0.001698821
ENSG00000106080	FKBP14	1.601007135	3.96009E-4	0.009288341
ENSG00000088832	FKBP1A	1.804844132	4.51E-5	0.001613264
ENSG00000173486	FKBP2	2.013506601	5.04E-7	3.66E-5
ENSG00000100442	FKBP3	1.754874757	9.11E-5	0.002876786
ENSG00000004478	FKBP4	1.860506035	1.71074E-4	0.004753283
ENSG00000096060	FKBP5	-3.763612767	2.28E-5	9.10148E-4
ENSG00000196924	FLNA	1.927949164	2.31E-5	9.21142E-4
ENSG00000128591	FLNC	6.276613394	2.95E-36	5.22E-33
ENSG00000137312	FLOT1	1.852727969	3.98E-5	0.00145083
ENSG00000126500	FLRT1	4.141758055	4.8E-5	0.00169047
ENSG00000162076	FLYWCH2	2.452712968	1.85828E-4	0.005070644
ENSG00000010932	FMO1	2.928559065	2.49E-8	2.7E-6
ENSG00000164694	FNDC1	-9.336997712	4.86E-6	2.52892E-4
ENSG00000115226	FNDC4	3.119836726	2.1E-8	2.34E-6
ENSG00000165457	FOLR2	2.340469751	7.6E-5	0.002474989
ENSG00000170345	FOS	-5.091771182	1.15E-6	7.4E-5
ENSG00000125740	FOSB	-9.639509404	2.81E-8	2.98E-6
ENSG00000187474	FPR3	4.311501692	2.22E-11	4.57E-9
ENSG00000153303	FRMD1	-5.221205608	1.25E-5	5.49503E-4
ENSG00000075618	FSCN1	2.785881256	5.57E-7	4.0E-5
ENSG00000134363	FST	2.19164374	7.72E-5	0.002508181
ENSG00000070404	FSTL3	2.046384347	5.0E-5	0.001745988
ENSG00000167996	FTH1	3.798428914	1.39E-22	1.06E-19
ENSG00000087086	FTL	5.285027137	1.44E-36	2.75E-33
ENSG00000122687	FTSJ2	1.746787601	3.34857E-4	0.008175331
ENSG00000001036	FUCA2	2.146964856	1.93E-5	7.97703E-4
ENSG00000148803	FUOM	4.16032302	1.6E-6	9.76E-5
ENSG00000082074	FYB	1.88538421	4.24671E-4	0.009825829
ENSG00000122068	FYTTD1	2.018258857	1.55E-5	6.61257E-4
ENSG00000123689	G0S2	3.48658869	2.36E-8	2.58E-6
ENSG00000141349	G6PC3	1.873207079	1.27971E-4	0.003788319
ENSG00000171298	GAA	2.043217224	1.47454E-4	0.00423134
ENSG00000033327	GAB2	2.422618352	1.81E-9	2.67E-7
ENSG00000170296	GABARAP	2.238891709	3.94E-6	2.10674E-4
ENSG00000204681	GABBR1	-1.972953574	1.20752E-4	0.003605879
ENSG00000144278	GALNT13	2.882960377	5.98E-10	9.82E-8
ENSG00000131386	GALNT15	-4.656857268	1.61E-11	3.41E-9
ENSG00000089597	GANAB	1.767154989	1.41361E-4	0.004093376
ENSG00000111640	GAPDH	3.186609194	1.81E-12	4.43E-10
ENSG00000106105	GARS	6.056976097	2.49E-61	1.48E-57
ENSG00000234741	GAS5	1.93211265	3.34E-7	2.59E-5
ENSG00000167491	GATAD2A	2.220481804	2.77E-8	2.96E-6
ENSG00000177628	GBA	2.182903187	1.11E-6	7.14E-5
ENSG00000114480	GBE1	3.118537688	9.2E-12	2.05E-9
ENSG00000117228	GBP1	1.818511556	1.07713E-4	0.003286354
ENSG00000179562	GCC1	1.877529801	1.03892E-4	0.003190856
ENSG00000023909	GCLM	2.30537568	2.19E-11	4.54E-9
ENSG00000111846	GCNT2	-3.30376469	1.97181E-4	0.00530768
ENSG00000140905	GCSH	2.44975161	1.16485E-4	0.003504273
ENSG00000006007	GDE1	2.253402149	2.66E-8	2.86E-6
ENSG00000130513	GDF15	13.28791926	7.46E-24	6.6E-21
ENSG00000164949	GEM	2.474009312	4.68E-5	0.00166177
ENSG00000198380	GFPT1	2.219538083	4.32E-10	7.24E-8
ENSG00000165678	GHITM	2.141797876	6.75E-5	0.002254684
ENSG00000141034	GID4	1.781848161	6.69E-5	0.002239014
ENSG00000145723	GIN1	2.47378571	4.23676E-4	0.009812317
ENSG00000165474	GJB2	5.76754393	2.77E-10	4.89E-8
ENSG00000170266	GLB1	2.34165636	6.7E-9	8.42E-7
ENSG00000126603	GLIS2	4.054766679	9.67E-16	4.02E-13
ENSG00000023572	GLRX2	3.240475362	9.21E-5	0.002891744
ENSG00000135821	GLUL	-4.347039552	9.04E-7	6.01E-5
ENSG00000149124	GLYAT	-4.949249002	1.71E-8	1.95E-6
ENSG00000196743	GM2A	2.43285161	2.65E-9	3.76E-7
ENSG00000197045	GMFB	2.215714919	1.33E-5	5.76701E-4
ENSG00000146535	GNA12	1.98217234	8.71E-7	5.83E-5
ENSG00000120063	GNA13	1.826274036	4.34E-5	0.001558325
ENSG00000078369	GNB1	1.900623907	5.06E-5	0.001762852
ENSG00000204628	GNB2L1	1.72101814	3.84831E-4	0.009079921
ENSG00000172380	GNG12	1.957160593	5.45E-6	2.79322E-4
ENSG00000186469	GNG2	2.457536985	5.62E-9	7.24E-7
ENSG00000174021	GNG5	2.439148836	1.17E-6	7.49E-5
ENSG00000163938	GNL3	3.404895471	4.05E-19	2.42E-16
ENSG00000113552	GNPDA1	2.374918971	4.12E-7	3.08E-5
ENSG00000115806	GORASP2	1.776379164	1.03716E-4	0.003188828
ENSG00000120053	GOT1	2.89782322	2.4E-7	1.91E-5
ENSG00000197858	GPAA1	3.459174673	1.32E-13	3.81E-11
ENSG00000063660	GPC1	5.108103549	3.77E-22	2.69E-19
ENSG00000147257	GPC3	-2.31387563	2.32E-5	9.23207E-4
ENSG00000076716	GPC4	3.410646904	3.34E-9	4.61E-7
ENSG00000154478	GPR26	-27.75254306	1.21398E-4	0.003613868
ENSG00000135898	GPR55	-38.65596363	1.86485E-4	0.005082757
ENSG00000140030	GPR65	5.369812216	1.93E-5	7.97703E-4
ENSG00000132522	GPS2	1.901554544	6.11E-6	3.06733E-4
ENSG00000178719	GRINA	2.173869303	3.12E-5	0.00118852
ENSG00000030582	GRN	2.003425261	2.38E-5	9.43166E-4
ENSG00000109519	GRPEL1	1.860988282	6.38E-6	3.18668E-4
ENSG00000164284	GRPEL2	2.164173435	9.13E-6	4.23732E-4
ENSG00000073605	GSDMB	-2.658054826	2.84E-5	0.001096585
ENSG00000082701	GSK3B	1.940369405	3.42E-6	1.87554E-4
ENSG00000103342	GSPT1	1.972723054	6.98E-6	3.4058E-4
ENSG00000100983	GSS	2.434503063	3.91E-8	3.93E-6
ENSG00000134202	GSTM3	2.024144276	1.15E-5	5.16027E-4
ENSG00000168765	GSTM4	1.802061381	1.63878E-4	0.004600427
ENSG00000134201	GSTM5	2.028449515	3.17E-5	0.001202475
ENSG00000084207	GSTP1	2.28464163	1.2E-5	5.32192E-4
ENSG00000155115	GTF3C6	2.799263532	1.18E-8	1.4E-6
ENSG00000172432	GTPBP2	2.667844959	2.33E-9	3.36E-7
ENSG00000151806	GUF1	2.039283538	1.58E-5	6.72356E-4
ENSG00000143774	GUK1	2.014075858	6.48E-6	3.22495E-4
ENSG00000144366	GULP1	2.1639778	7.84E-8	7.18E-6
ENSG00000172986	GXYLT2	2.831807812	6.82E-8	6.35E-6
ENSG00000056998	GYG2	-2.189806008	2.36534E-4	0.006168851
ENSG00000104812	GYS1	2.275933373	1.35E-6	8.47E-5
ENSG00000189060	H1F0	2.02074368	2.72E-7	2.15E-5
ENSG00000164032	H2AFZ	3.123771724	2.18E-13	6.08E-11
ENSG00000130956	HABP4	2.468366606	4.26E-9	5.62E-7
ENSG00000074696	HACD3	1.932602873	1.15E-8	1.37E-6
ENSG00000138029	HADHB	1.976442261	1.05E-5	4.74589E-4
ENSG00000143575	HAX1	2.5707045	3.64E-9	4.93E-7
ENSG00000103145	HCFC1R1	2.304724011	3.28585E-4	0.008077271
ENSG00000126264	HCST	4.760635574	2.04E-6	1.20992E-4
ENSG00000196591	HDAC2	1.70350265	2.31039E-4	0.006048667
ENSG00000213614	HEXA	1.607820921	4.04694E-4	0.009445953
ENSG00000100644	HIF1A	2.211973937	8.39E-10	1.34E-7
ENSG00000181061	HIGD1A	1.82114832	3.39864E-4	0.008268006
ENSG00000146066	HIGD2A	2.220562533	2.11E-6	1.24602E-4
ENSG00000169567	HINT1	2.403512653	3.0E-8	3.16E-6
ENSG00000168298	HIST1H1E	2.10495648	3.56E-5	0.001321396
ENSG00000180596	HIST1H2BC	2.152398621	1.34265E-4	0.003935606
ENSG00000197903	HIST1H2BK	2.103531184	2.93529E-4	0.007365825
ENSG00000156515	HK1	2.066048691	3.13E-8	3.25E-6
ENSG00000206503	HLA-A	2.019157591	3.95266E-4	0.009280303
ENSG00000204632	HLA-G	-5.308613241	2.06178E-4	0.005521851
ENSG00000159267	HLCS	2.826212314	4.65E-14	1.5E-11
ENSG00000071794	HLTF	1.955368563	1.5777E-4	0.004452496
ENSG00000147421	HMBOX1	1.722881809	4.86E-5	0.001700894
ENSG00000256269	HMBS	3.109737736	5.15E-5	0.001787899
ENSG00000137309	HMGA1	3.393312989	5.43E-13	1.43E-10
ENSG00000112972	HMGCS1	2.518159484	2.97E-11	6.04E-9
ENSG00000205581	HMGN1	1.767773394	4.23461E-4	0.009812317
ENSG00000100292	HMOX1	4.313330195	1.0E-10	1.9E-8
ENSG00000189159	HN1	2.672790706	5.41E-5	0.001857259
ENSG00000177733	HNRNPA0	1.906111176	1.63E-5	6.90038E-4
ENSG00000197451	HNRNPAB	2.027794488	1.89E-5	7.84442E-4
ENSG00000165119	HNRNPK	1.938013691	4.19E-5	0.001515242
ENSG00000241935	HOGA1	-2.819109751	3.58586E-4	0.00861276
ENSG00000233429	HOTAIRM1	3.03889784	3.58E-5	0.001327258
ENSG00000253293	HOXA10	-5.056288871	2.96E-5	0.001131382
ENSG00000106006	HOXA6	-8.438413739	4.96E-5	0.001731446
ENSG00000122592	HOXA7	-8.18523805	1.26E-11	2.71E-9
ENSG00000120075	HOXB5	3.012751485	9.93E-5	0.003078117
ENSG00000163106	HPGDS	2.848612649	5.84E-6	2.95761E-4
ENSG00000107521	HPS1	2.315625051	1.1E-6	7.14E-5
ENSG00000174775	HRAS	2.527511408	5.29E-6	2.71875E-4
ENSG00000153936	HS2ST1	2.896665276	9.98E-9	1.19E-6
ENSG00000136720	HS6ST1	2.685689174	4.3E-8	4.27E-6
ENSG00000176387	HSD11B2	4.705744504	7.48E-6	3.60282E-4
ENSG00000096384	HSP90AB1	1.692209783	2.8089E-4	0.007097104
ENSG00000155304	HSPA13	2.024943787	1.77351E-4	0.004895233
ENSG00000126803	HSPA2	2.229274968	3.42726E-4	0.008320694
ENSG00000170606	HSPA4	2.2172753	3.02E-9	4.23E-7
ENSG00000044574	HSPA5	5.026324181	1.88E-36	3.45E-33
ENSG00000109971	HSPA8	3.070174806	6.58E-14	2.03E-11
ENSG00000113013	HSPA9	4.461222073	8.59E-33	1.28E-29
ENSG00000004776	HSPB6	2.11733522	2.19E-6	1.28088E-4
ENSG00000152137	HSPB8	1.841133105	4.02386E-4	0.009396669
ENSG00000144381	HSPD1	1.847182313	3.73599E-4	0.008902842
ENSG00000115541	HSPE1	1.96029366	4.56E-5	0.001625556
ENSG00000120694	HSPH1	2.553350566	5.26E-9	6.83E-7
ENSG00000109854	HTATIP2	2.900974983	9.78E-7	6.41E-5
ENSG00000114378	HYAL1	-4.372806628	3.92E-5	0.001433422
ENSG00000149428	HYOU1	2.018527524	1.3E-5	5.65421E-4
ENSG00000196305	IARS	3.620564785	2.21E-20	1.43E-17
ENSG00000116237	ICMT	1.90922259	3.58E-6	1.94199E-4
ENSG00000167862	ICT1	2.289896589	9.0E-8	8.16E-6
ENSG00000172201	ID4	-7.169509752	1.04049E-4	0.003190856
ENSG00000119632	IFI27L2	3.156825035	1.36E-7	1.16E-5
ENSG00000216490	IFI30	3.983879724	8.74E-22	6.05E-19
ENSG00000214706	IFRD2	2.520685786	8.13E-5	0.002620878
ENSG00000146674	IGFBP3	2.194905946	1.22E-5	5.38819E-4
ENSG00000141753	IGFBP4	2.6776962	1.62E-9	2.4E-7
ENSG00000167779	IGFBP6	-3.207186152	6.31E-5	0.002126824
