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Ingenuity Pathway Analysis Results for P2

Analysis Details for My Projects->David Bulger->P2
Workspace	My Projects
Project	David Bulger
Analysis	P2
Date	Mon May 16 10:34:50 PDT 2016
Analysis ID	13377528

Analysis Settings
Cutoff before duplicate resolution	true
Resolve duplicate on	Expression foldchange
Color using	Expression foldchange
Cutoff for Expression foldchange	1.5	and consider Both up/down regulated
Cutoff for Expression pvalue	--
Cutoff for Expression qvalue	0.01
Reference set	Ingenuity Knowledge Base (Genes Only)
Relationship to include	Direct and Indirect
Includes Endogenous Chemicals	Yes
Optional Analyses	My Pathways My List
Filter Summary	
Consider only molecules and/or relationships where
(confidence = Experimentally Observed) AND
(mol. types = biologic drug OR chemical - endogenous mammalian OR chemical - endogenous non-mammalian OR chemical - kinase inhibitor OR chemical - other OR chemical - protease inhibitor OR chemical drug OR chemical reagent OR chemical toxicant OR complex OR cytokine OR disease OR enzyme OR function OR G-protein coupled receptor OR group OR growth factor OR ion channel OR kinase OR ligand-dependent nuclear receptor OR mature microRNA OR microRNA OR other OR peptidase OR phosphatase OR transcription regulator OR translation regulator OR transmembrane receptor OR transporter)

Canonical Pathways for My Projects->David Bulger->P2
Ingenuity Canonical Pathways	 -log(p-value)	zScore	Ratio	Molecules
Acute Myeloid Leukemia Signaling	-0E00	0.8164965809277261	7.59E-02	PIK3R3,PIK3R1,PIK3CG,KIT,HRAS,CSF1R	
Agranulocyte Adhesion and Diapedesis	-0E00	NaN	6.35E-02	MYL9,CXCL10,CXCL16,ITGB2,VCAM1,IL1RN,CLDN1,CCL28,CXCL14,SDC4,CXCL9,ACTG1	
Angiopoietin Signaling	-0E00	NaN	7.58E-02	PIK3R3,ANGPTL1,PIK3R1,PIK3CG,HRAS	
Antiproliferative Role of TOB in T Cell Signaling	-0E00	NaN	7.69E-02	TGFBR1,TGFB2	
Assembly of RNA Polymerase III Complex	-0E00	NaN	7.69E-02	BRF2,	
BMP signaling pathway	-0E00	1.3416407864998738	6.58E-02	PRKACB,JUN,MAPK10,HRAS,MAPK9	
Bladder Cancer Signaling	-0E00	NaN	6.90E-02	TP53,THBS1,FGF2,HRAS,PDGFC,FGF1	
CDP-diacylglycerol Biosynthesis I	-0E00	NaN	6.25E-02	AGPAT1,	
Calcium Signaling	-0E00	2.23606797749979	5.62E-02	MYL9,PRKACB,CALM1 (includes others),RAP2A,CAMK2D,LETM1,ATP2B1,ATF4,TPM3,ASPH	
Cell Cycle Control of Chromosomal Replication	-0E00	NaN	7.41E-02	RPA4,ORC5	
Cell Cycle: G1/S Checkpoint Regulation	-0E00	0.0	7.81E-02	TP53,CCND2,CCND3,TGFB2,GNL3	
Cholesterol Biosynthesis I	-0E00	NaN	7.69E-02	MSMO1,	
Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)	-0E00	NaN	7.69E-02	MSMO1,	
Cholesterol Biosynthesis III (via Desmosterol)	-0E00	NaN	7.69E-02	MSMO1,	
Coagulation System	-0E00	NaN	2.86E-02	F13A1,	
Cyclins and Cell Cycle Regulation	-0E00	-0.8164965809277261	7.69E-02	TP53,CCND2,CCND3,PTPA,TGFB2,PPP2R1B	
DNA Methylation and Transcriptional Repression Signaling	-0E00	NaN	5.00E-02	MBD3,	
DNA damage-induced 14-3-3σ Signaling	-0E00	NaN	5.26E-02	TP53,	
Death Receptor Signaling	-0E00	1.889822365046136	7.61E-02	TNFRSF10B,CYCS,ACTG1,MAP4K4,ARHGDIB,FAS,HSPB1	
Eicosanoid Signaling	-0E00	NaN	7.81E-02	PTGFR,AKR1C3,ALOX5AP,RARRES3,PLA2G2A	
Estrogen-mediated S-phase Entry	-0E00	NaN	4.17E-02	ESR2,	
Extrinsic Prothrombin Activation Pathway	-0E00	NaN	6.25E-02	F13A1,	
Factors Promoting Cardiogenesis in Vertebrates	-0E00	NaN	4.35E-02	TGFBR1,DVL1,TGFB2,ACVR1C	
Fatty Acid Activation	-0E00	NaN	7.69E-02	ACSL3,	
Fatty Acid β-oxidation I	-0E00	NaN	6.25E-02	ACSL3,HADHB	
Glutathione-mediated Detoxification	-0E00	NaN	3.45E-02	GSTP1,	
Granulocyte Adhesion and Diapedesis	-0E00	NaN	7.34E-02	CXCL10,CXCL16,FPR3,ITGB2,VCAM1,IL1RN,CLDN1,CCL28,CXCL14,SDC4,SDC3,CXCL9,HSPB1	
Granzyme B Signaling	-0E00	NaN	6.25E-02	CYCS,	
Guanosine Nucleotides Degradation III	-0E00	NaN	7.69E-02	AOX1,	
HER-2 Signaling in Breast Cancer	-0E00	NaN	7.89E-02	TP53,PIK3R3,ITGB2,PIK3R1,PIK3CG,HRAS	
IL-15 Production	-0E00	NaN	3.70E-02	STAT1,	
Inhibition of Matrix Metalloproteases	-0E00	NaN	7.69E-02	ADAM17,ADAM12,TIMP1	
Interferon Signaling	-0E00	NaN	5.56E-02	STAT1,ISG15	
Intrinsic Prothrombin Activation Pathway	-0E00	NaN	6.90E-02	COL5A3,F13A1	
Leukocyte Extravasation Signaling	-0E00	1.9414506867883021	7.58E-02	VCAM1,PIK3R1,RAC1,CTNNA1,MAPK9,PIK3R3,ITGB2,TIMP1,CLDN1,PIK3CG,MAPK10,CYBB,ARHGAP35,ACTG1,ACTN1	
Mechanisms of Viral Exit from Host Cells	-0E00	NaN	4.88E-02	SH3GLB1,ACTG1	
Melatonin Degradation I	-0E00	NaN	5.26E-02	POR,CYP3A5,CYP4B1	
Mismatch Repair in Eukaryotes	-0E00	NaN	6.25E-02	SLC19A1,	
Mitochondrial L-carnitine Shuttle Pathway	-0E00	NaN	5.88E-02	ACSL3,	
Mitotic Roles of Polo-Like Kinase	-0E00	NaN	4.55E-02	PTPA,ANAPC11,PPP2R1B	
Mouse Embryonic Stem Cell Pluripotency	-0E00	1.1338934190276817	7.37E-02	TP53,PIK3R3,PIK3R1,PIK3CG,DVL1,HRAS,DVL3	
NAD Phosphorylation and Dephosphorylation	-0E00	NaN	7.69E-02	ACP2,	
NAD Salvage Pathway II	-0E00	NaN	7.69E-02	ACP2,NMNAT2	
NAD biosynthesis II (from tryptophan)	-0E00	NaN	6.67E-02	NMNAT2,	
Neuregulin Signaling	-0E00	NaN	4.55E-02	PIK3R3,ADAM17,PIK3R1,HRAS	
Nicotine Degradation III	-0E00	NaN	7.41E-02	POR,CYP3A5,CYP4B1,AOX1	
Non-Small Cell Lung Cancer Signaling	-0E00	0.4472135954999579	7.69E-02	TP53,PIK3R3,PIK3R1,PIK3CG,HRAS	
Oleate Biosynthesis II (Animals)	-0E00	NaN	7.69E-02	SCD,	
Oncostatin M Signaling	-0E00	NaN	5.88E-02	HRAS,STAT1	
PPARα/RXRα Activation	-0E00	-1.507556722888818	7.91E-02	PRKACB,PLCB2,ADCY2,TGFBR1,ADIPOQ,HRAS,AIP,JUN,PLCE1,ADCY1,TGFB2,INSR,MAP4K4,ACVR1C	
Phosphatidylglycerol Biosynthesis II (Non-plastidic)	-0E00	NaN	5.56E-02	AGPAT1,	
Phototransduction Pathway	-0E00	NaN	3.77E-02	GNB1,PRKACB	
Pyridoxal 5'-phosphate Salvage Pathway	-0E00	NaN	6.25E-02	CSNK1A1,MAPK9,PKN1,IRAK1	
Retinoate Biosynthesis I	-0E00	NaN	3.03E-02	AKR1C3,	
Retinoic acid Mediated Apoptosis Signaling	-0E00	NaN	3.28E-02	TNFRSF10B,CYCS	
Retinol Biosynthesis	-0E00	NaN	5.88E-02	CES1,CES2	
Role of BRCA1 in DNA Damage Response	-0E00	NaN	7.69E-02	TP53,FANCE,BARD1,SLC19A1,STAT1,HLTF	
Role of CHK Proteins in Cell Cycle Checkpoint Control	-0E00	NaN	7.27E-02	TP53,PTPA,SLC19A1,PPP2R1B	
Role of Cytokines in Mediating Communication between Immune Cells	-0E00	NaN	1.85E-02	IL1RN,	
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza	-0E00	NaN	6.98E-02	CCR1,CXCL10,IL1RN	
Role of IL-17F in Allergic Inflammatory Airway Diseases	-0E00	NaN	6.82E-02	CXCL10,ATF4,IL17RA	
Role of JAK1, JAK2 and TYK2 in Interferon Signaling	-0E00	NaN	4.17E-02	STAT1,	
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency	-0E00	-0.4472135954999579	6.31E-02	TP53,PIK3R3,PIK3R1,PIK3CG,DVL1,HRAS,WNT5B	
Role of PI3K/AKT Signaling in the Pathogenesis of Influenza	-0E00	NaN	4.76E-02	PIK3R3,PIK3R1,PIK3CG	
Role of RIG1-like Receptors in Antiviral Innate Immunity	-0E00	NaN	2.33E-02	TRAF3,	
Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza	-0E00	NaN	5.26E-02	DVL1,CSNK1A1,DVL3,WNT5B	
Serotonin Degradation	-0E00	NaN	4.48E-02	ALDH2,ALDH4A1,ALDH3A2	
Serotonin Receptor Signaling	-0E00	NaN	4.55E-02	ADCY2,ADCY1	
Sonic Hedgehog Signaling	-0E00	NaN	6.67E-02	PRKACB,GLIS2	
Sperm Motility	-0E00	1.889822365046136	6.61E-02	PRKACB,CALM1 (includes others),PLCB2,PLCE1,SLC12A2,RARRES3,PLA2G2A,PDE1C	
Superpathway of Citrulline Metabolism	-0E00	NaN	7.14E-02	ASS1,	
Superpathway of Melatonin Degradation	-0E00	NaN	4.84E-02	POR,CYP3A5,CYP4B1	
Synaptic Long Term Depression	-0E00	0.7071067811865475	5.63E-02	PLCB2,PLCE1,PTPA,GNA12,HRAS,RARRES3,PPP2R1B,PLA2G2A	
TNFR1 Signaling	-0E00	NaN	6.12E-02	FOS,JUN,CYCS	
TNFR2 Signaling	-0E00	NaN	6.90E-02	FOS,JUN	
TREM1 Signaling	-0E00	2.23606797749979	6.67E-02	TYROBP,TLR8,CD83,NLRC4,IRAK1	
Triacylglycerol Degradation	-0E00	NaN	4.00E-02	CES1,	
Tryptophan Degradation III (Eukaryotic)	-0E00	NaN	4.76E-02	HADHB,	
Ubiquinol-10 Biosynthesis (Eukaryotic)	-0E00	NaN	7.14E-02	CYP4F11,	
Urate Biosynthesis/Inosine 5'-phosphate Degradation	-0E00	NaN	7.14E-02	AOX1,	
VEGF Family Ligand-Receptor Interactions	-0E00	0.8164965809277261	7.89E-02	PIK3R3,FOS,PIK3R1,PIK3CG,HRAS,PLA2G2A	
cAMP-mediated signaling	-0E00	0.0	7.31E-02	PRKACB,ADCY2,NPY1R,DUSP6,LHCGR,PDE1C,CALM1 (includes others),CAMK2D,NPR3,ADCY1,ATF4,P2RY12,PDE8B,DUSP4,ADORA1,HCAR2	
tRNA Splicing	-0E00	NaN	5.71E-02	PDE8B,PDE1C	
γ-linolenate Biosynthesis II (Animals)	-0E00	NaN	5.88E-02	ACSL3,	
Cleavage and Polyadenylation of Pre-mRNA	2.02E-01	NaN	8.33E-02	CSTF3,	
Glutaryl-CoA Degradation	2.02E-01	NaN	8.33E-02	HADHB,	
Purine Nucleotides De Novo Biosynthesis II	2.24E-01	NaN	9.09E-02	ATIC,	
Tumoricidal Function of Hepatic Natural Killer Cells	2.39E-01	NaN	8.33E-02	CYCS,FAS	
Nicotine Degradation II	2.48E-01	NaN	7.94E-02	POR,CYP3A5,CYP4B1,FMO1,AOX1	
Histidine Degradation VI	2.5E-01	NaN	1.00E-01	CYP4F11,	
Stearate Biosynthesis I (Animals)	2.59E-01	NaN	8.33E-02	ACSL3,PPT1,ACOT4	
Cell Cycle: G2/M DNA Damage Checkpoint Regulation	2.59E-01	NaN	8.16E-02	TP53,YWHAG,YWHAH,TOP2A	
Neuropathic Pain Signaling In Dorsal Horn Neurons	2.66E-01	0.7071067811865475	8.00E-02	PIK3R3,PRKACB,FOS,PLCB2,CAMK2D,PLCE1,PIK3R1,PIK3CG	
Nitric Oxide Signaling in the Cardiovascular System	2.66E-01	1.889822365046136	8.00E-02	PIK3R3,PRKACB,CALM1 (includes others),PIK3R1,PIK3CG,SLC7A1,PDGFC,PDE1C	
TGF-β Signaling	2.68E-01	0.3779644730092272	8.05E-02	FOS,TGFBR1,JUN,TGFB2,HRAS,MAPK9,ACVR1C	
Cell Cycle Regulation by BTG Family Proteins	2.74E-01	NaN	8.57E-02	PTPA,BTG2,PPP2R1B	
IL-17A Signaling in Fibroblasts	2.74E-01	NaN	8.57E-02	FOS,JUN,IL17RA	
Triacylglycerol Biosynthesis	2.74E-01	NaN	8.57E-02	DGAT2,AGPAT1,PLPP1	
Ketolysis	2.8E-01	NaN	1.11E-01	HADHB,	
Leucine Degradation I	2.8E-01	NaN	1.11E-01	BCAT1,	
Sucrose Degradation V (Mammalian)	2.8E-01	NaN	1.11E-01	ALDOA,	
UDP-N-acetyl-D-galactosamine Biosynthesis II	2.8E-01	NaN	1.11E-01	HK1,	
Corticotropin Releasing Hormone Signaling	2.83E-01	0.0	8.11E-02	PRKACB,FOS,CALM1 (includes others),ADCY2,JUN,ADCY1,ARPC5,NR4A1,ATF4	
TWEAK Signaling	2.91E-01	NaN	8.82E-02	TRAF3,CYCS,TNFRSF12A	
Basal Cell Carcinoma Signaling	2.92E-01	2.23606797749979	8.33E-02	TP53,KIF7,GLIS2,DVL1,DVL3,WNT5B	
Maturity Onset Diabetes of Young (MODY) Signaling	2.97E-01	NaN	9.52E-02	GAPDH,INSR	
GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells	2.99E-01	NaN	8.33E-02	PRKACB,ADCY2,PLCB2,PLCE1,ADCY1,GNG2,GNG5	
Gαs Signaling	3.02E-01	1.0	8.26E-02	GNB1,PRKACB,ADCY2,ADCY1,GNG2,LHCGR,ATF4,GNG5,HCAR2	
Adipogenesis pathway	3.04E-01	NaN	8.21E-02	TP53,CTBP1,PLIN1,LEP,DDIT3,FGF2,FGFR2,SOX9,HIF1A,TCF7,FGF1	
GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell	3.04E-01	NaN	8.45E-02	PRKACB,GIPR,ADCY2,PLCB2,PLCE1,ADCY1	
Small Cell Lung Cancer Signaling	3.04E-01	NaN	8.45E-02	TP53,PIK3R3,TRAF3,PIK3R1,PIK3CG,CYCS	
Glioblastoma Multiforme Signaling	3.09E-01	1.7320508075688774	8.22E-02	TP53,PIK3R3,PLCB2,RHOG,PLCE1,PDGFA,PIK3R1,PIK3CG,RAC1,HRAS,PDGFC,WNT5B	
Glucose and Glucose-1-phosphate Degradation	3.16E-01	NaN	1.25E-01	HK1,	
Histidine Degradation III	3.16E-01	NaN	1.25E-01	MTHFD1L,	
Purine Ribonucleosides Degradation to Ribose-1-phosphate	3.16E-01	NaN	1.25E-01	CECR1,	
Salvage Pathways of Pyrimidine Deoxyribonucleotides	3.16E-01	NaN	1.25E-01	TYMP,	
Sphingomyelin Metabolism	3.16E-01	NaN	1.25E-01	SMPD1,	
Melatonin Signaling	3.16E-01	0.0	8.57E-02	PRKACB,CALM1 (includes others),PLCB2,CAMK2D,PLCE1,RORB	
Purine Nucleotides Degradation II (Aerobic)	3.21E-01	NaN	1.00E-01	CECR1,AOX1	
ErbB2-ErbB3 Signaling	3.23E-01	NaN	8.77E-02	PIK3R3,JUN,PIK3R1,PIK3CG,HRAS	
Growth Hormone Signaling	3.29E-01	0.8164965809277261	8.70E-02	PIK3R3,FOS,SOCS3,PIK3R1,PIK3CG,STAT1	
Role of MAPK Signaling in the Pathogenesis of Influenza	3.29E-01	NaN	8.70E-02	CXCL10,MAPK10,HRAS,MAPK9,RARRES3,PLA2G2A	
G-Protein Coupled Receptor Signaling	3.31E-01	NaN	8.20E-02	PRKACB,PLCB2,ADCY2,NPY1R,PIK3R1,DUSP6,LHCGR,HRAS,PDE1C,PIK3R3,CAMK2D,NPR3,PIK3CG,ADCY1,ATF4,P2RY12,PDE8B,DUSP4,ADORA1,HCAR2,ADRA1A	
Ovarian Cancer Signaling	3.31E-01	NaN	8.40E-02	TP53,PIK3R3,PRKACB,EDN1,PIK3R1,PIK3CG,DVL1,LHCGR,HRAS,PDGFC,WNT5B	
HGF Signaling	3.43E-01	1.0	8.57E-02	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,RAC1,MAPK10,HRAS,MAPK9	
4-1BB Signaling in T Lymphocytes	3.47E-01	NaN	9.68E-02	JUN,MAPK10,MAPK9	
Salvage Pathways of Pyrimidine Ribonucleotides	3.51E-01	NaN	8.70E-02	NME1,AK1,CSNK1A1,NME2,UCK1,MAPK9,PKN1,IRAK1	
Cellular Effects of Sildenafil (Viagra)	3.51E-01	NaN	8.53E-02	MYL9,PRKACB,CALM1 (includes others),ADCY2,PLCB2,PLCE1,ADCY1,ACTG1,MYL12B,MYL12A,PDE1C	
Adenine and Adenosine Salvage III	3.58E-01	NaN	1.43E-01	CECR1,	
GDP-glucose Biosynthesis	3.58E-01	NaN	1.43E-01	HK1,	
Glycoaminoglycan-protein Linkage Region Biosynthesis	3.58E-01	NaN	1.43E-01	XYLT1,	
Inositol Pyrophosphates Biosynthesis	3.58E-01	NaN	1.43E-01	IP6K3,	
NAD Biosynthesis from 2-amino-3-carboxymuconate Semialdehyde	3.58E-01	NaN	1.43E-01	NMNAT2,	
NAD Salvage Pathway III	3.58E-01	NaN	1.43E-01	NMNAT2,	
Pregnenolone Biosynthesis	3.58E-01	NaN	1.43E-01	CYP4F11,	
Valine Degradation I	3.74E-01	NaN	1.11E-01	BCAT1,HADHB	
Semaphorin Signaling in Neurons	3.86E-01	NaN	9.43E-02	PLXNA1,RHOG,CFL1,CFL2,RAC1	
Apoptosis Signaling	3.88E-01	1.889822365046136	8.99E-02	TP53,CAPN6,CAPNS1,HRAS,CYCS,CAPN2,MAP4K4,FAS	
Cholecystokinin/Gastrin-mediated Signaling	3.9E-01	1.6666666666666667	8.91E-02	FOS,PLCB2,RHOG,JUN,IL1RN,GNA12,MAPK10,HRAS,MAPK9	
IL-17A Signaling in Airway Cells	4.01E-01	0.8164965809277261	9.38E-02	PIK3R3,PIK3R1,PIK3CG,MAPK10,MAPK9,IL17RA	
RANK Signaling in Osteoclasts	4.01E-01	0.7071067811865475	9.09E-02	PIK3R3,FOS,CALM1 (includes others),JUN,PIK3R1,PIK3CG,MAPK10,MAPK9	
CD27 Signaling in Lymphocytes	4.03E-01	0.0	9.62E-02	FOS,JUN,MAPK10,MAPK9,CYCS	
CNTF Signaling	4.03E-01	1.3416407864998738	9.62E-02	PIK3R3,PIK3R1,PIK3CG,HRAS,STAT1	
Heparan Sulfate Biosynthesis (Late Stages)	4.03E-01	NaN	9.62E-02	CHST2,HS6ST1,HS2ST1,CHST11,CHST15	
Adenosine Nucleotides Degradation II	4.04E-01	NaN	1.18E-01	CECR1,AOX1	
Dermatan Sulfate Degradation (Metazoa)	4.04E-01	NaN	1.18E-01	GM2A,HEXA	
Role of PKR in Interferon Induction and Antiviral Response	4.07E-01	NaN	1.00E-01	TP53,TRAF3,CYCS,STAT1	
Arginine Biosynthesis IV	4.08E-01	NaN	1.67E-01	ASS1,	
NAD Biosynthesis III	4.08E-01	NaN	1.67E-01	NMNAT2,	
Pyruvate Fermentation to Lactate	4.08E-01	NaN	1.67E-01	LDHB,	
Rapoport-Luebering Glycolytic Shunt	4.08E-01	NaN	1.67E-01	PGAM1,	
UDP-N-acetyl-D-glucosamine Biosynthesis II	4.08E-01	NaN	1.67E-01	GFPT1,	
Urea Cycle	4.08E-01	NaN	1.67E-01	ASS1,	
Zymosterol Biosynthesis	4.08E-01	NaN	1.67E-01	MSMO1,	
NF-κB Signaling	4.11E-01	2.840187787218772	8.72E-02	PRKACB,TRAF3,TGFBR1,PIK3R1,TLR8,HRAS,FGFR2,IRAK1,PIK3R3,NTRK3,IL1RN,PIK3CG,FCER1G,INSR,MAP4K4	
Regulation of the Epithelial-Mesenchymal Transition Pathway	4.13E-01	NaN	8.70E-02	ADAM17,TGFBR1,FGF2,PIK3R1,EGR1,DVL1,HRAS,NCSTN,FGFR2,HIF1A,FGF1,PIK3R3,PIK3CG,TGFB2,DVL3,WNT5B	
Telomerase Signaling	4.15E-01	0.0	9.09E-02	TP53,PIK3R3,IL2RG,PTPA,PIK3R1,PIK3CG,HRAS,TPP1,PPP2R1B	
ERK5 Signaling	4.18E-01	1.0	9.52E-02	FOS,YWHAG,YWHAH,GNA12,HRAS,ATF4	
IL-15 Signaling	4.18E-01	NaN	9.52E-02	PIK3R3,VCAM1,IL2RG,PIK3R1,PIK3CG,HRAS	
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis	4.27E-01	NaN	8.68E-02	SFRP4,ADAM17,SPP1,PIK3R1,DVL1,CSNK1A1,MAPK9,CSF1R,PIK3R3,FOS,CALM1 (includes others),JUN,IL1RN,PIK3CG,MAPK10,SFRP1,ADAMTS5,ALPL,WNT5B	
Netrin Signaling	4.28E-01	NaN	1.03E-01	PRKACB,UNC5B,RAC1,ENAH	
Glioma Signaling	4.28E-01	1.6666666666666667	9.18E-02	TP53,PIK3R3,CALM1 (includes others),CAMK2D,PDGFA,PIK3R1,PIK3CG,HRAS,PDGFC	
Human Embryonic Stem Cell Pluripotency	4.29E-01	NaN	8.96E-02	PIK3R3,TGFBR1,NTRK3,FGF2,PDGFA,PIK3R1,PIK3CG,DVL1,TGFB2,FGFR2,PDGFC,WNT5B	
ErbB Signaling	4.29E-01	NaN	9.30E-02	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,MAPK10,HRAS,MAPK9	
FLT3 Signaling in Hematopoietic Progenitor Cells	4.31E-01	1.889822365046136	9.46E-02	PIK3R3,GAB2,PIK3R1,PIK3CG,HRAS,ATF4,STAT1	
Molecular Mechanisms of Cancer	4.33E-01	NaN	8.49E-02	PRKACB,RAP2A,GAB2,PLCB2,TGFBR1,PIK3R1,CTNNA1,HRAS,NCSTN,HIF1A,FAS,CAMK2D,JUN,RHOG,CCND3,PIK3CG,TGFB2,ARHGEF2,WNT5B,TP53,ADCY2,GNA12,DVL1,RAC1,MAPK9,PIK3R3,FOS,CCND2,ADCY1,MAPK10,CYCS	
Activation of IRF by Cytosolic Pattern Recognition Receptors	4.34E-01	0.8164965809277261	9.68E-02	TRAF3,JUN,MAPK10,MAPK9,STAT1,ISG15	
GM-CSF Signaling	4.34E-01	1.6329931618554523	9.68E-02	PIK3R3,CAMK2D,PIK3R1,PIK3CG,HRAS,STAT1	
Chondroitin Sulfate Degradation (Metazoa)	4.37E-01	NaN	1.25E-01	GM2A,HEXA	
Assembly of RNA Polymerase II Complex	4.4E-01	NaN	1.00E-01	POLR2I,POLR2G,TAF6,POLR2K,TAF10	
Acetone Degradation I (to Methylglyoxal)	4.41E-01	NaN	1.11E-01	POR,CYP3A5,CYP4B1	
Acute Phase Response Signaling	4.41E-01	1.7320508075688774	8.88E-02	SOCS3,PIK3R1,HRAS,MAPK9,SAA2,HNRNPK,IRAK1,PIK3R3,FOS,HMOX1,FTL,JUN,IL1RN,PIK3CG,SAA1	
NF-κB Activation by Viruses	4.47E-01	NaN	9.59E-02	PIK3R3,ITGB2,PIK3R1,PIK3CG,CD4,ITGAV,HRAS	
Estrogen Biosynthesis	4.5E-01	NaN	1.05E-01	POR,AKR1C3,CYP3A5,CYP4B1	
Noradrenaline and Adrenaline Degradation	4.5E-01	NaN	1.05E-01	ALDH2,ALDH4A1,COMT,ALDH3A2	
Notch Signaling	4.5E-01	0.0	1.05E-01	ADAM17,NCSTN,LFNG,RFNG	
Synaptic Long Term Potentiation	4.65E-01	0.9045340337332909	9.24E-02	PRKACB,CALM1 (includes others),PLCB2,CAMK2D,PLCE1,ADCY1,HRAS,ATF4,PPP1R11,PPP1CA,PPP1R14B	
ErbB4 Signaling	4.7E-01	1.3416407864998738	1.00E-01	PIK3R3,ADAM17,PIK3R1,PIK3CG,HRAS,NCSTN	
Ceramide Biosynthesis	4.71E-01	NaN	2.00E-01	SPTLC3,	
Citrulline-Nitric Oxide Cycle	4.71E-01	NaN	2.00E-01	ASS1,	
Creatine-phosphate Biosynthesis	4.71E-01	NaN	2.00E-01	MAP4K4,	
Eumelanin Biosynthesis	4.71E-01	NaN	2.00E-01	MIF,	
Glutamate Degradation III (via 4-aminobutyrate)	4.71E-01	NaN	2.00E-01	ALDH5A1,	
Lactose Degradation III	4.71E-01	NaN	2.00E-01	GLB1,	
Lysine Degradation V	4.71E-01	NaN	2.00E-01	AASDHPPT,	
Serine Biosynthesis	4.71E-01	NaN	2.00E-01	PSAT1,	
Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate	4.71E-01	NaN	2.00E-01	MTHFD1L,	
dTMP De Novo Biosynthesis	4.71E-01	NaN	2.00E-01	SHMT2,	
Vitamin-C Transport	4.74E-01	NaN	1.33E-01	TXN,TXNRD1	
PTEN Signaling	4.78E-01	-2.1213203435596424	9.32E-02	PIK3R3,TGFBR1,YWHAH,NTRK3,PIK3R1,PIK3CG,RAC1,HRAS,FGFR2,INSR,MCRS1	
Chondroitin Sulfate Biosynthesis (Late Stages)	4.8E-01	NaN	1.04E-01	CHST2,HS6ST1,HS2ST1,CHST11,CHST15	
Dermatan Sulfate Biosynthesis	4.89E-01	NaN	1.02E-01	CHST2,HS6ST1,XYLT1,HS2ST1,CHST11,CHST15	
Heparan Sulfate Biosynthesis	4.89E-01	NaN	1.02E-01	CHST2,HS6ST1,XYLT1,HS2ST1,CHST11,CHST15	
Prostate Cancer Signaling	4.9E-01	NaN	9.76E-02	TP53,PIK3R3,SRD5A1,PIK3R1,PIK3CG,HRAS,ATF4,GSTP1	
Bupropion Degradation	4.98E-01	NaN	1.20E-01	POR,CYP3A5,CYP4B1	
Chronic Myeloid Leukemia Signaling	5E-01	NaN	9.68E-02	TP53,PIK3R3,CTBP1,GAB2,TGFBR1,PIK3R1,PIK3CG,TGFB2,HRAS	
Hematopoiesis from Pluripotent Stem Cells	5.02E-01	NaN	1.06E-01	IGHG3,CD4,IGLC1,FCER1G,IGHA1	
nNOS Signaling in Neurons	5.02E-01	NaN	1.06E-01	CALM1 (includes others),CAPN6,CAPNS1,CAPN2,RASD1	
Estrogen Receptor Signaling	5.02E-01	NaN	9.38E-02	POLR2I,CTBP1,POLR2G,SRA1,TAF6,PCK2,PHB2,HRAS,POLR2K,TAF10,ESR2,CARM1	
Phospholipases	5.08E-01	NaN	1.03E-01	HMOX1,PLCB2,PLCE1,PLD3,RARRES3,PLA2G2A	
Androgen Biosynthesis	5.15E-01	NaN	1.43E-01	AKR1C3,SRD5A1	
Isoleucine Degradation I	5.15E-01	NaN	1.43E-01	BCAT1,HADHB	
γ-glutamyl Cycle	5.15E-01	NaN	1.43E-01	GCLM,GSS	
VEGF Signaling	5.16E-01	2.1213203435596424	9.78E-02	PIK3R3,PIK3R1,PIK3CG,HRAS,HIF1A,PDGFC,ACTG1,EIF2S2,ACTN1	
Ethanol Degradation II	5.23E-01	NaN	1.14E-01	ALDH2,ALDH4A1,ACSS3,ALDH3A2	
Nucleotide Excision Repair Pathway	5.23E-01	NaN	1.14E-01	POLR2I,RPA4,POLR2G,POLR2K	
Dermatan Sulfate Biosynthesis (Late Stages)	5.24E-01	NaN	1.09E-01	CHST2,HS6ST1,HS2ST1,CHST11,CHST15	
MSP-RON Signaling Pathway	5.24E-01	NaN	1.09E-01	PIK3R3,ITGB2,PIK3R1,PIK3CG,ACTG1	
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency	5.24E-01	NaN	1.09E-01	TP53,SPP1,NR5A2,SH3GLB1,NR2F6	
Regulation of Cellular Mechanics by Calpain Protease	5.29E-01	2.0	1.05E-01	CAPN6,CAPNS1,TLN2,HRAS,CAPN2,ACTN1	
FXR/RXR Activation	5.29E-01	NaN	9.52E-02	APOE,SLC4A2,APOB,PCK2,IL1RN,SAA1,APOC1,MAPK10,NR5A2,MAPK9,SAA2,PLTP	
Dopamine-DARPP32 Feedback in cAMP Signaling	5.31E-01	0.2773500981126146	9.32E-02	PRKACB,CALM1 (includes others),ADCY2,PLCB2,PLCE1,PTPA,PPP1R1B,ADCY1,CSNK1A1,ATF4,KCNJ3,PPP1R11,PPP1CA,PPP1R14B,PPP2R1B	
Hepatic Cholestasis	5.31E-01	NaN	9.32E-02	PRKACB,ADCY2,SLC4A2,MAPK9,IRAK1,JUN,IL1RN,ABCC1,ADCY1,TGFB2,MAPK10,NR5A2,CD14,INSR,ABCC3	
Chondroitin Sulfate Biosynthesis	5.5E-01	NaN	1.07E-01	CHST2,HS6ST1,XYLT1,HS2ST1,CHST11,CHST15	
Wnt/Ca+ pathway	5.5E-01	1.6329931618554523	1.07E-01	PLCB2,PLCE1,DVL1,ATF4,DVL3,WNT5B	
Acetate Conversion to Acetyl-CoA	5.51E-01	NaN	2.50E-01	ACSS3,	
Arginine Degradation I (Arginase Pathway)	5.51E-01	NaN	2.50E-01	ALDH4A1,	
Glutathione Redox Reactions II	5.51E-01	NaN	2.50E-01	TXNDC12,	
Heme Biosynthesis from Uroporphyrinogen-III I	5.51E-01	NaN	2.50E-01	FECH,	
Heme Degradation	5.51E-01	NaN	2.50E-01	HMOX1,	
L-cysteine Degradation I	5.51E-01	NaN	2.50E-01	GOT1,	
α-tocopherol Degradation	5.51E-01	NaN	2.50E-01	CYP4A11,	
Erythropoietin Signaling	5.54E-01	NaN	1.04E-01	PIK3R3,FOS,SOCS3,JUN,PIK3R1,PIK3CG,HRAS	
GABA Receptor Signaling	5.54E-01	NaN	1.04E-01	ADCY2,UBQLN1,ADCY1,AP1B1,GABARAP,AP2S1,ALDH5A1	
VDR/RXR Activation	5.59E-01	1.0	1.03E-01	CXCL10,SPP1,PDGFA,HOXA10,TGFB2,CD14,CST6,KLF4	
Bile Acid Biosynthesis, Neutral Pathway	5.6E-01	NaN	1.54E-01	AKR1C1/AKR1C2,AKR1C3	
Choline Biosynthesis III	5.6E-01	NaN	1.54E-01	HMOX1,PLD3	
Gαq Signaling	5.6E-01	2.6726124191242437	9.52E-02	GNB1,PIK3R3,CALM1 (includes others),HMOX1,PLCB2,GYS1,RHOG,PLD3,PIK3R1,PIK3CG,GNG2,GNG5,ADRA1A,GYS2	
TCA Cycle II (Eukaryotic)	5.64E-01	NaN	1.30E-01	SDHB,SDHC,MDH2	
Tryptophan Degradation X (Mammalian, via Tryptamine)	5.64E-01	NaN	1.30E-01	ALDH2,ALDH4A1,ALDH3A2	
Androgen Signaling	5.79E-01	NaN	9.91E-02	POLR2I,GNB1,PRKACB,POLR2G,HSPA4,CALM1 (includes others),JUN,GNA12,GNG2,POLR2K,GNG5	
MIF-mediated Glucocorticoid Regulation	5.79E-01	2.0	1.21E-01	MIF,CD14,CD74,PLA2G2A	
Cardiac β-adrenergic Signaling	5.94E-01	-1.2649110640673518	9.77E-02	PRKACB,ADCY2,GNG2,PPP1R11,PPP1R14B,PDE1C,GNB1,PTPA,ADCY1,PDE8B,GNG5,PPP1CA,PPP2R1B	
Lymphotoxin β Receptor Signaling	5.95E-01	1.6329931618554523	1.11E-01	PIK3R3,VCAM1,TRAF3,PIK3R1,PIK3CG,CYCS	
Natural Killer Cell Signaling	5.95E-01	NaN	1.00E-01	PIK3R3,LAIR1,TYROBP,FCGR2A,PIK3R1,PIK3CG,FCER1G,RAC1,HRAS,LCP2,FCGR3A/FCGR3B	
Polyamine Regulation in Colon Cancer	6E-01	NaN	1.36E-01	PSME1,OAZ1,ODC1	
LXR/RXR Activation	6.02E-01	-1.2649110640673518	9.92E-02	SCD,APOE,LYZ,APOB,MSR1,IL1RN,SAA1,APOC1,CD14,S100A8,SAA2,PLTP	
Insulin Receptor Signaling	6.08E-01	1.386750490563073	9.85E-02	PIK3R3,PRKACB,SOCS3,GYS1,PIK3R1,PIK3CG,HRAS,PPP1R11,INSR,PPP1CA,SCNN1B,PPP1R14B,GYS2	
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells	6.1E-01	NaN	1.25E-01	HLA-A,FCER1G,CYCS,FAS	
Acyl-CoA Hydrolysis	6.11E-01	NaN	1.67E-01	PPT1,ACOT4	
Gαi Signaling	6.17E-01	-1.7320508075688774	1.00E-01	GNB1,PRKACB,ADCY2,NPR3,NPY1R,ADCY1,GNG2,HRAS,P2RY12,GNG5,ADORA1,HCAR2	
HIPPO signaling	6.2E-01	-2.4494897427831783	1.05E-01	YWHAG,YWHAH,AJUBA,PTPA,PPP1R11,PPP1CA,PPP1R14B,AMOT,PPP2R1B	
Melanoma Signaling	6.25E-01	NaN	1.19E-01	TP53,PIK3R3,PIK3R1,PIK3CG,HRAS	
Toll-like Receptor Signaling	6.37E-01	1.3416407864998738	1.08E-01	FOS,JUN,TOLLIP,IL1RN,TLR8,CD14,MAP4K4,IRAK1	
Antiproliferative Role of Somatostatin Receptor 2	6.38E-01	1.889822365046136	1.11E-01	GNB1,PIK3R3,PIK3R1,PIK3CG,GNG2,HRAS,GNG5	
Estrogen-Dependent Breast Cancer Signaling	6.38E-01	NaN	1.11E-01	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,HRAS,ATF4	
Putrescine Degradation III	6.4E-01	NaN	1.43E-01	ALDH2,ALDH4A1,ALDH3A2	
Endometrial Cancer Signaling	6.43E-01	NaN	1.15E-01	TP53,PIK3R3,PIK3R1,PIK3CG,CTNNA1,HRAS	
NGF Signaling	6.45E-01	2.7136021011998728	1.03E-01	TP53,PIK3R3,RHOG,PIK3R1,PIK3CG,RAC1,MAPK10,HRAS,ATF4,MAPK9,SMPD1	
GNRH Signaling	6.54E-01	1.386750490563073	1.01E-01	PRKACB,PLCB2,ADCY2,EGR1,RAC1,MAPK9,HRAS,FOS,CAMK2D,JUN,ADCY1,MAPK10,ATF4	
Allograft Rejection Signaling	6.58E-01	NaN	1.07E-01	HLA-G,CD28,IGHG3,HLA-A,HLA-DRA,FCER1G,HLA-DQA1,HLA-DQB1,FAS	
Melanocyte Development and Pigmentation Signaling	6.58E-01	1.6666666666666667	1.07E-01	PIK3R3,PRKACB,ADCY2,PIK3R1,PIK3CG,ADCY1,KIT,HRAS,ATF4	
1,25-dihydroxyvitamin D3 Biosynthesis	6.59E-01	NaN	3.33E-01	POR,	
4-aminobutyrate Degradation I	6.59E-01	NaN	3.33E-01	ALDH5A1,	
Aspartate Biosynthesis	6.59E-01	NaN	3.33E-01	GOT1,	
Biotin-carboxyl Carrier Protein Assembly	6.59E-01	NaN	3.33E-01	HLCS,	
Coenzyme A Biosynthesis	6.59E-01	NaN	3.33E-01	COASY,	
Glutamate Degradation II	6.59E-01	NaN	3.33E-01	GOT1,	
Hypusine Biosynthesis	6.59E-01	NaN	3.33E-01	EIF5A,	
Inosine-5'-phosphate Biosynthesis II	6.59E-01	NaN	3.33E-01	ATIC,	
Methionine Salvage II (Mammalian)	6.59E-01	NaN	3.33E-01	BHMT2,	
S-adenosyl-L-methionine Biosynthesis	6.59E-01	NaN	3.33E-01	MAT2A,	
Trehalose Degradation II (Trehalase)	6.59E-01	NaN	3.33E-01	HK1,	
Role of JAK1 and JAK3 in γc Cytokine Signaling	6.61E-01	NaN	1.13E-01	PIK3R3,SOCS3,IL2RG,PIK3R1,PIK3CG,HRAS,STAT1	
Glycogen Degradation II	6.68E-01	NaN	1.82E-01	TYMP,PYGB	
Pyrimidine Ribonucleotides De Novo Biosynthesis	6.76E-01	NaN	1.33E-01	NME1,AK1,NME2,CTPS1	
JAK/Stat Signaling	6.8E-01	0.7071067811865475	1.11E-01	PIK3R3,FOS,SOCS3,JUN,PIK3R1,PIK3CG,HRAS,STAT1	
Type II Diabetes Mellitus Signaling	6.83E-01	0.8164965809277261	1.03E-01	PIK3R3,SOCS3,ACSL3,PIK3R1,PIK3CG,PKM,MAPK10,ADIPOQ,MAPK9,SMPD1,INSR,NSMAF	
B Cell Activating Factor Signaling	6.83E-01	1.0	1.25E-01	FOS,TRAF3,JUN,MAPK10,MAPK9	
Neuroprotective Role of THOP1 in Alzheimer's Disease	6.83E-01	NaN	1.25E-01	HLA-G,PRKACB,HLA-A,MAPT,APP	
Thyroid Cancer Signaling	6.83E-01	NaN	1.25E-01	TP53,CXCL10,NTRK3,HRAS,RET	
PPAR Signaling	6.98E-01	-1.2649110640673518	1.08E-01	FOS,SRA1,JUN,IL1RN,PDGFA,HRAS,INSR,PDGFC,MAP4K4,AIP	
Chemokine Signaling	7.02E-01	0.7071067811865475	1.13E-01	FOS,CALM1 (includes others),PLCB2,CAMK2D,JUN,CFL1,PIK3CG,HRAS	
PEDF Signaling	7.02E-01	2.1213203435596424	1.13E-01	TP53,PIK3R3,PIK3R1,PIK3CG,RAC1,HRAS,TCF7,FAS	
Induction of Apoptosis by HIV1	7.1E-01	2.6457513110645903	1.17E-01	TP53,SLC25A6,MAPK10,MAPK9,CYCS,SLC25A5,FAS	
Docosahexaenoic Acid (DHA) Signaling	7.14E-01	NaN	1.28E-01	PIK3R3,PIK3R1,PIK3CG,CYCS,APP	
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses	7.2E-01	2.3333333333333335	1.04E-01	PTX3,PIK3R1,TLR8,MAPK9,C1QC,C1QA,C1QB,PIK3R3,PIK3CG,TGFB2,MAPK10,C3AR1,NLRC4	
Calcium Transport I	7.33E-01	NaN	2.00E-01	ATP2B1,ANXA5	
Embryonic Stem Cell Differentiation into Cardiac Lineages	7.33E-01	NaN	2.00E-01	HOXB5,MESP1	
Glycine Betaine Degradation	7.33E-01	NaN	2.00E-01	BHMT2,SHMT2	
Ketogenesis	7.33E-01	NaN	2.00E-01	HADHB,HMGCS1	
Wnt/β-catenin Signaling	7.35E-01	0.5345224838248488	1.01E-01	TP53,SFRP4,TGFBR1,DVL1,CSNK1A1,JUN,SOX6,PTPA,TGFB2,NR5A2,DVL3,SOX9,SFRP1,SOX18,PPP2R1B,ACVR1C,WNT5B	
ATM Signaling	7.35E-01	0.4472135954999579	1.19E-01	TP53,GADD45B,JUN,TRIM28,MAPK10,ATF4,MAPK9	
Relaxin Signaling	7.4E-01	0.9045340337332909	1.04E-01	GNB1,PIK3R3,PRKACB,FOS,ADCY2,JUN,PIK3R1,GNA12,PIK3CG,ADCY1,GNG2,PDE8B,GNG5,PDE1C	
April Mediated Signaling	7.47E-01	0.4472135954999579	1.32E-01	FOS,TRAF3,JUN,MAPK10,MAPK9	
Agrin Interactions at Neuromuscular Junction	7.49E-01	1.889822365046136	1.16E-01	ITGB2,JUN,DVL1,RAC1,MAPK10,HRAS,MAPK9,ACTG1	
Dopamine Degradation	7.51E-01	NaN	1.43E-01	ALDH2,ALDH4A1,COMT,ALDH3A2	
Pyrimidine Ribonucleotides Interconversion	7.51E-01	NaN	1.43E-01	NME1,AK1,NME2,CTPS1	
Ephrin A Signaling	7.52E-01	NaN	1.25E-01	PIK3R3,CFL1,CFL2,PIK3R1,PIK3CG,RAC1	
Thrombin Signaling	7.58E-01	2.0	1.00E-01	PLCB2,ADCY2,F2RL3,GNA12,PIK3R1,GNG2,HRAS,PIK3R3,MYL9,GNB1,CAMK2D,PLCE1,RHOG,PIK3CG,ADCY1,ARHGEF2,GNG5,MYL12B,MYL12A	
Tight Junction Signaling	7.65E-01	NaN	1.02E-01	PRKACB,TGFBR1,VAPA,RAC1,CTNNA1,GPAA1,MYL9,FOS,JUN,CLDN1,PTPA,TGFB2,ARHGEF2,ACTG1,PPP2R1B,NAPA,CSTF3	
Glioma Invasiveness Signaling	7.89E-01	1.1338934190276817	1.23E-01	PIK3R3,RHOG,TIMP1,PIK3R1,PIK3CG,ITGAV,HRAS	
Gustation Pathway	7.92E-01	NaN	1.07E-01	GNB1,PRKACB,ADCY2,PLCB2,ADCY1,GNG2,P2RY12,PDE8B,GNG5,SCNN1B,PANX1,P2RX7,PDE1C	
Antioxidant Action of Vitamin C	7.97E-01	-2.1213203435596424	1.11E-01	SLC2A5,HMOX1,PLCB2,PLCE1,PLD3,MAPK10,MAPK9,RARRES3,TXN,PLA2G2A,TXNRD1	
Neurotrophin/TRK Signaling	7.99E-01	0.3779644730092272	1.19E-01	PIK3R3,FOS,JUN,NTRK3,PIK3R1,PIK3CG,HRAS,ATF4	
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	8.02E-01	NaN	1.14E-01	CD28,TRAF3,SPP1,IL1RN,HLA-DRA,FCER1G,HLA-DQA1,TLR8,HLA-DQB1,FAS	
G Beta Gamma Signaling	8.02E-01	1.8973665961010275	1.14E-01	GNB1,PRKACB,ADCY2,GNA12,PIK3CG,ADCY1,GNG2,HRAS,KCNJ3,GNG5	
Folate Transformations I	8.07E-01	NaN	2.22E-01	MTHFD1L,SHMT2	
eNOS Signaling	8.1E-01	-0.5345224838248488	1.06E-01	PRKACB,ADCY2,PIK3R1,HSPA9,SLC7A1,HSPA5,PDGFC,HSPA2,HSPA8,PIK3R3,CALM1 (includes others),HSPA4,PIK3CG,ADCY1,ESR2	
HMGB1 Signaling	8.11E-01	1.9414506867883021	1.08E-01	VCAM1,AGER,PIK3R1,RAC1,MAPK9,HRAS,PIK3R3,FOS,JUN,RHOG,PIK3CG,TGFB2,MAPK10	
PDGF Signaling	8.11E-01	1.0	1.17E-01	PIK3R3,FOS,JUN,PDGFA,PIK3R1,PIK3CG,HRAS,STAT1,PDGFC	
autophagy	8.17E-01	NaN	1.39E-01	LAMP2,ATG9A,LAMP1,SQSTM1,VPS11	
EGF Signaling	8.17E-01	0.3779644730092272	1.25E-01	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,HRAS,STAT1	
4-hydroxyproline Degradation I	8.18E-01	NaN	5.00E-01	ALDH4A1,	
Adenine and Adenosine Salvage I	8.18E-01	NaN	5.00E-01	APRT,	
Glycine Biosynthesis I	8.18E-01	NaN	5.00E-01	SHMT2,	
L-DOPA Degradation	8.18E-01	NaN	5.00E-01	COMT,	
L-cysteine Degradation III	8.18E-01	NaN	5.00E-01	GOT1,	
Proline Degradation	8.18E-01	NaN	5.00E-01	ALDH4A1,	
Putrescine Biosynthesis III	8.18E-01	NaN	5.00E-01	ODC1,	
Spermidine Biosynthesis I	8.18E-01	NaN	5.00E-01	SRM,	
UDP-D-xylose and UDP-D-glucuronate Biosynthesis	8.18E-01	NaN	5.00E-01	UXS1,	
Histamine Degradation	8.33E-01	NaN	1.76E-01	ALDH2,ALDH4A1,ALDH3A2	
Fc Epsilon RI Signaling	8.34E-01	2.886751345948129	1.11E-01	PIK3R3,PIK3R1,PIK3CG,FCER1G,FCER1A,RAC1,MAPK10,MS4A2,HRAS,MAPK9,PLA2G2A,LCP2	
D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis	8.35E-01	NaN	1.54E-01	PLCB2,PLCE1,PIP5K1C,PI4KA	
Lipid Antigen Presentation by CD1	8.35E-01	NaN	1.54E-01	FCER1G,PSAP,AP1B1,AP2S1	
Hereditary Breast Cancer Signaling	8.47E-01	NaN	1.09E-01	TP53,POLR2I,GADD45B,PIK3R1,TUBG1,BARD1,HRAS,POLR2K,POLR2G,PIK3R3,FANCE,PIK3CG,SLC19A1,HLTF	
IL-4 Signaling	8.61E-01	NaN	1.20E-01	PIK3R3,IL2RG,PIK3R1,PIK3CG,HLA-DRA,HLA-DQA1,HRAS,HLA-DQB1,HMGA1	
Endothelin-1 Signaling	8.63E-01	1.4142135623730951	1.05E-01	PLCB2,ADCY2,PLD3,GNA12,PIK3R1,HRAS,MAPK9,PLA2G2A,PIK3R3,FOS,HMOX1,JUN,PLCE1,EDN1,PIK3CG,ADCY1,MAPK10,RARRES3	
CCR3 Signaling in Eosinophils	8.7E-01	NaN	1.11E-01	GNB1,PIK3R3,CALM1 (includes others),PLCB2,CFL1,CFL2,PIK3R1,PIK3CG,GNG2,RAC1,HRAS,GNG5,PLA2G2A	
FGF Signaling	8.72E-01	2.5298221281347035	1.18E-01	PIK3R3,FGF2,PIK3R1,PIK3CG,RAC1,HRAS,ATF4,FGFR2,MAPKAPK2,FGF1	
Role of IL-17A in Arthritis	8.77E-01	NaN	1.30E-01	PIK3R3,PIK3R1,PIK3CG,MAPK10,MAPK9,IL17RA,MAPKAPK2	
Calcium-induced T Lymphocyte Apoptosis	8.8E-01	1.0	1.25E-01	CALM1 (includes others),CD4,HLA-DRA,FCER1G,NR4A1,HLA-DQA1,CAPN2,HLA-DQB1	
Role of JAK family kinases in IL-6-type Cytokine Signaling	8.81E-01	NaN	1.60E-01	SOCS3,MAPK10,MAPK9,STAT1	
PI3K Signaling in B Lymphocytes	8.85E-01	-1.6035674514745464	1.10E-01	PLCB2,ATF5,PIK3R1,RAC1,HRAS,PTPRC,CALM1 (includes others),FOS,CAMK2D,JUN,PLCE1,PIK3CG,ATF4,PIK3AP1	
Methylglyoxal Degradation III	8.92E-01	NaN	1.88E-01	AKR1C1/AKR1C2,AKR1C3,AKR1B1	
Parkinson's Signaling	8.92E-01	NaN	1.88E-01	UCHL1,PARK7,CYCS	
Phospholipase C Signaling	8.92E-01	3.771236166328254	1.01E-01	PEBP1,PLCB2,ADCY2,PLD3,FCGR2A,GNG2,RAC1,HRAS,PLA2G2A,GNB1,MYL9,HMOX1,CALM1 (includes others),PLCE1,RHOG,IGHG3,ADCY1,FCER1G,ATF4,ARHGEF2,GNG5,MYL12B,LCP2,MYL12A	
Role of JAK2 in Hormone-like Cytokine Signaling	8.94E-01	NaN	1.47E-01	SOCS3,SH2B3,STAT1,HLTF,SIRPA	
Colorectal Cancer Metastasis Signaling	9.07E-01	2.041241452319315	1.02E-01	TP53,PRKACB,ADCY2,TGFBR1,PIK3R1,GNG2,DVL1,TLR8,RAC1,HRAS,MAPK9,PDGFC,GNB1,PIK3R3,FOS,JUN,RHOG,PIK3CG,ADCY1,TGFB2,MAPK10,GNG5,STAT1,WNT5B	
IL-2 Signaling	9.08E-01	0.8164965809277261	1.32E-01	PIK3R3,FOS,IL2RG,JUN,PIK3R1,PIK3CG,HRAS	
Prolactin Signaling	9.14E-01	1.0	1.23E-01	PIK3R3,FOS,SOCS3,JUN,PIK3R1,PIK3CG,HRAS,TCF7,STAT1	
Role of NFAT in Cardiac Hypertrophy	9.3E-01	2.8284271247461903	1.06E-01	PRKACB,PLCB2,ADCY2,TGFBR1,PIK3R1,GNG2,CSNK1A1,HRAS,MAPK9,PIK3R3,GNB1,CALM1 (includes others),CAMK2D,PLCE1,PIK3CG,ADCY1,TGFB2,MAPK10,GNG5	
RAR Activation	9.3E-01	NaN	1.05E-01	PRKACB,SRA1,ADCY2,AKR1C3,PIK3R1,RAC1,MAPK9,RPL7A,PIK3R3,FOS,JUN,PIK3CG,ADCY1,TGFB2,MAPK10,NR2F6,MAPKAPK2,HLTF,ZBTB16,CARM1	
IL-22 Signaling	9.3E-01	2.0	1.67E-01	SOCS3,MAPK10,MAPK9,STAT1	
B Cell Development	9.35E-01	NaN	1.52E-01	PTPRC,IGLC1,HLA-DRA,HLA-DQA1,HLA-DQB1	
Circadian Rhythm Signaling	9.35E-01	NaN	1.52E-01	PER1,NR1D1,ADCYAP1R1,BHLHE41,ATF4	
PI3K/AKT Signaling	9.67E-01	0.9045340337332909	1.14E-01	TP53,GAB2,RHEB,YWHAG,YWHAH,PIK3R1,GDF15,HRAS,GYS2,PIK3R3,GYS1,PTPA,PIK3CG,PPP2R1B	
IL-3 Signaling	9.69E-01	NaN	1.27E-01	PIK3R3,FOS,GAB2,JUN,PIK3R1,PIK3CG,RAC1,HRAS,STAT1	
T Helper Cell Differentiation	9.69E-01	NaN	1.27E-01	CD28,IL2RG,TGFBR1,HLA-DRA,FCER1G,IL10RA,HLA-DQA1,HLA-DQB1,STAT1	
Gap Junction Signaling	9.7E-01	NaN	1.10E-01	PRKACB,TUBA1B,PLCB2,ADCY2,TUBB4B,PIK3R1,TUBG1,TUBB2A,CSNK1A1,HRAS,TUBB,PIK3R3,PLCE1,PIK3CG,ADCY1,TUBA1C,ACTG1	
FcγRIIB Signaling in B Lymphocytes	9.91E-01	1.6329931618554523	1.46E-01	PIK3R3,PIK3R1,PIK3CG,MAPK10,HRAS,MAPK9	
Aspartate Degradation II	9.96E-01	NaN	2.86E-01	GOT1,MDH2	
Superpathway of Serine and Glycine Biosynthesis I	9.96E-01	NaN	2.86E-01	PSAT1,SHMT2	
Role of Tissue Factor in Cancer	1.02E00	NaN	1.18E-01	TP53,CFL1,GNA12,PIK3R1,EGR1,RAC1,HRAS,PIK3R3,CFL2,PDXP,PIK3CG,ITGAV,CYR61	
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes	1.03E00	NaN	1.27E-01	CD28,FOS,CALM1 (includes others),TGFBR1,JUN,TGFB2,RAC1,MAPK10,HRAS,MAPK9	
Phenylalanine Degradation IV (Mammalian, via Side Chain)	1.03E00	NaN	2.14E-01	ALDH2,ALDH3A2,GOT1	
OX40 Signaling Pathway	1.03E00	0.8164965809277261	1.24E-01	HLA-G,TRAF3,JUN,HLA-A,CD4,HLA-DRA,FCER1G,MAPK10,HLA-DQA1,MAPK9,HLA-DQB1	
Renin-Angiotensin Signaling	1.05E00	1.1547005383792517	1.19E-01	PRKACB,ADCY2,PIK3R1,RAC1,HRAS,MAPK9,PIK3R3,FOS,JUN,PIK3CG,ADCY1,MAPK10,STAT1	
Sphingosine-1-phosphate Signaling	1.05E00	1.9414506867883021	1.19E-01	PIK3R3,ADCY2,PLCB2,RHOG,PLCE1,PDGFA,PIK3R1,GNA12,PIK3CG,ADCY1,RAC1,SMPD1,PDGFC	
p70S6K Signaling	1.06E00	0.5773502691896258	1.18E-01	PLCB2,IL2RG,YWHAG,YWHAH,F2RL3,PIK3R1,HRAS,PIK3R3,PLCE1,PTPA,MAPT,PIK3CG,BCAP31,PPP2R1B	
Dopamine Receptor Signaling	1.06E00	-1.1338934190276817	1.28E-01	PRKACB,ADCY2,PTPA,PPP1R1B,COMT,ADCY1,PPP1R11,PPP1CA,PPP1R14B,PPP2R1B	
CREB Signaling in Neurons	1.07E00	1.7320508075688774	1.11E-01	POLR2I,PRKACB,PLCB2,ADCY2,GNA12,PIK3R1,GNG2,HRAS,POLR2K,POLR2G,PIK3R3,GNB1,CALM1 (includes others),CAMK2D,PLCE1,PIK3CG,ADCY1,ATF4,GNG5	
Primary Immunodeficiency Signaling	1.08E00	NaN	1.46E-01	PTPRC,IL2RG,IGHG3,CD4,IGLC1,IGHA1,UNG	
FAK Signaling	1.09E00	NaN	1.26E-01	PIK3R3,CAPN6,CAPNS1,TLN2,PIK3R1,PIK3CG,RAC1,HRAS,CAPN2,ACTG1,TNS1	
IGF-1 Signaling	1.09E00	0.7071067811865475	1.24E-01	PIK3R3,PRKACB,FOS,IGFBP4,SOCS3,JUN,YWHAG,YWHAH,PIK3R1,PIK3CG,HRAS,CYR61	
Endoplasmic Reticulum Stress Pathway	1.1E00	NaN	1.90E-01	DDIT3,ERN1,ATF4,HSPA5	
Acyl Carrier Protein Metabolism	1.1E00	NaN	1.00E00	AASDHPPT,	
Asparagine Biosynthesis I	1.1E00	NaN	1.00E00	ASNS,	
Glutamine Biosynthesis I	1.1E00	NaN	1.00E00	GLUL,	
Thio-molybdenum Cofactor Biosynthesis	1.1E00	NaN	1.00E00	MOCOS,	
Nur77 Signaling in T Lymphocytes	1.1E00	NaN	1.40E-01	CD28,CALM1 (includes others),HLA-DRA,FCER1G,NR4A1,HLA-DQA1,CYCS,HLA-DQB1	
Gα12/13 Signaling	1.1E00	2.138089935299395	1.20E-01	MYL9,PIK3R3,JUN,F2RL3,CDH18,PIK3R1,GNA12,PIK3CG,CDH20,MAPK10,HRAS,MAPK9,MYL12B,MYL12A	
Glycogen Degradation III	1.11E00	NaN	2.31E-01	GAA,TYMP,PYGB	
Role of IL-17A in Psoriasis	1.11E00	NaN	2.31E-01	S100A7,S100A8,IL17RA	
Pentose Phosphate Pathway (Non-oxidative Branch)	1.12E00	NaN	3.33E-01	RPE,TALDO1	
Selenocysteine Biosynthesis II (Archaea and Eukaryotes)	1.12E00	NaN	3.33E-01	SEPHS2,SARS	
Thioredoxin Pathway	1.12E00	NaN	3.33E-01	TXN,TXNRD1	
Pancreatic Adenocarcinoma Signaling	1.12E00	2.7136021011998728	1.23E-01	TP53,PLD3,TGFBR1,PIK3R1,RAC1,MAPK9,PDGFC,PIK3R3,HMOX1,PIK3CG,MAPK10,TGFB2,STAT1	
PXR/RXR Activation	1.12E00	NaN	1.36E-01	PRKACB,SCD,PCK2,CYP3A5,ALDH3A2,ALAS1,INSR,CES2,ABCC3	
IL-6 Signaling	1.13E00	1.9414506867883021	1.21E-01	SOCS3,PIK3R1,HRAS,MAPK9,PIK3R3,FOS,JUN,IL1RN,PIK3CG,MAPK10,CD14,MAPKAPK2,MAP4K4,HSPB1	
Actin Nucleation by ARP-WASP Complex	1.14E00	2.82842712474619	1.43E-01	RHOG,ARPC1B,ARPC5L,GNA12,ARPC5,RAC1,HRAS,ARPC4	
Tec Kinase Signaling	1.14E00	2.6726124191242437	1.15E-01	GNA12,PIK3R1,TNFRSF10B,GNG2,FCER1A,MAPK9,FAS,PIK3R3,GNB1,FOS,RHOG,PIK3CG,FCER1G,MS4A2,MAPK10,GNG5,STAT1,ACTG1	
AMPK Signaling	1.15E00	-0.7745966692414834	1.12E-01	PRKACB,PFKFB3,LEP,PFKFB1,PIK3R1,ADIPOQ,PFKL,MLST8,GYS2,PIK3R3,AK1,GYS1,PCK2,PTPA,PIK3CG,ATF4,INSR,PPP2R1B,HLTF,ADRA1A	
CD40 Signaling	1.16E00	1.0	1.38E-01	PIK3R3,FOS,TRAF3,JUN,PIK3R1,PIK3CG,MAPK10,MAPK9,MAPKAPK2	
Antigen Presentation Pathway	1.16E00	NaN	1.62E-01	HLA-G,HLA-A,HLA-DRA,HLA-DQA1,CD74,PSMB6	
Fatty Acid α-oxidation	1.16E00	NaN	2.00E-01	ALDH2,ALDH4A1,ALDH3A2,BCO2	
Thrombopoietin Signaling	1.18E00	0.7071067811865475	1.45E-01	PIK3R3,FOS,GAB2,JUN,PIK3R1,PIK3CG,HRAS,STAT1	
Superpathway of Cholesterol Biosynthesis	1.18E00	NaN	1.79E-01	MVD,PMVK,HADHB,MSMO1,HMGCS1	
Leptin Signaling in Obesity	1.18E00	0.4472135954999579	1.35E-01	PIK3R3,PRKACB,SOCS3,ADCY2,PLCB2,PLCE1,LEP,PIK3R1,PIK3CG,ADCY1	
LPS-stimulated MAPK Signaling	1.21E00	1.2649110640673518	1.37E-01	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,RAC1,MAPK10,HRAS,MAPK9,CD14	
STAT3 Pathway	1.21E00	1.8973665961010275	1.37E-01	SOCS3,TGFBR1,NTRK3,RAC1,MAPK10,HRAS,FGFR2,MAPK9,INSR,NDUFA13	
IL-12 Signaling and Production in Macrophages	1.21E00	NaN	1.20E-01	APOE,APOB,PIK3R1,MAF,RAB7A,MAPK9,PIK3R3,FOS,LYZ,JUN,PIK3CG,APOC1,TGFB2,MAPK10,S100A8,STAT1	
B Cell Receptor Signaling	1.23E00	2.6678918753996625	1.15E-01	GAB2,RAP2A,CFL1,FCGR2A,EGR1,PIK3R1,RAC1,HRAS,MAPK9,PIK3R3,PTPRC,CALM1 (includes others),CAMK2D,IGHG3,JUN,CFL2,PAG1,PIK3CG,ATF4,PIK3AP1	
Cysteine Biosynthesis III (mammalia)	1.23E00	NaN	2.11E-01	AHCYL1,PRMT3,PRMT5,MAT2A	
GADD45 Signaling	1.23E00	NaN	2.11E-01	TP53,GADD45B,CCND2,CCND3	
Oxidative Ethanol Degradation III	1.23E00	NaN	2.11E-01	ALDH2,ALDH4A1,ACSS3,ALDH3A2	
iNOS Signaling	1.25E00	NaN	1.59E-01	FOS,CALM1 (includes others),JUN,CD14,HMGA1,STAT1,IRAK1	
UVB-Induced MAPK Signaling	1.25E00	0.7071067811865475	1.51E-01	TP53,PIK3R3,FOS,JUN,PIK3R1,PIK3CG,MAPK10,MAPK9	
2-oxobutanoate Degradation I	1.27E00	NaN	4.00E-01	PCCA,PCCB	
Folate Polyglutamylation	1.27E00	NaN	4.00E-01	MTHFD1L,SHMT2	
Lysine Degradation II	1.27E00	NaN	4.00E-01	AASDHPPT,AASS	
Renal Cell Carcinoma Signaling	1.28E00	0.3779644730092272	1.41E-01	PIK3R3,FOS,JUN,PIK3R1,PIK3CG,RBX1,RAC1,HRAS,HIF1A,TCEB2	
Type I Diabetes Mellitus Signaling	1.28E00	2.82842712474619	1.27E-01	SOCS3,HLA-A,HLA-DQA1,MAPK9,HLA-DQB1,FAS,IRAK1,HLA-G,CD28,HLA-DRA,MAPK10,FCER1G,CYCS,STAT1	
phagosome formation	1.31E00	NaN	1.28E-01	PLCB2,MSR1,FCGR2A,MRC2,PIK3R1,TLR8,FCER1A,PIK3R3,PLCE1,RHOG,IGHG3,PIK3CG,FCER1G,FCGR3A/FCGR3B	
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis	1.31E00	NaN	1.24E-01	SOCS3,PPP1R1B,PPFIBP2,PPTC7,NUDT14,PPP1R14B,PTPRC,CA3,PTPRJ,PTPA,PDXP,DUSP10,MTMR2,PPP1CA,ALPL,SIRPA	
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis	1.31E00	NaN	1.24E-01	SOCS3,PPP1R1B,PPFIBP2,PPTC7,NUDT14,PPP1R14B,PTPRC,CA3,PTPRJ,PTPA,PDXP,DUSP10,MTMR2,PPP1CA,ALPL,SIRPA	
IL-9 Signaling	1.31E00	1.6329931618554523	1.76E-01	PIK3R3,SOCS3,IL2RG,PIK3R1,PIK3CG,STAT1	
Inhibition of Angiogenesis by TSP1	1.31E00	0.4472135954999579	1.76E-01	TP53,TGFBR1,JUN,THBS1,MAPK10,MAPK9	
Communication between Innate and Adaptive Immune Cells	1.32E00	NaN	1.35E-01	HLA-G,CXCL10,CD28,IGHG3,IL1RN,HLA-A,CD4,HLA-DRA,FCER1G,TLR8,CD83,IGHA1	
PKCθ Signaling in T Lymphocytes	1.34E00	NaN	1.27E-01	CD4,PIK3R1,HLA-DQA1,RAC1,HRAS,HLA-DQB1,PIK3R3,CD28,FOS,CAMK2D,JUN,PIK3CG,HLA-DRA,FCER1G,LCP2	
Amyloid Processing	1.34E00	2.23606797749979	1.57E-01	PRKACB,CAPN6,CAPNS1,MAPT,CSNK1A1,NCSTN,CAPN2,APP	
UVC-Induced MAPK Signaling	1.34E00	1.1338934190276817	1.67E-01	TP53,FOS,JUN,MAPK10,HRAS,MAPK9,SMPD1	
CTLA4 Signaling in Cytotoxic T Lymphocytes	1.35E00	NaN	1.36E-01	PIK3R3,CD28,HLA-A,PTPA,PIK3R1,PIK3CG,CLTB,FCER1G,AP1B1,PPP2R1B,LCP2,AP2S1	
p38 MAPK Signaling	1.36E00	3.05085107923876	1.28E-01	TP53,TGFBR1,DDIT3,MKNK2,FAS,PLA2G2A,IRAK1,IL1RN,DUSP10,MAPT,TGFB2,ATF4,STAT1,MAPKAPK2,HSPB1	
Sertoli Cell-Sertoli Cell Junction Signaling	1.37E00	NaN	1.18E-01	PRKACB,TUBA1B,TUBB4B,TUBG1,TUBB2A,RAC1,CTNNA1,HRAS,MAPK9,TUBB,JUN,SORBS1,CLDN1,KEAP1,MAPK10,SPTB,TUBA1C,MTMR2,ACTG1,RAB8B,ACTN1	
Cdc42 Signaling	1.38E00	2.6726124191242437	1.20E-01	CFL1,ARPC1B,ARPC5L,HLA-A,ARPC5,HLA-DQA1,MAPK9,HLA-DQB1,CLIP1,MYL9,HLA-G,FOS,JUN,CFL2,HLA-DRA,FCER1G,MAPK10,MYL12B,ARPC4,MYL12A	
α-Adrenergic Signaling	1.38E00	1.1338934190276817	1.38E-01	GNB1,PRKACB,CALM1 (includes others),ADCY2,GYS1,ADCY1,GNG2,HRAS,PYGB,GNG5,ADRA1A,GYS2	
IL-10 Signaling	1.39E00	NaN	1.47E-01	CCR1,FOS,SOCS3,HMOX1,JUN,IL1RN,FCGR2A,IL10RA,CD14,MAP4K4	
Macropinocytosis Signaling	1.39E00	1.6329931618554523	1.47E-01	PIK3R3,ITGB2,PDGFA,PIK3R1,PIK3CG,RAC1,HRAS,CD14,PDGFC,CSF1R	
Methionine Degradation I (to Homocysteine)	1.39E00	NaN	2.35E-01	AHCYL1,PRMT3,PRMT5,MAT2A	
Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)	1.39E00	NaN	2.35E-01	MVD,PMVK,HADHB,HMGCS1	
3-phosphoinositide Degradation	1.39E00	NaN	1.23E-01	SOCS3,PPP1R1B,PPFIBP2,MTMR14,PPTC7,NUDT14,PPP1R14B,PTPRC,CA3,PTPRJ,TMEM55A,PTPA,PDXP,DUSP10,MTMR2,PPP1CA,ALPL,SIRPA	
ERK/MAPK Signaling	1.4E00	0.4472135954999579	1.18E-01	PRKACB,YWHAG,YWHAH,PIK3R1,DUSP6,RAC1,HRAS,PPP1R11,MKNK2,PPP1R14B,PLA2G2A,PIK3R3,FOS,TLN2,PTPA,PIK3CG,ATF4,DUSP4,PPP1CA,STAT1,PPP2R1B,HSPB1	
Dolichyl-diphosphooligosaccharide Biosynthesis	1.41E00	NaN	3.00E-01	ALG3,DPM2,DPM3	
G Protein Signaling Mediated by Tubby	1.43E00	NaN	1.88E-01	GNB1,PLCB2,GNG2,TUB,INSR,GNG5	
Glutamate Receptor Signaling	1.47E00	NaN	1.58E-01	GNB1,CALM1 (includes others),SLC1A4,GNG2,SLC1A3,SLC1A2,GLUL,SLC38A1,GNG5	
Methylmalonyl Pathway	1.47E00	NaN	5.00E-01	PCCA,PCCB	
Pentose Phosphate Pathway (Oxidative Branch)	1.47E00	NaN	5.00E-01	PGD,G6PD	
Phenylethylamine Degradation I	1.47E00	NaN	5.00E-01	ALDH2,ALDH3A2	
RAN Signaling	1.48E00	NaN	2.50E-01	TNPO1,RAN,KPNA2,KPNA1	
Systemic Lupus Erythematosus Signaling	1.49E00	NaN	1.17E-01	HLA-A,PIK3R1,TXNL4A,HRAS,HLA-G,PTPRC,CD28,JUN,IGHG3,PIK3CG,SNRPD2,SNU13,LSM10,FCGR3A/FCGR3B,LSM4,SNRPA,FCGR2A,SNRPF,PIK3R3,FOS,SNRPC,IL1RN,SNRNP25,FCER1G,C6	
Ethanol Degradation IV	1.5E00	NaN	2.17E-01	ALDH2,ALDH4A1,ACSS3,ALDH3A2,CYGB	
Cardiac Hypertrophy Signaling	1.52E00	3.4	1.17E-01	PRKACB,PLCB2,TGFBR1,PIK3R1,HRAS,GNB1,RHOG,PLCE1,JUN,PIK3CG,TGFB2,MAPKAPK2,GNG5,MYL12B,MYL12A,ADCY2,GNA12,GNG2,MAPK9,PIK3R3,MYL9,CALM1 (includes others),ADCY1,MAPK10,ADRA1A,HSPB1	
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis	1.53E00	NaN	1.11E-01	SOCS3,TRAF3,PLCB2,PDGFA,FGF2,PIK3R1,CSNK1A1,TLR8,HRAS,IL17RA,PDGFC,CEBPG,IRAK1,CAMK2D,PLCE1,JUN,IGHG3,PIK3CG,ATF4,MAPKAPK2,WNT5B,FCGR3A/FCGR3B,SFRP4,MIF,VCAM1,DVL1,RAC1,MAPK9,PIK3R3,FOS,CALM1 (includes others),IL1RN,SFRP1	
Pathogenesis of Multiple Sclerosis	1.54E00	NaN	3.33E-01	CCR1,CXCL10,CXCL9	
Aryl Hydrocarbon Receptor Signaling	1.55E00	2.0	1.29E-01	TP53,ALDH4A1,NQO1,FAS,AIP,FOS,CTSD,JUN,CCND2,CCND3,ALDH1L2,ALDH3A2,TGFB2,ESR2,NFE2L2,ALDH5A1,GSTP1,HSPB1	
Ephrin B Signaling	1.55E00	0.3779644730092272	1.51E-01	GNB1,CFL1,ITSN1,CFL2,GNA12,GNG2,RAC1,EPHB3,HRAS,GNG5,HNRNPK	
Role of p14/p19ARF in Tumor Suppression	1.55E00	-0.8164965809277261	2.00E-01	TP53,PIK3R3,PIK3R1,PIK3CG,RAC1,SENP3	
IL-1 Signaling	1.57E00	0.6324555320336759	1.43E-01	GNB1,PRKACB,FOS,ADCY2,JUN,TOLLIP,GNA12,ADCY1,GNG2,MAPK10,MAPK9,GNG5,IRAK1	
nNOS Signaling in Skeletal Muscle Cells	1.58E00	NaN	2.67E-01	CALM1 (includes others),SNTB1,SNTA1,DMD	
IL-17 Signaling	1.59E00	NaN	1.53E-01	PIK3R3,CXCL10,JUN,TIMP1,PIK3R1,PIK3CG,MAPK10,HRAS,MAPK9,IL17RA,MAPKAPK2	
P2Y Purigenic Receptor Signaling Pathway	1.59E00	1.0	1.34E-01	PRKACB,PLCB2,ADCY2,PIK3R1,GNG2,HRAS,PIK3R3,GNB1,FOS,JUN,PLCE1,PIK3CG,ADCY1,P2RY12,ATF4,GNG5	
Ceramide Signaling	1.63E00	0.6324555320336759	1.50E-01	PIK3R3,FOS,CTSD,JUN,PTPA,PIK3R1,PIK3CG,HRAS,CYCS,SMPD1,NSMAF,PPP2R1B	
Crosstalk between Dendritic Cells and Natural Killer Cells	1.64E00	NaN	1.46E-01	CD209,IL2RG,HLA-A,TYROBP,CD83,FAS,HLA-G,CD28,TLN2,CAMK2D,TREM2,HLA-DRA,ACTG1	
Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I	1.67E00	NaN	2.38E-01	NME1,AK1,RRM2B,NME2,DTYMK	
D-myo-inositol-5-phosphate Metabolism	1.69E00	NaN	1.31E-01	SOCS3,PLCB2,PPP1R1B,PPFIBP2,PPTC7,NUDT14,PPP1R14B,PTPRC,CA3,PLCE1,PTPRJ,TMEM55A,PTPA,PDXP,DUSP10,MTMR2,PPP1CA,ALPL,SIRPA	
Superoxide Radicals Degradation	1.69E00	NaN	3.75E-01	NQO1,CYGB,SOD1	
T Cell Receptor Signaling	1.69E00	NaN	1.44E-01	CD4,PIK3R1,RAC1,HRAS,PTPRC,PIK3R3,CD28,SHB,CALM1 (includes others),FOS,JUN,PAG1,PIK3CG,LCP2	
Ephrin Receptor Signaling	1.71E00	2.3094010767585034	1.26E-01	CFL1,ITSN1,ARPC1B,ARPC5L,PDGFA,GNA12,GNG2,ARPC5,RAC1,HRAS,PDGFC,FGF1,GNB1,SDCBP,CFL2,SORBS1,PIK3CG,EPHB3,ATF4,GNG5,MAP4K4,ARPC4	
CCR5 Signaling in Macrophages	1.72E00	NaN	1.59E-01	GNB1,FOS,CALM1 (includes others),JUN,CD4,GNG2,FCER1G,MAPK10,MAPK9,GNG5,FAS	
Atherosclerosis Signaling	1.74E00	NaN	1.37E-01	APOE,VCAM1,APOB,MSR1,PDGFA,CMA1,PDGFC,PLA2G2A,TPSAB1/TPSB2,TNFRSF12A,ITGB2,COL5A3,LYZ,IL1RN,APOC1,RARRES3,S100A8	
Glutathione Biosynthesis	1.75E00	NaN	6.67E-01	GCLM,GSS	
Methylglyoxal Degradation I	1.75E00	NaN	6.67E-01	GLO1,HAGH	
NADH Repair	1.75E00	NaN	6.67E-01	NAXE,GAPDH	
Thyroid Hormone Biosynthesis	1.75E00	NaN	6.67E-01	CTSD,TPO	
Granzyme A Signaling	1.75E00	NaN	2.50E-01	HIST1H1B,HIST1H1C,NME1,HIST1H1E,H1F0	
GDNF Family Ligand-Receptor Interactions	1.76E00	NaN	1.62E-01	PIK3R3,DOK5,FOS,JUN,PIK3R1,PIK3CG,RAC1,MAPK10,HRAS,MAPK9,RET	
Xenobiotic Metabolism Signaling	1.78E00	NaN	1.17E-01	ALDH4A1,PIK3R1,HS2ST1,MAF,HRAS,CES2,CHST15,CHST2,HMOX1,HS6ST1,CES1,CAMK2D,CYP3A5,ALDH3A2,PIK3CG,KEAP1,CHST11,FMO1,NFE2L2,ALDH5A1,SRA1,NQO1,MAPK9,AIP,PIK3R3,FTL,ALDH1L2,PTPA,RBX1,ABCC3,PPP2R1B,GSTP1	
LPS/IL-1 Mediated Inhibition of RXR Function	1.79E00	1.2649110640673518	1.22E-01	ALDH4A1,APOE,HS2ST1,CES2,ALAS1,CHST15,IRAK1,CHST2,HS6ST1,JUN,CYP3A5,ALDH3A2,CHST11,FMO1,HMGCS1,ALDH5A1,ACSL3,MAPK9,ALDH1L2,IL1RN,APOC1,NR5A2,CD14,PLTP,ABCC3,CYP4A11,GSTP1	
TR/RXR Activation	1.8E00	NaN	1.53E-01	PIK3R3,ENO1,UCP2,AKR1C1/AKR1C2,GPS2,AKR1C3,SREBF2,PIK3R1,PIK3CG,SYT2,ME1,HIF1A,THRSP	
Mevalonate Pathway I	1.8E00	NaN	3.08E-01	MVD,PMVK,HADHB,HMGCS1	
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	1.81E00	1.0425720702853738	1.28E-01	APOE,APOB,PIK3R1,RAC1,MAPK9,PPP1R11,PPP1R14B,PIK3R3,FOS,LYZ,JUN,RHOG,PTPA,PIK3CG,HOXA10,APOC1,CYBB,MAPK10,S100A8,PPP1CA,STAT1,PPP2R1B,SIRPA	
Paxillin Signaling	1.88E00	2.7136021011998728	1.49E-01	ARF1,PIK3R1,ITGA8,RAC1,HRAS,MAPK9,PIK3R3,ITGB2,TLN2,PIK3CG,ITGAV,MAPK10,ACTG1,ITGA7,ACTN1	
Dendritic Cell Maturation	1.89E00	3.4112114616897666	1.30E-01	PLCB2,LEP,TYROBP,FCGR2A,HLA-A,PIK3R1,HLA-DQA1,MAPK9,CD83,HLA-DQB1,PIK3R3,COL5A3,IGHG3,PLCE1,IL1RN,TREM2,PIK3CG,HLA-DRA,FCER1G,MAPK10,ATF4,STAT1,FCGR3A/FCGR3B	
Regulation of Actin-based Motility by Rho	1.92E00	3.6055512754639896	1.54E-01	PFN1,ARPC1B,CFL1,ARPC5L,ARPC5,RAC1,MYL9,RHOG,PIP5K1C,ARHGDIA,MYL12B,ARPC4,PI4KA,MYL12A	
Graft-versus-Host Disease Signaling	1.92E00	NaN	1.88E-01	HLA-G,CD28,IL1RN,HLA-A,HLA-DRA,FCER1G,HLA-DQA1,HLA-DQB1,FAS	
Glycolysis I	1.93E00	NaN	2.40E-01	ENO1,PGAM1,PKM,GAPDH,ALDOA,PFKL	
IL-17A Signaling in Gastric Cells	1.93E00	NaN	2.40E-01	CXCL10,FOS,JUN,MAPK10,MAPK9,IL17RA	
3-phosphoinositide Biosynthesis	1.93E00	NaN	1.35E-01	SOCS3,PPP1R1B,PIK3R1,PPFIBP2,PPTC7,NUDT14,PPP1R14B,PIK3R3,PTPRC,CA3,PTPRJ,PTPA,PDXP,PIP5K1C,DUSP10,PIK3CG,MTMR2,PPP1CA,ALPL,SIRPA,PI4KA	
Glucocorticoid Receptor Signaling	1.96E00	NaN	1.20E-01	PRKACB,TGFBR1,YWHAH,PIK3R1,HRAS,TAF10,HSPA5,HSPA4,JUN,PCK2,ANXA1,PIK3CG,TGFB2,STAT1,FKBP5,POLR2I,SRA1,VCAM1,TAF6,HSPA9,RAC1,MAPK9,POLR2K,HSPA2,HSPA8,POLR2G,PIK3R3,FOS,IL1RN,FKBP4,MAPK10,HLTF,UBE2I	
CDK5 Signaling	1.96E00	-0.7745966692414834	1.52E-01	PRKACB,ADCY2,PPP1R1B,EGR1,HRAS,MAPK9,PPP1R11,PPP1R14B,FOSB,PTPA,MAPT,ADCY1,MAPK10,PPP1CA,PPP2R1B	
fMLP Signaling in Neutrophils	1.96E00	3.3565855667130946	1.48E-01	FPR3,PLCB2,ARPC1B,ARPC5L,PIK3R1,GNG2,ARPC5,RAC1,HRAS,PIK3R3,GNB1,CALM1 (includes others),PIK3CG,CYBB,GNG5,ARPC4	
iCOS-iCOSL Signaling in T Helper Cells	1.96E00	2.886751345948129	1.48E-01	GAB2,IL2RG,CD4,PIK3R1,HLA-DQA1,RAC1,HLA-DQB1,PIK3R3,PTPRC,CD28,CALM1 (includes others),CAMK2D,PIK3CG,HLA-DRA,FCER1G,LCP2	
Superpathway of Inositol Phosphate Compounds	1.99E00	NaN	1.30E-01	SOCS3,PLCB2,PIK3R1,PPFIBP2,NUDT14,PPP1R14B,PTPRC,CA3,PLCE1,IP6K3,PTPRJ,PIK3CG,DUSP10,MTMR2,PPP1CA,ALPL,PI4KA,PPP1R1B,PPTC7,PIK3R3,TMEM55A,PTPA,PDXP,PIP5K1C,SIRPA	
Amyotrophic Lateral Sclerosis Signaling	2E00	NaN	1.53E-01	TP53,CAPN6,RAB5C,PIK3R1,RAC1,SOD1,PDGFC,PIK3R3,CAPNS1,PIK3CG,GLUL,SLC1A2,CYCS,CAPN2,SSR4	
Virus Entry via Endocytic Pathways	2E00	NaN	1.57E-01	PIK3R3,ITGB2,ITSN1,FLNC,HLA-A,FLNA,PIK3R1,PIK3CG,CLTB,RAC1,HRAS,AP1B1,ACTG1,AP2S1	
Caveolar-mediated Endocytosis Signaling	2.02E00	NaN	1.69E-01	ITGB2,RAB5C,ITSN1,FLNC,HLA-A,FLNA,ITGA8,ITGAV,FLOT1,INSR,ACTG1,ITGA7	
Protein Kinase A Signaling	2.03E00	-0.15617376188860607	1.14E-01	PRKACB,HIST1H1C,PLCB2,TGFBR1,YWHAH,DUSP6,PPP1R14B,GNB1,PTPRC,CAMK2D,PLCE1,GYS1,PTPRJ,FLNA,DUSP10,TGFB2,ATF4,PGP,GNG5,PPP1CA,ANAPC11,EYA2,MYL12B,MYL12A,ADCY2,PTPRK,YWHAG,PPP1R1B,GNG2,PPP1R11,PYGB,GYS2,PDE1C,HIST1H1B,MYL9,CALM1 (includes others),HIST1H1E,FLNC,ADCY1,CDC14B,PDE8B,DUSP4,H1F0,SIRPA	
UVA-Induced MAPK Signaling	2.04E00	2.1105794120443453	1.59E-01	TP53,PLCB2,PIK3R1,MAPK9,HRAS,SMPD1,PIK3R3,FOS,JUN,PLCE1,PIK3CG,MAPK10,CYCS,STAT1	
Reelin Signaling in Neurons	2.05E00	NaN	1.65E-01	PIK3R3,PAFAH1B2,APOE,ITGB2,PIK3R1,PIK3CG,MAPT,MAPK8IP2,MAPK10,MAPK9,ARHGEF2,DCX,APP	
Glycogen Biosynthesis II (from UDP-D-Glucose)	2.08E00	NaN	5.00E-01	GYS1,GBE1,GYS2	
Rac Signaling	2.12E00	2.5	1.54E-01	CFL1,ARPC1B,ARPC5L,PIK3R1,ARPC5,RAC1,HRAS,PIK3R3,MCF2L,JUN,CFL2,PIP5K1C,PIK3CG,CYBB,PI4KA,ARPC4	
Complement System	2.13E00	0.4472135954999579	2.16E-01	ITGB2,C1QA,C1QC,CFH,C1QB,C6,C1QBP,C3AR1	
Integrin Signaling	2.15E00	4.2	1.30E-01	RAP2A,PFN1,ARPC1B,ARF1,PIK3R1,ARPC5,ITGA8,HRAS,RHOG,PIK3CG,ITGAV,MYL12B,ACTN1,MYL12A,CAPN6,ARPC5L,RAC1,GIT1,PIK3R3,MYL9,ITGB2,TLN2,CAPNS1,CAPN2,ITGA7,ACTG1,ARPC4	
HIF1α Signaling	2.2E00	NaN	1.57E-01	TP53,SLC2A5,PIK3R1,MAPK9,HRAS,HIF1A,TCEB2,NAA10,PDGFC,LDHB,PIK3R3,JUN,EDN1,RBX1,PIK3CG,MAPK10	
ILK Signaling	2.22E00	1.8	1.35E-01	PIK3R1,HIF1A,PDGFC,PPP1R14B,RHOG,JUN,CFL2,FLNA,PIK3CG,ATF4,TMSB10/TMSB4X,ACTN1,TESK1,NACA,CFL1,MAPK9,PIK3R3,MYL9,ITGB2,FOS,PTPA,FLNC,MAPK10,PPP2R1B,ACTG1	
Pentose Phosphate Pathway	2.25E00	NaN	4.00E-01	PGD,RPE,TALDO1,G6PD	
Myc Mediated Apoptosis Signaling	2.28E00	NaN	1.90E-01	TP53,PIK3R3,YWHAG,YWHAH,PIK3R1,PIK3CG,MAPK10,HRAS,MAPK9,CYCS,FAS	
Hepatic Fibrosis / Hepatic Stellate Cell Activation	2.28E00	NaN	1.37E-01	IGFBP4,VCAM1,COL5A2,TGFBR1,LEP,FGF2,PDGFA,BAMBI,FGFR2,COL8A1,CXCL9,PDGFC,COL15A1,COL6A6,FAS,FGF1,COL16A1,MYL9,COL5A3,EDN1,TIMP1,TGFB2,IL10RA,CD14,STAT1	
Tetrapyrrole Biosynthesis II	2.36E00	NaN	6.00E-01	UROS,ALAS1,HMBS	
Role of NFAT in Regulation of the Immune Response	2.36E00	2.6678918753996625	1.40E-01	PLCB2,FCGR2A,CD4,GNA12,PIK3R1,GNG2,CSNK1A1,FCER1A,HLA-DQA1,HRAS,HLA-DQB1,GNB1,PIK3R3,CD28,FOS,CALM1 (includes others),JUN,PIK3CG,HLA-DRA,FCER1G,MS4A2,GNG5,LCP2,FCGR3A/FCGR3B	
p53 Signaling	2.37E00	0.2773500981126146	1.63E-01	TP53,GADD45B,PIK3R1,RRM2B,TNFRSF10B,HIF1A,FAS,SERPINE2,SCO2,PIK3R3,JUN,CCND2,THBS1,PIK3CG,ADCK3,GNL3	
MIF Regulation of Innate Immunity	2.38E00	1.0	2.20E-01	TP53,FOS,MIF,JUN,MAPK10,MAPK9,CD14,CD74,PLA2G2A	
Heme Biosynthesis II	2.45E00	NaN	4.44E-01	UROS,FECH,ALAS1,HMBS	
Autoimmune Thyroid Disease Signaling	2.49E00	NaN	2.13E-01	HLA-G,CD28,IGHG3,HLA-A,HLA-DRA,FCER1G,HLA-DQA1,TPO,HLA-DQB1,FAS	
Superpathway of Methionine Degradation	2.54E00	NaN	2.50E-01	PCCA,AHCYL1,PRMT3,PRMT5,PCCB,GOT1,MAT2A,BHMT2	
Gluconeogenesis I	2.58E00	NaN	2.80E-01	ENO1,PGAM1,GAPDH,ALDOA,ME2,ME1,MDH2	
RhoGDI Signaling	2.61E00	-1.5275252316519468	1.45E-01	ARPC1B,CDH18,ARPC5,GNB1,RHOG,CFL2,ARHGEF2,GNG5,PI4KA,MYL12B,MYL12A,CFL1,ARPC5L,GNA12,GNG2,RAC1,ARHGDIB,MYL9,PIP5K1C,CDH20,ARHGAP35,ARHGDIA,ESR2,ACTG1,ARPC4	
Breast Cancer Regulation by Stathmin1	2.63E00	NaN	1.41E-01	PRKACB,TUBA1B,PLCB2,PIK3R1,HRAS,TUBB,PPP1R14B,GNB1,CAMK2D,PIK3CG,TUBA1C,ARHGEF2,PPP1CA,GNG5,TP53,ADCY2,TUBB4B,TUBG1,GNG2,TUBB2A,RAC1,PPP1R11,PIK3R3,CALM1 (includes others),PTPA,ADCY1,PPP2R1B	
14-3-3-mediated Signaling	2.68E00	1.1547005383792517	1.62E-01	TUBA1B,PLCB2,YWHAG,YWHAH,TUBB4B,PIK3R1,TUBG1,TUBB2A,HRAS,MAPK9,TUBB,PIK3R3,FOS,JUN,PLCE1,MAPT,PIK3CG,MAPK10,TUBA1C	
CXCR4 Signaling	2.7E00	2.6832815729997477	1.51E-01	PLCB2,ADCY2,CD4,GNA12,PIK3R1,EGR1,GNG2,RAC1,HRAS,MAPK9,GNB1,MYL9,PIK3R3,FOS,JUN,RHOG,PIK3CG,ADCY1,MAPK10,GNG5,ELMO2,MYL12B,MYL12A	
Axonal Guidance Signaling	2.74E00	NaN	1.20E-01	PRKACB,TUBA1B,PLCB2,PFN1,ITSN1,PIK3R1,ARPC5,UNC5B,HRAS,TUBB,GNB1,PLCE1,CFL2,PIK3CG,PLXNB2,TUBA1C,CHMP1A,ADAMTS5,WNT5B,CFL1,GNG2,TUBB2A,RAC1,PIK3R3,MYL9,SDCBP,ADAM12,RTN4,ERAP2,ADAM17,ARPC1B,PDGFA,PDGFC,SRGAP1,PSMD14,GNG5,MYL12B,MYL12A,PLXNA1,ARPC5L,TUBB4B,GNA12,TUBG1,PLXND1,GIT1,KIF7,GLIS2,NTRK3,EPHB3,SEMA3C,SEMA4B,ARPC4	
PAK Signaling	2.81E00	2.6726124191242437	1.80E-01	CFL1,PDGFA,PIK3R1,RAC1,MAPK9,HRAS,PDGFC,GIT1,PIK3R3,MYL9,CFL2,PIK3CG,MAPK10,EPHB3,MYL12B,MYL12A	
Huntington's Disease Signaling	2.92E00	1.0	1.40E-01	PLCB2,SDHB,PIK3R1,CLTB,HRAS,RCOR2,HSPA5,GNB1,CTSD,HSPA4,JUN,PIK3CG,ATF4,GNG5,NAPA,TP53,POLR2I,ATP5J,CAPN6,HSPA9,GNG2,MAPK9,POLR2K,HSPA2,GPAA1,HSPA8,POLR2G,PIK3R3,PSME1,CAPNS1,CYCS,CAPN2	
Epithelial Adherens Junction Signaling	2.94E00	NaN	1.58E-01	TUBA1B,TGFBR1,ARPC1B,ARPC5L,TUBB4B,TUBG1,TUBB2A,ARPC5,RAC1,CTNNA1,HRAS,TUBB,CLIP1,FGF1,MYL9,SORBS1,KEAP1,TGFB2,TUBA1C,ACTG1,ACVR1C,ARPC4,ACTN1	
PCP pathway	2.94E00	1.6666666666666667	2.06E-01	RSPO3,PFN1,JUN,VANGL1,DVL1,RAC1,MAPK10,MAPK9,DVL3,SDC4,SDC3,WNT5B,HSPB1	
Actin Cytoskeleton Signaling	3.04E00	3.2659863237109046	1.44E-01	PFN1,ARPC1B,PDGFA,FGF2,PIK3R1,ARPC5,HRAS,PDGFC,SLC9A1,CFL2,FLNA,PIK3CG,TMSB10/TMSB4X,MYL12B,ACTN1,MYL12A,CFL1,ARPC5L,GNA12,RAC1,GIT1,FGF1,PIK3R3,MYL9,TLN2,PIP5K1C,CD14,ARHGAP35,NCKAP1L,ACTG1,ARPC4	
Aldosterone Signaling in Epithelial Cells	3.06E00	1.507556722888818	1.58E-01	ICMT,PLCB2,CRYAB,HSPH1,PIK3R1,SLC12A2,HSPA9,HSPB8,DNAJC1,HSPA5,SLC9A1,HSPA2,HSPA8,PIK3R3,HSPA4,PLCE1,PIP5K1C,DNAJC4,DNAJB11,PIK3CG,HSPA13,SCNN1B,PI4KA,HSPB1	
Germ Cell-Sertoli Cell Junction Signaling	3.09E00	NaN	1.56E-01	TUBA1B,TGFBR1,PIK3R1,CTNNA1,HRAS,TUBB,RHOG,CFL2,SORBS1,KEAP1,PIK3CG,TGFB2,MTMR2,TUBA1C,ACTN1,RAB8B,CFL1,TUBB4B,TUBG1,TUBB2A,RAC1,MAPK9,PIK3R3,MAPK10,ACTG1	
RhoA Signaling	3.24E00	3.9000674757995495	1.72E-01	PLXNA1,PFN1,CFL1,SEPT9,ARPC1B,ANLN,SEPT3,ARPC5L,GNA12,ARPC5,PKN1,MYL9,CFL2,PIP5K1C,ARHGAP35,CDC42EP1,ACTG1,MYL12B,PI4KA,ARPC4,MYL12A	
Hypoxia Signaling in the Cardiovascular System	3.32E00	0.4472135954999579	2.15E-01	TP53,UBE2D2,JUN,EDN1,UBE2A,UBE2G1,NQO1,ATF4,UBE2E2,HIF1A,UBE2E1,UBE2D3,UBE2I,UBE2J2	
CD28 Signaling in T Helper Cells	3.44E00	2.5	1.78E-01	ARPC1B,ARPC5L,PIK3R1,CD4,ARPC5,HLA-DQA1,RAC1,MAPK9,HLA-DQB1,PIK3R3,PTPRC,CD28,FOS,CALM1 (includes others),JUN,PIK3CG,HLA-DRA,FCER1G,MAPK10,ARPC4,LCP2	
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes	3.49E00	3.771236166328254	1.94E-01	GAB2,PLD3,ARPC1B,ARPC5L,FCGR2A,PIK3R1,ARPC5,RAC1,FYB,PIK3R3,MYO5A,HMOX1,TLN2,PIK3CG,ACTG1,ARPC4,LCP2,FCGR3A/FCGR3B	
Signaling by Rho Family GTPases	3.7E00	3.401680257083045	1.50E-01	CDH18,SEPT9,ARPC1B,SEPT3,PIK3R1,ARPC5,SLC9A1,CLIP1,GNB1,RHOG,JUN,CFL2,PIK3CG,CYBB,ARHGEF2,CDC42EP1,GNG5,MYL12B,PI4KA,MYL12A,CFL1,ARPC5L,GNA12,GNG2,RAC1,MAPK9,PKN1,PIK3R3,MYL9,FOS,PIP5K1C,CDH20,MAPK10,ACTG1,ARPC4	
Clathrin-mediated Endocytosis Signaling	3.88E00	NaN	1.62E-01	APOE,RAB5C,APOB,ARPC1B,PDGFA,FGF2,PIK3R1,ARPC5,CLTB,SH3GLB1,AP1B1,PDGFC,LYZ,PIK3CG,AAK1,DAB2,STAM,S100A8,ARPC5L,RAB7A,RAC1,AP2S1,FGF1,HSPA8,PIK3R3,ITGB2,PIP5K1C,APOC1,ACTG1,ARPC4	
SAPK/JNK Signaling	3.91E00	1.885618083164127	2.02E-01	TP53,GNA12,PIK3R1,GNG2,MAPK8IP2,RAC1,HRAS,MAPK9,HNRNPK,GNB1,PIK3R3,JUN,DUSP10,PIK3CG,FCER1G,MAPK10,DUSP4,GNG5,MAP4K4	
IL-8 Signaling	3.92E00	4.270992778072193	1.63E-01	PLCB2,PIK3R1,HRAS,PDGFC,IRAK1,RAB11FIP2,GNB1,HMOX1,RHOG,JUN,CCND3,PIK3CG,ITGAV,CYBB,GNG5,MYL12B,VCAM1,PLD3,GNA12,GNG2,RAC1,MAPK9,CSTB,PIK3R3,MYL9,FOS,ITGB2,CCND2,MAPK10,MAP4K4	
Remodeling of Epithelial Adherens Junctions	5.42E00	2.4494897427831783	2.65E-01	TUBA1B,NME1,RAB5C,ARPC1B,ARPC5L,TUBB4B,TUBG1,TUBB2A,ARPC5,RAB7A,CTNNA1,TUBB,CLIP1,TUBA1C,ACTG1,MAPRE3,ACTN1,ARPC4	
Unfolded protein response	5.58E00	NaN	2.96E-01	DDIT3,ERN1,HSPH1,HSPA9,HSPA5,HSPA2,CEBPG,HSPA8,SEL1L,HSPA4,SREBF2,EDEM1,VCP,ATF4,NFE2L2,AMFR	
Regulation of eIF4 and p70S6K Signaling	5.96E00	0.0	2.05E-01	RPS3A,PIK3R1,RPS23,HRAS,RPS4X,EIF3B,RPS13,EIF3D,PIK3CG,RPS2,RPS12,RPS5,RPS24,RPS19,RPS8,RPS10,RPS21,RPS29,EIF2S2,FAU,PIK3R3,EIF3G,RPS15,RPS16,PTPA,RPS27L,EIF3I,RPS15A,PPP2R1B,RPSA	
tRNA Charging	6.08E00	NaN	3.59E-01	CARS,GARS,TARS,MARS,FARSB,FARSA,EPRS,NARS,WARS,YARS,FARS2,AARS,SARS,IARS	
Protein Ubiquitination Pathway	6.53E00	NaN	1.76E-01	CRYAB,PSMD7,UBE2A,PSMB10,USP5,HLA-A,HSPB8,TCEB2,HSPA5,UCHL1,HSPA4,DNAJC4,PSMA3,PSMD14,ANAPC11,AMFR,PSMB4,PSMA6,HSPH1,HSPA9,PSMC4,DNAJC1,PSMB6,HSPA2,PSMD8,HSPA8,PSMB7,UBE2D2,PSME1,PSMB2,DNAJB11,PSMD2,USP22,UBE2G1,RBX1,PSMA4,HSPA13,UBE2E2,USP46,UBA1,UBE2E1,UBE2D3,UBE2I,HSPB1,UBE2J2	
phagosome maturation	7.37E00	NaN	2.42E-01	TUBA1B,ATP6V0C,ATP6V0B,RAB5C,HLA-A,PRDX5,DYNLT1,TUBB,ATP6AP1,DYNLL1,HLA-DRA,CYBB,LAMP1,TUBA1C,RILP,TPO,NAPA,VPS11,TUBB4B,TUBG1,TUBB2A,RAB7A,ATP6V1A,GPAA1,DYNLRB1,ATP6V1E1,LAMP2,ATP6V1F,ATP6V1B2	
NRF2-mediated Oxidative Stress Response	7.7E00	3.4	2.11E-01	PIK3R1,MAF,HSPB8,HRAS,MAFG,HMOX1,JUN,DNAJC4,ABCC1,PIK3CG,KEAP1,VCP,UBE2K,ATF4,FMO1,GCLM,TXN,FKBP5,NFE2L2,CBR1,NQO1,MAPK9,DNAJC1,SOD1,TXNRD1,PIK3R3,FOS,FTL,ERP29,DNAJB11,RBX1,STIP1,AOX1,SQSTM1,ACTG1,GSTP1,FTH1,EPHX1	
mTOR Signaling	7.73E00	2.32379000772445	2.09E-01	RPS3A,PIK3R1,RPS23,FKBP1A,HRAS,HIF1A,PDGFC,RPS4X,HMOX1,RHOG,EIF3B,EIF3D,RPS13,PIK3CG,RPS2,RPS12,RPS5,RPS24,RPS19,RHEB,PLD3,RPS8,RAC1,RPS10,RPS21,RPS29,MLST8,FAU,PIK3R3,EIF3G,RPS15,RPS16,PTPA,RPS27L,EIF3I,RPS15A,INSR,PPP2R1B,RPSA	
EIF2 Signaling	1.64E01	4.811252243246881	2.88E-01	PIK3R1,RPS23,HRAS,EIF3B,RPS13,EIF3D,PIK3CG,RPL19,RPS2,PPP1CA,RPL36,EIF2AK1,RPL32,RPS8,RPL29,RPL12,RPL37A,EIF2S2,RPL28,PIK3R3,RPS15A,INSR,RPL41,RPSA,RPLP1,RPS3A,RPL26,RPL7A,RPS4X,RPL35,RPL18A,UBA52,RPS5,RPS12,RPL18,RPL31,RPS24,RPS19,RPL4,RPL17,RPL30,RPS10,RPS21,RPS29,FAU,EIF3G,RPS15,RPS16,RPS27L,EIF3I,RPL37,RPLP0,RPL38	
Mitochondrial Dysfunction	1.72E01	NaN	3.04E-01	NDUFA9,ATP5D,NCSTN,ATP5L,MT-CO2,NDUFA4L2,NDUFA1,MT-ND2,ATP5J,SURF1,SDHC,UQCR11,MT-ND4L,NDUFA6,MAPK10,NDUFA12,MT-ND3,NDUFS3,VDAC1,NDUFB2,NDUFA4,COX7B,SDHB,ATP5G1,PRDX5,NDUFA2,PARK7,MT-CYB,ATP5J2,MT-CO3,NDUFAB1,ATP5I,NDUFS4,MT-CO1,MT-ATP6,NDUFB4,COX17,MT-ND6,UCP2,COX7A2L,MAPK9,MT-ND4,NDUFA13,APP,FIS1,MT-ND1,MT-ND5,NDUFS8,NDUFA11,UQCR10,CYCS,UQCRQ	
Oxidative Phosphorylation	1.74E01	NaN	3.76E-01	NDUFA4,ATP5G1,COX7B,SDHB,NDUFA9,ATP5D,ATP5L,MT-CO2,NDUFA1,NDUFA2,MT-CYB,ATP5J2,MT-CO3,MT-ND2,NDUFAB1,ATP5I,NDUFS4,ATP5J,MT-CO1,COX17,MT-ATP6,NDUFB4,SURF1,COX7A2L,MT-ND4,UQCR11,SDHC,MT-ND4L,NDUFA13,MT-ND1,MT-ND5,NDUFS8,NDUFA11,UQCR10,NDUFA6,NDUFA12,CYCS,MT-ND3,NDUFS3,UQCRQ,NDUFB2	

Upstream Regulators for My Projects->David Bulger->P2
Analysis	ID	Upstream Regulator	Expr Fold Change	Molecule Type	Predicted Activation State	Activation z-score	Notes	Bias Term	Bias-corrected z-score	p-value of overlap	Target molecules in dataset	Mechanistic Network	
P2	 	sirolimus	 	chemical drug	Inhibited	-6.630	bias	-0.429	-2.407	1.99E-30	ANXA5,APP,ARF1,ARHGDIB,ASNS,ASS1,ATF4,ATP5G1,CCND2,CCND3,CD151,CD209,CRAT,CYCS,DAD1,DDIT3,DVL3,EGR1,ENO1,FAS,FOS,FTH1,G6PD,GSTP1,HIF1A,HMOX1,HSPA4,HSPA5,INSR,ISG15,LDHB,LEP,MAF,MAPT,MBP,NCAM1,NDUFA9,OAZ1,ODC1,PIK3R1,PKM,PLIN1,PLIN2,PPIA,PRDX5,PRNP,PSMA3,PSMA4,PSMA6,PSMB4,PSMB6,PSMB7,PSMD8,PYGB,RAB9A,RAN,RPL18,RPL18A,RPL19,RPL29,RPL30,RPL32,RPL35,RPL37,RPL37A,RPL38,RPL41,RPL7A,RPLP0,RPN2,RPS10,RPS12,RPS13,RPS15,RPS16,RPS19,RPS2,RPS21,RPS23,RPS24,RPS29,RPS3A,RPS4X,RPS5,RPS8,RPSA,SCD,SLC1A2,SLC1A5,SLC25A5,SLC38A3,SLC3A2,SNRPC,SNRPD2,SNRPF,SOCS3,SOD1,SQSTM1,STAT1,TARS,TIMP1,TOP2A,TPM3,TUBB2A,UBA1,UBA52,UCP2,VCAM1	Ap1,CREB1,FOS,FOXO1,HIF1A,Insulin,JUN,MTOR,MYC,NFKB1,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,TP53,nitric oxide,sirolimus	
P2	 	RICTOR	-1.184	other	Inhibited	-7.762	bias	-0.522	 	1.90E-28	ATP5D,ATP5G1,ATP5J,ATP5J2,ATP5L,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V1A,ATP6V1B2,ATP6V1E1,ATP6V1F,CD4,COX17,COX7A2L,COX7B,FAU,HIF1A,ISG15,LHPP,NDUFA1,NDUFA11,NDUFA2,NDUFA4,NDUFA4L2,NDUFA6,NDUFA9,NDUFAB1,NDUFB2,NDUFB4,NDUFC2,NDUFS3,NDUFS4,NDUFS8,POMP,PPA2,PSMA3,PSMA4,PSMA6,PSMB10,PSMB2,PSMB4,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD7,PSMD8,PSME1,RPL12,RPL17,RPL18,RPL26,RPL28,RPL30,RPL38,RPL4,RPL41,RPL7A,RPLP0,RPS10,RPS13,RPS15,RPS19,RPS2,RPS21,RPS23,RPS24,RPS29,RPS5,RPS8,RPSA,SDHB,SDHC,UQCR10,UQCR11,UQCRQ,VCAM1	 	
P2	 	5-fluorouracil	 	chemical drug	Inhibited	-3.613	bias	-0.303	-1.155	2.80E-27	AHSA1,ALDOA,ANXA2,ATF4,ATP5I,CAPNS1,CES2,COPS8,CSTB,CYCS,EGR1,EIF2S2,EIF3G,FAS,FBL,FGFR2,FKBP1A,GAPDH,GARS,GDF15,HNRNPAB,HSPA8,IARS,MAT2A,MT-CO1,MT-ND3,MT-ND4,MT-ND4L,MT-ND6,NACA,NDUFA1,NDUFA4,NDUFS8,OAZ1,PIK3CG,PKM,PSMA6,PSMB2,PSMB7,PSMD2,PSME1,RPL18,RPL19,RPL30,RPL31,RPL35,RPL37,RPL38,RPL7A,RPS13,RPS15A,RPS16,RPS23,RPS29,RPS4X,RPS8,SLC25A5,SLC25A6,SNRPD2,SNRPF,SQSTM1,SRM,SSR4,TCEB2,THBS1,TMSB10/TMSB4X,TNFRSF10B,TNFRSF12A,TP53,UNG,XPOT	5-fluorouracil,EGR1,JUN,MYC,NFKB1,NFKBIA,RB1,RELA,SP1,STAT1,TP53,TP63,TP73,VEGFA	
P2	 	beta-estradiol	 	chemical - endogenous mammalian	Activated	4.644	bias	0.264	0.888	7.54E-26	AARS,ABCA3,ACKR3,ADAMTS5,ADCY1,ADGRG2,ADIPOQ,ADORA1,AES,AGER,AIF1,ALCAM,ALDH4A1,ALDOA,ANO2,ANXA1,AP1B1,AP3D1,APOE,APP,ATF5,ATP2B1,ATP5I,ATP6V1F,BCAT1,BIN1,BTG2,CALM1 (includes others),CCND2,CCND3,CCNI,CCR1,CCT2,CD14,CD74,CLCN3,CLDN1,CLSTN2,CNBP,COL6A6,COMT,CPM,CSTB,CTPS1,CTSB,CTSD,CUBN,CXCL10,CXXC5,CYBB,CYP4B1,CYR61,DDIT3,DERL1,DMTN,DNAJC1,DNPH1,DPM2,DUSP10,DUSP4,DUSP6,DYNLL1,ECHDC2,EDN1,EGR1,EIF3B,EIF3D,EIF3G,EMG1,ENO1,EPB41L3,ESR2,FADS3,FAM162A,FARSA,FARSB,FAS,FCGR2A,FCGRT,FGF2,FGFR2,FHL1,FLOT1,FMO1,FOS,FOSB,FUCA1,G6PD,GAB2,GADD45B,GARS,GJB2,GM2A,GNB1,GNL3,GPC1,GSTP1,HDGF,HLA-A,HLA-DQA1,HMGCS1,HMOX1,HNRNPK,HOXA10,HRAS,HSPA2,HSPA4,HSPA5,HSPA8,HSPA9,HSPB1,HSPB8,HSPH1,HTRA1,IARS,IFI30,IGFBP4,IGSF6,IP6K3,IPO4,ISG15,ITGAV,ITGB2,JUN,KCND3,KIT,KLF4,KPNA2,KRT5,KRT6A,KRT6B,LAGE3,LAPTM5,LEP,LHCGR,LHFPL2,LITAF,LMCD1,LOC102724428/SIK1,LYZ,MAL2,MAPT,MBD4,MBP,MKI67,MMRN1,MPC1,MPEG1,MSMO1,MT-CO1,MT-CO2,NARS,NCAM1,NFE2L2,NHP2,NME1,NPR3,NPY1R,NR4A1,NR5A2,NTRK3,NUPR1,ODC1,PDGFA,PFKL,PHB2,PI3,PIK3R1,PIK3R3,PKM,PLAA,PLIN2,PLPP1,PNRC2,PPP1R9B,PRMT5,PSAT1,PSMB2,PTGFR,PTPRK,PTX3,QSOX1,RAB9A,RAC1,RAMP3,RAN,RET,RPL17,RPN2,RPS13,S100A2,S100A7,SAA1,SBF1,SDC3,SDC4,SEMA3C,SFRP1,SFRP4,SIAH2,SLC12A2,SLC14A1,SLC24A3,SLC39A6,SLC3A2,SLC7A2,SLC7A5,SLC9A1,SLC9A3R1,SLCO2B1,SMPD1,SNCG,SOCS3,SOX9,SQSTM1,SRD5A1,ST6GALNAC4,STC2,STIP1,STON1,STS,STXBP1,SYP,TARS,TESK1,TGFB2,TGFBR1,THBS1,THBS4,THRSP,THSD4,TIMP1,TMEM2,TOP2A,TOP3B,TP53,TPO,TRAF3,TSPO,TUBG1,TXN,TXNL4A,TXNRD1,VAPA,VCAM1,VPS11,WNT5B,YARS,YWHAH,ZNF91	AHR,Ap1,CEBPA,EGR1,ESR1,ESR2,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF,beta-estradiol,estrogen receptor	
P2	 	CD 437	 	chemical drug	Inhibited	-6.043	bias	-0.601	 	1.94E-24	AKR1B1,ALDOA,AP2S1,ARF1,ARHGDIB,ARL2,ARSA,ATP5J,ATP5L,ATP6V0C,BANF1,CCT2,COX7A2L,COX7B,EIF3D,EIF3G,EIF3I,EIF5A,ENO1,FAS,FKBP5,FOS,FTH1,FTL,GDF15,HSPA8,INO80B,JUN,KPNA2,MAN1B1,MTCH2,NACA,NARS,NME1,NR4A1,ODC1,PFN1,PGAM1,POLR2G,PSMA4,RBX1,RPL19,RPLP1,RPS10,RPS15,RPS16,RPS2,SH3BGRL3,SLC25A5,SLC25A6,SLIRP,SNRPD2,SNRPF,SOD1,SSBP1,STOML2,TIMM8B,TMSB10/TMSB4X,TNFRSF10B,TP53,TUBA1B,TXN,UBA52,UBL5	AHR,Ap1,CD 437,CREBBP,EGR1,FOS,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA	
P2	 	MYC	-1.418	transcription regulator	Activated	5.397	bias	0.283	2.277	3.98E-23	ACTN1,ALCAM,ALDOA,ANXA5,APP,ASNS,ASS1,ATF4,ATP13A2,BCAT1,BCOR,BIN1,BMPER,C12orf49,C1QBP,CAPN2,CAPNS1,CAPZB,CBX4,CCND2,CCND3,CD151,CHST15,CITED1,CNBP,COL15A1,COL5A2,COL8A1,COX7A2L,CRYAB,CSRP2,CST6,CSTB,CTNNA1,CTSB,CTSD,CXCL10,CYCS,DCTPP1,DDIT3,DNPH1,DUSP4,DUSP6,EDN1,EGR1,EIF2S2,EIF3D,EIF3G,ENO1,FAM129A,FAS,FBL,FCGRT,FECH,FKBP5,FLNA,FOS,FTH1,G6PD,GAA,GABARAP,GADD45B,GAPDH,GCLM,GFPT1,GLUL,GM2A,GOT1,GPC1,H2AFZ,HIF1A,HLA-A,HMGA1,HMOX1,HNRNPAB,HSPA9,HSPB1,HSPH1,IPO7,JUN,KLF4,KRT14,KRT6B,LAMP1,LAMP2,LDHB,LEP,LGMN,LSM4,LYZ,MAT2A,MBP,ME2,MGAT1,MIF,MKI67,MNT,MT-TY,MYBBP1A,MYL9,NARS,NCAM1,NDUFS4,NME1,NME2,ODC1,PEG10,PFKFB1,PFKFB3,PFKL,PGAM1,PHB2,PKM,PNO1,POLR2G,PPIA,PRKACB,PSAT1,PTPRC,RAB10,RPL19,RPL26,RPL30,RPL35,RPL41,RPL7A,RPLP1,RPS12,RPS15A,RPS16,RPS19,RPS23,RRM2B,RRP1B,SAE1,SCPEP1,SDCBP,SEPHS2,SERPINE2,SFRP1,SHMT2,SLC1A5,SLC25A5,SLC38A1,SLC3A2,SLC7A5,SNRPD2,SOX6,SOX9,SPP1,SRD5A1,SRM,SUMO3,TGFB2,THBS1,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TP53,TSPO,TXN,TXNRD1,UBA2,UBE2I,VCAM1	Ap1,CREBBP,EGR1,ELK1,ERK1/2,ESR1,ESR2,FOS,JUN,MYC,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT1,TP53,TP63,TP73,beta-estradiol	
P2	 	APP	2.506	other	Activated	3.005	bias	0.258	1.242	4.88E-22	ACTG1,AES,AGER,AIF1,AK1,ALDOA,APLP2,APOE,APP,ATF4,ATOX1,ATP5D,ATP5J,ATP6V1A,ATP6V1E1,C1QBP,CALML3,CAMK2D,CCND2,CD151,CD68,CD74,CFL1,CFL2,CLDN1,CLTB,CSF1R,CTSB,CTSD,CXCL10,CYBB,CYCS,DCX,EDN1,EGR1,ENG,ENO1,F2RL3,FAM49A,FBL,FCGR2A,FGF2,FKBP1A,FLNA,FOS,FOSB,GAPDH,GDF15,GNA12,GNB1,GNG2,GPC1,GSTP1,HCAR2,HINT1,HK1,HMGA1,HMOX1,HSPA5,HSPA8,HSPB1,INSR,IRF5,JUN,KCND3,KIF2A,LDHB,LHFPL2,LMO4,MAF,MAP1B,MAPKAPK2,MAPT,MBD4,MBP,MSR1,MT-ATP6,MT-CO1,MT-CO2,MT-CO3,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND4,MT-ND5,MT-ND6,MTHFD1L,NCDN,NDUFS4,NME1,NR1D1,NR4A2,PACS2,PAFAH1B2,PDGFA,PDXP,PEA15,PEBP1,PFKFB3,PGAM1,PIK3R1,PKM,PPIA,PRDX5,PRNP,PSME1,PTPA,PTPRC,RAN,RNF24,S100A8,SDC4,SIGMAR1,SIRPA,SLC1A2,SLC7A11,SLFN5,SOCS3,SOD1,SOX9,SREBF2,STIP1,STMN2,STXBP1,SYP,THSD4,TLR8,TNFRSF10B,TOP2A,TP53,TPM3,TPP1,TRAF3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UBE2K,UCHL1,UQCRQ,VCAM1,VDAC1	APOE,APP,ATF6,Ap1,CREB1,CTNNB1,HSF1,JUN,LDL,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PSEN1,RELA,SOD1,SP1,TP53,hydrogen peroxide	
P2	 	ST1926	 	chemical drug	Inhibited	-6.282	bias	-0.694	 	2.07E-21	AKR1B1,AP2S1,ARF1,ARSA,ATP5I,ATP5J,CCT2,CFL1,CHCHD2,COX7A2L,COX7B,DYNLL1,EIF3D,EIF3G,EIF3I,EIF5A,ENO1,FKBP5,H2AFZ,KPNA2,MAN1B1,MTCH2,NACA,NARS,NME1,ODC1,PFN1,POLR2G,PSMA4,RBX1,RPL18A,RPL19,RPL29,RPL32,RPL41,RPLP1,RPS10,RPS15,RPS2,SLC25A6,SLIRP,SNRPD2,SNRPF,SOD1,SSBP1,TIMM8B,TMSB10/TMSB4X,TNFRSF10B,TP53,TXN,UBA52,UBL5,VAMP8	 	
P2	 	PSEN1	1.415	peptidase	 	-1.825	 	-0.083	-1.419	3.37E-21	ACTG1,AGER,ALDOA,APOE,APP,ATOX1,ATP5D,ATP5J,ATP6V1A,ATP6V1E1,C1QA,C1QB,C1QBP,C1QC,C3AR1,CALML3,CAMK2D,CD74,CFL1,CFL2,CLTB,CTSS,CYCS,DCX,EGR1,ENO1,FBL,FKBP1A,FMN2,FOS,GADD45B,GAPDH,GAS5,GNA12,GNB1,GNG2,GSTP1,HINT1,HK1,HSPA5,HSPA8,INSR,IRF5,KIF5B,LFNG,MAPT,MBP,MFSD14A,MSR1,MT-CO1,MTHFD1L,NCAM1,NCSTN,NDUFS4,NME1,NUPR1,PAFAH1B2,PEA15,PEBP1,PGAM1,PIK3R1,PKM,PPIA,PRDX5,SLC1A2,SOD1,STAB1,STIP1,STMN2,STXBP1,SYP,TNFRSF10B,TNXB,TP53,TPM3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UCHL1,UQCRQ,VDAC1,WARS	APP,Ap1,CREB1,FOS,HIF1A,HSF1,HTT,JUN,L-glutamic acid,MTOR,NFE2L2,NFKBIA,NFkB (complex),PSEN1,RELA,SOD1,SP1,STAT1,TP53	
P2	 	MAPT	1.924	other	 	-0.816	 	0.048	-0.934	5.83E-19	ACTG1,AIF1,ALDOA,APP,ATOX1,ATP5D,ATP5J,ATP6V1A,ATP6V1E1,C1QBP,CALML3,CAMK2D,CFL1,CFL2,CLTB,CYCS,ENO1,FBL,FKBP1A,FOS,GAPDH,GLO1,GNA12,GNG2,GSTP1,HINT1,HK1,HSPA5,HSPA8,JUN,MAP1B,MAPT,MBP,MTHFD1L,NDUFS3,NDUFS4,NME1,NMNAT2,PAFAH1B2,PCLO,PEA15,PEBP1,PGAM1,PKM,PPIA,PRDX5,PRNP,SLC1A2,SLC1A3,SOD1,STIP1,STMN2,STXBP1,SYP,TPM3,TUBA1B,TUBA1C,TUBB,TUBB2A,TUBB4B,TXN,UCHL1,UQCRQ,VDAC1	APP,ATF6,Ap1,FOS,HIF1A,JUN,MAPT,MTOR,MYC,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,PSEN1,RELA,STAT1,TP53,nitric oxide	
P2	 	TNF	1.548	cytokine	Activated	4.581	bias	0.262	1.096	9.42E-19	ABCC1,ABCC3,ABR,ACKR3,ADAM17,ADAMTS5,ADIPOQ,ADORA1,AGER,AKR1B1,ALCAM,ALDH2,ALOX5AP,ANXA1,APOE,APP,ARHGDIB,ASS1,ATF4,ATP2B1,ATP5J,BAMBI,BHLHE41,BMPER,BTG2,BTG3,C1QTNF9,C3AR1,CCL28,CCND2,CCND3,CCR1,CD14,CD163L1,CD209,CD28,CD4,CD83,CEBPG,CHST11,CHST2,COL15A1,COL16A1,CPA3,CRYAB,CSF1R,CTSB,CTSS,CXCL10,CXCL16,CXCL9,CYBB,CYR61,DDIT3,DMD,DUSP10,DUSP4,DUSP6,DVL1,EDN1,EGR1,ENG,ENTPD5,ETV5,F2RL3,FAS,FBL,FCER1G,FCGRT,FGF2,FGFR2,FMO1,FOS,FOSB,FTH1,G0S2,GADD45B,GBP1,GCLM,GDF15,GM2A,GRN,GSPT1,GSTP1,HEXA,HIF1A,HLA-A,HLA-DRA,HMOX1,HSPA4,HSPA8,IGFBP4,IGKC,IL10RA,IL1RN,INSR,IRF5,ISG15,ITGAV,ITGB2,JUN,KCTD13,KIT,KLF4,KRT6B,LAMP3,LEP,LGALS9,LHCGR,LITAF,LRRC8D,MAP4K4,MAT2A,MBP,MIF,MNT,MPC1,MSC,MSR1,MT-CO2,MT-CO3,MT-CYB,NAGLU,NCAM1,NFE2L2,NINJ1,NME1,NNMT,NQO1,NR4A1,NR4A2,NR5A2,NRROS,ODC1,PCK2,PCSK6,PDE8B,PDGFA,PI3,PIK3CG,PIM3,PKM,PLA2G2A,PLAA,PLD3,PLIN1,PLIN2,PLPP1,PLXNB2,PPP2R1B,PRNP,PSMB10,PSME1,PTGFR,PTPRC,PTX3,RAB32,RAC1,RARRES3,RASD1,RNASE1,RPS13,RPSA,RRM2B,S100A7,S100A8,SAA1,SCD,SCNN1B,SCO2,SCUBE1,SDC4,SEMA3C,SERPINE2,SFRP1,SLC14A1,SLC1A2,SLC1A3,SLC1A4,SLC35B2,SLC7A1,SLC7A2,SLCO2B1,SMPD1,SNCG,SOCS3,SOD1,SORBS1,SOX9,SPP1,SQSTM1,SRA1,ST3GAL6,STAT1,SYTL1,TALDO1,TGFB2,TGFBR1,THBS1,THRSP,TIMP1,TLR8,TMEM176B,TNFRSF10B,TP53,TPO,TRAF3,TREM2,TUB,TXN,TXNRD1,TYMP,UCK1,UCP2,VCAM1,WHSC1,YWHAG,ZNF330	AHR,CEBPA,CEBPB,CREBBP,IFNG,IL1B,IL6,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,TNF,TP53	
P2	 	dexamethasone	 	chemical drug	Inhibited	-2.665	 	0.129	-4.390	1.64E-18	AACS,ABCC1,ABCC3,ACKR3,ACTG1,ADAM12,ADAM17,ADAMTS15,ADIPOQ,AKR1C1/AKR1C2,AKR1C3,ALAS1,ALCAM,ALDH4A1,ALOX5AP,ANOS1,ANXA1,APOE,APP,ARHGDIA,ARHGEF2,ASNS,ASPH,ATF4,ATP2B1,ATP6V1B2,B3GNT5,BCKDK,BTG2,BZW2,C1QB,C3AR1,C9orf72,CARS,CBR1,CCND2,CCND3,CCR1,CD209,CD74,CD83,CES1,CES2,CFL1,COL15A1,CPEB4,CREG1,CRISPLD2,CRYAB,CSF1R,CSNK1A1,CTSB,CTSD,CXCL10,CXCL14,CYBB,CYP3A5,CYP4A11,CYR61,DDIT3,DTYMK,DUSP10,DUSP4,EDEM1,EDN1,EGR1,EPB41L4B,ESR2,ETV5,EYA2,FAM129A,FAM89B,FANCE,FGF2,FKBP2,FKBP4,FKBP5,FMO1,FOS,FOSB,FTH1,FTL,G0S2,G6PD,GADD45B,GAPDH,GBP1,GCLM,GDF15,GLUL,GOT1,GRN,GSTP1,GUK1,HADHB,HLA-A,HLA-DQB1,HMGA1,HMOX1,HNRNPAB,HOXA7,HPCAL1,HSPA5,HSPA8,HSPH1,IGFBP4,IL10RA,IL1RN,INSR,IP6K3,IRAK1,IRF5,ITGAV,JUN,KIT,KPNA2,KRT14,LAGE3,LAPTM5,LEP,LITAF,LMO4,MAF,MAT2A,MBP,ME1,MIF,MSR1,MT-CO2,MT-CO3,MYOC,NCAM1,NDUFA4L2,NFE2L1,NHLH1,NPR3,NR2F6,NR4A1,ODC1,P2RX7,P4HA2,PCDH19,PCIF1,PCK2,PCSK6,PDGFA,PEBP1,PER1,PFKFB3,PHLDA2,PI3,PIK3R1,PLEK,PLIN1,PLOD3,PNRC2,POMGNT1,PPA2,PRELP,PSAP,PTX3,RARRES3,RASD1,RCC2,RET,RPL26,RPLP0,RPS23,S100A8,SAA1,SAA2,SCD,SCNN1B,SDHC,SEC61A1,SERPINE2,SFRP1,SHB,SLC14A1,SLC1A2,SLC25A1,SLC25A5,SLC2A5,SLC30A2,SLC40A1,SLC7A6,SLC9A1,SLCO2B1,SNRPC,SOCS3,SOD1,SOX9,SPP1,SRM,SRPRA,STAT1,STON1,TAF6,TGFB2,TGFBR1,THBS1,THRSP,TIMP1,TLR8,TMEM176B,TNFRSF10B,TNS1,TOP2A,TP53,TRIM31,TRPM6,TSN,TSPAN33,TXN,UBE2D2,UBE2G1,UCP2,VCAM1,VCP,WARS,ZBTB16,ZNF91	CEBPA,CEBPB,CREBBP,EGR1,FOXO1,IFNG,IGF1,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,TNF,dexamethasone,troglitazone	
P2	 	MYCN	-6.174	transcription regulator	Activated	4.950	 	0.149	3.819	8.98E-18	ABCC1,ACTG1,ALDOA,ARPC1B,CCND2,CKAP4,COL5A2,COL8A1,CTDNEP1,EEF1D,EIF5A,FAU,FGFR2,GAPDH,HLA-A,HMGA1,MRC2,MYL12A,NACA,NCAM1,NME1,NME2,ODC1,PSMB6,PSMB7,RPL12,RPL17,RPL18,RPL18A,RPL19,RPL26,RPL28,RPL29,RPL30,RPL31,RPL35,RPL37,RPL37A,RPL38,RPL4,RPL41,RPLP0,RPLP1,RPS12,RPS13,RPS15,RPS16,RPS19,RPS2,RPS23,RPS24,RPS3A,RPS4X,RPS5,RPS8,SLC1A2,TNFRSF10B,TP53,TUBA1B,TUBB,UCHL1	 	
P2	 	dihydrotestosterone	 	chemical - endogenous mammalian	Activated	2.726	bias	0.348	0.529	9.53E-18	ACKR3,ADIPOQ,AES,ALAS1,ALDOA,APOE,APP,ATP13A2,BCAP31,BCOR,BTG2,CA3,CCND2,CCND3,CCNI,CD63,CD74,COL5A2,COL5A3,CST6,CYBB,CYP4A11,CYP4B1,DCTPP1,DPM3,DYNLL1,EGR1,ENO1,ESR2,FAM89B,FGF2,FKBP5,FOS,FTH1,FTL,G0S2,GAPDH,GLUL,GRN,GSTP1,HINT1,HIST1H3J,HLA-A,HSPB1,IGFBP4,INSR,JUN,KPNA1,KRT14,KRT5,LEP,LYZ,MAF,ME1,MT-CO1,MT-CO2,MT-CO3,MT-CYB,MT-ND3,MT-ND4,NR4A1,ODC1,PEA15,PER1,PFN1,PIP,PRNP,RPL12,RPL19,RPL28,RPL30,RPL37A,RPS12,RPS23,RPS24,RPS29,SCD,SDC3,SEL1L,SERPINE2,SFRP4,SLC1A3,SLC1A4,SLC1A5,SLC2A5,SLC3A2,SLC7A6,SPP1,SRD5A1,SREBF2,STXBP1,SYP,TALDO1,TGFB2,TGFBR1,THBS1,TP53,VCAM1	AGT,Ap1,CEBPB,CTNNB1,EGF,EGR1,ESR1,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,STAT1,TP53,cyclic AMP,dihydrotestosterone,estrogen receptor,progesterone	
P2	 	D-glucose	 	chemical - endogenous mammalian	 	0.239	 	0.152	-1.094	2.03E-17	AARS,ADAM17,ADIPOQ,AGER,AKR1B1,ALDOA,ANLN,ANXA1,APOB,ASNS,ASS1,ATF4,ATF5,ATP2B1,BCAT1,CARS,CCND2,CCND3,CCPG1,CLGN,CTSB,CYBB,DDIT3,DNAJB11,EDN1,EGR1,ENO1,FAS,FGF2,FKBP2,FOS,G6PD,GAPDH,GDF15,GFPT1,GIPR,GLUL,GOT1,GRN,HIF1A,HK1,HMOX1,HNRNPK,HSPA5,HSPB1,INSR,JUN,KIF5C,LEP,MDH2,MIF,MSR1,MT-ND1,NDUFA1,NFE2L2,NPY1R,NQO1,NR4A1,NR4A2,ODC1,PCCB,PCK2,PDIA6,PFKFB3,PFKL,PGAM1,PREB,RTN3,SARS,SCD,SDHB,SEC61A1,SEPHS2,SLC1A3,SLC25A1,SLC25A5,SLC39A6,SLC3A2,SLC7A1,SORBS1,SOX9,SPP1,SQSTM1,SRM,SRPRA,STXBP1,TALDO1,THBS1,THRSP,TIMP1,TP53,TXNRD1,UCP2,VCAM1,WARS,YARS	AGT,CEBPA,CEBPB,CREB1,D-glucose,DDIT3,FOXO1,HIF1A,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,dexamethasone,palmitic acid	
P2	 	NFE2L2	2.071	transcription regulator	Activated	6.172	bias	0.475	2.045	5.00E-17	ABCC1,ABCC3,ACTG1,ALAS1,ALDOA,AOX1,ARF1,ATF4,CBR1,CREG1,CTSD,CXCL10,CYBB,DAD1,DDIT3,DNAJB11,DYNLL1,EIF3G,ENTPD5,EPHX1,ERP29,FKBP5,FMO1,FTH1,FTL,G6PD,GBE1,GCLM,GSPT1,GSS,GSTP1,HAX1,HMBS,HMOX1,HSPA9,IL1RN,KEAP1,MAFG,MAPK10,ME1,MSMO1,NARS,NFE2L1,NFE2L2,NQO1,NSMF,OSGIN1,PDIA6,PGD,PIP5K1C,PSAT1,PSMA4,PSMA6,PSMB2,PSMB4,PSMB6,PSMD14,PSMD7,RAMP2,RAN,RPL18,RPLP0,RPS16,SAA1,SEC61A1,SLC1A4,SLC7A11,SOCS3,SOD1,SQSTM1,STIP1,SYP,THRSP,TP53,TUB,TXN,TXNRD1,UBE2K,VCAM1,VCP	BACH1,CEBPA,HMOX1,IL1B,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,P38 MAPK,RELA,SP1,STAT1	
P2	 	1,2-dithiol-3-thione	 	chemical reagent	Activated	6.158	bias	0.534	 	4.40E-16	ABCC3,ACTG1,ALAS1,ALDOA,ARF1,CBR1,CREG1,CTSD,DAD1,DNAJB11,DYNLL1,EIF3D,EIF3G,ENTPD5,EPHX1,ERP29,FKBP5,FMO1,FTH1,GBE1,GCLM,GSPT1,GSTP1,HAX1,HMBS,HMOX1,MSMO1,NARS,NFE2L2,NQO1,PDIA6,PSAT1,PSMA4,PSMA6,PSMB2,PSMB4,PSMB6,PSMD14,PSMD7,PSMD8,RAN,RPL18,RPLP0,RPS16,SAA1,SEC61A1,SOD1,STIP1,THRSP,TXN,TXNRD1,UBE2K,VCP	1,2-dithiol-3-thione,BACH1,NFE2L2,NFkB (complex),RELA	
P2	 	lipopolysaccharide	 	chemical drug	Activated	5.155	bias	0.369	0.291	1.47E-15	ABCC1,ABCC3,ACKR3,ADIPOQ,ADORA1,AGER,ALCAM,ALDH2,ALOX5AP,ANXA1,ANXA5,ANXA7,APOB,APOC1,APOE,APP,ARPC1B,ASS1,ATP2B1,ATP5G1,ATP6AP1,BAMBI,C3AR1,CALM1 (includes others),CAPN2,CCND2,CCNI,CCR1,CD14,CD160,CD163L1,CD209,CD28,CD4,CD53,CD74,CD83,CLDN1,COL5A2,COL5A3,CRYAB,CSF1R,CSTB,CTSB,CUBN,CXCL10,CXCL14,CXCL16,CXCL9,CYBB,CYCS,CYP3A5,CYP4A11,CYR61,DDIT3,DNAJB11,DUSP4,EDN1,EGR1,ENO1,ERN1,ETV5,FAS,FCER1G,FCGRT,FGF2,FOS,FOSB,FTH1,FYB,G0S2,G6PD,GABARAP,GADD45B,GBP1,GJB2,GLIS2,GPC4,GSTP1,HADHB,HCAR2,HDGF,HIF1A,HLA-A,HLA-DQA1,HLA-DQB1,HMGA1,HMOX1,HSPA5,HSPA8,HSPB1,HTRA1,HYOU1,IGFBP4,IGKC,IGSF6,IL10RA,IL17RA,IL1RN,IL20RB,IL2RG,INSR,IRAK1,IRF5,ISG15,ITGA8,ITGAV,ITGB2,JUN,KIT,KLF4,LAMP3,LCP2,LEP,LGALS9,LITAF,LYZ,MAF,MAP4K4,MAPK9,MAPT,MIF,MKI67,MSC,MSR1,MT-CO1,MYL9,NNMT,NQO1,NR4A1,NR4A2,NR5A2,NUPR1,ODC1,PANX1,PARK7,PCSK6,PDE1C,PDGFA,PFKFB3,PHLDB2,PI3,PIK3AP1,PIK3CG,PIK3R1,PLA2G2A,PLAA,PLEK,PLIN2,PPIA,PRDX5,PSMA6,PSMB10,PSMB4,PSME1,PTX3,RAN,RARRES3,S100A2,S100A8,SAA1,SAA2,SCNN1B,SCUBE1,SDC4,SERPINE2,SIRPA,SLC1A5,SLC39A6,SLC3A2,SLC40A1,SLC7A11,SLC9A1,SNX12,SOCS3,SOD1,SPP1,SSBP1,STAT1,STIM1,STS,STXBP1,SYP,TALDO1,TGFB2,THBS1,THRSP,TIMP1,TLR8,TMSB10/TMSB4X,TOLLIP,TOP2A,TP53,TRAF3,TREM2,TSPO,TUBB4B,TXN,TYMP,TYROBP,UBA1,UBE2I,UCHL1,UCP2,VCAM1,VSIG4,WARS,YWHAG	CEBPA,CEBPB,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,lipopolysaccharide	
P2	 	DAP3	1.484	other	Inhibited	-3.606	bias	0.721	 	1.61E-15	MT-ATP6,MT-ATP8,MT-CO1,MT-CO2,MT-CO3,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND4,MT-ND4L,MT-ND5,MT-ND6	 	
P2	 	EIF2AK3	-1.661	kinase	 	1.322	bias	0.583	 	4.18E-15	AARS,ASNS,ATF4,ATF5,BTG2,CARS,CBX4,CEBPG,CLCN3,DDIT3,EGR1,EPRS,FGF2,HSPA5,HSPA9,IARS,JUN,KLF4,LMO4,LONP1,MECR,NARS,NUPR1,PCK2,SARS,SEL1L,SHMT2,SIAH2,SLC1A4,SQSTM1,TARS,TP53,WARS,YARS	EIF2AK3,ERN1,FOXO1,Gsk3,HIF1A,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP63,TP73,XBP1,reactive oxygen species	
P2	 	TP53	1.860	transcription regulator	Activated	3.210	 	0.151	1.429	4.24E-15	ABCC1,ABHD4,ACP2,ACSL3,ACTN1,ADCK3,AHSA1,AIFM2,AK1,AKR1B1,ALDH4A1,ANLN,ANXA1,ANXA2,AP1B1,APOE,APP,ARHGEF2,ARPC1B,ASNS,ASS1,ATF4,BCAP31,BHLHE41,BTG2,C1QC,CAMK2D,CAPNS1,CARS,CCND2,CCND3,CERS6,CES2,CISD1,CKAP2,COL5A2,COMT,CRYAB,CSF1R,CSTB,CTSB,CTSD,CYR61,DDIT3,DUSP4,DUSP6,EDN1,EGR1,ENG,EPHX1,FAS,FGF2,FHL1,FKBP1A,FKBP4,FKBP5,FMO1,FOS,FUCA1,G6PD,GAPDH,GBP1,GDF15,GLB1,GLIPR1,GLUL,GNL3,GSTP1,H2AFZ,HADHB,HIF1A,HLA-DQA1,HMGCS1,HMOX1,HRAS,HSPA8,HSPB1,HSPH1,IFI30,IGFBP4,IL10RA,IL17RA,INSR,IPO7,IRF5,ISG15,JUN,KCNG1,KCNMA1,KIT,KLF4,KPNA2,KRT14,LYPLA1,LYZ,MAPRE3,MDH2,ME1,ME2,MKI67,MOCOS,MT-CO2,MT-CYB,MT-ND5,MVD,MYL9,NAP1L4,NARS,NDUFA4L2,NEO1,NINJ1,NLRC4,NME1,NUPR1,OSGIN1,PAFAH1B2,PARK7,PCCA,PDGFA,PDIA6,PEG10,PFKFB3,PFN1,PHLDA3,PIK3R1,PIK3R3,PLTP,PLXNB2,POLD2,PPP1CA,PPT1,PRELID1,PRNP,PROSC,PSAP,PSMD2,PSMD8,RAP2A,RARRES3,RPN2,RPS27L,RPSA,RRM2B,S100A2,SCO2,SCPEP1,SEC61A1,SEC61B,SEL1L,SEMA3C,SERPINE2,SESN2,SFRP1,SGPL1,SLC19A1,SLC5A3,SOD1,SORBS1,SPP1,STAT1,STEAP3,STIP1,TGFB2,TGFBR1,THBS1,TMEM127,TMSB10/TMSB4X,TNFRSF10B,TOP2A,TP53,TPP1,TRIB3,TRIM28,TSPO,TUBB,UBA1,UNC5B,UNG,VAPA,WNT5B,WSB2,YWHAH	Ap1,CEBPB,EGR1,ELK1,ESR1,FOS,GATA1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,SNAI1,SP1,TNF,TP53,TP63,TP73	
P2	 	TGFB1	1.841	growth factor	Activated	4.465	 	0.246	1.597	4.32E-14	AASS,ACSL3,ACTN1,ADAM12,ADAM17,ADGRG2,ADIPOQ,ADORA1,AK1,AKR1C1/AKR1C2,ALDH2,ALDH3A2,ALDH5A1,ALOX5AP,ANXA2,APOB,APOE,APP,ARHGAP35,ASNS,ASS1,ATF4,BAMBI,BARD1,BIN1,C1QA,C1QB,C1QC,C20orf24,C3AR1,CALM1 (includes others),CALML3,CAPNS1,CARS,CCDC85B,CCND2,CCND3,CCR1,CCT2,CCT5,CD14,CD28,CD4,CD68,CD83,CFL1,CHST11,COL16A1,COL8A1,CSF1R,CSRP2,CTPS1,CTSB,CTSD,CTSS,CXCL10,CYBB,CYR61,DAB2,DAD1,DMTN,DUSP4,DYNLL1,EDN1,EGR1,ENG,EPRS,ESR2,F13A1,FAS,FCER1A,FCER1G,FCGR3A/FCGR3B,FGF2,FGFR2,FHL1,FLNA,FLRT1,FOS,FOSB,FTH1,FTL,GADD45B,GARS,GBP1,GDF15,GJB2,GNG2,HCAR2,HDGF,HEXA,HIF1A,HINT1,HLA-DQA1,HLA-DQB1,HLTF,HMGA1,HMOX1,HOXB5,HSPA5,HSPB1,HTRA1,IARS,IFI30,IGFBP4,IL10RA,IL1RN,ITGA7,ITGAV,ITGB2,JUN,KCNG1,KCNJ3,KDM6B,KIT,KLF4,KRT10,KRT14,LANCL1,LEP,LHCGR,LITAF,MAF,MAPKAPK2,MFAP4,MKI67,MRPS6,MS4A2,MSMO1,MSR1,MVD,MYL12A,NCAM1,NDUFS4,NME1,NMNAT2,NNMT,NPAS2,NPTXR,NR4A1,NR4A2,NRBP1,NUPR1,PCCB,PDGFA,PDLIM4,PHLDA2,PNO1,PPFIBP2,PPP1R1B,PPT1,PTPRC,PTPRK,RAB9A,RAC1,RAMP2,RNH1,RPN2,S100A11,SAE1,SCD,SDC4,SEC61B,SERPINE2,SFRP1,SHOC2,SLC1A2,SLC4A2,SLC7A1,SLC7A5,SOCS3,SOX9,SPP1,SRM,STAT1,STC2,STOML2,SYP,TAX1BP3,TENM4,TGFB2,TGFBR1,THBS1,TIMP1,TMEM184B,TNFRSF12A,TOP2A,TP53,TPM3,TPSAB1/TPSB2,TPST2,TUBB2A,TUBB4B,TXNRD1,TYMP,VAT1,VCAM1,VPS11,WNT5B,XPNPEP2,XYLT1	Ap1,CEBPB,EGR1,ELK1,ESR1,FGF2,IFNG,IRF8,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TGFB1,TNF,TP53	
P2	 	ATF4	1.895	transcription regulator	Activated	4.431	bias	0.603	 	5.34E-14	AARS,ASNS,ATF4,ATF5,BCAT1,CEBPG,CHAC1,DDIT3,EDN1,EIF2S2,GARS,GDF15,GHITM,GYS1,HSPA5,IARS,JUN,KLF4,MARS,NARS,NUPR1,PCK2,PSAT1,PTX3,SARS,SEL1L,SHMT2,SIGMAR1,SLC1A5,SLC38A3,SLC3A2,SLC7A1,SLC7A5,STC2,TNFRSF10B,TNFRSF12A,TRIB3,WARS,XPOT	ATF4,DDIT3,NFkB (complex)	
P2	 	tretinoin	 	chemical - endogenous mammalian	Activated	5.200	 	0.249	2.230	7.40E-14	ADAMTS5,ADCYAP1R1,ALAS1,ALPL,ANXA1,ANXA2,ANXA5,APOE,APP,ASNS,ATF4,ATP6V1B2,BAMBI,BTG2,C1QA,C3AR1,CALM1 (includes others),CALML3,CAPN2,CBR1,CCND2,CCND3,CCPG1,CCR1,CCT5,CD14,CD52,CD53,CD63,CD68,CD74,CEBPG,CES1,CIDEA,CLDN1,CRAT,CREG1,CSF1R,CSNK1A1,CSRNP1,CTSB,CTSD,CTSS,CUBN,CXCL10,CYBB,CYP4A11,CYP4B1,CYP4F11,CYR61,DAB2,DAD1,DAPK2,DCX,DDAH2,DDIT3,DSG1,DUSP4,DYNLL1,EDN1,EEF1D,EFS,EGR1,EIF3B,EPHX1,EYA2,FARSB,FCER1G,FGF2,FLRT1,FOLR2,FOS,G0S2,GARS,GDE1,GDF15,GM2A,GNA12,GSTP1,HDGF,HK1,HLA-A,HMGA1,HMOX1,HNRNPK,HOXB5,HSF4,HSPA2,HSPB1,IGFBP4,IL10RA,ISG15,ITGB2,JUN,KIT,KRT14,KRT5,LAMP2,LGALS9,MAP1B,MAPK10,MAPK9,MAPKAPK2,MSC,NAA10,NCAM1,NDUFA13,NLRC4,NME2,NPC2,NTRK3,ODC1,P2RX7,P4HA2,PDLIM4,PEG10,PFN1,PGD,PIK3CG,PLCB2,PLCE1,PLEK,PLEKHO2,PLIN2,PLOD3,POR,PPP1R1B,PRNP,PSMB10,PSMC4,PTPRC,PTX3,RAN,RAP2A,RARRES3,RET,RFLNB,RNASE1,RPL4,RPS12,RPS16,RPS19,S100A8,SCD,SCPEP1,SDCBP,SERPINE2,SFRP1,SIRPA,SLC12A2,SLC5A3,SLC7A2,SLFN5,SMPD1,SOD1,SOX6,SOX9,SPP1,STAT1,STT3A,TAF6,TGFB2,TGFBR1,THBS1,THSD4,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TOP2A,TP53,TPP1,TSPAN33,TYROBP,UBA1,UBE2D3,UCP2,VCAM1,VSIG4,WSB1,ZBTB16	Ap1,CEBPA,CEBPB,EGR1,FOS,IFNG,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TGM2,TNF,tretinoin	
P2	 	ciprofloxacin	 	chemical drug	 	-0.926	 	0.013	-1.004	1.48E-13	ABCB6,ACTN1,ALDH2,APP,ATP6V1A,ATP6V1B2,ATP6V1E1,CCR1,CD68,CTSA,CTSD,GBA,GRN,HLA-A,HSPA9,LGMN,LONP1,MPEG1,MSR1,MTHFD1L,MYBBP1A,PLXNB2,PSAP,RPL12,RPL7A,RRAGC,SHMT2,SPP1,SPRED1,SRPRA,STAB1,STXBP1,TTYH3,VDAC1	 	
P2	 	IFNG	1.442	cytokine	Activated	5.573	bias	0.323	1.734	2.02E-13	ADGRG2,ADIPOQ,ADORA1,AGER,AGPAT1,AIF1,ALOX5AP,APP,ASNS,ASS1,ATF4,C1QA,C1QB,C1QC,CCL28,CCND2,CCR1,CD14,CD163L1,CD2,CD209,CD4,CD63,CD74,CD83,CECR1,CERS6,CHAC1,CHST11,COL5A2,CSF1R,CTSB,CTSD,CTSS,CXCL10,CXCL16,CXCL9,CYBB,DDIT3,DEGS1,EDN1,EGR1,ERAP2,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FECH,FGF1,FGF2,FKBP5,FOS,FOSB,FTH1,FTL,GBP1,GDF15,GJB2,GLUL,GNG2,HCAR2,HIF1A,HLA-A,HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-G,HMGA1,HMGCS1,HMOX1,HSPA8,HSPB1,HTRA1,IFI30,IGFBP4,IGLC1,IL10RA,IL17RA,IL1RN,IRAK1,IRF5,ISG15,ITGAV,ITGB2,JUN,KCNMA1,KLF4,KRT14,LAMP3,LCP2,LEP,LGALS9,MAT2A,MIF,MSR1,NCAM1,NFE2L1,NQO1,NR1D1,NR5A2,NUPR1,ODC1,PANX1,PDGFA,PEA15,PIM3,PLA2G2A,PLEK,POMP,PPIA,PPP1R1B,PRNP,PSMA4,PSMA6,PSMB10,PSME1,RARRES3,RBCK1,RRAGD,S100A7,S100A8,SBF1,SCNN1B,SCUBE1,SDC4,SEPT3,SFRP1,SHB,SLC12A2,SLC14A1,SLC1A2,SLC1A3,SLC40A1,SLC4A2,SLC7A11,SLC7A5,SLFN5,SOCS3,SPP1,SQSTM1,SREBF2,SSBP1,STAT1,SYNM,TAPBPL,TGFB2,TGFBR1,THBS1,THEMIS2,TIMP1,TLR8,TNFRSF10B,TNFRSF12A,TP53,TPO,TREM2,TYMP,TYROBP,UBA2,UBE2E1,UNC5B,VCAM1,WARS,ZBTB16	CEBPA,CREBBP,IFNG,IL10,IL1B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	genistein	 	chemical drug	Activated	4.627	 	0.207	2.922	3.27E-13	ACP2,AKR1C3,ALAS1,ALDH5A1,AP1B1,APOB,ARSA,ATP6AP1,ATP6V0B,ATP6V1A,BMP2K,BTG3,C17orf75,CD4,CD68,CD74,CLCN7,CTSA,CTSB,CTSD,CTSG,CXCL10,DNASE1L3,DNPH1,ESR2,FOS,FUCA1,GABARAP,GBA,GDF15,GFPT1,GJB2,GLB1,GM2A,HEXA,HIF1A,HLA-A,HLA-DQA1,HMOX1,HOXA10,HS2ST1,HSPA5,ITGB2,JUN,KRT14,LAMP1,LAPTM5,LCP2,LGMN,MAL2,MMRN1,NAGLU,NFE2L2,NPC2,PER1,PIK3R1,PLBD2,PLTP,PPT1,PSAP,RPN2,RRAGC,SCPEP1,SLC1A5,SMPD1,SPP1,SQSTM1,TP53,TPP1,VCAM1,VPS11,XYLT1	Ap1,CREBBP,ERK1/2,FOS,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SRC,STAT1,TFEB,genistein	
P2	 	IL3	-4.368	cytokine	Activated	3.076	bias	0.520	 	5.61E-13	ALDH2,ALOX5AP,ARHGDIB,ATF5,BTG2,C1QA,CAPZB,CCND2,CCND3,CCT5,CD14,CD53,CD63,CD83,CEBPG,CIAPIN1,COPS4,CRAT,CSF1R,CSNK1A1,CXCL9,DAD1,DDIT3,EGR1,EIF3G,FAS,FCER1A,FCGR2A,FOS,GADD45B,HDGF,HK1,HLA-A,HSPA2,HSPA5,HSPA9,ITGAV,JUN,LAMP3,MS4A2,NACA,NARS,ODC1,PFKL,PLCB2,PSMB7,PSMC4,PSME1,RAN,RPL4,RPS12,RPS16,RPS19,SLC3A2,SNRPD2,SOCS3,SOD1,SSBP1,STT3A,TARS,TPSAB1/TPSB2,UCP2,VCAM1,YWHAG	Ap1,CREBBP,EGR1,FOS,IL10,IL3,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	HNF4A	-5.345	transcription regulator	 	-0.070	 	0.244	-1.245	6.07E-13	AASS,ABCC3,ABCF3,ACP2,ACSS3,ACTN1,ACTR1A,ADCK3,ADGRB2,AGPAT1,AHSA1,AIP,AJUBA,AKR1B1,AKR1C1/AKR1C2,AKR1C3,ALDH2,ALDH5A1,ANXA5,APOB,APOC1,APOE,ARPC5,ATF4,ATG9A,ATP10A,ATP6V0C,ATP6V1F,BARD1,BMP2K,BRF2,C12orf49,C5orf22,CAMK2D,CBX3,CES2,CFL2,CHCHD2,CHD1L,CLDN1,CLPTM1,CMC2,CNBP,COASY,COMMD9,COPS7A,COPS8,COX14,COX7A2L,CRAT,CTDNEP1,CTSA,CTSB,CYP3A5,DAD1,DDX49,DERL1,DHRS7B,DHX8,DNPH1,DPM2,DUSP6,EGR1,ELP5,EMG1,EPB41L4B,EPHX1,FARSB,FAS,FHL1,FLNA,FLOT1,FN3KRP,G0S2,G3BP2,G6PD,GAPDH,GBE1,GDF15,GHITM,GJB2,GLYAT,GNG5,GNL3,GOT1,GPR137,GSPT1,GSS,GUF1,GYS2,HADHB,HEXA,HIF1A,HLA-G,HNRNPA0,HSPA5,HSPH1,IFI30,IGSF8,IL10RA,JTB,JUN,KIF3B,KRT10,KRT14,LARP4,LSM4,MAL2,MAPK8IP2,MAT2A,MBD4,MDH2,MOCOS,MRPL24,MRPL37,MRPL51,MRPS15,MTMR2,NAA10,NAPA,NDUFA1,NDUFA4,NDUFS3,NDUFS4,NFE2L1,NME1,NMNAT2,NR1D1,NR5A2,OSBPL11,PCK2,PEG10,PEX3,PHB2,PHPT1,PIK3R3,PKM,PLAA,PNMA1,PNO1,POLRMT,PPFIBP2,PPIL1,PPP1CA,PPP1R11,PRDX5,PRELID3B,PSAT1,PSMA3,PSMB7,PSMC4,PSMD7,PSMD8,RAB10,RAB7A,RBM18,RNF44,RNPEPL1,RPL12,RPL18,RPL18A,RPL31,RPL41,RPLP1,SAA1,SAA2,SCD,SDF2,SEC61B,SEL1L,SEMA3C,SESN2,SF3B5,SLC19A3,SLC25A1,SLC25A5,SLC31A1,SLC38A1,SLC39A6,SLC5A3,SLIRP,SNRPA,SNRPD2,SNX17,SOX9,SPP1,SREBF2,SRP19,SRPRA,SRPRB,SSBP1,SSU72,STAM,STARD7,STAT1,STIM1,STOML2,STT3A,SUPV3L1,TAF6,TAPBPL,TARS,TCF7,TENM4,TFPT,TMBIM6,TMEM123,TMEM176A,TMEM176B,TMEM33,TMEM53,TMX2,TP53RK,TRAPPC6A,TRIM55,TRMT112,TRUB2,TSN,TXNDC12,TXNL1,TXNRD1,UBE2D3,UBQLN1,UCHL1,UCP2,UROS,USMG5,USP46,USP5,UTP18,VDAC1,XPNPEP2	 	
P2	 	LONP1	4.170	peptidase	 	-1.455	 	-0.206	-0.956	1.05E-12	ANXA2,ATP5D,ATP5J,C1QBP,HIST1H2BC,HSPA9,HSPB1,MDH2,MT-ATP6,MT-ATP8,MT-CO1,MT-CO2,MT-CYB,MT-ND4,MT-ND4L,MT-ND5,MT-ND6,PFN1,PGAM1,S100A11,TPM3,VDAC1	 	
P2	 	actinonin	 	chemical reagent	Activated	3.464	bias	-0.721	 	1.76E-12	MT-ATP6,MT-CO1,MT-CO2,MT-CO3,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND4,MT-ND4L,MT-ND5,MT-ND6	 	
P2	 	NR3C1	-1.151	ligand-dependent nuclear receptor	 	0.105	 	0.122	-0.524	2.08E-12	ACTN1,ADCK3,ALOX5AP,ANXA1,APOE,APP,ATP6AP1,BARD1,BCL2L14,BCOR,BIN1,CAPN2,CBX4,CD83,CIDEA,CKAP2,COMT,CPEB4,CRYAB,CSRNP1,CSRNP2,CXCL10,CYP3A5,CYR61,DAD1,DAPK2,DEAF1,DEGS1,DGAT2,DNASE1L3,DYNLL1,EDN1,EGR1,ELMO2,EPB41L4B,ERN1,FAM89B,FCER1G,FKBP4,FKBP5,FOS,GADD45B,GLIPR1,GLUL,GSTP1,GULP1,HCAR2,INSR,IP6K3,ISG15,ITGB2,JUN,KRT14,KRT5,LEP,LMO4,MAPK9,MKNK2,MTCH2,MYOC,NHLH1,NLRC4,NSMAF,PDCL3,PDGFA,PEA15,PER1,PHLDA2,PIK3R1,PIK3R3,PIM3,PLIN2,PPP2R1B,PRKACB,PSMA6,RASD1,RRAGC,RTN4,SEMA3C,SGPL1,SH3GLB1,SIAH2,SLC2A5,SLC38A1,SLC7A6,SPP1,STK39,STON1,THBS1,TNFRSF10B,TNFRSF12A,TP53,TPST2,TRAF3,TRIB3,TXN,UBE2K,VCAM1,YWHAG,YWHAH	CEBPA,CREB1,CTNNB1,HTT,JUN,L-glutamic acid,MYC,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,SP1,STAT1,TP53,TP63,TP73,dexamethasone,glucocorticoid	
P2	 	valproic acid	 	chemical drug	 	-1.291	 	0.014	-1.396	6.90E-12	AACS,ADCY1,ADRM1,AGPAT1,AKR1B1,AKR1C3,AMFR,ATF4,ATP5I,CARM1,CCND2,CCR1,CD151,CD209,CD83,CRAT,CTPS1,CTSB,CYP4A11,CYR61,DDIT3,DNAJB11,DPM2,EDEM1,EDN1,ERN1,FAS,GADD45B,GLUL,HIF1A,HMGCS1,HMOX1,HSPA5,JUN,KIT,LAGE3,LEP,MAPK10,MRPS2,MSMO1,MVD,NCAM1,NME1,NPC2,PDIA6,PLTP,POMP,PSMA3,PSMA4,PSMA6,PSMB10,PSMB2,PSMB4,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD7,PSMD8,PSME1,PTX3,SCD,SEL1L,SEMA3C,SIAH2,SLC1A2,SPP1,THBS1,THRSP,THSD4,TNS1,TOP2A,TRAF3,YWHAH	CREBBP,ERK1/2,ESR1,ESR2,FOS,FOXO3,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SP1,STAT1,TP53,TP73,beta-estradiol,cisplatin,corticosterone,valproic acid	
P2	 	NFKBIA	-1.795	transcription regulator	 	0.425	 	0.194	-1.066	3.86E-11	ACKR3,ADAMTS5,ATP5J2,BCKDK,BRF2,BTG2,CCND2,CCR1,COL5A2,CRYAB,CTNNA1,CTSB,CXCL10,DDIT3,DUSP6,ERAP2,FAS,FCGRT,FGF2,FOS,GADD45B,GAS5,GM2A,GRN,HIF1A,HLA-A,HMGA1,HMOX1,HOXA10,HOXB5,HSPA5,HSPA8,IL1RN,IRAK1,ISG15,ITGAV,JUN,LITAF,MPDU1,MSC,MT-CO3,MT-CYB,NAGLU,NINJ1,NR4A1,PARK7,PDGFA,PEA15,PIK3R1,PLD3,PTX3,RAC1,RPS2,RPSA,S100A8,SDC4,SEMA3C,SERPINE2,SFRP1,SLC12A2,SLC1A2,SOCS3,SOD1,SOX9,TGFB2,TIMP1,TMEM176B,TNFRSF10B,TOLLIP,TP53,UBA1,VCAM1	AHR,CEBPA,CHUK,CREBBP,CTNNB1,E2F1,EP300,IKBKB,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	UCP1	-2.982	transporter	Activated	4.447	 	0.216	3.187	3.88E-11	AARS,ALAS1,ARHGEF2,ASNS,ATF4,ATF5,BZW2,CEBPG,CHCHD10,CLCN3,DDIT3,ERN1,G6PD,GARS,GDF15,GHITM,GOT1,LEP,LRRC8D,MTHFD1L,NUPR1,ODC1,OTUB2,PCK2,PGD,PSAT1,SHMT2,SLC3A2,SRM,SYNM,TBC1D31,TENM4,TRIB3,UCP2,XPOT	CEBPB,JUN,NFkB (complex),RELA,STAT1,UCP1,cyclic AMP	
P2	 	hydrogen peroxide	 	chemical - endogenous mammalian	Activated	3.860	bias	0.449	0.371	9.12E-11	ADAM17,ADIPOQ,AKR1C1/AKR1C2,ANXA2,APP,ATP6V1A,BTG2,CCND3,CD63,CD68,CEBPG,CRYAB,CTSB,CTSD,CTSS,CYCS,DDAH2,DDIT3,DUSP10,DUSP4,EDN1,EEF1B2,EGR1,ENG,FAS,FGF2,FOS,FTH1,GADD45B,GDF15,HIF1A,HLA-DRA,HMOX1,HRAS,HSPA5,ISCU,JUN,KIT,KLF4,MIF,MSMO1,MSR1,MT-CO1,MT-ND6,NFE2L2,NR4A1,NUPR1,ODC1,OSGIN1,PFDN5,PLPP1,PPP1CA,PSMC4,PTX3,RAC1,RAN,RPL31,RPL7A,RTN3,SELENOH,SLC7A11,SOD1,SPP1,SREBF2,TNFRSF10B,TP53,TRIB3,TUBB2A,TXN,UCP2,UNG,VCAM1	AHR,Ap1,CREBBP,FOXO1,HIF1A,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,TNF,hydrogen peroxide,reactive oxygen species	
P2	 	SYVN1	1.771	transporter	Activated	4.584	bias	0.678	 	1.12E-10	ABCC3,ACP2,ACSL3,AES,APLP2,APP,ATP6AP1,BCAT1,CALM1 (includes others),CD151,CTPS1,DAB2,EMC7,ERN1,GANAB,HLA-A,HSPB1,ITGAV,LDHB,LMBRD2,NFE2L2,PFN1,PTPRJ,RAB10,RPL18,RPN2,SKIV2L,SLC1A5,SLC35B2,SLC3A2,SLC7A2,SLC7A5,TARS,USP5	 	
P2	 	TSC2	1.377	other	Inhibited	-2.726	bias	-0.323	-1.145	1.21E-10	ANXA1,ANXA2,ATF4,CCND2,CCND3,CRYAB,CST6,CXCL10,DDIT3,EGR1,FAM129A,FOS,HIF1A,HMOX1,HSPA5,HSPB1,METRN,NTRK3,PRELP,S100A11,SCD,SLC14A1,STAT1,THRSP,TMEM176A,TMEM176B,UCP2,VAMP8	AKT1,Ap1,CREBBP,ERK1/2,FOS,FOXO1,Gsk3,IRF8,JUN,MYC,NFE2L2,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TP53,TSC2	
P2	 	HIF1A	2.015	transcription regulator	Activated	2.877	bias	0.518	 	1.38E-10	ADAM17,ADIPOQ,ALDOA,APOE,ASNS,ATG9A,ATP5J,BHLHE41,CARS,CLDN1,CTPS1,CTSD,CYR61,EDN1,EIF5A,ENG,ENO1,FAM162A,FHL1,FOS,GADD45B,GAPDH,GBE1,HIF1A,HIST1H1C,HIST1H2AC,HIST1H2BK,HIST2H2AC,HMOX1,HSPA4,HSPA5,HSPB1,IL17RA,ITGAV,ITGB2,JUN,KRT14,LEP,METTL23,MIF,MT-CO3,MT-ND1,NR4A1,NRN1,P4HA2,PDGFA,PFKFB3,PFKL,PKM,POLRMT,PPIA,RET,SDC4,SESN2,SFRP1,SLC40A1,SOCS3,SOX9,SRD5A1,SSBP1,STC2,TGFB2,TP53,TP53RK	AHR,ARNT,CREBBP,EP300,EPAS1,ESR1,FOXO1,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),PPARG,SP1,TP53,TP63,TP73,VHL,estrogen receptor	
P2	 	IL1B	-2.672	cytokine	Activated	2.348	bias	0.323	-0.745	1.40E-10	ABCC3,ADAMTS5,AGER,AIF1,AKR1B1,ALPL,ANXA1,APOB,APOE,APP,ASS1,ATF4,ATF5,BAMBI,BTG2,CCL28,CCR1,CD14,CD4,CD74,CD83,CEBPG,CRYAB,CSRNP1,CTSB,CTSS,CXCL10,CXCL9,CYBB,CYP3A5,DAB2,DDIT3,EDN1,EGR1,ENG,F13A1,FAM129A,FAS,FGF2,FGFR2,FKBP5,FOS,FOSB,G0S2,G6PD,GADD45B,GBP1,GDF15,GM2A,GRN,GYS1,HEXA,HIF1A,HLA-A,HLA-DRA,HMGA1,HMOX1,HSPB1,IGFBP4,IL10RA,IL1RN,INSR,IRAK1,ISG15,ITGAV,JUN,LCP1,LEP,LGALS9,MAPT,MIF,MT-CO2,NFE2L2,NQO1,NR1D1,NR4A1,NR4A2,ODC1,PCSK6,PGAM1,PI3,PIM3,PLA2G2A,PLAA,PLD3,PSMB10,PTGFR,PTX3,RAN,RNASE1,RPSA,S100A8,SAA1,SAA2,SCNN1B,SCUBE1,SDC4,SLC14A1,SLC1A2,SLC1A3,SOCS3,SOX9,SPP1,STAT1,STMN2,THBS1,THRSP,TIMP1,TLR8,TMEM176B,TREM2,TYMP,VCAM1,XYLT1	AHR,CEBPB,CREBBP,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	CEBPA	2.050	transcription regulator	Activated	2.727	 	0.240	0.946	3.20E-10	ABCA3,ADIPOQ,AKR1B1,AKR1C1/AKR1C2,AKR1C3,ALOX5AP,ANXA1,APOB,ASNS,ASS1,ATF4,BIN1,BTG2,C3AR1,CCND2,CCR1,CD14,CKAP4,CREG1,CSF1R,CTNNA1,CYCS,CYP3A5,DGAT2,EDF1,EPHX1,FHL1,FOS,G0S2,GAPDH,GBP1,GLIPR1,GSTP1,HMGA1,HMOX1,HSPA5,IGFBP4,IL1RN,INSR,ISG15,JUN,KRT14,LEP,LHCGR,LITAF,MAPKAPK2,MMRN1,MT-CO1,NR4A2,NR5A2,PCSK6,PGD,PLIN1,PLIN2,PLXND1,PTGFR,PTPRC,PTX3,S100A8,SAA1,SCD,SOCS3,SOD1,SPP1,TGFB2,THBS1,TUBB2A,UBE2I	Ap1,CEBPA,E2F1,ESR1,FOS,FOXO1,GATA1,IRF8,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RETN,RXRA,SMARCA4,SP1,SP3,SPI1,STAT1,TP53	
P2	 	cisplatin	 	chemical drug	Activated	3.784	 	0.211	2.008	3.86E-10	ABCC3,ADRM1,AKR1C1/AKR1C2,ANXA1,ANXA2,ANXA5,APITD1/APITD1-CORT,ASNS,ATF4,ATP6V0C,BHLHE41,BTG2,CAPN2,CAPN6,CCR1,CD14,CD53,CDC14B,CTSB,CXCL10,CXCL14,CXCL9,DDIT3,DMXL2,DUSP6,EDN1,EFEMP2,EGR1,FADS3,FAS,FCGR2A,FOS,G6PD,GAS5,GDF15,GSTP1,HIF1A,HK1,HMGCS1,HMOX1,HSPA5,IL10RA,ITGA7,JUN,KRT10,LDHB,LMO4,LYZ,MAPK9,MBD4,MNT,NCAM1,NEO1,NQO1,ODC1,PEBP1,PFKL,PHLDA3,PLEKHM1,PPIA,PSMB10,RAC1,RGL1,RHOBTB2,RPS16,RPS21,RPS27L,RPS5,RRM2B,S100A11,SESN2,SLC31A1,SLC39A3,SLC7A6,SMPD1,SOCS3,SOD1,SPP1,THBS1,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TNFRSF12A,TOP2A,TP53,TRPM6,TUBB,TYMP,UBE2A,UCP2,VCAM1	AHR,Ap1,CREBBP,EGR1,ERK,ERK1/2,FOS,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,cisplatin	
P2	 	pirinixic acid	 	chemical toxicant	Activated	3.524	bias	0.447	0.324	3.92E-10	ABCC1,ABCC3,ACOT4,AKR1C3,ALAS1,ALDH3A2,ANXA2,ANXA7,APOE,ASNS,CCND3,CD63,CFH,CIDEA,CTSB,CYP3A5,CYP4A11,DAD1,DYNLL1,FAS,FCER1G,FKBP1A,G0S2,G6PD,GADD45B,GAPDH,GBE1,GLUL,GOT1,HADHB,HIF1A,HIST1H1C,HLA-DQA1,HMGCS1,HMOX1,HOXA7,HSPB1,IL1RN,KPNA1,LDHB,LEP,NPC2,NR1D1,PCK2,PFKL,PIK3R3,PLA2G2A,PLIN2,PLIN5,PLTP,POR,PSMA3,PSMA4,PSMB4,PSMB6,PSMB7,PSMD14,PSME1,PTPRC,RTN4,SAA1,SCD,TALDO1,TBCA,TP53,TSPO,TXN,UBE2K,UCP2,VCAM1	ATF6,CEBPA,FOXO1,IL6,JUN,NFKB1,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT1,THRB,oleic acid,pirinixic acid	
P2	 	gentamicin	 	chemical drug	Activated	3.392	 	0.177	2.184	8.74E-10	ACSL3,ALCAM,ALPL,ATIC,BTG2,BTG3,CPEB1,CSRP2,CTSD,CXCL10,DDIT3,DMD,EGR1,EIF3B,EIF3D,FMO1,GAS5,GDF15,GJB2,GNL3,GUK1,HIST1H4H,HMOX1,HSPA5,HSPB1,HYOU1,JUN,LITAF,MAF,MYBBP1A,NME1,NR1D1,PLIN2,PSAT1,RPS27L,S100A1,SPP1,SQSTM1,TANGO2,TARS,TIMP1,TP53,TUBB,UBQLN1,VAT1,VCAM1,YWHAH	NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,Sod,gentamicin	
P2	 	lactacystin	 	chemical - protease inhibitor	Activated	3.013	bias	0.284	1.310	1.77E-09	AKR1B1,AKR1C1/AKR1C2,APOB,APP,ARHGDIB,ASNS,CCND2,CCND3,CCT2,CFL1,CRYAB,CTSD,DDIT3,EIF5A,FAS,FTL,GSTP1,HIF1A,HLA-A,HMOX1,HSPA5,HSPB1,HSPB8,MAP1B,NFE2L2,NR4A1,P4HA2,PEA15,PEBP1,PFN1,PPIA,RAC1,RPLP0,SLC3A2,SQSTM1,SREBF2,TP53,TUBB2A,TXN,TXNRD1	AKT1,APP,Ap1,EGR1,FOS,FOXO1,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,lactacystin	
P2	 	JUN	-3.314	transcription regulator	Activated	2.872	bias	0.359	0.724	1.86E-09	ALAS1,ANXA1,ANXA2,APOE,APP,ASNS,C3AR1,CA3,CAPN2,CAPNS1,CCND2,CCND3,CD14,CD68,COMT,CSF1R,CSTA,CXCL10,CXCL16,CYCS,CYGB,EDN1,FAS,FGF2,FLNC,FOLR2,FOS,FTH1,GOT1,GSTP1,HLA-G,HMGA1,HMOX1,IGFBP4,ITGAV,JUN,LAMP2,LHCGR,MAT2A,MBP,MCF2L,MSR1,MVD,NCAM1,NQO1,NR5A2,PEA15,PTX3,SAA1,SCD,SLC19A1,SLC7A1,SNCG,SOCS3,SPP1,SRP19,STAT1,STIM1,THBS1,TIMP1,TP53,TXN,VCAM1,XPO5,XYLT1,YWHAG	Ap1,CEBPA,CREBBP,EGR1,ELK1,EP300,ESR1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF,TP53	
P2	 	ESR1	-1.781	ligand-dependent nuclear receptor	 	0.156	 	0.100	-0.850	2.06E-09	AASS,ABCA3,ABCC3,ACKR3,ADAM17,ADCY1,ADORA1,AES,AK1,ALCAM,ANLN,ANO2,AP2S1,APOE,ARHGEF2,ARPC5L,ASS1,ATF5,ATP2B1,ATP6V1A,BCAT1,BIN1,C1QTNF5,CAPN2,CARM1,CCND3,CCNI,CCPG1,CD83,CEBPG,CFL2,CHST2,CLCN3,CLDN1,COL16A1,COL5A2,COL8A1,COMT,CPM,CSNK1A1,CTSB,CTSD,CTSS,DAB2,DMTN,DNAJC1,DUSP10,DUSP4,EDN1,EGR1,EIF5A,ENAH,ENO1,ESR2,FAS,FGFR2,FHL1,FIS1,FKBP4,FLNA,FOS,FOSB,G6PD,GADD45B,GJB2,GLB1,GM2A,GNA12,GNB1,GULP1,HAX1,HIF1A,HIST1H4C,HLA-G,HPS1,HSPA13,HSPA2,HSPH1,HTRA1,IGFBP4,INSR,IPO7,JUN,KCNMA1,KCNQ4,KCTD13,KIF3B,KIF5B,LANCL1,LAPTM5,LEP,LHCGR,MAP1B,MAPT,MCF2L,MINOS1,MKI67,MPC1,NLGN1,NME1,NPR3,NQO1,NR1D1,OTUB2,PHB2,PLCE1,PLIN2,POR,PPP1R9B,PRKACB,PSAT1,PTX3,RAB5C,RAMP3,RHEB,SCAMP3,SCNN1B,SEMA3C,SIAH2,SIPA1L1,SLC1A4,SLC3A2,SLC7A1,SLC7A11,SLC7A2,SLC7A5,SLC9A3R1,SMPD1,SOX9,SPP1,SPRY4,SQSTM1,SRM,STAT1,STC2,TESK1,TGFB2,TGFBR1,THBS4,TMEM2,TNPO1,TP53,TRIB3,TRIM16,TSPO,UQCR10,VPS11,WARS,YARS,YIPF2,ZBTB7B	Ap1,CTNNB1,ESR1,ESR2,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),PPARG,RB1,RELA,SP1,TP53,beta-estradiol,estrogen,estrogen receptor,fulvestrant,tamoxifen	
P2	 	bromobenzene	 	chemical toxicant	 	1.333	 	0.016	1.270	2.45E-09	ABCC1,ABCC3,DDIT3,FMO1,FOS,GAPDH,GOT1,GSTP1,HMGCS1,HMOX1,HSPA13,HSPA5,HSPB1,JUN,LONP1,MSMO1,NQO1,NUPR1,POR,RPL28,RPL35,TIMP1	 	
P2	 	ESR2	-3.103	ligand-dependent nuclear receptor	 	-0.155	 	0.092	-0.696	3.05E-09	ADAMTS5,ADORA1,AES,ANO2,APOE,ARRDC4,ATF5,ATP2B1,BCAT1,BIN1,CADM3,CAPN2,CES1,CHST15,CHST2,CLDN1,COL16A1,CPM,CTSD,DMTN,DNAJC1,DUSP10,EDN1,EGR1,ESR2,FHL1,FOS,GLB1,GM2A,GSTP1,HSPA2,IGFBP4,IP6K3,KAZALD1,KCNJ3,KCNK15,KLF4,KRT14,KRT6B,LAPTM5,LEP,LHCGR,LIMCH1,ME2,MKI67,MPC1,OTUB2,PDGFA,PLIN2,PSAT1,PTGFR,PTX3,S100A7,SCUBE1,SFRP4,SLC9A3R1,SOCS3,SPP1,STON1,TENM4,TESK1,THBS4,THRSP,TIMP1,TMEM2,TSPO	AHR,APOE,ARNT,CREB1,CTNNB1,ESR1,ESR2,HIF1A,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,beta-estradiol,estrogen receptor	
P2	 	PD98059	 	chemical - kinase inhibitor	Inhibited	-3.533	bias	-0.447	0.304	3.29E-09	ADIPOQ,ALDOA,ANXA1,ATF4,CCND2,CCR1,CD14,CD4,CD74,CD83,CDC42EP1,CTSB,CXCL10,CYCS,DDIT3,DSG1,DUSP4,DUSP6,EDN1,EGR1,ENG,ENO1,FGF2,FKBP5,FOS,FOSB,FTH1,GFPT1,GRN,HADHB,HIF1A,HMOX1,HNRNPAB,HPCAL1,HSPA5,HYOU1,IL1RN,INSR,ITGAV,ITGB2,JUN,LAMP1,LAMP2,LEP,MAPKAPK2,MAT2A,MCF2L,MIF,MKI67,MSR1,NINJ1,NQO1,NR4A1,PCSK6,PDGFA,PER1,PFKFB1,PHLDA2,PIK3R1,RAN,RPS2,S100A8,SIGMAR1,SIRPA,SLC3A2,SOCS3,SOD1,SPP1,ST6GALNAC2,THBS1,TIMP1,TNFRSF10B,TOP2A,TP53,TUBB2A,TXN,TYMP,VAPA,VCAM1	CEBPA,CREBBP,ELK1,ERK1/2,FOS,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RAF1,RELA,SP1,STAT1,TNF	
P2	 	tetraethylammonium	 	chemical drug	 	-1.058	 	-0.166	-0.395	4.58E-09	ARHGDIA,CBX3,FTH1,HSPA8,HSPA9,HSPB1,LYPLA1,NDUFS8,PARK7,PSMA6,PSMB4,RPLP0,SARS,SSR4,TBCB,UTP15	 	
P2	 	CD3	 	complex	Inhibited	-3.334	bias	-0.486	0.521	4.66E-09	AARS,AHCYL1,ALAS1,ANXA1,AP1B1,ARHGDIB,ATF4,BAMBI,CALM1 (includes others),CCND2,CCND3,CCR1,CD2,CD28,CD4,CD53,CD74,CD83,CLIP1,CXCL10,CYCS,DAD1,FAS,FBL,FCER1G,FKBP1A,FKBP2,FOS,FTL,FYB,G6PD,GAPDH,GBP1,GYS1,HAX1,HIF1A,HINT1,HIST1H2AC,HLA-DQB1,HS2ST1,HSPA5,HSPA8,IL2RG,JUN,KRT14,LAMP1,LCP1,LONP1,LYPLA1,MAF,MDH2,MMRN1,MSR1,MT-CO1,NFE2L2,NME1,NR4A1,OAZ1,ODC1,PFN1,PGAM1,PHB2,PLEK,PLIN2,POLR2K,PSAP,PSMA6,PTPRC,PTPRJ,RPL30,RPS3A,S100A11,SDF2,SEC61B,SLC25A5,SLC5A3,SNRPC,SOCS3,SRPRB,STAT1,STIM1,TCEA1,TCF7,THBS1,TOP2A,TXNRD1,UQCR11,YARS	Ap1,BCL6,CD3,IL10,IL2,IRF8,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TCR	
P2	 	FOS	-4.894	transcription regulator	Activated	2.763	 	0.201	1.503	5.10E-09	ABCC1,ACTG1,ADAM12,AKR1C3,ALAS1,AP3D1,APLP2,ARF1,ARPC5,C3AR1,CAMK2D,CAPN2,CD14,CD68,CLIP1,COL16A1,CSTA,CTSB,CXCL16,CYCS,DAP,DAPK2,EDN1,EGR1,ENAH,ENO1,FARS2,FGF2,FOLR2,FOS,FOSB,FTH1,GAS5,GBA,GJB6,GM2A,GSTP1,HMOX1,HSPA5,HSPB8,JUN,KIF2A,KIF5B,LAMP2,MAP4K4,MMRN1,NFE2L2,NQO1,NR5A2,ODC1,PCDH19,PFN1,PKN1,PXK,RFNG,RNH1,RPLP0,RPS24,S100A8,SCD,SERPINE2,SFRP4,SIRPA,SLC19A1,SNCG,SOCS3,SPP1,STIM1,TBCA,TCEA1,TIMP1,TP53,TPP1,TUBB,TXN,VCAM1,XYLT1	AHR,Ap1,CREB1,CREBBP,EP300,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1	
P2	 	tosedostat	 	chemical drug	Activated	3.712	bias	0.673	 	5.55E-09	ASNS,ASS1,ATF5,CARS,CHAC1,DDIT3,MARS,PSAT1,SARS,SESN2,SLC7A11,STC2,TRIB3,WARS	 	
P2	 	benzyloxycarbonyl-Leu-Leu-Leu aldehyde	 	chemical - protease inhibitor	Activated	2.661	bias	0.338	0.390	6.36E-09	AKR1B1,AKR1C1/AKR1C2,APP,ARHGDIB,ATF4,CCND2,CCND3,CCT2,CFL1,CRYAB,CTSB,CXCL10,DDIT3,DMD,EIF5A,FAS,FGF2,FOS,G0S2,GSTP1,HIF1A,HMOX1,HSF4,HSPA4,HSPA5,HSPA8,HSPA9,HSPB1,JUN,MAT2A,NFE2L2,NQO1,PEBP1,PFN1,PPIA,PSMA3,PSMB2,PSMC4,PSMD2,PTGFR,RAC1,RHOBTB2,RPLP0,SOD1,SQSTM1,STAT1,TIMP1,TNFRSF10B,TP53,TXN,VCAM1	Ap1,EGR1,FOS,HRAS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,TP53,benzyloxycarbonyl-Leu-Leu-Leu aldehyde	