ENSG00000140749	IGSF6	2.948179232	6.94E-9	8.7E-7
ENSG00000162729	IGSF8	2.245184363	2.48E-8	2.69E-6
ENSG00000110324	IL10RA	3.412820408	2.35E-9	3.39E-7
ENSG00000137070	IL11RA	2.108023936	8.1E-6	3.82681E-4
ENSG00000136689	IL1RN	7.980623597	1.54E-17	7.68E-15
ENSG00000174564	IL20RB	8.328531033	3.47E-42	9.21E-39
ENSG00000143621	ILF2	2.100280075	1.94E-5	7.97703E-4
ENSG00000132305	IMMT	1.693063949	3.69026E-4	0.008820251
ENSG00000136718	IMP4	1.781932588	1.29E-5	5.62382E-4
ENSG00000178035	IMPDH2	2.245247958	9.4E-6	4.32643E-4
ENSG00000259330	INAFM2	6.461569178	7.08E-18	3.68E-15
ENSG00000109452	INPP4B	-2.421850212	3.39E-5	0.001269612
ENSG00000161896	IP6K3	10.88182733	4.26E-33	6.78E-30
ENSG00000196497	IPO4	2.962540828	7.69E-14	2.36E-11
ENSG00000205339	IPO7	1.861653584	1.64912E-4	0.004621312
ENSG00000184216	IRAK1	3.101836475	8.05E-12	1.81E-9
ENSG00000140968	IRF8	1.919559472	1.30843E-4	0.003856592
ENSG00000159387	IRX6	-7.180986006	6.35E-8	5.97E-6
ENSG00000129009	ISLR	1.871466555	4.3069E-4	0.009931438
ENSG00000261796	ISY1-RAB43	8.976785791	8.85E-9	1.07E-6
ENSG00000077943	ITGA8	2.405691216	6.3E-9	7.98E-7
ENSG00000138448	ITGAV	2.667308478	3.79E-9	5.08E-7
ENSG00000160255	ITGB2	3.386886381	9.31E-12	2.07E-9
ENSG00000102313	ITIH6	-11.77033011	8.34E-5	0.002675275
ENSG00000125877	ITPA	2.014527566	2.83E-5	0.001094382
ENSG00000128928	IVD	1.552357234	3.94393E-4	0.009268924
ENSG00000161999	JMJD8	1.977619747	8.79E-6	4.09608E-4
ENSG00000143543	JTB	1.934322298	9.99E-5	0.003093346
ENSG00000171223	JUNB	-3.788250918	6.94E-6	3.39358E-4
ENSG00000107821	KAZALD1	3.996848463	5.77E-8	5.49E-6
ENSG00000189337	KAZN	2.288560495	3.06E-8	3.21E-6
ENSG00000176407	KCMF1	2.290685248	5.69E-7	4.08E-5
ENSG00000171385	KCND3	2.783233296	1.85E-10	3.34E-8
ENSG00000026559	KCNG1	26.47177593	3.14E-23	2.54E-20
ENSG00000124249	KCNK15	4.452955875	9.48E-6	4.35786E-4
ENSG00000082482	KCNK2	-5.389516699	3.21301E-4	0.007941771
ENSG00000156113	KCNMA1	2.582815176	5.49E-5	0.001884299
ENSG00000134504	KCTD1	3.486824529	5.96E-14	1.9E-11
ENSG00000174943	KCTD13	2.664660931	2.56E-9	3.66E-7
ENSG00000153885	KCTD15	1.976944467	8.86E-5	0.002817833
ENSG00000165097	KDM1B	2.357223365	1.91E-9	2.8E-7
ENSG00000012817	KDM5D	24.08420217	3.52E-78	3.37E-74
ENSG00000079999	KEAP1	2.289417532	1.61E-7	1.35E-5
ENSG00000007202	KIAA0100	1.749708734	3.53888E-4	0.008518092
ENSG00000170871	KIAA0232	1.853642944	9.39E-5	0.002939141
ENSG00000100364	KIAA0930	2.810480985	7.25E-13	1.88E-10
ENSG00000122203	KIAA1191	1.840045656	9.28E-6	4.2847E-4
ENSG00000130518	KIAA1683	-3.849557933	1.17E-7	1.02E-5
ENSG00000130294	KIF1A	10.5311001	6.46E-14	2.01E-11
ENSG00000139116	KIF21A	2.032243467	1.3065E-4	0.003853293
ENSG00000101350	KIF3B	2.050807842	1.32E-7	1.13E-5
ENSG00000170759	KIF5B	2.78201551	2.83E-10	4.97E-8
ENSG00000166813	KIF7	4.49573459	5.64E-14	1.81E-11
ENSG00000140859	KIFC3	1.688653313	1.96787E-4	0.005300041
ENSG00000157404	KIT	2.275393987	1.22E-6	7.77E-5
ENSG00000127528	KLF2	-3.803581768	8.5E-7	5.72E-5
ENSG00000136826	KLF4	-4.377274604	1.07E-8	1.27E-6
ENSG00000102349	KLF8	-1.842767197	2.95956E-4	0.007411152
ENSG00000130487	KLHDC7B	11.50423763	9.87E-19	5.82E-16
ENSG00000185909	KLHDC8B	1.872777573	3.81404E-4	0.009030269
ENSG00000178502	KLHL11	2.045974286	4.0579E-4	0.009466914
ENSG00000114648	KLHL18	1.940501595	8.53E-5	0.002723246
ENSG00000087448	KLHL42	1.763115917	3.22307E-4	0.007958401
ENSG00000109790	KLHL5	2.030243645	5.71E-7	4.09E-5
ENSG00000134539	KLRD1	-2.47101688	4.00528E-4	0.009367014
ENSG00000128944	KNSTRN	2.756863333	2.2E-6	1.28088E-4
ENSG00000114030	KPNA1	1.758516194	7.41E-6	3.5852E-4
ENSG00000163463	KRTCAP2	1.731864263	1.25051E-4	0.003711057
ENSG00000103642	LACTB	2.130076868	5.11E-5	0.001776082
ENSG00000196976	LAGE3	2.882732901	7.36E-6	3.57048E-4
ENSG00000167613	LAIR1	2.287504644	2.44E-5	9.60494E-4
ENSG00000196569	LAMA2	-2.773924353	1.29E-7	1.11E-5
ENSG00000091128	LAMB4	-3.222799293	1.05794E-4	0.003233995
ENSG00000005893	LAMP2	1.684015475	1.19E-5	5.27343E-4
ENSG00000188186	LAMTOR4	1.886306653	2.11381E-4	0.005620247
ENSG00000162511	LAPTM5	2.180837502	3.41E-7	2.62E-5
ENSG00000166173	LARP6	2.662521503	3.84E-7	2.9E-5
ENSG00000002834	LASP1	1.746907326	2.60121E-4	0.006660659
ENSG00000162194	LBHD1	1.75963229	2.57349E-4	0.006610696
ENSG00000136167	LCP1	3.986607675	3.4E-17	1.61E-14
ENSG00000122367	LDB3	-2.469072571	1.93473E-4	0.005234408
ENSG00000179241	LDLRAD3	2.260430422	7.08E-7	4.93E-5
ENSG00000267690	LDLRAD4-AS1	-8.663388361	3.96192E-4	0.009288341
ENSG00000166477	LEO1	1.648045549	3.68963E-4	0.008820251
ENSG00000174697	LEP	-4.628821445	2.7E-10	4.77E-8
ENSG00000168924	LETM1	1.676545967	1.47374E-4	0.00423134
ENSG00000106003	LFNG	2.606423838	2.47E-7	1.97E-5
ENSG00000168961	LGALS9	2.288006363	2.38E-5	9.43166E-4
ENSG00000100600	LGMN	2.313868217	8.1E-9	9.99E-7
ENSG00000145685	LHFPL2	2.490587441	4.95E-12	1.15E-9
ENSG00000121897	LIAS	1.892064285	1.79185E-4	0.004931605
ENSG00000050405	LIMA1	1.726500309	3.09761E-4	0.007696346
ENSG00000064042	LIMCH1	-3.485985615	6.06E-9	7.75E-7
ENSG00000169756	LIMS1	1.666116879	4.03E-5	0.001462164
ENSG00000231721	LINC-PINT	-2.262126282	4.05E-6	2.15537E-4
ENSG00000236871	LINC00106	-4.102356235	3.33637E-4	0.008157128
ENSG00000231535	LINC00278	34.79211443	6.06E-10	9.92E-8
ENSG00000225016	LINC00328-2P	-5.82476333	7.76E-7	5.3E-5
ENSG00000235532	LINC00402	-5.006343091	1.70421E-4	0.004739556
ENSG00000232388	LINC00493	2.428639942	5.61E-5	0.001916627
ENSG00000245060	LINC00847	2.7653718	8.71E-8	7.94E-6
ENSG00000260102	LINC01070	-12.79782191	4.01843E-4	0.009388596
ENSG00000175772	LINC01106	-6.920404444	2.19443E-4	0.005795902
ENSG00000228794	LINC01128	2.109041678	9.83E-8	8.83E-6
ENSG00000224259	LINC01133	-9.157562763	6.41E-6	3.19642E-4
ENSG00000236423	LINC01134	-4.340148606	1.95848E-4	0.005286692
ENSG00000234840	LINC01239	1.918940093	1.56531E-4	0.004425383
ENSG00000107798	LIPA	2.028249377	3.16E-5	0.00120085
ENSG00000189067	LITAF	2.909582084	1.44E-15	5.6E-13
ENSG00000071282	LMCD1	-3.197944488	7.57E-11	1.47E-8
ENSG00000143013	LMO4	1.826302016	2.74852E-4	0.006966654
ENSG00000170807	LMOD2	-11.33922056	3.40596E-4	0.008281593
ENSG00000162761	LMX1A	-6.893885953	5.23E-5	0.001807763
ENSG00000250930	LNX1-AS1	-13.21374804	9.39E-6	4.32456E-4
ENSG00000262094	LOC100505909	-12.37261297	3.732E-4	0.008898353
ENSG00000254814	LOC100506113	3.145173262	1.53E-6	9.41E-5
ENSG00000263470	LOC100507002	4.708109839	2.06762E-4	0.005531284
ENSG00000249717	LOC100507388	-5.577709243	2.1E-6	1.23934E-4
ENSG00000253123	LOC100507403	-10.99969483	3.34445E-4	0.008169462
ENSG00000237807	LOC100507516	2.813921971	6.88E-5	0.002287495
ENSG00000231683	LOC101927136	-4.336697082	5.94E-5	0.002024286
ENSG00000225057	LOC101927958	-9.836925291	7.27E-5	0.002392141
ENSG00000236252	LOC101928381	-2.922583032	1.5332E-4	0.004344873
ENSG00000227591	LOC101930114	-2.643028973	6.44E-5	0.00216741
ENSG00000142178	LOC102724428/SIK1	-3.597217185	4.75E-5	0.001676184
ENSG00000232233	LOC102724699	-8.092007838	6.59E-5	0.002213338
ENSG00000225929	LOC105373100	-45.29544144	3.50083E-4	0.008465741
ENSG00000228436	LOC105378663	4.643910602	3.03E-10	5.31E-8
ENSG00000179859	LOC284023	-2.709375013	2.6634E-4	0.006788956
ENSG00000188897	LOC400499	-8.05133642	6.65E-6	3.28053E-4
ENSG00000146722	LOC541473	-10.99222475	3.35492E-4	0.008182476
ENSG00000255258	LOC646522	-13.34149993	7.51E-5	0.002455636
ENSG00000196365	LONP1	3.8172801	1.9E-23	1.59E-20
ENSG00000198121	LPAR1	1.804882567	1.78158E-4	0.004911828
ENSG00000111684	LPCAT3	2.020059558	3.51E-6	1.91296E-4
ENSG00000176454	LPCAT4	-3.261198972	4.49E-7	3.31E-5
ENSG00000101577	LPIN2	1.907682979	1.69E-5	7.1174E-4
ENSG00000165379	LRFN5	2.255578412	2.90175E-4	0.007296978
ENSG00000070018	LRP6	1.809549016	1.03576E-4	0.00318686
ENSG00000157193	LRP8	2.721539475	7.04E-8	6.51E-6
ENSG00000108829	LRRC59	2.668446237	5.05E-8	4.91E-6
ENSG00000171492	LRRC8D	2.560112524	1.17E-7	1.02E-5
ENSG00000177363	LRRN4CL	3.53870084	1.03E-11	2.26E-9
ENSG00000175324	LSM1	2.235988931	5.22E-5	0.001807365
ENSG00000161654	LSM12	1.687855192	4.21832E-4	0.009783851
ENSG00000170860	LSM3	1.832259173	5.6E-5	0.001913822
ENSG00000130520	LSM4	2.979606456	3.18E-8	3.29E-6
ENSG00000012223	LTF	3.247428821	2.62657E-4	0.006714548
ENSG00000153714	LURAP1L	2.405372056	1.05599E-4	0.003230104
ENSG00000160932	LY6E	2.846022784	3.64E-10	6.21E-8
ENSG00000180155	LYNX1	1.892247552	2.90819E-4	0.007305484
ENSG00000090382	LYZ	3.55065543	1.72E-10	3.14E-8
ENSG00000107816	LZTS2	1.953109822	1.3E-5	5.63622E-4
ENSG00000183742	MACC1	-4.434284738	2.23696E-4	0.005888702
ENSG00000133315	MACROD1	3.071234267	6.49E-5	0.002180883
ENSG00000178573	MAF	2.151544494	1.05E-6	6.81E-5
ENSG00000197063	MAFG	2.442490675	3.54E-9	4.83E-7
ENSG00000102316	MAGED2	2.017525353	4.47E-6	2.34895E-4
ENSG00000147676	MAL2	2.775649842	6.24E-5	0.002108612
ENSG00000156928	MALSU1	2.404709972	2.16E-6	1.26395E-4
ENSG00000131711	MAP1B	2.359353139	3.91E-9	5.21E-7
ENSG00000034152	MAP2K3	2.355675584	6.86E-7	4.81E-5
ENSG00000095015	MAP3K1	1.806217391	3.76465E-4	0.008948815
ENSG00000071054	MAP4K4	1.808958829	8.48E-5	0.002710032
ENSG00000109339	MAPK10	1.922369694	2.4786E-4	0.006422192
ENSG00000008735	MAPK8IP2	4.121188476	7.35E-13	1.9E-10
ENSG00000162889	MAPKAPK2	2.516895614	7.72E-9	9.63E-7
ENSG00000084764	MAPRE3	2.458213617	9.43E-10	1.46E-7
ENSG00000186868	MAPT	1.74303238	7.52E-6	3.61921E-4
ENSG00000175130	MARCKSL1	2.43799535	2.70306E-4	0.006866014
ENSG00000116141	MARK1	1.689055798	7.15E-5	0.002362533
ENSG00000166986	MARS	2.188400726	5.81E-9	7.44E-7
ENSG00000155254	MARVELD1	2.239999095	2.88E-5	0.001108335
ENSG00000168906	MAT2A	2.156512261	1.3E-7	1.11E-5
ENSG00000132561	MATN2	1.870538769	1.99E-5	8.14444E-4
ENSG00000071655	MBD3	2.315758428	8.13E-5	0.002620878
ENSG00000129071	MBD4	1.952341885	2.46E-6	1.41138E-4
ENSG00000197971	MBP	2.001386507	2.3E-5	9.16506E-4
ENSG00000076706	MCAM	1.784946321	5.2E-5	0.001803994
ENSG00000055732	MCOLN3	-4.181304438	1.47E-11	3.13E-9
ENSG00000050393	MCUR1	2.293463103	3.11E-8	3.24E-6
ENSG00000146701	MDH2	2.411878266	5.81E-7	4.15E-5
ENSG00000065833	ME1	3.026320957	9.33E-7	6.16E-5
ENSG00000082212	ME2	3.166699455	2.52E-13	6.85E-11
ENSG00000085276	MECOM	-2.180807037	3.06E-6	1.69569E-4
ENSG00000116353	MECR	3.436859057	1.07E-15	4.38E-13
ENSG00000099917	MED15	1.812470779	2.56871E-4	0.006601946
ENSG00000175221	MED16	1.975503028	1.51349E-4	0.004308437
ENSG00000124641	MED20	2.024329215	3.55E-5	0.001319104
ENSG00000162591	MEGF6	-5.050969589	6.73E-5	0.002251539
ENSG00000105429	MEGF8	1.75085446	3.29514E-4	0.008090375
ENSG00000106780	MEGF9	2.956515121	1.01E-9	1.56E-7
ENSG00000111142	METAP2	1.863611469	5.6E-6	2.85707E-4
ENSG00000181038	METTL23	2.192716952	1.78751E-4	0.004925354
ENSG00000166482	MFAP4	2.549081861	7.44E-7	5.13E-5
ENSG00000197614	MFAP5	-3.6494618	1.11545E-4	0.0033838
ENSG00000148110	MFSD14B	2.157223738	2.3E-6	1.32676E-4
ENSG00000167700	MFSD3	2.864215302	1.68478E-4	0.004702388
ENSG00000182544	MFSD5	2.837590613	8.82E-8	8.02E-6
ENSG00000131446	MGAT1	1.743317601	1.55E-5	6.61432E-4
ENSG00000161013	MGAT4B	2.17953864	7.08E-5	0.00234379
ENSG00000152127	MGAT5	2.03516027	1.39134E-4	0.004051062
ENSG00000100139	MICALL1	2.15083647	1.53E-6	9.4E-5
ENSG00000107745	MICU1	2.29403592	1.91E-6	1.14383E-4
ENSG00000165175	MID1IP1	3.062441639	2.03E-8	2.28E-6
ENSG00000125457	MIF4GD	2.65174433	8.45E-6	3.96592E-4
ENSG00000116691	MIIP	2.61678544	2.12699E-4	0.005645861
ENSG00000173436	MINOS1	1.858005115	9.69E-6	4.42983E-4
ENSG00000172965	MIR4435-2HG	2.264585989	7.75E-5	0.002516755
ENSG00000265438	MIR4751	13.02075987	3.21E-7	2.5E-5
ENSG00000236901	MIR600HG	-3.763914049	1.24097E-4	0.00368504
ENSG00000148773	MKI67	2.937475212	2.22E-6	1.28991E-4
ENSG00000099875	MKNK2	2.120429673	4.23E-6	2.23867E-4
ENSG00000089693	MLF2	2.142674669	7.79E-6	3.70992E-4
ENSG00000076242	MLH1	1.716657002	1.98848E-4	0.005346516
ENSG00000167965	MLST8	2.266432536	3.69E-6	1.98831E-4
ENSG00000142606	MMEL1	2.850768876	4.27E-5	0.001536924
ENSG00000157227	MMP14	2.547054193	8.92E-9	1.07E-6
ENSG00000008516	MMP25	-7.518680435	1.09409E-4	0.003329586
ENSG00000100985	MMP9	5.807491831	3.37E-9	4.64E-7
ENSG00000138722	MMRN1	-4.59871555	1.74E-7	1.44E-5
ENSG00000020426	MNAT1	1.927448705	8.32E-5	0.002671865
ENSG00000075643	MOCOS	1.81468223	3.32112E-4	0.008133248
ENSG00000060762	MPC1	2.990972574	9.01E-10	1.41E-7
ENSG00000129255	MPDU1	1.837542804	1.59195E-4	0.004487415
ENSG00000197629	MPEG1	2.493946117	1.0E-7	8.97E-6
ENSG00000115204	MPV17	1.863545362	3.14E-6	1.73598E-4
ENSG00000254858	MPV17L2	4.005234933	6.06E-8	5.73E-6
ENSG00000170262	MRAP	3.420233426	6.08E-5	0.002062558
ENSG00000180992	MRPL14	2.371529665	1.52163E-4	0.004321823
ENSG00000158042	MRPL17	3.745781125	1.32E-15	5.26E-13
ENSG00000197345	MRPL21	1.857164813	2.39324E-4	0.00623143
ENSG00000143314	MRPL24	1.923600001	2.07961E-4	0.005549039
ENSG00000185414	MRPL30	2.427425386	2.14E-6	1.25654E-4
ENSG00000171421	MRPL36	2.622698309	1.90387E-4	0.005168453
ENSG00000116221	MRPL37	2.411050654	7.45E-7	5.13E-5
ENSG00000055950	MRPL43	2.00546962	1.27306E-4	0.003773299
ENSG00000136522	MRPL47	2.485904376	2.76E-5	0.001070934
ENSG00000111639	MRPL51	2.06095858	5.24E-5	0.001810098
ENSG00000172590	MRPL52	2.16066639	7.57E-6	3.6383E-4
ENSG00000183617	MRPL54	2.456337666	1.77912E-4	0.004907878
ENSG00000162910	MRPL55	2.234618507	6.82E-5	0.002275387
ENSG00000116898	MRPS15	2.32113173	2.74E-9	3.87E-7
ENSG00000182180	MRPS16	1.802451809	2.0E-5	8.1761E-4
ENSG00000122140	MRPS2	2.288275908	1.75E-6	1.06259E-4
ENSG00000112996	MRPS30	1.754845396	7.45E-5	0.002438507
ENSG00000074071	MRPS34	3.002611555	5.67E-10	9.35E-8
ENSG00000243927	MRPS6	1.918505358	1.41066E-4	0.004093376
ENSG00000125445	MRPS7	1.953470752	1.79869E-4	0.004944735
ENSG00000072952	MRVI1	-2.14363516	2.76694E-4	0.007009634
ENSG00000110079	MS4A4A	1.93500001	3.32E-5	0.00125112
ENSG00000166927	MS4A7	2.215992868	1.77E-6	1.07088E-4
ENSG00000178860	MSC	11.36701323	8.66E-46	3.45E-42
ENSG00000235531	MSC-AS1	6.216951864	6.1E-37	1.27E-33
ENSG00000052802	MSMO1	2.140984953	4.18E-5	0.001511221
ENSG00000038945	MSR1	2.850194568	8.03E-10	1.29E-7
ENSG00000198899	MT-ATP6	-2.044191501	2.97321E-4	0.007437537
ENSG00000198804	MT-CO1	-2.571412822	1.22599E-4	0.003645081
ENSG00000198727	MT-CYB	-2.398858981	1.04003E-4	0.003190856
ENSG00000198888	MT-ND1	-2.209921507	8.49E-5	0.002710032
ENSG00000198786	MT-ND5	-1.953112383	6.14E-5	0.002080595
ENSG00000211459	MT-RNR1	-4018751.18	1.82078E-4	0.004993981
ENSG00000210140	MT-TC	-2.412216353	1.07E-7	9.45E-6
ENSG00000210154	MT-TD	-2.400047249	3.70282E-4	0.008845842
ENSG00000210135	MT-TN	-2.179463829	3.01E-5	0.001148748
ENSG00000210196	MT-TP	-2.474036087	1.43495E-4	0.004137637
ENSG00000210151	MT-TS1	-3.083253921	3.73E-9	5.03E-7
ENSG00000210144	MT-TY	-2.519731905	1.01E-6	6.62E-5
ENSG00000205364	MT1M	-10.76865816	1.03585E-4	0.00318686
ENSG00000109919	MTCH2	2.177833294	3.18E-5	0.001205296
ENSG00000234179	MTCYBP1	17.46837194	1.69E-8	1.93E-6
ENSG00000232373	MTCYBP3	-5.350351207	1.32537E-4	0.00389212
ENSG00000120254	MTHFD1L	3.123704807	3.78E-8	3.82E-6
ENSG00000087053	MTMR2	2.142811473	5.37E-7	3.89E-5
ENSG00000225972	MTND1P23	-2.31059062	3.97164E-4	0.009306058
ENSG00000236254	MTND4P14	-6.687389278	2.0509E-4	0.005498883
ENSG00000105887	MTPN	1.921208412	6.25E-5	0.002110145
ENSG00000132613	MTSS1L	3.135930079	3.65E-9	4.93E-7
ENSG00000169876	MUC17	-7.843849391	9.39E-5	0.002939141
ENSG00000171195	MUC7	-9.730288599	9.59E-5	0.002991854
ENSG00000167508	MVD	2.635582123	8.92E-9	1.07E-6
ENSG00000182534	MXRA7	2.165531477	1.31E-9	1.98E-7
ENSG00000172927	MYEOV	-19.16694221	4.61E-10	7.7E-8
ENSG00000109061	MYH1	-11.21275036	4.39E-5	0.001576198
ENSG00000144821	MYH15	4.440139481	5.11E-9	6.65E-7
ENSG00000101608	MYL12A	1.734084608	2.18E-5	8.77429E-4
ENSG00000118680	MYL12B	1.786128294	1.97E-5	8.08716E-4
ENSG00000101335	MYL9	2.294419241	1.73E-7	1.44E-5
ENSG00000176658	MYO1D	1.925453322	4.21E-5	0.001520927
ENSG00000197535	MYO5A	2.615328932	2.92E-16	1.24E-13
ENSG00000128833	MYO5C	-2.844187133	3.18E-9	4.42E-7
ENSG00000034971	MYOC	-7.839362421	5.76E-9	7.4E-7
ENSG00000166268	MYRFL	4.816250212	1.09E-7	9.63E-6
ENSG00000102030	NAA10	2.412921647	1.2E-11	2.58E-9
ENSG00000183011	NAA38	2.264127684	7.13E-5	0.002358204
ENSG00000166886	NAB2	2.984577664	9.01E-5	0.002856947
ENSG00000173559	NABP1	1.809120291	1.43259E-4	0.004135802
ENSG00000121089	NACA3P	-8.90613573	5.01E-8	4.88E-6
ENSG00000160877	NACC1	2.614739031	4.52E-6	2.36919E-4
ENSG00000198951	NAGA	1.873603786	3.50118E-4	0.008465741
ENSG00000108784	NAGLU	2.530199225	5.43E-7	3.92E-5
ENSG00000188613	NANOS1	7.458260132	1.36E-58	7.21E-55
ENSG00000205531	NAP1L4	3.989077009	7.51E-23	5.79E-20
ENSG00000134440	NARS	2.114824624	1.82E-6	1.09556E-4
ENSG00000149294	NCAM1	-2.096456232	9.7E-5	0.003019657
ENSG00000020129	NCDN	2.164202749	1.29E-5	5.62382E-4
ENSG00000123338	NCKAP1L	2.904286603	2.06E-9	2.99E-7
ENSG00000125912	NCLN	3.676020397	1.04E-13	3.09E-11
ENSG00000162736	NCSTN	2.474381196	2.68E-8	2.87E-6
ENSG00000182636	NDN	1.939304232	3.29E-5	0.001245304
ENSG00000125356	NDUFA1	2.185299429	7.99E-6	3.78492E-4
ENSG00000174886	NDUFA11	2.361315056	1.67E-8	1.91E-6
ENSG00000184752	NDUFA12	2.24455403	1.14E-5	5.12199E-4
ENSG00000186010	NDUFA13	2.963380766	3.39E-7	2.61E-5
ENSG00000131495	NDUFA2	1.955327842	3.63E-6	1.96314E-4
ENSG00000189043	NDUFA4	1.977848712	7.72E-5	0.002508181
ENSG00000185633	NDUFA4L2	2.220346849	2.17E-5	8.73615E-4
ENSG00000184983	NDUFA6	1.879716148	8.87E-5	0.002818101
ENSG00000119421	NDUFA8	1.978075161	5.16E-5	0.001790285
ENSG00000178057	NDUFAF3	2.483111097	2.07E-8	2.31E-6
ENSG00000065518	NDUFB4	2.291824929	8.89E-7	5.93E-5
ENSG00000099795	NDUFB7	1.967430797	3.92513E-4	0.009233809
ENSG00000147684	NDUFB9	1.964912482	1.51793E-4	0.004314409
ENSG00000151366	NDUFC2	2.069039108	9.2E-6	4.25386E-4
ENSG00000164258	NDUFS4	2.056635222	4.42E-5	0.001585579
ENSG00000145494	NDUFS6	2.505366672	6.98E-8	6.48E-6
ENSG00000110717	NDUFS8	2.072886658	1.24E-6	7.84E-5
ENSG00000160194	NDUFV3	1.732779122	1.30221E-4	0.003843011
ENSG00000204356	NELFE	2.039370554	9.23E-7	6.12E-5
ENSG00000166881	NEMP1	2.322690833	4.48E-9	5.9E-7
ENSG00000067141	NEO1	2.202020843	4.81E-6	2.50575E-4
ENSG00000162614	NEXN	-3.30842233	2.95E-6	1.64488E-4
ENSG00000163531	NFASC	-4.286616808	9.28E-8	8.37E-6
ENSG00000082641	NFE2L1	1.695208817	3.73978E-4	0.008907426
ENSG00000116044	NFE2L2	1.798096461	1.54E-5	6.57448E-4
ENSG00000144802	NFKBIZ	-2.892874883	2.04E-5	8.33605E-4
ENSG00000182768	NGRN	2.658708736	1.21E-15	4.92E-13