P2	 	forskolin	 	chemical toxicant	 	1.977	bias	0.348	-0.931	7.95E-09	ACTN1,ADIPOQ,AIP,ALDOA,ALPL,APP,ATP6V0B,ATP6V0C,ATP6V1A,ATP6V1B2,BTG2,CALM1 (includes others),CCDC85B,CCND2,CCND3,CD14,CD4,CD68,CDK16,COL15A1,CRISPLD2,CTBP1,CYP3A5,DAB2,DDIT3,EDN1,EGR1,EIF5A,EMD,ESR2,FAS,FCER1A,FGFR2,FKBP5,FLNC,FOS,FOSB,GAB2,GADD45B,GBP1,GRN,GSTP1,HIF1A,HLA-DQA1,HLA-DQB1,HLA-DRA,HMOX1,JUN,KLF4,LAMP1,LEP,LHCGR,LITAF,MAP4K4,MAT2A,MIF,MSMO1,NPC2,NPY1R,NR4A1,NR4A2,ODC1,P4HA2,PEG10,PER1,PIM3,PLPP1,RAB5C,RAB7A,RORB,RPL37A,RPL38,RPS10,S100A8,SERINC2,SLC1A2,SLC2A5,SLC7A11,SPP1,SSBP1,STARD7,STAT1,THBS1,THRSP,TIMP1,TMBIM6,TP53,TPO,UCP2	CEBPA,CREB1,CREBBP,CREM,CTNNB1,FOS,FSH,IL1B,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,forskolin	
P2	 	MT-TM	1.170	other	 	 	 	 	 	8.99E-09	MT-CO1,MT-CO2,MT-CYB,MT-ND1,MT-TE,MT-TL1,MT-TP,MT-TQ,MT-TT,MT-TY	 	
P2	 	interferon beta-1a	 	biologic drug	 	 	 	 	 	1.07E-08	ANAPC11,ATP5I,ATP5L,CD4,CSF1R,ENO1,FCER1G,FCGRT,FKBP1A,FYB,GADD45B,GSTP1,IL1RN,NDUFA1,NDUFA2,NDUFB2,PFDN5,PGAM1,PPIA,PSME1,RAN,RPL18,RPL19,RPL26,RPS19,SLC25A6,STAT1,TBCB,TTC1	 	
P2	 	sodium arsenite	 	chemical drug	 	1.798	 	0.188	1.043	1.24E-08	ABCB6,ABCC1,DDIT3,EGR1,FOS,FTH1,GADD45B,GCLM,GSS,HIF1A,HMOX1,HSPA4,JUN,LITAF,MAT2A,SOCS3,TNFRSF10B,TP53	Ap1,EGR1,FOS,IKBKB,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,sodium arsenite	
P2	 	methylprednisolone	 	chemical drug	Activated	2.176	 	0.145	1.060	1.58E-08	ADAM17,AKR1C3,ALAS1,ALDH3A2,ANXA1,ANXA2,ASNS,ASS1,ATIC,C1QB,C1QBP,CD74,CIDEA,COMT,CREG1,CTSS,CYBB,CYCS,DAB2,DMD,DNPH1,DSG1,DUSP6,DYNLL1,EIF3B,EPHX1,FARSA,FCGR2A,FKBP4,FOS,G0S2,GCLM,GNL3,GOT1,GPC1,GSTP1,HAGH,HMBS,HMOX1,HSPH1,IGSF6,IL1RN,ITGA7,JUN,KRT10,MAPK9,ME1,MGAT1,MYBBP1A,NFE2L2,NME1,NUPR1,ODC1,PGAM1,PHLDA2,PIM3,PLAA,PLIN2,POR,PSAT1,PTER,PTPRC,RAMP3,SDC4,SEPHS2,SIRPA,SLC19A1,SLC40A1,SLC7A2,STAT1,TMEM53,TMSB10/TMSB4X,TOP2A,TP53,TUBA1C,VCAM1	Ap1,CEBPA,CEBPB,FOXO1,IFNG,IGF1,IL6,IRF8,JUN,NFKB1,NFkB (complex),NR3C1,RELA,SP1,STAT1,TP53,methylprednisolone	
P2	 	MGEA5	-1.205	enzyme	 	-0.927	 	-0.068	-0.416	2.04E-08	ACTG1,ADGRG2,ADRM1,AIFM2,ALOX5AP,APOE,ARPC4,ASS1,ATP5I,ATP5L,BCOR,C1QA,C1QB,C3AR1,CCR1,CD14,CD151,CD53,CD68,CIAPIN1,CLDN1,CSF1R,CXCL16,DAB2,EPHB3,FAS,FLNA,G6PD,GAA,GALNT4,GLUL,HMGCS1,IGFBP4,JUN,MSMO1,NDUFA11,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFA9,NDUFC2,NDUFS4,PIK3R1,PLCE1,PLIN2,RAP2A,S100A2,SERPINE2,SOCS3,SORBS1,SOX9,SREBF2,STAT1,THBS1,TIMP1,TNFRSF12A,TP53	AHR,Alpha catenin,CEBPA,CHUK,CREB1,CREBBP,CTNNB1,FOXO1,Insulin,JUN,MGEA5,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,TCF,TP53	
P2	 	cycloheximide	 	chemical reagent	Inhibited	-3.035	 	-0.095	-2.376	2.06E-08	ADCY1,ALDOA,APOB,APP,ASS1,BTG2,CCND3,CCR1,CD4,CXCL10,CYP3A5,CYP4A11,CYR61,DTYMK,EDN1,EEF1D,EGR1,ESR2,FAS,FGF2,FOS,FOSB,GADD45B,GBP1,GCLM,GOT1,HEXA,HMOX1,IGFBP4,IL1RN,JUN,KCND3,KDM6B,LARP6,LEP,LONP1,MT-CO1,MT-CO2,MYOC,NFE2L2,NQO1,NR4A1,PDGFA,PFKFB3,PLA2G2A,PTX3,RHOBTB2,S100A8,SCD,SOCS3,SPP1,TGFBR1,THBS1,TIMP1,TNFRSF10B,TP53,VCAM1	Ap1,CEBPA,EGR1,FOS,IL1B,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,cycloheximide	
P2	 	KRAS	1.014	enzyme	Activated	3.076	 	-0.003	3.094	2.07E-08	ALDOA,AOX1,APLP2,CCND3,CD74,CRYAB,CXCL10,DDIT3,DUSP4,DUSP6,EIF5A,ETV5,FAS,FOS,FTH1,G6PD,GBA,GLUL,GRN,HADHB,HEXA,HIF1A,HSPA5,HSPB1,HYOU1,ISG15,JUN,LAMP1,LAMP2,MT-CO1,MT-ND4,NCAM1,NFE2L2,NME2,NQO1,NR5A2,NRN1,PPP1CA,RAB7A,RNH1,RPSA,SDC4,SERPINE2,SIRPA,SLC3A2,SOX9,SQSTM1,STAT1,TCEA1,THBS1,TNFRSF10B,TOP2A,TP53,UBE2I,VAPA,VCP	Ap1,EGFR,FOXO1,HIF1A,HTT,JUN,KRAS,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TP53	
P2	 	HTT	1.361	transcription regulator	Activated	2.512	 	0.149	1.900	2.64E-08	ADAMTS5,ALDOA,APP,ATP5G1,ATP5J2,BCAP31,BTG3,CBR1,CD74,CLDN1,COL16A1,CRYAB,CSF1R,CTSD,CYCS,DDIT3,DPM2,DUSP6,EGR1,EPB41L3,FGF1,FHL1,FKBP4,FOS,GAPDH,GLO1,GLUL,GPC1,GSS,HIF1A,HMGA1,HMGCS1,HPCAL1,HRAS,HSPA5,HSPA8,HSPA9,JUN,KLF4,LDHB,MDH2,MFAP4,MOBP,MPEG1,MT-CO3,MT-CYB,NDUFA1,NDUFA11,NDUFA12,NDUFB2,NDUFB4,NDUFS3,NDUFS4,NFE2L2,NR4A1,NR4A2,P2RX7,PDLIM4,PEA15,PER1,PFN1,PLOD3,POR,PPP1R1B,PRELP,PRKACB,PSMB4,PSME1,RAB10,RPS29,SDHB,SFRP1,SIRPA,SLC12A2,SLC1A2,SLC1A3,SLC25A22,SLC40A1,SOD1,SPP1,SQSTM1,SRM,STXBP1,SYP,THRSP,TP53,TUBB,UCHL1,UQCR11,VAPA,VCAM1,YWHAG	APP,Ap1,BDNF,CEBPA,CEBPB,CREB1,EGR1,ELK1,FOS,FOXO1,HIF1A,HTT,Ins1,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),NR3C1,PPARG,STAT1,dopamine,estrogen receptor	
P2	 	DYSF	1.232	other	 	 	 	 	 	2.95E-08	ACTG1,ANXA1,ANXA2,C1QB,CD53,CD68,CD74,CD83,CHMP1A,CTSS,CXCL10,FTL,HLA-A,HLA-DQA1,HLA-DQB1,HSPB1,LCP1,LYZ,MPEG1,PSAP,TIMP1,TMEM123	 	
P2	 	cholesterol	 	chemical - endogenous mammalian	 	0.742	 	0.209	-0.464	3.38E-08	APOB,APOE,APP,ATF4,C1QC,CD14,CD68,CXCL10,CYP3A5,DDIT3,EPHX1,FGF2,GBA,HMGCS1,HSPA5,IL10RA,IL1RN,LAPTM5,LYZ,MAPT,ME1,MPEG1,MSMO1,NR4A1,NR4A2,PLTP,PMVK,PSAT1,S100A8,SAA1,SCD,SLC1A3,SLC7A5,SOCS3,SREBF2,THBS1,TIMP1,TMEM123,VCAM1	APOE,CEBPA,CREB1,CTNNB1,EGR1,FGF2,IL1B,IL6,JUN,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,cholesterol	
P2	 	OSM	-2.969	cytokine	Activated	2.202	 	0.238	0.223	3.38E-08	ABCC1,ABCC3,ACSL3,ADAM17,ADAMTS5,AHCYL1,AKR1C1/AKR1C2,AKR1C3,ANXA1,ANXA2,ARHGEF2,ASNS,BAMBI,CBX3,CCND2,CIZ1,CLIP1,COL8A1,COX7B,CPM,CST6,CXCL10,CYP3A5,DEGS1,FGF2,FOS,GBP1,GFPT1,GLUL,HIF1A,HLA-A,HMOX1,HSF4,HSPA2,HSPA5,IRAK1,JUN,KCNG1,KIF5B,LITAF,LSM4,MKNK2,MPDU1,MSC,NMT2,PDGFA,PFKFB3,PI3,QSOX1,RAP2A,S100A7,S100A8,SAA1,SBF1,SCNN1B,SEL1L,SEPT9,SKIV2L,SMPD1,SOCS3,STAT1,TECR,TIMP1,TMBIM6,TOP2A,TP53,TPO,TULP3,TYMP,UBE2G1,USP46,VCAM1,VPS11,ZNF330	CREBBP,ERK1/2,FOS,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),OSM,P38 MAPK,RELA,SP1,STAT1	
P2	 	beta-naphthoflavone	 	chemical toxicant	Activated	3.523	bias	0.324	2.381	4.26E-08	ABCC3,AKR1C1/AKR1C2,APOE,CBR1,CYP4A11,CYP4B1,CYR61,FOS,FTH1,GCLM,GSTP1,MAFG,ME1,NQO1,NR4A1,SAA1,SLCO2B1	AHR,Ap1,BACH1,EGR1,EP300,ESR1,FOS,JUN,Jnk,NFE2L2,NFkB (complex),RELA,SP1,TP53,benzo(a)pyrene,beta-naphthoflavone	
P2	 	PPARA	-1.048	ligand-dependent nuclear receptor	 	0.082	 	0.225	-1.459	5.19E-08	ADIPOQ,ALDH2,ALDH3A2,ANXA2,APOE,APP,ARHGDIA,ASNS,ASS1,BCKDK,C1QA,C1QB,C6,CD63,CFH,CIDEA,CYBB,CYP4A11,DYNLL1,EDN1,FOS,G0S2,G6PD,GLUL,GSTP1,H2AFZ,HADHB,HIF1A,HIST1H1C,HLA-DQA1,HMGCS1,HMOX1,IL1RN,MAT2A,ME2,MKI67,MSMO1,MT-CO2,MVD,NFE2L2,NR1D1,PLA2G2A,PLIN1,PLIN2,PLIN5,PLTP,PMVK,POR,RTN4,SAA1,SCD,SERINC2,SREBF2,SRM,STIM1,TALDO1,TOP2A,TPP1,TSPO,TXN,UCP2,VCAM1	ATF6,Ap1,CEBPA,CEBPB,FOXO1,JUN,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RXRA,SREBF1,THRB,fenofibrate,oleic acid,pirinixic acid	
P2	 	ERBB2	-1.078	kinase	 	1.233	bias	0.342	-0.966	5.24E-08	ADAM12,ADAM17,ADAMTS5,ALAS1,ANXA2,APLP2,ATF4,ATP6V1A,BARD1,BTG2,CCND2,CCND3,CES1,CHCHD10,CHST2,COL5A2,CSF1R,CTSB,CXCL10,CYP4B1,DAP,DDIT3,DERL1,DPT,DUSP6,EDN1,EGR1,ESR2,ETV5,FOS,GBE1,GLO1,GPAA1,GPC1,HADHB,HIF1A,HIST1H4C,HNRNPK,HSPB1,HSPB8,HTRA1,IGFBP4,JUN,KIFC3,KIT,KLF4,LAMP1,LAMP2,LITAF,MAP1B,MIF,MKI67,MKNK2,MYL9,NDUFAB1,NNMT,NPC2,NRBP1,P4HA2,PCK2,PDLIM4,PFKFB3,PHLDA2,PSMD8,PTPRK,RPL17,RPS10,SEC61A1,SFRP1,SIRPA,SORBS1,SRP19,ST3GAL6,TAX1BP3,TGFBR1,THBS1,THBS4,TNFRSF10B,TOP2A,TP53,TP53RK,UCK1,UQCR10,WNT5B,WSB2	EGFR,ERBB2,ERBB4,FOXO1,HTT,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP63,TP73,curcumin	
P2	 	GnRH analog	 	biologic drug	 	-1.482	 	-0.029	-1.277	5.85E-08	ABCC1,ACTN1,AGER,AHCYL1,AP3D1,ASNA1,ATP6V1E1,CAPNS1,CDK16,CNPY3,CST6,DVL1,DYNLL1,FAS,FCGRT,FGF2,FKBP1A,FOS,GABARAP,HADHB,HIF1A,HINT1,HSPA2,JUN,KRT10,MKI67,MXRA7,NARS,NME2,NR4A2,NTRK3,PHLDA2,PI4KA,PIK3R3,PLD3,PPIA,PSMA6,PSMB4,PSMB7,RAB5C,RAN,SDF2,SFRP1,SLC25A44,SLC7A11,SLC7A6,TCEA1,TMBIM6,TP53,UBE2D3,VAT1,VCP,WSB2	CREB1,CTNNB1,FOS,FSH,GnRH analog,JUN,Lh,NFkB (complex),STAT1	
P2	 	inosine	 	chemical - endogenous mammalian	Activated	4.061	bias	0.551	 	5.95E-08	AIF1,ALCAM,ANXA1,ANXA2,ANXA5,ARPC1B,C1QA,C1QB,C1QC,CD63,CD68,FTL,LCP1,NPC2,PPP1R14B,TIMP1,TSPO	 	
P2	 	Insulin	 	group	 	0.866	 	0.232	-0.633	7.16E-08	ADIPOQ,ALDOA,APOE,APP,CA3,CCND3,CIDEA,CYBB,DUSP4,EDN1,EGR1,FOS,FOSB,FTL,G6PD,GSTP1,HIF1A,HMOX1,HNRNPK,HSPA5,IGFBP4,INSR,JUN,KCNJ3,LEP,MAPT,MDH2,ME1,MT-ND1,MTCH2,NDUFA1,NR4A1,NR4A2,ODC1,OGT,PCCB,PIK3R1,PKM,PLIN1,RAC1,RPL32,RPS16,SCD,SLC25A5,SLC2A5,SLC38A3,SLC7A1,SORBS1,SRD5A1,SREBF2,THRSP,TPO,UCP2	AGT,ARNT,CEBPA,CEBPB,CTNNB1,D-glucose,FOXO1,HIF1A,IGF1,Insulin,JUN,LEP,MYC,NFKBIA,NFkB (complex),NR3C1,PPARG,RELA,SP1,STAT1,STAT5B,TP53,dihydrotestosterone	
P2	 	tunicamycin	 	chemical - endogenous non-mammalian	Activated	3.608	bias	0.396	1.336	8.13E-08	ADCYAP1R1,ASNS,ATF4,CCND3,CHAC1,DDIT3,DGAT2,DNAJB11,EDEM1,EGR1,GADD45B,HMOX1,HSPA5,HSPA9,KLF4,LONP1,MVD,NARS,PCK2,PDIA6,PLIN2,PRNP,SCD,SEC61A1,SEL1L,SESN2,SIGMAR1,SLC7A11,SRP19,SRPRA,TBCB,TMED3,TNFRSF10B,TP53,TPO,VCAM1,WARS	ATF6,Ap1,DDIT3,EGR1,EIF2AK3,ERN1,FOS,FOXO1,FOXO3,Jnk,NFE2L2,NFKBIA,NFkB (complex),RELA,STAT1,TP53,XBP1,tunicamycin	
P2	 	AKT1	1.185	kinase	Activated	2.788	bias	0.312	0.969	8.21E-08	ADIPOQ,AIP,AKR1C1/AKR1C2,ASS1,C1QC,CCND2,CCND3,CD4,CD74,CIDEA,COL8A1,CXCL10,EGR1,FAS,FGF2,FOS,FOSB,GCLM,GDF15,HIF1A,HMGCS1,HMOX1,LEP,MBP,ME1,MSMO1,MSR1,NFE2L2,NQO1,PIK3R1,PPP1R1B,RAMP3,SCD,SLC3A2,SPP1,SREBF2,TGFB2,THBS1,TIMP1,TP53,UNC5B,VCP	AHR,AKT1,CEBPB,ERK,IFNG,IRF8,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,TNF	
P2	 	thioacetamide	 	chemical toxicant	Activated	3.063	bias	0.609	 	8.64E-08	AACS,AKR1C3,ANXA1,ANXA2,ASNS,BARD1,CAPN6,CD14,CPA3,CSRP2,CTBP1,CYGB,EPHX1,FCER1A,FCGR2A,GAS5,GDE1,GOT1,HK1,HSPA4,ITGA7,JUN,MBD4,MS4A2,NFE2L2,NLGN1,NUPR1,ODC1,PCSK6,PKM,POR,PPT1,PRELP,PSMB10,S100A11,SCPEP1,SLC7A11,SPP1,STEAP3,TGFBR1,TIMP1,TMSB10/TMSB4X,TNFRSF12A	CEBPA,EGR1,JUN,NFkB (complex),SP1,TGFB1,thioacetamide	
P2	 	17-alpha-ethinylestradiol	 	chemical drug	 	0.640	 	0.227	-0.436	8.83E-08	AARS,ABCC3,APOB,APOE,ASNS,ATF4,BCAT1,C1QB,C1QC,CCR1,CD53,CD68,CD74,CSF1R,CTSS,CXCL10,EIF2S2,ESR2,FOS,IFI30,IL17RA,JUN,KRT14,NME1,ODC1,SLC25A5,SLC38A3,SLC40A1,SLC4A2,VCAM1	17-alpha-ethinylestradiol,CEBPA,CEBPB,IFNG,IL6,IRF8,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SMARCA4,SPI1,SREBF1,STAT1,cholesterol,lipopolysaccharide	
P2	 	PPARG	1.294	ligand-dependent nuclear receptor	 	0.251	 	0.233	-1.333	9.89E-08	ABCA3,ADIPOQ,APOE,APP,BIN1,CCPG1,CES1,CIDEA,CRAT,CTPS1,CXCL14,CYP4A11,CYP4B1,DGAT2,EDN1,EPHX1,FGF1,GAPDH,GDF15,GIPR,HADHB,HMOX1,HYOU1,INSR,JUN,KLF4,LEP,LHPP,ME1,MKI67,MKNK2,NFE2L2,NR1D1,NR4A1,ODC1,PCK2,PCLO,PEA15,PFKFB3,PLA2G2A,PLIN1,PLIN2,PLIN5,RGL1,RPSA,S100A8,SAA1,SCD,SLC9A1,SNCG,SOCS3,SOD1,SORBS1,SPP1,STIM1,TGFBR1,TP53,TRIB3,TUBB,UCK1,UCP2,VAMP8,VCAM1,XYLT1,YWHAG	ATF6,CEBPA,CREBBP,EGR1,JUN,LEP,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT1,STAT5B,oleic acid,rosiglitazone,troglitazone	
P2	 	HRAS	2.152	enzyme	Activated	2.078	 	0.244	0.638	1.02E-07	ACTG1,ANXA2,APP,ARF1,ASNS,ATP5J,BTBD11,BTG2,C1QC,CAPG,CAPN2,CCND2,CCND3,CHST11,COL5A2,CSRP2,CSTA,CTSB,CTSS,CXCL10,DDIT3,DUSP6,EGR1,EPHX1,ERP29,FAS,FGF2,FHL1,FLNA,FOS,FOSB,GJB2,GRN,HIF1A,HMOX1,HRAS,HSPA8,HSPB1,HTRA1,IFI30,IGFBP4,IGKC,ITGAV,JUN,LYZ,MSMO1,MTHFD1L,MYL12A,MYL9,NQO1,PDGFA,PDGFC,PFN1,PLTP,POLR2G,PRELID1,PRNP,RPL30,RPL37,RPLP1,RPS10,RTN4,SERPINE2,SIRPA,SOD1,SORBS1,SPP1,TGFB2,THBS1,TMSB10/TMSB4X,TNFRSF10B,TOP2A,TOX2,TP53,TPO,TYMP,WSB2	AKT1,Ap1,EGR1,ELK1,ESR1,FOS,FOXO1,HRAS,JUN,MAP3K1,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	arsenite	 	chemical toxicant	 	0.629	bias	0.285	-0.339	1.05E-07	ABCC1,ADAM12,ATF4,COL8A1,CXCL9,EGR1,FOS,GCLM,GPC1,GSTP1,HMOX1,HSPA9,HSPB1,INSR,JUN,MAFG,NFE2L2,NQO1,NR4A1,RNH1,SFRP4,SQSTM1,TGFB2,THBS1,TXNRD1	AKT1,Ap1,EGR1,ELK1,FOS,FOXO1,FOXO3,Jnk,MAP2K1/2,Mek,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,arsenite	
P2	 	ANGPT2	-1.192	growth factor	Activated	4.134	bias	0.527	 	1.10E-07	ABCC1,ADAM12,ARHGEF2,CD68,COMT,CRYAB,DDIT3,EDN1,EEF1B2,EFR3A,FAS,FKBP2,FKBP4,HIF1A,HMGCS1,HMOX1,HSPA2,HSPA4,HSPA5,KDM6B,KPNA2,LARP4,LEP,MAPK10,MIF,NME1,PDIA6,SOD1,SPTLC3,THBS1,TMEM41B,TNFRSF10B,TNFRSF12A,TP53,UBE2A,VCAM1	ANGPT2,Ap1,EGR1,FOS,HIF1A,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PI3K (family),RELA,SP1,STAT1,nitric oxide	
P2	 	nitrofurantoin	 	chemical drug	Activated	2.692	 	0.092	2.167	1.14E-07	ACTG1,ANXA2,ANXA5,APOE,ASNS,ASS1,BTG2,CAPN2,CAPN6,CES1,CTSB,CTSS,CXCL10,CYP4A11,DDIT3,FAS,GAS5,GSS,GSTP1,HMGCS1,HMOX1,HSPA5,NQO1,ODC1,RPS8,S100A11,SPP1,TIMP1,TNFRSF12A,TP53,TUBB,TXN,VCAM1	 	
P2	 	SOD1	1.777	enzyme	 	-1.330	bias	-0.499	-0.268	1.22E-07	APOE,ASS1,ATF4,AURKAIP1,C1QA,CD14,COMT,CRYAB,CSF1R,FOS,FTH1,GCLM,GSTP1,GUK1,HMOX1,HPCAL1,HSPA4,HSPA8,HSPB1,JUN,MT-CO1,MT-ND1,MT-ND4,NFE2L2,SH3BGRL3,SLC1A2,SLC40A1,SNCG,SOD1,SPP1,SQSTM1,STIP1,SYP,TNFRSF10B,TP53,VAPA,VCAM1	Ap1,FOS,HSF1,HSF2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SOD1,SP1,TNF,TP53,TP63,TP73,hydrogen peroxide,nitric oxide	
P2	 	PRL	-2.790	cytokine	Activated	2.875	bias	0.473	-0.125	1.30E-07	AKR1C3,ANXA2,ANXA5,APP,CAPN2,CCND3,CTSA,CTSB,CTSD,CTSS,CXCL10,CXCL9,DVL1,EGR1,ENO1,ESR2,FOS,GNA12,ISG15,JUN,KRT14,KRT5,LAMP3,LHCGR,MAFG,MARS,NUPR1,ODC1,PDLIM4,PIM3,PSME1,PTGFR,RASD1,RHOG,RPSA,SOCS3,SOD1,SPP1,STAT1,TECR,TIMP1,TP53,TPM3,TUBA1B,YWHAG	AHR,CEBPA,CEBPB,CREBBP,ERK,ERK1/2,FOS,FOXO1,IGF1,IRF8,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),PRL,RELA,SP1,STAT1	
P2	 	FLT1	1.003	kinase	 	0.000	 	0.247	-1.105	1.30E-07	APLP2,BCAT1,CAPN2,CCNI,CTBP1,EIF5A,FLNA,FOS,G3BP2,HK1,HMOX1,LAMP1,MAT2A,PREB,SCRN1,SDHC,SURF1,THBS1,TNFRSF10B,VDAC1	AHR,Ap1,EGR1,ERK,FLT1,FOS,JUN,MYC,NFE2L2,NFKB1,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,VEGFA,nitric oxide	
P2	 	dalfampridine	 	chemical drug	 	-1.796	bias	0.631	 	1.49E-07	APP,BTG2,CYR61,DUSP6,EGR1,FOS,FOSB,GADD45B,HSPA8,JUN,KLF4,NR4A1,NR4A2	Ap1,CREB1,HTT,L-glutamic acid,Muscarinic cholinergic receptor,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,dalfampridine	
P2	 	APOE	3.423	transporter	 	-0.646	bias	-0.405	1.217	1.53E-07	ADAMTS5,ADIPOQ,AGER,APOB,APOE,APP,CCND2,CD68,CTSB,CTSD,CTSS,CYBB,CYP3A5,CYR61,EDN1,EGR1,FKBP4,FKBP5,FOS,HMOX1,IL10RA,IL1RN,INSR,JUN,LEP,MAPT,MSR1,MYBBP1A,PTX3,S100A8,SDC4,SOCS3,SOD1,SPP1,SREBF2,SYP,TIMP1,VCAM1,VCP,WBP2	APOE,Ap1,CEBPA,CEBPB,FOS,IFNG,IL10,IL1B,IRF8,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,TNF	
P2	 	AGT	1.431	growth factor	Activated	3.278	bias	0.365	0.489	1.81E-07	ADAM12,ADAM17,ADAMTS5,ADIPOQ,AGER,ATP2B1,CCND2,CCND3,CLGN,CTSS,CXCL10,CYBB,CYP4A11,DAB2,DDAH2,EDN1,EGR1,ENG,FGF2,FOS,GALNT13,GFPT1,GSS,GSTP1,HIF1A,HMGCS1,HMOX1,HSPB1,IGFBP4,INSR,ITGA7,ITGAV,JUN,KCND3,LEP,MAPT,MIF,MSMO1,MSR1,NMNAT2,NPR3,NR4A1,NR4A2,PDGFA,PFN1,PIK3R1,PIR,PNKD,PTGFR,RAC1,SCN2A,SLC9A1,SOCS3,SOX6,SPP1,TGFB2,TGFBR1,TIMP1,TLN2,TNFRSF12A,TP53,UCP2,VCAM1	AGT,CEBPA,EGR1,FGF2,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TGFB1,TNF	
P2	 	MKNK1	-1.250	kinase	Activated	3.266	bias	0.721	 	1.95E-07	ANXA2,ANXA5,AP3D1,CYR61,EEF1D,FAM49A,FLNA,FOS,FOSB,GPC4,HSPA2,ISG15,MAP1B,MAPT,MYO5A,NCDN,PLTP,PLXNB2,RNH1,SFRP1,STXBP1,TMBIM6,TPP1,YWHAG	 	
P2	 	BACH1	 	transcription regulator	Inhibited	-2.143	bias	-0.388	-1.082	2.11E-07	CALM1 (includes others),FTH1,GCLM,HMOX1,ME1,NQO1,SLC7A11,SPP1,SQSTM1,TTC23	BACH1,NFE2L2,NFkB (complex),RELA	
P2	 	tert-butyl-hydroquinone	 	chemical reagent	Activated	3.165	bias	0.627	 	2.32E-07	ABCC1,AKR1C1/AKR1C2,FOS,FTH1,FTL,G6PD,GCLM,GSS,GSTP1,HMOX1,HSPA5,HSPA8,JUN,MAF,ME1,NFE2L2,NQO1,OSGIN1,RAP2A,SESN2,TXNRD1	Ap1,BACH1,EGR1,FOS,HMOX1,JUN,Jnk,NFE2L2,NFkB (complex),NRF1,RELA,STAT1,tert-butyl-hydroquinone	
P2	 	U0126	 	chemical - kinase inhibitor	 	-1.314	bias	-0.473	1.797	2.51E-07	ACKR3,ADIPOQ,ALPK3,ARHGEF2,ATF4,CCND2,CCND3,CSF1R,CXCL10,CXCL9,CYBB,DAB2,DDIT3,DUSP10,DUSP4,DUSP6,EDN1,EGR1,ETV5,FGF2,FGFR2,FKBP5,FOS,FOSB,G0S2,GADD45B,GDF15,GRN,HIF1A,HMOX1,HSF4,HSPA5,IGHA1,JUN,KCTD2,KDM6B,KIFC3,LAMP1,LAMP2,LEP,MAT2A,NR4A1,NR4A2,NXPH4,PER1,PLIN1,PRELP,PTPRJ,RAC1,SH2B3,SHB,SIRPA,SOCS3,SOX9,SPP1,STC2,SYP,TGFB2,TGFBR1,THBS1,TMEM184B,TOP3B,TP53,TPM3,TULP3,TYMP,VCAM1	Ap1,CREBBP,CTNNB1,EGF,EGR1,ERK1/2,FOS,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF,U0126	
P2	 	benzo(a)pyrene	 	chemical toxicant	Activated	2.705	bias	0.323	1.158	2.66E-07	ABCB6,ABHD4,ADAM12,AJUBA,ANXA1,ARHGDIA,BTG3,CEBPG,COL8A1,COMT,CYR61,DOK5,ENTPD5,EPHX1,FOS,G6PD,GCLM,GPC1,GSTP1,HMOX1,HRAS,HSPB1,INSR,JUN,LCP1,MAF,MAFG,ME1,NQO1,NR4A1,PGD,SFRP4,SLC1A4,SQSTM1,TAF6,TGFB2,THBS1,TP53,TXNRD1	AHR,Ap1,CREBBP,CTNNB1,EGF,EGR1,EP300,ESR1,HIF1A,HRAS,JUN,MYC,NFKBIA,NFkB (complex),PPARG,RELA,SP1,TP53,TP63,TP73,benzo(a)pyrene,estrogen receptor	
P2	 	Cg	 	complex	 	1.684	bias	0.483	-1.549	2.77E-07	ADCYAP1R1,AKR1C3,BARD1,BCAT1,BTG2,BTG3,CCND2,CXCL10,DMD,DPT,DUSP6,EGR1,ESR2,FAS,FHL1,G0S2,GJB2,GM2A,GPC1,HIF1A,HLA-A,HLA-DQA1,HMGA1,IGFBP4,ITGAV,JUN,KCNJ3,KLF4,LHCGR,LIMCH1,MAF,MAPKAPK2,MRPS6,MTPN,NPR3,NR2F6,NR4A1,NR5A2,PFKFB3,PLXND1,PTGFR,PTX3,SCUBE1,SDC4,SFRP4,SPP1,TENM4,TGFB2,TGFBR1,TIMP1,TNFRSF12A,TP53,UNG	Ap1,Cg,EGR1,ELK1,ESR1,ESR2,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,STAT1,TP53,beta-estradiol,estrogen receptor,progesterone	
P2	 	mifepristone	 	chemical drug	 	0.800	 	-0.140	1.710	2.80E-07	ABCC3,ALAS1,ALPL,ANXA1,APOE,BCAT1,C1QB,CD14,CD74,COL15A1,COL5A2,CTNNA1,CTSD,CYBB,CYP3A5,EGR1,EPHB3,FAS,FGF2,FKBP5,FOS,FTH1,HLA-DQB1,HOXA10,HSPA4,HSPA5,JUN,KIT,KLF4,KRT6B,MT-CO2,MT-CO3,NFE2L2,NME2,NPL,NPY1R,NR4A1,P2RX7,PFKFB3,RAMP3,SFRP4,SLC1A2,SPP1,SRM,TNFRSF10B,TP53	AHR,Ap1,CEBPA,CREBBP,EGR1,ELK1,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PGR,RELA,SP1,STAT1,TP53,dexamethasone,estrogen receptor,mifepristone,progesterone	
P2	 	quercetin	 	chemical drug	 	0.042	 	0.042	-0.174	2.96E-07	ARRDC4,CD63,COMT,CXCL10,CYP4A11,EDN1,EGR1,FBL,FOS,HIF1A,HMOX1,HSF4,HSPA5,JUN,LEP,MKI67,NFE2L1,NFE2L2,ODC1,PCCA,POR,PRDX5,SOD1,SOX9,TNFRSF10B,TOLLIP,TP53,VCAM1	AHR,Ap1,EGR1,ERK,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,nitric oxide,quercetin,reactive oxygen species	
P2	 	resveratrol	 	chemical drug	 	-0.050	 	-0.075	0.415	3.11E-07	ADAM17,ADIPOQ,AGER,AIF1,APP,CCND2,CD14,CNBP,CSF1R,CXCL10,CYBB,DCX,DDIT3,DYNLL1,EDN1,EGR1,ESR2,FAS,FOS,GDF15,GLB1,HDGF,HIF1A,HMOX1,HSPA5,ISG15,JUN,LEP,LITAF,MT-CO1,NDUFA13,NDUFA2,NQO1,PDGFA,PLIN1,RAN,SESN2,SOD1,SPP1,SQSTM1,TGFB2,TNFRSF10B,TNS1,TP53,VCAM1,ZNF91	Ap1,EGR1,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,nitric oxide,reactive oxygen species,resveratrol	
P2	 	EGF	-4.681	growth factor	Activated	2.319	bias	0.441	-0.955	3.16E-07	ACTN1,ADAM17,ALCAM,ARHGEF2,BTG2,CCND2,CCND3,CDC42EP1,CLCN3,CSF1R,CTSD,CXCL14,CYR61,DAD1,DDIT3,DUSP4,DUSP6,EDN1,EGR1,ENAH,ESR2,FAM89B,FGF2,FOS,FOSB,GAB2,GFPT1,GPS2,GSTP1,HIF1A,HMGCS1,HMOX1,HNRNPK,HOXB5,HRAS,IGFBP4,JUN,KRT5,LHCGR,MT-CO2,NCAM1,NR4A1,NR4A2,ODC1,PER1,PFKFB1,PHLDA2,PSMB2,PSMB4,PSMB6,PSMB7,RAC1,S100A11,S100A7,SCD,SH2B3,SLC1A2,SOCS3,SPP1,SPRY4,STAT1,SYP,THBS1,TIMP1,TNFRSF12A,TP53,VCAM1	Ap1,CEBPA,CREBBP,EGF,EGR1,ERK1/2,ESR1,ESR2,FOS,HGF,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,TGFB1,beta-estradiol	
P2	 	LY294002	 	chemical - kinase inhibitor	Inhibited	-3.931	bias	-0.561	 	3.19E-07	ABCC1,ACKR3,AKR1C1/AKR1C2,APOE,ATF4,ATP2B1,CCND2,CCND3,CCR1,CD14,CD74,CD83,CLCN3,CUBN,CXCL10,CXCL16,CYR61,DDIT3,DUSP4,DUSP6,EGR1,FAS,FGF2,FOS,FOSB,GBP1,GDF15,GRN,GSTP1,HIF1A,HIST1H4C,HMGCS1,HMOX1,HSPA5,IL1RN,INSR,ITGAV,JUN,LEP,LHCGR,LOC102724428/SIK1,MAF,MAT2A,ME1,NFE2L2,NQO1,NR4A1,NR4A2,NTRK3,PIK3R1,PLA2G2A,PLAA,PTPRJ,RAMP3,RAP2A,SCD,SEMA3C,SLC38A3,SOCS3,SPP1,THBS1,TOP2A,TOP3B,TP53,TPO,TYMP,VCAM1,ZBTB16	AKT1,Ap1,CEBPA,FOXO1,IL1B,JUN,LY294002,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF	
P2	 	INS	-2.238	other	 	0.612	 	0.079	0.229	3.30E-07	ADCYAP1R1,ALDH3A2,ASPH,CIDEA,DDIT3,EGR1,FADS3,FAS,FOS,FOSB,HIF1A,HSPA5,IGFBP4,IGKC,INSR,JUN,LEP,MT-ND4,OGT,PLIN2,SCD,SDHC,SMPD1,SOD1,SREBF2,TP53,TRIB3	ATF4,Ap1,CEBPA,CEBPB,CREB1,CTNNB1,E2F1,EGR1,ELK1,ESR1,FOXO1,FOXO3,HMGA1,IGF1,INS,IRS1,Insulin,JUN,NR1I2,PPARA,PPARG,RELA,SP1,TP53	
P2	 	HRG	-3.234	other	Activated	3.162	bias	0.721	 	3.93E-07	C1QA,C1QB,C1QC,CD74,CD83,CXCL14,FCGR3A/FCGR3B,HLA-DQA1,SPP1,TIMP1	 	
P2	 	arsenic trioxide	 	chemical drug	Activated	3.489	 	0.155	2.695	4.10E-07	ALOX5AP,CBR1,DDIT3,FAS,FTH1,GCLM,HIF1A,HMGCS1,HMOX1,HSPA5,KEAP1,MAF,ME1,MSMO1,NFE2L2,NQO1,PFKFB1,PIR,PTPRC,S100A8,SCD,SHMT2,SLC7A11,SREBF2,TNFRSF10B,TP53,TXNRD1,VDAC1	Ap1,BACH1,EGR1,EP300,FOS,FOXO1,HIF1A,Jnk,MYC,NFE2L2,NFKBIA,NFkB (complex),PML,RELA,SP1,TP53,arsenic trioxide,hydrogen peroxide,reactive oxygen species	
P2	 	miR-16-5p (and other miRNAs w/seed AGCAGCA)	 	mature microrna	Inhibited	-4.906	bias	-0.721	 	4.11E-07	ACP2,ACTR1A,ANLN,ARHGDIA,ARL2,ATG9A,CCND2,CCND3,CDC14B,CFL2,FGF2,GFPT1,GRN,HMGA1,HMOX1,IPO4,JUN,NPR3,PAFAH1B2,PANX1,PHLDB2,PSAT1,RTN4,SERPINE2,SHOC2,SLC12A2,SLC25A22,SLC38A1,SLC7A1,SQSTM1,SRPRA,SRPRB,TOMM34,TPM3,UCP2,UTP15	 	
P2	 	MAFG	2.414	transcription regulator	 	0.440	bias	0.388	-0.560	4.13E-07	ABCC3,GCLM,GSTP1,HMBS,HMOX1,MAFG,NQO1,TP53,TXNRD1	 	
P2	 	IL15	-1.317	cytokine	 	-0.008	bias	0.477	-2.301	4.60E-07	ANXA1,ARHGDIB,ATF4,BAMBI,CALM1 (includes others),CCND2,CCND3,CCR1,CD160,CD2,CD28,CD53,CD74,CD83,CXCL10,EDN1,FAS,FCGR3A/FCGR3B,FKBP1A,FYB,G6PD,GAPDH,GARS,HSPA8,IL2RG,JUN,KIT,LEP,LYPLA1,MAF,MIF,MKI67,NCAM1,NME1,OAZ1,PFN1,PLEK,POLR2K,PSAP,PSMB10,PTPRC,PTPRJ,RPS3A,S100A11,SLC25A5,TCEA1,TCF7,TIMP1,TNFRSF10B,TOP2A,TXNRD1,TYROBP,VCAM1,YARS	BCL6,CEBPB,IFNG,IL15,IL2,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	CREB1	1.138	transcription regulator	 	0.054	 	0.218	-1.437	5.01E-07	ADRA1A,ALAS1,APOE,APOLD1,ARHGAP35,ATF5,ATP5I,ATP6V0B,BCAP29,BRINP2,BTG2,CARS,CCND3,CD4,CD68,CPEB1,CSRNP1,CSRP2,CYR61,DCX,EDN1,EGR1,FGFR2,FOS,FOSB,GAA,GABARAP,GADD45B,HLA-A,HLA-DQB1,HLA-DRA,HLA-G,HMGCS1,HMOX1,HPCAL1,HSPA4,HSPA5,JUN,LEP,LITAF,MAT2A,MKNK2,MSMO1,MTSS1,MVD,NDUFA4,NEO1,NPC2,NR4A1,NR4A2,PCDH19,PDE1C,PEG10,PER1,PIM3,PNO1,RHEB,RNH1,SCD,SERINC2,SFRP4,SHTN1,SIAH2,SLC19A1,SQSTM1,SRD5A1,SSR4,TGFBR1,TPO,TXN,UQCRQ	CREB1,CREBBP,CREM,E2F1,EP300,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,SREBF1,STAT1,TSH,cholesterol	
P2	 	PML	1.262	transcription regulator	Inhibited	-2.080	 	-0.081	-1.678	5.12E-07	ACTG1,ADIPOQ,APOE,CFL1,CIAPIN1,FAS,FTL,GCLM,HADHB,HLA-DRA,HMOX1,HSPB1,LEP,LYZ,MAF,NFE2L2,NQO1,SCD,SQSTM1,SREBF2,STIP1,TP53,TXN,TXNRD1,UCP2,YWHAG	AHR,BACH1,CEBPA,CREBBP,FOXO1,HIF1A,IL1B,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PML,RELA,RXRA,TP63,arsenic trioxide,reactive oxygen species	
P2	 	amino acids	 	chemical - endogenous mammalian	 	-0.123	 	-0.216	0.541	5.21E-07	ASNS,DDIT3,FOS,FOSB,GAPDH,HIF1A,JUN,ODC1,RPL32,SLC7A1,SLC7A2	CEBPA,CEBPB,CREB1,ELK1,FOS,FOXO1,Gsk3,IGF1,Insulin,JUN,MAPK3,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,TP53,amino acids	
P2	 	palmitic acid	 	chemical - endogenous mammalian	 	0.919	bias	0.317	-0.730	5.57E-07	ADCYAP1R1,ADIPOQ,ALDOA,ATF4,ATP5J2,CIDEA,CTSB,CYBB,DDIT3,DEGS1,DGAT2,ERN1,FOS,GAPDH,GDF15,HMOX1,HSPA5,INSR,LEP,NFE2L2,NR4A1,NR4A2,PLIN2,SCD,SLC25A1,SOCS3,SQSTM1,TNFRSF10B,TRIB3,UCHL1,UCP2,VCAM1	ARNT,Ap1,CREB1,D-glucose,EGR1,FOS,FOXO1,HIF1A,Insulin,Jnk,MYC,NFKB1,NFkB (complex),P38 MAPK,PPARA,PPARD,PPARG,RELA,SP1,SREBF1,STAT1,fatty acid,palmitic acid	
P2	 	troglitazone	 	chemical drug	 	-0.778	 	0.069	-1.216	6.25E-07	ADIPOQ,AGER,ALAS1,ANXA2,ATP2B1,C9orf72,CARS,CCND2,CCND3,CEBPG,CFL1,CHCHD10,COL15A1,CRYAB,CXCL10,CXCL9,CYP3A5,DDIT3,EGR1,ENTPD5,FOS,G0S2,GDF15,GLO1,HLA-DRA,HMOX1,HSPA5,JUN,KLF4,KRT14,LEP,ME1,MKI67,MSR1,MT-ND1,NNMT,NR4A1,PCIF1,PLIN1,PLIN2,PNRC2,RASD1,SCD,SLC9A1,SORBS1,SPP1,TALDO1,THRSP,TP53,TRIB3,TRIM31,TSN,UCK1,UCP2,VCAM1	ADIPOQ,ARNT,CEBPA,CTNNB1,D-glucose,EGR1,FOXO1,HIF1A,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RXRA,SP1,STAT1,TNF,troglitazone	
P2	 	ADORA2A	-2.890	g-protein coupled receptor	 	1.489	 	0.110	0.933	6.37E-07	APP,ATP2B1,ATP6AP1,ATP6V1B2,CCT5,CD28,CSF1R,CXCL10,DGAT2,EIF2S2,EIF5A,FBL,FOS,G3BP2,GAPDH,HMOX1,HNRNPK,KIF5B,NAPA,NR4A1,NR4A2,PEA15,PGAM1,PPP1CA,PPP1R1B,TUBB2A,USP5	ADORA2A,Ap1,CEBPB,CREB1,CREBBP,DDIT3,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),Pde,Pka,Pkc(s),RELA,STAT1,adenosine,cyclic AMP,dopamine,estrogen receptor	
P2	 	ARNT	1.256	transcription regulator	Activated	3.257	bias	0.569	 	6.69E-07	ADAM17,ALDOA,ATP5G1,BHLHE41,CCND2,CLDN1,CTSD,DEGS1,EDN1,ENG,ENO1,G6PD,GAPDH,HIF1A,INSR,ITGAV,LEP,NDUFS3,NDUFS4,NQO1,OAZ1,PCK2,SIM1,TP53,TP53RK	AHR,ARNT,Ap1,EGR1,ELK1,EP300,ESR1,ESR2,HIF1A,MYC,NFKBIA,NFkB (complex),RELA,SP1,TP53,TP63,TP73,VHL,estrogen receptor	
P2	 	INSR	1.727	kinase	Activated	3.721	bias	0.485	1.238	6.82E-07	ALDH2,ARHGDIA,ARHGEF2,ATP5D,ATP5G1,ATP5J,ATP5J2,ATP5L,C1QA,CBR1,CCND2,CD83,CFL1,CRAT,CSTB,CTSB,CYCS,EDN1,EGR1,FHL1,FLNC,FOS,GANAB,GAPDH,GNB1,GRN,HADHB,HMGCS1,INSR,KIFAP3,KIT,LCP1,LEP,LYZ,MDH2,MNT,MPEG1,MSMO1,MT-CO1,MVD,NDUFA1,NDUFA4,NDUFA9,NDUFB4,NFE2L2,PHLDA2,RAB7A,RPL7A,RPS16,SOCS3,SREBF2,UCP2,VCAM1	ARNT,CEBPA,CEBPB,CTNNB1,D-glucose,FOS,FOXO1,FOXO3,HIF1A,HMGA1,IGF1,IGF1R,INSR,IRS1,Ins1,JUN,MYC,NFKB1,PPARG,RB1,SP1,estrogen receptor	
P2	 	AMPK	 	complex	 	-1.174	 	0.134	-1.717	7.28E-07	AACS,ADIPOQ,CCND2,CLDN1,CXCL10,CYBB,DUSP4,EGR1,HIF1A,HMOX1,IL1RN,LDHB,LITAF,MT-ATP6,MT-CO1,MT-CO2,MT-CYB,MT-ND1,PFKFB3,STAT1,STIM1,THRSP,TP53,UCP2	AMPK,Ap1,CREB1,FOXO1,HIF1A,Insulin,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARA,PPARG,RELA,SP1,STAT1,TNF,TSC2	
P2	 	TFEB	1.477	transcription regulator	Activated	2.996	bias	0.680	 	7.53E-07	APP,ARSA,CLCN7,CTSA,CTSB,CTSD,GBA,HEXA,LAMP1,NAGLU,PSAP,SCPEP1,TPP1	 	
P2	 	paclitaxel	 	chemical drug	 	0.980	bias	0.283	-0.263	7.81E-07	ACKR3,ALPK3,ANXA5,ARHGEF2,ATF4,BHLHE41,BTG2,CD53,CXCL10,CYP3A5,DDIT3,DUSP10,DUSP4,DUSP6,EGR1,ETV5,FAS,FLNA,G0S2,GADD45B,GDF15,HIF1A,HLA-A,HSF4,IGHA1,JUN,KCTD2,KDM6B,KIFC3,LCP1,LCP2,NXPH4,PNKD,PRELP,SH2B3,SHB,SLC12A2,THBS1,TMEM184B,TNFRSF10B,TOP3B,TP53,TUBA1B,TULP3,TYMP	AHR,EGR1,ERK,FGF2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,paclitaxel	
P2	 	progesterone	 	chemical - endogenous mammalian	Activated	2.809	 	0.220	1.204	8.83E-07	ADCYAP1R1,ADIPOQ,AKR1C3,ALPL,APOE,ATP6V1B2,BCAT1,BMP2K,C9orf72,CA3,CCND3,CES1,CNDP2,COL15A1,COMT,CRYAB,CXCL10,CYP3A5,DDIT3,EGR1,ENG,ESR2,FAM49A,FGFR2,FKBP4,FKBP5,FOS,FTH1,G6PD,GARS,GJB2,HIF1A,HLA-DQB1,HLA-G,HOXA10,HSPA2,HSPA8,INSR,JUN,KCNG1,KRT5,LHCGR,LITAF,MBP,ME1,MTSS1,MYO1D,NCAM1,NME2,NPL,NPY1R,NR4A1,PDGFA,PFKFB3,PIK3R1,PKM,PNKD,PRNP,PTX3,RTN4,SCD,SCNN1B,SFRP4,SLC1A5,SPP1,SRD5A1,SYP,TGFB2,TGFBR1,THRSP,TIMP1,TNXB,TP53,TYMP,WNT5B,YWHAG	AGT,Ap1,CREB1,CREBBP,CTNNB1,ERK1/2,FOS,FOXO1,FSH,HIF1A,Insulin,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,TP53,estrogen receptor,progesterone	
P2	 	MRPL14	1.837	other	 	-1.633	bias	0.721	 	9.87E-07	MALSU1,MT-CO1,MT-CO2,MT-ND1,MT-ND4,MT-ND6	 	
P2	 	homocysteine	 	chemical - endogenous mammalian	Activated	2.049	bias	0.335	0.660	1.04E-06	ANXA2,ATF4,CXCL10,DDAH2,DDIT3,EEF1D,FGF1,FGF2,HCAR2,HMOX1,HSPA5,LEP,MT-CO3,SAA1,SOCS3,SREBF2,TIMP1,TP53,TRIB3,VCAM1	Ap1,EGR1,FOS,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,SREBF1,STAT1,cholesterol,homocysteine	
P2	 	curcumin	 	chemical drug	 	0.749	bias	-0.276	2.560	1.05E-06	ABCC1,ADAM17,ADAMTS5,ADIPOQ,APOE,APP,ATOX1,CCND2,CCND3,CDC14B,COX7B,CSNK1A1,CTNNA1,DDIT3,EDN1,EGR1,ENTPD5,FAS,FGF2,FOS,FOSB,FTH1,FTL,GCLM,GLUL,GSTP1,HIF1A,HMOX1,HSPA8,IGFBP4,JUN,LEP,MAPT,MIF,NCAM1,NEO1,NFE2L2,NQO1,SOCS3,SOD1,SOX9,SREBF2,TCEB2,TESK1,TGFBR1,TNFRSF10B,TOP2A,TP53,UBE2E2,UCP2,VCAM1	Ap1,FOS,FOXO1,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,TP53,curcumin,hydrogen peroxide,nitric oxide,reactive oxygen species	
P2	 	CTNNB1	1.081	transcription regulator	 	0.252	bias	0.574	 	1.08E-06	ABCC1,ADAM17,ADGRG2,ADIPOQ,AES,ALCAM,ALDH3A2,ALG3,ANXA1,APP,ARHGDIA,BAMBI,BCAP31,C6,CA3,CALM1 (includes others),CAPNS1,CAPZB,CCND2,CD4,CRAT,CTNNA1,CYR61,DDIT3,EDN1,EIF5A,EPHB3,ESR2,EYA2,F13A1,FAS,FCER1G,FOS,GADD45B,GJB2,GLUL,GNA12,HDGF,HNRNPA0,HTRA1,ITGB2,ITSN1,JUN,KRT5,LFNG,LHCGR,ME1,MPEG1,NCAM1,NR5A2,P2RX7,PCCA,PCSK6,PDE1C,PFN1,PHLDA2,PIK3R1,PSAP,PTPRJ,S100A8,SAA1,SCD,SCRN1,SEC61A1,SEMA3C,SERPINE2,SFRP1,SFRP4,SLC12A2,SLC1A2,SLC1A5,SOX9,SPP1,SQSTM1,STARD7,STXBP1,SYNM,TCF7,TIMP1,TMEM2,TP53,UBA1,VCAM1,WNT5B	Ap1,CTNNB1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TCF,TNF	
P2	 	F2	-3.135	peptidase	Activated	2.748	bias	0.650	 	1.08E-06	AKR1B1,B3GNT5,CCND2,CD63,CD68,CDC42EP1,CKAP4,CTPS1,CYBB,CYR61,DOK5,EDN1,EGR1,ERP29,F2RL3,FGF2,FHL1,FOS,FOSB,HIF1A,HMGA1,HMOX1,IGFBP4,JUN,LAMP1,LAMP2,MIF,MTSS1,PDGFA,PLPP1,RAC1,RNH1,SDC4,SLC7A1,SRM,SYP,TGFB2,THBS1,TNFRSF12A,TRAF3,VCAM1	CEBPA,CEBPB,EGR1,F2,FGF2,FOS,FOXO1,IGF1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),Pdgf (complex),RELA,SP1,STAT1,TGFB1	
P2	 	PRKAG3	-3.915	other	 	 	 	 	 	1.13E-06	ACKR3,ALAS1,ASPH,ATP6V1A,BTG2,CES1,CLCN3,CTNNA1,DUSP10,EGR1,FTL,GAS5,GBE1,GOT1,HSPA5,IFI30,KLF4,LEP,LMCD1,MAT2A,NEO1,ODC1,PHLDA3,PPP1R14B,RPE,RPL12,SLC40A1,SLC7A2,SNCG,THRSP,TRIM16	 	
P2	 	SP1	1.074	transcription regulator	Activated	3.012	bias	0.627	 	1.17E-06	AGER,ALDH3A2,ALPL,APOE,ASNS,ASS1,ATP6V0C,C1QBP,CCND2,CCND3,CD28,CES1,COL8A1,CRYAB,CTSD,CXCL10,DMD,EGR1,ENG,FAS,FGF2,FLNA,FOLR2,FOS,GDF15,GSS,HADHB,HIF1A,HINT1,HMGA1,HMOX1,HSPA5,IGFBP4,INSR,ITGAV,JUN,KIT,KLF4,LHCGR,MAT2A,MAZ,NPTXR,NR5A2,P2RX7,PDGFA,PDGFC,PKM,PLAA,PREX1,PRKRA,SERPINE2,SLC19A1,SLC25A5,SLC31A1,SLC4A2,SLC7A1,SMPD1,SNCG,SOD1,SOX9,SPP1,SPTB,STAT1,TGFB2,TGFBR1,TIMP1,TNFRSF10B,TP53,TSPO,TXNRD1	AHR,APP,ARNT,CTNNB1,EGR1,ESR1,ESR2,FOS,FOXO1,FOXO3,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),NR3C1,RB1,RELA,SP1,STAT1,TP53,TP63,TP73,Vegf,estrogen receptor	
P2	 	RELA	1.432	transcription regulator	Activated	2.289	bias	0.497	-0.497	1.19E-06	ADAMTS5,ALCAM,AP1B1,APOE,APP,ARHGDIB,BTG2,CD14,CTSB,CXCL10,CXCL9,CYBB,DDIT3,EDN1,EGR1,ERAP2,FAS,FCGRT,FGF2,FMN2,FOS,GBP1,GDF15,HIF1A,HMOX1,IGKC,IL1RN,ISG15,JUN,KIT,MAT2A,MIF,MT-CYB,NFE2L2,NR4A1,PI3,PI4KA,PSMB10,PTX3,SAA1,SAA2,SBF1,SDC4,SERPINE2,SLC1A2,SLC2A5,SOX9,SREBF2,STIM1,SYTL1,TNFRSF10B,TP53,TPO,VCAM1	Ap1,CDKN2A,CEBPA,CEBPB,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	IPMK	1.147	kinase	 	-0.283	bias	0.721	 	1.20E-06	CAPNS1,CYR61,FLNA,FLNC,FOS,FOSB,JUN,MYL9,PER1,PFN1	Ap1,CREBBP,FOS,IPMK,JUN,NFkB (complex),RELA	
P2	 	VEGFA	-1.415	growth factor	 	1.928	bias	0.551	 	1.20E-06	ABCC1,ALAS1,ALDH2,ATP5J2,CD160,CD83,CSTB,CTSB,CTSS,CXCL10,CYR61,DUSP4,EDN1,EGR1,ETV5,FGF2,FOS,GBP1,HIF1A,HK1,HMOX1,IGFBP4,MDH2,ME2,NDUFA1,NME1,NME2,NR4A1,SCO2,SDHB,SHMT2,SLC25A5,SLC25A6,SNCG,SYNM,THBS1,TMSB10/TMSB4X,TP53,TSPO,UNC5B,VCAM1	AHR,Ap1,CREBBP,EGR1,FGF2,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,TP53,VEGFA	
P2	 	PDGF BB	 	complex	 	0.378	bias	0.430	-2.254	1.29E-06	ACKR3,ATP2B1,CALM1 (includes others),CBX4,CCND3,CRYAB,CSF1R,CSRP2,CYCS,CYR61,DAB2,DDIT3,DUSP6,EDN1,EGR1,FHL1,FLNA,FMO1,FOS,FOSB,GDF15,GLUL,GSS,HMGCS1,HMOX1,HRAS,IGFBP4,JUN,MAT2A,NPR3,NR4A1,NR4A2,ODC1,PDGFA,PSMB4,RPN2,SCD,SLC7A1,SOCS3,THBS1,TIMP1,TNFRSF12A,TP53,TRIB3,TRIOBP,UCK1,UNC5B,VCAM1	AHR,Ap1,CEBPA,EGR1,ERK,FGF2,FOS,JUN,Jnk,MYC,NFKB1,NFkB (complex),P38 MAPK,PDGF BB,RELA,SP1,STAT1,TGFB1	
P2	 	tetrachlorodibenzodioxin	 	chemical toxicant	 	1.188	 	0.039	0.974	1.36E-06	AARS,ABCB6,ACTN1,ASNS,ATF4,ATP2B1,BCAT1,CA3,CBR1,CES1,CHST2,CMA1,COMT,CTSD,CYP4A11,CYP4B1,CYR61,DMXL2,EDN1,FAS,FOS,GHITM,HMOX1,HRAS,HSPA2,HSPA8,IL10RA,ITGA7,JUN,KRT14,LHCGR,NFE2L2,NME1,NMT2,NQO1,ODC1,POMP,PTGFR,RAB10,S100A8,SAA1,SHB,SIM1,SLC25A5,SLC38A3,SLC40A1,SLC4A2,SLCO2B1,SOD1,STC2,TGFB2,TP53,TXN	17-alpha-ethinylestradiol,AHR,Ap1,CEBPA,ERK,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,TNF,TP53,tetrachlorodibenzodioxin	
P2	 	25-hydroxycholesterol	 	chemical reagent	 	-0.781	 	0.096	-1.166	1.38E-06	ASNS,ATF4,CHAC1,DDIT3,FCER1A,FOS,FOSB,HMGCS1,HMOX1,HSPA5,JUN,NR4A1,NR4A2,PIK3R3,SCD,SREBF2,TRIB3	25-hydroxycholesterol,AHR,Ap1,CREBBP,EGR1,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SREBF1,arachidonic acid,cholesterol	
P2	 	FSH	 	complex	 	0.985	bias	0.259	-0.330	1.44E-06	ACP2,ACTN1,ADAM17,ALDH3A2,ALPL,ARHGAP35,ARPC4,ATP2B1,BCKDK,BTG2,CCND2,CDK16,CITED1,CLIP1,COL15A1,CSNK1A1,DAB2,ESR2,FGF2,FKBP5,FLNC,FOS,FOSB,GBP1,GDE1,GNB1,GOT1,IGFBP4,IL1RN,JUN,KIF5B,LHCGR,MAP4K4,MSMO1,NEO1,NPC2,NPY1R,NR4A1,P4HA2,PCSK6,PKM,PLPP1,PPP1R2,PRNP,RAB5C,SRD5A1,STAT1,STIP1,TGFB2,TGFBR1,THBS1,TIMP1,TMBIM6,TNFRSF10B,TP53	AHR,CEBPB,CREB1,CREBBP,ERK,ERK1/2,ESR1,FOS,FSH,JUN,Lh,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,STAT1,cyclic AMP,estrogen receptor,progesterone	
P2	 	CEBPB	2.050	transcription regulator	Activated	3.497	bias	0.461	0.362	1.48E-06	ADIPOQ,AKR1C3,ALOX5AP,APOB,ASNS,CCND2,CD14,COL5A2,CSF1R,DAB2,DDIT3,DEGS1,DGAT2,DYNLT1,FAS,FGFR2,FHL1,FOS,FTL,HIST1H4H,HLA-A,HMGA1,HSPA8,IGFBP4,IGKC,IL1RN,INSR,JUN,KRT6B,LCP2,LEP,LHCGR,MBP,MSR1,NFE2L1,NUPR1,ODC1,PEA15,PI3,PLXND1,PSMA3,PSMA6,PTGFR,SAA2,SCD,SEPT3,SLC12A2,SLC7A1,SOCS3,SPP1,TLR8,TMEM176A,TMEM176B,TP53,TRIB3,UBA2	Ap1,CEBPA,CEBPB,EGR1,FOS,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SMARCA4,SP1,SPI1,STAT1,cyclic AMP	
P2	 	6-hydroxydopamine	 	chemical toxicant	Activated	2.955	bias	0.326	1.645	1.57E-06	ATF4,DDIT3,FOS,FOSB,HSPA4,HSPA5,HSPA8,HSPA9,JUN,LONP1,MT-CO1,NCAM1,NR4A2,PSMB2,PSMC4,RPL29,TP53,TRIB3,UBE2D3,VCP	6-hydroxydopamine,Ap1,EGR1,EIF2AK3,FOS,FOXO1,FOXO3,Gsk3,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT1,TP53	
P2	 	camptothecin	 	chemical drug	Activated	2.052	 	0.211	0.821	1.58E-06	ADO,AGER,ALDOA,ANXA2,APOE,ARHGDIA,BAMBI,BTG2,BTG3,CCR1,CD53,CD83,CHAC1,CHST11,CIDEA,CLTB,DUSP10,DUSP6,EDN1,EEF1B2,FAS,FOS,FOSB,GADD45B,GAPDH,GDE1,GLIPR1,HIF1A,HLA-A,HLA-DQA1,HLA-DQB1,HLA-G,IL10RA,IL17RA,ITGA7,ITSN1,JUN,KIF3B,LIMCH1,LITAF,MAP4K4,MBOAT7,MFSD5,MYO5A,NR4A1,NR4A2,PHLDA2,PI3,PIK3CG,PLIN2,PPFIBP2,PPIA,PSMD2,PTPRK,PTX3,RHEB,RRAGD,RRM2B,SAA1,SDC4,SIAH2,SIPA1L1,SLC25A5,SPP1,STC2,TBC1D31,TLN2,TNFRSF10B,TP53,TPP1,TRAF3,TUBB,TUBB2A,UBE2A,VAC14,VCAM1	AHR,Ap1,CEBPB,EGR1,ERK,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,camptothecin	
P2	 	FN1	-1.209	enzyme	 	1.677	bias	0.404	-0.508	1.68E-06	APLP2,APOE,APP,BCAT1,CAPN2,CCNI,CD83,CTBP1,CTSD,DLGAP4,EIF5A,FGF2,FLNA,FOS,G3BP2,HK1,ITGAV,LAMP1,MAT2A,PREB,RRAGD,SCRN1,SDC4,SDCBP,SDHC,SLC9A1,SOCS3,SOX9,SPP1,SQSTM1,SURF1,THBS1,TNFRSF10B,TOR1A,VDAC1	Ap1,CEBPB,EGR1,ELK1,ESR1,FN1,JUN,MAP2K1,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TP53	
P2	 	doxorubicin	 	chemical drug	Activated	3.710	bias	0.259	1.888	1.79E-06	ABCC1,ABCC3,ANXA1,ANXA2,APP,ASNS,BARD1,BTG2,CAMK2D,CAPN6,CD14,CTSB,CTSD,CYBB,CYR61,DDIT3,EDN1,EEF1B2,EFEMP2,EGR1,EIF5A,FAS,FOS,FTH1,GAS5,GDF15,GLB1,GLIPR1,GSS,HIF1A,HMOX1,IRF5,JUN,NCAM1,NFE2L2,NLRC4,NQO1,OSGIN1,PIK3R3,PSAP,PSMB10,RRM2B,S100A11,SOD1,SOX9,SPP1,STAT1,TIMP1,TNFRSF10B,TNFRSF12A,TOP2A,TP53,TUBB,TXN	AHR,Ap1,CREBBP,EGR1,FOS,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RB1,RELA,SP1,TP53,TP63,TP73,doxorubicin	
P2	 	thapsigargin	 	chemical toxicant	 	1.646	bias	0.374	-0.316	1.92E-06	ADCY1,ADIPOQ,ASNS,ATF4,CD83,CHAC1,CXCL10,DDIT3,EDN1,EGR1,FOS,GADD45B,HIF1A,HMOX1,HSPA5,HSPA9,ITGB2,JUN,KLF4,KPNA1,LONP1,NFE2L2,NR4A1,PCK2,PRNP,SESN2,THRSP,TNFRSF10B,TP53,TPO,VCAM1	AHR,Ap1,CREBBP,EGR1,EIF2AK3,FOS,FOXO1,FOXO3,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,thapsigargin	
P2	 	ALDH2	-2.164	enzyme	Inhibited	-3.148	bias	-0.721	 	1.99E-06	ATF4,ATF5,GCLM,GSS,PSAT1,SHMT2,SLC1A4,SLC3A2,SLC7A11,SLC7A5	 	
P2	 	IL6	-1.873	cytokine	 	1.758	bias	0.379	-1.251	2.12E-06	ABCC1,ABCC3,ADAMTS5,ALAS1,ANXA1,APOB,APOE,APP,BTG2,CCR1,CD14,CD163L1,CD209,CD53,CD68,CD74,CD83,CES1,CES2,CXCL10,CYBB,CYP3A5,DPP3,DUSP6,DVL1,EGR1,ESR2,FAS,FCGRT,FGF2,FOS,GADD45B,HIF1A,HLA-A,HLA-DQA1,HMOX1,HSPA5,IGFBP4,IL1RN,ITGAV,JUN,KCTD13,KIT,KRT14,LEP,LHCGR,LYZ,MAF,MKI67,MSR1,PDGFA,PLA2G2A,PRNP,PSMB10,PSME1,PTGFR,PTPRC,RNASE6,S100A7,SAA1,SAA2,SH3GLB1,SLC12A2,SLC14A1,SLC40A1,SNX10,SOCS3,SPP1,SRA1,STAT1,STS,SYP,TBC1D9,THBS1,THRSP,TIMP1,TLR8,TNFRSF10B,TOP2A,TP53,TRAF3,VCAM1,WARS,WHSC1,XPNPEP2	CEBPA,CEBPB,IFNG,IL1A,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	CST5	-1.151	other	Inhibited	-2.160	bias	-0.350	0.107	2.15E-06	ABCC1,ADRM1,AKR1C1/AKR1C2,ANXA2,ANXA5,AP3D1,ARHGEF2,BCAP31,CNBP,COPS7A,COPS8,CTSB,DNAJB11,EEF1B2,EEF1D,FHL1,FRAS1,GNL3,HS2ST1,INTS1,MAL2,MALSU1,MAP1B,MNT,MYL9,NDUFC2,NHP2,NPAS2,PDCL3,PRKACB,PRKRA,PYGB,RTN3,S100A11,SEPT3,SGPL1,SLC1A3,SLC7A11,SUPV3L1,TXN,UTP18,VDAC1,WDR36	 	
P2	 	bicuculline	 	chemical - endogenous non-mammalian	 	-1.877	bias	0.499	-3.649	2.15E-06	APP,BTG2,CYR61,DUSP6,EGR1,FOS,FOSB,GADD45B,HSPA8,JUN,KLF4,NR4A1,NR4A2	CREB1,CREBBP,Cg,EGR1,ELK1,ERK1/2,FOS,HTT,Hdac,L-glutamic acid,NFKBIA,NFkB (complex),RELA,SP1,SP3,bicuculline,dopamine,estrogen receptor	
P2	 	deferoxamine	 	chemical drug	 	-0.020	bias	0.319	-1.637	2.30E-06	ALDOA,APP,CCND2,CCND3,CYP3A5,DDIT3,DUSP10,EGR1,ENO1,FOS,GADD45B,GDF15,HIF1A,HMOX1,HSPA13,IGFBP4,LEP,MT-CYB,MT-ND5,NR4A2,PFKFB1,PFKFB3,PKM,SERPINE2,SPP1,SPRY4,TGFB2,TNFRSF10B,TP53,VCAM1	AHR,Ap1,CREBBP,HIF1A,HTT,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TP53,VHL,deferoxamine,iron	
P2	 	15-deoxy-delta-12,14 -PGJ 2	 	chemical - endogenous non-mammalian	 	-0.902	 	-0.229	0.338	2.34E-06	CCND2,CTSB,CTSD,CXCL10,CXCL9,CYBB,DDIT3,EGR1,FKBP4,FOS,FTH1,GCLM,GDF15,GSTP1,HLA-DRA,HMOX1,HSPB1,JUN,KLF4,LAMP1,MSR1,NFE2L2,NQO1,RARRES3,SLC9A1,SOCS3,SOD1,SPP1,STAT1,TP53,TXNRD1,VCAM1	15-deoxy-delta-12,14 -PGJ 2,Ap1,CEBPA,FOS,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF,dexamethasone,nitric oxide	
P2	 	BDNF	-1.812	growth factor	 	-1.532	bias	0.288	-3.283	2.47E-06	ANXA2,ANXA5,AP3D1,APP,CCND2,CYGB,CYR61,DUSP4,DUSP6,EEF1D,EGR1,FAM49A,FLNA,FOS,FOSB,FTL,GLUL,GPC4,HSPA2,HSPA5,JUN,LEP,MAP1B,MAPT,MBP,MVD,MYO5A,NCAM1,NCDN,NR4A1,PFKFB3,PLTP,PLXNB2,PPP1R1B,RNH1,RPL37A,RPS23,SFRP1,SPP1,STXBP1,SYP,TMBIM6,TPP1,TRAF3,YWHAG	Ap1,BDNF,CREB1,CREBBP,ELK1,FOS,FOXO1,FOXO3,HTT,JUN,L-glutamic acid,MAP2K1/2,MAPK3,NFKBIA,NFkB (complex),NR3C1,Pde,Pka,RELA,STAT1,TP53,corticosterone	
P2	 	CREBBP	-1.060	transcription regulator	 	0.827	bias	0.471	-0.899	2.47E-06	ADAM12,ALAS1,BANK1,CAMK2D,CAPG,CCND2,CCND3,CD160,CD53,CRISPLD2,CTSG,CXCL10,CXCL9,CYBB,CYR61,DCX,DUSP4,EGR1,EYA2,FGF2,FOS,FOSB,GM2A,GNG2,HLA-DRA,HLA-G,HMGCS1,IL10RA,ISG15,JUN,KCTD1,KRT14,MAF,MAFG,MCF2L,NFE2L2,NPAS2,NR4A1,NR4A2,NTRK3,PDLIM4,PPFIBP2,RGL1,RNF157,SDC4,SDHC,SERPINE2,SLC1A2,SLC7A11,SOCS3,THRSP,TNFRSF10B,VCAM1,WNT5B	AHR,CREB1,CREBBP,CREM,CTNNB1,EP300,FOXO1,HIF1A,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT1,TP53,estrogen receptor	
P2	 	methapyrilene	 	chemical drug	 	1.886	 	-0.069	2.177	2.50E-06	ACTG1,ALDOA,ANXA2,ANXA5,APOE,ASS1,ATF4,ATP6V1B2,BTG2,CES1,CTSB,CTSS,CYP4A11,DDIT3,GSS,GYS2,HMOX1,HSPA5,NR2F6,ODC1,PPP1R2,RPS8,SCD,SLC3A2,TP53,TUBB,TXNRD1	 	
P2	 	MEL S3	 	chemical - kinase inhibitor	 	-0.905	bias	-0.273	0.002	3.08E-06	ATP5D,C1QBP,COPS8,EGR1,ENO1,ERP29,GLOD4,PCK2,PGAM1,STIP1,TUBB	 	
P2	 	bisphenol A	 	chemical - endogenous non-mammalian	 	1.463	bias	0.504	 	3.30E-06	ADIPOQ,ALAS1,ALDH5A1,APOB,ATP6AP1,CTSD,CXCL10,EGR1,ENO1,ESR2,FOS,LAMP2,LCP2,LEP,LHCGR,MDH2,NR4A1,NR4A2,PEBP1,PKM,RPN2,SLC1A5,SRD5A1,TP53	ADIPOQ,CREB1,CREBBP,CTNNB1,EGR1,ERK1/2,ESR1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PRL,RELA,SP1,STAT1,STAT5B,bisphenol A,estrogen receptor,progesterone,testosterone	
P2	 	CAV1	-1.178	transmembrane receptor	 	-0.359	 	0.139	-0.860	3.37E-06	ADAM17,ADGRG2,ADIPOQ,CD14,CSF1R,EGR1,FAS,FOS,HMOX1,HSPA8,INSR,KRT6B,LEP,NQO1,NR4A1,RAC1,RPL17,RPS13,SLC12A2,SLC14A1,SLC7A2,ST6GALNAC4,THBS1,TP53,TXNL4A	AKT1,CAV1,ELK1,FOXO1,HMOX1,Mek,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,P38 MAPK,RELA,SP1,STAT1,TNF,TP53	
P2	 	SNCA	-1.077	enzyme	 	0.156	 	-0.062	0.291	3.59E-06	AIF1,CFL1,CTSB,CYBB,DDIT3,GLO1,HSPA5,KIF2A,LDHB,MDH2,PSMA3,PYGB,SYP,TP53,TRIB3,TUBG1,UCHL1,YWHAG,YWHAH	26s Proteasome,APP,Ap1,ESR1,FOS,FOXO1,HIF1A,HSF1,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SNCA,STAT1,reactive oxygen species,rotenone	
P2	 	tamoxifen	 	chemical drug	 	-0.667	 	0.072	-1.066	3.70E-06	ACKR3,ADORA1,ASS1,CTSD,CYP3A5,CYR61,EPHX1,ESR2,ETV5,F13A1,FLOT1,FOS,G0S2,GAPDH,GDF15,GJB2,HMGCS1,IGFBP4,IL1RN,JUN,MIF,MKI67,MT-CO1,NNMT,PFN1,RAMP3,SCD,SDC3,SLC1A2,SLC5A3,SLC7A2,SLC7A5,SLC9A3R1,SOX9,SPP1,SQSTM1,TP53,TXN,TYMP,UCP2	AHR,CEBPA,CEBPB,CTNNB1,EGR1,ESR1,ESR2,FOXO1,IGF1,JUN,MYC,NFkB (complex),RELA,SP1,TCF,TGFB1,TP53,estrogen,estrogen receptor,tamoxifen	
P2	 	E. coli serotype 0127B8 lipopolysaccharide	 	chemical - endogenous non-mammalian	 	1.057	 	0.222	-0.193	4.28E-06	ADGRG2,ADIPOQ,ADORA1,ANXA1,CD14,CHST11,CXCL10,CXCL16,DDIT3,DERL1,EDEM1,FGF1,FGF2,GJB2,GLUL,GNG2,HCAR2,HMOX1,HSPA5,IRF5,PANX1,PCK2,PPP1R1B,PRDX5,SLC1A2,SLC4A2,SLC7A11,SLC7A5,SOCS3,STAT1,SYNM,TGFBR1	CEBPB,CREBBP,CSF2,E. coli serotype 0127B8 lipopolysaccharide,EGR1,IFNG,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	CSF3	-23.910	cytokine	 	-0.206	 	0.184	-1.178	4.35E-06	ARHGDIA,C3AR1,CAPG,CCND2,CCND3,CD14,CTSD,CYBB,DUSP6,EDN1,EGR1,ERAP2,FOS,GADD45B,HLA-DQA1,HLA-DRA,HMOX1,HOXA7,IL1RN,ITGB2,JUN,KIT,LYZ,NME2,ODC1,PLCB2,SOCS3,TLR8,TP53,VCAM1	CEBPB,CSF3,IFNG,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1	
P2	 	IGF1R	1.018	transmembrane receptor	 	1.339	bias	0.434	-0.888	4.35E-06	APP,ATP5D,ATP5G1,ATP5J,ATP5J2,ATP5L,CD53,CD68,CTSD,CYCS,DDIT3,EDN1,FLNC,FOS,HIF1A,HSPA5,IGFBP4,KRT5,KRT6B,LHCGR,NDUFA1,NDUFA4,NDUFA9,NDUFB4,NR4A1,PHLDA2,RAC1,SNCG,TP53,TPO	ATF4,Ap1,CREB1,E2F1,EGR1,FOS,FOXO1,IGF1R,INSR,Insulin,JUN,Jnk,NFkB (complex),NR1I2,PPARA,PPARG,RELA,SP1,STAT1	
P2	 	EDN1	-11.809	cytokine	 	0.910	bias	0.567	 	4.43E-06	ADAM12,ADIPOQ,ANXA1,ANXA5,CYBB,EDN1,EGR1,FGF2,FOS,FOSB,GRN,HIF1A,HSPA5,HSPA8,INSR,ITGAV,JUN,LEP,MBP,NUPR1,ODC1,PDGFA,PDIA6,RAMP3,RPSA,SLC1A2,SOCS3,SOD1,THBS1,TIMP1,TP53,TPM3,VCAM1	CREBBP,EDN1,ERK1/2,FOS,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,TNF,TP53	
P2	 	indomethacin	 	chemical drug	Activated	3.287	 	0.212	2.053	4.63E-06	ADAMTS5,ANXA1,ANXA2,APP,ASNS,ATP6V0B,BTG2,CAPN2,CAPN6,CBX4,CD14,CLDN1,CTSD,DYNLL1,EFEMP2,FCGR2A,FGF2,FOS,GAS5,GBA,GDF15,HIF1A,HMOX1,INSR,PLIN2,PSMB10,RPS21,S100A11,S100A8,SLC7A5,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TNFRSF12A,TUBB,UCP2,UQCR10	Ap1,CEBPA,EGR1,ELK1,ESR1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,TNF,TP53,indomethacin	
P2	 	DOT1L	-1.010	phosphatase	 	 	 	 	 	4.63E-06	EDN1,HOXA10,PPIA,RPL19,RPL41,RPLP0,RPS2,RPS23,TUBA1C	 	
P2	 	CSF1	1.834	cytokine	Activated	2.302	bias	0.516	 	4.93E-06	APOE,CCND2,CD163L1,CD209,CD68,CPM,CSF1R,EGR1,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FOLR2,FOS,GDF15,HSPA5,IL10RA,IRF5,ITGAV,JUN,MSR1,PTPRC,PTPRJ,SFRP1,SIGLEC1,STAB1,STAT1,THBS1,TP53,VCAM1	BCL6,CEBPB,CSF1,IFNG,IL10,IL2,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	Pro-inflammatory Cytokine	 	group	 	1.526	bias	0.551	 	5.28E-06	AKR1B1,APOE,ASS1,FGF2,GLUL,HMOX1,HSPA5,LGALS9,NFE2L2,NR4A1,PI3,S100A1,SDC4,SOCS3,TIMP1,VCAM1	CTNNB1,EGR1,FOXO1,FOXO3,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pro-inflammatory Cytokine,RELA,SP1,SREBF1,STAT1,VEGFA,Vegf,cholesterol	
P2	 	maslinic acid	 	chemical - endogenous non-mammalian	Inhibited	-2.449	bias	-0.572	 	5.31E-06	ACTN1,ADAM17,ARPC4,CCND2,CFL1,DVL1,FBXW5,IL2RG,IRAK1,PIK3R1,PLCB2,PTPA,SLC1A2,SLC1A3,SORBS1,TGFBR1,THBS1,TP53,YWHAG	AHR,ERK,JUN,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,maslinic acid	
P2	 	CD28	3.704	transmembrane receptor	Inhibited	-2.779	bias	-0.351	-0.391	5.64E-06	AHCYL1,ANXA1,AP1B1,ARHGDIB,BIN1,CCND2,CCND3,CLIP1,CYCS,DAD1,FBL,FCER1G,FKBP2,FOS,FYB,GAPDH,GBP1,GYS1,HAX1,HINT1,HIST1H2AC,HLA-DQB1,HSPA8,IL10RA,JUN,LCP1,MAF,MMRN1,MSR1,MT-CO1,NR4A1,OAZ1,ODC1,PGAM1,PHB2,PSMA6,PTPRJ,RPL30,SEC61B,SLC25A5,SLC5A3,SLC7A5,SNRPC,SOCS3,SRPRB,STIM1,TCF7,THBS1	BCL6,CD28,CD3,CREBBP,IL10,IL2,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TCF3,TCR	
P2	 	SPI1	1.440	transcription regulator	Activated	3.918	bias	0.282	2.718	5.67E-06	C1QC,C3AR1,CCND2,CD14,CD209,CD68,CSF1R,CTSS,CYBB,DAB2,DUSP6,FCER1A,FCER1G,FCGRT,FOS,FTH1,HMBS,HSPA8,IL1RN,IMP4,ISG15,ITGB2,JUN,KIT,KLF4,LYZ,MBP,NOL6,PIK3CG,PSMB10,PTPRC,RPL18,SNU13,SPP1	Ap1,FOS,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,RNA polymerase II,SP1,SPI1,STAT1,TNF	
P2	 	NFkB (complex)	 	complex	Activated	4.053	bias	0.643	 	5.70E-06	AGER,APOE,APP,B3GNT5,BAMBI,CAMK2D,CAPNS1,CCND2,CD74,CD83,CXCL10,CXCL9,CYBB,CYP3A5,CYR61,DAD1,DDIT3,DOK5,DVL3,EDN1,EGR1,ERAP2,FAS,FGF1,FGF2,FOS,FTH1,FUCA1,G0S2,GADD45B,GDF15,HDGF,HIF1A,HLA-A,HMOX1,HSPA9,HSPB1,IGHG3,IGKC,IL10RA,IL1RN,ISG15,ITGAV,JUN,KCND3,KDM6B,KIT,KRT6B,LAMP2,LITAF,MT-CO2,MTSS1,NCAM1,NR1D1,ODC1,PEA15,PIM3,PTX3,SAA1,SDC4,SLC2A5,SLC7A1,SLC7A5,SOCS3,SPP1,STIM1,TIMP1,TNFRSF10B,TOLLIP,TP53,TPO,TRAF3,TRIB3,VCAM1	AHR,Ap1,CEBPA,CEBPB,CREBBP,FOS,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	desmopressin	 	biologic drug	 	-1.574	bias	0.360	-2.451	5.99E-06	AKR1B1,CAPG,CTSD,ENO1,FLNA,FOS,GAPDH,HINT1,HSPA8,HSPH1,LDHB,PHLDB2,PPIA,PPP1R1B,S100A11,SCNN1B,SEC61B,TNS1,TUBB,VDAC1	 	
P2	 	IRF8	1.390	transcription regulator	 	-0.062	bias	0.390	-1.862	6.07E-06	BANK1,BCOR,CD14,CD4,CD74,CD83,CSF1R,CTSS,CXCL16,CYBB,DAB2,EGR1,FAS,FOS,GBP1,IL17RA,IRF5,ISG15,KLF4,MAF,MAP4K4,MSR1,STAT1,TP53,TYROBP	CEBPA,CEBPB,CREBBP,IFNG,IL10,IL1B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	dinoprost	 	chemical - endogenous mammalian	 	0.678	bias	0.261	-0.304	6.71E-06	AKR1C1/AKR1C2,CCND2,EDN1,FGF2,FOS,GSTP1,HSPA4,JUN,LHCGR,NR4A1,NR4A2,POR,PTGFR,PTX3,SPP1,THBS1,THRSP,YWHAG	Ap1,CREBBP,EGR1,ERK1/2,FGF2,FOS,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),Pkc(s),RELA,SP1,STAT1,TNF,dinoprost	
P2	 	FGF1	4.419	growth factor	 	1.085	 	-0.109	1.557	7.03E-06	AKR1B1,APOE,CYR61,DUSP6,EDN1,EGR1,FOS,GCLM,GSTP1,HMOX1,JUN,NFE2L2,NQO1,NR4A2,ODC1,PDGFA,RFLNB,SLC7A2,SPP1,TGFB2,THBS1,TNFRSF12A,VCAM1	AHR,APOE,CREB1,CTNNB1,EGR1,ERK,FGF1,FGF2,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,SRC,STAT1,TNF	
P2	 	TO-901317	 	chemical reagent	Activated	2.042	 	0.230	1.104	7.06E-06	ALAS1,ALDH2,ALDH3A2,APOC1,APOE,APP,ASS1,CFH,CIDEA,COMT,COX17,CRAT,CYP3A5,CYP4A11,DNASE1L3,ENO1,EPHX1,FMO1,G6PD,GBE1,IGFBP4,MPEG1,MRPS2,NR1D1,NR5A2,PFKFB3,PFKL,PLTP,POR,PSMB2,PSME1,SCD,SIGMAR1,SYP,THRSP,TIMP1	CEBPA,ESR1,FOXO1,JUN,NFE2L2,NFkB (complex),NR3C1,PGR,PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,THRB,TO-901317,cholesterol,estrogen receptor,progesterone	
P2	 	MTOR	1.474	kinase	Activated	2.275	 	0.146	1.498	7.25E-06	AKR1B1,ATP2B1,DDAH2,DDIT3,DMD,ENO1,EPRS,FKBP1A,HADHB,HIF1A,HSPB1,IRAK1,LEP,LHCGR,MAPT,MBP,MDH2,MT-CO1,MT-TY,NCAM1,PFN1,PGP,PIP5K1C,PKM,PRDX5,PYGB,RAP1GDS1,RHEB,RPL12,RPL32,SLC12A2,SMPD1,SNCG,SOCS3,SOD1,SQSTM1,STAT1,TCEB2,TXNL1,VCAM1	Ap1,CEBPA,CEBPB,CREB1,EP300,FOS,FOXO1,Gsk3,JUN,MTOR,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PRKACA,RELA,SP1,STAT1,TNF,TP53,sirolimus	
P2	 	POR	2.765	enzyme	Inhibited	-2.227	bias	-0.282	-1.180	7.39E-06	ABCC3,ACTG1,ANXA5,ASNS,ATF5,CD74,CPA3,CYP4A11,ENTPD5,FGF1,GADD45B,HADHB,HIF1A,HLA-A,HLA-DQA1,HLA-DQB1,HMGCS1,HMOX1,HSPH1,MSMO1,MVD,PFKFB3,PGD,PMVK,POR,PRNP,SCD,SDC4,SREBF2,STAT1,TMEM176A	ARNT,EP300,HIF1A,HTT,JUN,MYC,NFE2L2,NFkB (complex),POR,RELA,TP53,TP73,VHL,doxorubicin,iron	
P2	 	IL13	-28.945	cytokine	Activated	2.763	bias	0.301	0.689	7.70E-06	ACKR3,ADORA1,ALOX5AP,BZW2,C3AR1,CAPN2,CD14,CD163L1,CD209,CD4,CD52,CHST2,CTSB,CTSS,CYBB,DMXL2,DUSP10,EGR1,F13A1,FAM162A,FAS,FCGR2A,FKBP1A,FLOT1,G0S2,G6PD,HK1,HMOX1,HTRA1,IARS,IL1RN,MAF,MCUR1,MS4A4A,MSMO1,MTSS1,NHLH1,PDGFA,PDGFC,QSOX1,S100A8,SLC7A2,SOCS3,SPP1,ST3GAL6,STXBP1,SYNGR2,THBS1,TIMP1,TNS1,TPSAB1/TPSB2,VCAM1	CEBPA,CEBPB,CREBBP,EGR1,IFNG,IL10,IL13,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF	
P2	 	LDL	 	complex	Activated	3.112	bias	0.366	1.226	7.73E-06	APOE,CAPN2,CD68,CXCL10,CYBB,DDIT3,EGR1,FOS,FOSB,G0S2,GCLM,HIF1A,HMOX1,HSPA5,HYOU1,IGFBP4,IL10RA,IL1RN,ITGAV,JUN,MKI67,MSC,MSR1,NME1,NPC2,NR4A1,NR4A2,PANX1,PLIN2,S100A8,SIGLEC1,SOCS3,SREBF2,TGFBR1,TP53,UBE2K,VCAM1	Ap1,CEBPA,JUN,LDL,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),Pkc(s),RELA,SP1,STAT1,TNF,lipopolysaccharide	
P2	 	PTEN	-1.366	phosphatase	 	-0.847	 	-0.044	-0.547	7.76E-06	ADIPOQ,AKR1C3,ALG3,ANXA1,ARHGDIA,ASPH,ATP5G1,ATP5I,BTG2,CA3,CBX4,CCND3,CST6,CSTF3,CTSB,CXCL10,DEGS1,EDN1,FAS,FOS,G0S2,GYS1,HADHB,HIF1A,HOXA10,IFI30,ISG15,KIF3B,MAT2A,MBP,MKI67,MT-ATP6,MT-CO2,MT-CYB,MT-ND1,MVD,NDUFS3,NR4A2,NR5A2,PFKFB3,PFKL,PIK3R1,POLD2,PTPRC,PTPRK,SBF1,SCD,SDC4,SDHB,SLC25A1,SNRPF,SOCS3,SPP1,TAF10,THBS1,TP53,VCAM1,ZBTB16	AHR,AKT1,CEBPA,CEBPB,CHUK,CREBBP,CTNNB1,FOXO1,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),PTEN,RELA,SP1,STAT1,TNF	
P2	 	IGF1	-1.888	growth factor	 	1.466	bias	0.421	-1.306	7.80E-06	ADIPOQ,AKR1C1/AKR1C2,APP,C1QA,CCND2,CCND3,CTSD,CYBB,CYR61,DDIT3,DMD,EDN1,EGR1,ESR2,FOS,FOSB,GAPDH,HIF1A,HMGA1,HMOX1,HSPA5,IGFBP4,INSR,ITGAV,JUN,LAMP1,LARP6,LEP,LHCGR,MAFG,MAPT,MBP,MIF,MKI67,NCAM1,NFE2L2,NUPR1,ODC1,PLA2G2A,PPP1R1B,PRNP,PTPRC,SCD,SNCG,SOCS3,SPP1,SRD5A1,THBS1,THRSP,TNFRSF12A,TP53,UBE2D2,UBE2G1,VCAM1	Ap1,CEBPA,CEBPB,EGR1,FGF2,FOS,FOXO1,IGF1,Ins1,JUN,LEP,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,RELA,SP1,STAT1,STAT5B,TNF	
P2	 	gentamicin C	 	chemical drug	Activated	3.000	bias	0.629	 	8.30E-06	ANXA1,ANXA2,ASNS,CAPN6,CD14,DMD,EFEMP2,FCGR2A,GAS5,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	cadmium chloride	 	chemical toxicant	Activated	2.063	bias	0.336	1.079	8.92E-06	ANXA5,ATF4,DDIT3,EEF1D,EIF3I,FOS,HMOX1,HSPA13,HSPA5,HSPB1,JUN,NFE2L2,TP53,TXN	AHR,BACH1,BDNF,CREB1,EGR1,ELK1,ERK,ESR1,ESR2,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,RELA,SP1,STAT1,beta-estradiol,cadmium chloride	
P2	 	ADRB	 	group	Inhibited	-2.435	bias	-0.251	-1.167	8.95E-06	AACS,ANXA5,ATF5,CD68,CRYAB,CXCL10,DDIT3,FAS,FOS,GCLM,GDF15,HMGCS1,HMOX1,JUN,KLF4,MSMO1,MVD,NQO1,NR4A1,NR4A2,RAN,SLC40A1,SLC7A11,SQSTM1,SRM,TRAF3	ADRB,AHR,Ap1,EGR1,ELK1,ERK,ESR1,FOS,IRF8,JUN,NFKB1,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1,TP53	
P2	 	brefeldin A	 	chemical - endogenous non-mammalian	 	0.266	 	0.033	0.149	9.75E-06	APP,DDIT3,GADD45B,HLA-A,HMOX1,HSPA5,HSPA9,KCND3,KLF4,LONP1,PRNP,SESN2,THBS1	ATF6,CEBPA,DDIT3,EIF2AK3,FOXO1,FOXO3,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,TP53,brefeldin A,lipopolysaccharide	
P2	 	vancomycin	 	biologic drug	Activated	3.289	bias	0.436	1.410	1.11E-05	AASS,ANXA1,ANXA2,ASNS,CAPN6,CD14,EFEMP2,FCGR2A,GAS5,HMOX1,PSMB10,RTN4,S100A11,SCD,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	MALSU1	2.154	other	Inhibited	-2.236	bias	0.721	 	1.16E-05	MT-CO1,MT-CO2,MT-ND1,MT-ND4,MT-ND6	 	
P2	 	histidinol	 	chemical - endogenous mammalian	 	1.400	bias	0.721	 	1.16E-05	ASNS,ATF4,EGR1,SLC7A1,SLC7A5	 	
P2	 	kainic acid	 	chemical toxicant	 	-0.308	bias	0.490	-2.665	1.17E-05	APOE,APOLD1,APP,ATF4,BTG2,CSF1R,CSRNP1,DCX,EGR1,FGF2,FOS,FOSB,GADD45B,HYOU1,JUN,NCAM1,NR4A1,NR4A2,ODC1,PER1,PIM3,RET,SPP1,SYP,TIMP1,TP53	Ap1,CEBPA,CREB1,CREBBP,CREM,CTNNB1,EGR1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,STAT1,kainic acid	
P2	 	cigarette smoke	 	chemical toxicant	 	1.848	bias	0.553	 	1.19E-05	AOX1,ATF4,CCT5,CXCL10,CYP3A5,CYR61,DDIT3,EGR1,FOS,FTL,G6PD,GCLM,GSTP1,HIF1A,HMOX1,HSPA5,HSPA9,JUN,KLF4,LEP,MT-ATP6,NFE2L2,NQO1,P2RX7,PGD,RAMP2,SLC1A4,SQSTM1,STAT1,TGFBR1,TIMP1,TP53,TREM2,TXNRD1	AHR,Ap1,BACH1,EGR1,ERK,FOS,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,cigarette smoke	
P2	 	IND S1	 	chemical - kinase inhibitor	 	0.333	 	-0.066	0.530	1.20E-05	ATP5D,C1QBP,CFL1,COPS8,ENO1,GLOD4,PGAM1,STIP1,TUBB	 	
P2	 	FGF2	2.228	growth factor	Activated	2.502	bias	0.366	0.131	1.26E-05	ADAMTS5,AKR1B1,ATF4,BTG2,CCND2,CCND3,CRYAB,CYR61,DAD1,DDIT3,EGR1,ENO1,ETV5,FAS,FGF2,FGFR2,FLNA,FOS,FTH1,GBP1,HIF1A,IGFBP4,JUN,MAPT,MBP,MIF,MKI67,NR4A1,NR4A2,ODC1,PDGFA,PDGFC,S100A8,SCD,SFRP1,SOCS3,SOX9,SPP1,SPRY4,SQSTM1,TGFB2,THBS1,TIMP1,TNFRSF12A,TOP2A,TP53,TPO,VCAM1	CEBPA,CEBPB,CTNNB1,EGR1,FGF2,FOXO1,FOXO3,HGF,IGF1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,Vegf	
P2	 	GnRH-A	 	chemical reagent	Inhibited	-2.808	 	0.160	-3.457	1.26E-05	AGPAT1,ANXA5,BTG2,CD53,CD68,CIDEA,EGR1,EIF2AK1,FOS,FOSB,GADD45B,JUN,KLF4,MAZ,NR4A1,PER1,RASD1	AHR,CREB1,CTNNB1,ELK1,ERK,FOS,FSH,GnRH-A,JUN,MAPK3,Mek,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53	
P2	 	E2F1	1.509	transcription regulator	Activated	2.570	bias	0.491	0.074	1.27E-05	ACTR1A,ADIPOQ,ALPL,CALM1 (includes others),CCND2,CCND3,CCT2,COPS8,CRYAB,CTSB,DDAH2,DUSP10,DUSP4,EGR1,EIF3I,EYA2,FAS,FGF2,FGFR2,FHL1,FOS,GM2A,GPS2,HIST1H2AC,HIST1H4H,HLTF,HMGA1,HNRNPK,HSPA8,KIT,KRT10,KRT14,LACTB,LEP,MAF,PIK3R1,PSAT1,PSMD2,RAN,RHOBTB2,RPS16,SLC3A2,SNRPC,SRPRA,STAM,THBS1,TOP2A,TP53,TRAF3,TRIM28,TXNL1,TXNRD1,UNG,VCAM1,VCP,YARS,ZNF672	Ap1,CEBPA,CEBPB,CREBBP,E2F1,EGR1,ELK1,ERK1/2,ESR1,FOS,FOXO1,Ins1,MYC,NFKBIA,NFkB (complex),PPARG,RB1,RELA,SP1,TP53,TP63,TP73	
P2	 	cyclosporin A	 	biologic drug	 	0.857	 	-0.218	2.433	1.27E-05	ADORA1,AKR1B1,ALAS1,ANXA1,ANXA2,APOB,APOE,APP,ASNS,BCAT1,CADM3,CAPN6,CD14,CD68,CD83,CXCL9,CYP3A5,EDN1,EFEMP2,EGR1,FAS,FCGR2A,FKBP5,FLNA,FOS,GAS5,HIF1A,HMOX1,HS2ST1,HSPA5,ITGAV,JUN,MAF,MDH2,MIF,NME1,NR4A1,ODC1,PKM,PRKACB,PSMB10,S100A11,SCD,SDCBP,SIAH2,SOD1,SPP1,SREBF2,SSR4,TGFBR1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TP53,TUBB,VCAM1,YWHAH	APOE,Ap1,CREB1,CTNNB1,EGR1,FOS,IL6,JUN,Jnk,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP73,cyclosporin A,doxorubicin	
P2	 	FMR1	1.381	translation regulator	 	-1.551	bias	-0.524	 	1.28E-05	ALDOA,APP,ATP5L,ATP6V1E1,CFL1,ENO1,GAPDH,MAP1B,PCLO,PPIA,RPSA,SYP,UQCRQ	 	
P2	 	bardoxolone	 	chemical drug	Activated	2.764	 	0.240	1.976	1.31E-05	CEBPG,DDIT3,EPHX1,FTH1,GCLM,HMOX1,HSPA9,MDH2,NQO1,SQSTM1,TXNRD1	 	
P2	 	GATA1	-3.566	transcription regulator	 	-1.055	bias	0.309	-2.370	1.32E-05	ACTN1,AIP,ALOX5AP,BTG2,BZW2,CCND2,CCND3,CCR1,CMA1,CPA3,CYBB,DMTN,EGR1,FCER1A,FHL1,FOSB,FYB,HNRNPAB,HSPA9,KIT,LYZ,MBP,MS4A2,NHP2,NR4A2,PLEK,PLXNA1,SLC19A1,SLC50A1,SOX6,SPTB,SRM,ST3GAL6	Ap1,FOS,GATA1,IL13,IRF8,JUN,MITF,NFKBIA,NFkB (complex),SPI1,STAT1,TP53	
P2	 	daidzein	 	chemical drug	 	0.688	 	0.206	-0.209	1.32E-05	ABCC3,ADIPOQ,AIF1,AKR1C3,BMP2K,C17orf75,CD4,DNASE1L3,DNPH1,FOSB,HLA-A,HLA-DQA1,ITGB2,LAPTM5,LCP2,MAL2,MMRN1,PIK3R1,TP53	ESR1,ESR2,JUN,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,STAT1,beta-estradiol,daidzein,estrogen receptor,ethanol,progesterone	
P2	 	okadaic acid	 	chemical toxicant	 	0.293	 	0.234	-0.712	1.32E-05	ANXA1,APP,CCND2,CCND3,CYBB,EGR1,FAM89B,FOS,FOSB,IL1RN,JUN,KLF4,KRT14,MAPT,ODC1,SAA1,SPP1,SQSTM1,THRSP	Ap1,CREBBP,ERK1/2,FOS,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,PRL,Pkc(s),RELA,SP1,STAT1,STAT5B,okadaic acid	
P2	 	NKX2-3	-4.280	transcription regulator	 	1.422	 	0.007	1.383	1.46E-05	ALPL,ANLN,ARHGDIB,ASNS,BCYRN1,CD68,CRYAB,CSRNP1,CXCL16,DANCR,EDN1,F2RL3,FGF2,GALNT15,GBP1,GDF15,HIST2H2AC,HNRNPA0,KLF4,LGMN,MMRN1,MYO5A,PIM3,PSAT1,RPS23,RPS29,SERPINE2,SHMT2,SLC40A1,SRPX2,STAT1,TXNDC12,TYMP,VCAM1	 	
P2	 	RTN4	2.293	other	 	-0.967	 	-0.033	-0.846	1.47E-05	ACTR1A,APP,ARHGDIA,CFL1,FGF1,GNG2,JUN,MAPRE3,MBP,NQO1,PEA15,RTN4,STAT1,YWHAG	Ap1,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,RTN4	
P2	 	mir-122	 	microrna	Inhibited	-4.352	bias	-0.639	 	1.57E-05	ACTR1A,ADGRB2,ALDOA,FKBP1A,G6PD,GIT1,GYS1,H1F0,KIF5B,LETM1,MAP1B,PKM,RCC2,SEPT9,SH3BGRL3,SLC1A5,SLC7A1,WARS,YARS	 	
P2	 	IND S7	 	chemical - kinase inhibitor	 	-0.632	bias	-0.257	0.182	1.63E-05	ATP5D,C1QBP,COPS8,ENO1,ERP29,GLOD4,PCK2,PGAM1,STIP1,TUBB	 	
P2	 	oleic acid	 	chemical - endogenous mammalian	 	-0.306	 	0.197	-1.179	1.71E-05	APOB,APOE,APP,ATF4,DDIT3,DEGS1,DGAT2,EDN1,FOS,GADD45B,GAPDH,HMOX1,HSPA5,NR4A1,PLIN1,PLIN2,PLIN5,SCD,THRSP,UCP2,VCAM1	ARNT,CEBPA,CEBPB,CREB1,D-glucose,DDIT3,FOXO1,HIF1A,Insulin,MYC,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SP1,SREBF1,fatty acid,oleic acid,palmitic acid	
P2	 	PI3K (family)	 	group	Activated	2.558	bias	0.365	1.040	1.72E-05	AKR1C1/AKR1C2,CCND3,CTSD,CXCL10,CXCL9,DDIT3,FOS,GCLM,HIF1A,HK1,HMOX1,HSPA5,LEP,NFE2L2,NQO1,PKM,SIAH2,TNFRSF10B	AHR,AKT1,Ap1,CREBBP,EGR1,ELK1,ESR1,FOXO1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (family),RELA,SP1,STAT1,TNF,TP53	
P2	 	bortezomib	 	chemical drug	Activated	2.503	 	0.106	1.912	1.75E-05	ALPL,ATF4,CCND2,CRYAB,CXCL10,DCAF12,DDIT3,DMD,ERN1,FANCE,FAS,GADD45B,GDF15,HSPA5,HSPA7,IGKC,KIT,ODC1,PSMA3,PSMA4,PSMA6,PSMB2,PSMB4,PSMB6,PSMB7,PSMC4,PSMD14,PSMD2,PSMD7,PSMD8,SAA1,TNFRSF10B,TP53,UCHL1,VCAM1	AHR,Ap1,CREBBP,EGR1,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53,bortezomib	
P2	 	Cdc42	 	enzyme	Activated	2.530	 	0.180	1.960	1.81E-05	ATP6V1A,CTSA,CTSB,CTSD,CTSS,FAS,FGF2,FLNA,LAMP1,LAMP2,NPC2	 	
P2	 	ERN1	3.149	kinase	Activated	2.492	bias	0.400	0.645	1.96E-05	ATF4,DDIT3,DGAT2,DNAJB11,EDEM1,FAS,GOT1,HSPA5,JUN,MVD,NARS,PLIN2,SCD,SEC61A1,SEL1L,SLC7A1,SPTLC3,SRP19,SRPRA,TBCB,TMED3,TNFRSF10B,WARS	ATF6,Ap1,EGR1,ERN1,FOS,FOXO1,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,XBP1	
P2	 	PPARGC1A	1.316	transcription regulator	 	1.782	bias	0.563	 	1.97E-05	ADIPOQ,AK1,ALAS1,ATP5J2,CALM1 (includes others),CD68,CDC42EP1,CIDEA,COX7B,CYCS,CYP3A5,IL1RN,MBP,MDH2,ME1,MT-CO1,MT-CO2,NDUFS8,NR5A2,PCK2,PGAM1,PLIN2,PLIN5,PRDX5,SCD,SCO2,SESN2,SOCS3,SOD1,SYT2,TNFRSF12A,TP53,TRIB3,UCP2	ATF4,CEBPA,CEBPB,DDIT3,E2F1,EGR1,FOXO1,NFkB (complex),NR1I2,NRF1,PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SREBF1,fatty acid,palmitic acid	
P2	 	HMOX1	3.096	enzyme	 	-0.161	 	-0.047	0.016	1.99E-05	ADIPOQ,CD14,CXCL10,CXCL9,ENG,FGF1,FOS,G6PD,HMOX1,IL1RN,MAPT,MSR1,NFE2L2,NQO1,NR4A2,SLC25A5,TGFB2,THBS1,TP53,TYMP,VCAM1	AHR,Ap1,CREBBP,EGR1,ERK,FOS,HMOX1,JUN,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,SREBF1,STAT1,cholesterol	
P2	 	PRKCA	1.005	kinase	 	1.924	bias	0.382	0.565	1.99E-05	APP,ARHGDIB,CSTA,CTSB,CYBB,CYCS,EGR1,FOS,GBA,GDF15,HS2ST1,JUN,NQO1,PEG10,PHLDA2,S100A8,SDCBP,SZRD1,TGFB2,TP53,VCAM1	AHR,Ap1,CREBBP,EGR1,FOS,IRF8,JUN,Jnk,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,PRKCA,PTPN11,RELA,SPI1,STAT1,TP53,TP73,doxorubicin	
P2	 	calmidazolium	 	chemical drug	 	-0.928	bias	-0.288	-0.233	2.44E-05	EGR1,FOS,NCAM1,RSPO1,SOX9,VCAM1	Ap1,CEBPB,CTNNB1,EGF,EGR1,FOS,JUN,MYC,Mapk,NFKB1,NFkB (complex),PPARG,RELA,SRC,STAT1,calmidazolium,cyclic AMP	
P2	 	AHR	1.201	ligand-dependent nuclear receptor	 	-0.124	 	0.059	-0.439	2.61E-05	ABCB6,ACTN1,ADAMTS5,ALDH2,APP,ATP2B1,BTG2,BZW2,CBR1,CCND3,CHST2,COL16A1,COL5A2,CTSD,CXCL10,DMXL2,DUSP6,EDN1,FAS,FGFR2,FOS,GHITM,GOT1,HIF1A,HSPA5,HSPH1,ITGA7,JUN,KIT,NFE2L2,NMT2,NNMT,NQO1,POMP,SAA1,SHB,SIM1,SLC1A4,SNTA1,SOD1,SPP1,TGFB2,THBS1,TP53,TXN	AHR,Ap1,CEBPA,CREBBP,EGR1,ELK1,ESR1,IL6,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TGFB1,TP53	
P2	 	RXRA	1.254	ligand-dependent nuclear receptor	 	-0.392	bias	0.312	-1.633	2.77E-05	ABCC3,ACSL3,AKR1C1/AKR1C2,APOE,APP,ASNS,CCND3,CIDEA,CRYAB,CXCL10,CYP3A5,CYP4A11,ENG,EPHX1,FOS,FTL,HADHB,HIF1A,HMOX1,MBP,NDUFC2,NME1,NR1D1,NR5A2,PCK2,PLA2G2A,PLIN1,PLTP,RET,SCD,SORBS1,SPP1,SREBF2,TCF7,TGFB2,TNFRSF10B,TPP1,TXN	CEBPA,FOS,FOXO1,HTT,JUN,L-triiodothyronine,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SREBF1,STAT1,THRB,alitretinoin	
P2	 	PRNP	2.761	other	 	0.945	 	0.048	0.788	2.86E-05	APOE,APP,ATF4,CTSD,DAB2,EGR1,HSPA5,HSPA8,HSPA9,HSPB1,LAMP2,PRNP,SOX9,SYP,TCF7,TP53	AHR,APP,CEBPA,CEBPB,CREBBP,FOS,FOXO1,HIF1A,IGF1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PRNP,RELA,SP1,STAT1,TP53,TP63,TP73,cyclic AMP	
P2	 	thioctic acid	 	chemical drug	 	-0.644	bias	-0.309	0.359	2.93E-05	ABCC1,AGER,FOS,HMOX1,JUN,LEP,NFE2L2,NQO1,PARK7,SLC7A11,SOD1,TP53,UCP2,VCAM1	AHR,Ap1,CEBPA,EGR1,ERK,FOS,FOXO1,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,RXRA,SP1,STAT1,TNF,thioctic acid	
P2	 	sulforafan	 	chemical drug	Activated	2.100	 	-0.007	2.128	2.94E-05	AKR1B1,AKR1C1/AKR1C2,AOX1,ENTPD5,EPHX1,FAS,FOS,FTL,GCLM,GSTP1,HIF1A,HMOX1,KEAP1,NFE2L2,NQO1,PTPRC,SOCS3,SOD1,TALDO1,TNFRSF10B,TP53,TXNRD1,VCAM1	Ap1,BACH1,EGR1,EP300,FOS,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PML,RELA,SP1,STAT1,TNF,sulforafan	
P2	 	acetaminophen	 	chemical drug	Activated	2.668	bias	0.272	1.372	3.16E-05	ABCC1,ABCC3,ACTG1,BTG2,CA3,CCR1,CES1,CXCL10,CYP3A5,CYP4A11,DDIT3,FAS,GLUL,GSTP1,HIF1A,HMGCS1,HMOX1,HSPA5,JUN,ME1,NQO1,ODC1,SOCS3,TUBB,TXN,VCAM1	Ap1,BACH1,CEBPA,EGR1,FOS,IL1B,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53,acetaminophen	
P2	 	nitric oxide	 	chemical - endogenous mammalian	 	1.481	bias	0.257	0.227	3.27E-05	APP,CXCL10,DDIT3,DUSP6,EDN1,EGR1,FAS,FOS,FTH1,GCLM,GSTP1,HMOX1,JUN,KRT14,MKI67,MT-CO1,NCAM1,NFE2L2,NQO1,ODC1,PRDX5,SOD1,SPP1,SQSTM1,THBS1,TP53,TXNRD1	AHR,Ap1,EGR1,ERK,FOS,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TNF,TP53,hydrogen peroxide,nitric oxide	
P2	 	VHL	-1.163	transcription regulator	 	1.803	bias	-0.281	2.529	3.36E-05	AHCYL1,AIF1,ATF4,CFL1,DAB2,FTH1,FTL,GBE1,GLO1,HIF1A,HMOX1,MAF,MIF,MYL12B,PFKFB3,POLRMT,PPIL1,PREB,SLC1A3,SLC40A1,TMED3,TP53,UQCRQ	ARNT,CREBBP,EP300,EPAS1,HIF1A,MYC,NFkB (complex),PPARG,RNA polymerase II,TP53,VHL,estrogen receptor	
P2	 	10E,12Z-octadecadienoic acid	 	chemical - endogenous mammalian	Activated	2.377	 	0.162	1.822	3.62E-05	ADIPOQ,ATF4,CA3,DDIT3,GDF15,ME1,NR4A1,NR4A2,PLIN1,PLIN2,SCD,SORBS1,SOX6,TRIB3,UCP2	10E,12Z-octadecadienoic acid,ATF6,CEBPA,CEBPB,DDIT3,FOXO1,JUN,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SREBF1,fatty acid,oleic acid,palmitic acid	
P2	 	carbon tetrachloride	 	chemical toxicant	 	1.794	bias	0.457	-0.633	3.68E-05	ABCC1,AOX1,APOB,APOE,ASS1,CA3,CCR1,CXCL10,DDIT3,FKBP1A,FOS,GADD45B,GDF15,GSTP1,HDGF,HMOX1,HSPB1,ITGA8,JUN,ME1,NQO1,NR4A1,ODC1,PDGFA,PDGFC,PRNP,SPP1,TGFB2,TGFBR1,TIMP1,TNFRSF12A,VCAM1	Ap1,CEBPB,EGR1,FOS,IFNG,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,carbon tetrachloride	
P2	 	THRB	-1.479	ligand-dependent nuclear receptor	 	1.074	 	0.212	0.135	3.76E-05	ATP5L,BTG2,CCND2,CCND3,CSNK1A1,CTBP1,CTSD,CXCL10,DAD1,ENG,FOS,HIF1A,JUN,LYZ,MBP,ME1,NME1,NR4A1,NR5A2,PER1,PGD,PLA2G2A,PLIN1,POR,SFRP1,SFRP4,SREBF2,TCEA3,THRSP,WNT5B	AKT1,Ap1,FOS,FOXO1,HTT,JUN,L-triiodothyronine,MYC,NFE2L2,NFkB (complex),PI3K (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SRC,STAT1,THRB	
P2	 	IL10	-1.301	cytokine	 	0.557	 	0.078	0.066	4.12E-05	AGER,ALOX5AP,CCND2,CCND3,CCR1,CD14,CD163L1,CD2,CD209,CD28,CD68,CD83,CSF1R,CTSB,CTSS,CXCL10,CXCL9,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FKBP5,FOS,HLA-G,HMOX1,IGFBP4,IL10RA,IL17RA,IL1RN,IRAK1,JUN,LAMP3,MAF,MS4A2,MSR1,PIK3CG,PLA2G2A,PTX3,S100A8,SHB,SLC1A3,SOCS3,STAT1,TIMP1,TLR8,TUBB4B,VCAM1	CEBPA,CEBPB,CREBBP,IFNG,IL10,IL1B,IL4,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	IL4	-2.321	cytokine	Activated	2.176	bias	0.421	-0.951	4.36E-05	ACP2,ADRM1,ALAS1,ALDH2,ALG3,ALOX5AP,ANXA2,APOE,APOLD1,APRT,ASS1,BIN1,CAPG,CARM1,CBX3,CCND2,CCND3,CD14,CD163L1,CD2,CD209,CD83,CLCN3,CLIP1,CTNNA1,CXCL10,CXCL16,CXCL9,DSG1,EIF3G,EPHX1,F13A1,FAM162A,FAS,FBL,FCER1G,FCGR2A,FCGR3A/FCGR3B,FKBP5,FOS,FOSB,GBE1,IFI30,IGFBP4,IGHG3,IL10RA,IL1RN,ISG15,ITGAV,ITGB2,JUN,KIT,KRT10,LAMP2,LDLRAD3,LFNG,LGALS2,MAF,MS4A2,MSR1,ORC5,PFKL,PLIN2,PMVK,PREPL,PRNP,PSMA6,PSMB10,PSME1,PSMG1,S100A8,SIRPA,SLC7A2,SOCS3,SPP1,SQSTM1,SRM,STAB1,STAT1,SYNGR2,TCF7,TIMP1,TOP3B,TP53,TRAF3,TREM2,VCAM1	CEBPB,CREBBP,IFNG,IL10,IL4,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	HSF2	-1.088	transcription regulator	Activated	2.621	bias	0.378	1.632	4.49E-05	CCT2,CCT5,HIF1A,HSPA4,HSPA7,HSPB1,HSPH1,JUN,LHCGR,TXN	 	
P2	 	NFE2L1	1.906	transcription regulator	 	1.913	bias	0.524	 	4.49E-05	CYP4A11,GCLM,GSTP1,HMOX1,LEP,NQO1,PSMA6,PSMB2,PSMB6,PSMB7	 	
P2	 	MAFK	-1.108	transcription regulator	 	0.712	bias	0.360	-0.138	4.52E-05	ABCC3,GCLM,GSTP1,HMBS,HMOX1,NQO1,TXN,TXNRD1	Ap1,BACH1,JUN,MAFK,NFE2L2,NFkB (complex),RELA	
P2	 	mibolerone	 	chemical drug	Activated	2.970	 	0.229	1.881	4.65E-05	ALCAM,CD74,CLTB,DAD1,DNAJB11,ERP29,FHL1,FKBP1A,FKBP5,HLA-DQA1,HMGCS1,HSPA5,HYOU1,JUN,MAT2A,NME1,NME2,PPIA,PRELP,SLC25A5,SRM,TMED3,TOP2A,UCP2	 	
P2	 	Pkc(s)	 	group	 	-0.915	bias	0.402	-2.780	4.92E-05	APP,CCND3,CD4,CLDN1,CTSB,CYBB,CYR61,DDIT3,EDN1,EGR1,ERN1,FAS,FGF2,FOS,GADD45B,HIF1A,HMOX1,HOXA7,HSPA5,JUN,MSR1,NQO1,NR1D1,NR4A1,NR4A2,PER1,S100A1,S100A8,SLC1A2,SPP1,STC2,VCAM1	AHR,Ap1,CREBBP,EGR1,FOS,JUN,Jnk,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,Pkc(s),RELA,SP1,STAT1,TNF	
P2	 	CLCN5	1.189	ion channel	 	0.242	 	-0.144	0.587	5.04E-05	CA3,CTSB,CUBN,MKI67,SOD1,TXN	 	
P2	 	halofuginone	 	chemical drug	 	 	 	 	 	5.25E-05	AACS,CPA3,CYGB,EGR1,EPHX1,FCER1A,GDE1,GOT1,HK1,HSPA4,ITGA7,MS4A2,NFE2L2,NLGN1,NUPR1,PCSK6,PKM,POR,PPT1,PRELP,SCPEP1,SPP1,STEAP3,TIMP1	 	
P2	 	IL2	-3.082	cytokine	Activated	3.624	bias	0.448	0.835	5.26E-05	ABCC1,ARHGDIA,ATF5,CCND2,CCND3,CD160,CD2,CD28,CD83,CSF1R,CSRNP1,CTPS1,CXCL10,CYCS,DAP,DAPK2,DUSP4,DUSP6,EDN1,FAS,FCER1G,FCGR3A/FCGR3B,FGF2,FGFR2,FOS,GADD45B,GAPDH,GARS,GDF15,GNL3,HSPA5,IL10RA,IL2RG,JUN,KIT,LAPTM5,LCP2,MAF,MAPKAPK2,NDUFA12,NME1,PDGFC,PEA15,PHB2,PHLDA2,PIK3R3,PTPRC,PTPRJ,SOCS3,SPP1,SPRED1,STAM,STIP1,TIMP1,TNFRSF10B,TNFRSF12A,TP53,TP53RK,TRIB3,VDAC1,YARS	Ap1,CREBBP,EGR1,ERK1/2,FOS,IL10,IL2,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	L-triiodothyronine	 	chemical - endogenous mammalian	 	1.948	 	0.233	0.453	5.49E-05	ADAMTS5,ADIPOQ,APOB,APOC1,APP,ARSA,ATIC,CBR1,CYP4A11,DVL1,EDN1,EGR1,ENG,FAS,FOS,G6PD,HIF1A,HINT1,IGFBP4,ITGA7,KRT6A,LEP,LHCGR,LYZ,MBP,ME1,MT-CO2,MT-CO3,MT-ND4,NME1,NR1D1,NR4A1,NR5A2,ODC1,PER1,PLA2G2A,POR,RET,SCD,SLC9A1,SORBS1,SRM,THRSP,TP53,UBA1,UCP2	AGT,CREB1,FOXO1,HIF1A,Insulin,JUN,L-triiodothyronine,LEP,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,STAT1,STAT5B,THRB	
P2	 	2-deoxyglucose	 	chemical drug	 	0.173	 	0.111	-0.187	5.55E-05	APP,ATF4,DDIT3,FOS,GOT1,HIF1A,HSPA5,INSR,JUN,LEP,ODC1,SPP1,TNFRSF10B,TP53	2-deoxyglucose,Ap1,CEBPA,CEBPB,EGR1,FOS,FOXO1,FOXO3,HIF1A,IGF1,INS,JUN,Jnk,MYC,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,STAT5B,TP53	
P2	 	irbesartan	 	chemical drug	 	-1.117	bias	-0.360	-0.056	5.77E-05	ADIPOQ,AGER,FHL1,FOS,HRAS,INSR,ITGAV,LEP,VCAM1	Ap1,FOS,FOXO1,HIF1A,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,PTGS2,RELA,SP1,STAT1,TP53,irbesartan,reactive oxygen species	
P2	 	rosiglitazone	 	chemical drug	 	1.124	bias	0.261	-0.675	6.14E-05	ADIPOQ,APOC1,APOE,C1QA,C1QB,C1QC,CD68,CIDEA,CXCL10,CXCL9,CYCS,DGAT2,FGF1,FOS,GAPDH,GBP1,GIPR,GOT1,GYS2,HADHB,HLA-DRA,HMOX1,HSPA5,HSPA9,IL1RN,INSR,KLF4,LEP,LFNG,MAT2A,MDH2,MSR1,NR1D1,PCCA,PEA15,PIK3R1,PLIN1,PLIN2,PLIN5,PLTP,PPP2R1B,S100A8,SCD,SEMA3C,SLC9A1,SOCS3,SOD1,SORBS1,SPON2,THBS1,TIMP1,TPM3,UCP2	ADIPOQ,CEBPA,CEBPB,CTNNB1,DDIT3,EGR1,FOXO1,JUN,LEP,NFKB1,NFkB (complex),PPARA,PPARG,RELA,RXRA,SREBF1,STAT5B,palmitic acid,rosiglitazone	
P2	 	melatonin	 	chemical - endogenous mammalian	 	1.601	 	-0.038	1.758	6.24E-05	CXCL10,CYCS,DDAH2,EDN1,FAS,FOS,GJB2,HIF1A,HMOX1,HSPA9,INSR,LEP,NCAM1,NFE2L2,NQO1,SOD1,SOX9,SPP1,SQSTM1,STS,TP53	ATF4,Ap1,E2F1,EGR1,FOXO1,HIF1A,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR1I2,P38 MAPK,PI3K (complex),PPARG,RELA,SP1,STAT1,TNF,melatonin,reactive oxygen species	
P2	 	miR-122-5p (miRNAs w/seed GGAGUGU)	 	mature microrna	Inhibited	-2.658	bias	-0.721	 	6.46E-05	AACS,ADAM17,ALDOA,BCKDK,CERS6,GYS1,NCAM1,PKM,PSME1,SLC35A4,SLC7A1,SLC7A11,TMED3,TTYH3,XPO6	 	
P2	 	triamterene	 	chemical drug	Activated	3.363	bias	0.655	 	6.46E-05	ANXA1,ANXA2,ASNS,CAPN6,CD14,EFEMP2,FCGR2A,GAS5,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	Collagen(s)	 	complex	Activated	2.191	 	0.224	1.456	6.58E-05	ATF4,C3AR1,CD63,CD68,CYR61,DDIT3,EDEM1,IARS,LAMP1,LAMP2,PSAT1,THBS1	 	
P2	 	TCF7L2	-1.059	transcription regulator	Activated	4.743	bias	0.628	 	6.80E-05	ACOT4,ACSL3,ADO,ALDH3A2,ANLN,BIN1,CCND2,CD4,CERS2,CTNNA1,DEGS1,ENTPD5,EVI2B,FAM91A1,FGFR2,FKBP1A,FTH1,GCLM,GLUL,GSS,GYS2,HSPA2,KIF5B,LAMP1,MAP4K4,MBP,ME1,MOBP,MTMR2,NPC2,PIM3,RAP2A,RHOG,SLC12A2,SLC1A2,SRD5A1,STK39,TAF10,TMEM123,TMEM2,TNS1,UBE2G1	CEBPA,CTNNB1,JUN,NFkB (complex),TCF,TCF7L2,TP53	
P2	 	rifampin	 	chemical drug	 	1.809	bias	0.522	 	6.89E-05	ABCC1,ABCC3,AKR1C1/AKR1C2,ALAS1,ATP2B1,C9orf72,CARS,CD14,CES1,CES2,CFL1,CRYAB,CXCL10,CYP3A5,CYP4A11,CYP4B1,GSTP1,ME1,PCIF1,PCK2,PNRC2,SPP1,TBC1D9,TRIM31,TSN	FOXO1,NR1I2,NRF1,PPARA,PPARD,PPARG,PPARGC1A,rifampin	
P2	 	NRG1	-19.349	growth factor	 	1.366	bias	0.321	0.063	6.90E-05	ACTN1,ARHGEF2,ARPC4,ATF4,BIN1,CCND2,CCND3,CDC42EP1,CYR61,DAD1,DDIT3,DUSP4,DUSP6,EDN1,EGR1,ESR2,FGF1,FOS,FOSB,GPS2,HIF1A,HMGA1,HMOX1,HNRNPK,ITGAV,LMO4,MBP,MSR1,NR4A1,PCCB,PDGFA,PFKFB1,TGFBR1	Ap1,CREBBP,CTNNB1,EGF,EGR1,ERBB2,ERK1/2,FOS,FOXO1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NRG1,Pkc(s),RELA,SP1,STAT1,TP53,TSC2	
P2	 	MEL T1	 	chemical - kinase inhibitor	 	1.134	 	0.090	0.896	6.95E-05	ATP5D,C1QBP,CFL1,COPS8,ENO1,GLOD4,PGAM1	 	
P2	 	fluticasone	 	chemical drug	 	-1.634	 	0.017	-1.726	7.06E-05	C1QB,CD4,CD74,CD83,CES1,CXCL10,CXCL9,FKBP5,GADD45B,GJB2,HLA-DQA1,HLA-DRA,HTRA1,IL1RN,PLIN2,RARRES3,RNASE1,S100A8,SDC4,SLC1A3,SLC2A5,SPP1,STAT1,THBS1,TIMP1,TPM3,VSIG4,WARS	AHR,CREBBP,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,RELA,STAT1,TP53,fluticasone	
P2	 	PI3K (complex)	 	complex	Activated	2.946	bias	0.486	0.320	7.10E-05	ADAM12,ATF4,CCND2,CCND3,CCR1,CD2,CTSD,CXCL10,CYBB,DDIT3,FOS,G6PD,GCLM,GSTP1,HIF1A,HK1,HMOX1,IL1RN,ITGB2,JUN,LEP,LHCGR,MT-CO1,NFE2L2,NME1,NQO1,NR4A2,NUPR1,PIK3CG,PPP1R1B,SLC9A1,SNCG,SOCS3,SOX9,SPP1,THBS1,TP53,TYMP,VCAM1	Ap1,EGR1,FOS,HMOX1,JUN,LY294002,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF,nitric oxide	
P2	 	methotrexate	 	chemical drug	 	1.308	 	0.110	0.744	7.53E-05	ACTG1,AGER,ALDOA,ASS1,BTG2,C1QB,C6,CD28,CES1,CFH,CTSS,CXCL10,CYCS,CYP4A11,DGAT2,DUSP10,FAS,GAPDH,HADHB,HMGCS1,HMOX1,INSR,MAPKAPK2,MECR,NQO1,NR4A2,PPIA,RAC1,S100A11,SCD,SOCS3,SOD1,SPP1,TP53,VCAM1	Ap1,CEBPA,EGR1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,methotrexate,nitric oxide	
P2	 	phorbol myristate acetate	 	chemical drug	Activated	4.126	bias	0.356	0.709	7.62E-05	ACSM5,ADAM17,AGER,AHSA1,ALAS1,ANXA1,APP,APRT,ARID3B,B3GNT5,BTG2,CAPG,CCND2,CCND3,CD14,CD209,CD28,CD4,CD52,CD68,CES1,CLDN1,CSF1R,CSTA,CTSB,CTSD,CXCL10,CYBB,CYR61,DAB2,DSG1,EDF1,EEF1D,EGR1,EIF5A,ESR2,FAS,FCER1G,FGF2,FKBP5,FOS,FOSB,FTH1,GDF15,GSTP1,HIF1A,HIST1H4C,HLA-DRA,HMBS,HMGA1,HNRNPK,HOXA7,HRAS,HSPA4,HSPA5,IL1RN,IL2RG,IRAK1,ISG15,ITGB2,JUN,KIT,KLF4,KRT10,LARP4,LYZ,MAF,MAPK9,MSR1,MT-CO1,NME2,NPR3,NQO1,NR4A1,NR4A2,ODC1,PDE1C,PDGFA,PEA15,PER1,PI3,PKM,PRNP,PTGFR,PTPRC,PTPRJ,RPL19,S100A8,SLC12A2,SLC7A1,SLC7A11,SMPD1,SNCG,SOCS3,SOD1,SPP1,STAT1,STK40,THBS1,THRSP,TIMP1,TLR8,TNFRSF12A,TP53,TPM3,TPO,TRAF3,TYMP,VCAM1,VSIG4	Ap1,CEBPA,CEBPB,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,TNF,phorbol myristate acetate	
P2	 	LIPE	1.190	enzyme	 	-0.555	 	0.164	-0.918	7.69E-05	ADIPOQ,CD74,EDN1,EGR1,FKBP5,FOS,G0S2,GAPDH,HLA-DQA1,MAPKAPK2,MAPT,MSR1,NR4A1,PER1,PFKFB1,PLIN2,POLR2K,SCD,SDC4,SOX18,THRSP,YWHAG	AKT1,CEBPA,CEBPB,FOS,FOXO1,Ins1,JUN,LDL,LEP,LIPE,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,SP1,SREBF1,STAT1,STAT5B,fatty acid	
P2	 	FOXO1	-1.874	transcription regulator	Activated	2.053	bias	0.468	-0.641	7.86E-05	ADIPOQ,AFF3,AIFM2,ALAS1,ANLN,ATP5J,ATP6V0B,BANK1,CIDEA,CXCL10,CYCS,DCX,EDN1,EGR1,FAS,FOS,FOSB,GADD45B,HMOX1,HSPA5,HYOU1,IL17RA,INSR,IRF5,ITGAV,JUN,KLF4,LAMP2,LEP,LHCGR,ME1,MRPS2,MRPS30,MVD,NDUFA12,NDUFA4,NDUFA9,PCK2,PSMB6,RAB7A,SCD,THBS1,TP53,TRIB3,VCAM1	AKT1,CEBPA,CREBBP,EGR1,ERK1/2,FOS,FOXO1,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RB1,RELA,RXRA,SP1,STAT1,TP53	
P2	 	captopril	 	chemical drug	Activated	2.569	 	0.175	1.873	8.41E-05	ANXA1,ASNS,CAPN6,CSRP2,EFEMP2,FCGR2A,GAS5,HMOX1,IL1RN,S100A11,SPP1,TGFB2,THBS4,TIMP1,TMSB10/TMSB4X,TNFRSF12A	AGT,AKT1,FOXO1,HIF1A,JUN,NFKBIA,NFkB (complex),RELA,SP1,STAT1,captopril	
P2	 	let-7a-5p (and other miRNAs w/seed GAGGUAG)	 	mature microrna	Inhibited	-4.006	bias	-0.721	 	8.62E-05	ATP6V1F,BMP2K,CAPG,CCND2,COMMD9,DAD1,GYS1,HMGA1,HMOX1,HRAS,HYOU1,IPO4,MRPS24,MTPN,POLD2,RHOG,SCD,SEPT3,SIGMAR1,SLC1A4,SLC25A1,SLC38A1,TGFBR1,THBS1,TMEM2	 	
P2	 	glutamine	 	chemical - endogenous mammalian	Inhibited	-2.527	 	-0.154	-2.027	8.77E-05	AARS,AKR1C1/AKR1C2,ASNS,ASS1,ATF4,ATF5,BCAT1,CARS,DDIT3,FOS,HK1,HSPA5,NR4A1,OAZ1,PCK2,TP53,WARS	ATF4,Ap1,DDIT3,EGR1,FOS,FOXO1,FOXO3,INS,JUN,Jnk,MYC,NFE2L2,NFKB1,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,STAT5B,glutamine	
P2	 	CDK5R1	-4.950	kinase	 	1.000	 	0.144	0.712	9.46E-05	CD14,CD63,FOS,MAPT,PPP1R1B,SOX6	CDK5,CDK5R1,JUN	
P2	 	azetidyl-2-carboxylic acid	 	chemical reagent	Activated	2.407	bias	0.721	 	9.46E-05	ASNS,DDIT3,EDEM1,HSPA5,HSPA8,HSPA9	Ap1,NCK1,azetidyl-2-carboxylic acid	
P2	 	selenomethylselenocysteine	 	chemical - endogenous mammalian	 	0.113	bias	-0.393	1.218	1.01E-04	ABCC1,CES1,CYP3A5,EGR1,JUN,PSME1,RPS12,SOD1	 	
P2	 	Esrra	 	transcription regulator	 	0.955	 	0.144	0.404	1.03E-04	ALDOA,ATP5G1,ATP5J,ATP5J2,COX7A2L,CRAT,CYCS,ENO1,GYS1,NDUFA2,NDUFS3,PCK2,PFKL,SDHB,SOX9,SPP1,UQCR11	Esrra,FOXO1,NRF1,PPARA,PPARD,PPARG,PPARGC1A	
P2	 	allopurinol	 	chemical drug	Activated	2.668	bias	0.446	0.828	1.03E-04	ANXA1,ANXA2,ASNS,CAPN6,CD14,CXCL10,EFEMP2,FCGR2A,GAS5,HMOX1,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	AHR,CREBBP,ERK,FOS,IRF8,JUN,MYC,NFKBIA,NFkB (complex),RELA,SP1,SRC,STAT1,allopurinol	
P2	 	CSF2	-1.733	cytokine	Activated	3.874	bias	0.557	 	1.07E-04	ALOX5AP,ANLN,ANXA1,CCND3,CCR1,CD14,CD209,CD28,CD63,CD74,CD83,CFH,CHST11,COL8A1,CSF1R,CXCL10,CYBB,DDIT3,DUSP6,EDN1,EFEMP2,EGR1,FAS,FOLR2,FOS,GCLM,GDF15,HCAR2,HLA-DQB1,HSPH1,IL1RN,IRF5,LAMP2,LCP1,LEP,MAT2A,MKI67,NACA,NR4A1,NR4A2,ODC1,PIK3CG,PIM3,PRNP,QSOX1,RRM2B,SLC1A5,SNTB1,SOCS3,SPP1,SQSTM1,STEAP3,THBS1,TOP2A,TP53	Ap1,CEBPB,CSF2,IFNG,IL6,IRF8,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF	
P2	 	triclosan	 	chemical drug	 	1.633	bias	0.529	 	1.11E-04	CYBB,FOS,HMOX1,JUN,MBD3,NQO1,TIMP1	ESR1,ESR2,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,beta-estradiol,estrogen receptor,progesterone,triclosan	
P2	 	fenamic acid	 	chemical reagent	Activated	3.382	bias	0.616	 	1.11E-04	ANXA1,ANXA2,ASNS,CAPN6,CD14,EFEMP2,FCGR2A,GAS5,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	Immunoglobulin	 	complex	 	-0.499	 	-0.016	-0.413	1.11E-04	AGER,APP,C3AR1,CCND2,CCND3,CD28,CD83,CRISPLD2,CSF1R,CXCL10,CXCL9,EGR1,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FOS,FOSB,HMOX1,IFI30,IL10RA,IRF5,KLF4,MAPT,PDGFA,PDIA6,S100A8,SIRPA,STAB1,TIMP1,TLR8,TYMP,VCAM1,ZBTB16	CEBPB,CREBBP,IFNG,IL10,IL4,IRF8,Immunoglobulin,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	TCR	 	complex	 	1.226	bias	0.475	-1.107	1.13E-04	BCAT1,BIN1,CCND3,CCR1,CD28,CD4,CTSB,CXCL10,CXCL9,EGR1,ETV5,FAS,FLNA,FOS,GADD45B,HIF1A,HSPA5,ISG15,JUN,LAMP1,LCP2,MAF,MAPK9,NHP2,NME1,NR4A1,ODC1,P2RX7,PIK3R1,PIK3R3,PRELID1,PRKACB,PTPRC,SDCBP,SIAH2,SOCS3,SPP1,STAT1,TNFRSF12A,TRAF3	Ap1,BCL6,CD3,CREBBP,IL2,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,TCF3,TCR	
P2	 	LEP	-3.989	growth factor	 	-0.947	bias	0.269	-2.674	1.21E-04	ABCC3,ADIPOQ,AKR1C1/AKR1C2,APP,ASS1,CA3,CD14,CD63,CD68,CIDEA,CXCL10,CYBB,CYP3A5,CYP4A11,CYR61,DUSP6,EDN1,EGR1,ESR2,FAS,FGFR2,FOS,GAPDH,HSPA5,IL1RN,JUN,KIF3B,LEP,MBP,MSMO1,MT-CO3,MT-CYB,MT-ND1,MT-ND4,NPY1R,PLIN1,PLIN2,PPP1CA,RAC1,SCD,SLC25A5,SMPD1,SOCS3,SOD1,SPP1,SREBF2,THBS1,THRSP,TIMP1,TP53,TSPO,UCP2,VCAM1	AKT1,CEBPA,CEBPB,CREB1,FOXO1,IGF1,IL6,Insulin,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,TNF	
P2	 	butyric acid	 	chemical - endogenous mammalian	 	0.501	 	0.073	0.046	1.21E-04	ACP2,ADCY1,ALPK2,ANXA1,ANXA2,ANXA5,CALM1 (includes others),CCND2,CCR1,CD83,CLCN3,CLDN1,COL5A2,CPA3,CYCS,CYP4A11,DTYMK,FOS,FTH1,G0S2,GAA,GRN,GSTP1,H2AFZ,HADHB,HDGF,HIST1H1C,HK1,HLA-DRA,IFI30,KIT,KLF4,LEP,MKI67,MPP3,MT-CO2,NME1,NR4A1,PFKL,PLCB2,PSAP,SEC61B,SLC1A2,SMPD1,SOCS3,SOX9,SPP1,THBS4,TIMP1,TNFRSF10B,TOP2A,TP53,UQCRQ	Ap1,CEBPA,EGR1,FOS,JUN,Jnk,LY294002,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TGFB1,TNF,butyric acid	
P2	 	nonylphenol	 	chemical toxicant	 	1.508	bias	0.580	 	1.24E-04	ADIPOQ,ALAS1,ALDH5A1,APOB,ATP6AP1,CXCL10,CYP3A5,FAS,LCP2,RPN2,SLC1A5	NR1I2,nonylphenol	
P2	 	EPAS1	-1.012	transcription regulator	 	1.432	bias	0.558	 	1.25E-04	C1QA,CLDN1,DDIT3,EDN1,EIF5A,ENO1,FHL1,FOS,GADD45B,GBE1,GYS2,HIF1A,HIST1H1C,HIST1H2AC,HMGCS1,HSPA4,HSPA5,ITGAV,MIF,NRN1,PFKFB3,PLIN2,RET,SLC40A1,SLC7A5,SOD1,SOX9,STC2,UNG	Ap1,EGFR,EPAS1,FOS,FOXO1,HIF1A,HTT,JUN,MYC,NFE2L2,NFkB (complex),PPARA,PPARD,PPARG,RELA,SP1,SREBF1,STAT1,TP53,VHL,fatty acid,iron,nitric oxide	
P2	 	prednisolone	 	chemical drug	Inhibited	-3.674	bias	-0.370	-1.556	1.27E-04	APOE,APP,ARSA,ATG9A,CTSB,CTSS,CXCL10,CYGB,DAD1,DUSP10,EDN1,FAS,FKBP5,GAA,GABARAP,GM2A,HSPA8,INSR,LOC102724428/SIK1,MRPS16,NMT2,PARK7,PIK3CG,PRNP,RARRES3,SOD1,SPON2,SPP1,SQSTM1,STAT1,TP53,TPO,ZBTB16	AHR,Ap1,CEBPA,CREBBP,CSF2,EGR1,FOS,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,prednisolone	
P2	 	SOX4	1.657	transcription regulator	Activated	2.411	bias	0.444	0.099	1.28E-04	AES,B3GNT5,CAPN2,CD2,CD53,CD74,CHAC1,CNRIP1,CTNNA1,DDAH2,DUSP4,FCER1G,FHL1,FOS,HLA-DQB1,IFI30,IGFBP4,IGKC,LYZ,MBP,NCAM1,RNF144A,SERPINE2,SNX10,TAX1BP3,TENM4,TMEM176B,UCHL1	CEBPA,CTNNB1,JUN,NFkB (complex),SOX4,TCF,TP53	
P2	 	ABCB7	1.205	transporter	 	1.987	bias	0.432	1.128	1.33E-04	FECH,FTH1,FTL,TXN	ABCB7,HTT,NFE2L2,VHL,iron	
P2	 	SMC3	-1.002	other	 	1.982	bias	0.721	 	1.33E-04	HLA-DQA1,HLA-DQB1,HLA-DRA,ODC1	 	
P2	 	GW9662	 	chemical reagent	 	-0.000	 	-0.240	0.981	1.39E-04	ADIPOQ,AGER,APP,CD14,CD83,ESR2,FADS3,GDF15,GIPR,HLA-DRA,HSPA5,KLF4,NR1D1,PEA15,PLIN2,UCP2,VCAM1	CEBPA,CEBPB,FOXO1,GW9662,IGF1,JUN,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,fatty acid,rosiglitazone	
P2	 	dichlorovinylcysteine	 	chemical toxicant	Inhibited	-2.365	 	-0.166	-1.879	1.51E-04	ENO1,GLOD4,HSPA9,MDH2,ODC1,PKM,PPA2,PRDX5,STIP1	 	
P2	 	L-dopa	 	chemical - endogenous mammalian	 	-1.557	 	0.077	-2.221	1.52E-04	ADGRB2,AGPAT1,AIF1,AIFM2,ALPL,AREL1,BANF1,C1QA,CAPG,CD63,CEBPG,CHAC1,CHST11,COMT,CTSB,DENND1C,DGAT2,DMTN,DUSP6,FCGRT,FKBP5,FOS,FOSB,FTL,GAPDH,GLB1,HEXA,HLA-A,HRAS,LAMP2,LAPTM5,LRRC1,MAT2A,MBP,MIEN1,MSMO1,NAGLU,NDUFS4,NPC2,NTRK3,PDGFA,PER1,PIK3CG,PIK3R1,PLEK,PLEKHO2,PPP1R1B,PPP1R2,PPTC7,PSAP,RHOBTB2,RILP,RILPL1,RNF135,RUNDC3B,SCRN1,SH3BGRL3,SIAH2,SLC1A2,SLC24A2,SLC25A44,SOX9,SRM,SRPRB,STAB1,STXBP1,TAX1BP3,TMEM41B,TP53,TRAPPC1,TRIB3,TRIOBP,UBXN6,VAT1,VDAC1	CREBBP,ERK1/2,FOS,L-dopa,NFKBIA,NFkB (complex),RELA	
P2	 	NFKB1	-1.041	transcription regulator	 	1.947	bias	0.502	 	1.55E-04	ADORA1,AKR1B1,APOE,APP,BAMBI,BTG2,CCND2,CTSB,CXCL10,CXCL9,CYBB,EGR1,FAS,FCGRT,FOS,GBP1,HMOX1,IGKC,IL1RN,ISG15,KRT6B,MAT2A,MSR1,NR4A1,PDGFA,PI3,PTX3,SDC4,SOX9,STAT1,STIM1,SYTL1,TP53,VCAM1	AHR,CDKN2A,CREBBP,EP300,IKBKB,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	thyroid hormone	 	chemical - endogenous mammalian	 	-0.262	 	-0.018	-0.196	1.56E-04	APOE,ATF4,ATP5L,BTG2,CCNI,CD2,COMT,CRAT,DAD1,EGR1,FOS,G6PD,IGFBP4,LEP,MBP,ME1,MT-ND3,NHLH1,PER1,PGD,PLA2G2A,SERPINE2,SREBF2,STAT1,TCEA3,THRSP,UCP2,UQCR10	AHR,Ap1,CREB1,CREBBP,ESR1,ESR2,FOS,JUN,LEP,MYC,Mapk,NFKB1,NFkB (complex),PPARA,PPARG,Pde,Pka,RELA,RXRA,SP1,STAT1,STAT5B,THRB,estrogen receptor,thyroid hormone	
P2	 	PIK3R1	-2.091	kinase	Activated	2.168	bias	0.488	0.377	1.56E-04	ATF5,CCND2,CXCL10,DDIT3,ENG,FOS,HIF1A,HMOX1,ISG15,MKI67,NFE2L1,NFE2L2,PIK3R1,PKM,VCAM1	AKT1,Ap1,FOS,FOXO1,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PIK3R1,RELA,SP1,SRC,STAT1,TP53	
P2	 	BAPTA-AM	 	chemical reagent	 	0.770	bias	-0.480	2.331	1.57E-04	CXCL10,CYP3A5,DDIT3,EGR1,FOS,HSPA5,JUN,NR4A1,SOCS3,SPP1,VCAM1	Ap1,BAPTA-AM,CREB1,CREBBP,EGR1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pde,Pka,RELA,SP1,STAT1	
P2	 	atorvastatin	 	chemical drug	 	-0.199	 	-0.090	0.278	1.59E-04	ABCC1,ABCC3,ADIPOQ,AGER,APOB,APOE,CYBB,CYR61,EDN1,EGR1,ENG,FOS,FOSB,GADD45B,HMGCS1,HMOX1,ITGB2,JUN,LEP,MSMO1,MVD,NR4A1,PMVK,PRNP,RHEB,SLCO2B1,SOD1,SPP1,TMEM106A,VCAM1	APOE,ATF4,Ap1,CREB1,CTNNB1,E2F1,EGR1,FOS,FOXO1,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),NR1I2,P38 MAPK,PPARG,RELA,SP1,STAT1,TNF,atorvastatin	
P2	 	2-bromoethylamine	 	chemical reagent	Activated	2.897	bias	0.632	 	1.61E-04	ANXA1,ANXA2,CAPN6,CD14,EFEMP2,FCGR2A,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	IL5	2.871	cytokine	Activated	5.759	bias	0.684	 	1.63E-04	ALDOA,ANXA2,ASNS,ASS1,ATF4,CCND2,CCND3,CCR1,CD63,CHMP1A,CISD1,CKAP4,DUSP6,EGR1,ENO1,FAM162A,FAS,GCLM,HIF1A,HSPA5,HSPH1,IFI30,IL2RG,ITGAV,LCP2,LFNG,MAT2A,MS4A2,NACA,PDIA6,PKM,PSAT1,PSMB4,QSOX1,SLC1A5,SLC7A5,SNTB1,STK39	AKT1,CEBPB,CSF2,EGR1,FOXO1,HRAS,IFNG,IL5,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53	
P2	 	RET	4.076	kinase	 	1.212	bias	0.470	-0.409	1.64E-04	ANXA1,ATF4,CD151,CTSB,CXCL10,DUSP6,EGR1,FKBP4,FOS,HSPA8,HSPA9,HSPH1,MAF,MAPKAPK2,PRNP,RET,RTN4,STIP1,STMN2,TP53	CEBPB,ESR1,FOXO3,HIF1A,HRAS,HSF1,HSF2,IKBKB,JUN,MXI1,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,RET,SP1,TP53	
P2	 	etoposide	 	chemical drug	 	1.006	bias	0.338	-0.613	1.64E-04	ADAM17,BIN1,CREG1,CTSD,CYCS,CYP3A5,DUSP4,EEF1B2,FAS,FTH1,GDF15,HK1,JUN,MT-CO2,NR4A1,PEBP1,PFKL,PIK3R3,RHOBTB2,SEPT9,SQSTM1,TAF6,TNFRSF10B,TOP2A,TP53	AHR,Ap1,EGR1,ERK,FOS,JUN,Jnk,MAP3K1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,etoposide	
P2	 	TMBIM6	1.839	other	 	-0.186	 	0.055	-0.320	1.65E-04	DDIT3,EDEM1,ERN1,HMOX1,HSPA5,SEC61A1	ATF6,DDIT3,ERN1,NFkB (complex),TMBIM6,XBP1	
P2	 	ADRB1	-2.209	g-protein coupled receptor	 	0.246	 	0.240	-0.286	1.70E-04	APP,DDIT3,HSPA5,IRAK1,LEP,SLC9A1,THBS1	ADRB1,Ap1,CEBPB,CREB1,CREBBP,EGFR,EGR1,FOS,FOXO1,HTT,JUN,Jnk,MYC,NFKB1,NFkB (complex),P38 MAPK,Pde,Pka,RELA,SP1,STAT1,cyclic AMP	
P2	 	BID	1.040	other	 	1.912	bias	0.641	 	1.70E-04	ADAM17,C3AR1,CTSB,CTSD,CTSS,MT-CO2,TIMP1	BID,CEBPA,IL1B,NFKB1,NFKBIA,NFkB (complex),RELA	
P2	 	tanespimycin	 	chemical drug	 	-1.155	bias	-0.357	0.391	1.85E-04	AHSA1,CALM1 (includes others),CYCS,DDIT3,FAS,HNRNPAB,HSPA5,HSPA8,HSPA9,IARS,JUN,KIT,MIF,PRMT5,RPL30,RPL35,RPS16,RPS8,SNRPF,TYMP	Ap1,EGR1,FOS,FOXO1,FOXO3,IGF1R,JUN,Jnk,MAP2K1/2,MYC,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,STAT1,TP53,estrogen receptor,tanespimycin	
P2	 	hexachlorobenzene	 	chemical toxicant	Activated	3.592	bias	0.620	 	1.88E-04	ANXA1,ANXA2,ASNS,CD14,EFEMP2,FCGR2A,GAS5,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A	CREBBP,ERK1/2,FOS,NFKBIA,NFkB (complex),RELA,hexachlorobenzene	
P2	 	NPC1	1.168	transporter	 	-0.833	bias	-0.349	0.114	1.98E-04	ATF4,CD68,CTSB,CTSD,DDIT3,NPC2,S100A8,SCD,SRD5A1,SREBF2,STAT1	25-hydroxycholesterol,APP,Ap1,FOS,HIF1A,JUN,Mapk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NPC1,PPARA,PPARD,PPARG,RELA,SREBF1,STAT1,cholesterol,fatty acid	
P2	 	deoxycholate	 	chemical - endogenous mammalian	 	1.207	 	-0.074	1.459	1.98E-04	CYP4A11,DDIT3,EGR1,GJB2,GJB6,GLUL,HSPA5,KCNJ3,SLC1A2,SLC1A3,TNFRSF10B,TP53	AHR,Ap1,CREBBP,EGR1,EIF2AK3,FOS,FOXO1,FOXO3,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RB1,RELA,SP1,STAT1,TP53,TP63,TP73,deoxycholate	
P2	 	EPO	-2.605	cytokine	 	0.172	bias	0.370	-1.525	2.03E-04	ATP6V1B2,BZW2,CCND2,CCND3,CD52,CLGN,CREG1,DDIT3,EDN1,EGR1,FAS,FECH,FGF2,FOS,FOSB,GBA,GLUL,GSPT1,H2AFZ,JUN,KIT,KPNA2,LAPTM5,LCP1,NACA,NUPR1,PLCB2,RCC2,RPLP0,RPS23,SDHC,SOCS3,SOD1,SPP1,SYP,TP53,TSN,UCP2	Ap1,CREBBP,EDN1,EGR1,ELK1,EPO,ERK1/2,FOS,IRF8,JUN,Jnk,NFKBIA,NFkB (complex),RELA,SP1,STAT1,nitric oxide	
P2	 	IRS1	-1.015	enzyme	 	-0.940	bias	0.313	-1.757	2.18E-04	ADIPOQ,CIDEA,DDIT3,EGR1,FHL1,FMO1,FOS,GAS5,IGFBP4,INSR,LEP,PDGFA,PIK3R1,RAB9A,SIGLEC1,SPP1,SREBF2,TNXB,TRIB3,UCK1,UCP2	AKT1,ATF4,CEBPA,CEBPB,CREB1,E2F1,EGR1,FOS,FOXO1,FOXO3,INS,IRS1,Ins1,Insulin,NFkB (complex),NR1I2,PPARA,PPARG,RELA,SP1,STAT1,STAT5B	
P2	 	SP600125	 	chemical - kinase inhibitor	 	0.530	bias	-0.302	2.144	2.26E-04	AKR1C3,APOE,CD83,COL8A1,CSF1R,CXCL10,CXCL16,CYR61,EGR1,FAS,FOS,FOSB,HMOX1,ISG15,JUN,LEP,NR4A1,P4HA2,PAFAH1B2,PCK2,PER1,PTX3,SCD,SGPL1,SOCS3,SPP1,THBS1,TNFRSF10B,TP53,VCAM1	Ap1,EGR1,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,SP600125,STAT1,TNF	
P2	 	ADCYAP1	2.574	other	 	-0.499	 	0.172	-1.460	2.26E-04	ACTN1,ADCYAP1R1,AGER,BTG2,CCNI,CFL1,CNTNAP4,COL5A2,CXCL10,EGR1,FGFR2,FOS,GCLM,GYS2,H2AFZ,HK1,NPR3,NPY1R,NQO1,POR,PSMB7,RPSA,SCAMP3,SERPINE2,SLC1A2,SLC1A3,SOCS3,TENM2,TFPT,TGFB2,TMSB10/TMSB4X,TXNRD1,UCP2	ADCYAP1,AHR,EGFR,ERK,FOS,FOXO1,HTT,JAK2,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53	
P2	 	ursolic acid	 	chemical drug	 	-1.492	bias	-0.343	-0.468	2.27E-04	AKR1B1,EIF2S2,FGF2,FOS,GDF15,LEP,MARS,MKI67,NARS,SARS,TNFRSF10B,TP53,VCAM1	AHR,Ap1,EGR1,ERK,FOS,Gsk3,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTGS2,RELA,SP1,STAT1,TP53,ursolic acid	
P2	 	FAS	2.552	transmembrane receptor	 	0.972	 	-0.105	1.359	2.37E-04	AGER,ANXA2,ARHGDIA,BTG3,CCR1,CD83,CLTB,COL15A1,COL8A1,CXCL10,CXCL9,DUSP10,EGR1,FAS,FOS,FOSB,GBP1,GDE1,GLIPR1,HLA-DQB1,IL10RA,IL17RA,ITGA7,ITGAV,JUN,KIF3B,LAMP3,MAP4K4,MBOAT7,MIF,MYO5A,NR4A1,NR4A2,PHLDA2,PIK3CG,PLIN2,PPFIBP2,PTX3,RHEB,RRAGD,SIAH2,SPP1,TLN2,TLR8,TRAF3,VCAM1	CEBPA,CEBPB,FAS,IFNG,IL10,IL1B,IRF8,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TCR	
P2	 	ADCY	 	group	 	0.625	bias	0.466	-0.395	2.52E-04	FGF2,FOS,LEP,NR4A2,PER1,TP53,TXN	ADCY,ATP,CEBPB,CREB1,CREBBP,DDIT3,HTT,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),NR3C1,Pde,Pka,RELA,RNA polymerase II,STAT1,adenosine,cyclic AMP	
P2	 	MTPN	1.921	transcription regulator	Activated	2.009	bias	0.721	 	2.53E-04	ANXA1,CCND2,CCND3,COL8A1,EDN1,ENG,FAS,FOS,GAS5,JUN,MIF,MTPN,S100A8,SPP1,TGFB2,VCAM1	AHR,CREBBP,JUN,MTPN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,TP53	
P2	 	HOXA10	-4.833	transcription regulator	 	-1.035	 	-0.240	0.208	2.56E-04	ADIPOQ,ALOX5AP,ALPL,APOE,ARL2,CA3,COL15A1,CSTA,CTSG,CYBB,FCER1G,HLA-DQA1,HLA-DQB1,HMBS,LYZ,MAP1B,ME1,NCAM1,NR4A1,PIK3R1,RHOG,RPL37A,SCD,THRSP,TNXB,TP53,YWHAG	 	
P2	 	N1,N11-diethylnorspermine	 	chemical drug	Activated	2.449	 	-0.103	2.702	2.71E-04	MT-CO1,MT-ND3,MT-ND4,MT-ND4L,MT-ND6,TP53	 	
P2	 	STOX1	-3.382	other	 	 	 	 	 	2.71E-04	ACTG1,CALM1 (includes others),GADD45B,MAPT,RAB10,RPL17	 	
P2	 	manganese	 	chemical - endogenous mammalian	 	0.277	bias	0.288	-0.282	2.71E-04	DDIT3,GAPDH,HSPA5,PARK7,SLC1A2,SLC40A1	CDKN2A,EP300,MYC,SP1,TP53,YY1,manganese	
P2	 	romidepsin	 	biologic drug	 	-0.275	 	0.114	-0.573	2.72E-04	DDIT3,DUSP6,EGR1,FGF2,FOS,HIF1A,INSR,ITGAV,JUN,RAC1,SLC1A2,TNFRSF10B,TP53	CREBBP,ELK1,ERK1/2,ESR1,FOS,FOXO1,HIF1A,Hdac,JUN,MYC,NFKBIA,NFkB (complex),RAF1,RELA,SP1,TCF,TP53,TP63,TP73,reactive oxygen species,romidepsin	
P2	 	IL1A	-4.962	cytokine	 	1.837	bias	0.474	-0.683	2.76E-04	ADAMTS5,ALDH3A2,APP,CD83,CXCL10,CYP3A5,CYR61,F2RL3,FAM89B,FAS,FGF2,FOS,FTH1,GBP1,HMOX1,IL1RN,IRAK1,ITGAV,JUN,KIT,LEP,LGALS9,PDGFA,PI3,PTX3,S100A7,S100A8,SAA1,SAA2,SPP1,VCAM1	AHR,CEBPB,CREBBP,IFNG,IL1A,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	CD40LG	-2.597	cytokine	Activated	2.991	bias	0.581	 	2.78E-04	ADAM17,ALCAM,ALG3,ANXA7,APRT,ATF5,BTG3,CBX3,CCND3,CCR1,CD63,CD83,CLIP1,CXCL10,DUSP4,EGR1,FAS,FBL,FOS,FOSB,G0S2,HIF1A,HLA-DQA1,HLA-DQB1,IGHG3,IL10RA,ISG15,JUN,KIF2A,LAMP3,MIF,NINJ1,ORC5,PLEK,PMVK,PREPL,PSMB10,PSME1,PSMG1,RAB9A,STAT1,TNPO1,TRAF3,TREM2,TUBB,TYMP,VCAM1	CD40LG,CEBPA,CEBPB,CREBBP,FAS,IFNG,IL1B,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	NFIC	1.281	transcription regulator	 	 	 	 	 	2.79E-04	ADAM12,ALDOA,HTRA1,LHCGR,PDGFA,SLC25A5,TP53,TPO	 	
P2	 	POLG	-1.034	enzyme	 	 	 	 	 	2.79E-04	COX7A2L,EEF1B2,MT-CO2,MT-CO3,RPS16,RPS19,RPS24,RPS5	 	
P2	 	2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine	 	chemical toxicant	Activated	3.317	bias	0.583	 	3.05E-04	CCT2,CCT5,HSPA5,HSPA8,HSPH1,PSMA6,PSMB2,PSMB4,PSME1,RAN,UBA1	 	
P2	 	N-acetyl-L-cysteine	 	chemical drug	Inhibited	-3.072	bias	-0.379	-1.111	3.07E-04	ATF4,CCND2,CXCL10,CYBB,CYR61,DDIT3,EDN1,EGR1,FAS,FGF2,FOS,GCLM,GLB1,GNL3,GSTP1,HIF1A,HLA-DRA,HMOX1,HSPA5,JUN,LEP,MSR1,NFE2L2,NQO1,OSGIN1,SPP1,TNFRSF10B,TP53,VCAM1	Ap1,FOS,FOXO1,HIF1A,JUN,MYC,N-acetyl-L-cysteine,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),Pkc(s),RELA,SP1,STAT1,nitric oxide,reactive oxygen species	
P2	 	ACOX1	-1.264	enzyme	Inhibited	-2.600	 	-0.138	-1.942	3.09E-04	ANXA2,CBR1,CD63,CRAT,CSTB,CYP4A11,DDIT3,GOT1,GSTP1,HLA-DQA1,HSPA5,LHPP,LONP1,NFE2L2,NUPR1,PLIN2,RPL12,RPS24,SLCO2B1,SQSTM1,TP53,TRIB3,UCP2	ACOX1,JUN,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SREBF1,fatty acid	
P2	 	EGR1	-3.966	transcription regulator	Activated	2.185	bias	0.526	 	3.19E-04	CCND2,CCR1,DUSP4,EGR1,FAS,FGF2,FTL,GADD45B,GDF15,HMOX1,JUN,LHCGR,LYZ,ME1,NR4A1,PDGFA,PDGFC,PEG10,SLC12A2,SLC4A2,SOD1,SPP1,THBS1,TIMP1,TP53,VCAM1	AHR,Ap1,CEBPA,CEBPB,EGR1,ELK1,EP300,ERK,ESR1,FOS,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF,TP53	
P2	 	phenylbutazone	 	chemical drug	Activated	3.105	bias	0.553	 	3.24E-04	ANXA1,ANXA2,ASNS,CAPN6,EFEMP2,FCGR2A,GAS5,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A,TUBB	 	
P2	 	SLC13A1	-3.983	transporter	 	-1.213	 	-0.078	-0.890	3.24E-04	ACTG1,AKR1C3,C6,EDEM1,G0S2,HSPA5,HSPA8,HSPB1,MAD2L2,MVD,NRN1,RPL41,SCD,SPP1,SRPRA,TUBA1C,YARS	 	
P2	 	RASSF1	-1.138	other	 	-0.477	 	0.172	-1.160	3.37E-04	APOE,CCND2,CREG1,DAB2,EGR1,EPB41L3,FGF2,FOS,GDF15,HIST1H2BC,KLF4,LITAF,MAP1B,MYL9,SOX9,SPP1	AHR,CREBBP,ELK1,ERK,ERK1/2,FOS,HRAS,JUN,MAPK3,MYC,NFKBIA,NFkB (complex),RASSF1,RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	sphingosine-1-phosphate	 	chemical - endogenous mammalian	 	-0.569	bias	0.352	-1.941	3.37E-04	ANXA2,CXCL10,EGR1,ERN1,FAS,FGF2,FOS,HIF1A,JUN,LEP,NFE2L2,PDGFA,PLA2G2A,THBS1,TIMP1,VCAM1	AHR,AKT1,ERK,FOXO1,IL6,JUN,NFKB1,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,docosahexaenoic acid,sphingosine-1-phosphate	
P2	 	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	 	chemical toxicant	 	-0.649	bias	0.305	-1.688	3.39E-04	APP,CLDN1,CYBB,EGR1,FGF2,FOS,FOSB,HSPB1,JUN,NR4A1,NR4A2,PARK7,PTPRC,TP53	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,AHR,Ap1,CEBPA,CREBBP,EGR1,FOS,IL1B,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	Il3	 	cytokine	 	0.057	 	0.240	-0.690	3.39E-04	ATF5,CCND2,CCND3,CD14,CD68,CSF1R,EGR1,FAS,FOS,HRAS,LYZ,SPP1,TP53,YWHAG	AKT1,CREBBP,ELK1,FOXO1,HRAS,IRF8,Il3,JUN,MYC,Mek,NFKBIA,NFkB (complex),PTPN11,RELA,SP1,SPI1,STAT1,TP53	
P2	 	GAST	-2.951	other	 	1.441	bias	0.586	 	3.43E-04	ANXA7,ATF4,EGR1,FOS,JUN,MDH2,NACA,NARS,ODC1,PIK3R1,POR,RAC1,RPS19,SLC4A2,VCAM1	Ap1,CREB1,CREBBP,CTNNB1,ERK1/2,FOS,FOXO1,GAST,Insulin,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PRKCA,PRKCE,RELA,STAT1	
P2	 	RAF1	1.184	kinase	 	1.902	bias	0.629	 	3.44E-04	ANXA1,CD74,CDC42EP1,CLDN1,CRYAB,CSTA,DUSP4,DUSP6,EGR1,FAS,FOS,GRN,HIF1A,HNRNPAB,HPCAL1,HSPB1,JUN,MCF2L,MKI67,NINJ1,PCSK6,PHLDA2,RAC1,RAN,RET,RPS2,ST6GALNAC2,TIMP1,TUBB2A,TUBG1	Ap1,CREBBP,ELK1,ERK1/2,FOS,FOXO1,FOXO3,HRAS,IL6,JUN,MAP2K1/2,MAPK3,MYC,NFKB1,NFKBIA,NFkB (complex),RAF1,RELA,SP1,STAT1,TP53	
P2	 	8-bromoguanosine 3',5'-cyclic monophosphate	 	chemical - kinase inhibitor	 	1.154	 	0.225	0.487	3.47E-04	CYP3A5,EDN1,FOS,HINT1,HLCS,HMOX1,PCCA,TP53,VCAM1	8-bromoguanosine 3',5'-cyclic monophosphate,AHR,ATF4,Ap1,E2F1,EGR1,ERK,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),NR1I2,P38 MAPK,PPARG,RELA,SP1,STAT1	
P2	 	Fgf	 	group	 	1.023	bias	0.605	 	3.47E-04	CCND3,FOS,GNL3,JUN,ODC1,PER1,SPRY4,STAT1,VCAM1	AHR,Ap1,CREBBP,ERK,ERK1/2,FOS,Fgf,JUN,MYC,Mapk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,RELA,SP1,STAT1	
P2	 	ROCK2	-1.205	kinase	Activated	2.954	bias	0.495	1.490	3.47E-04	APP,DSG1,FAS,KRT10,PI3,S100A7,S100A8,SPINK5,SPP1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,ROCK2,STAT1	
P2	 	3-nitropropionic acid	 	chemical toxicant	 	0.684	 	0.144	0.282	3.54E-04	APP,ATP5J,ATP6V1B2,CBR1,GAPDH,JUN,LDHB,NQO1,PPP1R1B,SLC7A11,SQSTM1,TP53	3-nitropropionic acid,APP,Ap1,BACH1,CREB1,CREBBP,EGR1,FOS,HIF1A,HTT,Hdac,Jnk,L-glutamic acid,NFE2L2,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,TP53	
P2	 	Sos	 	group	 	 	 	 	 	3.63E-04	ABCC1,ADAM12,AKR1C3,APLP2,CAMK2D,CLIP1,COL16A1,DAP,DAPK2,ENAH,FOS,GBA,GJB6,GM2A,HMOX1,HSPB8,KIF2A,KIF5B,MAP4K4,MMRN1,NFE2L2,ODC1,PFN1,PKN1,PXK,RFNG,SCD,SIRPA,TPP1	AHR,Ap1,CEBPB,CTNNB1,ERK,ESR1,FOS,JUN,KRAS,MAP2K1,MYC,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,Sos,TP53	
P2	 	6,7-dinitroquinoxaline-2,3-dione	 	chemical reagent	 	-1.732	bias	0.721	 	3.77E-04	EGR1,FOS,FOSB,JUN	6,7-dinitroquinoxaline-2,3-dione,Ap1,JUN,NFkB (complex)	
P2	 	TRIB3	13.140	kinase	Inhibited	-2.778	bias	-0.333	-1.854	3.77E-04	ASNS,DDIT3,GARS,GDF15,PCK2,PSAT1,STC2,TRIB3	ATF4,Ap1,CEBPA,CEBPB,DDIT3,EGR1,FOS,JUN,Jnk,NFkB (complex),PPARG,RELA,RNA polymerase II,TRIB3	
P2	 	E64d	 	chemical - protease inhibitor	 	0.200	 	0.144	-0.117	3.81E-04	APP,CD74,FGF2,SQSTM1,TP53	APP,Ap1,E64d,EGR1,FOS,HIF1A,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1	
P2	 	EIF4G2	1.690	translation regulator	 	1.342	bias	0.721	 	3.81E-04	CCND2,CTSD,HIF1A,JUN,SERPINE2	 	
P2	 	pCPT-cAMP	 	chemical - kinase inhibitor	 	-1.427	bias	0.577	 	3.81E-04	APP,EGR1,FOS,JUN,NR4A1	Ap1,CREB1,CREBBP,EGR1,ELK1,ESR1,FOS,JUN,MAPK3,NFkB (complex),Pde,Pka,RELA,SP1,STAT1,TP53,pCPT-cAMP	
P2	 	clozapine	 	chemical drug	 	-0.197	bias	0.422	-1.556	3.84E-04	CIDEA,DVL3,EGR1,FOS,HMGCS1,NR4A1,NR4A2,PEA15,PPP1R9B,PRKACB,SCD,SREBF2,SYP	AKT1,CEBPB,CHRM1,CREB1,EGR1,FOS,FOXO1,Insulin,JUN,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,clozapine,cyclic AMP,dopamine,estrogen receptor	
P2	 	CIDEB	1.106	other	 	 	 	 	 	3.89E-04	ADIPOQ,LEP,PLIN2	 	
P2	 	bongkrekic acid	 	chemical toxicant	 	 	 	 	 	3.89E-04	CYCS,MT-CO3,VCAM1	 	
P2	 	KCNE3	-1.054	ion channel	 	 	 	 	 	3.97E-04	AKR1C3,APOLD1,BCAT1,CSRNP1,DUSP6,FOSB,KLF4,NR4A1,NR4A2,OSGIN1,PER1,PTPRQ,SLC2A5,VSIG4	 	
P2	 	docosahexaenoic acid	 	chemical drug	 	-1.334	bias	-0.293	0.072	4.09E-04	ADIPOQ,APOE,APP,ATF4,CYCS,DDIT3,ERN1,FAS,FOS,HMOX1,LEP,MAPT,NFE2L2,PIK3R1,PLTP,SCD,SMPD1,SOCS3,TGFB2,TGFBR1,THBS1,TIMP1,UCP2,VCAM1	ADIPOQ,AKT1,CEBPB,CTNNB1,DDIT3,EGR1,FOXO1,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,RELA,SP1,STAT1,TNF,docosahexaenoic acid,palmitic acid	
P2	 	Ins1	 	other	 	-0.092	bias	0.281	-1.752	4.22E-04	ADIPOQ,ALAS1,ARF1,CCND3,CRAT,CRYAB,DDIT3,DGAT2,DYNLL1,EDN1,EGR1,ERP29,FGF2,FOS,G6PD,GAPDH,GSTP1,HMGCS1,HNRNPK,IGFBP4,INSR,JUN,LDHB,LEP,MAPT,MBP,MIF,NDUFS4,ODC1,PER1,PIK3R1,PLIN1,PLIN2,SCD,SDHB,SOCS3,SYP,THRSP,TIMP1,UBE2D2	AGT,ARNT,CEBPA,CEBPB,D-glucose,EDN1,ELK1,FOXO1,HIF1A,IGF1,Ins1,JUN,MYC,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,cyclic AMP	
P2	 	reactive oxygen species	 	chemical toxicant	Activated	2.596	bias	0.603	 	4.22E-04	ABCC1,ADAM17,ADIPOQ,CSF1R,DDIT3,EDN1,FAS,FGF2,HIF1A,HMOX1,HSPA5,JUN,LEP,NFE2L2,PRDX5,SYP,TNFRSF10B,TP53,UCP2,VCAM1	AHR,Ap1,CREBBP,EGR1,FOS,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,TNF,reactive oxygen species	
P2	 	alpha-tocopherol succinate	 	chemical drug	 	-1.718	bias	-0.388	-0.790	4.23E-04	EGR1,FGF1,FGF2,HIF1A,UCP2,VCAM1	Ap1,CREBBP,EGR1,ERK1/2,FOS,FOXO1,HIF1A,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,alpha-tocopherol succinate,reactive oxygen species	
P2	 	CHUK	1.209	kinase	Activated	3.222	bias	0.594	 	4.29E-04	ACKR3,CCR1,CTSB,CXCL10,DUSP6,ENAH,FAS,FOS,GADD45B,GM2A,GRN,HLA-A,HMOX1,IL1RN,ISG15,MAT2A,NAGLU,PLD3,PTX3,SEMA3C,SERPINE2,SFRP1,SNX10,SOCS3,SPP1,SQSTM1,TMEM176B,TP53,VCAM1	CEBPB,CHUK,IKBKB,IKBKG,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53	
P2	 	XBP1	-1.028	transcription regulator	Activated	4.024	bias	0.621	 	4.29E-04	APP,DAD1,DDIT3,DERL1,DNAJB11,DNAJC1,EDEM1,ERP29,FAS,FKBP2,HLA-DRA,HMOX1,HSPA13,HSPA5,HYOU1,KLF4,PDIA6,PHLDA2,PRNP,RPN2,SEC61A1,SEC61B,SOD1,SRP19,SRPRA,SRPRB,SSR4,TXN,VCAM1	ATF6,Ap1,BACH1,DDIT3,EGR1,ERN1,FOS,Immunoglobulin,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,XBP1	
P2	 	valsartan	 	chemical drug	 	-1.224	bias	-0.417	-0.009	4.68E-04	ADIPOQ,APP,CYBB,EDN1,FGF2,FOS,KIT,LEP,SPP1,TIMP1	AGT,Ap1,CREB1,FOXO1,HIF1A,IRF8,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PTPN11,RELA,SPI1,STAT1,valsartan	
P2	 	KDM5A	1.080	transcription regulator	Inhibited	-4.146	bias	-0.632	 	4.73E-04	ATP6V1F,COA3,COX14,COX17,GHITM,HMOX1,ICT1,MRPL17,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFA9,NDUFS4,NME1,PARK7,PGD,SDHB,SDHC,UQCRQ,VDAC1	 	
P2	 	E. coli B4 lipopolysaccharide	 	chemical toxicant	Activated	3.997	bias	0.471	1.230	4.79E-04	ADAMTS5,ANXA1,B3GNT5,C12orf49,C1QB,CD83,CLDN1,CXCL10,CXCL9,CYP3A5,EVI2B,F13A1,FAS,FCER1G,FOSB,GLIPR1,HLA-A,HMOX1,HSPB8,IL1RN,IMP4,LCP1,LCP2,PLEK,PPP1R1B,PTPRC,RAB10,SLC14A1,SOCS3,ST6GALNAC2,STAB1,STC2,TOLLIP,TP53,TSPO,VCAM1	CEBPA,CEBPB,CHUK,CTNNB1,E. coli B4 lipopolysaccharide,IFNG,IL1B,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	TFAP2A	-1.430	transcription regulator	 	0.341	 	-0.095	0.649	4.80E-04	ALCAM,ANXA1,APOE,G3BP2,GLO1,KLF4,KRT14,KRT5,LHCGR,PAG1,POR,PSAP,RPLP0,RPS5,SLC19A1,SMPD1,TPM3	Ap1,CEBPA,CTNNB1,EGR1,ELK1,ESR1,JUN,NFkB (complex),RNA polymerase II,SP1,SP3,TCF,TFAP2A,TP53	
P2	 	ARNT2	-1.702	transcription regulator	Activated	3.900	bias	0.721	 	5.05E-04	AGER,AKR1B1,AOX1,APOE,CCR1,CFL2,EGR1,EIF5A,FCGR2A,GALNT4,GLUL,HLA-A,ICMT,IGFBP4,KRT5,LCP1,MRPL37,MSC,MTPN,NACA,NAP1L4,NDUFA1,OAZ1,PDLIM4,PEA15,PFN1,SIM1,TYROBP,UBA1	 	
P2	 	calcitriol	 	chemical drug	 	-0.549	 	-0.046	-0.266	5.16E-04	ABCC3,ANLN,ANXA2,APITD1/APITD1-CORT,APP,ATP2B1,CCND3,CD14,CES1,CSF1R,CXCL10,CYR61,DCTPP1,DOK5,DUSP10,EDN1,EGR1,ETV5,FAS,FECH,FOS,G6PD,GAPDH,GIT1,H2AFZ,IL10RA,IL1RN,ISG15,JUN,KLF4,KPNA2,KRT6A,LEP,MAF,NCAM1,NUPR1,ODC1,PPP1CA,PTGFR,RNF144A,S100A8,SOCS3,SOD1,SPP1,STXBP6,TGFB2,THBS1,TLR8,TNFRSF10B,TP53,TXN,UCP2,WSB1	AHR,CREBBP,ERK,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,calcitriol	
P2	 	poly rI:rC-RNA	 	biologic drug	Activated	2.783	bias	0.530	 	5.54E-04	ACSL3,AFAP1,ANXA1,ATF4,CCND3,CD14,CD209,CD74,CD83,CXCL10,CXCL9,EDN1,EGR1,FAS,FGF2,FOS,GADD45B,GBP1,GDF15,HLA-A,HLA-G,IL10RA,IL2RG,IRAK1,IRF5,ISG15,JUN,KLF4,LGALS9,LYZ,MSR1,NR4A1,NR4A2,PCK2,PIM3,PSMA3,PTPRJ,RARRES3,SDC4,SLC40A1,STAB1,STAM,STAT1,THBS1,TNFRSF10B,TOLLIP,TP53,TPO,UBQLN1,VCAM1	CEBPA,CEBPB,CREBBP,IFNG,IL1B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,poly rI:rC-RNA	
P2	 	NRF1	-1.352	transcription regulator	Activated	2.538	bias	0.343	1.458	5.54E-04	ALAS1,COX7B,CYCS,FTH1,GCLM,HMOX1,IL1RN,NQO1,SURF1,TP53,VDAC1	 	
P2	 	Lh	 	complex	 	-0.202	 	0.199	-0.934	5.62E-04	ACP2,ACTN1,ALPL,ARHGAP35,ARPC4,ATP2B1,CCND2,CDK16,COL15A1,CSNK1A1,DAB2,FKBP5,FLNC,FOS,GBP1,GNB1,LHCGR,MAP4K4,MSMO1,NPC2,P4HA2,PER1,PLPP1,PTX3,RAB5C,SFRP4,STAT1,STIP1,TGFB2,THBS1,TMBIM6,TNFRSF12A,TP53	AHR,AKT1,Cg,EGR1,ERK,ESR1,FOS,FOXO1,JAK2,JUN,Lh,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SP1,SP3,STAT1,estrogen receptor,progesterone	
P2	 	metformin	 	chemical drug	 	-1.990	 	-0.244	-0.918	5.74E-04	ADIPOQ,AGER,APOB,ATF4,BAMBI,CCND2,CYP3A5,DDIT3,DVL3,ERN1,FOS,FTH1,GLO1,HMOX1,HSPA5,IL1RN,INSR,LEP,PEA15,PKM,PLIN2,UCP2	ARNT,D-glucose,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT1,TNF,metformin,rosiglitazone	
P2	 	D-galactosamine	 	chemical - endogenous mammalian	 	1.364	bias	0.607	 	5.79E-04	CD14,CTSB,CXCL10,FOS,GDF15,JUN,MAPK9,NFE2L2,SDC3,TIMP1	Ap1,CEBPB,D-galactosamine,EGR1,FOS,IFNG,IL10,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	ouabain	 	chemical drug	 	-0.265	bias	0.297	-1.180	5.79E-04	ANXA5,DDIT3,FOS,HIF1A,HSPA5,HSPA8,HSPA9,TP53,YWHAG,YWHAH	Ap1,EDN1,EGR1,ELK1,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pkc(s),RELA,SP1,STAT1,ouabain,reactive oxygen species	