ENSG00000171786	NHLH1	4.960994602	1.38E-9	2.07E-7
ENSG00000145912	NHP2	2.394287047	9.25E-8	8.35E-6
ENSG00000087303	NID2	2.057533411	2.71E-5	0.001052661
ENSG00000131669	NINJ1	3.720182671	3.14E-10	5.47E-8
ENSG00000132603	NIP7	1.974892051	3.52964E-4	0.008504417
ENSG00000136783	NIPSNAP3A	1.877183966	3.49892E-4	0.008465741
ENSG00000168256	NKIRAS2	2.162760066	4.07E-7	3.05E-5
ENSG00000165246	NLGN4Y	4.841636815	5.49E-8	5.27E-6
ENSG00000087095	NLK	1.823758754	9.38E-5	0.002939141
ENSG00000239672	NME1	2.68231733	8.75E-10	1.38E-7
ENSG00000011052	NME1-NME2	3.176923015	6.59E-11	1.3E-8
ENSG00000243678	NME2	2.572093383	3.49388E-4	0.008465206
ENSG00000166741	NNMT	-2.351948323	1.83052E-4	0.005009188
ENSG00000165271	NOL6	2.090742993	4.86E-5	0.001700405
ENSG00000182117	NOP10	2.233032507	1.4E-5	6.04597E-4
ENSG00000048162	NOP16	2.204086901	2.65E-6	1.49999E-4
ENSG00000170485	NPAS2	7.545635617	3.04E-48	1.32E-44
ENSG00000015520	NPC1L1	-4.436340736	7.51E-5	0.002455636
ENSG00000135838	NPL	2.827082692	5.99E-6	3.02342E-4
ENSG00000181163	NPM1	1.782658028	1.57214E-4	0.004442067
ENSG00000221890	NPTXR	2.426214195	4.64E-8	4.57E-6
ENSG00000164128	NPY1R	-5.47162378	7.61E-7	5.23E-5
ENSG00000164129	NPY5R	-6.416427077	1.47E-5	6.33363E-4
ENSG00000181019	NQO1	5.142409182	4.6E-33	7.08E-30
ENSG00000124588	NQO2	2.231136108	2.09648E-4	0.005587083
ENSG00000126368	NR1D1	4.924396317	3.4E-30	4.16E-27
ENSG00000025434	NR1H3	1.88598094	3.95E-5	0.001441228
ENSG00000175745	NR2F1	-4.073485776	7.8E-5	0.002530302
ENSG00000160113	NR2F6	2.167911203	1.29E-5	5.62382E-4
ENSG00000123358	NR4A1	-6.106974381	1.49505E-4	0.004269689
ENSG00000116833	NR5A2	-3.294518141	7.58E-12	1.72E-9
ENSG00000148200	NR6A1	-4.535678538	4.2E-5	0.001515377
ENSG00000148572	NRBF2	2.367869441	5.74E-7	4.11E-5
ENSG00000115216	NRBP1	1.692627987	2.14041E-4	0.005672019
ENSG00000125841	NRSN2	2.827393709	1.68E-9	2.47E-7
ENSG00000035681	NSMAF	3.471819553	3.48E-18	1.89E-15
ENSG00000165802	NSMF	2.547282358	7.76E-6	3.70522E-4
ENSG00000148335	NTMT1	3.594829904	2.82E-8	2.99E-6
ENSG00000140538	NTRK3	-6.19948148	7.89E-11	1.53E-8
ENSG00000074590	NUAK1	-2.717176467	5.0E-7	3.64E-5
ENSG00000070081	NUCB2	1.846891876	4.04E-6	2.15533E-4
ENSG00000189233	NUGGC	-3.994505096	2.20764E-4	0.005821124
ENSG00000176046	NUPR1	3.541000566	6.52E-28	6.92E-25
ENSG00000102898	NUTF2	2.765712265	1.25E-5	5.48875E-4
ENSG00000182379	NXPH4	5.398510718	2.1E-13	5.89E-11
ENSG00000184232	OAF	3.48021529	1.44E-17	7.22E-15
ENSG00000089127	OAS1	2.124491123	8.95E-5	0.002840185
ENSG00000104904	OAZ1	1.820239887	9.15E-5	0.002882447
ENSG00000115758	ODC1	3.110879757	4.77E-12	1.11E-9
ENSG00000105953	OGDH	1.88022882	1.42249E-4	0.004111626
ENSG00000087263	OGFOD1	1.852591242	2.96E-6	1.65211E-4
ENSG00000147162	OGT	1.820245102	4.66E-5	0.001655735
ENSG00000138430	OLA1	1.800584631	2.88E-5	0.001108335
ENSG00000162745	OLFML2B	3.421563539	2.3E-13	6.34E-11
ENSG00000144909	OSBPL11	4.161679515	2.18E-18	1.22E-15
ENSG00000116885	OSCP1	2.196393967	2.55E-5	9.98027E-4
ENSG00000140961	OSGIN1	7.136406366	3.16E-28	3.43E-25
ENSG00000228474	OST4	1.91683796	3.00201E-4	0.007497808
ENSG00000081087	OSTM1	2.049050208	5.42E-8	5.21E-6
ENSG00000089723	OTUB2	3.160927371	2.46E-8	2.68E-6
ENSG00000169313	P2RY12	3.992448666	1.1E-5	4.92398E-4
ENSG00000182162	P2RY8	3.330543101	7.63E-6	3.65953E-4
ENSG00000122884	P4HA1	2.208319918	9.5E-5	0.002967667
ENSG00000072682	P4HA2	1.916218333	2.25E-5	9.02051E-4
ENSG00000090621	PABPC4	1.862920438	2.26E-5	9.0614E-4
ENSG00000179364	PACS2	1.690491538	4.83E-5	0.001696312
ENSG00000168092	PAFAH1B2	1.567936708	2.69952E-4	0.006860649
ENSG00000076641	PAG1	2.897902267	1.13E-11	2.47E-9
ENSG00000128050	PAICS	2.010986791	6.99E-7	4.88E-5
ENSG00000217930	PAM16	2.536828224	1.37E-6	8.56E-5
ENSG00000120137	PANK3	2.058022784	9.12E-9	1.09E-6
ENSG00000110218	PANX1	2.298915839	1.56341E-4	0.00442264
ENSG00000116288	PARK7	1.863600569	5.55E-5	0.001901762
ENSG00000166889	PATL1	2.135464403	1.01E-7	8.97E-6
ENSG00000196092	PAX5	-36.76801707	2.65897E-4	0.006782857
ENSG00000267107	PCAT19	-2.19059396	2.12E-5	8.60892E-4
ENSG00000166228	PCBD1	1.909850892	1.50551E-4	0.004294432
ENSG00000114054	PCCB	1.885604675	1.56E-5	6.63603E-4
ENSG00000189184	PCDH18	2.119573309	1.09035E-4	0.003320314
ENSG00000165194	PCDH19	-2.193786505	2.2E-5	8.83219E-4
ENSG00000169851	PCDH7	2.185794	9.34E-7	6.16E-5
ENSG00000248383	PCDHAC1	9.533074898	2.32E-30	2.91E-27
ENSG00000243232	PCDHAC2	10.90856629	1.64E-22	1.22E-19
ENSG00000253953	PCDHGB4	2.243501149	1.23891E-4	0.003681202
ENSG00000124253	PCK1	-3.339781062	3.78617E-4	0.008973763
ENSG00000100889	PCK2	2.662717449	3.57E-7	2.73E-5
ENSG00000186472	PCLO	-5.148188266	7.57E-13	1.94E-10
ENSG00000135749	PCNXL2	-1.852566169	2.13631E-4	0.005667455
ENSG00000185813	PCYT2	2.046024339	4.21058E-4	0.009775369
ENSG00000106244	PDAP1	1.661467587	3.8221E-4	0.009035934
ENSG00000105185	PDCD5	1.775407841	3.02468E-4	0.007538654
ENSG00000197461	PDGFA	2.369172081	9.66E-7	6.35E-5
ENSG00000143870	PDIA6	1.778322968	3.43558E-4	0.008328184
ENSG00000088356	PDRG1	2.410765278	3.68653E-4	0.008820159
ENSG00000241360	PDXP	4.251669626	5.01E-6	2.59117E-4
ENSG00000120509	PDZD11	1.905503606	5.01E-5	0.001746336
ENSG00000162734	PEA15	2.923551738	3.23E-17	1.55E-14
ENSG00000089220	PEBP1	1.884858732	1.98E-5	8.08946E-4
ENSG00000242265	PEG10	4.523944214	6.43E-37	1.28E-33
ENSG00000157911	PEX10	2.39916511	1.64003E-4	0.004601239
ENSG00000112357	PEX7	2.250281973	2.08E-5	8.48249E-4
ENSG00000123349	PFDN5	1.661648443	9.18E-5	0.002886792
ENSG00000158571	PFKFB1	-4.188182956	3.47E-7	2.67E-5
ENSG00000170525	PFKFB3	-4.430418734	2.78E-8	2.96E-6
ENSG00000141959	PFKL	1.802500047	1.45819E-4	0.00419452
ENSG00000108518	PFN1	2.274171561	2.38E-7	1.9E-5
ENSG00000171314	PGAM1	2.08573056	1.27737E-4	0.003783738
ENSG00000161395	PGAP3	2.266697232	3.59198E-4	0.00861552
ENSG00000142657	PGD	3.031060182	9.56E-12	2.11E-9
ENSG00000184207	PGP	3.02629669	1.17E-5	5.22164E-4
ENSG00000167085	PHB	1.839980003	1.75804E-4	0.00485534
ENSG00000215021	PHB2	2.259503622	7.12E-7	4.94E-5
ENSG00000112511	PHF1	1.680593823	2.85412E-4	0.007188558
ENSG00000181649	PHLDA2	4.280212018	3.03486E-4	0.007556162
ENSG00000174307	PHLDA3	2.145900162	3.43E-6	1.87834E-4
ENSG00000144824	PHLDB2	-1.837401921	1.72256E-4	0.004771146
ENSG00000081913	PHLPP1	-2.071252622	1.7146E-4	0.004753283
ENSG00000054148	PHPT1	2.81404702	3.82E-11	7.67E-9
ENSG00000107537	PHYH	1.799838003	3.2656E-4	0.008046788
ENSG00000143393	PI4KB	1.657258738	3.24354E-4	0.007996544
ENSG00000101464	PIGU	2.281141809	2.21E-6	1.28394E-4
ENSG00000155629	PIK3AP1	2.380505446	1.4489E-4	0.00417496
ENSG00000087842	PIR	2.593589799	1.32E-8	1.55E-6
ENSG00000205038	PKHD1L1	-7.282603745	2.15667E-4	0.005711952
ENSG00000067225	PKM	3.165747013	3.52E-14	1.14E-11
ENSG00000123143	PKN1	2.879960096	2.55E-11	5.21E-9
ENSG00000137055	PLAA	2.225391427	1.0E-6	6.55E-5
ENSG00000181690	PLAG1	4.300488102	1.68E-15	6.41E-13
ENSG00000104368	PLAT	-2.85265469	1.76E-6	1.06725E-4
ENSG00000122861	PLAU	2.085813859	3.37459E-4	0.008222048
ENSG00000151176	PLBD2	2.361186437	1.09E-6	7.03E-5
ENSG00000137841	PLCB2	2.432539049	5.27E-5	0.001818783
ENSG00000101333	PLCB4	-2.973747721	2.22E-6	1.28991E-4
ENSG00000138193	PLCE1	-3.255689835	3.2E-8	3.3E-6
ENSG00000182378	PLCXD1	1.76989464	1.49328E-4	0.004269533
ENSG00000182836	PLCXD3	-2.412908643	1.63442E-4	0.004590897
ENSG00000105223	PLD3	2.015718615	6.87E-5	0.002286753
ENSG00000115956	PLEK	2.525256639	8.7E-6	4.06421E-4
ENSG00000152527	PLEKHH2	-2.615284123	3.8E-7	2.88E-5
ENSG00000116786	PLEKHM2	2.517433522	1.25E-7	1.08E-5
ENSG00000241839	PLEKHO2	4.795081314	1.41E-29	1.68E-26
ENSG00000107020	PLGRKT	2.618483913	8.55E-6	4.00924E-4
ENSG00000166819	PLIN1	-1.956587512	4.30288E-4	0.009926967
ENSG00000147872	PLIN2	4.937909695	1.15E-43	3.67E-40
ENSG00000214456	PLIN5	-2.665548309	1.07E-6	6.93E-5
ENSG00000152952	PLOD2	2.07426545	7.04E-5	0.002335914
ENSG00000106397	PLOD3	2.027944488	3.04E-6	1.69311E-4
ENSG00000123560	PLP1	-3.751424695	3.11662E-4	0.007735533
ENSG00000100979	PLTP	2.714554395	7.24E-8	6.67E-6
ENSG00000114554	PLXNA1	2.511872909	4.14E-9	5.49E-7
ENSG00000130827	PLXNA3	1.700073152	2.16473E-4	0.005730116
ENSG00000004399	PLXND1	1.875242995	6.01E-6	3.03003E-4
ENSG00000163344	PMVK	2.0978087	1.97E-5	8.07237E-4
ENSG00000127838	PNKD	2.079925093	6.63E-6	3.27644E-4
ENSG00000176903	PNMA1	2.408868843	2.35E-8	2.57E-6
ENSG00000115946	PNO1	2.194431489	1.51E-6	9.33E-5
ENSG00000189266	PNRC2	1.950759635	1.59E-6	9.74E-5
ENSG00000106628	POLD2	2.915983774	3.53E-7	2.71E-5
ENSG00000004142	POLDIP2	2.371116128	4.8E-7	3.53E-5
ENSG00000148229	POLE3	1.870192239	2.58603E-4	0.006635775
ENSG00000068654	POLR1A	1.694712374	8.4E-5	0.002688498
ENSG00000147669	POLR2K	2.732336627	1.95E-8	2.2E-6
ENSG00000013503	POLR3B	1.900371057	2.01065E-4	0.00539701
ENSG00000085998	POMGNT1	2.02894596	3.93E-6	2.10467E-4
ENSG00000132963	POMP	1.976056774	1.04E-5	4.71039E-4
ENSG00000172336	POP7	3.375900161	1.22E-5	5.37818E-4
ENSG00000127948	POR	2.203711096	2.18E-7	1.75E-5
ENSG00000106536	POU6F2	-3.517628569	1.01516E-4	0.003135318
ENSG00000128059	PPAT	2.585558629	1.27E-5	5.57335E-4
ENSG00000125534	PPDPF	3.594170955	2.34E-16	1.01E-13
ENSG00000166387	PPFIBP2	1.714984216	5.51E-5	0.001886973
ENSG00000196262	PPIA	2.012755844	1.92E-6	1.15213E-4
ENSG00000166794	PPIB	2.025601575	1.03103E-4	0.003176114
ENSG00000108179	PPIF	2.459708013	3.87E-7	2.92E-5
ENSG00000137168	PPIL1	4.5503142	3.1E-8	3.24E-6
ENSG00000145725	PPIP5K2	1.815233391	4.13574E-4	0.009625002
ENSG00000204619	PPP1R11	2.157982598	8.85E-9	1.07E-6
ENSG00000173457	PPP1R14B	2.786529795	3.08E-8	3.23E-6
ENSG00000101445	PPP1R16B	-2.061882351	2.35853E-4	0.006157832
ENSG00000131771	PPP1R1B	-6.570960479	1.97E-10	3.54E-8
ENSG00000184203	PPP1R2	1.608679382	1.94994E-4	0.005266598
ENSG00000119938	PPP1R3C	2.275443132	3.19E-5	0.001209243
ENSG00000105568	PPP2R1A	2.08710012	1.92E-5	7.95836E-4
ENSG00000137713	PPP2R1B	2.343121572	1.18E-10	2.22E-8
ENSG00000131238	PPT1	2.28663659	2.47E-5	9.70507E-4
ENSG00000196850	PPTC7	1.941498036	6.62E-6	3.27644E-4
ENSG00000174899	PQLC2L	2.274595039	1.24E-6	7.84E-5
ENSG00000243279	PRAF2	2.268668292	9.2E-5	0.002891345
ENSG00000214140	PRCD	2.814171945	2.13E-8	2.38E-6
ENSG00000117450	PRDX1	1.70915317	2.64761E-4	0.006757496
ENSG00000126432	PRDX5	1.968005407	1.16824E-4	0.003510516
ENSG00000138073	PREB	2.824773398	1.66E-7	1.38E-5
ENSG00000101166	PRELID3B	2.222328697	6.89E-6	3.37738E-4
ENSG00000188783	PRELP	-3.623457147	5.3E-11	1.05E-8
ENSG00000138078	PREPL	1.762231439	2.54593E-4	0.006564596
ENSG00000116690	PRG4	-5.925929049	1.7574E-4	0.00485534
ENSG00000072062	PRKACA	2.127371503	1.51E-6	9.33E-5
ENSG00000171132	PRKCE	2.41761546	1.45E-10	2.66E-8
ENSG00000099725	PRKY	3.653242776	1.62E-8	1.88E-6
ENSG00000185238	PRMT3	2.862455494	1.46E-6	9.05E-5
ENSG00000100462	PRMT5	2.267423349	2.13E-7	1.72E-5
ENSG00000171867	PRNP	3.038668091	1.76E-10	3.19E-8
ENSG00000117707	PROX1	-7.359858777	1.25E-5	5.49903E-4
ENSG00000110107	PRPF19	2.399921016	1.14E-7	9.97E-6
ENSG00000241990	PRR34-AS1	3.425068455	1.82444E-4	0.005001138
ENSG00000230082	PRRT3-AS1	2.561670375	2.78E-5	0.001078975
ENSG00000197746	PSAP	2.66329565	3.71E-15	1.35E-12
ENSG00000135069	PSAT1	9.85847148	3.41E-43	1.02E-39
ENSG00000242221	PSG2	-10.53679348	1.47E-5	6.31223E-4
ENSG00000100567	PSMA3	2.095814254	4.48E-6	2.34895E-4
ENSG00000041357	PSMA4	2.708898519	1.77E-10	3.19E-8
ENSG00000143106	PSMA5	1.911597672	1.0E-5	4.54276E-4
ENSG00000205220	PSMB10	3.128180382	1.3E-8	1.53E-6
ENSG00000100804	PSMB5	2.0950978	9.19E-6	4.25386E-4
ENSG00000142507	PSMB6	2.379238204	1.37E-9	2.05E-7
ENSG00000136930	PSMB7	2.195402564	3.48E-6	1.89863E-4
ENSG00000013275	PSMC4	2.185460162	5.74E-8	5.48E-6
ENSG00000101843	PSMD10	2.174538022	1.47241E-4	0.004231198
ENSG00000115233	PSMD14	2.838889126	3.63E-10	6.21E-8
ENSG00000175166	PSMD2	1.733702643	1.96298E-4	0.005292834
ENSG00000108344	PSMD3	1.900103229	5.28E-6	2.71707E-4
ENSG00000103035	PSMD7	2.065048602	1.17E-5	5.2184E-4
ENSG00000099341	PSMD8	2.520177155	6.22E-9	7.91E-7
ENSG00000092010	PSME1	1.942126797	5.22E-5	0.001807365
ENSG00000131467	PSME3	2.062316591	2.55E-6	1.45399E-4
ENSG00000125818	PSMF1	2.221756161	2.65E-6	1.49999E-4
ENSG00000183527	PSMG1	2.267837593	2.69E-7	2.13E-5
ENSG00000165983	PTER	3.025093659	1.12E-9	1.71E-7
ENSG00000148334	PTGES2	1.98166711	3.58722E-4	0.00861276
ENSG00000122420	PTGFR	3.290040125	1.66E-7	1.38E-5
ENSG00000184007	PTP4A2	1.836267642	3.18E-5	0.001205296
ENSG00000184489	PTP4A3	2.755424876	5.67E-6	2.88336E-4
ENSG00000076201	PTPN23	1.852112874	1.17143E-4	0.003515678
ENSG00000081237	PTPRC	1.907353736	1.90996E-4	0.005182056
ENSG00000152894	PTPRK	1.75625642	1.60758E-4	0.004526139
ENSG00000139304	PTPRQ	-3.286177709	8.29E-5	0.002664582
ENSG00000187024	PTRH1	2.289116361	4.46E-5	0.001598769
ENSG00000163661	PTX3	3.78620071	6.65E-6	3.28053E-4
ENSG00000169972	PUSL1	3.370556751	4.75E-5	0.001676184
ENSG00000073008	PVR	1.85529039	4.35213E-4	0.009997141
ENSG00000171813	PWWP2B	3.975941898	1.66E-8	1.91E-6
ENSG00000168994	PXDC1	2.235384303	6.54E-7	4.61E-5
ENSG00000168297	PXK	2.389236357	3.52E-6	1.91646E-4
ENSG00000103490	PYCARD	2.852713492	2.48445E-4	0.006431153
ENSG00000100994	PYGB	1.894686388	9.87E-5	0.003061507
ENSG00000163348	PYGO2	1.984320294	1.56E-5	6.64476E-4
ENSG00000116260	QSOX1	1.985212779	4.29E-6	2.26559E-4
ENSG00000048991	R3HDM1	1.6767794	3.51983E-4	0.00849235
ENSG00000084733	RAB10	1.898270538	2.58E-6	1.46989E-4
ENSG00000107560	RAB11FIP2	2.125926006	6.87E-7	4.81E-5
ENSG00000138069	RAB1A	2.00536838	4.87E-6	2.52892E-4
ENSG00000139832	RAB20	3.023139447	3.73E-5	0.001374113
ENSG00000118508	RAB32	4.355801111	2.67E-15	9.88E-13
ENSG00000123892	RAB38	4.66649733	4.31E-5	0.001549314
ENSG00000168118	RAB4A	2.159182065	6.63E-5	0.002223983
ENSG00000108774	RAB5C	1.706888493	1.28076E-4	0.00378908
ENSG00000075785	RAB7A	2.033736239	4.51E-7	3.32E-5
ENSG00000029725	RABEP1	1.811554018	1.4123E-4	0.004093376
ENSG00000183155	RABIF	2.517778463	3.13E-5	0.001192373
ENSG00000196642	RABL6	2.027369414	3.51E-8	3.58E-6
ENSG00000179262	RAD23A	1.798604603	1.39458E-4	0.00405796
ENSG00000119318	RAD23B	1.859332515	3.73E-5	0.001374113
ENSG00000108384	RAD51C	2.361644404	7.69E-7	5.26E-5
ENSG00000006451	RALA	2.283839776	7.92E-7	5.39E-5
ENSG00000132341	RAN	2.167722625	2.31E-8	2.54E-6
ENSG00000138698	RAP1GDS1	2.814914949	1.04E-16	4.67E-14
ENSG00000181467	RAP2B	2.29986287	2.17E-7	1.75E-5
ENSG00000079337	RAPGEF3	-1.979866963	5.72E-6	2.90029E-4
ENSG00000133321	RARRES3	3.215409405	1.5E-5	6.4379E-4
ENSG00000146282	RARS2	1.665843405	3.76971E-4	0.008956388
ENSG00000103710	RASL12	2.984968561	2.11E-6	1.24627E-4
ENSG00000101773	RBBP8	2.214910597	8.39E-6	3.9405E-4
ENSG00000125826	RBCK1	2.966389443	1.53E-15	5.91E-13
ENSG00000119446	RBM18	2.276379071	2.2E-6	1.28291E-4
ENSG00000100387	RBX1	2.074062767	2.46E-6	1.41138E-4
ENSG00000179051	RCC2	1.860241488	9.16E-5	0.002883959
ENSG00000142552	RCN3	2.475832445	3.79E-9	5.08E-7
ENSG00000088320	REM1	-3.685301804	1.14551E-4	0.003455257
ENSG00000134533	RERG	-2.532035629	3.30776E-4	0.008113001
ENSG00000165731	RET	5.543197529	5.06E-26	4.93E-23
ENSG00000076043	REXO2	1.888317082	1.79E-5	7.47301E-4
ENSG00000148300	REXO4	2.37045597	4.2E-7	3.14E-5
ENSG00000169733	RFNG	2.480379325	1.09E-5	4.91314E-4
ENSG00000143344	RGL1	1.83126041	2.22718E-4	0.005866174
ENSG00000182175	RGMA	-3.83733095	8.05E-5	0.002603709
ENSG00000005486	RHBDD2	3.707329975	4.59E-18	2.47E-15
ENSG00000008853	RHOBTB2	2.463929754	3.42E-6	1.87554E-4
ENSG00000173156	RHOD	3.1281968	7.78E-6	3.70992E-4
ENSG00000177105	RHOG	2.170396028	2.87E-6	1.60485E-4
ENSG00000188026	RILPL1	2.336514078	5.48E-6	2.80549E-4
ENSG00000117016	RIMS3	4.369592322	1.99E-7	1.62E-5
ENSG00000137824	RMDN3	2.10701463	2.74E-6	1.54283E-4
ENSG00000155906	RMND1	2.071813832	2.35E-5	9.32753E-4
ENSG00000129538	RNASE1	2.563828281	1.5E-7	1.26E-5
ENSG00000219200	RNASEK	2.177363705	2.79E-5	0.001080001
ENSG00000141576	RNF157	1.917945833	5.46E-7	3.93E-5
ENSG00000141622	RNF165	1.968170782	2.83347E-4	0.007151622
ENSG00000138942	RNF185	2.366079683	3.62E-9	4.91E-7
ENSG00000168159	RNF187	3.443753585	2.09E-17	1.03E-14
ENSG00000101236	RNF24	3.350176498	7.31E-15	2.59E-12
ENSG00000108375	RNF43	-8.989805305	4.16E-6	2.20949E-4
ENSG00000127870	RNF6	1.842855931	1.01706E-4	0.003139156
ENSG00000023191	RNH1	2.266628244	6.44E-9	8.12E-7
ENSG00000176393	RNPEP	2.091196621	6.8E-5	0.002270845
ENSG00000142327	RNPEPL1	2.282461361	1.3E-5	5.66201E-4
ENSG00000185483	ROR1	2.309329045	3.59E-6	1.94796E-4
ENSG00000005175	RPAP3	1.959878269	2.02532E-4	0.005433329
ENSG00000197713	RPE	1.944443483	3.79345E-4	0.008985987
ENSG00000089169	RPH3A	-7.805724278	2.90353E-4	0.00729763
ENSG00000230734	RPL10P3	2.124987457	4.84E-7	3.55E-5
ENSG00000197958	RPL12	2.232642746	2.48E-6	1.41733E-4
ENSG00000167526	RPL13	1.929177819	1.48894E-4	0.004262429
ENSG00000142541	RPL13A	1.90743169	1.04615E-4	0.003206153
ENSG00000188846	RPL14	1.749410281	4.19158E-4	0.009745466
ENSG00000265681	RPL17	2.164597412	3.34E-6	1.83643E-4
ENSG00000063177	RPL18	2.115271109	4.62E-5	0.001643156
ENSG00000105640	RPL18A	2.09656231	3.95E-5	0.001441228
ENSG00000108298	RPL19	2.070039491	1.23E-6	7.82E-5
ENSG00000122026	RPL21	1.734283361	4.26864E-4	0.009862251
ENSG00000114391	RPL24	1.837708918	2.28E-5	9.09858E-4
ENSG00000161970	RPL26	1.940200509	1.94E-5	8.0075E-4
ENSG00000108107	RPL28	2.356707405	1.03E-7	9.13E-6
ENSG00000162244	RPL29	1.899805703	5.38E-5	0.001854534
ENSG00000156482	RPL30	1.723141486	2.14E-5	8.6553E-4
ENSG00000071082	RPL31	2.007015567	4.92E-6	2.55165E-4
ENSG00000144713	RPL32	1.939884671	1.67338E-4	0.004675587
ENSG00000136942	RPL35	2.249733527	3.02E-6	1.68272E-4
ENSG00000130255	RPL36	2.708082525	7.69E-9	9.62E-7
ENSG00000241343	RPL36A	1.716344562	1.50509E-4	0.004294432
ENSG00000145592	RPL37	1.884564363	5.56E-6	2.83793E-4
ENSG00000197756	RPL37A	2.271121684	3.55E-6	1.92995E-4
ENSG00000172809	RPL38	2.078744753	6.92E-6	3.38669E-4
ENSG00000174444	RPL4	1.988948838	3.9E-6	2.09122E-4
ENSG00000229117	RPL41	2.169175605	6.82E-7	4.79E-5
ENSG00000148303	RPL7A	1.931946836	8.79E-5	0.002798397
ENSG00000161016	RPL8	2.095188027	1.96E-5	8.06386E-4
ENSG00000163682	RPL9	1.882779783	1.35095E-4	0.003955082
ENSG00000089157	RPLP0	1.928905507	5.4E-5	0.001857259
ENSG00000137818	RPLP1	2.374157316	3.91E-7	2.94E-5
ENSG00000163902	RPN1	1.968633933	4.0E-5	0.001454933
ENSG00000118705	RPN2	2.21547541	8.87E-8	8.06E-6
ENSG00000164967	RPP25L	2.871776929	1.72589E-4	0.004777588