P2	 	fulvestrant	 	chemical drug	 	0.195	 	-0.160	1.045	6.01E-04	ASNS,ATF4,BARD1,CD74,CNBP,COMT,CXCL10,CYR61,DYNLL1,EGR1,ESR2,FKBP1A,FOS,G6PD,GAB2,GJB2,GSTP1,HRAS,JUN,MAZ,NME1,PPP1R9B,RAC1,SIAH2,SLC25A5,SLC7A5,SLC9A3R1,SMPD1,SNCG,SOD1,SQSTM1,TGFB2,TP53,VCAM1	AHR,Ap1,EGR1,ELK1,ESR1,ESR2,FOS,JUN,MYC,Mapk,NFKB1,NFkB (complex),PPARG,RELA,SP1,STAT1,TP53,VEGFA,estrogen receptor,fulvestrant,nitric oxide	
P2	 	P38 MAPK	 	group	Activated	2.653	bias	0.593	 	6.02E-04	ADAM17,ADIPOQ,AGER,ANXA5,ASS1,CCND2,CD83,CXCL10,CXCL9,CYBB,DDIT3,EDN1,EGR1,FAS,FGF2,FLNA,FOS,GBP1,HIF1A,HMOX1,HSPA5,HTRA1,IL1RN,ITGAV,ITGB2,JUN,KLF4,LEP,MAP4K4,MIF,MT-CO2,NFE2L2,NR4A1,RAB7A,SOCS3,STAT1,STIM1,THBS1,TIMP1,TNFRSF10B,TOP2A,TP53,VCAM1	Ap1,CEBPA,CEBPB,EGR1,FOS,IFNG,IL1B,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	GW3965	 	chemical reagent	 	0.713	 	0.138	0.265	6.05E-04	APOE,APP,CXCL10,DGAT2,IL1RN,NR1D1,NR5A2,PLIN2,PLTP,SCD,SOCS3,THRSP	ESR1,GW3965,NFkB (complex),NR3C1,PGR,estrogen receptor,progesterone	
P2	 	cardiotoxin	 	chemical - other	Activated	3.317	bias	0.721	 	6.16E-04	APRT,ATP6V1A,CAPN6,CCND2,CCND3,CCR1,CSF1R,FBL,G6PD,GM2A,HSPA5,IL10RA,IL1RN,IL2RG,ITGB2,KPNA2,PGAM1,PTPRC,RPSA,SPP1,TIMP1,TXNRD1,UCP2	 	
P2	 	flutamide	 	chemical drug	 	-1.129	 	-0.115	-0.785	6.26E-04	CYP3A5,CYP4B1,CYR61,DCX,ESR2,FOS,HIF1A,ME1,MKI67,NQO1,NR4A1,ODC1,SRD5A1	CREB1,CTNNB1,ESR1,ESR2,FOS,FSH,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,beta-estradiol,flutamide	
P2	 	lomustine	 	chemical drug	Activated	3.053	bias	0.608	 	6.26E-04	ANXA1,ANXA2,ASNS,CAPN6,CD14,FCGR2A,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TNFRSF12A,TUBB	 	
P2	 	estrogen	 	chemical drug	Activated	2.383	bias	0.474	-0.014	6.28E-04	AP3D1,APOB,APOE,ATP5J,BARD1,COL15A1,COMT,CTSD,CYBB,CYR61,EGR1,ESR2,FAS,FOS,FTH1,G6PD,GJB2,HIF1A,HSPH1,IGFBP4,JUN,MVD,NME1,NR4A1,PTX3,RET,SERPINE2,SOD1,SPP1,SRM,TGFB2,TGFBR1,TOP2A,TP53,TRIM16,UNG	AHR,CEBPA,CEBPB,EGR1,ELK1,ESR1,ESR2,FOXO1,IGF1,JUN,MYC,Mek,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF,TP53,estrogen,estrogen receptor	
P2	 	Ren2	 	peptidase	 	0.826	bias	0.328	0.189	6.35E-04	CYBB,CYCS,MT-CO1,RAC1,SPP1,TIMP1	AGT,HIF1A,JUN,NFKBIA,NFkB (complex),Ren2,STAT1	
P2	 	diethylmaleate	 	chemical toxicant	Activated	2.378	 	0.090	2.164	6.35E-04	GSTP1,HMOX1,MAFG,NQO1,SLC3A2,SLC7A11	BACH1,NFE2L2,NFkB (complex),RELA,diethylmaleate	
P2	 	STAT4	-1.104	transcription regulator	Activated	3.939	bias	0.721	 	6.47E-04	ASPH,ATF4,CCNI,CXCL10,DAP,DAPK2,DDAH2,DHX8,DPM3,ETV5,FCER1G,FYB,GAS5,GBE1,HLA-DQB1,IL10RA,ISG15,ITGA7,KDM6B,P4HA2,PER1,PGP,RAMP2,RRAGD,SH3GLB1,SOCS3,STAT1,STC2,TIMP1,VDAC1	CEBPB,CREBBP,IFNG,IL4,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,STAT4	
P2	 	YY1	1.209	transcription regulator	Activated	2.271	 	0.058	2.110	6.49E-04	ALCAM,ATF4,BTG2,CAPG,CBX3,COL15A1,CRYAB,CYBB,DMD,EEF1B2,FAS,FCER1A,FOS,GBP1,HIST1H4C,HLA-DRA,HMOX1,HSPA5,KIF5B,MAT2A,MKI67,PDGFA,PNRC2,RAB8B,RPL30,SIM1,SLC1A2,TGFB2,TGFBR1,TOP2A,TP53,UNG,WSB1	Ap1,CDKN2A,CREBBP,EGR1,ELK1,EP300,ESR1,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),PPARG,RB1,RELA,SP1,TP53,TP63,TP73,YY1,estrogen receptor	
P2	 	androgen	 	chemical drug	 	-1.062	 	-0.016	-1.011	6.52E-04	ADAMTS15,AES,AKR1C3,ARHGEF26,BTG2,CA3,CCND3,CTSB,FGF2,FGFR2,FLNA,FOS,JUN,NR4A1,PARK7,PIK3R1,PIP,PLPP1,PTPRC,PTPRK,RET,SDC4,SOX9,STIM1	AHR,Ap1,CEBPA,CTNNB1,ERK,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PRL,Pkc(s),RELA,SP1,SRC,STAT1,STAT5B,TCF,TP53,androgen	
P2	 	AIFM1	1.486	enzyme	 	1.308	bias	0.721	 	6.57E-04	CHCHD4,COX17,MT-CO2,NDUFA13,NDUFA9	 	
P2	 	CHRM3	-1.060	g-protein coupled receptor	Inhibited	-2.000	bias	0.721	 	6.57E-04	CYR61,EGR1,FOS,HMOX1,LEP	Ap1,CHRM1,CHRM3,CREB1,EGR1,FOS,JUN,LEP,Mapk,NFKB1,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,dopamine,estrogen receptor	
P2	 	clioquinol	 	chemical drug	 	0.447	bias	0.288	-0.197	6.57E-04	APP,FOS,JUN,KDM6B,TP53	APP,Ap1,CREB1,CREBBP,FOS,HIF1A,HSF1,HTT,Hdac,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SOD1,SP1,STAT1,TP53,clioquinol,dopamine,estrogen receptor	
P2	 	putrescine	 	chemical - endogenous mammalian	 	0.555	bias	0.577	 	6.57E-04	FOS,JUN,MAT2A,OAZ1,TP53	ELK1,FOS,JUN,MAPK3,NFkB (complex),TP53,putrescine	
P2	 	EIF2AK4	1.272	kinase	Activated	2.784	bias	0.566	 	6.58E-04	ASNS,ATF4,CHAC1,DDIT3,EGR1,MBP,PCK2,PSAT1	 	
P2	 	PLIN5	-2.582	other	Activated	2.828	 	-0.051	2.974	6.58E-04	ACSM5,ATF4,GSS,HMOX1,NFE2L2,NQO1,POR,TXNRD1	 	
P2	 	indole-3-carbinol	 	chemical drug	 	-0.187	 	0.000	-0.187	6.58E-04	ANXA1,CYP3A5,FMO1,FOS,GDF15,LCP1,NFE2L2,SPP1	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,indole-3-carbinol	
P2	 	glucosamine	 	chemical - endogenous mammalian	 	-0.449	 	-0.164	0.054	6.68E-04	APOB,ASS1,DDIT3,INSR,LEP,MDH2,MT-ND1,NDUFA1,PCCB,SLC25A5,TP53	2-deoxyglucose,CREB1,CTNNB1,ELK1,FOXO1,FOXO3,HMGA1,IRS1,Insulin,JUN,LEP,MYC,NFKB1,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,STAT5B,TP53,glucosamine	
P2	 	bexarotene	 	chemical drug	 	-0.718	 	0.205	-1.667	6.77E-04	AKR1C1/AKR1C2,AKR1C3,ALCAM,APOE,APP,ASNS,CEBPG,CYCS,CYR61,GARS,MAF,ODC1,PIK3R1,PNO1,RORB,SCD,SIAH2,SLC7A1,SLC7A5,SYP,TGFB2,VAMP8,VCAM1	CEBPA,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,THRB,TNF,bexarotene	
P2	 	GNA15	1.892	enzyme	 	 	 	 	 	6.95E-04	ACKR3,CRYAB,CYCS,DAB2,DDIT3,FHL1,FMO1,GLUL,HMOX1,MAT2A,NPR3,ODC1,SCN2A,SLC7A1,TIMP1,TRIB3,UNC5B	Ap1,CHUK,CTNNB1,EGR1,FOS,GNA15,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	L-glutamic acid	 	chemical - endogenous mammalian	 	-0.633	bias	0.407	-2.200	6.95E-04	APP,EGR1,FGF2,FOS,FOSB,GADD45B,HEXA,JUN,LEP,MAP1B,PER1,PLIN2,SLC1A2,SLC1A3,SORBS1,TIMP1,TP53	ADCY,Ap1,CEBPA,FOS,HTT,IL1B,JUN,L-glutamic acid,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,Pkc(s),RELA,SP1,TNF	
P2	 	diallyl trisulfide	 	chemical - endogenous non-mammalian	Activated	2.433	 	0.160	2.043	7.02E-04	FAS,FOS,HMOX1,JUN,NFE2L2,NQO1,TP53	AHR,Ap1,EGR1,ERK,FOS,FOXO1,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,diallyl trisulfide,reactive oxygen species	
P2	 	DDIT3	6.612	transcription regulator	Activated	2.643	bias	0.374	1.392	7.16E-04	ATF5,DDIT3,HMOX1,HSPA5,KRT6B,NFE2L2,SARS,TENM4,TNFRSF10B,TRIB3,WARS,XPOT	DDIT3,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	rotenone	 	chemical toxicant	 	0.323	 	-0.055	0.505	7.16E-04	ATF4,CYBB,DDIT3,FOS,HIF1A,HMOX1,MAPT,NR4A2,TIMP1,TP53,UCP2,VCAM1	AGT,Ap1,EGR1,FOS,HIF1A,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARD,PPARG,RELA,SP1,SREBF1,STAT1,fatty acid,rotenone	
P2	 	SB203580	 	chemical - kinase inhibitor	Inhibited	-3.261	bias	-0.592	 	7.17E-04	ADIPOQ,ALPL,ANXA1,ARHGDIB,ATP5J2,C3AR1,CD83,CXCL10,CXCL9,DDIT3,EGR1,ENO1,ERP29,FAS,FOS,FOSB,FYB,GSTP1,HIF1A,HMOX1,HSPA5,IL1RN,ISG15,JUN,MAT2A,NQO1,NR4A1,PDGFA,PSMB4,RARRES3,SOCS3,SPP1,STAT1,STC2,TGFB2,THBS1,TIMP1,TP53,TRPA1,TYMP,UCP2,VCAM1,XYLT1	Ap1,CEBPA,CEBPB,EGR1,FOS,IFNG,IL1B,IRF8,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SB203580,SP1,STAT1,TNF	
P2	 	TNFRSF1B	1.322	transmembrane receptor	 	0.249	bias	0.410	-1.216	7.23E-04	ABCC3,CYP3A5,FAS,JUN,LEP,MBP,MSR1,NR5A2,P2RX7,PDGFA,SAA1,SOCS3,TIMP1,TYMP	AKT1,Ap1,CEBPB,FOS,FOXO1,IFNG,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,TNFRSF1B	
P2	 	simvastatin	 	chemical drug	 	-0.676	 	-0.164	0.022	7.39E-04	ADCYAP1R1,ANXA1,APOB,APP,ARHGDIA,ARHGEF2,CCND2,CD14,CYBB,CYR61,EDN1,FOS,HIST1H1C,HK1,HMOX1,ITGB2,KIT,MKI67,RAC1,SDC4,SOCS3,SPP1,ST6GALNAC4,STAT1,TIMM10,TIMP1,TNFRSF10B,VCAM1	CEBPA,CEBPB,CREBBP,CSF3,ERK1/2,FOS,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,simvastatin	
P2	 	TP63	-1.108	transcription regulator	Activated	3.405	bias	0.291	1.934	7.60E-04	ADRM1,ANOS1,ATG9A,CCND2,CCND3,CECR1,CSTA,CTSD,CYR61,DUSP10,DUSP6,ENG,FAS,FGFR2,FOS,G6PD,GAPDH,HAGH,HSPA7,HSPA8,INSR,IRF5,ITGA7,KCNG1,KRT10,KRT14,KRT6A,KRT6B,PI3,PIK3R3,POLD2,PRNP,RAP2A,S100A2,S100A7,S100A8,SH2B3,SLC7A11,THBS1,TMBIM6,TNFRSF10B,TP53,TPP1	AHR,ARNT,EP300,ERK,FOS,GATA1,HIF1A,Hdac,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),NR3C1,NRG1,RB1,RELA,SP1,STAT1,TP53,TP63,TP73,VHL,estrogen receptor	
P2	 	NFYA	1.191	transcription regulator	 	1.320	bias	0.529	 	7.96E-04	COL5A3,EGR1,EPHX1,FGFR2,FTH1,GADD45B,HLA-DQB1,HLA-DRA,HSPA5,HSPA7,JUN,PKM,SCD,THRSP,TOP2A	 	
P2	 	SIM1	2.916	transcription regulator	Activated	3.900	bias	0.694	 	8.08E-04	AGER,AKR1B1,AOX1,APOE,CCR1,CFL2,EGR1,EIF5A,FCGR2A,GALNT4,GLUL,HLA-A,ICMT,IGFBP4,KRT5,LCP1,LEP,MRPL37,MSC,MTPN,NACA,NAP1L4,NDUFA1,OAZ1,PDLIM4,PEA15,PFN1,TYROBP,UBA1	 	
P2	 	GNE	1.042	kinase	Inhibited	-2.000	bias	-0.309	-1.382	8.29E-04	ASNS,CHAC1,DDIT3,TRIB3	 	
P2	 	KDM3A	-1.273	transcription regulator	 	1.000	bias	0.309	0.382	8.29E-04	EDN1,GDF15,HMOX1,LEP	 	
P2	 	MRPL12	2.354	other	 	-1.982	bias	0.721	 	8.29E-04	MT-CO2,MT-ND1,MT-ND2,MT-ND6	 	
P2	 	Muscarinic cholinergic receptor	 	group	 	-0.837	bias	0.721	 	8.29E-04	ALPL,CYR61,FOS,JUN	Ap1,CREB1,CREBBP,ERK1/2,FOS,JUN,Mapk,Muscarinic cholinergic receptor,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,dopamine,estrogen receptor,nitric oxide	
P2	 	raclopride	 	chemical drug	 	-1.109	bias	0.721	 	8.29E-04	FOS,NR4A1,NR4A2,SDHB	CREB1,FOS,NFkB (complex),dopamine,estrogen receptor,raclopride	
P2	 	HMGA1	3.571	transcription regulator	 	-0.616	 	0.200	-1.520	8.44E-04	ALPL,CCND2,CITED1,CRYAB,CYR61,DAB2,DDIT3,EGR1,FOS,IGFBP4,INSR,KIT,KRT10,MAPKAPK2,MAPT,MGAT1,MVD,PHLDA2,RAN,RPL7A,SDC4,TRIM28	Ap1,CEBPA,CEBPB,EGR1,ELK1,ESR1,FOS,FOXO1,HMGA1,Ins1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RB1,RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	Ifn gamma	 	complex	 	1.222	bias	0.417	-0.360	8.48E-04	CXCL10,CXCL16,CXCL9,CYBB,EDN1,FAS,GBP1,IGFBP4,IL17RA,LGALS9,MAP4K4,PSME1,SOCS3,STAT1,TGFB2,VSIG4	CEBPB,CREBBP,IFNG,IRF8,Ifn gamma,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,RNA polymerase II,SP1,SPI1,STAT1,TNF	
P2	 	bufalin	 	chemical reagent	 	-0.816	 	-0.240	-0.228	8.51E-04	DDIT3,EGR1,FOS,HSPA5,RPLP0,TNFRSF10B,YWHAG,YWHAH	AHR,Ap1,CREBBP,EIF2AK3,ERK,ERK1/2,FOS,FOXO1,FOXO3,JUN,NFE2L2,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,bufalin	
P2	 	targinine	 	chemical drug	 	0.053	 	-0.025	0.120	8.51E-04	ADIPOQ,FAS,FOS,HLA-DRA,HMOX1,ITGB2,SOD1,VCAM1	ARNT,Ap1,CEBPA,D-glucose,FOS,FOXO1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SP1,STAT1,TNF,nitric oxide,targinine	
P2	 	methyl methanesulfonate	 	chemical toxicant	 	-0.178	bias	0.685	 	8.67E-04	BTG2,CTSD,DDIT3,EGR1,GADD45B,JUN,KLF4,PHLDA3,PLXNB2,TP53	Ap1,EGR1,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP63,TP73,methyl methanesulfonate	
P2	 	caffeic acid phenethyl ester	 	chemical drug	 	-1.058	bias	-0.539	 	8.80E-04	CD83,CTSB,CXCL10,DDIT3,EGR1,FCGRT,FTH1,FTL,HMOX1,HSPB1,LEP,MKI67,NFE2L2,NQO1,PTGFR,TP53,VCAM1	AHR,Ap1,CREBBP,EGR1,FOS,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,caffeic acid phenethyl ester,nitric oxide	
P2	 	bucladesine	 	chemical toxicant	 	1.223	bias	0.409	-1.209	8.85E-04	ABCA3,AIP,ANXA1,APOE,ASS1,C3AR1,CD14,CHST2,CXCL10,CYP3A5,DGKQ,DMD,FCER1A,FCGR2A,FOS,GADD45B,GDF15,GLUL,GSTP1,HMOX1,ITGB2,JUN,KIT,LEP,MAT2A,NCAM1,NR4A1,NR4A2,ODC1,PDE8B,QSOX1,SIGMAR1,SLC1A2,SLC9A3R1,SOCS3,SYP,TGFB2,TIMP1	Ap1,CEBPB,CREB1,CREBBP,FOS,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),Pde,Pka,RELA,SP1,STAT1,TNF,bucladesine,cyclic AMP	
P2	 	NCSTN	2.672	peptidase	 	-1.667	bias	-0.400	-0.465	8.94E-04	APP,CD14,CD68,CSF1R,CTSG,FCER1G,FCGR2A,GRN,S100A1	APP,FOS,HIF1A,NCSTN,NFKBIA,NFkB (complex),STAT1	
P2	 	A23187	 	chemical reagent	 	-0.079	bias	0.449	-1.915	8.95E-04	CD14,CD83,CYCS,DDIT3,DVL3,EGR1,FGF2,FOS,FOSB,HSPA5,JUN,MSR1,NR4A1,ODC1,S100A2,THRSP,TP53,TPO	A23187,Ap1,CEBPB,CREB1,EGR1,FOS,FOXO1,Insulin,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,cyclic AMP	
P2	 	ethanol	 	chemical - endogenous mammalian	Activated	2.795	 	0.206	1.568	9.01E-04	ACKR3,ADAM17,ADCYAP1R1,ADIPOQ,C3AR1,CBR1,CD14,CYP3A5,CYP4A11,DDIT3,DUSP6,EDN1,EGR1,EPHX1,FAS,FOS,FOSB,GDE1,HIF1A,HLA-A,HMOX1,HSPA5,IL1RN,JUN,MAP1B,MAT2A,MBP,NQO1,PHLDA2,PLIN1,PPP1R1B,PRKRA,SCD,SLC1A2,SLC40A1,SLC7A11,STAT1,STIM1,TGFB2,TIMP1,TLR8,TP53,VCAM1	Ap1,CEBPB,EGR1,FOS,IFNG,IKBKB,IRF8,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,TP53,ethanol	
P2	 	potassium chloride	 	chemical drug	 	-1.218	bias	0.511	 	9.07E-04	ATP2B1,BTG2,CIDEA,DDIT3,EGR1,FOS,HSPA5,JUN,NR4A1,NR4A2,ODC1,PIK3R1,PIM3,SPP1,UNC5B	Ap1,CEBPA,CREB1,CREBBP,CREM,CTNNB1,FOXO1,FOXO3,IL1B,INS,Insulin,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,Pkc(s),RELA,SP1,STAT5B,potassium chloride	
P2	 	Endothelin	 	group	 	-0.218	bias	0.721	 	9.21E-04	APP,CD74,EDN1,FOS,JUN,MAPT	Ap1,EGR1,Endothelin,FOS,JUN,Jnk,Mapk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,nitric oxide	
P2	 	NCAM1	-2.265	other	 	-0.128	bias	0.551	 	9.21E-04	GLUL,HSPA4,NCAM1,NLGN1,SYP,THBS1	 	
P2	 	tacrolimus	 	chemical drug	 	-1.572	 	-0.227	-0.495	9.23E-04	APP,CXCL10,CXCL9,CYBB,DCX,EDN1,EGR1,FKBP5,FLNA,FOS,FOSB,JUN,MAF,NME1,NR4A1,ODC1,PLIN2,PRKACB,PRNP,PTPRJ,SDC3,SDCBP,SIAH2,SPP1,TMEFF1,TNFRSF12A,TRPM6	Ap1,CREB1,CREBBP,EGR1,ERK1/2,FOS,FOXO1,Insulin,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,TP53,tacrolimus	
P2	 	STAT5B	-1.124	transcription regulator	 	-0.638	 	0.180	-1.417	9.30E-04	AKR1C1/AKR1C2,AKR1C3,CCND2,CCND3,CIDEA,CYP3A5,DGAT2,ESR2,FAS,FOS,HEXA,LEP,MAF,ME1,NR4A2,PIP,RASD1,SCD,SH3RF3,SOCS3,THRSP,TPM3,TRAF3,WARS	AKT1,CEBPA,CEBPB,CREBBP,FOXO1,IGF1,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),PRL,RELA,SP1,STAT1,STAT5B	
P2	 	HGF	-1.318	growth factor	 	1.872	bias	0.526	 	9.43E-04	ACKR3,ARPC5,ASNS,BMP2K,CALM1 (includes others),CD28,CNBP,CRYAB,CYR61,DDIT3,DOK5,DSG1,DTYMK,DUSP4,DUSP6,DYNLL1,EDN1,EGR1,FKBP5,FLNA,FOS,FOSB,GBA,HDGF,HK1,HMOX1,IGFBP4,ISG15,LGMN,MAPKAPK2,MAT2A,MKI67,MPC1,NR4A1,NR4A2,NR5A2,PDGFA,PGAM1,PHLDA2,PLPP1,RAC1,SFRP1,SLC1A2,SLC7A1,SLC9A3R1,SOCS3,SPP1,STAB1,TGFB2,THBS1,TIMP1,TNFRSF10B,TP53,VCAM1,YWHAH	Ap1,CREBBP,EGR1,ELK1,ERK1/2,FOS,HGF,JUN,Jnk,MAPK3,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53	
P2	 	NFAT (complex)	 	complex	 	-0.254	bias	0.561	 	9.46E-04	AIF1,CD68,CYGB,NR4A1,SLC1A2,SLC1A3,SPP1	 	
P2	 	NR2E1	-4.534	ligand-dependent nuclear receptor	 	 	 	 	 	9.46E-04	DCX,HRAS,MAP4K4,MAPK10,PLCE1,TGFB2,TGFBR1	 	
P2	 	RNA polymerase II	 	complex	 	 	 	 	 	9.82E-04	ADIPOQ,ALAS1,ALPL,ASNS,ATP13A2,CCND2,CD14,CD4,CD83,DCTPP1,DDIT3,ENO1,FOS,GADD45B,GAPDH,GDF15,GOT1,HLA-DQA1,HOXA7,IL1RN,KPNA2,MINOS1,NR5A2,OSGIN1,PCDHAC2,RPL12,RPS21,SDHC,SOCS3,SORBS1,SPP1,TXN,WDR36	MYC,NFKBIA,RNA polymerase II,SP1,TP53,TP63,TP73	
P2	 	PPP3CA	-1.195	phosphatase	 	 	 	 	 	9.86E-04	APP,CRYAB,FTL,GRN,GSTP1,LAMP2,LITAF,PRDX5,PSAP,PTGFR,SDC4,SPP1,STS	JUN,NFKB1,NFKBIA,NFkB (complex),PPP3CA,RELA,STAT1	
P2	 	decitabine	 	chemical drug	Activated	2.538	bias	0.547	 	9.90E-04	ABCC1,ABCC3,ANXA2,APOE,ARHGDIB,BTG3,CCND2,CCND3,COMT,CXCL10,CYP3A5,CYP4B1,DNASE1L3,EEF1B2,ESR2,FAS,FECH,FLNC,GADD45B,GDF15,GLB1,GSTP1,HSPB8,ISG15,ITGAV,KLF4,MAF,MKI67,NME1,NQO1,PDLIM4,PLCE1,RPL26,RPL37,RPL4,RPS13,RRM2B,S100A2,SFRP1,SLC19A1,SLC1A2,SNCG,SOCS3,SPP1,STAT1,TGFB2,TGFBR1,THBS1,TMSB10/TMSB4X,TOP2A,TP53,UBA1,UCHL1,WHSC1	Ap1,CDKN2A,CREBBP,EGR1,ELK1,ESR1,HIF1A,IRF8,JUN,MYC,NFKBIA,NFkB (complex),RB1,RELA,SP1,STAT1,TP53,TP63,TP73,YY1,decitabine	
P2	 	Jnk	 	group	 	0.828	bias	0.514	 	9.98E-04	AGER,ANXA5,APP,CD209,CD83,DDIT3,EDN1,EGR1,FAS,FOS,FOSB,GDF15,HMOX1,HSPA5,JUN,MRC2,MT-CO2,NFE2L2,NQO1,NR4A1,SESN2,SOCS3,TIMP1,TNFRSF10B,TNFRSF12A,TP53,VCAM1	CEBPA,CEBPB,IFNG,IL1B,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	CDKN2A	-3.731	transcription regulator	 	-0.375	 	-0.076	0.051	1.01E-03	AK1,BARD1,BTG2,BTG3,CAPG,CCND3,CCNI,CXCL10,CXCL14,DYNLRB1,EGR1,FBL,FMN2,FOS,GABARAP,GLB1,GNL3,GSPT1,IL2RG,ITGAV,JUN,LAMP1,MKI67,ODC1,P4HA2,PDGFA,POLD2,PTX3,RAB9A,RRM2B,SAE1,SLBP,TP53,TPP1,TRIM28	AHR,CDKN2A,CREBBP,E2F1,EGR1,ERK,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RB1,RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	EP300	1.057	transcription regulator	 	0.746	bias	0.601	 	1.02E-03	ADAM12,ADIPOQ,BANK1,CAMK2D,CAPG,CCND3,CD160,CD53,COMT,CRISPLD2,DUSP4,EDN1,EGR1,EYA2,FTH1,GM2A,GNG2,HLA-G,HMOX1,IL10RA,IL17RA,ITGB2,JUN,KCTD1,KRT14,LEP,MAF,MAFG,MCF2L,MKI67,NPAS2,NR4A1,NTRK3,PDGFA,PDLIM4,PLAA,PPFIBP2,RGL1,RNF157,SDC4,SLC7A11,SOCS3,TGFB2,TGFBR1,TNFRSF10B,TP53,TPO,WNT5B	ARNT,Ap1,CREB1,CREBBP,E2F1,EP300,FOS,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53,VHL,estrogen receptor	
P2	 	mannose	 	chemical - endogenous mammalian	Inhibited	-2.236	 	0.240	-2.773	1.06E-03	ATF4,FOS,HSPA5,NR4A1,THBS1	Ap1,CDKN2A,CREB1,EGR1,EP300,FOS,FOXO1,IL6,Insulin,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,TNF,TP53,YY1,mannose	
P2	 	methylene blue	 	chemical drug	 	-0.152	 	-0.197	0.237	1.06E-03	APP,MAPT,MT-CO2,NQO1,TXNRD1	APP,FOS,HIF1A,NFKBIA,NFkB (complex),STAT1,methylene blue	
P2	 	RB1	1.348	transcription regulator	Activated	3.695	 	0.178	2.752	1.08E-03	ALPL,ATP6V1F,BARD1,BTG3,COA3,COX14,COX17,DYNLRB1,EGR1,FAS,FGF2,FOS,GHITM,GPS2,H1F0,HIST1H1B,HRAS,ICT1,KIT,KRT10,LACTB,MAF,MECR,MRPL17,NDUFA13,NDUFA2,NDUFA4,NDUFA6,NDUFA9,NDUFS4,NME1,PARK7,PGD,PTX3,SDHB,SDHC,SLBP,SRPRA,TGFB2,TP53,TPO,TUBG1,UQCRQ,VDAC1	AHR,AKT1,Ap1,CEBPA,E2F1,EGR1,ELK1,ERK,ESR1,FOXO1,JUN,MYC,NFKB1,NFkB (complex),RB1,RELA,SP1,STAT1,TP53,VEGFA	
P2	 	TGM2	1.627	enzyme	Activated	2.403	bias	0.310	0.751	1.09E-03	ALPL,BTG2,CD74,CSRNP1,CXCL10,DAPK2,FARSB,FCER1G,GM2A,HIF1A,IL10RA,LGALS9,NLRC4,NPC2,PLEKHO2,POR,RARRES3,RFLNB,S100A8,SDCBP,SIRPA,SLC7A2,SLFN5,SMPD1,SPP1,STAT1,THBS1,TP53,TYROBP,VSIG4	ATP,CEBPB,CTNNB1,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,PRKCA,RELA,RNA polymerase II,STAT1,TGM2,TP53	
P2	 	propofol	 	chemical drug	 	-1.555	bias	-0.480	-0.310	1.11E-03	ANXA1,CD14,CYBB,EGR1,FOS,HMOX1,SOD1,THBS1,TP53	AHR,ARNT,Ap1,CREB1,D-glucose,EGR1,ERK,FOS,HIF1A,JUN,Jnk,MYC,NFKB1,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,dopamine,estrogen receptor,propofol	
P2	 	DCN	-1.101	other	 	-0.476	 	-0.060	-0.281	1.13E-03	CXCL10,ENG,FGF2,HIF1A,HLA-DQA1,HLA-DQB1,ITGAV,KIT,THBS1,TP53,VCAM1	AKT1,CEBPA,DCN,EGR1,FOXO1,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB1,TNF	
P2	 	MAPKAPK2	2.269	kinase	 	0.947	bias	0.353	-0.135	1.13E-03	CXCL10,DDIT3,HSPA5,HSPB1,HSPB8,LMO4,MSR1,RILPL1,TOP2A,TP53,VCAM1	EGFR,EGR1,FGF2,FOXO1,HIF1A,HTT,IL6,JUN,MAPKAPK2,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TSC2	
P2	 	cyclic AMP	 	chemical - endogenous mammalian	 	0.898	bias	0.458	-1.553	1.20E-03	APP,ASS1,CCND2,CRYAB,CYCS,DDIT3,EGR1,FGF2,FOS,GOT1,HIF1A,IGFBP4,IL1RN,INSR,JUN,LEP,LHCGR,NR4A1,NR4A2,ODC1,PER1,PFKFB1,PPP1R1B,PRNP,SOCS3,SOX9,SYP,TGFBR1,THRSP,TIMP1,TNFRSF10B,TP53,YWHAG	CEBPA,CEBPB,FOS,FOXO1,IL1B,IL6,Ins1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,TNF,cyclic AMP	
P2	 	CREM	-1.106	transcription regulator	Inhibited	-2.042	 	0.176	-2.716	1.22E-03	APOE,APOLD1,BTG2,CCND2,COL8A1,CSRNP1,DUSP4,EGR1,FOS,GADD45B,HLA-DRA,HMGCS1,HSPA4,IRAK1,MKNK2,MSMO1,NPC2,NR4A1,NR4A2,PER1,SIAH2,THBS1	CREB1,CREBBP,CREM,CTNNB1,EP300,Lh,NFE2L2,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,SREBF1,STAT1,cholesterol	
P2	 	salmonella minnesota R595 lipopolysaccharides	 	chemical - endogenous non-mammalian	Activated	2.083	bias	0.721	 	1.22E-03	ATP6V1E1,CD83,CXCL10,CXCL9,EGR1,FOS,FOSB,GDF15,HLA-DQA1,HLA-DRA,ISG15,JUN,MKI67,PTPRJ,SLC7A2,SLFN5,SOCS3,TPM3,VCAM1	Ap1,CREBBP,EGR1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,salmonella minnesota R595 lipopolysaccharides	
P2	 	cerivastatin	 	chemical drug	 	0.262	 	-0.066	0.427	1.25E-03	ASS1,FGF2,GNB1,HMGCS1,HMOX1,HSPB1,INSR,ITGB2,JUN,NR2F6,PDGFA,S100A8,TMSB10/TMSB4X,VCAM1	Ap1,CEBPA,EGR1,F2,FOS,IL1B,JUN,MYC,Mapk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,TP53,cerivastatin	
P2	 	lithium	 	chemical drug	 	-0.288	 	0.103	-0.641	1.25E-03	ADCY1,ADCY2,APP,CARM1,EGR1,FAS,FOS,ICMT,JUN,NCAM1,RAB7A,RET,SLC1A2,TP53	AHR,CEBPA,CREB1,CTNNB1,ERK,HTT,JUN,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TCF,TP53,lithium	
P2	 	TRPV4	1.020	ion channel	 	0.342	bias	0.601	 	1.25E-03	CXCL10,FAS,FOS,SOCS3,THBS1,TIMP1,VCAM1	ATP,IL6,JUN,NFKB1,NFkB (complex),NR3C1,RELA,RNA polymerase II,STAT1,TRPV4	
P2	 	SREBF1	1.704	transcription regulator	Activated	2.694	bias	0.475	0.902	1.26E-03	AACS,AARS,ADIPOQ,ATOX1,BHLHE41,CAPZB,CXCL10,DGKQ,FAS,G6PD,HMGCS1,HMOX1,HSPA13,HSPA5,LEP,MSMO1,MVD,PCK2,PIK3R3,PMVK,RPLP0,RPS24,SCD,STXBP1,THRSP,TP53,UCP2	AMPK,ARNT,CREB1,D-glucose,EGR1,FOXO1,FOXO3,HIF1A,Insulin,MYC,NFE2L2,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,PPARGC1A,RELA,SP1,SREBF1,STAT1,cholesterol,fatty acid	
P2	 	ARHGDIG	1.168	other	 	-1.633	bias	-0.721	 	1.30E-03	ALCAM,ANXA1,COL5A2,DUSP6,EDN1,OXLD1	 	
P2	 	BARX2	-4.305	transcription regulator	 	0.447	bias	0.601	 	1.30E-03	ANLN,DYNLL1,FLNA,HSPA9,NCAM1,TIMP1	 	
P2	 	Pkg	 	group	 	-0.816	bias	0.541	 	1.30E-03	EDN1,EGR1,FOS,FOSB,JUN,TXN	BDNF,CREB1,CREBBP,EDN1,EGR1,ELK1,ERK1/2,F2,FOS,JUN,MAP3K1,NFKB1,NFKBIA,NFkB (complex),NR3C1,Pkg,RELA,SP1,TP53	
P2	 	heme	 	chemical - endogenous mammalian	 	0.688	bias	0.270	0.109	1.30E-03	ALAS1,CYBB,FECH,HMOX1,PER1,SLC48A1	BACH1,NFE2L2,NFkB (complex),RELA,heme	
P2	 	thiazolidinedione	 	chemical drug	 	-1.709	bias	0.432	-2.744	1.30E-03	ADIPOQ,NR4A1,NR4A2,PIK3R1,SORBS1,UCP2	ARNT,CEBPA,CREB1,D-glucose,FOXO1,HIF1A,Insulin,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SP1,SREBF1,TNF,fatty acid,thiazolidinedione	
P2	 	ERBB4	-2.221	kinase	 	0.987	 	0.034	0.856	1.32E-03	BTG2,COL5A2,DDIT3,EGR1,GPAA1,GPC1,HIF1A,HMOX1,IGFBP4,JUN,SERPINE2,SFRP1,SOCS3,THBS1,TP53	AHR,Ap1,EGFR,ERBB2,ERBB4,ERK,FOXO1,HTT,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TP53	
P2	 	GDF2	 	growth factor	Activated	2.350	bias	0.651	 	1.32E-03	CRYAB,EDN1,ENG,FOS,GADD45B,HIF1A,HSPB8,HTRA1,NINJ1,PIM3,SEMA3C,SERPINE2,SLC3A2,SPP1,YWHAH	CREBBP,ERK1/2,FOS,GDF2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	HSF1	1.539	transcription regulator	 	-0.335	 	0.061	-0.601	1.33E-03	AHSA1,CBX3,CCT2,CCT5,CRYAB,CSRP2,FGF1,FKBP4,HMOX1,HSPA4,HSPA7,HSPA8,HSPB1,HSPH1,JUN,MAPT,MAT2A,MBOAT7,RAB5C,RARRES3,SLC5A3,STIP1,SYCE1,TRAF3,VCAM1	HSF1,HSF2	
P2	 	adenosine	 	chemical - endogenous mammalian	 	-0.092	 	0.058	-0.233	1.33E-03	AIFM2,CD28,FOS,HIF1A,HMOX1,HSPA5,ITGB2,NR4A2,SOCS3,TIMP1,TP53	Ap1,CEBPB,EGR1,FOS,IL6,JUN,Jnk,MYC,NFE2L2,NFKB1,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,adenosine,cyclic AMP	
P2	 	PP1	 	chemical - kinase inhibitor	 	-0.990	bias	-0.409	0.225	1.36E-03	CCND2,CXCL16,FOS,HMOX1,IL1RN,JUN,ODC1,SIRPA,VCAM1	Ap1,FOS,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PP1,RELA,SP1,SRC,STAT1	
P2	 	ESRRA	1.708	ligand-dependent nuclear receptor	 	1.760	bias	0.662	 	1.36E-03	ALAS1,CSRP2,CYCS,ENO1,GAPDH,GOT1,HK1,HMGCS1,LDHB,MINOS1,MTCH2,NDUFA1,NR1D1,PCK2,PKM,PLIN1	ESRRA,FOXO1,NRF1,PPARA,PPARD,PPARG,PPARGC1A	
P2	 	Pdgf (complex)	 	complex	 	-0.439	bias	0.432	-2.073	1.36E-03	CCND2,EDN1,EGR1,FGF2,FOS,FOSB,HIF1A,HMOX1,JUN,NCAM1,NR4A2,ODC1,PIK3R3,TIMP1,TP53,VCAM1	Ap1,CREBBP,EDN1,EGR1,ELK1,ERK1/2,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,Pdgf (complex),RELA,SP1,STAT1	
P2	 	prostaglandin J2	 	chemical - endogenous non-mammalian	Activated	2.804	bias	0.529	 	1.37E-03	GDF15,HMOX1,PSMA3,PSMA6,PSMB2,PSMB4,PSMB7,PSMD8	 	
P2	 	propylthiouracil	 	chemical drug	 	 	 	 	 	1.38E-03	ABCA3,ABCC3,AKR1C3,BTG2,CCND3,DCX,G6PD,GLUL,HCAR2,JUN,NNMT,NR4A1,NSMF,SLC1A2,SLC2A5,THRSP,TPO	JUN,RB1,RELA,TSH,propylthiouracil	
P2	 	FOXO3	-1.692	transcription regulator	 	-0.600	bias	0.305	-1.866	1.42E-03	CCND2,CLDN1,CXCL10,CYR61,DDIT3,DOK5,EGR1,FGFR2,FOS,FOSB,GADD45B,GLUL,IARS,MKI67,PRDX5,PRNP,SCO2,SLC1A4,SLC40A1,SLC7A1,SOD1,SREBF2,TGFB2,UCP2	AKT1,CTNNB1,E2F1,FOXO1,FOXO3,JUN,MXI1,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,TP63,TP73,Vegf	
P2	 	RUNX1	 	transcription regulator	 	1.057	bias	0.313	-0.179	1.45E-03	ALCAM,BTG2,CCND3,CD160,CD4,CD53,CPA3,CSF1R,CTSG,FAS,LCP2,MYL9,NCAM1,SLC24A3,SOX6,SPP1,TIMP1,TP53,TPSAB1/TPSB2,ZBTB16	AHR,Ap1,CREBBP,EGR1,ESR1,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,RUNX1,SP1,STAT1,estrogen receptor,progesterone	
P2	 	BLVRA	1.050	enzyme	 	 	 	 	 	1.47E-03	HMOX1,JUN,TNFRSF10B	 	
P2	 	CYP	 	group	 	 	 	 	 	1.47E-03	GCLM,HMOX1,NQO1	AHR,Ap1,CYP,EP300,NFE2L2,NFKBIA,NFkB (complex),RELA,STAT1,TP53,acetaminophen,benzo(a)pyrene	
P2	 	ENPP1	-1.367	enzyme	 	 	 	 	 	1.47E-03	ALPL,LEP,SPP1	 	
P2	 	TIAM1	-1.610	other	 	 	 	 	 	1.47E-03	JUN,RAC1,TIMP1	Ap1,EGR1,FOS,Jnk,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TIAM1	
P2	 	asparagine	 	chemical - endogenous mammalian	 	 	 	 	 	1.47E-03	ASNS,OAZ1,ODC1	 	
P2	 	ticrynafen	 	chemical drug	 	 	 	 	 	1.47E-03	GCLM,HMOX1,NQO1	 	
P2	 	TCF	 	group	 	 	 	 	 	1.49E-03	ADGRG2,ALDH3A2,CRAT,EGR1,EPHB3,F13A1,FOS,HTRA1,KRT5,LHCGR,PCCA,PCSK6,SAA1,SEMA3C,SLC1A5	CEBPA,CTNNB1,JUN,MYC,NFkB (complex),TCF,TP53	
P2	 	5-N-ethylcarboxamido adenosine	 	chemical reagent	 	-0.834	 	-0.034	-0.696	1.54E-03	ACKR3,BTG2,CES1,DAD1,EGR1,FGF2,HIF1A,HLA-DQA1,HLA-DQB1,HLA-DRA,HMOX1,NR4A1,NR4A2,ODC1,RAC1,SOCS3,THBS1	5-N-ethylcarboxamido adenosine,CEBPB,CTNNB1,FOXO1,FOXO3,IL6,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,Vegf,cyclic AMP	
P2	 	WT1	-5.976	transcription regulator	 	-0.249	 	0.119	-0.791	1.54E-03	APLP2,APRT,ARL2,ASNS,ATP5I,BTG2,CSF1R,CXCL10,EGR1,FGF1,FOSB,INSR,KLF4,KPNA1,NCSTN,NME1,NR4A2,ODC1,PCK2,PDGFA,PIR,RPL19,SOX9,SQSTM1,SREBF2,TARS,THBS1,TYROBP,WARS,YARS	CEBPA,CEBPB,FOXO1,IGF1,JUN,SP1,WT1	
P2	 	ursodeoxycholic acid	 	chemical - endogenous mammalian	 	0.306	 	0.192	-0.324	1.56E-03	ABCC3,CXCL10,CYP4A11,DDIT3,GCLM,MAF,MAFG,PDGFA,SPP1,TGFB2,TIMP1,TP53	Ap1,BACH1,CEBPB,CREBBP,ERK1/2,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,cyclic AMP,nitric oxide,ursodeoxycholic acid	
P2	 	P1,P4-Di(adenosine-5') tetraphosphate	 	chemical - endogenous mammalian	 	1.131	bias	0.721	 	1.56E-03	KIT,TGFB2,THBS1,TPSAB1/TPSB2	MITF,P1,P4-Di(adenosine-5') tetraphosphate,SPI1	
P2	 	PNPLA8	-1.025	enzyme	 	0.422	 	0.000	0.422	1.56E-03	HMOX1,HSPA5,NQO1,PLA2G2A	ARNT,Ap1,CEBPB,D-glucose,DDIT3,EGR1,FOS,FOXO1,HIF1A,Jnk,MYC,NFkB (complex),PNPLA8,PPARA,PPARG,RELA,SP1,SREBF1,arachidonic acid,palmitic acid	
P2	 	TOP1	1.625	enzyme	 	1.940	bias	0.721	 	1.56E-03	ASNS,GLB1,HIF1A,TP53	MYC,NFKBIA,SP1,TOP1,TP53,TP63,TP73,topotecan	
P2	 	acetic acid	 	chemical - endogenous mammalian	 	-1.955	bias	0.541	 	1.56E-03	EGR1,FOS,JUN,LEP	AHR,ERK,JUN,RELA,SP1,STAT1,acetic acid	
P2	 	acrylamide	 	chemical toxicant	 	 	 	 	 	1.56E-03	FOS,JUN,NCAM1,TP53	 	
P2	 	aristolochic acid I	 	chemical toxicant	 	 	 	 	 	1.56E-03	AGER,FOS,HMOX1,LEP	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,aristolochic acid I	
P2	 	carnosol	 	chemical - endogenous non-mammalian	 	1.944	 	0.000	1.944	1.56E-03	GCLM,HMOX1,NFE2L2,TP53	AKT1,Ap1,BACH1,EGR1,FOS,FOXO1,HMOX1,IKBKB,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,RELA,SP1,STAT1,TP53,carnosol	
P2	 	diltiazem	 	chemical drug	 	 	 	 	 	1.56E-03	CYP4A11,EDN1,FOS,JUN	CREB1,NFKB1,NFkB (complex),PRKCE,PRL,RELA,SP1,STAT1,STAT5B,diltiazem	
P2	 	EGFR	1.080	kinase	 	1.356	bias	0.287	-0.267	1.56E-03	ANXA1,C12orf49,CMA1,COL5A2,COL8A1,CRYAB,CXCL10,DDIT3,DUSP4,EGR1,ESR2,FOS,GAS5,GBP1,GPC1,GRN,HIF1A,HNRNPK,HOXA7,HSPA5,HSPB1,IGFBP4,JUN,PPIA,PSMB2,PSMB4,PSMB6,PSMB7,S100A2,SERPINE2,SFRP1,SOCS3,SOX9,THBS1,TNXB,TUBB4B,TUBG1	Ap1,CREBBP,CTNNB1,EGF,EGFR,EGR1,ERBB2,ERBB4,ERK1/2,FOS,JUN,KRAS,MYC,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53	
P2	 	MAP3K1	1.560	kinase	 	0.476	bias	0.519	 	1.57E-03	CSTA,EGR1,FAS,FOS,HMOX1,HSPB1,JUN,THBS1,TIMP1,TOP2A,TP53	AHR,Ap1,EGR1,ELK1,ERK,FOS,JUN,Jnk,MAP3K1,MAPK3,Mek,NFKB1,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53	
P2	 	methylselenic acid	 	chemical reagent	 	0.816	 	-0.209	1.329	1.59E-03	ACKR3,ACSL3,AKR1C1/AKR1C2,ALDH3A2,ATF5,CDC14B,CDK16,DDIT3,DTYMK,DUSP10,DYNLL1,EPHX1,ESR2,FKBP5,G3BP2,GDF15,H1F0,JUN,KLF4,MAP1B,MAPK9,MAPT,MAZ,MKI67,NQO1,PFDN5,SCD,TAF6,TOP2A,TUBB4B,UXS1,ZBTB16	 	
P2	 	leupeptin	 	chemical - protease inhibitor	Activated	2.200	bias	0.601	 	1.62E-03	APP,CD151,GBA,HRAS,MAPT	APP,FOS,HIF1A,NFKBIA,NFkB (complex),STAT1,leupeptin	
P2	 	nelfinavir	 	chemical drug	Activated	2.185	bias	-0.388	3.033	1.62E-03	ADIPOQ,ATF4,DDIT3,PLIN1,TNFRSF10B	NFkB (complex),PPARA,PPARD,PPARG,SREBF1,fatty acid,nelfinavir	
P2	 	dibutyl phthalate	 	chemical toxicant	 	-0.164	 	0.157	-0.573	1.63E-03	CYP4A11,FOS,JUN,NFE2L2,POR,SPP1,SREBF2	AHR,CEBPA,CEBPB,ESR1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,RNA polymerase II,SP1,STAT1,TP53,dibutyl phthalate	
P2	 	cocaine	 	chemical drug	 	-0.512	bias	0.461	-2.576	1.66E-03	ADCY1,DYNLL1,EGR1,FGF2,FOS,FOSB,GADD45B,GNB1,HSPA4,JUN,MAPT,MKNK2,NACC1,NR4A1,PER1,PPP1R1B,PSAP,SIAH2,SIGMAR1,SLC1A2,STAT1,THBS1,TSPO,TUBB	AHR,CREB1,CREBBP,CREM,CTNNB1,ELK1,ERK,FOS,HTT,JUN,L-glutamic acid,MAPK3,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,cocaine	
P2	 	trichostatin A	 	chemical drug	 	0.044	bias	0.407	-2.639	1.67E-03	ADAMTS5,ADCY1,ALPL,APOE,ATP5I,CCND2,CD14,CD28,CLDN1,CPA3,CTPS1,CXCL10,CYBB,CYP3A5,CYP4B1,DNASE1L3,DPM2,DTYMK,ESR2,FAS,FOS,G6PD,HIF1A,HLA-DQB1,HLA-DRA,HMGCS1,IL10RA,KIT,KRT6B,LAGE3,LGMN,LHCGR,LMX1A,MAF,MAT2A,PLCE1,PRNP,PSMB2,SCAMP2,SCNN1B,SEMA3C,SFRP1,SFRP4,SGPL1,SIAH2,SLC1A2,SQSTM1,SREBF2,STMN2,STT3A,THBS1,THSD4,TIMP1,TMSB10/TMSB4X,TNFRSF10B,TOP2A,TP53,TRAF3,VCAM1,WHSC1,YWHAH	AHR,CDKN2A,CEBPB,CREBBP,IFNG,IL6,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,decitabine,trichostatin A	
P2	 	sulindac sulfide	 	chemical drug	 	0.084	 	-0.106	0.448	1.72E-03	APP,ARPC1B,DYNLL1,EGR1,GARS,GDF15,MSMO1,NQO1,PGAM1,PIK3R1,RRM2B,STC2,TNFRSF10B	APP,ATF6,Ap1,EGR1,FOS,HIF1A,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PSEN1,PTGS2,RELA,STAT1,TP53,sulindac sulfide	
P2	 	fenofibrate	 	chemical drug	Activated	2.288	 	0.197	1.415	1.73E-03	ADIPOQ,APOB,APP,ASNS,CSF1R,CYP4A11,EDN1,GAPDH,GBE1,GLUL,GOT1,HADHB,HIF1A,HMOX1,HOXA7,JUN,KPNA1,LDHB,NACC1,PIK3R3,PLTP,POR,PSMA4,PTPRC,SCD,SLCO2B1,SREBF2,TP53,TPP1,UCP2,VCAM1	Ap1,CREB1,FOS,FOXO1,HIF1A,Insulin,JUN,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,STAT1,THRB,fenofibrate,reactive oxygen species	
P2	 	1-methyl-4-phenylpyridinium	 	chemical toxicant	 	0.913	bias	0.417	-0.085	1.78E-03	ATF4,DDIT3,HIF1A,SOD1,TP53,TRIB3	1-methyl-4-phenylpyridinium,26s Proteasome,EIF2AK3,ERN1,ESR1,FOXO1,FOXO3,HTT,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,TP53,VHL,XBP1,iron	
P2	 	CETP	1.116	enzyme	 	-0.218	 	-0.240	0.358	1.78E-03	APOB,APOE,DDIT3,HSPA5,PLIN1,PLIN2	CETP,CREB1,FOXO1,Insulin,JUN,LDL,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SREBF1,cholesterol	
P2	 	hydroxypropyl-beta-cyclodextrin	 	chemical drug	 	-1.673	bias	-0.266	-1.039	1.78E-03	CD68,CTSB,CTSD,NPC2,SQSTM1,SREBF2	 	
P2	 	epigallocatechin-gallate	 	chemical drug	 	0.387	bias	-0.257	1.603	1.79E-03	APOB,APP,BHLHE41,CXCL10,CYR61,DAPK2,EDN1,EGR1,FAS,FOS,FOSB,GADD45B,GJB2,HIF1A,HMOX1,ISG15,ITGAV,JUN,LAMP1,LEP,MKI67,NFE2L2,SFRP1,STAT1,TIMP1,TNFRSF10B,TOLLIP,TP53,VCAM1	AHR,Ap1,EGR1,ERK,FOS,IL6,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,epigallocatechin-gallate	
P2	 	aldesleukin	 	biologic drug	Activated	2.530	bias	0.657	 	1.79E-03	EIF5A,FCGR2A,FCGR3A/FCGR3B,GLUL,HLA-DRA,HLA-G,IFI30,IGKC,PSMB6,STAT1	 	
P2	 	Vegf	 	group	 	1.510	bias	0.526	 	1.80E-03	ACKR3,ALOX5AP,ASNS,BMP2K,CALM1 (includes others),CLDN1,CPA3,CRYAB,CXCL10,CYP4A11,CYR61,DDIT3,DOK5,DTYMK,DUSP4,DUSP6,EDN1,EGR1,ETV5,FAS,FGF2,FKBP5,FLNA,FOSB,GJB2,HIF1A,HMOX1,IGFBP4,MAPKAPK2,MAZ,MIF,MKI67,MPC1,NPL,NR4A1,NR4A2,NR5A2,NRROS,PDGFA,PHLDA2,PIK3CG,PLPP1,PPP1R1B,RAC1,RAMP3,RNF187,SFRP1,SLC7A1,SLC7A2,SLCO2B1,SOCS3,TIMP1,TNFRSF10B,VCAM1	Ap1,CEBPA,CREBBP,EGR1,ELK1,ERK1/2,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RAF1,RELA,SP1,STAT1,TGFB1,Vegf	
P2	 	actinomycin D	 	chemical drug	 	-1.485	bias	-0.487	1.032	1.81E-03	APP,ARHGEF26,ASS1,CD28,CYR61,DUSP4,EDN1,FAS,FLNA,FOS,FTH1,GAPDH,GSTP1,HIF1A,HK1,HMOX1,IGFBP4,JUN,PFKFB3,PTX3,RRM2B,SCNN1B,SDC3,SLC40A1,SOCS3,SPP1,TNFRSF10B,TP53	Ap1,EGR1,FOS,HSF1,JUN,Jnk,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SOD1,SP1,STAT1,TNF,TP53,TP63,TP73,actinomycin D	
P2	 	topotecan	 	chemical drug	 	-0.440	bias	-0.265	0.841	1.82E-03	ARPC1B,CD83,EGR1,ENG,ENO1,FAS,FOSB,GDF15,HIF1A,HLA-DQA1,HNRNPK,HSPA8,KCNMA1,MAT2A,NINJ1,NLGN1,PRNP,PTPRK,RAB9A,SESN2,SLC7A5,STK39,TOP2A,TP53,XPO6	AMPK,EGR1,FOXO3,MYC,NFKBIA,PPARGC1A,SP1,STAT1,TOP1,TP53,TP63,TP73,topotecan	
P2	 	BIRC5	-1.730	other	 	 	 	 	 	1.83E-03	C1QC,CD53,CD74,COL5A2,COL8A1,DPT,HLA-DQA1,HLA-DQB1,IL2RG,LYZ,TP53	BIRC5,MYC,NFKBIA,SP1,TP53,TP63,TP73	
P2	 	BRD4	1.287	kinase	Activated	2.712	bias	0.695	 	1.89E-03	CCND2,CCR1,CD4,DCTPP1,FOS,HMOX1,MTHFD1L,MTMR2,NME1,NQO1,SFXN4,SLC19A1,SLC7A2,SRM,STC2	 	
P2	 	losartan potassium	 	chemical drug	 	-1.322	bias	-0.444	0.482	1.89E-03	ATF4,CYBB,EDN1,EGR1,ENG,FOS,HSPA5,ITGAV,MAPT,PDGFA,SOCS3,SPP1,TGFB2,TGFBR1,TIMP1,UCP2,VCAM1	AGT,CEBPA,CREBBP,EGR1,ERK1/2,FOS,HIF1A,IL1B,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TGFB1,losartan potassium	
P2	 	resiquimod	 	chemical drug	 	1.740	bias	0.448	0.094	1.92E-03	AIF1,ATP5J,ATP6V1B2,CD83,CXCL10,FAS,FGF2,GDF15,GM2A,GNG2,HSPB1,IRAK1,JUN,KCNMA1,PARK7,PKM,PSMB2,PSMB4,PTX3,RAB7A,SPP1,TLR8,WARS	CEBPA,CEBPB,CREBBP,IFNG,IL10,IL1B,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,resiquimod	
P2	 	TP73	-1.552	transcription regulator	 	1.950	bias	0.263	0.379	1.93E-03	ABCC1,ADAM17,BTG2,CCND3,CD83,COL5A2,CRYAB,CTSD,CYR61,DDIT3,EGR1,FAS,FGF2,G6PD,GAB2,HAGH,HSPB8,IGFBP4,IRF5,KIT,KRT10,LCP1,LYZ,NCAM1,NLRC4,NUPR1,PIK3R3,POLD2,RRM2B,S100A2,SERPINE2,SPP1,THBS1,TIMP1,TNFRSF10B,TNFRSF12A,TP53,TPP1,TREM2	Ap1,CREBBP,EGR1,FOS,HIF1A,JUN,Jnk,MYC,NFKBIA,NFkB (complex),NR3C1,RELA,SNAI1,SP1,TP53,TP63,TP73	
P2	 	miR-1-3p (and other miRNAs w/seed GGAAUGU)	 	mature microrna	Inhibited	-4.292	bias	-0.721	 	1.96E-03	ANXA2,AP3D1,ATP6V1B2,C12orf49,CERS2,CHST11,CLCN3,EML4,EPB41L4B,G6PD,KIF2A,KLHL42,LARP4,MRC2,POLR2K,PREX1,RAB11FIP2,SDC4,SH3BGRL3,SHTN1,SLC25A1,SLC25A22,THBS1,TMSB10/TMSB4X,TPM3,XPO6	 	
P2	 	(+)-MK-801	 	chemical drug	 	1.560	 	0.127	1.128	1.96E-03	ALDOA,APP,EGR1,FGF2,FOS,FOSB,HSPA5,JUN,NPTXR,RAC1,STXBP1,TIMP1,TP53	(+)-MK-801,AHR,Ap1,CREB1,CREBBP,EGR1,ERK,ERK1/2,FOS,HTT,JUN,Jnk,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	methamphetamine	 	chemical drug	 	-0.619	bias	0.263	-1.469	1.96E-03	ABCC1,EGR1,FAS,FOS,FOSB,HMOX1,JUN,NR4A1,PCLO,SIGMAR1,SLC1A2,TXN,VCAM1	CEBPA,CREB1,CREBBP,CREM,CTNNB1,FOXO1,HIF1A,HTT,IL1B,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,methamphetamine,reactive oxygen species	
P2	 	Hsp70	 	group	 	-0.956	bias	0.256	-1.629	1.99E-03	CD14,CD83,GAPDH,HIF1A,HRAS,MAPT,SCNN1B,TYROBP,VCAM1	ATP,CREBBP,HTT,Hdac,Hsp70,IL10,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),NR3C1,P38 MAPK,PPARG,RELA,RNA polymerase II,SP1,STAT1,TP53	
P2	 	3,4,5,3',4'-pentachlorobiphenyl	 	chemical toxicant	 	1.604	bias	0.319	0.482	2.06E-03	CA3,CCND2,CES1,COMT,CYCS,EPB41L3,GSTP1,HSPA2,ITGA7,JUN,NQO1,PTGFR,SLCO2B1,TMSB10/TMSB4X	3,4,5,3',4'-pentachlorobiphenyl,Ap1,ESR1,FOS,JUN,NFkB (complex),NR3C1,PGR,SP1,STAT1,estrogen receptor,progesterone	
P2	 	N-cor	 	group	 	-1.195	bias	-0.633	 	2.06E-03	ADIPOQ,BIN1,CCR1,CXCL10,CXCL14,G6PD,GSTP1,LHPP,PLIN1,PLIN2,RGL1,SCD,STMN2,XYLT1	CEBPA,ESR1,FOXO1,JUN,N-cor,NFKB1,NFKBIA,NFkB (complex),NR3C1,PGR,PPARA,PPARG,RELA,RXRA,SP1,SREBF1,TNF,estrogen receptor,progesterone	
P2	 	diazoxide	 	chemical drug	 	-0.137	 	-0.240	0.487	2.09E-03	CYCS,EGR1,HYOU1,LEP,ODC1,SLC39A6,UCP2	ADIPOQ,ARNT,CEBPA,CEBPB,CREB1,CTNNB1,D-glucose,EGR1,FOS,FOXO1,HIF1A,Ins1,Insulin,JUN,LEP,MYC,NFKB1,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT5B,diazoxide	
P2	 	epoxomicin	 	chemical - protease inhibitor	 	1.412	bias	0.649	 	2.09E-03	DDIT3,DMD,H2AFZ,HSPA5,PSMA6,PSMB4,SQSTM1	26s Proteasome,CREBBP,ESR1,HTT,Hdac,NFE2L2,NFKB1,NFKBIA,PPARG,SP1,STAT1,TP53,epoxomicin	
P2	 	xanthohumol	 	chemical - endogenous non-mammalian	 	0.447	bias	-0.524	 	2.09E-03	ANXA1,DGAT2,FOS,GAB2,HMOX1,NQO1,TNFRSF10B	JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,xanthohumol	
P2	 	PLN	-1.018	transporter	 	 	 	 	 	2.13E-03	AK1,ALDH3A2,ALDOA,ANXA2,ATP2B1,ENO1,HRAS,RAB10,SOD1,SPTB,VCP	 	
P2	 	TSH	 	complex	 	0.874	bias	0.466	-0.623	2.13E-03	CCND3,CTSS,EGR1,ERP29,FOS,FTH1,GAPDH,IL1RN,INSR,SOCS3,TPO	CEBPB,CREB1,CREBBP,EGR1,HRAS,JUN,LEP,MYC,NFKBIA,NFkB (complex),PPARG,Pde,Pka,RELA,SP1,STAT1,STAT5B,TP53,TSH,cyclic AMP,phorbol myristate acetate	
P2	 	di(2-ethylhexyl) phthalate	 	chemical toxicant	Inhibited	-2.247	 	0.249	-3.048	2.13E-03	CCND2,CYP4A11,EGR1,FOS,FOSB,JUN,LHCGR,POR,SLCO2B1,SOD1,TSPO	AHR,ARNT,Ap1,CREB1,CREBBP,D-glucose,HIF1A,HSF1,JUN,Lh,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SOD1,SP1,SREBF1,STAT1,TP53,di(2-ethylhexyl) phthalate	
P2	 	MITF	1.177	transcription regulator	Activated	3.716	bias	0.647	 	2.15E-03	ALCAM,APEX2,APOE,APOLD1,ATP6V1B2,CD151,CLCN7,CMA1,CTSG,FOS,GM2A,HIF1A,HMBS,KAZN,KIT,MBP,MGAT4B,MMS19,OSTM1,PIR,RRAGD,SEMA3C,SHTN1,SLC14A1,SOX6,SOX9,ST3GAL6,STXBP1,TPSAB1/TPSB2,VAT1	Ap1,GATA1,IRF8,JUN,MITF,SPI1,TP53	
P2	 	Ifn	 	group	Activated	2.776	bias	0.488	0.999	2.26E-03	CD83,CFH,CXCL10,CYP4A11,EDN1,FAS,FOS,HIF1A,HLA-A,IL10RA,ISG15,PTPRJ,RARRES3,S100A8,SPP1,STAT1,TP53,TYMP	Ap1,CREBBP,EGR1,FOS,IRF8,Ifn,JUN,Jnk,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT1,TP53,TP73,cisplatin	
P2	 	PRKAA2	-1.898	kinase	Inhibited	-2.141	bias	-0.313	-0.941	2.32E-03	ALAS1,ARHGDIB,CIDEA,CYBB,CYP3A5,DDIT3,DUSP4,EGR1,ERN1,FGFR2,HIF1A,HSPA5,IGFBP4,LEP,LMO4,MT-CO1,TP53	AHR,AMPK,CEBPB,CREBBP,DDIT3,EGR1,FOXO1,FOXO3,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARGC1A,PRKAA2,RELA,SP1,STAT1,VEGFA,palmitic acid	
P2	 	miR-30c-5p (and other miRNAs w/seed GUAAACA)	 	mature microrna	Inhibited	-3.172	bias	-0.721	 	2.32E-03	JUN,MAP4K4,MAT2A,MPDU1,NPR3,P4HA2,PAFAH1B2,PTPA,PTPRK,SLC38A1,SLC7A1,SLC7A11,TMED3,TMEM41B,TNFRSF10B,TP53,UBE2I	 	
P2	 	SB-431542	 	chemical reagent	 	-0.851	bias	-0.270	0.115	2.32E-03	CD14,DVL3,FOLR2,FOS,GADD45B,GJB2,GJB6,PTPRK,SLC1A2,SPP1,TGFB2,TGFBR1,TNFRSF12A,XYLT1	AKT1,Cg,EGR1,ESR1,ESR2,FOXO1,NFKBIA,NFkB (complex),NR3C1,PGR,RELA,SB-431542,SP1,SP3,STAT1,beta-estradiol,estrogen receptor,progesterone	
P2	 	KITLG	1.094	growth factor	 	1.802	bias	0.583	 	2.34E-03	AIF1,ALOX5AP,ATP6V1B2,BZW2,CCND3,CD14,CD68,CIAPIN1,CMA1,CREG1,EGR1,FOS,FTH1,HMOX1,IL1RN,ITGAV,KIT,KPNA2,LAPTM5,MS4A2,PKM,RCC2,RPLP0,RPS23,SDHC,STIM1,TPSAB1/TPSB2,TXNL1,UCP2	Ap1,CREBBP,FOS,IL6,IRF8,JUN,KIT,KITLG,NFKB1,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1	
P2	 	SURF1	2.426	enzyme	 	-0.447	bias	-0.721	 	2.36E-03	INSR,MT-CO1,MT-CO2,NDUFA1,VDAC1	 	
P2	 	pyruvic acid	 	chemical - endogenous mammalian	 	0.651	bias	0.412	-0.261	2.36E-03	ALDOA,FOS,NR4A1,TNFRSF10B,TP53	AHR,ARNT,CEBPB,CREB1,DDIT3,EP300,ERK,FOXO1,HIF1A,Insulin,JUN,MYC,NFKB1,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,TP53,VHL,palmitic acid,pyruvic acid	
P2	 	NRG2	1.403	growth factor	 	 	 	 	 	2.37E-03	ARPC4,BIN1,CCND3,CYR61,EDN1,EGR1,FOSB,HMOX1,NR4A1,PDGFA,PFKFB1,TGFBR1	CREBBP,ERBB2,ERBB4,ERK1/2,FOS,MYC,NFKBIA,NFkB (complex),NRG2,RELA,SP1,STAT1,TP53	
P2	 	IL27	-2.665	cytokine	Activated	3.086	bias	0.341	1.636	2.39E-03	CCND2,CCND3,CD14,CD63,CD74,CXCL10,CXCL9,EGR1,FOS,HLA-A,HLA-DQA1,HLA-DQB1,HLA-DRA,IL1RN,MAF,RARRES3,SOCS3,STAT1,VCAM1	CEBPB,CREBBP,IFNG,IL10,IL27,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	ETS	 	group	 	 	 	 	 	2.39E-03	C3AR1,DAB2,EGR1,ENG,FOS,TIMP1	 	
P2	 	PD184352	 	chemical drug	 	 	 	 	 	2.39E-03	EGR1,FOS,HSPA5,NELFB,PPP1R14B,TRMT112	Ap1,CREBBP,E2F1,EGR1,ELK1,ERK1/2,FOS,FOXO3,HIF1A,JUN,Jnk,MAPK3,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD184352,PRKAA2,RELA,SP1,STAT1,TP53	
P2	 	peoniflorin	 	chemical drug	 	0.757	 	0.144	0.411	2.39E-03	ENO1,GLO1,HMOX1,PPP1R1B,PSMB7,TUBB	 	
P2	 	wortmannin	 	chemical - kinase inhibitor	 	-1.507	bias	-0.358	0.236	2.45E-03	CCND2,CCND3,CD14,CIDEA,CXCL10,CXCL16,DDIT3,DSG1,EGR1,FOS,GSTP1,HIF1A,HMOX1,INSR,JUN,LEP,MAF,MSR1,NFE2L2,NR4A1,OGT,SOCS3,TP53,TYMP,VCAM1	AGT,AKT1,Ap1,FOXO1,HIF1A,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),RELA,SP1,STAT1,TNF,wortmannin	
P2	 	Pln	 	other	 	 	 	 	 	2.47E-03	AK1,ALDH3A2,ALDOA,ANXA2,ATP2B1,ENO1,HRAS,RAB10,SOD1,SPTB,VCP	 	
P2	 	JAK2	1.055	kinase	 	0.075	bias	0.594	 	2.48E-03	ACTN1,AKR1C3,CCND2,CXCL10,CYBB,EGR1,FGF2,FOS,MYL12A,ODC1,PFN1,PHLDA3,SLC1A3,SOCS3,SPTB,STAT1,THBS1,TP53	AHR,CREBBP,ERK,ERK1/2,FOS,IRF8,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	ADIPOQ	-2.334	other	 	-1.007	 	0.099	-1.378	2.48E-03	ACSM5,ADIPOQ,CXCL10,CXCL9,CYBB,EGR1,ESR2,FOS,HMOX1,LEP,LHCGR,MSR1,PFKFB1,PRDX5,SCD,SYP,TIMP1,TP53,UCP2,VCAM1	ADIPOQ,AKT1,FOXO1,HIF1A,IL6,JUN,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,reactive oxygen species	
P2	 	guanidinopropionic acid	 	chemical - endogenous non-mammalian	Activated	3.157	bias	0.721	 	2.49E-03	ALAS1,ATP5G1,CYCS,NDUFA1,NDUFA11,NDUFA12,NDUFB2,NDUFB4,NDUFS4,SDHB	 	
P2	 	IRAK4	-1.422	kinase	 	1.980	bias	0.400	1.187	2.53E-03	APP,BTG2,CSRNP1,CXCL10,CXCL16,DAB2,EDN1,EGR1,FOS,FOSB,IRF5,JUN,NR4A1	AHR,Ap1,CREBBP,EGR1,ERK,ERK1/2,FOS,IRAK4,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	temozolomide	 	chemical drug	Activated	2.234	 	0.070	2.040	2.60E-03	CXCL10,CXCL9,DDIT3,FAS,ITGAV,MT-CO2,TNFRSF10B,TP53	AHR,CREBBP,FOS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTGS2,RB1,RELA,SP1,STAT1,TP53,TP63,TP73,temozolomide	
P2	 	CFTR	-2.010	ion channel	 	-0.266	 	-0.057	-0.079	2.61E-03	ASNS,CAPG,CFH,CPA3,CUBN,CYP3A5,CYP4A11,FAS,POR,S100A8,SAA1,SCD,SOCS3,STAT1	Ap1,CFTR,CREBBP,FOS,IRF8,JUN,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,STAT1	
P2	 	PDLIM2	1.046	other	 	-1.291	 	-0.031	-1.170	2.64E-03	CLCN4,CRISPLD2,FOXRED2,GNG2,KIT,MYEOV,MYL9,NPR3,PHLDA3,SLC40A1,SRGAP1,STAT1,STC2,SUSD3,TNS1	 	
P2	 	fatty acid	 	chemical - endogenous mammalian	 	0.432	bias	0.518	 	2.64E-03	CIDEA,CYR61,DDIT3,HMOX1,HSPA5,NR4A1,NR4A2,PLIN2,PLIN5,S100A8,SCD,THRSP,TNFRSF10B,UCP2,VCAM1	Ap1,CEBPA,CEBPB,CREB1,DDIT3,FOXO1,Insulin,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,Pkc(s),RELA,RXRA,SREBF1,cholesterol,fatty acid,palmitic acid	
P2	 	vitamin K3	 	chemical drug	 	1.320	bias	0.605	 	2.65E-03	ABCC1,DDIT3,EGR1,FAS,FOS,HMOX1,HSPA5	ATF6,Ap1,DDIT3,EGR1,FOS,FOXO1,FOXO3,Jnk,MAP2K1/2,MYC,NFKBIA,NFkB (complex),RELA,SP1,TP53,TP63,TP73,vitamin K3	
P2	 	AP3B1	1.179	transporter	 	 	 	 	 	2.65E-03	AP3D1,CD63,LAMP1,LAMP2	 	
P2	 	Ck2	 	complex	 	-1.067	 	0.080	-1.226	2.65E-03	ATF4,CYBB,FOS,INSR	APP,CDKN2A,CTNNB1,Ck2,EP300,FOS,FOXO1,FOXO3,HIF1A,HMGA1,IRS1,JAK2,MYC,NFKB1,NFKBIA,NFkB (complex),SP1,STAT1,TP53,TP63,TP73,YY1	
P2	 	IREB2	1.365	translation regulator	 	-1.960	bias	-0.400	-1.175	2.65E-03	APP,FTH1,FTL,SDHB	HTT,IREB2,NFE2L2,VHL,iron	
P2	 	MEMO1	2.188	other	 	-0.192	bias	0.721	 	2.65E-03	CTSD,FOS,JUN,STC2	AHR,Ap1,CREBBP,ERK1/2,ESR1,ESR2,FOS,JUN,MEMO1,MYC,NFKBIA,NFkB (complex),RELA,SP1,TP53,estrogen receptor	
P2	 	NEK7	1.011	kinase	Activated	2.000	bias	0.400	1.199	2.65E-03	CXCL10,EDN1,ISG15,LMO4	 	
P2	 	PTGES3	1.232	enzyme	 	0.594	bias	0.561	 	2.65E-03	ABCC3,CTSD,HIF1A,NUPR1	AHR,ESR1,NFkB (complex),PTGES3,RELA,SP1,TP53	
P2	 	Pde	 	group	 	0.000	bias	-0.561	 	2.65E-03	FOS,HMOX1,NR4A1,NR4A2	AHR,CEBPB,ERK,JUN,NFkB (complex),Pde,RELA,SP1,STAT1,cyclic AMP	
P2	 	mir-194	 	microrna	 	 	 	 	 	2.65E-03	RAC1,SLC7A5,THBS1,TP53	 	
P2	 	raltitrexed	 	chemical drug	 	1.960	bias	0.721	 	2.65E-03	ANXA2,FAS,TMSB10/TMSB4X,TP53	CREBBP,IRF8,JUN,NFKBIA,NFkB (complex),STAT1,raltitrexed	
P2	 	KLF3	1.124	transcription regulator	 	-1.947	 	-0.216	-0.618	2.67E-03	ANXA5,APOE,APRT,ARPC4,ATF4,BCAP29,CAMK2D,CAPG,CAPNS1,CHCHD10,CTNNA1,DEGS1,EIF5A,EPRS,FAM49A,FCGRT,FOS,GPR137,GSTP1,HIST1H2AC,HLCS,HPS1,IL17RA,MIF,MTCH2,MYO5A,NELFB,NSMAF,PSMB2,PSMD7,RAB7A,RNF167,SLC14A1,SPTB,SUSD3,TPM3,TRAPPC1,TYROBP,WSB1	 	
P2	 	isoproterenol	 	chemical drug	Activated	2.118	bias	0.457	0.202	2.71E-03	ACSL3,ADIPOQ,APP,EDN1,FGF2,FOS,HMOX1,JUN,LEP,NR4A1,ODC1,PDGFA,PLIN2,PRNP,RAB5C,RAB7A,SCD,TIMP1,TUBB,UCP2	CEBPB,CREB1,CREM,EGR1,FOXO1,HTT,JUN,L-glutamic acid,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,cyclic AMP,forskolin,isoproterenol	
P2	 	methylmercury	 	chemical toxicant	 	1.155	 	0.100	0.809	2.71E-03	ACVR1C,ATF5,CD63,EGR1,HMOX1,MAPKAPK2,MTPN,NR2F6,PDCL3,RAB9A,RTN4,SLC9A3R1	CREB1,FOS,NFkB (complex),dopamine,estrogen receptor,methylmercury	
P2	 	RETN	-4.250	other	 	-0.137	bias	0.409	-1.275	2.85E-03	EDN1,FOS,HMOX1,INSR,SCD,SOCS3,SPP1,TRAF3,VCAM1	ARNT,CREBBP,CTNNB1,D-glucose,ERK1/2,FOS,HIF1A,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,PTEN,RELA,RETN,SP1,STAT1,STAT5B,TNF	
P2	 	phenacetin	 	chemical drug	Activated	2.155	bias	0.652	 	2.85E-03	ANXA1,ANXA2,CAPN6,GAS5,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A	NFKBIA,NFkB (complex),PTGS2,TP53,phenacetin	
P2	 	benzene	 	chemical toxicant	 	0.905	 	0.075	0.657	2.85E-03	ACVR1C,ATF5,CD63,EGR1,MAPKAPK2,MTPN,NR2F6,PDCL3,RAB9A,RTN4,SLC9A3R1	 	
P2	 	hemin	 	chemical - endogenous mammalian	Activated	2.229	bias	0.427	0.852	2.85E-03	AKR1C1/AKR1C2,CYBB,FTH1,FTL,GSTP1,HMOX1,HSPA7,JUN,NFE2L2,NQO1,TXN	Ap1,BACH1,CREB1,CREBBP,FOS,FOXO1,Insulin,JUN,NFE2L2,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,STAT1,TP53,hemin,hydrogen peroxide	
P2	 	trichloroethylene	 	chemical toxicant	 	0.905	 	0.075	0.657	2.85E-03	ACVR1C,ATF5,CD63,EGR1,MAPKAPK2,MTPN,NR2F6,PDCL3,RAB9A,RTN4,SLC9A3R1	 	
P2	 	TNFSF11	-7.907	cytokine	Activated	2.322	bias	0.569	 	2.87E-03	ADRA1A,AIF1,C3AR1,CAPN2,CCND3,CCR1,CD14,CD83,CSF1R,DAB2,FAS,FOS,GADD45B,GRN,HMOX1,IL1RN,ITGAV,JUN,KEAP1,PAG1,PDGFA,PHLDA3,POR,RGL1,SDC4,SEL1L,SIGMAR1,SOCS3,SPP1,STAT1,VCAM1	Ap1,CEBPA,CHUK,CTNNB1,FOS,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TNFSF11	
P2	 	KIT	2.237	transmembrane receptor	 	 	 	 	 	2.94E-03	C3AR1,CCND2,CCND3,CD53,CD63,CMA1,CPA3,FCER1A,HMOX1,IL17RA,KIT,RAB32,SOCS3,SPP1,STAT1	Ap1,CREBBP,FOS,GATA1,IRF8,JUN,KIT,KITLG,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TNF,TP53,imatinib	
P2	 	probucol	 	chemical drug	 	-1.342	 	-0.240	-0.804	3.14E-03	CYBB,HMOX1,PSMA3,PSMA4,TP53,VCAM1	Ap1,CAV1,CTNNB1,EGR1,JUN,LDL,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,Sod,TP53,probucol	
P2	 	SUMO3	1.782	other	 	-1.912	 	-0.085	-1.689	3.16E-03	APP,CCND2,CXCL16,HLA-G,HMGA1,HSPA8,ISG15,LAMP3	 	
P2	 	5-azacytidine	 	chemical drug	 	1.940	bias	0.603	 	3.20E-03	ANXA2,CLDN1,CTNNA1,ESR2,ETV5,GDF15,GSTP1,HSPA5,HSPA8,KEAP1,LDHB,SLC3A2,SLC7A5,SLC9A1,SOCS3,SOX9,TGFBR1,THBS1,TNFRSF10B,TUBB	5-azacytidine,Ap1,EGR1,ELK1,ESR1,RNA polymerase II,SP1,SP3,TP53	
P2	 	alitretinoin	 	chemical drug	 	1.300	bias	0.326	-0.132	3.26E-03	ABCC3,ANXA5,APP,CCND3,CD14,CD83,CIDEA,CPM,CXCL10,CYCS,CYP4F11,DNASE1L3,FOLR2,FOS,HLA-DRA,ISG15,MKI67,PLTP,SCD,SPP1,WNT5B	Ap1,CEBPA,FOS,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,PPARGC1A,RELA,RXRA,SP1,STAT1,THRB,alitretinoin,nitric oxide	
P2	 	ALKBH5	1.452	enzyme	 	 	 	 	 	3.28E-03	ADGRG2,CTSD,EEF1D,HSPA8,LHCGR,MBP,RPLP0,SBF1,SLC4A2,SOD1,SOX6,STON1,TMBIM6,UBA1	 	
P2	 	S100A8	5.023	other	 	1.000	 	0.159	0.297	3.30E-03	ADAMTS5,ALPL,C1QB,CPM,CXCL10,CXCL14,CXCL9,EPB41L4B,ETV5,FAS,FCGR2A,GJB2,HMOX1,ISG15,KCNMA1,MCF2L,NTRK3,PDGFC,PER1,RNASE6,S100A8,SCUBE1,VCAM1	AHR,CEBPA,CEBPB,CREBBP,IL1B,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,S100A8,SP1,STAT1,TP53	
P2	 	arginine	 	chemical - endogenous mammalian	 	-0.226	 	0.133	-0.557	3.31E-03	DDIT3,EGR1,HIF1A,HSPA5,PCK2,SCD,SLC7A5	ARNT,CEBPA,CEBPB,D-glucose,EIF2AK3,FOXO1,FOXO3,HIF1A,IGF1,INS,JUN,LDL,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,STAT5B,TP53,arginine	
P2	 	butylated hydroxyanisol	 	chemical toxicant	 	0.651	bias	0.257	-0.001	3.31E-03	CBR1,FOS,GSTP1,JUN,NFE2L2,NQO1,SLCO2B1	Ap1,BACH1,CEBPA,CREB1,EGR1,FOS,IL1B,INSR,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,butylated hydroxyanisol	
P2	 	ROCK1	1.181	kinase	 	0.927	bias	0.618	 	3.33E-03	APP,CCND2,CCND3,EDN1,VCAM1	APP,ARNT,CREB1,CREBBP,D-glucose,ERK1/2,FOS,HIF1A,INSR,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,ROCK1,SP1,STAT1	
P2	 	SPTLC2	-1.098	enzyme	 	-1.432	bias	-0.529	 	3.33E-03	ATF4,DDIT3,HSPA5,THBS1,TIMP1	IL6,JUN,NFKB1,NFkB (complex),RELA,SPTLC2,STAT1	
P2	 	Sod	 	group	 	-1.000	bias	-0.515	 	3.33E-03	DSG1,HLA-DRA,HMOX1,TP53,VCAM1	Ap1,EGR1,FOS,FOXO1,HIF1A,HMOX1,IKBKB,Jnk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NRF1,RELA,SP1,STAT1,Sod,TP53,hydrogen peroxide,reactive oxygen species	
P2	 	epoprostenol	 	chemical - endogenous mammalian	 	-0.714	 	0.206	-1.165	3.33E-03	EGR1,FOS,HIF1A,RAC1,SPP1	CEBPB,JUN,NFkB (complex),RELA,STAT1,cyclic AMP,epoprostenol	
P2	 	fluoride	 	chemical - endogenous mammalian	 	1.969	bias	0.721	 	3.33E-03	DDIT3,FAS,FOS,HSPA5,VCAM1	CTNNB1,JUN,NFKBIA,NFkB (complex),PRKCA,RELA,fluoride	
P2	 	nimodipine	 	chemical drug	 	0.447	bias	-0.625	 	3.33E-03	CYP3A5,FOS,NR4A1,NR4A2,ODC1	BDNF,CREB1,EGR1,ELK1,FOXO1,Insulin,NFkB (complex),NR3C1,PPARA,PPARG,RELA,nimodipine	
P2	 	ABCB6	1.937	transporter	Inhibited	-2.913	 	0.050	-3.060	3.37E-03	CYP3A5,CYP4A11,CYP4B1,FECH,HAGH,HK1,HMBS,SLC25A39,UROS	 	
P2	 	GPX1	1.618	enzyme	Inhibited	-2.621	bias	-0.515	 	3.37E-03	AGER,CD14,CXCL10,CYBB,DUSP4,FAS,SOD1,TXN,VCAM1	Ap1,FOS,GPX1,JUN,LEP,MYC,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,SRC,STAT1,STAT5B,TP53	
P2	 	IKBKB	-1.183	kinase	Activated	2.648	bias	0.492	-0.036	3.43E-03	AGER,CCR1,CTSB,CXCL10,DUSP6,EDN1,EGR1,FAS,FOS,GM2A,GRN,HIF1A,HLA-A,HMOX1,IL1RN,ISG15,MAT2A,MBP,MYO1D,NAGLU,PLD3,PLIN1,PTX3,SEMA3C,SERPINE2,SFRP1,SOCS3,TGFBR1,TMEM176B,TP53,VCAM1	CEBPA,CHUK,CTNNB1,IKBKB,IKBKG,IL1B,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53	
P2	 	7S NGF	 	complex	 	 	 	 	 	3.48E-03	FOS,GCLM,NFE2L2	 	
P2	 	G6PC3	1.548	phosphatase	 	 	 	 	 	3.48E-03	ATF4,CYBB,DDIT3	EIF2AK3,FOXO1,FOXO3,G6PC3,NFE2L2,STAT1,TP53	
P2	 	GCLM	2.489	enzyme	 	 	 	 	 	3.48E-03	FOS,GCLM,JUN	 	
P2	 	HEPH	1.371	transporter	 	 	 	 	 	3.48E-03	CNTNAP1,RTN4,SLC40A1	 	
P2	 	PAPOLA	1.247	enzyme	 	 	 	 	 	3.48E-03	MT-ATP6,MT-CO1,MT-CO3	 	
P2	 	PDK4	-3.805	kinase	 	 	 	 	 	3.48E-03	HIF1A,PKM,RHEB	 	
P2	 	apamin	 	chemical toxicant	 	 	 	 	 	3.48E-03	FOS,JUN,VCAM1	Ap1,FOS,JUN,NFkB (complex),RELA,apamin,nitric oxide	
P2	 	aurothiomalate	 	chemical drug	 	 	 	 	 	3.48E-03	HMOX1,MT-CO2,NQO1	Ap1,EGR1,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,aurothiomalate,nitric oxide	
P2	 	ghrelin	 	biologic drug	 	 	 	 	 	3.48E-03	EGR1,FOS,SCD	Ap1,FOS,JUN,NFkB (complex),RELA,ghrelin,nitric oxide	
P2	 	lithium chloride	 	chemical drug	 	-0.573	bias	0.333	-1.840	3.53E-03	APP,ASS1,CD4,FOS,GDF15,HMOX1,MAPK10,MAPT,PER1,PLIN2,PTX3,RSPO1,SOX9,TMEM2,TNFRSF10B,TP53	AHR,AKT1,CREB1,CREBBP,FOXO1,Gsk3,HTT,L-glutamic acid,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53,lithium chloride	
P2	 	WNT1	-2.010	cytokine	 	0.711	bias	0.491	-0.836	3.58E-03	CCND2,CCND3,DNAJC1,EGR1,EIF5A,FOS,GRN,JUN,KIT,KRT5,KRT6B,LMX1A,PRKRA,RNASE1,SEMA3C,SIM1,SPP1,TP53	AHR,CEBPA,CTNNB1,ERBB2,ERK,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TCF,TP53,TP63,TP73,WNT1	
P2	 	STAT1	1.755	transcription regulator	Activated	2.067	bias	0.507	 	3.59E-03	APOE,CCND2,CCND3,CD14,CXCL10,CXCL9,CYP3A5,CYP4A11,EDN1,EGR1,FAS,FCER1G,FGF2,FOS,GBP1,HIF1A,HTRA1,IRF5,ISG15,JUN,PDGFA,PDGFC,PSMB10,PSME1,SLFN5,SOCS3,STAT1,TAPBPL,TLR8,TNFRSF10B,TP53,TYMP,WARS	CEBPA,CEBPB,CREBBP,ERK1/2,FOS,IFNG,IL1B,IRF8,Ifn,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,STAT4	
P2	 	amphetamine	 	chemical drug	 	-0.645	bias	0.396	-1.766	3.66E-03	ATF4,CSF1R,EGR1,FOS,FOSB,GNB1,HSPA4,HSPA8,JUN,PPP1R9B,STIP1,SYP,TP53,UCHL1	AKT1,CREB1,CREBBP,CREM,CTNNB1,ERK1/2,FOS,FOXO1,HTT,L-glutamic acid,NFKBIA,NFkB (complex),RELA,SP1,STAT1,amphetamine,dopamine,estrogen receptor	
P2	 	haloperidol	 	chemical drug	 	-1.233	bias	0.405	-2.638	3.66E-03	CCND3,DVL3,EGR1,FGF2,FOS,FOSB,HMGCS1,NR4A1,NR4A2,PER1,PPP1R1B,PPP1R9B,SDHB,SIGMAR1	ADCY,AKT1,Ap1,CREB1,CREBBP,CREM,CTNNB1,FOXO1,HTT,NFKB1,NFKBIA,NFkB (complex),Pde,Pka,Pkc(s),RELA,SP1,STAT1,haloperidol	
P2	 	SMARCA4	1.577	transcription regulator	Activated	4.185	bias	0.658	 	3.76E-03	ADIPOQ,ALDH2,ARHGDIB,ARRDC4,ASNS,ATG9A,BAMBI,BIN1,CCDC85B,CCR1,CD163L1,CD52,CD63,CD74,CPM,CTSB,CTSS,CYP4B1,DUSP4,DUSP6,EGR1,FADS3,FAS,FCGR2A,FGFR2,FOS,GAPDH,GBP1,GSTP1,GULP1,GYS1,HLA-DRA,HOXA7,IFI30,IGFBP4,IL20RB,ITGA7,ITGAV,JUN,KDM6B,KIFAP3,KIFC3,KIT,MAP1B,MT-ND2,NPC2,PHLDA2,PLIN2,PTX3,S100A2,SERPINE2,SLC40A1,SPP1,ST6GALNAC4,STXBP6,TAPBPL,TGFB2,TREM2,TUBB,TXNRD1	AHR,Ap1,E2F1,EGR1,ELK1,ESR1,ESR2,MYC,NFKBIA,NFkB (complex),RB1,RELA,RNA polymerase II,SMARCA4,SP1,SP3,TP53,TP63,TP73,estrogen receptor	
P2	 	testosterone	 	chemical - endogenous mammalian	 	0.845	bias	0.347	-1.236	3.80E-03	ADIPOQ,ALDOA,ANXA1,ATP2B1,ATP6V1F,CA3,CIZ1,CLCN3,EGR1,ESR2,FAM89B,FAS,FGFR2,FOS,FOSB,GPC1,HIF1A,HNRNPK,JUN,LEP,LHCGR,MT-CO1,MT-CO2,MT-CO3,MT-CYB,MT-ND5,NR5A2,ODC1,SLC9A1,SNRNP25,SRD5A1,TGFB2,TGFBR1,THBS1,TOP2A,TUBB2A,TXNRD1,VCAM1	Ap1,CEBPA,CEBPB,CREB1,ESR1,ESR2,FOS,FOXO1,IGF1,Insulin,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,RELA,SP1,STAT1,TP53,beta-estradiol,estrogen receptor,testosterone	
P2	 	HOXA9	-3.272	transcription regulator	 	0.000	bias	0.349	-0.697	3.82E-03	AHCYL1,ARF1,ARPC5,CLCN7,CSNK1A1,CTSG,CYBB,DHX8,FCGRT,JUN,KIT,LYZ,MAFG,PTPRC,RPL37A,RPS3A,S100A8,SDC4,SDCBP,SERINC2,SPP1,WSB1,YWHAG	CREB1,CREBBP,EP300,HOXA9,NFkB (complex),RELA,STAT1	
P2	 	2,3,4,7,8-pentachlorodibenzofuran	 	chemical toxicant	 	0.709	 	0.139	0.271	3.93E-03	CA3,CES1,COMT,CYCS,EPB41L3,HSPA2,ITGA7,NQO1,PTGFR,TMSB10/TMSB4X	2,3,4,7,8-pentachlorodibenzofuran,ESR1,NFkB (complex),NR3C1,PGR,estrogen receptor,progesterone	
P2	 	Gm-csf	 	group	 	-0.160	bias	0.615	 	3.93E-03	CCND2,CD14,CD209,CD83,FAS,FOS,IRAK1,JUN,LAMP3,SOCS3	Ap1,CEBPA,CREBBP,ERK1/2,FOS,Gm-csf,IL1B,IRF8,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PTPN11,RELA,SP1,SPI1,STAT1	
P2	 	mir-15	 	microrna	Inhibited	-2.188	bias	-0.549	 	3.93E-03	APP,CARM1,CCND2,FGF1,FGF2,HMGA1,LAMP1,TIMP1,TP53,UCP2	AHR,CREBBP,NFKB1,NFKBIA,NFkB (complex),RELA,mir-15	
P2	 	PGR	-1.073	ligand-dependent nuclear receptor	Activated	2.674	bias	0.464	0.303	3.95E-03	AHCYL1,AKR1C3,CAPN2,CCND3,CKAP4,COMT,CTSD,DYNLL1,EDN1,FAM49A,FAM89B,FKBP5,FOS,GLUL,GOT1,HIF1A,HPCAL1,HSPA2,KCNG1,KLF4,MAT2A,MBOAT7,MTSS1,P4HA2,PDGFA,PFKFB3,RAB9A,S100A8,SLC7A5,SLC9A1,SLC9A3R1,STAT1	CEBPA,CEBPB,CREBBP,ERK1/2,ESR1,FOS,JUN,NFKBIA,NFkB (complex),NR3C1,PGR,PRL,RELA,SP1,STAT1,STAT5B,TP53,dexamethasone,estrogen receptor,progesterone	
P2	 	ABCA1	1.235	transporter	 	-0.513	 	-0.144	-0.125	3.97E-03	ADIPOQ,ANXA1,APOB,APOE,APP,DGAT2,HSPA5,LEP,SREBF2	ABCA1,APOE,CEBPA,CREB1,CTNNB1,FOXO1,IL1B,IL6,Insulin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT1,cholesterol	
P2	 	baicalein	 	chemical - endogenous non-mammalian	 	0.000	bias	-0.474	1.328	3.97E-03	CCND3,CYBB,DDIT3,FOS,HMOX1,JUN,MT-CO1,TIMP1,VCAM1	AHR,Ap1,EGR1,ERK,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),Pkc(s),RELA,SP1,STAT1,baicalein	
P2	 	Pka	 	complex	 	-0.835	bias	0.370	-2.372	4.02E-03	APOE,CCND3,CD14,CXCL10,DDIT3,DUSP4,EDN1,EGR1,FOS,HMOX1,JUN,LEP,LHCGR,NR4A1,NR4A2,PPP1R1B,SLC1A2,SLC1A3,SOX9	AHR,Ap1,CEBPB,CREB1,CREBBP,FOXO1,Insulin,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARA,PPARG,Pka,RELA,SP1,STAT1,cyclic AMP	
P2	 	ritonavir	 	chemical drug	 	0.000	 	-0.144	0.285	4.02E-03	ADIPOQ,ALAS1,ATP2B1,C9orf72,CARS,CCND2,CFL1,CRYAB,CYP3A5,LEP,ME1,MSMO1,PCIF1,PNRC2,SCD,SREBF2,TRIM31,TSN,VCAM1	ADIPOQ,CEBPA,CEBPB,CTNNB1,DDIT3,EGR1,FOS,FOXO1,FOXO3,HMGA1,IRS1,Ins1,NFKB1,NFkB (complex),NR1I2,PPARA,PPARG,RELA,palmitic acid,ritonavir	
P2	 	GLP-1-(7-34)-amide	 	chemical drug	 	-1.105	 	0.034	-1.187	4.05E-03	AGER,FOS,HMOX1,NQO1,NR4A1,VCAM1	CEBPB,CREB1,CREBBP,CREM,CTNNB1,FOXO1,GLP-1-(7-34)-amide,Insulin,JUN,NFkB (complex),PPARA,PPARG,Pde,Pka,RELA,STAT1,cyclic AMP	
P2	 	Sch-23390	 	chemical drug	 	0.408	bias	-0.577	 	4.05E-03	EGR1,FAS,FGF2,FOS,FOSB,HSPA9	AHR,CREB1,CREBBP,ELK1,ERK,ERK1/2,FOS,HTT,JUN,L-glutamic acid,MAPK3,NFKBIA,NFkB (complex),RELA,SP1,STAT1,Sch-23390,TP53,dopamine,estrogen receptor	
P2	 	sucrose	 	chemical - endogenous mammalian	 	0.446	bias	0.388	-0.257	4.05E-03	APOE,APP,DDAH2,FOS,FOSB,LEP	ELK1,FOS,JUN,MAPK3,NFkB (complex),TP53,sucrose	
P2	 	mir-10	-2.371	microrna	Inhibited	-2.274	bias	-0.506	 	4.07E-03	ACVR1C,CYR61,GAB2,HIF1A,KLF4,MAF,MKNK2,PPP1CA,PSMD8,RAP2A,SGPL1,TGFBR1,TP53	MYC,NFKBIA,SP1,TP53,TP63,TP73,mir-10	
P2	 	CHADL	1.924	other	 	-0.378	 	-0.124	-0.049	4.09E-03	CRYAB,FAS,NTRK3,PDGFA,PTX3,SOX9,VCAM1	 	
P2	 	CA074-methyl ester	 	chemical reagent	 	-0.247	 	0.000	-0.247	4.16E-03	APP,CTSB,LAMP1,LAMP2	CA074-methyl ester,ERBB2,MYC,NFKBIA,SP1,STAT1,TP53	
P2	 	MAFF	-1.066	transcription regulator	Activated	2.000	bias	0.721	 	4.16E-03	ABCC3,GSTP1,NQO1,TXNRD1	 	
P2	 	MAPKAPK3	1.714	kinase	 	-0.849	 	-0.144	-0.563	4.16E-03	DDIT3,HSPA5,HSPB1,HSPB8	 	
P2	 	NCK1	1.254	kinase	 	-1.981	 	-0.080	-1.822	4.16E-03	ATF4,DDIT3,FOS,HSPA5	Ap1,CREBBP,EIF2AK3,ERK1/2,FOS,FOXO1,FOXO3,JUN,NCK1,NFE2L2,NFKBIA,NFkB (complex),RELA,STAT1,TP53	
P2	 	EZH2	2.240	transcription regulator	 	-1.092	 	-0.021	-1.002	4.18E-03	ACKR3,ALOX5AP,ALPL,CCND2,CCND3,CRISPLD2,CSNK1A1,CTNNA1,CXCL10,EGR1,FUCA1,GDF15,GPR26,HOXA10,HOXA7,HOXB5,IL10RA,KLF4,KRT6B,MAL2,PER1,PIP5K1C,RARRES3,SAA1,SAA2,SCAMP2,SFRP4,SGPL1,SLC1A3,SLC7A11,STT3A,TP53	CTNNB1,EZH2,MYC,NFkB (complex),RB1,TP53,WNT1	
P2	 	NRIP1	-2.151	transcription regulator	 	-0.213	bias	-0.414	1.023	4.29E-03	AIFM2,CIDEA,CYP4B1,GYS2,HADHB,LDHB,OTUB2,PTX3,SCD,SDHB,THRSP	 	
P2	 	glucocorticoid	 	chemical drug	 	0.394	 	0.069	0.045	4.34E-03	ANXA1,CCND3,CD2,CSF1R,CYP3A5,EDN1,FAS,G6PD,GLUL,GOT1,GRN,HMOX1,HRAS,IL10RA,IL1RN,INSR,KRT14,KRT5,LEP,MIF,NR4A2,ODC1,PER1,PFKL,PRNP,SOCS3,SPP1,TGFB2,TP53,VCAM1,ZBTB16	CEBPA,CEBPB,FOS,FOXO1,IFNG,IL6,IRF8,Ins1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,TNF,glucocorticoid	
P2	 	IRF4	-2.190	transcription regulator	Inhibited	-2.887	bias	-0.320	-1.546	4.43E-03	ALPL,ATF4,CD68,CTSS,CXCL10,CXCL9,DDIT3,GBP1,HSPA8,IL17RA,IL1RN,IRF5,ISG15,MAPK9,RAB7A,RAC1,RPS3A,SPP1,STAT1,YWHAH	CREBBP,IL10,IL4,IRF4,IRF8,JUN,NFAT (complex),NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF	
P2	 	bee venom	 	chemical - endogenous non-mammalian	 	-0.917	 	0.249	-1.696	4.43E-03	CYBB,DDIT3,FOSB,FYB,HSPB1,ITGAV,JUN,KLF4,LCP2,MKI67,NR4A2,NUPR1,SLC7A11,SOCS3,TOP2A	JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,TP53,bee venom	
P2	 	PSEN2	2.015	peptidase	 	-1.403	 	-0.054	-1.206	4.52E-03	APP,C1QA,C1QB,C3AR1,CD74,CTSS,GAPDH,GAS5,GNB1,INSR,KIF5B,STAB1,TNXB,TP53	APP,ATF6,FOS,HIF1A,JUN,MYC,NFKBIA,NFkB (complex),PSEN1,PSEN2,STAT1,TP53	
P2	 	chromium	 	chemical drug	Inhibited	-3.162	bias	-0.558	 	4.53E-03	ABHD4,AJUBA,ARHGDIA,DOK5,ENTPD5,G6PD,NQO1,PGD,SLC1A4,TAF6	 	
P2	 	iron	 	chemical - endogenous mammalian	 	1.590	 	0.092	1.308	4.53E-03	APP,CCND2,CCND3,DDIT3,FTH1,FTL,GADD45B,HIF1A,HMOX1,SLC40A1	AMPK,Ap1,EGR1,EP300,EPAS1,FOXO3,HIF1A,IL6,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARA,PPARG,PPARGC1A,RELA,STAT1,VHL,docosahexaenoic acid,iron	
P2	 	conjugated linoleic acid	 	chemical drug	 	0.137	 	0.051	0.003	4.55E-03	FOS,GDF15,IL10RA,IL1RN,ITGB2,LEP,SOCS3,TP53	ADIPOQ,AHR,CREBBP,CTNNB1,EGR1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,conjugated linoleic acid	
P2	 	ibuprofen	 	chemical drug	 	-1.086	 	-0.225	-0.554	4.55E-03	APP,CYBB,GDF15,HIF1A,PLIN2,PTPRC,RAC1,TNFRSF10B	AHR,APP,CREBBP,ERK1/2,FOS,HIF1A,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SREBF1,STAT1,ibuprofen	
P2	 	DIRAS3	1.609	enzyme	 	1.342	bias	0.541	 	4.56E-03	CAPN6,DNASE1L3,FOSB,HLA-DQA1,HMGA1	 	
P2	 	MXI1	1.249	transcription regulator	Inhibited	-2.219	bias	-0.721	 	4.56E-03	IARS,MKI67,ODC1,SLC1A4,SLC7A1	 	
P2	 	allyl sulfide	 	chemical drug	 	0.246	bias	0.270	-0.353	4.56E-03	ABCC3,CYP3A5,EPHX1,HMOX1,NFE2L2	 	
P2	 	PRKACA	1.506	kinase	 	-0.037	bias	0.510	 	4.65E-03	ADIPOQ,ALAS1,CCND2,CCND3,LEP,PRKACB,SFRP4,SOCS3,VCAM1	ATF4,CREB1,CREBBP,E2F1,EGR1,ELK1,EP300,ERK1/2,FOS,FOXO1,HIF1A,INSR,Mek,NFKBIA,NFkB (complex),NR1I2,PPARG,PRKACA,RELA,SP1,STAT1,TP53,estrogen receptor	
P2	 	vincristine	 	chemical drug	 	0.878	 	0.212	0.361	4.65E-03	EGR1,FAS,HNRNPK,JUN,LCP1,MAPK9,NCAM1,TP53,TUBB2A	Ap1,EGR1,ELK1,FOS,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RAF1,RELA,SP1,STAT1,TP53,TP73,doxorubicin,vincristine	
P2	 	DICER1	1.190	enzyme	 	0.457	 	-0.170	1.130	4.67E-03	ACVR1C,ARID3B,CAMK2D,CCND2,CYR61,EGR1,ENG,FOS,GNG2,GREB1L,JUN,LCP1,MAF,MT-ND5,NANOS1,PANK3,PIK3CG,RBM38,RET,SFRP4,SLC40A1,SOCS3,THBS1,TP53	Ap1,CREBBP,DICER1,EGFR,ERBB2,FOS,FOXO1,GATA1,HTT,IRF8,JUN,MYC,NFKBIA,NFkB (complex),RELA,SP1,SPI1,STAT1,TP53,TP63,TP73	
P2	 	CD38	-1.099	enzyme	Activated	3.619	bias	0.626	 	4.80E-03	ALDOA,ANXA2,ASNS,ASS1,CCND2,CISD1,CKAP4,CLCN3,FAM162A,GBE1,IFI30,LFNG,NCAM1,PDIA6,PFKL,PKM,PSAT1,SLC7A5,SOCS3,STK39,VCAM1	CD38,CEBPB,IFNG,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	SNAI1	1.640	transcription regulator	 	-1.477	 	-0.133	-1.181	4.88E-03	ACTN1,ACTR1A,ADIPOQ,AFAP1,CCND2,CCND3,CFL1,CFL2,CLDN1,FLNA,FLNC,FOS,MYO5A,PEBP1,TPM3	Ap1,EGR1,ELK1,ESR1,SNAI1,SP1,TP53	
P2	 	clofibrate	 	chemical drug	 	1.775	bias	0.364	0.396	4.88E-03	ABCC3,ACOT4,ANXA7,CCND2,CYP4A11,FAS,GSTP1,HADHB,HMOX1,IL1RN,NQO1,RTN4,SCD,SLCO2B1,UCP2	ACOX1,ATF6,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,RXRA,SREBF1,STAT1,clofibrate,oleic acid	
P2	 	PAX3	1.975	transcription regulator	 	1.154	bias	0.400	0.366	4.89E-03	ALDH3A2,ANOS1,ANXA1,APP,ARHGDIB,ASNS,ASS1,CD151,CTSA,EYA2,FHL1,FKBP1A,G0S2,G6PD,GLB1,MAPK9,NNMT,NPC2,PEA15,PPP1R2,PSME1,RET,TGFB2,TP53,YARS	MYC,NFKBIA,PAX3,SP1,TP53,TP63,TP73	
P2	 	trans-hydroxytamoxifen	 	chemical drug	 	0.791	 	-0.166	1.474	4.91E-03	ALDH4A1,DUSP4,EPB41L3,GSTP1,IFI30,IGFBP4,LHFPL2,LITAF,MAPT,SIAH2,SLC39A6,SMPD1,SNCG,SRD5A1,STXBP1,TGFB2,TOP2A	AHR,ESR1,ESR2,MYC,SP1,estrogen receptor,trans-hydroxytamoxifen	
P2	 	Nuclear factor 1	 	group	 	 	 	 	 	5.01E-03	ALAS1,ALDOA,DDIT3,FAM89B,GSS,SLC25A5,TP53	 	
P2	 	eplerenone	 	chemical drug	 	-1.968	bias	-0.529	 	5.01E-03	ADIPOQ,CD68,CYBB,EDN1,PDGFA,SPP1,VCAM1	CEBPA,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,eplerenone	
P2	 	proteasome inhibitor PSI	 	chemical - protease inhibitor	 	1.366	 	0.240	0.758	5.01E-03	DDIT3,FAS,HMOX1,HSPA5,NFE2L2,SQSTM1,TP53	26s Proteasome,AHR,ERK,ESR1,IL6,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,proteasome inhibitor PSI	
P2	 	PRKCE	1.535	kinase	 	0.931	bias	0.612	 	5.04E-03	ADAM12,APP,CCND3,CYR61,EGR1,FOS,HSPA5,IL2RG,JUN,ODC1,PDGFA,VCAM1	Ap1,CEBPA,CEBPB,CSF3,EGR1,FOS,FOXO1,FOXO3,JUN,Jnk,MAP2K1/2,MYC,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,PRKCE,Pkc(s),RELA,STAT1,TP53	
P2	 	EIF4E	-1.653	translation regulator	Activated	4.267	bias	0.721	 	5.13E-03	ATOX1,CAPG,CAPZB,CHMP1A,FGF2,GPS2,HIF1A,HMOX1,HRAS,IGFBP4,LSM10,LSM4,NHP2,ODC1,PRDX5,RHOG,SNRPA,TP53,UBE2A	 	
P2	 	PTGS2	-3.180	enzyme	 	1.867	bias	0.374	0.424	5.17E-03	ANXA1,ANXA2,CD68,CTSD,CXCL10,CXCL14,DYNLL1,EGR1,FOS,ITGAV,LEP,MAPK9,MKI67,MSR1,NR4A2,PIK3CG,RAC1,RPS19,RPS3A,TNFRSF10B,TP53	AKT1,Ap1,FOXO1,IL6,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARA,PPARG,PTGS2,RELA,SP1,STAT1,TNF,indomethacin	
P2	 	Ap1	 	complex	 	0.049	bias	0.650	 	5.17E-03	C3AR1,DDIT3,EDN1,FOS,GSS,GSTP1,HMBS,HMOX1,JUN,KRT6B,LHCGR,MSR1,MT-CO2,NQO1,PLA2G2A,RSPO3,SNCG,SPP1,TIMP1,VCAM1	Ap1,BCL6,CSF2,CTNNB1,EGR1,FOS,FOXO1,FOXO3,IL2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,Vegf	
P2	 	7beta-hydroxycholesterol	 	chemical - endogenous mammalian	 	 	 	 	 	5.33E-03	NR4A1,NR4A2	 	
P2	 	AGAP2	1.415	enzyme	 	 	 	 	 	5.33E-03	TP53,UNC5B	AGAP2,AKT1,FOXO1,NFkB (complex),RELA,SP1,STAT1	
P2	 	DST	-1.295	other	 	 	 	 	 	5.33E-03	DDIT3,HSPA5	 	
P2	 	DTNB	1.876	other	 	 	 	 	 	5.33E-03	DMD,SNTB1	 	
P2	 	ECE1	1.025	peptidase	 	 	 	 	 	5.33E-03	APP,EDN1	AHR,CREBBP,ECE1,NFKB1,NFKBIA,NFkB (complex),RELA	
P2	 	EIF2A	1.126	translation regulator	 	 	 	 	 	5.33E-03	ATF5,PCK2	ATF4,DDIT3,EIF2A	
P2	 	FBXO25	1.343	enzyme	 	 	 	 	 	5.33E-03	EGR1,FOS	ELK1,FBXO25,FOS,Hdac	
P2	 	GH2	2.831	other	 	 	 	 	 	5.33E-03	INSR,PIK3R1	CTNNB1,FOXO1,FOXO3,GH2,HMGA1,IRS1	
P2	 	GSTK1	1.286	enzyme	 	 	 	 	 	5.33E-03	ADIPOQ,DDIT3	 	
P2	 	IFI30	2.968	enzyme	 	 	 	 	 	5.33E-03	CTSS,HLA-A	 	
P2	 	IMPACT	1.412	other	 	 	 	 	 	5.33E-03	ATF4,DDIT3	 	
P2	 	KT 5926	 	chemical - kinase inhibitor	 	 	 	 	 	5.33E-03	CD14,VCAM1	 	
P2	 	LFM-A13	 	chemical - kinase inhibitor	 	 	 	 	 	5.33E-03	CCND2,HMOX1	IL10,IRF8,JUN,LFM-A13,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1	
P2	 	MRAP2	1.030	other	 	 	 	 	 	5.33E-03	LEP,MRAP	 	
P2	 	NAGLU	2.072	enzyme	 	 	 	 	 	5.33E-03	LYZ,MAPT	 	
P2	 	NCEH1	1.637	enzyme	 	 	 	 	 	5.33E-03	DDIT3,HSPA5	 	
P2	 	NMB	1.989	other	 	 	 	 	 	5.33E-03	FOS,JUN	EGR1,ELK1,JUN,MYC,NFkB (complex),NMB,PPARA,PPARG,RAF1,RELA,SREBF1,arachidonic acid	
P2	 	PLSCR3	1.887	enzyme	 	 	 	 	 	5.33E-03	ADIPOQ,LEP	 	
P2	 	PNKP	1.333	kinase	 	 	 	 	 	5.33E-03	MT-CO2,MT-CO3	 	
P2	 	RFX4	-3.167	transcription regulator	 	 	 	 	 	5.33E-03	HLA-DRA,RPL30	 	
P2	 	RPS19	2.304	other	 	 	 	 	 	5.33E-03	CD74,MIF	 	
P2	 	SVIL	-1.808	other	 	 	 	 	 	5.33E-03	ANLN,TP53	 	
P2	 	castanospermine	 	chemical reagent	 	 	 	 	 	5.33E-03	CNTNAP1,TPO	 	
P2	 	cation	 	chemical - other	 	 	 	 	 	5.33E-03	GSTP1,ITGB2	 	
P2	 	gimeracil	 	chemical drug	 	 	 	 	 	5.33E-03	CYP3A5,POR	 	
P2	 	ginkgolide A	 	chemical - endogenous non-mammalian	 	 	 	 	 	5.33E-03	CYP3A5,PRNP	 	
P2	 	miR-483-5p (miRNAs w/seed AGACGGG)	 	mature microrna	 	 	 	 	 	5.33E-03	ALCAM,ARHGDIA	 	
P2	 	olaparib	 	chemical drug	 	 	 	 	 	5.33E-03	FAS,TNFRSF10B	Ap1,EGR1,ELK1,ESR1,SP1,TP53,olaparib	
P2	 	tegafur	 	chemical drug	 	 	 	 	 	5.33E-03	CYP3A5,POR	 	
P2	 	teleocidins	 	chemical toxicant	 	 	 	 	 	5.33E-03	FOS,ODC1	 	
P2	 	verticillin A	 	chemical reagent	 	 	 	 	 	5.33E-03	FAS,TNFRSF10B	 	
P2	 	SRC	1.386	kinase	 	0.094	bias	0.329	-1.152	5.35E-03	CCND2,CTSB,CXCL10,ENO1,FMN2,FOS,GBP1,HIF1A,HMOX1,JUN,LAMP1,LAMP2,NFE2L2,NQO1,SIRPA,SPP1,VCAM1	AHR,Ap1,CREBBP,CTNNB1,ERK1/2,FOS,FOXO1,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PIK3R1,RELA,SRC,TP53	
P2	 	Mapk	 	group	 	-0.492	bias	0.641	 	5.38E-03	ADAM12,APP,CYBB,EGR1,FOS,HMOX1,JUN,LEP,PER1,S100A8,SNCG,SOD1,SPP1,STAT1,VCAM1	Ap1,CEBPA,CREB1,FOXO1,HTT,IL6,JUN,L-glutamic acid,MYC,Mapk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PI3K (complex),PPARA,PPARG,RELA,RXRA,SP1,STAT1	
P2	 	nitrofen	 	chemical toxicant	Inhibited	-2.121	bias	-0.721	 	5.40E-03	CLCN7,EGR1,ENO1,FGFR2,HK1,HYOU1,PLD3,RTN4	 	
P2	 	folic acid	 	chemical - endogenous mammalian	 	-1.093	 	0.123	-1.458	5.41E-03	ABCC1,APP,CERS6,CSNK1A1,JUN,SFRP1,TP53,UNG,VCAM1	APP,FOS,HIF1A,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1,folic acid	
P2	 	ERK	 	group	 	1.228	bias	0.447	-0.813	5.42E-03	ACTN1,AGER,BTG2,BTG3,CCND3,CCR1,CXCL10,EDN1,EGR1,FAS,FGF2,FOS,GDF15,GOT1,HMGA1,HMOX1,ITGB2,JUN,MAP4K4,NFE2L2,ODC1,PDGFC,STAT1,THBS1,TIMP1,TNFRSF10B,TP53,TYMP	Ap1,CEBPB,CREBBP,EGR1,ELK1,ERK,ESR1,FOS,IFNG,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,TP53,nitric oxide	
P2	 	TAF4	1.443	transcription regulator	 	-1.841	bias	-0.468	-0.377	5.55E-03	CARMIL1,CLDN1,GAS5,GJB2,IL1RN,KLF4,KRT6B,MAP4K4,PDGFA,PDGFC,SCUBE1,SPP1,TAF10,THBS1	 	
P2	 	arachidonic acid	 	chemical - endogenous mammalian	 	-1.191	 	0.168	-1.806	5.55E-03	CD83,EDN1,EGR1,FAS,FOS,G6PD,HMOX1,JUN,PLA2G2A,PLTP,SCD,THRSP,UCP2,VCAM1	Ap1,CREB1,EGR1,FOS,FOXO1,Insulin,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARA,PPARG,Pkc(s),RELA,RXRA,SP1,SREBF1,STAT1,arachidonic acid	
P2	 	BCL6	-1.542	transcription regulator	 	-1.753	 	-0.201	-1.072	5.55E-03	ALCAM,CCND2,CD151,CD2,CXCL10,DNAJB11,DUSP6,FAS,FCGRT,FGF2,FTH1,LITAF,MAF,PIK3CG,PLA2G2A,SOCS3,SOX6,SOX9,TP53	BCL6,CREBBP,HIF1A,IL10,IL4,IRF8,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53	
P2	 	Hdac	 	group	 	0.042	 	-0.026	0.152	5.58E-03	CSF1R,DDIT3,EDN1,EGR1,FOS,GADD45B,HIF1A,HLA-DRA,HNRNPAB,HTRA1,ITGA8,JUN,NR4A1,PREX1,RNASE1,RRM2B,SEMA3C,SFRP1,SPP1,THBS4	AHR,ARNT,CREBBP,EP300,ESR1,ESR2,HIF1A,Hdac,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53,TP63,TP73,VHL,estrogen receptor	
P2	 	IFNA2	 	cytokine	Activated	3.295	bias	0.610	 	5.60E-03	ANXA1,ATF5,CD28,CXCL10,CXCL9,DAD1,EPB41L3,FAM134A,FAS,FGF2,GBP1,GOT1,HIF1A,HLA-A,HMGCS1,IFI27L2,IRF5,ISG15,MT-ATP6,MT-CO2,PSME1,RARRES3,SOCS3,STAT1,THEMIS2,TNFRSF10B,TP53	AHR,CREBBP,ERK,IFNA2,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF	
P2	 	mir-1	-2.315	microrna	Inhibited	-3.030	bias	-0.622	 	5.64E-03	ADAM12,ANXA2,CCND2,EDN1,EML4,GATAD2A,KIF2A,PDGFA,PPP2R1B,RHEB,SEC61A1,SFRP1,SH3BGRL3,SLC25A1,SOX9,XPO6	 	
P2	 	eicosapentenoic acid	 	chemical drug	 	1.142	 	-0.100	1.477	5.65E-03	APOE,CD83,CIDEA,CSF1R,FOS,HMOX1,JUN,LEP,NFE2L2,PLIN2,TGFB2,THRSP,TP53	ATF6,Ap1,EGR1,FOS,JUN,Jnk,MYC,NFE2L2,NFKB1,NFkB (complex),P38 MAPK,PI3K (complex),PPARA,PPARG,RELA,SP1,SREBF1,STAT1,arachidonic acid,eicosapentenoic acid,oleic acid	
P2	 	estrogen receptor	 	group	Inhibited	-2.623	 	-0.050	-2.385	5.75E-03	ADIPOQ,ANXA1,CAPG,CCND2,CD68,EDN1,EGR1,FGF1,FGFR2,FLNC,FOS,HRAS,JUN,MAP1B,MAPT,MT-CO2,PCDH19,PDGFA,PDGFC,POR,SLC9A3R1,SYP,TGFB2,TGFBR1,TIMP1,TMEFF1,TP53,WNT5B	AHR,Ap1,CTNNB1,EGF,EGR1,ELK1,ERK,ESR1,ESR2,JUN,MYC,NFKBIA,NFkB (complex),RB1,RELA,SP1,STAT1,TP53,beta-estradiol,estrogen receptor,fulvestrant	
P2	 	triamcinolone acetonide	 	chemical drug	 	-1.301	 	0.021	-1.407	5.77E-03	ALDH5A1,ANOS1,ATP10A,BTG2,CAPG,CBX4,DDIT3,DUSP10,EFS,EGR1,FGFR2,FKBP5,FOS,IGFBP4,JUN,MEGF9,MYOC,PCDH19,PER1,SAA1,SCD,SLC9A3R1,SPP1,STC2,TGFB2,ZBTB16	Ap1,EGR1,FOS,JUN,Jnk,NFkB (complex),NR3C1,RELA,STAT1,TP53,triamcinolone acetonide	
P2	 	Alpha catenin	 	group	Inhibited	-3.087	bias	-0.696	 	5.83E-03	ADAMTS5,COL15A1,COL5A2,CTSB,CXCL10,ENG,IGFBP4,IL2RG,KRT6B,LYZ,PTX3,S100A8,SAA1,SOCS3,TIMP1,TNFRSF12A,VCAM1	AHR,Alpha catenin,CREBBP,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,STAT1	
P2	 	RRP1B	2.073	other	 	 	 	 	 	5.91E-03	ALDH5A1,CCND3,ITGB2,PDGFC,RPL19,RPL37,RPL37A,RPS10,RPS19,RPS5,RPS8,SERPINE2,SPP1,TOP2A,TUBG1	 	
P2	 	ATP	 	chemical - endogenous mammalian	 	0.696	bias	0.340	-0.545	5.91E-03	CD14,CD83,CLDN1,CXCL10,FLNA,FOS,GCLM,IL1RN,MBP,P2RX7,SREBF2,THBS1,TP53,TXN,VCAM1	ATP,Ap1,FOS,IL6,JUN,LEP,MYC,NFE2L2,NFKB1,NFkB (complex),P38 MAPK,PI3K (complex),PPARG,RELA,SP1,STAT1,STAT5B	
P2	 	leukotriene D4	 	chemical - endogenous mammalian	 	-1.353	bias	0.694	 	5.96E-03	ADAM12,APOLD1,CITED1,CYR61,EGR1,KLF4,LOC102724428/SIK1,NR4A1,NR4A2,PLAA	 	
P2	 	ADRB3	-11.934	g-protein coupled receptor	 	0.365	bias	0.432	-0.582	6.08E-03	EGR1,FOS,JUN,LEP,UCP2	ADIPOQ,ADRB3,Ap1,CREB1,CREBBP,CTNNB1,EGR1,EP300,FOS,FOXO1,FOXO3,INS,JUN,LEP,Mapk,NFKB1,NFkB (complex),PPARG,RELA,SP1,STAT5B,isoproterenol	
P2	 	AGPAT2	1.581	enzyme	Inhibited	-2.236	 	-0.042	-2.141	6.08E-03	ADIPOQ,LEP,PLD3,PLIN1,SCD	 	
P2	 	BTG2	-4.831	transcription regulator	 	 	 	 	 	6.08E-03	BTG2,HMOX1,NCAM1,NQO1,SOD1	BACH1,BTG2,NFE2L2,NFkB (complex),RELA	
P2	 	FZD9	1.014	g-protein coupled receptor	Activated	2.213	bias	0.721	 	6.08E-03	CXCL10,CXCL14,ISG15,SPRY4,STAT1	 	
P2	 	glutamyl-Se-methylselenocysteine	 	chemical - endogenous mammalian	 	0.447	bias	-0.466	1.490	6.08E-03	EGR1,GSTP1,JUN,PSME1,SOD1	 	
P2	 	1,10-phenanthroline	 	chemical toxicant	 	0.000	bias	0.328	-0.655	6.16E-03	HIF1A,HMOX1,PRNP,TP53	1,10-phenanthroline,APP,Ap1,CREB1,EGR1,FOS,FOXO1,HIF1A,Insulin,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,Pkc(s),RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	ACO1	-1.063	enzyme	 	 	 	 	 	6.16E-03	APP,FTH1,FTL,GAPDH	ACO1,HTT,NFE2L2,VHL,iron	
P2	 	AFP	-2.636	transporter	 	-1.980	bias	0.288	-2.551	6.16E-03	EGR1,FOS,TNFRSF10B,TNFRSF12A	 	
P2	 	Adaptor protein 2	 	complex	 	 	 	 	 	6.16E-03	CD28,HMOX1,LHCGR,RPSA	 	
P2	 	CNB-001	 	chemical reagent	Activated	2.000	bias	0.590	 	6.16E-03	ASNS,ATF4,DDIT3,SLC7A11	 	
P2	 	Fe2+	 	chemical - endogenous mammalian	 	-1.067	bias	-0.328	-0.418	6.16E-03	APP,HIF1A,HMOX1,SREBF2	AKT1,Ap1,CEBPA,CEBPB,FOXO1,Fe2+,IGF1,JUN,LDL,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1	
P2	 	L-serine	 	chemical - endogenous mammalian	 	-1.949	bias	-0.288	-1.387	6.16E-03	ATF4,PCK2,PSAT1,TP53	 	
P2	 	PARP2	1.202	enzyme	 	-1.980	bias	0.328	-2.629	6.16E-03	ADIPOQ,FAS,LEP,TNFRSF10B	PARP2,SP1,olaparib	
P2	 	enoxacin	 	chemical drug	 	-1.000	bias	-0.590	 	6.16E-03	ATP6V1B2,ATP6V1E1,FOS,LCP1	 	
P2	 	enterolactone	 	chemical - endogenous non-mammalian	 	1.000	bias	0.590	 	6.16E-03	ESR2,IL1RN,MKI67,SPP1	 	
P2	 	mir-7	-2.350	microrna	 	-0.758	bias	-0.721	 	6.16E-03	ABCC1,KLF4,MKNK2,PIK3R3	 	
P2	 	26s Proteasome	 	complex	Inhibited	-3.339	bias	-0.371	-1.887	6.17E-03	ATF5,CLCN7,CTSA,CTSB,CTSD,DDIT3,GAS5,LAMP1,PRNP,PTPA,SOCS3,SQSTM1,STAT1,TP53,UBE2I,VPS11	26s Proteasome,AHR,CHUK,CTNNB1,EIF2AK3,ESR1,ESR2,FOXO1,FOXO3,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PRNP,RELA,SP1,STAT1,TP53,estrogen receptor	
P2	 	MAP2K1/2	 	group	 	0.810	bias	0.493	-0.791	6.24E-03	CCND2,DDIT3,DUSP4,EGR1,FOS,HMOX1,HSPA5,HSPB1,JUN,PDGFA,PIK3CG	Ap1,CREBBP,EGR1,ERK1/2,FOS,JUN,Jnk,MAP2K1/2,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	NFYC	1.195	transcription regulator	 	 	 	 	 	6.36E-03	COL5A3,FGFR2,FTH1,HLA-DRA,MTPN,SDF2,THRSP,TXNDC12	 	
P2	 	SPHK1	-1.243	kinase	 	-0.539	 	0.175	-1.028	6.36E-03	APP,DDIT3,EGR1,ERN1,JUN,SOCS3,TIMP1,TP53	Ap1,CREB1,EGR1,FOS,HTT,JUN,Jnk,L-glutamic acid,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,SPHK1,STAT1,nitric oxide	
P2	 	ethionine	 	chemical toxicant	Activated	2.828	bias	0.536	 	6.36E-03	ANXA1,CD14,PSMB10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TNFRSF12A	 	
P2	 	S100A9	1.507	other	 	1.493	 	0.209	0.576	6.42E-03	ADAMTS5,ALPL,C1QB,CPM,CXCL10,CXCL14,EPB41L4B,ETV5,FAS,FCGR2A,GJB2,ISG15,KCNMA1,MCF2L,NTRK3,PDGFC,PER1,RNASE6,S100A8,SCUBE1,VCAM1	IL6,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,S100A8,S100A9,STAT1	
P2	 	DRAP1	2.220	transcription regulator	 	 	 	 	 	6.44E-03	GAPDH,HIST1H1B,HLA-DRA,RPL7A,RPLP0,SOD1	 	
P2	 	JAK inhibitor I	 	chemical - kinase inhibitor	 	-1.633	bias	-0.480	-0.456	6.44E-03	CCND2,CXCL10,CXCL9,LHCGR,TIMP1,TRPA1	CREBBP,FOS,IRF8,JAK inhibitor I,JAK2,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1	
P2	 	arotinoid acid	 	chemical toxicant	 	1.709	bias	0.407	0.730	6.44E-03	FOLR2,FOS,ODC1,PLTP,SCD,SOX9	Ap1,CTNNB1,EGF,EGFR,EGR1,FOXO1,HTT,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TNF,arotinoid acid	
P2	 	deoxycorticosterone acetate	 	chemical drug	 	1.612	bias	0.360	0.750	6.44E-03	CD68,CYP4A11,EDN1,SLC9A1,SPP1,VCAM1	 	
P2	 	isobutylmethylxanthine	 	chemical toxicant	 	1.076	bias	0.363	-0.405	6.48E-03	ACSL3,ADIPOQ,CD14,EGR1,FAM89B,FOS,GAPDH,IL2RG,INSR,ITGB2,JUN,PLIN1,PLIN2,RAB5C,RAB7A,SCD,SYP,TIMP1,TUBB	Ap1,CEBPA,CEBPB,FOS,FOXO1,FOXO3,INS,Ins1,JUN,MYC,NFkB (complex),PPARA,PPARG,RXRA,SMARCA4,SP1,SPI1,STAT5B,TP53,estrogen receptor,isobutylmethylxanthine	
P2	 	6-cyano-7-nitroquinoxaline-2,3-dione	 	chemical reagent	 	 	 	 	 	6.57E-03	EGR1,FOS,JUN	6-cyano-7-nitroquinoxaline-2,3-dione,CREB1,FOS,NFkB (complex),PRL,RELA,SP1,STAT1,STAT5B,dopamine,estrogen receptor	
P2	 	AATF	 	transcription regulator	 	 	 	 	 	6.57E-03	APP,FAM89B,JUN	 	
P2	 	CNGB3	-3.648	ion channel	 	 	 	 	 	6.57E-03	CAPN2,DDIT3,HSPA5	 	
P2	 	SERCA	 	group	 	 	 	 	 	6.57E-03	BTG2,EGR1,JUN	AHR,ERK,JUN,NFKB1,NFkB (complex),P38 MAPK,RELA,SERCA,SP1,STAT1	
P2	 	SLC6A2	-1.651	transporter	 	 	 	 	 	6.57E-03	ADCY1,DYNLL1,PSAP	CREB1,CREBBP,ELK1,FOS,FOXO1,SLC6A2,cocaine	
P2	 	SRPK1	1.446	kinase	 	 	 	 	 	6.57E-03	CXCL10,INSR,RAC1	 	
P2	 	YES1	-1.121	kinase	 	 	 	 	 	6.57E-03	HMOX1,NFE2L2,NQO1	AKT1,Ap1,BACH1,EGR1,FOS,FOXO1,Jnk,NFE2L2,NFkB (complex),RELA,SP1,STAT1,YES1	
P2	 	fluphenazine	 	chemical drug	 	 	 	 	 	6.57E-03	FOS,NR4A1,NR4A2	 	
P2	 	TAL1	-2.207	transcription regulator	 	0.832	 	-0.018	0.898	6.65E-03	ARSA,BCOR,BHMT2,CMA1,FCER1A,HLA-A,IL10RA,JUN,KIT,MS4A2,MVD,PLA2G2A,RASD1,RNASE6,RPS3A,TCF7,TMEFF1,TPSAB1/TPSB2,TUBB4B,UBXN1,URB1-AS1,YARS,ZNF827	TAL1,TCF3	
P2	 	raloxifene	 	chemical drug	 	0.342	 	0.000	0.342	6.78E-03	ALDH4A1,CNBP,DUSP4,DYNLL1,ENG,ESR2,HMOX1,IFI30,IGFBP4,JUN,LITAF,MIF,MKI67,RAC1,SIAH2,SMPD1,SNCG,SOD1,SPP1,TGFB2,TIMP1,TOP2A	AHR,CEBPA,CEBPB,ELK1,ESR1,ESR2,FOS,FOXO1,IGF1,IL6,JUN,MAPK3,MYC,NFKB1,NFkB (complex),PRL,RELA,SP1,STAT1,STAT5B,TP53,estrogen receptor,raloxifene	
P2	 	ONECUT1	1.467	transcription regulator	 	 	 	 	 	6.80E-03	AASS,ACSS3,ALDH5A1,ATG9A,CLCN4,COL5A3,COPS7A,COX7A2L,CYGB,EMG1,FADS3,FAS,G3BP2,GSS,GUF1,HIST1H4H,HLA-G,HSPH1,ITGAV,PFKFB1,PFKL,PHB2,RPLP1,SLC1A3,SNRPD2,STMN2,TCF7,TMBIM6,TRUB2,TXNDC12,USP46,VCP	 	
P2	 	AG490	 	chemical - kinase inhibitor	 	0.064	bias	-0.559	 	6.96E-03	AKR1C3,CCND3,CD68,EDN1,ESR2,FGF2,FOS,PLA2G2A,SAA1,SOCS3,SPP1,STAT1,TIMP1	AG490,AHR,Ap1,CREBBP,ERK,ERK1/2,FOS,IL6,IRF8,JUN,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1	
P2	 	lipoteichoic acid	 	chemical - endogenous non-mammalian	 	1.899	bias	0.596	 	7.03E-03	CCR1,CD14,CD83,CXCL10,CYBB,HIF1A,HMOX1,IL1RN,NR4A1,NR4A2,TOLLIP	AHR,CEBPA,CREBBP,IL1B,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TNF,lipoteichoic acid	
P2	 	PP2/AG1879 tyrosine kinase inhibitor	 	chemical - kinase inhibitor	 	-0.812	bias	-0.440	0.679	7.07E-03	CXCL16,EDN1,FGF2,FOS,GFPT1,HIF1A,HMOX1,PER1,PTPRJ,RAC1,SPP1,TP53	AKT1,Ap1,CREBBP,ERK1/2,FOS,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PP2/AG1879 tyrosine kinase inhibitor,Pkc(s),RELA,SP1,STAT1	
P2	 	SFTPA1	-10.223	transporter	 	0.577	 	-0.247	1.432	7.07E-03	AKR1C1/AKR1C2,AMOT,CYR61,EGR1,ERN1,EVI2B,FOS,FOSB,MAP1B,PLIN2,RASD1,TCEA3	CEBPA,JUN,LDL,NFKB1,NFKBIA,NFkB (complex),RELA,SFTPA1,SP1,STAT1,TNF,lipopolysaccharide	
P2	 	cyclophosphamide	 	chemical drug	 	0.319	bias	0.393	-1.012	7.07E-03	CAPN6,FAS,FCGR2A,FOS,GAS5,ODC1,S100A11,SOX9,SPP1,THBS1,TIMP1,TNFRSF12A	Ap1,IL6,JUN,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),RELA,SP1,STAT1,TNF,cyclophosphamide	
P2	 	TGFB3	1.460	growth factor	 	0.983	bias	0.544	 	7.10E-03	ADAM12,CYR61,EEF1D,ENG,FGF2,FOS,FOSB,HTRA1,ITGAV,JUN,SCD,SDC3,SERPINE2,THBS1,TNS1	CREBBP,EGR1,ERK1/2,ESR1,ESR2,FGF2,FOS,HRAS,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TGFB3,TP53,beta-estradiol	
P2	 	ERK1/2	 	group	 	0.693	bias	0.444	-1.545	7.17E-03	ADIPOQ,AKR1C3,CCND2,CTSB,CXCL10,CYBB,DUSP4,EDN1,EGR1,ENO1,ESR2,FGF2,FGFR2,FKBP5,FOS,FOSB,HIF1A,HLA-A,HMGA1,HSPA5,JUN,PSMB10,PSMB6,RAC1,SOCS3,SOX9,SPP1,SPRY4,TIMP1,TNFRSF10B,TYMP,VCAM1	CEBPA,CEBPB,EGR1,ERK1/2,FOXO1,IGF1,IL1B,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TGFB1,TNF,TP53	
P2	 	MAP2K1	1.500	kinase	 	1.011	bias	0.594	 	7.26E-03	ABCC1,APOE,CSTA,CTSB,DAB2,DUSP6,ENO1,ETV5,FGF2,FLNA,FOS,HIF1A,HSPA5,JUN,LEP,LHCGR,MBP,RRAGD,SERPINE2,SIRPA,THBS1,UNC5B	Ap1,CEBPA,CREBBP,EGR1,ELK1,ERK1/2,ESR1,FOS,FOXO1,JUN,MAP2K1,MYC,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PD98059,RELA,SP1,STAT1,TGFB1,TP53	
P2	 	SHC1	1.651	other	Activated	2.560	 	0.124	2.242	7.29E-03	FOS,FTH1,FTL,GSTP1,NQO1,SQSTM1,TXN	Ap1,EGR1,FOS,JUN,Jnk,MYC,NFE2L2,NFkB (complex),PI3K (complex),RELA,SHC1,SRC	
P2	 	rosuvastatin	 	chemical drug	 	0.956	 	0.135	0.601	7.29E-03	CYBB,HMGCS1,HMOX1,KIT,MVD,PMVK,RAC1	 	
P2	 	staurosporine	 	chemical - kinase inhibitor	 	-0.428	 	-0.094	-0.096	7.34E-03	ANXA5,BTG2,CD28,CD53,CREG1,FAS,FCGR2A,FOS,HMOX1,ISG15,ITGB2,KRT14,NQO1,NR4A1,ODC1,TP53	AHR,Ap1,CEBPB,EGR1,ERK,FOS,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,nitric oxide,staurosporine	
P2	 	Mek	 	group	 	0.747	bias	0.331	-0.730	7.39E-03	APOE,CCND2,CCND3,CSF1R,CXCL10,CXCL9,DUSP6,EGR1,ETV5,FOS,GNL3,HSPB1,JUN,LEP,NR4A1,SNCG,SPRY4,THBS1,TOP2A,TP53,UNG	AKT1,CEBPB,CREBBP,ESR1,FOXO1,IRF8,JUN,MAP2K1,MYC,Mek,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	RUVBL1	1.462	transcription regulator	 	1.890	bias	0.721	 	7.46E-03	CARS,CCND2,GADD45B,HIST1H2BK,HIST2H2AC,METTL23,SESN2,SRD5A1	 	
P2	 	IKBKG	 	kinase	Activated	2.773	bias	0.550	 	7.48E-03	CCR1,CTSB,DUSP6,FOS,GM2A,GRN,HLA-A,IL1RN,ISG15,NAGLU,PLD3,PTX3,SEMA3C,SERPINE2,SFRP1,SOCS3,TMEM176B	AHR,CHUK,CREBBP,CTNNB1,IKBKB,IKBKG,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF,TP53	
P2	 	2-amino-5-phosphonovaleric acid	 	chemical - other	Activated	2.215	 	0.097	1.797	7.54E-03	ANLN,ATF4,BTG3,DCLK2,DUSP6,EGR1,FOS,FOSB,GADD45B,JUN,KCTD2,LHFPL2,MLST8,NPY1R,NR4A1,NR4A2,NRN1,RPS15A,SPRY4	2-amino-5-phosphonovaleric acid,Ap1,CREB1,CTNNB1,FOS,FSH,JUN,NFkB (complex),RELA,dopamine,estrogen receptor,nitric oxide	
P2	 	MKL1	1.228	transcription regulator	 	-1.369	 	-0.144	-0.835	7.54E-03	ARPC1B,ARPC4,CD151,CMA1,COMT,CPA3,CTSG,DSG1,EGR1,EYA2,FLNA,FOS,G0S2,HLA-A,MYL9,OSCP1,RAC1,S100A8	 	
P2	 	PPARD	1.226	ligand-dependent nuclear receptor	 	0.265	bias	0.348	-1.341	7.58E-03	ADORA1,ALDH2,ALDH3A2,APOB,APOE,C1QA,C1QB,C1QC,CCND2,CD68,LDHB,MPEG1,PCSK6,PLA2G2A,PLIN2,RABL6,SCD,SERINC2,STAT1,TCEA3,THBS1,TNFRSF12A,UCP2	ATF6,EGR1,JUN,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,RELA,RXRA,SREBF1,arachidonic acid,fatty acid,linoleic acid,oleic acid	
P2	 	NUPR1	3.891	transcription regulator	 	1.297	 	-0.212	2.813	7.74E-03	ALDH5A1,ARHGEF26,B3GNT5,CARMIL1,CD63,CD68,CYR61,CYSTM1,DDIT3,FAM162A,FGF1,FUCA1,GAB2,GDF15,HIST1H1B,HIST1H3J,HLTF,HOXB5,HSPA2,KLF4,LHFPL2,LOC102724428/SIK1,MAFG,MAT2A,MEGF9,MKI67,NR1D1,NRBF2,NRROS,NRSN2,NUPR1,P4HA2,PEA15,PFKFB3,PIK3R1,PPFIBP2,PRNP,PTPRJ,PXDC1,RAB32,SESN2,SIGMAR1,TESK1,TMEM268,TOLLIP,TP53,TRIB3,TRIM16,TSC22D2,UNC5B,VANGL1,ZNF483	 	
P2	 	dopamine	 	chemical - endogenous mammalian	 	1.063	 	0.087	0.770	7.77E-03	CLCN3,DDIT3,EGR1,FOS,GIPR,HMOX1,JUN,NPR3,PPP1CA,PPP1R1B,PPP1R2,SDHB,SLC1A3,SYP,TMEM205	Ap1,CEBPB,CREB1,CREBBP,EGR1,FOS,JUN,Jnk,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,Pde,Pka,Pkc(s),RELA,STAT1,cyclic AMP,dopamine	
P2	 	nifedipine	 	chemical drug	 	0.181	 	-0.193	0.839	7.87E-03	ABCC3,ADIPOQ,AGER,ATP2B1,CYP3A5,CYP4A11,DUSP4,EDN1,FOS,INSR,NR4A1,VCAM1	ARNT,CEBPA,CREB1,CREBBP,CTNNB1,D-glucose,ERK1/2,FOS,FOXO1,HIF1A,HTT,Insulin,MYC,NFKBIA,NFkB (complex),NR3C1,PPARA,PPARG,RELA,RXRA,SP1,glucocorticoid,nifedipine	
P2	 	linoleic acid	 	chemical - endogenous mammalian	 	1.508	 	0.240	0.711	7.89E-03	APOB,APP,DDIT3,EDN1,HSPA5,PLIN2,PLIN5,S100A8,SCD,UCP2,VCAM1	Ap1,CEBPA,FOXO1,JUN,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARD,PPARG,Pkc(s),RELA,RXRA,SREBF1,fatty acid,linoleic acid	
P2	 	AGN194204	 	chemical drug	Activated	3.494	bias	0.637	 	7.91E-03	ANXA2,BZW2,CAMK2D,GAPDH,H2AFZ,HIST1H1C,ITGB2,LAMP1,MKI67,NPC2,NSMAF,PLIN2,PRNP,RAMP3,SCD,SEMA4B,SLC3A2,SPP1,STIM1,TIMP1,TOP2A	 	
P2	 	MPZ	2.682	other	 	 	 	 	 	7.92E-03	ATF4,DDIT3,HMGCS1,HSPA5,MVD	 	
P2	 	Pdgf Ab	 	complex	 	0.506	bias	0.551	 	7.92E-03	COL8A1,FOS,HIF1A,HMOX1,SCD	ARNT,Ap1,EGR1,EP300,FOS,HIF1A,JUN,MYC,Mapk,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PI3K (complex),PPARG,Pdgf Ab,RELA,STAT1,TP53,VEGFA,VHL	
P2	 	SLC6A3	-11.272	transporter	 	1.067	 	0.144	0.782	7.92E-03	ADCY1,DYNLL1,FOSB,PPP1R1B,PSAP	CREB1,CREBBP,ELK1,FOS,FOXO1,SLC6A3,cocaine	
P2	 	dichlororibofuranosylbenzimidazole	 	chemical toxicant	 	0.068	bias	-0.450	0.955	7.92E-03	CTSD,CYP3A5,ESR2,HIF1A,TP53	EP300,EPAS1,HIF1A,IL6,JUN,NFKB1,NFkB (complex),RELA,STAT1,VHL,dichlororibofuranosylbenzimidazole	
P2	 	SUPT16H	1.169	transcription regulator	 	 	 	 	 	7.96E-03	EGR1,HIST1H1C,HIST1H2AC,HNRNPK,LYPLA1,PDGFA	 	
P2	 	oltipraz	 	chemical drug	Activated	2.369	bias	0.663	 	7.96E-03	ABCC3,FTH1,GSTP1,NQO1,SLCO2B1,TP53	 	
P2	 	rimonabant	 	chemical drug	Inhibited	-2.401	bias	-0.317	-1.639	7.96E-03	ADIPOQ,FGF2,FOS,HSPA5,IL1RN,TP53	CEBPB,CREB1,CREBBP,ERK1/2,FOS,HTT,JUN,L-glutamic acid,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,STAT5B,cyclic AMP,rimonabant	
P2	 	sorafenib	 	chemical drug	 	-0.927	 	-0.240	-0.370	7.96E-03	CCND2,CCND3,DDIT3,ERN1,HIF1A,HSPA5	CEBPB,CREBBP,ERK1/2,FOS,JUN,KIT,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,bortezomib,sorafenib	
P2	 	corticosterone	 	chemical - endogenous mammalian	 	0.093	 	0.029	-0.008	7.98E-03	ANXA1,APOB,APP,ATP2B1,DDIT3,EDN1,FGF2,FKBP5,FOS,GLUL,HSPA5,JUN,LEP,SFRP1,SLC1A2,UCP2	Ap1,CREB1,CREBBP,ERK1/2,FOS,HTT,JUN,L-glutamic acid,LEP,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,Pkc(s),RELA,SP1,STAT1,STAT5B,corticosterone	
P2	 	FOLR1	2.669	transporter	 	 	 	 	 	8.16E-03	ARHGDIB,ATP6V1B2,CLPTM1,DUSP6,GAS5,GBA,LYZ,MRPS6,PFN1,RPS24,SLC3A2,SNRPF,ST3GAL6,SYNGR2	 	
P2	 	TCF3	1.602	transcription regulator	 	-1.043	 	0.090	-1.352	8.27E-03	ADIPOQ,ANLN,AP3D1,ARSA,CCND2,CCND3,CD4,EPRS,FGFR2,GADD45B,GM2A,JUN,KIT,KLF4,LHCGR,LMO4,MKI67,MSMO1,PSAP,RPS3A,SLC12A2,SLC7A5,SOCS3,TMEFF1,TOP2A,URB1-AS1	 	
P2	 	ADM	-1.983	other	 	-0.159	 	-0.088	0.012	8.29E-03	EDN1,FGF2,FOS,HIF1A,HRAS,RAMP2,RAMP3,SPP1,VCAM1	ADM,AKT1,CREBBP,EDN1,ELK1,ERK1/2,FOS,FOXO1,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,SRC,STAT1	
P2	 	DETA-NONOate	 	chemical reagent	 	-0.076	 	0.162	-0.550	8.29E-03	FAS,FOS,GLO1,HIF1A,HMOX1,S100A8,TIMP1,TP53,VCAM1	Ap1,CEBPB,DETA-NONOate,FOS,IL6,JUN,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,RELA,SP1,STAT1,TP53	
P2	 	ELK1	1.612	transcription regulator	 	-0.404	bias	0.604	 	8.29E-03	EGR1,FOS,ITGAV,JUN,NUPR1,SLC7A11,SPP1,THBS1,TNFRSF10B	AHR,Ap1,CREBBP,ELK1,ERK,ESR1,FOS,HIF1A,Hdac,JUN,MAPK3,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TCF,TNF,TP53	
P2	 	mono-(2-ethylhexyl)phthalate	 	chemical toxicant	 	1.569	bias	0.631	 	8.47E-03	ADIPOQ,ATP5D,CCND2,CYP4A11,DGAT2,ENO1,FAS,FOS,G6PD,GAPDH,GFPT1,KIF5B,MDH2,NDUFA2,PLIN2,PPTC7,SDHB,SDHC,SOD1,TALDO1,TSPO	Ap1,CEBPA,EGR1,ELK1,ESR1,FOXO1,JUN,NFkB (complex),NRF1,PPARA,PPARD,PPARG,PPARGC1A,RELA,RXRA,SP1,SREBF1,TP53,mono-(2-ethylhexyl)phthalate	
P2	 	imatinib	 	chemical drug	 	-1.868	 	-0.141	-1.383	8.50E-03	APP,CCND2,CYBB,DAB2,HMOX1,IGKC,IGLC1,KIT,PLIN2,PRNP,SMPD1,STAT1,TNFRSF10B	Ap1,FOS,IL6,JUN,KIT,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1,TNF,imatinib	
P2	 	SP3	1.392	transcription regulator	 	-0.163	bias	0.343	-1.280	8.58E-03	ASNS,CES1,DMD,EGR1,FAS,FOS,GDF15,HSPA5,JUN,KLF4,LHCGR,MAT2A,NPTXR,NR5A2,PKM,PREX1,PRKRA,SLC19A1,STAT1,TGFBR1,TIMP1,TP53,TSPO,TXNRD1,XYLT1	Ap1,JUN,NFkB (complex),RNA polymerase II,SP3,TP53	
P2	 	BMS-690514	 	chemical drug	 	-1.890	bias	-0.328	-1.023	8.68E-03	CCND3,CYCS,DDIT3,HSPA4,HSPA8,HSPH1,TP53RK	 	
P2	 	HLX	1.117	transcription regulator	 	-0.342	bias	-0.315	0.485	8.68E-03	CLDN1,CTSS,EGR1,GDF15,JUN,PLXNA1,UNC5B	 	
P2	 	MAPK7	1.726	kinase	 	-0.529	bias	0.384	-1.524	8.68E-03	EDN1,HMOX1,JUN,KLF4,NQO1,NR4A1,TP53	AHR,Ap1,CEBPA,CREBBP,EP300,FOS,FOXO1,JUN,MAPK7,MYC,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PML,PPARA,PPARG,RELA,RXRA,SP1,STAT1	
P2	 	RAB1B	-1.670	other	 	1.238	bias	0.415	0.164	8.68E-03	DERL1,JUN,NAPA,RAB11FIP2,RAB32,RRAGC,STXBP1	 	
P2	 	S-adenosylmethionine	 	chemical - endogenous mammalian	 	-0.488	bias	-0.459	0.702	8.68E-03	FOS,GCLM,HMOX1,MAF,MAFG,MAT2A,RAC1	ADIPOQ,Ap1,CTNNB1,EGR1,ELK1,ESR1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,S-adenosylmethionine,SP1,TNF,TP53	
P2	 	SSRP1	1.098	other	 	 	 	 	 	8.68E-03	EGR1,HIST1H1C,HIST1H2AC,HNRNPK,LYPLA1,MT-TY,PDGFA	 	
P2	 	parthenolide	 	chemical drug	 	1.732	bias	-0.323	2.515	8.68E-03	ADAMTS5,DDIT3,HMOX1,NFE2L2,TNFRSF10B,TP53,VCAM1	AHR,CEBPB,CREBBP,DDIT3,FOXO1,HIF1A,JUN,MYC,NFKB1,NFKBIA,NFkB (complex),PPARA,RELA,STAT1,TP53,palmitic acid,parthenolide,reactive oxygen species	
P2	 	sildenafil	 	chemical drug	 	-1.195	 	-0.116	-0.890	8.68E-03	AIF1,APP,CYBB,FGF1,HMOX1,SLC9A1,SYP	Ap1,FOS,JUN,NFkB (complex),RELA,nitric oxide,sildenafil	
P2	 	KDR	-1.009	kinase	 	 	 	 	 	8.68E-03	ANXA2,EPHB3,HMOX1,NME1,NME2,NR4A1,SFRP1,SOX18	CTNNB1,EGR1,FOXO1,FOXO3,KDR,MYC,NFKB1,NFkB (complex),RELA,STAT1,VEGFA,Vegf	
P2	 	T3-TR-RXR	 	complex	Activated	2.157	bias	0.580	 	8.68E-03	AKR1C1/AKR1C2,AKR1C3,ENO1,ME1,SREBF2,SYT2,THRSP,UCP2	 	
P2	 	emodin	 	chemical drug	Inhibited	-2.219	bias	-0.360	-1.419	8.68E-03	ABCC1,ADIPOQ,CCR1,HSPA5,LEP,MKI67,SOD1,VCAM1	Ap1,CEBPA,CEBPB,CREBBP,EGR1,ESR1,FOS,JUN,MAP2K1,MYC,Mapk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PPARG,RELA,SP1,STAT1,TP53,emodin,troglitazone	
P2	 	CHRM1	-1.622	g-protein coupled receptor	 	-1.981	bias	0.360	-2.694	8.72E-03	CYR61,EGR1,FOS,JUN	Ap1,CEBPB,CHRM1,CREBBP,ELK1,ERK1/2,FOS,JUN,MAPK3,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,Pkc(s),RELA,STAT1,TP53,cyclic AMP	
P2	 	PIK3R2	2.745	kinase	 	 	 	 	 	8.72E-03	CXCL10,ISG15,MKI67,PIK3R1	AKT1,FOXO1,MYC,NFKB1,NFKBIA,NFkB (complex),PIK3R2,RELA,SP1,STAT1,TP53	
P2	 	VGLL3	-1.088	other	 	0.000	bias	0.721	 	8.72E-03	GADD45B,SOX9,SPP1,THBS1	 	
P2	 	Gsk3	 	group	Activated	2.392	bias	0.301	1.506	8.83E-03	ATF4,DDIT3,FOS,GDF15,HIF1A,JUN,SPP1,SREBF2,STAT1,TNFRSF10B,TP53	AHR,Ap1,CEBPB,CREBBP,EGR1,FOS,Gsk3,IFNG,IRF8,JUN,Jnk,MYC,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,STAT1,TP53,TP63,TP73	
P2	 	MAPK3	1.538	kinase	 	-0.095	bias	0.547	 	8.83E-03	CSTA,DUSP4,EGR1,FOS,FOSB,JUN,SOD1,SPP1,THBS1,TIMP1,TNFRSF10B	AHR,Ap1,CREBBP,ELK1,ERK,ERK1/2,FOS,Hdac,JUN,MAPK3,Mapk,NFKB1,NFKBIA,NFkB (complex),PPARG,RELA,SP1,STAT1	
P2	 	PTPN11	1.235	phosphatase	 	-0.559	 	0.111	-0.865	8.83E-03	ABCA3,CD14,CD68,CSF1R,CYBB,EGR1,FOS,JUN,KIT,SOCS3,TP53	15-deoxy-delta-12,14 -PGJ 2,Ap1,GATA1,IL6,IRF8,JUN,LEP,NFE2L2,NFKB1,NFkB (complex),PPARG,PTPN11,RELA,RNA polymerase II,SPI1,STAT1,STAT5B,TP53	
P2	 	HIST1H1T	-1.733	other	 	0.832	bias	0.436	-0.739	9.36E-03	ARPC5,FKBP4,FOS,GLUL,HSPA4,MARS,OGT,PCCB,PHB2,RILPL1,SGF29,TMEM230,TMEM53	 	
P2	 	Hist1h1a	 	other	 	0.832	bias	0.436	-0.739	9.36E-03	ARPC5,FKBP4,FOS,GLUL,HSPA4,MARS,OGT,PCCB,PHB2,RILPL1,SGF29,TMEM230,TMEM53	 	
P2	 	NR1I2	-1.971	ligand-dependent nuclear receptor	Activated	2.169	 	0.191	1.374	9.38E-03	ABCC3,ALAS1,ALDH3A2,CES1,CES2,CYP3A5,CYP4A11,ENTPD5,GADD45B,GLUL,GOT1,GSTP1,HMGCS1,JUN,MT-CO2,PGD,POR,S100A8,SCD	CEBPA,FOS,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),NR1I2,PPARG,RELA,SP1,SREBF1,TNF,TP53,cholesterol,dexamethasone,mifepristone,nifedipine	
P2	 	TET2	1.255	other	Activated	3.500	bias	0.440	1.738	9.41E-03	AFF3,ANXA2,CBR1,CHST11,FAM129A,HS6ST1,ITGB2,MTSS1,PXDC1,RNF144A,S100A8,SH2B3,TIMP1,TRIOBP,XYLT1,ZBTB16	 	
P2	 	carboplatin	 	chemical drug	 	0.707	bias	0.420	-0.482	9.48E-03	ASNS,CAPN6,FCGR2A,PNKD,SPP1,TIMP1,TNFRSF12A,TP53,TUBB	 	
P2	 	fluocinolone acetonide	 	chemical drug	 	0.333	 	-0.107	0.655	9.48E-03	ANOS1,FKBP5,LIMCH1,MYOC,PCDH19,PIR,SAA1,SOCS3,ZBTB16	 	
P2	 	FGFR2	1.927	kinase	 	1.893	 	0.211	1.144	9.48E-03	AMOT,BMPER,CCND2,CITED1,CUBN,DAB2,FAS,FGFR2,GLIPR1,HRAS,LGALS2,MBP,NR5A2,PLXNB2,SFRP1,SPP1,VCAM1	CREBBP,ERK1/2,FGFR2,FOS,NFKB1,NFKBIA,NFkB (complex),RELA,SP1,TNF	
P2	 	CDK5	2.776	kinase	 	0.555	bias	0.317	-0.149	9.73E-03	CD14,GLB1,JUN,KCNMA1,MBP,PPP1R1B	Ap1,CDK5,CEBPB,ESR1,FOS,JUN,MAP2K1,MYC,NFkB (complex),SP1,STAT1	
P2	 	cyanocobalamin	 	chemical - endogenous mammalian	 	-0.600	 	0.157	-0.945	9.73E-03	APP,CSNK1A1,JUN,PER1,PRNP,SFRP1	 	
P2	 	CXCL12	1.455	cytokine	 	-0.447	bias	0.432	-2.489	9.75E-03	AIF1,AKR1C3,ARPC4,CXCL10,CYP3A5,DAD1,EGR1,FAS,FLNA,FOS,JUN,KIT,LCP2,MAPK8IP2,MAPRE3,NR2F6,NR4A1,SOCS3,SSBP1,TIMP1,TNFRSF10B,TP53,ZBTB16	AHR,Ap1,CXCL12,EGR1,ERK,FOS,IRF8,JUN,Jnk,NFKB1,NFKBIA,NFkB (complex),P38 MAPK,PTPN11,RELA,SP1,SPI1,STAT1	
P2	 	ATF6	1.383	transcription regulator	 	1.601	bias	0.533	 	9.83E-03	APP,DDIT3,DNAJB11,FOS,HSPA5,PLIN2,PRNP,RAN,RHEB,TNFRSF10B	APP,ATF6,CREB1,DDIT3,FOS,FOXO1,HIF1A,Insulin,JUN,NFE2L2,NFKB1,NFKBIA,NFkB (complex),PPARA,PPARG,RELA,SREBF1,STAT1,cholesterol	
P2	 	chloropromazine	 	chemical drug	 	-1.118	bias	0.277	-1.721	1.01E-02	CD83,FOS,HMGCS1,MSMO1,NR4A1,NR4A2,SCD,SREBF2	 	
P2	 	hyaluronic acid	 	chemical - endogenous mammalian	 	-0.059	bias	0.279	-1.075	1.01E-02	CD83,CSF1R,CXCL10,FOS,IRF5,JUN,NR4A1,NR4A2,PTPRC,SOCS3,SOX9,SPP1,TGFB2,TIMP1,VCAM1	 	
P2	 	NADPH oxidase	 	complex	 	0.447	bias	0.466	-0.596	1.01E-02	CYBB,FOS,HMOX1,JUN,VCAM1	 	
P2	 	PARP9	1.168	enzyme	Activated	2.219	bias	0.645	 	1.01E-02	CD74,HLA-DQA1,HLA-DQB1,ISG15,STAT1	 	
P2	 	RHOJ	-1.083	enzyme	 	 	 	 	 	1.01E-02	ACTG1,ADIPOQ,ANXA1,CCNI,CNBP	 	
P2	 	ammonium chloride	 	chemical drug	 	1.342	bias	0.341	0.578	1.01E-02	APP,CD151,CTSB,EDN1,SQSTM1	 	
P2	 	ezetimibe	 	chemical drug	Activated	2.216	bias	0.450	1.218	1.01E-02	APOB,HMGCS1,MVD,PMVK,SREBF2	 	
P2	 	leuprolide	 	biologic drug	Inhibited	-2.216	 	0.080	-2.393	1.01E-02	APP,EGR1,NR4A1,PEA15,TIMP1	 	
P2	 	Histone h4	 	group	 	 	 	 	 	1.02E-02	ADIPOQ,BTG3,CCND3,CXCL10,FOS,G6PD,GSTP1,KIF5C,NLGN1,POLD2,PREX1,PRMT3,RPL12,SFRP1,SOCS3,SPP1,TGFBR1,VCAM1	 	
P2	 	THRA	1.361	ligand-dependent nuclear receptor	 	0.440	 	0.010	0.417	1.02E-02	APP,ATF4,CSNK1A1,CTBP1,CXCL10,ENG,FOS,HMOX1,JUN,MBP,NME1,POR,SLC9A1,SREBF2,THRSP,TP53	 	
P2	 	acetovanillone	 	chemical drug	 	-1.947	bias	-0.509	 	1.03E-02	APP,CXCL10,EDN1,HMOX1,MSR1,OSGIN1,UCP2	 	
P2	 	green tea polyphenol	 	chemical drug	 	0.174	 	-0.180	0.645	1.03E-02	ADIPOQ,ANXA1,FOS,HMOX1,JUN,PIK3R1,TP53	 	
P2	 	mercuric chloride	 	chemical toxicant	 	 	 	 	 	1.03E-02	DDIT3,HMOX1,HSPA9,HSPB1,JUN,SPP1,TXN	 	
P2	 	monocrotaline	 	chemical toxicant	 	0.577	 	0.109	0.313	1.03E-02	CYBB,FHL1,HMOX1,NCAM1,PDGFA,SLC9A1,SPP1	 	
P2	 	EIF2AK2	-1.017	kinase	 	1.783	bias	0.627	 	1.03E-02	ATF4,DDIT3,EGR1,ERAP2,FAS,FOS,ISG15,KCTD13,NNMT,PSMB10,SOCS3,STAT1,TP53	 	
P2	 	olanzapine	 	chemical drug	 	0.043	 	0.215	-0.723	1.07E-02	AOX1,FGFR2,FOS,HLA-G,HMGCS1,HMOX1,HSPA8,NR4A1,NR4A2,S100A8,SLC24A3,SLC38A1,SNCG,SOD1	 	
P2	 	plicamycin	 	chemical drug	 	-1.260	bias	-0.276	-0.239	1.07E-02	GJB2,HIF1A,HMOX1,IGFBP4,MIF,NAPA,NFE2L2,PPP1R1B,SERPINE2,SLC40A1,SOCS3,TIMP1,TP53,TYMP	 	
P2	 	STAT3	-1.361	transcription regulator	 	-0.822	bias	0.299	-2.564	1.07E-02	ADIPOQ,CCND2,CCR1,CD209,CD74,CD83,CTSB,CXCL10,CXCL9,DDIT3,DVL3,EGR1,ESR2,FAS,FCER1G,FGF2,FOS,GLIPR1,HIF1A,HLA-A,HLA-DQA1,HMOX1,HOXA10,IFI30,IL1RN,IRF5,ISG15,ITGAV,ITGB2,KLF4,LEP,LYZ,MAF,NR4A2,PEG10,PFKL,PLA2G2A,RET,S100A7,SAA1,SERPINE2,SLC1A3,SLFN5,SOCS3,SOX6,STAT1,STC2,THBS1,TIMP1,TNFRSF10B,TP53,WARS	 	
P2	 	CAT	-1.238	enzyme	Inhibited	-2.216	bias	-0.375	-1.180	1.08E-02	HIF1A,HLA-DRA,HMOX1,HSPA4,THBS1,TIMP1,TNFRSF10B,TP53,VCAM1	 	
P2	 	L-methionine	 	chemical - endogenous mammalian	 	-0.391	 	-0.066	-0.246	1.08E-02	DDIT3,EEF1D,GADD45B,HSPA5,IGFBP4,MAT2A,PCK2,SPP1,TOP2A	 	
P2	 	15-E2-isoketal modified phosphatidylethanolamine	 	chemical reagent	 	 	 	 	 	1.09E-02	DDIT3,HSPA5,VCAM1	 	
P2	 	ASCL2	-3.184	transcription regulator	 	 	 	 	 	1.09E-02	CTSD,CXCL10,EGR1	 	
P2	 	CLTC	1.572	other	 	 	 	 	 	1.09E-02	CD74,HLA-A,RRM2B	 	
P2	 	DGAT2	2.846	enzyme	 	 	 	 	 	1.09E-02	DGAT2,SCD,UCP2	 	
P2	 	LRP2	-3.623	transporter	 	 	 	 	 	1.09E-02	CA3,CTSB,DAB2	 	
P2	 	P2RY1	-1.423	g-protein coupled receptor	 	 	 	 	 	1.09E-02	FOS,LEP,VCAM1	 	
P2	 	RPS6KB2	-1.098	kinase	 	 	 	 	 	1.09E-02	CXCL10,ISG15,TP53	 	
P2	 	TARBP2	1.019	other	 	 	 	 	 	1.09E-02	MAF,RET,THBS1	 	
P2	 	TSPO	2.191	transmembrane receptor	 	 	 	 	 	1.09E-02	TSPO,VCAM1,VDAC1	 	
P2	 	diazepam	 	chemical drug	 	 	 	 	 	1.09E-02	FOS,PER1,TSPO	 	
P2	 	sanguinarine	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.09E-02	HMOX1,NQO1,TIMP1	 	
P2	 	TAZ	1.264	enzyme	 	 	 	 	 	1.10E-02	ADAMTS5,ANXA1,AOX1,CYR61,EDN1,KIT,KRT5,LCP1,PCLO,SEMA3C	 	
P2	 	EHF	2.820	transcription regulator	 	0.386	bias	0.292	-0.603	1.13E-02	FCER1A,GLB1,HIST1H4H,HMOX1,IL1RN,KIT,MS4A2,S100A7,S100A8,SAA1,SAA2,TIMP1,TNFRSF10B	 	
P2	 	MYOC	-8.959	other	Activated	2.200	bias	0.395	1.330	1.13E-02	ANXA1,DAB2,DDIT3,HOXA7,HSPA5,MBP,PHLDA2,SESN2,SFRP1,SLC7A11,SPP1,STC2,VAPA	 	
P2	 	Creb	 	group	 	0.100	bias	0.565	 	1.17E-02	ADIPOQ,ARPC5,CD14,COL8A1,CSF1R,CTSB,CXCL10,DUSP4,EGR1,ETV5,FAS,FCER1G,FOS,HLA-G,HSPB8,JUN,LEP,LMO4,MAT2A,MIF,MT-ND5,NMNAT2,NR4A1,PER1,RET,SOD1,SOX9	 	
P2	 	ASAH1	1.693	enzyme	 	-0.577	bias	-0.400	0.394	1.17E-02	CERS2,CERS6,NR4A1,NR4A2,SMPD1,TSPO	 	
P2	 	CCR1	2.913	g-protein coupled receptor	 	-0.816	bias	0.317	-1.593	1.17E-02	ATF4,CCR1,CTSS,FOS,ITGAV,SPP1	 	
P2	 	CSF1R	2.860	kinase	 	-0.555	bias	0.655	 	1.17E-02	CCND2,CSF1R,FOS,JUN,MSR1,VCAM1	 	
P2	 	THBS4	3.464	other	Activated	2.401	bias	0.294	1.696	1.17E-02	ATF4,CXCL10,HSPA5,HYOU1,TGFB2,VCAM1	 	
P2	 	arsenic	 	chemical toxicant	Activated	2.204	 	0.219	1.721	1.17E-02	FOS,FTH1,FTL,HIF1A,KEAP1,NQO1	 	
P2	 	diallyl disulfide	 	chemical - endogenous non-mammalian	 	1.966	bias	0.515	 	1.17E-02	ABCC3,GDF15,HMOX1,NFE2L2,NQO1,TP53	 	
P2	 	ozone	 	chemical toxicant	 	0.590	bias	0.721	 	1.17E-02	CXCL10,FOS,HMOX1,JUN,NFE2L2,SPP1	 	
P2	 	AK1	1.977	kinase	 	 	 	 	 	1.19E-02	AK1,ENO1,GAPDH,PKM	 	
P2	 	ARHGDIA	2.027	other	 	-0.152	bias	-0.277	0.397	1.19E-02	ESR2,FOS,RAC1,SCNN1B	 	
P2	 	CSF2RA	1.459	transmembrane receptor	 	0.152	bias	0.610	 	1.19E-02	CCND2,FOS,JUN,PIK3CG	 	
P2	 	PLCG1	1.004	enzyme	 	1.120	 	0.240	0.644	1.19E-02	CCND3,EGR1,FOS,THBS1	 	
P2	 	SKF-38393	 	chemical reagent	 	-0.320	bias	0.388	-1.079	1.19E-02	EGR1,FGF2,FOS,HSPA9	 	
P2	 	TRPV1	-1.231	ion channel	 	 	 	 	 	1.19E-02	CD4,FOS,HLA-DQB1,TP53	 	
P2	 	clasto-lactacystin beta-lactone	 	chemical - protease inhibitor	 	1.948	bias	0.721	 	1.19E-02	ATF4,DDIT3,GSTP1,TP53	 	
P2	 	gamma-linolenic acid	 	chemical - endogenous mammalian	 	0.000	 	-0.055	0.111	1.19E-02	HMOX1,PLIN2,PLIN5,THRSP	 	
P2	 	EBF1	-1.147	transcription regulator	 	1.977	bias	0.517	 	1.19E-02	ADIPOQ,CD160,CXCL10,GYS1,IGKC,INSR,MAPK10,MKNK2,PCK2,PIK3R1,PIK3R3,PPP1CA,PYGB,RHEB,SCD,SOCS3,STAT1	 	
P2	 	IL1	 	group	Activated	2.348	bias	0.461	-0.122	1.19E-02	ADAM17,ADAMTS5,AKR1C1/AKR1C2,APOE,APP,CSF1R,CTSB,CXCL10,CXCL9,EDN1,F2RL3,FAS,FOS,FTH1,HIF1A,HMOX1,IL1RN,ITGB2,JUN,KIT,LEP,LYZ,ODC1,PANX1,PDGFA,PLA2G2A,SAA1,SAA2,SDC4,SOCS3,SOX9,TGFBR1,TIMP1,TP53,TYMP,VCAM1	 	
P2	 	IDH1	1.248	enzyme	 	 	 	 	 	1.20E-02	ATF4,DDIT3,EDEM1,EGR1,LEP,MAPK10,TGFB2	 	
P2	 	BAX	1.470	transporter	Activated	2.975	bias	0.587	 	1.22E-02	CTSB,CTSD,CTSS,CXCL10,EDEM1,HLA-A,PDIA6,TIMP1,TRAF3	 	
P2	 	colchicine	 	chemical drug	 	-0.417	 	0.210	-0.974	1.22E-02	FAS,FOS,HIF1A,JUN,LEP,NQO1,SOX9,TMEM123,TUBA1B	 	
P2	 	miR-145-5p (and other miRNAs w/seed UCCAGUU)	 	mature microrna	 	-1.510	bias	-0.721	 	1.22E-02	CES1,FBXO28,KLF4,LAMP2,NDUFA4,SPTB,TPM3,UNG,USP46	 	
P2	 	FGF8	-3.620	growth factor	 	0.066	 	0.212	-0.687	1.24E-02	CRYAB,CYCS,DDAH2,ETV5,FGFR2,LMX1A,MKI67,RASD1,RPL26,SPP1,THBS1,TNXB,TSPYL5	 	
P2	 	ATM	1.132	kinase	 	-0.277	bias	0.545	 	1.24E-02	ADIPOQ,DUSP10,FAS,GADD45B,HMOX1,JUN,LEP,PSMC4,TNFRSF10B,TP53	 	
P2	 	Ca2+	 	chemical - endogenous mammalian	 	1.071	bias	0.391	-0.831	1.24E-02	AGER,APP,CCND2,CCND3,CD83,CYR61,DDIT3,DNASE1L3,EDN1,EGR1,FGF2,FGFR2,FOS,HSPA5,JUN,KCNG1,KLF4,KRT10,MSR1,NR1D1,NR4A1,ODC1,PEBP1,PER1,S100A7,S100A8,SPP1,SREBF2,TNFRSF10B	 	
P2	 	11,12-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	-1.400	bias	0.288	-2.034	1.27E-02	ADIPOQ,CYP4A11,NME1,PIK3CG,VCAM1	 	
P2	 	CYB5R4	2.071	enzyme	Inhibited	-2.201	bias	-0.649	 	1.27E-02	ACSL3,DDIT3,HMOX1,HSPA5,SCD	 	
P2	 	F10	-1.188	peptidase	 	-0.340	bias	0.266	-0.929	1.27E-02	CYR61,DUSP10,EGR1,MIF,VCAM1	 	
P2	 	L-buthionine (SR)-sulfoximine	 	chemical drug	 	1.980	 	0.240	1.504	1.27E-02	HMOX1,NFE2L2,NQO1,TNFRSF10B,TPO	 	
P2	 	finasteride	 	chemical drug	 	-0.447	bias	0.417	-1.380	1.27E-02	EDN1,FOS,HIF1A,SRD5A1,TGFB2	 	