ENSG00000124614	RPS10	2.368980229	9.27E-7	6.13E-5
ENSG00000142534	RPS11	1.856324334	3.15766E-4	0.007821143
ENSG00000112306	RPS12	2.674636506	2.17E-10	3.89E-8
ENSG00000110700	RPS13	1.908965105	4.87E-5	0.001700894
ENSG00000115268	RPS15	2.040089255	7.21E-5	0.002371991
ENSG00000105193	RPS16	2.055237496	5.44E-5	0.001865591
ENSG00000105372	RPS19	2.17911484	3.18E-5	0.001205296
ENSG00000140988	RPS2	2.339486317	8.53E-7	5.73E-5
ENSG00000171858	RPS21	2.209900154	1.09865E-4	0.003341344
ENSG00000138326	RPS24	1.908059885	2.44E-5	9.61027E-4
ENSG00000185088	RPS27L	2.107042821	1.27E-7	1.1E-5
ENSG00000213741	RPS29	2.21649541	8.89E-5	0.002822586
ENSG00000149273	RPS3	1.842226881	9.25E-5	0.002903357
ENSG00000145425	RPS3A	1.668066396	2.55144E-4	0.006566146
ENSG00000239830	RPS4XP22	-9.634101101	1.24E-6	7.84E-5
ENSG00000129824	RPS4Y1	36.00738355	3.88E-92	4.64E-88
ENSG00000083845	RPS5	2.348003402	8.53E-7	5.73E-5
ENSG00000142937	RPS8	2.052939661	8.98E-7	5.99E-5
ENSG00000168028	RPSA	2.747873617	1.15E-10	2.17E-8
ENSG00000116954	RRAGC	2.623316727	4.3E-12	1.01E-9
ENSG00000025039	RRAGD	2.453950191	9.68E-6	4.42983E-4
ENSG00000048392	RRM2B	2.52195332	1.12E-6	7.2E-5
ENSG00000160208	RRP1B	1.888577392	2.46726E-4	0.006396259
ENSG00000137876	RSL24D1	1.823126719	9.18E-5	0.002886792
ENSG00000133318	RTN3	1.97416105	7.39E-6	3.57503E-4
ENSG00000115310	RTN4	2.250430102	1.05E-5	4.74306E-4
ENSG00000018189	RUFY3	2.116218098	7.42E-6	3.5855E-4
ENSG00000175792	RUVBL1	2.033227681	1.01E-6	6.59E-5
ENSG00000160678	S100A1	-3.524237961	1.96474E-4	0.005294607
ENSG00000163191	S100A11	2.28819704	5.82E-8	5.52E-6
ENSG00000188643	S100A16	2.409669886	1.27E-5	5.57335E-4
ENSG00000173432	SAA1	-9.778970685	1.32E-7	1.13E-5
ENSG00000134339	SAA2	-5.826864955	9.72E-6	4.4411E-4
ENSG00000142230	SAE1	1.908642304	6.59E-7	4.64E-5
ENSG00000141858	SAMD1	2.750542077	1.15E-6	7.37E-5
ENSG00000031698	SARS	3.14510451	1.63E-13	4.66E-11
ENSG00000140497	SCAMP2	2.02098149	6.89E-6	3.37738E-4
ENSG00000171222	SCAND1	2.593157087	2.07845E-4	0.005549039
ENSG00000168077	SCARA3	3.542230859	4.05E-8	4.05E-6
ENSG00000168079	SCARA5	-4.360009331	3.97E-8	3.98E-6
ENSG00000254911	SCARNA9	2.173867125	3.4E-5	0.00127348
ENSG00000099194	SCD	2.494526457	5.94E-5	0.002024286
ENSG00000184178	SCFD2	2.196332861	3.87277E-4	0.009124125
ENSG00000168356	SCN11A	-2.953126514	3.81E-5	0.001399072
ENSG00000153253	SCN3A	-4.547885422	9.03E-5	0.002857665
ENSG00000136546	SCN7A	-3.112432091	1.86E-6	1.11502E-4
ENSG00000130489	SCO2	2.347889998	2.43E-5	9.56546E-4
ENSG00000136193	SCRN1	2.98297915	1.3E-13	3.77E-11
ENSG00000159307	SCUBE1	3.151903782	1.48819E-4	0.004262429
ENSG00000198301	SDAD1	2.096683899	2.30953E-4	0.006048667
ENSG00000162512	SDC3	3.137164417	1.66E-16	7.21E-14
ENSG00000124145	SDC4	3.011481241	3.25E-10	5.61E-8
ENSG00000137575	SDCBP	2.07076904	2.9E-6	1.62249E-4
ENSG00000165689	SDCCAG3	2.570548011	8.17E-6	3.8591E-4
ENSG00000078808	SDF4	2.204350343	8.27E-5	0.00266102
ENSG00000143252	SDHC	1.994732036	2.49598E-4	0.006453218
ENSG00000146555	SDK1	-2.235724059	2.86731E-4	0.007217982
ENSG00000101310	SEC23B	1.938117064	7.21E-5	0.002371991
ENSG00000058262	SEC61A1	2.91602604	2.22E-13	6.17E-11
ENSG00000132432	SEC61G	2.002118038	3.1E-5	0.001183899
ENSG00000071537	SEL1L	2.395105076	2.77E-9	3.9E-7
ENSG00000198843	SELT	2.13212204	1.87116E-4	0.005094127
ENSG00000012171	SEMA3B	-2.434828139	1.44964E-4	0.00417496
ENSG00000170381	SEMA3E	-3.549030816	4.05E-5	0.001468183
ENSG00000185033	SEMA4B	-2.846258631	6.6E-6	3.26964E-4
ENSG00000161956	SENP3	2.13666713	7.2E-5	0.002371991
ENSG00000086475	SEPHS1	1.766204813	1.71262E-4	0.004753283
ENSG00000179918	SEPHS2	2.449948837	1.92E-11	4.0E-9
ENSG00000100167	SEPT3	3.516192892	3.49E-5	0.001301815
ENSG00000184640	SEPT9	2.144489066	2.29E-6	1.32383E-4
ENSG00000168528	SERINC2	5.179982515	1.41E-14	4.79E-12
ENSG00000197249	SERPINA1	-5.625668349	2.13796E-4	0.005668666
ENSG00000135919	SERPINE2	2.014091548	1.16E-5	5.16918E-4
ENSG00000149257	SERPINH1	2.295613016	3.35161E-4	0.008178587
ENSG00000130766	SESN2	3.88973126	1.23E-16	5.48E-14
ENSG00000149212	SESN3	2.033770684	1.82E-6	1.09944E-4
ENSG00000152217	SETBP1	1.764550879	1.43359E-4	0.004136197
ENSG00000169976	SF3B5	2.52133516	3.73E-6	2.00201E-4
ENSG00000104332	SFRP1	-2.483583064	2.67E-6	1.50732E-4
ENSG00000145423	SFRP2	-10.70389514	3.41E-6	1.87526E-4
ENSG00000183605	SFXN4	2.733729398	7.99E-6	3.78492E-4
ENSG00000170624	SGCD	2.454405241	3.05E-7	2.38E-5
ENSG00000102683	SGCG	2.288022716	1.82E-5	7.57053E-4
ENSG00000176476	SGF29	1.959085274	1.00464E-4	0.003108861
ENSG00000166224	SGPL1	2.050783103	1.47E-7	1.24E-5
ENSG00000181523	SGSH	1.643790377	3.81804E-4	0.009032381
ENSG00000111252	SH2B3	2.671160242	3.61E-13	9.7E-11
ENSG00000142669	SH3BGRL3	2.311460809	7.45E-6	3.59422E-4
ENSG00000141985	SH3GL1	2.033924579	3.65E-5	0.001349884
ENSG00000097033	SH3GLB1	2.441799558	2.29E-8	2.52E-6
ENSG00000172985	SH3RF3	2.929515323	1.19E-11	2.57E-9
ENSG00000162105	SHANK2	-4.869921793	9.09E-5	0.002874417
ENSG00000107338	SHB	2.918258331	2.87E-5	0.00110689
ENSG00000160691	SHC1	1.927782569	5.64E-6	2.86899E-4
ENSG00000198892	SHISA4	2.898506221	2.29026E-4	0.006005847
ENSG00000182199	SHMT2	4.797852815	6.14E-23	4.81E-20
ENSG00000185960	SHOX	-2.967310705	4.29007E-4	0.009902193
ENSG00000181788	SIAH2	2.548578127	2.61E-8	2.81E-6
ENSG00000105492	SIGLEC6	3.688605406	1.00619E-4	0.003109625
ENSG00000147955	SIGMAR1	2.46583857	1.52E-6	9.39E-5
ENSG00000112246	SIM1	2.701176659	5.15E-8	4.98E-6
ENSG00000198053	SIRPA	1.690049695	1.21209E-4	0.003612743
ENSG00000113504	SLC12A7	2.151979541	9.84E-5	0.003055671
ENSG00000155380	SLC16A1	2.052706382	2.64E-6	1.49915E-4
ENSG00000135917	SLC19A3	-2.513380629	2.06E-6	1.21694E-4
ENSG00000115902	SLC1A4	3.229799816	1.96E-12	4.78E-10
ENSG00000105281	SLC1A5	2.159928503	3.62E-6	1.96125E-4
ENSG00000144136	SLC20A1	2.199368135	1.49E-5	6.39167E-4
ENSG00000163393	SLC22A15	3.167681065	3.65E-5	0.001349884
ENSG00000155886	SLC24A2	8.529551974	3.84E-9	5.13E-7
ENSG00000185052	SLC24A3	2.831058384	8.86E-9	1.07E-6
ENSG00000100075	SLC25A1	2.596159544	8.19E-7	5.54E-5
ENSG00000108528	SLC25A11	2.98369638	1.43E-6	8.91E-5
ENSG00000004864	SLC25A13	2.29875596	3.96E-6	2.1181E-4
ENSG00000177542	SLC25A22	3.28817735	4.21E-7	3.14E-5
ENSG00000013306	SLC25A39	2.469662972	3.75E-12	8.83E-10
ENSG00000077713	SLC25A43	1.991765415	2.53011E-4	0.006534394
ENSG00000160785	SLC25A44	2.115301865	3.16E-10	5.48E-8
ENSG00000005022	SLC25A5	2.211326196	5.53E-6	2.82545E-4
ENSG00000122696	SLC25A51	1.802340794	3.28643E-4	0.008077271
ENSG00000169100	SLC25A6	2.252395289	1.25E-5	5.50554E-4
ENSG00000143554	SLC27A3	2.028276498	7.31E-6	3.55107E-4
ENSG00000167114	SLC27A4	2.370547313	8.13E-5	0.002620878
ENSG00000198246	SLC29A3	2.622736091	2.20158E-4	0.005808351
ENSG00000164638	SLC29A4	3.10814275	8.66E-10	1.37E-7
ENSG00000142583	SLC2A5	6.853926807	1.93E-38	4.62E-35
ENSG00000160326	SLC2A6	2.7455867	4.85E-5	0.001698821
ENSG00000170385	SLC30A1	2.390740549	2.55064E-4	0.006566146
ENSG00000136868	SLC31A1	1.939612856	7.36E-7	5.09E-5
ENSG00000169359	SLC33A1	2.3346449	8.54E-5	0.002723246
ENSG00000176087	SLC35A4	1.931888205	2.17E-5	8.7383E-4
ENSG00000205060	SLC35B4	1.829588061	3.78E-5	0.001389583
ENSG00000181830	SLC35C1	2.64877462	1.43E-8	1.67E-6
ENSG00000213699	SLC35F6	3.03722825	3.98E-17	1.87E-14
ENSG00000123643	SLC36A1	2.009896737	1.46E-6	9.05E-5
ENSG00000111371	SLC38A1	4.187387126	1.75E-23	1.49E-20
ENSG00000169507	SLC38A11	-3.283199057	1.41284E-4	0.004093376
ENSG00000188338	SLC38A3	-7.406985857	4.00737E-4	0.009367323
ENSG00000143570	SLC39A1	1.89882698	3.52057E-4	0.00849235
ENSG00000141873	SLC39A3	2.675017109	2.65E-5	0.001034568
ENSG00000141424	SLC39A6	2.061774418	3.46E-5	0.001290638
ENSG00000168003	SLC3A2	2.447794496	1.44E-7	1.22E-5
ENSG00000114544	SLC41A3	1.847859235	2.45489E-4	0.006371106
ENSG00000142494	SLC47A1	2.454636414	4.05E-7	3.04E-5
ENSG00000211584	SLC48A1	2.558336707	3.24E-10	5.61E-8
ENSG00000164889	SLC4A2	1.951989289	1.84E-5	7.63931E-4
ENSG00000080493	SLC4A4	2.358998414	6.82E-7	4.79E-5
ENSG00000188687	SLC4A5	-2.181998293	1.02029E-4	0.003147085
ENSG00000033867	SLC4A7	1.927511582	2.36151E-4	0.006162229
ENSG00000185803	SLC52A2	3.330802122	9.02E-6	4.18785E-4
ENSG00000198743	SLC5A3	2.850936582	3.27E-8	3.35E-6
ENSG00000131389	SLC6A6	1.990355831	2.61E-5	0.001019298
ENSG00000130821	SLC6A8	1.895336436	2.60131E-4	0.006660659
ENSG00000139514	SLC7A1	5.862275089	2.11E-23	1.74E-20
ENSG00000151012	SLC7A11	3.989428724	2.62E-9	3.74E-7
ENSG00000003989	SLC7A2	2.298938168	9.16E-7	6.08E-5
ENSG00000103257	SLC7A5	5.342594065	4.81E-8	4.72E-6
ENSG00000090020	SLC9A1	2.877358807	1.71E-15	6.47E-13
ENSG00000181804	SLC9A9	1.903720956	3.71104E-4	0.008861062
ENSG00000249138	SLED1	-4.589676356	2.41661E-4	0.006285415
ENSG00000166750	SLFN5	2.596670454	1.37E-12	3.42E-10
ENSG00000127616	SMARCA4	1.792522395	1.9E-5	7.87013E-4
ENSG00000112562	SMOC2	-3.918410291	1.65E-5	6.9696E-4
ENSG00000135587	SMPD2	2.797569459	2.34052E-4	0.00611748
ENSG00000103056	SMPD3	-3.069145326	1.11497E-4	0.0033838
ENSG00000173267	SNCG	2.839463835	2.72E-7	2.15E-5
ENSG00000163597	SNHG16	2.073293222	1.42E-6	8.82E-5
ENSG00000260260	SNHG19	2.29842822	6.05E-5	0.0020523
ENSG00000242125	SNHG3	2.188470609	1.14E-6	7.31E-5