P2	 	H89	 	chemical - kinase inhibitor	 	-0.252	bias	-0.490	1.713	1.28E-02	ADIPOQ,APP,CD14,CD83,EGR1,FGF2,FOS,GSTP1,HMOX1,LHCGR,NR4A1,NR4A2,S100A8,SIGMAR1,TXN,UCP2,VCAM1	 	
P2	 	GATA4	-17.523	transcription regulator	 	-0.714	 	0.134	-1.184	1.29E-02	ADORA1,CLDN1,CLSTN2,DAB2,EDN1,EPHX1,FGF2,FOS,HSPA5,KRT14,LHCGR,LOC102724428/SIK1,NR5A2,PLA2G2A,SGPL1,SOX9,SPP1,THBS4,TIMP1,VCAM1	 	
P2	 	Hbb-b1	 	transporter	 	1.300	bias	0.561	 	1.33E-02	C1QA,CD74,CXCL10,FTH1,FTL,IL10RA,IL2RG,VCAM1	 	
P2	 	RAC2	1.876	enzyme	 	 	 	 	 	1.33E-02	ALDOA,ANXA1,CD74,FOS,MIF,NR4A1,PKM,RAC1	 	
P2	 	miR-483-3p (miRNAs w/seed CACUCCU)	 	mature microrna	Inhibited	-2.154	bias	-0.721	 	1.33E-02	ERP29,HNRNPA0,MAPKAPK2,MKI67,PGAM1,RAN,SLC7A1,SOCS3	 	
P2	 	GCG	-14.412	other	 	-1.112	bias	0.376	-2.329	1.35E-02	ACKR3,ADIPOQ,AGER,BTG2,FOS,GSTP1,HK1,IGFBP4,ODC1,SREBF2,VCAM1	 	
P2	 	LDLR	1.033	transporter	 	0.169	 	-0.137	0.435	1.35E-02	ALCAM,APOB,APOE,CD68,DDIT3,EGR1,G6PD,HSPA5,MSR1,PSMB7,SPP1,UBE2D3,VCAM1	 	
P2	 	miR-125b-5p (and other miRNAs w/seed CCCUGAG)	 	mature microrna	Inhibited	-2.281	bias	-0.721	 	1.35E-02	AJUBA,ARID3B,CEBPG,GSS,IL1RN,JUN,MAZ,RABL6,SCD,SGPL1,TENM2,TP53,UBE2I	 	
P2	 	phorbol esters	 	chemical - other	 	0.706	bias	0.525	 	1.35E-02	ANXA1,APP,EGR1,FGFR2,FOS,JUN,ODC1,PDGFA,SLC12A2,SLC1A2,STMN2,TIMP1,TXN	 	
P2	 	NGF	2.114	growth factor	 	1.155	bias	0.414	-0.711	1.36E-02	ANXA2,APP,BTG2,CD83,DUSP4,EGR1,ETV5,FAS,FOS,HMOX1,JUN,KIF2A,MT-CO1,NR4A1,RAC1,SCN2A,SLC40A1,SOD1,SQSTM1,TNFRSF12A,TRPA1,TXN	 	
P2	 	MDM2	-1.080	transcription regulator	 	1.035	 	0.027	0.956	1.38E-02	ESR2,FCGRT,HIF1A,IL1RN,KRT14,LYZ,NDUFA1,TIMP1,TOP2A,TP53	 	
P2	 	NEDD9	-2.157	other	 	1.633	bias	0.680	 	1.40E-02	APP,FOS,GDF15,KIT,MKNK2,NRN1,PLIN2	 	
P2	 	oxaliplatin	 	chemical drug	 	1.355	 	0.240	0.735	1.40E-02	ANXA2,FAS,GDF15,SQSTM1,STAT1,TMSB10/TMSB4X,TP53	 	
P2	 	PRKD1	-1.035	kinase	 	1.408	bias	0.605	 	1.41E-02	ADIPOQ,AJUBA,CCND2,CD2,NR4A1,VCAM1	 	
P2	 	THBS1	-5.888	other	 	0.562	 	0.055	0.440	1.41E-02	ADCYAP1R1,EGR1,TGFB2,THBS1,TIMP1,TNFRSF10B	 	
P2	 	Ubiquitin	 	group	Inhibited	-2.219	bias	-0.262	-1.637	1.41E-02	CRYAB,DDIT3,FAM89B,HSPA4,HSPA5,HSPA9	 	
P2	 	ferulic acid	 	chemical - endogenous non-mammalian	 	-0.651	 	-0.190	-0.231	1.41E-02	APP,HMOX1,MKI67,PTPA,SOD1,TIMP1	 	
P2	 	leucine	 	chemical - endogenous mammalian	 	-1.408	 	0.055	-1.529	1.41E-02	ASNS,ATF4,CRAT,DDIT3,FOS,NR4A1	 	
P2	 	nitroarginine	 	chemical reagent	 	0.031	bias	0.360	-0.838	1.41E-02	CD53,EGR1,GCLM,HMOX1,NCAM1,SPP1	 	
P2	 	BRCA1	1.555	transcription regulator	Activated	2.401	 	0.216	1.553	1.41E-02	AK1,CTSD,DDIT3,EGR1,FAS,FKBP5,GADD45B,GDF15,HMOX1,HSPB1,KIT,KRT5,NFE2L2,NQO1,PLTP,RRM2B,S100A2,SERPINE2,STAT1,TP53,UBE2I	 	
P2	 	SIRT1	-1.079	transcription regulator	Inhibited	-2.598	 	0.068	-2.872	1.44E-02	ADAMTS5,ADIPOQ,CCND2,CTBP1,DDAH2,EDEM1,EIF2S2,H2AFZ,HMOX1,KIF5C,LEP,MAPT,MGAT1,MT-CO1,MTHFD1L,NLGN1,NR1D1,PCK2,PER1,PRMT3,SEC61A1,SFRP4,SLC7A11,TNFRSF10B,TP53,UCP2	 	
P2	 	TERT	-2.991	enzyme	 	0.000	bias	0.257	-0.510	1.48E-02	ASNS,BTBD11,COL5A2,DUSP6,FGF2,GLB1,HTRA1,IGFBP4,ISG15,ITGAV,MTHFD1L,PDGFC,PLTP,RAB9A,SPP1,TOX2,TP53	 	
P2	 	Interferon alpha	 	group	Activated	3.768	bias	0.469	1.247	1.51E-02	ANXA5,C3AR1,CCND2,CCND3,CCR1,CD209,CD83,CXCL10,CXCL9,FAS,FCER1A,FOS,GBP1,HLA-A,HLA-G,IGFBP4,IL10RA,IL17RA,IL1RN,INSR,IRF5,ISG15,MCRS1,RARRES3,RBX1,SIGLEC1,SLFN5,SOCS3,SPRY4,SREBF2,STAT1,TLR8,TRIOBP,TYMP,VCAM1,WARS,ZNRF3	 	
P2	 	(+)-fluprostenol	 	chemical drug	 	 	 	 	 	1.52E-02	FGF2,NR4A2	 	
P2	 	2-amino-3-phosphonopropionic acid	 	chemical - endogenous mammalian	 	 	 	 	 	1.52E-02	EGR1,FOS	 	
P2	 	3,4-dihydroxybenzaldehyde	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	CCND2,PARK7	 	
P2	 	ACS84	 	chemical reagent	 	 	 	 	 	1.52E-02	GCLM,HMOX1	 	
P2	 	AKAP13	-1.208	other	 	 	 	 	 	1.52E-02	FKBP5,FOS	 	
P2	 	ALPL	6.189	phosphatase	 	 	 	 	 	1.52E-02	ALPL,SPP1	 	
P2	 	Akr1b7	 	enzyme	 	 	 	 	 	1.52E-02	ADIPOQ,LEP	 	
P2	 	Ap1 gamma	 	group	 	 	 	 	 	1.52E-02	CD28,HLA-A	 	
P2	 	BCAT2	1.364	enzyme	 	 	 	 	 	1.52E-02	ADIPOQ,LEP	 	
P2	 	C1QL1	-6.162	other	 	 	 	 	 	1.52E-02	FOS,NR4A1	 	
P2	 	CCKAR	-16.533	g-protein coupled receptor	 	 	 	 	 	1.52E-02	EGR1,LEP	 	
P2	 	CHCHD4	2.390	enzyme	 	 	 	 	 	1.52E-02	HIF1A,MT-CO2	 	
P2	 	CIAO1	1.412	transcription regulator	 	 	 	 	 	1.52E-02	FAM96B,MMS19	 	
P2	 	CLDN4	-2.472	transmembrane receptor	 	 	 	 	 	1.52E-02	CLDN1,SLC31A1	 	
P2	 	CSNK1E	1.262	kinase	 	 	 	 	 	1.52E-02	APP,PER1	 	
P2	 	CTH	-1.174	enzyme	 	 	 	 	 	1.52E-02	DDIT3,HSPA5	 	
P2	 	DNAJC3	1.150	other	 	 	 	 	 	1.52E-02	ATF4,DDIT3	 	
P2	 	Dynamin	 	group	 	 	 	 	 	1.52E-02	FOS,ITGAV	 	
P2	 	EDEM1	2.916	enzyme	 	 	 	 	 	1.52E-02	DDIT3,HSPA5	 	
P2	 	EIF2B1	1.303	translation regulator	 	 	 	 	 	1.52E-02	ATF4,DDIT3	 	
P2	 	Esr1-Estrogen-Sp1	 	complex	 	 	 	 	 	1.52E-02	CTSD,FOS	 	
P2	 	FTMT	-2.352	enzyme	 	 	 	 	 	1.52E-02	FTH1,FTL	 	
P2	 	Fetal Hemoglobin	 	complex	 	 	 	 	 	1.52E-02	HIF1A,HMOX1	 	
P2	 	GFRA2	1.007	transmembrane receptor	 	 	 	 	 	1.52E-02	EGR1,FOSB	 	
P2	 	HIST1H1A	4.595	other	 	 	 	 	 	1.52E-02	FOS,GLB1	 	
P2	 	MCU	1.332	ion channel	 	 	 	 	 	1.52E-02	MT-CO1,NDUFA9	 	
P2	 	MEG3	-1.800	other	 	 	 	 	 	1.52E-02	GDF15,TP53	 	
P2	 	MOGAT1	2.131	enzyme	 	 	 	 	 	1.52E-02	CXCL10,TIMP1	 	
P2	 	NAA30	1.148	enzyme	 	 	 	 	 	1.52E-02	FAS,TNFRSF10B	 	
P2	 	NEU1	1.185	enzyme	 	 	 	 	 	1.52E-02	DGAT2,SREBF2	 	
P2	 	PFN1	2.118	other	 	 	 	 	 	1.52E-02	ANXA2,VCAM1	 	
P2	 	PIGT	1.907	enzyme	 	 	 	 	 	1.52E-02	GPAA1,PIGK	 	
P2	 	PPP1R1A	-1.231	phosphatase	 	 	 	 	 	1.52E-02	ERN1,HSPA5	 	
P2	 	PQQ cofactor	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	HMOX1,NFE2L2	 	
P2	 	PSMB5	1.650	peptidase	 	 	 	 	 	1.52E-02	GSTP1,PSMB2	 	
P2	 	RAB7A	1.944	enzyme	 	 	 	 	 	1.52E-02	EGR1,FOS	 	
P2	 	RING1	1.346	transcription regulator	 	 	 	 	 	1.52E-02	FOS,JUN	 	
P2	 	RPS7	1.416	other	 	 	 	 	 	1.52E-02	PIK3R1,TP53	 	
P2	 	SCN1B	1.459	ion channel	 	 	 	 	 	1.52E-02	FOS,SCN2A	 	
P2	 	TUBB1	-2.421	other	 	 	 	 	 	1.52E-02	TUBB,TUBB2A	 	
P2	 	Trk Receptor	 	group	 	 	 	 	 	1.52E-02	DUSP6,EDN1	 	
P2	 	VDAC1	2.033	ion channel	 	 	 	 	 	1.52E-02	APP,VDAC1	 	
P2	 	acriflavine	 	chemical toxicant	 	 	 	 	 	1.52E-02	ADIPOQ,SOCS3	 	
P2	 	actinomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	IGFBP4,SAA1	 	
P2	 	ampelopsin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	HMOX1,HSPA5	 	
P2	 	atipamezole	 	chemical drug	 	 	 	 	 	1.52E-02	EGR1,FOS	 	
P2	 	cyclohexanecarboxylic acid	 	chemical reagent	 	 	 	 	 	1.52E-02	NCAM1,SYP	 	
P2	 	dobutamine	 	chemical drug	 	 	 	 	 	1.52E-02	HMOX1,LEP	 	
P2	 	exemestane	 	chemical drug	 	 	 	 	 	1.52E-02	HMOX1,NQO1	 	
P2	 	ezatiostat	 	chemical drug	 	 	 	 	 	1.52E-02	ABCC1,GCLM	 	
P2	 	kawain	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	CYP3A5,HMOX1	 	
P2	 	methylamphotericin B	 	chemical drug	 	 	 	 	 	1.52E-02	SPP1,TIMP1	 	
P2	 	methysticin	 	chemical reagent	 	 	 	 	 	1.52E-02	CYP3A5,HMOX1	 	
P2	 	myristoylated PKCzeta pseudosubstrate peptide inhibitor	 	chemical - kinase inhibitor	 	 	 	 	 	1.52E-02	LHCGR,VCAM1	 	
P2	 	natamycin	 	chemical drug	 	 	 	 	 	1.52E-02	SPP1,TIMP1	 	
P2	 	nitromifene	 	chemical reagent	 	 	 	 	 	1.52E-02	PPP1R9B,SYP	 	
P2	 	oxonic acid	 	chemical drug	 	 	 	 	 	1.52E-02	CYP3A5,POR	 	
P2	 	phenol derivative	 	chemical toxicant	 	 	 	 	 	1.52E-02	HMOX1,NFE2L2	 	
P2	 	phloretin	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	ADIPOQ,HMOX1	 	
P2	 	pituitary adenylate cyclase-activating polypeptide	 	biologic drug	 	 	 	 	 	1.52E-02	CCND2,CCND3	 	
P2	 	potassium channel	 	group	 	 	 	 	 	1.52E-02	FOS,JUN	 	
P2	 	riociguat	 	chemical drug	 	 	 	 	 	1.52E-02	SPP1,TIMP1	 	
P2	 	silver nitrate	 	chemical drug	 	 	 	 	 	1.52E-02	HMOX1,SAA1	 	
P2	 	trimethyloxamine	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.52E-02	ATF4,DDIT3	 	
P2	 	vaccenic acid	 	chemical - endogenous mammalian	 	 	 	 	 	1.52E-02	PLIN2,PLIN5	 	
P2	 	yohimbine	 	chemical drug	 	 	 	 	 	1.52E-02	EGR1,FOS	 	
P2	 	FLI1	1.211	transcription regulator	 	1.414	bias	0.432	0.278	1.55E-02	AIP,CCND3,CSF1R,EGR1,HSPA8,IMP4,NOL6,RPL18,SNU13	 	
P2	 	MAT1A	-5.460	enzyme	 	-0.625	 	-0.172	-0.250	1.57E-02	CYP4A11,EGR1,FAS,SAA1,SOD1	 	
P2	 	ZBTB17	1.805	transcription regulator	 	 	 	 	 	1.57E-02	BTG3,DDIT3,EGR1,JUN,RRM2B	 	
P2	 	fludarabine	 	chemical drug	 	0.626	 	-0.042	0.719	1.57E-02	FAS,HIF1A,STAT1,TNFRSF10B,TP53	 	
P2	 	pifithrin alpha	 	chemical reagent	Inhibited	-2.216	bias	-0.446	-1.227	1.57E-02	FAS,HMOX1,SQSTM1,TNFRSF10B,TP53	 	
P2	 	Cd2+	 	chemical toxicant	 	1.067	bias	0.577	 	1.57E-02	DDIT3,FOS,HMOX1,SOD1	 	
P2	 	IFNA10	-1.656	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA14	-2.955	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA21	1.567	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA5	-2.910	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA6	-2.985	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA7	-1.063	cytokine	 	 	 	 	 	1.57E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	Nos	 	group	 	-0.283	bias	0.499	-1.271	1.57E-02	EGR1,FOS,HMOX1,TIMP1	 	
P2	 	Srebp	 	group	 	1.000	bias	0.721	 	1.57E-02	FOS,G6PD,PGD,UCP2	 	
P2	 	beta-1,3-glucan	 	chemical drug	 	1.000	bias	0.515	 	1.57E-02	FGF1,FGF2,ITGAV,PDGFA	 	
P2	 	spermidine	 	chemical - endogenous mammalian	 	1.000	 	0.197	0.607	1.57E-02	FOS,HMOX1,OAZ1,ODC1	 	
P2	 	CUL4B	1.354	other	Inhibited	-2.646	bias	-0.432	-1.502	1.62E-02	EIF3I,GLO1,HSPA9,NME1,SOD1,TPM3,UBXN1	 	
P2	 	SUMO2	1.608	enzyme	 	-1.912	 	-0.109	-1.625	1.62E-02	CCND2,CXCL16,HLA-G,HMGA1,HSPA8,ISG15,LAMP3	 	
P2	 	amiodarone	 	chemical drug	 	0.816	bias	0.384	-0.125	1.62E-02	CA3,CYP4A11,GRN,HMOX1,ME1,SCD,SLCO2B1	 	
P2	 	anandamide	 	chemical - endogenous mammalian	 	1.460	 	0.240	0.884	1.62E-02	FGF2,FOS,HSPA5,NCSTN,PLIN2,STIP1,TP53	 	
P2	 	CTGF	-2.295	growth factor	 	-0.788	bias	0.390	-2.220	1.62E-02	ADAMTS5,COL8A1,DAD1,EGR1,ENO1,HIF1A,JUN,LHCGR,PTGFR,RAMP2,SDC4,SFRP4,TIMP1,TP53	 	
P2	 	INSIG1	1.586	other	Inhibited	-3.031	bias	-0.706	 	1.62E-02	AACS,ALOX5AP,APOE,CD68,CXCL10,G6PD,HLA-DQA1,HMGCS1,PLIN2,PMVK,S100A8,SCD,SREBF2,UCP2	 	
P2	 	4-phenylbutyric acid	 	chemical - endogenous mammalian	 	-0.537	 	0.064	-0.742	1.64E-02	DDIT3,EIF2S2,EPHX1,ERN1,HIF1A,HLA-A,HSPA4,HSPA5,LYPLA1,PARK7,PSMA3	 	
P2	 	cadmium	 	chemical toxicant	 	1.141	bias	0.284	0.314	1.64E-02	CUBN,EPHX1,ESR2,HIF1A,HLA-DQB1,HMOX1,HNRNPK,HSPA5,JUN,TIMP1,TP53	 	
P2	 	ABCC1	3.860	transporter	 	 	 	 	 	1.65E-02	CYBB,NFE2L2,NQO1	 	
P2	 	ATF5	9.101	transcription regulator	 	 	 	 	 	1.65E-02	GAS5,SAA1,SAA2	 	
P2	 	BACE1	1.092	peptidase	 	 	 	 	 	1.65E-02	APP,MBP,SCN2A	 	
P2	 	DEPTOR	1.167	other	 	 	 	 	 	1.65E-02	CXCL10,CXCL9,VCAM1	 	
P2	 	L-type Calcium Channel	 	complex	 	 	 	 	 	1.65E-02	APOE,EGR1,FOS	 	
P2	 	MDL 28170	 	chemical toxicant	 	 	 	 	 	1.65E-02	APP,PRNP,TP53	 	
P2	 	N-propyl bromide	 	chemical reagent	 	 	 	 	 	1.65E-02	GCLM,HMOX1,NQO1	 	
P2	 	NCX-4040	 	chemical drug	 	 	 	 	 	1.65E-02	GCLM,GSTP1,NQO1	 	
P2	 	Presenilin	 	group	 	 	 	 	 	1.65E-02	APP,INSR,PRNP	 	
P2	 	RP 73401	 	chemical toxicant	 	 	 	 	 	1.65E-02	BTG2,EGR1,STAT1	 	
P2	 	SHANK3	-1.320	other	 	 	 	 	 	1.65E-02	NLGN1,PCLO,SYP	 	
P2	 	SOAT1	1.257	enzyme	 	 	 	 	 	1.65E-02	APP,DDIT3,SREBF2	 	
P2	 	allyl isothiocyanate	 	chemical toxicant	 	 	 	 	 	1.65E-02	FOS,HMOX1,NFE2L2	 	
P2	 	aplidine	 	biologic drug	 	 	 	 	 	1.65E-02	FOS,FOSB,JUN	 	
P2	 	sphingosylphosphocholine	 	chemical - endogenous non-mammalian	 	 	 	 	 	1.65E-02	DUSP6,FOS,JUN	 	
P2	 	GLI1	-1.294	transcription regulator	 	1.250	bias	0.586	 	1.65E-02	ARPC5,CCND2,DEGS1,EPB41L4B,FAS,FHL1,FUCA2,KLF4,MRPS6,PDGFA,PHLDA2,RAP2A,RPL30,S100A7,SFRP1,SH2B3,SH3GLB1,SOX18,SOX6,SOX9,SPP1,TNFRSF10B,TP53	 	
P2	 	4-hydroxytamoxifen	 	chemical drug	 	1.287	bias	0.268	0.180	1.65E-02	CAPNS1,CHST2,CNBP,COL16A1,CTSD,DYNLL1,EIF5A,FOS,GM2A,HDGF,MKI67,MPC1,OGT,RHOBTB2,TNPO1,TP53,TRIM16,ZNF91	 	
P2	 	KN 93	 	chemical - kinase inhibitor	 	0.391	bias	-0.548	 	1.66E-02	CD83,FOS,NR4A1,NR4A2,PEA15,TP53	 	
P2	 	bafilomycin A1	 	chemical drug	 	1.664	bias	0.273	0.999	1.66E-02	CD151,CXCL10,DDIT3,SLC7A1,SQSTM1,TRIB3	 	
P2	 	caspase	 	group	 	0.391	bias	0.605	 	1.66E-02	APP,CCND2,CCND3,CD14,GLUL,THBS1	 	
P2	 	PDX1	-11.643	transcription regulator	 	-0.878	 	0.137	-1.466	1.69E-02	ACTG1,AKR1B1,ANXA2,ARRDC4,ATG9A,ATP5J,DUSP6,EGR1,FGF1,FGF2,GCLM,GOT1,GRN,HK1,JUN,MAPT,MT-ND1,NQO1,NR5A2,NUPR1,SPP1	 	
P2	 	N-methyl-D-aspartate	 	chemical reagent	 	-0.784	bias	0.426	-1.947	1.72E-02	APP,EGR1,FOS,HSPA5,MAP1B,SAA1,SLC1A2,SLC1A3	 	
P2	 	VitaminD3-VDR-RXR	 	complex	 	0.901	bias	0.470	-0.414	1.72E-02	CD14,CST6,CXCL10,HOXA10,KLF4,PDGFA,SPP1,TGFB2	 	
P2	 	chloroquine	 	chemical drug	 	1.475	 	-0.048	1.608	1.72E-02	APP,CTSD,CXCL10,HIF1A,PRNP,SOCS3,SQSTM1,TXN	 	
P2	 	CLDN7	1.345	other	 	0.075	 	0.012	0.028	1.73E-02	APLP2,APOE,ARHGDIB,ATP5G1,CD68,CKAP4,DPM3,FADS3,HIST2H2AC,MRPS15,NNMT,PLGRKT,PRNP,RPL29,SLC25A22,TRIM31	 	
P2	 	CLEC11A	-1.216	growth factor	 	 	 	 	 	1.74E-02	ALDOA,ALOX5AP,ANXA1,CD74,CPA3,FOS,LHCGR,MIF,NR4A1	 	
P2	 	glutathione	 	chemical - endogenous mammalian	Inhibited	-2.804	 	-0.144	-2.400	1.74E-02	ABCC1,ASS1,DDIT3,GNL3,HIF1A,HMOX1,SLC7A11,TNFRSF10B,VCAM1	 	
P2	 	TNFSF10	1.035	cytokine	Activated	3.113	 	0.131	2.676	1.75E-02	CD14,CTSB,FOS,FTH1,HLA-A,IL1RN,ISG15,JUN,STAT1,TAF6,TIMP1,TNFRSF10B,TP53	 	
P2	 	mir-210	 	microrna	Inhibited	-3.039	bias	-0.658	 	1.75E-02	ABCC3,ALDH5A1,GDE1,ISCU,KCMF1,KIAA0930,MNT,NCAM1,NDUFA4,PSAP,SDF2,TNPO1,UBQLN1	 	
P2	 	GH1	-3.009	growth factor	 	-0.366	 	0.186	-1.064	1.75E-02	ABCC1,AKR1B1,APOE,ATF4,CA3,CCND3,COMT,DDIT3,EGR1,FOS,FTH1,GSTP1,HADHB,INSR,JUN,MT-CO2,MT-CYB,MT-ND3,MT-ND5,NR2F6,SHMT2,SOCS3,SOD1,SPP1	 	
P2	 	RAC1	1.647	enzyme	 	0.817	bias	0.484	-0.693	1.76E-02	FAS,FGF2,FOS,HIF1A,HMOX1,HSPB1,JUN,KRT14,KRT6B,RAC1,SOX6,SOX9,STAT1,VCAM1	 	
P2	 	TREM1	-4.721	transmembrane receptor	 	1.547	bias	0.382	-0.279	1.84E-02	ACKR3,ACSL3,ARRDC4,ASNS,ASPH,CD14,CD83,CXCL10,DUSP4,EDN1,EGR1,GADD45B,GCLM,GIPR,ISG15,LAMP3,NR4A2,OSGIN1,PHLDA2,SLC1A3,SPP1,TBC1D7,THBS1	 	
P2	 	IgG	 	complex	 	-1.857	bias	-0.336	-0.420	1.87E-02	APOE,APP,CCND2,DDIT3,DEGS1,EDN1,FCGR2A,FOSB,GUK1,HDGF,HSPA5,HSPB1,IL1RN,ISG15,KRT10,PEA15,PHLDA2,TRIM16,TUBB2A,VCAM1	 	
P2	 	Hsp27	 	group	 	-1.000	 	0.070	-1.181	1.87E-02	CD14,CSF1R,FOS,GBA,MAPT,PLA2G2A,PPP1R1B	 	
P2	 	KRT14	9.838	other	 	 	 	 	 	1.87E-02	CXCL14,DSG1,GJB2,GJB6,HSPA5,KRT5,KRT6B	 	
P2	 	carbamylcholine	 	chemical drug	Inhibited	-2.592	bias	0.370	-3.551	1.87E-02	APOE,APP,BTG2,EGR1,FOS,JUN,NR4A1	 	
P2	 	hexamethylene bisacetamide	 	chemical reagent	 	-1.414	 	-0.097	-1.158	1.87E-02	ALAS1,CREG1,HSPA8,IMP4,NOL6,RPL18,SNU13	 	
P2	 	FGF19	-4.923	growth factor	Inhibited	-2.000	 	-0.060	-1.880	1.87E-02	APOE,BTG3,EGR1,FOS,G0S2,HLA-DQB1,IL1RN,LEP,SCD,SLC2A5,TCEA1,THRSP	 	
P2	 	MAP4K4	1.761	kinase	Inhibited	-3.357	bias	-0.721	 	1.88E-02	ALDH4A1,GLUL,GOT1,GYS1,HADHB,LDHB,NDUFA11,NDUFAB1,NDUFS4,NDUFS8,PDXP,PEX3,PGAM1,SCD,UCK1	 	
P2	 	GPD1	1.478	enzyme	 	 	 	 	 	1.90E-02	ALPL,ANXA2,APP,ASNS,C6,CD63,FADS3,FAM129A,MTHFD1L,NQO1,PFKFB3,PSAT1,SERPINE2	 	
P2	 	SPP1	6.013	cytokine	Activated	3.809	bias	0.459	1.863	1.90E-02	ADIPOQ,CAPNS1,COX7A2L,FGFR2,FOS,HMOX1,ITGAV,MECR,NDUFA9,NDUFS4,NDUFS8,PDGFA,PGD,PIK3R1,POR,SOX9,SPP1,TGFBR1,TIMP1,TP53,VAT1	 	
P2	 	KISS1	-1.663	other	 	-1.270	bias	0.328	-1.989	1.91E-02	EGR1,FOS,GSTP1,MT-ND2,NFE2L1	 	
P2	 	SEMA7A	-3.045	transmembrane receptor	 	1.342	bias	0.721	 	1.91E-02	CTSB,CTSS,EGR1,FGF2,TIMP1	 	
P2	 	ceruletide	 	biologic drug	 	1.949	bias	0.504	 	1.91E-02	ACTG1,ATF4,DDIT3,HMOX1,HSPA5	 	
P2	 	IL1R1	-1.324	transmembrane receptor	 	0.000	bias	0.464	-1.014	1.94E-02	ABCC1,ABCC3,CXCL10,EGR1,FAM89B,FOS,LEP,SAA1,TIMP1	 	
P2	 	ADRA1B	-4.060	g-protein coupled receptor	 	 	 	 	 	1.94E-02	ADRA1A,CSRP2,EGR1,FOS,JUN,LEP,NR4A1,NR4A2	 	
P2	 	LCK	1.068	kinase	 	-0.063	bias	0.317	-0.761	1.96E-02	ANXA1,CD2,CD4,FOS,ITGB2,JUN	 	
P2	 	ciprofibrate	 	chemical drug	 	0.633	 	-0.030	0.759	2.01E-02	ANXA2,APOB,CBR1,CCND2,CD63,CIDEA,CRAT,CSTB,CYP4A11,GOT1,GSTP1,LHPP,NPC2,PLIN2,RPL12,SCD,SLCO2B1,SQSTM1	 	
P2	 	ID3	2.008	transcription regulator	 	-0.587	 	-0.115	-0.149	2.01E-02	ADIPOQ,CCND2,CD83,DUSP10,DUSP4,FCER1G,GADD45B,GNL3,HIF1A,IL10RA,IL20RB,IRF5,LMO4,MAF,NR4A1,PIK3R1,SOCS3,TOX2,TP53,TRAF3,ZBTB16	 	
P2	 	24-hydroxycholesterol	 	chemical - endogenous mammalian	 	-0.125	 	0.144	-0.407	2.02E-02	APOE,APP,HSPA5,SREBF2	 	
P2	 	ATP2A2	1.324	transporter	 	-1.000	bias	-0.432	-0.135	2.02E-02	APP,DDIT3,DGAT2,SCD	 	
P2	 	CBS/CBSL	1.067	enzyme	Inhibited	-2.000	 	-0.144	-1.712	2.02E-02	APOB,EEF1D,GOT1,UNG	 	
P2	 	DDX5	-1.216	enzyme	 	 	 	 	 	2.02E-02	FOS,HTRA1,JUN,TP53	 	
P2	 	IFNA16	 	cytokine	 	 	 	 	 	2.02E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	IFNA8	1.655	cytokine	 	 	 	 	 	2.02E-02	CXCL10,CXCL9,ISG15,RARRES3	 	
P2	 	KAT2A	1.191	enzyme	 	 	 	 	 	2.02E-02	CCND2,EDEM1,HSPA5,TNFRSF10B	 	
P2	 	L-685,458	 	chemical - protease inhibitor	 	-1.965	bias	-0.625	 	2.02E-02	APP,LAMP1,PTPRK,TP53	 	
P2	 	PDGFRA	1.089	kinase	 	 	 	 	 	2.02E-02	DAB2,FOS,KIT,TP53	 	
P2	 	PLC	 	group	 	-0.152	bias	0.601	 	2.02E-02	CXCL10,FOS,NR4A1,ODC1	 	
P2	 	S1PR2	1.297	g-protein coupled receptor	 	0.048	bias	0.625	 	2.02E-02	FOS,JUN,TIMP1,VCAM1	 	
P2	 	TCF7L1	1.005	transcription regulator	 	0.000	 	-0.206	0.412	2.02E-02	CCND2,JUN,KLF4,STMN2	 	
P2	 	THRAP3	1.073	transcription regulator	 	1.067	bias	-0.601	 	2.02E-02	ADIPOQ,APLP2,CA3,PEG10	 	
P2	 	cobalt	 	chemical toxicant	 	0.000	bias	0.618	 	2.02E-02	FGF2,HIF1A,PFKFB1,PFKFB3	 	
P2	 	epothilone B	 	chemical drug	 	-1.067	 	0.048	-1.163	2.02E-02	BTG2,FAS,THBS1,TOP2A	 	
P2	 	statin	 	chemical drug	 	-0.152	 	-0.166	0.177	2.02E-02	CYBB,LEP,SREBF2,TXNRD1	 	
P2	 	mycophenolic acid	 	chemical drug	 	0.528	bias	0.460	-1.064	2.03E-02	CCND2,CCND3,CD63,CLDN1,CYBB,CYR61,EDN1,GBP1,GNL3,HSPA5,KRT6B,MYL12A	 	
P2	 	WNT3A	-5.326	cytokine	 	-1.317	bias	0.298	-2.796	2.05E-02	ALPL,APP,ARRDC4,CCND2,CD68,CYR61,EDN1,ENG,ETV5,JUN,MESP1,NCAM1,PDGFA,PLIN1,RFLNB,SDC4,SIM1,SLC7A1,SLC7A2,SOX9,TGFB2,THBS1,TMEM2,TNXB,TRIB3,VCAM1	 	
P2	 	MAPK1	1.392	kinase	 	-0.548	 	-0.027	-0.411	2.08E-02	ADAM12,ADAM17,APOE,CAPN2,CHST2,COX17,CSTA,CTSB,DAB2,EGR1,ERP29,FLNC,FOS,FOSB,GBP1,GNG2,HMOX1,IL1RN,ISG15,ITGAV,JUN,LAMP3,LZTS2,MBP,NFE2L2,NRN1,NUPR1,PTPRK,SPP1,SPRY4,STAT1,TNFRSF10B,TP53,UBE2I,UTP18	 	
P2	 	HIPK2	-1.291	kinase	 	0.412	 	0.225	-0.290	2.08E-02	ALOX5AP,CCND2,CIDEA,CITED1,EGR1,FECH,HIF1A,RAC1,SPTB,TP53	 	
P2	 	CLOCK	1.489	transcription regulator	 	 	 	 	 	2.13E-02	C1QBP,CBR1,DDIT3,FKBP5,GADD45B,HLA-DQB1,HSPH1,KCND3,MKNK2,PAFAH1B2,PER1,POMGNT1,POR,PRELID3B,SEL1L,SLC1A2,ST6GALNAC4,TMED3	 	
P2	 	ATP7B	-1.319	transporter	 	0.000	 	0.097	-0.239	2.14E-02	AACS,APP,HIST1H1C,HMGCS1,MSMO1,SREBF2,THRSP	 	
P2	 	K+	 	chemical - endogenous mammalian	 	-0.788	bias	0.280	-1.461	2.14E-02	EGR1,FOS,GAPDH,JUN,NR4A1,NR4A2,TP53	 	
P2	 	alvocidib	 	chemical drug	 	-0.440	bias	-0.569	 	2.14E-02	AIF1,CCND3,FOS,RHOBTB2,TCEA1,TP53,TXN	 	
P2	 	NOTCH1	1.291	transcription regulator	 	-0.622	 	0.097	-1.074	2.16E-02	AKR1C1/AKR1C2,CCND2,CCND3,CD14,CD68,CSF1R,CTSG,CYR61,FCER1G,FCGR2A,FGF2,FOS,FOSB,GAA,GRN,IGFBP4,KRT14,LFNG,NHLH1,PTPRK,S100A1,SPP1,SYP,TGFB2,TP53	 	
P2	 	dextran sulfate	 	chemical drug	 	-0.415	bias	0.366	-1.365	2.16E-02	ANLN,CD14,CD209,CD74,CD83,CFH,EFEMP2,ENG,FGF1,HMOX1,ISG15,LCP1,MKI67,MSR1,NQO1,PDGFA,S100A8,SOCS3,SPON2,STEAP3,TGFB2,THBS1,THBS4,TOP2A,VCAM1	 	
P2	 	GNRH1	1.130	other	 	-0.640	bias	0.340	-1.623	2.16E-02	APP,DUSP4,EGR1,FOS,FOSB,JUN,PPP1R9B,RPLP1,RPSA	 	
P2	 	RHO	-2.198	g-protein coupled receptor	 	-1.667	 	0.103	-1.976	2.16E-02	APP,C1QA,CD74,CSF1R,CTSS,FOS,GNB1,HIST1H1C,NCAM1	 	
P2	 	TLR9	-3.873	transmembrane receptor	 	0.344	bias	0.573	 	2.16E-02	ARRDC4,CD83,CERS6,CPM,CXCL10,CXCL9,EDN1,EGR1,FAS,GADD45B,HMOX1,IL10RA,ISG15,LAIR1,LAMP2,NR4A1,NSMAF,PFKFB3,S100A8,SGPL1,SMPD1,SOCS3,STAT1,TIMP1	 	
P2	 	apigenin	 	chemical - endogenous non-mammalian	 	-1.761	bias	-0.518	 	2.17E-02	CCND2,DGAT2,DVL1,DVL3,FOS,GCLM,HIF1A,HMOX1,TNFRSF10B,TP53,VCAM1	 	
P2	 	nitroprusside	 	chemical drug	 	-0.119	 	0.125	-0.467	2.19E-02	ACTN1,DUSP6,EGR1,FAS,FOS,HMOX1,SLC1A4,TP53	 	
P2	 	SLC25A13	1.846	transporter	 	 	 	 	 	2.22E-02	ALPL,ANXA2,APP,ASNS,C6,CD63,FADS3,FAM129A,MTHFD1L,NQO1,PFKFB3,PSAT1,SERPINE2	 	
P2	 	bezafibrate	 	chemical drug	 	0.537	bias	0.504	 	2.22E-02	ACAD11,ACOT4,ADIPOQ,APOE,HADHB,HSPA5,LEP,MT-CO1,NPC2,PEX3,SCD,TSPO,UCP2	 	
P2	 	diethylstilbestrol	 	chemical drug	 	-1.057	bias	0.304	-2.304	2.27E-02	ADIPOQ,ALPL,ARHGDIB,BCAT1,C1QA,CD14,CLSTN2,DUSP6,EGR1,ESR2,FAS,FMO1,FOS,GJB2,GSPT1,HLA-A,HOXA10,IGSF6,KLF4,LMO4,PDGFA,RPN2,S100A8,SDF2	 	
P2	 	IL17A	-5.159	cytokine	 	1.596	bias	0.518	 	2.27E-02	CD14,CD68,CD83,CYR61,FAS,FGF2,FMO1,FOS,HSPB8,IL17RA,IL1RN,ISG15,JUN,LEP,PLXNB2,PTGFR,S100A7,S100A8,SOCS3,TIMP1,TYMP,VCAM1,YWHAG	 	
P2	 	ABCB4	-1.571	transporter	 	-1.777	bias	-0.673	 	2.28E-02	CXCL10,NR5A2,PDGFA,SPP1,TGFB2,TIMP1	 	
P2	 	ALDH1A2	-1.371	enzyme	 	-0.557	bias	-0.256	0.060	2.28E-02	CYR61,FGF2,IGFBP4,KIT,SPP1,TIMP1	 	
P2	 	CNOT7	1.495	transcription regulator	 	 	 	 	 	2.28E-02	CLDN1,CSTA,ISG15,SLC14A1,SLC7A11,STAT1	 	
P2	 	IFIH1	1.448	enzyme	 	1.709	bias	0.628	 	2.28E-02	CD4,CXCL10,EGR1,FAS,ISG15,PTPRJ	 	
P2	 	fluvoxamine	 	chemical drug	 	 	 	 	 	2.28E-02	ADIPOQ,CCR1,FOS,GAPDH,GLB1,NR4A2	 	
P2	 	9Z,11E-octadecadienoic acid	 	chemical - endogenous non-mammalian	 	0.277	 	-0.031	0.347	2.30E-02	CYP4A11,IL10RA,SORBS1,THBS1,UCP2	 	
P2	 	CX3CL1	-1.021	cytokine	 	0.447	bias	0.446	-0.550	2.30E-02	FGF2,HIF1A,HMOX1,MSR1,TIMP1	 	
P2	 	IFNK	-1.227	cytokine	 	 	 	 	 	2.30E-02	CD83,CXCL10,CXCL9,RARRES3,STAT1	 	
P2	 	MST1	1.709	growth factor	 	-0.651	bias	-0.262	-0.071	2.30E-02	FAS,FOS,IL1RN,MSR1,SPP1	 	
P2	 	NAMPT	1.116	cytokine	 	1.400	bias	0.470	0.366	2.30E-02	CXCL10,NPY1R,PEG10,TGFB2,TP53	 	
P2	 	NTRK1	-2.940	kinase	Inhibited	-2.000	bias	0.625	 	2.30E-02	EGR1,FOS,NR4A1,RET,TP53	 	
P2	 	miR-30a-3p (and other miRNAs w/seed UUUCAGU)	 	mature microrna	 	1.342	bias	-0.721	 	2.30E-02	CYR61,RAB8B,SLC7A6,THBS1,TMEM2	 	
P2	 	(-)-epicatechin gallate	 	chemical - endogenous non-mammalian	 	 	 	 	 	2.34E-02	GDF15,PPP1CA,SPP1	 	
P2	 	4-(2-aminoethyl)benzenesulfonylfluoride	 	chemical - protease inhibitor	 	 	 	 	 	2.34E-02	DDIT3,HMOX1,HSPA5	 	
P2	 	6-aminonicotinamide	 	chemical reagent	 	 	 	 	 	2.34E-02	G6PD,HIF1A,HSPA5	 	
P2	 	8,9-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	 	 	 	 	2.34E-02	ADIPOQ,NME1,PIK3CG	 	
P2	 	AGRP	-4.239	other	 	 	 	 	 	2.34E-02	FOS,LEP,PSMA4	 	
P2	 	APH1A	1.156	peptidase	 	 	 	 	 	2.34E-02	APP,NCSTN,TP53	 	
P2	 	HTR7	-8.283	g-protein coupled receptor	 	 	 	 	 	2.34E-02	FOS,STAB1,THBS1	 	
P2	 	SLC18A2	1.848	transporter	 	 	 	 	 	2.34E-02	ADCY1,DYNLL1,PSAP	 	
P2	 	TAF6	2.341	transcription regulator	 	 	 	 	 	2.34E-02	GAPDH,HLA-DRA,JUN	 	
P2	 	aurothioglucose	 	chemical drug	 	 	 	 	 	2.34E-02	HMOX1,LEP,NQO1	 	
P2	 	betaine	 	chemical - endogenous mammalian	 	 	 	 	 	2.34E-02	DDIT3,FGF2,HSPA5	 	
P2	 	desoxycorticosterone	 	chemical - endogenous mammalian	 	 	 	 	 	2.34E-02	CYBB,FOS,SPP1	 	
P2	 	immune complex	 	complex	 	 	 	 	 	2.34E-02	IL1RN,SOCS3,VCAM1	 	
P2	 	prodigiosin	 	chemical toxicant	 	 	 	 	 	2.34E-02	DDIT3,HSPA5,TNFRSF10B	 	
P2	 	racemic flurbiprofen	 	chemical drug	 	 	 	 	 	2.34E-02	APP,THRSP,TP53	 	
P2	 	voltage-gated calcium channel	 	complex	 	 	 	 	 	2.34E-02	CCND2,NR4A2,PTPRC	 	
P2	 	Salmonella enterica serotype abortus equi lipopolysaccharide	 	chemical toxicant	 	1.389	bias	0.721	 	2.35E-02	ACKR3,ARRDC4,ASNS,EDN1,EGR1,G0S2,GADD45B,GBP1,GJB2,ISG15,LAMP3,NR4A2,OSGIN1,PHLDA2,PIM3,PTX3,SIAH2,SLC1A3,SOCS3,THBS1	 	
P2	 	ELAVL1	-1.096	other	 	1.726	bias	0.529	 	2.37E-02	CALM1 (includes others),CD83,FLNA,FOS,GSS,HMOX1,HSPA2,PSMB4,RPN2,TP53,TRIOBP	 	
P2	 	CD44	1.244	enzyme	 	0.972	bias	0.473	-0.763	2.37E-02	ACKR3,CCND2,CD63,CIDEA,COL5A2,DDIT3,FAS,FKBP4,FKBP5,IL1RN,ITGAV,JUN,KDM1B,MYBBP1A,SDC4,SPP1,THBS1,TLR8,VCAM1,VCP,WBP2	 	
P2	 	LGALS3	1.205	other	 	0.981	 	0.154	0.496	2.40E-02	ADIPOQ,AGER,CCR1,COL5A2,DUSP6,ITGAV,LAMP1,MSR1,RAC1,SAA1,SOCS3,VCAM1	 	
P2	 	MET	-1.804	kinase	 	-1.267	bias	0.517	 	2.40E-02	CCND2,DAB2,EDN1,FOS,HMOX1,HSPB1,JUN,KLF4,RILPL1,SOCS3,SOD1,SPP1	 	
P2	 	MYB	-1.013	transcription regulator	 	1.964	bias	0.550	 	2.40E-02	ATP2B1,CBX4,CD4,HSPA5,HSPA8,JUN,KIT,KLF4,MAT2A,MTSS1,SLC1A5,SPP1	 	
P2	 	N-nitro-L-arginine methyl ester	 	chemical drug	 	0.965	 	0.046	0.825	2.40E-02	ADIPOQ,CD68,CD83,CYBB,FAS,HMOX1,ITGAV,MAP1B,SOD1,TIMP1,TP53,VCAM1	 	
P2	 	lysophosphatidic acid	 	chemical - other	 	-0.963	bias	0.517	 	2.40E-02	CXCL10,CYR61,EDN1,EGR1,FKBP5,FOS,GRN,HIF1A,HYOU1,JUN,PFKFB1,TP53	 	
P2	 	A2M	-1.017	transporter	 	0.199	bias	0.425	-0.899	2.43E-02	ATF4,DDIT3,ERN1,GADD45B,HSPA5,SLC40A1,SREBF2	 	
P2	 	ATF1	1.754	transcription regulator	 	-0.469	bias	0.360	-1.261	2.43E-02	EGR1,FOS,FTH1,HLA-G,HMOX1,JUN,THBS1	 	
P2	 	Hbb-b2	 	other	Activated	2.236	bias	0.721	 	2.43E-02	C1QA,CD74,CXCL10,FTH1,FTL,IL10RA,IL2RG	 	
P2	 	PCGEM1	 	other	Activated	2.013	bias	0.536	 	2.43E-02	ALDOA,ENO1,G6PD,GAPDH,PGD,PKM,TALDO1	 	
P2	 	CDK9	1.503	kinase	 	 	 	 	 	2.45E-02	ALAS1,CCND2,FOS,G6PD,HLA-DQA1,HLA-DRA,ODC1,STC2	 	
P2	 	LGALS1	1.466	other	Activated	2.183	bias	0.450	0.942	2.45E-02	CCND2,CXCL16,FIS1,HLA-G,HRAS,LEP,MAF,PTX3	 	
P2	 	ATF3	-2.563	transcription regulator	 	1.161	 	-0.090	1.391	2.52E-02	ADIPOQ,ASNS,BHLHE41,CHAC1,DDIT3,HSPB1,JUN,NUPR1,TNFRSF10B,TP53	 	
P2	 	14,15-epoxyeicosatrienoic acid	 	chemical - endogenous mammalian	 	0.254	 	0.144	-0.027	2.54E-02	ADIPOQ,FGF2,NME1,PIK3CG	 	
P2	 	ACACB	-2.112	enzyme	Inhibited	-2.000	bias	-0.515	 	2.54E-02	LEP,MVD,SCD,SREBF2	 	
P2	 	AQP1	1.031	transporter	 	1.000	 	0.240	0.520	2.54E-02	AKR1B1,CES1,HSPH1,NUPR1	 	
P2	 	CFB	-1.263	peptidase	Activated	2.000	bias	0.631	 	2.54E-02	C3AR1,DDIT3,HSPA5,TGFB2	 	
P2	 	CGB3 (includes others)	-2.373	other	 	 	 	 	 	2.54E-02	DUSP6,ESR2,LHCGR,WNT5B	 	
P2	 	RNASEL	1.325	enzyme	 	 	 	 	 	2.54E-02	ISG15,MT-ATP6,MT-CO2,TP53	 	
P2	 	acadesine	 	chemical drug	 	 	 	 	 	2.54E-02	DUSP4,EGR1,THRSP,TP53	 	
P2	 	cyclopiazonic acid	 	chemical - endogenous non-mammalian	 	0.061	bias	0.450	-0.839	2.54E-02	DDIT3,EGR1,FAS,FOS	 	
P2	 	hydrogen sulfide	 	chemical - endogenous mammalian	 	1.961	bias	0.432	1.113	2.54E-02	DDIT3,HMOX1,HSPA5,TXN	 	
P2	 	mir-103	-3.166	microrna	 	-1.941	bias	-0.721	 	2.54E-02	AIP,GRN,HIF1A,TP53	 	
P2	 	gefitinib	 	chemical drug	 	 	 	 	 	2.56E-02	ADAMTS15,BTG2,CKAP2,COL15A1,COL8A1,CTSA,CTSB,FGFR2,GADD45B,HMOX1,HSPB1,KIT,MAP4K4,MKI67,STAT1,TNFRSF10B,TOP2A,WNT5B	 	
P2	 	SBDS	1.361	other	 	 	 	 	 	2.60E-02	AKR1C1/AKR1C2,AKR1C3,CHAC1,DDIT3,EGR1,FOS,GADD45B,HSPA5,PSMD7,RAC1,SPP1,TRIB3	 	
P2	 	4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone	 	chemical toxicant	 	0.661	bias	0.529	 	2.64E-02	ANXA1,FOS,JUN,LCP1,NFE2L2,SPP1	 	
P2	 	ELF4	1.451	transcription regulator	 	0.686	bias	0.336	-0.122	2.64E-02	KIT,KLF4,LYZ,NDUFS8,SPP1,TP53	 	
P2	 	NRXN1	-1.128	transporter	 	 	 	 	 	2.64E-02	ITGA7,MMRN1,PCDH19,SLC1A3,SOX9,THBS1	 	
P2	 	methylnitrosourea	 	chemical toxicant	 	 	 	 	 	2.64E-02	EGR1,GSTP1,JUN,PSME1,RPS12,SOD1	 	
P2	 	CYR61	-3.873	other	 	0.459	bias	0.587	 	2.65E-02	CCND2,CYR61,DVL1,HIF1A,ITGAV,NR4A1,SFRP1,TIMP1,TP53	 	
P2	 	F2R	1.736	g-protein coupled receptor	 	-1.252	bias	0.668	 	2.65E-02	CYR61,EGR1,FOS,HMOX1,MIF,NR4A1,THBS1,TP53,VCAM1	 	
P2	 	SGK1	-1.292	kinase	 	0.308	bias	0.525	 	2.65E-02	KCNQ4,SCNN1B,SLC1A2,SLC1A3,SLC1A5,SLC38A3,SLC3A2,SLC5A3,STIM1	 	
P2	 	mir-29	 	microrna	 	-0.492	bias	-0.534	 	2.65E-02	ADAM12,AOX1,CLDN1,FKBP5,KIT,PIK3R1,PRKRA,THBS1,TP53	 	
P2	 	MAPK9	1.759	kinase	 	1.758	bias	0.303	0.610	2.72E-02	DMD,EDN1,EGR1,FOS,GADD45B,GAPDH,HIF1A,HMGA1,JUN,MIF,NME2,PLIN2,PTX3,RAC1,RILPL1,RPSA,SCD,TP53	 	
P2	 	CLDN6	-1.007	other	 	 	 	 	 	2.73E-02	ATF4,CLDN1,ERN1,HSPA5,KLF4	 	
P2	 	COMMD1	2.056	transporter	 	-1.000	bias	-0.721	 	2.73E-02	ALDOA,LGALS2,PFKFB3,STAT1,STC2	 	
P2	 	diosgenin	 	chemical - endogenous non-mammalian	 	1.477	 	0.031	1.408	2.73E-02	ABCC3,CYP3A5,EDN1,HMGCS1,SREBF2	 	
P2	 	FYN	1.325	kinase	 	-0.169	 	0.197	-0.667	2.74E-02	CXCL10,FOS,HMOX1,MBP,NFE2L2,NQO1,SOCS3,TP53	 	
P2	 	gemcitabine	 	chemical drug	 	1.698	bias	0.432	0.649	2.74E-02	CYP3A5,FAS,GLB1,HIF1A,HLA-DRA,HMOX1,PEBP1,TP53	 	
P2	 	Laminin	 	complex	 	0.000	 	0.070	-0.138	2.75E-02	APP,ETV5,MAPT,RPSA,SDC4,STMN2,TGFB2	 	
P2	 	MUC1	-1.031	other	 	0.601	bias	0.331	-0.092	2.75E-02	ABCC1,CD83,HIF1A,HLA-DRA,MKI67,PDGFA,SOD1	 	
P2	 	S-nitrosoglutathione	 	chemical toxicant	 	-0.394	 	-0.114	-0.097	2.75E-02	CXCL10,HIF1A,HLA-DRA,NQO1,SOD1,TP53,VCAM1	 	
P2	 	fasudil	 	chemical drug	 	-1.026	bias	-0.320	-0.186	2.75E-02	CD14,JUN,MIF,SLC1A2,SLC1A3,TGFB2,VCAM1	 	
P2	 	5-hydroxytryptamine	 	chemical - endogenous mammalian	 	0.621	bias	0.561	 	2.76E-02	CYBB,EGR1,FGF2,FOS,HIF1A,NR4A1,STAB1,THBS1,UCP2,VCAM1	 	
P2	 	SREBF2	2.182	transcription regulator	 	1.667	bias	0.555	 	2.76E-02	AACS,G6PD,HMGCS1,MSMO1,MVD,PLIN2,PMVK,SCD,SREBF2,THRSP	 	
P2	 	gemfibrozil	 	chemical drug	Activated	2.386	bias	0.324	1.391	2.76E-02	ANXA7,APOE,APP,HADHB,MBP,POR,RTN4,SCD,SOCS3,TPP1	 	
P2	 	NR4A1	-8.304	ligand-dependent nuclear receptor	 	-0.113	 	0.067	-0.331	2.78E-02	ADIPOQ,AKR1C1/AKR1C2,ALDOA,APOB,APOE,CIDEA,COL16A1,DDIT3,G0S2,GYS1,HIF1A,HMOX1,LEP,MAT2A,NR4A2,PEBP1,RAMP3,SCD,UCP2,VCAM1	 	
P2	 	ERG	-1.235	transcription regulator	 	1.069	bias	0.598	 	2.79E-02	ACTN1,APOC1,ARHGEF2,CLIP1,COLGALT1,EPB41L3,FHL1,FKBP5,FLNC,FOSB,HPCAL1,MYO1D,MYO5A,NLGN1,NR4A2,PLEK,RAB7A,SPP1,SREBF2,THBS1,TRIOBP,ZBTB16	 	
P2	 	CNR1	-1.537	g-protein coupled receptor	 	0.785	bias	0.321	-0.443	2.83E-02	ADIPOQ,ADORA1,ALPL,APOE,CXCL10,FGF2,FOS,GLO1,HAGH,HSPA4,KRT6B,LEP,NME2,RAC1,SLC35B2,SOX6,TIMP1	 	
P2	 	Nr1h	 	group	 	1.022	bias	-0.266	2.063	2.83E-02	ACSL3,AGPAT1,APOC1,APOE,CCND2,CXCL10,EDN1,FECH,FGF1,NR5A2,PLA2G2A,PLTP,SCD,SFRP1,THBS1,TP53,ZBTB16	 	
P2	 	4-methylcatechol	 	chemical - endogenous mammalian	 	 	 	 	 	2.90E-02	HMOX1,JUN	 	
P2	 	AKR1C3	2.853	enzyme	 	 	 	 	 	2.90E-02	FKBP4,SIAH2	 	
P2	 	AP2A1	1.090	transporter	 	 	 	 	 	2.90E-02	APP,TALDO1	 	
P2	 	APLP2	1.764	other	 	 	 	 	 	2.90E-02	PRNP,TP53	 	
P2	 	ARID2	1.078	transcription regulator	 	 	 	 	 	2.90E-02	ALPL,FGFR2	 	
P2	 	ATF6B	1.149	transcription regulator	 	 	 	 	 	2.90E-02	DDIT3,HSPA5	 	
P2	 	ATP2A1	-5.459	transporter	 	 	 	 	 	2.90E-02	DDIT3,HSPA5	 	
P2	 	BBS12	-1.238	other	 	 	 	 	 	2.90E-02	ADIPOQ,LEP	 	
P2	 	BO-653	 	chemical drug	 	 	 	 	 	2.90E-02	PSMA3,PSMA4	 	
P2	 	CALCR	-13.973	g-protein coupled receptor	 	 	 	 	 	2.90E-02	FOS,TP53	 	
P2	 	CHRM4	-4.147	g-protein coupled receptor	 	 	 	 	 	2.90E-02	EGR1,ITGAV	 	
P2	 	CYP26B1	-2.337	enzyme	 	 	 	 	 	2.90E-02	ATF5,P2RX7	 	
P2	 	DNM1	-1.519	enzyme	 	 	 	 	 	2.90E-02	APP,SLC24A2	 	
P2	 	ESRP1	-1.080	other	 	 	 	 	 	2.90E-02	FGFR2,RAC1	 	
P2	 	FFAR3	-1.810	g-protein coupled receptor	 	 	 	 	 	2.90E-02	LEP,TP53	 	
P2	 	GCLC	1.385	enzyme	 	 	 	 	 	2.90E-02	FOS,JUN	 	
P2	 	GJB6	15.146	transporter	 	 	 	 	 	2.90E-02	GJB2,MBP	 	
P2	 	GNRH2	-6.793	other	 	 	 	 	 	2.90E-02	RPLP1,RPSA	 	
P2	 	GRM3	-2.814	g-protein coupled receptor	 	 	 	 	 	2.90E-02	SLC1A2,SLC1A3	 	
P2	 	HS6ST2	-10.281	enzyme	 	 	 	 	 	2.90E-02	FGF2,TPSAB1/TPSB2	 	
P2	 	JDP2	1.290	transcription regulator	 	 	 	 	 	2.90E-02	JUN,TP53	 	
P2	 	LETM1	1.763	other	 	 	 	 	 	2.90E-02	MT-CO1,MT-ND6	 	
P2	 	MAF1	1.642	other	 	 	 	 	 	2.90E-02	MT-TY,NNMT	 	
P2	 	MME	-1.217	peptidase	 	 	 	 	 	2.90E-02	APP,SYP	 	
P2	 	NDST2	1.361	enzyme	 	 	 	 	 	2.90E-02	CMA1,CPA3	 	
P2	 	NUDT2	1.014	phosphatase	 	 	 	 	 	2.90E-02	KIT,TPSAB1/TPSB2	 	
P2	 	PDIA3	1.600	peptidase	 	 	 	 	 	2.90E-02	FCGR3A/FCGR3B,PRNP	 	
P2	 	POU2F3	2.071	transcription regulator	 	 	 	 	 	2.90E-02	KRT10,KRT14	 	
P2	 	RNASEH2B	2.425	enzyme	 	 	 	 	 	2.90E-02	ISG15,PHLDA3	 	
P2	 	RRM2	1.027	enzyme	 	 	 	 	 	2.90E-02	HIF1A,THBS1	 	
P2	 	SLC37A4	1.270	transporter	 	 	 	 	 	2.90E-02	DDIT3,HSPA5	 	
P2	 	SSFA2	-1.002	other	 	 	 	 	 	2.90E-02	ADIPOQ,LEP	 	
P2	 	TMSB10/TMSB4X	1.960	other	 	 	 	 	 	2.90E-02	FAS,TMSB10/TMSB4X	 	
P2	 	TRHR	-2.370	g-protein coupled receptor	 	 	 	 	 	2.90E-02	LEP,SOCS3	 	
P2	 	TXN2	1.537	enzyme	 	 	 	 	 	2.90E-02	CYBB,RAC1	 	
P2	 	USE1	-1.074	other	 	 	 	 	 	2.90E-02	DDIT3,HSPA5	 	
P2	 	VLDL	 	complex	 	 	 	 	 	2.90E-02	PLIN2,VCAM1	 	
P2	 	ammonia	 	chemical - endogenous mammalian	 	 	 	 	 	2.90E-02	SLC1A3,SLC7A6	 	
P2	 	bafilomycin	 	chemical - endogenous non-mammalian	 	 	 	 	 	2.90E-02	HIF1A,SQSTM1	 	
P2	 	cloprostenol	 	chemical drug	 	 	 	 	 	2.90E-02	SOCS3,TIMP1	 	
P2	 	durapatite	 	chemical - endogenous mammalian	 	 	 	 	 	2.90E-02	ALPL,SPP1	 	
P2	 	griseofulvin	 	chemical drug	 	 	 	 	 	2.90E-02	ALAS1,HMOX1	 	
P2	 	ibotenic acid	 	chemical toxicant	 	 	 	 	 	2.90E-02	FOS,JUN	 	
P2	 	parbendazole	 	chemical reagent	 	 	 	 	 	2.90E-02	ALPL,SPP1	 	
P2	 	rubitecan	 	chemical drug	 	 	 	 	 	2.90E-02	FAS,PEBP1	 	
P2	 	sGC	 	complex	 	 	 	 	 	2.90E-02	EGR1,FOS	 	
P2	 	succinylacetone	 	chemical - endogenous mammalian	 	 	 	 	 	2.90E-02	ALAS1,CYBB	 	
P2	 	teniposide	 	chemical drug	 	 	 	 	 	2.90E-02	FAS,TP53	 	
P2	 	tyrosine kinase	 	group	 	 	 	 	 	2.90E-02	HMOX1,INSR	 	
P2	 	Sn50 peptide	 	chemical toxicant	Inhibited	-2.359	bias	-0.572	 	2.92E-02	APOE,FAS,HMOX1,MIF,SLC1A2,SLC1A3,TP53,TYMP,VCAM1	 	
P2	 	TFAP2C	1.129	transcription regulator	 	-0.596	 	-0.193	-0.100	2.92E-02	ALCAM,ANLN,FKBP4,HIST1H1C,HK1,MBP,RET,SLC19A1,THBS1	 	
P2	 	MYOD1	-6.765	transcription regulator	 	1.803	bias	0.402	0.120	2.93E-02	ADORA1,ALDOA,ASS1,BIN1,CCND3,CRYAB,DMD,GYS1,HSPB8,ITGA7,KIFC3,MKI67,MSC,PDGFA,PSMB4,RBM38,RPL7A,SH3GLB1,SLC12A2,STAM,TNS1	 	
P2	 	NOS2	-2.522	enzyme	Activated	2.359	 	0.082	2.009	2.93E-02	ADIPOQ,APP,CD14,CD53,CYCS,EDN1,FAS,G6PD,HIF1A,HMOX1,IL1RN,IRAK1,ISG15,LEP,S100A8,SLC1A5,SLC40A1,STXBP1,SYP,TIMP1,TYROBP	 	
P2	 	VCAN	1.572	other	 	-1.479	 	-0.089	-1.127	2.94E-02	APOE,ASS1,CIDEA,CRISPLD2,FAS,GLB1,IGFBP4,IL1RN,MAP1B,MIF,PLA2G2A,PRDX5,PRELP,TIMP1,TP53,VCAM1	 	
P2	 	CYP1A1	-12.709	enzyme	 	 	 	 	 	3.00E-02	ANXA7,BANF1,CBX3,DNAL4,DYNLRB1,GPC1,KIF2A,MAPT,NDUFA1,NQO1,ODC1,SDHB,VAMP8	 	
P2	 	REL	-1.054	transcription regulator	Activated	2.101	bias	0.645	 	3.01E-02	ANLN,APP,BARD1,CAMK2D,CCND2,COPS4,CXCL10,ETV5,FAS,FOS,GADD45B,HLA-A,IRF5,JUN,MAFG,NFE2L2,NR4A1,PPP1R14B,RAP2A,SH2B3,SLC22A15,SLC7A6,SORBS1,TBCA,TNFRSF10B	 	
P2	 	miR-199a-5p (and other miRNAs w/seed CCAGUGU)	 	mature microrna	 	-1.929	bias	-0.700	 	3.02E-02	ALOX5AP,CSTB,HIF1A,ISG15,KLF4,MYL9,TGFBR1,VPS11,WNT5B,ZBTB16	 	
P2	 	IRF9	1.199	transcription regulator	 	 	 	 	 	3.03E-02	CXCL10,GBP1,IRF5,ISG15,SOCS3,STAT1	 	
P2	 	TSC1	-1.010	other	Inhibited	-2.400	 	-0.075	-2.221	3.03E-02	DDIT3,FAM129A,FLNA,HMOX1,STAT1,TP53	 	
P2	 	tempol	 	chemical drug	 	-1.698	bias	-0.360	-0.824	3.03E-02	CYCS,MT-CO1,SPP1,TP53,UCP2,VCAM1	 	
P2	 	BRAF	1.215	kinase	 	0.254	bias	0.336	-0.402	3.05E-02	CSF1R,CXCL10,DUSP4,EGR1,HIF1A,SERPINE2,THBS1,TPO	 	
P2	 	MAF	2.281	transcription regulator	 	1.513	bias	0.475	0.471	3.05E-02	CRYAB,GCLM,MAF,MAFG,NQO1,TP53,TXN,VCAM1	 	
P2	 	8-bromo-cAMP	 	chemical reagent	 	1.424	bias	0.403	-0.256	3.09E-02	ALDH2,APP,CTSD,DUSP4,EGR1,FAM89B,FAS,FGF2,FOS,GSTP1,JUN,LHCGR,MAT2A,NQO1,ODC1,PTGFR,SLC1A2,SPP1,TGFB2,TIMP1	 	
P2	 	D-fructose	 	chemical - endogenous mammalian	 	0.808	bias	0.681	 	3.10E-02	ADIPOQ,CD68,CXCL10,SCD,SLC2A5,THBS1,TIMP1	 	
P2	 	DMP1	-12.955	other	 	-1.134	bias	-0.309	-0.317	3.10E-02	ALPL,BZW2,C1QB,F13A1,FGF1,SPP1,STAB1	 	
P2	 	EFNA4	2.016	kinase	 	-1.134	 	-0.172	-0.680	3.10E-02	DSG1,DUSP4,DUSP6,ETV5,KRT10,S100A7,SOX9	 	
P2	 	MTORC1	 	complex	Activated	2.111	bias	0.515	 	3.10E-02	ATF4,KLF4,MBP,PKM,SCD,SREBF2,UCHL1	 	
P2	 	TYROBP	4.392	transmembrane receptor	 	 	 	 	 	3.10E-02	CD83,NCKAP1L,SH2B3,SLC1A5,SPP1,TREM2,TYROBP	 	
P2	 	advanced glycation end-products	 	chemical - endogenous mammalian	 	1.670	bias	0.360	0.822	3.10E-02	AGER,DDAH2,FGF2,MKI67,PFN1,SPP1,VCAM1	 	
P2	 	FOXA1	-3.110	transcription regulator	 	-0.899	 	0.019	-0.954	3.13E-02	ANXA1,ATP5J,EPHX1,FKBP4,HK1,MYL9,NR4A2,PFKFB1,PRNP,S100A2,SIAH2,SLC12A2,SOD1,SOX9,TCF7,TNFRSF12A	 	
P2	 	7-nitroindazole	 	chemical reagent	 	1.131	bias	-0.288	1.702	3.13E-02	FOS,FOSB,GSTP1,NCAM1	 	
P2	 	ACSL5	-1.253	enzyme	 	-1.000	 	0.042	-1.085	3.13E-02	ANOS1,GALNT13,PEG10,PHLDA2	 	
P2	 	COPS5	-1.115	transcription regulator	 	1.067	 	0.127	0.815	3.13E-02	HIF1A,LHCGR,MARS,TP53	 	
P2	 	Mir122a,b	 	group	 	0.000	 	0.000	0.000	3.13E-02	ADAM17,LAMP1,PRKRA,TP53	 	
P2	 	NCR2	-16.131	transmembrane receptor	 	-0.849	bias	0.721	 	3.13E-02	NR4A1,NR4A2,THBS1,TYROBP	 	
P2	 	S100B	-1.965	other	 	0.000	bias	0.499	-0.988	3.13E-02	AGER,APP,FOS,JUN	 	
P2	 	T	-7.583	transcription regulator	 	1.000	bias	0.721	 	3.13E-02	ALCAM,CD151,SOX6,SOX9	 	
P2	 	calcipotriene	 	chemical drug	 	-0.132	 	0.212	-0.554	3.13E-02	FOS,JUN,KRT10,SPP1	 	
P2	 	cryptotanshinone	 	chemical drug	 	1.212	 	-0.212	1.620	3.13E-02	CD14,DDIT3,TNFRSF10B,TP53	 	
P2	 	metyrapone	 	chemical drug	 	0.132	bias	0.297	-0.457	3.13E-02	ABCC3,ALAS1,CYP3A5,FOS	 	
P2	 	vanadate	 	chemical - other	 	-0.132	 	0.127	-0.385	3.13E-02	INSR,JUN,MSR1,ODC1	 	
P2	 	Akt	 	group	 	0.432	bias	0.312	-0.948	3.15E-02	ATF4,CCND2,CCND3,CIDEA,CTSD,CXCL10,FAS,FOS,HIF1A,HMOX1,INSR,JUN,LEP,LHCGR,MT-CO1,NFE2L2,PEA15,PPP1R1B,PTX3,SLC1A2,SOCS3,SPP1,THBS1,TP53,VCAM1	 	
P2	 	Tgf beta	 	group	 	0.006	bias	0.308	-1.384	3.15E-02	ADAM12,BAMBI,CCND2,CD209,CSF1R,CXCL10,CYR61,DAB2,EDN1,ENG,FGF2,FOS,GADD45B,HMOX1,HNRNPAB,JUN,KDM6B,MAF,MIF,NR4A2,PDGFA,SOCS3,SPP1,TIMP1,VCAM1	 	
P2	 	ANG	-1.919	enzyme	 	 	 	 	 	3.16E-02	CXCL10,CXCL9,TP53	 	
P2	 	APR-246	 	chemical drug	 	 	 	 	 	3.16E-02	GJB6,KRT14,KRTDAP	 	
P2	 	Atrial Natriuretic Peptide	 	group	 	 	 	 	 	3.16E-02	ADIPOQ,EDN1,LEP	 	
P2	 	CMKLR1	2.041	g-protein coupled receptor	 	 	 	 	 	3.16E-02	ADIPOQ,CCND2,PLIN1	 	
P2	 	CNGA3	-22.535	ion channel	 	 	 	 	 	3.16E-02	CAPN2,DDIT3,HSPA5	 	
P2	 	Cux1	 	transcription regulator	 	 	 	 	 	3.16E-02	DAB2,HIST1H4C,HTRA1	 	
P2	 	MXD1	1.808	transcription regulator	 	 	 	 	 	3.16E-02	CCND2,EDN1,ODC1	 	
P2	 	NEIL2	1.223	enzyme	 	 	 	 	 	3.16E-02	GAPDH,MT-CO2,MT-CO3	 	
P2	 	NMNAT1	-1.289	enzyme	 	 	 	 	 	3.16E-02	NPY1R,PEG10,TGFB2	 	
P2	 	PRKRA	2.297	other	 	 	 	 	 	3.16E-02	MAF,RET,THBS1	 	
P2	 	RANBP9	1.453	other	 	 	 	 	 	3.16E-02	FOS,JUN,SYP	 	
P2	 	RNF216	1.223	enzyme	 	 	 	 	 	3.16E-02	CXCL10,ISG15,TRAF3	 	
P2	 	RPS6KA3	1.047	kinase	 	 	 	 	 	3.16E-02	FOS,LEP,TNFRSF10B	 	
P2	 	RV 538	 	chemical reagent	 	 	 	 	 	3.16E-02	ATP13A2,LAMP2,PRNP	 	
P2	 	Shc	 	group	 	 	 	 	 	3.16E-02	CCND2,CCND3,FOS	 	
P2	 	TAPI-1	 	chemical - protease inhibitor	 	 	 	 	 	3.16E-02	APP,MT-CO1,VCAM1	 	
P2	 	acitretin	 	chemical drug	 	 	 	 	 	3.16E-02	APP,ODC1,PI3	 	
P2	 	anacardic acid	 	chemical - endogenous non-mammalian	 	 	 	 	 	3.16E-02	DDIT3,EDN1,HSPA5	 	
P2	 	dydrogesterone	 	chemical drug	 	 	 	 	 	3.16E-02	AKR1C1/AKR1C2,AKR1C3,SRD5A1	 	
P2	 	edaravone	 	chemical drug	 	 	 	 	 	3.16E-02	DDIT3,FAS,HSPA5	 	
P2	 	mesalamine	 	chemical drug	 	 	 	 	 	3.16E-02	HMOX1,ODC1,TPM3	 	
P2	 	streptozocin	 	chemical drug	 	1.114	 	0.118	0.609	3.21E-02	AGER,ALDH3A2,ALPL,CCND3,CYP4A11,FAS,FOS,HIF1A,HMOX1,INSR,KIT,LEP,MSR1,NQO1,NTRK3,OGT,SCD,SLC25A5,SLC2A5,SOD1,SPP1,TGFBR1,VDAC1	 	
P2	 	DTX1	1.109	transcription regulator	 	-0.447	 	0.144	-0.770	3.21E-02	DUSP6,EGR1,SPP1,SPRY4,TGFB2	 	
P2	 	HEXIM1	1.198	transcription regulator	 	-1.287	bias	-0.360	-0.486	3.21E-02	ANXA1,FGF2,HIF1A,TGFB2,TP53	 	
P2	 	alpha-tocopherol	 	chemical drug	 	-0.447	bias	-0.432	0.520	3.21E-02	ADIPOQ,HMOX1,LEP,SQSTM1,TP53	 	
P2	 	clodronic acid	 	chemical drug	 	1.387	bias	0.317	0.683	3.21E-02	CXCL10,FOS,HMOX1,MSR1,VCAM1	 	
P2	 	CRH	-5.635	cytokine	 	-1.774	bias	0.313	-2.632	3.21E-02	EDN1,FOS,IL1RN,KCNMA1,KRT14,LEP,NR4A1,RAMP2,SOCS3	 	
P2	 	LCN2	1.680	transporter	 	1.830	bias	0.408	0.645	3.21E-02	ACTN1,ANLN,ATF5,CAPG,CKAP2,CXCL10,HIF1A,HMOX1,IL1RN	 	
P2	 	NCOA2	1.272	transcription regulator	 	0.771	bias	0.432	-0.432	3.21E-02	ADIPOQ,CXCL10,EGR1,FAM89B,HCAR2,ISG15,NR1D1,PLIN1,RET	 	
P2	 	Sb202190	 	chemical - kinase inhibitor	 	-1.462	bias	-0.489	0.324	3.25E-02	ATP5J2,CCND2,CCND3,CXCL10,EGR1,FGFR2,FOS,HIF1A,HMOX1,HSPA5,PLA2G2A,S100A8,TNFRSF10B,TP53,TYMP	 	
P2	 	SATB1	-1.591	transcription regulator	 	0.667	 	-0.139	1.246	3.25E-02	ACTG1,ACTN1,CTNNA1,CTSD,CYBB,DUSP4,FAM129A,FOSB,GADD45B,GDF15,HSPA8,IL10RA,NFE2L2,NR4A2,PSMD2,RPLP0,RPLP1,TMEM2,WARS	 	
P2	 	EGLN1	1.222	enzyme	 	-1.256	 	-0.103	-0.993	3.38E-02	ADAMTS5,AGER,HIF1A,LEP,PFKL,SDC4,TGFB2,TGFBR1	 	
P2	 	NKX3-1	-1.337	transcription regulator	 	 	 	 	 	3.38E-02	BTG2,CA3,CTSB,FOS,PIK3R1,PTPRC,PTPRK,SDC4	 	
P2	 	enalapril	 	chemical drug	 	1.414	 	0.042	1.294	3.38E-02	ASNS,CAPN6,EFEMP2,SPP1,TIMP1,TNFRSF12A,UCP2,VCAM1	 	
P2	 	platelet activating factor	 	chemical - endogenous mammalian	 	0.670	bias	0.519	 	3.38E-02	EGR1,FGF2,FOS,ITGB2,NR4A1,PAFAH1B2,THBS1,TIMP1	 	
P2	 	NKX2-1	-2.954	transcription regulator	 	-0.283	bias	0.328	-0.931	3.43E-02	AGER,BTG3,CD14,CD74,CYGB,EPHB3,FARSB,HLA-A,HS2ST1,LYZ,MAPT,QSOX1,RET,SCD,SREBF2,SSBP1,TGFB2,THBS1,TPO,WNT5B	 	
P2	 	Ras	 	group	 	-0.435	bias	0.459	-1.824	3.46E-02	ARHGEF2,CCND3,CXCL10,EDN1,EGR1,FOS,GSTP1,HMGA1,HMOX1,JUN,ODC1,PDGFA,SERPINE2,STAT1,TP53	 	
P2	 	TSLP	-1.187	cytokine	 	 	 	 	 	3.46E-02	CD63,CD83,CXCL9,MKI67,NME1,TIMP1	 	
P2	 	EFNA3	1.120	kinase	 	-1.134	 	-0.151	-0.735	3.48E-02	DSG1,DUSP4,DUSP6,ETV5,KRT10,S100A7,SOX9	 	
P2	 	NME1	2.945	kinase	 	 	 	 	 	3.48E-02	CTSD,FBL,ICMT,RAC1,SLBP,TIMP1,TP53	 	
P2	 	STAT5A	-1.565	transcription regulator	 	-1.551	 	0.157	-2.085	3.49E-02	ADIPOQ,AKR1C3,CCND2,CCND3,CD68,DYNLRB1,ERAP2,ESR2,FAS,FCER1G,FOS,FOSB,GYS2,HIST1H1C,KIT,MAF,MAL2,NR4A2,PIP,PPFIBP2,RARRES3,SNTB1,SOCS3,TP53,TPM3,TRAF3,TRIM31,WARS,YWHAG	 	
P2	 	ETS2	1.021	transcription regulator	 	0.647	bias	0.605	 	3.53E-02	CSF1R,FGF1,FOS,HMOX1,JUN,LYZ,MSR1,PCSK6,SPP1	 	
P2	 	sodium chloride	 	chemical - endogenous mammalian	 	1.619	bias	0.577	 	3.53E-02	AKR1B1,CYBB,EDN1,FOS,HIF1A,HMOX1,SLC5A3,SOD1,SPP1	 	
P2	 	CCL5	 	cytokine	 	1.955	bias	0.656	 	3.58E-02	ALCAM,ATF4,CAPN2,CCR1,DUSP6,FOS,HMGA1,SOD1,STAT1,TUBB4B	 	
P2	 	CXCL8	-2.761	cytokine	Activated	2.741	bias	0.284	1.963	3.58E-02	ACKR3,ANXA1,CD74,FAS,ITGB2,MTPN,RAC1,TGFBR1,TNFRSF10B,VCAM1	 	
P2	 	cobalt chloride	 	chemical reagent	 	1.670	bias	0.515	 	3.58E-02	ALDOA,BHLHE41,HIF1A,HMOX1,LEP,PKM,SLC1A3,SLC40A1,TP53,VDAC1	 	
P2	 	LEPR	-1.393	transmembrane receptor	 	-0.698	 	0.155	-1.251	3.61E-02	ADIPOQ,ANXA5,APOB,APOE,CD63,CD68,FOS,FYB,GADD45B,HIST1H2AC,IL1RN,LEP,LGMN,MAP4K4,MBP,SOCS3,SREBF2,TIMP1,UCP2	 	
P2	 	E. coli B5 lipopolysaccharide	 	chemical - endogenous non-mammalian	 	0.774	bias	0.349	-0.998	3.63E-02	ACKR3,ALDH2,CCR1,CD83,CES1,CIDEA,CXCL10,CYBB,CYP3A5,FMO1,FOS,GCLM,HLA-A,HMOX1,IL17RA,MAT2A,PPIA,SEPHS2,SOCS3,SOD1,SPP1,TGFB2,TGFBR1,THBS1,TOLLIP,TPO,UBE2I	 	
P2	 	BCL2L1	1.703	other	 	-0.707	 	0.060	-0.877	3.73E-02	ALOX5AP,CYCS,FAS,NQO1,PTPRC,THBS1,TIMP1,TNFRSF10B	 	
P2	 	CD5	1.059	transmembrane receptor	Activated	2.804	bias	0.527	 	3.73E-02	CD4,CD52,IL2RG,MAPK9,MSMO1,PCK2,STAT1,TLR8	 	
P2	 	CUX1	1.480	transcription regulator	 	 	 	 	 	3.73E-02	ARHGDIB,CYBB,FLNA,HIST1H1B,HIST1H4C,ITGB2,NCAM1,THBS1	 	
P2	 	EOMES	3.147	transcription regulator	 	-0.863	 	0.028	-0.940	3.73E-02	AFAP1,DUSP4,FAT3,MESP1,NHLH1,NXPH4,PREX1,TMEM2	 	
P2	 	FGF10	-1.664	growth factor	Activated	2.630	bias	0.691	 	3.73E-02	AGER,ANXA1,ANXA2,CTSB,LFNG,SCD,SOX9,TMEM123	 	
P2	 	capsaicin	 	chemical drug	Activated	2.607	 	-0.066	2.778	3.73E-02	ABCC3,ATF4,DDIT3,FOS,GDF15,HMOX1,LEP,TGFB2	 	
P2	 	TAF4B	1.428	transcription regulator	 	 	 	 	 	3.75E-02	CCND2,JUN,RET,SPP1,ZBTB16	 	
P2	 	UTP	 	chemical - endogenous mammalian	 	1.229	 	0.240	0.766	3.75E-02	CD14,FLNA,SPP1,THBS1,VCAM1	 	
P2	 	bisindolylmaleimide	 	chemical - kinase inhibitor	 	0.200	bias	-0.554	 	3.75E-02	EGR1,FGF2,FOS,GFPT1,NR4A1	 	
P2	 	EGR2	-1.466	transcription regulator	 	0.880	bias	0.633	 	3.78E-02	ABCC1,ASS1,CSF1R,EGR1,FGF2,FOS,HSPA5,JUN,MBP,NXPH4,PIP,S100A1,SCD,SLC12A2,SLC1A3,SOCS3,ZBTB16	 	
P2	 	PARP1	1.276	enzyme	 	0.856	bias	0.440	-0.544	3.80E-02	CXCL10,FAS,FKBP5,FOS,HMOX1,JUN,MT-CO1,PEG10,STAT1,TNFRSF10B,TP53,VCAM1	 	
P2	 	AXIN1	1.308	other	 	-0.849	bias	-0.450	0.043	3.80E-02	CCND2,CSRNP1,FOS,HRAS	 	
P2	 	IFNW1	-1.663	cytokine	 	 	 	 	 	3.80E-02	CD83,CXCL10,CXCL9,RARRES3	 	
P2	 	IL17R	 	complex	Activated	2.000	bias	0.561	 	3.80E-02	CXCL10,S100A7,S100A8,TIMP1	 	
P2	 	ITGA6	1.064	transmembrane receptor	 	0.000	bias	0.561	 	3.80E-02	CCND2,ITGA7,RPSA,TP53	 	
P2	 	RARRES2	-1.023	transmembrane receptor	Inhibited	-2.000	 	0.080	-2.160	3.80E-02	ADIPOQ,CCND2,LEP,PLIN1	 	
P2	 	W7	 	chemical reagent	 	0.577	bias	-0.551	 	3.80E-02	CD14,CD83,FOS,NR4A1	 	
P2	 	cuprizone	 	chemical toxicant	 	-0.784	bias	0.400	-1.570	3.80E-02	CXCL10,FOS,MBP,SOCS3	 	
P2	 	glycine	 	chemical - endogenous mammalian	 	-1.103	 	0.000	-1.103	3.80E-02	ATF4,FOS,ODC1,PCK2	 	
P2	 	methylphenidate	 	chemical drug	 	-1.961	 	0.240	-2.432	3.80E-02	EGR1,FOS,FOSB,NCAM1	 	
P2	 	SRF	-1.076	transcription regulator	 	-1.261	bias	0.309	-2.467	3.85E-02	APOLD1,CLDN1,CMA1,CPA3,CPM,CSRP2,CTSG,DMD,EGR1,EYA2,FGF1,FHL1,FLNA,FOS,FOSB,G0S2,GLIPR1,JUN,LMCD1,MAP4K4,MAPK10,MCF2L,MYL9,NR4A1,NR4A2,OSCP1,PPIA,RNH1,S100A8,SHOC2,SREBF2,TCF7,TUBB4B	 	
P2	 	FGF21	1.880	growth factor	 	-0.266	bias	0.285	-1.009	3.89E-02	ADIPOQ,CIDEA,DGAT2,EGR1,FGFR2,LEP,ME1	 	
P2	 	quinolinic acid	 	chemical - endogenous mammalian	 	-0.450	 	0.072	-0.636	3.89E-02	EGR1,FOS,FOSB,JUN,NTRK3,RET,TP53	 	
P2	 	HDAC2	1.391	transcription regulator	 	1.387	 	0.033	1.269	3.91E-02	CD4,CYBB,DPT,EGR1,FAS,LHCGR,POLD2,PREX1,RRM2B,SCN2A,SFRP1,SOX9,SQSTM1,STMN2,TP53	 	
P2	 	GAPDH	3.386	enzyme	 	-1.249	bias	-0.297	-0.543	3.93E-02	ENO1,FCER1G,GAPDH,SPP1,STAT1,WARS	 	
P2	 	AR	-1.322	ligand-dependent nuclear receptor	Activated	2.618	bias	0.469	0.052	4.03E-02	AKR1C3,CCDC85B,CKAP4,CLGN,DCTPP1,DEGS1,EDN1,EGR1,EPB41L4B,EPHX1,ERN1,FAM89B,FGFR2,FKBP4,FKBP5,GDF15,GSTP1,HSPA5,HSPH1,KCNJ3,KPNA2,KRT14,LHCGR,MAD2L2,MSMO1,NR5A2,NUPR1,ODC1,PDGFA,PER1,PIP,SEC61B,SLC7A11,SOX9,SRD5A1,STAT1,STK39,TGFB2,THBS1,TNFRSF12A,ZBTB16	 	
P2	 	FOXP3	-6.392	transcription regulator	 	0.114	 	-0.211	0.666	4.07E-02	ANXA1,DUSP4,DUSP6,HLA-A,IL17RA,IRAK1,MAF,MAPK9,MGAT1,NRN1,NTRK3,RRM2B	 	
P2	 	FANCC	-1.359	other	 	 	 	 	 	4.11E-02	GDF15,HSPA4,PCLO,PHLDA2,PTPRC,PTX3,TBC1D9,TP53	 	
P2	 	luteolin	 	chemical - endogenous non-mammalian	 	1.180	bias	-0.515	 	4.11E-02	APOB,CXCL10,FOS,GCLM,HMOX1,JUN,TNFRSF10B,TP53	 	
P2	 	3,5-diiodothyronine	 	chemical - endogenous mammalian	 	 	 	 	 	4.12E-02	AK1,ENO1,GAPDH	 	
P2	 	ABCA4	-1.508	transporter	 	 	 	 	 	4.12E-02	AGER,CXCL10,GLO1	 	
P2	 	DRD1	-3.157	g-protein coupled receptor	 	 	 	 	 	4.12E-02	EGR1,FOS,FOSB	 	
P2	 	ELK3	-1.008	transcription regulator	 	 	 	 	 	4.12E-02	EGR1,FOS,HMOX1	 	
P2	 	EPHB1	-1.888	kinase	 	 	 	 	 	4.12E-02	EGR1,FOS,JUN	 	
P2	 	Integrin	 	complex	 	 	 	 	 	4.12E-02	FOS,JUN,SOCS3	 	
P2	 	LY6E	1.967	other	 	 	 	 	 	4.12E-02	CD14,CD83,HLA-DRA	 	
P2	 	MAPK10	2.474	kinase	 	 	 	 	 	4.12E-02	APP,FOS,JUN	 	
P2	 	ST3-Hel2A-2	 	chemical reagent	 	 	 	 	 	4.12E-02	DDIT3,FOS,NR4A2	 	
P2	 	TAS1R3	-3.753	g-protein coupled receptor	 	 	 	 	 	4.12E-02	SLC1A5,SLC3A2,SLC7A11	 	
P2	 	XRCC5	1.634	enzyme	 	 	 	 	 	4.12E-02	APOE,FKBP5,TP53	 	
P2	 	anti-benzo(a)pyrene-diol-epoxide	 	chemical toxicant	 	 	 	 	 	4.12E-02	GADD45B,JUN,TP53	 	
P2	 	azathioprine	 	chemical drug	 	 	 	 	 	4.12E-02	G3BP2,MAZ,PDGFA	 	
P2	 	coal tar	 	chemical drug	 	 	 	 	 	4.12E-02	GSTP1,HMOX1,NQO1	 	
P2	 	estriol	 	chemical - endogenous mammalian	 	 	 	 	 	4.12E-02	HOXA10,PIK3R1,SDC3	 	
P2	 	ferric ammonium citrate	 	chemical drug	 	 	 	 	 	4.12E-02	FTH1,FTL,HMOX1	 	
P2	 	miR-196a-5p (and other miRNAs w/seed AGGUAGU)	 	mature microrna	 	 	 	 	 	4.12E-02	ANXA1,HOXA7,KRT5	 	
P2	 	mimosine	 	chemical drug	 	 	 	 	 	4.12E-02	HLA-DQA1,HLA-DQB1,TP53	 	
P2	 	salubrinal	 	chemical reagent	 	 	 	 	 	4.12E-02	ATF4,HSPA5,SQSTM1	 	
P2	 	vismodegib	 	chemical drug	 	 	 	 	 	4.12E-02	CXCL9,MKI67,SOX9	 	
P2	 	TNFRSF1A	1.571	transmembrane receptor	 	1.132	bias	0.348	-0.108	4.15E-02	ABCC1,ABCC3,CD68,CD83,CXCL10,CYP3A5,GCLM,JUN,NFE2L2,NQO1,P2RX7,PDGFA,SAA1,SOCS3,VCAM1	 	
P2	 	ADAM10	1.491	peptidase	 	 	 	 	 	4.16E-02	APP,CD74,CRYAB,CXCL16,FOS,IRAK1,PRNP,RAMP2,SCN2A,SOX9,SYP	 	
P2	 	caffeine	 	chemical drug	 	-1.207	 	0.025	-1.272	4.21E-02	EGR1,FAM89B,FOS,FOSB,HIF1A,MT-CO1,NR4A1,THBS1,TP53	 	
P2	 	PLG	-9.882	peptidase	 	0.548	bias	0.700	 	4.22E-02	ADIPOQ,AGER,CYR61,EDN1,GULP1,MCOLN3,MIF,RAB7A,RAC1,VDAC1	 	
P2	 	fenretinide	 	chemical drug	 	0.209	 	0.069	-0.003	4.22E-02	DDIT3,ENAH,HIF1A,JUN,LEP,MKI67,MT-CO3,NFE2L2,STAT1,TNFRSF10B	 	
P2	 	TLR4	1.640	transmembrane receptor	 	0.473	bias	0.534	 	4.32E-02	APP,BAMBI,CCND2,CD14,CERS2,CERS6,CMA1,CXCL10,CYP3A5,CYR61,DAB2,EDN1,FAS,HMOX1,HSPA5,HTRA1,ISG15,LMO4,MIF,MT-ND6,NR4A1,NR4A2,NSMAF,PLEK,RILPL1,SGPL1,SLC7A11,SMPD1,SOCS3,SPP1,STAT1,TREM2,TSPO,VCAM1	 	
P2	 	EFNA5	1.104	kinase	 	-1.134	 	-0.218	-0.557	4.32E-02	DSG1,DUSP4,DUSP6,ETV5,KRT10,S100A7,SOX9	 	
P2	 	RBM5	1.057	other	 	-0.547	bias	-0.272	0.160	4.32E-02	ANXA1,ATP6V0C,BTG2,GBE1,ISG15,UBA1,UCP2	 	
P2	 	KEAP1	2.101	transcription regulator	 	-1.446	 	0.060	-1.578	4.33E-02	GSTP1,HMOX1,NFE2L2,NQO1,VCAM1	 	
P2	 	Raf	 	group	 	-1.067	bias	0.407	-1.875	4.33E-02	EDN1,FOS,JUN,TOP2A,TPO	 	
P2	 	WR 1065	 	chemical drug	Activated	2.200	bias	0.667	 	4.33E-02	FAS,GDF15,NME1,TNFRSF10B,TP53	 	
P2	 	ceramide	 	chemical - endogenous mammalian	 	-1.982	 	0.240	-2.459	4.33E-02	FOS,GAPDH,JUN,SFRP1,TP53	 	
P2	 	dithiothreitol	 	chemical reagent	 	0.646	bias	0.407	-0.242	4.33E-02	DDIT3,HIF1A,HMOX1,HSPA5,SEL1L	 	
P2	 	nilvadipine	 	chemical drug	 	0.447	 	0.027	0.388	4.33E-02	CBR1,CRYAB,FGF2,MAP4K4,SDCBP	 	
P2	 	vinblastine	 	chemical drug	 	1.123	bias	0.601	 	4.33E-02	FOS,HIF1A,HLA-A,IGFBP4,TP53	 	
P2	 	MECP2	1.062	transcription regulator	 	0.532	 	0.048	0.426	4.33E-02	ADAM12,ANXA1,APOE,CAPG,EGR1,FKBP5,GSTP1,HSPA5,IRAK1,MBP,NPY1R,NR4A1,SCN2A,SRPX2	 	
P2	 	dimethyl sulfoxide	 	chemical drug	 	-0.066	bias	0.428	-1.646	4.40E-02	ADAM12,ANXA1,CA3,CCND2,CCND3,CYP3A5,DDIT3,FECH,FOS,HMOX1,ITGB2,JUN,NUPR1,SQSTM1,VCAM1	 	
P2	 	ID2	1.784	transcription regulator	 	-0.277	 	-0.082	0.018	4.43E-02	CCND2,CD83,DUSP10,DUSP4,EEF1D,FCER1G,GADD45B,HIF1A,IL10RA,IL20RB,IRF5,LMO4,MAF,NR4A1,PIK3R1,SOCS3,TOX2,TRAF3,ZBTB16	 	
P2	 	IFNE	-1.164	cytokine	 	1.982	bias	0.633	 	4.43E-02	CD83,CXCL10,CXCL9,RARRES3,SLC7A2,STAT1	 	
P2	 	NR2F1	-3.657	ligand-dependent nuclear receptor	 	 	 	 	 	4.43E-02	ALDH2,EGR1,GDF15,LHCGR,RORB,SLC9A1	 	
P2	 	OGT	1.777	enzyme	 	-0.655	 	0.025	-0.703	4.43E-02	FOS,INSR,JUN,NDUFA6,NDUFA9,NDUFC2	 	
P2	 	PLAUR	-2.027	transmembrane receptor	 	0.663	bias	0.502	 	4.43E-02	CTSB,CYBB,ITGAV,MT-CO1,RAC1,SCN2A	 	
P2	 	Ccl2	 	cytokine	 	1.885	bias	0.309	1.076	4.52E-02	ADIPOQ,CD14,CTSB,CXCL10,KLF4,LEP,SDC4,VCAM1	 	
P2	 	IFNA1/IFNA13	-2.148	cytokine	Activated	2.573	bias	0.454	1.405	4.52E-02	CD83,CXCL10,CXCL9,ISG15,RARRES3,SIGLEC1,STAT1,UBE2E1	 	
P2	 	PLAG1	2.000	transcription regulator	 	1.600	bias	0.485	0.242	4.52E-02	ATF5,CLTB,FLNC,NPTXR,PIR,QSOX1,S100A2,TPSAB1/TPSB2	 	
P2	 	alefacept	 	biologic drug	 	-0.563	bias	-0.694	 	4.52E-02	AKR1C3,CD2,CD52,CXCL9,FCGR3A/FCGR3B,NCAM1,SOCS3,STAT1	 	
P2	 	7-ketocholesterol	 	chemical - endogenous mammalian	 	1.000	 	0.114	0.772	4.54E-02	DDIT3,EGR1,HSPA5,TP53	 	
P2	 	CBX7	-1.166	other	Inhibited	-2.000	bias	-0.645	 	4.54E-02	CBX4,CLDN1,CTSS,GDF15	 	
P2	 	CCNE1	-1.283	transcription regulator	 	 	 	 	 	4.54E-02	BARD1,CAPN2,HIF1A,TP53	 	
P2	 	CYP27A1	1.890	enzyme	 	0.254	bias	-0.341	0.920	4.54E-02	APOE,CYP3A5,HMGCS1,SREBF2	 	
P2	 	DAG1	1.556	transmembrane receptor	 	0.000	bias	0.515	 	4.54E-02	DMD,ITGA7,SGCG,SNTA1	 	
P2	 	DPP-23	 	chemical reagent	 	1.982	bias	0.721	 	4.54E-02	ATF4,DDIT3,ERN1,HSPA5	 	
P2	 	HOXA13	-4.493	transcription regulator	 	 	 	 	 	4.54E-02	ENO1,SLC1A2,SOX9,VAPA	 	
P2	 	MNT	2.256	transcription regulator	 	 	 	 	 	4.54E-02	CCND2,DDIT3,GADD45B,ODC1	 	
P2	 	NOS1	-4.282	enzyme	 	-1.165	bias	0.417	-1.983	4.54E-02	ADIPOQ,EGR1,FOS,HIF1A	 	
P2	 	PRKDC	1.480	kinase	 	 	 	 	 	4.54E-02	APOE,FKBP5,NR1D1,PIM3	 	
P2	 	SP100	-1.206	transcription regulator	 	 	 	 	 	4.54E-02	CD14,HSPA8,HSPB8,SRD5A1	 	
P2	 	dipyridamole	 	chemical drug	 	 	 	 	 	4.54E-02	HMOX1,SPP1,TIMP1,TP53	 	
P2	 	isoprenaline	 	chemical drug	 	-1.964	 	0.240	-2.436	4.54E-02	FOS,NR4A1,NR4A2,PER1	 	
P2	 	ketamine	 	chemical drug	 	 	 	 	 	4.54E-02	FOS,HK1,HMOX1,NQO1	 	
P2	 	miR-7a-5p (and other miRNAs w/seed GGAAGAC)	 	mature microrna	 	-0.845	bias	-0.721	 	4.54E-02	FOS,MKNK2,SEPT3,SLC3A2	 	
P2	 	riboflavin	 	chemical - endogenous mammalian	 	1.000	 	0.038	0.924	4.54E-02	CSNK1A1,JUN,SFRP1,TIMP1	 	
P2	 	GNA12	1.963	enzyme	 	-0.923	bias	0.450	-2.264	4.56E-02	ARPC5,CFL2,FOS,G6PD,GCLM,GSTP1,PDGFA,PIK3R1,PPP1CA,TXNRD1	 	
P2	 	JUND	-1.555	transcription regulator	 	0.391	bias	0.336	-0.354	4.58E-02	ALAS1,CSTA,CYBB,FTH1,HMOX1,LHCGR,NR4A1,SPP1,TIMP1	 	
P2	 	NEUROG1	-5.127	transcription regulator	 	-0.707	 	-0.149	-0.286	4.58E-02	ASS1,CCND2,CFH,DCX,LCP1,MFAP4,NEO1,P4HA2,THBS1	 	
P2	 	4-aminophenol	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	GCLM,SPP1	 	
P2	 	ADRA1	 	group	 	 	 	 	 	4.59E-02	EGR1,FOS	 	
P2	 	AGTRAP	1.743	g-protein coupled receptor	 	 	 	 	 	4.59E-02	FOS,HMOX1	 	
P2	 	APAF1	-1.015	other	 	 	 	 	 	4.59E-02	DDIT3,HSPA5	 	
P2	 	AR-A014418	 	chemical reagent	 	 	 	 	 	4.59E-02	GDF15,MAPT	 	
P2	 	ARHGEF25	1.547	other	 	 	 	 	 	4.59E-02	JUN,RAC1	 	
P2	 	CEBPZ	1.366	transcription regulator	 	 	 	 	 	4.59E-02	HSPA7,TOP2A	 	
P2	 	CF102	 	chemical drug	 	 	 	 	 	4.59E-02	CYBB,HIF1A	 	
P2	 	DRD3	-1.323	g-protein coupled receptor	 	 	 	 	 	4.59E-02	FOS,LEP	 	
P2	 	ELAVL4	-1.041	other	 	 	 	 	 	4.59E-02	MAPT,NRN1	 	
P2	 	ERN2	-1.943	kinase	 	 	 	 	 	4.59E-02	DDIT3,HSPA5	 	
P2	 	F2RL3	-2.853	g-protein coupled receptor	 	 	 	 	 	4.59E-02	EGR1,FOS	 	
P2	 	G6PC	-1.420	phosphatase	 	 	 	 	 	4.59E-02	HSPA5,HYOU1	 	
P2	 	Gpcr	 	group	 	 	 	 	 	4.59E-02	FOS,JUN	 	
P2	 	ILF3	1.409	transcription regulator	 	 	 	 	 	4.59E-02	FOS,HLA-DRA	 	
P2	 	Ifna4	 	other	 	 	 	 	 	4.59E-02	ISG15,TP53	 	
P2	 	IgG2b	 	complex	 	 	 	 	 	4.59E-02	APP,MAPT	 	
P2	 	KIDINS220	1.301	transcription regulator	 	 	 	 	 	4.59E-02	EGR1,FOS	 	
P2	 	LY379196	 	chemical - kinase inhibitor	 	 	 	 	 	4.59E-02	EGR1,MSR1	 	
P2	 	MC3R	1.801	g-protein coupled receptor	 	 	 	 	 	4.59E-02	HMOX1,LEP	 	
P2	 	NCK2	1.769	kinase	 	 	 	 	 	4.59E-02	ATF4,DDIT3	 	
P2	 	NUBPL	1.105	other	 	 	 	 	 	4.59E-02	NDUFA13,NDUFS3	 	
P2	 	PLIN2	4.490	other	 	 	 	 	 	4.59E-02	LEP,UCP2	 	
P2	 	RASSF6	-2.664	other	 	 	 	 	 	4.59E-02	BTG2,TP53	 	
P2	 	RFXANK	1.774	transcription regulator	 	 	 	 	 	4.59E-02	HLA-A,HLA-DRA	 	
P2	 	SEMA3F	1.297	other	 	 	 	 	 	4.59E-02	HIF1A,TP53	 	
P2	 	SPRY4	1.988	other	 	 	 	 	 	4.59E-02	ETV5,ISG15	 	
P2	 	TAF9	 	transcription regulator	 	 	 	 	 	4.59E-02	HLA-DRA,TP53	 	
P2	 	TCL1A	3.628	transcription regulator	 	 	 	 	 	4.59E-02	FOS,IL17RA	 	
P2	 	TXNRD1	2.817	enzyme	 	 	 	 	 	4.59E-02	FAS,TP53	 	
P2	 	TYMS	1.700	enzyme	 	 	 	 	 	4.59E-02	FAS,TP53	 	
P2	 	WFS1	1.595	enzyme	 	 	 	 	 	4.59E-02	DDIT3,HSPA5	 	
P2	 	XPC	1.061	other	 	 	 	 	 	4.59E-02	MBP,TP53	 	
P2	 	YY2	-2.372	other	 	 	 	 	 	4.59E-02	FOS,TP53	 	
P2	 	butylated hydroxytoluene	 	chemical toxicant	 	 	 	 	 	4.59E-02	FOS,JUN	 	
P2	 	catechol	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	FOS,JUN	 	
P2	 	ceftriaxone	 	chemical drug	 	 	 	 	 	4.59E-02	SLC1A2,SLC1A3	 	
P2	 	chlorambucil	 	chemical drug	 	 	 	 	 	4.59E-02	FAS,TNFRSF10B	 	
P2	 	cimetidine	 	chemical drug	 	 	 	 	 	4.59E-02	FAS,GDF15	 	
P2	 	dacarbazine	 	chemical drug	 	 	 	 	 	4.59E-02	CXCL10,CXCL9	 	
P2	 	elocalcitol	 	chemical drug	 	 	 	 	 	4.59E-02	SPP1,TGFB2	 	
P2	 	ethacrynic acid	 	chemical drug	 	 	 	 	 	4.59E-02	AKR1C1/AKR1C2,HMOX1	 	
P2	 	fenoldopam	 	chemical drug	 	 	 	 	 	4.59E-02	CYBB,RAC1	 	
P2	 	ferric chloride	 	chemical toxicant	 	 	 	 	 	4.59E-02	FTH1,FTL	 	
P2	 	floxuridine	 	chemical drug	 	 	 	 	 	4.59E-02	TP53,UNG	 	
P2	 	globotriaosylceramide	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	FGF2,LAMP2	 	
P2	 	GTP	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	CD63,GNL3	 	
P2	 	heparan sulfate	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	FGF2,PRNP	 	
P2	 	pyrophosphate	 	chemical - endogenous mammalian	 	 	 	 	 	4.59E-02	ALPL,SPP1	 	
P2	 	quisqualic acid	 	chemical - endogenous non-mammalian	 	 	 	 	 	4.59E-02	EGR1,FOS	 	
P2	 	ruboxistaurin	 	chemical drug	 	 	 	 	 	4.59E-02	CYBB,EGR1	 	
P2	 	ZFHX3	-1.358	transcription regulator	 	 	 	 	 	4.81E-02	GSTP1,HLA-A,HRAS,MIF,POLR2I,RORB,RPL37,RPS12,SIM1,TUBA1B,UQCR10	 	
P2	 	MAP2K4	1.451	kinase	 	0.393	bias	0.632	 	4.95E-02	CXCL10,FLNA,FOS,JUN,KIF2A,MAPK9,TP53,TUBB2A	 	
P2	 	PDGFB	1.869	growth factor	 	-0.095	bias	0.367	-1.108	4.95E-02	EGR1,FGF1,FOS,IL1RN,NR4A1,SPP1,THBS1,TIMP1	 	
P2	 	PRKCB	1.306	kinase	 	0.208	bias	0.445	-0.948	4.95E-02	APP,CD83,CLCN7,CYCS,EGR1,FGF2,FOS,JUN	 	
P2	 	CIDEC	-1.163	other	 	-0.555	bias	-0.669	 	4.97E-02	CIDEA,CYCS,DGAT2,LEP,PLIN1	 	
P2	 	RASSF5	 	other	 	0.447	 	0.154	0.102	4.97E-02	BTG3,DTYMK,RAB32,RPS15,UQCR11	 	
P2	 	ZEB2	1.291	transcription regulator	 	1.400	 	-0.066	1.544	4.97E-02	ALPL,FCER1A,GAB2,MS4A2,SFRP1	 	
P2	 	crocidolite asbestos	 	chemical toxicant	 	-0.308	bias	0.721	 	4.97E-02	BCAT1,FOS,GCLM,JUN,SPP1	 	
P2	 	titanium dioxide	 	chemical drug	 	1.432	bias	0.257	0.862	4.97E-02	ALOX5AP,CRYAB,FAS,HCAR2,LHCGR	 	
P2	 	GDNF	-8.430	growth factor	 	-0.710	bias	0.313	-1.459	4.98E-02	CTSB,EGR1,FOSB,GNB1,GZF1,KIT,NRN1,PPP1R1B,RPSA	 	
P2	 	cytarabine	 	chemical drug	Activated	2.911	bias	0.579	 	4.98E-02	FAS,GAPDH,HLA-A,PPP1CA,SESN2,TGFB2,TNFRSF10B,TOP2A,TP53	 	
P2	 	EGR3	-1.621	transcription regulator	 	-0.128	 	0.062	-0.278	4.98E-02	IRAK1,JUN,PLXND1,RET,SOCS3,SOX9	 	
P2	 	S100A4	1.181	other	 	1.406	bias	0.384	0.565	4.98E-02	AGER,THBS1,TIMP1,TP53,TPO,VCAM1	 	
P2	 	lovastatin	 	chemical drug	 	1.828	 	0.192	1.261	5.18E-02	ADIPOQ,APOE,ATF4,CCND3,DDIT3,HMGCS1,HMOX1,LEP,MKI67,MVD,PIK3R3,PMVK,SDC4,SREBF2	 	
P2	 	celecoxib	 	chemical drug	Activated	2.145	 	-0.174	2.734	5.81E-02	APP,ATF4,CD68,CIDEA,DDIT3,FAS,GDF15,HMOX1,HSPA5,MKI67,SLC25A6,TNFRSF10B,TP53,VCAM1	 	
P2	 	ANXA2	1.670	other	Inhibited	-2.169	 	-0.025	-2.115	6.40E-02	FAS,JUN,SESN2,TNFRSF10B,TP53	 	
P2	 	HOXC8	-3.307	transcription regulator	Inhibited	-2.219	 	0.000	-2.219	7.19E-02	APP,ASS1,CXCL10,NQO1,SPP1	 	
P2	 	semaxinib	 	chemical drug	 	-1.982	 	-0.240	-1.506	7.19E-02	FHL1,HIF1A,HMOX1,NFE2L2,THBS1	 	
P2	 	prostaglandin A1	 	chemical - endogenous non-mammalian	 	1.969	 	0.240	1.496	7.22E-02	CD14,HMOX1,HSPA4,TP53	 	
P2	 	risperidone	 	chemical drug	 	-1.941	 	0.144	-2.221	7.22E-02	CXCL10,FOS,NR4A1,NR4A2	 	
P2	 	CIITA	-1.116	transcription regulator	Activated	2.216	 	0.180	1.817	1.09E-01	CD74,HLA-A,HLA-DQA1,HLA-DQB1,HLA-DRA	 	
P2	 	berberine	 	chemical drug	 	1.755	 	-0.173	2.227	1.19E-01	ADIPOQ,CYP3A5,CYP4A11,HIF1A,HMOX1,INSR,PIK3R3,TIMP1,TP53,UCP2,VCAM1	 	
P2	 	SIAH2	3.033	transcription regulator	 	1.992	 	0.197	1.600	1.44E-01	AKR1C3,FGF1,HIF1A,SIAH2	 	
P2	 	TFAP4	-2.057	transcription regulator	Inhibited	-2.236	 	0.019	-2.280	1.53E-01	CLDN1,EGR1,FOS,GDF15,STEAP3	 	
P2	 	dehydroisoandrosterone	 	chemical - endogenous mammalian	Inhibited	-2.213	 	-0.144	-1.894	1.62E-01	AGER,CYP3A5,CYP4A11,FKBP5,POR,SCD,TP53,VCAM1	 	
P2	 	fluoxetine	 	chemical drug	Inhibited	-2.400	 	0.240	-3.060	1.89E-01	EGR1,FGF2,FOS,FOSB,NME1,NME2,PPP1R1B,SLC1A2	 	
P2	 	3,3'-diindolylmethane	 	chemical drug	Activated	2.449	 	0.060	2.302	2.00E-01	FAS,GDF15,HLA-A,HMOX1,NQO1,TNFRSF10B	 	
P2	 	sodium orthovanadate	 	chemical reagent	 	1.945	 	0.225	1.507	2.03E-01	HIF1A,MSR1,SLC2A5,TP53	 	
P2	 	TNFRSF9	-1.315	transmembrane receptor	Inhibited	-2.000	 	0.042	-2.085	2.51E-01	CD28,FAS,HLA-DQB1,PTPRC	 	
P2	 	TRH	-20.057	other	 	-1.940	 	0.227	-2.380	2.67E-01	FOS,JUN,KRT6B,NR4A1	 	
P2	 	cholic acid	 	chemical - endogenous mammalian	 	1.892	 	0.144	1.529	3.07E-01	ABCC3,CBR1,CYP3A5,CYP4A11,EPHX1,PLTP,SREBF2	 	
P2	 	BNIP3L	-1.336	other	Inhibited	-2.219	 	-0.187	-1.804	3.74E-01	CCND3,CKAP2,EIF2AK1,SFRP1,TOP2A	 	
P2	 	FOSL1	-1.436	transcription regulator	Activated	2.177	 	0.051	2.065	4.04E-01	EGR1,FOS,FOSB,JUN,LHCGR,SERPINE2	 	
P2	 	SCD	2.822	enzyme	 	-1.956	 	-0.187	-1.590	4.19E-01	CXCL10,DDIT3,HSPA5,LEP,UCP2	 	
P2	 	FOXA2	-4.589	transcription regulator	 	1.960	 	0.120	1.724	4.35E-01	ABCA3,ALAS1,APOB,EPHX1,LYZ,MAP1B,MYL9,NR4A2,NR5A2,PKM,SAA1,SCD,TCF7,UCP2	 	
P2	 	TOB1	-1.046	transcription regulator	Inhibited	-2.000	 	-0.125	-1.749	4.36E-01	PHLDA3,TP53,TP53RK,UBA6	 	
P2	 	VIP	1.107	other	Inhibited	-2.075	 	-0.059	-1.912	5.04E-01	CCND3,CXCL10,FOS,IRAK1,LYZ,SLC1A2,SLC1A3,TLR8	 	
P2	 	STK11	1.575	kinase	 	-1.941	 	-0.055	-1.768	1.00E00	ALCAM,FGFR2,GADD45B,HIF1A,MRPS15,NR1D1,PPP1R2,RAB10,TARS,TOP2A	 	

Causal Networks for My Projects->David Bulger->P2

Diseases and Bio Functions for My Projects->David Bulger->P2
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Cellular Growth and Proliferation	proliferation	proliferation of cells	1.50E-27	Increased	5.526	 	1.735	TGFBR1,AGER,PIK3R1,SPRY4,GNB1,POR,CCND3,EIF3B,ATG9A,GLB1,AJUBA,PLXNB2,AIF1,RBM38,YWHAG,NKIRAS2,LAIR1,SURF1,ANXA2,MYL9,NPR3,PSMA4,CTSB,ALCAM,ELMO2,ACTG1,FTH1,BANK1,PIM3,FHL1,GADD45B,DDIT3,GBP1,DAPK2,ADIPOQ,PPIA,RPL26,SYNM,RABL6,AMOT,UCP2,FCGR2A,TUBB4B,IGKC,ENG,IPO7,MAZ,NR4A1,WBP2,SOX9,DCX,PRKACB,SOCS3,AKR1C3,SEPT9,EML4,CCT2,CSNK1A1,FCER1A,DIRAS1,CTSD,HS6ST1,HSF4,STC2,CCT5,MT-ND2,ADAMTS5,GAS5,STK39,RIMS4,BAMBI,PFDN5,CREG1,FYB,TXNRD1,PIK3R3,AES,RBX1,INSR,NDUFS3,UBE2I,HSPB1,ETV5,PEBP1,SCD,SUMO3,IGFBP4,LITAF,BARD1,HDGF,HLA-G,EDN1,STAT1,THBS4,PREB,MT-ATP6,AKR1C1/AKR1C2,USMG5,DVL1,G6PD,SOD1,TSN,RBCK1,FECH,SLC25A5,EFEMP2,MAP4K4,RAN,DDX20,HLA-DQB1,MKI67,GSS,EEF1D,SNX12,ZBTB7B,SGPL1,AHSA1,MGAT4B,AFAP1,ZBTB16,TESK1,SFRP4,CAPN6,HMGA1,NINJ1,MNT,SSBP1,RTN4,B3GNT5,GSTP1,BTG3,SLC1A3,FKBP1A,GPC4,ASNS,H2AFZ,ENAH,MAFG,LYZ,JUN,TXNL1,FKBP5,ACVR1C,GJB2,WSB1,PLXNA1,SIGLEC1,CD209,PTPRK,EGR1,TRIM28,COPS3,STS,HIST1H1B,CALM1 (includes others),CCDC85B,SOX6,RNF144A,SBF1,TREM2,USP22,CDC14B,RNF187,NCAM1,PER1,PLCB2,SLC31A1,PFN1,KCND3,UBE2A,ARF1,CD4,MAP1B,UNC5B,LHCGR,CD63,CAMK2D,SLC25A6,PLCE1,COMT,CHST11,ANXA7,GPC1,C1QBP,RET,TBC1D10C,HK1,PRKRA,GSDMB,GNG2,RAC1,RASD1,TPSAB1/TPSB2,CMC2,ZFAND3,SH2B3,MAPT,RARRES3,CD14,CLCN7,RPS15A,EIF5A,SRM,COPS4,SPRED1,SDHB,ATF5,CD83,DTYMK,RPS4X,NELFE,HINT1,PPP1R9B,THBS1,DUSP10,OAZ1,CYGB,SOX18,MAPKAPK2,ADAMTS15,DAP,VSIG4,KIFAP3,IL20RB,EDF1,KIF2A,TMEM2,PAG1,EPHB3,SLC1A2,VAMP8,NCKAP1L,CPEB1,HLTF,PPP2R1B,UBE2D3,CRYAB,WHSC1,CTSG,COL8A1,CXCL9,SLC9A1,CLIP1,ODC1,FADS3,PTPRC,ARID3B,KEAP1,ST6GALNAC2,ATF4,SCPEP1,STAM,LMX1A,MYBBP1A,HIST1H2AC,TMSB10/TMSB4X,MGAT1,TP53,LCP1,RHEB,DPT,MTSS1,PPP1R1B,PAQR3,TSPYL5,TNFRSF10B,MAD2L2,FGFR2,TPM3,FLOT1,BRF2,ARHGDIB,HAX1,HSPA8,TMEM127,BTG2,GAPDH,DUSP4,AARS,SQSTM1,ESR2,STEAP3,APOE,NME1,GJB6,NACC2,FGF2,PHLDA2,OSGIN1,GDF15,HSPB8,HLA-DQA1,EEF1B2,LGALS9,COPS8,ATRAID,CD74,GLIPR1,LAMP3,C1QTNF9,OGT,TMEFF1,PTPRJ,TNXB,PLIN2,DAB2,ASPH,BCAP31,ADORA1,NFE2L2,KRT10,FCGR3A/FCGR3B,P4HA2,CCR1,S100A1,SRA1,GNA12,SLC39A6,ALOX5AP,LZTS2,TRIB3,SNCG,ISG15,GRN,MRAP,FOS,MYOC,NR4A2,NTRK3,PPT1,MBD3,PSAP,ARHGDIA,BMPER,ABCC3,PPIL1,ADRA1A,ABCB6,ICMT,TRAF3,NCDN,USP5,SCAMP2,MBP,NME2,NRN1,OGFOD1,SLC35F6,CES2,HSPA5,BIN1,NNMT,CD28,HSPA4,ZNRF3,SAE1,RHOG,CYP3A5,ENTPD5,CXCL14,HOXA10,NUPR1,HOXA7,PPP1CA,CHMP1A,CBR1,TOP3B,PFKFB3,IL2RG,PTPRQ,PCSK6,MFSD14A,HNRNPAB,POLR2K,UBA6,CITED1,KLF4,SLC3A2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,CAPN2,PIK3AP1,CST6,CCPG1,MEGF8,HTRA1,SIRPA,INO80B,RPSA,CD151,DOK5,PTGFR,MSR1,MECR,IL17RA,PDGFC,HNRNPK,IRAK1,RAP1GDS1,TIMP1,SAA1,LOC102724428/SIK1,RNH1,RHOBTB2,STOX1,CIZ1,MCRS1,LONP1,KRT14,VCAM1,MT-ND6,SLC9A3R1,NPY1R,SLC12A2,NQO1,EMD,PDLIM4,GIT1,CISD2,AIFM2,ATIC,DEGS1,FGF1,SERPINE2,CXCL16,SHB,CISD1,CAPNS1,PSMD2,EIF3I,TBC1D7,APOB,ITSN1,MAF,HRAS,NCSTN,CXCL10,BCAT1,PEG10,CTSS,ABCC1,PIK3CG,HADHB,TXN,APEX2,WNT5B,HNRNPA0,RIMS3,CFL1,TUBB2A,CTPS1,C9orf69,ANGPTL1,MTPN,CCND2,NR1D1,YARS,PIP5K1C,PSMB2,MS4A4A,STIP1,ORC5,IL10RA,ALDOA,GLUL,SFRP1,TCF7,CYR61,ITGA7,C3AR1,LCP2,S100A11,ATP5G1,ADAM17,LAPTM5,RPS3A,PSMB10,DUSP6,CTNNA1,FOLR2,TAX1BP3,S100A7,PIP,UCHL1,CA3,SEC61A1,SRGAP1,HLCS,TOP2A,SLC19A1,STIM1,NACC1,TPO,NDUFAB1,AMFR,PI4KA,NDUFS4,RPS19,TYROBP,POMGNT1,APP,FIS1,MCF2L,ITGB2,FTL,SUPV3L1,ADCY1,FCER1G,PEA15,FKBP4,PRMT5,TSPO,NR5A2,DVL3,CBX4,GABARAP,DNPH1,SCAMP3,MVD,HOXB5,GAB2,SLC7A11,CCNI,CMA1,SDC4,TUBB,UBA2,CTBP1,PGD,G0S2,ITGAV,IFI30,CYBB,NEO1,SLC7A5,KPNA2,CLCN3,EIF2AK1,PTX3,MIF,SPP1,GPS2,PSMC4,PKN1,SEL1L,EFS,ADCYAP1R1,ACKR3,IL1RN,MAPK10,GNL3,VDAC1,AKR1B1,JTB,CNBP,UBE2J2,LEP,STMN2,EPB41L3,CD2,NLGN1,PDGFA,ERN1,VAPA,PKM,SMPD1,HIF1A,NAA10,FAS,TNFRSF12A,HMOX1,SLFN5,PARK7,PCK2,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,ARHGEF2,NSMF,SELENOH,S100A8,NR2F6,ACTN1,NLRC4,PRNP,NDUFAF3,NACA,COX17,TAF6,CD160,VANGL1,QSOX1,MAPK9,MKNK2,CSF1R,NDUFA13,KCNQ4,TRPM6,ENO1,WARS,OVCA2,CLDN1,UBA1,P2RX7,SHMT2,CARM1	612	
Cell Death and Survival	cell death	cell death	3.42E-25	Decreased	-4.765	 	-2.698	TGFBR1,AGER,ASS1,PIK3R1,VAC14,C1QA,NPAS2,POR,CCND3,EIF3B,AIF1,FBL,YWHAG,LAIR1,SURF1,ANXA2,IRF5,PSMA4,CTSB,ALCAM,PLTP,FTH1,EPHX1,PIM3,GADD45B,DDIT3,PSMD7,DAPK2,ADIPOQ,PPIA,RABL6,AAK1,GNG5,AMOT,TMEM123,UCP2,FCGR2A,IGKC,ENG,CSTB,RPS16,NR4A1,RPL37,SOX9,STK31,SOCS3,YWHAH,AKR1C3,CCT2,CSNK1A1,FCER1A,INTS1,CTSD,AK1,CCT5,MTMR2,NSMAF,STXBP1,GAS5,ASNA1,PFDN5,RPL37A,TXNRD1,AES,RBX1,NAGLU,INSR,UBE2I,HSPB1,ETV5,PEBP1,IGFBP4,SCD,F2RL3,NELFB,DNASE1L3,BARD1,RPL7A,HDGF,HLA-G,ALDH2,EDN1,ISCU,CFH,STAT1,THBS4,DVL1,G6PD,CSRNP1,SOD1,RPS29,RBCK1,SLC25A5,MAP4K4,RPLP0,GFPT1,RAN,DDX20,MKI67,GSS,GLO1,EEF1D,MIEN1,SGPL1,AHSA1,LGMN,AFAP1,NAPA,ZBTB16,SFT2D2,SFRP4,CAPN6,CKAP2,HMGA1,BCAP29,NINJ1,MNT,DPH2,PRELID1,RTN4,ARHGAP35,GSTP1,BTG3,HLA-A,HYOU1,SLC1A3,FKBP1A,ASNS,ATP6AP1,MAFG,LYZ,CES1,JUN,TUB,RPS5,FKBP5,RPL31,ACVR1C,GJB2,RPS24,CD53,WSB1,SYNGR2,TRIM28,EGR1,PLA2G2A,AIP,PI3,CALM1 (includes others),GLIS2,SOX6,USP22,NCAM1,PNO1,PER1,SLC31A1,PFN1,KCND3,CD4,MAP1B,UNC5B,LHCGR,CAMK2D,SLC25A6,PLCE1,COMT,RPL19,CHST11,ANXA7,GPC1,C1QBP,RET,BCKDK,LANCL1,HK1,PRKRA,PSMA6,ACP2,GNG2,HSPA9,PHB2,RAC1,RASD1,TPSAB1/TPSB2,MAPT,FMN2,CD14,CLCN7,RPS15A,EIF5A,SDHB,TOLLIP,ATF5,MRPS30,DTYMK,HINT1,PPP1R9B,THBS1,DUSP10,OAZ1,MAPKAPK2,FAM162A,SCN2A,DAP,BHLHE41,HSPH1,PHLDA3,RPS21,KIFAP3,GBE1,SLC1A2,C6,NCKAP1L,CPEB1,HLTF,PPP2R1B,RPL38,CSTA,CRYAB,KDM6B,WHSC1,RRM2B,CTSG,TMBIM6,CXCL9,PANX1,SLC9A1,ODC1,PTPRC,EMG1,GATAD2A,ARID3B,HIGD2A,MCOLN3,KEAP1,SPTB,ATF4,STAM,MYBBP1A,TMSB10/TMSB4X,UNG,TP53,CERS6,RHEB,PPP1R1B,TNFRSF10B,BCL2L14,MAD2L2,TPM3,FGFR2,RHBDD1,CD52,ARHGDIB,HAX1,DSG1,HSPA8,BTG2,GAPDH,DUSP4,AARS,SQSTM1,LYPLA1,ESR2,STEAP3,ARL8B,APOE,NME1,NACC2,FBXO10,SLC4A2,PHLDA2,OSGIN1,FGF2,GDF15,HSPB8,LGALS9,CD74,GLIPR1,C1QTNF9,OGT,UBE2K,DAB2,BCAP31,ADORA1,HCAR2,NFE2L2,KRT10,FCGR3A/FCGR3B,S100A1,SIGMAR1,SRA1,GNA12,SLC39A6,LZTS2,TRIB3,SNCG,HSPA2,CPEB4,ISG15,GRN,FOS,MYOC,NR4A2,NTRK3,PPT1,KRT6A,TPP1,PSAP,ARHGDIA,TSC22D2,ABCC3,ADRA1A,ICMT,DAD1,TRAF3,SESN2,ATP2B1,ABCA3,MBP,NME2,NRN1,OGFOD1,TYMP,RNASE1,HSPA5,BIN1,CEBPG,CERS2,CD28,HSPA4,SAE1,RHOG,RPS13,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,PPP1CA,CBR1,GULP1,PFKFB3,IL2RG,PTPRQ,DMTN,PPP1R11,SDHC,ARSA,CITED1,KLF4,SLC3A2,FOSB,ADAM12,CAPN2,PIK3AP1,HTRA1,TFPT,SIRPA,RPSA,CD151,PTGFR,MSR1,DMD,IL17RA,PDGFC,HNRNPK,IRAK1,RAP1GDS1,CIAPIN1,SLC19A3,TIMP1,PPP1R2,SAA1,ADCK3,LOC102724428/SIK1,RHOBTB2,MCRS1,LONP1,ATP13A2,KRT14,VCAM1,SLC12A2,NQO1,EMD,PDLIM4,CISD2,AIFM2,DEGS1,NFE2L1,FGF1,SERPINE2,CIDEA,GIPR,KIFC3,CAPNS1,LGALS2,PSMD2,EIF3I,APOB,ITSN1,SH3BGRL3,MAF,HRAS,SH3GLB1,NCSTN,APRT,CXCL10,DYNLL1,PEG10,CTSS,ABCC1,PIK3CG,TXN,EYA2,CFL1,STOML2,ANGPTL1,MTPN,CCND2,NR1D1,YARS,PTPA,STIP1,MBD4,IL10RA,ALDOA,SFRP1,TCF7,CYR61,ITGA7,C3AR1,LCP2,S100A11,HIST1H1C,ADAM17,RAB32,RPS3A,PSMB10,UBQLN1,PAM16,DUSP6,CTNNA1,KAZN,PIP,FANCE,UCHL1,CA3,RPL35,ACSM5,IGHG3,GBA,ANXA5,TOP2A,LAMP1,PSMD14,STIM1,NACC1,RPS12,NDUFAB1,AMFR,NDUFS4,MBOAT7,RPS19,ADRM1,LETM1,TYROBP,MT-ND4,AREL1,APP,EIF3G,MCF2L,ITGB2,FIS1,COL5A3,SUPV3L1,LAMP2,SREBF2,FCER1G,PEA15,FKBP4,MS4A2,PRMT5,TSPO,NR5A2,P2RY12,CYCS,CBX4,GABARAP,GAB2,SLC7A11,PFKFB1,CCNI,SDC4,TAF10,TUBB,UBA2,CTBP1,G0S2,ITGAV,CYBB,NEO1,KPNA2,SIAH2,CLCN3,EIF2AK1,MIF,SPP1,GPS2,LMO4,SGCG,PSMC4,PKN1,SEL1L,ADCYAP1R1,ACKR3,IL1RN,MAPK10,GNL3,VDAC1,AKR1B1,PAFAH1B2,DDAH2,LEP,CD2,PRDX5,ERN1,VAPA,PKM,SMPD1,HIF1A,FAS,TNFRSF12A,HMOX1,PARK7,PCK2,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,PSMA3,ARHGEF2,SLC40A1,NSMF,S100A8,STK40,NLRC4,PRNP,TAF6,CD160,MAPK9,F13A1,CSF1R,NDUFA13,KCNQ4,FAU,ENO1,UBA1,MAT2A,P2RX7	562	
Cell Death and Survival	necrosis	necrosis	9.35E-21	Decreased	-3.808	 	-2.459	TGFBR1,AGER,ASS1,PIK3R1,VAC14,C1QA,EIF3B,CCND3,YWHAG,LAIR1,SURF1,ANXA2,IRF5,CTSB,PSMA4,ALCAM,EPHX1,FTH1,PIM3,GADD45B,PSMD7,DDIT3,DAPK2,ADIPOQ,PPIA,RABL6,AAK1,TMEM123,UCP2,ENG,RPS16,NR4A1,RPL37,SOX9,SOCS3,YWHAH,CCT2,FCER1A,CSNK1A1,CTSD,CCT5,NSMAF,STXBP1,GAS5,RPL37A,TXNRD1,RBX1,NAGLU,INSR,HSPB1,UBE2I,PEBP1,IGFBP4,SCD,F2RL3,NELFB,BARD1,RPL7A,HDGF,HLA-G,ALDH2,EDN1,ISCU,CFH,STAT1,THBS4,DVL1,G6PD,SOD1,RPS29,RBCK1,SLC25A5,RPLP0,GFPT1,RAN,MKI67,EEF1D,GLO1,SGPL1,LGMN,AHSA1,AFAP1,NAPA,ZBTB16,SFT2D2,SFRP4,CAPN6,CKAP2,HMGA1,MNT,DPH2,PRELID1,RTN4,GSTP1,BTG3,SLC1A3,HYOU1,FKBP1A,ASNS,LYZ,CES1,JUN,FKBP5,RPS5,RPL31,ACVR1C,GJB2,RPS24,WSB1,SYNGR2,TRIM28,EGR1,AIP,PI3,GLIS2,USP22,NCAM1,PNO1,PER1,PFN1,CD4,UNC5B,MAP1B,PLCE1,SLC25A6,CAMK2D,COMT,RPL19,GPC1,LANCL1,BCKDK,RET,HK1,PRKRA,PSMA6,HSPA9,GNG2,PHB2,RAC1,TPSAB1/TPSB2,RASD1,MAPT,CD14,EIF5A,RPS15A,CLCN7,SDHB,TOLLIP,ATF5,DTYMK,HINT1,PPP1R9B,THBS1,OAZ1,MAPKAPK2,FAM162A,SCN2A,HSPH1,RPS21,KIFAP3,GBE1,SLC1A2,PPP2R1B,RPL38,CSTA,CRYAB,WHSC1,RRM2B,CTSG,TMBIM6,CXCL9,PANX1,SLC9A1,ODC1,PTPRC,EMG1,ARID3B,MCOLN3,KEAP1,ATF4,STAM,MYBBP1A,TMSB10/TMSB4X,UNG,TP53,CERS6,RHEB,PPP1R1B,TNFRSF10B,BCL2L14,MAD2L2,FGFR2,DSG1,HAX1,HSPA8,BTG2,GAPDH,DUSP4,AARS,SQSTM1,LYPLA1,ESR2,STEAP3,APOE,NME1,NACC2,OSGIN1,FGF2,GDF15,HSPB8,LGALS9,CD74,GLIPR1,C1QTNF9,OGT,UBE2K,DAB2,ADORA1,HCAR2,NFE2L2,FCGR3A/FCGR3B,S100A1,SIGMAR1,GNA12,SLC39A6,LZTS2,TRIB3,CPEB4,ISG15,GRN,FOS,MYOC,NR4A2,NTRK3,PPT1,PSAP,TPP1,ARHGDIA,TSC22D2,ADRA1A,ICMT,TRAF3,SESN2,ATP2B1,MBP,OGFOD1,NRN1,TYMP,RNASE1,HSPA5,CD28,HSPA4,SAE1,RHOG,RPS13,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,PPP1CA,CBR1,GULP1,PFKFB3,IL2RG,PTPRQ,PPP1R11,SDHC,CITED1,KLF4,SLC3A2,FOSB,ADAM12,CAPN2,PIK3AP1,HTRA1,SIRPA,RPSA,CD151,MSR1,DMD,IL17RA,PDGFC,HNRNPK,RAP1GDS1,IRAK1,CIAPIN1,SLC19A3,TIMP1,SAA1,LOC102724428/SIK1,RHOBTB2,MCRS1,LONP1,ATP13A2,KRT14,VCAM1,NQO1,EMD,PDLIM4,NFE2L1,FGF1,SERPINE2,KIFC3,GIPR,CIDEA,CAPNS1,LGALS2,PSMD2,EIF3I,APOB,ITSN1,SH3GLB1,HRAS,APRT,CXCL10,DYNLL1,CTSS,PIK3CG,ABCC1,TXN,EYA2,STOML2,ANGPTL1,MTPN,CCND2,NR1D1,YARS,STIP1,MBD4,ALDOA,SFRP1,TCF7,CYR61,C3AR1,ITGA7,S100A11,HIST1H1C,ADAM17,RAB32,RPS3A,UBQLN1,PSMB10,DUSP6,CTNNA1,KAZN,PIP,UCHL1,FANCE,CA3,RPL35,ACSM5,GBA,TOP2A,LAMP1,PSMD14,STIM1,NACC1,RPS12,NDUFAB1,MBOAT7,RPS19,LETM1,ADRM1,TYROBP,MT-ND4,APP,EIF3G,ITGB2,MCF2L,COL5A3,LAMP2,SREBF2,FKBP4,MS4A2,PRMT5,PEA15,FCER1G,P2RY12,NR5A2,CYCS,GAB2,SLC7A11,CCNI,PFKFB1,SDC4,TUBB,UBA2,CTBP1,G0S2,ITGAV,CYBB,NEO1,KPNA2,SIAH2,EIF2AK1,MIF,SPP1,GPS2,LMO4,SGCG,PSMC4,PKN1,ADCYAP1R1,IL1RN,ACKR3,MAPK10,GNL3,AKR1B1,VDAC1,LEP,CD2,ERN1,PKM,VAPA,SMPD1,HIF1A,FAS,HMOX1,PARK7,PCK2,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,PSMA3,NSMF,S100A8,NLRC4,PRNP,CD160,TAF6,MAPK9,F13A1,CSF1R,NDUFA13,FAU,ENO1,UBA1,MAT2A,P2RX7	444	
Cell Death and Survival	apoptosis	apoptosis	2.06E-18	Decreased	-4.101	 	-2.081	TGFBR1,AGER,ASS1,PIK3R1,C1QA,POR,EIF3B,CCND3,AIF1,FBL,LAIR1,SURF1,ANXA2,IRF5,CTSB,ALCAM,EPHX1,FTH1,PIM3,GADD45B,DDIT3,DAPK2,ADIPOQ,PPIA,RABL6,GNG5,AMOT,TMEM123,UCP2,ENG,CSTB,NR4A1,RPL37,SOX9,SOCS3,CCT2,FCER1A,CSNK1A1,INTS1,CTSD,NSMAF,STXBP1,GAS5,TXNRD1,AES,RBX1,INSR,ETV5,HSPB1,UBE2I,PEBP1,IGFBP4,SCD,F2RL3,NELFB,DNASE1L3,BARD1,HDGF,HLA-G,ALDH2,EDN1,CFH,STAT1,DVL1,G6PD,CSRNP1,SOD1,RBCK1,SLC25A5,MAP4K4,RPLP0,GFPT1,DDX20,MKI67,EEF1D,GLO1,MIEN1,SGPL1,LGMN,AHSA1,NAPA,ZBTB16,SFT2D2,SFRP4,CAPN6,CKAP2,HMGA1,NINJ1,MNT,DPH2,PRELID1,RTN4,ARHGAP35,GSTP1,HYOU1,SLC1A3,FKBP1A,ASNS,JUN,TUB,FKBP5,ACVR1C,RPS24,WSB1,CD53,TRIM28,EGR1,AIP,PI3,SOX6,GLIS2,USP22,NCAM1,PER1,PFN1,KCND3,CD4,UNC5B,MAP1B,LHCGR,PLCE1,SLC25A6,CAMK2D,CHST11,ANXA7,C1QBP,LANCL1,RET,HK1,PRKRA,HSPA9,GNG2,PHB2,RAC1,TPSAB1/TPSB2,RASD1,MAPT,FMN2,CD14,EIF5A,ATF5,MRPS30,DTYMK,HINT1,PPP1R9B,THBS1,DUSP10,MAPKAPK2,FAM162A,SCN2A,DAP,BHLHE41,HSPH1,PHLDA3,KIFAP3,C6,NCKAP1L,CPEB1,HLTF,PPP2R1B,CSTA,CRYAB,KDM6B,WHSC1,RRM2B,CTSG,TMBIM6,PANX1,SLC9A1,ODC1,PTPRC,GATAD2A,ARID3B,HIGD2A,MCOLN3,KEAP1,ATF4,MYBBP1A,TMSB10/TMSB4X,UNG,TP53,CERS6,RHEB,PPP1R1B,TNFRSF10B,BCL2L14,MAD2L2,FGFR2,RHBDD1,DSG1,HAX1,ARHGDIB,HSPA8,BTG2,GAPDH,DUSP4,AARS,SQSTM1,LYPLA1,ESR2,STEAP3,APOE,NME1,SLC4A2,NACC2,FBXO10,OSGIN1,PHLDA2,FGF2,GDF15,HSPB8,LGALS9,CD74,GLIPR1,C1QTNF9,OGT,DAB2,BCAP31,ADORA1,HCAR2,NFE2L2,FCGR3A/FCGR3B,S100A1,SIGMAR1,SRA1,GNA12,SLC39A6,LZTS2,TRIB3,SNCG,HSPA2,CPEB4,ISG15,GRN,FOS,MYOC,NR4A2,NTRK3,PPT1,PSAP,ARHGDIA,ADRA1A,ICMT,TRAF3,DAD1,NME2,OGFOD1,TYMP,RNASE1,HSPA5,BIN1,CD28,HSPA4,SAE1,RHOG,ENTPD5,PACS2,NUPR1,HOXA7,GCLM,DPM3,PPP1CA,IL2RG,PTPRQ,PPP1R11,SDHC,CITED1,KLF4,FOSB,ADAM12,CAPN2,PIK3AP1,HTRA1,TFPT,SIRPA,CD151,PTGFR,MSR1,PDGFC,HNRNPK,IRAK1,CIAPIN1,TIMP1,SAA1,PPP1R2,ADCK3,LOC102724428/SIK1,RHOBTB2,MCRS1,KRT14,NQO1,EMD,PDLIM4,DEGS1,NFE2L1,AIFM2,FGF1,SERPINE2,KIFC3,CIDEA,CAPNS1,LGALS2,EIF3I,ITSN1,SH3BGRL3,SH3GLB1,NCSTN,HRAS,CXCL10,DYNLL1,CTSS,ABCC1,PIK3CG,TXN,EYA2,CFL1,STOML2,ANGPTL1,MTPN,CCND2,NR1D1,YARS,PTPA,STIP1,MBD4,IL10RA,ALDOA,SFRP1,CYR61,C3AR1,ITGA7,S100A11,HIST1H1C,ADAM17,RAB32,RPS3A,PSMB10,UBQLN1,PAM16,DUSP6,CTNNA1,KAZN,PIP,UCHL1,CA3,ACSM5,ANXA5,TOP2A,STIM1,NACC1,AMFR,MBOAT7,RPS19,TYROBP,MT-ND4,AREL1,APP,ITGB2,MCF2L,FIS1,SUPV3L1,COL5A3,SREBF2,FKBP4,MS4A2,PRMT5,PEA15,FCER1G,TSPO,CYCS,CBX4,GABARAP,GAB2,SLC7A11,CCNI,SDC4,TAF10,UBA2,CTBP1,G0S2,ITGAV,CYBB,KPNA2,SIAH2,EIF2AK1,MIF,SPP1,GPS2,LMO4,SGCG,PKN1,SEL1L,ADCYAP1R1,IL1RN,MAPK10,GNL3,AKR1B1,VDAC1,PAFAH1B2,DDAH2,LEP,CD2,PRDX5,ERN1,PKM,SMPD1,HIF1A,FAS,TNFRSF12A,HMOX1,PARK7,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,SLC40A1,NSMF,S100A8,STK40,NLRC4,PRNP,CD160,TAF6,MAPK9,CSF1R,NDUFA13,KCNQ4,FAU,ENO1,UBA1,MAT2A,P2RX7	434	
Neurological Disease, Skeletal and Muscular Disorders	neuromuscular disease	neuromuscular disease	3.55E-17	 	0.246	 	0.433	TUBA1B,GFPT1,CRYAB,AHCYL1,RRM2B,TOR1A,RAN,HRAS,GHITM,HLA-DQB1,GNB1,PTPRC,CTSS,KEAP1,HADHB,ATF4,CHCHD2,SYT2,TXN,NAPA,ZBTB16,FBL,ATP5J,TP53,POLR2I,PPP1R1B,SLC24A3,CSRP2,SURF1,TPM3,FLOT1,ANXA2,CD52,ARHGDIB,NGRN,HSPA8,NR1D1,CD68,TMEM55A,PSMA4,RTN4,GAPDH,ALCAM,SQSTM1,NDUFB2,GSTP1,FTH1,APOE,FCGRT,NME1,GJB6,ADAM17,RPS3A,DDIT3,GBP1,SRD5A1,FGF2,SLC1A3,HLA-DQA1,PPIA,FKBP1A,KAZN,CD74,UCHL1,CA3,TMEFF1,JUN,GBA,MAL2,TNXB,HLA-DRA,TOP2A,LAMP1,ADORA1,RPL31,FCGR3A/FCGR3B,MYL12A,FCGR2A,EGR1,RPL17,SLIRP,TRIB3,SNCG,PSMB6,ISG15,APP,MYO5A,FOS,FTL,LAMP2,MT-ND1,PSME1,NR4A2,UQCR10,NR4A1,FKBP4,TSPO,CYCS,SOX9,ADRA1A,MT-TT,PFN1,PFKFB1,KCND3,ATP2B1,MBP,MAP1B,ATP5L,SDC4,DYNLT1,HSPA5,TRIM31,LDHB,AK1,SLC25A6,RHOG,COMT,TUBA1C,MIF,SPP1,GAS5,GPS2,ATP6V1A,LMCD1,IL1RN,MAPT,RARRES3,NDUFS3,HSPB1,MT-TP,RPSA,ETV5,PEBP1,SCD,SRM,SUMO3,COX7B,SDHB,LEP,SLC1A4,PKM,ALAS1,NDUFA2,RPS4X,FAS,NELFE,FARSB,HLA-G,HMOX1,ALDH2,HINT1,PARK7,PREPL,KCNMA1,ANXA1,PPP1R2,VCP,ATP13A2,PRNP,PSAT1,SCN2A,MT-ND6,ADCY2,CD160,CAPZB,DNAJC1,SOD1,TSN,GIT1,NDUFA13,ATP6V1E1,MT-ND5,KCTD13,CAPNS1,SLC14A1,DNAJB11,SLC1A2,P2RX7,ATP6V1B2	179	
Protein Synthesis	metabolism	metabolism of protein	1.22E-16	Increased	2.671	 	0.831	SPCS1,CSTA,CRYAB,APOB,PIK3R1,CTSG,SH3GLB1,NCSTN,ODC1,SNX12,PTPRC,LGMN,EIF3B,CTSS,ATF4,MYBBP1A,GPR26,TP53,RHEB,NANOS1,KLHL25,MAD2L2,CPA3,RHBDD1,DSG1,HSPA8,MTPN,CTSA,MRPL17,STIP1,BTG2,CTSB,GAPDH,SQSTM1,SFRP1,PLTP,RPL41,MT-TL1,BANK1,APOE,ADAM17,RPS3A,DDIT3,FGF2,DPM2,HSPB8,ADIPOQ,FKBP1A,MRPL39,H2AFZ,PIP,UCHL1,OGT,JUN,GBA,LAMP1,UBE2K,AAK1,PSMD14,ASPH,RPS5,SARS,AMFR,MT-TD,RPS24,ADRM1,MT-TY,RPL17,CSTB,CPEB4,PSMD8,APP,HIST1H1B,EIF3G,FOS,LAMP2,MRPL51,FAM129A,DERL1,TPP1,RPL37,DVL3,SOX9,SOCS3,GAB2,MT-TT,TRAF3,PFN1,CMA1,CD4,CCT2,OGFOD1,SDC4,HSPA5,CTSD,CNDP2,ZNRF3,EIF3D,DPP3,CCT5,RPL19,IFI30,SIAH2,GPC1,RILP,DPM3,PPP1CA,CHMP1A,VPS11,EIF2AK1,PRKRA,STXBP1,SPP1,PCSK6,PSMC4,PHB2,AURKAIP1,MT-TC,UBA6,MT-TE,MARS,EPRS,SEL1L,UBE2D2,SPINK5,ADAM12,IL1RN,EDEM1,MAPT,UBE2G1,FMN2,NAGLU,CAPN2,RPS15A,EIF5A,INSR,HTRA1,UBE2E1,CNBP,UBE2I,HSPB1,MT-TP,UBXN1,RNF165,LEP,ERN1,SLC7A1,MAN1B1,RPS4X,HNRNPK,FAS,MT-TN,FARSB,PARK7,EDN1,THBS1,FLNA,ANXA1,PPP1R2,VCP,TRABD2A,MT-TS1,SENP3,OAZ1,ARHGEF2,LONP1,ATP13A2,PRNP,NACA,MT-TQ,DVL1,RAB7A,RPL30,DNAJC1,SOD1,MKNK2,RPS29,NDUFA13,SERPINE2,WARS,CAPNS1,PSMD2,RPS27L,EIF3I,CPEB1,P2RX7,UBE2D3,RPL38	188	
Cell Death and Survival	cell death	cell death of tumor cell lines	8.87E-16	Decreased	-3.589	 	-2.801	CSTA,CRYAB,WHSC1,TGFBR1,AGER,PIK3R1,RRM2B,CTSG,TMBIM6,SLC9A1,ODC1,PTPRC,EMG1,CCND3,ARID3B,MCOLN3,KEAP1,ATF4,MYBBP1A,TMSB10/TMSB4X,TP53,CERS6,YWHAG,LAIR1,PPP1R1B,TNFRSF10B,FGFR2,ANXA2,IRF5,HAX1,DSG1,HSPA8,BTG2,CTSB,GAPDH,ALCAM,DUSP4,SQSTM1,LYPLA1,ESR2,FTH1,APOE,NME1,NACC2,GADD45B,PSMD7,DDIT3,DAPK2,OSGIN1,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,PPIA,GLIPR1,OGT,RABL6,UBE2K,DAB2,ADORA1,HCAR2,NFE2L2,TMEM123,UCP2,SLC39A6,LZTS2,ENG,TRIB3,GRN,FOS,NR4A2,NTRK3,PPT1,NR4A1,PSAP,ARHGDIA,SOX9,TSC22D2,ICMT,SOCS3,TRAF3,YWHAH,SESN2,ATP2B1,MBP,CCT2,CSNK1A1,FCER1A,OGFOD1,TYMP,RNASE1,HSPA5,CD28,CTSD,HSPA4,SAE1,ENTPD5,PACS2,NUPR1,CCT5,HOXA7,PPP1CA,CBR1,GULP1,PTPRQ,PPP1R11,SDHC,KLF4,TXNRD1,SLC3A2,FOSB,RBX1,CAPN2,INSR,HTRA1,SIRPA,HSPB1,PEBP1,IGFBP4,SCD,MSR1,BARD1,PDGFC,HNRNPK,IRAK1,RAP1GDS1,HLA-G,EDN1,TIMP1,RHOBTB2,CFH,MCRS1,STAT1,LONP1,ATP13A2,KRT14,DVL1,NQO1,G6PD,SOD1,PDLIM4,NFE2L1,KIFC3,CAPNS1,PSMD2,SLC25A5,RPLP0,APOB,ITSN1,HRAS,SH3GLB1,GLO1,DYNLL1,AHSA1,ABCC1,AFAP1,TXN,NAPA,ZBTB16,SFRP4,CAPN6,STOML2,CKAP2,HMGA1,DPH2,CCND2,YARS,RTN4,SFRP1,CYR61,GSTP1,S100A11,ADAM17,RAB32,BTG3,UBQLN1,KAZN,FKBP1A,ASNS,FANCE,UCHL1,ACSM5,JUN,TOP2A,LAMP1,PSMD14,STIM1,NACC1,FKBP5,ACVR1C,RPS24,WSB1,RPS19,ADRM1,LETM1,SYNGR2,TRIM28,EGR1,APP,EIF3G,PI3,LAMP2,USP22,PEA15,PRMT5,CYCS,NCAM1,PER1,SLC7A11,PFKFB1,CD4,UNC5B,UBA2,CTBP1,G0S2,SLC25A6,ITGAV,KPNA2,SIAH2,GPC1,RET,HK1,PRKRA,MIF,SPP1,GPS2,LMO4,HSPA9,PHB2,RAC1,PKN1,RASD1,ACKR3,IL1RN,MAPT,MAPK10,CLCN7,EIF5A,VDAC1,AKR1B1,LEP,TOLLIP,ERN1,PKM,SMPD1,HIF1A,DTYMK,FAS,HMOX1,HINT1,PARK7,PCK2,THBS1,VCP,TGFB2,KIT,OAZ1,S100A8,MAPKAPK2,NLRC4,PRNP,TAF6,CD160,MAPK9,CSF1R,NDUFA13,FAU,ENO1,GBE1,MAT2A,PPP2R1B	272	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of tumor cell lines	9.31E-16	Increased	3.842	 	1.555	TGFBR1,WHSC1,AGER,PIK3R1,CTSG,SLC9A1,CLIP1,ODC1,POR,CCND3,AJUBA,KEAP1,MYBBP1A,TMSB10/TMSB4X,TP53,RBM38,LCP1,YWHAG,LAIR1,PPP1R1B,TNFRSF10B,FLOT1,FGFR2,ANXA2,MYL9,BTG2,PSMA4,CTSB,GAPDH,ALCAM,DUSP4,ESR2,STEAP3,FTH1,NME1,NACC2,DDIT3,DAPK2,OSGIN1,FGF2,GDF15,EEF1B2,ADIPOQ,HSPB8,COPS8,GLIPR1,SYNM,OGT,RABL6,TMEFF1,PTPRJ,TNXB,DAB2,ASPH,AMOT,NFE2L2,KRT10,S100A1,IGKC,SLC39A6,ENG,IPO7,TRIB3,SNCG,GRN,FOS,NR4A2,NTRK3,PPT1,WBP2,NR4A1,SOX9,DCX,PPIL1,ABCB6,PRKACB,SOCS3,AKR1C3,SEPT9,USP5,CSNK1A1,NME2,CES2,HSPA5,BIN1,CD28,CTSD,SAE1,CYP3A5,ENTPD5,HOXA7,MT-ND2,ADAMTS5,PFKFB3,IL2RG,PTPRQ,MFSD14A,CREG1,UBA6,CITED1,KLF4,SLC3A2,FOSB,PIK3R3,SDCBP,ADAM12,RBX1,INSR,CST6,UBE2I,RPSA,HSPB1,INO80B,CD151,PEBP1,SUMO3,IGFBP4,SCD,BARD1,PDGFC,HNRNPK,HDGF,RAP1GDS1,EDN1,LOC102724428/SIK1,RHOBTB2,MCRS1,CIZ1,STAT1,KRT14,VCAM1,SLC9A3R1,USMG5,DVL1,NQO1,G6PD,SOD1,PDLIM4,CISD2,GIT1,DEGS1,FGF1,RBCK1,CISD1,TBC1D7,MAP4K4,APOB,RAN,HRAS,NCSTN,MKI67,CXCL10,PEG10,AHSA1,PIK3CG,AFAP1,TXN,ZBTB16,SFRP4,CAPN6,TUBB2A,HMGA1,SSBP1,CCND2,PIP5K1C,ALDOA,SFRP1,CYR61,ITGA7,ADAM17,DUSP6,ASNS,H2AFZ,ENAH,S100A7,UCHL1,CA3,JUN,SLC19A1,STIM1,FKBP5,ACVR1C,WSB1,PTPRK,TRIM28,EGR1,COPS3,APP,FTL,SOX6,RNF144A,FCER1G,PRMT5,TSPO,NR5A2,DVL3,NCAM1,GAB2,PFN1,SLC7A11,ARF1,CD4,MAP1B,SDC4,TUBB,UBA2,CTBP1,PGD,CAMK2D,SLC25A6,PLCE1,ITGAV,NEO1,SLC7A5,KPNA2,ANXA7,GPC1,C1QBP,RET,CLCN3,HK1,EIF2AK1,MIF,SPP1,GSDMB,GPS2,RAC1,RASD1,CMC2,SEL1L,ZFAND3,ACKR3,IL1RN,SH2B3,RARRES3,GNL3,EIF5A,UBE2J2,SRM,COPS4,LEP,EPB41L3,ATF5,PDGFA,PKM,HIF1A,NAA10,HMOX1,SLFN5,PPP1R9B,PCK2,THBS1,FLNA,ANXA1,VCP,TGFB2,KIT,OAZ1,ARHGEF2,NR2F6,MAPKAPK2,ACTN1,PRNP,NDUFAF3,NACA,ADAMTS15,TAF6,CD160,VANGL1,MAPK9,MKNK2,NDUFA13,TRPM6,TMEM2,UBA1,P2RX7,UBE2D3	277	
Cellular Movement	cell movement	cell movement	9.89E-16	Increased	5.570	bias	0.755	CRYAB,TGFBR1,WHSC1,KDM6B,AGER,PIK3R1,CTSG,CXCL9,SLC9A1,PPP1R14B,SPRY4,GNB1,PTPRC,SRPX2,ATG9A,AJUBA,KEAP1,ST6GALNAC2,SCPEP1,PLXNB2,LMX1A,AIF1,TMSB10/TMSB4X,TP53,LCP1,DPT,MTSS1,PAQR3,TMEM201,CARMIL1,FGFR2,TPM3,FLOT1,ANXA2,IRF5,ARHGDIB,HAX1,RCC2,BTG2,CTSB,GAPDH,ALCAM,DUSP4,SQSTM1,PLTP,ELMO2,ESR2,FTH1,APOE,RAP2A,NME1,GJB6,FHL1,SLC4A2,ARPC1B,GBP1,DAPK2,FGF2,PHLDA2,OSGIN1,SNX17,FAM89B,GDF15,ADIPOQ,LGALS9,PPIA,CD74,SYNM,PTPRJ,DAB2,ASPH,ADORA1,AMOT,HCAR2,NFE2L2,KRT10,FCGR3A/FCGR3B,P4HA2,CCR1,S100A1,UCP2,FCGR2A,GNA12,ANOS1,MESP1,ALOX5AP,ENG,IPO7,SNCG,GRN,MYO5A,FOS,MT-ND1,MYOC,NR4A2,NTRK3,FLNC,NR4A1,WBP2,ARHGDIA,SOX9,SEMA3C,DCX,SOCS3,SEPT9,USP5,MBP,NME2,FCER1A,TYMP,HSPA5,CD28,RHOG,CXCL14,ELP5,HOXA7,STAB1,TUBA1C,CDC42EP1,PCSK6,HNRNPAB,DMTN,CAPG,FYB,KLF4,SLC3A2,FOSB,SDCBP,ADAM12,CAPN2,INSR,HTRA1,CST6,TNS1,SIRPA,UBE2I,HSPB1,RPSA,ETV5,CD151,PEBP1,IGFBP4,LITAF,F2RL3,MSR1,PLGRKT,FAT3,DMD,IL17RA,HNRNPK,HDGF,HLA-G,ALDH2,EDN1,TIMP1,SAA1,RNH1,RHOBTB2,IGSF8,CFH,STAT1,THBS4,VCAM1,SLC9A3R1,SLC12A2,NQO1,G6PD,ST3GAL6,EMD,TRPA1,SOD1,SNX27,S100A2,GIT1,FGF1,SERPINE2,CXCL16,APLP2,CAPNS1,KIF5B,CXXC5,MAP4K4,APOB,ITGA8,HRAS,MIEN1,CHST2,CXCL10,BCAT1,SGPL1,DGCR6L,LGMN,ABR,CTSS,ABCC1,PIK3CG,AFAP1,TXN,ZBTB16,EYA2,WNT5B,SFRP4,CFL1,HMGA1,NINJ1,SPON2,ANGPTL1,NR1D1,PIP5K1C,YARS,MS4A4A,IL10RA,RTN4,ALDOA,ARHGAP35,RAMP3,SFRP1,CYR61,C3AR1,LCP2,S100A11,ADAM17,HLA-A,DUSP6,CTNNA1,HYOU1,SLC1A3,SDC3,ASNS,ENAH,S100A7,LYZ,CES1,JUN,GBA,SRGAP1,CCL28,ANXA5,STIM1,SARS,GJB2,CALML3,MYL12A,MBOAT7,RPS19,PLXNA1,CD209,PTPRK,KRT6B,TYROBP,EGR1,EPB41L4B,SLIRP,APP,MCF2L,ITGB2,GLIS2,TREM2,FCER1G,FKBP4,PRMT5,TSPO,P2RY12,RUFY3,NCAM1,GAB2,PER1,PLCB2,PFN1,ARF1,CMA1,CD4,MAP1B,UNC5B,SDC4,TUBB,CD63,MTCH2,CTBP1,NARS,RSPO3,CAMK2D,CYBB,ITGAV,NEO1,KPNA2,SIAH2,GPC1,C1QBP,RET,CLCN3,SHOC2,PTX3,MIF,SPP1,LMO4,GSDMB,PHB2,RAC1,TARS,PKN1,TPSAB1/TPSB2,LMCD1,EFS,PREX1,ACKR3,IL1RN,SH2B3,MAPT,MAPK10,CD14,AKR1B1,LEP,CD2,PDGFA,PKM,SMPD1,HIF1A,PLPP1,RAMP2,FAS,TNFRSF12A,CLCN4,HMOX1,PARK7,THBS1,FLNA,KCNMA1,ANXA1,DUSP10,VCP,TGFB2,KIT,CYGB,S100A8,MAPKAPK2,NLRC4,PRNP,NDUFAF3,NACA,TPST2,BHLHE41,MRC2,F13A1,MAPK9,CSF1R,PLXND1,ENO1,KIF2A,WARS,EPHB3,SLC1A2,C6,NCKAP1L,CPEB1,P2RX7	356	
Cellular Movement	migration	migration of cells	1.71E-15	Increased	5.528	bias	0.926	CRYAB,TGFBR1,KDM6B,WHSC1,AGER,PIK3R1,CTSG,CXCL9,SLC9A1,PPP1R14B,SPRY4,PTPRC,SRPX2,ATG9A,AJUBA,KEAP1,SCPEP1,PLXNB2,LMX1A,AIF1,TMSB10/TMSB4X,TP53,LCP1,DPT,PAQR3,TMEM201,CARMIL1,FGFR2,TPM3,FLOT1,ANXA2,IRF5,ARHGDIB,HAX1,RCC2,BTG2,CTSB,ALCAM,DUSP4,PLTP,ELMO2,ESR2,FTH1,APOE,RAP2A,NME1,GJB6,FHL1,SLC4A2,DAPK2,FGF2,PHLDA2,OSGIN1,SNX17,GDF15,ADIPOQ,LGALS9,PPIA,CD74,SYNM,PTPRJ,DAB2,ASPH,ADORA1,AMOT,HCAR2,NFE2L2,KRT10,FCGR3A/FCGR3B,P4HA2,CCR1,UCP2,FCGR2A,GNA12,MESP1,ALOX5AP,ENG,IPO7,SNCG,GRN,FOS,MT-ND1,MYOC,NR4A2,NTRK3,FLNC,NR4A1,WBP2,ARHGDIA,SOX9,SEMA3C,DCX,SOCS3,SEPT9,USP5,NME2,FCER1A,HSPA5,CD28,RHOG,CXCL14,ELP5,HOXA7,STAB1,CDC42EP1,PCSK6,DMTN,CAPG,FYB,KLF4,SLC3A2,SDCBP,ADAM12,CAPN2,INSR,CST6,TNS1,SIRPA,UBE2I,RPSA,HSPB1,ETV5,CD151,IGFBP4,LITAF,F2RL3,MSR1,PLGRKT,FAT3,IL17RA,HNRNPK,HDGF,HLA-G,EDN1,TIMP1,SAA1,RNH1,RHOBTB2,IGSF8,CFH,STAT1,THBS4,VCAM1,SLC9A3R1,SLC12A2,NQO1,G6PD,ST3GAL6,TRPA1,SOD1,S100A2,GIT1,FGF1,SERPINE2,CXCL16,APLP2,CAPNS1,CXXC5,MAP4K4,APOB,ITGA8,HRAS,MIEN1,CHST2,CXCL10,BCAT1,SGPL1,DGCR6L,LGMN,ABR,CTSS,ABCC1,PIK3CG,AFAP1,TXN,ZBTB16,EYA2,WNT5B,SFRP4,CFL1,NINJ1,SPON2,ANGPTL1,NR1D1,PIP5K1C,YARS,MS4A4A,IL10RA,RTN4,ALDOA,ARHGAP35,RAMP3,SFRP1,CYR61,C3AR1,LCP2,S100A11,ADAM17,HLA-A,DUSP6,CTNNA1,HYOU1,SLC1A3,SDC3,ASNS,ENAH,S100A7,LYZ,CES1,JUN,GBA,SRGAP1,CCL28,ANXA5,STIM1,SARS,GJB2,CALML3,MYL12A,MBOAT7,RPS19,PLXNA1,CD209,PTPRK,KRT6B,TYROBP,EGR1,EPB41L4B,APP,MCF2L,ITGB2,GLIS2,TREM2,FCER1G,FKBP4,PRMT5,TSPO,P2RY12,RUFY3,NCAM1,GAB2,PER1,PLCB2,PFN1,ARF1,CMA1,CD4,MAP1B,UNC5B,SDC4,CD63,CTBP1,NARS,RSPO3,CAMK2D,CYBB,ITGAV,NEO1,KPNA2,SIAH2,GPC1,C1QBP,RET,CLCN3,SHOC2,PTX3,MIF,SPP1,LMO4,PHB2,RAC1,TARS,PKN1,TPSAB1/TPSB2,LMCD1,EFS,PREX1,ACKR3,IL1RN,SH2B3,MAPT,MAPK10,CD14,LEP,CD2,PDGFA,PKM,SMPD1,HIF1A,PLPP1,RAMP2,FAS,TNFRSF12A,CLCN4,HMOX1,PARK7,THBS1,FLNA,KCNMA1,ANXA1,DUSP10,VCP,TGFB2,KIT,CYGB,S100A8,MAPKAPK2,NLRC4,PRNP,NDUFAF3,NACA,BHLHE41,MRC2,MAPK9,F13A1,PLXND1,CSF1R,KIF2A,WARS,EPHB3,SLC1A2,C6,NCKAP1L,CPEB1,P2RX7	325	
Neurological Disease, Psychological Disorders	disorder of basal ganglia	disorder of basal ganglia	1.73E-15	Decreased	-2.600	bias	-1.666	TUBA1B,CRYAB,AHCYL1,TOR1A,RAN,HRAS,GHITM,GNB1,CTSS,HADHB,PNKD,ATF4,CHCHD2,TXN,NAPA,ZBTB16,TP53,POLR2I,FBL,ATP5J,CSRP2,PPP1R1B,TUBB2A,TPM3,FLOT1,ANXA2,ARHGDIB,NGRN,HSPA8,NR1D1,CD68,TMEM55A,RTN4,GAPDH,GSTP1,NDUFB2,FTH1,APOE,NME1,GJB6,RPS3A,DDIT3,GBP1,SRD5A1,FGF2,SLC1A3,PPIA,KAZN,CD74,UCHL1,TMEFF1,JUN,GBA,MAL2,LAMP1,ADORA1,NFE2L2,RPL31,MYL12A,TUBB4B,EGR1,RPL17,SLIRP,TRIB3,SNCG,PSMB6,APP,ISG15,MYO5A,FOS,FTL,MT-ND1,PSME1,LAMP2,NR4A2,UQCR10,NR4A1,FKBP4,TSPO,CYCS,SOX9,ADRA1A,MT-TT,PFN1,PFKFB1,ATP2B1,MBP,MAP1B,ATP5L,SDC4,DYNLT1,HSPA5,LDHB,CERS2,AK1,SLC25A6,RHOG,COMT,TUBA1C,SPP1,GAS5,GPS2,ATP6V1A,LMCD1,FOSB,MAPT,RARRES3,NDUFS3,RPSA,HSPB1,MT-TP,ETV5,PEBP1,SCD,SRM,SUMO3,COX7B,SDHB,LEP,SLC1A4,PKM,ALAS1,NDUFA2,RPS4X,FARSB,SLC19A3,HMOX1,ALDH2,HINT1,PARK7,PREPL,PPP1R2,ATP13A2,PRNP,PSAT1,SCN2A,MT-ND6,ADCY2,MT-ATP6,CAPZB,CD160,TUBG1,DNAJC1,SOD1,TSN,GIT1,NDUFA13,ATP6V1E1,KCTD13,MT-ND5,CAPNS1,SLC14A1,SLC1A2,PDE8B,ATP6V1B2	155	
Neurological Disease	progressive motor neuropathy	progressive motor neuropathy	8.79E-15	 	-0.119	 	-0.160	TUBA1B,CRYAB,C9orf72,RRM2B,TOR1A,RAN,HLA-DQB1,SUSD1,FADS3,PTPRC,CTSS,KEAP1,ATF4,CHCHD2,TP53,SLC24A3,FLOT1,ANXA2,CD52,ARHGDIB,TMEM55A,RTN4,ALCAM,SQSTM1,CYR61,GSTP1,FTH1,APOE,ADAM17,RPS3A,TCEA1,CHCHD10,DDIT3,FGF2,HLA-DQA1,SLC1A3,CD74,UCHL1,GBA,TNXB,ANXA5,HLA-DRA,TOP2A,LAMP1,ADORA1,RPL31,SLC7A6,FCGR3A/FCGR3B,ALDH5A1,SIGMAR1,FCGR2A,EGR1,RPL17,TRIB3,SNCG,APP,ISG15,GRN,CALM1 (includes others),FTL,MT-ND1,NR4A2,SREBF2,PSAP,TSPO,ADRA1A,MT-TT,PFN1,KCND3,MBP,CCT2,MAP1B,ZNF91,TRIM31,HSPA5,LDHB,NNMT,SLC25A6,COMT,TUBA1C,FUCA1,MIF,SPP1,GPS2,MAPT,FMN2,CAPN2,MT-TP,HSPB1,PEBP1,SUMO3,SLC1A4,PDGFC,RPS4X,FAS,NELFE,FARSB,HLA-G,PARK7,KCNMA1,TIMP1,ANXA1,VCP,ATP13A2,PRNP,SCN2A,MT-ND6,CAPZB,DNAJC1,SOD1,ATP6V1E1,MT-ND5,DNAJB11,SLC1A2,P2RX7	115	
Connective Tissue Disorders, Skeletal and Muscular Disorders	arthropathy	arthropathy	1.63E-14	Increased	2.781	 	2.260	TMEM266,CRYAB,C9orf72,AGER,CTSG,C1QA,CLSTN2,HLA-DQB1,CXCL9,PTPRC,SKIV2L,CXCL10,DYNLL1,IP6K3,CCND3,CTSS,ABCC1,PIK3CG,CHCHD2,TXN,AIF1,HIST1H2AC,WNT5B,TP53,CERS6,RBM38,LCP1,TNFRSF10B,TUBB2A,IRF5,ARHGDIB,HSPA8,TMEM127,CD68,PIP5K1C,CNTNAP4,IL10RA,MS4A7,CTSB,ALDOA,GLUL,TCF7,ITGA7,C3AR1,FTH1,APOE,FCGRT,GADD45B,DDIT3,MS4A6A,FGF2,HLA-A,HSPB8,SLC1A3,HLA-DQA1,ADIPOQ,ST6GALNAC4,FKBP1A,GPC4,SDC3,CD74,LYZ,TNXB,HLA-DRA,SLC19A1,FKBP5,ALPK2,RPL31,FCGR3A/FCGR3B,MYL12A,RPS24,CCR1,SIGMAR1,TYROBP,FCGR2A,TUBB4B,IGKC,TRIM28,ALOX5AP,PLA2G2A,GRN,FOS,ITGB2,FTL,RPS16,NR4A2,FCER1G,NR4A1,TSPO,ADRA1A,SOCS3,SLC7A11,ARF1,PRMT3,CD4,SDC4,HSPA5,TRIM31,LDHB,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,TUBA1C,CNTNAP1,RET,RFLNB,ADAMTS5,RPL32,MIF,SPP1,LMO4,RAB10,PHB2,PPP1R11,TPSAB1/TPSB2,FOSB,SEL1L,IL1RN,SLC7A2,FMN2,NAGLU,CAPN2,HTRA1,RPSA,IGFBP4,LEP,SLC1A4,MSR1,PRDX5,ERN1,BARD1,SLC7A1,TPGS2,CD83,IL17RA,RAMP2,FAS,NELFE,HLA-G,HMOX1,SLFN5,EDN1,RPL18A,CCSER2,TIMP1,THBS1,ANXA1,SAA1,TGFB2,KIT,S100A8,STAT1,MAPKAPK2,ALPL,NLRC4,PRNP,ADAMTS15,C14orf2,SCN2A,VCAM1,TUBG1,NQO1,VSIG4,F13A1,CSF1R,ATIC,FAU,CXCL16,ENO1,APLP2,DYM,SLC1A2,UBA1,C6,EFEMP2,MAP4K4,HLTF,P2RX7	183	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of myeloid cells	2.01E-14	Increased	3.522	bias	0.562	CRYAB,AGER,PIK3R1,CTSG,HRAS,CXCL9,CXCL10,PTPRC,CTSS,PIK3CG,TXN,AIF1,TMSB10/TMSB4X,TP53,FLOT1,ANXA2,NINJ1,SPON2,YARS,PIP5K1C,MS4A4A,RTN4,CTSB,PLTP,SFRP1,CYR61,C3AR1,APOE,ADAM17,DAPK2,GDF15,ADIPOQ,LGALS9,PPIA,CD74,S100A7,CES1,GBA,PTPRJ,CCL28,STIM1,ADORA1,HCAR2,NFE2L2,GJB2,CCR1,RPS19,TYROBP,FCGR2A,ALOX5AP,ENG,APP,GRN,ITGB2,MT-ND1,GLIS2,TREM2,FCER1G,NR4A1,SOCS3,PLCB2,PFN1,CD4,CMA1,UNC5B,CD28,RSPO3,CXCL14,ITGAV,CYBB,STAB1,NEO1,C1QBP,PTX3,MIF,SPP1,RAC1,CAPG,TPSAB1/TPSB2,PREX1,IL1RN,SH2B3,CD14,SIRPA,CD151,HSPB1,LITAF,LEP,MSR1,CD2,HIF1A,IL17RA,FAS,HMOX1,EDN1,FLNA,THBS1,TIMP1,SAA1,DUSP10,ANXA1,TGFB2,KIT,S100A8,CFH,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NQO1,MAPK9,GIT1,PLXND1,CSF1R,C6,NCKAP1L,P2RX7	118	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial myopathy	mitochondrial myopathy	2.08E-14	 	 	 	 	MT-TT,NDUFA9,RRM2B,TYMP,NDUFA2,SCO2,MT-CYB,MT-CO3,MT-ND2,NDUFS4,MT-CO1,MT-ATP6,MT-ND6,MT-TY,MT-TQ,SURF1,MT-ND4,MT-TC,MT-TE,MT-ND4L,MT-ND1,MT-ND5,NDUFS8,NDUFA12,MT-ND3,NDUFS3,MT-TP,MT-TL1	28	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	inflammation	inflammation of joint	2.14E-14	Increased	2.786	 	2.245	TMEM266,CRYAB,C9orf72,AGER,CTSG,C1QA,CLSTN2,HLA-DQB1,CXCL9,PTPRC,SKIV2L,CXCL10,DYNLL1,IP6K3,CCND3,CTSS,ABCC1,PIK3CG,CHCHD2,TXN,AIF1,HIST1H2AC,WNT5B,TP53,CERS6,RBM38,LCP1,TNFRSF10B,TUBB2A,IRF5,ARHGDIB,HSPA8,TMEM127,CD68,CNTNAP4,IL10RA,MS4A7,CTSB,ALDOA,GLUL,TCF7,ITGA7,C3AR1,FTH1,APOE,FCGRT,GADD45B,DDIT3,MS4A6A,FGF2,HLA-A,HSPB8,SLC1A3,HLA-DQA1,ADIPOQ,ST6GALNAC4,FKBP1A,GPC4,SDC3,CD74,LYZ,TNXB,HLA-DRA,SLC19A1,FKBP5,ALPK2,RPL31,FCGR3A/FCGR3B,MYL12A,RPS24,CCR1,SIGMAR1,TYROBP,FCGR2A,TUBB4B,IGKC,TRIM28,ALOX5AP,PLA2G2A,GRN,FOS,ITGB2,FTL,RPS16,NR4A2,FCER1G,NR4A1,TSPO,ADRA1A,SOCS3,SLC7A11,ARF1,PRMT3,CD4,SDC4,HSPA5,TRIM31,LDHB,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,TUBA1C,RET,RFLNB,ADAMTS5,RPL32,MIF,SPP1,LMO4,RAB10,PHB2,PPP1R11,TPSAB1/TPSB2,FOSB,SEL1L,IL1RN,SLC7A2,FMN2,NAGLU,CAPN2,HTRA1,RPSA,IGFBP4,LEP,SLC1A4,MSR1,PRDX5,ERN1,BARD1,SLC7A1,TPGS2,CD83,IL17RA,RAMP2,FAS,NELFE,HLA-G,HMOX1,SLFN5,EDN1,RPL18A,CCSER2,TIMP1,THBS1,ANXA1,SAA1,TGFB2,KIT,S100A8,STAT1,MAPKAPK2,ALPL,NLRC4,PRNP,ADAMTS15,C14orf2,SCN2A,VCAM1,TUBG1,NQO1,VSIG4,F13A1,CSF1R,ATIC,FAU,CXCL16,ENO1,APLP2,DYM,SLC1A2,C6,EFEMP2,MAP4K4,HLTF,P2RX7	180	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	hereditary myopathy	hereditary myopathy	2.44E-14	 	-1.125	bias	 	MT-TT,CRYAB,SLC7A11,NDUFA9,KCND3,SEPT9,RRM2B,SNTA1,GARS,TYMP,C1QB,HLA-DQB1,HSPA5,BIN1,GSS,SCO2,GYS1,CCND3,CXCL14,IFI30,MTMR2,MT-ND2,HK1,CFL1,SGCG,CSRP2,TUBB2A,SURF1,MT-TC,MT-TE,MT-ND4L,MARS,GYS2,SDCBP,TLN2,YARS,PSMA4,NAGLU,NDUFA12,AARS,MT-ND3,SQSTM1,NDUFS3,ITGA7,CNBP,HSPB1,MT-TL1,MT-TP,S100A11,LITAF,FHL1,CHCHD10,HLA-A,HSPB8,FKBP1A,DMD,HIF1A,SDC3,NDUFA2,TAX1BP3,HINT1,MT-CYB,VCP,HLA-DRA,DAB2,MT-CO3,STIM1,ISCU,NDUFS4,PRNP,MT-CO1,SIGMAR1,MT-ND6,MT-ATP6,COL5A2,MT-TY,MT-TQ,MTMR14,RAB7A,EMD,MT-ND4,ENG,POMGNT1,FGF1,APP,RBCK1,MT-ND5,LAMP2,MT-ND1,NDUFS8,FLNC,SBF1,CYCS,UBA1,ADRA1A	95	
Neurological Disease	movement disorder	Movement Disorders	3.17E-14	Decreased	-5.053	bias	 	CRYAB,CA5B,SLC9A1,GNB1,GLB1,ATF4,ATP5J,FBL,TP53,PPP1R1B,FLOT1,TPM3,ANXA2,ARHGDIB,HSPA8,CTSA,TMEM55A,CTSB,GAPDH,SQSTM1,FTH1,APOE,GJB6,NME1,SLC4A2,GBP1,DDIT3,FGF2,HEXA,PPIA,CD74,TMEFF1,MAL2,ADORA1,BCAP31,NFE2L2,ALDH5A1,SIGMAR1,TUBB4B,TRIB3,SNCG,PSMB6,CSTB,MYO5A,FOS,MT-ND1,NR4A2,NTRK3,PPT1,NR4A1,PSAP,TPP1,SOX9,ADRA1A,ATP2B1,MBP,HSPA5,CTSD,AK1,RHOG,MTMR2,TUBA1C,CNTNAP1,GAS5,MAPK8IP2,MT-TE,ARSA,FOSB,NDUFS3,TMEM176B,ETV5,RPSA,HSPB1,PEBP1,SUMO3,SCD,SLC1A4,ALAS1,NDUFA2,FARSB,ALDH2,PREPL,TIMP1,PPP1R2,ADCK3,ATP13A2,PSAT1,MT-ATP6,MT-ND6,CAPZB,SLC12A2,TUBG1,DNAJC1,SOD1,TSN,GIT1,ATP6V1E1,KCTD13,APLP2,CAPNS1,SLC14A1,TTL,TUBA1B,JMJD8,AHCYL1,TOR1A,RAN,HRAS,GHITM,CTSS,GAA,HADHB,PNKD,CHCHD2,TXN,ZBTB16,NAPA,POLR2I,CSRP2,TUBB2A,NINJ1,NGRN,CD68,NR1D1,MBD4,RTN4,MT-ND3,ITGA7,GSTP1,NDUFB2,RPS3A,SRD5A1,SLC1A3,KAZN,FKBP1A,UCHL1,CA3,JUN,GBA,LAMP1,RPL31,NDUFS4,MYL12A,EGR1,RPL17,MT-ND4,SLIRP,APP,FTL,PSME1,LAMP2,UQCR10,FKBP4,TSPO,CYCS,NCAM1,MT-TT,PFN1,KCND3,PFKFB1,MAP1B,ATP5L,SDC4,DYNLT1,LDHB,SLC25A6,COMT,CLCN3,PRKRA,SPP1,GPS2,SGCG,ATP6V1A,LMCD1,MAPT,RARRES3,MT-TP,SRM,COX7B,SDHB,LEP,EPB41L3,PKM,SMPD1,FAS,RPS4X,HMOX1,HINT1,PARK7,KCNMA1,PRNP,SCN2A,ADCY2,CD160,NDUFA13,MT-ND5,SLC1A2,ATP6V1B2	198	
Metabolic Disease	mitochondrial disorder	mitochondrial disorder	4.73E-14	 	 	 	 	MT-TT,NDUFA9,SFXN4,RRM2B,TYMP,MT-CO2,COA3,NDUFA1,NDUFA2,MT-TN,SDHAF1,SCO2,PCK2,FARS2,MT-CYB,COX14,MT-CO3,MT-ND2,NDUFS4,NDUFAF3,MT-CO1,MT-ND6,MT-ATP6,MPC1,MT-TY,MT-TQ,SURF1,MT-TC,MT-ND4,MT-TE,MT-ND4L,MRPS16,MT-ND5,MT-ND1,NDUFS8,NDUFA11,NDUFA12,MT-ND3,NDUFS3,UQCRQ,MT-TP,MT-TL1	42	
Connective Tissue Disorders, Inflammatory Disease, Skeletal and Muscular Disorders	rheumatic disease	Rheumatic Disease	5.60E-14	Increased	2.405	 	2.057	CRYAB,AGER,CTSG,CLSTN2,C1QA,CXCL9,SKIV2L,PTPRC,IP6K3,CCND3,AIF1,HIST1H2AC,TP53,CERS6,RBM38,LCP1,TNFRSF10B,FGFR2,IRF5,ARHGDIB,TMEM127,HSPA8,CTSA,SCUBE1,CTSB,FTH1,BANK1,APOE,GADD45B,DDIT3,FGF2,ADIPOQ,HLA-DQA1,HSPB8,CD74,TNXB,ALPK2,NFE2L2,FCGR3A/FCGR3B,CCR1,SIGMAR1,FCGR2A,TUBB4B,IGKC,ALOX5AP,ISG15,GRN,FOS,NR4A2,RPS16,NR4A1,ADRA1A,SOCS3,TLR8,HSPA5,CD28,RPS13,CXCL14,TUBA1C,PPP1CA,ADAMTS5,RPL32,PPP1R11,FOSB,SLC7A2,NAGLU,CAPN2,HTRA1,RPSA,IGFBP4,SLC1A4,MSR1,DNASE1L3,BARD1,TPGS2,IL17RA,HLA-G,CCSER2,RPL18A,EDN1,TIMP1,SAA1,STAT1,C14orf2,VCAM1,TUBG1,HPS1,NQO1,ATIC,SHB,CXCL16,APLP2,MAP4K4,EFEMP2,TMEM266,C9orf72,HLA-DQB1,C1QB,GSS,CXCL10,DYNLL1,CTSS,PIK3CG,PXK,ABCC1,CHCHD2,TXN,WNT5B,TUBB2A,CD68,CNTNAP4,IL10RA,MS4A7,GLUL,ALDOA,TCF7,C3AR1,ITGA7,FCGRT,ADAM17,MS4A6A,HLA-A,SLC1A3,FKBP1A,ST6GALNAC4,GPC4,SDC3,ASNS,LYZ,HLA-DRA,SLC19A1,FKBP5,RPL31,RPS24,MYL12A,TYROBP,TRIM28,PLA2G2A,ITGB2,FTL,FCER1G,TSPO,PER1,SLC7A11,ARF1,CD4,PRMT3,SDC4,TRIM31,LDHB,NRSN2,G0S2,CAMK2D,UQCC2,RPL19,NMNAT2,RFLNB,RET,TBC1D10C,MIF,SPP1,LMO4,RAC1,PHB2,RAB10,TPSAB1/TPSB2,SEL1L,IL1RN,FMN2,FPR3,LEP,ERN1,PRDX5,SLC7A1,CD83,RAMP2,FAS,NELFE,HMOX1,SLFN5,THBS1,ANXA1,TGFB2,KIT,S100A8,MAPKAPK2,ALPL,NLRC4,PRNP,ADAMTS15,SCN2A,VSIG4,F13A1,CSF1R,FAU,ENO1,DYM,SLC1A2,C6,HLTF,P2RX7	201	
Organismal Survival	organismal death	organismal death	5.81E-14	Decreased	-12.903	bias	 	CRYAB,TGFBR1,KDM6B,PCLO,AGER,PIK3R1,ASS1,RRM2B,CA5B,VAC14,C1QA,SLC35C1,CXCL9,SLC9A1,SPRY4,GNB1,PTPRC,POR,GATAD2A,CCND3,ARID3B,ATG9A,KEAP1,ATF4,PLXNB2,STAM,MGAT1,UNG,TP53,FBL,RBM38,LCP1,UXS1,RHEB,MTSS1,SURF1,FGFR2,TPM3,IRF5,ARHGDIB,HAX1,NRBP1,CTSA,NPR3,CTSB,ATOX1,NHLH1,SQSTM1,ACTG1,DEAF1,ESR2,FTH1,APOE,GJB6,SLC4A2,FGF2,HS2ST1,GDF15,HSPB8,ADIPOQ,PPIA,HEXA,COPS8,CD74,PTPRJ,TNXB,ATP5J2,DAB2,ASPH,GNG5,ADORA1,SCNN1B,NFE2L2,AMOT,ALDH5A1,CCR1,RPL4,UCP2,GNA12,MESP1,DGAT2,ENG,ISG15,GRN,FOS,KIF7,NR4A2,NTRK3,FLNC,RSPO1,PPT1,DERL1,MBD3,TPP1,PSAP,ARHGDIA,SOX9,BMPER,SIM1,ADRA1A,PRKACB,ABCB6,ICMT,SOCS3,DCUN1D5,DAD1,TRAF3,AKR1C3,ATP2B1,ABCA3,CSNK1A1,TYMP,HSPA5,INTS1,BIN1,CEBPG,CD28,CTSD,HS6ST1,ZNRF3,EIF3D,CXCL14,HOXA7,STAB1,MTMR2,CNTNAP1,GCLM,TOP3B,PFKFB3,STXBP1,IL2RG,UROS,PCSK6,MAPK8IP2,ASNA1,HNRNPAB,UBA6,CITED1,KLF4,TXNRD1,SLC3A2,AES,SPINK5,ADAM12,RBX1,COMMD1,NAGLU,CAPN2,H1F0,INSR,MEGF8,UBE2I,CD151,RPSA,ATP6V0C,SUMO3,F2RL3,MSR1,NELFB,BARD1,DMD,PDGFC,HNRNPK,IRAK1,CIAPIN1,HLA-G,SLC19A3,EDN1,TIMP1,CFH,STAT1,PSMG1,KRT14,VCAM1,CAPZB,SLC9A3R1,TRIM55,SLC12A2,TUBG1,DVL1,NQO1,G6PD,CSRNP1,SOD1,SNX27,KIF3B,GIT1,CISD2,NFE2L1,SHB,APLP2,CAPNS1,PCCA,LGALS2,SLC14A1,KIF5B,TTL,FECH,EFEMP2,MAP4K4,APOB,ITSN1,TOR1A,MAF,ITGA8,HRAS,NCSTN,MKI67,KPNA1,GSS,APRT,CXCL10,SGPL1,PEG10,ABR,ABCC1,PIK3CG,TXN,HMBS,WNT5B,RFNG,CFL1,CPA3,NINJ1,MNT,CCND2,CD68,PIP5K1C,STIP1,RTN4,ARHGAP35,B3GNT5,SFRP1,CYR61,ITGA7,C3AR1,LCP2,GSTP1,HIST1H1C,ADAM17,TCEA1,HYOU1,SLC1A3,FKBP1A,ATP6AP1,H2AFZ,ENAH,MAFG,LYZ,JUN,GBA,TOP2A,LAMP1,SLC19A1,NACC1,STIM1,PI4KA,GJB2,PLOD3,NDUFS4,MBOAT7,RPS19,KRT6B,TRIM28,CSRNP2,SLIRP,KRT5,COPS3,PLA2G2A,POMGNT1,AIP,APP,ITGB2,LAMP2,SUPV3L1,GLIS2,SOX6,SREBF2,SBF1,USP22,FCER1G,PEA15,PRMT5,FKBP4,NR5A2,CYCS,DVL3,CBX4,GABARAP,NCAM1,PNO1,PFN1,SLC31A1,UBE2A,ARF1,CD4,MAP1B,SDC4,TAF10,CTBP1,RSPO3,CFL2,CYBB,ITGAV,SLC7A5,ANXA7,SIAH2,C1QBP,RET,CLCN3,PTX3,SHOC2,EIF2AK1,PRKRA,MIF,SPP1,SGCG,LMO4,PSMC4,RAC1,PHB2,ADCYAP1R1,ACKR3,IL1RN,MAPK10,CNPY3,CD14,CLCN7,GNL3,LFNG,VDAC1,SPRED1,LEP,EPB41L3,ERN1,NLGN1,PDGFA,PKM,SLC7A1,SMPD1,HIF1A,RAMP2,FAS,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,S100A8,SLC40A1,MAPKAPK2,ALPL,STK40,CTDNEP1,RAB8B,PRNP,PSMB4,SCN2A,COX17,COL5A2,F13A1,VSIG4,MAPK9,KIFAP3,CSF1R,SLC5A3,PLXND1,NDUFA13,TRPM6,KIF2A,CLDN1,EPHB3,SLC1A2,PANK3,GBE1,HLTF,CARM1,SHMT2	381	
Dermatological Diseases and Conditions	psoriasis	psoriasis	5.85E-14	 	 	 	 	CSTA,TGFBR1,AGER,RAN,GARS,MKI67,CXCL9,ODC1,POR,CXCL10,SCO2,PTPRC,CCND3,CTSS,ABCC1,KEAP1,ZBTB16,CFL1,FGFR2,ANXA2,DSG1,HAX1,ARHGDIB,HSPA8,CCND2,CTSB,GAPDH,ATOX1,C3AR1,GSTP1,EPHX1,S100A11,APOE,ADAM17,GBP1,ARPC1B,PSMB10,CRAT,FKBP1A,H2AFZ,LAMP3,KRTDAP,S100A7,JUN,GBA,TNXB,PGAM1,UBE2K,KRT10,FCGR3A/FCGR3B,GJB2,KRT6B,EGR1,SLC39A6,KRT5,PSMB6,CSTB,ISG15,PI3,ITGB2,FOS,NR4A2,KRT6A,PSAP,CYCS,ARHGDIA,CD4,MBP,TYMP,TAF10,ZNF91,TUBB,HSPA5,CD63,PGD,G0S2,CYP3A5,ALDH3A2,IFI30,CCT5,KPNA2,GOT1,SEC61B,MUCL1,C1QBP,PSMA6,MIF,GM2A,EIF2S2,PKN1,ADAM12,IL1RN,EIF5A,CST6,VDAC1,CBX3,UBE2I,SRM,CD2,PKM,HIF1A,ME1,IL17RA,IRAK1,HLA-G,HMOX1,ANXA1,PSMA3,S100A8,STAT1,KRT14,VCAM1,HSPH1,TUBG1,F13A1,PDLIM4,IL20RB,S100A2,THRSP,APOC1,SLC25A5,P2RX7	122	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial encephalomyopathy	mitochondrial encephalomyopathy	7.44E-14	 	 	 	 	MT-TT,NDUFA9,RRM2B,TYMP,NDUFA2,SCO2,MT-CYB,MT-CO3,MT-ND2,NDUFS4,MT-ATP6,MT-ND6,MT-TY,MT-TQ,SURF1,MT-ND4,MT-TC,MT-ND1,MT-ND5,NDUFS8,NDUFA12,MT-ND3,NDUFS3,MT-TP,MT-TL1	25	
Organismal Survival	morbidity or mortality	morbidity or mortality	1.07E-13	Decreased	-12.809	bias	 	CRYAB,TGFBR1,KDM6B,PCLO,AGER,PIK3R1,ASS1,RRM2B,CA5B,VAC14,CTSG,C1QA,SLC35C1,CXCL9,SLC9A1,SPRY4,GNB1,PTPRC,POR,GATAD2A,CCND3,ARID3B,ATG9A,KEAP1,ATF4,PLXNB2,STAM,MGAT1,UNG,TP53,FBL,RBM38,LCP1,UXS1,RHEB,MTSS1,SURF1,FGFR2,TPM3,IRF5,ARHGDIB,HAX1,NRBP1,CTSA,NPR3,CTSB,ATOX1,NHLH1,SQSTM1,ACTG1,DEAF1,ESR2,FTH1,APOE,GJB6,SLC4A2,FGF2,HS2ST1,GDF15,HSPB8,ADIPOQ,PPIA,HEXA,COPS8,CD74,PTPRJ,TNXB,ATP5J2,DAB2,ASPH,GNG5,ADORA1,SCNN1B,NFE2L2,AMOT,ALDH5A1,CCR1,RPL4,UCP2,GNA12,MESP1,DGAT2,ENG,ISG15,GRN,FOS,KIF7,NR4A2,NTRK3,FLNC,RSPO1,PPT1,DERL1,MBD3,TPP1,PSAP,ARHGDIA,SOX9,BMPER,SIM1,ADRA1A,PRKACB,ABCB6,ICMT,SOCS3,DCUN1D5,DAD1,TRAF3,AKR1C3,ATP2B1,ABCA3,CSNK1A1,TYMP,HSPA5,INTS1,BIN1,CEBPG,CD28,CTSD,HS6ST1,ZNRF3,EIF3D,CXCL14,HOXA7,STAB1,MTMR2,CNTNAP1,GCLM,TOP3B,PFKFB3,STXBP1,IL2RG,UROS,PCSK6,MAPK8IP2,ASNA1,HNRNPAB,UBA6,CITED1,KLF4,TXNRD1,SLC3A2,AES,SPINK5,ADAM12,RBX1,COMMD1,NAGLU,CAPN2,H1F0,INSR,MEGF8,UBE2I,CD151,RPSA,ATP6V0C,SUMO3,F2RL3,MSR1,NELFB,BARD1,DMD,PDGFC,HNRNPK,IRAK1,CIAPIN1,HLA-G,SLC19A3,EDN1,TIMP1,CFH,STAT1,PSMG1,KRT14,VCAM1,CAPZB,SLC9A3R1,TRIM55,NPY1R,SLC12A2,TUBG1,DVL1,NQO1,G6PD,CSRNP1,SOD1,SNX27,KIF3B,GIT1,CISD2,NFE2L1,SHB,APLP2,CAPNS1,PCCA,LGALS2,SLC14A1,KIF5B,TTL,FECH,EFEMP2,MAP4K4,APOB,ITSN1,TOR1A,MAF,ITGA8,HRAS,NCSTN,MKI67,KPNA1,GSS,APRT,CXCL10,SGPL1,PEG10,ABR,ABCC1,PIK3CG,TXN,HMBS,WNT5B,RFNG,CFL1,CPA3,NINJ1,MNT,CCND2,CD68,PIP5K1C,STIP1,RTN4,ARHGAP35,B3GNT5,SFRP1,CYR61,ITGA7,C3AR1,LCP2,GSTP1,HIST1H1C,ADAM17,TCEA1,HLA-A,HYOU1,SLC1A3,FKBP1A,ATP6AP1,H2AFZ,ENAH,MAFG,LYZ,JUN,GBA,TOP2A,LAMP1,SLC19A1,NACC1,STIM1,PI4KA,GJB2,PLOD3,NDUFS4,MBOAT7,RPS19,KRT6B,TRIM28,CSRNP2,SLIRP,KRT5,COPS3,PLA2G2A,POMGNT1,AIP,APP,ITGB2,LAMP2,SUPV3L1,GLIS2,SOX6,SREBF2,SBF1,USP22,FCER1G,PEA15,PRMT5,FKBP4,NR5A2,CYCS,DVL3,CBX4,GABARAP,NCAM1,PNO1,PFN1,SLC31A1,UBE2A,ARF1,CD4,MAP1B,SDC4,TAF10,CTBP1,RSPO3,CFL2,CYBB,ITGAV,SLC7A5,ANXA7,SIAH2,C1QBP,RET,CLCN3,PTX3,SHOC2,EIF2AK1,PRKRA,MIF,SPP1,SGCG,LMO4,PSMC4,RAC1,PHB2,ADCYAP1R1,ACKR3,IL1RN,MAPK10,CNPY3,CD14,CLCN7,GNL3,LFNG,VDAC1,SPRED1,LEP,EPB41L3,ERN1,NLGN1,PDGFA,PKM,SLC7A1,SMPD1,HIF1A,RAMP2,FAS,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,VCP,TGFB2,KIT,S100A8,SLC40A1,MAPKAPK2,ALPL,STK40,CTDNEP1,RAB8B,PRNP,PSMB4,SCN2A,COX17,COL5A2,F13A1,VSIG4,MAPK9,KIFAP3,CSF1R,SLC5A3,PLXND1,NDUFA13,TRPM6,KIF2A,CLDN1,EPHB3,SLC1A2,PANK3,GBE1,HLTF,CARM1,SHMT2	384	