ENSG00000203875	SNHG5	2.309244606	1.86E-6	1.11502E-4
ENSG00000245910	SNHG6	1.705112194	2.26004E-4	0.005936361
ENSG00000161981	SNRNP25	2.156685829	8.0E-6	3.78492E-4
ENSG00000167088	SNRPD1	2.299301147	9.7E-5	0.003019657
ENSG00000125743	SNRPD2	1.93313092	1.4E-6	8.76E-5
ENSG00000100028	SNRPD3	1.85789394	1.20625E-4	0.00360435
ENSG00000139343	SNRPF	2.84509113	1.61E-5	6.83636E-4
ENSG00000172164	SNTB1	2.003321445	4.73E-5	0.001672958
ENSG00000172554	SNTG2	-8.227491482	9.4E-8	8.46E-6
ENSG00000100138	SNU13	1.971850019	8.82E-7	5.9E-5
ENSG00000086300	SNX10	2.970443746	6.68E-8	6.24E-6
ENSG00000147164	SNX12	2.248468857	1.29E-7	1.11E-5
ENSG00000246985	SOCS2-AS1	-2.493079471	6.02E-6	3.03171E-4
ENSG00000184557	SOCS3	-5.231263062	6.73E-6	3.31098E-4
ENSG00000142168	SOD1	1.861062783	7.16E-5	0.002363144
ENSG00000095637	SORBS1	-2.426220331	2.72E-5	0.001055588
ENSG00000137642	SORL1	-3.221867051	5.07E-8	4.91E-6
ENSG00000164736	SOX17	-3.264887503	3.14E-5	0.001192881
ENSG00000125398	SOX9	5.637826139	1.51E-13	4.34E-11
ENSG00000167182	SP2	1.75331204	2.05324E-4	0.005502053
ENSG00000006282	SPATA20	1.925699939	3.44E-5	0.001284136
ENSG00000196141	SPATS2L	1.70539406	2.11226E-4	0.005619249
ENSG00000114902	SPCS1	2.408260169	3.17E-7	2.47E-5
ENSG00000090487	SPG21	1.836517969	1.11E-5	4.9608E-4
ENSG00000134278	SPIRE1	1.918477263	2.34E-6	1.34509E-4
ENSG00000118785	SPP1	5.958987591	1.51E-10	2.77E-8
ENSG00000187678	SPRY4	2.157448069	1.44E-6	8.94E-5
ENSG00000070182	SPTB	-3.208665586	1.61E-5	6.83636E-4
ENSG00000172296	SPTLC3	-2.858521332	1.75E-6	1.06313E-4
ENSG00000134548	SPX	-5.475379293	6.2E-5	0.002097059
ENSG00000161011	SQSTM1	3.538624572	6.98E-22	4.91E-19
ENSG00000213523	SRA1	2.078780589	2.84135E-4	0.007163947
ENSG00000072310	SREBF1	1.980104395	9.67E-6	4.42759E-4
ENSG00000198911	SREBF2	1.955870431	1.64346E-4	0.004608164
ENSG00000196935	SRGAP1	2.51633672	2.69E-14	8.8E-12
ENSG00000116649	SRM	3.467116727	1.15E-14	3.98E-12
ENSG00000182934	SRPRA	1.823271665	3.79E-6	2.03674E-4
ENSG00000144867	SRPRB	2.481556316	1.99E-7	1.62E-5
ENSG00000101955	SRPX	1.96138997	1.80264E-4	0.004952738
ENSG00000102359	SRPX2	1.7441273	2.94403E-4	0.007383884
ENSG00000167720	SRR	2.231592779	3.86651E-4	0.009113852
ENSG00000180879	SSR4	2.150961652	1.65E-5	6.9696E-4
ENSG00000160075	SSU72	2.138737729	1.39E-6	8.67E-5
ENSG00000064225	ST3GAL6	-2.503395425	7.27E-6	3.53907E-4
ENSG00000070731	ST6GALNAC2	1.920677806	7.86E-5	0.002548716
ENSG00000184005	ST6GALNAC3	-2.559126544	9.67E-5	0.003015231
ENSG00000136840	ST6GALNAC4	4.327616791	4.88E-6	2.53044E-4
ENSG00000010327	STAB1	1.918969844	7.44E-5	0.002436451
ENSG00000106610	STAG3L4	2.381168472	4.18E-6	2.217E-4
ENSG00000136738	STAM	2.750172227	2.04E-11	4.24E-9
ENSG00000084090	STARD7	2.490528048	8.88E-10	1.4E-7
ENSG00000113739	STC2	3.010371688	4.37E-7	3.23E-5
ENSG00000115107	STEAP3	2.442939883	1.76E-8	2.0E-6
ENSG00000167323	STIM1	2.094843935	1.39E-6	8.67E-5
ENSG00000168439	STIP1	2.652835648	1.36E-12	3.42E-10
ENSG00000198648	STK39	3.061488308	3.13E-9	4.38E-7
ENSG00000196182	STK40	3.0936183	1.29E-14	4.43E-12
ENSG00000165283	STOML2	2.2470124	1.47E-5	6.30666E-4
ENSG00000243244	STON1	-2.695845903	6.37E-7	4.51E-5
ENSG00000090372	STRN4	2.076935577	3.18243E-4	0.00787841
ENSG00000101846	STS	1.678641139	2.95791E-4	0.007410913
ENSG00000134910	STT3A	1.763419011	1.52422E-4	0.004321989
ENSG00000163527	STT3B	1.826755602	1.74E-5	7.30753E-4
ENSG00000103266	STUB1	2.195482444	2.38E-5	9.42842E-4
ENSG00000104915	STX10	2.254476393	3.60393E-4	0.008635511
ENSG00000136854	STXBP1	2.37946594	3.24E-9	4.49E-7
ENSG00000166263	STXBP4	1.976136385	2.07953E-4	0.005549039
ENSG00000164506	STXBP5	1.810292193	1.16925E-4	0.003511353
ENSG00000168952	STXBP6	-4.642448771	8.23E-9	1.01E-6
ENSG00000137573	SULF1	-2.612348907	6.81E-5	0.002272139
ENSG00000184900	SUMO3	2.005493045	6.09E-7	4.34E-5
ENSG00000156502	SUPV3L1	2.281425766	3.5E-9	4.79E-7
ENSG00000148290	SURF1	2.834890247	3.37E-6	1.85027E-4
ENSG00000185518	SV2B	-3.503762512	1.93E-6	1.15225E-4
ENSG00000224597	SVIL-AS1	1.761209063	1.72E-5	7.21866E-4
ENSG00000108639	SYNGR2	1.957287662	3.74E-5	0.001377561
ENSG00000261054	SYNM	3.460159986	1.07E-17	5.46E-15
ENSG00000172403	SYNPO2	-2.128081654	3.32E-5	0.00125157
ENSG00000008282	SYPL1	1.864294477	7.91E-5	0.002560683
ENSG00000132718	SYT11	-1.97528101	1.21514E-4	0.00361508
ENSG00000103528	SYT17	-2.55349068	6.69E-5	0.002239014
ENSG00000143858	SYT2	-3.103192985	9.68E-7	6.35E-5
ENSG00000055070	SZRD1	2.15084941	1.84E-7	1.52E-5
ENSG00000115353	TACR1	-3.383571511	2.13E-5	8.60892E-4
ENSG00000166337	TAF10	1.825176645	1.36307E-4	0.003983244
ENSG00000197780	TAF13	2.432765413	9.02E-6	4.18785E-4
ENSG00000106290	TAF6	1.899030379	1.7121E-4	0.004753283
ENSG00000177156	TALDO1	2.767321637	7.06E-8	6.52E-6
ENSG00000183597	TANGO2	1.960767815	7.99E-5	0.002587132
ENSG00000113407	TARS	2.802445454	9.7E-14	2.92E-11
ENSG00000213977	TAX1BP3	3.077219382	2.42E-5	9.55191E-4
ENSG00000108239	TBC1D12	-2.126831001	4.23655E-4	0.009812317
ENSG00000107021	TBC1D13	1.748792922	2.27324E-4	0.005964481
ENSG00000167291	TBC1D16	1.780076892	7.0E-5	0.002325179
ENSG00000167202	TBC1D2B	1.540548459	3.07467E-4	0.007647301
ENSG00000145979	TBC1D7	2.169330539	4.68E-5	0.00166177
ENSG00000171530	TBCA	2.653973849	3.05E-6	1.69569E-4
ENSG00000092377	TBL1Y	7.30947785	2.4E-11	4.91E-9
ENSG00000187735	TCEA1	3.473643752	2.15E-14	7.13E-12
ENSG00000103363	TCEB2	2.218190526	1.17E-5	5.22304E-4
ENSG00000081059	TCF7	2.154827147	9.35E-6	4.31038E-4
ENSG00000120438	TCP1	1.960912165	2.57E-6	1.46781E-4
ENSG00000099797	TECR	2.37836352	2.31E-6	1.33247E-4
ENSG00000188681	TEKT4P2	-3.057827361	2.69E-5	0.001044852
ENSG00000149256	TENM4	6.423637744	6.62E-32	9.31E-29
ENSG00000107140	TESK1	2.150095161	1.12181E-4	0.003398807
ENSG00000112561	TFEB	2.094056066	5.95E-5	0.002026223
ENSG00000003436	TFPI	-1.71168164	5.1E-5	0.001775431
ENSG00000072274	TFRC	2.169114876	1.44E-6	8.95E-5
ENSG00000092969	TGFB2	6.388916712	2.09E-27	2.12E-24
ENSG00000168286	THAP11	2.064641001	3.29894E-4	0.008095527
ENSG00000137801	THBS1	-4.659960458	2.86E-5	0.00110493
ENSG00000130193	THEM6	2.99426639	6.45E-11	1.27E-8
ENSG00000130775	THEMIS2	2.858117327	1.79E-8	2.03E-6
ENSG00000126351	THRA	1.719137645	9.12E-5	0.002879329
ENSG00000151365	THRSP	2.406243826	1.41E-5	6.07894E-4
ENSG00000187720	THSD4	-6.169036655	1.84E-5	7.6357E-4
ENSG00000134077	THUMPD3	2.094854717	1.96E-6	1.16666E-4
ENSG00000151923	TIAL1	1.657232504	2.43291E-4	0.00632094
ENSG00000066056	TIE1	-1.841369302	2.57642E-4	0.006614661
ENSG00000181847	TIGIT	-3.370572823	1.0E-5	4.55439E-4
ENSG00000134809	TIMM10	2.89045868	5.71E-6	2.89981E-4
ENSG00000099800	TIMM13	3.419032305	7.61E-10	1.23E-7
ENSG00000150779	TIMM8B	2.94681118	1.15E-7	1.01E-5
ENSG00000143155	TIPRL	2.149691688	1.11253E-4	0.003379256
ENSG00000163931	TKT	2.175689195	1.20203E-4	0.003596231
ENSG00000171914	TLN2	1.874530503	1.68937E-4	0.004709234
ENSG00000139644	TMBIM6	1.825021312	1.0557E-4	0.003230104
ENSG00000149488	TMC2	-3.115240086	1.22E-5	5.37818E-4
ENSG00000103534	TMC5	-4.095046174	2.95588E-4	0.007409693
ENSG00000099203	TMED1	2.521844922	1.92884E-4	0.005224379
ENSG00000166557	TMED3	2.387851305	7.17E-5	0.002367099
ENSG00000109066	TMEM104	1.762854671	4.33168E-4	0.009964535
ENSG00000178307	TMEM11	2.19515946	5.99E-5	0.002034256
ENSG00000152558	TMEM123	2.505643046	5.87E-8	5.56E-6
ENSG00000171204	TMEM126B	1.870647184	3.32872E-4	0.008147678
ENSG00000135956	TMEM127	2.020960288	4.69E-8	4.61E-6
ENSG00000168936	TMEM129	1.959208441	3.95825E-4	0.009288341
ENSG00000181234	TMEM132C	-2.660656119	1.65E-5	6.9696E-4
ENSG00000105677	TMEM147	3.18602169	1.6E-12	3.97E-10
ENSG00000111843	TMEM14C	2.117418201	5.35E-6	2.74558E-4
ENSG00000002933	TMEM176A	2.926169778	2.01E-9	2.94E-7
ENSG00000106565	TMEM176B	2.704494471	3.61E-6	1.95423E-4
ENSG00000198792	TMEM184B	2.030750107	2.19E-7	1.76E-5
ENSG00000240849	TMEM189	2.073782758	8.0E-6	3.78492E-4
ENSG00000135048	TMEM2	-1.809985301	2.09745E-4	0.005587083
ENSG00000188807	TMEM201	2.37010004	1.74E-5	7.30558E-4
ENSG00000105518	TMEM205	2.25585269	1.81E-5	7.56383E-4
ENSG00000168701	TMEM208	2.669386289	4.42E-6	2.33266E-4
ENSG00000109133	TMEM33	1.679168912	1.01E-5	4.55825E-4
ENSG00000170876	TMEM43	1.787764016	1.3807E-4	0.004027371
ENSG00000135211	TMEM60	2.082824479	4.7E-5	0.001666096
ENSG00000129925	TMEM8A	2.800881956	6.24E-6	3.13035E-4
ENSG00000175348	TMEM9B	2.371539065	1.16E-9	1.76E-7
ENSG00000136842	TMOD1	-4.573460256	3.69E-8	3.74E-6
ENSG00000205542	TMSB10/TMSB4X	1.896357642	4.47E-6	2.34895E-4
ENSG00000154620	TMSB4Y	23.51760641	2.33E-5	9.25172E-4
ENSG00000213593	TMX2	2.35486347	7.36E-6	3.57048E-4
ENSG00000163154	TNFAIP8L2	5.204774146	1.02579E-4	0.003162025
ENSG00000006327	TNFRSF12A	7.734298072	1.22E-8	1.44E-6
ENSG00000067182	TNFRSF1A	1.724588545	1.9191E-4	0.005200956
ENSG00000083312	TNPO1	1.742246657	1.72E-5	7.21866E-4
ENSG00000079308	TNS1	-2.340585593	2.77E-5	0.001074768
ENSG00000168477	TNXB	-3.05170082	1.0E-5	4.54276E-4
ENSG00000078902	TOLLIP	2.012129577	2.0E-6	1.18669E-4
ENSG00000100216	TOMM22	2.086463043	2.39E-5	9.43389E-4
ENSG00000175768	TOMM5	1.988380002	5.19E-6	2.67998E-4
ENSG00000214736	TOMM6	2.04549315	4.86E-5	0.001700405
ENSG00000131747	TOP2A	6.93157698	1.14E-11	2.47E-9
ENSG00000073282	TP63	-4.135027861	3.93661E-4	0.009256267
ENSG00000143549	TPM3	1.74007163	3.91E-5	0.001432601
ENSG00000115705	TPO	-4.524306212	2.88E-5	0.001108335
ENSG00000166340	TPP1	2.141533461	1.1E-7	9.68E-6
ENSG00000159713	TPPP3	-4.117541827	4.16E-6	2.20949E-4
ENSG00000172236	TPSAB1/TPSB2	3.984129299	4.96E-7	3.62E-5
ENSG00000128294	TPST2	2.736706505	3.72E-8	3.76E-6
ENSG00000186854	TRABD2A	-2.570797861	1.25E-6	7.88E-5
ENSG00000131323	TRAF3	2.934388032	6.04E-14	1.9E-11
ENSG00000231889	TRAF3IP2-AS1	-2.266270255	2.69054E-4	0.006845117
ENSG00000131653	TRAF7	2.609737305	2.78797E-4	0.007055414
ENSG00000181029	TRAPPC5	3.434831743	3.29E-8	3.37E-6
ENSG00000211772	TRBC2	2.596792034	2.41825E-4	0.006286267
ENSG00000095970	TREM2	5.787306838	2.75E-6	1.54739E-4
ENSG00000101255	TRIB3	16.6890179	8.7E-111	4.16E-106
ENSG00000221926	TRIM16	2.531845177	4.7E-9	6.14E-7
ENSG00000109654	TRIM2	1.748413534	1.50831E-4	0.004299842
ENSG00000130726	TRIM28	1.994599371	2.13E-5	8.60892E-4
ENSG00000104228	TRIM35	2.043293961	4.33849E-4	0.009975397
ENSG00000147573	TRIM55	-10.49329795	3.36E-7	2.6E-5
ENSG00000100106	TRIOBP	2.238519546	6.08E-9	7.75E-7
ENSG00000145331	TRMT10A	2.801191971	2.13E-5	8.60892E-4
ENSG00000174173	TRMT10C	2.225714326	2.40931E-4	0.006269853
ENSG00000173113	TRMT112	2.181848003	1.95E-6	1.16044E-4
ENSG00000104321	TRPA1	3.844765428	8.64E-10	1.37E-7
ENSG00000167112	TRUB2	2.258798597	1.83E-6	1.10181E-4
ENSG00000196428	TSC22D2	1.803630068	3.49586E-4	0.008465729
ENSG00000198860	TSEN15	2.195158701	1.15275E-4	0.003472705
ENSG00000211460	TSN	1.851721204	3.71E-5	0.001368182
ENSG00000158457	TSPAN33	3.641263941	3.35E-5	0.001260087
ENSG00000100300	TSPO	2.020047259	5.97E-5	0.00203027
ENSG00000007520	TSR3	2.465946598	1.1E-7	9.67E-6
ENSG00000113312	TTC1	2.095430418	8.23E-7	5.56E-5
ENSG00000103852	TTC23	2.149845956	6.8E-10	1.1E-7
ENSG00000165914	TTC7B	1.877739459	4.55E-5	0.001625313
ENSG00000114999	TTL	1.936838707	4.71E-5	0.001666328
ENSG00000135912	TTLL4	1.960008779	5.75E-6	2.91184E-4
ENSG00000229236	TTTY10	18.09204188	3.9E-13	1.04E-10
ENSG00000176728	TTTY14	13.36806156	1.21E-13	3.57E-11
ENSG00000233864	TTTY15	3.417887127	1.38648E-4	0.004041762
ENSG00000136295	TTYH3	2.856825772	3.38E-11	6.82E-9
ENSG00000166402	TUB	4.363617398	2.38E-18	1.32E-15
ENSG00000123416	TUBA1B	2.153236425	1.77E-6	1.07031E-4
ENSG00000167553	TUBA1C	3.489183964	6.95E-12	1.59E-9
ENSG00000196230	TUBB	2.372812019	3.96E-8	3.97E-6
ENSG00000137267	TUBB2A	2.83141727	3.06E-12	7.32E-10
ENSG00000188229	TUBB4B	2.788441339	4.23E-9	5.6E-7
ENSG00000131462	TUBG1	2.322504255	1.03E-6	6.69E-5
ENSG00000151239	TWF1	2.151362276	1.51493E-4	0.004308437
ENSG00000247596	TWF2	2.093798847	3.55113E-4	0.008534684
ENSG00000131002	TXLNGY	23.53485695	3.18E-37	6.92E-34
ENSG00000136810	TXN	3.635158274	2.6E-22	1.89E-19
ENSG00000100348	TXN2	1.984956382	9.66E-6	4.42759E-4
ENSG00000117862	TXNDC12	3.467952116	1.62E-21	1.1E-18
ENSG00000091164	TXNL1	1.694791621	6.37E-6	3.18538E-4
ENSG00000141759	TXNL4A	2.125071599	3.84071E-4	0.009070941
ENSG00000198431	TXNRD1	2.689879644	2.51E-13	6.85E-11
ENSG00000025708	TYMP	2.166822468	9.02E-6	4.18785E-4
ENSG00000011600	TYROBP	4.085702411	1.6E-12	3.97E-10
ENSG00000081307	UBA5	1.90046736	4.3481E-4	0.009992676
ENSG00000221983	UBA52	1.995022833	7.25E-6	3.53089E-4
ENSG00000185262	UBALD2	1.957274952	2.55203E-4	0.006566146
ENSG00000077721	UBE2A	1.765716786	3.43176E-4	0.008326778
ENSG00000131508	UBE2D2	2.356873206	9.52E-9	1.14E-6
ENSG00000170142	UBE2E1	2.140793976	1.06126E-4	0.003241613
ENSG00000184182	UBE2F	2.272448594	2.75E-6	1.54812E-4
ENSG00000103275	UBE2I	1.751803722	1.17493E-4	0.003521989
ENSG00000078140	UBE2K	1.804797001	2.69421E-4	0.006850819
ENSG00000120942	UBIAD1	1.845485256	6.84E-5	0.002277355
ENSG00000102178	UBL4A	2.768057953	2.28E-5	9.10148E-4
ENSG00000198258	UBL5	1.917821281	6.17E-6	3.09748E-4
ENSG00000135018	UBQLN1	1.92678755	1.83E-5	7.61024E-4
ENSG00000162191	UBXN1	1.904707227	2.48475E-4	0.006431153
ENSG00000158062	UBXN11	2.158580948	1.13E-5	5.05712E-4
ENSG00000154277	UCHL1	5.388574398	2.78E-29	3.24E-26
ENSG00000175567	UCP2	2.768026691	2.12E-6	1.24631E-4
ENSG00000148154	UGCG	2.726375649	5.34E-6	2.74378E-4
ENSG00000152332	UHMK1	1.885556493	1.23E-5	5.44555E-4
ENSG00000111647	UHRF1BP1L	1.72610663	2.1817E-4	0.00576545
ENSG00000107731	UNC5B	13.43604918	8.49E-109	2.03E-104
ENSG00000076248	UNG	2.582495264	1.87E-7	1.54E-5
ENSG00000137288	UQCC2	4.424988524	1.11E-9	1.69E-7
ENSG00000184076	UQCR10	2.602771933	2.67E-5	0.001038972
ENSG00000127540	UQCR11	2.429359227	1.67E-5	7.03969E-4
ENSG00000010256	UQCRC1	1.922438355	3.71713E-4	0.008871157
ENSG00000169021	UQCRFS1	2.215481661	2.95E-6	1.64488E-4
ENSG00000173660	UQCRH	1.831891324	2.22708E-4	0.005866174
ENSG00000164405	UQCRQ	2.554479738	1.56E-7	1.31E-5
ENSG00000142207	URB1	2.189053819	3.47E-9	4.76E-7
ENSG00000188690	UROS	2.587664455	2.42E-7	1.93E-5
ENSG00000173915	USMG5	1.847664287	4.11143E-4	0.009573111
ENSG00000184979	USP18	-3.640842687	5.39E-5	0.001855982
ENSG00000124422	USP22	1.786639484	1.175E-4	0.003521989
ENSG00000111667	USP5	2.425761882	6.41E-7	4.53E-5
ENSG00000114374	USP9Y	11.35923595	3.65E-32	5.29E-29
ENSG00000111962	UST	1.90238564	2.33759E-4	0.006113184
ENSG00000183520	UTP11L	1.822002274	4.56E-5	0.001625556
ENSG00000164338	UTP15	2.032555161	4.14E-5	0.001499422
ENSG00000141076	UTP4	1.924701146	4.21E-7	3.14E-5
ENSG00000183878	UTY	12.01755321	6.2E-53	2.96E-49
ENSG00000115652	UXS1	2.078951634	4.81E-5	0.001692028
ENSG00000103043	VAC14	2.14692578	1.63E-8	1.88E-6
ENSG00000168899	VAMP5	2.25234427	2.97847E-4	0.007446811
ENSG00000173218	VANGL1	2.536588062	3.66E-7	2.79E-5
ENSG00000101558	VAPA	2.341819065	1.18E-9	1.78E-7
ENSG00000108828	VAT1	2.751981203	7.4E-12	1.68E-9
ENSG00000162692	VCAM1	2.925838638	2.5E-8	2.7E-6
ENSG00000213585	VDAC1	2.373130534	3.18E-9	4.42E-7
ENSG00000165637	VDAC2	2.013361044	9.47E-5	0.002958822
ENSG00000205221	VIT	-2.354596161	3.52662E-4	0.008501438
ENSG00000167397	VKORC1	2.161536252	5.62E-6	2.86071E-4
ENSG00000160695	VPS11	1.595581356	3.97824E-4	0.009312901
ENSG00000160948	VPS28	1.803209226	3.77173E-4	0.00895674
ENSG00000132612	VPS4A	1.90708526	7.07E-5	0.002343085
ENSG00000155659	VSIG4	2.950150367	1.32E-7	1.13E-5
ENSG00000110002	VWA5A	1.686468263	4.3176E-4	0.009936918
ENSG00000140105	WARS	4.230582332	5.19E-24	4.68E-21
ENSG00000116874	WARS2	2.38089221	4.09057E-4	0.009538482
ENSG00000132471	WBP2	2.178440832	7.18E-7	4.98E-5
ENSG00000071127	WDR1	1.748031083	1.66E-5	7.01562E-4
ENSG00000138442	WDR12	2.172409466	1.47271E-4	0.004231198
ENSG00000065268	WDR18	2.782652645	3.9E-5	0.001430863
ENSG00000140395	WDR61	1.72473621	4.17281E-4	0.009706566
ENSG00000105583	WDR83OS	1.770459409	2.84515E-4	0.007169754
ENSG00000140527	WDR93	-3.278990988	3.18711E-4	0.007885909
ENSG00000109685	WHSC1	1.712322654	2.48E-5	9.74499E-4
ENSG00000122574	WIPF3	3.470503419	1.19E-7	1.04E-5
ENSG00000111186	WNT5B	3.048231844	1.37494E-4	0.004013035
ENSG00000109046	WSB1	1.735288541	2.9E-5	0.001113122
ENSG00000176871	WSB2	3.263036611	6.38E-17	2.92E-14
ENSG00000229807	XIST	-11.15298327	3.07E-31	4.07E-28
ENSG00000122121	XPNPEP2	2.505654139	2.88E-5	0.001108335
ENSG00000124571	XPO5	2.110630315	5.01E-7	3.64E-5
ENSG00000169180	XPO6	2.023423631	2.27E-6	1.31123E-4
ENSG00000184575	XPOT	4.342076524	2.11E-38	4.79E-35
ENSG00000196419	XRCC6	1.780630271	1.39661E-4	0.00406138
ENSG00000103489	XYLT1	3.215778223	3.6E-15	1.32E-12
ENSG00000134684	YARS	2.586404312	1.3E-14	4.45E-12
ENSG00000139131	YARS2	2.282932974	8.13E-5	0.002620878
ENSG00000174851	YIF1A	2.071240872	6.99E-5	0.002322768
ENSG00000130733	YIPF2	2.266239095	6.7E-6	3.2979E-4
ENSG00000100027	YPEL1	-1.905461294	2.74257E-4	0.006955267
ENSG00000166913	YWHAB	1.736556591	1.73556E-4	0.004800569
ENSG00000170027	YWHAG	1.95935926	3.65E-5	0.001349884
ENSG00000221886	ZBED8	2.725421107	3.01239E-4	0.007515885
ENSG00000109906	ZBTB16	-2.767723168	1.35036E-4	0.003955082
ENSG00000114853	ZBTB47	2.230041351	1.26572E-4	0.003753858
ENSG00000160685	ZBTB7B	2.09209034	6.79E-6	3.33954E-4
ENSG00000184828	ZBTB7C	-6.441383036	2.37E-8	2.58E-6
ENSG00000100403	ZC3H7B	2.064345032	5.67E-5	0.001935032
ENSG00000206077	ZDHHC11B	-6.406048789	1.77E-5	7.39702E-4
ENSG00000156639	ZFAND3	3.050822716	2.64E-14	8.69E-12
ENSG00000177410	ZFAS1	2.717679108	5.64E-8	5.39E-6
ENSG00000067646	ZFY	47.63430327	1.08E-23	9.4E-21
ENSG00000152926	ZNF117	3.309716123	1.96E-15	7.38E-13
ENSG00000165804	ZNF219	1.948579153	7.4E-5	0.002426494
ENSG00000109445	ZNF330	2.298490779	5.54E-9	7.15E-7
ENSG00000198816	ZNF358	2.034553808	3.78641E-4	0.008973763
ENSG00000160094	ZNF362	2.010960231	8.0E-5	0.00258847
ENSG00000133250	ZNF414	3.336442098	6.39E-6	3.19208E-4
ENSG00000173258	ZNF483	-2.016145293	2.26606E-4	0.005948912
ENSG00000166716	ZNF592	1.894726441	2.22E-6	1.28991E-4
ENSG00000196458	ZNF605	1.76459989	2.06743E-4	0.005531284
ENSG00000166770	ZNF667-AS1	2.052190633	1.3E-5	5.66201E-4
ENSG00000187792	ZNF70	1.703388677	4.31355E-4	0.009936918
ENSG00000169957	ZNF768	2.179043635	2.73778E-4	0.006946806
ENSG00000142409	ZNF787	2.632601064	5.57E-5	0.001906768
ENSG00000196152	ZNF79	3.119580819	9.24E-5	0.002900463
ENSG00000217896	ZNF839P1	42.8945273	2.94E-13	7.94E-11
ENSG00000109917	ZPR1	2.000559326	7.64E-7	5.24E-5