Metabolic Disease, Neurological Disease, Skeletal and Muscular Disorders	mitochondrial leukoencephalopathy	mitochondrial leukoencephalopathy	1.08E-13	 	 	 	 	MT-ND6,MT-ATP6,NDUFA9,MT-TY,MT-TQ,RRM2B,SURF1,MT-TC,MT-ND4,TYMP,NDUFA2,SCO2,MT-ND5,MT-ND1,NDUFS8,NDUFA12,MT-CO3,MT-ND3,NDUFS3,MT-ND2,NDUFS4,MT-TL1	22	
Inflammatory Response	inflammatory response	inflammatory response	2.69E-13	Increased	3.990	 	1.422	AGER,MAF,CTSG,CXCL9,SLC9A1,PTPRC,CXCL10,CTSS,ABR,PXK,ABCC1,PIK3CG,TXN,AIF1,TMSB10/TMSB4X,ZBTB16,TP53,HNRNPA0,CERS6,LCP1,FLOT1,ANXA2,NINJ1,SPON2,PLAA,NR1D1,YARS,PIP5K1C,IL10RA,CTSB,SFRP1,C3AR1,APOE,ADAM17,GJB6,DDIT3,DAPK2,SLC1A5,FGF2,HLA-A,ADIPOQ,LGALS9,PPIA,FKBP1A,CD74,S100A7,LYZ,PTPRJ,CCL28,PLIN2,STIM1,ADORA1,HCAR2,NFE2L2,CCR1,RPS19,TYROBP,FCGR2A,EGR1,GNA12,ALOX5AP,ENG,NRROS,PLA2G2A,APP,ISG15,GRN,FOS,ITGB2,MT-ND1,NR4A2,TREM2,PPT1,FCER1G,MS4A2,AOX1,CYP4F11,SOCS3,TRAF3,PFN1,CD4,TLR8,SDC4,CD63,CD28,CXCL14,ITGAV,NUPR1,CYBB,C1QBP,TOP3B,EIF2AK1,PTX3,MIF,SPP1,STK39,RAC1,CAPG,KLF4,CMC2,TPSAB1/TPSB2,OSTM1,EFS,PREX1,ACKR3,IL1RN,MAPT,SLC7A2,CD14,CLCN7,PIK3AP1,SIRPA,HSPB1,CD151,LITAF,LEP,TOLLIP,MSR1,PRDX5,ERN1,IL17RA,IRAK1,TNFRSF12A,HLA-G,HMOX1,PARK7,EDN1,THBS1,ANXA1,DUSP10,SAA1,TGFB2,KIT,S100A8,CFH,STAT1,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NPY1R,MAPK9,SOD1,GIT1,CSF1R,NFE2L1,FGF1,CXCL16,C6,NCKAP1L,P2RX7	152	
Immunological Disease	hypersensitive reaction	hypersensitive reaction	2.76E-13	Increased	2.834	 	1.535	PER1,GAB2,PLIN1,TGFBR1,AGER,CD4,MBP,GARS,FCER1A,MKI67,STARD7,CXCL9,CD63,PTPRC,CXCL10,CD28,LGMN,ALDH3A2,PIK3CG,IFI30,MUCL1,NAPA,CBR1,TP53,MIF,TRIOBP,SPP1,CFL1,MAD2L2,CPVL,TPM3,FLOT1,CAPG,BRF2,MNT,MYL9,SPINK5,IL1RN,ALCAM,CST6,C3AR1,LCP2,UBE2I,S100A11,APOE,SRM,ADAM17,LAPTM5,CD2,HLA-A,HLA-DQA1,ADIPOQ,PPIA,FKBP1A,SMPD1,CD83,CD74,H2AFZ,S100A7,JUN,TIMP1,FLNA,ANXA1,DUSP10,ANXA5,VCP,HLA-DRA,KIT,STIM1,S100A8,CFH,STAT1,KRT10,P4HA2,CCR1,CAPZB,FCGR2A,NPY1R,IGKC,ALOX5AP,KRT5,SOD1,S100A2,IL20RB,ITGB2,PI3,ENO1,NR4A2,LGALS2,FCER1G,FKBP4,MS4A2,KRT6A,PSAP,ADRA1A	95	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	mitochondrial respiratory chain deficiency	mitochondrial respiratory chain deficiency	6.06E-13	 	 	 	 	NDUFA9,MT-CO2,NDUFA1,COA3,NDUFA2,MT-TN,SDHAF1,COX14,MT-CO3,MT-ND2,NDUFAF3,NDUFS4,MT-CO1,MT-ND6,SURF1,MT-ND4,MT-TE,MT-ND1,MT-ND5,NDUFS8,NDUFA11,NDUFA12,MT-ND3,NDUFS3,UQCRQ,MT-TL1	26	
Free Radical Scavenging	metabolism	metabolism of reactive oxygen species	6.96E-13	Increased	2.151	 	0.332	CRYAB,AGER,ITSN1,PIK3R1,CTSG,HRAS,TMBIM6,CXCL9,SCO2,PIK3CG,ABCC1,TXN,TP53,CD52,ARHGDIB,PRELID1,RTN4,SQSTM1,CYR61,ESR2,C3AR1,GSTP1,LCP2,FTH1,APOE,DDIT3,UBQLN1,FGF2,ADIPOQ,PPIA,RPL26,TPO,NFE2L2,FCGR3A/FCGR3B,SIGMAR1,LETM1,UCP2,FCGR2A,TYROBP,NRROS,CSTB,APP,GRN,ITGB2,FOS,FTL,SREBF2,NR4A1,CYCS,ARHGDIA,GABARAP,GAB2,SOCS3,TRAF3,PLCB2,TLR8,FCER1A,CD28,ALDH3A2,CXCL14,CYBB,CLCN3,MT-ND2,CBR1,HK1,MIF,SPP1,HSPA9,RPL29,RAC1,SDHC,ARSA,TXNRD1,PREX1,MAPT,CD14,INSR,AKR1B1,VDAC1,HSPB1,PTGFR,LEP,MSR1,PRDX5,SMPD1,FAS,HNRNPK,IRAK1,ALDH2,HMOX1,EDN1,PARK7,ANXA1,CYGB,S100A8,CFH,LONP1,NLRC4,PRNP,MT-CO1,MT-ND6,VCAM1,NQO1,G6PD,SOD1,P2RX7	106	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of granulocytes	7.03E-13	Increased	2.587	bias	-0.071	SOCS3,PLCB2,CRYAB,AGER,CMA1,PIK3R1,UNC5B,CTSG,CXCL9,CXCL10,CD28,RSPO3,PIK3CG,CXCL14,CYBB,NEO1,TXN,C1QBP,TMSB10/TMSB4X,TP53,PTX3,SPP1,RAC1,FLOT1,CAPG,TPSAB1/TPSB2,SPON2,PREX1,PIP5K1C,IL1RN,YARS,RTN4,CTSB,CD14,SFRP1,PLTP,C3AR1,SIRPA,HSPB1,CD151,APOE,ADAM17,LEP,MSR1,CD2,DAPK2,GDF15,ADIPOQ,LGALS9,PPIA,HIF1A,CD74,IL17RA,FAS,S100A7,HMOX1,EDN1,TIMP1,ANXA1,CCL28,SAA1,TGFB2,S100A8,STIM1,CFH,ADORA1,MAPKAPK2,NFE2L2,GJB2,CCR1,RPS19,THBS4,VCAM1,FCGR2A,NQO1,ALOX5AP,MAPK9,ENG,APP,GRN,ITGB2,MT-ND1,FCER1G,NR4A1,NCKAP1L	85	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Leber's optic atrophy	Leber's optic atrophy	7.48E-13	 	 	 	 	MT-CO1,MT-ND6,MT-ND5,MT-ATP6,MT-ND1,MT-CYB,MT-CO3,MT-ND4,MT-ND3,MT-ND2,MT-ND4L	11	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of leukocytes	9.01E-13	Increased	3.983	bias	0.753	CRYAB,TGFBR1,AGER,PIK3R1,CTSG,HRAS,CXCL9,CHST2,CXCL10,PTPRC,SGPL1,CTSS,ABCC1,PIK3CG,TXN,AIF1,TMSB10/TMSB4X,ZBTB16,TP53,LCP1,FLOT1,ANXA2,NINJ1,SPON2,YARS,PIP5K1C,MS4A4A,IL10RA,RTN4,CTSB,ALCAM,PLTP,SFRP1,CYR61,ESR2,C3AR1,LCP2,RAP2A,APOE,ADAM17,DAPK2,HLA-A,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,CD74,S100A7,CES1,JUN,GBA,PTPRJ,CCL28,STIM1,ADORA1,HCAR2,NFE2L2,KRT10,GJB2,FCGR3A/FCGR3B,CCR1,RPS19,CD209,UCP2,TYROBP,FCGR2A,GNA12,ALOX5AP,ENG,APP,GRN,FOS,ITGB2,MT-ND1,GLIS2,TREM2,FCER1G,NR4A1,SOCS3,PLCB2,PFN1,CMA1,CD4,UNC5B,FCER1A,CD63,CD28,RSPO3,NARS,CXCL14,ITGAV,CYBB,NEO1,STAB1,C1QBP,PTX3,MIF,SPP1,RAC1,CAPG,FYB,TPSAB1/TPSB2,EFS,PREX1,ACKR3,IL1RN,SH2B3,MAPK10,CD14,SIRPA,HSPB1,CD151,LITAF,LEP,MSR1,CD2,SMPD1,HIF1A,IL17RA,FAS,HLA-G,HMOX1,EDN1,TIMP1,THBS1,FLNA,ANXA1,DUSP10,SAA1,TGFB2,KIT,S100A8,CFH,STAT1,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NQO1,TRPA1,MAPK9,PLXND1,GIT1,CSF1R,CXCL16,C6,NCKAP1L,P2RX7	150	
Cellular Movement	cell movement	cell movement of blood cells	9.14E-13	Increased	4.484	bias	0.979	CRYAB,TGFBR1,APOB,KDM6B,AGER,PIK3R1,CTSG,HRAS,CXCL9,CHST2,PTPRC,CXCL10,SGPL1,CTSS,ABCC1,PIK3CG,TXN,AIF1,TMSB10/TMSB4X,ZBTB16,TP53,LCP1,FLOT1,ANXA2,IRF5,NINJ1,SPON2,PIP5K1C,YARS,MS4A4A,IL10RA,RTN4,CTSB,ALCAM,SFRP1,PLTP,CYR61,C3AR1,ESR2,LCP2,APOE,RAP2A,ADAM17,DAPK2,FGF2,HLA-A,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,CD74,S100A7,LYZ,CES1,JUN,GBA,PTPRJ,CCL28,ANXA5,STIM1,ADORA1,HCAR2,NFE2L2,KRT10,GJB2,FCGR3A/FCGR3B,CCR1,RPS19,CD209,UCP2,TYROBP,FCGR2A,EGR1,GNA12,ALOX5AP,ENG,APP,GRN,FOS,ITGB2,MT-ND1,GLIS2,TREM2,FCER1G,NR4A1,GAB2,PER1,SOCS3,PLCB2,PFN1,CMA1,CD4,UNC5B,FCER1A,CD63,CD28,NARS,RSPO3,CXCL14,CYBB,ITGAV,HOXA7,NEO1,STAB1,C1QBP,PTX3,MIF,SPP1,RAC1,CAPG,FYB,TPSAB1/TPSB2,EFS,PREX1,ACKR3,IL1RN,SH2B3,MAPK10,CD14,AKR1B1,SIRPA,HSPB1,CD151,LITAF,LEP,MSR1,CD2,PLGRKT,SMPD1,HIF1A,IL17RA,FAS,HLA-G,HMOX1,EDN1,TIMP1,THBS1,FLNA,ANXA1,DUSP10,SAA1,TGFB2,KIT,S100A8,CFH,STAT1,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NQO1,ST3GAL6,TRPA1,MAPK9,F13A1,SOD1,PLXND1,GIT1,CSF1R,FGF1,CXCL16,C6,NCKAP1L,P2RX7	166	
Dermatological Diseases and Conditions, Immunological Disease, Inflammatory Disease	lichen planus	lichen planus	9.89E-13	 	 	 	 	APOE,ATP5G1,LAPTM5,PFN1,HLA-A,FOLR2,FKBP1A,TYMP,CD74,HLA-DQB1,CXCL9,S100A7,DYNLL1,JUN,ABCC1,HLA-DRA,IFI30,MUCL1,CALML3,RNPEPL1,LCP1,CFL1,SYNGR2,KRT5,PLXND1,CD52,S100A2,GRN,ENO1,KRT6A,EIF5A,RAMP3,FTH1	33	
Cellular Movement, Immune Cell Trafficking	migration	leukocyte migration	1.27E-12	Increased	4.463	bias	0.983	CRYAB,TGFBR1,APOB,KDM6B,AGER,PIK3R1,CTSG,HRAS,CXCL9,CHST2,PTPRC,CXCL10,SGPL1,CTSS,ABCC1,PIK3CG,TXN,AIF1,TMSB10/TMSB4X,ZBTB16,TP53,LCP1,FLOT1,ANXA2,IRF5,NINJ1,SPON2,PIP5K1C,YARS,MS4A4A,IL10RA,RTN4,CTSB,ALCAM,SFRP1,PLTP,CYR61,C3AR1,ESR2,LCP2,APOE,RAP2A,ADAM17,DAPK2,FGF2,HLA-A,GDF15,HYOU1,ADIPOQ,LGALS9,PPIA,CD74,S100A7,LYZ,CES1,JUN,GBA,PTPRJ,CCL28,ANXA5,STIM1,ADORA1,HCAR2,NFE2L2,KRT10,GJB2,FCGR3A/FCGR3B,CCR1,RPS19,CD209,UCP2,TYROBP,FCGR2A,EGR1,GNA12,ALOX5AP,ENG,APP,GRN,FOS,ITGB2,MT-ND1,GLIS2,TREM2,FCER1G,NR4A1,GAB2,PER1,SOCS3,PLCB2,PFN1,CMA1,CD4,UNC5B,FCER1A,CD63,CD28,NARS,RSPO3,CXCL14,CYBB,ITGAV,HOXA7,NEO1,STAB1,C1QBP,PTX3,MIF,SPP1,RAC1,CAPG,FYB,TPSAB1/TPSB2,EFS,PREX1,ACKR3,IL1RN,SH2B3,MAPK10,CD14,SIRPA,HSPB1,CD151,LITAF,LEP,MSR1,CD2,PLGRKT,SMPD1,HIF1A,IL17RA,FAS,HLA-G,HMOX1,EDN1,TIMP1,THBS1,FLNA,ANXA1,DUSP10,SAA1,TGFB2,KIT,S100A8,CFH,STAT1,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NQO1,ST3GAL6,TRPA1,MAPK9,F13A1,SOD1,PLXND1,GIT1,CSF1R,FGF1,CXCL16,C6,NCKAP1L,P2RX7	165	
Cellular Movement	cellular infiltration	cellular infiltration	1.48E-12	 	1.203	 	0.383	SOCS3,PLCB2,CRYAB,TGFBR1,AGER,CMA1,PIK3R1,CD4,MBP,UNC5B,FCER1A,CTSG,HRAS,CXCL9,HSPA5,TUBB,CXCL10,CD28,RSPO3,CTSS,PIK3CG,CYBB,ZBTB16,TP53,PTX3,MIF,SPP1,HNRNPAB,NINJ1,EFS,PREX1,IL1RN,CTSB,GAPDH,ALDOA,CD14,SFRP1,PLTP,CYR61,AKR1B1,C3AR1,ESR2,LCP2,HSPB1,APOE,ADAM17,LEP,MSR1,GBP1,CD2,FGF2,PDGFA,HLA-A,HYOU1,ADIPOQ,PPIA,DMD,HIF1A,IL17RA,FAS,HMOX1,ALDH2,CES1,JUN,GBA,EDN1,TIMP1,THBS1,ANXA1,DUSP10,SAA1,S100A8,STIM1,CFH,MAPKAPK2,STAT1,NFE2L2,KRT10,GJB2,CCR1,VCAM1,UCP2,NQO1,TRPA1,ALOX5AP,ENG,CSF1R,APP,CXCL16,ITGB2,ENO1,GLIS2,FCER1G,NR4A1,C6,P2RX7	96	
Free Radical Scavenging	synthesis	synthesis of reactive oxygen species	3.25E-12	 	1.751	 	0.086	CRYAB,AGER,ITSN1,PIK3R1,CTSG,HRAS,TMBIM6,CXCL9,SCO2,PIK3CG,ABCC1,TP53,CD52,ARHGDIB,PRELID1,RTN4,SQSTM1,CYR61,ESR2,C3AR1,GSTP1,LCP2,FTH1,APOE,DDIT3,UBQLN1,FGF2,ADIPOQ,PPIA,RPL26,TPO,NFE2L2,FCGR3A/FCGR3B,SIGMAR1,LETM1,UCP2,FCGR2A,TYROBP,CSTB,APP,GRN,ITGB2,FOS,FTL,SREBF2,NR4A1,ARHGDIA,GABARAP,SOCS3,GAB2,TRAF3,PLCB2,FCER1A,TLR8,CD28,ALDH3A2,CXCL14,CYBB,CLCN3,MT-ND2,CBR1,HK1,MIF,SPP1,HSPA9,RAC1,RPL29,SDHC,ARSA,TXNRD1,PREX1,MAPT,CD14,INSR,AKR1B1,VDAC1,HSPB1,PTGFR,LEP,MSR1,SMPD1,FAS,HNRNPK,IRAK1,ALDH2,HMOX1,EDN1,PARK7,ANXA1,S100A8,CFH,LONP1,NLRC4,PRNP,MT-CO1,MT-ND6,VCAM1,NQO1,G6PD,SOD1,P2RX7	101	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	rheumatoid arthritis	rheumatoid arthritis	3.66E-12	 	0.528	 	0.248	TMEM266,C9orf72,AGER,CTSG,C1QA,CLSTN2,HLA-DQB1,CXCL9,CXCL10,SKIV2L,PTPRC,DYNLL1,IP6K3,PIK3CG,CHCHD2,TXN,AIF1,HIST1H2AC,TP53,CERS6,RBM38,LCP1,TNFRSF10B,IRF5,ARHGDIB,HSPA8,TMEM127,CD68,CNTNAP4,IL10RA,MS4A7,CTSB,ALDOA,GLUL,C3AR1,FTH1,FCGRT,APOE,GADD45B,MS4A6A,HLA-A,FGF2,HLA-DQA1,ADIPOQ,HSPB8,FKBP1A,ST6GALNAC4,GPC4,SDC3,CD74,LYZ,TNXB,HLA-DRA,SLC19A1,ALPK2,FKBP5,RPL31,FCGR3A/FCGR3B,MYL12A,RPS24,CCR1,FCGR2A,IGKC,TRIM28,PLA2G2A,GRN,FOS,ITGB2,NR4A2,RPS16,NR4A1,TSPO,SOCS3,SLC7A11,ARF1,PRMT3,CD4,SDC4,TRIM31,LDHB,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,RPL19,RFLNB,RPL32,MIF,SPP1,LMO4,RAB10,PPP1R11,FOSB,SEL1L,IL1RN,FMN2,SLC7A2,NAGLU,RPSA,IGFBP4,PRDX5,TPGS2,SLC7A1,CD83,IL17RA,RAMP2,NELFE,HLA-G,HMOX1,SLFN5,RPL18A,CCSER2,TIMP1,THBS1,ANXA1,SAA1,TGFB2,S100A8,STAT1,ALPL,PRNP,VCAM1,VSIG4,ATIC,FAU,CXCL16,ENO1,APLP2,DYM,SLC1A2,MAP4K4	134	
Dermatological Diseases and Conditions	psoriasis	chronic psoriasis	4.10E-12	 	 	 	 	S100A11,SRM,APOE,AGER,CD2,PSMB10,PKM,GARS,HIF1A,TAF10,ME1,H2AFZ,IRAK1,S100A7,POR,HMOX1,PGD,TNXB,PGAM1,ALDH3A2,CCT5,KPNA2,GOT1,C1QBP,STAT1,GJB2,HSPH1,TUBG1,SLC39A6,S100A2,EIF2S2,CSTB,HSPA8,PI3,CTSB,ATOX1,EIF5A,SLC25A5,CST6,GSTP1,UBE2I	41	
Molecular Transport	transport	transport of molecule	4.83E-12	Increased	3.204	bias	-0.889	CRYAB,AGER,C1QTNF5,PIK3R1,CTSG,PANX1,SLC9A1,PTPRC,FRAS1,MYBBP1A,SLCO2B1,TP53,SLC2A5,ANXA2,RHBDD1,SLC38A3,HSPA8,SLC7A10,CTSA,NPR3,ATOX1,SQSTM1,PLTP,SVBP,ESR2,STEAP3,FTH1,EPHX1,APOE,FHL1,SLC4A2,SLC1A5,FGF2,CUBN,GDF15,ADIPOQ,PPIA,CRAT,CD74,SLC35B2,SORBS1,PEX10,PLIN2,BCAP31,SCNN1B,ADORA1,HCAR2,NFE2L2,CCR1,FCGR2A,SLC39A6,SLC25A1,IPO7,TRIB3,SNCG,MYO5A,RSPO1,PPT1,NR4A1,PSAP,BMPER,TTYH3,ABCC3,ABCB6,SOCS3,TRAF3,YWHAH,AKR1C3,SESN2,ATP2B1,SCAMP2,ABCA3,MBP,MCUR1,FCER1A,NME2,AP1B1,HSPA5,CD28,AK1,CHMP1A,STXBP1,STK39,TNPO1,GM2A,ASNA1,CITED1,SLC3A2,FOSB,KCNG1,SLC7A2,COMMD1,INSR,SIRPA,UBE2I,ATP6V0C,SCD,SLC1A4,MSR1,SLC38A1,IRAK1,SLC19A3,EDN1,FYTTD1,SAA1,CFH,STAT1,AKR1C1/AKR1C2,SLC9A3R1,NPY1R,SLC12A2,DVL1,SNTB1,TRPA1,DNAJC1,SOD1,SNX27,FGF1,ATP6V1E1,CISD1,CIDEA,GIPR,APLP2,SLC14A1,KIF5B,FECH,SLC25A5,MAP4K4,SLC29A4,APOB,AHCYL1,RAN,HRAS,KPNA1,SNX12,CXCL10,SCYL2,CTSS,ABCC1,PXK,PNKD,NAPA,SFRP4,CFL1,SLC24A3,STOML2,HMGA1,SYTL1,SERINC2,SLC25A22,PRELID1,RTN4,GLUL,RAMP3,C3AR1,LCP2,SLC24A2,ATP6V0B,HLA-A,CDK16,SLC1A3,XPOT,FOLR2,ATP6AP1,SLBP,CES1,JUN,MT-CYB,SLC19A1,STIM1,GJB2,SLC7A6,LETM1,EGR1,STXBP6,APP,FTL,SLC48A1,FCER1G,PEA15,FKBP4,MS4A2,TSPO,NR5A2,P2RY12,GABARAP,SCAMP3,NPC2,ACTR1A,PER1,PLCB2,SLC31A1,SLC7A11,ATP5D,KCND3,ARF1,CD4,MAP1B,LHCGR,XPO5,ATP5L,DYNLT1,CAMK2D,ITGAV,NEO1,SLC7A5,KPNA2,SEC61B,RILP,RET,CLCN3,VPS11,HK1,EIF2AK1,MIF,ACSL3,HSPA9,PHB2,RAC1,RAB10,SLC39A3,ATP6V1A,PKN1,SEL1L,ERP29,IL1RN,MAPT,FMN2,CD14,CLCN7,EIF5A,VDAC1,XPO6,ARL2,SPIRE1,LEP,VAPA,PKM,SLC30A2,SLC7A1,SMPD1,HIF1A,RAMP2,FAS,CLCN4,HMOX1,THBS1,KCNMA1,ANXA1,TGFB2,SLC40A1,S100A8,CHCHD4,PRNP,SCN2A,AP3D1,RAB7A,MAPK9,KCNJ3,SLC5A3,KCNQ4,ANO2,TRPM6,APOC1,SLC1A2,VAMP8,CPEB1,P2RX7,ATP6V1B2	269	
Cell Death and Survival	apoptosis	apoptosis of tumor cell lines	5.67E-12	Decreased	-3.121	 	-2.582	CSTA,CRYAB,WHSC1,TGFBR1,AGER,CTSG,TMBIM6,SLC9A1,ODC1,PTPRC,ARID3B,CCND3,ATF4,MYBBP1A,TMSB10/TMSB4X,TP53,CERS6,LAIR1,PPP1R1B,TNFRSF10B,FGFR2,ANXA2,IRF5,DSG1,HAX1,HSPA8,BTG2,CTSB,ALCAM,GAPDH,DUSP4,SQSTM1,LYPLA1,ESR2,FTH1,APOE,NME1,NACC2,GADD45B,DDIT3,OSGIN1,FGF2,DAPK2,GDF15,ADIPOQ,HSPB8,LGALS9,PPIA,GLIPR1,OGT,RABL6,DAB2,ADORA1,HCAR2,NFE2L2,SLC39A6,ENG,GRN,FOS,NR4A2,NTRK3,NR4A1,PSAP,ARHGDIA,SOX9,SOCS3,CCT2,FCER1A,CSNK1A1,OGFOD1,TYMP,RNASE1,HSPA5,CD28,HSPA4,CTSD,SAE1,ENTPD5,PACS2,NUPR1,HOXA7,PPP1CA,PTPRQ,PPP1R11,SDHC,KLF4,TXNRD1,FOSB,RBX1,CAPN2,INSR,HTRA1,SIRPA,HSPB1,PEBP1,IGFBP4,SCD,MSR1,BARD1,PDGFC,HNRNPK,IRAK1,HLA-G,EDN1,TIMP1,RHOBTB2,CFH,MCRS1,STAT1,KRT14,NQO1,DVL1,G6PD,SOD1,PDLIM4,NFE2L1,KIFC3,CAPNS1,SLC25A5,RPLP0,ITSN1,HRAS,GLO1,DYNLL1,AHSA1,ABCC1,TXN,ZBTB16,NAPA,SFRP4,CAPN6,STOML2,CKAP2,HMGA1,DPH2,RTN4,SFRP1,CYR61,GSTP1,S100A11,ADAM17,RAB32,KAZN,ASNS,UCHL1,JUN,ACSM5,TOP2A,STIM1,NACC1,FKBP5,ACVR1C,RPS24,WSB1,RPS19,TRIM28,EGR1,APP,PI3,USP22,PRMT5,PEA15,CYCS,NCAM1,PER1,CD4,UNC5B,UBA2,CTBP1,G0S2,ITGAV,KPNA2,SIAH2,RET,PRKRA,MIF,SPP1,GPS2,LMO4,HSPA9,PHB2,RAC1,RASD1,PKN1,MAPT,MAPK10,AKR1B1,VDAC1,LEP,ERN1,PKM,SMPD1,HIF1A,DTYMK,FAS,HMOX1,HINT1,PARK7,THBS1,VCP,TGFB2,KIT,S100A8,NLRC4,PRNP,TAF6,MAPK9,CSF1R,NDUFA13,FAU,ENO1,MAT2A	212	
Dermatological Diseases and Conditions, Inflammatory Disease, Inflammatory Response	dermatitis	Dermatitis	2.36E-11	 	1.189	 	1.928	PER1,SOCS3,PLIN1,TGFBR1,AGER,CD4,FCER1A,NCSTN,STARD7,MKI67,CXCL9,ODC1,POR,LGMN,PIK3CG,IFI30,TUBA1C,MUCL1,NAPA,CBR1,TOP3B,IL2RG,TRIOBP,CFL1,TUBB2A,MAD2L2,TPM3,CPVL,FLOT1,CAPG,BRF2,DSG1,MNT,MYL9,SPINK5,PSMB2,IL1RN,CST6,C3AR1,LCP2,GSTP1,UBE2I,S100A11,APOE,ADAM17,CD2,HLA-A,HLA-DQA1,ADIPOQ,FKBP1A,SMPD1,CD74,IL17RA,FAS,S100A7,JUN,TIMP1,THBS1,FLNA,ANXA1,ANXA5,DUSP10,VCP,HLA-DRA,TOP2A,KIT,S100A8,STIM1,STAT1,KRT10,NLRC4,P4HA2,KRT14,CAPZB,TUBB4B,FCGR2A,IGKC,TUBG1,KRT5,S100A2,ITGB2,ENO1,NR4A2,PSMD2,FCER1G,NR4A1,FKBP4,MS4A2,KRT6A,PSAP,ARHGDIA	91	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of phagocytes	2.38E-11	Increased	3.732	bias	0.594	AGER,PIK3R1,CTSG,HRAS,CXCL9,CXCL10,CTSS,PIK3CG,ABCC1,TXN,AIF1,TMSB10/TMSB4X,TP53,FLOT1,ANXA2,NINJ1,PIP5K1C,MS4A4A,RTN4,IL10RA,CTSB,ALCAM,PLTP,SFRP1,CYR61,C3AR1,APOE,ADAM17,DAPK2,ADIPOQ,PPIA,CD74,S100A7,CES1,GBA,PTPRJ,STIM1,ADORA1,HCAR2,NFE2L2,GJB2,CCR1,RPS19,CD209,FCGR2A,TYROBP,ALOX5AP,ENG,APP,GRN,ITGB2,MT-ND1,GLIS2,TREM2,FCER1G,SOCS3,PLCB2,PFN1,CD4,UNC5B,CD28,RSPO3,NARS,CXCL14,ITGAV,CYBB,STAB1,C1QBP,PTX3,MIF,SPP1,RAC1,CAPG,TPSAB1/TPSB2,PREX1,IL1RN,SH2B3,CD14,SIRPA,CD151,HSPB1,LITAF,LEP,HIF1A,IL17RA,FAS,HMOX1,EDN1,FLNA,THBS1,TIMP1,SAA1,DUSP10,ANXA1,TGFB2,KIT,S100A8,CFH,MAPKAPK2,NLRC4,PRNP,THBS4,VCAM1,NQO1,MAPK9,GIT1,PLXND1,CSF1R,C6,NCKAP1L,P2RX7	111	
Neurological Disease, Psychological Disorders	dementia	Dementia	3.60E-11	 	 	 	 	APOB,AGER,C9orf72,PIK3R1,RAN,NCSTN,MT-CO2,ADGRL1,CXCL10,LGMN,CTSS,ATF4,TXN,UNG,TP53,SNRPA,PLD3,PPTC7,LARP4,HMGA1,CD68,MS4A4A,STIP1,CTSB,GAPDH,PLTP,SQSTM1,ESR2,MT-TL1,APOE,CHCHD10,MS4A6A,DDIT3,UBQLN1,FGF2,SLC1A3,CD74,S100A7,UCHL1,JUN,GBA,MT-CO3,NFE2L2,FCGR3A/FCGR3B,ALDH5A1,FCGR2A,TYROBP,IGKC,MT-ND4,PLA2G2A,APP,GRN,FIS1,MT-ND1,NTRK3,SREBF2,TSPO,PSAP,DCX,ADRA1A,PRKACB,GAB2,TUBB,HSPA5,BIN1,CTSD,PACS2,GM2A,HSPA9,HNRNPAB,SYP,MT-TC,EPRS,PREX1,ADAM12,MAPT,SLC7A2,MAPK10,CD14,INSR,HTRA1,DOK5,SCD,LEP,SMPD1,HIF1A,MT-TN,HMOX1,ALDH2,PARK7,BCYRN1,TIMP1,VCP,SENP3,IGSF8,PRNP,MT-CO1,MT-ND6,SPG21,MT-TQ,NQO1,MAPK9,SOD1,CSF1R,SERPINE2,CXCL16,TMEM2,MT-ND5,APLP2,APOC1,SLC1A2,RTN3	112	
Inflammatory Disease	chronic inflammatory disorder	chronic inflammatory disorder	3.67E-11	 	-0.861	 	-0.496	TMEM266,C9orf72,AGER,CTSG,C1QA,CLSTN2,HLA-DQB1,CXCL9,PANX1,GSS,PTPRC,SKIV2L,CXCL10,POR,DYNLL1,IP6K3,GAA,PIK3CG,ATF4,CHCHD2,TXN,AIF1,HIST1H2AC,TP53,CERS6,RBM38,LCP1,TNFRSF10B,MSMO1,FGFR2,IRF5,ARHGDIB,HSPA8,TMEM127,CD68,PSMB2,CNTNAP4,MS4A7,IL10RA,CTSB,ALDOA,GLUL,C3AR1,FTH1,APOE,FCGRT,ADAM17,GADD45B,DDIT3,MS4A6A,FGF2,HLA-A,HSPB8,HLA-DQA1,ADIPOQ,LGALS9,ST6GALNAC4,FKBP1A,GPC4,SDC3,CD74,UCHL1,LYZ,JUN,TNXB,HLA-DRA,TOP2A,SLC19A1,FKBP5,ALPK2,ADORA1,RPL31,FCGR3A/FCGR3B,MYL12A,RPS24,CCR1,S100A1,FCGR2A,IGKC,TRIM28,DGAT2,PLA2G2A,APP,GRN,FOS,ITGB2,PI3,RPS16,NR4A2,TENM4,NR4A1,MS4A2,TSPO,NR5A2,ADRA1A,SOCS3,SLC7A11,KCND3,ARF1,PRMT3,CD4,TYMP,SDC4,HSPA5,TRIM31,LDHB,NRSN2,CD28,CTSD,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,CYBB,RPL19,STAB1,RFLNB,RPL32,MIF,SPP1,LMO4,RAB10,CAPG,PPP1R11,FOSB,SEL1L,IL1RN,SLC7A2,FMN2,NAGLU,INSR,RPSA,IGFBP4,LEP,PRDX5,PKM,SLC7A1,TPGS2,CD83,IL17RA,RAMP2,FAS,NELFE,HLA-G,HMOX1,SLFN5,EDN1,PPP1R9B,RPL18A,CCSER2,TIMP1,THBS1,ANXA1,SAA1,TGFB2,S100A8,CFH,STAT1,MAPKAPK2,ALPL,PRNP,VCAM1,VSIG4,ATIC,FAU,FGF1,CXCL16,ENO1,APLP2,PSMD2,DYM,SLC1A2,MAP4K4	174	
Nucleic Acid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of nucleoside triphosphate	3.76E-11	Increased	2.536	bias	0.779	SOCS3,ATP5G1,ATP5D,CHCHD10,AGER,PKM,NME2,ATP5L,HIF1A,DTYMK,FAS,NNMT,AK1,G0S2,UQCC2,ENTPD5,VCP,ATP5J2,MT-CO3,LONP1,TP53,ATP5J,MT-ATP6,UCP2,LETM1,USMG5,DCTPP1,SURF1,SOD1,GUK1,CTPS1,APP,HSPA8,MAPT,ALDOA,CYCS,INSR,SLC25A5,VDAC1	39	
Cardiovascular Disease	peripheral arterial disease	intermediate disease stage peripheral arterial disease	4.47E-11	 	 	 	 	APOE,LAPTM5,EEF1B2,CD83,CECR1,THBS1,CTSS,TGFB2,PLEKHO2,IFI30,LOC102724428/SIK1,DAB2,CFH,SLCO2B1,FCGR3A/FCGR3B,GULP1,CCR1,CD53,LCP1,UCP2,SPP1,LAIR1,FCGR2A,CPVL,VSIG4,CAPG,POLR2K,FYB,PLXND1,KLF4,ARHGDIB,NGRN,CTSA,NR4A2,EVI2B,BTG2,CTSB,TPP1,PLTP,MAP4K4,C3AR1,TMEM176B	42	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoplasm	4.77E-11	Increased	4.152	bias	0.265	CRYAB,TGFBR1,AGER,PCLO,PIK3R1,C1QA,CXCL9,PLEKHM2,SLC9A1,CLIP1,AJUBA,GLB1,PLXNB2,KNSTRN,TMSB10/TMSB4X,TP53,LCP1,MTSS1,CARMIL1,MAD2L2,TPM3,FLOT1,FGFR2,LARP4,ARHGDIB,TMEM127,BTG2,GAPDH,ACTG1,RAP2A,APOE,NME1,PEX3,CHCHD10,FGF2,GDF15,ADIPOQ,HEXA,CKAP4,SYNM,SHTN1,SORBS1,PEX10,AMOT,S100A1,WDR36,FCGR2A,GNA12,ENG,CPEB4,GRN,MYO5A,FOS,MYOC,NTRK3,FLNC,PPT1,KRT6A,TPP1,ARHGDIA,SOX9,DCX,PRKACB,NCDN,YWHAH,SEPT9,SESN2,ATP2B1,EML4,MBP,CSNK1A1,FCER1A,NRN1,NNMT,RHOG,HOXA7,CDC42EP1,CNTNAP1,PTPRQ,MAPK8IP2,RIMS4,DMTN,CAPG,UBA6,ARSA,MLST8,TXNRD1,SLC3A2,METRN,ADAM12,NAGLU,CAPN2,INSR,SIRPA,UBE2I,HSPB1,FLRT1,HNRNPK,PHLDB2,HDGF,EDN1,LOC102724428/SIK1,KLHL42,STOX1,LONP1,THBS4,MT-ND6,CAPZB,SLC9A3R1,TUBG1,DVL1,NQO1,HPS1,EMD,SOD1,PDLIM4,GIT1,KIF3B,FGF1,KCTD13,KIFC3,CAPNS1,KIF5B,TTL,TBC1D7,RAB5C,ITSN1,TOR1A,ITGA8,SH3BGRL3,ARPC5,RAN,HRAS,SH3GLB1,KPNA1,MIEN1,CXCL10,DYNLL1,CTSS,ABR,GAA,ABCC1,KIF21A,AFAP1,KIF5C,TESK1,RIMS3,CAPN6,CFL1,STOML2,CKAP2,NINJ1,PIP5K1C,STIP1,RTN4,ALDOA,SFRP1,CYR61,LCP2,BTG3,CDK16,TSGA10,SDC3,ENAH,UCHL1,DCLK2,JUN,SEC61A1,SRGAP1,SNX10,ACAP2,TUB,NPTXR,CALML3,PTPRK,KRT6B,EGR1,APP,FIS1,TENM4,TREM2,ADCY1,FKBP4,P2RY12,GABARAP,RUFY3,MAPRE3,NCAM1,PFN1,ARF1,MAP1B,UNC5B,SDC4,DYNLT1,TUBB,CFL2,COMT,ITGAV,NEO1,C1QBP,RET,RFLNB,PTX3,SPP1,BMP2K,ACP2,PHB2,RAC1,RAB10,SIPA1L1,LMCD1,PREX1,MAPT,MAPK10,RARRES3,PLEK,ARL2,SPIRE1,LEP,RNF165,STMN2,EPB41L3,CD2,PDGFA,NLGN1,ERN1,VAPA,PKM,SMPD1,FAS,TNFRSF12A,PARK7,PPP1R9B,FLNA,THBS1,ANXA1,TGFB2,KIT,ARHGEF2,NSMF,S100A8,MAPKAPK2,ACTN1,PRNP,MAPK9,F13A1,PLXND1,CSF1R,KIF2A,DYM,EPHB3,NCKAP1L,RTN3,P2RX7	254	
Carbohydrate Metabolism	metabolism	metabolism of carbohydrate	5.05E-11	Increased	3.026	bias	0.216	GFPT1,TGFBR1,PLIN1,RPE,PIK3R1,VAC14,HRAS,SH3GLB1,GLO1,CHST2,CXCL10,PTPRC,GNB1,IP6K3,GYS1,CCND3,GLB1,GAA,PIK3CG,ATF4,MGAT1,SERINC2,NR1D1,PIP5K1C,CTSB,GAPDH,ALDOA,SFRP1,EPHX1,APOE,HLA-A,FGF2,DUSP6,HS2ST1,DPM2,ADIPOQ,HEXA,PFKL,SORBS1,ADORA1,PI4KA,ALDH5A1,MBOAT7,FCGR2A,FUCA2,DGAT2,AGPAT1,PLA2G2A,APP,ITGB2,NR4A2,NTRK3,NR4A1,HAGH,ADRA1A,SOCS3,PLCB2,PFKFB1,ARF1,LHCGR,CHST15,CD28,HS6ST1,PGD,CYP3A5,ITGAV,CHST11,PGP,GOT1,MTMR2,GPC1,DPM3,PPP1CA,CBR1,HK1,PFKFB3,FUCA1,MIF,SPP1,XYLT1,GM2A,TALDO1,GNG2,RAC1,RAB10,GPAA1,GYS2,ADCYAP1R1,IL1RN,MPDU1,NAGLU,PLEK,INSR,AKR1B1,ANGPTL8,SCD,PTGFR,LEP,PDGFA,PKM,MAN1B1,HIF1A,FAS,ALDH2,EDN1,ANXA1,TGFB2,KIT,STK40,ADCY2,SLC9A3R1,NPY1R,NQO1,ST3GAL6,G6PD,PYGB,GUK1,SLC5A3,CSF1R,GBE1	120	
Cancer, Organismal Injury and Abnormalities	benign neoplasia	benign neoplasia	5.11E-11	 	-0.116	bias	1.024	CRYAB,KDM6B,RPE,AGER,AHCYL1,PIK3R1,ASS1,MAF,HRAS,COL8A1,MKI67,MT-CO2,NPAS2,ADGRL1,ODC1,POR,ZBTB7B,CCND3,AJUBA,KEAP1,PIK3CG,PLXNB2,UNG,WNT5B,TP53,SLC2A5,CAPN6,DPT,PLD3,BCOR,SLC24A3,PAQR3,TUBB2A,FGFR2,ANXA2,HMGA1,AP2S1,SPON2,ANGPTL1,CCND2,MRPL17,CTSB,ALDOA,ALCAM,ARHGAP35,GLUL,SFRP1,CYR61,ESR2,RORB,GSTP1,FTH1,S100A11,APOE,HIST1H1C,DDIT3,FGF2,PHLDA2,HLA-A,PAM16,CUBN,CTNNA1,ADIPOQ,FKBP1A,COL15A1,COL16A1,FANCE,CADM2,JUN,ANXA5,TOP2A,SLC19A1,DAB2,TPO,NFE2L2,PI4KA,FCGR3A/FCGR3B,RPS19,EGR1,DGAT2,MT-ND4,ENG,TRIB3,STXBP6,PLA2G2A,AIP,APP,FOS,COL5A3,AFF3,NR4A2,SLC48A1,ATP6V1F,NTRK3,NR4A1,PRMT5,PEA15,NR5A2,SOX9,SEMA3C,DCX,ADRA1A,NCAM1,SOCS3,PER1,KCND3,MEGF9,LHCGR,RAB9A,RNASE1,CES2,CEBPG,PLCE1,RHOG,ENTPD5,CXCL14,RPL19,SLC7A5,STAB1,ANXA7,RET,PSMA6,SPP1,SDHC,PIK3R3,C9orf16,KCNG1,ADCYAP1R1,ADAM12,ACKR3,SH2B3,CDH20,INSR,TMEM176B,UBE2I,SCD,IGFBP4,CARS,SDHB,LEP,STMN2,EPB41L3,DNASE1L3,PRDX5,PKM,SLC7A1,MAN1B1,DMD,HIF1A,PDGFC,PLPP1,RAMP2,FAS,TNFRSF12A,HMOX1,ALDH2,HINT1,PARK7,TIMP1,THBS1,ANXA1,VCP,KIT,ARHGEF2,S100A8,CFH,STAT1,ASAP3,PSAT1,VCAM1,COL5A2,DLGAP4,SLC12A2,DVL1,NQO1,VSIG4,MAPK9,S100A2,CSF1R,SLC5A3,SERPINE2,RPS15,PCCA,PAG1,CXXC5,EPHB3,ATP6V1B2	187	
Protein Synthesis	synthesis	synthesis of protein	5.71E-11	 	1.246	 	0.528	GAB2,MT-TT,CD4,PIK3R1,OGFOD1,HSPA5,PTPRC,EIF3B,EIF3D,RPL19,ATF4,GPC1,MYBBP1A,PPP1CA,TP53,EIF2AK1,PRKRA,RHEB,SPP1,NANOS1,KLHL25,MT-TC,MT-TE,MARS,EPRS,MTPN,MRPL17,MAPT,STIP1,BTG2,GAPDH,RPS15A,EIF5A,INSR,PLTP,RPL41,CNBP,HSPB1,MT-TL1,MT-TP,BANK1,LEP,RPS3A,DDIT3,FGF2,ERN1,HSPB8,ADIPOQ,SLC7A1,FKBP1A,MRPL39,H2AFZ,RPS4X,HNRNPK,FAS,MT-TN,FARSB,JUN,PARK7,EDN1,THBS1,ANXA1,PPP1R2,MT-TS1,ARHGEF2,RPS5,SARS,MT-TD,PRNP,RPS24,NACA,MT-TY,MT-TQ,RPL17,RPL30,DNAJC1,SOD1,MKNK2,RPS29,CPEB4,APP,EIF3G,FOS,WARS,MRPL51,FAM129A,RPS27L,EIF3I,RPL37,CPEB1,RPL38	91	
Neurological Disease	leukoencephalopathy	leukoencephalopathy	6.83E-11	 	-1.067	 	-0.796	APOE,NDUFA9,RRM2B,TYMP,NDUFA2,CERS2,SCO2,KIT,MT-CO3,RET,MT-ND2,NDUFS4,MT-ATP6,MT-ND6,MT-TY,MT-TQ,SURF1,MT-ND4,MT-TC,ARSA,CSF1R,MT-ND1,MT-ND5,NDUFS8,MAPT,NDUFA12,PSAP,MT-ND3,NDUFS3,HTRA1,MT-TL1	31	
Protein Synthesis	expression	expression of protein	7.60E-11	 	-0.546	 	-0.357	GAB2,MT-TT,OGFOD1,HSPA5,PTPRC,EIF3B,EIF3D,RPL19,MYBBP1A,GPC1,PPP1CA,TP53,EIF2AK1,PRKRA,RHEB,SPP1,NANOS1,KLHL25,MT-TC,MT-TE,MARS,EPRS,MRPL17,MAPT,BTG2,GAPDH,EIF5A,RPL41,CNBP,HSPB1,MT-TL1,MT-TP,BANK1,LEP,RPS3A,ERN1,FGF2,SLC7A1,MRPL39,RPS4X,HNRNPK,MT-TN,FAS,FARSB,JUN,THBS1,ANXA1,MT-TS1,ARHGEF2,SARS,RPS5,MT-TD,PRNP,NACA,RPS24,MT-TY,MT-TQ,RPL17,RPL30,DNAJC1,SOD1,RPS29,CPEB4,APP,EIF3G,FOS,WARS,MRPL51,RPS27L,EIF3I,RPL37,CPEB1,RPL38	73	
Nucleic Acid Metabolism, Small Molecule Biochemistry	biosynthesis	biosynthesis of nucleoside triphosphate	8.74E-11	Increased	2.536	bias	0.744	SOCS3,ATP5G1,AGER,CHCHD10,ATP5D,PKM,NME2,HIF1A,DTYMK,FAS,NNMT,AK1,G0S2,UQCC2,VCP,MT-CO3,LONP1,TP53,MT-ATP6,UCP2,LETM1,USMG5,SURF1,SOD1,CTPS1,APP,MAPT,ALDOA,CYCS,INSR,SLC25A5,VDAC1	32	
Cardiovascular Disease	peripheral vascular disease	peripheral vascular disease	1.02E-10	 	-0.181	 	0.291	APOB,AGER,SNTA1,SLC9A1,NPL,CECR1,NNMT,HSPA4,CTSS,PLEKHO2,IFI30,CYBB,ITGAV,TUBA1C,SLCO2B1,UNG,GULP1,TP53,LCP1,SPP1,LAIR1,TUBB2A,CPVL,CAPG,POLR2K,FYB,KLF4,ARHGDIB,NGRN,LMCD1,CTSA,NPR3,EVI2B,MAPT,BTG2,CTSB,INSR,PLTP,C3AR1,TMEM176B,FTH1,HSPB1,APOE,LAPTM5,MSR1,HYOU1,EEF1B2,ADIPOQ,ADAP2,CD83,CKAP4,HIF1A,FAS,TNFRSF12A,EDN1,THBS1,TGFB2,SNX10,LOC102724428/SIK1,DAB2,CFH,HCAR2,FCGR3A/FCGR3B,PRNP,CCR1,CD53,VCAM1,UCP2,FCGR2A,TUBB4B,HSPH1,TUBG1,ALOX5AP,F13A1,VSIG4,ENG,PLXND1,APP,NR4A2,TPP1,P2RY12,SLC1A2,MAP4K4,ADRA1A	84	
Immunological Disease	allergy	allergy	1.06E-10	 	1.559	 	0.920	GAB2,PER1,PLIN1,TGFBR1,AGER,FCER1A,HLA-DQB1,MKI67,STARD7,CXCL9,HSPA5,TUBB,CD63,PTPRC,CD28,LGMN,CTSS,PIK3CG,IFI30,MUCL1,NAPA,CBR1,PFKFB3,TRIOBP,CFL1,MAD2L2,HNRNPAB,CPVL,TPM3,FLOT1,CAPG,BRF2,MNT,MYL9,PREX1,SPINK5,IL1RN,GAPDH,ALDOA,CST6,C3AR1,LCP2,UBE2I,S100A11,ADAM17,LEP,CD2,HLA-DQA1,ADIPOQ,PPIA,FKBP1A,SMPD1,CD74,S100A7,ALDH2,JUN,TIMP1,FLNA,ANXA1,DUSP10,ANXA5,VCP,HLA-DRA,KIT,S100A8,STIM1,ALPK2,STAT1,ADORA1,KRT10,P4HA2,CAPZB,FCGR2A,ALOX5AP,KRT5,S100A2,ENO1,NR4A2,FCER1G,FKBP4,MS4A2,KRT6A,PSAP,PDE8B,ADRA1A	85	
Gene Expression, Protein Synthesis	translation	translation of RNA	1.31E-10	 	-1.706	bias	 	BANK1,MT-TT,RPS3A,OGFOD1,MRPL39,RPS4X,MT-TN,FARSB,EIF3B,EIF3D,MT-TS1,RPL19,PPP1CA,RPS5,SARS,MT-TD,RPS24,NACA,EIF2AK1,NANOS1,MT-TY,KLHL25,MT-TQ,RPL17,RPL30,MT-TC,DNAJC1,MT-TE,RPS29,EPRS,APP,EIF3G,WARS,MRPL51,MRPL17,RPS27L,BTG2,EIF3I,GAPDH,RPL37,CPEB1,RPL41,RPL38,MT-TP,MT-TL1,HSPB1	46	
Cardiovascular Disease	peripheral arterial disease	peripheral arterial disease	1.36E-10	 	 	 	 	CECR1,HSPA4,CTSS,PLEKHO2,IFI30,SLCO2B1,GULP1,LCP1,SPP1,LAIR1,CPVL,POLR2K,CAPG,FYB,KLF4,ARHGDIB,NGRN,LMCD1,CTSA,NPR3,EVI2B,BTG2,CTSB,PLTP,TMEM176B,C3AR1,FTH1,APOE,LAPTM5,MSR1,EEF1B2,ADAP2,CD83,THBS1,SNX10,TGFB2,LOC102724428/SIK1,DAB2,CFH,FCGR3A/FCGR3B,CD53,CCR1,UCP2,FCGR2A,HSPH1,VSIG4,PLXND1,NR4A2,P2RY12,TPP1,MAP4K4	51	
Cancer, Organismal Injury and Abnormalities	cancer	cancer	1.37E-10	 	-0.308	 	-0.249	TGFBR1,PCLO,ASS1,C1QTNF5,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,ANXA2,LARP4,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,UTP18,BANK1,PIM3,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,SCNN1B,ALPK2,AMOT,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,ST20,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,HS6ST1,LHFPL2,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,MT-ND2,NSMAF,GUF1,PIK3R3,SPINK5,RBX1,CCDC43,NAGLU,TMX2,INSR,KCTD19,NDUFS3,CBX3,POLD2,FAM134A,ETV5,SCD,SUMO3,FOXRED2,CARS,FLRT1,FAT3,NHP2,RPL7A,C20orf24,HDGF,IGSF8,ISCU,CFH,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,RNF26,SNTB1,TCEA3,PYGB,SOD1,SAA2,DHX8,SNX27,RPS29,VAT1,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,C15orf59,RPLP0,TUBA1B,GFPT1,SNTA1,ITGA8,HLA-DQB1,GLO1,MIEN1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,NAPA,POLR2I,SFT2D2,UBXN6,COMMD9,KAZALD1,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SCRN1,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,ASTE1,COASY,SDC3,ATP6AP1,H2AFZ,RNF185,MAFG,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,ACVR1C,RPL31,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,CD209,NAP1L4,RRP1B,ANKRD9,SYNGR2,EGR1,TRIM28,COPS3,STS,PSMD8,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,NIPSNAP3A,AOX1,NCAM1,PNO1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,NMNAT2,CHST11,PGP,GOT1,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,LAGE3,ANKMY2,FAM45A,RPL12,ATP10A,TARS,SLC39A3,GALNT13,ATP6V1A,TPSAB1/TPSB2,PREX1,TMEM189,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,NELFE,MPEG1,FAM171A2,CLCN4,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,RPS21,KIFAP3,THRSP,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,RRM2B,CA5B,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,SLCO2B1,MRPL24,DPT,PLD3,LHPP,ICT1,MTSS1,KLHL25,PAQR3,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,ZNF69,CD52,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,GJB6,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,ATRAID,SDHAF1,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,DCUN1D5,BZW2,TRAF3,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,RNASE1,TYMP,IMP4,CES2,SLC35F6,BIN1,CEBPG,NNMT,CD28,TMEM132C,SAE1,CYP3A5,RPS13,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,MUCL1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,SDHC,UBA6,ARSA,MT-ND4L,GYS2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,ME1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,ATP6V1E1,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,SPCS1,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,ADGRL1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ARRDC4,CSRP2,STOML2,TSPAN33,PDE1C,SERINC2,PSMB2,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,MT-ND3,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,PSMB10,BCO2,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,TAX1BP3,CA3,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,LAMP1,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,ADCK2,PEA15,PRMT5,P2RY12,CYCS,DNPH1,SCAMP3,RUFY3,MAPRE3,GPR137,HOXB5,MVD,GAB2,RPS23,CLTB,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,LMO4,GPS2,ANLN,GLYAT,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,PRDX5,PDGFA,SLC30A2,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,FAU,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,TMEM184B,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,EIF3B,ATG9A,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,LAIR1,SURF1,MSMO1,IRF5,CTSB,C15orf39,NHLH1,PLTP,FTH1,EPHX1,CD163L1,EVA1B,GADD45B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,IGKC,SLC25A1,ENG,MAGEC3,CSTB,MYO5A,RPS16,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,RPL37A,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,UBE2I,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,FARS2,KLHL42,STAT1,MT-CO1,THBS4,PREB,TRIM55,IPO4,G6PD,CSRNP1,TSN,KIF3B,APOLD1,APLP2,CPAMD8,THEMIS2,ARPC5,RAN,SRP19,GHITM,DDX20,MKI67,GSS,EEF1D,HPCAL1,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,SSBP1,C19orf53,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,DHRSX,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ASNS,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,MYL12A,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,SLIRP,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,PSME1,HIST1H1E,SLC48A1,CCDC85B,GLIS2,RNF144A,BRINP2,RHBDD2,TREM2,USP22,APOL4,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,UBE2A,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,C1QBP,RILP,HIST1H4H,RET,MDH2,BCKDK,LANCL1,C7orf50,MRPS15,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PSMA6,PACSIN3,TRIOBP,GSDMB,XYLT1,GNG2,HSPA9,TALDO1,RAC1,CPVL,HIST1H2BK,GPAA1,RASD1,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,PLEK,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,SH3RF3,CNRIP1,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,TBCB,RRAGD,OAZ1,FMO1,WSB2,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,IL20RB,KIAA1683,ACSM2B,PLBD2,TMEM2,APOC1,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,RPL38,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,KEAP1,MCOLN3,FRAS1,ST6GALNAC2,ATF4,SCPEP1,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TSPYL5,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,TPM3,BRF2,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,PRELP,GAPDH,UCK1,MARCH4,TULP3,LYPLA1,TMEM33,RPL41,STEAP3,PPDPF,RAP2A,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,CD74,ZNF827,SLC35B2,GLIPR1,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,LURAP1L,TTC23,FAM96B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,WDR36,TMC2,SRA1,ALOX5AP,TRIB3,HSPA2,SPTLC3,GRN,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,SEMA3C,TSC22D2,TTYH3,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,HSPA4,KRTAP4-6,RHOG,ZNRF3,EIF3D,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,C17orf53,CHMP1A,CBR1,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,MT-TE,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,CDH20,SLC25A39,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,CD151,RPSA,DOK5,ATP6V0C,UBXN1,SYCE1,SF3B5,MSR1,DMD,IL17RA,PDGFC,NDUFA2,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,CXCL16,CISD1,SHB,CIDEA,KIFC3,LGALS2,KIF5B,TTL,EIF3I,C1orf226,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,PLIN1,APOB,ITSN1,AHCYL1,C9orf72,TOR1A,TXNL4A,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,NANOS1,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,PTPA,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,MS4A6A,TCEA1,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,S100A7,PIP,FANCE,UCHL1,RPL35,SEC61A1,ACSM5,GBA,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,CALML3,SLC7A6,ADGRB2,NDUFS4,MBOAT7,ADRM1,LETM1,TYROBP,TBC1D9,MT-ND4,KRT5,APP,AREL1,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,FCER1G,MS4A2,NR5A2,DVL3,CBX4,GABARAP,ACTR1A,EFR3A,MT-TT,SLC7A11,ATP5D,XPO5,RAB9A,UTP4,MMRN1,TAF10,SDC4,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,NARS,PGD,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,PKM,CUTA,VAPA,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,ERV3-1,TNFRSF12A,SEPHS2,HMOX1,RNF167,PCK2,KCNMA1,NDUFC2,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,CTDNEP1,STK40,HMGCS1,ACTN1,PRNP,NDUFAF3,NACA,COX17,TAF6,CD160,VANGL1,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1416	
Protein Synthesis	translation	translation	1.49E-10	 	-0.256	 	0.117	MT-TT,OGFOD1,HSPA5,EIF3B,EIF3D,RPL19,PPP1CA,TP53,EIF2AK1,PRKRA,RHEB,NANOS1,KLHL25,MT-TC,MT-TE,MARS,EPRS,MRPL17,MAPT,BTG2,GAPDH,RPS15A,EIF5A,CNBP,RPL41,HSPB1,MT-TL1,MT-TP,BANK1,RPS3A,ERN1,SLC7A1,MRPL39,RPS4X,MT-TN,HNRNPK,FARSB,MT-TS1,SARS,RPS5,MT-TD,NACA,RPS24,PRNP,MT-TY,MT-TQ,RPL17,RPL30,DNAJC1,RPS29,CPEB4,APP,EIF3G,MRPL51,WARS,RPS27L,EIF3I,RPL37,CPEB1,RPL38	60	
Protein Synthesis	translation	translation of protein	1.91E-10	 	-0.487	 	-0.063	MT-TT,OGFOD1,HSPA5,EIF3B,EIF3D,RPL19,PPP1CA,TP53,EIF2AK1,PRKRA,RHEB,NANOS1,KLHL25,MT-TC,MT-TE,MARS,EPRS,MRPL17,MAPT,BTG2,GAPDH,EIF5A,CNBP,RPL41,HSPB1,MT-TL1,MT-TP,BANK1,RPS3A,ERN1,SLC7A1,MRPL39,RPS4X,MT-TN,HNRNPK,FARSB,MT-TS1,SARS,RPS5,MT-TD,NACA,RPS24,PRNP,MT-TY,MT-TQ,RPL17,RPL30,DNAJC1,RPS29,CPEB4,APP,EIF3G,MRPL51,WARS,RPS27L,EIF3I,RPL37,CPEB1,RPL38	59	
Immunological Disease	immediate hypersensitivity	immediate hypersensitivity	1.94E-10	 	1.330	 	0.930	GAB2,PER1,PLIN1,FCER1A,STARD7,MKI67,CXCL9,CD63,PTPRC,CD28,LGMN,PIK3CG,IFI30,MUCL1,NAPA,CBR1,TRIOBP,CFL1,MAD2L2,TPM3,CPVL,FLOT1,CAPG,BRF2,MNT,MYL9,SPINK5,IL1RN,CST6,C3AR1,LCP2,UBE2I,S100A11,ADAM17,CD2,HLA-DQA1,ADIPOQ,PPIA,FKBP1A,SMPD1,CD74,S100A7,JUN,TIMP1,FLNA,ANXA1,ANXA5,DUSP10,VCP,HLA-DRA,KIT,S100A8,STIM1,STAT1,KRT10,P4HA2,CAPZB,FCGR2A,ALOX5AP,KRT5,S100A2,ENO1,NR4A2,FCER1G,FKBP4,MS4A2,KRT6A,PSAP,ADRA1A	69	
Gene Expression, Protein Synthesis	translation	translation of mRNA	2.28E-10	 	-1.706	bias	 	BANK1,MT-TT,RPS3A,MRPL39,RPS4X,MT-TN,FARSB,EIF3B,EIF3D,MT-TS1,RPL19,PPP1CA,RPS5,SARS,MT-TD,RPS24,NACA,EIF2AK1,NANOS1,MT-TY,KLHL25,MT-TQ,RPL17,RPL30,MT-TC,DNAJC1,MT-TE,RPS29,EPRS,APP,EIF3G,WARS,MRPL51,MRPL17,RPS27L,BTG2,EIF3I,GAPDH,RPL37,CPEB1,RPL41,RPL38,MT-TP,MT-TL1,HSPB1	45	
Gene Expression	expression	expression of mRNA	3.10E-10	 	-0.867	 	-0.267	MT-TT,PFN1,EEF1D,CD28,EIF3B,EIF3D,RPL19,PPP1CA,TP53,EIF2AK1,NANOS1,KLHL25,MT-TC,MT-TE,PKN1,EPRS,MRPL17,BTG2,GAPDH,RPL41,HSPB1,MT-TL1,MT-TP,BANK1,RPS3A,DDIT3,MRPL39,RPS4X,MT-TN,FARSB,JUN,MT-TS1,TUB,STAT1,SARS,RPS5,MT-TD,NACA,RPS24,MT-TY,MT-TQ,EGR1,RPL17,RPL30,DNAJC1,RPS29,APP,EIF3G,FOS,MRPL51,WARS,RPS27L,EIF3I,RPL37,CPEB1,RPL38	56	
Immunological Disease	systemic autoimmune syndrome	systemic autoimmune syndrome	3.55E-10	 	1.251	 	1.020	TMEM266,C9orf72,AGER,CTSG,C1QA,CLSTN2,HLA-DQB1,CXCL9,PTPRC,SKIV2L,CECR1,CXCL10,DYNLL1,IP6K3,CCND3,CTSS,GAA,PXK,PIK3CG,POU6F2,CHCHD2,TXN,AIF1,HIST1H2AC,EYA2,TP53,CERS6,RBM38,LCP1,TNFRSF10B,FLOT1,IRF5,CD52,ARHGDIB,HSPA8,TMEM127,CTSA,SCUBE1,CD68,CNTNAP4,MS4A7,IL10RA,CTSB,ALDOA,GLUL,RAMP3,TCF7,C3AR1,FTH1,BANK1,APOE,FCGRT,GADD45B,MS4A6A,FGF2,HLA-A,HSPB8,HLA-DQA1,ADIPOQ,ST6GALNAC4,FKBP1A,GPC4,SDC3,CD74,ENAH,LYZ,TNXB,HLA-DRA,SLC19A1,FKBP5,ALPK2,RPL31,FCGR3A/FCGR3B,MYL12A,RPS24,CCR1,UCP2,TYROBP,FCGR2A,IGKC,TRIM28,ALOX5AP,AGPAT1,PLA2G2A,ISG15,GRN,FOS,ITGB2,RPS16,NR4A2,FCER1G,NR4A1,C6orf48,TSPO,SOCS3,SLC7A11,RNASE6,ARF1,PRMT3,CD4,TLR8,SDC4,TUBB,TRIM31,LDHB,NRSN2,CD28,CAMK2D,G0S2,UQCC2,RPS13,CXCL14,CYBB,RPL19,NMNAT2,RET,PPP1CA,RFLNB,TBC1D10C,RPL32,MIF,SPP1,LMO4,RAB10,CAPG,PPP1R11,SLC3A2,FOSB,SEL1L,IL1RN,SH2B3,SLC7A2,FMN2,NAGLU,PLEK,INSR,RPSA,CD151,PTGFR,SCD,IGFBP4,SPRED1,LEP,PRDX5,DNASE1L3,SLC7A1,TPGS2,CD83,IL17RA,GANAB,RAMP2,FAS,NELFE,MPEG1,HLA-G,ALDH2,HMOX1,SLFN5,RPL18A,CCSER2,TIMP1,THBS1,ANXA1,SAA1,TGFB2,S100A8,CFH,STAT1,ALPL,PRNP,VCAM1,HPS1,VSIG4,ATIC,FAU,CXCL16,ENO1,APLP2,SGF29,DYM,SLC1A2,MAP4K4,P2RX7	183	
Cellular Movement	cellular infiltration	cellular infiltration of cells	3.95E-10	 	0.980	 	0.186	SOCS3,PLCB2,CRYAB,TGFBR1,AGER,CMA1,PIK3R1,UNC5B,CTSG,HRAS,CXCL9,CXCL10,CD28,RSPO3,PIK3CG,CYBB,ZBTB16,TP53,PTX3,MIF,SPP1,NINJ1,EFS,PREX1,IL1RN,CTSB,CD14,SFRP1,PLTP,CYR61,AKR1B1,C3AR1,ESR2,LCP2,HSPB1,APOE,ADAM17,LEP,MSR1,CD2,FGF2,PDGFA,HLA-A,HYOU1,ADIPOQ,PPIA,DMD,HIF1A,IL17RA,FAS,HMOX1,CES1,GBA,EDN1,TIMP1,THBS1,ANXA1,DUSP10,SAA1,S100A8,STIM1,CFH,STAT1,MAPKAPK2,NFE2L2,KRT10,GJB2,CCR1,VCAM1,UCP2,NQO1,TRPA1,ALOX5AP,ENG,CSF1R,APP,CXCL16,ITGB2,GLIS2,FCER1G,NR4A1,C6,P2RX7	83	
Hereditary Disorder, Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Leigh syndrome	Leigh syndrome	3.97E-10	 	 	 	 	MT-ATP6,MT-ND6,NDUFA9,SURF1,MT-ND4,NDUFA2,MT-ND1,MT-ND5,NDUFS8,NDUFA12,MT-CO3,MT-ND3,NDUFS3,MT-ND2,NDUFS4,MT-TL1	16	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	mammary tumor	mammary tumor	3.99E-10	 	0.919	 	0.369	CRYAB,TGFBR1,WHSC1,AGER,C1QTNF5,PIK3R1,KCMF1,COL8A1,CXCL9,CLIP1,ODC1,POR,IP6K3,CCND3,ARID3B,EIF3B,AJUBA,KEAP1,FRAS1,ATF4,MYBBP1A,MRPL24,TP53,SRPRA,PROSC,PPP1R1B,KCTD16,TNFRSF10B,FGFR2,BRF2,ARHGDIB,HAX1,NRBP1,CTSA,SCUBE1,BTG2,DUSP4,NHLH1,LYPLA1,ESR2,STEAP3,FTH1,EPHX1,BANK1,APOE,NME1,GADD45B,FGF2,HSPB8,ADIPOQ,ATRAID,COL16A1,SHTN1,RABL6,PTPRJ,TNXB,PLIN2,ATP5J2,DAB2,FAM96B,ADORA1,HCAR2,NFE2L2,RPL4,TUBB4B,GNA12,SLC39A6,ENG,C1orf122,FOS,MT-ND1,AFF3,NR4A2,NTRK3,MAZ,NR4A1,KRT6A,ARHGDIA,SOX9,HAGH,YWHAH,AKR1C3,SEPT9,NME2,FCER1A,TYMP,HSPA5,BIN1,CTSD,KRTAP4-6,CYP3A5,CXCL14,TUBA1C,CDC42EP1,MUCL1,ADAMTS5,PFKFB3,IL2RG,PCSK6,MT-TE,FYB,KLF4,FOSB,PIK3R3,ADAM12,CCDC43,RBX1,UHRF1BP1L,INSR,KCTD19,CST6,MEGF8,CBX3,TFPT,HSPB1,CD151,MSR1,PLGRKT,MECR,BARD1,DMD,COL6A6,HLA-G,ALDH2,EDN1,TIMP1,LOC102724428/SIK1,RHOBTB2,IGSF8,CFH,STAT1,MCRS1,LONP1,MT-CO1,KRT14,AKR1C1/AKR1C2,SLC9A3R1,NPY1R,TUBG1,NQO1,HPS1,SOD1,PDLIM4,S100A2,CISD2,NFE2L1,FGF1,CISD1,CLGN,LGALS2,CXXC5,SLC25A5,TUBA1B,THEMIS2,CPAMD8,APOB,ITSN1,SRP19,HRAS,MKI67,GLO1,MIEN1,CECR1,CXCL10,BCAT1,FAM91A1,MPV17L2,ABR,ABCC1,PIK3CG,WNT5B,TUBB2A,FARSA,DPH2,CCND2,CD68,C19orf53,MS4A4A,STIP1,RTN4,ALDOA,ARHGAP35,GLUL,KRTAP4-4,SFRP1,AIDA,TCF7,CYR61,MYEOV,GSTP1,HIST1H1C,ADAM17,HLA-A,UBQLN1,CDK16,XPOT,FKBP1A,PFKL,H2AFZ,TAX1BP3,ENAH,S100A7,PIP,FANCE,UCHL1,RPL35,CES1,JUN,GBA,MT-CYB,TOP2A,TRIM16,TUB,TPO,FKBP5,GJB2,LIMCH1,PLOD3,RPS24,RPS19,NAP1L4,LETM1,ADRM1,KRT6B,TBC1D9,EGR1,SLIRP,MT-ND4,KRT5,ATXN2L,COPS3,PLA2G2A,EIF3G,FIS1,CALM1 (includes others),COL5A3,SUPV3L1,SREBF2,CYCS,DVL3,CBX4,MAPRE3,GAB2,MT-TT,PFN1,CD4,LHCGR,UTP4,TUBB,UBA2,MTCH2,GSPT1,CNDP2,SLC25A6,DPP3,COMT,ITGAV,RPL19,KPNA2,SIAH2,C1QBP,RET,EIF2AK1,MIF,SPP1,GSDMB,LAGE3,PSMC4,MARS,PKN1,FMN2,MAPK10,AKR1B1,LEP,ATF5,PRDX5,PDGFA,PCDH19,PKM,SLC7A1,HIF1A,RPS4X,FAS,NELFE,HMOX1,THBS1,FLNA,NDUFC2,ANXA1,VCP,TGFB2,KIT,ARHGEF2,CCDC73,SLC40A1,S100A8,MAPKAPK2,ALPL,HMGCS1,NDUFAF3,NACA,PSMB4,SCN2A,ADCY2,TAF6,TPST2,QSOX1,MAPK9,GUK1,CSF1R,THRSP,ENO1,MT-ND5,CLDN1,UBA1,C6,PPP2R1B,SHMT2	318	
Cellular Development, Cellular Growth and Proliferation	cell proliferation	cell proliferation of breast cancer cell lines	4.73E-10	Increased	3.772	 	1.598	PFN1,SEPT9,ARF1,HRAS,NCSTN,HSPA5,BIN1,SLC9A1,ODC1,CXCL10,CD28,CTSD,CYP3A5,KPNA2,TXN,GPC1,C1QBP,TP53,SPP1,GPS2,PPP1R1B,RAC1,FGFR2,FLOT1,ANXA2,CITED1,HMGA1,KLF4,PIK3R3,SEL1L,CCND2,ADAM12,ACKR3,PIP5K1C,RBX1,BTG2,RARRES3,INSR,CYR61,CST6,ESR2,UBE2I,UBE2J2,CD151,COPS4,NME1,ADAM17,NACC2,LEP,FGF2,OSGIN1,GDF15,PKM,HSPB8,EEF1B2,ADIPOQ,HIF1A,H2AFZ,HNRNPK,RAP1GDS1,ENAH,S100A7,RABL6,JUN,PCK2,SLC19A1,RHOBTB2,DAB2,AMOT,NDUFAF3,S100A1,TAF6,IGKC,TRIM28,NQO1,MAPK9,SOD1,SNCG,COPS3,CISD2,DEGS1,FGF1,RBCK1,GRN,FOS,CISD1,WBP2,UBA1	88	
Energy Production, Nucleic Acid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of ATP	5.90E-10	Increased	2.536	bias	0.760	SOCS3,ATP5G1,AGER,CHCHD10,ATP5D,PKM,HIF1A,FAS,NNMT,G0S2,UQCC2,VCP,MT-CO3,LONP1,TP53,MT-ATP6,UCP2,LETM1,USMG5,SURF1,SOD1,APP,MAPT,ALDOA,CYCS,INSR,SLC25A5,VDAC1	28	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	Mitochondrial complex I deficiency	Mitochondrial complex I deficiency	7.14E-10	 	 	 	 	MT-ND6,NDUFA9,MT-ND4,NDUFA1,NDUFA2,MT-TN,MT-ND1,MT-ND5,NDUFS8,NDUFA11,NDUFA12,MT-ND3,NDUFS3,MT-ND2,NDUFS4,NDUFAF3	16	
Cellular Function and Maintenance	homeostasis	cellular homeostasis	7.38E-10	Increased	4.507	bias	1.397	CRYAB,TGFBR1,AGER,PIK3R1,CTSG,PANX1,SLC9A1,PTPRC,GNB1,ATG9A,MCOLN3,ATF4,STAM,LMX1A,TP53,RHEB,PPP1R1B,TNFRSF10B,ANXA2,IRF5,CD52,HSPA8,CTSA,ATOX1,DUSP4,SQSTM1,ESR2,APOE,SLC4A2,GADD45B,DDIT3,DAPK2,FGF2,HLA-DQA1,ADIPOQ,HSPB8,LGALS9,PPIA,CD74,PTPRJ,SORBS1,BCAP31,SCNN1B,AMOT,NFE2L2,FCGR3A/FCGR3B,TMEM123,CCR1,SIGMAR1,UCP2,FCGR2A,IGKC,GNA12,SLC39A6,TRIB3,ENG,POLDIP2,FOS,NR4A2,NR4A1,ABCC3,SIM1,ADRA1A,ICMT,SOCS3,TRAF3,SEPT9,SESN2,MBP,FCER1A,NME2,RNASE1,HSPA5,CD28,CTSD,HSPA4,AK1,STC2,NUPR1,HOXA7,PPP1CA,IL2RG,STK39,MAPK8IP2,RIMS4,ARSA,KLF4,SLC3A2,SPINK5,COMMD1,INSR,HSPB1,CD151,IGFBP4,SCD,MSR1,BARD1,DMD,IL17RA,HLA-G,EDN1,SAA1,STOX1,STAT1,LONP1,ATP13A2,SLC9A3R1,NPY1R,SLC12A2,NQO1,TRPA1,SOD1,CISD2,NRBF2,GIT1,FGF1,CISD1,CIDEA,GIPR,APLP2,CAPNS1,LGALS2,SLC14A1,KIF5B,PSMD2,FECH,TBC1D7,THEMIS2,PLIN1,ITSN1,C9orf72,SNTA1,MAF,HRAS,SH3GLB1,NCSTN,HLA-DQB1,EEF1D,CXCL10,ZBTB7B,GAA,ABCC1,PIK3CG,KIF5C,ZBTB16,EYA2,SFRP4,RIMS3,SLC24A3,STOML2,HMGA1,MNT,NR1D1,PRELID1,RTN4,IL10RA,ALDOA,ARHGAP35,SFRP1,TCF7,CYR61,C3AR1,LCP2,ADAM17,SLC24A2,HLA-A,BCO2,FKBP1A,MAFG,JUN,GBA,CCL28,LAMP1,STIM1,NACC1,NDUFAB1,AMFR,LETM1,TYROBP,TBC1D9,EGR1,APP,ITGB2,FIS1,FTL,COL5A3,LAMP2,FCER1G,CYCS,PLCB2,SLC31A1,ARF1,CD4,CAMK2D,SLC25A6,PLCE1,CFL2,ITGAV,CYBB,NEO1,ANXA7,CLCN3,TBC1D10C,EIF2AK1,MIF,SPP1,ACP2,PHB2,RAC1,SLC39A3,PKN1,OSTM1,PREX1,IL1RN,MAPT,EIF5A,LFNG,VDAC1,AKR1B1,CYP4A11,PAFAH1B2,FPR3,SDHB,LEP,CD2,ERN1,PKM,SMPD1,CD83,HIF1A,FAS,HMOX1,PARK7,KCNMA1,ANXA1,VCP,KIT,SLC40A1,S100A8,NR2F6,NLRC4,PRNP,DAP,CD160,AP3D1,RAB7A,MAPK9,QSOX1,CLDN1,PAG1,GBE1,NCKAP1L,P2RX7,ATP6V1B2,CARM1	255	
Cell Death and Survival	cell viability	cell viability	7.65E-10	Increased	5.533	bias	0.040	WHSC1,TGFBR1,AGER,ASS1,PIK3R1,RRM2B,CXCL9,SLC9A1,POR,PTPRC,IP6K3,MCOLN3,KEAP1,STAM,UNG,TP53,RHEB,PPP1R1B,TNFRSF10B,MAD2L2,FGFR2,BTG2,CTSB,PSMA4,SQSTM1,ESR2,FTH1,APOE,NME1,GADD45B,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,PPIA,CD74,SYNM,C1QTNF9,OGT,DAB2,BCAP31,ALPK2,ADORA1,NFE2L2,FCGR3A/FCGR3B,CCR1,SIGMAR1,ENG,POLDIP2,FOS,NR4A2,NTRK3,NR4A1,PSAP,SOX9,ABCC3,ABCB6,PRKACB,SOCS3,TRAF3,DCUN1D5,SEPT9,MBP,FCER1A,CSNK1A1,NRN1,TYMP,HSPA5,CD28,PACS2,NUPR1,PPP1CA,CBR1,IL2RG,PCSK6,PFDN5,AURKAIP1,PPP1R11,KLF4,CAPN2,INSR,RPSA,HSPB1,UBE2I,SCD,CARS,MSR1,DNASE1L3,BARD1,HDGF,IRAK1,HLA-G,CIAPIN1,EDN1,TIMP1,STAT1,ATP13A2,VCAM1,USMG5,NPY1R,SOD1,FGF1,KIFC3,APOB,NCSTN,HRAS,CXCL10,SGPL1,PIK3CG,ABCC1,TXN,HMGA1,MNT,ANGPTL1,DPH2,MBD4,SFRP1,TCF7,CYR61,GSTP1,ADAM17,UBQLN1,DUSP6,SLC1A3,HYOU1,KAZN,ASNS,UCHL1,LYZ,JUN,ANXA5,SLC19A1,NACC1,FKBP5,PTPRK,TBC1D9,TYROBP,TRIM28,EGR1,APP,ITGB2,SREBF2,SBF1,FCER1G,NCAM1,GAB2,SLC31A1,CCNI,CD4,UNC5B,ZNF91,CTBP1,PLCE1,CAMK2D,DPP3,ITGAV,CYBB,POMP,GPC1,BCKDK,RET,PSMA6,MIF,SPP1,ANLN,PHB2,RAC1,PSMC4,SEL1L,OSTM1,IL1RN,ACKR3,MAPT,MAPK10,RARRES3,VDAC1,LEP,PDGFA,ERN1,ATF5,PKM,SLC7A1,SMPD1,HIF1A,PLPP1,FAS,CLCN4,HMOX1,HINT1,PARK7,FLNA,THBS1,DUSP10,VCP,TGFB2,KIT,PSMA3,SLC40A1,SELENOH,S100A8,MAPKAPK2,PRNP,PSMB4,MAPK9,CSF1R,THRSP,NDUFA13,ENO1,SLC1A2,EPHB3,PPP2R1B,P2RX7,SHMT2,RPL38	215	
Cell Death and Survival	survival	cell survival	7.87E-10	Increased	5.914	bias	0.385	WHSC1,TGFBR1,AGER,ASS1,PIK3R1,RRM2B,CXCL9,SLC9A1,ODC1,POR,PTPRC,IP6K3,MCOLN3,KEAP1,ATF4,STAM,UNG,TP53,RHEB,PPP1R1B,TNFRSF10B,MAD2L2,FGFR2,BTG2,CTSB,PSMA4,ALCAM,SQSTM1,ESR2,FTH1,APOE,NME1,GADD45B,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,PPIA,CD74,SYNM,C1QTNF9,OGT,DAB2,BCAP31,ALPK2,ADORA1,NFE2L2,FCGR3A/FCGR3B,CCR1,SIGMAR1,UCP2,ENG,POLDIP2,FOS,NR4A2,NTRK3,NR4A1,PSAP,SOX9,ABCC3,ABCB6,PRKACB,SOCS3,TRAF3,DCUN1D5,SEPT9,MBP,FCER1A,CSNK1A1,NRN1,TYMP,HSPA5,CD28,HSPA4,PACS2,NUPR1,PPP1CA,CBR1,IL2RG,PCSK6,BAMBI,PFDN5,AURKAIP1,PPP1R11,KLF4,CAPN2,INSR,UBE2I,ETV5,RPSA,HSPB1,SCD,CARS,MSR1,DNASE1L3,BARD1,HDGF,IRAK1,HLA-G,CIAPIN1,EDN1,TIMP1,STAT1,ATP13A2,VCAM1,USMG5,NPY1R,SOD1,FGF1,KIFC3,APOB,NCSTN,HRAS,CXCL10,SGPL1,PIK3CG,ABCC1,TXN,HMGA1,MNT,ANGPTL1,DPH2,MBD4,SFRP1,TCF7,CYR61,GSTP1,ADAM17,UBQLN1,DUSP6,SLC1A3,HYOU1,KAZN,ASNS,UCHL1,LYZ,JUN,BANF1,ANXA5,TOP2A,SLC19A1,NACC1,FKBP5,PTPRK,TBC1D9,TYROBP,TRIM28,EGR1,APP,ITGB2,SREBF2,SBF1,PEA15,FCER1G,NCAM1,GAB2,SLC31A1,CCNI,CD4,UNC5B,ZNF91,TUBB,CTBP1,CAMK2D,PLCE1,DPP3,ITGAV,CYBB,POMP,GPC1,RET,BCKDK,PSMA6,MIF,SPP1,ANLN,PHB2,RAC1,PSMC4,SEL1L,OSTM1,IL1RN,ACKR3,MAPT,MAPK10,RARRES3,VDAC1,LEP,ATF5,PDGFA,ERN1,PKM,SLC7A1,SMPD1,HIF1A,PLPP1,FAS,CLCN4,HMOX1,HINT1,PARK7,FLNA,THBS1,DUSP10,VCP,TGFB2,POLN,KIT,PSMA3,SLC40A1,SELENOH,S100A8,MAPKAPK2,PRNP,PSMB4,MAPK9,CSF1R,THRSP,NDUFA13,ENO1,EPHB3,SLC1A2,PPP2R1B,P2RX7,SHMT2,RPL38	227	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of cytoskeleton	1.03E-09	Increased	4.087	bias	0.225	CRYAB,TGFBR1,AGER,PCLO,PIK3R1,C1QA,CXCL9,SLC9A1,CLIP1,AJUBA,GLB1,PLXNB2,KNSTRN,TMSB10/TMSB4X,TP53,LCP1,MTSS1,CARMIL1,MAD2L2,TPM3,FLOT1,FGFR2,LARP4,ARHGDIB,BTG2,GAPDH,ACTG1,RAP2A,APOE,NME1,FGF2,GDF15,ADIPOQ,CKAP4,SYNM,SHTN1,SORBS1,AMOT,S100A1,WDR36,FCGR2A,GNA12,ENG,CPEB4,MYO5A,GRN,FOS,MYOC,NTRK3,FLNC,KRT6A,ARHGDIA,SOX9,DCX,PRKACB,NCDN,YWHAH,SEPT9,ATP2B1,EML4,MBP,CSNK1A1,FCER1A,NRN1,NNMT,RHOG,HOXA7,CDC42EP1,CNTNAP1,PTPRQ,MAPK8IP2,RIMS4,DMTN,UBA6,CAPG,ARSA,MLST8,TXNRD1,SLC3A2,METRN,ADAM12,CAPN2,INSR,SIRPA,UBE2I,HSPB1,FLRT1,PHLDB2,HNRNPK,HDGF,EDN1,LOC102724428/SIK1,KLHL42,THBS4,MT-ND6,CAPZB,SLC9A3R1,TUBG1,DVL1,NQO1,SOD1,PDLIM4,GIT1,KIF3B,FGF1,KCTD13,KIFC3,CAPNS1,KIF5B,TTL,TBC1D7,ITSN1,ARPC5,ITGA8,SH3BGRL3,TOR1A,RAN,HRAS,KPNA1,MIEN1,CXCL10,DYNLL1,CTSS,ABR,ABCC1,KIF21A,AFAP1,KIF5C,TESK1,CAPN6,RIMS3,CFL1,CKAP2,NINJ1,PIP5K1C,STIP1,RTN4,ALDOA,SFRP1,CYR61,LCP2,BTG3,CDK16,TSGA10,SDC3,ENAH,UCHL1,DCLK2,JUN,SRGAP1,ACAP2,SNX10,TUB,NPTXR,CALML3,PTPRK,KRT6B,EGR1,APP,TENM4,TREM2,ADCY1,FKBP4,P2RY12,GABARAP,RUFY3,MAPRE3,NCAM1,PFN1,ARF1,MAP1B,UNC5B,SDC4,DYNLT1,TUBB,CFL2,COMT,ITGAV,NEO1,C1QBP,RET,RFLNB,SPP1,BMP2K,RAC1,RAB10,SIPA1L1,LMCD1,PREX1,MAPT,MAPK10,RARRES3,PLEK,ARL2,SPIRE1,LEP,RNF165,STMN2,EPB41L3,CD2,PDGFA,NLGN1,ERN1,VAPA,PKM,SMPD1,FAS,TNFRSF12A,PPP1R9B,FLNA,THBS1,ANXA1,TGFB2,KIT,NSMF,S100A8,ARHGEF2,MAPKAPK2,ACTN1,PRNP,MAPK9,F13A1,PLXND1,CSF1R,KIF2A,EPHB3,NCKAP1L,RTN3,P2RX7	229	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis	1.31E-09	Decreased	-2.371	bias	-0.527	APOE,GJB6,FGF2,ADIPOQ,SH3GLB1,CERS2,LAMP1,CLCN3,NFE2L2,ATP13A2,NDUFS4,ACP2,PSMC4,SOD1,ARSA,HAX1,APP,GRN,TREM2,MAPT,PPT1,CTSB,PSAP,CLCN7,SQSTM1,ESR2	26	
Neurological Disease, Psychological Disorders, Skeletal and Muscular Disorders	Parkinson's disease	Parkinson's disease	1.32E-09	 	 	 	 	TUBA1B,MT-TT,CRYAB,MBP,MAP1B,TOR1A,RAN,LDHB,SLC25A6,COMT,ATF4,CHCHD2,TUBA1C,TP53,SPP1,GPS2,FLOT1,ANXA2,ARHGDIB,TMEM55A,MAPT,RTN4,GSTP1,MT-TP,HSPB1,FTH1,PEBP1,SUMO3,APOE,RPS3A,CD74,RPS4X,FARSB,UCHL1,GBA,PARK7,LAMP1,ADORA1,RPL31,ATP13A2,PRNP,MT-ND6,CAPZB,RPL17,TRIB3,DNAJC1,SOD1,SNCG,APP,ATP6V1E1,FTL,MT-ND1,MT-ND5,NR4A2,TSPO,ADRA1A	56	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast cancer	breast cancer	1.45E-09	 	0.252	 	-0.006	CRYAB,TGFBR1,WHSC1,AGER,C1QTNF5,PIK3R1,COL8A1,KCMF1,CXCL9,CLIP1,ODC1,POR,IP6K3,CCND3,ARID3B,EIF3B,AJUBA,KEAP1,FRAS1,ATF4,MYBBP1A,MRPL24,TP53,SRPRA,PROSC,PPP1R1B,KCTD16,TNFRSF10B,FGFR2,BRF2,ARHGDIB,HAX1,NRBP1,CTSA,SCUBE1,BTG2,DUSP4,NHLH1,LYPLA1,ESR2,STEAP3,FTH1,EPHX1,BANK1,APOE,NME1,GADD45B,FGF2,HSPB8,ATRAID,COL16A1,SHTN1,RABL6,PTPRJ,TNXB,PLIN2,ATP5J2,FAM96B,ADORA1,HCAR2,NFE2L2,RPL4,TUBB4B,GNA12,SLC39A6,ENG,C1orf122,FOS,MT-ND1,AFF3,NR4A2,NTRK3,MAZ,NR4A1,KRT6A,ARHGDIA,SOX9,HAGH,YWHAH,AKR1C3,SEPT9,FCER1A,NME2,TYMP,CTSD,KRTAP4-6,CYP3A5,CXCL14,TUBA1C,CDC42EP1,MUCL1,ADAMTS5,PFKFB3,IL2RG,PCSK6,MT-TE,FYB,KLF4,FOSB,PIK3R3,ADAM12,CCDC43,RBX1,UHRF1BP1L,INSR,KCTD19,MEGF8,CBX3,TFPT,HSPB1,PLGRKT,MECR,BARD1,DMD,COL6A6,HLA-G,ALDH2,EDN1,TIMP1,LOC102724428/SIK1,RHOBTB2,IGSF8,CFH,STAT1,LONP1,KRT14,MT-CO1,AKR1C1/AKR1C2,SLC9A3R1,NPY1R,TUBG1,NQO1,HPS1,SOD1,PDLIM4,S100A2,NFE2L1,FGF1,CLGN,LGALS2,CXXC5,SLC25A5,TUBA1B,THEMIS2,CPAMD8,APOB,ITSN1,SRP19,HRAS,MKI67,GLO1,MIEN1,CECR1,CXCL10,BCAT1,FAM91A1,MPV17L2,ABR,ABCC1,PIK3CG,WNT5B,TUBB2A,FARSA,DPH2,CCND2,CD68,C19orf53,MS4A4A,RTN4,ALDOA,ARHGAP35,GLUL,KRTAP4-4,SFRP1,AIDA,TCF7,CYR61,MYEOV,GSTP1,HIST1H1C,ADAM17,HLA-A,UBQLN1,CDK16,XPOT,FKBP1A,PFKL,H2AFZ,TAX1BP3,ENAH,PIP,FANCE,RPL35,CES1,JUN,GBA,MT-CYB,TOP2A,TRIM16,TUB,TPO,FKBP5,GJB2,PLOD3,LIMCH1,RPS24,RPS19,NAP1L4,LETM1,ADRM1,KRT6B,TBC1D9,EGR1,SLIRP,MT-ND4,KRT5,ATXN2L,COPS3,PLA2G2A,EIF3G,CALM1 (includes others),FIS1,COL5A3,SREBF2,CYCS,DVL3,CBX4,MAPRE3,GAB2,MT-TT,PFN1,CD4,LHCGR,UTP4,TUBB,UBA2,MTCH2,GSPT1,CNDP2,SLC25A6,DPP3,COMT,ITGAV,RPL19,KPNA2,SIAH2,C1QBP,RET,EIF2AK1,MIF,SPP1,GSDMB,LAGE3,PSMC4,MARS,PKN1,FMN2,MAPK10,AKR1B1,ATF5,PRDX5,PDGFA,PCDH19,PKM,SLC7A1,HIF1A,FAS,HMOX1,THBS1,FLNA,NDUFC2,ANXA1,VCP,TGFB2,KIT,ARHGEF2,CCDC73,SLC40A1,S100A8,MAPKAPK2,ALPL,HMGCS1,NDUFAF3,NACA,PSMB4,SCN2A,ADCY2,TAF6,TPST2,QSOX1,GUK1,CSF1R,THRSP,ENO1,MT-ND5,CLDN1,UBA1,C6,PPP2R1B,SHMT2	300	
Nucleic Acid Metabolism, Small Molecule Biochemistry	biosynthesis	biosynthesis of purine ribonucleotide	1.59E-09	Increased	2.536	bias	0.744	SOCS3,ATP5G1,AGER,CHCHD10,ATP5D,PKM,HIF1A,FAS,NNMT,AK1,G0S2,UQCC2,VCP,MT-CO3,LONP1,TP53,MT-ATP6,UCP2,LETM1,USMG5,SURF1,SOD1,APP,MAPT,ALDOA,CYCS,INSR,SLC25A5,VDAC1	29	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	malignant solid tumor	1.97E-09	 	0.107	 	0.300	TGFBR1,PCLO,ASS1,C1QTNF5,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,ANXA2,LARP4,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,UTP18,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,SCNN1B,ALPK2,AMOT,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,HS6ST1,LHFPL2,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,MT-ND2,NSMAF,GUF1,PIK3R3,SPINK5,RBX1,CCDC43,NAGLU,TMX2,INSR,KCTD19,NDUFS3,CBX3,POLD2,FAM134A,ETV5,SCD,SUMO3,FOXRED2,CARS,FLRT1,FAT3,NHP2,RPL7A,C20orf24,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,RNF26,SNTB1,TCEA3,PYGB,SOD1,SAA2,DHX8,SNX27,VAT1,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,C15orf59,RPLP0,TUBA1B,GFPT1,SNTA1,ITGA8,HLA-DQB1,GLO1,MIEN1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,SFT2D2,UBXN6,COMMD9,KAZALD1,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SCRN1,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,ASTE1,COASY,SDC3,ATP6AP1,H2AFZ,RNF185,MAFG,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,ACVR1C,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,CD209,NAP1L4,RRP1B,ANKRD9,EGR1,TRIM28,COPS3,STS,PSMD8,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,PNO1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,GOT1,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,LAGE3,ANKMY2,FAM45A,RPL12,ATP10A,SLC39A3,GALNT13,TARS,ATP6V1A,TPSAB1/TPSB2,PREX1,TMEM189,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,MPEG1,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,RPS21,KIFAP3,THRSP,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,RRM2B,CA5B,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,SLCO2B1,MRPL24,DPT,PLD3,LHPP,ICT1,MTSS1,KLHL25,PAQR3,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,ZNF69,CD52,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,GJB6,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,ATRAID,SDHAF1,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,DCUN1D5,BZW2,TRAF3,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,RNASE1,TYMP,IMP4,CES2,SLC35F6,BIN1,CEBPG,NNMT,CD28,TMEM132C,SAE1,CYP3A5,RPS13,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,MUCL1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,UBA6,ARSA,MT-ND4L,GYS2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,ME1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,ATP6V1E1,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,SPCS1,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,ARRDC4,CSRP2,STOML2,TSPAN33,PDE1C,SERINC2,PSMB2,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,MT-ND3,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,PSMB10,BCO2,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,TAX1BP3,CA3,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,LAMP1,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,ADCK2,PEA15,PRMT5,P2RY12,CYCS,DNPH1,SCAMP3,RUFY3,MAPRE3,GPR137,HOXB5,MVD,GAB2,CLTB,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,LMO4,GPS2,ANLN,GLYAT,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,PRDX5,PDGFA,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,FAU,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,TMEM184B,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,EIF3B,ATG9A,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,LAIR1,SURF1,IRF5,CTSB,C15orf39,NHLH1,PLTP,FTH1,EPHX1,CD163L1,EVA1B,GADD45B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,IGKC,SLC25A1,ENG,MAGEC3,CSTB,MYO5A,RPS16,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,UBE2I,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,FARS2,KLHL42,STAT1,MT-CO1,THBS4,PREB,TRIM55,IPO4,G6PD,CSRNP1,TSN,KIF3B,APOLD1,APLP2,CPAMD8,THEMIS2,ARPC5,RAN,SRP19,GHITM,DDX20,MKI67,GSS,EEF1D,HPCAL1,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,SSBP1,C19orf53,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,DHRSX,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ASNS,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,MYL12A,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,SLIRP,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,SLC48A1,CCDC85B,GLIS2,RNF144A,BRINP2,RHBDD2,TREM2,USP22,APOL4,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,UBE2A,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,C1QBP,RILP,HIST1H4H,RET,MDH2,BCKDK,LANCL1,C7orf50,MRPS15,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PACSIN3,TRIOBP,GSDMB,XYLT1,GNG2,HSPA9,TALDO1,RAC1,CPVL,HIST1H2BK,GPAA1,RASD1,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,PLEK,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,SH3RF3,CNRIP1,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,TBCB,RRAGD,OAZ1,FMO1,WSB2,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,IL20RB,KIAA1683,ACSM2B,PLBD2,TMEM2,APOC1,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,KEAP1,MCOLN3,FRAS1,ST6GALNAC2,ATF4,SCPEP1,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TSPYL5,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,TPM3,BRF2,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,PRELP,GAPDH,UCK1,MARCH4,TULP3,LYPLA1,TMEM33,STEAP3,PPDPF,RAP2A,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,CD74,ZNF827,SLC35B2,GLIPR1,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,LURAP1L,TTC23,FAM96B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,WDR36,TMC2,SRA1,ALOX5AP,TRIB3,HSPA2,SPTLC3,GRN,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,SEMA3C,TSC22D2,TTYH3,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,HSPA4,KRTAP4-6,RHOG,ZNRF3,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,C17orf53,CHMP1A,CBR1,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,MT-TE,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,CDH20,SLC25A39,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,CD151,RPSA,DOK5,ATP6V0C,UBXN1,SYCE1,SF3B5,MSR1,DMD,IL17RA,PDGFC,NDUFA2,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,CXCL16,CISD1,SHB,CIDEA,KIFC3,LGALS2,KIF5B,TTL,EIF3I,C1orf226,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,PLIN1,APOB,ITSN1,AHCYL1,C9orf72,TOR1A,TXNL4A,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,NANOS1,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,PTPA,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,MS4A6A,TCEA1,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,S100A7,PIP,FANCE,UCHL1,RPL35,SEC61A1,ACSM5,GBA,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,CALML3,SLC7A6,NDUFS4,MBOAT7,ADRM1,LETM1,TYROBP,TBC1D9,MT-ND4,KRT5,APP,AREL1,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,GABARAP,ACTR1A,EFR3A,MT-TT,SLC7A11,ATP5D,XPO5,RAB9A,UTP4,MMRN1,TAF10,SDC4,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,NARS,PGD,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,PKM,CUTA,VAPA,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,ERV3-1,TNFRSF12A,SEPHS2,HMOX1,RNF167,PCK2,KCNMA1,NDUFC2,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,CTDNEP1,STK40,HMGCS1,ACTN1,PRNP,NDUFAF3,NACA,COX17,TAF6,CD160,VANGL1,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1394	
Free Radical Scavenging, Molecular Transport	quantity	quantity of reactive oxygen species	2.14E-09	 	-1.964	 	-1.481	APOE,LEP,APOB,PFN1,PRDX5,OSGIN1,UBQLN1,ADIPOQ,HRAS,SMPD1,FAS,CERS2,CD28,CA3,HMOX1,HSPA4,PGD,JUN,PARK7,EDN1,KEAP1,PIK3CG,CYBB,CYGB,TXN,MAPKAPK2,NDUFAB1,LONP1,NFE2L2,PRNP,TP53,EIF2AK1,UCP2,NQO1,HSPA9,G6PD,RAC1,SOD1,HMGA1,CSF1R,NFE2L1,APP,FTH1	43	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of neutrophils	2.80E-09	Increased	2.405	bias	-0.026	SOCS3,PLCB2,AGER,UNC5B,CTSG,CXCL10,CD28,RSPO3,PIK3CG,CXCL14,CYBB,TXN,C1QBP,TMSB10/TMSB4X,TP53,PTX3,SPP1,RAC1,FLOT1,CAPG,TPSAB1/TPSB2,PREX1,IL1RN,PIP5K1C,RTN4,CTSB,CD14,PLTP,SFRP1,C3AR1,HSPB1,CD151,APOE,ADAM17,DAPK2,ADIPOQ,CD74,IL17RA,FAS,HMOX1,EDN1,TIMP1,ANXA1,SAA1,TGFB2,S100A8,STIM1,CFH,ADORA1,MAPKAPK2,GJB2,CCR1,THBS4,VCAM1,FCGR2A,NQO1,MAPK9,ALOX5AP,APP,GRN,ITGB2,MT-ND1,FCER1G,NCKAP1L	64	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of osteosarcoma cells	3.05E-09	Decreased	-5.303	bias	 	PNO1,RAN,RPL7A,RPL35,EIF3B,RPS13,VCP,RPL19,PSMA3,ISCU,RPS12,RPS5,RPL31,NAPA,RPS24,TP53,RPS19,CAPN6,PSMA6,HSPA9,PSMC4,RPS21,RPL37A,RPS29,FAU,EIF3G,RPS16,PSMA4,RPS15A,RPL37,RPLP0,RPL38,UBE2I	33	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function	proliferation	proliferation of fibroblast cell lines	3.32E-09	Increased	2.546	 	0.676	ICMT,ITSN1,AGER,PIK3R1,HRAS,NRN1,CES2,SDC4,EEF1D,ODC1,CXCL10,CTSD,PLCE1,EIF3B,ATG9A,CXCL14,RET,TP53,EIF2AK1,PFKFB3,MIF,RHEB,MAD2L2,RAC1,FGFR2,TPM3,PFDN5,HMGA1,SLC3A2,MNT,ACKR3,PIP5K1C,STIP1,BTG2,PSMA4,MAPK10,ALDOA,INSR,AKR1B1,SIRPA,PIM3,GADD45B,LEP,FGF2,PDGFA,BTG3,PKM,HSPB8,ADIPOQ,HDGF,HMOX1,HINT1,JUN,THBS1,KIT,CYGB,MAPKAPK2,STAT1,CIZ1,MCRS1,TAF6,NPY1R,EGR1,GNA12,G6PD,LZTS2,MAPK9,TSN,CSF1R,ATIC,FGF1,GRN,FOS,SOX6,NTRK3,SBF1,CDC14B,RNF187,EIF3I,SOX9,CBX4,PPIL1,ADRA1A	83	
Infectious Diseases	infection	Viral Infection	3.35E-09	Increased	7.297	bias	1.811	CRYAB,TGFBR1,PIK3R1,CXCL9,PANX1,POR,PTPRC,GATAD2A,ATF4,HIST1H2AC,MGAT1,TP53,FBL,TNFRSF10B,FGFR2,ANXA2,IRF5,TRAPPC1,ARHGDIB,NRBP1,TMEM127,BTG2,CTSB,GAPDH,ATOX1,APOE,GBP1,ARPC1B,DDIT3,DAPK2,ADIPOQ,LGALS9,PPIA,ATRAID,TECR,CD74,OGT,PTPRJ,ANKRD53,ADORA1,FCGR3A/FCGR3B,G3BP2,S100A1,CCR1,SIGMAR1,FCGR2A,TUBB4B,IGKC,RPS10,DGAT2,PSMB6,ISG15,RPS16,ADRA1A,SOCS3,TRAF3,CCT2,TLR8,AP1B1,HSPA5,CD28,HSPA4,TMEM132C,SAE1,HSF4,CYP3A5,RPS13,HOXA7,STAB1,TUBA1C,CHMP1A,ADAMTS5,TOP3B,STXBP1,IL2RG,STK39,GM2A,MAPK8IP2,PCSK6,RIMS4,POLR2K,AES,SDCBP,EDEM1,NDUFA6,INSR,RPSA,ATP6V0C,MSR1,IL17RA,PDGFC,HNRNPK,C20orf24,TIMP1,LOC102724428/SIK1,RNH1,STAT1,LONP1,TRIM55,SLC9A3R1,RNF26,TUBG1,DVL1,PSMD2,EIF3I,UBE2E2,MAP4K4,SPCS1,APOB,RAB5C,AHCYL1,TXNL4A,RAN,HRAS,HLA-DQB1,CXCL10,SGPL1,CTSS,GAA,CHCHD2,TXN,POLR2I,SNRPA,CAPN6,TUBB2A,AASS,HMGA1,SPON2,PIP5K1C,MS4A4A,STIP1,IL10RA,GLUL,C3AR1,LCP2,HIST1H1C,FCGRT,RAB32,ATP6V0B,LAPTM5,HLA-A,SRD5A1,FKBP1A,COASY,PFKL,ATP6AP1,DCLK2,RPL35,JUN,MT-CYB,ANXA5,TOP2A,SNX10,PSMD14,RPS5,RPL18,PI4KA,PLOD3,CD209,SIGLEC1,ANKRD9,TYROBP,EGR1,LRRC8D,APP,AIP,EIF3G,PI3,ITGB2,FTL,LAMP2,SNRPC,PDIA6,RNF144A,SREBF2,BRINP2,PIGK,C6orf48,CYCS,GABARAP,GAB2,PLCB2,SLC31A1,ARF1,CD4,PRMT3,RPS23,CLTB,RAB9A,TUBB,CD63,CTBP1,ITGAV,CYBB,SNU13,PTX3,PRKRA,MIF,SPP1,PACSIN3,BMP2K,SNRPF,TALDO1,HSPA9,RAC1,PSMC4,HIST1H2BK,RPL12,CYSTM1,ATP6V1A,TPSAB1/TPSB2,IL1RN,SH2B3,CD14,RARRES3,UBE2E1,LEP,ATF5,ERN1,GANAB,NAA10,RRAGD,FAS,SSU72,HMOX1,FLNA,ANXA1,VCP,TGFB2,PSMA3,S100A8,HMGCS1,RAB8B,ACTN1,NDUFAF3,PRNP,DLGAP4,AP3D1,RAB7A,F13A1,KCNJ3,PLXND1,FAU,STT3A,APOC1,PANK3,PDE8B,VAMP8,MAT2A,RTN3,P2RX7,ATP6V1B2,RPL38	253	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities	hereditary neuropathy	hereditary neuropathy	3.40E-09	 	 	 	 	APOE,LITAF,PFN1,C9orf72,CHCHD10,SEPT9,C1QTNF5,GARS,HSPB8,UCHL1,PARK7,MT-CYB,MT-CO3,CHCHD2,MTMR2,MT-ND2,ATP13A2,HK1,MT-CO1,SIGMAR1,MT-ND6,MT-ATP6,SPG21,SURF1,RAB7A,MT-ND4,SOD1,MT-ND4L,MARS,CISD2,GRN,MT-ND5,MT-ND1,NR4A2,SBF1,YARS,MAPT,NAGLU,SLC1A2,PSAP,AARS,MT-ND3,SQSTM1,UBA1,HSPB1	45	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities	cell death	cell death of malignant tumor	3.82E-09	Decreased	-3.230	 	-2.088	PNO1,GAB2,SOCS3,TGFBR1,PIK3R1,RAN,CD28,EIF3B,RPS13,KEAP1,RPL19,ITGAV,HOXA7,TXN,NAPA,TP53,MIF,CAPN6,PSMA6,LAIR1,TNFRSF10B,HSPA9,RAC1,PSMC4,MAD2L2,RPL37A,IRF5,RTN4,CTSB,PSMA4,RPS15A,SFRP1,CYR61,LYPLA1,UBE2I,LEP,RPS3A,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,CD74,HIF1A,RPL7A,FAS,HMOX1,RPL35,JUN,ANXA1,VCP,KIT,PSMA3,ISCU,RPS12,RPS5,NFE2L2,RPL31,RPS24,PRNP,RPS19,VCAM1,CD160,RPS21,SOD1,RPS29,FAU,APP,EIF3G,FOS,ENO1,NR4A2,RPS16,NR4A1,RPL37,RPLP0,RPL38	78	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of phagocytes	3.90E-09	 	1.391	 	0.095	APOE,PFN1,DDIT3,FGF2,CTSG,IL17RA,FAS,CXCL10,CD28,HMOX1,EDN1,TIMP1,THBS1,ANXA1,KIT,S100A8,STAT1,FCGR3A/FCGR3B,NLRC4,CCR1,PTX3,MIF,VCAM1,SPP1,TYROBP,FCGR2A,EGR1,FGFR2,SOD1,IRF5,FGF1,GRN,ITGB2,IL1RN,ACKR3,NR4A1,C6	37	
Hereditary Disorder, Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities	hereditary optic atrophy	hereditary optic atrophy	4.06E-09	 	 	 	 	MT-CO1,MT-ND6,MT-ND5,MT-ATP6,MT-ND1,MT-CYB,MT-CO3,MT-ND4,MT-ND3,MT-ND2,MT-ND4L,CISD2	12	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities	cell death	cell death of tumor	4.88E-09	Decreased	-3.979	 	-2.989	PNO1,GAB2,SOCS3,CRYAB,SLC7A11,TGFBR1,PIK3R1,RAN,HRAS,CD28,CCND3,EIF3B,RPS13,KEAP1,RPL19,ITGAV,HOXA7,TXN,NAPA,TP53,MIF,CAPN6,PSMA6,LAIR1,TNFRSF10B,HSPA9,RAC1,PSMC4,MAD2L2,ANXA2,RPL37A,IRF5,ANGPTL1,ADAM12,PSMA4,RTN4,CTSB,RPS15A,SFRP1,INSR,CYR61,LYPLA1,UBE2I,PIM3,LEP,RPS3A,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,HIF1A,CD74,RPL7A,FAS,HMOX1,RPL35,JUN,TIMP1,ANXA1,VCP,KIT,PSMA3,ISCU,RPS12,RPS5,NFE2L2,RPL31,PRNP,RPS24,RPS19,VCAM1,CD160,MAPK9,RPS21,SOD1,RPS29,FAU,APP,EIF3G,FOS,ENO1,RPS16,NR4A2,NR4A1,CYCS,RPL37,RPLP0,RPL38	90	
Dermatological Diseases and Conditions, Immunological Disease, Inflammatory Disease, Inflammatory Response	atopic dermatitis	atopic dermatitis	5.16E-09	 	 	 	 	PER1,PLIN1,FCER1A,STARD7,MKI67,CXCL9,LGMN,IFI30,MUCL1,NAPA,CBR1,TRIOBP,CFL1,MAD2L2,TPM3,CPVL,FLOT1,CAPG,BRF2,MYL9,MNT,SPINK5,IL1RN,CST6,UBE2I,S100A11,ADAM17,CD2,ADIPOQ,HLA-DQA1,FKBP1A,SMPD1,CD74,S100A7,JUN,FLNA,TIMP1,ANXA5,DUSP10,ANXA1,HLA-DRA,VCP,S100A8,STAT1,KRT10,P4HA2,CAPZB,KRT5,S100A2,ENO1,NR4A2,FCER1G,FKBP4,MS4A2,KRT6A,PSAP	56	
Protein Degradation, Protein Synthesis	catabolism	catabolism of protein	5.38E-09	Increased	2.392	bias	0.403	SPCS1,CSTA,CRYAB,PIK3R1,CTSG,NCSTN,SH3GLB1,ODC1,SNX12,PTPRC,LGMN,CTSS,GPR26,TP53,MAD2L2,CPA3,RHBDD1,DSG1,HSPA8,CTSA,CTSB,GAPDH,SFRP1,SQSTM1,APOE,ADAM17,DPM2,ADIPOQ,PIP,UCHL1,OGT,GBA,UBE2K,AAK1,LAMP1,PSMD14,ASPH,AMFR,ADRM1,PSMD8,CSTB,APP,HIST1H1B,LAMP2,DERL1,TPP1,SOX9,DVL3,SOCS3,TRAF3,PFN1,CMA1,CCT2,SDC4,HSPA5,CTSD,CNDP2,ZNRF3,DPP3,IFI30,CCT5,SIAH2,RILP,DPM3,CHMP1A,VPS11,STXBP1,PCSK6,PHB2,PSMC4,AURKAIP1,UBA6,SEL1L,UBE2D2,SPINK5,ADAM12,IL1RN,UBE2G1,EDEM1,FMN2,NAGLU,CAPN2,HTRA1,UBE2E1,UBE2I,UBXN1,RNF165,MAN1B1,FAS,PARK7,FLNA,TRABD2A,VCP,OAZ1,LONP1,ATP13A2,NACA,DVL1,RAB7A,DNAJC1,SOD1,NDUFA13,SERPINE2,CAPNS1,PSMD2,P2RX7,UBE2D3	107	
Cellular Function and Maintenance	engulfment	engulfment of cells	5.61E-09	Increased	5.817	bias	2.002	GAB2,RAB5C,TGFBR1,PFN1,ITSN1,AGER,ARF1,CD4,MAP1B,C1QA,BIN1,CD63,CLIP1,SNX12,PTPRC,CXCL10,RHOG,ABR,ITGAV,CLCN3,ADAMTS5,GULP1,TP53,EIF2AK1,PTX3,MIF,RAC1,FGFR2,SYP,FLOT1,CAPG,HAX1,AP2S1,HSPA8,PIP5K1C,MS4A4A,CD14,SIRPA,ATP6V0C,APOE,LEP,MSR1,CUBN,HYOU1,FAT3,ADIPOQ,SMPD1,ATP6AP1,FAS,HMOX1,PTPRJ,THBS1,MT-CYB,ANXA1,ANXA5,SAA1,TUB,DAB2,STIM1,ADORA1,MAPKAPK2,FCGR3A/FCGR3B,SIGLEC1,CD209,SRA1,UCP2,FCGR2A,RAB7A,STON1,RPS21,ISG15,APP,ATP6V1E1,ITGB2,ATP6V1F,TREM2,PPT1,FCER1G,VAMP8,P2RX7,ATP6V1B2	81	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of cancer cells	5.97E-09	Decreased	-3.230	 	-2.088	PNO1,GAB2,SOCS3,PIK3R1,RAN,CD28,EIF3B,RPS13,KEAP1,RPL19,ITGAV,HOXA7,TXN,NAPA,TP53,MIF,CAPN6,PSMA6,LAIR1,TNFRSF10B,HSPA9,RAC1,PSMC4,MAD2L2,RPL37A,IRF5,RTN4,CTSB,PSMA4,RPS15A,SFRP1,CYR61,LYPLA1,UBE2I,LEP,RPS3A,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,CD74,HIF1A,RPL7A,FAS,HMOX1,RPL35,JUN,ANXA1,VCP,KIT,PSMA3,ISCU,RPS12,RPS5,NFE2L2,RPL31,RPS24,PRNP,RPS19,VCAM1,CD160,RPS21,SOD1,RPS29,FAU,APP,EIF3G,ENO1,FOS,NR4A2,RPS16,NR4A1,RPL37,RPLP0,RPL38	77	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	cell death	cell death of tumor cells	6.40E-09	Decreased	-3.979	 	-2.976	PNO1,GAB2,SOCS3,SLC7A11,PIK3R1,RAN,HRAS,CD28,EIF3B,CCND3,RPS13,KEAP1,RPL19,ITGAV,HOXA7,TXN,NAPA,TP53,MIF,CAPN6,PSMA6,LAIR1,TNFRSF10B,HSPA9,RAC1,PSMC4,MAD2L2,ANXA2,RPL37A,IRF5,ANGPTL1,ADAM12,PSMA4,RTN4,CTSB,RPS15A,SFRP1,INSR,CYR61,LYPLA1,UBE2I,PIM3,LEP,RPS3A,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,HIF1A,CD74,RPL7A,FAS,HMOX1,RPL35,JUN,TIMP1,ANXA1,VCP,KIT,PSMA3,ISCU,RPS12,RPS5,NFE2L2,RPL31,PRNP,RPS24,RPS19,VCAM1,CD160,MAPK9,RPS21,SOD1,RPS29,FAU,APP,EIF3G,FOS,ENO1,RPS16,NR4A2,NR4A1,CYCS,RPL37,RPLP0,RPL38	88	
Drug Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of glutathione	6.66E-09	 	0.928	 	0.223	TP53,LEP,DDIT3,AGER,TALDO1,PKM,G6PD,SLC1A3,FGFR2,SOD1,NFE2L1,CERS2,APP,ALDH2,KEAP1,ABCC1,CXCL14,ATF4,STIM1,SELENOH,GCLM,TXN,NFE2L2,UNG,FTH1	25	
Neurological Disease, Psychological Disorders	tauopathy	tauopathy	6.89E-09	 	 	 	 	AGER,PIK3R1,RAN,NCSTN,MT-CO2,ADGRL1,CXCL10,LGMN,CTSS,ATF4,TXN,UNG,TP53,SNRPA,PLD3,TUBB2A,PPTC7,LARP4,HMGA1,CD68,MS4A4A,STIP1,CTSB,GAPDH,PLTP,ESR2,APOE,MS4A6A,DDIT3,UBQLN1,FGF2,SLC1A3,CD74,S100A7,UCHL1,JUN,MT-CO3,NFE2L2,FCGR3A/FCGR3B,ALDH5A1,FCGR2A,TUBB4B,TYROBP,IGKC,PLA2G2A,APP,FIS1,MT-ND1,NR4A2,NTRK3,SREBF2,PSAP,TSPO,DCX,ADRA1A,PRKACB,GAB2,TUBB,HSPA5,BIN1,CTSD,PACS2,TUBA1C,GM2A,HSPA9,HNRNPAB,SYP,EPRS,PREX1,ADAM12,MAPT,SLC7A2,MAPK10,CD14,INSR,HTRA1,DOK5,SCD,LEP,SLC1A4,SMPD1,HIF1A,MT-TN,ALDH2,HMOX1,PARK7,BCYRN1,TIMP1,SENP3,IGSF8,PRNP,MT-CO1,SCN2A,TUBG1,NQO1,MAPK9,SOD1,SERPINE2,CXCL16,TMEM2,APLP2,APOC1,SLC1A2,RTN3	104	
Cellular Movement	cellular infiltration	cellular infiltration of blood cells	7.90E-09	 	0.718	 	-0.093	SOCS3,PLCB2,CRYAB,TGFBR1,AGER,CMA1,PIK3R1,UNC5B,CTSG,HRAS,CXCL9,CXCL10,CD28,RSPO3,PIK3CG,CYBB,ZBTB16,TP53,PTX3,MIF,SPP1,NINJ1,EFS,PREX1,IL1RN,CTSB,CD14,SFRP1,PLTP,CYR61,AKR1B1,ESR2,C3AR1,HSPB1,APOE,ADAM17,LEP,MSR1,CD2,HLA-A,HYOU1,ADIPOQ,PPIA,HIF1A,IL17RA,FAS,HMOX1,CES1,GBA,EDN1,TIMP1,THBS1,ANXA1,DUSP10,SAA1,S100A8,STIM1,CFH,STAT1,MAPKAPK2,NFE2L2,KRT10,GJB2,CCR1,VCAM1,UCP2,NQO1,TRPA1,ALOX5AP,CSF1R,APP,CXCL16,ITGB2,GLIS2,FCER1G,NR4A1,C6,P2RX7	78	
Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology	necrosis	necrosis of tumor	8.73E-09	Decreased	-3.979	 	-2.976	PNO1,GAB2,SOCS3,CRYAB,SLC7A11,PIK3R1,RAN,HRAS,CD28,CCND3,EIF3B,RPS13,KEAP1,RPL19,ITGAV,HOXA7,TXN,NAPA,TP53,MIF,CAPN6,PSMA6,LAIR1,TNFRSF10B,HSPA9,RAC1,PSMC4,MAD2L2,ANXA2,RPL37A,IRF5,ANGPTL1,ADAM12,PSMA4,RTN4,CTSB,RPS15A,SFRP1,INSR,CYR61,LYPLA1,UBE2I,PIM3,LEP,RPS3A,DDIT3,FGF2,GDF15,ADIPOQ,HSPB8,LGALS9,HIF1A,CD74,RPL7A,FAS,HMOX1,RPL35,JUN,TIMP1,ANXA1,VCP,KIT,PSMA3,ISCU,RPS12,RPS5,NFE2L2,RPL31,PRNP,RPS24,RPS19,VCAM1,CD160,MAPK9,RPS21,SOD1,RPS29,FAU,APP,EIF3G,FOS,ENO1,RPS16,NR4A2,NR4A1,CYCS,RPL37,RPLP0,RPL38	89	
Cellular Compromise, Lipid Metabolism, Small Molecule Biochemistry	peroxidation	peroxidation of lipid	9.83E-09	 	-0.192	 	0.486	TP53,SCD,APOE,APOB,LEP,FGFR2,MAPK9,SOD1,IRAK1,CERS2,APP,HMOX1,FTL,MAPT,CYGB,INSR,CFH,C3AR1,CYP4A11,NFE2L2,PRNP	21	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of lipid	1.19E-08	Increased	3.087	bias	-0.175	PLIN1,APOB,PMVK,AGER,PIK3R1,VAC14,SH3GLB1,DDX20,ODC1,CXCL10,POR,SGPL1,ABCC1,PIK3CG,PLIN5,TXN,TP53,CERS6,ATP5J,YWHAG,PLAA,HSPA8,SERINC2,NR1D1,PIP5K1C,ME2,PLTP,B3GNT5,ESR2,APOE,SRD5A1,FGF2,GDF15,DPM2,SLC1A3,ADIPOQ,TECR,CD74,CES1,GBA,SORBS1,MT-CYB,PLIN2,DAB2,PI4KA,CD209,FCGR2A,EGR1,DGAT2,AGPAT1,ALOX5AP,TRIB3,SPTLC3,PLA2G2A,STS,APP,MYO5A,FOS,ITGB2,NR4A2,SREBF2,FCER1G,NR4A1,TSPO,NR5A2,NPC2,NCAM1,MVD,SOCS3,AKR1C3,ARF1,CD4,LHCGR,FCER1A,CERS2,PGD,PLCE1,HOXA10,MTMR2,GPC1,DPM3,NSMAF,PTX3,MIF,ACSL3,RAC1,ARSA,GPAA1,IL1RN,MPDU1,MAPK10,CD14,AKR1B1,CYP4A11,CNBP,IGFBP4,SCD,LEP,PDGFA,PKM,CD83,SMPD1,ME1,FAS,TNFRSF12A,HMOX1,PARK7,EDN1,ANXA1,KIT,CTDNEP1,PRNP,AKR1C1/AKR1C2,SLC9A3R1,G6PD,MAPK9,SOD1,THRSP,DEGS1,FGF1,SERPINE2,GIPR,APOC1,PDE8B,P2RX7	125	
Free Radical Scavenging	production	production of reactive oxygen species	1.28E-08	 	1.407	 	0.140	TRAF3,AGER,PIK3R1,CTSG,FCER1A,HRAS,TMBIM6,CXCL9,CD28,PIK3CG,ALDH3A2,ABCC1,CYBB,MT-ND2,TP53,HK1,SPP1,HSPA9,RAC1,ARSA,CD52,ARHGDIB,TXNRD1,MAPT,PRELID1,RTN4,CD14,SQSTM1,INSR,VDAC1,AKR1B1,ESR2,LCP2,FTH1,APOE,LEP,MSR1,DDIT3,UBQLN1,FGF2,ADIPOQ,PPIA,SMPD1,HNRNPK,FAS,HMOX1,PARK7,EDN1,ANXA1,S100A8,LONP1,NFE2L2,FCGR3A/FCGR3B,NLRC4,PRNP,MT-CO1,SIGMAR1,VCAM1,MT-ND6,LETM1,UCP2,TYROBP,FCGR2A,G6PD,SOD1,APP,GRN,ITGB2,FTL,NR4A1,ARHGDIA,P2RX7	72	
Neurological Disease	neurodegeneration	Neurodegeneration	1.37E-08	Decreased	-3.278	bias	-0.233	VAC14,SLC9A1,CERS2,CTSD,GLB1,CYBB,NMNAT2,MTMR2,RET,LANCL1,CLCN3,UNG,TP53,STXBP1,PTPRQ,ASNA1,FGFR2,ARSA,IL1RN,MAPT,CTSB,GAPDH,NAGLU,CLCN7,SQSTM1,ESR2,APOE,UBQLN1,FGF2,ADIPOQ,SLC1A3,SMPD1,HIF1A,MAFG,UCHL1,JUN,GBA,PARK7,KCNMA1,TGFB2,TUB,STAT1,ADORA1,NFE2L2,NDUFS4,PRNP,TYROBP,SOD1,CISD2,CSF1R,KCNQ4,NFE2L1,APP,FGF1,GRN,FTL,NR4A2,NTRK3,PPT1,TPP1,PSAP,SLC1A2,C6,NCAM1	64	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function	activation	activation of blood cells	1.47E-08	Increased	3.822	bias	1.048	AGER,MAF,CTSG,C1QA,HLA-DQB1,CXCL9,CXCL10,PTPRC,ZBTB7B,CTSS,PIK3CG,TP53,LAIR1,TNFRSF10B,ANXA2,IRF5,SPON2,SFRP1,C3AR1,LCP2,BANK1,APOE,RAB32,GJB6,LAPTM5,DDIT3,HLA-A,HLA-DQA1,HYOU1,ADIPOQ,HSPB8,LGALS9,PPIA,FKBP1A,CD74,S100A7,IGHG3,PTPRJ,HLA-DRA,STIM1,TPO,ADORA1,NFE2L2,FCGR3A/FCGR3B,CD209,SIGLEC1,TYROBP,FCGR2A,PLA2G2A,APP,AIP,GRN,FOS,ITGB2,PSME1,TREM2,PPT1,FCER1G,P2RY12,TRAF3,CD4,MBP,TLR8,STARD7,CD63,CD28,HSPA4,ITGAV,CYBB,RET,TBC1D10C,MIF,IL2RG,SPP1,BMP2K,RAB10,KLF4,TPSAB1/TPSB2,OSTM1,PREX1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,PLEK,SIRPA,LEP,TOLLIP,MSR1,CD2,F2RL3,PDGFA,SMPD1,CD83,HIF1A,PLPP1,FAS,IRAK1,TNFRSF12A,HLA-G,HMOX1,EDN1,PPP1R9B,THBS1,ANXA1,DUSP10,SAA1,KIT,S100A8,CFH,STAT1,RAB8B,PRNP,VCAM1,NPY1R,HSPH1,AP3D1,HPS1,MAPK9,SOD1,IL20RB,CSF1R,FGF1,SERPINE2,PAG1,VAMP8,C6,P2RX7	129	
Cancer, Organismal Injury and Abnormalities	tumorigenesis	tumorigenesis of tissue	1.53E-08	 	-0.641	 	-0.308	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,TMEM123,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,ST20,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,LHFPL2,HS6ST1,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,MT-ND2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,RBX1,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,VAT1,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,C15orf59,RPLP0,TUBA1B,GFPT1,SNTA1,ITGA8,HLA-DQB1,MIEN1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,H2AFZ,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,NAP1L4,CD209,RRP1B,SYNGR2,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,NIPSNAP3A,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,ANKMY2,FAM45A,RPL12,ATP10A,SLC39A3,GALNT13,TARS,ATP6V1A,TPSAB1/TPSB2,PREX1,TMEM189,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,RPS21,KIFAP3,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,RRM2B,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,SLCO2B1,MRPL24,DPT,PLD3,LHPP,ICT1,MTSS1,KLHL25,PAQR3,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,ZNF69,CD52,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,MRPL17,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,MT-TL1,APOE,NME1,AASDHPPT,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,SDHAF1,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,BZW2,TRAF3,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,RNASE1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,RPS13,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,UBA6,ARSA,MT-ND4L,GYS2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,RPLP1,SLC1A4,MECR,DENND4B,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,SPCS1,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,SERINC2,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,MT-ND3,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,PSMB10,PAM16,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,TAX1BP3,CA3,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,LAMP1,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,ADCK2,PEA15,PRMT5,P2RY12,CYCS,SCAMP3,RUFY3,MAPRE3,MVD,GAB2,RPS23,CLTB,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,LMO4,GPS2,ANLN,PSMC4,UQCR11,MARS,RPL28,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,SLC30A2,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,SURF1,IRF5,CTSB,C15orf39,NHLH1,PLTP,FTH1,EPHX1,CD163L1,EVA1B,GADD45B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,SLC25A1,ENG,MAGEC3,MYO5A,RPS16,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,UBE2I,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,FARS2,STAT1,MT-CO1,THBS4,PREB,MT-ATP6,TRIM55,IPO4,G6PD,TSN,KIF3B,APOLD1,APLP2,CPAMD8,THEMIS2,ARPC5,RAN,GHITM,DDX20,MKI67,GSS,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,C19orf53,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,DHRSX,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,MYL12A,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,PSME1,HIST1H1E,SLC48A1,CCDC85B,GLIS2,BRINP2,RHBDD2,TREM2,USP22,APOL4,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,C1QBP,RET,MDH2,BCKDK,C7orf50,MRPS15,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PACSIN3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,RAC1,CPVL,GPAA1,RASD1,C9orf16,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,TBCB,RRAGD,OAZ1,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,KIAA1683,ACSM2B,PLBD2,TMEM2,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,BRF2,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,PRELP,UCK1,MARCH4,TULP3,LYPLA1,TMEM33,RPL41,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,CD74,ZNF827,SLC35B2,GLIPR1,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,LURAP1L,TTC23,FAM96B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,WDR36,TMC2,SRA1,MT-TY,TRIB3,HSPA2,SPTLC3,GRN,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,SEMA3C,TSC22D2,TTYH3,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,KRTAP4-6,RHOG,ZNRF3,EIF3D,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,C17orf53,CBR1,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,SLC25A39,CDH20,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,RPSA,DOK5,ATP6V0C,UBXN1,SYCE1,SF3B5,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,SHB,CIDEA,KIFC3,KIF5B,TTL,EIF3I,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,TOR1A,TXNL4A,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,PTPA,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,PIP,FANCE,UCHL1,RPL35,SEC61A1,ACSM5,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,SLC7A6,NDUFS4,MBOAT7,LETM1,ADRM1,TYROBP,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,FCER1G,MS4A2,NR5A2,DVL3,CBX4,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,RAB9A,UTP4,MMRN1,TAF10,SDC4,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,ERV3-1,TNFRSF12A,SEPHS2,HMOX1,RNF167,PARK7,PCK2,KCNMA1,NDUFC2,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,COX17,CD160,VANGL1,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,RTN3	1320	
Molecular Transport	quantity	quantity of metal	1.54E-08	 	1.982	bias	-0.386	PLCB2,CRYAB,SLC31A1,ARF1,ATP2B1,PIK3R1,FCER1A,HRAS,CXCL9,HSPA5,PANX1,SLC9A1,GNB1,PTPRC,CXCL10,CD28,CAMK2D,PLCE1,CPM,MCOLN3,PIK3CG,CYBB,C1QBP,TP53,EIF2AK1,SPP1,LAIR1,STK39,PPP1R1B,ANXA2,TPSAB1/TPSB2,ADCYAP1R1,MAPT,COMMD1,INSR,VDAC1,AKR1B1,C3AR1,STEAP3,LCP2,FTH1,BANK1,PTGFR,APOE,LEP,F2RL3,CD2,FGF2,HLA-A,HYOU1,PPIA,FKBP1A,SMPD1,FAS,HMOX1,LYZ,EDN1,PTPRJ,PPP1R9B,SAA1,SLC40A1,S100A8,STIM1,SCNN1B,ADORA1,FCGR3A/FCGR3B,PRNP,CCR1,S100A1,SIGMAR1,VCAM1,SLC9A3R1,FCGR2A,IGKC,AP3D1,SLC12A2,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,CISD1,FTL,APLP2,FCER1G,MS4A2,BMPER,P2RX7,ADRA1A,NCAM1	92	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by leukocytes	1.60E-08	 	0.624	 	-0.161	SOCS3,PLCB2,CRYAB,TGFBR1,AGER,CMA1,PIK3R1,UNC5B,CTSG,HRAS,CXCL9,CXCL10,CD28,RSPO3,PIK3CG,CYBB,ZBTB16,TP53,PTX3,MIF,SPP1,NINJ1,EFS,PREX1,IL1RN,CTSB,CD14,SFRP1,PLTP,CYR61,ESR2,C3AR1,HSPB1,APOE,ADAM17,LEP,MSR1,CD2,HLA-A,HYOU1,ADIPOQ,PPIA,HIF1A,IL17RA,FAS,HMOX1,CES1,GBA,EDN1,TIMP1,THBS1,ANXA1,DUSP10,SAA1,S100A8,STIM1,CFH,STAT1,MAPKAPK2,NFE2L2,KRT10,GJB2,CCR1,VCAM1,UCP2,NQO1,TRPA1,ALOX5AP,CSF1R,APP,CXCL16,ITGB2,GLIS2,FCER1G,NR4A1,C6,P2RX7	77	
Cardiovascular Disease	infarction	Infarction	1.67E-08	 	-0.607	 	-0.110	APOB,AGER,SESN2,SH3GLB1,C1QA,PANX1,NNMT,ITGAV,CYBB,TUBA1C,SIAH2,GCLM,TXN,UNG,ATP5J,PTX3,MIF,PSMA6,TUBB2A,RAC1,IL1RN,SH2B3,MAPT,CD14,HTRA1,ESR2,HSPB1,APOE,LEP,HLA-A,UBQLN1,FGF2,DUSP6,GDF15,ADIPOQ,PPIA,HIF1A,TNFRSF12A,C1QTNF9,HMOX1,EDN1,TIMP1,ANXA1,ANXA5,STIM1,STAT1,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,PRNP,UCP2,FCGR2A,TUBB4B,HSPH1,EGR1,TUBG1,F13A1,SOD1,CSF1R,APP,GRN,ITGB2,CAPNS1,LGALS2,TREM2,FCER1G,P2RY12,C6,P2RX7,ADRA1A	71	
Cellular Assembly and Organization	development	development of cytoplasm	1.68E-08	Increased	2.780	bias	0.459	PFN1,ARF1,PIK3R1,MAP1B,FCER1A,HRAS,SDC4,TUBB,SLC9A1,CLIP1,GNB1,CTSD,DYNLL1,ATG9A,GLB1,PACS2,CHCHD2,CNTNAP1,AIF1,TESK1,MIF,CFL1,MTSS1,GNG2,CARMIL1,RAC1,STOML2,TPM3,MALSU1,MLST8,HAX1,LMCD1,HSPA8,MYL9,PREX1,SSBP1,ERP29,NR1D1,EMC6,MAPT,C3AR1,SIRPA,ARL2,APOE,PEX3,LEP,SLC4A2,STMN2,FGF2,DMD,CD74,PHLDB2,PARK7,EDN1,SORBS1,THBS1,FLNA,PEX10,ANXA1,LAMP1,TUB,DAB2,ARHGEF2,GNG5,ASAP3,ADORA1,AMOT,VCAM1,CAPZB,LETM1,IPO4,FCGR2A,GNA12,SLIRP,POLDIP2,FGF1,APP,FIS1,MCF2L,LAMP2,COL5A3,SUPV3L1,KCTD13,MYOC,CXXC5,FKBP4,NCKAP1L,DCX	88	
Molecular Transport	export	export of molecule	1.72E-08	Increased	2.896	bias	0.356	PLCB2,APOB,AGER,AHCYL1,RAN,NME2,XPO5,HRAS,CXCL10,CTSS,ABCC1,SLC7A5,CLCN3,TP53,HSPA9,RAC1,SLC38A3,NPR3,MAPT,CD14,ATOX1,EIF5A,PLTP,XPO6,FTH1,APOE,SCD,LEP,MSR1,FGF2,SLC1A5,GDF15,ADIPOQ,CRAT,XPOT,SMPD1,FAS,IRAK1,HMOX1,CES1,EDN1,FYTTD1,SAA1,SLC40A1,S100A8,CHCHD4,BCAP31,SCNN1B,HCAR2,LETM1,SLC12A2,SNTB1,SLC25A1,APP,GIPR,APOC1,NR5A2,ABCC3,P2RX7,NPC2	60	
Cardiovascular Disease	peripheral arterial disease	advanced stage peripheral arterial disease	1.90E-08	 	 	 	 	APOE,LAPTM5,MSR1,ADAP2,CECR1,HSPA4,THBS1,CTSS,TGFB2,SNX10,PLEKHO2,IFI30,DAB2,CFH,GULP1,CCR1,CD53,LCP1,UCP2,SPP1,LAIR1,HSPH1,VSIG4,CAPG,FYB,PLXND1,ARHGDIB,LMCD1,NGRN,NPR3,EVI2B,CTSB,TPP1,C3AR1,MAP4K4,FTH1	36	
Neurological Disease	degeneration	degeneration of nervous system	1.91E-08	Decreased	-3.043	bias	-0.254	VAC14,SLC9A1,CERS2,CTSD,GLB1,CYBB,NMNAT2,MTMR2,RET,CLCN3,UNG,TP53,STXBP1,PTPRQ,ASNA1,FGFR2,ARSA,IL1RN,MAPT,CTSB,NAGLU,CLCN7,SQSTM1,ESR2,APOE,UBQLN1,FGF2,ADIPOQ,SLC1A3,SMPD1,HIF1A,MAFG,UCHL1,JUN,GBA,PARK7,KCNMA1,TGFB2,TUB,STAT1,ADORA1,NFE2L2,NDUFS4,PRNP,TYROBP,SOD1,CISD2,CSF1R,KCNQ4,NFE2L1,APP,GRN,NR4A2,NTRK3,PPT1,PSAP,SLC1A2,TPP1,C6,NCAM1	60	
Metabolic Disease	amyloidosis	amyloidosis	1.93E-08	 	-0.743	bias	-0.099	AGER,PIK3R1,RAN,NCSTN,MT-CO2,ADGRL1,CXCL10,LGMN,CTSS,ATF4,TXN,UNG,TP53,SNRPA,PLD3,PPTC7,LARP4,HMGA1,CD68,PSMB2,MS4A4A,STIP1,CTSB,GAPDH,PLTP,ESR2,APOE,MS4A6A,DDIT3,UBQLN1,FGF2,SLC1A3,CD74,S100A7,UCHL1,LYZ,JUN,MT-CO3,NFE2L2,FCGR3A/FCGR3B,ALDH5A1,FCGR2A,TYROBP,IGKC,PLA2G2A,APP,FIS1,MT-ND1,NTRK3,SREBF2,MAZ,PSAP,TSPO,DCX,ADRA1A,PRKACB,GAB2,TUBB,HSPA5,BIN1,CTSD,PACS2,RET,GM2A,HSPA9,HNRNPAB,SYP,EPRS,PREX1,ADAM12,MAPT,SLC7A2,MAPK10,CD14,NAGLU,INSR,HTRA1,DOK5,SCD,LEP,SMPD1,HIF1A,MT-TN,ALDH2,HMOX1,BCYRN1,TIMP1,SAA1,SENP3,IGSF8,PRNP,MT-CO1,NQO1,MAPK9,SOD1,SERPINE2,CXCL16,TMEM2,APLP2,PSMD2,APOC1,SLC1A2,RTN3	103	
Cell Death and Survival	cell death	cell death of connective tissue cells	1.94E-08	 	0.067	 	-0.421	TGFBR1,AGER,ITSN1,PIK3R1,SH3GLB1,HRAS,SLC9A1,GLO1,SGPL1,EIF3B,PIK3CG,ABCC1,ATF4,TXN,UNG,TP53,SFT2D2,SFRP4,RHEB,TNFRSF10B,BCL2L14,FGFR2,IRF5,MNT,MBD4,RTN4,CTSB,DUSP4,SFRP1,CYR61,GSTP1,EPHX1,FTH1,GADD45B,DDIT3,FGF2,ADIPOQ,CA3,JUN,TOP2A,UBE2K,NFE2L2,TMEM123,EGR1,LZTS2,ENG,APP,GRN,MCF2L,LAMP2,NR4A2,USP22,FKBP4,NR4A1,TPP1,CYCS,RPL37,TRAF3,UNC5B,SDC4,HSPA5,CTBP1,CTSD,RHOG,ENTPD5,NUPR1,ITGAV,DPM3,NSMAF,EIF2AK1,PRKRA,SPP1,GNG2,RAC1,ADAM12,MAPT,GNL3,INSR,LEP,CD2,NELFB,ATF5,SMPD1,HIF1A,FAS,HMOX1,HINT1,PARK7,FLNA,TIMP1,SAA1,VCP,TGFB2,OAZ1,S100A8,STAT1,PRNP,EMD,MAPK9,SOD1,CSF1R,NFE2L1,ENO1,CIDEA,CAPNS1,EIF3I,UBA1,PPP2R1B	108	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities	familial motor neuron disease	familial motor neuron disease	1.94E-08	 	 	 	 	SIGMAR1,MT-ND6,CHCHD10,C9orf72,RRM2B,GARS,HSPB8,SOD1,C1QB,GRN,UCHL1,MT-ND5,NR4A2,PARK7,MAPT,VCP,SLC1A2,CHCHD2,SQSTM1,UBA1,ATP13A2,HSPB1	22	
Organismal Injury and Abnormalities, Tissue Morphology	size	size of lesion	1.98E-08	 	-0.781	 	-0.607	SOCS3,CRYAB,APOB,TGFBR1,AGER,SESN2,CD4,SH3GLB1,C1QA,PANX1,CTSS,PIK3CG,SIAH2,TXN,UNG,TP53,PTX3,MIF,SPP1,IL1RN,ESR2,APOE,LEP,MSR1,UBQLN1,HLA-A,FGF2,DUSP6,GDF15,ADIPOQ,PPIA,HIF1A,TNFRSF12A,C1QTNF9,HMOX1,CES1,TIMP1,ANXA5,ANXA1,SLC19A1,STAT1,MAPKAPK2,NFE2L2,PRNP,VCAM1,UCP2,EGR1,HSPH1,SOD1,APP,GRN,NR4A1,FCER1G,P2RX7	54	
Cellular Function and Maintenance	engulfment	engulfment of phagocytes	2.50E-08	Increased	4.018	bias	1.682	GAB2,AGER,MSR1,HYOU1,SMPD1,BIN1,FAS,PTPRC,CXCL10,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,CD209,MIF,SRA1,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	37	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of leukocytes	2.72E-08	Increased	3.567	bias	0.810	AGER,MAF,CTSG,C1QA,HLA-DQB1,CXCL9,CXCL10,PTPRC,ZBTB7B,CTSS,PIK3CG,TP53,LAIR1,TNFRSF10B,ANXA2,IRF5,SPON2,SFRP1,C3AR1,LCP2,BANK1,APOE,RAB32,GJB6,LAPTM5,DDIT3,HLA-A,ADIPOQ,HLA-DQA1,HYOU1,HSPB8,LGALS9,PPIA,FKBP1A,CD74,S100A7,IGHG3,PTPRJ,HLA-DRA,TPO,ADORA1,NFE2L2,FCGR3A/FCGR3B,CD209,SIGLEC1,TYROBP,FCGR2A,PLA2G2A,APP,AIP,GRN,FOS,ITGB2,PSME1,TREM2,PPT1,FCER1G,TRAF3,CD4,MBP,TLR8,STARD7,CD63,CD28,HSPA4,ITGAV,CYBB,RET,TBC1D10C,MIF,IL2RG,SPP1,BMP2K,RAB10,KLF4,TPSAB1/TPSB2,OSTM1,PREX1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,SIRPA,LEP,TOLLIP,MSR1,CD2,CD83,SMPD1,HIF1A,FAS,IRAK1,TNFRSF12A,HLA-G,HMOX1,EDN1,THBS1,ANXA1,DUSP10,SAA1,KIT,S100A8,CFH,STAT1,RAB8B,PRNP,VCAM1,NPY1R,HSPH1,AP3D1,HPS1,MAPK9,SOD1,IL20RB,CSF1R,FGF1,PAG1,VAMP8,C6,P2RX7	121	
Cardiovascular Disease	occlusion	occlusion of artery	2.97E-08	 	0.915	 	0.033	SOCS3,PLIN1,SLC7A11,APOB,PFN1,AGER,ITGA8,MKI67,SDC4,SLC9A1,GSS,CXCL10,NNMT,RHOG,CTSS,GAA,COMT,PIK3CG,ITGAV,ARHGEF26,TUBA1C,GCLM,TP53,CERS6,PTX3,MIF,SPP1,SGCG,TUBB2A,KLF4,FOSB,NPR3,MAPT,FMN2,RTN4,CD14,INSR,PLTP,ESR2,SCD,APOE,LEP,MSR1,ERN1,GDF15,CCDC167,ADIPOQ,FKBP1A,HMOX1,CES1,JUN,EDN1,SORBS1,TIMP1,THBS1,PLIN2,SAA1,TGFB2,S100A8,SCNN1B,ADORA1,HCAR2,NFE2L2,ALDH5A1,CCR1,SIGMAR1,VCAM1,COL5A2,TUBB4B,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,MAPK9,SOD1,PLA2G2A,APP,FOS,CXCL16,ITGB2,MCF2L,MTHFD1L,LAMP2,SUPV3L1,APOC1,NR4A1,P2RY12,GBE1	90	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis	2.98E-08	Decreased	-3.131	bias	-1.201	APOE,GJB6,FGF2,ADIPOQ,SH3GLB1,SMPD1,CERS2,ABR,LAMP1,STAM,CLCN3,NFE2L2,ATP13A2,ALDH5A1,NDUFS4,PRNP,ACP2,PSMC4,SOD1,ARSA,CSF1R,HAX1,APP,GRN,OSTM1,TREM2,MAPT,PPT1,CTSB,PSAP,CLCN7,SQSTM1,ESR2	33	
Carbohydrate Metabolism	synthesis	synthesis of carbohydrate	3.05E-08	Increased	2.764	bias	0.272	SOCS3,GFPT1,PLCB2,PLIN1,TGFBR1,ARF1,PIK3R1,LHCGR,VAC14,HRAS,SH3GLB1,CHST15,GNB1,PTPRC,CXCL10,HS6ST1,PGD,GYS1,CCND3,PIK3CG,ITGAV,ATF4,CHST11,MTMR2,PGP,GOT1,GPC1,DPM3,PPP1CA,MIF,SPP1,XYLT1,GNG2,RAC1,RAB10,GPAA1,GYS2,SERINC2,NR1D1,ADCYAP1R1,IL1RN,PIP5K1C,MPDU1,GAPDH,PLEK,INSR,SFRP1,AKR1B1,PTGFR,SCD,APOE,LEP,FGF2,PDGFA,HLA-A,DUSP6,DPM2,HS2ST1,ADIPOQ,HEXA,FAS,EDN1,SORBS1,ANXA1,TGFB2,KIT,ADORA1,PI4KA,ADCY2,SLC9A3R1,FCGR2A,G6PD,DGAT2,AGPAT1,CSF1R,ITGB2,NR4A2,NTRK3,NR4A1,GBE1,ADRA1A	81	
Cell Death and Survival	cell viability	cell viability of neuroblastoma cell lines	3.06E-08	 	1.179	bias	-0.064	APOE,AGER,NPY1R,HSPB8,SOD1,APP,HMOX1,LYZ,SREBF2,DPP3,MAPT,VCP,CYBB,PSAP,SLC40A1,GPC1,SQSTM1,ATP13A2,PRNP,HSPB1	20	
Cell Morphology, Cellular Function and Maintenance	autophagy	autophagy	3.09E-08	Increased	2.060	 	0.896	ICMT,C9orf72,AGER,SESN2,CD4,PIK3R1,HRAS,SH3GLB1,HSPA5,CTSD,PLCE1,ATG9A,GAA,MCOLN3,NUPR1,CYBB,ATF4,ANXA7,STAM,LMX1A,KIF5C,TBC1D10C,TP53,RHEB,SPP1,ACP2,TNFRSF10B,ARSA,HSPA8,OSTM1,CTSA,NR1D1,MAPT,DUSP4,SQSTM1,PAFAH1B2,SCD,SDHB,LEP,DDIT3,DAPK2,ERN1,PKM,HSPB8,ADIPOQ,FKBP1A,SMPD1,HIF1A,FAS,HMOX1,GBA,LAMP1,NACC1,S100A8,STIM1,STAT1,NFE2L2,AMFR,ATP13A2,NLRC4,PRNP,DAP,UCP2,LETM1,TBC1D9,NQO1,RAB7A,QSOX1,ENG,TRIB3,SOD1,CISD2,NRBF2,POLDIP2,APP,FIS1,CISD1,LAMP2,CAPNS1,TBC1D7	80	
Cell-To-Cell Signaling and Interaction, Cellular Movement	recruitment	recruitment of blood cells	3.22E-08	 	1.524	bias	-1.063	GAB2,CRYAB,APOB,KDM6B,AGER,CD4,PIK3R1,CTSG,FCER1A,CXCL9,CXCL10,CD28,SGPL1,RHOG,PIK3CG,TXN,PTX3,MIF,SPP1,RAC1,FLOT1,IRF5,NINJ1,TPSAB1/TPSB2,SPON2,PREX1,IL1RN,PIP5K1C,RTN4,CD14,SFRP1,CYR61,C3AR1,APOE,ADAM17,LEP,PLGRKT,GDF15,ADIPOQ,HIF1A,CD74,IL17RA,HMOX1,LYZ,JUN,EDN1,THBS1,ANXA1,CCL28,S100A8,HCAR2,NFE2L2,FCGR3A/FCGR3B,CCR1,VCAM1,UCP2,FCGR2A,EGR1,ST3GAL6,ALOX5AP,F13A1,CSF1R,APP,FOS,CXCL16,ITGB2	66	
Cellular Movement	cell movement	cell movement of tumor cell lines	3.46E-08	Increased	5.082	bias	1.620	TGFBR1,WHSC1,AGER,PIK3R1,CTSG,HRAS,CXCL9,GNB1,CXCL10,DGCR6L,SRPX2,PIK3CG,KEAP1,ST6GALNAC2,AFAP1,TP53,SFRP4,LCP1,TPM3,FGFR2,ANXA2,HMGA1,HAX1,NINJ1,ARHGDIB,CTSB,ALCAM,ARHGAP35,SQSTM1,CYR61,ESR2,RAP2A,NME1,ADAM17,ARPC1B,OSGIN1,FGF2,FAM89B,GDF15,ADIPOQ,PPIA,SDC3,ASNS,ENAH,SYNM,S100A7,JUN,DAB2,STIM1,ASPH,NFE2L2,CALML3,S100A1,PLXNA1,PTPRK,EGR1,GNA12,ENG,IPO7,SNCG,APP,GRN,FOS,MCF2L,NR4A2,NTRK3,FLNC,PRMT5,WBP2,SOX9,NCAM1,GAB2,SOCS3,SEPT9,ARF1,USP5,SDC4,MTCH2,CTBP1,CD28,RHOG,CXCL14,ITGAV,KPNA2,TUBA1C,C1QBP,RET,CLCN3,SHOC2,MIF,SPP1,GSDMB,PCSK6,PHB2,RAC1,KLF4,PKN1,LMCD1,FOSB,PREX1,SDCBP,ADAM12,ACKR3,CAPN2,CST6,HTRA1,SIRPA,UBE2I,ETV5,CD151,PEBP1,IGFBP4,LEP,F2RL3,PDGFA,PLGRKT,PKM,HIF1A,HNRNPK,HDGF,CLCN4,HMOX1,EDN1,TIMP1,THBS1,FLNA,ANXA1,VCP,TGFB2,KIT,IGSF8,S100A8,STAT1,MAPKAPK2,PRNP,NDUFAF3,VCAM1,SLC9A3R1,BHLHE41,SLC12A2,MAPK9,SNX27,GIT1,CSF1R,FGF1,CAPNS1,MAP4K4	147	
Cardiovascular Disease	arteriosclerosis	arteriosclerosis	3.64E-08	 	0.757	 	-0.001	SOCS3,PLIN1,SLC7A11,APOB,PFN1,AGER,ITGA8,MKI67,SDC4,SLC9A1,GSS,CXCL10,NNMT,CTSS,GAA,COMT,PIK3CG,ITGAV,ARHGEF26,TUBA1C,GCLM,TP53,CERS6,PTX3,MIF,SPP1,SGCG,TUBB2A,KLF4,FOSB,NPR3,FMN2,RTN4,CD14,INSR,PLTP,ESR2,SCD,APOE,LEP,MSR1,ERN1,GDF15,CCDC167,ADIPOQ,FKBP1A,HMOX1,CES1,JUN,EDN1,SORBS1,TIMP1,THBS1,PLIN2,SAA1,S100A8,SCNN1B,ADORA1,MAPKAPK2,HCAR2,NFE2L2,ALDH5A1,CCR1,SIGMAR1,VCAM1,COL5A2,TUBB4B,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,MAPK9,SOD1,PLA2G2A,APP,FOS,CXCL16,ITGB2,MCF2L,MTHFD1L,LAMP2,SUPV3L1,APOC1,NR4A1,P2RY12,GBE1	88	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of central nervous system	3.70E-08	Decreased	-2.164	 	-1.784	APOE,GJB6,FGF2,ADIPOQ,PSMC4,SH3GLB1,SOD1,CERS2,APP,GRN,PPT1,MAPT,LAMP1,CLCN7,SQSTM1,NFE2L2,ATP13A2,NDUFS4,PRNP	19	
Cardiovascular Disease	atherosclerosis	atherosclerosis	3.73E-08	 	0.916	 	0.064	SOCS3,PLIN1,SLC7A11,APOB,PFN1,AGER,ITGA8,MKI67,SDC4,SLC9A1,GSS,CXCL10,NNMT,CTSS,GAA,COMT,PIK3CG,ITGAV,ARHGEF26,TUBA1C,GCLM,TP53,CERS6,PTX3,MIF,SPP1,SGCG,TUBB2A,KLF4,FOSB,NPR3,FMN2,RTN4,CD14,INSR,PLTP,ESR2,SCD,APOE,LEP,MSR1,ERN1,GDF15,CCDC167,ADIPOQ,FKBP1A,HMOX1,CES1,JUN,EDN1,SORBS1,TIMP1,THBS1,PLIN2,SAA1,S100A8,SCNN1B,ADORA1,HCAR2,NFE2L2,ALDH5A1,CCR1,SIGMAR1,VCAM1,COL5A2,TUBB4B,EGR1,TUBG1,RNF157,DGAT2,ALOX5AP,F13A1,MAPK9,SOD1,PLA2G2A,APP,FOS,CXCL16,ITGB2,MCF2L,MTHFD1L,LAMP2,SUPV3L1,APOC1,NR4A1,P2RY12,GBE1	87	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of leukocytes	3.80E-08	 	1.425	bias	-1.127	GAB2,CRYAB,APOB,KDM6B,AGER,CD4,PIK3R1,CTSG,FCER1A,CXCL9,CXCL10,CD28,SGPL1,PIK3CG,TXN,PTX3,MIF,SPP1,RAC1,FLOT1,IRF5,NINJ1,TPSAB1/TPSB2,SPON2,PREX1,IL1RN,PIP5K1C,RTN4,CD14,SFRP1,CYR61,C3AR1,APOE,ADAM17,LEP,PLGRKT,GDF15,ADIPOQ,HIF1A,CD74,IL17RA,HMOX1,LYZ,JUN,EDN1,THBS1,ANXA1,CCL28,S100A8,HCAR2,NFE2L2,FCGR3A/FCGR3B,CCR1,VCAM1,UCP2,FCGR2A,EGR1,ST3GAL6,F13A1,ALOX5AP,CSF1R,APP,FOS,CXCL16,ITGB2	65	
Cell Morphology, Cellular Function and Maintenance	transmembrane potential	transmembrane potential of mitochondria	4.14E-08	 	-0.339	 	-0.111	CRYAB,LEP,ITSN1,DDIT3,CD2,FGF2,CD4,BARD1,BCO2,SMPD1,HIF1A,FAS,CD28,HMOX1,HSPA4,SLC25A6,PARK7,VCP,STOX1,BCAP31,ZBTB16,EYA2,NDUFAB1,NFE2L2,LONP1,TP53,CD160,UCP2,PPP1R1B,GNA12,TNFRSF10B,RAC1,PHB2,STOML2,MAPK9,SOD1,CISD2,APP,CISD1,LGALS2,MAPT,PRELID1,RTN4,CYCS,VDAC1,ESR2,HSPB1	47	
Cardiovascular System Development and Function, Organismal Development	vasculogenesis	vasculogenesis	4.51E-08	 	1.691	bias	-0.760	CRYAB,TGFBR1,APOB,AGER,HRAS,COL8A1,C1QA,HLA-DQB1,ODC1,SPRY4,CXCL10,POR,SGPL1,SRPX2,PIK3CG,ARHGEF26,MGAT1,TP53,YWHAG,PAQR3,FGFR2,ANXA2,ANGPTL1,YARS,CTSB,ALCAM,CYR61,ITGA7,C3AR1,APOE,PIM3,DDIT3,GBP1,SNX17,FGF2,ADIPOQ,PPIA,COL15A1,OGT,JUN,PTPRJ,DAB2,STIM1,SARS,AMOT,PLOD3,EGR1,MESP1,ENG,APP,GRN,ITGB2,MCF2L,KIF7,NR4A1,PSAP,ARHGDIA,BMPER,SEMA3C,HOXB5,SOCS3,SEPT9,UNC5B,TYMP,SDC4,CD63,CD28,HS6ST1,RHOG,CXCL14,ITGAV,CYBB,STAB1,GCLM,GPC1,PTX3,PFKFB3,SPP1,STK39,RAC1,CITED1,PDCL3,COMMD1,INSR,MEGF8,AKR1B1,HTRA1,CD151,IGFBP4,SPRED1,LEP,PDGFA,ERN1,PKM,SMPD1,HIF1A,PDGFC,RAMP2,FAS,TNFRSF12A,HMOX1,EDN1,TIMP1,THBS1,FLNA,KCNMA1,SAA1,TGFB2,KIT,CYGB,S100A8,SOX18,STAT1,MAPKAPK2,THBS4,VCAM1,G6PD,SOD1,CISD2,PLXND1,CSF1R,EDF1,FGF1,SHB,WARS,CAPNS1,CXXC5,EPHB3,C6	129	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of antigen presenting cells	4.83E-08	 	0.955	bias	-0.991	TRAF3,AGER,CD4,MAF,HLA-DQB1,STARD7,CXCL10,CTSS,ITGAV,CYBB,TP53,MIF,TNFRSF10B,RAB10,ANXA2,KLF4,SPON2,OSTM1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,SIRPA,APOE,RAB32,GJB6,LEP,TOLLIP,MSR1,DDIT3,HLA-A,HLA-DQA1,ADIPOQ,HSPB8,LGALS9,CD74,FAS,IRAK1,TNFRSF12A,HMOX1,EDN1,THBS1,DUSP10,TPO,STAT1,ADORA1,RAB8B,PRNP,CD209,TYROBP,FCGR2A,AP3D1,SOD1,CSF1R,PLA2G2A,APP,PSME1,TREM2,PPT1,FCER1G,C6,P2RX7	63	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Leigh syndrome with complex I deficiency	Leigh syndrome with complex I deficiency	4.87E-08	 	 	 	 	MT-ND6,MT-ND5,NDUFA9,NDUFS8,NDUFA12,MT-ND3,NDUFS3,MT-ND2,NDUFA2,NDUFS4	10	
Cancer, Organismal Injury and Abnormalities	advanced malignant tumor	advanced malignant tumor	5.22E-08	Increased	2.313	 	1.238	TGFBR1,AGER,PIK3R1,RRM2B,HRAS,CXCL9,POR,PTPRC,DGCR6L,PIK3CG,TMSB10/TMSB4X,TP53,TNFRSF10B,TUBB2A,FGFR2,HMGA1,CD52,HAX1,ANGPTL1,CCND2,CTSB,ALCAM,GLUL,DUSP4,SFRP1,SQSTM1,CYR61,ESR2,GSTP1,STEAP3,S100A11,APOE,NME1,ADAM17,MSC,TCEA1,SRD5A1,FGF2,DUSP6,GDF15,HYOU1,LGALS9,PPIA,FKBP1A,CD74,COL15A1,ENAH,ANXA5,TOP2A,DAB2,STIM1,HCAR2,FCGR3A/FCGR3B,MYL12A,FCGR2A,TUBB4B,EPB41L4B,GNA12,ENG,SNCG,FOS,FTL,USP22,PSAP,P2RY12,SEMA3C,ABCC3,NCAM1,SOCS3,SLC7A11,AKR1C3,CSNK1A1,TLR8,LHCGR,NRN1,RNASE1,TUBB,CD28,CYP3A5,HOXA10,ITGAV,IFI30,CYBB,STAB1,ANXA7,TUBA1C,C1QBP,RET,CLCN3,CBR1,PTX3,MIF,IL2RG,SPP1,HNRNPAB,CAPG,KLF4,DYNLRB1,LMCD1,PIK3R3,EFS,SDCBP,ADAM12,ACKR3,IL1RN,CAPN2,INSR,HTRA1,TMEM176B,CD151,ERAP2,IGFBP4,SCD,STMN2,EPB41L3,PDGFA,DMD,HIF1A,IL17RA,PLPP1,FAS,TNFRSF12A,HMOX1,EDN1,TIMP1,THBS1,FLNA,KCNMA1,ANXA1,TGFB2,LOC102724428/SIK1,KIT,RNH1,CFH,STAT1,ALPL,PRNP,NACA,VCAM1,NDUFB4,AKR1C1/AKR1C2,BHLHE41,TUBG1,SLC5A3,GIT1,CSF1R,NDUFA13,ATIC,FGF1,CLGN,LGALS2,CXXC5	152	
Lipid Metabolism, Small Molecule Biochemistry	storage	storage of lipid	5.56E-08	 	-0.168	 	-0.594	SCD,APOE,PLIN1,APOB,LEP,MSR1,EGR1,GM2A,SURF1,DGAT2,ADIPOQ,HEXA,SMPD1,ARSA,OSTM1,CISD1,CIDEA,SREBF2,PLIN2,PLIN5,OSBPL11,ITGAV,ACVR1C	23	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of myeloid cells	5.69E-08	Increased	4.649	bias	 	PFN1,AGER,CD4,CTSG,CXCL9,CXCL10,PTPRC,CD28,PIK3CG,CXCL14,CYBB,C1QBP,AIF1,TMSB10/TMSB4X,MIF,SPP1,RAC1,FLOT1,CAPG,TPSAB1/TPSB2,NINJ1,PREX1,YARS,PIP5K1C,C3AR1,CD151,APOE,LITAF,DAPK2,LGALS9,PPIA,CD74,S100A7,EDN1,PTPRJ,THBS1,SAA1,CCL28,ANXA1,TGFB2,S100A8,STIM1,ADORA1,MAPKAPK2,HCAR2,PRNP,CCR1,RPS19,THBS4,FCGR2A,MAPK9,GIT1,CSF1R,APP,GRN,ITGB2,MT-ND1,FCER1G,NCKAP1L	59	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cell movement	cell movement of macrophages	6.42E-08	 	1.778	bias	-0.132	PFN1,AGER,CTSG,HRAS,CXCL9,CXCL10,PIK3CG,CYBB,STAB1,TP53,PTX3,MIF,SPP1,RAC1,NINJ1,IL1RN,SH2B3,PLTP,CYR61,C3AR1,APOE,ADAM17,LITAF,LEP,ADIPOQ,CD74,HIF1A,IL17RA,HMOX1,CES1,GBA,PTPRJ,EDN1,FLNA,THBS1,SAA1,DUSP10,ANXA1,MAPKAPK2,HCAR2,NFE2L2,NLRC4,PRNP,CCR1,TYROBP,NQO1,ENG,PLXND1,CSF1R,APP,ITGB2,GLIS2,TREM2,C6,P2RX7	55	
Cellular Function and Maintenance	engulfment	engulfment of blood cells	6.42E-08	Increased	4.282	bias	1.760	APOE,GAB2,AGER,MSR1,HYOU1,SMPD1,BIN1,FAS,PTPRC,CXCL10,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,GULP1,TP53,EIF2AK1,PTX3,SIGLEC1,CD209,MIF,SRA1,UCP2,FCGR2A,RAC1,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	40	
Cancer, Organismal Injury and Abnormalities	benign connective or soft tissue neoplasm	benign connective or soft tissue neoplasm	6.99E-08	 	 	 	 	SOCS3,AHCYL1,AGER,RPE,MEGF9,MAF,LHCGR,HRAS,COL8A1,RAB9A,MT-CO2,POR,CXCL14,RPL19,RET,WNT5B,TP53,SLC2A5,CAPN6,PSMA6,DPT,PLD3,SLC24A3,FGFR2,AP2S1,PIK3R3,KCNG1,CCND2,ADAM12,ALDOA,SFRP1,INSR,CYR61,ESR2,RORB,FTH1,S100A11,PHLDA2,FGF2,FKBP1A,SLC7A1,PLPP1,RAMP2,COL15A1,FAS,COL16A1,JUN,VCP,TOP2A,KIT,CFH,PI4KA,RPS19,COL5A2,DLGAP4,EGR1,DVL1,SLC5A3,CSF1R,STXBP6,FOS,RPS15,COL5A3,NR4A2,PCCA,NR4A1,NR5A2,DCX,ATP6V1B2,ADRA1A	70	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of myeloid cells	7.39E-08	 	1.394	 	0.246	APOE,CRYAB,PFN1,AGER,DDIT3,FGF2,ADIPOQ,CTSG,IL17RA,FAS,CXCL10,CD28,HMOX1,EDN1,TIMP1,THBS1,ANXA1,PIK3CG,KIT,S100A8,RET,FCGR3A/FCGR3B,NLRC4,CCR1,PTX3,MIF,VCAM1,SPP1,FCGR2A,EGR1,FGFR2,SOD1,IRF5,FGF1,GRN,ITGB2,ACKR3,IL1RN,NR4A1,C6	40	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of blood cells	7.46E-08	 	1.898	 	-0.410	TGFBR1,APOB,AGER,PIK3R1,MAF,HRAS,C1QA,HLA-DQB1,SLC35C1,EEF1D,CHST2,PTPRC,CXCL10,ZBTB7B,SGPL1,LGMN,CCND3,CTSS,PIK3CG,ST6GALNAC2,MGAT4B,SPTB,ATF4,STAM,APEX2,ZBTB16,TP53,RBM38,LAIR1,FGFR2,TSPAN33,ARHGDIB,HAX1,SPON2,MNT,CCND2,NPR3,IL10RA,B3GNT5,C3AR1,ESR2,STEAP3,LCP2,GSTP1,BANK1,APOE,PIM3,ADAM17,GADD45B,DDIT3,PSMB10,HLA-A,GDF15,HLA-DQA1,ADIPOQ,PPIA,CD74,CES1,JUN,GBA,PTPRJ,SORBS1,CCL28,SLC19A1,NFE2L2,CCR1,RPS19,SIGLEC1,TYROBP,FCGR2A,IGKC,EGR1,GNA12,ISG15,APP,FOS,PI3,ITGB2,TREM2,FCER1G,NR4A1,PSAP,ARHGDIA,GAB2,SOCS3,TRAF3,CD4,MBP,LHCGR,FCER1A,STARD7,CD28,CTSD,PLCE1,COMT,CXCL14,CYBB,STAB1,EIF2AK1,MIF,IL2RG,SPP1,HSPA9,RAC1,DMTN,FYB,KLF4,PKN1,FOSB,PREX1,ADAM12,ACKR3,IL1RN,SH2B3,MAPT,PIK3AP1,CYP4A11,SIRPA,SPRED1,LITAF,LEP,SLC7A1,SMPD1,DMD,CD83,HIF1A,IL17RA,PDGFC,FAS,IRAK1,CIAPIN1,HLA-G,HMOX1,ALDH2,HINT1,PARK7,TIMP1,THBS1,FLNA,DUSP10,SAA1,KIT,S100A8,CFH,STAT1,MAPKAPK2,ALPL,PRNP,VCAM1,NPY1R,NQO1,ST3GAL6,VSIG4,MAPK9,F13A1,SOD1,KIFAP3,CSF1R,IL20RB,NFE2L1,CXCL16,CAPNS1,LGALS2,SLC14A1,PAG1,C6,P2RX7,CARM1	168	
Cell-To-Cell Signaling and Interaction, Cellular Movement	recruitment	recruitment of cells	8.31E-08	 	1.795	bias	-0.893	GAB2,CRYAB,APOB,KDM6B,AGER,CD4,PIK3R1,CTSG,FCER1A,CXCL9,CD63,CXCL10,CD28,SGPL1,RHOG,PIK3CG,TXN,PTX3,MIF,SPP1,RAC1,FLOT1,IRF5,NINJ1,TPSAB1/TPSB2,SPON2,PREX1,IL1RN,PIP5K1C,RTN4,CD14,SFRP1,CYR61,C3AR1,APOE,ADAM17,LEP,FGF2,PLGRKT,GDF15,ADIPOQ,HIF1A,CD74,IL17RA,HMOX1,LYZ,JUN,EDN1,THBS1,ANXA1,CCL28,S100A8,HCAR2,NFE2L2,FCGR3A/FCGR3B,CCR1,VCAM1,UCP2,FCGR2A,EGR1,ST3GAL6,ALOX5AP,F13A1,ENG,CSF1R,APP,FOS,CXCL16,ITGB2	69	
Cellular Function and Maintenance	engulfment	engulfment of leukocytes	9.06E-08	Increased	4.276	bias	1.738	GAB2,APOE,AGER,MSR1,HYOU1,SMPD1,BIN1,FAS,PTPRC,CXCL10,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,CD209,MIF,SRA1,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	38	
Cell Death and Survival, DNA Replication, Recombination, and Repair	fragmentation	fragmentation of DNA	9.06E-08	 	0.788	 	0.597	APOE,CRYAB,LEP,DDIT3,MSR1,CD2,UBQLN1,DNASE1L3,PAM16,PIK3R1,BARD1,CTSG,ADIPOQ,PPIA,HRAS,FAS,CD28,JUN,KEAP1,TOP2A,TGFB2,NACC1,STAT1,PRNP,TP53,CD53,RAC1,MAPK9,SOD1,TPSAB1/TPSB2,APP,GRN,ENO1,MAPT,PPT1,RTN4,CAPN2,HSPB1	38	
Cancer, Organismal Injury and Abnormalities	metastasis	metastasis	9.24E-08	Increased	2.313	 	1.256	TGFBR1,AGER,PIK3R1,HRAS,CXCL9,POR,PTPRC,DGCR6L,PIK3CG,TMSB10/TMSB4X,TP53,TNFRSF10B,TUBB2A,FGFR2,HMGA1,HAX1,ANGPTL1,CCND2,CTSB,GLUL,ALCAM,DUSP4,SFRP1,SQSTM1,CYR61,ESR2,GSTP1,STEAP3,S100A11,APOE,NME1,ADAM17,MSC,TCEA1,SRD5A1,FGF2,DUSP6,GDF15,HYOU1,LGALS9,PPIA,FKBP1A,ENAH,ANXA5,TOP2A,STIM1,HCAR2,FCGR3A/FCGR3B,MYL12A,FCGR2A,TUBB4B,EPB41L4B,GNA12,ENG,SNCG,FOS,FTL,USP22,PSAP,P2RY12,ABCC3,NCAM1,SOCS3,SLC7A11,AKR1C3,CSNK1A1,TLR8,LHCGR,NRN1,RNASE1,TUBB,CD28,CYP3A5,HOXA10,ITGAV,IFI30,CYBB,STAB1,ANXA7,TUBA1C,C1QBP,RET,CLCN3,CBR1,PTX3,MIF,IL2RG,SPP1,HNRNPAB,CAPG,DYNLRB1,LMCD1,PIK3R3,EFS,SDCBP,ADAM12,ACKR3,IL1RN,CAPN2,INSR,HTRA1,CD151,ERAP2,SCD,STMN2,EPB41L3,PDGFA,DMD,HIF1A,IL17RA,FAS,TNFRSF12A,HMOX1,EDN1,TIMP1,FLNA,THBS1,ANXA1,TGFB2,LOC102724428/SIK1,KIT,RNH1,STAT1,ALPL,PRNP,NACA,VCAM1,NDUFB4,AKR1C1/AKR1C2,BHLHE41,TUBG1,SLC5A3,GIT1,CSF1R,NDUFA13,ATIC,FGF1,CLGN,LGALS2	139	
Cell-To-Cell Signaling and Interaction	activation	activation of cells	1.08E-07	Increased	4.597	bias	1.462	CRYAB,APOB,AGER,MAF,CTSG,C1QA,HLA-DQB1,CXCL9,PTPRC,CXCL10,ZBTB7B,CTSS,PIK3CG,SPTB,PLXNB2,TP53,CFL1,LAIR1,TNFRSF10B,ANXA2,IRF5,SPON2,IL10RA,SFRP1,SQSTM1,PLTP,CYR61,C3AR1,LCP2,BANK1,APOE,RAB32,GJB6,LAPTM5,SLC4A2,DDIT3,FGF2,HLA-A,HSPB8,HYOU1,HLA-DQA1,ADIPOQ,LGALS9,PPIA,FKBP1A,CD74,S100A7,IGHG3,PTPRJ,HLA-DRA,STIM1,TPO,ADORA1,NFE2L2,FCGR3A/FCGR3B,SIGLEC1,CD209,TYROBP,FCGR2A,PLA2G2A,AIP,APP,GRN,FOS,ITGB2,PSME1,TREM2,PPT1,FCER1G,NR4A1,PRMT5,P2RY12,BMPER,TRAF3,CD4,MBP,TLR8,FCER1A,STARD7,CD63,CD28,HSPA4,ITGAV,CYBB,RET,TBC1D10C,STXBP1,MIF,IL2RG,BMP2K,SPP1,RAB10,RAC1,BAMBI,KLF4,TPSAB1/TPSB2,OSTM1,PREX1,ADAM12,ACKR3,IL1RN,MAPT,SLC7A2,CD14,CLCN7,PLEK,INSR,SIRPA,LEP,TOLLIP,F2RL3,MSR1,CD2,PDGFA,ERN1,PKM,SMPD1,CD83,HIF1A,PDGFC,PLPP1,FAS,IRAK1,TNFRSF12A,HLA-G,HMOX1,EDN1,PPP1R9B,TIMP1,THBS1,KCNMA1,ANXA1,DUSP10,SAA1,TGFB2,KIT,S100A8,CFH,STAT1,RAB8B,PRNP,THBS4,VCAM1,NPY1R,HSPH1,AP3D1,HPS1,TRPA1,MAPK9,F13A1,SOD1,IL20RB,CSF1R,FGF1,SERPINE2,PAG1,VAMP8,C6,P2RX7	159	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders	familial dementia	familial dementia	1.10E-07	 	 	 	 	TP53,APOE,CHCHD10,C9orf72,SOD1,CSF1R,APP,GRN,CTSD,MT-ND1,PARK7,MAPT,VCP,APOC1,MAPK10,SQSTM1	16	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of myeloid cells	1.17E-07	 	1.748	bias	-0.425	TRAF3,AGER,CD4,MAF,TLR8,CXCL9,CD63,CXCL10,ITGAV,CYBB,RET,TP53,MIF,SPP1,ANXA2,KLF4,SPON2,OSTM1,PREX1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,SFRP1,SIRPA,LCP2,APOE,GJB6,LEP,TOLLIP,MSR1,DDIT3,HLA-A,ADIPOQ,PPIA,FKBP1A,IRAK1,TNFRSF12A,S100A7,HMOX1,EDN1,THBS1,ANXA1,DUSP10,SAA1,KIT,S100A8,CFH,STAT1,ADORA1,PRNP,VCAM1,TYROBP,FCGR2A,SOD1,CSF1R,PLA2G2A,APP,GRN,ITGB2,TREM2,PPT1,FCER1G,C6,P2RX7	66	
Cancer	transformation	transformation of fibroblast cell lines	1.27E-07	Increased	3.054	bias	0.688	PRKACB,ITSN1,CD4,PIK3R1,HRAS,DIRAS1,BIN1,EEF1D,ODC1,DYNLL1,RHOG,CCND3,PIK3CG,RET,TP53,RAC1,TPM3,FGFR2,HMGA1,IRF5,FOSB,BTG2,MAPK10,TMEM176B,RPL41,FTH1,RPS3A,PDGFA,FGF2,BARD1,JUN,ASPH,FCGR3A/FCGR3B,ADCY2,GNA12,EGR1,G6PD,MAPK9,LZTS2,KIFAP3,CSF1R,ATIC,NDUFA13,FGF1,MCF2L,FOS,NTRK3,SBF1,EIF3I,PRMT5,SOX9,DNPH1	52	
Metabolic Disease, Neurological Disease, Psychological Disorders	Alzheimer's disease	Alzheimer's disease	1.32E-07	 	 	 	 	PRKACB,GAB2,AGER,PIK3R1,RAN,NCSTN,MT-CO2,HSPA5,TUBB,BIN1,ADGRL1,CXCL10,CTSD,LGMN,CTSS,PACS2,ATF4,TXN,UNG,TP53,SNRPA,PLD3,GM2A,HSPA9,PPTC7,HNRNPAB,SYP,LARP4,HMGA1,EPRS,PREX1,CD68,ADAM12,MS4A4A,MAPT,STIP1,SLC7A2,CTSB,MAPK10,GAPDH,CD14,INSR,PLTP,HTRA1,ESR2,DOK5,SCD,APOE,LEP,DDIT3,MS4A6A,FGF2,UBQLN1,SLC1A3,SMPD1,HIF1A,CD74,MT-TN,S100A7,UCHL1,HMOX1,ALDH2,JUN,TIMP1,BCYRN1,SENP3,MT-CO3,IGSF8,NFE2L2,ALDH5A1,FCGR3A/FCGR3B,PRNP,MT-CO1,TYROBP,FCGR2A,IGKC,NQO1,MAPK9,SOD1,PLA2G2A,SERPINE2,APP,CXCL16,FIS1,APLP2,TMEM2,MT-ND1,NTRK3,SREBF2,APOC1,TSPO,SLC1A2,PSAP,DCX,RTN3,ADRA1A	96	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of leukocytes	1.45E-07	 	1.664	 	-0.654	TGFBR1,APOB,AGER,PIK3R1,MAF,HRAS,C1QA,HLA-DQB1,SLC35C1,EEF1D,CHST2,PTPRC,CXCL10,ZBTB7B,SGPL1,LGMN,CCND3,CTSS,PIK3CG,ST6GALNAC2,MGAT4B,STAM,ZBTB16,APEX2,TP53,LAIR1,FGFR2,TSPAN33,ARHGDIB,HAX1,SPON2,MNT,IL10RA,B3GNT5,C3AR1,ESR2,GSTP1,LCP2,BANK1,APOE,PIM3,ADAM17,GADD45B,DDIT3,PSMB10,HLA-A,GDF15,HLA-DQA1,ADIPOQ,PPIA,CD74,CES1,GBA,PTPRJ,SORBS1,CCL28,SLC19A1,NFE2L2,CCR1,SIGLEC1,TYROBP,FCGR2A,IGKC,EGR1,GNA12,APP,ISG15,FOS,PI3,ITGB2,TREM2,FCER1G,NR4A1,PSAP,ARHGDIA,GAB2,SOCS3,TRAF3,CD4,MBP,LHCGR,FCER1A,STARD7,CD28,CTSD,PLCE1,COMT,CXCL14,CYBB,STAB1,MIF,IL2RG,SPP1,RAC1,FYB,KLF4,PKN1,FOSB,PREX1,ADAM12,ACKR3,IL1RN,SH2B3,MAPT,PIK3AP1,CYP4A11,SIRPA,SPRED1,LITAF,LEP,SMPD1,DMD,CD83,HIF1A,IL17RA,PDGFC,FAS,IRAK1,HLA-G,HMOX1,ALDH2,HINT1,TIMP1,THBS1,FLNA,DUSP10,SAA1,KIT,S100A8,CFH,STAT1,MAPKAPK2,ALPL,PRNP,VCAM1,NPY1R,NQO1,ST3GAL6,VSIG4,MAPK9,F13A1,SOD1,KIFAP3,IL20RB,CSF1R,CXCL16,LGALS2,PAG1,C6,P2RX7,CARM1	151	
Cell-To-Cell Signaling and Interaction	adhesion	adhesion of blood cells	1.50E-07	Increased	3.488	bias	0.971	GAB2,PER1,AGER,CD4,CTSG,HRAS,C1QA,SLC35C1,CXCL9,PANX1,PTPRC,CXCL10,CD28,PIK3CG,ST6GALNAC2,CYBB,STAB1,ANXA7,TXN,TP53,PTX3,LCP1,MIF,SPP1,RAC1,FYB,NINJ1,SPON2,PREX1,PIP5K1C,ALCAM,CD14,PLTP,ITGA7,SIRPA,LCP2,CD151,RAP2A,APOE,ADAM17,MSR1,CD2,GDF15,ADIPOQ,LGALS9,DMD,CD83,HIF1A,CD74,FAS,THBS1,ANXA1,CCL28,ANXA5,SAA1,KIT,S100A8,STAT1,ADORA1,FCGR3A/FCGR3B,CCR1,CD209,VCAM1,FCGR2A,DNAJC1,APP,ITGB2,FCER1G,P2RY12,BMPER,P2RX7	71	
Inflammatory Response	immune response	immune response of cells	1.57E-07	Increased	6.123	bias	3.327	SOCS3,GAB2,TRAF3,PFN1,AGER,CD4,FCER1A,TLR8,CTSG,C1QA,HLA-DQB1,BIN1,CLIP1,SPRY4,PTPRC,CXCL10,CD28,CTSD,RHOG,ABR,CTSS,PIK3CG,ITGAV,RET,CLCN3,GULP1,EIF2AK1,PTX3,TP53,PRKRA,MIF,LAIR1,TNPO1,RAC1,CAPG,MLST8,CMC2,HSPA8,MNT,CD68,PIP5K1C,MAPT,CTSB,IL10RA,CD14,GAPDH,C3AR1,LCP2,SIRPA,HSPB1,APOE,LITAF,LEP,MSR1,SLC1A5,HLA-A,ERN1,ADIPOQ,LGALS9,CD83,SMPD1,CD74,FAS,IRAK1,HMOX1,IGHG3,PTPRJ,THBS1,ANXA5,SAA1,ANXA1,TOP2A,TUB,STIM1,S100A8,ADORA1,STAT1,MAPKAPK2,FCGR3A/FCGR3B,RAB8B,PRNP,PLXNA1,SIGLEC1,VCAM1,UCP2,TRIM55,TYROBP,FCGR2A,IGKC,GNA12,ENG,OTUB2,ISG15,APP,ITGB2,KIF2A,NR4A2,TREM2,FCER1G,IGHA1,P2RX7	101	
Post-Translational Modification	conformational modification	conformational modification of protein	1.64E-07	 	 	 	 	TP53,CRYAB,RAB7A,PPIA,SH3GLB1,QSOX1,FKBP1A,DNAJC1,TBCA,HSPA5,HSPA2,AIP,HSPA8,ERP29,PDIA6,PDCL3,ENTPD5,PIGK,FKBP4,AARS,TXN,CHCHD4,FKBP5,HSPB1	24	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of antigen presenting cells	1.66E-07	Increased	2.593	bias	0.263	PFN1,AGER,CTSG,HRAS,CXCL9,CXCL10,NARS,PIK3CG,ABCC1,CXCL14,ITGAV,CYBB,STAB1,TP53,PTX3,MIF,SPP1,RAC1,NINJ1,IL1RN,SH2B3,IL10RA,ALCAM,PLTP,CYR61,C3AR1,SIRPA,APOE,ADAM17,LITAF,LEP,ADIPOQ,HIF1A,CD74,IL17RA,HMOX1,CES1,GBA,EDN1,PTPRJ,TIMP1,FLNA,THBS1,ANXA1,DUSP10,SAA1,KIT,ADORA1,MAPKAPK2,HCAR2,NFE2L2,NLRC4,PRNP,CCR1,RPS19,CD209,TYROBP,NQO1,ENG,PLXND1,CSF1R,APP,ITGB2,GLIS2,TREM2,C6,P2RX7	67	
Cellular Function and Maintenance, Hematological System Development and Function	engulfment	engulfment of myeloid cells	1.73E-07	Increased	4.313	bias	1.962	GAB2,AGER,MSR1,HYOU1,SMPD1,BIN1,FAS,CXCL10,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	34	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	smooth muscle tumor	smooth muscle tumor	2.03E-07	 	 	 	 	SOCS3,AHCYL1,RPE,MEGF9,MAF,LHCGR,RAB9A,MT-CO2,CXCL14,RPL19,WNT5B,TP53,SLC2A5,CAPN6,PSMA6,DPT,PLD3,SPP1,SLC24A3,FGFR2,HMGA1,AP2S1,PIK3R3,KCNG1,ADAM12,ALDOA,SFRP1,INSR,CYR61,ESR2,RORB,FTH1,S100A11,PHLDA2,FGF2,SLC7A1,PLPP1,RAMP2,FAS,JUN,VCP,TOP2A,KIT,CFH,PI4KA,RPS19,DLGAP4,DVL1,SLC5A3,CSF1R,STXBP6,FOS,RPS15,NR4A2,PCCA,NR4A1,NR5A2,DCX,ADRA1A	59	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of membrane lipid derivative	2.06E-07	Increased	4.354	bias	1.466	SOCS3,PLCB2,APOB,PMVK,ARF1,PIK3R1,VAC14,SH3GLB1,CERS2,CXCL10,POR,SGPL1,IP6K3,GLB1,ABCC1,PIK3CG,MTMR2,DPM3,NSMAF,CERS6,PTX3,GM2A,RAC1,ARSA,GPAA1,PLAA,SERINC2,PIP5K1C,MAPK10,RARRES3,PLEK,B3GNT5,PLTP,CNBP,SCD,APOE,LEP,FGF2,PDGFA,DPM2,ADIPOQ,HEXA,SMPD1,FAS,HMOX1,CES1,GBA,EDN1,ANXA1,SAA1,KIT,PI4KA,ALDH5A1,MBOAT7,FCGR2A,G6PD,AGPAT1,SPTLC3,CSF1R,PLA2G2A,DEGS1,FGF1,APP,FOS,ITGB2,ENO1,APLP2,SREBF2,PPT1,FECH,PSAP,P2RX7	72	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	fatty acid metabolism	2.35E-07	Increased	3.503	bias	0.293	APOB,AGER,HRAS,POR,SGPL1,CTSS,ABCC1,TXN,TP53,ATP5J,CERS6,MSMO1,HSPA8,PLAA,AACS,PRELID1,RTN4,ME2,PLTP,ESR2,EPHX1,APOE,FGF2,GDF15,ADIPOQ,SLC1A3,CRAT,TECR,CD74,CES1,GBA,TNXB,PLIN2,HCAR2,ALDH5A1,CD209,FCGR2A,EGR1,ALOX5AP,SLC25A1,TRIB3,PLA2G2A,APP,MYO5A,FCER1G,PSAP,TSPO,ABCC3,NCAM1,NPC2,SOCS3,AKR1C3,CD4,FCER1A,PCCB,CERS2,HOXA10,ITGAV,GPC1,MDH2,NSMAF,ACSL3,MIF,GLYAT,GM2A,RAC1,ARSA,IL1RN,MAPK10,CD14,ACOT4,AKR1B1,CYP4A11,SCD,SDHB,LEP,MSR1,MECR,PKM,CD83,SMPD1,ME1,FAS,IRAK1,HMOX1,EDN1,PARK7,SAA1,ANXA1,KIT,S100A8,PRNP,AKR1C1/AKR1C2,SLC9A3R1,SNTB1,NQO1,MAPK9,SOD1,DEGS1,GIPR,PCCA,APOC1,P2RX7	103	
Nucleic Acid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of purine nucleotide	2.41E-07	Increased	2.034	bias	-0.001	APOE,SOCS3,ATP5G1,ATP5D,CHCHD10,AGER,PKM,NME2,COASY,HIF1A,ME1,FAS,NNMT,HMOX1,ALDH2,AK1,G0S2,UQCC2,VCP,NMNAT2,MT-CO3,LONP1,TP53,MT-ATP6,UCP2,LETM1,USMG5,SURF1,G6PD,SOD1,APP,MAPT,ALDOA,PANK3,CYCS,INSR,SLC25A5,VDAC1	38	
Cell Death and Survival	cell death	cell death of neuroblastoma cell lines	2.47E-07	 	0.570	 	0.728	PEBP1,APOE,LEP,ITSN1,DDIT3,FGF2,MBP,CCT2,FKBP1A,HSPA5,FAS,JUN,PARK7,UBE2K,CCT5,OAZ1,TXN,GPC1,CFH,RET,ATP13A2,PRNP,TP53,PRKRA,SPP1,TNFRSF10B,HSPA9,RAC1,MAPK9,SOD1,HMGA1,APP,HSPA8,ENO1,MAPT,PPT1,GAPDH,CYCS,CAPN2,SQSTM1,NCAM1	41	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of leukocytes	2.55E-07	Increased	4.750	bias	1.252	SOCS3,PFN1,AGER,CD4,CTSG,CXCL9,CXCL10,PTPRC,CD28,PIK3CG,CXCL14,CYBB,TXN,C1QBP,AIF1,TMSB10/TMSB4X,LCP1,MIF,SPP1,RAC1,FLOT1,CAPG,TPSAB1/TPSB2,NINJ1,PREX1,YARS,PIP5K1C,ACKR3,C3AR1,CD151,APOE,LITAF,ADAM17,DAPK2,LGALS9,PPIA,CD74,S100A7,HLA-G,EDN1,PTPRJ,THBS1,ANXA1,SAA1,CCL28,TGFB2,S100A8,STIM1,ADORA1,MAPKAPK2,HCAR2,PRNP,CCR1,RPS19,THBS4,FCGR2A,GNA12,MAPK9,GIT1,CSF1R,APP,GRN,CXCL16,ITGB2,MT-ND1,FCER1G,NCKAP1L	67	
Free Radical Scavenging	generation	generation of reactive oxygen species	2.68E-07	 	0.426	 	-0.626	SOCS3,CRYAB,LEP,ITSN1,AGER,PIK3R1,ADIPOQ,TLR8,PPIA,HRAS,RPL26,FAS,SCO2,CD28,HMOX1,ALDH2,EDN1,PIK3CG,CXCL14,CYBB,TPO,CFH,CLCN3,NFE2L2,CBR1,TP53,MIF,VCAM1,UCP2,FCGR2A,RPL29,RAC1,SDHC,SOD1,CSTB,TXNRD1,APP,FOS,SREBF2,GABARAP,AKR1B1,C3AR1,GSTP1,HSPB1	44	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of phagocytes	2.74E-07	Increased	3.708	bias	1.587	GAB2,AGER,BIN1,FAS,CXCL10,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,ANXA5,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	32	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of blood cells	2.88E-07	Increased	3.940	bias	1.701	GAB2,AGER,MSR1,BIN1,FAS,CXCL10,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,GULP1,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,RAC1,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	35	
Inflammatory Response	inflammation	inflammation of organ	2.92E-07	 	-0.736	 	1.434	TGFBR1,AGER,PIK3R1,CA5B,C1QA,CXCL9,ODC1,POR,PTPRC,ATF4,TP53,TNFRSF10B,MAD2L2,FLOT1,TPM3,FGFR2,BRF2,IRF5,DSG1,MYL9,CTSB,ALCAM,GAPDH,SQSTM1,ESR2,APOE,GADD45B,DDIT3,ADIPOQ,HLA-DQA1,PPIA,LGALS9,CD74,PTPRJ,ADORA1,NFE2L2,FCGR3A/FCGR3B,KRT10,P4HA2,CCR1,SIGMAR1,FCGR2A,TUBB4B,IGKC,DGAT2,NR4A2,PPT1,NR4A1,PSAP,KRT6A,ARHGDIA,ADRA1A,SOCS3,TRAF3,MBP,TLR8,FCER1A,TYMP,STARD7,HSPA5,CD28,HS6ST1,CTSD,ENTPD5,STAB1,TUBA1C,MUCL1,CBR1,TOP3B,IL2RG,HNRNPAB,CAPG,KLF4,SPINK5,NAGLU,INSR,CST6,TNS1,CD151,UBE2I,SCD,F2RL3,IL17RA,IRAK1,SLC19A3,ALDH2,EDN1,TIMP1,CFH,STAT1,KRT14,VCAM1,CAPZB,NQO1,TUBG1,SOD1,S100A2,NFE2L1,CXCL16,PSMD2,APOB,PLIN1,NCSTN,MKI67,HLA-DQB1,APRT,CXCL10,SGPL1,LGMN,CTSS,PIK3CG,GAA,PNKD,NAPA,CFL1,TUBB2A,NINJ1,MNT,PSMB2,IL10RA,ALDOA,CYR61,C3AR1,GSTP1,LCP2,FCGRT,S100A11,ADAM17,HLA-A,FKBP1A,ASNS,UCHL1,PIP,S100A7,CA3,JUN,MT-CYB,ANXA5,HLA-DRA,TOP2A,STIM1,TYROBP,EGR1,KRT5,PLA2G2A,APP,ITGB2,GLIS2,SREBF2,TREM2,MS4A2,FKBP4,FCER1G,P2RY12,NR5A2,PER1,CD4,LHCGR,TUBB,IFI30,CYBB,NEO1,ANXA7,LANCL1,RET,MIF,SPP1,TRIOBP,RAC1,CPVL,PKN1,EFS,PREX1,IL1RN,MAPT,CD14,LEP,CD2,PKM,SMPD1,HIF1A,FAS,TNFRSF12A,HMOX1,FLNA,THBS1,DUSP10,ANXA1,VCP,KIT,S100A8,MAPKAPK2,NLRC4,MAPK9,CSF1R,ENO1,C6	197	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of phagocytes	2.96E-07	 	1.096	bias	-1.019	TRAF3,AGER,CD4,MAF,TLR8,STARD7,CD63,CXCL10,ITGAV,CYBB,TP53,MIF,SPP1,TNFRSF10B,ANXA2,KLF4,SPON2,OSTM1,PREX1,IL1RN,MAPT,SLC7A2,CD14,CLCN7,SFRP1,SIRPA,LCP2,APOE,GJB6,LEP,TOLLIP,MSR1,DDIT3,HLA-A,ADIPOQ,HSPB8,LGALS9,PPIA,FKBP1A,FAS,IRAK1,TNFRSF12A,S100A7,HMOX1,EDN1,THBS1,DUSP10,SAA1,ANXA1,KIT,S100A8,CFH,STAT1,ADORA1,PRNP,CD209,TYROBP,FCGR2A,SOD1,CSF1R,PLA2G2A,APP,GRN,ITGB2,TREM2,PPT1,FCER1G,C6,P2RX7	69	
Gene Expression	expression	expression of RNA	3.03E-07	 	1.222	 	-1.001	CRYAB,TGFBR1,WHSC1,KDM6B,AGER,PIK3R1,NPAS2,POLRMT,SLC9A1,ODC1,GNB1,GATAD2A,CCND3,EIF3B,ARID3B,AJUBA,KEAP1,ATF4,LMX1A,MYBBP1A,AIF1,TP53,BCOR,PPP1R1B,KLHL25,TNFRSF10B,MAD2L2,FGFR2,IRF5,HAX1,HSPA8,ATXN7L3,MRPL17,BTG2,GAPDH,DUSP4,SQSTM1,NHLH1,ESR2,DEAF1,RPL41,KDM1B,MT-TL1,BANK1,RAP2A,APOE,NME1,NACC2,DDIT3,FGF2,ADIPOQ,LGALS9,OGT,DAB2,ASPH,NFE2L2,CCR1,S100A1,SRA1,MT-TY,FCGR2A,GNA12,MESP1,ENG,TRIB3,GRN,FOS,AFF3,MYOC,NR4A2,PIR,NTRK3,MBD3,MAZ,NR4A1,WBP2,RPL37,SOX9,SIM1,DCX,SOCS3,TRAF3,YWHAH,MBP,TLR8,NME2,OGFOD1,CEBPG,CD28,HSPA4,HSF4,RHOG,EIF3D,STC2,HOXA10,HOXA7,PPP1CA,CHMP1A,IL2RG,HNRNPAB,BAMBI,PFDN5,MT-TC,CREG1,POLR2K,MT-TE,CITED1,KLF4,TXNRD1,FOSB,AES,RBX1,H1F0,INSR,CCPG1,CBX3,UBE2I,HSPB1,ETV5,PEBP1,PTGFR,LITAF,NELFB,ZNF219,DMD,HNRNPK,IRAK1,FARSB,HDGF,EDN1,TIMP1,MT-TS1,STOX1,TOX2,STAT1,PREB,VCAM1,MT-TQ,TUBG1,DVL1,NQO1,CSRNP1,DNAJC1,RPS29,NRBF2,NFE2L1,FGF1,RBCK1,POLR2G,KCTD13,DGKQ,CXXC5,EIF3I,GZF1,MAP4K4,APOB,MAF,HRAS,DDX20,GSS,GLO1,EEF1D,SNX12,CXCL10,ZBTB7B,MKX,POU6F2,CHCHD2,TXN,ZBTB16,POLR2I,SFRP4,NANOS1,CKAP2,HMGA1,MNT,MTPN,NR1D1,ARHGAP35,RAMP3,SFRP1,TCF7,CYR61,RORB,GSTP1,LCP2,HIST1H1C,MSC,RPS3A,TCEA1,PSMB10,BTG3,FKBP1A,RCOR2,MRPL39,H2AFZ,SLBP,MAFG,PIP,DCLK2,JUN,SEC61A1,TOP2A,TRIM16,TUB,PSMD14,NACC1,RPS5,SARS,ACVR1C,MT-TD,RPS24,PTPRK,EGR1,EPB41L4B,TRIM28,RPL17,CSRNP2,RNASEK,APP,HIST1H1B,EIF3G,MCF2L,MRPL51,CCDC85B,GLIS2,SOX6,SREBF2,USP22,RNF187,MMS19,PEA15,PRMT5,NR5A2,DVL3,CBX4,MAPRE3,NCAM1,HOXB5,GAB2,PER1,MT-TT,PFN1,CD4,XPO5,LHCGR,UTP4,TAF10,ZNF91,MTCH2,CTBP1,CAMK2D,RPL19,NEO1,KPNA2,ANXA7,C1QBP,RET,EIF2AK1,MIF,SPP1,GPS2,LMO4,GNG2,PHB2,RAC1,PKN1,RASD1,EPRS,LMCD1,ERP29,SH2B3,MAPK10,RARRES3,CNBP,MT-TP,SPX,LEP,ATF5,PDGFA,ERN1,VAPA,HIF1A,RAMP2,RPS4X,FAS,MT-TN,NELFE,HINT1,PARK7,FLNA,TGFB2,KIT,ARHGEF2,SLC40A1,NR2F6,SOX18,KCTD1,MAPKAPK2,NACA,DAP,TAF6,BHLHE41,HSPH1,RPL30,MAPK9,NDUFA13,EDF1,ENO1,WARS,RPS27L,UTP15,CPEB1,HLTF,P2RX7,CARM1,RPL38	317	
Cardiovascular System Development and Function, Organismal Development	angiogenesis	angiogenesis	3.05E-07	 	1.938	bias	-0.737	CRYAB,TGFBR1,APOB,AGER,PIK3R1,HRAS,COL8A1,C1QA,HLA-DQB1,CXCL9,ODC1,SPRY4,CXCL10,POR,SGPL1,GATAD2A,SRPX2,CTSS,PIK3CG,ARHGEF26,MGAT1,TP53,YWHAG,PAQR3,FGFR2,ANXA2,ANGPTL1,YARS,RTN4,CTSB,ALCAM,CYR61,ITGA7,C3AR1,APOE,PIM3,DDIT3,GBP1,FGF2,SNX17,ADIPOQ,PPIA,COL15A1,OGT,JUN,PTPRJ,CCL28,DAB2,STIM1,SARS,AMOT,NFE2L2,PLOD3,EGR1,MESP1,ENG,APP,GRN,FOS,ITGB2,MCF2L,KIF7,NR4A1,PSAP,CYCS,ARHGDIA,BMPER,SEMA3C,HOXB5,GAB2,SOCS3,SEPT9,CMA1,UNC5B,TYMP,SDC4,CD63,CD28,RSPO3,HS6ST1,RHOG,CXCL14,ITGAV,CYBB,STAB1,GCLM,GPC1,PTX3,PFKFB3,SPP1,STK39,RPL29,RAC1,CITED1,SPINK5,PDCL3,IL1RN,COMMD1,INSR,MEGF8,AKR1B1,HTRA1,CYP4A11,RPSA,HSPB1,CD151,IGFBP4,SPRED1,LEP,PDGFA,ERN1,PKM,SMPD1,HIF1A,PDGFC,RAMP2,FAS,TNFRSF12A,HMOX1,EDN1,TIMP1,THBS1,FLNA,KCNMA1,SAA1,TGFB2,KIT,RNH1,CYGB,S100A8,SOX18,CHCHD4,STAT1,MAPKAPK2,THBS4,VCAM1,G6PD,SOD1,CISD2,PLXND1,CSF1R,EDF1,FGF1,SHB,WARS,CAPNS1,CXXC5,EPHB3,C6,P2RX7	150	
Cell-To-Cell Signaling and Interaction	response	response of myeloid cells	3.09E-07	Increased	4.553	bias	2.581	GAB2,AGER,ERN1,CTSG,TLR8,FCER1A,BIN1,FAS,PTPRC,CXCL10,HMOX1,IGHG3,PARK7,PTPRJ,THBS1,ANXA1,PIK3CG,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,EIF2AK1,PTX3,TP53,SIGLEC1,MIF,VCAM1,UCP2,TYROBP,FCGR2A,CAPG,CMC2,ISG15,APP,ITGB2,TREM2,FCER1G,IL10RA,CD14,IGHA1,SIRPA,P2RX7	43	
Cancer, Organismal Injury and Abnormalities	metastatic solid tumor	metastatic solid tumor	3.25E-07	 	0.420	 	-0.001	TGFBR1,SLC7A11,AKR1C3,CSNK1A1,LHCGR,HRAS,NRN1,RNASE1,CXCL9,TUBB,PTPRC,POR,CYP3A5,PIK3CG,HOXA10,IFI30,TUBA1C,RET,TMSB10/TMSB4X,CLCN3,TP53,PTX3,IL2RG,SPP1,TNFRSF10B,TUBB2A,FGFR2,CAPG,HAX1,DYNLRB1,EFS,CCND2,ACKR3,IL1RN,GLUL,DUSP4,INSR,SFRP1,HTRA1,ESR2,STEAP3,GSTP1,S100A11,SCD,ERAP2,MSC,TCEA1,EPB41L3,STMN2,SRD5A1,PDGFA,DUSP6,GDF15,PPIA,FKBP1A,DMD,HIF1A,FAS,HMOX1,EDN1,THBS1,FLNA,TOP2A,TGFB2,LOC102724428/SIK1,KIT,RNH1,STAT1,ALPL,FCGR3A/FCGR3B,MYL12A,PRNP,VCAM1,NDUFB4,AKR1C1/AKR1C2,FCGR2A,TUBB4B,EPB41L4B,TUBG1,SLC5A3,CSF1R,ATIC,FGF1,FTL,CLGN,LGALS2,P2RY12,ABCC3,NCAM1	89	
Post-Translational Modification	phosphorylation	phosphorylation of protein	3.33E-07	Increased	2.943	bias	0.320	TGFBR1,AGER,PIK3R1,CTSG,HRAS,ODC1,PTPRC,DYNLL1,IP6K3,SRPX2,CCND3,PIK3CG,PLXNB2,AIF1,CFL1,PAQR3,FLOT1,FGFR2,ANXA2,HSPA8,CCND2,B3GNT5,SQSTM1,CYR61,RAP2A,NME1,ADAM17,PIM3,DAPK2,FGF2,DUSP6,CDK16,ADIPOQ,PPIA,FKBP1A,OGT,PTPRJ,AAK1,DAB2,TP53RK,ACVR1C,NDUFS4,CCR1,TYROBP,FCGR2A,TRIM28,ENG,HSPA2,APP,CALM1 (includes others),ITGB2,COL5A3,NTRK3,FAM129A,RSPO1,FCER1G,PSAP,STK31,SOX9,DVL3,PRKACB,SOCS3,SESN2,CD4,CSNK1A1,TLR8,NME2,CHST15,CTBP1,CD28,HSPA4,CAMK2D,RET,BCKDK,EIF2AK1,HK1,PRKRA,MIF,SPP1,STK39,RAC1,FYB,PKN1,SLC3A2,ERP29,SDCBP,MAPK10,INSR,PEBP1,LEP,TOLLIP,CD2,ERN1,BARD1,FAS,IRAK1,PARK7,EDN1,PPP1R9B,THBS1,ADCK3,TGFB2,LOC102724428/SIK1,KIT,MAPKAPK2,TSSK4,PRNP,DVL1,MAPK9,MKNK2,CSF1R,FGF1,SHB,PAG1,EPHB3,NCKAP1L,MAP4K4,P2RX7	118	
Cell-To-Cell Signaling and Interaction	binding	binding of cells	3.55E-07	Increased	3.653	bias	1.334	TGFBR1,AGER,CD4,PIK3R1,CCT2,CTSG,LHCGR,HRAS,SDC4,CXCL9,HSPA5,PTPRC,CXCL10,CD28,HS6ST1,ITGAV,CCT5,SLC7A5,STAB1,CDC42EP1,CNTNAP1,GPC1,SNU13,C1QBP,PTX3,IL2RG,SPP1,RAC1,ANXA2,ARSA,FYB,SLC3A2,ANGPTL1,CD68,STIP1,ALCAM,CD14,RAMP3,LFNG,INSR,CYR61,ITGA7,LCP2,RPSA,CD151,APOE,LEP,MSR1,CD2,FGF2,HLA-A,ADIPOQ,CD83,CKAP4,CD74,RAMP2,FAS,TNFRSF12A,JUN,THBS1,CCL28,ANXA5,TGFB2,SLC19A1,KIT,NFE2L2,FCGR3A/FCGR3B,PRNP,CCR1,SIGMAR1,CD209,VCAM1,MRC2,FCGR2A,IGKC,VANGL1,ENG,DNAJC1,FGF1,APP,ITGB2,CLGN,NR4A1,PRMT5,P2RY12	85	
Post-Translational Modification, Protein Folding	folding	folding of protein	3.56E-07	 	 	 	 	CRYAB,RAB7A,PPIA,SH3GLB1,QSOX1,FKBP1A,DNAJC1,TBCA,HSPA5,HSPA2,AIP,HSPA8,ERP29,PDIA6,PDCL3,ENTPD5,PIGK,FKBP4,AARS,TXN,CHCHD4,FKBP5,HSPB1	23	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of granulocytes	3.60E-07	Increased	3.773	bias	 	AGER,DAPK2,CTSG,LGALS9,CD74,CXCL9,S100A7,CXCL10,CD28,EDN1,ANXA1,CCL28,PIK3CG,CXCL14,TGFB2,S100A8,STIM1,C1QBP,TMSB10/TMSB4X,ADORA1,MAPKAPK2,RPS19,THBS4,SPP1,FCGR2A,RAC1,MAPK9,FLOT1,CAPG,TPSAB1/TPSB2,APP,GRN,ITGB2,MT-ND1,PREX1,PIP5K1C,YARS,FCER1G,NCKAP1L,C3AR1,CD151	41	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	homing	homing of leukocytes	3.72E-07	Increased	4.814	bias	1.310	SOCS3,PFN1,AGER,CD4,CTSG,CXCL9,CHST2,CXCL10,PTPRC,CD28,PIK3CG,CXCL14,CYBB,TXN,C1QBP,AIF1,TMSB10/TMSB4X,LCP1,MIF,SPP1,RAC1,FLOT1,CAPG,FYB,TPSAB1/TPSB2,NINJ1,PREX1,YARS,PIP5K1C,ACKR3,C3AR1,CD151,APOE,LITAF,ADAM17,DAPK2,LGALS9,PPIA,CD74,S100A7,HLA-G,EDN1,PTPRJ,THBS1,ANXA1,CCL28,SAA1,TGFB2,S100A8,STIM1,ADORA1,MAPKAPK2,HCAR2,PRNP,CCR1,RPS19,THBS4,FCGR2A,GNA12,NQO1,MAPK9,GIT1,CSF1R,APP,GRN,CXCL16,ITGB2,MT-ND1,FCER1G,NCKAP1L	70	
Cellular Movement	migration	migration of tumor cell lines	3.81E-07	Increased	5.120	bias	1.959	WHSC1,TGFBR1,AGER,PIK3R1,HRAS,CXCL9,CXCL10,DGCR6L,SRPX2,PIK3CG,KEAP1,AFAP1,TP53,SFRP4,TPM3,FGFR2,ANXA2,ARHGDIB,NINJ1,HAX1,CTSB,ALCAM,CYR61,ESR2,RAP2A,NME1,ADAM17,OSGIN1,FGF2,GDF15,ADIPOQ,SDC3,ASNS,SYNM,ENAH,S100A7,JUN,DAB2,STIM1,ASPH,NFE2L2,CALML3,PLXNA1,PTPRK,GNA12,EGR1,IPO7,ENG,SNCG,APP,GRN,MCF2L,NR4A2,NTRK3,FLNC,WBP2,PRMT5,SOX9,NCAM1,GAB2,SOCS3,SEPT9,ARF1,USP5,SDC4,CTBP1,RHOG,ITGAV,KPNA2,C1QBP,SHOC2,MIF,SPP1,PCSK6,PHB2,RAC1,KLF4,PKN1,LMCD1,PREX1,SDCBP,ADAM12,ACKR3,CAPN2,CST6,SIRPA,UBE2I,ETV5,CD151,IGFBP4,LEP,F2RL3,PDGFA,PLGRKT,PKM,HIF1A,HNRNPK,CLCN4,HDGF,HMOX1,EDN1,TIMP1,FLNA,THBS1,ANXA1,VCP,KIT,S100A8,IGSF8,STAT1,MAPKAPK2,PRNP,NDUFAF3,VCAM1,SLC9A3R1,BHLHE41,SLC12A2,MAPK9,GIT1,CSF1R,FGF1,CAPNS1,MAP4K4	123	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	leiomyomatosis	leiomyomatosis	3.97E-07	 	 	 	 	SOCS3,AHCYL1,RPE,MEGF9,MAF,LHCGR,RAB9A,MT-CO2,CXCL14,RPL19,WNT5B,SLC2A5,CAPN6,PSMA6,DPT,PLD3,SLC24A3,FGFR2,AP2S1,PIK3R3,KCNG1,ADAM12,ALDOA,SFRP1,INSR,CYR61,ESR2,RORB,FTH1,S100A11,PHLDA2,FGF2,SLC7A1,PLPP1,RAMP2,FAS,JUN,VCP,KIT,CFH,PI4KA,RPS19,DLGAP4,DVL1,SLC5A3,CSF1R,STXBP6,FOS,RPS15,NR4A2,PCCA,NR4A1,NR5A2,DCX,ADRA1A	55	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of leukocytes	4.01E-07	Increased	3.933	bias	1.687	GAB2,AGER,MSR1,BIN1,FAS,CXCL10,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	33	
Cancer, Organismal Injury and Abnormalities	neoplasia	neoplasia of epithelial tissue	4.10E-07	 	-0.364	 	0.077	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,TMEM123,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,LHFPL2,HS6ST1,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,MT-ND2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,RBX1,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,VAT1,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,C15orf59,RPLP0,TUBA1B,GFPT1,SNTA1,ITGA8,HLA-DQB1,MIEN1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,H2AFZ,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,NAP1L4,CD209,RRP1B,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,ANKMY2,FAM45A,RPL12,ATP10A,SLC39A3,GALNT13,TARS,ATP6V1A,TPSAB1/TPSB2,PREX1,TMEM189,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,RPS21,KIFAP3,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,SLCO2B1,MRPL24,DPT,PLD3,LHPP,ICT1,MTSS1,KLHL25,PAQR3,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,ZNF69,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,MRPL17,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,SDHAF1,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,BZW2,TRAF3,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,RNASE1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,UBA6,ARSA,MT-ND4L,GYS2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,SPCS1,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,SERINC2,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,MT-ND3,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,PSMB10,PAM16,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,TAX1BP3,CA3,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,LAMP1,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,ADCK2,PEA15,PRMT5,P2RY12,SCAMP3,RUFY3,MAPRE3,MVD,GAB2,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,LMO4,GPS2,ANLN,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,SURF1,IRF5,CTSB,C15orf39,NHLH1,PLTP,FTH1,EPHX1,CD163L1,EVA1B,GADD45B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,SLC25A1,ENG,MAGEC3,MYO5A,RPS16,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,UBE2I,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,FARS2,STAT1,MT-CO1,THBS4,PREB,TRIM55,IPO4,G6PD,TSN,KIF3B,APOLD1,APLP2,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,GSS,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,DHRSX,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,MYL12A,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,SLC48A1,CCDC85B,GLIS2,BRINP2,RHBDD2,TREM2,USP22,APOL4,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,C1QBP,RET,MDH2,BCKDK,C7orf50,MRPS15,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PACSIN3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,RAC1,CPVL,GPAA1,RASD1,C9orf16,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,TBCB,RRAGD,OAZ1,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,KIAA1683,ACSM2B,PLBD2,TMEM2,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,RHBDD1,BRF2,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,PRELP,UCK1,MARCH4,TULP3,LYPLA1,TMEM33,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,CD74,ZNF827,SLC35B2,GLIPR1,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,LURAP1L,TTC23,FAM96B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,WDR36,TMC2,SRA1,TRIB3,HSPA2,SPTLC3,GRN,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,SEMA3C,TSC22D2,TTYH3,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,KRTAP4-6,RHOG,ZNRF3,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,C17orf53,CBR1,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,SLC25A39,CDH20,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SYCE1,SF3B5,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,SHB,CIDEA,KIFC3,KIF5B,TTL,EIF3I,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,TOR1A,TXNL4A,SH3BGRL3,HRAS,NCSTN,CECR1,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,PTPA,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,PIP,FANCE,UCHL1,RPL35,ACSM5,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,SLC7A6,NDUFS4,MBOAT7,LETM1,ADRM1,TYROBP,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,RAB9A,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,TNFRSF12A,SEPHS2,HMOX1,RNF167,PARK7,PCK2,KCNMA1,NDUFC2,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,COX17,CD160,VANGL1,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,RTN3	1295	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of macrophages	4.11E-07	 	 	 	 	APOE,MSR1,GDF15,UNC5B,FCER1A,PPIA,IRAK1,CXCL10,LGMN,PIK3CG,TGFB2,CYBB,CLCN3,STAT1,NLRC4,CCR1,SIGMAR1,LCP1,SPP1,UCP2,TYROBP,NPY1R,FCGR2A,EGR1,MAPK9,CAPG,CSF1R,GRN,FOS,TREM2,FCER1G,CNPY3,CD14,PSAP,DUSP4,SIRPA,P2RX7,HSPB1	38	
Cellular Function and Maintenance	function	function of leukocytes	4.33E-07	 	-0.091	 	-0.927	GAB2,PLCB2,TRAF3,CMA1,PIK3R1,CD4,UNC5B,FCER1A,TLR8,HLA-DQB1,PANX1,CEBPG,CHST2,PTPRC,CXCL10,CD28,BCAT1,LGMN,RHOG,CTSS,ABCC1,PIK3CG,CYBB,IFI30,CLCN3,NSMAF,TBC1D10C,TP53,LCP1,MIF,IL2RG,SPP1,RAC1,FLOT1,CAPG,IRF5,FYB,ARHGDIB,PKN1,NINJ1,EFS,IL10RA,CNPY3,CD14,DUSP4,EIF5A,TCF7,C3AR1,SIRPA,HSPB1,BANK1,APOE,SPRED1,GADD45B,LEP,MSR1,PSMB10,HLA-A,GDF15,ADIPOQ,LGALS9,PPIA,SMPD1,CD74,IRAK1,HLA-G,PTPRJ,TGFB2,KIT,STAT1,NLRC4,CCR1,PLXNA1,SIGMAR1,CD209,UCP2,TYROBP,FCGR2A,NPY1R,EGR1,MAPK9,TRIB3,CSF1R,IL20RB,GRN,FOS,ITGB2,TREM2,FCER1G,MS4A2,PSAP,ARHGDIA,P2RX7	93	
Endocrine System Disorders, Organismal Injury and Abnormalities	thyroid nodule	thyroid nodule	4.50E-07	 	 	 	 	MT-ND5,MT-ND1,PARK7,PRDX5,ANXA5,CTSB,TPO,MT-ND2,GSTP1,APP	10	
Organismal Survival	survival	survival of organism	4.54E-07	 	1.219	bias	-1.148	CRYAB,TGFBR1,AGER,PCLO,ITSN1,HRAS,MKI67,CXCL9,ODC1,CXCL10,PTPRC,PIK3CG,ABCC1,KEAP1,MGAT1,TP53,RHEB,ARRDC4,PPP1R1B,MAD2L2,IRF5,ARHGDIB,CCND2,STIP1,CTSB,GLUL,DUSP4,PLTP,B3GNT5,ESR2,C3AR1,ITGA7,GSTP1,FCGRT,APOE,NME1,HYOU1,LGALS9,CD74,LYZ,HLA-DRA,TOP2A,LAMP1,SLC19A1,ADORA1,NFE2L2,FCGR3A/FCGR3B,ALDH5A1,CCR1,S100A1,UCP2,FCGR2A,GNA12,KRT5,ENG,SNCG,PLA2G2A,APP,FOS,FTL,NTRK3,TREM2,USP22,PEA15,CYCS,ARHGDIA,GABARAP,NCAM1,SOCS3,SLC31A1,SESN2,CD4,ABCA3,CD28,CYP3A5,CYBB,HOXA7,SIAH2,RET,NSMAF,TOP3B,PTX3,MIF,IL2RG,SPP1,RAC1,IL1RN,MAPT,CNPY3,CD14,LFNG,INSR,LITAF,LEP,CD2,F2RL3,PKM,DMD,SMPD1,RAMP2,FAS,IRAK1,ALDH2,HMOX1,THBS1,ANXA1,KIT,SLC40A1,STAT1,MAPKAPK2,NLRC4,PRNP,KRT14,COL5A2,MAPK9,SOD1,SNX27,GIT1,PCCA,SLC14A1,SLC1A2	121	
Neurological Disease	degeneration	degeneration of central nervous system	4.71E-07	Decreased	-2.087	bias	0.160	ADIPOQ,SLC1A3,VAC14,SMPD1,JUN,GBA,GLB1,CYBB,NMNAT2,CLCN3,STAT1,ADORA1,NFE2L2,UNG,NDUFS4,PRNP,TP53,ASNA1,SOD1,ARSA,NFE2L1,APP,MAPT,PPT1,CTSB,TPP1,PSAP,SLC1A2,NAGLU,CLCN7,SQSTM1	31	
Cellular Movement	invasion	invasion of cells	5.34E-07	Increased	3.939	bias	0.863	TGFBR1,WHSC1,KDM6B,AGER,PIK3R1,HRAS,SLC9A1,ODC1,MIEN1,CXCL10,BCAT1,LGMN,CTSS,PIK3CG,KEAP1,ARHGEF26,TMSB10/TMSB4X,ZBTB16,WNT5B,TP53,LCP1,FGFR2,ANXA2,HMGA1,HAX1,CTSB,ALCAM,SFRP1,SQSTM1,CYR61,LYPLA1,ESR2,NME1,ADAM17,GBP1,FGF2,DUSP6,GDF15,ADIPOQ,FKBP1A,ENAH,S100A7,CA3,JUN,PTPRJ,DAB2,ASPH,NFE2L2,PLOD3,CCR1,CD53,PTPRK,EGR1,GNA12,ENG,IPO7,SNCG,APP,GRN,FOS,ITGB2,NR4A2,NTRK3,TREM2,NR4A1,WBP2,ARHGDIA,SOX9,GAB2,TRAF3,SEPT9,UNC5B,NME2,SDC4,HSPA5,CTBP1,CTSD,RHOG,ENTPD5,ITGAV,GPC1,C1QBP,RET,MIF,SPP1,GSDMB,PCSK6,RAC1,HNRNPAB,CITED1,KLF4,SEL1L,SDCBP,ADAM12,ACKR3,CD14,CAPN2,CST6,HTRA1,TMEM176B,RPSA,ETV5,CD151,PEBP1,ATP6V0C,LEP,PDGFA,PLGRKT,PKM,SMPD1,HIF1A,FAS,CLCN4,HDGF,HMOX1,PARK7,EDN1,TIMP1,THBS1,FLNA,KCNMA1,ANXA1,SAA1,VCP,TGFB2,RNH1,RHOBTB2,S100A8,STAT1,MAPKAPK2,ADAMTS15,VCAM1,SLC9A3R1,BHLHE41,SLC12A2,VANGL1,NQO1,GIT1,SERPINE2,CAPNS1,CLDN1,PAG1,MAP4K4	143	
Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism	quantity	quantity of Ca2+	5.58E-07	Increased	2.550	bias	-0.278	PLCB2,ATP2B1,PIK3R1,FCER1A,HRAS,CXCL9,HSPA5,PANX1,SLC9A1,GNB1,CXCL10,PTPRC,CD28,CAMK2D,PLCE1,MCOLN3,PIK3CG,CPM,C1QBP,TP53,SPP1,LAIR1,PPP1R1B,ANXA2,TPSAB1/TPSB2,ADCYAP1R1,MAPT,INSR,VDAC1,C3AR1,LCP2,BANK1,PTGFR,APOE,LEP,F2RL3,CD2,FGF2,HYOU1,PPIA,FKBP1A,SMPD1,FAS,LYZ,EDN1,PPP1R9B,PTPRJ,SAA1,S100A8,STIM1,ADORA1,FCGR3A/FCGR3B,PRNP,CCR1,S100A1,SIGMAR1,VCAM1,SLC9A3R1,FCGR2A,IGKC,SLC12A2,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,FCER1G,MS4A2,P2RX7,ADRA1A,NCAM1	73	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	follicular thyroid tumor	follicular thyroid tumor	5.61E-07	 	 	 	 	TGFBR1,SPP1,HRAS,MT-ND4,FGFR2,ENG,CSF1R,NDUFA13,MT-ND1,PARK7,THBS1,SRGAP1,TIMP1,ANXA5,CTSB,KIT,TPO,INSR,RET,AMOT,GSTP1	21	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of ganglioside	5.66E-07	 	-1.041	bias	 	GBA,GLB1,GM2A,PSAP,HEXA,SMPD1,FAS,NPC2	8	
Cell Death and Survival	degradation	cellular degradation	5.73E-07	Decreased	-2.301	bias	0.020	CRYAB,SLC9A1,CERS2,CTSD,MTMR2,CLCN3,RET,UNG,STXBP1,PTPRQ,RAC1,FGFR2,ARSA,IL1RN,MAPT,CTSB,NAGLU,SQSTM1,ESR2,APOE,UBQLN1,DNASE1L3,FGF2,SLC1A3,SMPD1,HIF1A,MAFG,UCHL1,LYZ,JUN,PARK7,KCNMA1,TGFB2,TUB,PRNP,NDUFS4,TYROBP,SOD1,CISD2,CSF1R,KCNQ4,APP,GRN,NR4A2,NTRK3,PPT1,PSAP,TPP1,SLC1A2,C6,NCAM1	51	
Cancer, Organismal Injury and Abnormalities	abdominal neoplasm	abdominal neoplasm	7.27E-07	 	1.388	 	2.008	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,PIM3,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,TMEM123,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,LHFPL2,HS6ST1,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,RPLP0,GFPT1,SNTA1,ITGA8,HLA-DQB1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,ATP6AP1,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,NAP1L4,CD209,RRP1B,ANKRD9,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,GOT1,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,ANKMY2,FAM45A,RPL12,ATP10A,GALNT13,SLC39A3,TARS,TPSAB1/TPSB2,PREX1,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,KIFAP3,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,DPT,PLD3,ICT1,LHPP,MTSS1,PAQR3,TNFRSF10B,MAD2L2,CARMIL1,RUNDC3B,ZNF69,CD52,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,MRPL17,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,BZW2,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,SDHC,UBA6,ARSA,MT-ND4L,GYS2,FOSB,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,CDK16,CTNNA1,ACSF2,PFKL,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,PEA15,PRMT5,P2RY12,SCAMP3,RUFY3,MAPRE3,HOXB5,MVD,GAB2,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,GPS2,ANLN,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,PRDX5,PDGFA,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,SURF1,IRF5,CTSB,C15orf39,PLTP,FTH1,EPHX1,CD163L1,EVA1B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,IGKC,SLC25A1,ENG,MAGEC3,MYO5A,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,UBE2I,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,FARS2,STAT1,MT-CO1,THBS4,PREB,TRIM55,IPO4,DVL1,G6PD,TSN,APOLD1,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,AP2S1,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,SLC48A1,GLIS2,RNF144A,BRINP2,RHBDD2,TREM2,USP22,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,RILP,HIST1H4H,RET,DHX32,MDH2,BCKDK,C7orf50,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PSMA6,PACSIN3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,RAC1,CPVL,GPAA1,RASD1,C9orf16,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,RRAGD,OAZ1,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,KIAA1683,ACSM2B,PLBD2,TMEM2,APOC1,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TSPYL5,TMEM201,PPTC7,FGFR2,TIMM8B,TPM3,FLOT1,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,GAPDH,UCK1,MARCH4,TULP3,TMEM33,LYPLA1,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,ZNF827,CD74,SLC35B2,GLIPR1,LAMP3,COL16A1,SHTN1,SORBS1,OSBPL11,TTC23,ALDH5A1,FCGR3A/FCGR3B,G3BP2,TMC2,WDR36,SRA1,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,TSC22D2,TTYH3,SEMA3C,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,KRTAP4-6,RHOG,ZNRF3,ENTPD5,ELP5,CDC42EP1,GCLM,CHMP1A,C17orf53,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,SLC25A39,CDH20,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SYCE1,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,CXCL16,SHB,CIDEA,LGALS2,KIF5B,TTL,EIF3I,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,TOR1A,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,NANOS1,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,PIP,FANCE,UCHL1,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,SLC7A6,NDUFS4,MBOAT7,LETM1,ADRM1,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,GABARAP,ACTR1A,EFR3A,MT-TT,SLC7A11,XPO5,RAB9A,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,SEPHS2,HMOX1,RNF167,PCK2,NDUFC2,KCNMA1,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,CD160,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1263	
Connective Tissue Disorders, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	polyarthritis	polyarthritis	7.76E-07	 	1.360	 	1.027	APOE,GADD45B,DDIT3,ERN1,HSPB8,CD83,CD74,IL17RA,FAS,HLA-G,PTPRC,THBS1,CTSS,ANXA1,PIK3CG,HLA-DRA,S100A8,TXN,STAT1,MAPKAPK2,PRNP,TP53,RPL32,CCR1,SPP1,NQO1,F13A1,FOSB,FOS,NR4A2,IL1RN,NR4A1,SLC1A2,HTRA1,P2RX7,RPSA	36	
Cellular Movement	chemotaxis	chemotaxis	7.77E-07	Increased	5.070	bias	1.094	SOCS3,TGFBR1,PFN1,AGER,CD4,CTSG,HRAS,TYMP,CXCL9,GNB1,PTPRC,CXCL10,CD28,RHOG,ABCC1,PIK3CG,CXCL14,CYBB,ITGAV,HOXA7,TXN,C1QBP,AIF1,TMSB10/TMSB4X,CLCN3,LCP1,MIF,SPP1,RAC1,FLOT1,CAPG,ANXA2,NINJ1,TPSAB1/TPSB2,PREX1,ACKR3,PIP5K1C,YARS,RTN4,CAPN2,CYR61,ELMO2,C3AR1,SIRPA,CD151,APOE,ADAM17,LITAF,LEP,DAPK2,FGF2,DUSP6,LGALS9,PPIA,CD74,FAS,S100A7,HLA-G,JUN,EDN1,PTPRJ,THBS1,ANXA1,CCL28,SAA1,TGFB2,KIT,S100A8,STIM1,ADORA1,MAPKAPK2,AMOT,HCAR2,PRNP,CCR1,RPS19,THBS4,VCAM1,FCGR2A,GNA12,ANOS1,MAPK9,ENG,CSF1R,PLXND1,GIT1,APP,GRN,CXCL16,ITGB2,MT-ND1,NTRK3,FCER1G,NCKAP1L	94	
Cardiovascular Disease, Organismal Injury and Abnormalities, Tissue Morphology	size	size of infarct	7.81E-07	 	-0.602	 	-0.099	APOE,LEP,AGER,SESN2,HLA-A,UBQLN1,FGF2,DUSP6,GDF15,ADIPOQ,PPIA,SH3GLB1,C1QA,HIF1A,PANX1,TNFRSF12A,C1QTNF9,HMOX1,ANXA1,ANXA5,SIAH2,TXN,STAT1,MAPKAPK2,UNG,PRNP,MIF,UCP2,HSPH1,EGR1,SOD1,APP,GRN,IL1RN,FCER1G,ESR2,P2RX7	37	
Cellular Function and Maintenance, Hematological System Development and Function	function	function of myeloid cells	8.06E-07	 	1.103	bias	0.407	APOE,PLCB2,SPRED1,MSR1,UNC5B,GDF15,FCER1A,ADIPOQ,PPIA,SMPD1,IRAK1,CXCL10,HLA-G,LGMN,PIK3CG,TGFB2,CYBB,STAT1,CLCN3,NLRC4,CCR1,SIGMAR1,MIF,IL2RG,LCP1,SPP1,UCP2,TYROBP,FCGR2A,NPY1R,EGR1,MAPK9,CAPG,CSF1R,GRN,FOS,ITGB2,TREM2,FCER1G,CNPY3,CD14,PSAP,DUSP4,C3AR1,SIRPA,P2RX7,HSPB1	47	
Cell Signaling, Small Molecule Biochemistry	synthesis	synthesis of nitric oxide	8.12E-07	 	-0.766	 	-2.444	SOCS3,TRAF3,PFN1,ASS1,PIK3R1,SNTA1,CTSG,CD28,HSPA4,DYNLL1,STC2,PIK3CG,ABCC1,CPM,CYBB,AIF1,TP53,PTX3,MIF,SPP1,KLF4,TXNRD1,IL1RN,SLC7A2,CD14,INSR,SIRPA,RPSA,DDAH2,APOE,LEP,ADIPOQ,HYOU1,SLC7A1,SMPD1,C1QTNF9,HLA-G,HMOX1,JUN,EDN1,PARK7,STAT1,ADORA1,S100A1,UCP2,NQO1,G6PD,MAPK9,SOD1,APP,ITGB2,CALM1 (includes others),TSPO	53	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive organ tumor	digestive organ tumor	8.31E-07	 	0.233	 	0.954	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,DEFB132,VIT,DCAF12,RNPEPL1,RBM38,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,PIM3,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,TMEM123,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,RPL37,CYP4F11,AKR1C3,EML4,INTS1,LHFPL2,HSF4,STC2,TUBA1C,MTMR2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,VAT1,TXNDC12,FECH,SLC25A5,EFEMP2,MAP4K4,RPLP0,SNTA1,ITGA8,HLA-DQB1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,NINJ1,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,SIGLEC1,NAP1L4,CD209,RRP1B,ANKRD9,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,DPP3,TMEM230,COMT,CHST11,NMNAT2,GOT1,TMEM53,TBC1D10C,C5orf15,ACP2,ANKMY2,FAM45A,RPL12,ATP10A,GALNT13,SLC39A3,TARS,PREX1,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,SZRD1,KIFAP3,ANO2,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,SUSD1,ODC1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,PLEKHO2,SPTB,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,DPT,PLD3,MTSS1,ICT1,LHPP,KLHL25,PAQR3,MAD2L2,CARMIL1,RUNDC3B,ZNF69,TRAPPC1,PXDC1,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,MRNIP,TMEM41B,ATXN7L3,MRPL17,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,ESR2,DEAF1,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,FBXO10,SFXN4,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,FUCA2,GNA12,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,BTF3L4,BMPER,SIM1,PPIL1,HAGH,ADRA1A,BZW2,NCDN,MEGF9,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,PFKFB3,IL2RG,RILPL1,TNPO1,SDHC,UBA6,ARSA,MT-ND4L,GYS2,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TMEM176B,TFPT,CALHM2,PTGFR,ERAP2,SLC1A4,DENND4B,MECR,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,ZNF511,SLC12A2,ST3GAL6,NMT2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,PIP5K1C,YARS,IL10RA,ALDOA,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,CDK16,CTNNA1,ACSF2,PFKL,DCLK2,IGHG3,SRGAP1,CCL28,HLA-DRA,NACC1,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,COL5A3,UQCR10,PIGK,PRMT5,P2RY12,RUFY3,MAPRE3,MVD,GAB2,DYNLT1,CYBB,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,GPS2,ANLN,PSMC4,UQCR11,MARS,UBE2D2,MPP3,IL1RN,HSPA13,ACOT4,AKR1B1,UBE2J2,SPX,LEP,STMN2,CD2,NLGN1,PRDX5,PDGFA,ERN1,FAM47E,GANAB,RRP36,RAMP2,SLFN5,FLNA,SENP3,CCDC73,SLC40A1,S100A8,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,ATP6V1B2,SHMT2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,YWHAG,SURF1,IRF5,CTSB,C15orf39,PLTP,FTH1,EPHX1,CD163L1,EVA1B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,SLC25A1,ENG,MAGEC3,CSTB,MYO5A,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,CREG1,FYB,TXNRD1,SLC7A2,TNS1,HSPB1,IGFBP4,F2RL3,DNASE1L3,PLGRKT,BARD1,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,STAT1,MT-CO1,THBS4,PREB,TRIM55,IPO4,G6PD,TSN,APOLD1,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,GSS,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,BTG3,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,ZFAND2B,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,GLIS2,SLC48A1,RHBDD2,BRINP2,TREM2,USP22,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,RILP,HIST1H4H,RET,DHX32,MDH2,BCKDK,C7orf50,MFSD3,HK1,SHOC2,FUCA1,PRKRA,TRIOBP,PACSIN3,GSDMB,XYLT1,TALDO1,HSPA9,RAC1,CPVL,GPAA1,RASD1,C9orf16,EVI2B,SH2B3,MAPT,TMEM176A,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,ARL2,SPIRE1,SRM,COPS4,SPRED1,SDHB,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,RRAGD,OAZ1,SOX18,KCTD1,MAPKAPK2,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,OAF,VSIG4,KCNJ3,MRPS16,PLXND1,KIAA1683,PLBD2,TMEM2,APOC1,EPHB3,SLC1A2,GBE1,PDE8B,C6,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,UNG,TP53,ATP5J,LCP1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TMEM201,PPTC7,FGFR2,TIMM8B,FLOT1,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,UCK1,MARCH4,TULP3,TMEM33,LYPLA1,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CKAP4,ZNF827,CD74,SLC35B2,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,TTC23,FCGR3A/FCGR3B,G3BP2,TMC2,WDR36,SRA1,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,NR4A2,MOBP,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,USP46,TSC22D2,TTYH3,SEMA3C,ABCC3,CSTF3,PTER,ABCB6,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,ZNRF3,RHOG,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,CHMP1A,C17orf53,LACTB,TOP3B,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,SLC25A39,CDH20,NDUFA6,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SYCE1,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,STOX1,TOX2,MCRS1,LONP1,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,PWWP2B,NQO1,HPS1,TRPA1,LARP6,NRBF2,GIT1,FGF1,ANGPTL5,SHB,CIDEA,LGALS2,KIF5B,TTL,EIF3I,GZF1,GXYLT2,CADM3,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,TTC1,SLBP,PIP,FANCE,UCHL1,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,PSMD14,STIM1,TPO,TP53RK,AMFR,PI4KA,LETM1,ADRM1,TYROBP,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,ACTR1A,EFR3A,SLC7A11,XPO5,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,SEPHS2,HMOX1,RNF167,PCK2,NDUFC2,KCNMA1,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,CD160,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1171	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	response	response of phagocytes	8.39E-07	Increased	4.546	bias	2.462	GAB2,AGER,ERN1,FCER1A,BIN1,FAS,IRAK1,PTPRC,CXCL10,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,PIK3CG,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,CCR1,EIF2AK1,PTX3,SIGLEC1,MIF,VCAM1,UCP2,TYROBP,FCGR2A,CAPG,CMC2,ISG15,SPON2,APP,ITGB2,TREM2,FCER1G,IL10RA,RARRES3,CD14,IGHA1,SIRPA,P2RX7	44	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	export	export of lipid	8.68E-07	Increased	2.217	bias	0.880	TP53,APOE,SCD,LEP,APOB,AGER,MSR1,SNTB1,GDF15,RAC1,ADIPOQ,CRAT,HRAS,SMPD1,SLC25A1,IRAK1,APP,GIPR,CES1,CTSS,ABCC1,SAA1,APOC1,CD14,S100A8,PLTP,ABCC3,HCAR2,NPC2	29	
Cell Death and Survival	cell death	neuronal cell death	9.14E-07	 	-0.463	 	-0.217	AGER,ITSN1,PIK3R1,VAC14,SH3GLB1,HRAS,CXCL9,PANX1,SLC9A1,SGPL1,LGMN,ATF4,STAM,UNG,TP53,SURF1,MAD2L2,HAX1,NR1D1,STIP1,BTG2,CTSB,GAPDH,AARS,ESR2,APOE,DDIT3,UBQLN1,FGF2,DUSP6,GDF15,HYOU1,SLC1A3,FKBP1A,UCHL1,JUN,GBA,UBE2K,ADORA1,NFE2L2,GJB2,MBOAT7,SIGMAR1,UCP2,EGR1,MT-ND4,TRIB3,CPEB4,APP,FOS,NR4A2,NTRK3,PPT1,PEA15,CYCS,GAB2,CD4,MBP,UNC5B,MAP1B,NRN1,HSPA5,CTSD,PACS2,CYBB,GCLM,RET,LANCL1,BCKDK,STXBP1,MIF,RAC1,CITED1,RASD1,ADAM12,ADCYAP1R1,IL1RN,MAPT,MAPK10,NAGLU,CLCN7,INSR,HSPB1,SDHB,LEP,VAPA,HIF1A,FAS,HDGF,CIAPIN1,HMOX1,PARK7,PPP1R9B,KCNMA1,THBS1,TGFB2,NSMF,STAT1,FAM162A,ATP13A2,PRNP,SCN2A,HSPH1,NQO1,G6PD,MAPK9,SOD1,KIFAP3,FGF1,SERPINE2,CAPNS1,SLC1A2,P2RX7	113	
Cellular Function and Maintenance	function	function of blood cells	9.17E-07	 	-0.091	bias	-0.989	PIK3R1,HLA-DQB1,PANX1,CXCL10,PTPRC,CHST2,BCAT1,LGMN,CTSS,PIK3CG,ABCC1,TP53,LCP1,FLOT1,IRF5,NINJ1,ARHGDIB,IL10RA,DUSP4,TCF7,C3AR1,BANK1,APOE,GADD45B,HLA-A,PSMB10,GDF15,ADIPOQ,PPIA,LGALS9,CD74,PTPRJ,NFE2L2,CCR1,CD209,SIGMAR1,PLXNA1,UCP2,FCGR2A,TYROBP,EGR1,TRIB3,GRN,ITGB2,FOS,TREM2,MS4A2,FCER1G,PSAP,P2RY12,ARHGDIA,ABCB6,GAB2,TRAF3,PLCB2,CD4,CMA1,UNC5B,TLR8,FCER1A,CEBPG,CD28,RHOG,IFI30,CYBB,CLCN3,NSMAF,TBC1D10C,EIF2AK1,IL2RG,MIF,SPP1,RAC1,CAPG,FYB,PKN1,EFS,CNPY3,CD14,EIF5A,SIRPA,HSPB1,SPRED1,LEP,MSR1,SMPD1,IRAK1,HLA-G,FLNA,TGFB2,KIT,STAT1,NLRC4,NPY1R,MAPK9,VSIG4,IL20RB,CSF1R,P2RX7	99	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by granulocytes	9.36E-07	 	-0.403	 	-1.343	APOE,SOCS3,PLCB2,ADAM17,CRYAB,MSR1,CD2,CMA1,PIK3R1,UNC5B,CTSG,ADIPOQ,PPIA,HIF1A,IL17RA,FAS,CXCL10,HMOX1,RSPO3,TIMP1,ANXA1,PIK3CG,STIM1,CFH,MAPKAPK2,NFE2L2,GJB2,TP53,CCR1,PTX3,SPP1,NQO1,ALOX5AP,ITGB2,PREX1,IL1RN,FCER1G,NR4A1,CTSB,CD14,SFRP1,PLTP,C3AR1,HSPB1	44	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of tumor cells	9.71E-07	Increased	2.442	 	1.161	ICMT,SOCS3,TGFBR1,HRAS,DIRAS1,MKI67,HSPA5,UBA2,ODC1,PEG10,SAE1,PLCE1,CCND3,CTSS,PIK3CG,HOXA7,GPC1,RET,TP53,PFKFB3,MIF,RHEB,SPP1,LAIR1,PCSK6,RAC1,BAMBI,ANXA2,SLC3A2,ADCYAP1R1,IL1RN,BTG2,CTSB,INSR,SFRP1,SQSTM1,CYR61,CST6,AKR1B1,ESR2,CD151,PIM3,LITAF,FHL1,LEP,DDIT3,FGF2,GDF15,ADIPOQ,HIF1A,RPS4X,TAX1BP3,FAS,NELFE,HDGF,S100A7,UCHL1,HMOX1,JUN,PARK7,EDN1,TIMP1,THBS1,ANXA1,TGFB2,KIT,RHOBTB2,MCRS1,STAT1,ACVR1C,NDUFAF3,COX17,CD160,EGR1,LZTS2,CSF1R,FGF1,GRN,FOS,NR4A2,NR4A1,EFEMP2	82	
Cell Morphology	morphology	morphology of cells	1.01E-06	 	 	 	 	CRYAB,AGER,PIK3R1,COL8A1,C1QA,ODC1,PTPRC,IP6K3,CCND3,GLB1,SPTB,ATF4,ARHGEF26,PLXNB2,AIF1,MGAT1,MRPL24,LAMTOR4,TP53,CERS6,RBM38,LCP1,RHEB,DPT,YWHAG,MTSS1,SURF1,MAD2L2,FGFR2,TPM3,ANXA2,HAX1,TMEM127,CTSA,NPR3,CTSB,ESR2,STEAP3,APOE,PIM3,SLC4A2,FGF2,GDF15,HLA-DQA1,ADIPOQ,HEXA,COL15A1,SYNM,OGT,PTPRJ,SORBS1,TNXB,PLIN2,AMOT,NFE2L2,CCR1,S100A1,IGKC,GNA12,DGAT2,SNCG,CSTB,CPEB4,GRN,MYO5A,FOS,ATP6V1F,NTRK3,FLNC,PPT1,MAZ,NR4A1,TPP1,PSAP,ARHGDIA,SOX9,DCX,ADRA1A,SOCS3,SEPT9,ABCA3,MBP,NRN1,TYMP,BIN1,PNRC2,CERS2,CD28,CTSD,HSPA4,HSF4,RHOG,ENTPD5,CXCL14,HOXA10,HOXA7,CNTNAP1,GCLM,IL2RG,PTPRQ,GM2A,MAPK8IP2,HNRNPAB,DMTN,ARSA,KLF4,MLST8,SPINK5,ADAM12,NAGLU,CAPN2,PIK3AP1,INSR,TNS1,TMEM176B,SIRPA,RPSA,ETV5,CD151,PEBP1,PTGFR,ATP6V0C,IGFBP4,MSR1,FAT3,DMD,CIAPIN1,HLA-G,EDN1,CFH,MCRS1,STAT1,ATP13A2,KRT14,VCAM1,CAPZB,TRIM55,SLC9A3R1,NPY1R,SLC12A2,TUBG1,DVL1,ST3GAL6,EMD,SOD1,CISD2,GIT1,KIF3B,AIFM2,FGF1,SERPINE2,APLP2,KIF5B,PLIN1,ITSN1,TOR1A,ITGA8,SNTA1,RAN,HRAS,SH3GLB1,HLA-DQB1,CXCL10,PEG10,LGMN,ABR,GAA,PIK3CG,ZBTB16,EYA2,WNT5B,CFL1,CSRP2,COMMD9,CPA3,TSPAN33,HMGA1,SYTL1,SERINC2,CCND2,CD68,RTN4,SFRP1,B3GNT5,ITGA7,C3AR1,LCP2,ADAM17,TCEA1,PSMB10,HLA-A,CDK16,SLC1A3,H2AFZ,ATP6AP1,CES1,JUN,GBA,LAMP1,STIM1,ACVR1C,PLOD3,CALML3,NDUFS4,MBOAT7,KRT6B,TYROBP,EGR1,SLIRP,POMGNT1,APP,ITGB2,FIS1,LAMP2,SREBF2,SBF1,FCER1G,PEA15,CBX4,NCAM1,GAB2,PFN1,ARF1,CD4,MAP1B,LHCGR,SDC4,TAF10,CHST15,CAMK2D,CFL2,CYBB,ANXA7,RILP,RET,CLCN3,EIF2AK1,MIF,SPP1,ACP2,LMO4,SGCG,TALDO1,RAC1,SIPA1L1,IL1RN,SH2B3,MAPT,FMN2,RARRES3,CLCN7,LFNG,JTB,PAFAH1B2,LEP,EPB41L3,ERN1,SLC7A1,SMPD1,FAS,PPP1R9B,THBS1,FLNA,KCNMA1,ANXA1,TGFB2,ARHGEF2,MAPKAPK2,ALPL,CTDNEP1,RAB8B,PRNP,COL5A2,AP3D1,MTMR14,MAPK9,SLC5A3,CSF1R,KIF2A,CLDN1,APOC1,EPHB3,PDE8B,NCKAP1L,P2RX7,ATP6V1B2	286	
Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis	1.02E-06	Increased	4.816	bias	1.998	GAB2,PFN1,AGER,CD4,SH3GLB1,C1QA,BIN1,CLIP1,CXCL10,PTPRC,RHOG,ABR,MCOLN3,ITGAV,CYBB,CLCN3,GULP1,TP53,EIF2AK1,PTX3,MIF,RAC1,CAPG,OSTM1,HSPA8,PIP5K1C,CD14,SIRPA,LEP,MSR1,ADIPOQ,SMPD1,FAS,HMOX1,PTPRJ,KCNMA1,THBS1,ANXA1,SAA1,ANXA5,TUB,STIM1,ADORA1,MAPKAPK2,FCGR3A/FCGR3B,SIGLEC1,UCP2,FCGR2A,RAB7A,APP,ISG15,MYO5A,ITGB2,LAMP2,TREM2,FCER1G,P2RX7	57	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	efflux	efflux of lipid	1.08E-06	Increased	2.067	bias	0.865	TP53,APOE,SCD,LEP,APOB,AGER,MSR1,SNTB1,GDF15,RAC1,ADIPOQ,HRAS,SMPD1,SLC25A1,IRAK1,APP,GIPR,CES1,CTSS,ABCC1,SAA1,APOC1,CD14,S100A8,PLTP,ABCC3,HCAR2,NPC2	28	
Cellular Function and Maintenance	engulfment	engulfment of antigen presenting cells	1.10E-06	Increased	4.132	bias	2.104	GAB2,AGER,MSR1,HYOU1,SMPD1,BIN1,FAS,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,MAPKAPK2,EIF2AK1,PTX3,CD209,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	30	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	microtubule dynamics	1.15E-06	Increased	3.703	bias	-0.020	CRYAB,TGFBR1,ITSN1,AGER,PIK3R1,TOR1A,ITGA8,RAN,HRAS,C1QA,KPNA1,SLC9A1,CLIP1,MIEN1,CXCL10,DYNLL1,GLB1,AJUBA,CTSS,ABCC1,KIF21A,PLXNB2,KIF5C,TESK1,TP53,LCP1,RIMS3,CFL1,MTSS1,CARMIL1,FGFR2,TPM3,FLOT1,CKAP2,NINJ1,PIP5K1C,STIP1,BTG2,RTN4,GAPDH,CYR61,ACTG1,LCP2,APOE,RAP2A,NME1,FGF2,BTG3,CDK16,GDF15,TSGA10,ADIPOQ,CKAP4,SDC3,ENAH,UCHL1,DCLK2,SHTN1,JUN,SRGAP1,SNX10,ACAP2,TUB,NPTXR,CALML3,S100A1,WDR36,PTPRK,EGR1,GNA12,ENG,CPEB4,APP,GRN,MYO5A,FOS,MYOC,NTRK3,TENM4,ADCY1,FKBP4,P2RY12,GABARAP,DCX,RUFY3,MAPRE3,NCAM1,PRKACB,PFN1,NCDN,YWHAH,SEPT9,ATP2B1,EML4,MBP,MAP1B,UNC5B,FCER1A,NRN1,SDC4,DYNLT1,TUBB,NNMT,RHOG,COMT,HOXA7,NEO1,CDC42EP1,CNTNAP1,C1QBP,RET,BMP2K,PTPRQ,MAPK8IP2,RAB10,RAC1,RIMS4,CAPG,UBA6,ARSA,SIPA1L1,TXNRD1,LMCD1,METRN,PREX1,MAPT,MAPK10,RARRES3,CAPN2,INSR,SIRPA,UBE2I,HSPB1,ARL2,RNF165,LEP,CD2,STMN2,EPB41L3,NLGN1,PDGFA,ERN1,FLRT1,VAPA,PKM,SMPD1,HNRNPK,FAS,PHLDB2,TNFRSF12A,HDGF,PPP1R9B,THBS1,FLNA,LOC102724428/SIK1,KIT,ARHGEF2,KLHL42,NSMF,MAPKAPK2,PRNP,THBS4,MT-ND6,CAPZB,SLC9A3R1,TUBG1,DVL1,NQO1,F13A1,MAPK9,SOD1,CSF1R,KIF3B,GIT1,PLXND1,FGF1,KIF2A,KIFC3,CAPNS1,KIF5B,TTL,EPHB3,TBC1D7,RTN3,P2RX7	185	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Hematological System Development and Function, Inflammatory Response	phagocytosis	phagocytosis of myeloid cells	1.17E-06	Increased	4.013	bias	1.809	GAB2,AGER,BIN1,FAS,CXCL10,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	31	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast or ovarian cancer	breast or ovarian cancer	1.17E-06	 	0.252	 	0.093	TGFBR1,AGER,PCLO,C1QTNF5,PIK3R1,VAC14,NPAS2,BTBD11,POR,EIF3B,CCND3,AJUBA,ARHGEF26,AIF1,FBL,SRPRA,ALCAM,NHLH1,ACTG1,EPHX1,FTH1,BANK1,GADD45B,SNX17,COL15A1,SYNM,RABL6,TUBB4B,ENG,AFF3,KIF7,MAZ,WBP2,NR4A1,SOX9,AKR1C3,SEPT9,YWHAH,FCER1A,AP1B1,CTSD,CCT5,TUBA1C,ADAMTS5,FYB,DYNLRB1,TXNRD1,PIK3R3,CCDC43,RBX1,KCTD19,INSR,CBX3,HSPB1,IGFBP4,PLGRKT,BARD1,FAT3,COL6A6,PHLDB2,HLA-G,ALDH2,EDN1,IGSF8,CFH,STAT1,MT-CO1,AKR1C1/AKR1C2,SOD1,DHX8,CXXC5,SLC25A5,TUBA1B,CPAMD8,THEMIS2,SRP19,MKI67,DDX20,GLO1,EEF1D,MIEN1,MPV17L2,MGAT4B,CAPN6,HMGA1,FARSA,ACAD11,DPH2,C19orf53,SNRNP25,RTN4,ARHGAP35,KRTAP4-4,GSTP1,HLA-A,FKBP1A,H2AFZ,ENAH,CES1,JUN,MT-CYB,TRIM16,DIP2B,TUB,NPTXR,FKBP5,LIMCH1,GJB2,RPS24,NAP1L4,SIGLEC1,PLXNA1,KRT6B,EGR1,SLIRP,COPS3,PLA2G2A,CALM1 (includes others),NCAM1,PFN1,CD4,LHCGR,GSPT1,CNDP2,SLC25A6,DPP3,COMT,RPL19,PGP,C1QBP,RET,TBC1D10C,HK1,GSDMB,LAGE3,PREX1,FMN2,CYP4A11,ATF5,PCDH19,SSU72,THBS1,MAPKAPK2,MLH3,PSMB4,SCN2A,TPST2,GUK1,KIAA1683,THRSP,EPHB3,C6,HLTF,PPP2R1B,CRYAB,WHSC1,IGSF6,COL8A1,KCMF1,CXCL9,CLIP1,ODC1,FADS3,IP6K3,ARID3B,FRAS1,KEAP1,ATF4,MYBBP1A,MRPL24,TP53,UXS1,PROSC,PPP1R1B,KCTD16,TNFRSF10B,TPM3,FLOT1,FGFR2,BRF2,HAX1,ARHGDIB,NRBP1,TMEM127,CTSA,SCUBE1,BTG2,GAPDH,DUSP4,LYPLA1,ESR2,STEAP3,APOE,NME1,NACC2,FBXO10,CDH18,FGF2,CUBN,GDF15,HSPB8,ATRAID,COL16A1,SHTN1,PTPRJ,TNXB,SORBS1,PLIN2,ATP5J2,DAB2,FAM96B,ADORA1,HCAR2,NFE2L2,TMC2,RPL4,FUCA2,GNA12,SLC39A6,TRIB3,C1orf122,HSPA2,CPEB4,FOS,MT-ND1,NR4A2,NTRK3,KRT6A,ARHGDIA,SEMA3C,ABCC3,HAGH,ABCA3,NME2,TYMP,CES2,STARD7,KRTAP4-6,CYP3A5,CXCL14,STAB1,CDC42EP1,MUCL1,TOP3B,PFKFB3,IL2RG,GM2A,TNPO1,PCSK6,MT-TE,KLF4,DMXL2,FOSB,TLN2,ADAM12,UHRF1BP1L,MEGF8,TMEM176B,TFPT,ERAP2,MSR1,MECR,DMD,RAP1GDS1,TIMP1,LOC102724428/SIK1,RHOBTB2,MCRS1,LONP1,KRT14,PSAT1,VCAM1,SLC9A3R1,NPY1R,TUBG1,NQO1,HPS1,EMD,TRPA1,LARP6,PDLIM4,S100A2,ATIC,NFE2L1,FGF1,SHB,CXCL16,CLGN,LGALS2,APOB,ITSN1,HRAS,KPNA1,CXCL10,CECR1,BCAT1,FAM91A1,ABR,ABCC1,PIK3CG,EYA2,WNT5B,TUBB2A,AASS,PDE1C,CCND2,CD68,MS4A4A,MS4A7,GLUL,ALDOA,SFRP1,AIDA,TCF7,CYR61,MYEOV,HIST1H1C,ADAM17,LAPTM5,UBQLN1,CDK16,XPOT,TTC1,PFKL,TAX1BP3,PIP,FANCE,RPL35,GBA,TOP2A,TPO,PLOD3,RPS19,ADRM1,LETM1,TBC1D9,MT-ND4,KRT5,ATXN2L,EIF3G,FIS1,COL5A3,SREBF2,MS4A2,PEA15,CYCS,CBX4,DVL3,MAPRE3,HOXB5,GAB2,MT-TT,XPO5,UTP4,TUBB,UBA2,MTCH2,ITGAV,IFI30,KPNA2,SIAH2,TENM2,EIF2AK1,MIF,SPP1,BMP2K,ANLN,PSMC4,MARS,PKN1,ADCYAP1R1,MAPK10,AKR1B1,LEP,EPB41L3,PDGFA,PRDX5,CUTA,PKM,SLC7A1,HIF1A,PLPP1,FAS,HMOX1,SLFN5,PCK2,FLNA,NDUFC2,ANXA1,VCP,TGFB2,HIST2H2AC,KIT,SLC40A1,CCDC73,S100A8,ARHGEF2,HMGCS1,STK40,ALPL,NACA,NDUFAF3,ADCY2,TAF6,QSOX1,SLC5A3,CSF1R,ENO1,TRPM6,MT-ND5,CLDN1,UBA1,RTN3,ATP6V1B2,SHMT2	415	
Post-Translational Modification, Protein Degradation	oxidation	oxidation of protein	1.17E-06	 	-1.303	 	-0.557	APOE,HSPA4,HMOX1,FTL,PARK7,CYBB,RAC1,TXN,NFE2L2,FTH1,APP	11	
Cellular Movement	chemotaxis	chemotaxis of cells	1.23E-06	Increased	5.118	bias	1.184	SOCS3,TGFBR1,PFN1,AGER,CD4,CTSG,HRAS,CXCL9,GNB1,PTPRC,CXCL10,CD28,RHOG,ABCC1,PIK3CG,CXCL14,ITGAV,CYBB,HOXA7,TXN,C1QBP,AIF1,TMSB10/TMSB4X,CLCN3,LCP1,MIF,SPP1,RAC1,FLOT1,CAPG,ANXA2,NINJ1,TPSAB1/TPSB2,PREX1,ACKR3,YARS,PIP5K1C,RTN4,CAPN2,CYR61,ELMO2,C3AR1,SIRPA,CD151,APOE,ADAM17,LITAF,LEP,DAPK2,FGF2,DUSP6,LGALS9,PPIA,CD74,FAS,S100A7,HLA-G,JUN,EDN1,PTPRJ,THBS1,ANXA1,CCL28,SAA1,TGFB2,KIT,S100A8,STIM1,ADORA1,MAPKAPK2,HCAR2,PRNP,CCR1,RPS19,THBS4,VCAM1,FCGR2A,GNA12,MAPK9,ENG,PLXND1,GIT1,CSF1R,APP,GRN,CXCL16,ITGB2,MT-ND1,NTRK3,FCER1G,NCKAP1L	91	
DNA Replication, Recombination, and Repair	degradation	degradation of DNA	1.25E-06	 	0.954	 	0.572	APOE,CRYAB,LEP,DDIT3,MSR1,CD2,UBQLN1,DNASE1L3,PAM16,PIK3R1,BARD1,CTSG,ADIPOQ,PPIA,HRAS,BIN1,FAS,CD28,JUN,KEAP1,TOP2A,TGFB2,NACC1,STAT1,PRNP,TP53,CD53,RAC1,MAPK9,SOD1,TPSAB1/TPSB2,APP,GRN,ENO1,MAPT,PPT1,RTN4,CAPN2,HSPB1	39	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking	adhesion	adhesion of immune cells	1.25E-06	Increased	3.518	bias	0.883	GAB2,PER1,AGER,CD4,CTSG,HRAS,C1QA,SLC35C1,CXCL9,PANX1,CXCL10,PTPRC,CD28,PIK3CG,CYBB,STAB1,TXN,TP53,LCP1,MIF,SPP1,RAC1,FYB,NINJ1,SPON2,PREX1,PIP5K1C,CD14,ALCAM,PLTP,ITGA7,SIRPA,LCP2,CD151,RAP2A,APOE,ADAM17,MSR1,CD2,GDF15,ADIPOQ,LGALS9,CD83,HIF1A,CD74,FAS,THBS1,ANXA1,CCL28,ANXA5,KIT,S100A8,STAT1,ADORA1,FCGR3A/FCGR3B,CCR1,CD209,VCAM1,FCGR2A,DNAJC1,APP,ITGB2,BMPER,P2RX7	64	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of phagocytes	1.29E-06	Increased	3.456	bias	0.811	PLCB2,AGER,PIK3R1,CTSG,CXCL9,CXCL10,NARS,CTSS,PIK3CG,ABCC1,ITGAV,CYBB,STAB1,TXN,MIF,SPP1,RAC1,ANXA2,NINJ1,PREX1,IL1RN,MS4A4A,SH2B3,RTN4,IL10RA,ALCAM,SIRPA,APOE,ADAM17,ADIPOQ,CD74,HIF1A,IL17RA,FAS,FLNA,TIMP1,SAA1,ANXA1,KIT,S100A8,MAPKAPK2,NLRC4,PRNP,CCR1,CD209,VCAM1,TYROBP,ENG,PLXND1,CSF1R,APP,ITGB2,TREM2	53	
Organismal Injury and Abnormalities	growth	growth of lesion	1.30E-06	Increased	3.900	 	2.278	TGFBR1,AGER,HRAS,MKI67,CXCL9,ODC1,PEG10,CCND3,CTSS,ABCC1,PIK3CG,TXN,TP53,CERS6,RHEB,LAIR1,PAQR3,TNFRSF10B,FGFR2,ANXA2,HMGA1,HSPA8,BTG2,CTSB,GAPDH,ALCAM,SFRP1,SQSTM1,CYR61,ESR2,FTH1,APOE,NME1,FHL1,PIM3,DDIT3,BTG3,FGF2,GDF15,ADIPOQ,HYOU1,TAX1BP3,S100A7,UCHL1,OGT,JUN,HCAR2,ACVR1C,FCGR3A/FCGR3B,CCR1,EGR1,SLC39A6,LZTS2,ENG,SNCG,GRN,FOS,NR4A2,FCER1G,NR4A1,SOX9,ICMT,SOCS3,SLC7A11,SEPT9,DIRAS1,HSPA5,UBA2,HSPA4,PGD,PLCE1,SAE1,CXCL14,CYBB,HOXA7,SIAH2,GPC1,RET,PFKFB3,MIF,SPP1,PCSK6,RAC1,BAMBI,SLC3A2,ADCYAP1R1,IL1RN,ACKR3,CAPN2,INSR,CST6,AKR1B1,CD151,LITAF,LEP,PKM,HIF1A,RPS4X,FAS,NELFE,HDGF,RAP1GDS1,HLA-G,HMOX1,PARK7,EDN1,TIMP1,FLNA,THBS1,ANXA1,TGFB2,KIT,RHOBTB2,CYGB,CHCHD4,MCRS1,STAT1,NDUFAF3,PSMB4,COX17,CD160,HSPH1,MAPK9,CISD2,CSF1R,NDUFA13,FGF1,CXCL16,CISD1,CAPNS1,EFEMP2	131	
Molecular Transport	quantity	quantity of metal ion	1.45E-06	Increased	2.781	bias	0.198	PLCB2,ATP2B1,PIK3R1,FCER1A,HRAS,CXCL9,HSPA5,PANX1,SLC9A1,GNB1,CXCL10,PTPRC,CD28,CAMK2D,PLCE1,CPM,MCOLN3,PIK3CG,CYBB,C1QBP,TP53,SPP1,LAIR1,STK39,PPP1R1B,ANXA2,TPSAB1/TPSB2,ADCYAP1R1,MAPT,INSR,VDAC1,AKR1B1,C3AR1,LCP2,BANK1,PTGFR,APOE,LEP,F2RL3,CD2,FGF2,HYOU1,PPIA,FKBP1A,SMPD1,FAS,LYZ,EDN1,PPP1R9B,PTPRJ,SAA1,S100A8,STIM1,SCNN1B,ADORA1,FCGR3A/FCGR3B,PRNP,CCR1,S100A1,SIGMAR1,VCAM1,SLC9A3R1,FCGR2A,IGKC,SLC12A2,DVL1,TRPA1,SOD1,FGF1,APP,FOS,SHB,FCER1G,MS4A2,P2RX7,ADRA1A,NCAM1	77	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease, Skeletal and Muscular Disorders	uterine leiomyoma	uterine leiomyoma	1.48E-06	 	 	 	 	SOCS3,AHCYL1,RPE,MEGF9,MAF,LHCGR,RAB9A,MT-CO2,CXCL14,RPL19,WNT5B,SLC2A5,CAPN6,PSMA6,PLD3,DPT,SLC24A3,AP2S1,PIK3R3,KCNG1,ADAM12,ALDOA,SFRP1,CYR61,ESR2,RORB,FTH1,PHLDA2,FGF2,SLC7A1,RAMP2,PLPP1,FAS,JUN,VCP,CFH,PI4KA,RPS19,DLGAP4,DVL1,SLC5A3,STXBP6,FOS,RPS15,NR4A2,PCCA,NR4A1,NR5A2,DCX,ADRA1A	50	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	cellular infiltration by macrophages	1.48E-06	 	-0.267	 	-1.284	APOE,ADAM17,LEP,AGER,ADIPOQ,HRAS,HIF1A,IL17RA,CXCL10,HMOX1,CES1,GBA,EDN1,ANXA1,DUSP10,PIK3CG,SAA1,CYBB,NFE2L2,TP53,CCR1,PTX3,MIF,SPP1,NQO1,CSF1R,NINJ1,APP,ITGB2,GLIS2,IL1RN,PLTP,C6,CYR61,P2RX7	35	
Cellular Movement	homing	homing of cells	1.64E-06	Increased	5.203	bias	1.138	SOCS3,PFN1,TGFBR1,AGER,CD4,CTSG,HRAS,TYMP,CXCL9,CHST2,CXCL10,PTPRC,GNB1,CD28,RHOG,ABCC1,PIK3CG,CXCL14,ITGAV,CYBB,HOXA7,AIF1,TXN,C1QBP,CLCN3,TMSB10/TMSB4X,MIF,LCP1,SPP1,RAC1,FLOT1,CAPG,ANXA2,FYB,TPSAB1/TPSB2,NINJ1,PREX1,ACKR3,PIP5K1C,YARS,RTN4,CAPN2,CYR61,ELMO2,C3AR1,SIRPA,CD151,APOE,ADAM17,LITAF,LEP,DAPK2,FGF2,DUSP6,LGALS9,PPIA,CD74,FAS,S100A7,HLA-G,JUN,PTPRJ,EDN1,THBS1,CCL28,SAA1,ANXA1,TGFB2,KIT,STIM1,S100A8,ADORA1,MAPKAPK2,AMOT,HCAR2,PRNP,CCR1,RPS19,THBS4,VCAM1,FCGR2A,GNA12,NQO1,ANOS1,MAPK9,ENG,GIT1,PLXND1,CSF1R,APP,GRN,ITGB2,CXCL16,MT-ND1,NTRK3,FCER1G,NCKAP1L	97	
Cancer, Organismal Injury and Abnormalities	malignant solid tumor	advanced malignant solid tumor	1.65E-06	 	0.420	 	-0.022	TGFBR1,SLC7A11,AKR1C3,LHCGR,CSNK1A1,HRAS,NRN1,RNASE1,CXCL9,TUBB,POR,PTPRC,CYP3A5,PIK3CG,HOXA10,IFI30,TUBA1C,TMSB10/TMSB4X,CLCN3,RET,TP53,PTX3,IL2RG,SPP1,TNFRSF10B,TUBB2A,FGFR2,CAPG,KLF4,DYNLRB1,HAX1,EFS,CCND2,ACKR3,IL1RN,GLUL,DUSP4,INSR,SFRP1,HTRA1,TMEM176B,ESR2,STEAP3,GSTP1,SCD,ERAP2,IGFBP4,S100A11,MSC,TCEA1,EPB41L3,STMN2,FGF2,SRD5A1,PDGFA,DUSP6,GDF15,PPIA,FKBP1A,DMD,HIF1A,PLPP1,COL15A1,FAS,HMOX1,EDN1,KCNMA1,FLNA,THBS1,TOP2A,TGFB2,DAB2,RNH1,KIT,LOC102724428/SIK1,CFH,STAT1,ALPL,FCGR3A/FCGR3B,MYL12A,PRNP,NDUFB4,VCAM1,AKR1C1/AKR1C2,FCGR2A,TUBB4B,EPB41L4B,TUBG1,CSF1R,SLC5A3,ATIC,FGF1,FTL,CLGN,LGALS2,CXXC5,P2RY12,SEMA3C,ABCC3,NCAM1	100	
Tissue Morphology	quantity	quantity of cells	1.83E-06	Increased	3.881	bias	0.250	TGFBR1,AGER,PCLO,PIK3R1,C1QA,SLC35C1,PANX1,PTPRC,IP6K3,CCND3,GLB1,ST6GALNAC2,SPTB,ATF4,STAM,LMX1A,TP53,RBM38,LAIR1,MAD2L2,FGFR2,ARHGDIB,HAX1,MYL9,NPR3,CTSB,ALCAM,SQSTM1,NHLH1,ESR2,DEAF1,STEAP3,FTH1,BANK1,RAP2A,APOE,GJB6,PIM3,SLC4A2,GADD45B,DDIT3,FGF2,GDF15,HLA-DQA1,ADIPOQ,HSPB8,PPIA,CD74,PTPRJ,SORBS1,NFE2L2,CCR1,S100A1,FCGR2A,IGKC,GNA12,ENG,SNCG,ISG15,GRN,MYO5A,FOS,NR4A2,NTRK3,RSPO1,FLNC,NR4A1,PSAP,ARHGDIA,SOX9,SIM1,SOCS3,TRAF3,SEPT9,ABCA3,MBP,FCER1A,NRN1,STARD7,CD28,CTSD,CXCL14,HOXA10,STAB1,IL2RG,DMTN,FYB,KLF4,TXNRD1,FOSB,ADAM12,NAGLU,PIK3AP1,INSR,SIRPA,INO80B,HSPB1,CD151,LITAF,MSR1,DMD,IL17RA,PDGFC,IRAK1,HDGF,CIAPIN1,HLA-G,ALDH2,EDN1,TIMP1,SAA1,CFH,STAT1,VCAM1,MT-ND6,CAPZB,NPY1R,SLC12A2,DVL1,NQO1,ST3GAL6,TRPA1,SOD1,GIT1,NFE2L1,FGF1,SERPINE2,CXCL16,CIDEA,APLP2,CAPNS1,LGALS2,SLC14A1,APOB,MAF,HRAS,HLA-DQB1,EEF1D,CHST2,CXCL10,ZBTB7B,SGPL1,DYNLL1,LGMN,CTSS,PIK3CG,MGAT4B,KIF5C,ZBTB16,EYA2,APEX2,WNT5B,TSPAN33,HMGA1,SPON2,SYTL1,MNT,CCND2,IL10RA,B3GNT5,C3AR1,GSTP1,LCP2,ADAM17,RPS3A,PSMB10,HLA-A,DUSP6,CDK16,SLC1A3,CES1,JUN,GBA,CCL28,SLC19A1,TUB,ACVR1C,RPS19,SIGLEC1,TYROBP,EGR1,POMGNT1,APP,PI3,ITGB2,COL5A3,TREM2,FCER1G,P2RY12,NCAM1,GAB2,PER1,CD4,MAP1B,LHCGR,CD63,CAMK2D,PLCE1,COMT,CYBB,NEO1,RET,CLCN3,BCKDK,EIF2AK1,MIF,SPP1,HSPA9,RAC1,PKN1,OSTM1,PREX1,ACKR3,IL1RN,MAPT,SH2B3,MAPK10,RARRES3,CLCN7,LFNG,CYP4A11,PAFAH1B2,SPRED1,LEP,PDGFA,NLGN1,SLC7A1,SMPD1,CD83,HIF1A,FAS,HMOX1,HINT1,PARK7,THBS1,FLNA,ANXA1,DUSP10,TGFB2,KIT,NSMF,S100A8,MAPKAPK2,ALPL,CTDNEP1,PRNP,NACA,RAB7A,VSIG4,MAPK9,F13A1,KIFAP3,IL20RB,CSF1R,ENO1,PAG1,C6,P2RX7,CARM1	259	
Hereditary Disorder, Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders	MELAS syndrome	MELAS syndrome	1.87E-06	 	 	 	 	MT-ND6,MT-ND5,MT-ND1,MT-TQ,MT-ND4,MT-TC,MT-TL1	7	
Cellular Movement	cell movement	cell movement of breast cancer cell lines	1.88E-06	Increased	2.127	bias	0.103	GAB2,TGFBR1,SEPT9,AGER,ARF1,PIK3R1,HRAS,SDC4,CXCL9,CXCL10,PIK3CG,ITGAV,KPNA2,TUBA1C,TP53,SPP1,GSDMB,PCSK6,RAC1,FGFR2,ANXA2,KLF4,ARHGDIB,FOSB,SDCBP,ADAM12,CAPN2,CST6,ESR2,CD151,UBE2I,NME1,LEP,ARPC1B,OSGIN1,FGF2,HIF1A,ENAH,S100A7,JUN,FLNA,TIMP1,ANXA1,NDUFAF3,S100A1,PLXNA1,BHLHE41,MAPK9,SNCG,GIT1,FGF1,MCF2L,FOS,WBP2,MAP4K4	55	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Hematological System Development and Function, Inflammatory Response	phagocytosis	phagocytosis by macrophages	1.98E-06	Increased	3.802	bias	2.042	GAB2,AGER,BIN1,FAS,PTPRC,HMOX1,PTPRJ,THBS1,SAA1,ANXA1,MAPKAPK2,PTX3,EIF2AK1,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,APP,ISG15,ITGB2,TREM2,FCER1G,CD14,SIRPA,P2RX7	26	
Cellular Function and Maintenance	endocytosis	endocytosis	2.21E-06	Increased	4.267	bias	1.184	TGFBR1,RAB5C,C9orf72,ITSN1,ARF1,SCAMP2,MAP1B,HRAS,BIN1,CD63,SNX12,CYBB,STAB1,ADAMTS5,GULP1,EIF2AK1,HSPA9,RAC1,SYP,FLOT1,AP2S1,HAX1,HSPA8,OSTM1,PIP5K1C,MS4A4A,CD14,SIRPA,APOE,ATP6V0C,SNX17,CUBN,HYOU1,FAT3,SMPD1,LDLRAD3,ATP6AP1,HNRNPK,HMOX1,ANXA5,SAA1,DAB2,STIM1,ADORA1,MAPKAPK2,FCGR3A/FCGR3B,CD209,FCGR2A,RAB7A,STON1,RPS21,SNCG,APP,GRN,ATP6V1E1,MYO5A,ITGB2,ATP6V1F,PPT1,APOC1,VAMP8,P2RX7,ATP6V1B2	63	
Molecular Transport	transport	transport of heavy metal	2.29E-06	 	-0.683	 	-0.877	CRYAB,SLC31A1,ARF1,HLA-A,CD4,SLC30A2,HIF1A,FAS,HMOX1,NEO1,SLC40A1,NFE2L2,PRNP,EIF2AK1,AP3D1,SLC39A6,SOD1,SLC39A3,APP,CISD1,FTL,APLP2,MAPT,FKBP4,FECH,COMMD1,BMPER,ATOX1,STEAP3,FTH1	30	
Neurological Disease	neurological signs	neurological signs	2.38E-06	 	-0.885	 	-0.482	CRYAB,AHCYL1,HRAS,GHITM,GNB1,CTSS,HADHB,PNKD,TXN,NAPA,ZBTB16,TP53,FBL,ATP5J,POLR2I,CSRP2,PPP1R1B,TPM3,NGRN,HSPA8,CD68,NR1D1,GAPDH,NDUFB2,APOE,NME1,GJB6,GBP1,DDIT3,FGF2,SRD5A1,SLC1A3,KAZN,PPIA,UCHL1,JUN,TMEFF1,MAL2,GBA,MYL12A,EGR1,SLIRP,PSMB6,APP,MYO5A,FOS,PSME1,LAMP2,NTRK3,PPT1,UQCR10,ADCY1,FKBP4,NR4A1,TSPO,CYCS,SOX9,ADRA1A,PFN1,PFKFB1,ATP2B1,ATP5L,SDC4,DYNLT1,HSPA5,LDHB,AK1,RHOG,GAS5,ATP6V1A,LMCD1,FOSB,MAPT,RARRES3,NDUFS3,ETV5,RPSA,SRM,SCD,COX7B,SDHB,LEP,SLC1A4,PKM,ALAS1,NDUFA2,HMOX1,ALDH2,HINT1,PREPL,KCNMA1,PPP1R2,PRNP,SCN2A,PSAT1,ADCY2,CD160,SOD1,TSN,GIT1,NDUFA13,KCTD13,CAPNS1,SLC14A1,SLC1A2,ATP6V1B2	106	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	immune response	immune response of phagocytes	2.40E-06	Increased	4.041	bias	2.256	GAB2,AGER,ERN1,FCER1A,BIN1,FAS,PTPRC,CXCL10,HMOX1,PTPRJ,THBS1,ANXA1,ANXA5,PIK3CG,SAA1,STIM1,CLCN3,MAPKAPK2,FCGR3A/FCGR3B,TP53,EIF2AK1,PTX3,SIGLEC1,MIF,VCAM1,UCP2,TYROBP,FCGR2A,CAPG,CMC2,APP,ISG15,ITGB2,TREM2,FCER1G,IL10RA,CD14,IGHA1,SIRPA,P2RX7	40	
Cell Death and Survival	cell death	cell death of colorectal cancer cell lines	2.43E-06	 	-1.865	 	-1.733	TRAF3,YWHAH,CSNK1A1,HRAS,CTBP1,G0S2,AHSA1,ITGAV,TMSB10/TMSB4X,NAPA,TP53,MIF,SPP1,PPP1R1B,TNFRSF10B,RAC1,CKAP2,IRF5,TXNRD1,ACKR3,CAPN2,SQSTM1,VDAC1,GSTP1,ADAM17,LEP,DDIT3,BTG3,FGF2,DAPK2,PKM,GDF15,PPIA,DTYMK,GLIPR1,FAS,HMOX1,RABL6,HINT1,EDN1,PARK7,TIMP1,VCP,STAT1,LONP1,NFE2L2,MAPK9,PDLIM4,NR4A2,NTRK3,USP22,CYCS,SOX9	53	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders	Huntington's disease	Huntington's Disease	2.44E-06	 	 	 	 	CRYAB,PFN1,PFKFB1,AHCYL1,ATP2B1,ATP5L,HRAS,GHITM,SDC4,DYNLT1,HSPA5,LDHB,GNB1,AK1,RHOG,CTSS,HADHB,TXN,ZBTB16,NAPA,TP53,POLR2I,FBL,ATP5J,GAS5,PPP1R1B,CSRP2,TPM3,ATP6V1A,LMCD1,NGRN,HSPA8,NR1D1,CD68,GAPDH,RARRES3,NDUFS3,NDUFB2,RPSA,ETV5,SCD,APOE,SRM,NME1,SDHB,GJB6,COX7B,SLC1A4,LEP,DDIT3,GBP1,SRD5A1,FGF2,PKM,SLC1A3,PPIA,KAZN,ALAS1,NDUFA2,UCHL1,ALDH2,HMOX1,HINT1,TMEFF1,JUN,MAL2,PREPL,PPP1R2,MYL12A,PSAT1,SCN2A,ADCY2,CD160,EGR1,SLIRP,PSMB6,TSN,GIT1,NDUFA13,MYO5A,FOS,LAMP2,PSME1,KCTD13,CAPNS1,SLC14A1,UQCR10,NR4A1,FKBP4,TSPO,SLC1A2,CYCS,SOX9,ATP6V1B2,ADRA1A	95	
Cell Death and Survival	cell death	cell death of myeloid cells	2.44E-06	 	0.166	 	-0.028	APOE,ADAM17,LEP,DDIT3,MSR1,RAN,FCER1A,LGALS9,C1QA,HIF1A,PDGFC,FAS,IRAK1,HMOX1,LYZ,ANXA1,CYBB,S100A8,STAT1,HCAR2,NFE2L2,NLRC4,TP53,MIF,NQO1,MAPK9,HAX1,TPSAB1/TPSB2,ISG15,APP,FOS,ITGB2,IL1RN,FCER1G,NR4A1,MS4A2,CTSB,CD14,PIK3AP1,C3AR1,SIRPA,P2RX7	42	
Cell Morphology, Cellular Assembly and Organization	morphology	morphology of lysosome	2.53E-06	 	 	 	 	LAMP2,CTSA,ACP2,KIF5B,GAA,LAMP1,TPP1,NAGLU,ATP13A2,PRNP	10	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of amino acids	2.53E-06	 	1.651	bias	 	LEP,SLC1A4,SLC7A11,FGF2,SLC1A5,SLC1A3,SLC7A1,HRAS,SLC38A1,SLC9A1,CD28,EDN1,ABCC1,SLC19A1,SLC7A5,TP53,STXBP1,SOD1,SLC38A3,SLC3A2,APP,SERINC2,SLC7A10,SLC25A22,SLC7A2,GLUL,SLC1A2,INSR,ABCC3	29	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of antigen presenting cells	2.59E-06	 	0.595	 	-0.453	CCR1,PTX3,APOE,MIF,SPP1,PFN1,TYROBP,FGF2,FGFR2,SOD1,FAS,FGF1,GRN,CD28,HMOX1,TIMP1,ACKR3,THBS1,IL1RN,NR4A1,C6,STAT1	22	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of brain	2.70E-06	 	-0.962	 	-0.962	APOE,FGF2,ADIPOQ,SH3GLB1,CERS2,APP,MAPT,PPT1,LAMP1,CLCN7,ATP13A2,PRNP,NDUFS4	13	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	uptake	uptake of amino acids	2.71E-06	 	0.594	bias	-1.125	TP53,LEP,SLC7A11,SLC1A5,FGF2,SLC1A3,HRAS,SLC7A1,SLC38A3,APP,SLC3A2,SLC7A10,EDN1,SLC7A2,SLC19A1,SLC7A5,GLUL,SLC1A2,INSR	19	
Cell-To-Cell Signaling and Interaction	aggregation	aggregation of cells	2.73E-06	Increased	2.117	bias	0.245	PLCB2,SLC7A11,AGER,CD4,PIK3R1,CTSG,CXCL9,CD63,CXCL10,PTPRC,RHOG,PIK3CG,ITGAV,ANXA7,RET,TP53,PTX3,STXBP1,DMTN,CITED1,SLC3A2,MYL9,PIP5K1C,PLEK,AKR1B1,ACTG1,SIRPA,LCP2,CD151,HSPB1,LEP,CD2,F2RL3,FGF2,GDF15,ADIPOQ,HIF1A,LYZ,CES1,FLNA,THBS1,TIMP1,LAMP1,KIT,DAB2,IGSF8,CFH,AMOT,MYL12A,CD209,VCAM1,FCGR2A,GNA12,SOD1,APP,SERPINE2,ITGB2,FCER1G,P2RY12,NCAM1	60	
Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	fibrosis	fibrosis of liver	2.76E-06	 	-1.223	 	-0.442	SOCS3,APOE,SCD,LEP,AGER,DDIT3,SMPD1,CD74,PDGFC,HDGF,HMOX1,JUN,TIMP1,TGFB2,STAB1,STAT1,NFE2L2,TP53,CCR1,MIF,IL2RG,SPP1,FGFR2,NFE2L1,CTSB,NAGLU,GSTP1,HSPB1	28	
Hereditary Disorder, Organismal Injury and Abnormalities	autosomal dominant disease	autosomal dominant disease	2.88E-06	Decreased	-2.170	bias	 	CRYAB,APOB,C9orf72,C1QTNF5,PIK3R1,RRM2B,SNTA1,MAF,TOR1A,GARS,HRAS,ODC1,GNB1,SGPL1,CCND3,PIK3CG,CHCHD2,KIF5C,TP53,CFL1,CSRP2,TUBB2A,TPM3,FGFR2,DSG1,HAX1,ARHGDIB,CCND2,MBD4,AARS,SQSTM1,ACTG1,DEAF1,ESR2,STEAP3,MT-TL1,FTH1,S100A11,APOE,GJB6,CHCHD10,HSPB8,FKBP1A,SDC3,TAX1BP3,UCHL1,DAB2,TUB,STIM1,RNF135,GJB2,IGKC,KRT5,ENG,APP,GRN,CALM1 (includes others),FTL,FLNC,CYCS,ARHGDIA,SOX9,SIM1,TRAF3,KCND3,TUBB,PLCE1,HSF4,IFI30,RET,IL2RG,ANLN,SDHC,SDCBP,MAPT,SH2B3,PIK3AP1,CLCN7,INSR,CNBP,RPSA,HSPB1,FAT3,HIF1A,PARK7,EDN1,VCP,MT-TS1,KIT,SLC40A1,NSMF,STAT1,ACTN1,PRNP,MT-CO1,SCN2A,THBS4,COL5A2,SLC9A3R1,TUBG1,MTMR14,DVL1,RAB7A,TRPA1,SOD1,CSF1R,KCNQ4,KIF2A,PDE8B	109	
Cancer, Organismal Injury and Abnormalities	epithelial cancer	epithelial cancer	2.94E-06	 	-0.665	 	-0.387	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,RBM38,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,LHFPL2,HS6ST1,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,MT-ND2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,RBX1,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,ANKRD20A5P,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,VAT1,RPS15,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,C15orf59,RPLP0,TUBA1B,GFPT1,SNTA1,ITGA8,HLA-DQB1,MIEN1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,H2AFZ,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,NAP1L4,CD209,RRP1B,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,ANKMY2,FAM45A,RPL12,ATP10A,SLC39A3,GALNT13,TARS,ATP6V1A,TPSAB1/TPSB2,PREX1,TMEM189,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,RPS21,KIFAP3,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,SLCO2B1,MRPL24,DPT,PLD3,LHPP,ICT1,MTSS1,KLHL25,PAQR3,TNFRSF10B,MAD2L2,RUNDC3B,CARMIL1,ZNF69,TRAPPC1,PXDC1,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,TMEM41B,ATXN7L3,MRNIP,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,SDHAF1,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,BZW2,TRAF3,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,RNASE1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,UBA6,ARSA,MT-ND4L,GYS2,FOSB,SDCBP,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,SPCS1,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,SERINC2,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,MT-ND3,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,PSMB10,CDK16,CTNNA1,KAZN,ACSF2,FOLR2,PFKL,TAX1BP3,CA3,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,LAMP1,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,ADCK2,PEA15,PRMT5,P2RY12,SCAMP3,RUFY3,MAPRE3,MVD,GAB2,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,LMO4,GPS2,ANLN,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,ACOT4,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,SURF1,IRF5,CTSB,C15orf39,NHLH1,PLTP,FTH1,EPHX1,CD163L1,EVA1B,GADD45B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,SLC25A1,ENG,MAGEC3,MYO5A,RPS16,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,HSPB1,IGFBP4,LITAF,F2RL3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,FARS2,STAT1,MT-CO1,THBS4,TRIM55,IPO4,G6PD,TSN,KIF3B,APOLD1,APLP2,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,GSS,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,DHRSX,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,MYL12A,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,HIST1H1B,SNTG2,PI3,HIST1H1E,SLC48A1,CCDC85B,GLIS2,BRINP2,RHBDD2,TREM2,USP22,APOL4,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,RPL19,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,C1QBP,RET,BCKDK,C7orf50,MRPS15,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PACSIN3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,RAC1,CPVL,GPAA1,RASD1,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,EIF5A,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,TBCB,RRAGD,OAZ1,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,KIAA1683,ACSM2B,PLBD2,TMEM2,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,IP6K3,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TMEM201,PPTC7,FGFR2,FLOT1,TIMM8B,RHBDD1,BRF2,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,PRELP,UCK1,MARCH4,TULP3,LYPLA1,TMEM33,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,CD74,ZNF827,SLC35B2,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,LURAP1L,TTC23,FAM96B,ALDH5A1,FCGR3A/FCGR3B,G3BP2,WDR36,TMC2,SRA1,TRIB3,HSPA2,SPTLC3,GRN,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,SEMA3C,TSC22D2,TTYH3,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,KRTAP4-6,RHOG,ZNRF3,ENTPD5,ELP5,CDC42EP1,GCLM,PPP1CA,C17orf53,CBR1,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,NDUFA6,SLC25A39,CDH20,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SYCE1,SF3B5,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,HPS1,PWWP2B,NQO1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,SHB,CIDEA,KIFC3,KIF5B,TTL,EIF3I,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,TOR1A,TXNL4A,SH3BGRL3,HRAS,NCSTN,CECR1,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,PTPA,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,PIP,FANCE,UCHL1,RPL35,ACSM5,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,SLC7A6,NDUFS4,MBOAT7,LETM1,ADRM1,TYROBP,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,ACTR1A,EFR3A,SLC7A11,ATP5D,XPO5,RAB9A,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,TNFRSF12A,SEPHS2,HMOX1,RNF167,PCK2,NDUFC2,KCNMA1,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,COX17,CD160,VANGL1,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,NDUFA13,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,RTN3	1281	
Cell Morphology, Cellular Assembly and Organization	abnormal morphology	abnormal morphology of lysosome	3.03E-06	 	 	 	 	LAMP2,CTSA,ACP2,KIF5B,GAA,LAMP1,TPP1,NAGLU,ATP13A2	9	
Cancer, Organismal Injury and Abnormalities	growth	growth of tumor	3.16E-06	Increased	3.833	 	2.236	TGFBR1,AGER,HRAS,MKI67,CXCL9,ODC1,PEG10,CCND3,CTSS,ABCC1,PIK3CG,TXN,TP53,CERS6,RHEB,LAIR1,PAQR3,TNFRSF10B,FGFR2,ANXA2,HMGA1,HSPA8,BTG2,CTSB,GAPDH,ALCAM,SFRP1,SQSTM1,CYR61,ESR2,FTH1,NME1,FHL1,PIM3,DDIT3,BTG3,FGF2,GDF15,ADIPOQ,HYOU1,TAX1BP3,S100A7,UCHL1,OGT,JUN,HCAR2,ACVR1C,FCGR3A/FCGR3B,CCR1,EGR1,SLC39A6,LZTS2,ENG,SNCG,GRN,FOS,NR4A2,FCER1G,NR4A1,SOX9,SOCS3,ICMT,SLC7A11,SEPT9,DIRAS1,HSPA5,UBA2,HSPA4,PGD,PLCE1,SAE1,CXCL14,CYBB,HOXA7,SIAH2,GPC1,RET,PFKFB3,MIF,SPP1,PCSK6,RAC1,BAMBI,SLC3A2,ADCYAP1R1,IL1RN,ACKR3,CAPN2,INSR,CST6,AKR1B1,CD151,LITAF,LEP,PKM,HIF1A,RPS4X,FAS,NELFE,HDGF,RAP1GDS1,HLA-G,HMOX1,PARK7,EDN1,TIMP1,FLNA,THBS1,ANXA1,TGFB2,KIT,RHOBTB2,CYGB,CHCHD4,MCRS1,STAT1,NDUFAF3,PSMB4,COX17,CD160,HSPH1,MAPK9,CISD2,CSF1R,NDUFA13,FGF1,CXCL16,CISD1,EFEMP2	129	
Cell Death and Survival	cell death	cell death of liver	3.17E-06	 	-1.029	 	-0.030	SCD,APOE,SOCS3,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,FKBP1A,SMPD1,TMBIM6,TAF10,IL17RA,FAS,PTPRC,CXCL10,SLC19A3,HMOX1,ALDH2,JUN,TIMP1,FLNA,ENTPD5,SAA1,ITGAV,CFH,STAT1,NFE2L2,TP53,TYROBP,MAPK9,SOD1,IRF5,NFE2L1,APP,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,CD14,DUSP4,SLC25A5	46	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	immune response	immune response of leukocytes	3.35E-06	Increased	4.757	bias	2.714	GAB2,SOCS3,AGER,TLR8,CTSG,FCER1A,HLA-DQB1,BIN1,CXCL10,PTPRC,CD28,CTSS,PIK3CG,RET,CLCN3,TP53,EIF2AK1,PTX3,MIF,CAPG,CMC2,CD68,IL10RA,CD14,C3AR1,SIRPA,LCP2,APOE,MSR1,ERN1,SLC1A5,LGALS9,CD74,FAS,HMOX1,IGHG3,PTPRJ,THBS1,SAA1,ANXA5,ANXA1,STIM1,MAPKAPK2,FCGR3A/FCGR3B,SIGLEC1,PLXNA1,VCAM1,UCP2,TYROBP,FCGR2A,APP,ISG15,ITGB2,TREM2,FCER1G,IGHA1,P2RX7	57	
Cellular Assembly and Organization, Cellular Function and Maintenance	organization	organization of actin cytoskeleton	3.39E-06	 	1.486	bias	0.261	ARF1,ARPC5,SH3BGRL3,RAN,HRAS,CXCL9,DYNLL1,RHOG,CFL2,ABR,AFAP1,RFLNB,TMSB10/TMSB4X,RET,TP53,LCP1,MTSS1,CFL1,RAC1,MAD2L2,DMTN,MLST8,ARHGDIB,SIPA1L1,SLC3A2,ADAM12,PIP5K1C,ALDOA,SFRP1,PLEK,SIRPA,SPIRE1,RAP2A,LEP,PDGFA,FGF2,ENAH,PPP1R9B,EDN1,FLNA,SORBS1,ANXA1,TGFB2,KIT,ARHGEF2,AMOT,ACTN1,PRNP,SLC9A3R1,ENG,PDLIM4,KCTD13,FLNC,ARHGDIA,NCKAP1L,RUFY3	56	
Cell Death and Survival	cytotoxicity	cytotoxicity	3.39E-06	Increased	2.270	bias	0.424	ARL8B,CD2,FGF2,HLA-A,ADIPOQ,PPIA,HRAS,FKBP1A,CD74,FAS,IRAK1,PTPRC,POR,HLA-G,CD28,JUN,ABCC1,TOP2A,CYBB,LAMP1,KIT,NACC1,GCLM,TXN,STAT1,FCGR3A/FCGR3B,NDUFS4,TP53,LAIR1,TYROBP,FCGR2A,RAC1,PFDN5,SOD1,APP,HSPA8,FOS,ITGB2,CALM1 (includes others),IL1RN,FCER1G,CTSB,PLTP,ABCC3,P2RX7	45	
Cell Death and Survival	necrosis	necrosis of epithelial tissue	3.43E-06	 	0.168	 	-0.167	ICMT,SOCS3,CRYAB,TGFBR1,ITSN1,AGER,PIK3R1,CD4,ASS1,UNC5B,HRAS,TYMP,TMBIM6,HSPA5,CXCL10,SGPL1,DYNLL1,CTSS,ENTPD5,MCOLN3,ABCC1,ITGAV,TXN,TP53,HK1,MIF,SPP1,TNFRSF10B,RAC1,SDHC,IRF5,HAX1,IL1RN,MAPT,CTSB,GAPDH,INSR,SFRP1,VDAC1,ESR2,HSPB1,CD151,SCD,ADAM17,GADD45B,LEP,DDIT3,FGF2,PSMB10,ERN1,DUSP6,GDF15,HSPB8,CTNNA1,ADIPOQ,PPIA,SMPD1,CD74,FAS,CA3,HMOX1,ALDH2,JUN,EDN1,TIMP1,THBS1,SAA1,AAK1,DAB2,S100A8,STAT1,MAPKAPK2,NDUFAB1,NFE2L2,NLRC4,ATP13A2,PRNP,UCP2,EGR1,MAPK9,ENG,TRIB3,SOD1,CSF1R,FGF1,APP,RBCK1,FOS,MYOC,GLIS2,NTRK3,PEA15,NR4A1,FKBP4,CYCS,SLC25A5,P2RX7	97	
Cell Death and Survival	cell viability	cell viability of tumor cell lines	3.44E-06	Increased	5.402	bias	0.989	WHSC1,AGER,PIK3R1,RRM2B,HRAS,NCSTN,CXCL9,IP6K3,ABCC1,MCOLN3,TXN,TP53,RHEB,PPP1R1B,TNFRSF10B,FGFR2,HMGA1,DPH2,BTG2,PSMA4,SQSTM1,GSTP1,FTH1,APOE,ADAM17,FGF2,DUSP6,GDF15,HSPB8,KAZN,ASNS,SYNM,LYZ,JUN,SLC19A1,NACC1,ALPK2,FKBP5,NFE2L2,PTPRK,TBC1D9,TRIM28,ENG,APP,NTRK3,SREBF2,SBF1,NR4A1,PSAP,ABCC3,NCAM1,PRKACB,ABCB6,GAB2,SOCS3,DCUN1D5,SEPT9,TYMP,ZNF91,HSPA5,CTBP1,CAMK2D,PLCE1,DPP3,PACS2,NUPR1,CYBB,POMP,GPC1,RET,PPP1CA,BCKDK,CBR1,PSMA6,SPP1,ANLN,PHB2,RAC1,PSMC4,PFDN5,AURKAIP1,PPP1R11,KLF4,SEL1L,IL1RN,ACKR3,MAPT,CAPN2,INSR,UBE2I,RPSA,HSPB1,SCD,CARS,BARD1,PKM,SLC7A1,HIF1A,PLPP1,FAS,IRAK1,CLCN4,HLA-G,HMOX1,HINT1,PARK7,FLNA,DUSP10,VCP,KIT,PSMA3,SLC40A1,SELENOH,MAPKAPK2,ATP13A2,PRNP,PSMB4,USMG5,NPY1R,MAPK9,SOD1,NDUFA13,THRSP,ENO1,KIFC3,PPP2R1B,RPL38	127	
Cell Morphology, Cellular Function and Maintenance	transmembrane potential	transmembrane potential	3.44E-06	 	-0.211	 	-0.010	CRYAB,ITSN1,CD4,HSPA4,CD28,SLC25A6,ZBTB16,EYA2,TP53,RIMS3,PPP1R1B,TNFRSF10B,PHB2,RIMS4,RAC1,STOML2,MAPT,PRELID1,RTN4,VDAC1,ESR2,HSPB1,LEP,CD2,DDIT3,FGF2,BCO2,BARD1,DMD,SMPD1,HIF1A,FAS,HMOX1,PARK7,KCNMA1,VCP,STOX1,BCAP31,NDUFAB1,LONP1,NFE2L2,UCP2,CD160,GNA12,MAPK9,SOD1,CISD2,APP,CISD1,KIF5B,LGALS2,CYCS	52	
Cell Death and Survival	apoptosis	apoptosis of neurons	3.54E-06	 	-0.760	 	1.093	ITSN1,AGER,PIK3R1,MAP1B,UNC5B,HRAS,SH3GLB1,HSPA5,PANX1,SGPL1,LGMN,ATF4,GCLM,LANCL1,UNG,TP53,STXBP1,MIF,SURF1,MAD2L2,RAC1,CITED1,HAX1,RASD1,NR1D1,ADCYAP1R1,MAPT,BTG2,MAPK10,CTSB,GAPDH,AARS,INSR,ESR2,HSPB1,APOE,LEP,DDIT3,FGF2,HYOU1,HIF1A,FAS,HMOX1,JUN,PARK7,PPP1R9B,KCNMA1,TGFB2,NSMF,STAT1,ADORA1,FAM162A,NFE2L2,PRNP,MBOAT7,SCN2A,SIGMAR1,UCP2,HSPH1,EGR1,NQO1,G6PD,MT-ND4,MAPK9,SOD1,KIFAP3,CPEB4,APP,SERPINE2,FOS,NR4A2,NTRK3,PPT1,PEA15,CYCS	75	
Lipid Metabolism, Small Molecule Biochemistry	conversion	conversion of lipid	3.61E-06	 	1.430	bias	-0.019	APOE,SCD,LEP,APOB,AKR1C3,SRD5A1,CRAT,TECR,IRAK1,CERS2,POR,HMOX1,CYGB,CFH,NFE2L2,PRNP,TP53,AKR1C1/AKR1C2,MAPK9,FGFR2,ALOX5AP,SOD1,STS,APP,FTL,MAPT,ME2,INSR,C3AR1,CYP4A11,MAP4K4,GSTP1	32	
Dermatological Diseases and Conditions, Infectious Diseases	leprosy	leprosy	3.75E-06	 	 	 	 	CCR1,PSMB4,PLXNA1,IL2RG,CD160,MSR1,FCGR2A,CD4,GDF15,CTSG,FCER1A,ALOX5AP,FGFR2,CD83,APP,CD28,IGHG3,MAPT,FCER1G,CD14,SIRPA	21	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	migration	migration of macrophages	3.78E-06	Increased	2.383	bias	0.586	MIF,SPP1,TYROBP,ADIPOQ,RAC1,ENG,HIF1A,CD74,PLXND1,CSF1R,NINJ1,CXCL10,IL1RN,FLNA,TREM2,SH2B3,PIK3CG,CYBB,STAB1,MAPKAPK2,NLRC4,PRNP	22	
Cell Death and Survival	apoptosis	apoptosis of endothelial cells	4.22E-06	 	0.494	 	0.400	ICMT,ADAM17,LEP,TGFBR1,ITSN1,AGER,DDIT3,PSMB10,FGF2,DUSP6,ASS1,ADIPOQ,PPIA,HRAS,SMPD1,TYMP,CD74,HSPA5,FAS,HMOX1,ALDH2,EDN1,THBS1,S100A8,TXN,MAPKAPK2,NFE2L2,TP53,MIF,SPP1,UCP2,TNFRSF10B,RAC1,MAPK9,APP,CYCS,VDAC1	37	
Neurological Disease, Organismal Injury and Abnormalities	degeneration	degeneration of brain	4.30E-06	Decreased	-2.082	bias	0.025	ADIPOQ,VAC14,SMPD1,JUN,GBA,GLB1,CYBB,NMNAT2,CLCN3,STAT1,ADORA1,NFE2L2,UNG,NDUFS4,PRNP,ASNA1,SOD1,ARSA,NFE2L1,APP,MAPT,PPT1,CTSB,PSAP,SLC1A2,NAGLU,TPP1,CLCN7	28	
Neurological Disease	dyskinesia	dyskinesia	4.46E-06	 	 	 	 	CRYAB,AHCYL1,HRAS,GHITM,GNB1,CTSS,HADHB,PNKD,TXN,NAPA,ZBTB16,FBL,ATP5J,POLR2I,TP53,CSRP2,PPP1R1B,TPM3,NGRN,HSPA8,CD68,NR1D1,GAPDH,NDUFB2,APOE,GJB6,NME1,GBP1,DDIT3,FGF2,SRD5A1,SLC1A3,KAZN,PPIA,UCHL1,JUN,TMEFF1,MAL2,MYL12A,EGR1,SLIRP,PSMB6,MYO5A,FOS,PSME1,LAMP2,NTRK3,PPT1,UQCR10,FKBP4,NR4A1,TSPO,CYCS,SOX9,ADRA1A,PFN1,PFKFB1,ATP2B1,ATP5L,SDC4,HSPA5,DYNLT1,LDHB,AK1,RHOG,GAS5,ATP6V1A,LMCD1,FOSB,RARRES3,NDUFS3,ETV5,RPSA,SRM,SCD,COX7B,SDHB,LEP,SLC1A4,PKM,ALAS1,NDUFA2,HMOX1,ALDH2,HINT1,PREPL,KCNMA1,PPP1R2,SCN2A,PSAT1,ADCY2,CD160,TSN,GIT1,NDUFA13,KCTD13,CAPNS1,SLC14A1,SLC1A2,ATP6V1B2	100	
Cellular Compromise	degeneration	degeneration of cells	4.50E-06	Decreased	-2.309	bias	0.717	PIK3R1,HRAS,SLC9A1,CERS2,GNB1,CTSD,CFL2,MTMR2,TXN,RET,CLCN3,UNG,STXBP1,SPP1,PTPRQ,FGFR2,ARSA,OSTM1,IL1RN,MAPT,CTSB,NAGLU,INSR,HTRA1,ESR2,APOE,PIM3,UBQLN1,FGF2,ADIPOQ,SLC1A3,DMD,SMPD1,HIF1A,COL15A1,FAS,MAFG,UCHL1,JUN,PARK7,KCNMA1,TGFB2,TUB,NDUFS4,PRNP,TYROBP,SOD1,CISD2,CSF1R,KCNQ4,APP,FGF1,GRN,NR4A2,NTRK3,PPT1,TPP1,PSAP,SLC1A2,ARHGDIA,C6,NCAM1	62	
Cell Death and Survival, Cellular Compromise, Neurological Disease, Tissue Morphology	degeneration	degeneration of neurons	4.64E-06	Decreased	-2.450	bias	0.038	APOE,FGF2,UBQLN1,SLC1A3,SMPD1,HIF1A,SLC9A1,CERS2,MAFG,UCHL1,CTSD,JUN,PARK7,KCNMA1,TGFB2,TUB,MTMR2,RET,CLCN3,UNG,NDUFS4,PRNP,STXBP1,TYROBP,PTPRQ,FGFR2,SOD1,ARSA,CISD2,CSF1R,KCNQ4,APP,GRN,NR4A2,NTRK3,IL1RN,MAPT,PPT1,CTSB,TPP1,NAGLU,PSAP,SLC1A2,C6,ESR2,NCAM1	46	
Cellular Movement, Connective Tissue Development and Function	migration	migration of fibroblasts	4.66E-06	 	0.034	 	-1.212	RAP2A,APOE,LEP,TGFBR1,AGER,SNX17,FGF2,ADIPOQ,SDC4,RAMP2,CXCL10,SGPL1,EDN1,THBS1,CYGB,MAPKAPK2,TP53,DPT,SPP1,MRC2,GNA12,TMEM201,RAC1,DMTN,ENG,FGF1,CAPNS1,ARHGAP35,RAMP3,CYR61,TNS1	31	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of muscle cells	4.81E-06	Increased	2.814	 	1.490	SOCS3,AGER,PIK3R1,CMA1,FCER1A,HRAS,SDC4,SLC9A1,ODC1,CXCL10,CAMK2D,PLCE1,COMT,TXN,AIF1,TP53,MIF,SPP1,TNFRSF10B,RAC1,FGFR2,KLF4,NPR3,IL1RN,CTSB,CAPN2,INSR,AKR1B1,C3AR1,ESR2,SIRPA,IGFBP4,APOE,FHL1,ADAM17,LEP,FGF2,ADIPOQ,PPIA,SMPD1,HIF1A,H2AFZ,IRAK1,TNFRSF12A,C1QTNF9,HMOX1,JUN,EDN1,TIMP1,THBS1,VCP,KIT,STIM1,STAT1,NFE2L2,PRNP,NACA,EGR1,NQO1,EMD,ALOX5AP,POMGNT1,FGF1,FOS,CXCL16,NR4A2,NR4A1	67	
Molecular Transport	transport	transport of metal	4.98E-06	 	0.595	bias	-0.997	PER1,PLCB2,CRYAB,SLC31A1,YWHAH,KCND3,AHCYL1,ARF1,ATP2B1,CD4,MCUR1,PANX1,SLC9A1,CXCL10,CAMK2D,NEO1,SLC7A5,EIF2AK1,MIF,CFL1,STK39,STOML2,SLC39A3,SLC38A3,KCNG1,MAPT,COMMD1,RAMP3,ATOX1,VDAC1,STEAP3,FTH1,SLC24A2,FHL1,FGF2,HLA-A,SLC30A2,HIF1A,RAMP2,FAS,HMOX1,KCNMA1,SLC40A1,SCNN1B,ADORA1,NFE2L2,PRNP,CCR1,SCN2A,LETM1,AP3D1,SLC12A2,SLC39A6,TRPA1,KCNJ3,SOD1,KCNQ4,APP,CISD1,TRPM6,FTL,APLP2,KIF5B,FKBP4,FECH,SLC1A2,BMPER,P2RX7	68	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	activation	activation of macrophages	4.99E-06	 	1.221	bias	-0.601	APOE,GJB6,TRAF3,TOLLIP,LEP,DDIT3,MSR1,HLA-A,CD4,MAF,ADIPOQ,IRAK1,TNFRSF12A,CXCL10,HMOX1,EDN1,THBS1,DUSP10,CYBB,ITGAV,STAT1,ADORA1,PRNP,TP53,MIF,TYROBP,ANXA2,SOD1,KLF4,CSF1R,PLA2G2A,SPON2,APP,OSTM1,IL1RN,TREM2,MAPT,PPT1,SLC7A2,FCER1G,CD14,CLCN7,C6,SIRPA,P2RX7	45	
Cancer, Organismal Injury and Abnormalities	metastatic carcinoma	metastatic carcinoma	5.17E-06	 	 	 	 	S100A11,SCD,PPIA,FKBP1A,RNASE1,HIF1A,FAS,POR,PTPRC,TOP2A,IFI30,KIT,TUBA1C,RET,CLCN3,TMSB10/TMSB4X,MYL12A,TP53,IL2RG,NDUFB4,SPP1,TUBB4B,EPB41L4B,TUBG1,TUBB2A,FGFR2,CSF1R,ATIC,FTL,DUSP4,SFRP1,INSR,ABCC3,ESR2	34	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of phagocytes	5.18E-06	Increased	2.057	bias	-0.243	APOE,GAB2,CRYAB,ADAM17,APOB,LEP,PLGRKT,CD4,CTSG,ADIPOQ,CD74,IL17RA,CXCL10,CD28,LYZ,EDN1,THBS1,ANXA1,PIK3CG,S100A8,NFE2L2,HCAR2,FCGR3A/FCGR3B,CCR1,PTX3,MIF,VCAM1,UCP2,SPP1,FCGR2A,RAC1,ST3GAL6,ALOX5AP,F13A1,FLOT1,IRF5,CSF1R,APP,ITGB2,PREX1,PIP5K1C,IL1RN,RTN4,CD14,SFRP1,CYR61,C3AR1	47	
Cellular Movement	cell movement	cell movement of connective tissue cells	5.21E-06	 	1.103	bias	-0.848	APOE,RAP2A,TGFBR1,LEP,SLC4A2,AGER,FGF2,SNX17,ADIPOQ,HRAS,DMD,SDC4,RAMP2,ENAH,CXCL10,SGPL1,JUN,EDN1,THBS1,KCNMA1,CYGB,MAPKAPK2,WNT5B,TP53,MIF,DPT,SPP1,MRC2,GNA12,TMEM201,RAC1,DMTN,ENG,CSF1R,FGF1,FOS,CXCL16,CAPNS1,ARHGAP35,CAPN2,RAMP3,CYR61,TNS1	43	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of phagocytes	5.21E-06	Increased	4.590	bias	 	PFN1,CD4,CTSG,CXCL9,CXCL10,CD28,PIK3CG,CXCL14,CYBB,C1QBP,AIF1,TMSB10/TMSB4X,MIF,SPP1,RAC1,FLOT1,CAPG,TPSAB1/TPSB2,NINJ1,PREX1,PIP5K1C,C3AR1,CD151,APOE,LITAF,DAPK2,PPIA,CD74,S100A7,PTPRJ,EDN1,THBS1,SAA1,ANXA1,TGFB2,STIM1,S100A8,ADORA1,MAPKAPK2,HCAR2,PRNP,CCR1,RPS19,THBS4,FCGR2A,MAPK9,GIT1,CSF1R,APP,GRN,ITGB2,MT-ND1,FCER1G,NCKAP1L	54	
Nucleic Acid Metabolism	metabolism	metabolism of nucleic acid component or derivative	5.31E-06	 	1.589	bias	-0.417	ICMT,SOCS3,GFPT1,ATP5D,AGER,RRM2B,NME2,LHCGR,ATP5L,HRAS,TYMP,APRT,GNB1,NNMT,POR,AK1,PGD,G0S2,UQCC2,CYP3A5,COMT,ENTPD5,PIK3CG,NMNAT2,MDH2,TP53,ATP5J,SPP1,GLYAT,TALDO1,SURF1,CTPS1,PDE1C,HSPA8,ADCYAP1R1,MAPT,ALDOA,RAMP3,ACOT4,INSR,VDAC1,RPSA,APOE,ATP5G1,LEP,CHCHD10,FGF2,PKM,SMPD1,COASY,ME1,HIF1A,DTYMK,RAMP2,FAS,ALDH2,HMOX1,CES1,EDN1,THBS1,VCP,ATP5J2,MT-CO3,BHMT2,HCAR2,LONP1,PRNP,MT-ATP6,ADCY2,UCP2,LETM1,USMG5,DCTPP1,NQO1,G6PD,SOD1,GUK1,ATIC,APP,MRAP,GIPR,ADCY1,P2RY12,PANK3,CYCS,SLC25A5	86	
Cellular Development	differentiation	differentiation of cells	5.32E-06	Increased	3.035	 	-0.431	CSTA,TGFBR1,KDM6B,AGER,PIK3R1,CTSG,C1QC,PANX1,SLC9A1,ODC1,SPRY4,PTPRC,POR,ALPK3,CCND3,SRPX2,AJUBA,KEAP1,MCOLN3,SPTB,ATF4,PLXNB2,LMX1A,MYBBP1A,RRAGC,TP53,FBL,SLC2A5,RBM38,LCP1,RHEB,YWHAG,LAIR1,PPP1R1B,PAQR3,TNFRSF10B,MAD2L2,FGFR2,ANXA2,IRF5,RHBDD1,HAX1,DSG1,BTG2,CTSB,GAPDH,ALCAM,SQSTM1,ESR2,APOE,RAP2A,NME1,PIM3,GADD45B,DDIT3,SLC1A5,FGF2,HLA-DQA1,ADIPOQ,LGALS9,PPIA,ATRAID,CD74,PTPRJ,OSBPL11,DAB2,ADORA1,AMOT,NFE2L2,CCR1,SIGMAR1,SRA1,IGKC,GNA12,MESP1,ENG,TRIB3,HSPA2,CPEB4,ISG15,GRN,MYO5A,MRAP,FOS,MYOC,KIF7,NR4A2,PIR,NTRK3,FLNC,NR4A1,SOX9,STK31,BMPER,DCX,ADRA1A,PRKACB,SOCS3,TRAF3,AKR1C3,MBP,NME2,NRN1,HSPA5,BIN1,NNMT,CD28,HS6ST1,HSF4,RHOG,CXCL14,HOXA10,HOXA7,PPP1CA,IL2RG,STK39,PTPRQ,RIMS4,CREG1,UBA6,CITED1,KLF4,TXNRD1,SLC3A2,METRN,SPINK5,PIK3AP1,INSR,HTRA1,CBX3,SIRPA,UBE2I,ETV5,DOK5,PTGFR,SCD,ANGPTL8,SUMO3,DMD,IL17RA,HNRNPK,CIAPIN1,HLA-G,EDN1,TIMP1,RNH1,STAT1,IARS,LONP1,KRT14,CAPZB,AKR1C1/AKR1C2,NPY1R,HPS1,SOD1,GIT1,KIF3B,NFE2L1,FGF1,SERPINE2,SHB,RPS15,CAPNS1,KIF5B,TTL,FECH,ITSN1,MAF,ARPC5,HRAS,HLA-DQB1,GLO1,CXCL10,ZBTB7B,SGPL1,DYNLL1,PEG10,MKX,PIK3CG,POU6F2,NAPA,ZBTB16,EYA2,WNT5B,SFRP4,RIMS3,CFL1,TSPAN33,HMGA1,BCAP29,MTPN,NR1D1,PRELID1,IL10RA,RTN4,GLUL,SFRP1,CYR61,ITGA7,C3AR1,RORB,LCP2,ADAM17,RPS3A,TCEA1,BTG3,SLC1A3,GPC4,SDC3,H2AFZ,ATP6AP1,MAFG,CES1,JUN,SRGAP1,TOP2A,SNX10,LAMP1,TRIM16,STIM1,SARS,ACVR1C,MBOAT7,RPS19,TYROBP,EGR1,APP,ITGB2,CCDC85B,GLIS2,SOX6,SBF1,TENM4,BRINP2,TREM2,FCER1G,PRMT5,NR5A2,P2RY12,NPC2,NCAM1,HOXB5,GAB2,PFN1,CD4,MAP1B,UNC5B,TAF10,DYNLT1,CD63,CTBP1,HIST1H4C,SIAH2,GPC1,C1QBP,HIST1H4H,RET,EIF2AK1,MIF,SPP1,LMO4,ANLN,PHB2,RAC1,SIPA1L1,RASD1,TPSAB1/TPSB2,OSTM1,SEL1L,PREX1,IL1RN,SH2B3,MAPT,RARRES3,CD14,GNL3,LFNG,EIF5A,SPRED1,LEP,STMN2,CD2,ATF5,NLGN1,ERN1,PKM,SMPD1,CD83,HIF1A,FAS,TNFRSF12A,HMOX1,THBS1,KCNMA1,ANXA1,DUSP10,TGFB2,KIT,S100A8,ALPL,NLRC4,PRNP,NACA,BHLHE41,MRC2,AP3D1,MAPK9,MKNK2,CSF1R,EDF1,KCNQ4,ENO1,KIF2A,EPHB3,SLC1A2,NCKAP1L,P2RX7,UBE2D3,CARM1	319	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	cytochrome c oxidase deficiency	cytochrome c oxidase deficiency	5.35E-06	 	 	 	 	MT-CO1,SURF1,COX14,MT-CO3,MT-TE,MT-CO2,COA3,MT-TN,MT-TL1	9	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities	lysosomal storage disease	lysosomal storage disease	5.44E-06	Decreased	-2.930	bias	 	APOE,FUCA1,ACP2,GM2A,HEXA,SMPD1,ARSA,GRN,CTSD,CTSA,GBA,GLB1,IL1RN,PPT1,ALDH3A2,TPP1,NAGLU,CD14,PSAP,CLCN7,ATP13A2,NPC2	22	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function	aggregation	aggregation of blood cells	5.49E-06	 	1.997	 	0.664	PLCB2,SLC7A11,LEP,F2RL3,AGER,PIK3R1,CD4,GDF15,CTSG,ADIPOQ,HIF1A,CXCL9,CD63,CXCL10,CES1,RHOG,TIMP1,THBS1,FLNA,PIK3CG,LAMP1,ITGAV,DAB2,ANXA7,CFH,MYL12A,TP53,PTX3,CD209,STXBP1,FCGR2A,DMTN,APP,SERPINE2,MYL9,ITGB2,PIP5K1C,FCER1G,P2RY12,PLEK,AKR1B1,ACTG1,LCP2,HSPB1,CD151	45	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	polyarticular juvenile rheumatoid arthritis	polyarticular juvenile rheumatoid arthritis	5.49E-06	 	 	 	 	RPL32,CCR1,APOE,GADD45B,HSPB8,CD83,CD74,IL17RA,FOSB,HLA-G,PTPRC,FOS,NR4A2,THBS1,HLA-DRA,NR4A1,SLC1A2,S100A8,TXN,PRNP,RPSA	21	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast cancer	stage 3 breast cancer	5.49E-06	 	 	 	 	KRT14,NME1,SLC9A3R1,TUBB4B,TUBG1,TUBB2A,LHCGR,NME2,FGFR2,KRT5,HMOX1,FIS1,JUN,C19orf53,KIT,TUBA1C,AIDA,LYPLA1,CBX3,ESR2,GJB2	21	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of mononuclear leukocytes	5.61E-06	Increased	4.218	bias	1.387	SOCS3,PLCB2,TGFBR1,AGER,CD4,PIK3R1,UNC5B,CTSG,FCER1A,HRAS,CXCL9,CHST2,CXCL10,CD28,SGPL1,CTSS,ABCC1,PIK3CG,ITGAV,STAB1,AIF1,TP53,LCP1,MIF,SPP1,RAC1,ANXA2,FYB,NINJ1,EFS,ACKR3,YARS,PIP5K1C,MAPK10,ESR2,SIRPA,LCP2,CD151,RAP2A,APOE,ADAM17,LEP,CD2,HLA-A,HYOU1,PPIA,SMPD1,CD74,IL17RA,FAS,S100A7,HLA-G,HMOX1,JUN,TIMP1,THBS1,ANXA1,CCL28,SAA1,STAT1,KRT10,GJB2,PRNP,CCR1,RPS19,CD209,VCAM1,UCP2,GNA12,NQO1,ENG,APP,FOS,CXCL16,ITGB2,GLIS2,NR4A1,C6,P2RX7	79	
Cellular Function and Maintenance	ion homeostasis	ion homeostasis of cells	5.65E-06	Increased	3.317	bias	1.221	PLCB2,SLC31A1,AGER,ARF1,MBP,CD4,SNTA1,NME2,FCER1A,HSPA5,SLC9A1,GNB1,PTPRC,CXCL10,CD28,CAMK2D,PLCE1,STC2,ABCC1,PIK3CG,CYBB,ITGAV,HOXA7,NEO1,ANXA7,CLCN3,TP53,EIF2AK1,SFRP4,SPP1,STK39,SLC24A3,RAC1,STOML2,ANXA2,CD52,MAPT,RTN4,COMMD1,ATOX1,EIF5A,AKR1B1,C3AR1,CYP4A11,LCP2,APOE,FPR3,SLC24A2,LEP,SLC4A2,CD2,FGF2,ADIPOQ,PPIA,SMPD1,HIF1A,FAS,MAFG,HMOX1,JUN,EDN1,KCNMA1,ANXA1,CCL28,SAA1,KIT,STIM1,SLC40A1,BCAP31,SCNN1B,FCGR3A/FCGR3B,PRNP,CCR1,SIGMAR1,UCP2,LETM1,SLC9A3R1,FCGR2A,SLC12A2,GNA12,SLC39A6,TRPA1,SOD1,APP,FIS1,ITGB2,FTL,GIPR,APLP2,SLC14A1,PAG1,FECH,ABCC3,P2RX7,ADRA1A,ATP6V1B2	96	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation	proliferation of cancer cells	5.71E-06	 	1.795	 	0.469	ICMT,SOCS3,HRAS,DIRAS1,MKI67,UBA2,ODC1,SAE1,PEG10,PLCE1,CCND3,CTSS,RET,TP53,PFKFB3,MIF,RHEB,SPP1,LAIR1,BAMBI,ADCYAP1R1,IL1RN,BTG2,CTSB,SFRP1,SQSTM1,INSR,CYR61,CST6,AKR1B1,ESR2,CD151,LITAF,FHL1,PIM3,LEP,DDIT3,FGF2,GDF15,ADIPOQ,HIF1A,RPS4X,TAX1BP3,NELFE,HDGF,S100A7,JUN,EDN1,THBS1,TGFB2,KIT,RHOBTB2,MCRS1,STAT1,ACVR1C,COX17,CD160,EGR1,LZTS2,FGF1,GRN,FOS,NR4A2,NR4A1	64	
Cardiovascular Disease, Hematological Disease	anemia	anemia	5.88E-06	Decreased	-2.834	bias	 	SLC7A11,RRM2B,GSS,PTPRC,CD28,AK1,LGMN,CCND3,SPTB,ATF4,C1QBP,MGAT1,TP53,EIF2AK1,HK1,RBM38,MIF,RAC1,DMTN,TSPAN33,CD52,TXNRD1,CCND2,SH2B3,ALDOA,ESR2,STEAP3,APOE,TCEA1,CUBN,SLC7A1,RPL26,GPC4,HIF1A,FAS,FANCE,ALDH2,HMOX1,EDN1,PTPRJ,ANXA1,KIT,SLC40A1,CFH,NFE2L2,FCGR3A/FCGR3B,RPS24,MT-CO1,RPS19,VCAM1,FCGR2A,TUBB4B,TRIM28,EGR1,NQO1,RPS10,G6PD,SOD1,RPS29,NFE2L1,FCER1G,TPP1,P2RY12	63	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cell movement	cell movement of lymphocytes	5.90E-06	Increased	3.220	bias	0.576	SOCS3,PLCB2,TGFBR1,CD4,PIK3R1,CTSG,FCER1A,HRAS,CXCL9,CHST2,CXCL10,CD28,SGPL1,CTSS,PIK3CG,ABCC1,ITGAV,STAB1,TP53,LCP1,MIF,SPP1,RAC1,FYB,EFS,ACKR3,PIP5K1C,MAPK10,ESR2,LCP2,CD151,RAP2A,ADAM17,LEP,CD2,HLA-A,HYOU1,PPIA,SMPD1,CD74,IL17RA,FAS,S100A7,HLA-G,HMOX1,JUN,TIMP1,THBS1,ANXA1,CCL28,SAA1,STAT1,KRT10,GJB2,CCR1,CD209,VCAM1,UCP2,GNA12,NQO1,ENG,APP,FOS,CXCL16,ITGB2,GLIS2,NR4A1,C6,P2RX7	69	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of ganglioside GM2	5.97E-06	 	 	 	 	GBA,GLB1,GM2A,HEXA,SMPD1,NPC2	6	
Cellular Movement, Connective Tissue Development and Function	migration	migration of cardiac fibroblasts	5.97E-06	 	-0.555	 	-0.555	CXCL10,DPT,LEP,SPP1,FGF2,ADIPOQ	6	
Nucleic Acid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of nucleotide	6.24E-06	 	1.735	bias	-0.098	SOCS3,ATP5D,AGER,RRM2B,LHCGR,NME2,ATP5L,HRAS,TYMP,GNB1,NNMT,AK1,PGD,G0S2,UQCC2,ENTPD5,PIK3CG,NMNAT2,MDH2,TP53,ATP5J,SPP1,TALDO1,SURF1,CTPS1,PDE1C,HSPA8,ADCYAP1R1,MAPT,ALDOA,RAMP3,INSR,VDAC1,RPSA,APOE,ATP5G1,LEP,CHCHD10,FGF2,PKM,SMPD1,COASY,HIF1A,ME1,DTYMK,RAMP2,FAS,HMOX1,ALDH2,EDN1,THBS1,VCP,ATP5J2,MT-CO3,HCAR2,LONP1,ADCY2,MT-ATP6,UCP2,LETM1,USMG5,DCTPP1,NQO1,G6PD,SOD1,GUK1,APP,MRAP,GIPR,ADCY1,PANK3,P2RY12,CYCS,SLC25A5	74	
Organismal Injury and Abnormalities	oxidative stress	oxidative stress	6.37E-06	Decreased	-2.144	bias	 	TP53,APOE,PRDX5,CA5B,ADIPOQ,SOD1,NFE2L1,APP,HMOX1,JUN,NR4A2,PLIN5,GCLM,SQSTM1,LANCL1,NFE2L2,FTH1,NDUFS4,HSPB1	19	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	invasion	invasion of tumor	6.63E-06	Increased	2.530	bias	0.787	APOE,GAB2,NME1,TRAF3,TGFBR1,LEP,FGF2,GDF15,LHCGR,ADIPOQ,HRAS,FKBP1A,TYMP,HIF1A,HSPA5,FAS,MIEN1,S100A7,HMOX1,RHOG,PARK7,EDN1,CTSS,FLNA,THBS1,RHOBTB2,S100A8,GPC1,ZBTB16,NFE2L2,TP53,CD53,SPP1,GNA12,PCSK6,RAC1,ANXA2,KLF4,CTSB,ALCAM,CD14,CAPN2,SFRP1,CST6,CD151	45	
Cancer, Organismal Injury and Abnormalities	abdominal cancer	abdominal cancer	6.72E-06	 	0.478	 	0.907	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,VIT,DEFB132,DCAF12,RNPEPL1,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,WBP2,RPL37,GALNT4,CYP4F11,AKR1C3,EML4,DIRAS1,INTS1,LHFPL2,HS6ST1,HSF4,STC2,ANKDD1A,TUBA1C,MTMR2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,TXNDC12,CXXC5,FECH,SLC25A5,EFEMP2,MAP4K4,RPLP0,GFPT1,SNTA1,ITGA8,HLA-DQB1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,HMGA1,NINJ1,ACAD11,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,ATP6AP1,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,CD53,SIGLEC1,NAP1L4,CD209,RRP1B,ANKRD9,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,TMEM230,DPP3,COMT,CHST11,NMNAT2,PGP,GOT1,TBC1D10C,TMEM53,C5orf15,ACP2,RPL29,ANKMY2,FAM45A,RPL12,ATP10A,GALNT13,SLC39A3,TARS,TPSAB1/TPSB2,PREX1,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,FAM171A2,SSU72,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,TPST2,SZRD1,KIFAP3,ANO2,PAG1,RPS27L,MZT2B,NCKAP1L,PPP2R1B,HLTF,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,ODC1,SUSD1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,SPTB,PLEKHO2,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,DPT,PLD3,ICT1,LHPP,MTSS1,PAQR3,TNFRSF10B,MAD2L2,CARMIL1,RUNDC3B,ZNF69,CD52,TRAPPC1,PXDC1,ARHGDIB,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,MRNIP,TMEM41B,ATXN7L3,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,DEAF1,ESR2,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,AASDHPPT,PEX3,NACC2,SFXN4,FBXO10,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,HCAR2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,GNA12,FUCA2,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,C6orf62,BTF3L4,BMPER,SIM1,PPIL1,ADRA1A,HAGH,BZW2,NCDN,MEGF9,USP5,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,GULP1,PFKFB3,IL2RG,RILPL1,TNPO1,DMTN,UBA6,ARSA,MT-ND4L,GYS2,FOSB,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TFPT,TMEM176B,CALHM2,PTGFR,ERAP2,SLC1A4,MECR,DENND4B,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,SLC12A2,ZNF511,ST3GAL6,NMT2,S100A2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,HADHB,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,PIP5K1C,YARS,MS4A4A,MS4A7,IL10RA,ALDOA,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,CDK16,CTNNA1,ACSF2,PFKL,DCLK2,IGHG3,SRGAP1,CCL28,ANXA5,HLA-DRA,NACC1,RPS12,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,MFAP4,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,MRPL51,COL5A3,UQCR10,PIGK,PEA15,P2RY12,SCAMP3,RUFY3,MAPRE3,HOXB5,MVD,GAB2,DYNLT1,CYBB,IFI30,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,GPS2,ANLN,PSMC4,UQCR11,MARS,EIF2S2,UBE2D2,MPP3,IL1RN,MAPK10,HSPA13,AKR1B1,HIST2H2AB,UBE2J2,SPX,LEP,CD2,STMN2,ERN1,NLGN1,PRDX5,PDGFA,FAM47E,GANAB,RRP36,PLPP1,RAMP2,SLFN5,FLNA,SENP3,HIST2H2AC,PSMA3,S100A8,CCDC73,SLC40A1,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,SHMT2,ATP6V1B2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,AIF1,KNSTRN,RPA4,SLC2A5,FBL,YWHAG,SURF1,IRF5,CTSB,C15orf39,PLTP,EPHX1,CD163L1,EVA1B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,IGKC,SLC25A1,ENG,MAGEC3,MYO5A,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,BAMBI,CREG1,FYB,TXNRD1,DYNLRB1,SLC7A2,TNS1,HSPB1,IGFBP4,LITAF,F2RL3,DNASE1L3,PLGRKT,BARD1,HABP4,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,FARS2,STAT1,MT-CO1,THBS4,TRIM55,IPO4,G6PD,TSN,APOLD1,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,DPH2,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,BTG3,OXLD1,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,NPTXR,ZFAND2B,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,SLC48A1,GLIS2,RNF144A,BRINP2,RHBDD2,TREM2,USP22,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,GSPT1,CAMK2D,SLC25A6,ALDH3A2,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,RILP,HIST1H4H,RET,MDH2,BCKDK,C7orf50,MFSD3,HK1,SHOC2,PRKRA,FUCA1,ACSL3,PACSIN3,TRIOBP,GSDMB,XYLT1,HSPA9,TALDO1,RAC1,CPVL,GPAA1,RASD1,EVI2B,SH2B3,TMEM176A,MAPT,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,ARL2,SPIRE1,SRM,COPS4,SDHB,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,RRAGD,OAZ1,SOX18,MAPKAPK2,KCTD1,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,PHLDA3,OAF,VSIG4,KCNJ3,GUK1,MRPS16,PLXND1,KIAA1683,ACSM2B,PLBD2,TMEM2,APOC1,EPHB3,SLC1A2,GBE1,PDE8B,C6,VAMP8,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,TMSB10/TMSB4X,UNG,TP53,ATP5J,LCP1,UXS1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TSPYL5,TMEM201,PPTC7,FGFR2,TIMM8B,TPM3,FLOT1,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,BTG2,GAPDH,UCK1,MARCH4,TULP3,TMEM33,LYPLA1,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CCDC167,CKAP4,ZNF827,CD74,SLC35B2,GLIPR1,LAMP3,COL16A1,SHTN1,SORBS1,OSBPL11,TTC23,ALDH5A1,FCGR3A/FCGR3B,G3BP2,TMC2,WDR36,SRA1,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,NR4A2,ALDH1L2,MOBP,FLNC,FAM129A,PPT1,MBD3,USP46,TSC22D2,TTYH3,SEMA3C,ABCC3,CSTF3,PTER,ABCB6,ICMT,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,KRTAP4-6,ZNRF3,RHOG,ENTPD5,ELP5,CDC42EP1,GCLM,CHMP1A,C17orf53,LACTB,TOP3B,GM2A,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,SLC25A39,CDH20,NDUFA6,CAPN2,MRPS2,PIK3AP1,MEGF8,SIRPA,DOK5,ATP6V0C,UBXN1,SYCE1,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,TOX2,STOX1,MCRS1,LONP1,TSSK4,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,PWWP2B,NQO1,HPS1,EMD,TRPA1,PDLIM4,LARP6,NRBF2,CISD2,GIT1,FGF1,ANGPTL5,CXCL16,SHB,CIDEA,LGALS2,KIF5B,TTL,EIF3I,GZF1,GXYLT2,TMEM266,CADM3,KCNK15,SLC29A4,APOB,ITSN1,C9orf72,AHCYL1,TOR1A,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,NANOS1,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CPA3,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,LAPTM5,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,ADAP2,TTC1,SLBP,RNF24,PIP,FANCE,UCHL1,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,STIM1,PSMD14,TPO,TP53RK,AMFR,PI4KA,SLC7A6,NDUFS4,MBOAT7,LETM1,ADRM1,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,SNRPC,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,GABARAP,ACTR1A,EFR3A,MT-TT,SLC7A11,XPO5,RAB9A,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,MTCH2,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,SEPHS2,HMOX1,RNF167,PCK2,NDUFC2,KCNMA1,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,CD160,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1246	
Cellular Compromise	stress response	stress response of cells	6.76E-06	 	-0.285	 	-0.504	LEP,AGER,DDIT3,ERN1,PIK3R1,TMBIM6,HIF1A,HSPA5,HMOX1,CTSD,CTSS,GAA,ALDH3A2,VCP,ATF4,STIM1,ISCU,NFE2L2,PRNP,TP53,NQO1,SOD1,NFE2L1,APP,MAPT,CTSB,CD14,SQSTM1,INSR	29	
Organismal Injury and Abnormalities	cytosis	Cytosis	7.08E-06	Decreased	-3.281	bias	-1.615	SOCS3,RRM2B,SH3GLB1,CERS2,ABR,SPTB,ANXA7,STAM,TUBA1C,RET,CLCN3,TP53,SPP1,LAIR1,ACP2,TUBB2A,RAC1,PSMC4,DMTN,ARSA,HAX1,OSTM1,IL1RN,MAPT,SH2B3,CTSB,CLCN7,SQSTM1,INSR,ESR2,STEAP3,APOE,GJB6,FGF2,ADIPOQ,SMPD1,HIF1A,PDGFC,KCNMA1,LAMP1,KIT,NFE2L2,ALDH5A1,FCGR3A/FCGR3B,ATP13A2,NDUFS4,PRNP,FCGR2A,TUBB4B,TUBG1,SOD1,CSF1R,APP,GRN,ITGB2,TREM2,PPT1,PSAP,SEMA3C	59	
Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	digestive system cancer	digestive system cancer	7.26E-06	 	-0.528	 	-0.073	TGFBR1,PCLO,C1QTNF5,ASS1,GARS,VAC14,LRRN4CL,GNB1,POR,GLB1,AJUBA,DEFB132,VIT,DCAF12,RNPEPL1,SRPRA,LARP4,ANXA2,MYL9,NPR3,RCC2,PSMA4,ALCAM,ELMO2,ACTG1,KDM1B,BANK1,FHL1,DDIT3,GBP1,SLC1A5,SNX17,ADIPOQ,PPIA,MFSD5,SYNM,RABL6,ACSS3,ALPK2,SCNN1B,AMOT,MTSS1L,CASKIN1,RNF157,IPO7,PSMB6,MTHFD1L,AFF3,KIF7,ATP6V1F,DERL1,NR4A1,RPL37,CYP4F11,AKR1C3,EML4,INTS1,LHFPL2,HSF4,STC2,TUBA1C,MTMR2,NSMAF,GUF1,PIK3R3,SPINK5,CCDC43,NAGLU,TMX2,INSR,KCTD19,CBX3,POLD2,FAM134A,ETV5,SCD,FOXRED2,SUMO3,CARS,FLRT1,FAT3,NHP2,RPL7A,HDGF,IGSF8,CFH,NDUFB4,AKR1C1/AKR1C2,RNF26,TCEA3,SNTB1,PYGB,SOD1,SAA2,SNX27,DHX8,VAT1,TXNDC12,FECH,EFEMP2,MAP4K4,RPLP0,SNTA1,ITGA8,HLA-DQB1,ZBTB7B,SCYL2,SGPL1,TMEM268,SLC22A15,PXK,PNKD,GPR26,ZBTB16,POLR2I,UBXN6,COMMD9,CNOT10,MALSU1,NINJ1,SNRNP25,ARHGAP35,ZNF629,LRP2BP,FCGRT,HLA-A,TSGA10,ST6GALNAC4,FKBP1A,COASY,ASTE1,SDC3,RNF185,CADM2,MYO5C,MT-CYB,DIP2B,TUB,TXNL1,RPS5,FKBP5,RNF135,GJB2,LIMCH1,RPS24,SIGLEC1,NAP1L4,CD209,RRP1B,ANKRD9,EGR1,TRIM28,COPS3,STS,AIP,CALM1 (includes others),C8orf33,SOX6,SBF1,AOX1,NCAM1,LHCGR,FAM127B,ZNF91,RSPO3,CNDP2,PLCE1,CFL2,DPP3,TMEM230,COMT,CHST11,NMNAT2,GOT1,TMEM53,TBC1D10C,C5orf15,ACP2,ANKMY2,FAM45A,RPL12,ATP10A,GALNT13,SLC39A3,TARS,PREX1,UBE2G1,TOMM34,TSTD1,CYP4A11,FPR3,PCDHAC2,PCDH19,MAN1B1,RPS4X,CLCN4,PLEKHM1,HINT1,THBS1,DUSP10,CYGB,ASAP3,PSMB4,TMEM220,SZRD1,KIFAP3,ANO2,PAG1,RPS27L,NCKAP1L,PPP2R1B,HLTF,CSTA,CRYAB,IGSF6,PCDHAC1,LRRC1,KCMF1,CLSTN2,SLC35C1,CXCL9,PANX1,SUSD1,ODC1,NPL,SKIV2L,GATAD2A,SRPX2,ARID3B,HIGD2A,COMMD2,PLEKHO2,SPTB,B3GNT9,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,DPT,PLD3,MTSS1,ICT1,LHPP,KLHL25,PAQR3,MAD2L2,CARMIL1,RUNDC3B,ZNF69,TRAPPC1,PXDC1,HAX1,NRBP1,SLC7A10,SCUBE1,TMEM55A,MRNIP,TMEM41B,ATXN7L3,AACS,CYP4B1,ABCF3,DUSP4,AARS,CHD1L,SQSTM1,ESR2,DEAF1,TRAPPC5,MRPL37,FKBP2,LMBRD2,APOE,NME1,FBXO10,SFXN4,SLC4A2,CDH18,CUBN,HS2ST1,GDF15,HLA-DQA1,EEF1B2,LGALS9,CRAT,COPS8,TECR,KRTDAP,OGT,TMEFF1,PTPRJ,TNXB,PEX10,PLIN2,ATP5J2,DAB2,ANKRD53,ASPH,ADORA1,NFE2L2,KRT10,P4HA2,CCR1,S100A1,SIGMAR1,RPL4,FUCA2,GNA12,DGAT2,SLC39A6,STON1,LZTS2,TMEM25,SNCG,C1orf122,CPEB4,ISG15,TBC1D13,MYOC,NTRK3,RSPO1,KRT6A,TPP1,PSAP,ARHGDIA,BTF3L4,BMPER,SIM1,PPIL1,HAGH,ADRA1A,BZW2,NCDN,MEGF9,TMEM8A,ABCA3,PPFIBP2,NME2,TLR8,NRN1,TYMP,IMP4,CES2,SLC35F6,BIN1,NNMT,CD28,TMEM132C,SAE1,CYP3A5,MOCOS,GDE1,CXCL14,PACS2,HOXA10,NUPR1,HOXA7,STAB1,CNTNAP1,DPM3,PFKFB3,IL2RG,RILPL1,TNPO1,UBA6,ARSA,MT-ND4L,GYS2,TLN2,PDCL3,ADAM12,UHRF1BP1L,HTRA1,CCPG1,CST6,TMEM176B,TFPT,CALHM2,PTGFR,ERAP2,SLC1A4,DENND4B,MECR,SLC38A1,IRAK1,RAP1GDS1,TIMP1,FYTTD1,DNAJC4,ZNF483,ADCK3,LOC102724428/SIK1,RHOBTB2,CIZ1,IARS,ATP13A2,FAM171B,VCAM1,ECHDC2,ZNF511,ST3GAL6,NMT2,AIFM2,NFE2L1,DEGS1,ATIC,FAM49A,SERPINE2,RNF44,GIPR,KCTD13,CLGN,PCCA,PSMD2,UBE2E2,TBC1D7,C5orf22,PMVK,MAF,SH3GLB1,NUDT14,EMC7,C1QB,KPNA1,FBXL14,CHST2,CXCL10,BCAT1,DYNLL1,ABR,CTSS,ABCC1,RPS2,TMEM9B,RIMS3,CSRP2,TSPAN33,PDE1C,PIP5K1C,YARS,IL10RA,ALDOA,AIDA,ITGA7,LCP2,SLC35A4,ALDH4A1,ATP5G1,CDK16,CTNNA1,ACSF2,PFKL,DCLK2,IGHG3,SRGAP1,CCL28,HLA-DRA,NACC1,SARS,YIPF2,PLOD3,RPS19,C9orf142,EPB41L4B,URB1,ATXN2L,CCDC30,STXBP6,NR2C2AP,POMGNT1,ITGB2,MCF2L,FTL,COL5A3,UQCR10,PIGK,P2RY12,RUFY3,MAPRE3,MVD,GAB2,DYNLT1,CYBB,KPNA2,SIAH2,CLCN3,TENM2,APITD1/APITD1-CORT,PTX3,SPP1,SGCG,GPS2,ANLN,PSMC4,UQCR11,MARS,UBE2D2,MPP3,IL1RN,HSPA13,UBE2J2,SPX,LEP,STMN2,CD2,NLGN1,PRDX5,PDGFA,ERN1,FAM47E,GANAB,RRP36,RAMP2,SLFN5,FLNA,SENP3,CCDC73,SLC40A1,S100A8,RBM18,BHMT2,NLRC4,RAB8B,FRMD1,ADCY2,DLGAP4,MRC2,DCTPP1,AP3D1,F13A1,MKNK2,CSF1R,KCNQ4,TRPM6,ENO1,DYM,TANGO2,PANK3,UBA1,P2RX7,CARM1,ATP6V1B2,SHMT2,RPE,AGER,PIK3R1,NPAS2,POLRMT,PPP1R14B,SPRY4,BTBD11,ALPK3,CCND3,ATG9A,EIF3B,C6orf136,ARHGEF26,PLXNB2,KNSTRN,AIF1,RPA4,SLC2A5,YWHAG,SURF1,IRF5,CTSB,C15orf39,PLTP,FTH1,EPHX1,CD163L1,EVA1B,ARPC1B,PSMD7,DAPK2,DPM2,COL15A1,AAK1,UCP2,TUBB4B,FCGR2A,SLC25A1,ENG,MAGEC3,CSTB,MYO5A,MAZ,SOX9,STK31,DCX,PRKACB,SOCS3,NACAD,YWHAH,SEPT9,CCT2,CSNK1A1,FCER1A,AP1B1,DENND1C,CTSD,OSCP1,CCT5,ADAMTS5,C12orf49,STXBP1,STK39,UROS,ASNA1,MAPK8IP2,RIMS4,CREG1,FYB,TXNRD1,SLC7A2,TNS1,HSPB1,IGFBP4,F2RL3,DNASE1L3,PLGRKT,BARD1,ZNF219,ALAS1,PHLDB2,COL6A6,FARSB,HLA-G,ALDH2,EDN1,GTPBP2,RPL18A,STAT1,MT-CO1,THBS4,TRIM55,IPO4,G6PD,TSN,APOLD1,THEMIS2,CPAMD8,ARPC5,RAN,GHITM,DDX20,MKI67,GSS,EEF1D,AHSA1,LGMN,MPV17L2,MKX,POU6F2,KIF21A,MGAT4B,SYT2,AFAP1,TESK1,SFRP4,CAPN6,CPNE4,CKAP2,BCAP29,TSR3,NGRN,SPON2,FARSA,SYTL1,MNT,PRELID1,KIAA0408,RTN4,ME2,KRTAP4-4,B3GNT5,GSTP1,BTG3,SLC1A3,HYOU1,GPC4,RCOR2,MRPL39,ENAH,RPUSD3,LYZ,CES1,JUN,PGAM1,LRRC69,TRIM16,MT-CO3,MYO1D,XPO4,ZFAND2B,PLXNA1,NOL6,PTPRK,KRT6B,CSRNP2,LRRC8D,PLA2G2A,HIST1H1B,SNTG2,PI3,HIST1H1E,GLIS2,SLC48A1,RHBDD2,BRINP2,TREM2,USP22,MMS19,PDZD4,PER1,TMEM106A,PLCB2,PFN1,HIST1H2BC,C8orf82,KCND3,ARF1,PRMT3,CD4,MYH15,UNC5B,MAP1B,PPP1R18,TCEB2,TRIM31,CD63,GSPT1,CAMK2D,SLC25A6,ALDH3A2,POMP,HIST1H3J,ANXA7,GPC1,PHPT1,RILP,HIST1H4H,RET,MDH2,BCKDK,C7orf50,MFSD3,HK1,SHOC2,FUCA1,PRKRA,TRIOBP,PACSIN3,GSDMB,XYLT1,TALDO1,HSPA9,RAC1,CPVL,GPAA1,RASD1,EVI2B,SH2B3,MAPT,TMEM176A,FMN2,RARRES3,CD14,CLCN7,LFNG,RPS15A,ARL2,SPIRE1,SRM,COPS4,SPRED1,CNRIP1,SH3RF3,TOLLIP,KIAA1191,ATF5,MRPS30,CD83,RRAGD,OAZ1,SOX18,KCTD1,MAPKAPK2,ATP5I,MLH3,ADAMTS15,SCN2A,COL5A2,BHLHE41,HSPH1,OAF,VSIG4,KCNJ3,MRPS16,PLXND1,KIAA1683,PLBD2,TMEM2,APOC1,EPHB3,GBE1,SLC1A2,PDE8B,C6,SEMA4B,DHRS7B,KLHDC8B,NDUFA9,KDM6B,WHSC1,CTSG,COL8A1,PCIF1,C1QC,PLEKHM2,SLC9A1,CLIP1,FADS3,PTPRC,KEAP1,FRAS1,ST6GALNAC2,ATF4,LMX1A,UNG,TP53,ATP5J,LCP1,RHEB,PROSC,BCOR,KCTD16,PPP1R1B,TMEM201,PPTC7,FGFR2,TIMM8B,FLOT1,RHBDD1,DSG1,HSPA8,TMEM127,CTSA,FBXW5,UCK1,MARCH4,TULP3,TMEM33,LYPLA1,STEAP3,PPDPF,CHCHD10,FGF2,OSGIN1,PHLDA2,HSPB8,CKAP4,ZNF827,CD74,SLC35B2,LAMP3,C1QTNF9,COL16A1,SHTN1,SORBS1,OSBPL11,TTC23,FCGR3A/FCGR3B,G3BP2,TMC2,WDR36,SRA1,TRIB3,SPTLC3,HSPA2,FOS,MT-ND1,NR4A2,MOBP,ALDH1L2,FLNC,FAM129A,PPT1,MBD3,USP46,TSC22D2,TTYH3,SEMA3C,ABCC3,CSTF3,PTER,ABCB6,KCTD2,SESN2,ATP2B1,MBP,OGFOD1,STARD7,HSPA5,ZNRF3,RHOG,ENTPD5,ELP5,CDC42EP1,GCLM,CHMP1A,C17orf53,LACTB,TOP3B,PCSK6,MFSD14A,SRPRB,HNRNPAB,CAPG,CITED1,KLF4,SLC25A44,DMXL2,SLC3A2,KCNG1,ALG3,PPA2,SLC25A39,CDH20,NDUFA6,CAPN2,MRPS2,PIK3AP1,MEGF8,DOK5,ATP6V0C,UBXN1,SYCE1,MSR1,DMD,IL17RA,PDGFC,HNRNPK,SLC19A3,CSRP2BP,PREPL,PPP1R2,SAA1,TRABD2A,RNH1,STOX1,TOX2,MCRS1,LONP1,KRT14,PSAT1,MT-ND6,CAPZB,SLC9A3R1,ZNF358,NPY1R,TUBG1,PWWP2B,NQO1,HPS1,TRPA1,LARP6,NRBF2,GIT1,FGF1,ANGPTL5,SHB,CIDEA,LGALS2,KIF5B,TTL,EIF3I,GZF1,GXYLT2,SLC29A4,CADM3,APOB,ITSN1,C9orf72,AHCYL1,SH3BGRL3,HRAS,NCSTN,MT-CO2,CECR1,DGCR6L,PEG10,FAM91A1,GAA,PIK3CG,TXN,KIF5C,ANAPC11,EYA2,WNT5B,CFL1,THSD4,SLC24A3,TUBB2A,AASS,CTPS1,ANGPTL1,CCND2,NR1D1,CD68,CNTNAP4,STIP1,MBD4,ZNF672,ORC5,GLUL,RAMP3,SFRP1,TCF7,CYR61,MYEOV,C3AR1,RORB,ENOPH1,S100A11,HIST1H1C,MSC,SLC24A2,RAB32,ADAM17,RPS3A,ZNF330,TCEA1,MS4A6A,SRD5A1,UBQLN1,DUSP6,XPOT,TTC1,SLBP,PIP,FANCE,UCHL1,SEC61A1,HLCS,TOP2A,SNX10,ACAP2,SLC19A1,PSMD14,STIM1,TPO,TP53RK,AMFR,PI4KA,LETM1,ADRM1,TYROBP,TBC1D9,MT-ND4,KRT5,AREL1,APP,EIF3G,FIS1,SUPV3L1,PDIA6,SREBF2,ADCY1,MS4A2,NR5A2,DVL3,CBX4,ACTR1A,EFR3A,SLC7A11,XPO5,UTP4,MMRN1,SDC4,TAF10,TUBB,UBA2,CHST15,CTBP1,RAB11FIP2,ITGAV,NEO1,SLC7A5,RFLNB,EIF2AK1,MIF,C6orf132,BMP2K,SNRPF,RAB10,SIPA1L1,PKN1,EPRS,LMCD1,SEL1L,EFS,ADCYAP1R1,ACKR3,CNPY3,GNL3,VDAC1,JTB,RNF165,EPB41L3,CUTA,VAPA,PKM,SLC7A1,SMPD1,LDLRAD3,HIF1A,NAA10,FAS,SEPHS2,HMOX1,RNF167,PCK2,NDUFC2,KCNMA1,ANXA1,VCP,TGFB2,POLN,KIT,ARHGEF2,SELENOH,NR2F6,ALPL,STK40,HMGCS1,ACTN1,PRNP,NACA,CD160,COPS7A,MTMR14,NXPH4,QSOX1,MAPK9,SLC5A3,KIAA0930,WARS,MT-ND5,CLDN1,ZNF117,MAT2A,RTN3	1154	
Immunological Disease	delayed hypersensitive reaction	delayed hypersensitive reaction	7.57E-06	 	1.914	bias	0.642	SRM,APOE,LAPTM5,AGER,CD2,GARS,CD83,CD74,H2AFZ,S100A7,CXCL10,CD28,PIK3CG,ALDH3A2,ANXA1,TP53,CCR1,MIF,SPP1,NPY1R,SOD1,IL20RB,S100A2,PI3,ITGB2,LGALS2,FCER1G,ALCAM	28	
Cell-To-Cell Signaling and Interaction	response	response of antigen presenting cells	7.79E-06	Increased	4.328	bias	2.340	GAB2,SOCS3,AGER,ERN1,CD74,BIN1,FAS,IRAK1,PTPRC,HMOX1,PARK7,PTPRJ,THBS1,CTSS,ANXA1,PIK3CG,SAA1,MAPKAPK2,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,CMC2,SPON2,APP,ISG15,ITGB2,CD68,TREM2,FCER1G,IL10RA,CD14,RARRES3,SIRPA,P2RX7	38	
Cell Death and Survival	cell death	cell death of endothelial cells	8.18E-06	 	0.891	 	0.925	ICMT,ADAM17,TGFBR1,LEP,ITSN1,AGER,DDIT3,PSMB10,ERN1,FGF2,ASS1,DUSP6,ADIPOQ,PPIA,HRAS,SMPD1,TYMP,CD74,HSPA5,FAS,HMOX1,ALDH2,EDN1,THBS1,S100A8,TXN,MAPKAPK2,NFE2L2,TP53,MIF,SPP1,UCP2,TNFRSF10B,RAC1,MAPK9,APP,FGF1,CYCS,VDAC1	39	
Cellular Assembly and Organization	stabilization	stabilization of filaments	8.19E-06	 	1.256	 	1.075	TP53,CRYAB,BMP2K,CFL1,STMN2,ERN1,PIK3R1,MBP,DVL1,MAP1B,NQO1,PKM,DYNLT1,CSF1R,CLIP1,APP,DCLK2,KIFC3,FLNA,MAPT,LOC102724428/SIK1,ARHGEF2,DCX,MAPRE3	24	
Cellular Function and Maintenance	function	function of antigen presenting cells	8.74E-06	 	 	 	 	APOE,GADD45B,MSR1,GDF15,UNC5B,FCER1A,PPIA,CD74,IRAK1,CXCL10,LGMN,CTSS,PIK3CG,TGFB2,CYBB,IFI30,CLCN3,STAT1,NLRC4,CCR1,PLXNA1,SIGMAR1,CD209,LCP1,IL2RG,SPP1,UCP2,TYROBP,NPY1R,FCGR2A,EGR1,MAPK9,CAPG,CSF1R,GRN,FOS,TREM2,FCER1G,CNPY3,CD14,PSAP,DUSP4,SIRPA,P2RX7,HSPB1	45	
Cell Death and Survival	cell death	cell death of epithelial cells	8.82E-06	 	0.515	 	0.001	SOCS3,CRYAB,TGFBR1,CD4,PIK3R1,UNC5B,HRAS,TMBIM6,HSPA5,CXCL10,SGPL1,DYNLL1,CTSS,ENTPD5,MCOLN3,ABCC1,ITGAV,TP53,HK1,SPP1,TNFRSF10B,RAC1,SDHC,IRF5,HAX1,IL1RN,MAPT,CTSB,GAPDH,INSR,SFRP1,VDAC1,ESR2,HSPB1,CD151,SCD,LEP,GADD45B,DDIT3,FGF2,ERN1,GDF15,HSPB8,ADIPOQ,CTNNA1,SMPD1,FAS,HMOX1,ALDH2,CA3,JUN,EDN1,TIMP1,SAA1,AAK1,DAB2,STAT1,MAPKAPK2,NDUFAB1,NFE2L2,ATP13A2,NLRC4,PRNP,EGR1,MAPK9,ENG,TRIB3,SOD1,CSF1R,FGF1,APP,RBCK1,FOS,MYOC,GLIS2,NTRK3,PEA15,NR4A1,FKBP4,CYCS,SLC25A5,P2RX7	82	
Neurological Disease, Organismal Injury and Abnormalities	gliosis	gliosis of cerebral cortex	9.04E-06	 	-0.245	 	0.111	APOE,MAPT,PPT1,ADIPOQ,CLCN7,ATP13A2,PRNP,APP,CERS2	9	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	cellular infiltration of phagocytes	9.12E-06	 	-0.259	 	-1.399	APOE,ADAM17,LEP,AGER,UNC5B,ADIPOQ,PPIA,HRAS,HIF1A,IL17RA,CXCL10,HMOX1,CES1,GBA,EDN1,ANXA1,DUSP10,PIK3CG,SAA1,CYBB,NFE2L2,TP53,CCR1,PTX3,MIF,SPP1,NQO1,CSF1R,NINJ1,APP,ITGB2,GLIS2,IL1RN,PLTP,C6,CYR61,P2RX7	37	
Neurological Disease	seizure disorder	seizure disorder	9.30E-06	 	-1.648	bias	0.796	SOCS3,MT-TT,NCDN,SNTA1,MAP1B,CA5B,C1QA,C1QB,TUBB,SLC9A1,PTPRC,CTSD,SRPX2,GLB1,ABCC1,STAM,CLCN3,STXBP1,ACP2,PPP1R1B,RAC1,LMCD1,HSPA8,FOSB,SLC25A22,IL1RN,MS4A4A,MAPT,MAPK10,CTSB,ME2,ATOX1,AARS,CYR61,MT-TL1,MT-TP,EPHX1,APOE,PIM3,LEP,GADD45B,FGF2,DUSP6,PCDH19,HYOU1,SLC1A3,ADIPOQ,HEXA,CD83,CA3,HMOX1,JUN,GBA,PPP1R9B,KCNMA1,LOC102724428/SIK1,ALPL,ALDH5A1,NDUFS4,CCR1,SIGMAR1,SCN2A,EGR1,SLC12A2,ANOS1,CSTB,KCNQ4,APP,SERPINE2,FOS,MT-ND5,RNF144A,PPT1,NR4A1,TSPO,TPP1,PSAP,SLC1A2,DCX,ADRA1A,NCAM1	81	
Cell Signaling	activation	activation of enzyme	9.69E-06	Increased	3.018	bias	 	PLCB2,SLC31A1,TGFBR1,ARF1,CD4,LHCGR,FCER1A,NCSTN,SDC4,UBA2,PTPRC,PLCE1,SAE1,PIK3CG,RET,NSMAF,PRKRA,PKN1,HSPA8,CTSA,ERP29,ADCYAP1R1,MAPK10,NAGLU,INSR,CYR61,JTB,GSTP1,HSPB1,GADD45B,ERN1,FGF2,ADIPOQ,CD74,PLPP1,PARK7,EDN1,THBS1,SAA1,VCP,KIT,DAB2,S100A8,STAT1,ADORA1,FAM162A,NLRC4,ADCY2,DAP,DVL1,MAPK9,TRIB3,SOD1,SHB,GIPR,NR4A2,NTRK3,RPS27L,ADCY1,APOC1,MS4A2,PSAP,CYCS,P2RX7,ADRA1A	65	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of sphingolipid	9.89E-06	 	-0.585	 	-0.522	CERS6,TP53,GM2A,HEXA,SMPD1,ARSA,FAS,APP,GBA,GLB1,PSAP,GULP1,NPC2	13	
Cell Morphology, Cellular Function and Maintenance	autophagy	autophagy of cells	1.04E-05	Increased	2.044	 	1.070	PAFAH1B2,SCD,ICMT,SDHB,DDIT3,AGER,DAPK2,ERN1,SESN2,CD4,PIK3R1,PKM,HSPB8,ADIPOQ,FKBP1A,SH3GLB1,SMPD1,HIF1A,HSPA5,FAS,HMOX1,PLCE1,GBA,GAA,NUPR1,ATF4,STIM1,NACC1,KIF5C,STAT1,NFE2L2,NLRC4,TBC1D10C,PRNP,TP53,LETM1,TBC1D9,TNFRSF10B,NQO1,RAB7A,QSOX1,TRIB3,ENG,SOD1,CISD2,POLDIP2,APP,CISD1,CAPNS1,TBC1D7,SQSTM1	51	
Cell Death and Survival	cell death	cell death of phagocytes	1.04E-05	 	-0.014	 	-0.272	APOE,ADAM17,LEP,DDIT3,MSR1,RAN,FCER1A,SMPD1,C1QA,HIF1A,PDGFC,FAS,IRAK1,HMOX1,LYZ,ANXA1,CYBB,S100A8,STAT1,HCAR2,NFE2L2,NLRC4,TP53,MIF,MAPK9,IRF5,TPSAB1/TPSB2,ISG15,APP,FOS,ITGB2,IL1RN,FCER1G,NR4A1,MS4A2,CTSB,CD14,PIK3AP1,C3AR1,P2RX7	40	
Cellular Movement	migration	migration of connective tissue cells	1.07E-05	 	0.489	bias	-1.215	RAP2A,APOE,TGFBR1,SLC4A2,LEP,AGER,FGF2,SNX17,ADIPOQ,SDC4,RAMP2,CXCL10,SGPL1,EDN1,THBS1,KCNMA1,CYGB,MAPKAPK2,TP53,MIF,DPT,SPP1,MRC2,GNA12,TMEM201,RAC1,DMTN,ENG,CSF1R,FGF1,CXCL16,CAPNS1,ARHGAP35,RAMP3,CYR61,TNS1	36	
Cell Death and Survival	cell death	cell death of fibroblast cell lines	1.07E-05	 	1.186	 	0.164	ITSN1,PIK3R1,UNC5B,HRAS,SDC4,HSPA5,SLC9A1,GLO1,SGPL1,CTSD,RHOG,EIF3B,ENTPD5,ABCC1,NUPR1,ATF4,TXN,DPM3,TP53,SFT2D2,EIF2AK1,PRKRA,RHEB,SPP1,TNFRSF10B,BCL2L14,GNG2,RAC1,IRF5,MNT,ADAM12,MAPT,RTN4,CTSB,DUSP4,INSR,CYR61,GSTP1,FTH1,EPHX1,GADD45B,DDIT3,CD2,SMPD1,HIF1A,FAS,HMOX1,CA3,HINT1,JUN,PARK7,VCP,TOP2A,OAZ1,STAT1,NFE2L2,PRNP,TMEM123,EGR1,LZTS2,MAPK9,CSF1R,APP,ENO1,LAMP2,CAPNS1,NR4A2,FKBP4,EIF3I,RPL37,UBA1,PPP2R1B	72	
Lipid Metabolism, Small Molecule Biochemistry	biosynthesis	biosynthesis of polyunsaturated fatty acids	1.10E-05	 	1.175	bias	-1.335	SCD,APOE,LEP,AGER,CD4,ADIPOQ,FCER1A,CD83,CD74,HMOX1,SGPL1,EDN1,ANXA1,ABCC1,HOXA10,KIT,GPC1,PRNP,TP53,ATP5J,CD209,MIF,FCGR2A,RAC1,ALOX5AP,MAPK9,SOD1,PLA2G2A,DEGS1,APP,PLAA,GIPR,IL1RN,FCER1G,MAPK10,CD14,AKR1B1,ESR2,CYP4A11,P2RX7,NPC2,NCAM1	42	
Lipid Metabolism, Small Molecule Biochemistry	storage	storage of triacylglycerol	1.10E-05	 	1.915	bias	1.079	SCD,APOE,PLIN1,LEP,PLIN2,SURF1,DGAT2,OSBPL11	8	
Organismal Injury and Abnormalities	damage	damage of epithelial tissue	1.12E-05	 	-0.415	 	-0.845	MIF,IL2RG,KRT6B,AGER,EGR1,RAC1,CTSG,RNASE1,SOD1,STARD7,GIT1,APP,PI3,PTPRJ,IL1RN,CLDN1,PIK3CG,NR4A1,IL10RA,ARHGDIA,TXN,MAPKAPK2,NFE2L2,CD151	24	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	efflux	efflux of sterol	1.12E-05	 	1.567	 	0.512	TP53,SCD,APOE,APOB,LEP,MSR1,AGER,GDF15,SNTB1,RAC1,ADIPOQ,HRAS,SLC25A1,SMPD1,IRAK1,APP,CES1,CTSS,SAA1,APOC1,S100A8,PLTP,HCAR2,NPC2	24	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of steroid	1.13E-05	Increased	2.007	bias	0.390	APOE,SCD,LEP,APOB,AGER,MSR1,GDF15,ADIPOQ,HRAS,SMPD1,IRAK1,CES1,CTSS,ABCC1,SAA1,S100A8,HCAR2,TP53,AKR1C1/AKR1C2,SLC9A3R1,SNTB1,RAC1,SLC25A1,APP,HSPA8,APOC1,TSPO,PLTP,ABCC3,EPHX1,NPC2	31	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	lung cancer	advanced stage lung cancer	1.13E-05	 	 	 	 	TP53,NDUFB4,TUBB4B,EPB41L4B,TUBG1,TUBB2A,PPIA,RNASE1,ATIC,FAS,FTL,KCNMA1,TOP2A,IFI30,TUBA1C,INSR,RET,TMSB10/TMSB4X,CLCN3,GSTP1,MYL12A	21	
Cell Death and Survival	apoptosis	apoptosis of colorectal cancer cell lines	1.14E-05	 	-1.368	 	-1.287	ADAM17,LEP,DDIT3,DAPK2,FGF2,GDF15,PKM,CSNK1A1,PPIA,HRAS,DTYMK,GLIPR1,FAS,CTBP1,HINT1,RABL6,AHSA1,G0S2,PARK7,EDN1,TIMP1,VCP,ITGAV,TMSB10/TMSB4X,STAT1,NAPA,NFE2L2,TP53,MIF,SPP1,PPP1R1B,TNFRSF10B,RAC1,MAPK9,CKAP2,IRF5,PDLIM4,NR4A2,NTRK3,USP22,CYCS,SOX9,SQSTM1,GSTP1	44	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of fatty acid	1.14E-05	 	1.557	bias	-0.727	SOCS3,APOB,AGER,CD4,FCER1A,SGPL1,ABCC1,HOXA10,TXN,GPC1,TP53,ATP5J,ACSL3,MIF,RAC1,PLAA,IL1RN,MAPK10,CD14,ME2,AKR1B1,CYP4A11,ESR2,APOE,SCD,LEP,PKM,ADIPOQ,SLC1A3,CD83,CD74,TECR,HMOX1,PARK7,EDN1,ANXA1,KIT,PRNP,CD209,FCGR2A,EGR1,MAPK9,ALOX5AP,TRIB3,SOD1,DEGS1,PLA2G2A,APP,MYO5A,GIPR,APOC1,FCER1G,P2RX7,NCAM1,NPC2	55	
Cellular Function and Maintenance, Small Molecule Biochemistry	homeostasis	homeostasis of ion	1.15E-05	 	1.086	 	1.293	APOE,SLC24A2,SLC31A1,LEP,AGER,ARF1,FGF2,SMPD1,HIF1A,HSPA5,SLC9A1,MAFG,CXCL10,HMOX1,CAMK2D,PLCE1,KCNMA1,STC2,ITGAV,NEO1,ANXA7,SLC40A1,SCNN1B,PRNP,TP53,CCR1,EIF2AK1,SIGMAR1,SFRP4,SPP1,SLC9A3R1,STK39,SLC24A3,SLC12A2,SLC39A6,STOML2,SOD1,APP,FTL,APLP2,SLC14A1,MAPT,EPHB3,COMMD1,FECH,ATOX1,AKR1B1,ATP6V1B2	48	
Cellular Assembly and Organization, Cellular Function and Maintenance	depolarization	depolarization of cellular membrane	1.16E-05	 	0.398	bias	-0.814	TP53,PEBP1,FHL1,ADIPOQ,PPIA,CSTB,FAS,APP,SHTN1,CAMK2D,JUN,PARK7,EDN1,ABCC1,CXCL14,SLC7A2,SLC1A2,ESR2,P2RX7,PRNP	20	
Cellular Movement, Connective Tissue Development and Function	cell movement	cell movement of fibroblasts	1.19E-05	 	0.184	bias	-1.483	RAP2A,APOE,TGFBR1,LEP,AGER,SNX17,FGF2,ADIPOQ,HRAS,SDC4,RAMP2,ENAH,CXCL10,SGPL1,JUN,EDN1,THBS1,CYGB,MAPKAPK2,TP53,DPT,SPP1,MRC2,GNA12,TMEM201,RAC1,DMTN,ENG,FGF1,FOS,CAPNS1,ARHGAP35,CAPN2,RAMP3,CYR61,TNS1	36	
Neurological Disease	neurodegeneration	neurodegeneration of central nervous system	1.19E-05	 	-1.480	bias	0.400	VAC14,ADIPOQ,SMPD1,GBA,GLB1,CYBB,NMNAT2,CLCN3,STAT1,UNG,NDUFS4,PRNP,SOD1,ARSA,NFE2L1,APP,MAPT,PPT1,CTSB,TPP1,NAGLU,PSAP,SLC1A2,CLCN7,SQSTM1	25	
Cellular Movement, Skeletal and Muscular System Development and Function	migration	migration of vascular smooth muscle cells	1.21E-05	 	-0.350	bias	-1.900	IGFBP4,FHL1,SPP1,LEP,AGER,FGF2,EGR1,NQO1,RAC1,PPIA,ALOX5AP,SDC4,RAMP2,GIT1,HMOX1,CAMK2D,TIMP1,THBS1,RTN4,NEO1,RAMP3,TXN,NFE2L2	23	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of sterol	1.28E-05	 	1.523	bias	0.311	TP53,APOE,SCD,LEP,APOB,SLC9A3R1,AGER,MSR1,SNTB1,GDF15,RAC1,ADIPOQ,HRAS,SMPD1,SLC25A1,IRAK1,APP,HSPA8,CES1,CTSS,SAA1,APOC1,TSPO,S100A8,PLTP,HCAR2,NPC2	27	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	chemotaxis	chemotaxis of neutrophils	1.35E-05	Increased	3.491	bias	 	DAPK2,CTSG,CD74,CXCL10,CD28,EDN1,PIK3CG,CXCL14,TGFB2,S100A8,STIM1,C1QBP,ADORA1,MAPKAPK2,TMSB10/TMSB4X,THBS4,SPP1,FCGR2A,RAC1,MAPK9,FLOT1,CAPG,TPSAB1/TPSB2,APP,GRN,ITGB2,MT-ND1,PREX1,PIP5K1C,FCER1G,NCKAP1L,C3AR1,CD151	33	
Cancer	transformation	cell transformation	1.36E-05	Increased	3.576	bias	0.902	PRKACB,ICMT,GAB2,TRAF3,ITSN1,SEPT9,CD4,PIK3R1,MAF,HRAS,DIRAS1,BIN1,EEF1D,ODC1,DYNLL1,RHOG,CCND3,PIK3CG,RET,TP53,MIF,SPP1,RAC1,TPM3,FGFR2,HMGA1,IRF5,SLC3A2,FOSB,MNT,SDCBP,CCND2,IL1RN,BTG2,MAPK10,SFRP1,CYR61,TMEM176B,ESR2,SIRPA,RPL41,FTH1,PEBP1,RPS3A,FGF2,PDGFA,BARD1,LGALS9,JUN,TGFB2,KIT,ASPH,MCRS1,FCGR3A/FCGR3B,ADCY2,EGR1,GNA12,DVL1,G6PD,LZTS2,MAPK9,KIFAP3,CSF1R,NDUFA13,ATIC,FGF1,FOS,MCF2L,NTRK3,SBF1,EIF3I,PRMT5,SOX9,DNPH1,EFEMP2,PPP2R1B	76	
Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	necrosis	necrosis of liver	1.36E-05	 	-0.859	 	0.115	SCD,APOE,SOCS3,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,FKBP1A,SMPD1,TMBIM6,IL17RA,FAS,PTPRC,CXCL10,SLC19A3,HMOX1,ALDH2,JUN,TIMP1,FLNA,ENTPD5,SAA1,ITGAV,CFH,STAT1,NFE2L2,TP53,TYROBP,MAPK9,SOD1,IRF5,NFE2L1,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,CD14,DUSP4,SLC25A5	44	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Nervous System Development and Function	activation	activation of microglia	1.41E-05	 	0.729	 	-0.240	TP53,APOE,MIF,GJB6,TRAF3,ADIPOQ,ANXA2,SOD1,TNFRSF12A,APP,OSTM1,CXCL10,HMOX1,IL1RN,TREM2,PPT1,MAPT,CYBB,ITGAV,CLCN7,ADORA1,P2RX7,PRNP	23	
Connective Tissue Disorders, Immunological Disease, Inflammatory Disease, Inflammatory Response, Skeletal and Muscular Disorders	juvenile rheumatoid arthritis	juvenile rheumatoid arthritis	1.43E-05	 	 	 	 	APOE,GADD45B,HSPB8,TPGS2,CD83,CD74,IL17RA,HLA-G,PTPRC,DYNLL1,THBS1,HLA-DRA,S100A8,TXN,PRNP,RPL32,CCR1,MIF,IGKC,FOSB,FOS,NR4A2,IL1RN,NR4A1,SLC1A2,RPSA	26	
Cellular Assembly and Organization	formation	formation of cytoskeleton	1.45E-05	Increased	2.478	bias	0.468	PFN1,ARF1,PIK3R1,MAP1B,FCER1A,HRAS,SDC4,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,CNTNAP1,AIF1,TESK1,MIF,CFL1,MTSS1,GNG2,CARMIL1,RAC1,TPM3,MLST8,HAX1,LMCD1,MYL9,PREX1,ERP29,MAPT,C3AR1,SIRPA,ARL2,SLC4A2,LEP,STMN2,FGF2,DMD,PHLDB2,EDN1,SORBS1,THBS1,FLNA,TUB,DAB2,ARHGEF2,GNG5,ASAP3,ADORA1,AMOT,VCAM1,CAPZB,FCGR2A,GNA12,FGF1,APP,MCF2L,KCTD13,COL5A3,MYOC,CXXC5,FKBP4,NCKAP1L,DCX	65	
Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation	assembly	assembly of cells	1.53E-05	 	1.025	 	-0.368	HOXB5,TGFBR1,AGER,SEPT9,SDC4,PANX1,ODC1,SPRY4,CXCL10,PIK3CG,CYBB,ARHGEF26,GPC1,TP53,PFKFB3,YWHAG,STK39,PAQR3,RAC1,FGFR2,ANGPTL1,PDCL3,CTSB,CYR61,CD151,APOE,SPRED1,LEP,GBP1,ERN1,FGF2,PKM,ADIPOQ,PPIA,HIF1A,PDGFC,TNFRSF12A,HMOX1,JUN,EDN1,PTPRJ,THBS1,SAA1,TGFB2,KIT,DAB2,S100A8,STAT1,PLOD3,THBS4,VCAM1,EGR1,MESP1,G6PD,ENG,CSF1R,EDF1,FGF1,APP,GRN,NR4A1,BMPER	62	
Infectious Diseases	infection	Bacterial Infections	1.59E-05	 	-0.738	 	0.734	PLCB2,CD4,PIK3R1,CTSG,TLR8,FCER1A,NCSTN,C1QA,C1QB,CXCL9,CXCL10,POR,CD28,ITGAV,IFI30,CYBB,C1QBP,NSMAF,LCP1,MIF,IL2RG,SPP1,FGFR2,CAPG,IRF5,ADCYAP1R1,IL1RN,MAPT,CTSB,CD14,SIRPA,APOE,ADAM17,MSR1,GDF15,SMPD1,CD83,HIF1A,IRAK1,S100A7,HLA-G,LYZ,IGHG3,TIMP1,MT-CYB,TOP2A,KIT,STAT1,MAPKAPK2,FCGR3A/FCGR3B,NLRC4,CCR1,PSMB4,PLXNA1,CD209,SIGLEC1,UCP2,CD160,FCGR2A,VSIG4,ALOX5AP,PLA2G2A,APP,GRN,FOS,CXCL16,ITGB2,FCER1G,ADRA1A	69	
Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	autosomal dominant myopathy	autosomal dominant myopathy	1.60E-05	 	 	 	 	S100A11,CRYAB,COL5A2,CFL1,CSRP2,TUBB2A,MTMR14,RAB7A,GARS,HSPB8,ENG,HIF1A,SDC3,TAX1BP3,SDCBP,FLNC,IFI30,DAB2,STIM1,AARS,HSPB1	21	
Cellular Compromise, Cellular Function and Maintenance	endoplasmic reticulum stress response	endoplasmic reticulum stress response	1.68E-05	 	-0.976	 	-1.238	DDIT3,ERN1,PIK3R1,HYOU1,TMBIM6,HSPA5,UCHL1,HMOX1,CTSD,CTSS,STC2,DNAJC4,GAA,VCP,ATF4,STIM1,NFE2L2,AMFR,TP53,HSPH1,SOD1,HSPA2,MAPT,DERL1,CTSB,CD14,AARS,SQSTM1	28	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of macrophages	1.69E-05	 	0.616	 	-0.282	CCR1,PTX3,APOE,MIF,SPP1,PFN1,FGF2,SOD1,FAS,FGF1,GRN,CD28,HMOX1,TIMP1,ACKR3,IL1RN,THBS1,NR4A1,C6	19	
Molecular Transport	release	release of metal	1.69E-05	 	1.909	bias	0.155	S100A11,FPR3,RAB32,LEP,DDIT3,AHCYL1,FGF2,CD4,SLC30A2,FKBP1A,TMBIM6,FAS,PTPRC,CD28,EDN1,ANXA1,PACS2,ITGAV,CYBB,SLC40A1,STIM1,ASPH,BCAP31,ADORA1,NFE2L2,PRNP,TP53,S100A1,CERS6,SPP1,LMO4,FCGR2A,DVL1,SOD1,CSF1R,APP,MYO5A,FCER1G,P2RY12,P2RX7	40	
Developmental Disorder, Neurological Disease, Organismal Injury and Abnormalities	complex cortical dysplasia with other brain malformations	complex cortical dysplasia with other brain malformations	1.74E-05	 	 	 	 	KIF2A,TUBG1,TUBB2A,KIF5C,TUBB	5	
Cell Morphology, Cellular Compromise	shrinkage	shrinkage of blood cells	1.74E-05	 	0.314	 	-0.189	CTSD,CD2,ANXA7,P2RX7,FAS	5	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	cell death	cell death of kidney cells	1.76E-05	 	-0.409	 	-1.538	GFPT1,CRYAB,CCNI,UNC5B,HRAS,HSPA5,SGPL1,RHOG,MCOLN3,ABCC1,ITGAV,NEO1,DPM3,TP53,HK1,SPP1,TNFRSF10B,GNG2,BCL2L14,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,SFRP1,VDAC1,GSTP1,HSPB1,APOE,CD2,DDIT3,ERN1,FGF2,HYOU1,HIF1A,FAS,EDN1,VCP,AAK1,ADORA1,NDUFAB1,NFE2L2,ATP13A2,NLRC4,TMEM123,PRNP,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,GLIS2,NTRK3,SREBF2,PEA15,CYCS,P2RX7	60	
Cell Death and Survival	cell death	cell death of immune cells	1.85E-05	 	1.051	 	0.356	APOB,AGER,PIK3R1,RAN,SH3GLB1,HRAS,C1QA,CXCL10,PTPRC,PIK3CG,ABCC1,STAM,EYA2,ZBTB16,TP53,YWHAG,LAIR1,STOML2,IRF5,HAX1,MNT,CCND2,PRELID1,CTSB,GAPDH,DUSP4,TCF7,C3AR1,FTH1,HIST1H1C,APOE,NME1,ADAM17,GADD45B,DDIT3,FGF2,DAPK2,LGALS9,CD74,PIP,OGT,LYZ,JUN,TOP2A,HCAR2,NFE2L2,FCGR3A/FCGR3B,TYROBP,EGR1,APP,ISG15,ITGB2,FOS,MS4A2,NR4A1,FCER1G,GAB2,TRAF3,CD4,FCER1A,CSNK1A1,TUBB,CD28,CTSD,PLCE1,COMT,CYBB,HK1,IL2RG,MIF,SPP1,RAC1,KLF4,TPSAB1/TPSB2,PKN1,IL1RN,CD14,PIK3AP1,SIRPA,LEP,MSR1,CD2,ERN1,SMPD1,HIF1A,PDGFC,FAS,IRAK1,HLA-G,HMOX1,THBS1,TIMP1,ANXA1,TGFB2,KIT,S100A8,STAT1,NLRC4,NQO1,MAPK9,KIFAP3,CSF1R,LGALS2,P2RX7	104	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of glycolipid	1.86E-05	Increased	2.904	bias	1.154	SCD,LEP,FGF2,DPM2,ADIPOQ,ST6GALNAC4,HEXA,SMPD1,FAS,CERS2,SGPL1,GBA,GLB1,ABCC1,KIT,DPM3,NSMAF,ALDH5A1,CERS6,GM2A,ST3GAL6,ARSA,GPAA1,DEGS1,APP,MPDU1,MAPK10,PSAP,B3GNT5,P2RX7	30	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response	aggregation	aggregation of blood platelets	1.88E-05	 	1.364	 	0.409	PLCB2,SLC7A11,LEP,F2RL3,AGER,PIK3R1,GDF15,ADIPOQ,CTSG,CD63,CES1,RHOG,TIMP1,THBS1,FLNA,PIK3CG,ITGAV,LAMP1,DAB2,ANXA7,CFH,MYL12A,STXBP1,FCGR2A,DMTN,APP,SERPINE2,MYL9,PIP5K1C,FCER1G,P2RY12,PLEK,AKR1B1,ACTG1,LCP2,HSPB1,CD151	37	
Energy Production, Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry	concentration	concentration of ATP	1.88E-05	 	1.220	 	0.105	ATP5G1,PLCB2,LEP,UBQLN1,PKM,HIF1A,FAS,NFE2L2,TP53,S100A1,MT-ATP6,UCP2,LETM1,NQO1,STOML2,APP,ENO1,SOX6,SREBF2,MAPT,ALDOA,GAPDH,SQSTM1,VDAC1,ESR2,P2RX7	26	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	migration of myeloid cells	1.89E-05	Increased	2.223	bias	0.123	ADAM17,PLCB2,LEP,AGER,PIK3R1,GDF15,CXCL9,IL17RA,FAS,CXCL10,HMOX1,ANXA1,PIK3CG,SAA1,ITGAV,CYBB,NEO1,S100A8,TXN,ADORA1,MAPKAPK2,PRNP,CCR1,VCAM1,SPP1,RAC1,ENG,NINJ1,SPON2,ITGB2,PREX1,RTN4,SIRPA	33	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	recruitment	recruitment of macrophages	1.92E-05	 	0.999	bias	-0.493	CCR1,APOE,GAB2,VCAM1,CRYAB,UCP2,APOB,SPP1,PLGRKT,ADIPOQ,CD74,CSF1R,APP,CXCL10,ITGB2,THBS1,IL1RN,ANXA1,PIK3CG,CYR61,NFE2L2,HCAR2,C3AR1	23	
Cancer, Gastrointestinal Disease, Hereditary Disorder, Organismal Injury and Abnormalities	familial colorectal cancer	familial colorectal cancer	1.94E-05	 	 	 	 	TP53,MT-CO1,MT-CYB,TRIM28,MT-CO2,MT-ND4L,PLA2G2A,MLH3	8	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	necrosis	necrosis of kidney	2.01E-05	 	-0.735	 	-1.601	GFPT1,CRYAB,CCNI,UNC5B,HRAS,HSPA5,APRT,SGPL1,RHOG,MCOLN3,ABCC1,ITGAV,NEO1,DPM3,TP53,HK1,SPP1,TNFRSF10B,GNG2,BCL2L14,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,SFRP1,VDAC1,GSTP1,HSPB1,APOE,CD2,DDIT3,ERN1,FGF2,HYOU1,HIF1A,FAS,HMOX1,EDN1,VCP,AAK1,ADORA1,NDUFAB1,NFE2L2,ATP13A2,NLRC4,TMEM123,PRNP,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,GLIS2,NTRK3,SREBF2,PEA15,CYCS,P2RX7	62	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	response	response of macrophages	2.04E-05	Increased	3.919	bias	2.253	GAB2,AGER,ERN1,BIN1,FAS,IRAK1,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,MAPKAPK2,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,CMC2,APP,SPON2,ISG15,ITGB2,TREM2,FCER1G,IL10RA,CD14,SIRPA,P2RX7	31	
Cell Death and Survival	cell death	cell death of macrophages	2.16E-05	 	0.667	 	0.067	APOE,DDIT3,MSR1,RAN,C1QA,HIF1A,PDGFC,FAS,IRAK1,HMOX1,LYZ,STAT1,NFE2L2,NLRC4,TP53,MIF,MAPK9,ISG15,APP,FOS,NR4A1,CTSB,CD14,PIK3AP1,C3AR1,P2RX7	26	
Dermatological Diseases and Conditions	plaque psoriasis	plaque psoriasis	2.16E-05	 	 	 	 	CSTA,CD2,CD4,MBP,ZNF91,CXCL9,CXCL10,S100A7,HMOX1,JUN,CYP3A5,ABCC1,S100A8,STAT1,GJB2,KRT10,KRT14,KRT6B,PI3,FOS,PSAP,GAPDH,KRT6A,ARHGDIA,CST6,GSTP1	26	
Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Inflammatory Response	phagocytosis	phagocytosis of cells	2.21E-05	Increased	4.635	bias	1.900	GAB2,PFN1,AGER,CD4,C1QA,BIN1,CLIP1,CXCL10,PTPRC,RHOG,ABR,ITGAV,CLCN3,GULP1,PTX3,EIF2AK1,TP53,MIF,RAC1,CAPG,HSPA8,PIP5K1C,CD14,SIRPA,LEP,MSR1,ADIPOQ,SMPD1,FAS,HMOX1,PTPRJ,THBS1,SAA1,ANXA5,ANXA1,TUB,STIM1,MAPKAPK2,ADORA1,FCGR3A/FCGR3B,SIGLEC1,UCP2,FCGR2A,ISG15,APP,ITGB2,TREM2,FCER1G,P2RX7	49	
Cardiovascular System Development and Function, Tissue Development	development	development of endothelial tissue	2.30E-05	 	0.741	 	-0.605	HOXB5,TGFBR1,AGER,SEPT9,SDC4,ODC1,SPRY4,CXCL10,PIK3CG,CYBB,ARHGEF26,GPC1,TP53,PFKFB3,SPP1,YWHAG,STK39,PAQR3,RAC1,FGFR2,ANGPTL1,PDCL3,CTSB,CYR61,CD151,APOE,SPRED1,LEP,GBP1,ERN1,FGF2,PKM,ADIPOQ,PPIA,HIF1A,PDGFC,TNFRSF12A,HMOX1,JUN,EDN1,PTPRJ,THBS1,SAA1,TGFB2,KIT,DAB2,S100A8,STAT1,PLOD3,THBS4,VCAM1,EGR1,MESP1,G6PD,ENG,CSF1R,EDF1,FGF1,APP,GRN,NR4A1,BMPER	62	
Cell Death and Survival	necrosis	necrosis of vascular endothelial cells	2.35E-05	 	1.814	 	1.702	TP53,TGFBR1,UCP2,SPP1,LEP,ITSN1,DDIT3,FGF2,ERN1,DUSP6,TNFRSF10B,ADIPOQ,MAPK9,HSPA5,FAS,FGF1,APP,ALDH2,HMOX1,THBS1,CYCS,S100A8,VDAC1,NFE2L2	24	
Cardiovascular System Development and Function, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Organismal Development, Tissue Development	development	endothelial cell development	2.39E-05	 	0.872	 	-0.480	HOXB5,TGFBR1,AGER,SEPT9,SDC4,ODC1,SPRY4,CXCL10,PIK3CG,CYBB,ARHGEF26,GPC1,TP53,PFKFB3,YWHAG,STK39,PAQR3,RAC1,FGFR2,ANGPTL1,PDCL3,CTSB,CYR61,CD151,APOE,SPRED1,LEP,GBP1,ERN1,FGF2,PKM,ADIPOQ,PPIA,HIF1A,PDGFC,TNFRSF12A,HMOX1,JUN,EDN1,PTPRJ,THBS1,SAA1,TGFB2,KIT,DAB2,S100A8,STAT1,PLOD3,THBS4,VCAM1,EGR1,MESP1,G6PD,ENG,CSF1R,EDF1,APP,FGF1,GRN,NR4A1,BMPER	61	
Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders	high bone mass disease	high bone mass disease	2.41E-05	 	-1.905	bias	 	TP53,GAB2,SLC4A2,TYROBP,RAC1,CSF1R,PLEKHM1,OSTM1,FOS,JUN,VCP,FCER1G,SNX10,CLCN7,SQSTM1,ESR2,ALPL	17	
Cell Death and Survival	cell death	cell death of pheochromocytoma cell lines	2.42E-05	 	0.573	 	0.106	TP53,UCP2,FGF2,RAC1,G6PD,PPIA,MAPK9,TRIB3,SOD1,FAS,APP,DYNLL1,JUN,IL1RN,MAPT,BTG2,VCP,MAPK10,GAPDH,PSAP,CYCS,ADORA1,PPP2R1B,SIRPA,HSPB1	25	
Cell-To-Cell Signaling and Interaction	response	response of granulocytes	2.43E-05	Increased	2.708	bias	0.873	TP53,PTX3,VCAM1,AGER,TYROBP,FCGR2A,FCER1A,CTSG,FAS,CXCL10,ITGB2,IGHG3,THBS1,TREM2,ANXA1,PIK3CG,SAA1,FCER1G,STIM1,IGHA1,CLCN3,FCGR3A/FCGR3B	22	
Cellular Assembly and Organization	formation	formation of vacuole	2.46E-05	 	-0.147	 	-0.386	MIF,GJB6,RAB7A,TYMP,SOD1,FAS,APP,CTSD,LAMP2,ATG9A,EMC6,ANXA1,VCP,PACS2,LAMP1,HLTF,NDUFS4,TBC1D10C	18	
Tissue Development	growth	growth of connective tissue	2.55E-05	 	0.959	 	-1.178	AGER,ITSN1,PIK3R1,NCSTN,HRAS,MKI67,PTPRC,SGPL1,CCND3,ATF4,AIF1,TXN,WNT5B,TP53,RHEB,PAQR3,TNFRSF10B,TPM3,FGFR2,ANXA2,HMGA1,CCND2,NPR3,IL10RA,CTSB,DUSP4,SFRP1,CYR61,ESR2,GSTP1,FTH1,S100A11,FGF2,ADIPOQ,CD74,ATRAID,OGT,JUN,NFE2L2,KRT10,NDUFS4,PTPRK,TYROBP,ENG,GRN,MCF2L,FOS,NTRK3,TREM2,SOCS3,ICMT,TRAF3,SLC7A11,CSNK1A1,SDC4,CD28,HS6ST1,CTSD,PLCE1,HOXA10,NUPR1,ITGAV,IFI30,RET,MIF,SPP1,RAC1,KLF4,RASD1,SLC3A2,FOSB,TLN2,GNL3,INSR,HSPB1,IGFBP4,LEP,PDGFA,CD83,SMPD1,HIF1A,PDGFC,FAS,HDGF,TNFRSF12A,HMOX1,HINT1,EDN1,KCNMA1,TIMP1,SAA1,TGFB2,KIT,STAT1,MAPKAPK2,MAPK9,EMD,SOD1,CSF1R,ATIC,FGF1,CAPNS1	102	
Cellular Assembly and Organization, Cellular Function and Maintenance	stabilization	stabilization of microtubules	2.62E-05	 	0.889	 	1.019	TP53,CRYAB,BMP2K,STMN2,ERN1,PIK3R1,MBP,DVL1,MAP1B,NQO1,PKM,CSF1R,CLIP1,APP,DCLK2,KIFC3,MAPT,LOC102724428/SIK1,ARHGEF2,DCX,MAPRE3	21	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response	cellular infiltration	infiltration by neutrophils	2.62E-05	 	-0.113	 	-0.867	SOCS3,APOE,ADAM17,PLCB2,UNC5B,CTSG,ADIPOQ,IL17RA,FAS,CXCL10,HMOX1,RSPO3,TIMP1,ANXA1,PIK3CG,STIM1,CFH,GJB2,TP53,PTX3,SPP1,NQO1,ALOX5AP,ITGB2,PREX1,IL1RN,FCER1G,CTSB,CD14,SFRP1,PLTP,C3AR1,HSPB1	33	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	migration of antigen presenting cells	2.62E-05	Increased	2.835	bias	0.989	APOE,ADIPOQ,HIF1A,CD74,CXCL9,CXCL10,NARS,TIMP1,FLNA,PIK3CG,ABCC1,ITGAV,CYBB,KIT,STAB1,MAPKAPK2,NLRC4,PRNP,CD209,MIF,SPP1,TYROBP,RAC1,ENG,PLXND1,CSF1R,NINJ1,IL1RN,TREM2,SH2B3,IL10RA,ALCAM,SIRPA	33	
Cancer, Organismal Injury and Abnormalities	cancer	stage 3 cancer	2.66E-05	 	 	 	 	NME1,LHCGR,NME2,FKBP1A,HMOX1,JUN,LOC102724428/SIK1,KIT,TUBA1C,RET,GJB2,KRT14,IL2RG,SPP1,SLC9A3R1,TUBB4B,TUBG1,TUBB2A,FGFR2,KRT5,ATIC,FIS1,C19orf53,PSMB2,PSMD2,INSR,AIDA,LYPLA1,CBX3,ESR2	30	
Neurological Disease, Organismal Injury and Abnormalities	neurodegeneration	neurodegeneration of brain	2.70E-05	 	-1.286	bias	0.526	VAC14,ADIPOQ,SMPD1,SOD1,ARSA,NFE2L1,APP,GBA,GLB1,PPT1,MAPT,CYBB,CTSB,TPP1,NAGLU,NMNAT2,PSAP,SLC1A2,CLCN7,STAT1,CLCN3,UNG,NDUFS4,PRNP	24	
Cancer, Organismal Injury and Abnormalities	carcinoma	advanced stage carcinoma	2.73E-05	 	 	 	 	SCD,IGFBP4,LHCGR,PPIA,FKBP1A,RNASE1,HIF1A,PLPP1,COL15A1,FAS,POR,KCNMA1,TOP2A,IFI30,KIT,DAB2,TUBA1C,CFH,RET,TMSB10/TMSB4X,CLCN3,MYL12A,TP53,IL2RG,NDUFB4,SPP1,TUBB4B,EPB41L4B,TUBG1,TUBB2A,FGFR2,CSF1R,ATIC,FTL,CXXC5,INSR,SFRP1,SEMA3C,TMEM176B,ESR2,GSTP1	41	
Skeletal and Muscular System Development and Function, Tissue Development	growth	growth of smooth muscle	2.74E-05	Increased	2.488	 	1.371	SOCS3,AGER,PIK3R1,CMA1,FCER1A,SLC9A1,CAMK2D,COMT,AIF1,TXN,TP53,MIF,SPP1,TNFRSF10B,RAC1,FGFR2,KLF4,NPR3,IL1RN,CAPN2,INSR,AKR1B1,C3AR1,ESR2,SIRPA,IGFBP4,APOE,FHL1,LEP,FGF2,ADIPOQ,PPIA,HIF1A,IRAK1,C1QTNF9,HMOX1,JUN,EDN1,THBS1,STIM1,STAT1,NFE2L2,EGR1,NQO1,ALOX5AP,CXCL16,FOS,NR4A2,NR4A1,SOX9	50	
Cell Death and Survival	cell death	cell death of blood cells	2.75E-05	 	0.723	 	0.299	APOB,AGER,PIK3R1,RAN,SH3GLB1,HRAS,C1QA,CXCL10,PTPRC,PIK3CG,ABCC1,STAM,EYA2,ZBTB16,TP53,YWHAG,LAIR1,STOML2,IRF5,HAX1,MNT,CCND2,PRELID1,CTSB,GAPDH,DUSP4,TCF7,C3AR1,FTH1,HIST1H1C,APOE,NME1,ADAM17,GADD45B,DDIT3,FGF2,DAPK2,LGALS9,PPIA,CD74,PIP,OGT,LYZ,JUN,TOP2A,HCAR2,NFE2L2,FCGR3A/FCGR3B,TYROBP,TRIM28,EGR1,APP,ISG15,AIP,ITGB2,FOS,MS4A2,NR4A1,FCER1G,GAB2,TRAF3,PFN1,CD4,FCER1A,CSNK1A1,TUBB,CD28,CTSD,PLCE1,COMT,CYBB,HK1,IL2RG,MIF,SPP1,RAC1,KLF4,TPSAB1/TPSB2,PKN1,IL1RN,CD14,PIK3AP1,SIRPA,LEP,MSR1,CD2,ERN1,SMPD1,HIF1A,PDGFC,FAS,IRAK1,HLA-G,HMOX1,THBS1,TIMP1,ANXA1,TGFB2,KIT,S100A8,STAT1,NLRC4,NQO1,MAPK9,KIFAP3,CSF1R,LGALS2,P2RX7	108	
Organismal Development	morphology	morphology of body cavity	2.75E-05	 	 	 	 	PLIN1,KDM6B,APOB,AGER,RRM2B,ITGA8,NCSTN,SLC35C1,HLA-DQB1,KPNA1,APRT,PTPRC,POR,LGMN,CCND3,ARID3B,GAA,PIK3CG,PLIN5,ATF4,UNG,TP53,RBM38,RHEB,MTSS1,CSRP2,MAD2L2,FGFR2,TSPAN33,HMGA1,ARHGDIB,SYTL1,CTSA,CCND2,ARHGAP35,B3GNT5,C3AR1,ESR2,STEAP3,LCP2,BANK1,APOE,HIST1H1C,ADAM17,SLC4A2,SRD5A1,FGF2,HS2ST1,GDF15,HSPB8,HLA-DQA1,ADIPOQ,FKBP1A,HEXA,PIP,CES1,JUN,GBA,PTPRJ,SLC19A1,DAB2,GNG5,SCNN1B,NFE2L2,KRT10,CCR1,KRT6B,IGKC,EGR1,MESP1,LZTS2,KRT5,COPS3,APP,GRN,FOS,ITGB2,LAMP2,GLIS2,NTRK3,SREBF2,PPT1,FCER1G,FKBP4,NR5A2,PSAP,ARHGDIA,DVL3,SOX9,BMPER,SOCS3,DAD1,ABCA3,CD4,LHCGR,SDC4,BIN1,CEBPG,CD28,CTSD,RSPO3,HS6ST1,PLCE1,COMT,ENTPD5,HOXA10,CYBB,ITGAV,NUPR1,HOXA7,ANXA7,RET,CLCN3,TOP3B,PTX3,EIF2AK1,MIF,IL2RG,SPP1,SGCG,PCSK6,MAPK8IP2,PHB2,KLF4,PREX1,ADAM12,ACKR3,IL1RN,SH2B3,FMN2,NAGLU,CAPN2,LFNG,H1F0,INSR,AKR1B1,MEGF8,TNS1,RPSA,CD151,IGFBP4,LEP,MSR1,PDGFA,SMPD1,HIF1A,RAMP2,FAS,CIAPIN1,HMOX1,SLC19A3,EDN1,THBS1,FLNA,TGFB2,CFH,STAT1,ALPL,VCAM1,CAPZB,SLC9A3R1,TRIM55,NPY1R,SLC12A2,MTMR14,NQO1,G6PD,EMD,MAPK9,SOD1,SNX27,KIFAP3,CSF1R,KIF3B,CISD2,PLXND1,NFE2L1,PCCA,EPHB3,GBE1,CPEB1,CARM1	182	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	non-small-cell lung carcinoma	advanced non-small-cell lung carcinoma	2.78E-05	 	 	 	 	TP53,NDUFB4,TUBB4B,EPB41L4B,TUBG1,TUBB2A,PPIA,RNASE1,ATIC,FAS,FTL,TOP2A,IFI30,TUBA1C,INSR,RET,CLCN3,TMSB10/TMSB4X,GSTP1,MYL12A	20	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of antigen presenting cells	2.78E-05	 	1.032	bias	-0.410	APOE,GAB2,CRYAB,APOB,LEP,PLGRKT,ADIPOQ,CD74,CXCL10,THBS1,PIK3CG,ANXA1,NFE2L2,HCAR2,CCR1,VCAM1,SPP1,UCP2,IRF5,CSF1R,APP,ITGB2,IL1RN,CYR61,C3AR1	25	
Cellular Assembly and Organization	transport	transport of vesicles	2.81E-05	 	1.029	bias	-0.391	SPIRE1,APOE,PCLO,ITSN1,SCAMP2,NLGN1,TOR1A,FGFR2,SYP,RAB9A,SNCG,SOD1,BIN1,ADGRL1,KIF3B,MYO5A,HSPA8,GRN,KIF5B,PIP5K1C,MAPT,PNKD,SYT2,INSR,SCAMP3,P2RX7	26	
Cell Death and Survival	removal	removal of cells	2.83E-05	 	0.630	bias	-0.944	TP53,PTX3,UCP2,LEP,FCGR2A,TRIM28,ADIPOQ,MAPK9,TPSAB1/TPSB2,SPON2,CD28,ZNRF3,CD68,IL1RN,FLNA,CXCL14,FCER1G,ITGAV,CD14,SIRPA,NLRC4,FCGR3A/FCGR3B	22	
Cellular Compromise	disassembly	disassembly of filaments	3.00E-05	Increased	2.044	 	1.645	APOE,CFL1,STMN2,EML4,DVL1,MAP1B,RAC1,HRAS,CKAP2,PLXND1,FAS,APP,KIF2A,CFL2,PDXP,ABCC1,MAPT,MAPK10,ARHGEF2,PLEK,INSR,PPP1CA,PRNP	23	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	efflux	efflux of cholesterol	3.00E-05	 	1.369	 	0.363	TP53,SCD,APOE,APOB,LEP,MSR1,AGER,GDF15,SNTB1,RAC1,ADIPOQ,HRAS,SLC25A1,IRAK1,APP,CES1,CTSS,SAA1,APOC1,S100A8,PLTP,HCAR2,NPC2	23	
Molecular Transport, Protein Trafficking	transport	transport of protein	3.03E-05	 	1.772	bias	0.112	AHCYL1,AKR1C3,YWHAH,SCAMP2,ARF1,MBP,MAP1B,NME2,XPO5,RAN,AP1B1,DYNLT1,KPNA1,SNX12,SCYL2,FRAS1,KPNA2,SEC61B,RILP,NAPA,VPS11,TP53,CFL1,TNPO1,HSPA9,PHB2,RAB10,HSPA8,CTSA,ERP29,MAPT,COMMD1,EIF5A,RAMP3,SQSTM1,XPO6,LEP,VAPA,CD74,RAMP2,JUN,PEX10,TGFB2,CHCHD4,AP3D1,RAB7A,IPO7,SOD1,SNX27,PPT1,GABARAP,SCAMP3	52	
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development	cell proliferation	cell proliferation of fibroblasts	3.05E-05	 	1.597	bias	-0.442	SOCS3,ICMT,SLC7A11,AGER,HRAS,NCSTN,HS6ST1,SGPL1,CTSD,PLCE1,CCND3,NUPR1,IFI30,ATF4,TXN,AIF1,TP53,MIF,RHEB,TNFRSF10B,RAC1,ANXA2,FOSB,TLN2,CCND2,NPR3,CTSB,DUSP4,GNL3,SFRP1,GSTP1,FTH1,HSPB1,IGFBP4,PDGFA,FGF2,ADIPOQ,SMPD1,HIF1A,CD74,PDGFC,FAS,HDGF,HMOX1,OGT,HINT1,JUN,EDN1,TIMP1,TGFB2,STAT1,NDUFS4,EMD,MAPK9,ENG,SOD1,CSF1R,FGF1,GRN,FOS	60	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	immune response	immune response of macrophages	3.07E-05	Increased	3.610	bias	2.122	GAB2,AGER,ERN1,BIN1,FAS,PTPRC,HMOX1,PTPRJ,THBS1,ANXA1,SAA1,MAPKAPK2,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,CMC2,APP,ISG15,ITGB2,TREM2,FCER1G,IL10RA,CD14,SIRPA,P2RX7	29	
Cell Death and Survival, Nervous System Development and Function, Tissue Morphology	loss	loss of neurons	3.21E-05	 	-1.243	bias	0.891	FGF2,GDF15,ADIPOQ,SLC1A3,VAC14,SMPD1,CTSD,PARK7,ANXA5,MCOLN3,CYBB,LMX1A,RET,CLCN3,GJB2,PRNP,MIF,UCP2,PSMC4,SOD1,APP,GRN,OSTM1,NR4A2,NTRK3,IL1RN,MAPT,PPT1,CTSB,PSAP,SLC1A2	31	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders	familial frontotemporal dementia	familial frontotemporal dementia	3.24E-05	 	 	 	 	GRN,PARK7,C9orf72,CHCHD10,MAPT,VCP,SQSTM1,CSF1R	8	
Protein Synthesis	polymerization	polymerization of protein	3.26E-05	 	1.910	bias	 	GFPT1,CRYAB,PFN1,SEPT9,TOR1A,NME2,HRAS,SH3GLB1,TAF10,HIST1H4C,CAMK2D,KEAP1,HIST1H3J,CDC42EP1,MTMR2,HIST1H4H,TP53,UXS1,AASS,RAC1,STOML2,FLOT1,ANXA2,TXNRD1,SCUBE1,GLUL,SQSTM1,INSR,LCP2,NACC2,NLGN1,CUTA,ADIPOQ,CTNNA1,PFKL,ME1,FAS,IRAK1,ENAH,HMOX1,NAXE,KCNMA1,ANXA5,TRABD2A,VCP,NACC1,LONP1,AMFR,ALDH5A1,NLRC4,RPS19,THBS4,AKR1C1/AKR1C2,TRIM28,DCTPP1,TRPA1,APP,FIS1,KCTD13,CLDN1,DERL1,P2RX7,SHMT2	63	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of phospholipid	3.30E-05	 	1.718	 	0.847	SCD,APOE,LEP,ARF1,ABCA3,PIK3R1,VAC14,HRAS,SMPD1,HIF1A,IL17RA,FAS,CERS2,HINT1,GLB1,ANXA5,PIK3CG,SAA1,RILP,PI4KA,MBOAT7,CERS6,SPP1,DGAT2,STOML2,NRBF2,PLA2G2A,THRSP,APP,SLC3A2,DGKQ,PIP5K1C,FCER1G,CD14,INSR,PLTP	36	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	follicular thyroid cancer	follicular thyroid cancer	3.48E-05	 	 	 	 	SPP1,TGFBR1,HRAS,FGFR2,ENG,CSF1R,NDUFA13,MT-ND1,TIMP1,SRGAP1,THBS1,KIT,INSR,TPO,RET,AMOT	16	
Cardiovascular Disease, Organismal Injury and Abnormalities	acute coronary syndrome	acute coronary syndrome	3.52E-05	 	-1.741	 	-1.161	APOE,LEP,APOB,FGF2,DUSP6,GDF15,ADIPOQ,HIF1A,NNMT,HMOX1,EDN1,CYBB,ITGAV,TUBA1C,GCLM,STAT1,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ATP5J,PTX3,PSMA6,TUBB4B,FCGR2A,TUBG1,TUBB2A,RAC1,F13A1,SOD1,CSF1R,PLA2G2A,APP,ITGB2,LGALS2,IL1RN,SH2B3,FCER1G,RTN4,TSPO,P2RY12,CD14,C6,ADRA1A	44	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis of brain	3.53E-05	 	-0.059	 	0.212	APOE,FGF2,MAPT,PPT1,LAMP1,ADIPOQ,SH3GLB1,CLCN7,APP	9	
Cancer, Hereditary Disorder, Organismal Injury and Abnormalities	hereditary neoplastic syndrome	hereditary neoplastic syndrome	3.74E-05	 	 	 	 	MT-TT,SPRED1,SDHB,TGFBR1,MSR1,DDIT3,BARD1,HRAS,FKBP1A,HIF1A,MT-CO2,ODC1,HMOX1,MT-CYB,ABCC1,RET,MLH3,TP53,MT-CO1,TRIM28,EGR1,MT-TE,SDHC,MT-ND4L,PLA2G2A,AIP,MYL9,TMEM127,CCND2,RTN4	30	
Cellular Movement	migration	migration of breast cancer cell lines	3.79E-05	Increased	2.695	bias	0.714	GAB2,NME1,TGFBR1,LEP,AGER,SEPT9,ARF1,FGF2,OSGIN1,HRAS,HIF1A,SDC4,CXCL9,ENAH,S100A7,CXCL10,JUN,TIMP1,FLNA,ANXA1,PIK3CG,ITGAV,KPNA2,NDUFAF3,TP53,PLXNA1,SPP1,BHLHE41,RAC1,FGFR2,MAPK9,ANXA2,KLF4,GIT1,ARHGDIB,FGF1,MCF2L,SDCBP,ADAM12,WBP2,CAPN2,CST6,MAP4K4,ESR2,UBE2I	45	
Hematological System Development and Function, Inflammatory Response, Tissue Morphology	quantity	quantity of phagocytes	3.79E-05	 	-0.260	 	-0.618	GAB2,SOCS3,APOB,TGFBR1,AGER,PIK3R1,LHCGR,C1QA,SLC35C1,CXCL10,PLCE1,CTSS,PIK3CG,CXCL14,MGAT4B,CYBB,STAB1,TP53,MIF,IL2RG,SPP1,LAIR1,TSPAN33,HAX1,PREX1,ADAM12,IL1RN,SH2B3,ESR2,C3AR1,SIRPA,APOE,ADAM17,LITAF,LEP,DDIT3,GDF15,ADIPOQ,SMPD1,DMD,CD83,IL17RA,PDGFC,FAS,HINT1,CES1,GBA,SORBS1,TIMP1,THBS1,KIT,S100A8,CFH,MAPKAPK2,NFE2L2,CCR1,VCAM1,TYROBP,FCGR2A,NQO1,ST3GAL6,MAPK9,SOD1,CSF1R,PI3,ITGB2,LGALS2,TREM2,FCER1G,C6	70	
Hematological System Development and Function, Tissue Development	accumulation	accumulation of blood cells	3.81E-05	 	0.815	 	-0.307	APOE,CRYAB,PFN1,F2RL3,DDIT3,AGER,FGF2,ADIPOQ,CTSG,NCSTN,IL17RA,FAS,CXCL10,CD28,HMOX1,EDN1,TIMP1,THBS1,ANXA1,PIK3CG,CYBB,KIT,S100A8,RET,STAT1,FCGR3A/FCGR3B,NLRC4,CCR1,PTX3,MIF,VCAM1,IL2RG,SPP1,TYROBP,FCGR2A,EGR1,FGFR2,MAPK9,SOD1,IRF5,FGF1,GRN,ITGB2,ACKR3,IL1RN,NR4A1,IL10RA,C6,P2RX7	49	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	metastatic breast or ovarian malignant neoplasm	metastatic breast or ovarian malignant neoplasm	3.82E-05	 	 	 	 	TP53,SPP1,TGFBR1,TUBB4B,TNFRSF10B,TUBG1,TUBB2A,LHCGR,FKBP1A,CXCL9,TUBB,DYNLRB1,POR,EDN1,THBS1,FLNA,PIK3CG,TOP2A,TGFB2,TUBA1C,STAT1,ESR2	22	
Cancer, Organismal Injury and Abnormalities	head and neck oncocytoma	head and neck oncocytoma	3.86E-05	 	 	 	 	MT-ND5,MT-ND1,KIT,HRAS,FGFR2,MT-ND4,TPO,RET,MT-ND2,CSF1R,NDUFA13	11	
Developmental Disorder, Hereditary Disorder, Metabolic Disease, Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Lebers optic atrophy with dystonia	Lebers optic atrophy with dystonia	3.93E-05	 	 	 	 	MT-ND6,MT-ND1,MT-ND4,MT-ND3	4	
Carbohydrate Metabolism, Small Molecule Biochemistry	binding	binding of heparan sulfate proteoglycan	3.93E-05	 	1.000	 	1.000	CXCL10,APOE,THBS1,MAPT	4	
Carbohydrate Metabolism	hydrolysis	hydrolysis of polysaccharide	3.93E-05	Increased	2.000	bias	1.314	CTSD,LYZ,LEP,CTSG	4	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	primary papillary thyroid carcinoma	primary papillary thyroid carcinoma	3.93E-05	 	 	 	 	MT-ND5,MT-CO3,MT-ND4,MT-ND2	4	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of L-glutamine	3.93E-05	 	 	 	 	SLC1A4,SLC1A5,SLC38A1,SLC38A3	4	
Cellular Assembly and Organization	organization	organization of organelle	3.97E-05	Increased	2.543	bias	1.448	RAB5C,TGFBR1,SESN2,ARF1,MBP,TOR1A,ITGA8,CSNK1A1,SH3GLB1,SDC4,TUBB,PLEKHM2,CD28,CFL2,MKX,GAA,SPTB,AFAP1,KIF5C,RET,CHMP1A,TP53,LCP1,DPT,CFL1,MTSS1,ACP2,MAD2L2,PHB2,CARMIL1,RAC1,STOML2,ANXA2,TMEM127,ADAM12,GAPDH,ALDOA,NAGLU,PLEK,SIRPA,ETV5,ARL2,PEX3,CHCHD10,FGF2,NLGN1,CTNNA1,FKBP1A,HEXA,SMPD1,ENAH,SEC61A1,PARK7,PPP1R9B,TNXB,FLNA,PEX10,TGFB2,SNX10,ARHGEF2,STOX1,CTDNEP1,LONP1,ACTN1,RAB8B,PLOD3,PRNP,RPS19,COL5A2,CAPZB,KRT6B,DVL1,HPS1,EMD,MFAP4,SOD1,SNCG,CSF1R,HIST1H1B,MYO5A,FIS1,KIFC3,PPT1,DYM,TPP1,P2RY12,RUFY3,P2RX7	88	
Cellular Function and Maintenance, Molecular Transport, Small Molecule Biochemistry	homeostasis	homeostasis of Cu2+	4.03E-05	 	 	 	 	APLP2,SLC31A1,ARF1,COMMD1,ATOX1,PRNP,APP	7	
Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities, Tissue Morphology	quantity	quantity of papilloma	4.03E-05	 	0.946	 	0.566	TP53,HINT1,PEA15,HRAS,MAPK9,ODC1,GSTP1	7	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of sphingolipid	4.08E-05	Increased	3.053	bias	1.282	SCD,LEP,FGF2,ADIPOQ,HEXA,SMPD1,FAS,CERS2,SGPL1,GBA,GLB1,ABCC1,KIT,NSMAF,ALDH5A1,CERS6,GM2A,ARSA,SPTLC3,DEGS1,APP,SERINC2,PPT1,MAPK10,PSAP,B3GNT5,P2RX7	27	
Cell Death and Survival	cell death	cell death of epithelial cell lines	4.11E-05	 	0.225	 	-0.983	CRYAB,TGFBR1,DDIT3,FGF2,ERN1,UNC5B,HSPB8,ADIPOQ,HRAS,HSPA5,FAS,CA3,SGPL1,DYNLL1,JUN,ABCC1,MCOLN3,ITGAV,AAK1,DAB2,NDUFAB1,NFE2L2,ATP13A2,NLRC4,PRNP,TP53,HK1,SPP1,TNFRSF10B,RAC1,SDHC,TRIB3,SOD1,CSF1R,HAX1,FGF1,APP,FOS,MYOC,NTRK3,MAPT,PEA15,GAPDH,CYCS,INSR,SFRP1,VDAC1,P2RX7,HSPB1	49	
Carbohydrate Metabolism	quantity	quantity of carbohydrate	4.13E-05	Increased	3.704	 	2.800	GFPT1,PFKFB1,AGER,ARF1,PIK3R1,ABCA3,CA5B,VAC14,HRAS,C1QA,SDC4,HSPA5,CERS2,HS6ST1,GAA,ABCC1,PIK3CG,CXCL14,ATF4,CHST11,C1QBP,CLCN3,RGL1,TP53,HK1,CERS6,MIF,SPP1,XYLT1,CPA3,TPSAB1/TPSB2,SLC3A2,OSTM1,PIP5K1C,GAPDH,CD14,INSR,ESR2,STEAP3,SCD,APOE,IGFBP4,DDAH2,LEP,FGF2,GDF15,ADIPOQ,HEXA,SMPD1,HIF1A,GANAB,FAS,OGT,HINT1,CES1,EDN1,PLIN2,ANXA5,CFH,STK40,PI4KA,MBOAT7,SRA1,UCP2,NPY1R,NQO1,DGAT2,SOD1,NRBF2,SLC5A3,THRSP,FGF1,APP,ITGB2,CIDEA,GIPR,DGKQ,PCCA,APOC1,FCER1G,NR4A1,GBE1,SIM1,ADRA1A	84	
Lipid Metabolism, Small Molecule Biochemistry	metabolism	metabolism of eicosanoid	4.20E-05	 	1.300	bias	-1.259	APOE,LEP,AGER,AKR1C3,CD4,FCER1A,ADIPOQ,CD83,CD74,POR,HMOX1,SGPL1,EDN1,ANXA1,ABCC1,HOXA10,KIT,GPC1,PRNP,TP53,ATP5J,CD209,MIF,AKR1C1/AKR1C2,FCGR2A,RAC1,ALOX5AP,MAPK9,SOD1,PLA2G2A,PLAA,GIPR,IL1RN,FCER1G,MAPK10,CD14,AKR1B1,ESR2,CYP4A11,P2RX7,NPC2,NCAM1,EPHX1	43	
Cellular Function and Maintenance	function	function of phagocytes	4.37E-05	 	0.555	bias	-0.251	GAB2,PLCB2,CMA1,UNC5B,FCER1A,CXCL10,LGMN,PIK3CG,ABCC1,CYBB,CLCN3,LCP1,IL2RG,MIF,SPP1,CAPG,CNPY3,CD14,DUSP4,SIRPA,HSPB1,APOE,GADD45B,MSR1,GDF15,PPIA,IRAK1,HLA-G,TGFB2,KIT,STAT1,NLRC4,CCR1,CD209,SIGMAR1,PLXNA1,UCP2,NPY1R,FCGR2A,TYROBP,EGR1,MAPK9,TRIB3,CSF1R,GRN,ITGB2,FOS,TREM2,MS4A2,FCER1G,PSAP,P2RX7	52	
Cancer, Organismal Injury and Abnormalities, Tumor Morphology	progression	progression of tumor	4.46E-05	 	-0.338	 	-1.159	IGFBP4,APOE,CRYAB,LEP,FGF2,GDF15,CSNK1A1,HIF1A,FAS,PLCE1,JUN,EDN1,TIMP1,ANXA1,CXCL14,STAB1,STAT1,FCGR3A/FCGR3B,TP53,MIF,SPP1,FCGR2A,FGFR2,ANXA2,ENG,FOS,ADAM12,CLDN1,ACKR3,FCER1G,ALCAM	31	
Nervous System Development and Function, Skeletal and Muscular System Development and Function	motor function	motor function	4.59E-05	 	-0.577	bias	-1.771	APOE,FGF2,PPP1R1B,HLA-A,UBQLN1,SLC12A2,TOR1A,MAP1B,RAC1,SMPD1,SOD1,SERPINE2,CERS2,APP,FTL,NR4A2,PPT1,MAPT,CLCN3,ADORA1,NFE2L2,FTH1,PRNP	23	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of leukocytes	4.64E-05	 	1.132	 	-0.094	APOE,CRYAB,PFN1,DDIT3,AGER,FGF2,ADIPOQ,CTSG,IL17RA,FAS,CXCL10,CD28,HMOX1,EDN1,TIMP1,THBS1,ANXA1,PIK3CG,CYBB,KIT,S100A8,RET,STAT1,FCGR3A/FCGR3B,NLRC4,CCR1,PTX3,MIF,VCAM1,IL2RG,SPP1,TYROBP,FCGR2A,EGR1,FGFR2,MAPK9,SOD1,IRF5,FGF1,GRN,ITGB2,ACKR3,IL1RN,NR4A1,IL10RA,C6,P2RX7	47	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of lymphocytes	4.68E-05	Increased	2.369	bias	-0.223	TGFBR1,PIK3R1,MAF,HRAS,SLC35C1,HLA-DQB1,EEF1D,CXCL10,PTPRC,CHST2,SGPL1,ZBTB7B,LGMN,CCND3,CTSS,PIK3CG,ST6GALNAC2,STAM,APEX2,TP53,LAIR1,FGFR2,HAX1,ARHGDIB,MNT,IL10RA,B3GNT5,ESR2,C3AR1,GSTP1,LCP2,BANK1,APOE,PIM3,GADD45B,DDIT3,HLA-A,PSMB10,ADIPOQ,HLA-DQA1,PPIA,CD74,PTPRJ,SORBS1,SLC19A1,CCR1,SIGLEC1,TYROBP,FCGR2A,IGKC,GNA12,EGR1,APP,ISG15,ITGB2,FOS,FCER1G,NR4A1,PSAP,ARHGDIA,SOCS3,TRAF3,CD4,MBP,LHCGR,STARD7,CD28,CTSD,COMT,STAB1,IL2RG,MIF,SPP1,RAC1,FYB,KLF4,PKN1,FOSB,ACKR3,SH2B3,PIK3AP1,SIRPA,LEP,CD83,HIF1A,IL17RA,FAS,IRAK1,HLA-G,THBS1,SAA1,DUSP10,KIT,STAT1,PRNP,VCAM1,NPY1R,NQO1,ST3GAL6,MAPK9,VSIG4,SOD1,KIFAP3,IL20RB,CSF1R,CXCL16,LGALS2,PAG1,P2RX7,CARM1	110	
Cellular Growth and Proliferation, Tissue Development	generation	generation of cells	4.86E-05	Increased	5.618	bias	1.131	TGFBR1,AGER,PIK3R1,CLSTN2,SLC9A1,CLIP1,ODC1,SPRY4,PTPRC,CCND3,SRPX2,MCOLN3,SPTB,ATF4,ARHGEF26,STAM,PLXNB2,TMSB10/TMSB4X,TP53,YWHAG,LAIR1,PAQR3,MAD2L2,FGFR2,FLOT1,ANXA2,IRF5,ARHGDIB,MYL9,BTG2,CTSB,SQSTM1,DEAF1,RAP2A,APOE,NME1,SLC4A2,GADD45B,GBP1,FGF2,HLA-DQA1,ADIPOQ,LGALS9,PPIA,HEXA,CD74,SHTN1,PTPRJ,PLIN2,DAB2,NFE2L2,CCR1,UCP2,FCGR2A,IGKC,MESP1,ENG,HSPA2,CPEB4,GRN,MYO5A,FOS,MYOC,NR4A2,NTRK3,PPT1,NR4A1,ARHGDIA,SOX9,BMPER,DCX,SOCS3,TRAF3,NCDN,YWHAH,SEPT9,ABCA3,MBP,NRN1,NNMT,CD28,HS6ST1,HSPA4,HSF4,RHOG,HOXA10,MTMR2,CNTNAP1,PFKFB3,IL2RG,STK39,RILPL1,MAPK8IP2,RIMS4,DMTN,UBA6,ARSA,KLF4,SLC3A2,METRN,SDCBP,SPINK5,PDCL3,ADAM12,NAGLU,INSR,SIRPA,HSPB1,ETV5,CD151,PEBP1,MSR1,FLRT1,DMD,IL17RA,PDGFC,HNRNPK,CIAPIN1,HLA-G,EDN1,TIMP1,SAA1,STAT1,LONP1,THBS4,VCAM1,CAPZB,SLC12A2,DVL1,NQO1,G6PD,SOD1,GIT1,KIF3B,FGF1,SHB,CAPNS1,SLC14A1,TTL,MAP4K4,THEMIS2,APOB,ITSN1,TOR1A,SNTA1,MAF,HRAS,DDX20,HLA-DQB1,ADGRL1,EEF1D,CXCL10,ZBTB7B,SGPL1,DYNLL1,LGMN,PIK3CG,TXN,ZBTB16,SFRP4,RIMS3,HMGA1,MNT,ANGPTL1,NR1D1,PIP5K1C,TINCR,STIP1,PRELID1,IL10RA,RTN4,SFRP1,TCF7,CYR61,C3AR1,RORB,LCP2,ADAM17,MSC,BTG3,HLA-A,CDK16,SLC1A3,TSGA10,FKBP1A,ENAH,MAFG,UCHL1,JUN,SNX10,LAMP1,SLC19A1,STIM1,NPTXR,PLOD3,ADGRB2,RPS19,PTPRK,ADRM1,TYROBP,EGR1,SLIRP,APP,ADGRG2,ITGB2,SOX6,SBF1,TENM4,ADCY1,FCER1G,CYCS,RUFY3,NCAM1,HOXB5,PFN1,CD4,MAP1B,LHCGR,SDC4,DYNLT1,CYBB,CHST11,GPC1,RET,MIF,SPP1,RAB10,PHB2,RAC1,SYP,SIPA1L1,PREX1,IL1RN,SH2B3,MAPT,FMN2,LFNG,PAFAH1B2,SPRED1,RNF165,LEP,EPB41L3,CD2,NLGN1,PDGFA,ERN1,VAPA,PKM,SMPD1,CD83,HIF1A,FAS,TNFRSF12A,HMOX1,PPP1R9B,THBS1,FLNA,ANXA1,DUSP10,TGFB2,KIT,NSMF,S100A8,NR2F6,MAPKAPK2,CTDNEP1,ACTN1,PRNP,AP3D1,MAPK9,F13A1,MKNK2,PLXND1,CSF1R,EDF1,KIF2A,PAG1,EPHB3,NCKAP1L,CPEB1,RTN3,P2RX7,CARM1	283	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of lipid	4.90E-05	Increased	2.492	 	1.865	APOB,PLIN1,PIK3R1,VAC14,HRAS,C1QA,KPNA1,POR,SGPL1,CTSS,GLB1,PIK3CG,PLIN5,ZBTB16,TP53,CERS6,TSPYL5,STOML2,FGFR2,HMGA1,PIP5K1C,PLTP,B3GNT5,ESR2,APOE,SRD5A1,ADIPOQ,CES1,JUN,GBA,SORBS1,ANXA5,PLIN2,SCNN1B,ADORA1,HCAR2,AMFR,PI4KA,MBOAT7,SIGMAR1,UCP2,EGR1,DGAT2,ALOX5AP,ENG,PLA2G2A,APP,FOS,SREBF2,FCER1G,FKBP4,NR4A1,NR5A2,PSAP,ARHGDIA,ABCC3,NPC2,TRAF3,PFKFB1,ARF1,CD4,ABCA3,MBP,LHCGR,RAB9A,CERS2,HS6ST1,CTSD,CYP3A5,ENTPD5,COMT,CXCL14,CYBB,RILP,NSMAF,MIF,SPP1,STK39,RAC1,SLC3A2,IL1RN,CD14,NAGLU,INSR,AKR1B1,PTGFR,ANGPTL8,SCD,LEP,MSR1,SMPD1,HIF1A,IL17RA,FAS,TNFRSF12A,HMOX1,HINT1,EDN1,PCK2,KCNMA1,TIMP1,SAA1,LOC102724428/SIK1,S100A8,CFH,MAPKAPK2,CTDNEP1,PRNP,VCAM1,SLC9A3R1,NPY1R,SLC12A2,NQO1,RAB7A,NXPH4,SOD1,NRBF2,THRSP,CIDEA,DGKQ,APOC1,SLC1A2,P2RX7	123	
Neurological Disease, Organismal Injury and Abnormalities	brain atrophy	brain atrophy	5.00E-05	 	0.000	bias	0.864	RHEB,CHCHD10,C9orf72,ADIPOQ,SOD1,CSF1R,APP,GRN,PARK7,PPT1,MAPT,VCP,CTSB,SQSTM1,PRNP	15	
Cellular Compromise	oxidative stress response	oxidative stress response of cells	5.00E-05	 	-0.565	 	0.012	TP53,LEP,DDIT3,NQO1,SOD1,NFE2L1,APP,HMOX1,ALDH3A2,MAPT,ATF4,STIM1,ISCU,INSR,NFE2L2	15	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of lipid	5.00E-05	Increased	2.421	bias	0.301	SCD,APOE,LEP,APOB,MSR1,AGER,GDF15,ADIPOQ,HRAS,CRAT,SMPD1,IRAK1,CES1,CTSS,PLIN2,ABCC1,SAA1,ITGAV,S100A8,HCAR2,TP53,ACSL3,AKR1C1/AKR1C2,SLC9A3R1,GM2A,SNTB1,RAC1,SLC25A1,APP,HSPA8,GIPR,PRELID1,APOC1,RTN4,TSPO,CD14,PSAP,PLTP,ABCC3,P2RX7,NPC2,EPHX1	42	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	migration of mononuclear leukocytes	5.00E-05	Increased	3.834	bias	1.040	SOCS3,PLCB2,AGER,CD4,CTSG,FCER1A,HRAS,CXCL9,CXCL10,CD28,SGPL1,CTSS,PIK3CG,ABCC1,ITGAV,STAB1,LCP1,MIF,SPP1,RAC1,ANXA2,FYB,NINJ1,EFS,PIP5K1C,ACKR3,MAPK10,ESR2,SIRPA,LCP2,CD151,RAP2A,ADAM17,LEP,CD2,HLA-A,HYOU1,SMPD1,CD74,IL17RA,FAS,S100A7,HLA-G,JUN,TIMP1,THBS1,SAA1,CCL28,ANXA1,STAT1,CCR1,CD209,VCAM1,GNA12,ENG,APP,FOS,CXCL16,ITGB2,NR4A1,C6,P2RX7	62	
Cell Death and Survival	killing	killing of cells	5.02E-05	 	1.842	 	0.480	LEP,MSR1,AGER,FGF2,HLA-A,MBP,CTSG,SMPD1,HIF1A,HSPA5,HNRNPK,FAS,CEBPG,CXCL10,POR,HLA-G,CD28,CTSD,LYZ,CTSS,CCL28,CXCL14,CYBB,LAMP1,STAT1,NFE2L2,TP53,THBS4,TNFRSF10B,RAB7A,VSIG4,PLA2G2A,APP,PI3,PIP5K1C,NR4A1,IL10RA,SIRPA,GSTP1	39	
Cellular Assembly and Organization, Tissue Development	fibrogenesis	fibrogenesis	5.03E-05	 	1.642	bias	-0.499	PFN1,ARF1,MBP,PIK3R1,MAP1B,FCER1A,HRAS,SDC4,HSPA5,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,CNTNAP1,AIF1,TESK1,MIF,CFL1,MTSS1,THSD4,GNG2,CARMIL1,RAC1,TPM3,MLST8,HAX1,LMCD1,PREX1,MAPT,CD14,C3AR1,SIRPA,HSPB1,ARL2,APOE,FHL1,LEP,STMN2,FGF2,HIF1A,PHLDB2,RAP1GDS1,EDN1,SORBS1,TUB,DAB2,ARHGEF2,GNG5,ASAP3,ADORA1,AMOT,KRT14,VCAM1,CAPZB,FCGR2A,GNA12,FGF1,APP,MCF2L,KCTD13,MYOC,CXXC5,FKBP4,NCKAP1L,DCX	68	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of myeloid cells	5.03E-05	 	1.453	bias	-0.621	APOE,ADAM17,KDM6B,LEP,PIK3R1,GDF15,CTSG,CD74,CXCL9,IL17RA,CXCL10,CD28,LYZ,EDN1,THBS1,ANXA1,PIK3CG,S100A8,FCGR3A/FCGR3B,CCR1,PTX3,MIF,VCAM1,SPP1,FCGR2A,RAC1,ST3GAL6,ALOX5AP,FLOT1,CSF1R,TPSAB1/TPSB2,SPON2,APP,ITGB2,PREX1,PIP5K1C,IL1RN,RTN4,CD14,SFRP1,C3AR1	41	
Organismal Development	abnormal morphology	abnormal morphology of body cavity	5.07E-05	 	 	 	 	PLIN1,KDM6B,AGER,RRM2B,ITGA8,NCSTN,SLC35C1,HLA-DQB1,KPNA1,APRT,PTPRC,POR,LGMN,CCND3,ARID3B,GAA,PIK3CG,PLIN5,ATF4,UNG,TP53,RBM38,RHEB,MTSS1,CSRP2,MAD2L2,FGFR2,TSPAN33,HMGA1,ARHGDIB,SYTL1,CTSA,CCND2,ARHGAP35,B3GNT5,C3AR1,ESR2,STEAP3,LCP2,BANK1,APOE,HIST1H1C,ADAM17,SLC4A2,SRD5A1,FGF2,GDF15,HSPB8,HLA-DQA1,ADIPOQ,FKBP1A,HEXA,PIP,CES1,JUN,GBA,PTPRJ,SLC19A1,DAB2,SCNN1B,NFE2L2,CCR1,KRT6B,IGKC,EGR1,MESP1,LZTS2,KRT5,COPS3,GRN,FOS,ITGB2,LAMP2,GLIS2,NTRK3,PPT1,FCER1G,FKBP4,NR5A2,PSAP,ARHGDIA,DVL3,SOX9,BMPER,SOCS3,DAD1,ABCA3,CD4,LHCGR,SDC4,BIN1,CEBPG,CD28,CTSD,RSPO3,HS6ST1,PLCE1,COMT,ENTPD5,HOXA10,CYBB,ITGAV,NUPR1,HOXA7,ANXA7,RET,CLCN3,TOP3B,EIF2AK1,PTX3,MIF,IL2RG,SPP1,SGCG,PCSK6,MAPK8IP2,PHB2,KLF4,PREX1,ADAM12,ACKR3,IL1RN,SH2B3,FMN2,NAGLU,CAPN2,LFNG,H1F0,INSR,MEGF8,AKR1B1,TNS1,RPSA,CD151,IGFBP4,MSR1,PDGFA,SMPD1,HIF1A,RAMP2,FAS,CIAPIN1,HMOX1,SLC19A3,EDN1,THBS1,FLNA,TGFB2,CFH,STAT1,ALPL,VCAM1,SLC9A3R1,TRIM55,NPY1R,SLC12A2,MTMR14,NQO1,G6PD,EMD,MAPK9,SOD1,SNX27,KIFAP3,CSF1R,KIF3B,CISD2,PLXND1,NFE2L1,PCCA,EPHB3,GBE1,CARM1	173	
Cellular Development, Cellular Growth and Proliferation, Organ Development, Skeletal and Muscular System Development and Function, Tissue Development	proliferation	proliferation of smooth muscle cells	5.14E-05	Increased	2.623	 	1.482	SOCS3,IGFBP4,APOE,FHL1,LEP,AGER,FGF2,PIK3R1,CMA1,FCER1A,ADIPOQ,PPIA,HIF1A,SLC9A1,IRAK1,C1QTNF9,HMOX1,JUN,CAMK2D,EDN1,THBS1,COMT,STIM1,AIF1,TXN,STAT1,NFE2L2,TP53,MIF,SPP1,EGR1,TNFRSF10B,NQO1,RAC1,FGFR2,ALOX5AP,KLF4,CXCL16,FOS,NR4A2,NPR3,IL1RN,NR4A1,CAPN2,INSR,AKR1B1,ESR2,C3AR1,SIRPA	49	
Nucleic Acid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of nucleotide	5.15E-05	 	1.735	bias	-0.065	SOCS3,AGER,ATP5D,RRM2B,LHCGR,NME2,HRAS,NNMT,GNB1,AK1,G0S2,UQCC2,PIK3CG,NMNAT2,TP53,SPP1,SURF1,CTPS1,ADCYAP1R1,MAPT,ALDOA,RAMP3,INSR,VDAC1,RPSA,APOE,ATP5G1,LEP,CHCHD10,FGF2,PKM,COASY,SMPD1,HIF1A,ME1,DTYMK,RAMP2,FAS,HMOX1,ALDH2,EDN1,VCP,MT-CO3,HCAR2,LONP1,ADCY2,MT-ATP6,UCP2,LETM1,USMG5,G6PD,SOD1,APP,MRAP,GIPR,ADCY1,PANK3,P2RY12,CYCS,SLC25A5	60	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of glycosphingolipid	5.23E-05	 	-1.266	 	-0.784	GBA,GLB1,GM2A,PSAP,HEXA,SMPD1,ARSA,FAS,GULP1,NPC2,APP	11	
Cellular Assembly and Organization, Tissue Development	formation	formation of filaments	5.25E-05	 	1.930	bias	-0.243	PFN1,ARF1,MBP,PIK3R1,MAP1B,FCER1A,HRAS,SDC4,HSPA5,TUBB,SLC9A1,CLIP1,GNB1,DYNLL1,GLB1,CHCHD2,CNTNAP1,AIF1,TESK1,MIF,CFL1,MTSS1,THSD4,GNG2,CARMIL1,RAC1,TPM3,MLST8,HAX1,LMCD1,PREX1,MAPT,C3AR1,SIRPA,HSPB1,ARL2,APOE,FHL1,LEP,STMN2,FGF2,PHLDB2,RAP1GDS1,EDN1,SORBS1,TUB,DAB2,ARHGEF2,GNG5,ASAP3,ADORA1,AMOT,KRT14,VCAM1,CAPZB,FCGR2A,GNA12,FGF1,APP,MCF2L,KCTD13,MYOC,CXXC5,FKBP4,NCKAP1L,DCX	66	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of cholesterol	5.35E-05	 	1.648	bias	0.466	TP53,SCD,APOE,APOB,LEP,MSR1,AGER,GDF15,SNTB1,RAC1,ADIPOQ,HRAS,SLC25A1,SMPD1,IRAK1,APP,CES1,CTSS,SAA1,APOC1,TSPO,S100A8,PLTP,HCAR2,NPC2	25	
Cell Death and Survival	apoptosis	apoptosis of breast cancer cell lines	5.38E-05	 	-0.580	 	-0.770	TGFBR1,HSPA5,SLC9A1,KPNA2,MYBBP1A,TP53,MIF,LMO4,TNFRSF10B,RAC1,SDHC,DPH2,DUSP4,SFRP1,CYR61,ESR2,HSPB1,FTH1,PEBP1,NME1,NACC2,OSGIN1,FGF2,PKM,BARD1,ADIPOQ,HSPB8,SMPD1,HIF1A,FAS,HMOX1,RABL6,HINT1,JUN,THBS1,VCP,TGFB2,DAB2,STAT1,HCAR2,NLRC4,PRNP,NQO1,MAPK9,NDUFA13,PI3,KIFC3,PEA15,CYCS,ARHGDIA	50	
DNA Replication, Recombination, and Repair	metabolism	metabolism of DNA	5.53E-05	 	1.466	 	0.541	ABCB6,SOCS3,CRYAB,PFN1,PIK3R1,RRM2B,RAN,CTSG,HRAS,TYMP,BIN1,CD28,KEAP1,KPNA2,TP53,RPA4,FBL,PRKRA,RAC1,HMGA1,TPSAB1/TPSB2,SSBP1,MAPT,RTN4,ORC5,CAPN2,INSR,POLD2,HSPB1,S100A11,IGFBP4,APOE,NME1,LEP,CD2,MSR1,DDIT3,UBQLN1,PDGFA,DNASE1L3,FGF2,PAM16,BARD1,ADIPOQ,PPIA,PDGFC,FAS,JUN,TOP2A,TGFB2,NACC1,STAT1,MAPKAPK2,PRNP,CD53,MAPK9,SOD1,APP,GRN,ENO1,KCTD13,PPT1,MMS19,NR4A1,PEA15	65	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of glucosylceramide	5.69E-05	 	-1.982	bias	 	GBA,GLB1,PSAP,SMPD1,NPC2	5	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	primary thyroid gland neoplasm	primary thyroid gland neoplasm	5.69E-05	 	 	 	 	MT-ND6,MT-ND5,MT-CO3,MT-ND4,MT-ND2	5	
Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry	transport	transport of glutamine	5.69E-05	 	 	 	 	CD28,SLC1A4,SLC1A5,SLC38A1,SLC38A3	5	
Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities	cell death	cell death of liver cells	5.85E-05	 	-0.037	 	0.234	SCD,SOCS3,APOE,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,SMPD1,TMBIM6,FAS,CXCL10,PTPRC,HMOX1,ALDH2,JUN,TIMP1,SAA1,ENTPD5,ITGAV,CFH,STAT1,NFE2L2,TP53,MAPK9,IRF5,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,DUSP4,SLC25A5	36	
Cell Death and Survival	cytolysis	cytolysis	5.98E-05	 	1.248	 	0.875	NME1,HLA-A,ABCA3,CD4,SH3BGRL3,FCER1A,GSS,FAS,CEBPG,PTPRC,HLA-G,CD28,HMOX1,AK1,LYZ,IGHG3,ANXA1,PIK3CG,SPTB,CFH,STAT1,NFE2L2,KRT10,FCGR3A/FCGR3B,TP53,HK1,EIF2AK1,IL2RG,SPP1,TYROBP,FCGR2A,IGKC,TNFRSF10B,G6PD,DMTN,CD52,ISG15,APP,ITGB2,FCER1G,KRT6A,ALDOA,P2RY12,STK31,P2RX7,LCP2	46	
Cell-To-Cell Signaling and Interaction, Nervous System Development and Function	activation	activation of neuroglia	5.99E-05	 	0.856	 	-0.179	TP53,APOE,MIF,GJB6,TRAF3,ADIPOQ,ANXA2,SOD1,TNFRSF12A,FGF1,APP,OSTM1,CXCL10,HMOX1,EDN1,IL1RN,TREM2,PPT1,MAPT,CYBB,ITGAV,CLCN7,ADORA1,STAT1,P2RX7,PRNP	26	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	Lymphocyte migration	6.00E-05	Increased	3.352	bias	0.653	SOCS3,PLCB2,CD4,CTSG,FCER1A,HRAS,CXCL9,CXCL10,CD28,SGPL1,CTSS,PIK3CG,ABCC1,ITGAV,STAB1,LCP1,MIF,SPP1,RAC1,FYB,EFS,PIP5K1C,ACKR3,MAPK10,ESR2,LCP2,CD151,RAP2A,ADAM17,LEP,CD2,HLA-A,HYOU1,SMPD1,CD74,IL17RA,FAS,S100A7,HLA-G,JUN,THBS1,TIMP1,ANXA1,SAA1,CCL28,STAT1,CCR1,CD209,VCAM1,GNA12,ENG,APP,FOS,CXCL16,ITGB2,NR4A1,C6,P2RX7	58	
Cell Death and Survival	apoptosis	apoptosis of connective tissue cells	6.02E-05	 	-0.215	 	-0.229	TRAF3,TGFBR1,AGER,PIK3R1,SH3GLB1,HRAS,HSPA5,GLO1,CTBP1,SGPL1,CTSD,PIK3CG,NUPR1,ITGAV,NSMAF,TP53,TNFRSF10B,RAC1,FGFR2,ADAM12,MBD4,DUSP4,GNL3,SFRP1,INSR,LEP,DDIT3,NELFB,FGF2,ATF5,ADIPOQ,FAS,JUN,TIMP1,SAA1,TGFB2,S100A8,NFE2L2,MAPK9,EMD,ENG,SOD1,NFE2L1,APP,GRN,MCF2L,CIDEA,CAPNS1,USP22,NR4A1,CYCS	51	
Cellular Growth and Proliferation, Tissue Development	proliferation	proliferation of connective tissue cells	6.03E-05	 	1.701	 	-0.407	ICMT,SOCS3,TRAF3,SLC7A11,ITSN1,AGER,HRAS,NCSTN,MKI67,SDC4,CTSD,HS6ST1,SGPL1,PLCE1,CCND3,HOXA10,ITGAV,NUPR1,IFI30,ATF4,TXN,AIF1,RET,WNT5B,TP53,MIF,RHEB,SPP1,PAQR3,TNFRSF10B,RAC1,FGFR2,TPM3,ANXA2,KLF4,RASD1,SLC3A2,FOSB,TLN2,CCND2,NPR3,CTSB,GNL3,DUSP4,INSR,SFRP1,CYR61,ESR2,GSTP1,FTH1,HSPB1,S100A11,IGFBP4,LEP,FGF2,PDGFA,ADIPOQ,SMPD1,HIF1A,ATRAID,CD74,PDGFC,FAS,TNFRSF12A,HDGF,OGT,HMOX1,HINT1,JUN,EDN1,TIMP1,KCNMA1,SAA1,TGFB2,MAPKAPK2,STAT1,NFE2L2,KRT10,NDUFS4,PTPRK,EMD,MAPK9,ENG,SOD1,CSF1R,ATIC,FGF1,GRN,FOS,MCF2L,CAPNS1,NTRK3,TREM2	93	
Hematological System Development and Function, Tissue Morphology	abnormal quantity	abnormal quantity of leukocytes	6.18E-05	 	 	 	 	SIGLEC1,APOE,IL2RG,NPY1R,FCGR2A,IGKC,EGR1,CD4,CD74,CSF1R,ARHGDIB,HAX1,CXCL10,PTPRC,ZBTB7B,HMOX1,IL1RN,SH2B3,ARHGDIA,ESR2	20	
Dermatological Diseases and Conditions, Infectious Diseases	lepromatous leprosy	lepromatous leprosy	6.41E-05	 	 	 	 	CCR1,PLXNA1,IL2RG,CD160,IGHG3,MSR1,FCGR2A,CD4,GDF15,FCER1G,CD14,CD83,SIRPA	13	
Cell Death and Survival	apoptosis	apoptosis of vascular endothelial cells	6.54E-05	 	1.446	 	1.262	TP53,TGFBR1,UCP2,SPP1,LEP,ITSN1,DDIT3,FGF2,DUSP6,TNFRSF10B,ADIPOQ,MAPK9,HSPA5,FAS,APP,ALDH2,HMOX1,THBS1,CYCS,S100A8,VDAC1	21	
Organismal Development	size	size of body	6.82E-05	Increased	8.040	bias	 	ITSN1,AGER,PCLO,PIK3R1,CA5B,MAF,SLC35C1,SLC9A1,APRT,SPRY4,PTPRC,SGPL1,LGMN,CCND3,ST6GALNAC2,ATF4,TP53,SURF1,MAD2L2,FGFR2,ANXA2,HMGA1,HAX1,MNT,CTSA,NPR3,ARHGAP35,RAMP3,SFRP1,ACTG1,ESR2,HIST1H1C,APOE,ADAM17,PIM3,SLC4A2,GDF15,ADIPOQ,CD74,PTPRJ,PLIN2,SLC19A1,STIM1,SCNN1B,ALDH5A1,NDUFS4,MBOAT7,KRT6B,TYROBP,DGAT2,POMGNT1,APP,FOS,COL5A3,LAMP2,NTRK3,FCER1G,PEA15,FKBP4,PSAP,BMPER,SIM1,NCAM1,ICMT,PER1,TRAF3,UBE2A,MAP1B,LHCGR,NRN1,PNRC2,CTBP1,CTSD,HS6ST1,CFL2,STC2,ENTPD5,CXCL14,CYBB,ANXA7,MTMR2,CLCN3,PRKRA,SPP1,SGCG,MAPK8IP2,BAMBI,FOSB,PREX1,ADCYAP1R1,IL1RN,CNPY3,CLCN7,LFNG,H1F0,INSR,SIRPA,ETV5,SUMO3,IGFBP4,SPRED1,LEP,PDGFA,NLGN1,SLC7A1,SMPD1,HMOX1,HINT1,PPP1R9B,PREPL,KCNMA1,TGFB2,STAT1,ALPL,COL5A2,TPST2,NPY1R,SLC12A2,NQO1,G6PD,SOD1,GIT1,CISD2,SLC5A3,CSF1R,APLP2,SLC14A1,P2RX7	128	
Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Tissue Development	development	development of blood cells	6.99E-05	Increased	4.074	bias	0.921	THEMIS2,TGFBR1,PIK3R1,MAF,HRAS,HLA-DQB1,EEF1D,CXCL10,PTPRC,SGPL1,ZBTB7B,CCND3,PIK3CG,SPTB,ZBTB16,TP53,LAIR1,HMGA1,IRF5,MYL9,MNT,PRELID1,IL10RA,SFRP1,TCF7,CYR61,C3AR1,LCP2,ADAM17,MSC,GADD45B,HLA-A,FGF2,HLA-DQA1,LGALS9,FKBP1A,CD74,MAFG,JUN,PLIN2,LAMP1,SLC19A1,STIM1,NFE2L2,RPS19,FCGR2A,TYROBP,IGKC,EGR1,MESP1,ITGB2,FOS,NR4A2,SOX6,NR4A1,FCER1G,CYCS,SOCS3,TRAF3,CD4,MBP,CD28,HOXA10,IL2RG,MIF,SPP1,PHB2,RAC1,DMTN,KLF4,SLC3A2,PREX1,SPINK5,ADAM12,IL1RN,SH2B3,LFNG,LEP,MSR1,CD2,ERN1,CD83,SMPD1,HIF1A,IL17RA,FAS,HLA-G,CIAPIN1,HMOX1,DUSP10,ANXA1,TGFB2,KIT,NR2F6,STAT1,MAPKAPK2,LONP1,ACTN1,PRNP,AP3D1,NQO1,G6PD,MAPK9,SOD1,MKNK2,CSF1R,SHB,PAG1,NCKAP1L,P2RX7,CARM1	111	
Cellular Movement, Hematological Disease, Immunological Disease, Inflammatory Disease, Inflammatory Response, Respiratory Disease	allergic pulmonary eosinophilia	allergic pulmonary eosinophilia	7.00E-05	 	 	 	 	ENO1,ALDH2,PREX1,AGER,CTSS,ADIPOQ,HNRNPAB,GAPDH,ALDOA,HSPA5,TUBB	11	
Lipid Metabolism, Small Molecule Biochemistry	distribution	distribution of lipid	7.00E-05	 	0.478	 	-0.171	PTPRC,CD28,APOE,LEP,RAC1,RAB9A,SMPD1,PLTP,CHMP1A,P2RX7,APP	11	
Cell Signaling, Molecular Transport, Small Molecule Biochemistry, Vitamin and Mineral Metabolism	release	release of Ca2+	7.10E-05	 	1.746	bias	0.035	S100A11,FPR3,RAB32,LEP,DDIT3,AHCYL1,FGF2,CD4,FKBP1A,TMBIM6,FAS,PTPRC,CD28,EDN1,ANXA1,PACS2,ITGAV,CYBB,STIM1,ASPH,BCAP31,ADORA1,PRNP,TP53,CERS6,S100A1,SPP1,LMO4,FCGR2A,DVL1,SOD1,CSF1R,APP,MYO5A,FCER1G,P2RY12,P2RX7	37	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	benign neoplasm of female genital organ	benign neoplasm of female genital organ	7.12E-05	 	 	 	 	SOCS3,RPE,MEGF9,AHCYL1,PIK3R1,MAF,LHCGR,RAB9A,MT-CO2,PIK3CG,KEAP1,CXCL14,RPL19,WNT5B,TP53,SLC2A5,CAPN6,PSMA6,DPT,PLD3,SPP1,SLC24A3,AP2S1,PIK3R3,KCNG1,ADAM12,ALDOA,ARHGAP35,SFRP1,CYR61,TMEM176B,ESR2,RORB,FTH1,HIST1H1C,IGFBP4,APOE,PHLDA2,FGF2,PKM,SLC7A1,PLPP1,RAMP2,COL15A1,FAS,JUN,VCP,KIT,DAB2,CFH,STAT1,PI4KA,RPS19,DLGAP4,DVL1,SLC5A3,STXBP6,S100A2,FOS,RPS15,NR4A2,PCCA,CXXC5,NR4A1,NR5A2,SEMA3C,DCX,ADRA1A	68	
Carbohydrate Metabolism	synthesis	synthesis of polysaccharide	7.30E-05	 	-0.224	bias	-1.459	SOCS3,APOE,GFPT1,LEP,TGFBR1,FGF2,HS2ST1,ADIPOQ,HRAS,HEXA,CXCL10,HS6ST1,GYS1,EDN1,CCND3,SORBS1,TGFB2,CHST11,GPC1,PPP1CA,ADCY2,SPP1,XYLT1,RAB10,CSF1R,GYS2,NR1D1,NTRK3,IL1RN,NR4A1,GBE1,SFRP1,INSR	33	
Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	neurogenic muscular atrophy	neurogenic muscular atrophy	7.52E-05	 	 	 	 	HK1,LITAF,HINT1,SEPT9,SBF1,YARS,SURF1,RAB7A,HSPB8,GARS,NAGLU,MTMR2,AARS,MARS,HSPB1	15	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	metastatic breast cancer	metastatic breast cancer	7.56E-05	 	 	 	 	TP53,SPP1,TGFBR1,TUBB4B,TNFRSF10B,TUBG1,TUBB2A,LHCGR,FKBP1A,CXCL9,TUBB,POR,EDN1,FLNA,THBS1,PIK3CG,TOP2A,TGFB2,TUBA1C,STAT1,ESR2	21	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	differentiated thyroid cancer	differentiated thyroid cancer	7.61E-05	 	 	 	 	S100A11,TGFBR1,HRAS,PTPRC,SRGAP1,THBS1,TIMP1,MT-CO3,KIT,TPO,RET,MT-ND2,AMOT,TP53,SPP1,RAC1,FGFR2,MT-ND4,ENG,CSF1R,NDUFA13,MT-ND1,MT-ND5,INSR,MT-ND3,ABCC3	26	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	nonmedullary thyroid cancer	nonmedullary thyroid cancer	7.61E-05	 	 	 	 	S100A11,TGFBR1,HRAS,PTPRC,SRGAP1,THBS1,TIMP1,MT-CO3,KIT,TPO,RET,MT-ND2,AMOT,TP53,SPP1,RAC1,FGFR2,MT-ND4,ENG,CSF1R,NDUFA13,MT-ND1,MT-ND5,INSR,MT-ND3,ABCC3	26	
Cardiovascular System Development and Function, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Organismal Development, Tissue Development	proliferation	proliferation of endothelial cells	7.68E-05	 	0.356	 	-0.665	HOXB5,TGFBR1,SEPT9,AGER,SDC4,SPRY4,CXCL10,CYBB,GPC1,TP53,PFKFB3,YWHAG,STK39,PAQR3,RAC1,FGFR2,ANGPTL1,PDCL3,CTSB,APOE,SPRED1,LEP,GBP1,ERN1,FGF2,PKM,ADIPOQ,PPIA,HIF1A,PDGFC,TNFRSF12A,HMOX1,JUN,EDN1,THBS1,SAA1,TGFB2,DAB2,KIT,S100A8,STAT1,THBS4,EGR1,G6PD,ENG,CSF1R,EDF1,APP,FGF1,GRN,NR4A1,BMPER	52	
Digestive System Development and Function, Hepatic System Development and Function, Organ Development	response	response of liver	7.70E-05	Decreased	-2.356	bias	-0.625	TRAF3,APOB,POR,CXCL10,PTPRC,ENTPD5,GAA,STAB1,ZBTB16,TP53,IL2RG,SPP1,TNFRSF10B,EFS,IL1RN,IL10RA,CD14,NAGLU,INSR,CYR61,LCP2,GSTP1,APOE,SCD,LEP,F2RL3,DDIT3,HLA-A,ADIPOQ,LGALS9,PPIA,FKBP1A,SMPD1,IL17RA,FAS,HMOX1,SLC19A3,PTPRJ,TIMP1,STAT1,ADORA1,NFE2L2,FCGR3A/FCGR3B,TYROBP,FCGR2A,EGR1,MAPK9,SOD1,NFE2L1,ITGB2	50	
Cell Death and Survival, Neurological Disease	cell death	cell death of cerebral cortex cells	7.70E-05	 	-1.186	 	-1.154	APOE,LEP,ITSN1,DDIT3,UBQLN1,VAPA,MAP1B,HYOU1,SH3GLB1,HIF1A,HSPA5,FAS,CTSD,JUN,GBA,PARK7,PPP1R9B,GCLM,ADORA1,NFE2L2,UNG,ATP13A2,PRNP,TP53,MIF,UCP2,SOD1,APP,CAPNS1,ADAM12,NTRK3,IL1RN,MAPT,STIP1,PEA15,MAPK10,GAPDH,SLC1A2,CYCS,HSPB1	40	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of eicosanoid	7.75E-05	 	1.048	bias	-1.418	APOE,LEP,AGER,CD4,ADIPOQ,FCER1A,CD83,CD74,HMOX1,SGPL1,EDN1,ANXA1,ABCC1,HOXA10,KIT,GPC1,PRNP,TP53,ATP5J,CD209,MIF,FCGR2A,RAC1,MAPK9,ALOX5AP,SOD1,PLA2G2A,PLAA,GIPR,IL1RN,FCER1G,MAPK10,CD14,AKR1B1,ESR2,CYP4A11,P2RX7,NPC2,NCAM1	39	
Molecular Transport	quantity	quantity of heavy metal	7.82E-05	 	-1.442	 	-0.737	EIF2AK1,CRYAB,SLC31A1,ARF1,HLA-A,AP3D1,SOD1,FAS,APP,CISD1,HMOX1,FTL,APLP2,COMMD1,SLC40A1,BMPER,STEAP3,FTH1,PRNP	19	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response	binding	binding of professional phagocytic cells	7.88E-05	 	1.127	bias	-0.642	CCR1,APOE,CD209,VCAM1,CD2,MSR1,AGER,FGF2,FCGR2A,CD4,CTSG,ADIPOQ,DNAJC1,CD83,APP,FGF1,PTPRC,CXCL10,ITGB2,JUN,KIT,CD14,FCGR3A/FCGR3B	23	
Cell Death and Survival, Organismal Injury and Abnormalities, Renal and Urological Disease	cell death	cell death of kidney cell lines	7.97E-05	 	-0.005	 	-1.275	CRYAB,UNC5B,HRAS,HSPA5,SGPL1,RHOG,MCOLN3,ABCC1,ITGAV,NEO1,DPM3,HK1,TP53,SPP1,GNG2,BCL2L14,TNFRSF10B,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,VDAC1,GSTP1,HSPB1,CD2,DDIT3,ERN1,HYOU1,FAS,VCP,AAK1,NDUFAB1,NFE2L2,ATP13A2,NLRC4,TMEM123,PRNP,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,SREBF2,NTRK3,PEA15,CYCS,P2RX7	51	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of cerebroside	7.99E-05	Decreased	-2.219	bias	 	GBA,GLB1,PSAP,SMPD1,ARSA,NPC2	6	
Neurological Disease, Organismal Injury and Abnormalities	astrocytosis	astrocytosis of hippocampus	7.99E-05	 	0.555	 	1.062	APOE,MAPT,PPT1,ADIPOQ,CLCN7,APP	6	
Cellular Movement	cellular infiltration	infiltration by neuroglia	7.99E-05	 	 	 	 	GBA,AGER,PDGFA,CYBB,HRAS,APP	6	
Organ Morphology, Organismal Development, Renal and Urological System Development and Function	formation	formation of cast in kidney	8.08E-05	 	 	 	 	HMOX1,PCCA,AGER,GLIS2,ARHGDIA,TNS1,APRT,CD151	8	
Inflammatory Response	inflammation	inflammation of body region	8.48E-05	 	-1.161	 	1.027	APOB,AGER,PIK3R1,CA5B,C1QA,HLA-DQB1,APRT,PTPRC,CXCL10,POR,SGPL1,CTSS,GAA,ABCC1,PIK3CG,PNKD,ATF4,TP53,TNFRSF10B,FGFR2,IRF5,NINJ1,MNT,PSMB2,IL10RA,CTSB,GAPDH,ALDOA,ALCAM,SQSTM1,CYR61,ESR2,C3AR1,GSTP1,LCP2,APOE,FCGRT,ADAM17,GADD45B,DDIT3,HLA-A,HLA-DQA1,ADIPOQ,LGALS9,PPIA,FKBP1A,CD74,ASNS,PIP,UCHL1,CA3,JUN,PTPRJ,MT-CYB,ANXA5,TOP2A,STIM1,ADORA1,NFE2L2,FCGR3A/FCGR3B,CCR1,TYROBP,FCGR2A,EGR1,DGAT2,PLA2G2A,APP,ITGB2,NR4A2,GLIS2,SREBF2,TREM2,PPT1,FCER1G,MS4A2,NR5A2,P2RY12,ARHGDIA,SOCS3,TRAF3,CD4,MBP,LHCGR,TLR8,FCER1A,TYMP,STARD7,HSPA5,TUBB,CD28,CTSD,HS6ST1,ENTPD5,IFI30,CYBB,NEO1,STAB1,ANXA7,RET,LANCL1,TOP3B,MIF,IL2RG,SPP1,RAC1,HNRNPAB,CAPG,KLF4,PKN1,EFS,PREX1,IL1RN,MAPT,NAGLU,CD14,INSR,CST6,TNS1,CD151,SCD,LITAF,LEP,F2RL3,CD2,PKM,HIF1A,IL17RA,FAS,IRAK1,TNFRSF12A,SLC19A3,HMOX1,ALDH2,EDN1,TIMP1,THBS1,ANXA1,DUSP10,KIT,S100A8,CFH,STAT1,MAPKAPK2,NLRC4,VCAM1,NPY1R,NQO1,MAPK9,SOD1,CSF1R,NFE2L1,CXCL16,ENO1,PSMD2,C6,P2RX7	156	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	migration	migration of granulocytes	8.86E-05	 	1.251	bias	-0.791	PLCB2,LEP,AGER,PIK3R1,GDF15,CXCL9,IL17RA,FAS,CXCL10,ANXA1,SAA1,PIK3CG,CYBB,NEO1,S100A8,TXN,ADORA1,MAPKAPK2,CCR1,VCAM1,SPP1,RAC1,ENG,SPON2,ITGB2,PREX1,RTN4,SIRPA	28	
Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders	frontotemporal dementia	frontotemporal dementia	8.94E-05	 	 	 	 	GRN,PARK7,C9orf72,CHCHD10,MAPT,VCP,SQSTM1,CSF1R,PRNP,APP	10	
Carbohydrate Metabolism	glycolysis	glycolysis of cells	8.98E-05	 	1.066	bias	0.017	TP53,HK1,PFKFB3,MIF,PFN1,PFKFB1,PKM,PFKL,HIF1A,CISD2,KLF4,BCAT1,CISD1,ENO1,OGT,PGAM1,ENTPD5,GAPDH,ALDOA,INSR,C1QBP,MAPKAPK2,P2RX7	23	
Carbohydrate Metabolism	glycolysis	glycolysis	9.61E-05	 	0.542	bias	-0.622	PFN1,PFKFB1,PIK3R1,PKM,HIF1A,PFKL,CD28,ALDH2,OGT,BCAT1,ENTPD5,PGAM1,C1QBP,MAPKAPK2,TP53,HK1,PFKFB3,MIF,KLF4,CISD2,ENO1,CISD1,ALDOA,GAPDH,INSR,P2RX7	26	
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	cellular infiltration	cellular infiltration by mononuclear leukocytes	9.74E-05	 	1.459	 	0.664	APOE,TGFBR1,HLA-A,PIK3R1,UNC5B,CTSG,HYOU1,HRAS,CXCL9,IL17RA,FAS,CXCL10,CD28,HMOX1,TIMP1,PIK3CG,SAA1,STAT1,KRT10,GJB2,TP53,CCR1,MIF,VCAM1,UCP2,APP,CXCL16,EFS,GLIS2,NR4A1,C6,ESR2,P2RX7	33	
Cell-To-Cell Signaling and Interaction, Inflammatory Response	immune response	immune response of antigen presenting cells	9.74E-05	Increased	3.833	bias	2.108	GAB2,SOCS3,AGER,ERN1,CD74,BIN1,FAS,PTPRC,HMOX1,PTPRJ,CTSS,THBS1,ANXA1,SAA1,MAPKAPK2,EIF2AK1,PTX3,SIGLEC1,MIF,UCP2,FCGR2A,CAPG,CMC2,APP,ISG15,ITGB2,CD68,TREM2,FCER1G,IL10RA,CD14,SIRPA,P2RX7	33	
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response	immune response	immune response of neutrophils	9.86E-05	Increased	2.573	bias	1.112	TP53,PTX3,VCAM1,AGER,TYROBP,FCGR2A,FCER1A,CXCL10,ITGB2,THBS1,PIK3CG,SAA1,TREM2,FCER1G,STIM1,IGHA1,CLCN3,FCGR3A/FCGR3B	18	
Cancer, Organismal Injury and Abnormalities, Respiratory Disease	metastatic non-small-cell lung cancer	metastatic non-small-cell lung cancer	9.86E-05	 	 	 	 	NDUFB4,TUBB4B,EPB41L4B,TUBG1,TUBB2A,PPIA,RNASE1,ATIC,FAS,FTL,TOP2A,IFI30,TUBA1C,INSR,RET,CLCN3,TMSB10/TMSB4X,MYL12A	18	
Cell Death and Survival	apoptosis	apoptosis of myeloid cells	9.91E-05	 	-0.239	 	-0.335	APOE,ADAM17,LEP,DDIT3,MSR1,FCER1A,LGALS9,C1QA,HIF1A,PDGFC,FAS,ANXA1,CYBB,S100A8,STAT1,HCAR2,NFE2L2,TP53,MIF,NQO1,MAPK9,HAX1,TPSAB1/TPSB2,APP,ISG15,FOS,ITGB2,IL1RN,FCER1G,MS4A2,CD14,PIK3AP1,C3AR1,P2RX7	34	
Neurological Disease	amyotrophic lateral sclerosis	amyotrophic lateral sclerosis	9.97E-05	 	 	 	 	APOE,SLC1A4,PFN1,C9orf72,CHCHD10,TCEA1,CCT2,SLC1A3,ZNF91,PDGFC,FAS,SUSD1,FADS3,NNMT,TIMP1,ANXA1,ANXA5,VCP,ALDH5A1,SLC7A6,PRNP,TP53,SCN2A,SIGMAR1,FUCA1,SOD1,APP,GRN,CALM1 (includes others),SREBF2,FMN2,RTN4,TSPO,PSAP,SLC1A2,CAPN2,SQSTM1,CYR61,ADRA1A	39	
Cellular Function and Maintenance, Small Molecule Biochemistry	homeostasis	homeostasis of inorganic cation	1.00E-04	 	 	 	 	APOE,SLC24A2,SLC31A1,AGER,ARF1,FGF2,SMPD1,HIF1A,HSPA5,SLC9A1,MAFG,CXCL10,HMOX1,CAMK2D,PLCE1,STC2,KCNMA1,ITGAV,NEO1,ANXA7,SLC40A1,PRNP,CCR1,EIF2AK1,TP53,SIGMAR1,SLC24A3,SLC39A6,STOML2,SOD1,APP,FTL,APLP2,MAPT,COMMD1,FECH,ATOX1,ATP6V1B2	38	
Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease	urinary tract cancer	urinary tract cancer	1.01E-04	 	0.785	 	1.061	WHSC1,AGER,PCLO,PIK3R1,VAC14,PLEKHM2,POLRMT,CLIP1,ODC1,NPL,POR,GNB1,CCND3,AJUBA,GLB1,KEAP1,SPTB,DEFB132,TP53,SLC2A5,LCP1,RHEB,PPP1R1B,PAQR3,CARMIL1,FGFR2,LARP4,ANXA2,IRF5,RCC2,BTG2,ESR2,EPHX1,CD163L1,NME1,PSMD7,OSGIN1,FGF2,CUBN,EEF1B2,MFSD5,LAMP3,ACSS3,TNXB,PLIN2,ATP5J2,ALPK2,ADORA1,NFE2L2,ALDH5A1,S100A1,CCR1,SRA1,TUBB4B,DGAT2,LZTS2,ENG,SNCG,FOS,AFF3,FLNC,MBD3,PSAP,C6orf62,SOX9,HAGH,SESN2,ATP2B1,ABCA3,MBP,TLR8,DIRAS1,INTS1,LHFPL2,HS6ST1,KRTAP4-6,MOCOS,TUBA1C,IL2RG,RILPL1,STK39,SRPRB,DMTN,GUF1,FOSB,SDCBP,NDUFA6,HSPB1,CALHM2,FOXRED2,SCD,PTGFR,SLC1A4,FAT3,ALAS1,IL17RA,HNRNPK,IRAK1,TIMP1,SAA1,PPP1R2,LOC102724428/SIK1,CFH,FAM171B,MT-ND6,NPY1R,TUBG1,NQO1,HPS1,G6PD,PYGB,NMT2,PDLIM4,ATIC,CXCL16,PSMD2,SLC25A5,TMEM266,SLC29A4,TOR1A,HRAS,HLA-DQB1,MKI67,SCYL2,PIK3CG,POU6F2,KIF21A,HADHB,NANOS1,TUBB2A,NINJ1,CCND2,ZNF672,IL10RA,ARHGAP35,SFRP1,AIDA,TCF7,CYR61,GSTP1,S100A11,HIST1H1C,ADAM17,BTG3,HLA-A,DUSP6,OXLD1,FKBP1A,XPOT,ATP6AP1,UCHL1,CADM2,JUN,MT-CYB,ANXA5,TOP2A,TRIM16,RPS12,GJB2,MBOAT7,CD53,CD209,SIGLEC1,PLXNA1,MT-ND4,ATXN2L,COL5A3,MRPL51,SNRPC,SREBF2,SBF1,GABARAP,XPO5,ZNF91,TUBB,GSPT1,TMEM230,COMT,SIAH2,RET,MFSD3,ACSL3,SPP1,TRIOBP,ANLN,GPAA1,TPSAB1/TPSB2,SIPA1L1,EVI2B,IL1RN,FMN2,SDHB,PKM,HIF1A,FAM171A2,HMOX1,SLFN5,PCK2,FLNA,KCNMA1,THBS1,KIT,ASAP3,ADCY2,FRMD1,TPST2,AP3D1,PHLDA3,NXPH4,GUK1,CSF1R,TRPM6,MT-ND5,GBE1,MZT2B,DHRS7B	216	
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	colony formation	colony formation of tumor cells	1.02E-04	 	-1.257	 	-0.949	TP53,FOS,LEP,IL1RN,TGFB2,CTSB,BAMBI,LZTS2,RHOBTB2,SFRP1,HIF1A,SQSTM1,HDGF	13	
Hematological System Development and Function, Tissue Morphology	quantity	quantity of mononuclear leukocytes	1.03E-04	Increased	2.050	bias	-0.368	TGFBR1,PIK3R1,MAF,HRAS,SLC35C1,HLA-DQB1,EEF1D,CXCL10,PTPRC,CHST2,SGPL1,ZBTB7B,LGMN,CCND3,CTSS,PIK3CG,ST6GALNAC2,STAM,APEX2,TP53,LAIR1,FGFR2,TSPAN33,HAX1,ARHGDIB,MNT,IL10RA,B3GNT5,ESR2,C3AR1,GSTP1,LCP2,BANK1,APOE,PIM3,GADD45B,DDIT3,HLA-A,PSMB10,ADIPOQ,HLA-DQA1,PPIA,CD74,PTPRJ,SORBS1,SLC19A1,CCR1,SIGLEC1,TYROBP,FCGR2A,IGKC,GNA12,EGR1,APP,ISG15,FOS,ITGB2,FCER1G,NR4A1,PSAP,ARHGDIA,SOCS3,TRAF3,CD4,MBP,LHCGR,STARD7,CD28,CTSD,COMT,STAB1,MIF,IL2RG,SPP1,RAC1,FYB,KLF4,PKN1,FOSB,ACKR3,SH2B3,PIK3AP1,SIRPA,LEP,CD83,DMD,HIF1A,IL17RA,FAS,IRAK1,HLA-G,THBS1,SAA1,DUSP10,KIT,STAT1,PRNP,VCAM1,NPY1R,NQO1,ST3GAL6,VSIG4,MAPK9,SOD1,KIFAP3,IL20RB,CSF1R,CXCL16,LGALS2,PAG1,P2RX7,CARM1	112	
Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development	accumulation	accumulation of neutrophils	1.05E-04	 	1.656	bias	0.602	PTX3,MIF,FCGR2A,EGR1,CTSG,FGFR2,IRF5,IL17RA,GRN,CXCL10,ITGB2,EDN1,IL1RN,ANXA1,S100A8,FCGR3A/FCGR3B,NLRC4	17	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	breast cancer	stage 2-3 breast cancer	1.05E-04	 	 	 	 	KRT14,NME1,SLC9A3R1,LHCGR,NME2,FGFR2,KRT5,HMOX1,FIS1,JUN,C19orf53,KIT,AIDA,LYPLA1,CBX3,ESR2,GJB2	17	
Cellular Function and Maintenance, Small Molecule Biochemistry	homeostasis	homeostasis of divalent cations	1.07E-04	 	 	 	 	APOE,SLC24A2,SLC31A1,AGER,ARF1,FGF2,SMPD1,HSPA5,CXCL10,HMOX1,PLCE1,STC2,KCNMA1,ITGAV,NEO1,ANXA7,SLC40A1,PRNP,TP53,CCR1,EIF2AK1,SIGMAR1,SLC24A3,SLC39A6,STOML2,SOD1,APP,FTL,APLP2,MAPT,FECH,COMMD1,ATOX1	33	
Cell Death and Survival, DNA Replication, Recombination, and Repair	fragmentation	fragmentation of DNA fragment	1.09E-04	 	1.062	 	0.475	LEP,UBQLN1,DNASE1L3,PAM16,SOD1,TPSAB1/TPSB2,FAS,APP,ENO1,MAPT,KEAP1,RTN4,NACC1,CAPN2	14	
Neurological Disease	neurological disorder	late-onset neurological disorder	1.09E-04	 	 	 	 	GAB2,APOE,TYROBP,SLC12A2,HEXA,SOD1,ARSA,BIN1,MT-ND1,NR4A2,GBA,PARK7,MAPT,MS4A4A	14	
Cellular Function and Maintenance, Molecular Transport, Small Molecule Biochemistry	homeostasis	homeostasis of transition metal ion	1.09E-04	 	 	 	 	EIF2AK1,SLC31A1,ARF1,SLC39A6,SOD1,HIF1A,APP,HMOX1,FTL,APLP2,COMMD1,NEO1,FECH,SLC40A1,ATOX1,PRNP	16	
Cell Death and Survival	killing	killing of bacteria	1.09E-04	Increased	2.486	bias	0.593	TP53,LEP,AGER,RAB7A,CTSG,VSIG4,SMPD1,HIF1A,PLA2G2A,CXCL10,CTSD,PI3,LYZ,CTSS,CXCL14,CYBB	16	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	thyroid cancer	thyroid cancer	1.09E-04	 	 	 	 	S100A11,RAP2A,FCGRT,SOCS3,TGFBR1,FGF2,UNC5B,FLRT1,GDF15,PKM,HRAS,PTPRC,POR,KRTAP4-6,TIMP1,THBS1,SRGAP1,TOP2A,KIT,MT-CO3,ARHGEF2,TUBA1C,TPO,RET,MT-ND2,AMOT,TENM2,TP53,SPP1,TUBB4B,TUBG1,TUBB2A,RAC1,MT-ND4,FGFR2,ENG,ATP6V1A,CSF1R,NDUFA13,CXCL16,MT-ND1,MT-ND5,CLGN,CCND2,MBD4,MT-ND3,INSR,ABCC3	48	
Carbohydrate Metabolism, Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	concentration	concentration of phosphatidic acid	1.10E-04	Increased	2.760	bias	1.581	CERS6,SCD,APOE,SPP1,LEP,ARF1,PIK3R1,ABCA3,VAC14,HRAS,SMPD1,HIF1A,NRBF2,FAS,THRSP,SLC3A2,APP,CERS2,HINT1,DGKQ,PIP5K1C,PIK3CG,ANXA5,FCER1G,CD14,INSR,PI4KA,MBOAT7	28	
Molecular Transport	transport	transport of ion	1.12E-04	 	1.938	bias	-0.468	PER1,PLCB2,SLC31A1,YWHAH,ATP5D,KCND3,AHCYL1,ATP2B1,MCUR1,ATP5L,PANX1,SLC9A1,CXCL10,CAMK2D,PXK,ABCC1,SLC7A5,CLCN3,SLCO2B1,SFRP4,MIF,CFL1,STK39,SLC24A3,ASNA1,STOML2,SLC39A3,SLC38A3,KCNG1,RAMP3,ATOX1,VDAC1,STEAP3,ARL2,ATP6V0C,SLC24A2,FHL1,SLC1A4,ATP6V0B,LEP,SLC4A2,FGF2,SLC30A2,RAMP2,ATP6AP1,FAS,CLCN4,EDN1,MT-CYB,KCNMA1,SLC40A1,STIM1,BCAP31,SCNN1B,ADORA1,CCR1,SCN2A,LETM1,SLC9A3R1,AP3D1,SLC12A2,TRPA1,KCNJ3,KCNQ4,ANO2,ATP6V1E1,TRPM6,KIF5B,FKBP4,TSPO,P2RY12,SLC1A2,TTYH3,ABCC3,P2RX7,ATP6V1B2	76	
Small Molecule Biochemistry	metabolism	metabolism of porphyrin	1.13E-04	Increased	2.424	bias	1.385	EIF2AK1,POR,ABCB6,HMOX1,UROS,SPTB,TSPO,FECH,ALAS1,NFE2L2,NFE2L1,APP	12	
Cancer, Organismal Injury and Abnormalities, Reproductive System Disease	growth	growth of mammary tumor	1.16E-04	 	1.008	 	0.333	TP53,SPP1,LEP,AGER,ADIPOQ,HRAS,MKI67,HIF1A,CISD2,RPS4X,NELFE,S100A7,FOS,CISD1,CCND3,SIAH2,CYR61,RET,STAT1,CST6,ESR2,CD151	22	
Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities	cold thyroid nodule	benign cold thyroid nodule	1.17E-04	 	 	 	 	PARK7,PRDX5,ANXA5,CTSB,TPO,GSTP1,APP	7	
Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function	proliferation	proliferation of mononuclear leukocytes	1.17E-04	 	1.281	 	-0.173	TGFBR1,AGER,PIK3R1,MAF,NCSTN,HLA-DQB1,PTPRC,ZBTB7B,CCND3,PIK3CG,ST6GALNAC2,STAM,TXN,AIF1,ZBTB16,TP53,LCP1,LAIR1,TNFRSF10B,HMGA1,CTPS1,ARHGDIB,MNT,HSPA8,CCND2,PIP5K1C,IL10RA,B3GNT5,TCF7,GSTP1,LCP2,BANK1,APOE,PIM3,GADD45B,LAPTM5,PSMB10,ADIPOQ,HLA-DQA1,LGALS9,PPIA,FKBP1A,CD74,JUN,PTPRJ,STIM1,TPO,FCGR3A/FCGR3B,CD209,SIGLEC1,TYROBP,FCGR2A,IGKC,EGR1,ISG15,ITGB2,FOS,FTL,FCER1G,PEA15,ARHGDIA,GAB2,SOCS3,TRAF3,PLCB2,CD4,MBP,CSNK1A1,HSPA5,CD28,CTSD,RHOG,HOXA10,C1QBP,TBC1D10C,IL2RG,MIF,SPP1,FYB,KLF4,PKN1,SLC3A2,EFS,IL1RN,SH2B3,CD14,PIK3AP1,CD151,LEP,CD2,CD83,HIF1A,FAS,HLA-G,HMOX1,THBS1,DUSP10,ANXA1,TGFB2,KIT,STAT1,PRNP,VCAM1,CD160,NPY1R,MAPK9,VSIG4,IL20RB,CSF1R,SHB,PAG1,NCKAP1L,P2RX7	113	
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking	recruitment	recruitment of granulocytes	1.19E-04	 	1.323	bias	-0.617	APOE,ADAM17,KDM6B,LEP,PIK3R1,GDF15,CTSG,CXCL9,IL17RA,CXCL10,CD28,LYZ,EDN1,THBS1,ANXA1,PIK3CG,S100A8,FCGR3A/FCGR3B,CCR1,PTX3,MIF,VCAM1,SPP1,FCGR2A,ST3GAL6,RAC1,ALOX5AP,FLOT1,TPSAB1/TPSB2,SPON2,ITGB2,PREX1,PIP5K1C,IL1RN,RTN4,CD14,SFRP1,C3AR1	38	
Cellular Movement	invasion	invasion of tumor cell lines	1.19E-04	Increased	3.704	bias	0.953	WHSC1,KDM6B,AGER,SLC9A1,CTSS,PIK3CG,KEAP1,ARHGEF26,TMSB10/TMSB4X,WNT5B,TP53,LCP1,FGFR2,HMGA1,HAX1,CTSB,ALCAM,SFRP1,SQSTM1,LYPLA1,CYR61,ESR2,NME1,ADAM17,GBP1,FGF2,DUSP6,GDF15,ADIPOQ,ENAH,S100A7,CA3,JUN,DAB2,ASPH,CCR1,PTPRK,GNA12,EGR1,IPO7,SNCG,APP,GRN,ITGB2,NR4A2,NTRK3,WBP2,ARHGDIA,SOX9,GAB2,SEPT9,UNC5B,NME2,SDC4,CTBP1,CTSD,ENTPD5,ITGAV,MIF,SPP1,GSDMB,PCSK6,RAC1,HNRNPAB,KLF4,SEL1L,SDCBP,ADAM12,CAPN2,CST6,HTRA1,ETV5,RPSA,CD151,PEBP1,LEP,PDGFA,PLGRKT,PKM,SMPD1,HIF1A,FAS,CLCN4,HDGF,HMOX1,EDN1,TIMP1,SAA1,ANXA1,VCP,TGFB2,STAT1,MAPKAPK2,ADAMTS15,VCAM1,SLC9A3R1,BHLHE41,SLC12A2,VANGL1,GIT1,SERPINE2,CAPNS1,MAP4K4	103	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders	familial Parkinson disease	familial Parkinson disease	1.22E-04	 	 	 	 	UCHL1,MT-ND6,MT-ND5,NR4A2,PARK7,MAPT,CHCHD2,ATP13A2	8	
Tissue Development	development	development of epithelial tissue	1.23E-04	 	0.727	 	-0.886	HOXB5,TRAF3,TGFBR1,AGER,SEPT9,ABCA3,HRAS,SDC4,ODC1,SPRY4,CXCL10,HSF4,FRAS1,PIK3CG,CYBB,ARHGEF26,GPC1,PPP1CA,TP53,PFKFB3,SPP1,YWHAG,STK39,RILPL1,PAQR3,RAC1,FGFR2,KLF4,ANGPTL1,PDCL3,TINCR,CTSB,LFNG,CYR61,CD151,APOE,NME1,SPRED1,LEP,GBP1,FGF2,PSMB10,ERN1,PKM,ADIPOQ,PPIA,HIF1A,PDGFC,TNFRSF12A,HMOX1,JUN,EDN1,PTPRJ,TIMP1,THBS1,SAA1,TGFB2,KIT,DAB2,S100A8,STAT1,GJB2,PLOD3,THBS4,VCAM1,ADRM1,KRT6B,EGR1,G6PD,MESP1,MAPK9,ENG,CSF1R,EDF1,FGF1,APP,GRN,SLC14A1,NR4A1,SOX9,BMPER	81	
Hematological Disease, Immunological Disease	lymphoproliferative disorder	lymphoproliferative disorder	1.24E-04	 	-1.242	 	-0.685	KLHDC8B,CRYAB,TGFBR1,WHSC1,PCLO,AGER,PIK3R1,RRM2B,LRRC1,CTSG,CXCL9,POLRMT,CLIP1,ODC1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,FRAS1,STAM,MYBBP1A,TMSB10/TMSB4X,MGAT1,UNG,TP53,RBM38,RHEB,LAIR1,BCOR,ICT1,TNFRSF10B,PPTC7,CARMIL1,MSMO1,FGFR2,ANXA2,CD52,MYL9,CYP4B1,BTG2,DUSP4,LYPLA1,ACTG1,ESR2,RPL41,STEAP3,LMBRD2,MT-TL1,EPHX1,APOE,NME1,GJB6,GADD45B,FGF2,CUBN,DPM2,GDF15,EEF1B2,ADIPOQ,PPIA,CRAT,CD74,COL16A1,ANKRD53,ADORA1,AMOT,KRT10,FCGR3A/FCGR3B,SIGMAR1,RPL4,MT-TY,FCGR2A,TUBB4B,RNF157,STON1,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,ST20,FAM129A,KRT6A,RPL37,STK31,BMPER,ABCC3,CSTF3,CYP4F11,ADRA1A,TRAF3,SESN2,TLR8,HSPA5,NNMT,CD28,KRTAP4-6,TMEM132C,HSF4,SAE1,CYP3A5,EIF3D,RPS13,HOXA7,STAB1,TUBA1C,MTMR2,CNTNAP1,ADAMTS5,NSMAF,PFKFB3,IL2RG,UROS,FYB,TXNRD1,SDCBP,TLN2,ADAM12,SLC25A39,CAPN2,PIK3AP1,INSR,KCTD19,CCPG1,TNS1,UBE2I,HSPB1,RPSA,IGFBP4,SYCE1,RPLP1,MSR1,DENND4B,MECR,BARD1,FAT3,ALAS1,COL6A6,IRAK1,HLA-G,EDN1,TIMP1,PPP1R2,ADCK3,KLHL42,CFH,STOX1,STAT1,LONP1,ATP13A2,MT-CO1,MT-ATP6,SLC12A2,TUBG1,NQO1,ST3GAL6,TRPA1,GIT1,ATIC,CXCL16,PSMD2,EIF3I,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,ITSN1,RAN,NCSTN,MKI67,MT-CO2,HLA-DQB1,CECR1,CXCL10,BCAT1,ZBTB7B,SGPL1,TMEM268,LGMN,MPV17L2,CTSS,GAA,ABCC1,PIK3CG,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,UBXN6,CFL1,SLC24A3,TUBB2A,HMGA1,CTPS1,MNT,ACAD11,CCND2,CD68,PSMB2,CNTNAP4,C19orf53,STIP1,ORC5,ARHGAP35,TCF7,CYR61,RORB,LCP2,GSTP1,HIST1H1C,MSC,SLC24A2,ADAM17,PSMB10,HLA-A,ST6GALNAC4,FKBP1A,KAZN,RPL35,LYZ,JUN,MYO5C,MT-CYB,ANXA5,HLA-DRA,TOP2A,LAMP1,SLC19A1,MT-CO3,STIM1,NPTXR,RPS12,LIMCH1,RPS24,RPS19,SIGLEC1,PTPRK,SYNGR2,EGR1,EPB41L4B,TRIM28,MT-ND4,STXBP6,STS,ITGB2,MRPL51,PSME1,PDIA6,UQCR10,USP22,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,RPS23,CLTB,LHCGR,TCEB2,ZNF91,UBA2,CTBP1,NARS,SLC25A6,DPP3,COMT,KPNA2,ANXA7,RET,EIF2AK1,MIF,SPP1,C5orf15,ANLN,RAC1,HIST1H2BK,ATP10A,MARS,RPL28,SIPA1L1,IL1RN,SH2B3,FMN2,CD14,GNL3,LFNG,RPS15A,CYP4A11,UBE2J2,STMN2,SLC30A2,HIF1A,RPS4X,FAS,ERV3-1,MPEG1,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,VCP,KIT,ASAP3,ALPL,ADAMTS15,PSMB4,TMEM220,SCN2A,COL5A2,CD160,TPST2,CSF1R,KIAA1683,KCNQ4,TRPM6,MT-ND5,PAG1,EPHB3,SLC1A2,SEMA4B,ATP6V1B2,SHMT2	334	
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	accumulation	accumulation of lipid	1.25E-04	 	-0.195	 	-0.403	PAFAH1B2,SCD,APOE,PER1,SDHB,APOB,PLIN1,LEP,MSR1,ADIPOQ,HEXA,SMPD1,CD74,TAF10,H2AFZ,FAS,ODC1,HMOX1,SHTN1,GBA,EDN1,TIMP1,GLB1,PIK3CG,ABCC1,SAA1,PLIN2,PLIN5,LAMP1,CFH,NFE2L2,GULP1,TP53,CERS6,MIF,UCP2,ACP2,FCGR2A,GM2A,ARSA,APP,LAMP2,IL1RN,SREBF2,APOC1,PSAP,INSR,PLTP,C3AR1,NPC2	50	
Molecular Transport	export	export of metal	1.27E-04	 	1.453	bias	0.054	PLCB2,LETM1,FGF2,FAS,APP,CXCL10,HMOX1,MAPT,SLC40A1,ATOX1,SCNN1B,P2RX7,FTH1	13	
Tissue Development	accumulation	accumulation of cells	1.28E-04	 	0.485	 	-0.327	CRYAB,PFN1,SEPT9,AGER,CTSG,NCSTN,CXCL10,CD28,HS6ST1,PIK3CG,CYBB,RET,TP53,PTX3,IL2RG,MIF,SPP1,FGFR2,IRF5,TXNRD1,IL1RN,ACKR3,IL10RA,APOE,DDIT3,F2RL3,FGF2,HS2ST1,ADIPOQ,IL17RA,FAS,HMOX1,EDN1,THBS1,TIMP1,ANXA1,CCL28,KIT,S100A8,STAT1,FCGR3A/FCGR3B,NLRC4,CCR1,VCAM1,TYROBP,FCGR2A,EGR1,MAPK9,ENG,SOD1,FGF1,GRN,ITGB2,CXCL16,NR4A1,SOX9,C6,P2RX7	58	
Cardiovascular System Development and Function, Cellular Movement	migration	migration of endothelial cells	1.28E-04	 	1.988	bias	-0.263	CRYAB,TGFBR1,HRAS,SDC4,HSPA5,CD63,SPRY4,PIK3CG,ITGAV,STAB1,CDC42EP1,GPC1,TMSB10/TMSB4X,SFRP4,SPP1,PAQR3,RAC1,ANXA2,TARS,ANGPTL1,ACKR3,RTN4,ALCAM,CYR61,HSPB1,CD151,APOE,LEP,FGF2,PKM,ADIPOQ,HIF1A,TNFRSF12A,EDN1,FLNA,THBS1,TIMP1,SAA1,TGFB2,MAPKAPK2,AMOT,NFE2L2,PLXNA1,VCAM1,G6PD,ENG,PLXND1,S100A2,FGF1,GRN,ITGB2,WARS,CXXC5,NR4A1	54	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	hematological neoplasia	hematological neoplasia	1.30E-04	 	-1.518	 	-0.960	KLHDC8B,CRYAB,TGFBR1,WHSC1,PCLO,PIK3R1,RRM2B,LRRC1,CTSG,CXCL9,POLRMT,CLIP1,ODC1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,FRAS1,STAM,MYBBP1A,TMSB10/TMSB4X,MGAT1,UNG,TP53,RBM38,RHEB,LAIR1,BCOR,ICT1,TNFRSF10B,PPTC7,CARMIL1,MSMO1,FGFR2,ANXA2,CD52,MYL9,CYP4B1,BTG2,DUSP4,LYPLA1,ACTG1,ESR2,RPL41,STEAP3,LMBRD2,MT-TL1,EPHX1,NME1,GJB6,GADD45B,FGF2,CUBN,DPM2,GDF15,EEF1B2,ADIPOQ,PPIA,CRAT,CD74,COL16A1,ANKRD53,ADORA1,AMOT,KRT10,FCGR3A/FCGR3B,SIGMAR1,RPL4,MT-TY,FCGR2A,TUBB4B,RNF157,STON1,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,ST20,FAM129A,KRT6A,RPL37,STK31,BMPER,ABCC3,CSTF3,CYP4F11,ADRA1A,TRAF3,SESN2,TLR8,HSPA5,NNMT,CD28,KRTAP4-6,TMEM132C,HSF4,SAE1,CYP3A5,EIF3D,RPS13,HOXA7,STAB1,TUBA1C,MTMR2,CNTNAP1,ADAMTS5,NSMAF,PFKFB3,IL2RG,UROS,FYB,TXNRD1,SDCBP,TLN2,SLC25A39,CAPN2,PIK3AP1,INSR,KCTD19,CCPG1,TNS1,UBE2I,HSPB1,RPSA,IGFBP4,SYCE1,RPLP1,MSR1,DENND4B,MECR,BARD1,FAT3,ALAS1,COL6A6,IRAK1,HLA-G,EDN1,TIMP1,PPP1R2,ADCK3,KLHL42,CFH,STOX1,STAT1,LONP1,ATP13A2,MT-CO1,MT-ATP6,SLC12A2,TUBG1,NQO1,ST3GAL6,TRPA1,GIT1,ATIC,CXCL16,PSMD2,EIF3I,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,ITSN1,RAN,NCSTN,MKI67,MT-CO2,HLA-DQB1,CECR1,CXCL10,BCAT1,ZBTB7B,SGPL1,TMEM268,LGMN,MPV17L2,CTSS,GAA,ABCC1,PIK3CG,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,UBXN6,CFL1,SLC24A3,TUBB2A,HMGA1,CTPS1,MNT,ACAD11,CCND2,CD68,PSMB2,CNTNAP4,C19orf53,STIP1,ORC5,ARHGAP35,TCF7,CYR61,RORB,LCP2,GSTP1,HIST1H1C,MSC,SLC24A2,ADAM17,PSMB10,HLA-A,ST6GALNAC4,FKBP1A,KAZN,RPL35,LYZ,JUN,MYO5C,MT-CYB,ANXA5,HLA-DRA,TOP2A,LAMP1,SLC19A1,MT-CO3,STIM1,NPTXR,RPS12,LIMCH1,RPS24,RPS19,SIGLEC1,PTPRK,SYNGR2,EGR1,EPB41L4B,TRIM28,MT-ND4,STXBP6,STS,ITGB2,MRPL51,PSME1,PDIA6,UQCR10,USP22,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,RPS23,CLTB,LHCGR,TCEB2,ZNF91,UBA2,CTBP1,NARS,SLC25A6,DPP3,COMT,KPNA2,ANXA7,RET,EIF2AK1,MIF,SPP1,C5orf15,ANLN,RAC1,HIST1H2BK,ATP10A,MARS,RPL28,SIPA1L1,IL1RN,SH2B3,FMN2,CD14,GNL3,LFNG,RPS15A,CYP4A11,UBE2J2,STMN2,SLC30A2,HIF1A,RPS4X,FAS,ERV3-1,MPEG1,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,VCP,KIT,ASAP3,ALPL,ADAMTS15,PSMB4,TMEM220,SCN2A,COL5A2,CD160,TPST2,CSF1R,KIAA1683,KCNQ4,TRPM6,MT-ND5,PAG1,EPHB3,SLC1A2,SEMA4B,ATP6V1B2,SHMT2	331	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of ceramide	1.30E-04	 	1.203	bias	0.341	CERS6,SCD,LEP,FGF2,ADIPOQ,SMPD1,DEGS1,FAS,CERS2,APP,SGPL1,GBA,MAPK10,KIT,NSMAF,P2RX7	16	
Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	Charcot-Marie-Tooth disease	Charcot-Marie-Tooth disease	1.33E-04	 	 	 	 	HK1,LITAF,SEPT9,SBF1,YARS,SURF1,RAB7A,HSPB8,GARS,NAGLU,MTMR2,AARS,MARS,HSPB1	14	
Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Tissue Development, Visual System Development and Function	abnormal morphology	abnormal morphology of cornea	1.33E-04	 	 	 	 	KRT14,ADAM17,COL5A2,DPT,EGR1,COL8A1,SOD1,CSTB,THBS1,CDC14B,TGFB2,PSAP,PLTP,STAT1	14	
Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities	lymphohematopoietic neoplasia	lymphohematopoietic neoplasia	1.37E-04	 	-1.273	 	-0.771	KLHDC8B,CRYAB,TGFBR1,WHSC1,PCLO,PIK3R1,RRM2B,LRRC1,CTSG,CXCL9,POLRMT,CLIP1,ODC1,GNB1,PTPRC,POR,ALPK3,CCND3,GLB1,FRAS1,STAM,MYBBP1A,TMSB10/TMSB4X,MGAT1,UNG,TP53,RBM38,RHEB,LAIR1,BCOR,ICT1,TNFRSF10B,PPTC7,CARMIL1,MSMO1,FGFR2,ANXA2,CD52,MYL9,CYP4B1,BTG2,DUSP4,LYPLA1,ACTG1,ESR2,RPL41,STEAP3,LMBRD2,MT-TL1,EPHX1,APOE,NME1,GJB6,GADD45B,FGF2,CUBN,DPM2,GDF15,EEF1B2,ADIPOQ,PPIA,CRAT,CD74,COL16A1,ANKRD53,ADORA1,AMOT,KRT10,FCGR3A/FCGR3B,SIGMAR1,RPL4,MT-TY,FCGR2A,TUBB4B,RNF157,STON1,IPO7,GRN,MTHFD1L,MT-ND1,RPS16,ALDH1L2,NTRK3,ST20,FAM129A,KRT6A,RPL37,STK31,BMPER,ABCC3,CSTF3,CYP4F11,ADRA1A,TRAF3,SESN2,TLR8,HSPA5,NNMT,CD28,KRTAP4-6,TMEM132C,HSF4,SAE1,CYP3A5,EIF3D,RPS13,HOXA7,STAB1,TUBA1C,MTMR2,CNTNAP1,ADAMTS5,NSMAF,PFKFB3,IL2RG,UROS,FYB,TXNRD1,SDCBP,TLN2,ADAM12,SLC25A39,CAPN2,PIK3AP1,INSR,KCTD19,CCPG1,TNS1,UBE2I,HSPB1,RPSA,IGFBP4,SYCE1,RPLP1,MSR1,DENND4B,MECR,BARD1,FAT3,ALAS1,COL6A6,IRAK1,HLA-G,EDN1,TIMP1,PPP1R2,ADCK3,KLHL42,CFH,STOX1,STAT1,LONP1,ATP13A2,MT-CO1,MT-ATP6,SLC12A2,TUBG1,NQO1,ST3GAL6,TRPA1,GIT1,ATIC,CXCL16,PSMD2,EIF3I,TBC1D7,MAP4K4,RPLP0,TUBA1B,APOB,ITSN1,RAN,NCSTN,MKI67,MT-CO2,HLA-DQB1,CECR1,CXCL10,BCAT1,ZBTB7B,SGPL1,TMEM268,LGMN,MPV17L2,CTSS,GAA,ABCC1,PIK3CG,POU6F2,KIF21A,HADHB,PNKD,RPS2,ZBTB16,UBXN6,CFL1,SLC24A3,TUBB2A,HMGA1,CTPS1,MNT,ACAD11,CCND2,CD68,PSMB2,CNTNAP4,C19orf53,STIP1,ORC5,ARHGAP35,TCF7,CYR61,RORB,LCP2,GSTP1,HIST1H1C,MSC,SLC24A2,ADAM17,PSMB10,HLA-A,ST6GALNAC4,FKBP1A,KAZN,RPL35,LYZ,JUN,MYO5C,MT-CYB,ANXA5,HLA-DRA,TOP2A,LAMP1,SLC19A1,MT-CO3,STIM1,NPTXR,RPS12,LIMCH1,RPS24,RPS19,SIGLEC1,PTPRK,SYNGR2,EGR1,EPB41L4B,TRIM28,MT-ND4,STXBP6,STS,ITGB2,MRPL51,PSME1,PDIA6,UQCR10,USP22,NIPSNAP3A,FCER1G,PRMT5,CYCS,DVL3,CBX4,NCAM1,EFR3A,UBE2A,RPS23,CLTB,LHCGR,TCEB2,ZNF91,UBA2,CTBP1,NARS,SLC25A6,DPP3,COMT,KPNA2,ANXA7,RET,EIF2AK1,MIF,SPP1,C5orf15,ANLN,RAC1,HIST1H2BK,ATP10A,MARS,RPL28,SIPA1L1,IL1RN,SH2B3,FMN2,CD14,GNL3,LFNG,RPS15A,CYP4A11,UBE2J2,STMN2,SLC30A2,HIF1A,RPS4X,FAS,ERV3-1,MPEG1,HMOX1,THBS1,FLNA,KCNMA1,ANXA1,VCP,KIT,ASAP3,ALPL,ADAMTS15,PSMB4,TMEM220,SCN2A,COL5A2,CD160,TPST2,CSF1R,KIAA1683,KCNQ4,TRPM6,MT-ND5,PAG1,EPHB3,SLC1A2,SEMA4B,ATP6V1B2,SHMT2	333	
Cancer, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	muscle tumor	muscle tumor	1.38E-04	 	 	 	 	CPAMD8,KDM6B,APOB,RPE,AHCYL1,ASS1,TOR1A,MAF,LRRC1,HRAS,DDX20,MT-CO2,TMEM184B,MKI67,PTPRC,LGMN,CTSS,PXK,POU6F2,PLEKHO2,PNKD,MYBBP1A,WNT5B,TP53,SLC2A5,RBM38,SFRP4,CAPN6,DPT,PLD3,SLC24A3,TNFRSF10B,TUBB2A,CARMIL1,FGFR2,KAZALD1,HMGA1,AP2S1,ACAD11,CYP4B1,RTN4,ALDOA,ME2,ZNF629,SFRP1,CYR61,MYEOV,ESR2,RORB,UTP18,TRAPPC5,GSTP1,FTH1,S100A11,APOE,ALDH4A1,SLC4A2,FGF2,PHLDA2,GDF15,HYOU1,PFKL,TECR,SDC3,UCHL1,JUN,SORBS1,TOP2A,TRIM16,ACVR1C,RNF135,KRT10,PI4KA,ALDH5A1,FCGR3A/FCGR3B,RPS19,TYROBP,TUBB4B,ALOX5AP,STXBP6,FOS,ITGB2,COL5A3,MYOC,NR4A2,SBF1,NR4A1,NR5A2,P2RY12,CBX4,DCX,ADRA1A,NCAM1,PNO1,SOCS3,MEGF9,AKR1C3,MYH15,TLR8,LHCGR,RAB9A,MMRN1,CTSD,HS6ST1,KRTAP4-6,CNDP2,TMEM132C,DPP3,CXCL14,RPL19,TUBA1C,RET,ADAMTS5,PSMA6,SPP1,ACP2,ATP10A,ARSA,TXNRD1,TPSAB1/TPSB2,DMXL2,PIK3R3,KCNG1,ADAM12,SH2B3,MAPT,NDUFA6,FMN2,CLCN7,INSR,NDUFS3,CCPG1,CYP4A11,SCD,SYCE1,LITAF,MSR1,SLC7A1,SMPD1,RRP36,PDGFC,PLPP1,RAMP2,FAS,VCP,KIT,CFH,STOX1,ALPL,PRNP,THBS4,FRMD1,DLGAP4,TUBG1,DVL1,PYGB,SNX27,CSF1R,SLC5A3,THRSP,CXCL16,TRPM6,RPS15,GIPR,PCCA,GBE1,FECH,MAP4K4,P2RX7	169	
Cardiovascular Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders	myocardial infarction	myocardial infarction	1.38E-04	 	-1.741	 	-1.161	APOE,FGF2,DUSP6,GDF15,ADIPOQ,HIF1A,NNMT,HMOX1,EDN1,CYBB,ITGAV,TUBA1C,GCLM,STAT1,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ATP5J,PTX3,PSMA6,FCGR2A,TUBB4B,TUBG1,TUBB2A,RAC1,F13A1,SOD1,CSF1R,APP,ITGB2,LGALS2,IL1RN,SH2B3,FCER1G,P2RY12,CD14,C6,ADRA1A	39	
Lipid Metabolism, Small Molecule Biochemistry	synthesis	synthesis of D-erythro-C16-ceramide	1.42E-04	Increased	2.000	bias	 	CERS6,GBA,FGF2,SMPD1,CERS2	5	
Protein Degradation, Protein Synthesis	stabilization	stabilization of protein	1.47E-04	 	 	 	 	PFN1,PIK3R1,CCT2,DPM2,SH3GLB1,HSPA5,PARK7,FLNA,IFI30,AAK1,CCT5,LAMP1,ASPH,DPM3,GPR26,VPS11,NACA,TP53,STXBP1,DVL1,PHB2,PSMD8,DSG1,HIST1H1B,SEL1L,HSPA8,CTSA,LAMP2,GAPDH,DVL3	30	
Cardiovascular System Development and Function	morphology	morphology of cardiovascular system	1.47E-04	 	 	 	 	CRYAB,APOB,RRM2B,COL8A1,NCSTN,BIN1,CXCL10,POR,RSPO3,LGMN,PLCE1,RHOG,CCND3,ARID3B,GAA,CYBB,ITGAV,PLIN5,ARHGEF26,ANXA7,SIAH2,RET,MGAT1,TP53,EIF2AK1,RBM38,IL2RG,RHEB,SPP1,SGCG,CSRP2,RAC1,TSPAN33,HMGA1,CCND2,ADAM12,ACKR3,IL1RN,CAPN2,MEGF8,ESR2,STEAP3,LCP2,CD151,APOE,HIST1H1C,PIM3,ADAM17,FGF2,PDGFA,HSPB8,ADIPOQ,SLC7A1,FKBP1A,HIF1A,RAMP2,COL15A1,FAS,CIAPIN1,HMOX1,JUN,EDN1,PTPRJ,THBS1,FLNA,TGFB2,CFH,GNG5,NFE2L2,AMOT,PLOD3,VCAM1,CAPZB,TRIM55,MTMR14,G6PD,MESP1,EMD,MAPK9,ENG,SNX27,KIFAP3,KIF3B,PLXND1,CISD2,APP,CAPNS1,NTRK3,PSAP,GBE1,ARHGDIA,DVL3,NCKAP1L,EFEMP2	94	
Cell Death and Survival	cell death	cell death of breast cancer cell lines	1.48E-04	 	-0.115	 	-0.296	TGFBR1,HSPA5,SLC9A1,ODC1,SLC25A6,KPNA2,MYBBP1A,TP53,MIF,LMO4,TNFRSF10B,RAC1,FGFR2,SDHC,DPH2,CCND2,DUSP4,SFRP1,CYR61,ESR2,HSPB1,FTH1,PEBP1,NME1,NACC2,OSGIN1,FGF2,PKM,BARD1,ADIPOQ,HSPB8,SMPD1,HIF1A,FAS,HMOX1,RABL6,HINT1,JUN,PCK2,THBS1,VCP,TGFB2,DAB2,STAT1,HCAR2,NLRC4,PRNP,NQO1,MAPK9,NDUFA13,PI3,KIFC3,PEA15,CYCS,ARHGDIA	55	

Tox Functions for My Projects->David Bulger->P2
Categories	Functions	Diseases or Functions Annotation	p-Value	Predicted Activation State	Activation z-score	Notes	Bias-corrected z-score	Molecules	# Molecules	
Liver Fibrosis	fibrosis	fibrosis of liver	2.76E-06	 	-1.223	 	-0.442	SOCS3,APOE,SCD,LEP,AGER,DDIT3,SMPD1,CD74,PDGFC,HDGF,HMOX1,JUN,TIMP1,TGFB2,STAB1,STAT1,NFE2L2,TP53,CCR1,MIF,IL2RG,SPP1,FGFR2,NFE2L1,CTSB,NAGLU,GSTP1,HSPB1	28	
Liver Necrosis/Cell Death	cell death	cell death of liver	3.17E-06	 	-1.029	 	-0.030	SCD,APOE,SOCS3,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,FKBP1A,SMPD1,TMBIM6,TAF10,IL17RA,FAS,PTPRC,CXCL10,SLC19A3,HMOX1,ALDH2,JUN,TIMP1,FLNA,ENTPD5,SAA1,ITGAV,CFH,STAT1,NFE2L2,TP53,TYROBP,MAPK9,SOD1,IRF5,NFE2L1,APP,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,CD14,DUSP4,SLC25A5	46	
Liver Necrosis/Cell Death	necrosis	necrosis of liver	1.36E-05	 	-0.859	 	0.115	SCD,APOE,SOCS3,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,FKBP1A,SMPD1,TMBIM6,IL17RA,FAS,PTPRC,CXCL10,SLC19A3,HMOX1,ALDH2,JUN,TIMP1,FLNA,ENTPD5,SAA1,ITGAV,CFH,STAT1,NFE2L2,TP53,TYROBP,MAPK9,SOD1,IRF5,NFE2L1,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,CD14,DUSP4,SLC25A5	44	
Renal Necrosis/Cell Death	cell death	cell death of kidney cells	1.76E-05	 	-0.409	 	-1.538	GFPT1,CRYAB,CCNI,UNC5B,HRAS,HSPA5,SGPL1,RHOG,MCOLN3,ABCC1,ITGAV,NEO1,DPM3,TP53,HK1,SPP1,TNFRSF10B,GNG2,BCL2L14,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,SFRP1,VDAC1,GSTP1,HSPB1,APOE,CD2,DDIT3,ERN1,FGF2,HYOU1,HIF1A,FAS,EDN1,VCP,AAK1,ADORA1,NDUFAB1,NFE2L2,ATP13A2,NLRC4,TMEM123,PRNP,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,GLIS2,NTRK3,SREBF2,PEA15,CYCS,P2RX7	60	
Renal Damage	nephrotoxicity	nephrotoxicity	1.89E-05	 	 	 	 	SLC7A11,SPP1,YWHAH,NQO1,G6PD,GSS,TXNRD1,ODC1,SLC38A3,LYZ,CLDN1,CTSS,TIMP1,BTG2,PSMA3,TMSB10/TMSB4X,ADORA1,GJB2,HAGH,GSTP1,HSPB1	21	
Renal Damage, Renal Tubule Injury	proximal tubular toxicity	proximal tubular toxicity	3.28E-05	 	 	 	 	SPP1,YWHAH,NQO1,G6PD,GSS,TXNRD1,ODC1,SLC38A3,LYZ,TIMP1,CLDN1,CTSS,BTG2,PSMA3,TMSB10/TMSB4X,ADORA1,GJB2,HAGH,GSTP1,HSPB1	20	
Liver Necrosis/Cell Death	cell death	cell death of liver cells	5.85E-05	 	-0.037	 	0.234	SCD,SOCS3,APOE,GADD45B,DDIT3,AGER,PIK3R1,ADIPOQ,HRAS,SMPD1,TMBIM6,FAS,CXCL10,PTPRC,HMOX1,ALDH2,JUN,TIMP1,SAA1,ENTPD5,ITGAV,CFH,STAT1,NFE2L2,TP53,MAPK9,IRF5,RBCK1,MNT,FOS,ITGB2,LAMP2,IL1RN,CTSB,DUSP4,SLC25A5	36	
Renal Necrosis/Cell Death	cell death	cell death of kidney cell lines	7.97E-05	 	-0.005	 	-1.275	CRYAB,UNC5B,HRAS,HSPA5,SGPL1,RHOG,MCOLN3,ABCC1,ITGAV,NEO1,DPM3,HK1,TP53,SPP1,GNG2,BCL2L14,TNFRSF10B,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,VDAC1,GSTP1,HSPB1,CD2,DDIT3,ERN1,HYOU1,FAS,VCP,AAK1,NDUFAB1,NFE2L2,ATP13A2,NLRC4,TMEM123,PRNP,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,SREBF2,NTRK3,PEA15,CYCS,P2RX7	51	
Cardiac Infarction	myocardial infarction	myocardial infarction	1.38E-04	 	-1.741	 	-1.161	APOE,FGF2,DUSP6,GDF15,ADIPOQ,HIF1A,NNMT,HMOX1,EDN1,CYBB,ITGAV,TUBA1C,GCLM,STAT1,ADORA1,MAPKAPK2,HCAR2,FCGR3A/FCGR3B,ATP5J,PTX3,PSMA6,FCGR2A,TUBB4B,TUBG1,TUBB2A,RAC1,F13A1,SOD1,CSF1R,APP,ITGB2,LGALS2,IL1RN,SH2B3,FCER1G,P2RY12,CD14,C6,ADRA1A	39	
Liver Damage	damage	damage of liver	2.37E-04	 	-0.626	 	-0.645	SCD,APOE,LEP,DDIT3,HLA-A,ADIPOQ,LGALS9,FKBP1A,SMPD1,SDC4,FAS,CERS2,PTPRC,CXCL10,POR,HMOX1,ALDH2,JUN,EDN1,TIMP1,GAA,KEAP1,SAA1,HLA-DRA,STAB1,CFH,STAT1,NFE2L2,TP53,MIF,SPP1,EGR1,TNFRSF10B,MAPK9,SOD1,SAA2,ITGB2,IL1RN,CTSB,CD14,INSR,C3AR1,P2RX7,GSTP1	44	
Liver Inflammation/Hepatitis	inflammation	inflammation of liver	3.35E-04	Decreased	-2.190	bias	-0.386	SCD,APOE,TRAF3,LEP,APOB,F2RL3,DDIT3,HLA-A,ADIPOQ,LGALS9,PPIA,FKBP1A,IL17RA,FAS,PTPRC,CXCL10,POR,SLC19A3,HMOX1,PTPRJ,TIMP1,GAA,ENTPD5,STAB1,STAT1,ADORA1,NFE2L2,FCGR3A/FCGR3B,TP53,IL2RG,SPP1,TYROBP,FCGR2A,EGR1,TNFRSF10B,MAPK9,SOD1,NFE2L1,EFS,ITGB2,IL1RN,NAGLU,CD14,INSR,CYR61,GSTP1,LCP2	47	
Increased Levels of LDH	release	increased release of LDH	6.56E-04	 	 	 	 	HMOX1,ITGB2,EDN1,SLC9A1,KLF4,APP	6	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart	7.93E-04	 	-0.068	 	0.293	CRYAB,PFN1,PFKFB1,PIK3R1,HRAS,SLC9A1,EEF1D,CTSD,PLCE1,CAMK2D,GAA,PIK3CG,PLIN5,PNKD,CYBB,TXN,TP53,RHEB,MIF,RAC1,HMGA1,KLF4,LMCD1,MYL9,MNT,MTPN,CTSB,ESR2,APOE,ADAM17,LEP,PDGFA,FGF2,GDF15,ADIPOQ,HSPB8,PPIA,FKBP1A,DMD,HIF1A,PDGFC,H2AFZ,HMOX1,JUN,EDN1,PARK7,TIMP1,SCNN1B,ADORA1,TRIM55,PRMT5,ADRA1A	52	
Liver Damage	injury	injury of liver	8.46E-04	 	-1.396	 	-1.271	SCD,APOE,LEP,DDIT3,HLA-A,ADIPOQ,LGALS9,FKBP1A,SDC4,FAS,POR,CXCL10,PTPRC,HMOX1,ALDH2,EDN1,TIMP1,GAA,SAA1,HLA-DRA,STAB1,CFH,STAT1,NFE2L2,SPP1,EGR1,TNFRSF10B,MAPK9,SOD1,SAA2,ITGB2,IL1RN,CTSB,CD14,INSR,P2RX7	36	
Renal Necrosis/Cell Death	cell viability	cell viability of kidney cell lines	9.25E-04	 	0.927	 	0.110	AGER,FGF2,HYOU1,RAC1,PPIA,APP,SGPL1,ANXA5,MAPT,ITGAV,SLC40A1,RET,ABCC3,VDAC1,P2RX7	15	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of heart	9.90E-04	 	0.892	 	1.700	SOCS3,SCD,CRYAB,LEP,FGF2,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,C1QTNF9,HMOX1,CAMK2D,PARK7,EDN1,CYBB,STAT1,MAPKAPK2,TP53,S100A1,SPP1,RAC1,KIFAP3,PKN1,MTPN,IL1RN,RTN4,GAPDH,CYR61,ADRA1A	31	
Cardiac Necrosis/Cell Death	cell death	cell death of heart	1.04E-03	 	0.341	 	1.264	SOCS3,SCD,CRYAB,LEP,FGF2,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,C1QTNF9,HMOX1,CAMK2D,PARK7,EDN1,TIMP1,CYBB,STAT1,MAPKAPK2,TP53,HK1,S100A1,THBS4,SPP1,RAC1,KIFAP3,PKN1,MTPN,IL1RN,RTN4,GAPDH,CYR61,ADRA1A,RPSA,HSPB1	36	
Cardiac Damage	injury	injury of heart	1.09E-03	 	-1.298	 	-0.632	ALDH2,PIM3,ANXA1,PIK3CG,ADIPOQ,ATF4,MAPK9,TXN,ADORA1,CBR1	10	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of cardiomyocytes	1.10E-03	 	0.598	 	1.374	SOCS3,CRYAB,LEP,FGF2,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,C1QTNF9,HMOX1,CAMK2D,PARK7,EDN1,CYBB,STAT1,MAPKAPK2,TP53,S100A1,SPP1,RAC1,KIFAP3,PKN1,MTPN,IL1RN,RTN4,GAPDH,CYR61,ADRA1A	30	
Cardiac Necrosis/Cell Death	cell death	cell death of cardiomyocytes	1.12E-03	 	0.241	 	1.041	SOCS3,CRYAB,LEP,FGF2,ADIPOQ,CTSG,HSPB8,HIF1A,FAS,IRAK1,C1QTNF9,HMOX1,CAMK2D,PARK7,EDN1,TIMP1,CYBB,STAT1,MAPKAPK2,TP53,S100A1,HK1,SPP1,RAC1,KIFAP3,PKN1,MTPN,IL1RN,RTN4,GAPDH,CYR61,ADRA1A,RPSA,HSPB1	34	
Liver Necrosis/Cell Death	cell death	cell death of hepatocytes	1.38E-03	 	1.060	 	1.259	SOCS3,SCD,GADD45B,DDIT3,PIK3R1,ADIPOQ,HRAS,SMPD1,TMBIM6,FAS,CXCL10,HMOX1,ALDH2,JUN,SAA1,ENTPD5,STAT1,NFE2L2,TP53,MAPK9,IRF5,RBCK1,FOS,IL1RN,CTSB,SLC25A5	26	
Kidney Failure	acute renal failure	acute renal failure	1.45E-03	 	 	 	 	CD28,HMOX1,SLC7A11,SPP1,EDN1,NPR3,TOP2A,CYR61,ADORA1,GSS,ADRA1A,GSTP1	12	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cell lines	1.79E-03	 	0.969	 	-0.075	CD2,DDIT3,UNC5B,HYOU1,HRAS,HSPA5,FAS,SGPL1,RHOG,ABCC1,MCOLN3,ITGAV,DPM3,NFE2L2,NLRC4,TP53,SPP1,GNA12,TNFRSF10B,BCL2L14,GNG2,RAC1,TRIB3,SDHC,HAX1,FGF1,APP,FOS,MYOC,SREBF2,MAPT,PEA15,CYCS,DUSP4,VDAC1,P2RX7,HSPB1	37	
Cardiac Damage	damage	damage of heart	1.81E-03	 	-1.600	bias	-0.574	ALDH2,HMOX1,PIM3,ANXA1,PIK3CG,GDF15,ADIPOQ,CTNNA1,MAPK9,ATF4,TXN,ADORA1,SLC9A1,CBR1	14	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver	2.07E-03	 	-0.448	 	-0.007	TP53,SCD,SOCS3,GADD45B,ADIPOQ,HRAS,MAPK9,SMPD1,TMBIM6,TAF10,IRF5,FAS,NFE2L1,APP,RBCK1,PTPRC,CXCL10,ALDH2,JUN,TIMP1,ENTPD5,SAA1,ITGAV,CTSB,CFH,STAT1	26	
Cardiac Arteriopathy	coronary artery disease	coronary artery disease	2.74E-03	 	 	 	 	APOE,SLC7A11,APOB,ITGA8,CCDC167,ADIPOQ,FKBP1A,SLC9A1,GSS,NNMT,EDN1,SORBS1,THBS1,GAA,ITGAV,TUBA1C,SCNN1B,ADORA1,HCAR2,ALDH5A1,CERS6,COL5A2,SGCG,TUBB4B,TUBG1,TUBB2A,ALOX5AP,SOD1,PLA2G2A,FOS,MCF2L,ITGB2,MTHFD1L,SUPV3L1,LAMP2,NPR3,FMN2,GBE1,CD14,P2RY12,INSR,ESR2	42	
Liver Proliferation	proliferation	proliferation of liver cells	3.15E-03	 	0.932	 	-0.023	SOCS3,LEP,PIK3R1,ADIPOQ,HRAS,SMPD1,ODC1,FAS,TNFRSF12A,JUN,EDN1,CCND3,THBS1,TIMP1,ENTPD5,CXCL14,ITGAV,SLC7A5,STAT1,NFE2L2,TP53,SPP1,MAPK9,FGFR2,FOS,IL1RN,CTSB,INSR,C3AR1	29	
Liver Cirrhosis	primary biliary cirrhosis	primary biliary cirrhosis	3.46E-03	 	 	 	 	APOB,SPP1,SLC4A2,TBC1D9,NQO1,HLA-DQB1,HNRNPK,FGF1,SREBF2,ABCC1,CCL28,HLA-DRA,TGFB2,NR4A1,ABCC3,ALPL	16	
Increased Levels of ALT	localization	increased localization of ALT	3.60E-03	 	 	 	 	APOE,ITGB2,SAA1,SMPD1,C1QA,IL17RA	6	
Liver Damage	drug-induced hepatotoxicity	drug-induced hepatotoxicity	4.39E-03	 	 	 	 	SLC7A11,GSS,FAS	3	
Liver Failure	failure	failure of liver	4.62E-03	 	 	 	 	TP53,HMOX1,ADAM17,SLC7A11,EDN1,TIMP1,TOP2A,MARS,GSS,FAS,ADRA1A	11	
Renal Degeneration	degeneration	degeneration of kidney	6.04E-03	 	-1.633	bias	-0.793	GLIS2,MTSS1,ARHGDIA,SDC4,TNS1,CD151	6	
Renal Damage	drug toxicity-related nephropathy	drug toxicity-related nephropathy	6.27E-03	 	 	 	 	SLC7A11,GSS	2	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells/myofibroblasts	6.27E-03	 	 	 	 	CTSB,SMPD1	2	
Glomerular Injury	glomerular crescent	glomerular crescent	7.64E-03	 	-1.664	bias	-0.663	CCR1,RPS19,HMOX1,MIF,C1QA,CD151	6	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction of heart	8.23E-03	 	 	 	 	SCD,LEP,CYBB,HRAS	4	
Renal Proliferation	growth	arrest in growth of kidney cell lines	8.27E-03	 	 	 	 	TP53,FOS,HRAS	3	
Decreased Levels of Albumin	activation	decreased activation of albumin	8.27E-03	 	 	 	 	TP53,UBA2,UBE2I	3	
Liver Cholestasis	obstructive cholestasis	obstructive cholestasis	8.27E-03	 	 	 	 	CD68,ABCC3,GJB2	3	
Renal Proliferation	cell proliferation	cell proliferation of kidney cell lines	8.53E-03	 	0.032	 	-0.481	SOCS3,SDHB,DUSP6,UNC5B,HRAS,CES2,HSPA4,PLCE1,JUN,RET,NDUFAB1,AMOT,TP53,PFKFB3,FGFR2,CSF1R,FGF1,GRN,FOS,MYOC,SDCBP,ADCY1,RARRES3,VDAC1,PPP2R1B,P2RX7	26	
Liver Cirrhosis	cirrhosis	Cirrhosis	1.03E-02	 	 	 	 	ADAM17,SLC4A2,LEP,APOB,UTP4,HLA-DQB1,HNRNPK,TIMP1,ABCC1,CCL28,HLA-DRA,TOP2A,TGFB2,GCLM,NFE2L2,ALPL,TP53,CCR1,SPP1,TBC1D9,EGR1,NQO1,FGF1,SREBF2,NR4A1,INSR,ABCC3,GSTP1,ADRA1A	29	
Liver Fibrosis	activation	activation of hepatic stellate cells	1.05E-02	 	0.099	bias	-1.097	MIF,LEP,EDN1,AGER,TIMP1,FGF2,BAMBI,STAT1,PDGFC	9	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cells	1.29E-02	 	-0.081	 	0.308	TP53,SCD,SOCS3,GADD45B,ADIPOQ,HRAS,MAPK9,SMPD1,TMBIM6,IRF5,FAS,RBCK1,PTPRC,CXCL10,ALDH2,JUN,TIMP1,ENTPD5,SAA1,ITGAV,CTSB,CFH,STAT1	23	
Increased Levels of Red Blood Cells	quantity	increased quantity of red blood cells	1.32E-02	 	 	 	 	TP53,EIF2AK1,TGFBR1,PIK3R1,MAF,SLC7A1,TSPAN33,SOD1,CIAPIN1,HMOX1,LGMN,CCND2,CCND3,NFE2L2,APEX2	15	
Liver Fibrosis, Liver Proliferation	proliferation	proliferation of hepatic stellate cells	1.56E-02	 	0.691	bias	-0.064	LEP,SPP1,EDN1,TIMP1,CTSB,ADIPOQ,ITGAV,SMPD1,STAT1	9	
Renal Damage	damage	damage of kidney	1.68E-02	 	0.724	 	0.082	TP53,CCR1,APOE,MIF,LEP,FCGR2A,FGF2,UNC5B,RAC1,C1QA,FAS,PREX1,EDN1,THBS1,ARHGDIA,ANXA7,CFH,ADORA1,C3AR1	19	
Increased Levels of Hematocrit	hematocrit	increased hematocrit of organism	1.73E-02	 	 	 	 	TP53,RBM38,APOE,SPP1,DMTN,TSPAN33,NFE2L1,APRT,CIAPIN1,HMOX1,LGMN,ATF4,NFE2L2,STEAP3	14	
Renal Inflammation, Renal Nephritis	Goodpasture's syndrome	Goodpasture's syndrome	1.78E-02	 	 	 	 	DDIT3,ASNS	2	
Liver Steatosis	hepatic steatosis	advanced stage hepatic steatosis	1.78E-02	 	 	 	 	LEP,SPP1	2	
Liver Damage	histopathological change	histopathological change of liver	1.78E-02	 	 	 	 	IL2RG,APP	2	
Renal Dysplasia, Renal Hypoplasia	renal hypodysplasia/aplasia type 1	renal hypodysplasia/aplasia type 1	1.78E-02	 	 	 	 	ITGA8,RET	2	
Cardiac Infarction	acute myocardial infarction	acute myocardial infarction	1.83E-02	 	 	 	 	ATP5J,PTX3,EDN1,FCGR2A,TUBB4B,TUBG1,TUBB2A,ADIPOQ,ITGAV,F13A1,P2RY12,TUBA1C,ADORA1,FCGR3A/FCGR3B,APP	15	
Renal Inflammation, Renal Nephritis	nephrotoxic nephritis	nephrotoxic nephritis	2.05E-02	 	 	 	 	LEP,HLA-DQB1,FCGR3A/FCGR3B	3	
Cardiac Hypertrophy	hypertrophy	hypertrophy of heart cells	2.22E-02	 	-0.546	 	-0.953	CRYAB,LEP,FGF2,GDF15,HSPB8,ADIPOQ,PPIA,DMD,SLC9A1,H2AFZ,EEF1D,LMCD1,MNT,CTSD,CAMK2D,JUN,PLCE1,EDN1,TIMP1,CTSB,PRMT5,ADORA1	22	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatocytes	2.34E-02	 	0.619	 	0.928	TP53,SCD,SOCS3,GADD45B,ADIPOQ,HRAS,MAPK9,SMPD1,TMBIM6,IRF5,FAS,RBCK1,CXCL10,ALDH2,JUN,ENTPD5,SAA1,CTSB,STAT1	19	
Glomerular Injury	formation	formation of glomerular crescent	2.62E-02	 	-1.387	bias	-0.506	CCR1,HMOX1,MIF,C1QA,CD151	5	
Liver Necrosis/Cell Death	cell death	cell death of liver cell lines	2.78E-02	 	-0.126	 	-0.513	TP53,LAMP2,GADD45B,JUN,TIMP1,DUSP4,FAS	7	
Liver Hyperplasia/Hyperproliferation	quantity	quantity of liver tumor	2.90E-02	 	 	 	 	TP53,JUN,LEP	3	
Cardiac Necrosis/Cell Death	apoptosis	apoptosis of ventricular myocytes	3.24E-02	 	1.353	 	1.480	TP53,S100A1,RAC1,ADIPOQ,RTN4,ADRA1A	6	
Glutathione Depletion In Liver	quantity	quantity of glutathione in liver	3.31E-02	 	1.000	 	0.543	LEP,AGER,NFE2L2,CERS2	4	
Cardiac Arrythmia	arrhythmia	arrhythmia	3.35E-02	 	0.066	 	0.337	PTGFR,KCND3,SNTA1,HRAS,DMD,KCNMA1,TIMP1,PIK3CG,ANXA7,TUBA1C,TXN,ASPH,ADORA1,PPP1CA,PI4KA,SLC2A5,VCAM1,TUBB4B,TUBG1,TUBB2A,RAC1,DGAT2,CALM1 (includes others),P2RY12,NHLH1,P2RX7,ADRA1A,LCP2	28	
Liver Hyperplasia/Hyperproliferation	liver cancer	early stage liver cancer	3.38E-02	 	 	 	 	FOS,JUN	2	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal tubule	3.38E-02	 	 	 	 	GLIS2,APRT	2	
Liver Cholestasis	lipopolysaccharide hepatocellular cholestasis	lipopolysaccharide hepatocellular cholestasis	3.38E-02	 	 	 	 	CD68,GJB2	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	hepatocellular carcinoma	3.38E-02	 	-0.178	 	0.204	MVD,SOCS3,PLCB2,KCTD2,APOB,WHSC1,PFN1,ARF1,PIK3R1,ARPC5,LRRC1,HRAS,GHITM,TYMP,ZNF91,HSPA5,BIN1,NNMT,POR,CTSD,DYNLL1,DPP3,KEAP1,ENTPD5,NUPR1,STAB1,ANXA7,TXN,MYBBP1A,RET,TP53,SPP1,YWHAG,ANLN,HNRNPAB,FGFR2,TXNRD1,LMCD1,TMEM55A,ADAM12,TMEM176A,RTN4,TMX2,INSR,ACTG1,ARL2,SCD,ERAP2,NME1,ADAM17,LEP,SLC1A4,CHCHD10,FGF2,PKM,FKBP1A,HIF1A,PDGFC,ALDH2,TMEFF1,JUN,ANXA1,TOP2A,SENP3,KIT,ASPH,MCRS1,NFE2L2,ATP13A2,AKR1C1/AKR1C2,TUBB4B,NQO1,SLC39A6,MAPK9,ENG,IPO7,SOD1,CSF1R,FTL,SOX9,CBX4	81	
Cardiac Proliferation	proliferation	proliferation of heart cells	3.75E-02	 	-0.162	 	-0.550	ADAM17,LEP,FGF2,ADIPOQ,FGF1,CXCL10,HMOX1,ITGB2,PLCE1,EDN1,KIT,GNL3,STAT1,NACA	14	
Kidney Failure	failure	failure of kidney	3.88E-02	 	-1.616	bias	-0.084	APOB,SLC7A11,RRM2B,ADIPOQ,FKBP1A,GSS,APRT,CD28,HMOX1,LGMN,GBA,EDN1,THBS1,TOP2A,ADORA1,FCGR3A/FCGR3B,SPP1,SGCG,FCGR2A,GLIS2,NPR3,FCER1G,P2RY12,ARHGDIA,CYR61,TNS1,ADRA1A,GSTP1,CD151	29	
Cardiac Damage	cardiovascular toxicity	cardiovascular toxicity	3.90E-02	 	 	 	 	ABCC1,CYBB,CBR1	3	
Renal Inflammation, Renal Nephritis	nephritis	Nephritis	4.00E-02	Decreased	-2.269	bias	-0.363	TRAF3,LEP,GADD45B,DDIT3,AGER,CD2,FKBP1A,C1QA,HLA-DQB1,HIF1A,ASNS,APRT,FAS,PTPRC,CD28,SLC19A3,HMOX1,JUN,TOP2A,CFH,MAPKAPK2,NFE2L2,FCGR3A/FCGR3B,TOP3B,TP53,CCR1,VCAM1,SPP1,FCGR2A,DGAT2,IRF5,PKN1,CXCL16,EFS,GLIS2,IL1RN,PSMB2,PSMD2,ARHGDIA,TNS1,CD151	41	
Pulmonary Hypertension	pulmonary hypertensive arterial disease	pulmonary hypertensive arterial disease	4.15E-02	 	 	 	 	APOE,FHL1,EDN1,ITSN1,KIT,P2RY12,RET,CSF1R	8	
Renal Damage	injury	injury of kidney	4.45E-02	 	-0.000	 	-0.479	CCR1,LEP,THBS1,FGF2,FCGR2A,UNC5B,RAC1,ARHGDIA,ANXA7,CFH,ADORA1,C3AR1	12	
Pulmonary Hypertension	pulmonary hypertension	Pulmonary Hypertension	4.79E-02	 	 	 	 	APOE,MIF,FHL1,EDN1,ITSN1,NPR3,IL1RN,KIT,P2RY12,RET,SLC9A1,CSF1R	12	
Congenital Heart Anomaly	persistent truncus arteriosus	persistent truncus arteriosus	4.85E-02	 	-0.946	bias	 	JUN,FLNA,PCSK6,DVL1,DVL3,PLXND1	6	
Cardiac Inflammation	pericarditis	pericarditis	4.90E-02	 	 	 	 	TUBB4B,TUBG1,TUBB2A,TUBA1C	4	
Liver Inflammation/Hepatitis, Liver Steatosis	steatohepatitis	steatohepatitis	5.05E-02	 	0.447	bias	 	LEP,APOB,ADIPOQ,CD14,SOD1,ADORA1,NFE2L1	7	
Renal Inflammation, Renal Nephritis	experimental crescentic glomerulonephritis	experimental crescentic glomerulonephritis	5.34E-02	 	 	 	 	SPP1,IL1RN	2	
Renal Inflammation, Renal Nephritis	immune complex nephritis	immune complex nephritis	5.34E-02	 	 	 	 	IL1RN,FAS	2	
Cardiac Damage, Cardiac Degeneration	injury	injury of cardiomyocytes	5.34E-02	 	 	 	 	PIM3,TXN	2	
Cardiac Stress Response	oxidative stress response	oxidative stress response of cardiac muscle	5.34E-02	 	 	 	 	TXN,INSR	2	
Renal Necrosis/Cell Death	apoptosis	apoptosis of kidney cells	5.51E-02	 	-0.426	 	-0.619	TP53,APOE,GFPT1,EDN1,DDIT3,CCNI,GLIS2,FGF2,UNC5B,SFRP1,HIF1A,ADORA1	12	
Congenital Heart Anomaly	ventricular septal defect	ventricular septal defect	5.56E-02	 	-1.112	bias	 	ADAM17,JUN,EDN1,NTRK3,FLNA,ACKR3,DVL1,PCSK6,TGFB2,FKBP1A,SLC19A1,DVL3,MEGF8,AIP	14	
Glomerular Injury	glomerulosclerosis	glomerulosclerosis	5.71E-02	Decreased	-2.917	bias	-1.481	CCR1,APOE,HMOX1,LGMN,SPP1,SGCG,AGER,GLIS2,MTSS1,ANLN,RRM2B,ADIPOQ,STAB1,ARHGDIA,TNS1,APRT,CD151	17	
Renal Inflammation, Renal Nephritis	autoimmune glomerulonephritis	autoimmune glomerulonephritis	5.92E-02	 	 	 	 	TP53,JUN,DDIT3,PSMB2,PSMD2,DGAT2,FKBP1A,CFH,ASNS	9	
Congenital Heart Anomaly	congenital heart disease	congenital heart disease	5.97E-02	Decreased	-2.099	bias	 	ADAM17,SNTA1,TXNL4A,NCSTN,FKBP1A,NAA10,PLCE1,JUN,EDN1,FLNA,TGFB2,SLC19A1,GNG5,MGAT1,FCGR3A/FCGR3B,FCGR2A,DVL1,PCSK6,ENG,PLXND1,AIP,CALM1 (includes others),NTRK3,ACKR3,P2RY12,DVL3,MEGF8	27	
Liver Hyperplasia/Hyperproliferation	liver tumor	liver tumor	6.10E-02	 	-0.269	 	0.152	PCLO,RPE,AGER,ASS1,PIK3R1,GARS,POLRMT,LRRN4CL,SPRY4,BTBD11,POR,CCND3,ATG9A,GLB1,ARHGEF26,VIT,SLC2A5,RBM38,YWHAG,ANXA2,IRF5,ALCAM,ELMO2,ACTG1,EPHX1,CD163L1,BANK1,EVA1B,FHL1,DDIT3,SLC1A5,ALPK2,AMOT,MTSS1L,UCP2,TUBB4B,RNF157,ENG,IPO7,MAGEC3,MYO5A,MTHFD1L,AFF3,DERL1,NR4A1,RPL37,SOX9,STK31,DCX,SOCS3,NACAD,YWHAH,EML4,FCER1A,AP1B1,INTS1,LHFPL2,CTSD,STC2,MTMR2,ADAMTS5,NSMAF,C12orf49,STXBP1,ASNA1,MAPK8IP2,RIMS4,FYB,TXNRD1,NAGLU,TMX2,INSR,CBX3,TNS1,ETV5,SCD,CARS,F2RL3,FAT3,NHP2,RPL7A,COL6A6,ALDH2,IGSF8,STAT1,AKR1C1/AKR1C2,TRIM55,IPO4,G6PD,SOD1,SNX27,DHX8,SAA2,TSN,MAP4K4,CPAMD8,SNTA1,ITGA8,ARPC5,RAN,GHITM,MKI67,SGPL1,TMEM268,LGMN,MKX,PXK,POU6F2,KIF21A,ZBTB16,POLR2I,UBXN6,CPNE4,BCAP29,TSR3,FARSA,PRELID1,KIAA0408,RTN4,ME2,ARHGAP35,KRTAP4-4,LRP2BP,GSTP1,FCGRT,SLC1A3,HYOU1,ST6GALNAC4,FKBP1A,COASY,GPC4,RCOR2,ENAH,CADM2,RPUSD3,CES1,JUN,MYO5C,DIP2B,TUB,TXNL1,LIMCH1,RPS24,PLXNA1,SIGLEC1,NAP1L4,NOL6,PTPRK,TRIM28,LRRC8D,HIST1H1B,SNTG2,SLC48A1,SOX6,RHBDD2,BRINP2,SBF1,TREM2,MMS19,AOX1,NCAM1,PER1,PLCB2,PFN1,ARF1,PRMT3,MYH15,UNC5B,MAP1B,FAM127B,ZNF91,TRIM31,RSPO3,CNDP2,CAMK2D,PLCE1,CFL2,DPP3,TMEM230,COMT,NMNAT2,ANXA7,GOT1,RET,C7orf50,MFSD3,HK1,SHOC2,PRKRA,TRIOBP,FAM45A,RPL12,ATP10A,GALNT13,GPAA1,PREX1,MAPT,TMEM176A,FMN2,RARRES3,TSTD1,CYP4A11,ARL2,SPIRE1,SRM,FPR3,SH3RF3,ATF5,PCDHAC2,PCDH19,MRPS30,RPS4X,THBS1,CYGB,ASAP3,ATP5I,TMEM220,SCN2A,COL5A2,HSPH1,VSIG4,MRPS16,KIFAP3,PLXND1,ANO2,TMEM2,PAG1,GBE1,NCKAP1L,PPP2R1B,HLTF,SEMA4B,DHRS7B,KLHDC8B,WHSC1,KDM6B,PCDHAC1,LRRC1,CLSTN2,PCIF1,SLC35C1,CLIP1,ODC1,NPL,PTPRC,SRPX2,KEAP1,FRAS1,ST6GALNAC2,SPTB,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,TP53,ATP5J,PLD3,MTSS1,PPP1R1B,PAQR3,TMEM201,CARMIL1,FGFR2,DSG1,HSPA8,SLC7A10,TMEM127,CTSA,SCUBE1,TMEM55A,MRNIP,ATXN7L3,ABCF3,UCK1,DUSP4,TULP3,CHD1L,SQSTM1,TMEM33,LYPLA1,ESR2,TRAPPC5,FKBP2,APOE,NME1,FBXO10,SFXN4,CHCHD10,FGF2,OSGIN1,CUBN,HS2ST1,HSPB8,ZNF827,SLC35B2,COL16A1,OGT,SHTN1,TMEFF1,SORBS1,TNXB,OSBPL11,ASPH,NFE2L2,KRT10,CCR1,S100A1,TMC2,WDR36,SRA1,GNA12,DGAT2,SLC39A6,LZTS2,TMEM25,CPEB4,ISG15,TBC1D13,FOS,MYOC,MOBP,NTRK3,FLNC,MBD3,PSAP,ARHGDIA,TTYH3,SEMA3C,ABCC3,PPIL1,HAGH,PTER,ABCB6,KCTD2,MEGF9,ABCA3,MBP,TYMP,CES2,HSPA5,BIN1,NNMT,TMEM132C,RHOG,CYP3A5,GDE1,ENTPD5,PACS2,NUPR1,HOXA7,STAB1,C17orf53,MFSD14A,HNRNPAB,CAPG,GYS2,DMXL2,KCNG1,TLN2,ADAM12,ALG3,PPA2,CDH20,PIK3AP1,MEGF8,CST6,PTGFR,ERAP2,UBXN1,SLC1A4,MSR1,MECR,DMD,PDGFC,HNRNPK,IRAK1,CSRP2BP,PREPL,TIMP1,DNAJC4,ADCK3,CIZ1,MCRS1,IARS,LONP1,ATP13A2,FAM171B,VCAM1,ZNF358,NQO1,HPS1,TRPA1,NMT2,AIFM2,ATIC,NFE2L1,SHB,GIPR,PCCA,KIF5B,PSMD2,EIF3I,TBC1D7,C5orf22,GZF1,SLC29A4,CADM3,PMVK,APOB,SH3BGRL3,HRAS,SH3GLB1,KPNA1,CHST2,BCAT1,DYNLL1,DGCR6L,PEG10,ABCC1,PIK3CG,RPS2,TXN,EYA2,TMEM9B,AASS,TSPAN33,CTPS1,ANGPTL1,NR1D1,YARS,GLUL,SFRP1,TCF7,CYR61,ITGA7,C3AR1,LCP2,ALDH4A1,ADAM17,MSC,UBQLN1,CTNNA1,PFKL,TTC1,PIP,UCHL1,DCLK2,TOP2A,PSMD14,SARS,AMFR,PI4KA,PLOD3,LETM1,ADRM1,EPB41L4B,ATXN2L,AREL1,FTL,ADCY1,P2RY12,CBX4,RUFY3,ACTR1A,EFR3A,MVD,MMRN1,SDC4,DYNLT1,UBA2,SLC7A5,CLCN3,TENM2,EIF2AK1,PTX3,SPP1,SGCG,ANLN,RAB10,UQCR11,MARS,PKN1,EPRS,LMCD1,SEL1L,EFS,GNL3,UBE2J2,LEP,EPB41L3,CD2,CUTA,PKM,SLC7A1,FAM47E,HIF1A,GANAB,RAMP2,SEPHS2,HMOX1,RNF167,PCK2,FLNA,KCNMA1,ANXA1,VCP,TGFB2,SENP3,POLN,KIT,ARHGEF2,SLC40A1,NR2F6,BHMT2,ALPL,STK40,HMGCS1,ACTN1,RAB8B,NLRC4,PRNP,NACA,FRMD1,ADCY2,MRC2,DCTPP1,AP3D1,COPS7A,NXPH4,MAPK9,SLC5A3,CSF1R,KCNQ4,TRPM6,WARS,PANK3,MAT2A,RTN3,CARM1	540	
Cardiac Proliferation	proliferation	proliferation of cardiac fibroblasts	6.36E-02	 	 	 	 	FGF2,ADIPOQ,STAT1	3	
Cardiac Proliferation	proliferation	proliferation of ventricular myocytes	6.36E-02	 	 	 	 	PLCE1,LEP,EDN1	3	
Liver Cirrhosis	cirrhosis	cirrhosis of liver	6.93E-02	 	 	 	 	TP53,APOB,SPP1,LEP,SLC4A2,TBC1D9,NQO1,HLA-DQB1,HNRNPK,FGF1,SREBF2,CCL28,ABCC1,HLA-DRA,TGFB2,NR4A1,GCLM,ABCC3,ALPL,NFE2L2,ADRA1A	21	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiac muscle	7.14E-02	 	0.289	 	-0.223	CRYAB,LEP,PFKFB1,FGF2,GDF15,HSPB8,ADIPOQ,RAC1,PPIA,DMD,H2AFZ,SLC9A1,LMCD1,MTPN,CAMK2D,PLCE1,EDN1,TIMP1,PRMT5,ADORA1	20	
Liver Hyperplasia/Hyperproliferation	cancer	liver cancer	7.31E-02	 	-0.293	 	0.052	PCLO,RPE,AGER,ASS1,PIK3R1,GARS,POLRMT,LRRN4CL,SPRY4,BTBD11,POR,CCND3,ATG9A,GLB1,ARHGEF26,VIT,SLC2A5,YWHAG,ANXA2,IRF5,ALCAM,ELMO2,ACTG1,EPHX1,CD163L1,BANK1,EVA1B,FHL1,DDIT3,SLC1A5,ALPK2,AMOT,MTSS1L,UCP2,TUBB4B,RNF157,ENG,IPO7,MAGEC3,MYO5A,MTHFD1L,AFF3,DERL1,NR4A1,RPL37,SOX9,STK31,DCX,SOCS3,NACAD,YWHAH,EML4,FCER1A,AP1B1,INTS1,LHFPL2,CTSD,STC2,MTMR2,ADAMTS5,NSMAF,C12orf49,STXBP1,ASNA1,MAPK8IP2,RIMS4,FYB,TXNRD1,NAGLU,TMX2,INSR,CBX3,TNS1,ETV5,SCD,CARS,F2RL3,FAT3,NHP2,RPL7A,COL6A6,ALDH2,IGSF8,STAT1,AKR1C1/AKR1C2,TRIM55,IPO4,G6PD,SOD1,SNX27,DHX8,SAA2,TSN,MAP4K4,CPAMD8,SNTA1,ITGA8,ARPC5,RAN,GHITM,MKI67,SGPL1,TMEM268,LGMN,MKX,PXK,POU6F2,KIF21A,ZBTB16,POLR2I,UBXN6,CPNE4,BCAP29,TSR3,FARSA,PRELID1,KIAA0408,RTN4,ME2,ARHGAP35,KRTAP4-4,LRP2BP,GSTP1,FCGRT,SLC1A3,HYOU1,ST6GALNAC4,FKBP1A,COASY,GPC4,RCOR2,ENAH,CADM2,RPUSD3,CES1,JUN,MYO5C,DIP2B,TUB,TXNL1,LIMCH1,RPS24,PLXNA1,SIGLEC1,NAP1L4,NOL6,PTPRK,TRIM28,LRRC8D,HIST1H1B,SNTG2,SLC48A1,SOX6,RHBDD2,BRINP2,SBF1,TREM2,MMS19,AOX1,NCAM1,PER1,PLCB2,PFN1,ARF1,PRMT3,MYH15,UNC5B,MAP1B,FAM127B,ZNF91,TRIM31,RSPO3,CNDP2,CAMK2D,PLCE1,CFL2,DPP3,TMEM230,COMT,NMNAT2,ANXA7,GOT1,RET,C7orf50,MFSD3,HK1,SHOC2,PRKRA,TRIOBP,FAM45A,RPL12,ATP10A,GALNT13,GPAA1,PREX1,MAPT,TMEM176A,FMN2,RARRES3,TSTD1,CYP4A11,ARL2,SPIRE1,SRM,FPR3,SH3RF3,ATF5,PCDHAC2,PCDH19,MRPS30,RPS4X,THBS1,CYGB,ASAP3,ATP5I,TMEM220,SCN2A,COL5A2,HSPH1,VSIG4,MRPS16,KIFAP3,PLXND1,ANO2,TMEM2,PAG1,GBE1,NCKAP1L,PPP2R1B,HLTF,SEMA4B,DHRS7B,KLHDC8B,WHSC1,KDM6B,PCDHAC1,LRRC1,CLSTN2,PCIF1,SLC35C1,CLIP1,NPL,PTPRC,SRPX2,KEAP1,FRAS1,ST6GALNAC2,SPTB,STAM,MYBBP1A,MGAT1,GREB1L,MRPL24,TP53,ATP5J,PLD3,MTSS1,PPP1R1B,PAQR3,TMEM201,CARMIL1,FGFR2,DSG1,HSPA8,SLC7A10,TMEM127,CTSA,SCUBE1,TMEM55A,MRNIP,ATXN7L3,ABCF3,UCK1,DUSP4,TULP3,CHD1L,SQSTM1,TMEM33,LYPLA1,ESR2,TRAPPC5,FKBP2,APOE,NME1,FBXO10,SFXN4,CHCHD10,FGF2,OSGIN1,CUBN,HS2ST1,HSPB8,ZNF827,SLC35B2,COL16A1,OGT,SHTN1,TMEFF1,SORBS1,TNXB,OSBPL11,ASPH,NFE2L2,KRT10,CCR1,S100A1,TMC2,WDR36,SRA1,GNA12,DGAT2,SLC39A6,TMEM25,CPEB4,ISG15,TBC1D13,FOS,MYOC,MOBP,NTRK3,FLNC,MBD3,PSAP,ARHGDIA,TTYH3,SEMA3C,ABCC3,PPIL1,HAGH,PTER,ABCB6,KCTD2,MEGF9,ABCA3,MBP,TYMP,CES2,HSPA5,BIN1,NNMT,TMEM132C,RHOG,CYP3A5,GDE1,ENTPD5,PACS2,NUPR1,HOXA7,STAB1,C17orf53,MFSD14A,HNRNPAB,CAPG,GYS2,DMXL2,KCNG1,TLN2,ADAM12,ALG3,PPA2,CDH20,PIK3AP1,MEGF8,CST6,PTGFR,ERAP2,UBXN1,SLC1A4,MSR1,MECR,DMD,PDGFC,HNRNPK,IRAK1,CSRP2BP,PREPL,TIMP1,DNAJC4,ADCK3,CIZ1,MCRS1,IARS,LONP1,ATP13A2,FAM171B,VCAM1,ZNF358,NQO1,HPS1,TRPA1,NMT2,AIFM2,ATIC,NFE2L1,SHB,GIPR,PCCA,KIF5B,PSMD2,EIF3I,TBC1D7,C5orf22,GZF1,SLC29A4,CADM3,PMVK,APOB,SH3BGRL3,HRAS,SH3GLB1,KPNA1,CHST2,BCAT1,DYNLL1,DGCR6L,ABCC1,PIK3CG,RPS2,TXN,EYA2,TMEM9B,AASS,TSPAN33,CTPS1,ANGPTL1,NR1D1,YARS,SFRP1,TCF7,CYR61,ITGA7,C3AR1,LCP2,ALDH4A1,ADAM17,MSC,UBQLN1,CTNNA1,PFKL,TTC1,PIP,UCHL1,DCLK2,TOP2A,PSMD14,SARS,AMFR,PI4KA,PLOD3,LETM1,ADRM1,EPB41L4B,ATXN2L,AREL1,FTL,ADCY1,P2RY12,CBX4,RUFY3,ACTR1A,EFR3A,MVD,SDC4,MMRN1,DYNLT1,UBA2,SLC7A5,CLCN3,TENM2,EIF2AK1,PTX3,SPP1,SGCG,ANLN,RAB10,UQCR11,MARS,PKN1,EPRS,LMCD1,SEL1L,EFS,GNL3,UBE2J2,LEP,EPB41L3,CD2,CUTA,PKM,SLC7A1,FAM47E,HIF1A,GANAB,RAMP2,SEPHS2,HMOX1,RNF167,PCK2,FLNA,KCNMA1,ANXA1,VCP,TGFB2,SENP3,POLN,KIT,ARHGEF2,SLC40A1,NR2F6,BHMT2,ALPL,STK40,HMGCS1,RAB8B,NLRC4,ACTN1,PRNP,NACA,FRMD1,ADCY2,MRC2,DCTPP1,AP3D1,COPS7A,NXPH4,MAPK9,SLC5A3,CSF1R,KCNQ4,TRPM6,WARS,PANK3,MAT2A,RTN3,CARM1	535	
Liver Proliferation	proliferation	proliferation of hepatocytes	7.35E-02	 	0.961	 	0.277	TP53,SOCS3,HRAS,MAPK9,FGFR2,ODC1,FAS,TNFRSF12A,FOS,JUN,CCND3,TIMP1,THBS1,IL1RN,ENTPD5,CXCL14,SLC7A5,INSR,NFE2L2	19	
Cardiac Enlargement	enlargement	enlargement of heart ventricle	7.59E-02	 	 	 	 	ADORA1,P2RX7	2	
Increased Levels of ALT	release	increased release of ALT	7.59E-02	 	 	 	 	SPP1,MAPK9	2	
Cardiac Stenosis	stenosis	stenosis of pulmonary valve	7.59E-02	 	 	 	 	NTRK3,ACKR3	2	
Cardiac Arteriopathy	vasospasm	vasospasm of coronary artery	7.59E-02	 	 	 	 	SGCG,SOD1	2	
Cardiac Hypertrophy	hypertrophy	hypertrophy of cardiomyocytes	7.77E-02	 	-0.546	 	-0.916	CRYAB,LEP,FGF2,GDF15,ADIPOQ,HSPB8,PPIA,DMD,H2AFZ,SLC9A1,LMCD1,CAMK2D,PLCE1,EDN1,TIMP1,PRMT5,ADORA1	17	
Liver Inflammation/Hepatitis	experimental hepatitis	experimental hepatitis	7.80E-02	 	 	 	 	SCD,LEP,FAS	3	
Cardiac Arrythmia	Brugada syndrome type 10	Brugada syndrome type 10	7.92E-02	 	 	 	 	KCND3	1	
Congenital Heart Anomaly	Burn-McKeown syndrome	Burn-McKeown syndrome	7.92E-02	 	 	 	 	TXNL4A	1	
Congenital Heart Anomaly	Ogden syndrome	Ogden syndrome	7.92E-02	 	 	 	 	NAA10	1	
Hepatocellular Peroxisome Proliferation	activation	activation of PPARA in liver cells	7.92E-02	 	 	 	 	PLIN2	1	
Cardiac Infarction	acute periprocedural myocardial infarction	acute periprocedural myocardial infarction	7.92E-02	 	 	 	 	P2RY12	1	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	advanced stage nonalcoholic steatohepatitis	7.92E-02	 	 	 	 	LEP	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatoblasts	7.92E-02	 	 	 	 	JUN	1	
Liver Hyperplasia/Hyperproliferation	cancer	cancer of hepatocytes	7.92E-02	 	 	 	 	TIMP1	1	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 4	catecholaminergic polymorphic ventricular tachycardia type 4	7.92E-02	 	 	 	 	CALM1 (includes others)	1	
Liver Inflammation/Hepatitis	hepatitis	chronic phase hepatitis	7.92E-02	 	 	 	 	HLA-A	1	
Cardiac Hypertrophy	concentric hypertrophy of left ventricle	concentric hypertrophy of left ventricle	7.92E-02	 	 	 	 	PLIN5	1	
Renal Degeneration	degeneration	degeneration of renal tubular epithelial cells	7.92E-02	 	 	 	 	ARHGDIA	1	
Renal Degradation	degradation	degradation of renal tubule	7.92E-02	 	 	 	 	PSAP	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	regression	delay in initiation of regression of hepatocellular carcinoma	7.92E-02	 	 	 	 	TP53	1	
Cardiac Dysfunction	dysfunction	dysfunction of myocardium	7.92E-02	 	 	 	 	LEP	1	
Cardiac Dysplasia	dysplasia	dysplasia of right ventricle	7.92E-02	 	 	 	 	RPSA	1	
Liver Inflammation/Hepatitis, Liver Steatosis	experimental nonalcoholic steatohepatitis	experimental nonalcoholic steatohepatitis	7.92E-02	 	 	 	 	ADIPOQ	1	
Cardiac Fibrosis	fibrosis	fibrosis of right ventricle	7.92E-02	 	 	 	 	CTNNA1	1	
Glomerular Injury	focal segmental glomerulosclerosis type 8	focal segmental glomerulosclerosis type 8	7.92E-02	 	 	 	 	ANLN	1	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of proximal tubule cells	7.92E-02	 	 	 	 	LGMN	1	
Increased Levels of Albumin	export	increased export of albumin	7.92E-02	 	 	 	 	RAN	1	
Increased Levels of Albumin	secretion	increased secretion of albumin	7.92E-02	 	 	 	 	APP	1	
Liver Cirrhosis	indian childhood cirrhosis	indian childhood cirrhosis	7.92E-02	 	 	 	 	UTP4	1	
Renal Inflammation, Renal Nephritis	inflammation	inflammation of renal tubule	7.92E-02	 	 	 	 	APRT	1	
Cardiac Inflammation	inflammatory dilated cardiomyopathy	inflammatory dilated cardiomyopathy	7.92E-02	 	 	 	 	IL17RA	1	
Liver Damage	lesioning	lesioning of liver	7.92E-02	 	 	 	 	TP53	1	
Glomerular Injury	lipoprotein glomerulopathy	lipoprotein glomerulopathy	7.92E-02	 	 	 	 	APOE	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 12	long QT syndrome type 12	7.92E-02	 	 	 	 	SNTA1	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 14	long QT syndrome type 14	7.92E-02	 	 	 	 	CALM1 (includes others)	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome type 15	long QT syndrome type 15	7.92E-02	 	 	 	 	CALM1 (includes others)	1	
Liver Inflammation/Hepatitis	necroinflammatory liver disease	necroinflammatory liver disease	7.92E-02	 	 	 	 	ADIPOQ	1	
Nephrosis	nephronophthisis 7	nephronophthisis 7	7.92E-02	 	 	 	 	GLIS2	1	
Renal Inflammation, Renal Nephritis	nephropathy with pretibal epidermolysis bullosa and deafness	nephropathy with pretibal epidermolysis bullosa and deafness	7.92E-02	 	 	 	 	CD151	1	
Nephrosis	nephrotic syndrome type 3	nephrotic syndrome type 3	7.92E-02	 	 	 	 	PLCE1	1	
Nephrosis	nephrotic syndrome type 8	nephrotic syndrome type 8	7.92E-02	 	 	 	 	ARHGDIA	1	
Liver Hyperplasia/Hyperproliferation	nodular hyperplasia	nodular hyperplasia of liver	7.92E-02	 	 	 	 	SOD1	1	
Cardiac Necrosis/Cell Death	apoptosis	onset of apoptosis of cardiomyocytes	7.92E-02	 	 	 	 	LEP	1	
Cardiac Hypertrophy	hypertrophy	onset of hypertrophy of cardiomyocytes	7.92E-02	 	 	 	 	LEP	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	recurrent hepatocellular carcinoma	recurrent hepatocellular carcinoma	7.92E-02	 	 	 	 	HNRNPAB	1	
Liver Hyperplasia/Hyperproliferation	liver cancer	recurrent liver cancer	7.92E-02	 	 	 	 	TP53	1	
Cardiac Damage	rupture	rupture of ventricular septum	7.92E-02	 	 	 	 	CTNNA1	1	
Glomerular Injury, Kidney Failure, Renal Fibrosis	tubulo-interstitial fibrosis	tubulo-interstitial fibrosis of renal cortex	7.92E-02	 	 	 	 	GLIS2	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of hepatic stellate cells	7.95E-02	 	-1.154	 	-1.424	TIMP1,ADIPOQ,ITGAV,FAS	4	
Liver Hyperbilirubinemia	hyperbilirubinemia	hyperbilirubinemia	7.95E-02	 	 	 	 	FCGR2A,ABCC3,GSTP1,FCGR3A/FCGR3B	4	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction	8.44E-02	 	 	 	 	SCD,LEP,NPR3,CYBB,HRAS	5	
Cardiac Dysfunction	systolic dysfunction	systolic dysfunction	8.44E-02	Increased	2.000	 	2.000	SCD,LEP,ANXA5,CYBB,FKBP1A	5	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	advanced stage hepatocellular carcinoma	9.14E-02	 	 	 	 	POR,TOP2A,KIT,RET	4	
Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of kidney cells	9.14E-02	Decreased	-2.000	bias	 	LGMN,CFH,PKN1,CD151	4	
Liver Damage	damage	damage of hepatocytes	9.36E-02	 	 	 	 	MIF,IL1RN,EGR1	3	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney component	9.36E-02	 	 	 	 	GLIS2,STAB1,APRT	3	
Kidney Failure, Liver Failure	hepatorenal syndrome	hepatorenal syndrome	9.36E-02	 	 	 	 	EDN1,TOP2A,ADRA1A	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	progressive liver metastasis	9.36E-02	 	 	 	 	KIT,FGFR2,RET	3	
Liver Hyperplasia/Hyperproliferation	liver metastasis	symptomatic stage iodine-refractory liver metastasis	9.36E-02	 	 	 	 	KIT,FGFR2,RET	3	
Cardiac Stenosis	stenosis	stenosis of semilunar valve	9.77E-02	 	0.132	bias	 	VCAM1,PLCE1,SPP1,APOB,NTRK3,TIMP1,ACKR3	7	
Cardiac Dysfunction	dysfunction	dysfunction of heart	9.98E-02	 	1.177	 	1.361	PTX3,SCD,APOE,ALDH2,CRYAB,LEP,TIMP1,PIK3CG,CYBB,DUSP4	10	
Liver Cirrhosis	primary biliary cirrhosis	early stage primary biliary cirrhosis	1.01E-01	 	 	 	 	APOB,SREBF2	2	
Cardiac Enlargement	enlargement	enlargement of cardiomyocytes	1.01E-01	 	 	 	 	EDN1,KLF4	2	
Cardiac Fibrosis	interstitial fibrosis	interstitial fibrosis of left ventricle	1.01E-01	 	 	 	 	PTX3,CYBB	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	quantity	quantity of hepatocellular carcinoma	1.01E-01	 	 	 	 	JUN,LEP	2	
Liver Necrosis/Cell Death	apoptosis	apoptosis of liver cell lines	1.05E-01	 	0.826	 	0.412	TP53,GADD45B,TIMP1,DUSP4,FAS	5	
Heart Failure	cardiac decompensation	cardiac decompensation	1.10E-01	 	 	 	 	NPR3,DUSP6,ADRA1A	3	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	crescentic glomerulonephritis	1.10E-01	 	 	 	 	VCAM1,SPP1,IL1RN	3	
Renal Damage, Renal Tubule Injury	damage	damage of tubulointerstitium	1.10E-01	 	 	 	 	CCR1,APOE,EDN1	3	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of mesangial cells	1.10E-01	 	 	 	 	PARK7,EDN1,NUPR1	3	
Increased Levels of AST	localization	increased localization of AST	1.10E-01	 	 	 	 	APOE,SAA1,FAS	3	
Renal Hydronephrosis	hydronephrosis	hydronephrosis	1.11E-01	Decreased	-2.195	bias	 	TGFBR1,LGMN,LEP,TGFB2,ALCAM,PSAP,LZTS2,VAMP8,CXCL9,APRT,ADRA1A	11	
Liver Damage	hepatotoxicity	hepatotoxicity	1.16E-01	 	 	 	 	SLC7A11,NFE2L2,GSS,FAS,AIP	5	
Cardiac Arrythmia	long-QT syndrome	long-QT syndrome	1.16E-01	 	 	 	 	SLC2A5,CALM1 (includes others),PIK3CG,SNTA1,PI4KA	5	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular myocytes	1.17E-01	 	-1.958	 	-2.202	PLCE1,LEP,EDN1,PRMT5	4	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal glomerulus	1.23E-01	 	-0.055	 	-0.161	TP53,APOE,GFPT1,EDN1,CCNI,FGF2,C1QA	7	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of kidney	1.27E-01	Decreased	-2.546	bias	-1.264	LGMN,SPP1,SGCG,AGER,GLIS2,MTSS1,ADIPOQ,STAB1,APRT,CD151	10	
Liver Adhesion	adhesion	adhesion of liver cells	1.28E-01	 	 	 	 	VCAM1,ADAM12	2	
Liver Fibrosis	chemotaxis	chemotaxis of hepatic stellate cells	1.28E-01	 	 	 	 	CXCL10,FGF2	2	
Cardiac Fibrosis	perivascular fibrosis	perivascular fibrosis	1.28E-01	 	 	 	 	HMOX1,PLA2G2A	2	
Renal Inflammation, Renal Nephritis	pyelonephritis	pyelonephritis	1.28E-01	 	 	 	 	TOP2A,APRT	2	
Cardiac Infarction	ST-elevation myocardial infarction	ST-elevation myocardial infarction	1.28E-01	 	 	 	 	PTX3,ITGAV,P2RY12	3	
Liver Inflammation/Hepatitis, Liver Steatosis	nonalcoholic steatohepatitis	nonalcoholic steatohepatitis	1.31E-01	 	 	 	 	LEP,APOB,ADIPOQ,ADORA1	4	
Renal Proliferation	proliferation	proliferation of mesangial cells	1.32E-01	 	-0.765	bias	-1.415	CXCL10,APOE,EDN1,FCER1G,CXCL9,AKR1B1	6	
Renal Inflammation, Renal Nephritis	IgA nephropathy	IgA nephropathy	1.40E-01	 	 	 	 	TP53,JUN,PSMB2,PSMD2,DGAT2	5	
Cardiac Dilation	dilation	dilation of heart chamber	1.42E-01	 	-1.134	 	-0.771	GAB2,CAMK2D,CAPNS1,PLCE1,SPP1,TIMP1,NUPR1	7	
Renal Dysplasia	dysplasia	dysplasia of kidney	1.47E-01	 	 	 	 	FRAS1,ITGA8,RET	3	
Increased Levels of Potassium	excretion	increased excretion of K+	1.47E-01	 	 	 	 	LEP,AKR1B1,CYP4A11	3	
Cardiac Arrythmia	Brugada syndrome type 9	Brugada syndrome type 9	1.52E-01	 	 	 	 	KCND3	1	
Liver Hyperbilirubinemia	Dubin-Johnson syndrome	Dubin-Johnson syndrome	1.52E-01	 	 	 	 	ABCC3	1	
Renal Inflammation, Renal Nephritis	acute proliferative glomerulonephritis	acute proliferative glomerulonephritis	1.52E-01	 	 	 	 	MAPKAPK2	1	
Renal Inflammation, Renal Nephritis	acute pyelonephritis	acute pyelonephritis	1.52E-01	 	 	 	 	TOP2A	1	
Liver Adhesion	adhesion	adhesion of hepatic stellate cells	1.52E-01	 	 	 	 	ADAM12	1	
Liver Necrosis/Cell Death	apoptosis	apoptosis of sinusoidal endothelial cells	1.52E-01	 	 	 	 	FAS	1	
Cardiac Arteriopathy	atherosclerosis	atherosclerosis of coronary artery	1.52E-01	 	 	 	 	APOE	1	
Liver Hyperplasia/Hyperproliferation	beta-catenin activating mutation positive hepatocellular adenoma	beta-catenin activating mutation positive hepatocellular adenoma	1.52E-01	 	 	 	 	GLUL	1	
Liver Congestion	congestion	congestion of liver	1.52E-01	 	 	 	 	ENG	1	
Liver Necrosis/Cell Death	cell death	delay in cell death of hepatocytes	1.52E-01	 	 	 	 	FAS	1	
Congenital Heart Anomaly	double inlet heart left ventricle	double inlet heart left ventricle	1.52E-01	 	 	 	 	TGFB2	1	
Liver Cholestasis	ethynylestradiol hepatocellular cholestasis	ethynylestradiol hepatocellular cholestasis	1.52E-01	 	 	 	 	GJB2	1	
Liver Proliferation	expansion	expansion of oval cells	1.52E-01	 	 	 	 	TNFRSF12A	1	
Liver Steatosis	experimental nonalcoholic fatty liver disease	experimental nonalcoholic fatty liver disease	1.52E-01	 	 	 	 	ADIPOQ	1	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of tubulointerstitium	1.52E-01	 	 	 	 	GLIS2	1	
Liver Necrosis/Cell Death	focal necrosis	focal necrosis of liver cells	1.52E-01	 	 	 	 	APOE	1	
Glomerular Injury	glomerular cyst	glomerular cyst	1.52E-01	 	 	 	 	LGMN	1	
Cardiac Hypertrophy	hypertrophy	hypertrophy of ventricular septum	1.52E-01	 	 	 	 	MYL9	1	
Increased Levels of Potassium	efflux	increased efflux of K+	1.52E-01	 	 	 	 	P2RX7	1	
Increased Levels of Albumin	flux	increased flux of albumin	1.52E-01	 	 	 	 	THBS1	1	
Liver Failure	infantile liver failure syndrome type 2	infantile liver failure syndrome type 2	1.52E-01	 	 	 	 	MARS	1	
Cardiac Damage	injury	injury of heart tissue	1.52E-01	 	 	 	 	PIK3CG	1	
Renal Damage, Renal Tubule Injury	injury	injury of tubulointerstitium	1.52E-01	 	 	 	 	CCR1	1	
Renal Damage	lesioning	lesioning of kidney	1.52E-01	 	 	 	 	TP53	1	
Glomerular Injury	lipidosis	lipidosis of renal glomerulus	1.52E-01	 	 	 	 	APOE	1	
Liver Inflammation/Hepatitis, Liver Necrosis/Cell Death	necrotizing inflammation	necrotizing inflammation of liver	1.52E-01	 	 	 	 	APOE	1	
Liver Hyperplasia/Hyperproliferation	development	onset of development of liver tumor	1.52E-01	 	 	 	 	TP53	1	
Heart Failure	heart failure	onset of heart failure	1.52E-01	 	 	 	 	CRYAB	1	
Cardiac Stress Response	oxidative stress response	oxidative stress response of cardiomyocytes	1.52E-01	 	 	 	 	INSR	1	
Kidney Failure	progressive myoclonic epilepsy type 4 with renal failure	progressive myoclonic epilepsy type 4 with renal failure	1.52E-01	 	 	 	 	GBA	1	
Cardiac Proliferation	proliferation	proliferation of adventitial fibroblasts	1.52E-01	 	 	 	 	ADIPOQ	1	
Cardiac Proliferation	proliferation	proliferation of cardiac stem cells	1.52E-01	 	 	 	 	GNL3	1	
Cardiac Pulmonary Embolism	pulmonary embolism	pulmonary embolism of lung	1.52E-01	 	 	 	 	F2RL3	1	
Cardiac Regeneration	regeneration	regeneration of cardiomyocytes	1.52E-01	 	 	 	 	MTPN	1	
Cardiac Damage	reperfusion injury	reperfusion injury of myocardium	1.52E-01	 	 	 	 	ADIPOQ	1	
Cardiac Arteriopathy	stable coronary artery disease	stable coronary artery disease	1.52E-01	 	 	 	 	P2RY12	1	
Cardiac Arteriopathy	susceptibility to severe coronary artery disease	susceptibility to severe coronary artery disease	1.52E-01	 	 	 	 	APOE	1	
Renal Hypoplasia	unilateral renal agenesis	unilateral renal agenesis	1.52E-01	 	 	 	 	FRAS1	1	
Cardiac Arrythmia	variation QT syndrome	variation QT syndrome	1.52E-01	 	 	 	 	NHLH1	1	
Congenital Heart Anomaly	conotruncal heart malformations	conotruncal heart malformations	1.54E-01	 	-1.026	bias	 	JUN,EDN1,FLNA,PCSK6,DVL1,TGFB2,DVL3,PLXND1,AIP	9	
Liver Failure	acute liver failure	acute liver failure	1.56E-01	 	 	 	 	SLC7A11,GSS	2	
Increased Levels of Potassium	quantity	increased quantity of K+	1.56E-01	 	 	 	 	STK39,SCNN1B	2	
Liver Cholestasis	secretion	secretion of bile acid	1.56E-01	 	 	 	 	HMOX1,CES1	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	size	size of hepatocellular carcinoma	1.56E-01	 	 	 	 	JUN,LEP	2	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of renal glomerulus	1.56E-01	 	 	 	 	APOE,C1QA	2	
Renal Necrosis/Cell Death	cell death	cell death of renal tubule	1.59E-01	Decreased	-2.771	 	-2.177	HMOX1,SPP1,GLIS2,THBS1,UNC5B,HIF1A,ADORA1,APRT	8	
Cardiac Arrythmia	cardiac fibrillation	cardiac fibrillation	1.61E-01	 	 	 	 	VCAM1,TUBB4B,TUBG1,SNTA1,TUBB2A,DGAT2,KCNMA1,TIMP1,P2RY12,ANXA7,TUBA1C,NHLH1,PPP1CA,P2RX7,ADRA1A	15	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of podocytes	1.62E-01	 	0.339	 	-0.039	TP53,EDN1,CCNI,FGF2	4	
Cardiac Damage	damage	damage of cardiac muscle	1.62E-01	 	-0.750	bias	-0.054	PIM3,GDF15,ADIPOQ,TXN	4	
Liver Hyperplasia/Hyperproliferation	development	development of liver tumor	1.62E-01	 	 	 	 	TP53,JUN,LZTS2,PDGFC	4	
Cardiac Fibrosis	interstitial fibrosis	interstitial fibrosis of heart	1.62E-01	 	 	 	 	PTX3,CAPNS1,CYBB,HRAS	4	
Liver Hyperplasia/Hyperproliferation	proliferation	proliferation of liver cancer cells	1.62E-01	 	1.091	 	0.642	SOCS3,LEP,PEG10,ODC1	4	
Liver Damage, Liver Inflammation/Hepatitis	hepatitis C	hepatitis C	1.63E-01	 	 	 	 	PTPRC,POR,LEP,SPP1,GAA,ADIPOQ,LGALS9,FKBP1A,INSR	9	
Renal Inflammation, Renal Nephritis	glomerulonephritis	glomerulonephritis	1.65E-01	 	-1.864	bias	-0.566	GADD45B,CD2,AGER,DDIT3,FKBP1A,C1QA,ASNS,FAS,PTPRC,CD28,HMOX1,JUN,CFH,MAPKAPK2,NFE2L2,FCGR3A/FCGR3B,TOP3B,TP53,CCR1,VCAM1,SPP1,FCGR2A,DGAT2,IRF5,PKN1,CXCL16,GLIS2,IL1RN,PSMB2,PSMD2	30	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of glomerular cells	1.65E-01	 	0.294	 	-0.037	TP53,APOE,GFPT1,EDN1,CCNI,FGF2	6	
Renal Hypertrophy	hypertrophy	hypertrophy of kidney	1.65E-01	 	0.548	 	0.995	PARK7,EDN1,AGER,ADIPOQ,NUPR1,STAB1	6	
Cardiac Stenosis	stenosis	stenosis of aortic valve	1.65E-01	 	 	 	 	VCAM1,PLCE1,SPP1,APOB,TIMP1,ACKR3	6	
Renal Hypoplasia	agenesis	agenesis of kidney	1.67E-01	 	 	 	 	FRAS1,ITGA8,RET	3	
Liver Necrosis/Cell Death	focal necrosis	focal necrosis of liver	1.67E-01	 	 	 	 	APOE,TYROBP,STAT1	3	
Pulmonary Hypertension	primary pulmonary hypertension	primary pulmonary hypertension	1.67E-01	 	 	 	 	FHL1,EDN1,P2RY12	3	
Cardiac Inflammation	carditis	carditis	1.68E-01	 	 	 	 	ITGB2,TUBB4B,ANXA1,TUBG1,TUBB2A,ADIPOQ,TUBA1C,IL17RA	8	
Congenital Heart Anomaly	familial congenital heart disease	familial congenital heart disease	1.76E-01	 	-0.990	bias	 	PLCE1,JUN,EDN1,FLNA,TXNL4A,PCSK6,DVL1,TGFB2,DVL3,NAA10,PLXND1,AIP	12	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	tumorigenesis	tumorigenesis of hepatocellular carcinoma	1.77E-01	 	 	 	 	SOCS3,ALDH2,PIK3R1,MAPK9	4	
Nephrosis	nephrosis	nephrosis	1.81E-01	 	 	 	 	CA3,PLCE1,GLIS2,ANXA1,FKBP1A,ARHGDIA,ADORA1,ATP6V1A,GSTP1	9	
Liver Inflammation/Hepatitis	viral hepatitis	viral hepatitis	1.82E-01	 	 	 	 	POR,PTPRC,IL2RG,SPP1,LEP,FCGR2A,TIMP1,GAA,TNFRSF10B,ADIPOQ,LGALS9,FKBP1A,INSR,FCGR3A/FCGR3B	14	
Renal Necrosis/Cell Death	apoptosis	apoptosis of proximal tubule cells	1.85E-01	 	 	 	 	HIF1A,ADORA1	2	
Cardiac Output	cardiac output	cardiac output of heart	1.85E-01	 	 	 	 	HRAS,ADRA1A	2	
Hepatocellular Peroxisome Proliferation	formation	formation of peroxisomes	1.85E-01	 	 	 	 	PEX3,PEX10	2	
Liver Hyperplasia/Hyperproliferation	hepatic adenocarcinoma	hepatic adenocarcinoma	1.85E-01	 	 	 	 	TP53,THBS1	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	inoperable hepatocellular carcinoma	1.85E-01	 	 	 	 	KIT,RET	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	local hepatocellular carcinoma	1.85E-01	 	 	 	 	KIT,RET	2	
Cardiac Damage	rupture	rupture of heart	1.85E-01	 	 	 	 	GDF15,CTNNA1	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	hepatocellular carcinoma	unresectable hepatocellular carcinoma	1.85E-01	 	 	 	 	KIT,RET	2	
Liver Hematopoiesis	hematopoiesis	hematopoiesis of liver	1.87E-01	 	 	 	 	CIAPIN1,FOS,SOCS3	3	
Renal Inflammation, Renal Nephritis	interstitial nephritis	interstitial nephritis	1.87E-01	 	 	 	 	ARHGDIA,TNS1,CD151	3	
Congenital Heart Anomaly	double outlet right ventricle	double outlet right ventricle	1.89E-01	 	 	 	 	EDN1,PCSK6,DVL1,TGFB2,DVL3,AIP	6	
Cardiac Hypertrophy	ventricular hypertrophy	ventricular hypertrophy	1.89E-01	Decreased	-2.259	 	-1.530	MYL9,APOE,PLCE1,LEP,EDN1,PDGFA,GAA,PRMT5,PLIN5,FKBP1A,HIF1A,HMGA1,ESR2,ADRA1A	14	
Glomerular Injury, Renal Hypertrophy	hypertrophy	hypertrophy of renal glomerulus	1.93E-01	 	0.108	 	0.578	PARK7,EDN1,ADIPOQ,NUPR1,STAB1	5	
Renal Necrosis/Cell Death	necrosis	necrosis of renal tubule	1.95E-01	Decreased	-2.596	 	-1.982	HMOX1,SPP1,GLIS2,UNC5B,HIF1A,ADORA1,APRT	7	
Glomerular Injury, Kidney Failure, Renal Fibrosis	interstitial fibrosis	interstitial fibrosis of kidney	2.02E-01	 	-1.720	bias	-0.533	LGMN,SGCG,GLIS2,ADIPOQ,APRT,CD151	6	
Renal Atrophy	atrophy	atrophy of renal tubule	2.08E-01	 	 	 	 	LGMN,GLIS2,APRT	3	
Glomerular Injury, Renal Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of mesangial cells	2.08E-01	 	 	 	 	CFH,PKN1,CD151	3	
Cardiac Dilation	dilation	dilation of heart ventricle	2.15E-01	 	-0.816	 	-0.524	GAB2,CAMK2D,CAPNS1,PLCE1,SPP1,TIMP1	6	
Renal Atrophy	atrophy	atrophy of renal cortex	2.15E-01	 	 	 	 	LGMN,APRT	2	
Congenital Heart Anomaly	congenital heart block	congenital heart block	2.15E-01	 	 	 	 	FCGR2A,FCGR3A/FCGR3B	2	
Cardiac Damage	damage	damage of myocardium	2.15E-01	 	 	 	 	GDF15,ADIPOQ	2	
Cardiac Hypertrophy	hypertrophy	hypertrophy of myocardium	2.15E-01	 	 	 	 	MTPN,RAC1	2	
Heart Failure	failure	failure of heart	2.18E-01	 	-0.132	bias	1.339	GAB2,CRYAB,SLC7A11,KCND3,DUSP6,CA5B,ADIPOQ,FKBP1A,GSS,SLC9A1,CA3,SHTN1,CAMK2D,PARK7,TIMP1,PIK3CG,STAB1,SCNN1B,SLC12A2,KIFAP3,MTPN,CAPNS1,NPR3,PTPA,P2RY12,SOX9,PPP2R1B,ADRA1A	28	
Liver Cholestasis	accumulation	accumulation of bile acid	2.19E-01	 	 	 	 	NFE2L2	1	
Liver Steatosis	alcoholic fatty liver disease	alcoholic fatty liver disease	2.19E-01	 	 	 	 	ADIPOQ	1	
Cardiac Hemorrhaging	bleeding	bleeding of pericardium	2.19E-01	 	 	 	 	TP53	1	
Cardiac Enlargement	enlargement	enlargement of left ventricle	2.19E-01	 	 	 	 	P2RX7	1	
Congenital Heart Anomaly	hypoplasia	hypoplasia of aortic arch	2.19E-01	 	 	 	 	TGFB2	1	
Glomerular Injury, Renal Hypoplasia	hypoplasia	hypoplasia of mesangial cells	2.19E-01	 	 	 	 	ARHGDIA	1	
Renal Inflammation, Renal Nephritis	idiopathic membranous nephropathy	idiopathic membranous nephropathy	2.19E-01	 	 	 	 	FKBP1A	1	
Pulmonary Hypertension	chronic thromboembolic pulmonary hypertension	inoperable chronic thromboembolic pulmonary hypertension	2.19E-01	 	 	 	 	P2RY12	1	
Liver Hyperplasia/Hyperproliferation	liver cholangiocarcinoma	liver cholangiocarcinoma	2.19E-01	 	 	 	 	TP53	1	
Renal Inflammation, Renal Nephritis	membranoproliferative glomerulonephritis	membranoproliferative glomerulonephritis	2.19E-01	 	 	 	 	CFH	1	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	metastasis	metastasis of hepatocellular carcinoma	2.19E-01	 	 	 	 	PIK3R1	1	
Renal Enlargement	nephromegaly	nephromegaly	2.19E-01	 	 	 	 	AGER	1	
Liver Cholestasis	obstruction	obstruction of bile duct	2.19E-01	 	 	 	 	GJB2	1	
Cardiac Stress Response	oxidative stress response	oxidative stress response of myocardium	2.19E-01	 	 	 	 	TXN	1	
Glutathione Depletion In Liver, Liver Fibrosis	quantity	quantity of reactive oxygen species in liver	2.19E-01	 	 	 	 	CERS2	1	
Cardiac Damage	rupture	rupture of myocardium	2.19E-01	 	 	 	 	GDF15	1	
Liver Cholestasis	secretion	secretion of taurocholic acid	2.19E-01	 	 	 	 	HMOX1	1	
Liver Damage, Liver Inflammation/Hepatitis	susceptibility to hepatitis C virus	susceptibility to hepatitis C virus	2.19E-01	 	 	 	 	PTPRC	1	
Glomerular Injury, Kidney Failure, Renal Fibrosis	tubulo-interstitial fibrosis	tubulo-interstitial fibrosis of skeletal muscle	2.19E-01	 	 	 	 	SGCG	1	
Congenital Heart Anomaly	ventricular septal defect type 3	ventricular septal defect type 3	2.19E-01	 	 	 	 	TGFB2	1	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubule	2.28E-01	Decreased	-2.400	 	-2.005	HMOX1,GLIS2,THBS1,UNC5B,HIF1A,ADORA1	6	
Liver Hemorrhaging	bleeding	bleeding of liver	2.28E-01	 	-1.000	bias	 	IL1RN,FKBP1A,RAMP2,FAS	4	
Congenital Heart Anomaly	failure of heart looping	failure of heart looping	2.28E-01	Decreased	-2.000	bias	 	TGFB2,NCSTN,ENG,GNG5	4	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis C	chronic hepatitis C	2.42E-01	 	 	 	 	POR,LEP,SPP1,GAA,ADIPOQ,LGALS9,INSR	7	
Glomerular Injury	expansion	expansion of mesangial matrix	2.45E-01	 	 	 	 	LEP,AGER	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	metastatic hepatocellular carcinoma	metastatic hepatocellular carcinoma	2.45E-01	 	 	 	 	KIT,RET	2	
Biliary Hyperplasia	proliferation	proliferation of cholangiocytes	2.45E-01	 	 	 	 	FGF2,TGFB2	2	
Cardiac Damage	reperfusion injury	reperfusion injury of heart	2.45E-01	 	 	 	 	ADIPOQ,MAPK9	2	
Cardiac Necrosis/Cell Death	cell viability	cell viability of cardiomyocytes	2.46E-01	 	 	 	 	C1QTNF9,EDN1,HSPB8,ADIPOQ	4	
Liver Enlargement, Liver Hepatomegaly	hepatomegaly	hepatomegaly	2.51E-01	 	 	 	 	MIF,CTSA,GBA,ENTPD5,ADIPOQ,SMPD1,INSR,STAT1,ESR2	9	
Liver Fibrosis	migration	migration of hepatic stellate cells	2.51E-01	 	 	 	 	MIF,SPP1,EDN1	3	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	incidence	incidence of hepatocellular carcinoma	2.54E-01	 	-1.408	bias	 	TP53,LEP,ENTPD5,HRAS,ANXA7,SOD1	6	
Cardiac Proliferation	proliferation	proliferation of cardiomyocytes	2.61E-01	 	-1.380	 	-1.512	CXCL10,HMOX1,ADAM17,PLCE1,LEP,EDN1,KIT,FGF1,NACA	9	
Liver Inflammation/Hepatitis	alcoholic hepatitis	alcoholic hepatitis	2.63E-01	 	 	 	 	CXCL10,ADORA1,FAS,GSTP1	4	
Cardiac Inflammation	inflammation	inflammation of heart	2.68E-01	 	0.600	bias	1.373	TRAF3,AGER,PNKD,PPIA,CSF1R	5	
Cardiac Arrythmia	atrial fibrillation	atrial fibrillation	2.68E-01	 	 	 	 	VCAM1,TIMP1,TUBB4B,KCNMA1,TUBG1,TUBB2A,DGAT2,P2RY12,ANXA7,TUBA1C,PPP1CA,ADRA1A	12	
Cardiac Arrythmia, Congenital Heart Anomaly	Romano-Ward syndrome	Romano-Ward syndrome	2.75E-01	 	 	 	 	CALM1 (includes others),SNTA1	2	
Renal Dilation	dilation	dilation of renal tubule	2.75E-01	 	 	 	 	ARHGDIA,APRT	2	
Glutathione Depletion In Liver, Liver Fibrosis	production	production of reactive oxygen species in liver	2.75E-01	 	 	 	 	UBQLN1,SMPD1	2	
Cardiac Fibrosis	fibrosis	fibrosis of heart	2.78E-01	 	0.545	 	1.421	PTX3,APOE,SPP1,PFKFB1,SGCG,NPY1R,EGR1,RRM2B,CTNNA1,HSPB8,HRAS,PDGFC,PLA2G2A,HMOX1,CAPNS1,TIMP1,PNKD,CYBB,ADORA1	19	
Liver Cholestasis	cholestasis	cholestasis	2.78E-01	 	 	 	 	ABCB6,SCD,SLC25A6,CD68,AKR1C3,SLC12A2,ABCC1,ABCC3,GJB2,FAS	10	
Cardiac Output	cardiac index	cardiac index	2.81E-01	 	 	 	 	ENG	1	
Cardiac Inflammation	endocarditis	endocarditis	2.81E-01	 	 	 	 	ITGB2	1	
Hepatocellular Peroxisome Proliferation	formation	formation of peroxisome membrane	2.81E-01	 	 	 	 	PEX3	1	
Liver Inflammation/Hepatitis	hepatitis A	hepatitis A	2.81E-01	 	 	 	 	IL2RG	1	
Decreased Levels of Potassium	uptake	increased uptake of K+	2.81E-01	 	 	 	 	FAS	1	
Liver Damage	injury	injury of hepatocytes	2.81E-01	 	 	 	 	EGR1	1	
Cardiac Arrythmia, Congenital Heart Anomaly	long QT syndrome 1	long QT syndrome 1	2.81E-01	 	 	 	 	CALM1 (includes others)	1	
Renal Inflammation, Renal Nephritis	lupus-like autoimmune nephritis	lupus-like autoimmune nephritis	2.81E-01	 	 	 	 	NFE2L2	1	
Kidney Failure	nephrotoxic acute renal failure	nephrotoxic acute renal failure	2.81E-01	 	 	 	 	HMOX1	1	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	progressive crescentic glomerulonephritis	2.81E-01	 	 	 	 	VCAM1	1	
Heart Failure	heart failure	severe heart failure	2.81E-01	 	 	 	 	CAMK2D	1	
Congenital Heart Anomaly	atrial septal defect	atrial septal defect	2.83E-01	 	-1.982	bias	 	ACKR3,FLNA,TGFB2,SLC19A1,MEGF8	5	
Renal Damage, Renal Tubule Injury	damage	damage of renal tubule	2.99E-01	 	 	 	 	TP53,CCR1,APOE,EDN1,THBS1	5	
Liver Hyperplasia/Hyperproliferation	incidence	incidence of liver tumor	3.05E-01	 	-1.673	bias	 	TP53,RBM38,LEP,ENTPD5,HRAS,ANXA7,SOD1	7	
Increased Levels of Creatinine	clearance	increased clearance of creatinine	3.06E-01	 	 	 	 	ARHGDIA,APRT	2	
Cardiac Dysfunction	dysfunction	dysfunction of left ventricle	3.18E-01	 	 	 	 	PTX3,TIMP1,CYBB	3	
Cardiac Hypertrophy	hypertrophy	hypertrophy of right ventricle	3.18E-01	 	 	 	 	APOE,PDGFA,GAA	3	
Liver Steatosis	hepatic steatosis	hepatic steatosis	3.24E-01	 	0.289	 	1.400	APOE,SCD,LEP,APOB,DDIT3,ADIPOQ,LGALS9,PDGFC,PNRC2,POR,HMOX1,PLIN2,ATF4,ADORA1,TP53,RBM38,SPP1,UCP2,GPS2,FGFR2,SOD1,NFE2L1,PCCA,NR4A1,CD14,INSR,CYP4A11,SIRPA,GSTP1	29	
Cardiac Arrythmia	supraventricular arrhythmia	supraventricular arrhythmia	3.26E-01	 	 	 	 	VCAM1,TUBB4B,KCNMA1,TIMP1,TUBG1,TUBB2A,DGAT2,P2RY12,TUBA1C,ANXA7,ADORA1,PPP1CA,ADRA1A	13	
Liver Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of liver	3.36E-01	 	 	 	 	TIMP1,SOD1	2	
Renal Necrosis/Cell Death	survival	survival of glomerular cells	3.36E-01	 	 	 	 	CCNI,FAS	2	
Cardiac Dysfunction	diastolic dysfunction	diastolic dysfunction of left ventricle	3.38E-01	 	 	 	 	CYBB	1	
Liver Hyperplasia/Hyperproliferation	hepatoblastoma	hepatoblastoma	3.38E-01	 	 	 	 	TP53	1	
Decreased Levels of Albumin	uptake	increased uptake of albumin	3.38E-01	 	 	 	 	FLNA	1	
Cardiac Dysfunction	left ventricular systolic dysfunction	left ventricular systolic dysfunction	3.38E-01	 	 	 	 	CYBB	1	
Liver Fibrosis	mitogenesis	mitogenesis of hepatic stellate cells	3.38E-01	 	 	 	 	FGF2	1	
Renal Necrosis/Cell Death	survival	survival of mesangial cells	3.38E-01	 	 	 	 	FAS	1	
Glomerular Injury, Renal Thrombosis	thrombosis	thrombosis of glomerular capillary	3.38E-01	 	 	 	 	APOE	1	
Cardiac Fibrosis	fibrosis	fibrosis of heart ventricle	3.40E-01	 	 	 	 	PTX3,CTNNA1,CYBB	3	
Liver Cholestasis	intrahepatic cholestasis	intrahepatic cholestasis	3.44E-01	 	 	 	 	ABCB6,SCD,SLC25A6,CD68,AKR1C3,SLC12A2,GJB2	7	
Renal Necrosis/Cell Death	apoptosis	apoptosis of tubular cells	3.74E-01	 	-1.964	 	-1.709	GLIS2,UNC5B,HIF1A,ADORA1	4	
Liver Damage, Liver Inflammation/Hepatitis	chronic hepatitis	chronic hepatitis	3.83E-01	 	 	 	 	PTPRC,POR,LEP,SPP1,TIMP1,GAA,TNFRSF10B,ADIPOQ,LGALS9,FKBP1A,STAB1,INSR	12	
Liver Adhesion	adhesion	adhesion of hepatocytes	3.91E-01	 	 	 	 	VCAM1	1	
Liver Damage, Liver Inflammation/Hepatitis	chronic autoimmune hepatitis	chronic autoimmune hepatitis	3.91E-01	 	 	 	 	PTPRC	1	
Renal Dilation	dilation	dilation of collecting tubule	3.91E-01	 	 	 	 	ARHGDIA	1	
Cardiac Dysfunction	dysfunction	dysfunction of cardiomyocytes	3.91E-01	 	 	 	 	ALDH2	1	
Heart Failure	end stage heart failure	end stage heart failure	3.91E-01	 	 	 	 	PARK7	1	
Liver Fibrosis	experimentally-induced hepatic fibrosis	experimentally-induced hepatic fibrosis	3.91E-01	 	 	 	 	SPP1	1	
Increased Levels of Albumin	excretion	increased excretion of albumin	3.91E-01	 	 	 	 	P2RX7	1	
Cardiac Inflammation	rheumatic carditis	rheumatic carditis	3.91E-01	 	 	 	 	ANXA1	1	
Liver Steatosis	hepatic steatosis	severe hepatic steatosis	3.91E-01	 	 	 	 	UCP2	1	
Renal Transformation	transformation	transformation of kidney cells	3.91E-01	 	 	 	 	HRAS	1	
Cardiac Arrythmia	ventricular extrasystole	ventricular extrasystole	3.91E-01	 	 	 	 	NHLH1	1	
Cardiac Output	cardiac output	cardiac output	3.92E-01	 	 	 	 	APOE,HRAS,INSR,ADRA1A	4	
Increased Levels of Creatinine	quantity	increased quantity of creatinine	3.92E-01	 	 	 	 	AGER,SLC14A1,ST6GALNAC2,AKR1B1	4	
Renal Proliferation	proliferation	proliferation of kidney cells	4.10E-01	 	-1.118	 	-1.437	CXCL10,APOE,EDN1,AGER,FCER1G,CXCL9,AKR1B1	7	
Nephrosis	familial nephrotic syndrome	familial nephrotic syndrome	4.23E-01	 	 	 	 	PLCE1,ARHGDIA	2	
Liver Proliferation	quantity	quantity of hepatocytes	4.23E-01	 	 	 	 	TP53,ATF4	2	
Liver Steatosis	nonalcoholic fatty liver disease	nonalcoholic fatty liver disease	4.26E-01	 	 	 	 	LEP,UCP2,PLIN2,ADIPOQ,SOD1,CYP4A11	6	
Renal Damage	reperfusion injury	reperfusion injury of kidney	4.28E-01	 	 	 	 	THBS1,UNC5B,C3AR1	3	
Heart Failure	acute decompensated heart failure	acute decompensated heart failure	4.39E-01	 	 	 	 	NPR3	1	
Kidney Failure	acute tubular necrosis	acute tubular necrosis	4.39E-01	 	 	 	 	SPP1	1	
Renal Necrosis/Cell Death	anoikis	anoikis of kidney cell lines	4.39E-01	 	 	 	 	RAC1	1	
Congenital Heart Anomaly	bicuspid aortic valve	bicuspid aortic valve	4.39E-01	 	 	 	 	PLCE1	1	
Increased Levels of Bilirubin	quantity	increased quantity of bilirubin	4.39E-01	 	 	 	 	LEP	1	
Cardiac Infarction	non-ST elevation myocardial infarction	non-ST elevation myocardial infarction	4.39E-01	 	 	 	 	P2RY12	1	
Liver Damage	reperfusion injury	reperfusion injury of liver	4.39E-01	 	 	 	 	HMOX1	1	
Cardiac Necrosis/Cell Death	survival	survival of ventricular myocytes	4.39E-01	 	 	 	 	ADIPOQ	1	
Liver Hypoplasia	hypoplasia	hypoplasia of liver	4.47E-01	Decreased	-2.000	bias	 	TCEA1,ERN1,ATF4,MAFG	4	
Cardiac Arrythmia	arrhythmogenic right ventricular dysplasia	arrhythmogenic right ventricular dysplasia	4.51E-01	 	 	 	 	SNTA1,DMD	2	
Congenital Heart Anomaly	transposition	transposition of great vessels	4.51E-01	 	 	 	 	DVL1,DVL3	2	
Kidney Failure	end stage renal disease	end stage renal disease	4.52E-01	 	-1.720	bias	 	SLC7A11,LGMN,SGCG,GLIS2,FCGR2A,ADIPOQ,FKBP1A,ADORA1,GSS,APRT,FCGR3A/FCGR3B,CD151	12	
Liver Damage, Liver Inflammation/Hepatitis	chronic viral hepatitis	chronic viral hepatitis	4.54E-01	 	 	 	 	POR,LEP,SPP1,TIMP1,GAA,TNFRSF10B,ADIPOQ,LGALS9,INSR	9	
Cardiac Dilation	dilation	dilation of left ventricle	4.65E-01	Decreased	-2.000	 	-1.726	GAB2,CAPNS1,SPP1,TIMP1	4	
Glutathione Depletion In Liver	conjugation	conjugation of glutathione	4.78E-01	 	 	 	 	MIF,GSTP1	2	
Renal Inflammation, Renal Nephritis	crescentic glomerulonephritis	acute phase crescentic glomerulonephritis	4.83E-01	 	 	 	 	VCAM1	1	
Increased Levels of Albumin	localization	increased localization of albumin	4.83E-01	 	 	 	 	FCGRT	1	
Liver Regeneration	regeneration	regeneration of liver	4.89E-01	 	0.728	bias	-0.331	SOCS3,LEP,IL1RN,EGR1,NFE2L2,C3AR1,ODC1	7	
Kidney Failure	chronic renal failure	chronic renal failure	4.90E-01	 	-1.720	bias	 	APOB,SLC7A11,SGCG,FCGR2A,ADIPOQ,FKBP1A,GSS,APRT,LGMN,GLIS2,P2RY12,ADORA1,FCGR3A/FCGR3B,CD151	14	
Cardiac Arrythmia	arrhythmia	arrhythmia of heart ventricle	4.95E-01	 	-0.692	bias	0.315	CALM1 (includes others),SNTA1,ANXA7,NHLH1,ASPH,P2RX7,LCP2,ADRA1A	8	
Renal Atrophy	atrophy of kidney	atrophy of kidney	5.00E-01	 	-1.939	bias	 	LGMN,GLIS2,APRT,CD151	4	
Cardiac Arrythmia	Brugada syndrome	Brugada syndrome	5.04E-01	 	 	 	 	KCND3,SNTA1	2	
Glomerular Injury, Renal Damage	injury	injury of renal glomerulus	5.04E-01	 	 	 	 	CCR1,FGF2	2	
Liver Cholestasis	progressive familial intrahepatic cholestasis type 1	progressive familial intrahepatic cholestasis type 1	5.06E-01	 	 	 	 	ABCB6,SCD,SLC25A6,AKR1C3,SLC12A2	5	
Heart Failure	cardiac death	cardiac death	5.24E-01	 	 	 	 	P2RY12	1	
Liver Inflammation/Hepatitis	fulminant hepatitis	fulminant hepatitis	5.24E-01	 	 	 	 	FAS	1	
Cardiac Stenosis	non-rheumatic aortic stenosis	non-rheumatic aortic stenosis	5.24E-01	 	 	 	 	VCAM1	1	
Renal Necrosis/Cell Death	apoptosis	apoptosis of renal tubular epithelial cells	5.29E-01	 	 	 	 	GLIS2,UNC5B	2	
Congenital Heart Anomaly	atrioventricular septal defect and common atrioventricular junction	atrioventricular septal defect and common atrioventricular junction	5.29E-01	 	 	 	 	TGFB2,SLC19A1	2	
Heart Failure	chronic heart failure	chronic heart failure	5.32E-01	 	 	 	 	CA3,CA5B,ADRA1A	3	
Cardiac Hypertrophy	hypertrophy	hypertrophy of left ventricle	5.40E-01	 	-1.000	bias	-0.135	LEP,GAA,PLIN5,FKBP1A,HMGA1,ESR2,ADRA1A	7	
Glomerular Injury, Renal Necrosis/Cell Death	apoptosis	apoptosis of mesangial cells	5.54E-01	 	 	 	 	APOE,GFPT1	2	
Hepatocellular Carcinoma, Liver Hyperplasia/Hyperproliferation	development	development of hepatocellular carcinoma	5.54E-01	 	 	 	 	JUN,PDGFC	2	
Cardiac Arrythmia	Brugada syndrome type 1	Brugada syndrome type 1	5.62E-01	 	 	 	 	SNTA1	1	
Glomerular Injury, Renal Atrophy	atrophy	atrophy of renal glomerulus	5.62E-01	 	 	 	 	GLIS2	1	
Renal Atrophy	atrophy	atrophy of renal medulla	5.62E-01	 	 	 	 	APRT	1	
Cardiac Arrythmia	chronic atrial fibrillation	chronic atrial fibrillation	5.62E-01	 	 	 	 	PPP1CA	1	
Cardiac Dysfunction, Heart Failure	diastolic heart failure	diastolic heart failure	5.62E-01	 	 	 	 	NPR3	1	
Liver Hematopoiesis	erythropoiesis	erythropoiesis of liver	5.62E-01	 	 	 	 	FOS	1	
Increased Levels of LDH	activation	increased activation of LDH	5.62E-01	 	 	 	 	FGF2	1	
Glomerular Injury, Renal Damage	injury	injury of podocytes	5.62E-01	 	 	 	 	FGF2	1	
Kidney Failure	ischemic acute renal failure	ischemic acute renal failure	5.62E-01	 	 	 	 	HMOX1	1	
Renal Necrosis/Cell Death	survival	survival of podocytes	5.62E-01	 	 	 	 	CCNI	1	
Liver Inflammation/Hepatitis	hepatitis B	hepatitis B	5.65E-01	 	 	 	 	IL2RG,TIMP1,FCGR2A,TNFRSF10B,FCGR3A/FCGR3B	5	
Cardiac Pulmonary Embolism	pulmonary embolism	pulmonary embolism	5.77E-01	 	 	 	 	F2RL3,P2RY12	2	
Cardiac Pulmonary Embolism	acute pulmonary embolism	acute pulmonary embolism	5.97E-01	 	 	 	 	P2RY12	1	
Glomerular Injury, Renal Fibrosis	fibrosis	fibrosis of renal glomerulus	5.97E-01	 	 	 	 	STAB1	1	
Cardiac Hyperplasia/Hyperproliferation	hyperplasia	hyperplasia of heart	5.97E-01	 	 	 	 	DUSP6	1	
Congenital Heart Anomaly	dextrocardia	dextrocardia	6.00E-01	 	 	 	 	PCSK6,MGAT1	2	
Congenital Heart Anomaly	perimembranous ventricular septal defect	perimembranous ventricular septal defect	6.00E-01	 	 	 	 	ACKR3,TGFB2	2	
Cardiac Arrythmia, Tachycardia	catecholaminergic polymorphic ventricular tachycardia type 1	catecholaminergic polymorphic ventricular tachycardia type 1	6.29E-01	 	 	 	 	CALM1 (includes others)	1	
Cardiac Arrythmia	paroxysmal familial ventricular fibrillation	paroxysmal familial ventricular fibrillation	6.29E-01	 	 	 	 	SNTA1	1	
Cardiac Arrythmia	tachyarrhythmia	tachyarrhythmia	6.29E-01	 	 	 	 	ADRA1A	1	
Cardiac Arrythmia	atrial flutter	atrial flutter	1.00E00	 	 	 	 	KCNMA1,ADRA1A	2	
Cardiac Congestive Cardiac Failure, Heart Failure	congestive heart failure	congestive heart failure	1.00E00	 	-1.000	bias	 	SLC7A11,NPR3,ADIPOQ,FKBP1A,STAB1,SOX9,GSS,ADRA1A	8	
Renal Hypoplasia	hypoplasia	hypoplasia of kidney	1.00E00	 	 	 	 	FRAS1,ITGA8,ARHGDIA,RET	4	
Increased Levels of Alkaline Phosphatase	activation	increased activation of alkaline phosphatase	1.00E00	 	 	 	 	TGFBR1,LEP,AGER	3	
Increased Levels of Blood Urea Nitrogen	quantity	increased quantity of blood urea nitrogen	1.00E00	 	 	 	 	AGER	1	
Renal Inflammation, Renal Nephritis	lupus nephritis	lupus nephritis	1.00E00	 	 	 	 	PTPRC,CXCL16,VCAM1,AGER,PSMB2,FCGR2A,PSMD2,FKBP1A,FAS	9	
Cardiac Arrythmia, Tachycardia	tachycardia	tachycardia	1.00E00	 	0.000	 	0.453	PTGFR,CALM1 (includes others),ANXA7,ASPH,ADORA1,LCP2,ADRA1A	7	
Cardiac Arrythmia, Tachycardia	ventricular tachycardia	ventricular tachycardia	1.00E00	 	 	 	 	CALM1 (includes others),ANXA7,ASPH,LCP2,ADRA1A	5	

Regulator Effects for My Projects->David Bulger->P2
Consistency Score	Node Total	Regulator Total	Regulators	Target Total	Target Molecules in Dataset	Disease & Function Total	Diseases & Functions	Known Regulator-Disease/Function Relationships
14.295	70	9	BAX,CD5,CFB,IFNA1/IFNA13,IRF4,MYOC,PIK3R1,THBS4,TSC2	47	ANXA1,ANXA2,ATF4,C3AR1,CCND2,CCND3,CD4,CD52,CD68,CD83,CST6,CTSD,CTSS,CXCL10,CXCL9,DAB2,EGR1,FOS,HIF1A,HLA-A,HMOX1,HSPB1,HYOU1,IL17RA,IL1RN,IL2RG,IRF5,ISG15,MAPK9,MBP,NFE2L1,NFE2L2,RAB7A,RAC1,RARRES3,SCD,SFRP1,SIGLEC1,SLC7A11,SPP1,STAT1,TGFB2,TIMP1,TLR8,TRAF3,UCP2,VCAM1	14	aggregation of cells,anemia,cell movement of breast cancer cell lines,chemotaxis of myeloid cells,chemotaxis of phagocytes,development of blood cells,engulfment of myeloid cells,engulfment of phagocytes,immune response of leukocytes,killing of bacteria,metabolism of membrane lipid derivative,phagocytosis of blood cells,response of myeloid cells,response of phagocytes	12% (15/126)	
12.481	22	3	CD5,IFNA1/IFNA13,IRF4	13	ATF4,CD4,CXCL10,CXCL9,DDIT3,HSPA8,ISG15,MAPK9,RAB7A,RAC1,SIGLEC1,SPP1,STAT1	5	autophagy,engulfment of phagocytes,homing of leukocytes,migration of tumor cell lines,phagocytosis	0% (0/15)	
12.388	30	9	Alpha catenin,BAX,CFB,FGF2,IL17R,IRF4,OSM,RELA,ROCK2	19	ANXA1,APOE,APP,C3AR1,CXCL10,CXCL9,CYBB,EDN1,LITAF,MAPK9,MIF,RAC1,S100A7,S100A8,SAA1,SPP1,STIM1,TGFB2,THBS1	2	chemotaxis of myeloid cells,chemotaxis of phagocytes	0% (0/18)	
12.043	38	6	FZD9,GDF2,IFNA1/IFNA13,mir-1,PI3K (family),TSC2	24	ADAM12,AKR1C1/AKR1C2,ANXA1,ANXA2,CCND2,CXCL10,CXCL9,EDN1,ENG,FOS,HIF1A,HMOX1,HTRA1,ISG15,NINJ1,PDGFA,S100A11,SCD,SFRP1,SIGLEC1,SPP1,STAT1,TNFRSF10B,UCP2	8	engulfment of myeloid cells,engulfment of phagocytes,immune response of leukocytes,metastasis,migration of antigen presenting cells,migration of phagocytes,phagocytosis of blood cells,response of myeloid cells	23% (11/48)	
9.815	21	7	ACOX1,BACH1,BRCA1,E2F1,PI3K (family),PLIN5,TNFSF10	12	ADIPOQ,CTSB,FTH1,GCLM,HMOX1,HSPB1,JUN,NFE2L2,SQSTM1,STAT1,TP53,UNG	2	degeneration of central nervous system,oxidative stress	7% (1/14)	
9.347	19	4	ACACB,AGPAT2,RARRES2,Ubiquitin	11	ADIPOQ,CRYAB,DDIT3,HSPA4,HSPA5,HSPA9,LEP,MVD,PLIN1,SCD,SREBF2	4	cellular homeostasis,concentration of lipid,synthesis of lipid,Viral Infection	63% (10/16)	
9.242	61	5	ARNT,Hbb-b2,IL5,PIK3R1,THBS4	51	ADAM17,ALDOA,ANXA2,ASS1,ATF4,BHLHE41,C1QA,CCND2,CCND3,CCR1,CD74,CISD1,CLDN1,CTSD,CXCL10,DEGS1,DUSP6,EDN1,ENG,FAS,FOS,FTH1,FTL,G6PD,GAPDH,GCLM,HIF1A,HMOX1,HSPA5,HYOU1,IFI30,IL2RG,INSR,ISG15,ITGAV,LCP2,LEP,LFNG,MKI67,NDUFS4,NFE2L1,NFE2L2,NQO1,PCK2,PKM,PSMB4,SIM1,SLC7A5,TGFB2,TP53,VCAM1	5	autosomal dominant disease,cell movement of breast cancer cell lines,cell proliferation of breast cancer cell lines,metabolism of carbohydrate,organismal death	32% (8/25)	
9.168	34	7	CD5,CFB,GPX1,IRF4,REL,ROCK2,THBS4	22	AGER,APP,C3AR1,CD4,CXCL10,CXCL9,CYBB,HLA-A,IL1RN,JUN,KRT10,MAPK9,PI3,RAC1,S100A7,S100A8,SOD1,SPINK5,SPP1,STAT1,TGFB2,VCAM1	5	chemotaxis of myeloid cells,chemotaxis of phagocytes,hypersensitive reaction,immune response of neutrophils,migration of breast cancer cell lines	11% (4/35)	
9.099	38	4	CD5,HRG,PARP9,POR	29	ABCC3,ANXA5,ASNS,ATF5,CD4,CD52,CD74,CD83,CXCL14,CYP4A11,FCGR3A/FCGR3B,FGF1,GADD45B,HIF1A,HLA-A,HLA-DQA1,HLA-DQB1,HMOX1,IL2RG,ISG15,MAPK9,PRNP,SCD,SDC4,SPP1,SREBF2,STAT1,TIMP1,TLR8	5	cell movement of neutrophils,cell viability,cellular homeostasis,development of blood cells,inflammatory response	15% (3/20)	
8.744	57	5	CFB,Hbb-b2,Ifn,IL5,THBS4	44	ALDOA,ANXA2,ASNS,ASS1,ATF4,C1QA,C3AR1,CCND2,CCND3,CCR1,CD74,CFH,CISD1,CXCL10,DDIT3,DUSP6,EDN1,FAS,FOS,FTH1,FTL,GCLM,HIF1A,HLA-A,HSPA5,HYOU1,IFI30,IL2RG,ISG15,ITGAV,LCP2,LFNG,PKM,PSMB4,PTPRJ,RARRES3,S100A8,SLC7A5,SPP1,STAT1,TGFB2,TP53,TYMP,VCAM1	8	autosomal dominant disease,cell movement of lymphocytes,cell proliferation of breast cancer cell lines,metabolism of carbohydrate,migration of mononuclear leukocytes,Nephritis,organismal death,synthesis of purine nucleotide	18% (7/40)	
8.468	38	6	BAX,FZD9,IFNA1/IFNA13,IL17R,TET2,TNFSF10	27	ANXA2,CD14,CD83,CTSB,CTSD,CTSS,CXCL10,CXCL14,CXCL9,FOS,FTH1,HLA-A,HS6ST1,IL1RN,ISG15,ITGB2,JUN,MTSS1,S100A7,S100A8,SIGLEC1,SPRY4,STAT1,TIMP1,TNFRSF10B,TP53,TRAF3	5	activation of leukocytes,cell movement of granulocytes,degeneration of brain,immune response of cells,organismal death	30% (9/30)	
8.232	49	5	ARNT2,DAP3,INSIG1,mir-122,SIM1	34	AGER,AKR1B1,APOE,CCR1,CD68,CFL2,CXCL10,EGR1,FCGR2A,FKBP1A,G6PD,GIT1,GYS1,H1F0,HLA-A,ICMT,IGFBP4,LCP1,LEP,MAP1B,MT-ATP6,MT-ND1,MT-ND3,MT-ND4,MT-ND5,MT-ND6,PEA15,PFN1,PKM,PLIN2,S100A8,SCD,SLC7A1,TYROBP	10	adhesion of blood cells,binding of cells,cell movement of antigen presenting cells,disorder of basal ganglia,migration of phagocytes,Movement Disorders,quantity of Ca2+,response of granulocytes,size of body,synthesis of carbohydrate	4% (2/50)	
8.165	12	1	GDF2	6	ENG,FOS,HIF1A,HSPB8,NINJ1,SPP1	5	autophagy,cell proliferation of breast cancer cell lines,migration of antigen presenting cells,migration of mononuclear leukocytes,migration of phagocytes	0% (0/5)	
8.004	25	8	AKT1,Alpha catenin,CFB,FGF2,IL17R,IRF4,ROCK2,THBS4	15	APP,C3AR1,CD4,CD74,CXCL10,CXCL9,MAPK9,MIF,RAC1,S100A7,S100A8,SAA1,SPP1,TGFB2,THBS1	2	chemotaxis of granulocytes,chemotaxis of phagocytes	13% (2/16)	
7.906	16	2	HRG,PARP9	10	C1QA,CD74,CD83,CXCL14,FCGR3A/FCGR3B,HLA-DQA1,HLA-DQB1,SPP1,STAT1,TIMP1	4	cell movement of neutrophils,cellular homeostasis,development of blood cells,quantity of carbohydrate	0% (0/8)	
7.906	16	2	BAX,IL17R	10	CTSB,CTSD,CTSS,CXCL10,EDEM1,HLA-A,S100A7,S100A8,TIMP1,TRAF3	4	catabolism of protein,cell movement of myeloid cells,immune response of cells,quantity of lymphocytes	25% (2/8)	
7.526	50	4	CXCL8,Hbb-b2,IL5,THBS4	39	ACKR3,ALDOA,ANXA1,ANXA2,ASNS,ASS1,ATF4,C1QA,CCND2,CCND3,CCR1,CD63,CD74,CISD1,CXCL10,DUSP6,EGR1,FAS,FTH1,FTL,GCLM,HIF1A,HSPA5,HYOU1,IFI30,IL10RA,IL2RG,ITGAV,ITGB2,LCP2,LFNG,NACA,PKM,PSMB4,RAC1,SLC7A5,TGFB2,TGFBR1,VCAM1	7	autosomal dominant disease,cell proliferation of breast cancer cell lines,invasion of tumor,metabolism of carbohydrate,migration of cells,organismal death,proliferation of tumor cells	32% (9/28)	
7.506	20	2	CUL4B,IKBKG	12	CCR1,CTSB,FOS,GRN,HLA-A,IL1RN,ISG15,NAGLU,NME1,SOCS3,SOD1,TPM3	6	cellular degradation,degeneration of cells,degeneration of nervous system,disorder of basal ganglia,Neurodegeneration,quantity of mononuclear leukocytes	8% (1/12)	
6.682	21	2	MITF,T3-TR-RXR	14	AKR1C1/AKR1C2,AKR1C3,ALCAM,APOE,CD151,CTSG,FOS,HIF1A,KIT,ME1,SEMA3C,SOX9,SREBF2,THRSP	5	advanced malignant tumor,cell movement of antigen presenting cells,cell movement of tumor cell lines,growth of lesion,synthesis of lipid	30% (3/10)	
6.656	21	5	ACOX1,BRCA1,CAT,PLIN5,TSC1	13	DDIT3,EGR1,FAS,GSTP1,HMOX1,HSPB1,NFE2L2,POR,SQSTM1,STAT1,TIMP1,TNFRSF10B,TP53	3	degeneration of central nervous system,inflammation of liver,oxidative stress	13% (2/15)	
6.653	26	5	APP,FZD9,GDF2,PI3K (family),THBS4	19	AGER,APOE,CD74,CSF1R,CXCL10,CXCL9,CYBB,ENG,FLNA,HIF1A,MAPKAPK2,NINJ1,PIK3R1,PRNP,S100A8,SIRPA,SPP1,TXN,VCAM1	2	migration of antigen presenting cells,migration of phagocytes	20% (2/10)	
6.647	64	6	26s Proteasome,CBX7,Collagen(s),miR-1-3p (and other miRNAs w/seed GGAAUGU),mir-10,PGR	50	AHCYL1,ANXA2,ATF4,ATP6V1B2,C3AR1,CAPN2,CCND3,CD68,CERS2,CKAP4,CLCN3,CLCN7,COMT,CTSA,CTSB,CTSD,CTSS,CYR61,DDIT3,DYNLL1,EDN1,FOS,G6PD,GAB2,GAS5,GDF15,HIF1A,KLF4,LAMP1,LAMP2,MAF,MBOAT7,MRC2,MTSS1,PDGFA,PREX1,PRNP,PSAT1,SDC4,SGPL1,SLC7A5,SLC9A1,SLC9A3R1,SQSTM1,STAT1,TGFBR1,THBS1,TMSB10/TMSB4X,TP53,TPM3	8	astrocytosis,binding of cells,cytotoxicity,formation of cytoskeleton,gliosis of central nervous system,invasion of tumor cell lines,Movement Disorders,size of body	10% (5/48)	
6.641	17	6	BRCA1,EGR1,MTOR,P38 MAPK,PI3K (family),PLIN5	10	ADIPOQ,GCLM,HMOX1,HSPB1,JUN,NFE2L2,PRDX5,SOD1,SQSTM1,TP53	1	oxidative stress	17% (1/6)	
6.600	24	5	AR,CD28,IL3,LGALS1,MTPN	18	BIN1,BTG2,CCND2,CCND3,CSF1R,EGR1,FGFR2,FOS,HRAS,JUN,MAF,MIF,ODC1,PDGFA,SLC3A2,SOX9,SPP1,TGFB2	1	cell transformation	20% (1/5)	
6.364	14	4	IL1B,KRAS,mir-15,RELA	8	APP,FAS,FGF2,GBA,GM2A,HEXA,KIT,LEP	2	metabolism of glycolipid,metabolism of sphingolipid	25% (2/8)	
6.128	26	5	BRCA1,EGR1,PI3K (family),PLIN5,SP1	18	APOE,ATP6V0C,CD28,FGF2,FLNA,GCLM,HMOX1,HSPB1,JUN,NFE2L2,P2RX7,SMPD1,SNCG,SOD1,SPTB,TGFB2,TGFBR1,TP53	3	endocytosis,organization of organelle,oxidative stress	20% (3/15)	
6.013	66	5	26s Proteasome,IL2,NR1I2,PGR,TFEB	56	AHCYL1,ALAS1,ALDH3A2,APP,ARSA,CCND3,CD160,CLCN7,COMT,CSF1R,CTSA,CTSB,CTSD,CXCL10,CYCS,DDIT3,ENTPD5,FAS,FCER1G,FCGR3A/FCGR3B,FGF2,FGFR2,FOS,GAPDH,GAS5,GBA,GDF15,GSTP1,HEXA,HSPA5,IL2RG,JUN,LAMP1,LCP2,MAF,MBOAT7,NAGLU,NME1,PDGFA,PEA15,POR,PRNP,PSAP,PTPRC,PTPRJ,SCD,SLC9A1,SPP1,SPRED1,SQSTM1,STAT1,TIMP1,TNFRSF10B,TP53,TPP1,TRIB3	5	accumulation of cerebroside,inflammation of liver,lysosomal storage disease,Movement Disorders,size of body	8% (2/25)	
6.000	15	4	AGT,ANGPT2,estrogen receptor,YY1	9	AGER,ANXA1,CAPG,FAS,HMOX1,MIF,MSR1,THBS1,UCP2	2	engulfment of antigen presenting cells,immune response of macrophages	0% (0/8)	
5.814	10	1	mir-15	5	APP,CCND2,FGF1,FGF2,TP53	4	fatty acid metabolism,phosphorylation of protein,quantity of Ca2+,synthesis of lipid	0% (0/4)	
5.667	47	8	BRCA1,CAT,CD3,EGR1,ERN1,Interferon alpha,TSC1,XBP1	36	APP,CD4,CD74,CXCL10,CYCS,DDIT3,ERP29,FAS,FCER1A,FGF2,FKBP1A,GADD45B,HLA-A,HMOX1,HSPA8,HSPB1,IL10RA,IL17RA,IL1RN,IL2RG,INSR,JUN,KIT,LHCGR,NFE2L2,PSAP,PTPRC,PTPRJ,SCD,SOD1,SPP1,STAT1,THBS1,TIMP1,TNFRSF10B,TP53	3	activation of enzyme,oxidative stress,response of liver	17% (4/24)	
5.500	22	1	SPI1	16	C3AR1,CD14,CD68,CSF1R,CTSS,CYBB,FCER1A,FCER1G,HSPA8,IL1RN,ISG15,ITGB2,LYZ,PIK3CG,PTPRC,SPP1	5	concentration of phosphatidic acid,immune response of cells,killing of bacteria,recruitment of phagocytes,response of antigen presenting cells	60% (3/5)	
5.333	15	1	HRG	9	C1QA,C1QB,CD74,CD83,CXCL14,FCGR3A/FCGR3B,HLA-DQA1,SPP1,TIMP1	5	arthropathy,cell movement of neutrophils,cellular homeostasis,quantity of carbohydrate,Rheumatic Disease	0% (0/5)	
5.333	14	3	FOXO1,HIF1A,Ifn	9	ALDOA,CTPS1,CYCS,FAS,INSR,MT-CO3,PKM,SOCS3,TP53	2	biosynthesis of nucleoside triphosphate,biosynthesis of purine ribonucleotide	33% (2/6)	
5.000	24	7	CHUK,CSF2,E2F1,IKBKG,PI3K (family),TCF7L2,TNFSF10	16	CERS2,CSF1R,CTSB,CTSD,FGF2,FGFR2,GRN,HIF1A,IL1RN,JUN,MTMR2,NAGLU,NR4A2,PRNP,SLC1A2,UNG	1	degeneration of neurons	0% (0/7)	
4.536	11	3	EGF,F2,SPP1	7	ADAM17,CYBB,HMOX1,ITGAV,PIK3R1,RAC1,VCAM1	1	migration of myeloid cells	33% (1/3)	
4.359	24	4	CBX7,EIF4E,IL27,let-7a-5p (and other miRNAs w/seed GAGGUAG)	19	CD14,CLDN1,CTSS,CXCL10,EGR1,FGF2,FOS,GDF15,HIF1A,HMGA1,HMOX1,HRAS,ODC1,RHOG,STAT1,TGFBR1,THBS1,TP53,VCAM1	1	invasion of cells	25% (1/4)	
4.333	15	2	BAX,Cdc42	9	CTSB,CTSD,CTSS,CXCL10,FAS,FLNA,HLA-A,TIMP1,TRAF3	4	cell movement of myeloid cells,cell movement of phagocytes,immune response of cells,quantity of lymphocytes	50% (4/8)	
4.123	21	1	miR-16-5p (and other miRNAs w/seed AGCAGCA)	17	ACTR1A,ARL2,CCND3,CFL2,FGF2,HMGA1,HMOX1,JUN,NPR3,PANX1,RTN4,SLC12A2,SLC25A22,SLC38A1,SLC7A1,SQSTM1,UCP2	3	ion homeostasis of cells,size of body,transport of molecule	0% (0/3)	
4.041	19	6	AGT,ANGPT2,IRF4,PI3K (complex),STAT4,TGM2	12	AGER,FAS,FCER1G,HMOX1,ISG15,ITGB2,MIF,MSR1,SIRPA,SMPD1,THBS1,UCP2	1	engulfment of antigen presenting cells	33% (2/6)	
3.928	26	4	CD38,HRAS,IL5,miR-125b-5p (and other miRNAs w/seed CCCUGAG)	21	ANXA2,ARF1,BTG2,CCND2,CISD1,CXCL10,FGF2,FOS,GRN,HIF1A,HSPA5,IGKC,JUN,NQO1,PFN1,PKM,RABL6,SOD1,SPP1,TP53,UBE2I	1	cell proliferation of breast cancer cell lines	25% (1/4)	
3.889	12	3	CXCL8,IKBKB,PIK3R1	8	AGER,ANXA1,CXCL10,FOS,HIF1A,RAC1,TGFBR1,TP53	1	cell movement of breast cancer cell lines	67% (2/3)	
3.771	24	3	CD40LG,Ifn,POR	18	ADAM17,CCR1,CD74,CXCL10,EDN1,EGR1,FAS,FOS,G0S2,HIF1A,HLA-A,HMOX1,JUN,MIF,SPP1,STAT1,TP53,VCAM1	3	cell movement of lymphocytes,proliferation of smooth muscle cells,synthesis of purine nucleotide	11% (1/9)	
3.674	9	1	MTORC1	6	ATF4,KLF4,MBP,PKM,SCD,UCHL1	2	apoptosis of tumor cell lines,proliferation of cells	50% (1/2)	
3.667	12	1	MTPN	9	CCND2,CCND3,ENG,FAS,FOS,JUN,MIF,SPP1,TGFB2	2	cell transformation,cell viability of tumor cell lines	0% (0/2)	
3.606	17	3	CSF1,LDL,SP1	13	APOE,ATP6V0C,CD209,CYBB,FCGR2A,FCGR3A/FCGR3B,HMOX1,HYOU1,P2RX7,SMPD1,SNCG,STAB1,TGFBR1	1	endocytosis	67% (2/3)	
3.536	23	3	CREM,FOS,Ifn	18	ABCC1,APOE,CXCL10,CXCL16,CYCS,FAS,HIF1A,HLA-A,HMOX1,JUN,NR4A1,SOCS3,SPP1,STAT1,THBS1,TIMP1,TP53,VCAM1	2	Lymphocyte migration,synthesis of purine nucleotide	17% (1/6)	
3.536	11	1	EIF4E	8	ATOX1,FGF2,HIF1A,HMOX1,HRAS,ODC1,RHOG,TP53	2	export of molecule,invasion of cells	100% (2/2)	
3.500	43	5	FGF19,MTPN,RICTOR,SHC1,SMARCA4	36	APOE,ASNS,DUSP6,ENG,FAS,FAU,FGFR2,FTH1,GSTP1,HIF1A,IL1RN,JUN,KIFC3,KIT,POMP,PSMA3,PSMA4,PSMA6,PSMB4,PSMC4,RPL38,RPL7A,RPLP0,RPS13,RPS19,RPS21,RPS24,RPS29,RPS5,RPSA,SCD,SLC40A1,SPP1,SQSTM1,THRSP,TXN	2	cell death of osteosarcoma cells,cell viability of tumor cell lines	20% (2/10)	
3.395	22	4	HSF2,IFNA1/IFNA13,NTRK1,PRL	17	ANXA2,APP,CD83,CTSS,CXCL10,CXCL9,FOS,HIF1A,HSPA4,HSPH1,PSME1,RET,SIGLEC1,SOD1,SPP1,STAT1,TP53	1	activation of leukocytes	50% (2/4)	
3.307	38	2	26s Proteasome,HTT	33	APP,CD74,CLCN7,CLDN1,CTSB,CTSD,DUSP6,EGR1,FOS,GPC1,HIF1A,HMGA1,HRAS,HSPA5,HSPA8,JUN,KLF4,LAMP1,NDUFS4,NFE2L2,NR4A1,NR4A2,P2RX7,PLOD3,POR,SFRP1,SLC12A2,SOD1,SPP1,SQSTM1,STAT1,TP53,VCAM1	3	astrocytosis,cytotoxicity,invasion of cells	33% (2/6)	
3.162	16	4	ACOX1,Gsk3,HRAS,STAT1	10	APOE,APP,CD14,CRAT,CTSS,EPHX1,GDF15,HSPA8,PLTP,TP53	2	export of lipid,transport of steroid	25% (2/8)	
3.130	8	1	PCGEM1	5	ALDOA,G6PD,GAPDH,PGD,PKM	2	cell proliferation of tumor cell lines,proliferation of fibroblast cell lines	0% (0/2)	
3.062	29	3	HRAS,miR-125b-5p (and other miRNAs w/seed CCCUGAG),miR-30c-5p (and other miRNAs w/seed GUAAACA)	24	ANXA2,ARF1,BTG2,CAPG,CCND2,CXCL10,FGF2,FLNA,FOS,GRN,HIF1A,IFI30,IGKC,IL1RN,JUN,MYL9,NQO1,P4HA2,PFN1,RABL6,SOD1,SPP1,TP53,UBE2I	2	cell proliferation of breast cancer cell lines,hypersensitive reaction	17% (1/6)	
2.982	24	1	ARNT	19	ADAM17,ALDOA,BHLHE41,CCND2,CLDN1,CTSD,EDN1,ENG,ENO1,G6PD,GAPDH,HIF1A,INSR,ITGAV,LEP,NDUFS4,NQO1,SIM1,TP53	4	differentiation of cells,metabolism of reactive oxygen species,organismal death,organization of cytoplasm	75% (3/4)	
2.887	6	1	DDIT3	3	HMOX1,NFE2L2,TNFRSF10B	2	cell death of malignant tumor,inflammation of liver	100% (2/2)	
2.858	11	4	IFNG,MYC,NFE2L2,RELA	6	ALAS1,APP,FECH,HMOX1,NFE2L1,TSPO	1	metabolism of porphyrin	25% (1/4)	
2.750	22	5	ADRB,IL5,INSR,KRAS,NRF1	16	ARHGDIA,ASNS,C1QA,CCR1,DDIT3,FAS,HIF1A,HMOX1,IL1RN,JUN,LEP,NFE2L2,TOP2A,TP53,TRAF3,VCAM1	1	Nephritis	0% (0/5)	
2.449	10	3	CXCL8,IFNA2,STAT1	6	APOE,CD74,CXCL10,CXCL9,HIF1A,RAC1	1	migration of antigen presenting cells	67% (2/3)	
2.449	9	1	FGF10	6	AGER,ANXA1,ANXA2,CTSB,LFNG,SOX9	2	cell death of tumor,generation of cells	50% (1/2)	
2.357	23	4	CEBPA,miR-122-5p (miRNAs w/seed GGAGUGU),NOS2,PIK3R1	18	ALDOA,ANXA1,ATF4,CCND2,EDN1,FAS,G6PD,HIF1A,HMOX1,MT-CO1,NFE2L1,NFE2L2,PTPRC,SLC40A1,SLC7A1,SLC7A11,SOD1,VCAM1	1	anemia	0% (0/4)	
2.268	11	3	CD40LG,IL1,TP63	7	APOE,APP,FAS,INSR,KIF2A,PLEK,PRNP	1	disassembly of filaments	0% (0/3)	
2.138	18	3	miR-16-5p (and other miRNAs w/seed AGCAGCA),PRKAA2,SIRT1	14	ADIPOQ,CYBB,FGF2,HIF1A,HMOX1,HSPA5,JUN,LEP,MAPT,RTN4,SFRP4,SLC12A2,TP53,UCP2	1	ion homeostasis of cells	0% (0/3)	
1.698	21	3	TFEB,TNFSF11,TP53	17	ACP2,APOE,ARSA,CD14,CLCN7,CTSA,CTSD,FUCA1,GBA,GLB1,GRN,HEXA,IL1RN,NAGLU,PPT1,PSAP,TPP1	1	lysosomal storage disease	0% (0/3)	
1.604	17	2	CEBPB,PML	14	ADIPOQ,ALOX5AP,APOE,CFL1,HLA-A,HLA-DRA,IGKC,IL1RN,JUN,LCP2,MBP,PI3,SPP1,TP53	1	hypersensitive reaction	50% (1/2)	
1.414	11	1	SREBF1	8	CXCL10,DGKQ,FAS,HSPA5,LEP,SCD,THRSP,TP53	2	concentration of phosphatidic acid,quantity of Ca2+	50% (1/2)	
1.250	22	4	ABCB6,CHRM3,EIF2AK4,UCP1	16	ALAS1,ATF4,CLCN3,DDIT3,EGR1,FOS,G6PD,GHITM,GOT1,HMOX1,LEP,MBP,PGD,PSAT1,SRM,TRIB3	3	disorder of basal ganglia,Movement Disorders,synthesis of carbohydrate	25% (3/12)	
1.134	10	2	BRD4,miR-483-3p (miRNAs w/seed CACUCCU)	7	CCND2,CCR1,CD4,ERP29,MAPKAPK2,NME1,SOCS3	1	phosphorylation of protein	0% (0/2)	
0.577	56	5	DAP3,KDM5A,MALSU1,NFkB (complex),TNFSF11	48	ADRA1A,APOE,APP,CAPNS1,CD14,CD74,CYR61,DAB2,DDIT3,EDN1,EGR1,FAS,FGF2,FOS,FTH1,FUCA1,GADD45B,GHITM,GRN,HMOX1,HSPB1,IL1RN,JUN,KCND3,KIT,LAMP2,MT-ATP6,MT-ND1,MT-ND3,MT-ND4,MT-ND5,MT-ND6,NCAM1,NDUFA13,NDUFA2,NDUFS4,NME1,NR1D1,PARK7,SAA1,SDC4,SDHB,SIGMAR1,SPP1,STAT1,TIMP1,TP53,TRIB3	3	activation of enzyme,lysosomal storage disease,Movement Disorders	20% (3/15)	
0.567	33	4	FOS,JUN,TGFB1,TNFSF11	28	ADIPOQ,ADORA1,ADRA1A,ARF1,CD4,CYCS,CYR61,DAB2,DAP,EDN1,FCER1A,FGF2,GADD45B,GSTP1,HSPB1,KIT,LHCGR,MS4A2,NR4A2,PKN1,PTPRC,S100A8,SAA1,SAE1,SDC4,STAT1,TGFBR1,THBS1	1	activation of enzyme	25% (1/4)	
0.180	37	5	ALDH2,DAP3,MYCN,RB1,TRIB3	31	ATF4,DDIT3,EGR1,FGF2,FOS,GAPDH,GHITM,GPS2,HRAS,MT-ATP6,MT-ND1,MT-ND5,MT-ND6,MYL12A,NDUFA13,NDUFA2,NME1,PARK7,PSAT1,PSMB6,RPL17,RPL31,RPS3A,RPS4X,SDHB,SLC1A2,SLC1A4,TP53,TUBA1B,TUBG1,UCHL1	1	disorder of basal ganglia	40% (2/5)	
0.000	39	1	MYC	36	APP,ATF4,ATP13A2,CAPNS1,CAPZB,CRYAB,CSRP2,CYCS,DDIT3,EGR1,FBL,FECH,FOS,FTH1,GAPDH,HMOX1,HSPB1,JUN,LAMP1,LAMP2,LDHB,LEP,MBP,NME1,PFKFB1,PKM,PPIA,PSAT1,SOX9,SPP1,SRD5A1,SRM,SUMO3,TP53,TSPO,TXN	2	disorder of basal ganglia,metabolism of porphyrin	0% (0/2)	
0.000	5	1	NEK7	3	CXCL10,EDN1,LMO4	1	inflammation of joint	0% (0/1)	
-2.191	32	1	TNF	30	APOE,APP,ARHGDIB,CCND2,CCND3,CRYAB,CSF1R,DVL1,EDN1,ENG,FGFR2,FTH1,GRN,HIF1A,IGKC,INSR,KIT,ODC1,PDE8B,PIK3CG,PRNP,RPSA,RRM2B,SOD1,SOX9,SQSTM1,STAT1,TP53,TRAF3,TUB	1	autosomal dominant disease	100% (1/1)	
-2.985	24	1	HTT	22	APP,BTG3,CRYAB,CSF1R,EGR1,EPB41L3,FGF1,FKBP4,FOS,GAPDH,HRAS,JUN,P2RX7,PFN1,PRKACB,RAB10,SIRPA,SOD1,TP53,TUBB,UCHL1,VAPA	1	microtubule dynamics	100% (1/1)	
-2.985	24	1	AGT	22	ADIPOQ,AGER,ATP2B1,CTSS,CXCL10,EGR1,ENG,FGF2,FOS,HSPB1,INSR,JUN,LEP,MAPT,PDGFA,PFN1,PIK3R1,RAC1,SLC9A1,TGFBR1,TNFRSF12A,TP53	1	microtubule dynamics	100% (1/1)	
-3.162	12	1	MKNK1	10	CYR61,FLNA,FOS,MAP1B,MAPT,MYO5A,NCDN,PLXNB2,SFRP1,TPP1	1	organization of cytoplasm	0% (0/1)	
-4.000	11	1	ATF4	9	DDIT3,EDN1,HSPA5,JUN,MARS,SARS,SEL1L,SLC7A1,WARS	1	metabolism of protein	100% (1/1)	
-4.082	8	1	TFEB	6	APP,ARSA,CLCN7,CTSB,LAMP1,PSAP	1	Cytosis	0% (0/1)	
-4.158	9	1	SOX4	7	CD2,CD74,FCER1G,FOS,HLA-DQB1,IGKC,MBP	1	development of blood cells	100% (1/1)	
-4.158	9	1	HSF2	7	CCT2,CCT5,HIF1A,HSPA4,HSPB1,JUN,TXN	1	cell death of tumor cell lines	0% (0/1)	
-4.491	8	1	SYVN1	6	APP,ATP6AP1,DAB2,ITGAV,PFN1,PTPRJ	1	engulfment of cells	0% (0/1)	
-4.899	8	1	MTORC1	6	ATF4,KLF4,PKM,SCD,SREBF2,UCHL1	1	apoptosis	100% (1/1)	
-4.919	7	1	mir-210	5	ABCC3,MNT,NCAM1,PSAP,UBQLN1	1	cell viability	100% (1/1)	
-5.307	8	1	IL13	6	CTSB,FCGR2A,IL1RN,PDGFC,SOCS3,SPP1	1	Cytosis	100% (1/1)	
-6.000	6	1	MAFF	4	ABCC3,GSTP1,NQO1,TXNRD1	1	cell death	0% (0/1)	
-16.743	5	1	GNE	3	ASNS,DDIT3,TRIB3	1	cell death of tumor cell lines	100% (1/1)	
-16.743	5	1	MYC	3	CTSD,LEP,LYZ	1	hydrolysis of polysaccharide	0% (0/1)	
-25.981	5	1	CST5	3	ABCC1,ARHGEF2,MAP1B	1	disassembly of filaments	0% (0/1)	
Networks for My Projects->David Bulger->P2
ID	Analysis	Molecules in Network	Score	Focus Molecules	Top Diseases and Functions	
1	P2	ADAP2,APP,ARMC9,ATRAID,BHMT2,C9orf142,CHID1,DENND1C,DHRS7B,DHRSX,DIRAS1,FAM49A,FDX1L,GLOD4,HIGD2A,IGSF6,IMP4,JTB,KIAA1191,KRTCAP2,LARP6,LHFPL2,LURAP1L,MRPL52,PCIF1,PDZD4,PNRC2,RIMS4,RNF24,SH3BGRL3,SLC48A1,SPX,TMEM53,TOMM5,TOX2	43	35	Cancer, Cellular Development, Cellular Growth and Proliferation	
2	P2	ABCB6,AHCYL1,BCAP29,BCAP31,CCR1,CKAP4,DCLK2,DHX8,EIF5A,ENO1,FBL,FIS1,GALNT4,GXYLT2,HIST2H2AB,IL17RA,KNSTRN,LDHB,MSC,N-Cadherin,NACA,NAP1L4,RCC2,RNF144A,SIM1,SLC25A39,SNRNP25,STS,SZRD1,UBA1,UBE2K,UROS,UTP15,UTP18,ZNF629	41	34	Cell Signaling, Cellular Function and Maintenance, Vitamin and Mineral Metabolism	
3	P2	AASS,ANAPC11,COPS3,COPS4,COPS7A,COPS8,DCUN1D5,E3 RING,GULP1,ICT1,ITGB2,KLHL42,LAGE3,MALSU1,MRPL17,MRPL24,MRPL37,MRPL39,MRPL51,MRPS15,MRPS24,MRPS30,MRPS6,NGRN,NRBP1,RBX1,RHOBTB2,RPUSD3,SUPV3L1,TCEB2,TP53RK,TRUB2,TSPYL5,VHL-Cul2-Elongin-RBX1,WSB1	38	33	Cellular Assembly and Organization, Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance	
4	P2	ANLN,ANXA7,ATP6V1A,CAPZB,CNBP,FLNC,FLOT1,HADHB,KCND3,NMT2,PAFAH1B2,PHLDB2,PLD3,PLEKHO2,Pdgfr,RPL12,RPL17,RPL18A,RPL26,RPL31,RPL35,RPL36,RPL4,RPL7A,RPLP0,RPLP1,SGCG,SORBS1,STEAP3,STOX1,TMEFF1,TSN,TUBA1C,TUBB2A,mediator	38	33	Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function	
5	P2	AES,APITD1/APITD1-CORT,ASNS,BTBD11,CBX4,CCNI,CDK16,COL5A2,CSRP2,CSRP2BP,CTBP1,Collagen type III,DEAF1,DVL1,EFR3A,FANCE,FHL1,GATAD2A,HIST1H4C,HOXA7,HOXB5,HRAS,Hat,INTS1,ITGAV,ITSN1,LMO4,MBD3,MBD4,NCDN,OSGIN1,PPP1R18,TSGA10,ZBTB16,ZNF219	38	33	Skeletal and Muscular System Development and Function, Connective Tissue Disorders, Developmental Disorder	
6	P2	ABHD4,ADCK3,AIFM2,CES2,CHCHD4,CISD1,COA3,COP I,COX14,COX17,COX7B,CstF,FMO1,GLIPR1,KCNG1,LETM1,ME1,ME2,MFAP4,MOCOS,MT-CO1,MT-CO2,MT-CO3,MZT2B,NDUFA4,NINJ1,PRELID1,PROSC,SCO2,SCPEP1,SMIM20,SURF1,TMEM127,TP53,cytochrome-c oxidase	36	32	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
7	P2	AAK1,AP3D1,ASNA1,ATP13A2,Alpha 1 antitrypsin,BTG3,CLCN3,CLGN,EDEM1,EMC6,EMC7,ERN1,FBXL14,FOXRED2,GANAB,GDE1,GHITM,HYOU1,JMJD8,MAN1B1,MLH3,MYL12B,OST4,PDIA6,PLEKHM2,RAB9A,RABL6,SEC61A1,SEC61B,SEL1L,SERINC2,SRC (family),STT3A,TMBIM6,nicotinic acetylcholine receptor	36	32	Molecular Transport, Protein Synthesis, Protein Trafficking	
8	P2	14-3-3,ADAM12,ADRA1A,AIP,Alpha tubulin,CAMK2D,CCT2,CCT5,CHMP1A,EEF1D,ERAP2,G0S2,GABARAP,HNRNPA0,HSPA8,IRAK1,ISG15,LGMN,MAL2,Metalloprotease,PDCL3,PHB2,PSMA3,PSMD2,RPL18,RPL30,RPL38,STIP1,SUMO3,TARS,TUBB,TUBB4B,VCAM1,VDAC1,tubulin (complex)	34	31	Dermatological Diseases and Conditions, Cell Death and Survival, Protein Synthesis	
9	P2	ARL8B,CD160,CLCN7,CLIP1,COL16A1,DAPK2,ENAH,FARS2,FARSA,FARSB,FOLR2,FOS,GAS5,GBA,GM2A,HEXA,INTERLEUKIN,KIF2A,KIF5B,Mir122a,b,OSTM1,PCDH19,PXK,RFNG,SLC19A1,Sos,TAX1BP3,TBCA,TLN2,TPP1,TTL,XPO6,XYLT1,ornithine decarboxylase,phenylalanine-tRNA ligase	32	30	Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	
10	P2	AACS,ADCY2,ADRB,ALOX5AP,AP1B1,AP2S1,Ap1 gamma,Arnt-Hif1a,BHLHE41,BMP2K,BMPER,C6,C8,CMA1,CPA3,CPEB1,DTYMK,FAM127B,LACTB,MPC1,MSMO1,NPL,NR2F6,NRROS,PEG10,PLPP1,PRELP,RASD1,SCYL2,SLC7A11,SLC7A2,SLCO2B1,SRM,TMSB10/TMSB4X,Vegf	32	30	Cellular Assembly and Organization, Cellular Function and Maintenance, Lipid Metabolism	
11	P2	AIF1,Ampa Receptor,C1QBP,Cytochrome bc1,DMXL2,GLUL,ISCU,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND5,Mitochondrial complex 1,NADH dehydrogenase,NCAM1,NDUFA1,NDUFA11,NDUFA12,NDUFA13,NDUFA2,NDUFA4L2,NDUFA6,NDUFA9,NDUFAB1,NDUFB2,NDUFB4,NDUFS3,NDUFS4,NFE2L1,NLGN1,NMDA Receptor,SIGMAR1,SIPA1L1,STOML2,UQCR10	32	30	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
12	P2	ATXN2L,COMMD1,COMMD2,COMMD9,CRYAB,DNAJ,DNAJB11,DNAJC1,DNAJC4,Focal adhesion kinase,G3BP2,HSP,HSPA13,HSPA2,HSPA4,HSPA9,HSPB8,HSPH1,Hdac,Hsp22/Hsp40/Hsp90,KCTD13,LGALS2,MS4A2,PIP,PLEKHM1,RAB5C,RAB7A,RILP,RNASE1,RNASE6,RNH1,RNase A,TRMT112,VPS11,WDR36	30	29	Cellular Assembly and Organization, Cellular Function and Maintenance, Cellular Movement	
13	P2	CD209,EIF2AK1,Eif2,FAU,Fc receptor,Gef,IGSF8,OGFOD1,PLCE1,RPS10,RPS12,RPS13,RPS15,RPS15A,RPS16,RPS19,RPS2,RPS21,RPS23,RPS24,RPS27L,RPS29,RPS3A,RPS4X,RPS5,RPS8,RPSA,Ras homolog,Ribosomal 40s subunit,Rnr,SENP3,TNS1,TUBG1,ZFAND3,ZNF358	30	29	Cancer, Cell Death and Survival, Organismal Injury and Abnormalities	
14	P2	BARD1,CBX3,CSNK1A1,CTSD,DCTPP1,DDX20,EMD,EPRS,ERICH2,FTH1,IARS,ITGA7,KCTD1,KPNA2,MARS,MKI67,MT-TY,MYBBP1A,PPT1,PRDX5,PSAP,RNA polymerase iii,RRP1B,SDCBP,SLC25A1,Shc,TIP60,TOP2A,TRIM28,WHSC1,YARS,ZBTB7B,alcohol group acceptor phosphotransferase,histone deacetylase,thymidine kinase	30	29	Developmental Disorder, Hereditary Disorder, Metabolic Disease	
15	P2	BTF3L4,Cyclin B,DNA-directed RNA polymerase,EDF1,GADD45B,GAPDH,HIF1A,HIST1H2AC,Holo RNA polymerase II,MINOS1,NDUFC2,NELFB,NELFE,NRN1,OGT,OSCP1,PARK7,PCDHAC2,PEA15,PFKL,PGAM1,POLR2G,POLR2I,POLR2K,POLRMT,Pgk,RNA polymerase II,RPA,RPA4,SLC40A1,TAF10,TAF6,TCEA1,TCEA3,UNG	30	29	Carbohydrate Metabolism, Gene Expression, Cell Death and Survival	
16	P2	ACOT4,APC (complex),CD28,CD3,CKAP2,CaMKII,ENOPH1,FBXO28,GIT1,GSTP1,H2AFZ,HINT1,HMGA1,HNRNPK,HSPA5,Histone h3,KDM1B,KIT,LARP4,MGAT1,MTMR2,ODC1,PIK3R1,PKM,PNO1,PRNP,RAB10,SBF1,SDF2,SHP,SHTN1,TCR,UQCR11,VCP,YWHAG	30	29	Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities	
17	P2	ABR,ACSF2,ARHGEF26,ARPC1B,ARPC4,ARPC5,ARPC5L,Arp2/3,CCPG1,CNPY3,Dlg,ELMO,ELMO2,FCGR1A/2A/3A,KIFAP3,LMCD1,LRRC1,MCF2L,MECR,MRPS34,NIPSNAP3A,PCCA,PCCB,PPA2,Phosphatidylinositol4,5 kinase,RAC1,RAP1GDS1,RHOG,SH3RF3,SRGAP1,TENM4,TMED3,TRPM6,Troponin t,Wave	28	28	Developmental Disorder, Hematological Disease, Hereditary Disorder	
18	P2	ALAS1,ALDH,ALDH1L2,ALDH2,ALDH4A1,ALDH5A1,C8orf33,CAR ligand-CAR-Retinoic acid-RXRα,EFS,FAM45A,HNRNPAB,IGHG3,IGKC,IL-2R,IL2RG,JUN/JUNB/JUND,KRTDAP,LRRC8D,LYPLA1,MNT,MS4A7,NPAS2,OXLD1,PSAT1,Ras,SH2B3,SHB,SHOC2,SLC1A4,SLC35F6,SRD5A1,TTC23,UQCC2,aldehyde dehydrogenase (NAD),transglutaminase	28	28	Developmental Disorder, Hematological Disease, Hereditary Disorder	
19	P2	AHSA1,ARHGDIA,ARHGDIB,BRF2,C20orf24,C9orf72,DPH2,DYNLRB1,ELP5,Erm,FAM96B,IPO4,MMS19,MRPS16,MTHFD1L,MYO1D,Mrlc,PHLDA3,PLXNB2,PLXND1,Pak,RAB11FIP2,RNF185,RPN2,Rab11,Rac,Rho gdi,SDHB,SDHC,SSR4,TMEM147,TMEM33,TOP3B,XPO4,succinate dehydrogenase	28	28	Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities	
20	P2	ACP2,ALPL,Betacatenin/TCF,CASKIN1,CDC14B,CITED1,COL15A1,CYGB,Cg,DPT,DUSP10,DUSP4,DUSP6,EDN1,EYA2,FRAS1,FSH,GOT1,INSR,LHCGR,LIMCH1,Lh,MEGF8,NPC2,P4HA2,PGP,PTPRJ,PTPRK,PTPase,RILPL1,SCUBE1,SIRPA,SUSD1,Sod,tyrosine kinase	28	28	Post-Translational Modification, Embryonic Development, Organ Development	
21	P2	CALML3,COASY,DGCR6L,HSPA7,Hsp27,INO80B,KAZN,KIAA0930,KIAA1683,LSM10,LSM4,LZTS2,MAPKAPK2,MCRS1,NHP2,P110,PNMA1,PRKRA,PRMT5,Pik3r,Plk,RET,SMIM3,SNRPA,SNRPC,SNRPD2,SNRPF,SNU13,TFPT,TXNL4A,Trk Receptor,URB1,YWHAH,estrogen receptor,snRNP	28	28	Cancer, Cell Cycle, Embryonic Development	
22	P2	AMFR,ARHGAP35,ATP synthase,ATP5D,ATP5G1,ATP5I,ATP5J,ATP5J2,ATP5L,ATP6AP1,ATP6V0B,ATP6V0C,ATP6V1B2,ATP6V1E1,ATP6V1F,ERK,F0 ATP synthase,FRS3,H+-exporting ATPase,METTL23,MT-ATP6,S100,S100A1,S100A11,S100A2,S100A7,SNX10,SPRED1,SUSD3,TESK1,THEMIS2,USMG5,Vacuolar H+ ATPase,adenosine-tetraphosphatase,p38 Sapk	26	27	Molecular Transport, Energy Production, Nucleic Acid Metabolism	
23	P2	ARRDC4,BANF1,C7orf50,ERP29,Glycogen synthase,H1F0,HDGF,HIST1H1B,HIST1H1C,HIST1H1E,HIST1H2BC,HIST1H2BK,HIST1H3J,HIST1H4H,Histone H1,IPO7,Importin alpha,Importin beta,JUN,KPNA1,MVD,P-TEFb,PKN1,Patched,RAN,RNF187,SLBP,SRP19,TNPO1,TRMT10C,Transportin,UBIQUITIN LIGASE,VANGL1,XPO5,XPOT	26	27	Molecular Transport, RNA Trafficking, Protein Trafficking	
24	P2	ACAD11,ALDH3A2,C5orf15,COL5A3,CTDNEP1,Cpla2,DERL1,EPHX1,Ephb,GPC1,IL20RB,ITGA8,Intersectin,MAZ,MKNK2,Mapk,NSMAF,PDGF-AA,PLAA,RNF167,RSPO1,RSPO3,SDC3,SGPL1,SRPRA,SRPRB,Syndecan,THEM6,TMX2,TTC1,Tenascin,UBXN6,ZFAND2B,ZNRF3,sphingomyelinase	26	27	Lipid Metabolism, Small Molecule Biochemistry, Cancer	
25	P2	AKR1B1,AKR1C1/AKR1C2,AKR1C3,ALDOA,AOX1,Aldose Reductase,BCOR,CBR1,Cbp/p300-Maf-Nfe2l2,Ces,DPP3,ENTPD5,FTL,G6PD,GSPT1,IKK (complex),KEAP1,MAF,MSR1,NAA10,NADH or NADPH:quinone oxidoreductase,NARS,NDUFAF3,NFE2L2,NQO1,OTUB2,PDLIM4,RBCK1,SCAVENGER receptor CLASS A,TALDO1,THRSP,TRIM55,TSC22D2,glutamylcysteine synthetase gamma,glutathione peroxidase	26	27	Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry	

My Lists for My Projects->David Bulger->P2
My Lists	 -log(p-value)	Ratio	Molecules 

Tox Lists for My Projects->David Bulger->P2
Ingenuity Toxicity Lists	 -log(p-value)	Ratio	Molecules 
Mitochondrial Dysfunction	1.66E01	2.95E-01	NDUFA9,ATP5D,NCSTN,ATP5L,MT-CO2,NDUFA4L2,NDUFA1,MT-ND2,ATP5J,SURF1,SDHC,UQCR11,MT-ND4L,NDUFA6,MAPK10,NDUFA12,MT-ND3,VDAC1,NDUFS3,NDUFB2,NDUFA4,ATP5G1,SDHB,COX7B,PRDX5,NDUFA2,PARK7,MT-CYB,ATP5J2,MT-CO3,NDUFAB1,ATP5I,NDUFS4,MT-CO1,MT-ATP6,NDUFB4,COX17,MT-ND6,UCP2,COX7A2L,MAPK9,MT-ND4,NDUFA13,APP,FIS1,MT-ND1,MT-ND5,NDUFS8,NDUFA11,UQCR10,CYCS,UQCRQ
NRF2-mediated Oxidative Stress Response	5.57E00	1.72E-01	PIK3R1,MAF,HSPB8,HRAS,MAFG,HMOX1,JUN,DNAJC4,CYP3A5,KEAP1,PIK3CG,ABCC1,VCP,UBE2K,ATF4,FMO1,GCLM,TXN,FKBP5,NFE2L2,CBR1,NQO1,MAPK9,DNAJC1,SOD1,TXNRD1,PIK3R3,FOS,FTL,ERP29,STIP1,RBX1,DNAJB11,SQSTM1,AOX1,CYP4A11,ACTG1,GSTP1,EPHX1,FTH1
Liver Necrosis/Cell Death	5.46E00	1.6E-01	SOCS3,APOE,SCD,GADD45B,AGER,DDIT3,PIK3R1,ADIPOQ,FKBP1A,HRAS,SMPD1,TMBIM6,TAF10,IL17RA,FAS,PTPRC,CXCL10,SLC19A3,HMOX1,ALDH2,JUN,TIMP1,FLNA,SAA1,ENTPD5,ITGAV,CFH,STAT1,NFE2L2,TP53,TYROBP,MAPK9,SOD1,IRF5,NFE2L1,APP,MNT,RBCK1,ITGB2,FOS,LAMP2,IL1RN,CTSB,CD14,DUSP4,SLC25A5
Renal Necrosis/Cell Death	5.39E00	1.38E-01	GFPT1,CRYAB,AGER,CCNI,UNC5B,HRAS,C1QA,HSPA5,APRT,SGPL1,RHOG,ABCC1,MCOLN3,ITGAV,NEO1,RET,DPM3,HK1,TP53,SPP1,GNG2,BCL2L14,TNFRSF10B,RAC1,SDHC,HAX1,MAPT,GAPDH,DUSP4,SFRP1,VDAC1,GSTP1,HSPB1,APOE,CD2,DDIT3,ERN1,FGF2,HYOU1,PPIA,HIF1A,FAS,HMOX1,EDN1,THBS1,ANXA5,VCP,AAK1,SLC40A1,ADORA1,NFE2L2,NDUFAB1,NLRC4,ATP13A2,PRNP,TMEM123,GNA12,TRIB3,SOD1,APP,FGF1,FOS,MYOC,GLIS2,SREBF2,NTRK3,PEA15,CYCS,ABCC3,P2RX7
Persistent Renal Ischemia-Reperfusion Injury (Mouse)	4.19E00	3.33E-01	SOCS3,LYZ,VCAM1,LAPTM5,EDN1,CTSS,C1QC,SOX9,C1QB,HSPB1
Acute Renal Failure Panel (Rat)	3.55E00	2.26E-01	VCAM1,EGR1,GDF15,FKBP1A,ANXA2,TUBB,TNFRSF12A,MYO5A,FOS,HMOX1,JUN,CD68,ANXA1,CD14
Hypoxia-Inducible Factor Signaling	3.5E00	2.14E-01	TP53,UBE2A,PIK3R1,NQO1,HRAS,HIF1A,EIF2S2,UBE2D2,JUN,EDN1,UBE2G1,ASPH,UBE2E1,UBE2D3,UBE2I
Cardiac Hypertrophy	3.49E00	1.27E-01	CRYAB,APOB,PFN1,PFKFB1,PIK3R1,HRAS,SLC9A1,EEF1D,CTSD,PLCE1,CAMK2D,PIK3CG,GAA,CYBB,PNKD,PLIN5,TXN,TP53,MIF,RHEB,RAC1,HMGA1,KLF4,LMCD1,MYL9,MNT,MTPN,CTSB,ESR2,MT-TL1,APOE,FHL1,ADAM17,LEP,PDGFA,FGF2,GDF15,ADIPOQ,HSPB8,PPIA,FKBP1A,DMD,HIF1A,PDGFC,H2AFZ,HMOX1,JUN,EDN1,PARK7,TIMP1,ADORA1,SCNN1B,TRIM55,PRMT5,ADRA1A
Oxidative Stress	3.38E00	2.28E-01	TP53,VCAM1,PRDX5,NQO1,SOD1,ME1,GSS,NFE2L1,S100A7,FOS,JUN,GCLM,NFE2L2
Increases Cardiac Proliferation	3.04E00	2.34E-01	ITGB2,HMOX1,LEP,PLCE1,EDN1,FGF2,ADIPOQ,GNL3,STAT1,NACA,FGF1
Cardiac Necrosis/Cell Death	2.84E00	1.33E-01	SCD,SOCS3,CRYAB,LEP,FGF2,HSPB8,CTSG,ADIPOQ,HIF1A,FAS,IRAK1,C1QTNF9,HMOX1,CAMK2D,PARK7,EDN1,TIMP1,CYBB,STAT1,MAPKAPK2,TP53,HK1,S100A1,THBS4,SPP1,RAC1,KIFAP3,PKN1,MTPN,IL1RN,RTN4,GAPDH,CYR61,ADRA1A,HSPB1,RPSA
Renal Proximal Tubule Toxicity Biomarker Panel (Rat)	2.38E00	2.59E-01	SPP1,TIMP1,ADORA1,SLC38A3,GSTP1,GJB2,HSPB1
Liver Proliferation	2.38E00	1.32E-01	SOCS3,LEP,PIK3R1,ADIPOQ,HRAS,SMPD1,FAS,ODC1,TNFRSF12A,JUN,CCND3,EDN1,TIMP1,THBS1,ENTPD5,CXCL14,ITGAV,SLC7A5,ATF4,STAT1,NFE2L2,TP53,SPP1,FGFR2,MAPK9,FOS,IL1RN,CTSB,INSR,C3AR1
p53 Signaling	2.33E00	1.62E-01	TP53,GADD45B,PIK3R1,RRM2B,TNFRSF10B,HIF1A,FAS,SERPINE2,SCO2,PIK3R3,JUN,CCND2,THBS1,PIK3CG,ADCK3,GNL3
Increases Liver Damage	2.31E00	1.54E-01	MIF,IL2RG,EGR1,MAPK9,SMPD1,FAS,AIP,CERS2,ITGB2,EDN1,IL1RN,KEAP1,SAA1,CTSB,CD14,STAT1,GSTP1,P2RX7
Nongenotoxic Hepatocarcinogenicity Biomarker Panel	2.22E00	2.73E-01	SEL1L,LITAF,BTG2,PPIA,ANXA2,CES2
Increases Depolarization of Mitochondria and Mitochondrial Membrane	1.95E00	2.78E-01	PEBP1,TP53,BTG2,CYR61,PRNP
Decreases Depolarization of Mitochondria and Mitochondrial Membrane	1.85E00	2.31E-01	ABCC1,SH3GLB1,PPIA,VDAC1,FAS,CSTB
Irreversible Glomerulonephritis Biomarker Panel (Rat)	1.8E00	3.08E-01	SPP1,NPR3,CNTNAP1,TMSB10/TMSB4X
TR/RXR Activation	1.8E00	1.53E-01	PIK3R3,ENO1,AKR1C1/AKR1C2,UCP2,AKR1C3,GPS2,SREBF2,PIK3CG,PIK3R1,SYT2,HIF1A,ME1,THRSP
Glutathione Depletion - Hepatocellular Hypertrophy	1.69E00	3.75E-01	POR,FMO1,ABCC3
Recovery from Ischemic Acute Renal Failure (Rat)	1.69E00	2.86E-01	CRYAB,SPP1,TIMP1,TMSB10/TMSB4X
Decreases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	1.59E00	1.34E-01	TP53,UCP2,DDIT3,FGF2,TNFRSF10B,BARD1,MAPK9,FAS,APP,CD28,CISD1,SLC25A6,LGALS2,RTN4,VDAC1,HSPB1
Xenobiotic Metabolism Signaling	1.55E00	1.09E-01	ALDH4A1,AKR1C3,PIK3R1,HS2ST1,MAF,HRAS,CES2,CHST15,CHST2,HS6ST1,HMOX1,CES1,CAMK2D,CYP3A5,KEAP1,ALDH3A2,PIK3CG,CHST11,FMO1,NFE2L2,ALDH5A1,SRA1,AKR1C1/AKR1C2,NQO1,MAPK9,AIP,PIK3R3,FTL,ALDH1L2,PTPA,RBX1,CYP4B1,ABCC3,PPP2R1B,CYP4F11,GSTP1,EPHX1
Increases Heart Failure	1.5E00	2.17E-01	MTPN,CAMK2D,PIK3CG,DUSP6,SLC9A1
Cytochrome P450 Panel - Substrate is a Fatty Acid (Human)	1.41E00	3E-01	CYP4B1,CYP4F11,CYP4A11
Long-term Renal Injury Anti-oxidative Response Panel (Rat)	1.31E00	2.22E-01	HMOX1,GCLM,SOD1,GSS
Aryl Hydrocarbon Receptor Signaling	1.3E00	1.19E-01	TP53,ALDH4A1,NQO1,FAS,AIP,FOS,CTSD,JUN,CCND2,CCND3,ALDH1L2,CYP3A5,ALDH3A2,TGFB2,NFE2L2,ESR2,GSTP1,ALDH5A1,HSPB1
Hepatic Stellate Cell Activation	1.26E00	1.71E-01	TGFBR1,EDN1,PDGFA,TIMP1,TGFB2,CD14
Increases Liver Hepatitis	1.18E00	1.45E-01	ITGB2,SPP1,LEP,CD14,MAPK9,IL17RA,CYR61,FAS
LPS/IL-1 Mediated Inhibition of RXR Function	1.17E00	1.07E-01	APOE,ALDH4A1,HS2ST1,ALAS1,CES2,CHST15,IRAK1,CHST2,HS6ST1,JUN,CYP3A5,ALDH3A2,CHST11,FMO1,HMGCS1,ALDH5A1,ACSL3,MAPK9,ALDH1L2,IL1RN,APOC1,NR5A2,CD14,PLTP,ABCC3,CYP4A11,GSTP1
PXR/RXR Activation	1.12E00	1.36E-01	PRKACB,SCD,PCK2,CYP3A5,ALDH3A2,CES2,INSR,ALAS1,ABCC3
Genes associated with Chronic Allograft Nephropathy (Human)	1.1E00	1.9E-01	VCAM1,PDGFA,THBS1,TIMP1
Increases Cardiac Dysfunction	1.07E00	1.54E-01	PTX3,SCD,PIK3CG,CYBB,FKBP1A,DUSP4
Increases Transmembrane Potential of Mitochondria and Mitochondrial Membrane	1.01E00	1.4E-01	HSPA4,PPP1R1B,FGF2,RAC1,CYCS,ZBTB16,FAS
Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane	9.96E-01	2.86E-01	BTG2,HSPA5
Increases Renal Damage	9.74E-01	1.23E-01	CCR1,TP53,PREX1,MIF,FCGR2A,FGF2,THBS1,RAC1,C1QA,C3AR1
Swelling of Mitochondria	9.57E-01	2E-01	TP53,SOD1,FAS
Pro-Apoptosis	9.52E-01	1.43E-01	TP53,TRAF3,DAPK2,BCL2L14,TNFRSF10B,FAS
RAR Activation	9.3E-01	1.05E-01	PRKACB,SRA1,ADCY2,AKR1C3,PIK3R1,RAC1,MAPK9,RPL7A,PIK3R3,FOS,JUN,PIK3CG,ADCY1,MAPK10,TGFB2,NR2F6,MAPKAPK2,ZBTB16,HLTF,CARM1
Increases Permeability Transition of Mitochondria and Mitochondrial Membrane	8.94E-01	2.5E-01	FAM162A,APP
Cholesterol Biosynthesis	8.92E-01	1.88E-01	MVD,PMVK,HMGCS1
Increases Renal Proliferation	8.82E-01	1.09E-01	SDHB,FGFR2,HRAS,CXCL9,CSF1R,CXCL10,GRN,MYOC,JUN,PLCE1,SDCBP,EDN1,VDAC1,NDUFAB1,P2RX7
Increases Liver Steatosis	7.38E-01	1.1E-01	HMOX1,APOE,SCD,GPS2,PLIN2,ADIPOQ,CD14,ATF4,PNRC2,PDGFC
Cardiac Fibrosis	7.16E-01	9.84E-02	PTX3,APOE,SPP1,PFKFB1,SGCG,NPY1R,EGR1,RRM2B,CTNNA1,HSPB8,HRAS,PDGFC,PLA2G2A,HMOX1,CAPNS1,TIMP1,CYBB,PNKD,ADORA1
Increases Renal Nephritis	6.95E-01	1.2E-01	CD28,LEP,CD2,FCGR2A,IRF5,FCGR3A/FCGR3B
Positive Acute Phase Response Proteins	6.76E-01	1.33E-01	HMOX1,SAA1,SAA2,C1QB
Cytochrome P450 Panel - Substrate is a Fatty Acid (Rat)	6.68E-01	1.82E-01	CYP4B1,CYP4A11
Fatty Acid Metabolism	6.66E-01	1.03E-01	ALDH4A1,ACAD11,ALDH2,ACSL3,SRD5A1,CYP3A5,ALDH3A2,CYP4B1,HADHB,CYP4F11,CYP4A11,ALDH5A1
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARα	6.6E-01	1.05E-01	PRKACB,FOS,SRA1,JUN,PDGFA,PIK3R1,HRAS,ME1,INSR,AIP
Decreases Respiration of Mitochondria	6.11E-01	1.67E-01	PKM,MAPK9
Glutathione Depletion - CYP Induction and Reactive Metabolites	6.11E-01	1.67E-01	ABCC3,EPHX1
Increases Glomerular Injury	5.83E-01	1.02E-01	CCR1,TP53,GFPT1,MIF,AGER,EDN1,PARK7,FGF2,NUPR1
LXR/RXR Activation	5.72E-01	9.76E-02	APOE,SCD,LYZ,APOB,MSR1,IL1RN,SAA1,APOC1,CD14,S100A8,PLTP,SAA2
Long-term Renal Injury Pro-oxidative Response Panel (Rat)	5.6E-01	1.54E-01	CYBB,FMO1
VDR/RXR Activation	5.59E-01	1.03E-01	CXCL10,SPP1,PDGFA,HOXA10,TGFB2,CD14,CST6,KLF4
Hepatic Fibrosis	5.56E-01	9.9E-02	IGFBP4,SPP1,LEP,EDN1,PDGFA,FGF2,THBS1,TIMP1,TGFB2,FGF1
Protection from Hypoxia-induced Renal Ischemic Injury (Rat)	5.51E-01	2.5E-01	HMOX1
FXR/RXR Activation	5.29E-01	9.52E-02	APOE,APOB,SLC4A2,PCK2,IL1RN,SAA1,MAPK10,APOC1,MAPK9,NR5A2,PLTP,SAA2
Hepatic Cholestasis	4.96E-01	9.15E-02	PRKACB,ADCY2,SLC4A2,MAPK9,IRAK1,JUN,IL1RN,ABCC1,ADCY1,TGFB2,MAPK10,CD14,NR5A2,INSR,ABCC3
Increases Bradycardia	4.74E-01	1.33E-01	RAC1,ADORA1
Genes Upregulated in Response to Chronic Renal Failure (Rat)	4.71E-01	2E-01	ABCC3
Cytochrome P450 Panel - Substrate is a Fatty Acid (Mouse)	4.37E-01	1.25E-01	CYP4B1,CYP4A11
Increases Cardiac Dilation	4.15E-01	1.07E-01	CAMK2D,RAC1,ADORA1
CAR/RXR Activation	3.91E-01	1.03E-01	GADD45B,CES1,ABCC3
Cytochrome P450 Panel - Substrate is an Eicosanoid (Human)	3.58E-01	1.43E-01	CYP4F11
Increases Liver Hyperplasia/Hyperproliferation	3.54E-01	8.65E-02	TP53,PEG10,LEP,JUN,MAPK9,HRAS,HSPA5,ODC1,PRNP
Biogenesis of Mitochondria	3.21E-01	1E-01	LETM1,P2RX7
Hormone Receptor Regulated Cholesterol Metabolism	3.16E-01	1.25E-01	ABR
Vasopressin-induced Genes in Inner Medullary Renal Collecting Duct Cells (Rat)	3.16E-01	1.25E-01	PRKACB
Renal Ischemic Resistance Panel (Rat)	2.5E-01	1E-01	SPP1
Genes Upregulated in Response to Proteinuria-induced Oxidative Stress in Renal Proximal Tubule Cells (Human)	2.5E-01	1E-01	COMT
Increases Damage of Mitochondria	2.24E-01	9.09E-02	FAS
Primary Glomerulonephritis Biomarker Panel (Human)	2.24E-01	9.09E-02	EGR1

My Pathways for My Projects->David Bulger->P2
My Pathways	 -log(p-value)	Ratio	Molecules 

Analysis Ready Molecules for My Projects->David Bulger->P2
ID	Symbol	Expr Fold Change	Expr p-value	Expr False Discovery Rate (q-value)
ENSG00000081760	AACS	-2.254764059	1.94E-5	8.74375E-4
ENSG00000115977	AAK1	1.862040668	5.19E-6	2.89798E-4
ENSG00000090861	AARS	3.26375222	1.53E-17	9.35E-15
ENSG00000149313	AASDHPPT	2.815894413	1.02E-8	1.31E-6
ENSG00000008311	AASS	-2.695922023	7.67E-7	5.93E-5
ENSG00000167972	ABCA3	1.740506349	2.28101E-4	0.006523547
ENSG00000115657	ABCB6	1.936890516	2.71023E-4	0.007469328
ENSG00000103222	ABCC1	3.859843278	1.35E-19	9.94E-17
ENSG00000108846	ABCC3	5.109192833	1.23E-14	4.59E-12
ENSG00000161204	ABCF3	1.909559102	8.14E-6	4.22617E-4
ENSG00000100439	ABHD4	3.502636333	1.77E-13	5.58E-11
ENSG00000159842	ABR	1.84446148	1.74E-5	8.01304E-4
ENSG00000240303	ACAD11	2.434583773	3.38E-9	4.92E-7
ENSG00000114331	ACAP2	1.762847658	3.61E-5	0.001458873
ENSG00000144476	ACKR3	2.196594914	1.38657E-4	0.004348244
ENSG00000177465	ACOT4	3.712879999	1.35E-7	1.31E-5
ENSG00000134575	ACP2	1.848799803	1.33503E-4	0.00421988
ENSG00000167107	ACSF2	2.433170063	1.45E-7	1.38E-5
ENSG00000123983	ACSL3	2.789543557	5.01E-8	5.44E-6
ENSG00000066813	ACSM2B	-4.700314	2.42412E-4	0.006822525
ENSG00000183549	ACSM5	-5.103240009	3.18E-8	3.65E-6
ENSG00000111058	ACSS3	-2.558873314	9.82E-5	0.003292791
ENSG00000184009	ACTG1	2.488207878	3.78E-9	5.47E-7
ENSG00000072110	ACTN1	2.347993676	4.16E-9	5.9E-7
ENSG00000138107	ACTR1A	1.85483041	2.15E-5	9.5117E-4
ENSG00000123612	ACVR1C	-3.201997565	4.47E-6	2.60688E-4
ENSG00000148848	ADAM12	2.993923642	1.36E-10	2.63E-8
ENSG00000151694	ADAM17	2.077669577	1.37E-5	6.63275E-4
ENSG00000166106	ADAMTS15	3.093663659	3.22E-10	5.85E-8
ENSG00000154736	ADAMTS5	2.005576506	1.39E-6	9.88E-5
ENSG00000241684	ADAMTS9-AS2	-4.371485413	1.32E-11	3.14E-9
ENSG00000184060	ADAP2	3.713095511	9.28E-11	1.84E-8
ENSG00000133597	ADCK2	2.579344843	2.14272E-4	0.006191084
ENSG00000163050	ADCK3	-2.39860772	1.04E-5	5.22827E-4
ENSG00000164742	ADCY1	7.901744956	6.33E-46	3.02E-42
ENSG00000078295	ADCY2	-2.937278805	6.51E-5	0.002356241
ENSG00000078549	ADCYAP1R1	2.218366158	7.53E-5	0.002634997
ENSG00000121753	ADGRB2	4.243698945	3.61E-10	6.5E-8
ENSG00000111452	ADGRD1	-4.407882711	5.8E-7	4.73E-5
ENSG00000173698	ADGRG2	-2.708762014	2.97E-5	0.001235599
ENSG00000072071	ADGRL1	2.513822728	8.95E-9	1.17E-6
ENSG00000181092	ADIPOQ	-2.333587014	7.27E-5	0.002577249
ENSG00000226482	ADIPOQ-AS1	-2.220105914	2.81944E-4	0.007702586
ENSG00000181915	ADO	2.395973528	1.25469E-4	0.004038095
ENSG00000163485	ADORA1	2.414321956	1.13342E-4	0.003700161
ENSG00000120907	ADRA1A	3.16327645	3.98E-7	3.37E-5
ENSG00000130706	ADRM1	2.069579121	3.25E-5	0.001330468
ENSG00000104964	AES	2.273869416	1.15E-8	1.46E-6
ENSG00000196526	AFAP1	2.909300207	1.14E-9	1.88E-7
ENSG00000144218	AFF3	3.208224787	5.08E-24	5.91E-21
ENSG00000204305	AGER	3.009574711	2.30459E-4	0.006567389
ENSG00000204310	AGPAT1	2.008431462	1.59E-8	1.95E-6
ENSG00000168710	AHCYL1	1.910764398	1.1E-5	5.48658E-4
ENSG00000100591	AHSA1	1.776848737	1.49311E-4	0.004627686
ENSG00000186063	AIDA	1.735140707	1.55851E-4	0.004802326
ENSG00000204472	AIF1	3.179346697	1.25E-10	2.41E-8
ENSG00000042286	AIFM2	1.985838583	3.73E-6	2.24499E-4
ENSG00000110711	AIP	2.239396501	8.64E-5	0.002961546
ENSG00000129474	AJUBA	2.411791305	2.8177E-4	0.007702586
ENSG00000106992	AK1	1.97717672	4.29E-5	0.001675232
ENSG00000257173	AK6P2	-19.89956846	3.73E-5	0.001495619
ENSG00000085662	AKR1B1	4.838554462	6.56E-38	2.24E-34
ENSG00000151632	AKR1C1/AKR1C2	3.421926992	1.26E-16	6.09E-14
ENSG00000196139	AKR1C3	2.852533123	3.72E-13	1.11E-10
ENSG00000023330	ALAS1	3.381281391	1.35E-14	4.97E-12
ENSG00000170017	ALCAM	2.097525517	1.61292E-4	0.00493496
ENSG00000136010	ALDH1L2	2.468336578	9.93E-13	2.82E-10
ENSG00000111275	ALDH2	-2.164286815	9.99E-5	0.003333858
ENSG00000072210	ALDH3A2	2.297654139	2.3E-7	2.09E-5
ENSG00000159423	ALDH4A1	3.661766672	1.7E-9	2.74E-7
ENSG00000112294	ALDH5A1	2.261774889	1.13E-7	1.12E-5
ENSG00000149925	ALDOA	2.351625739	6.73E-7	5.32E-5
ENSG00000214160	ALG3	2.870508163	2.48E-6	1.58992E-4
ENSG00000132965	ALOX5AP	2.642342461	9.24E-8	9.41E-6
ENSG00000198796	ALPK2	-3.951496334	2.82E-5	0.001186526
ENSG00000136383	ALPK3	-5.764578505	2.81E-8	3.26E-6
ENSG00000162551	ALPL	6.188862792	9.74E-24	1.06E-20
ENSG00000159461	AMFR	2.175428008	1.06E-6	7.87E-5
ENSG00000126016	AMOT	-2.468686463	1.17E-6	8.54E-5
ENSG00000141552	ANAPC11	2.719955087	5.08E-9	7.04E-7
ENSG00000116194	ANGPTL1	-3.138284436	6.48E-8	6.88E-6
ENSG00000187151	ANGPTL5	-21.02274264	1.96215E-4	0.005770582
ENSG00000130173	ANGPTL8	7.230354088	1.63E-20	1.28E-17
ENSG00000166839	ANKDD1A	1.782595257	2.75389E-4	0.00756781
ENSG00000106524	ANKMY2	2.14471546	7.77E-6	4.08268E-4
ENSG00000215559	ANKRD20A11P	-7.708597868	1.39117E-4	0.004356964
ENSG00000186481	ANKRD20A5P	-6.768918407	1.08E-7	1.07E-5
ENSG00000144031	ANKRD53	-9.106093044	2.0E-6	1.34836E-4
ENSG00000156381	ANKRD9	3.828988065	2.48E-6	1.58708E-4
ENSG00000011426	ANLN	3.727918048	1.75773E-4	0.005283267
ENSG00000047617	ANO2	-1.895912744	3.12216E-4	0.008358611
ENSG00000011201	ANOS1	-4.100455065	6.0E-9	8.18E-7
ENSG00000135046	ANXA1	2.918371264	2.27E-12	5.99E-10
ENSG00000182718	ANXA2	1.670224733	2.01756E-4	0.005900829
ENSG00000164111	ANXA5	2.77703547	1.09E-13	3.57E-11
ENSG00000138279	ANXA7	1.771250392	5.49E-5	0.002049757
ENSG00000138356	AOX1	-4.012769401	7.94E-10	1.35E-7
ENSG00000100280	AP1B1	2.166412298	3.47E-6	2.11453E-4
ENSG00000042753	AP2S1	2.470035426	8.09E-7	6.22E-5
ENSG00000065000	AP3D1	1.913927058	1.03E-5	5.17086E-4
ENSG00000169188	APEX2	1.932844124	1.08491E-4	0.003566114
ENSG00000175279	APITD1/APITD1-CORT	3.235183813	1.25768E-4	0.004044988
ENSG00000084234	APLP2	1.763728093	1.8E-5	8.20087E-4
ENSG00000163382	APOA1BP	2.57633058	4.72E-8	5.2E-6
ENSG00000084674	APOB	-9.370652146	2.03E-14	7.24E-12
ENSG00000130208	APOC1	5.571105022	4.37E-17	2.35E-14
ENSG00000130203	APOE	3.423282046	2.51E-9	3.81E-7
ENSG00000100336	APOL4	-2.196868236	1.98E-5	8.87651E-4
ENSG00000178878	APOLD1	-3.291533632	9.26E-7	7.01E-5
ENSG00000142192	APP	2.506345337	7.66E-10	1.31E-7
ENSG00000198931	APRT	2.068709143	2.86057E-4	0.007798164
ENSG00000119682	AREL1	2.08565861	1.45E-8	1.81E-6
ENSG00000143761	ARF1	1.894633964	1.43173E-4	0.004460579
ENSG00000160007	ARHGAP35	1.758467421	7.23E-5	0.002566368
ENSG00000141522	ARHGDIA	2.027008603	1.32948E-4	0.004205115
ENSG00000111348	ARHGDIB	2.007881097	4.52E-5	0.00174733
ENSG00000116584	ARHGEF2	3.186465397	3.18E-23	3.37E-20
ENSG00000114790	ARHGEF26	-2.344218821	1.73946E-4	0.005241543
ENSG00000179361	ARID3B	-3.707456681	2.72E-5	0.001152434
ENSG00000213465	ARL2	2.637439217	6.49E-10	1.14E-7
ENSG00000134108	ARL8B	2.243687395	1.29E-5	6.28944E-4
ENSG00000224376	ARMC9	17.0086354	2.55E-6	1.6248E-4
ENSG00000130429	ARPC1B	2.057467483	1.91E-6	1.30026E-4
ENSG00000241553	ARPC4	2.128015261	8.33E-6	4.31342E-4
ENSG00000162704	ARPC5	1.863053255	3.00296E-4	0.008107657
ENSG00000136950	ARPC5L	2.120162597	2.38E-6	1.53581E-4
ENSG00000203993	ARRDC1-AS1	2.64511814	1.01851E-4	0.003387528
ENSG00000140450	ARRDC4	2.107122937	1.24E-5	6.07515E-4
ENSG00000100299	ARSA	2.494171654	2.29482E-4	0.006554735
ENSG00000088280	ASAP3	2.008682878	1.23E-5	6.06604E-4
ENSG00000198356	ASNA1	3.157817789	6.4E-7	5.14E-5
ENSG00000070669	ASNS	3.209297488	1.45E-12	3.96E-10
ENSG00000198363	ASPH	2.008205314	4.93E-5	0.00187506
ENSG00000130707	ASS1	1.993989903	1.50442E-4	0.004656684
ENSG00000034533	ASTE1	1.850465894	3.26628E-4	0.008671516
ENSG00000128272	ATF4	1.894701138	8.98E-7	6.84E-5
ENSG00000169136	ATF5	9.10145514	4.04E-86	1.93E-81
ENSG00000198925	ATG9A	1.948548527	1.87E-5	8.47085E-4
ENSG00000138363	ATIC	2.200251447	1.26E-6	9.15E-5
ENSG00000177556	ATOX1	2.997520431	4.79E-11	1.01E-8
ENSG00000206190	ATP10A	2.307597702	1.21E-8	1.54E-6
ENSG00000159363	ATP13A2	3.662661554	2.02E-7	1.86E-5
ENSG00000070961	ATP2B1	1.959549402	1.31142E-4	0.004165704
ENSG00000099624	ATP5D	2.099863264	1.01978E-4	0.003389403
ENSG00000159199	ATP5G1	1.950708937	3.73173E-4	0.009660226
ENSG00000169020	ATP5I	2.547806109	1.5E-8	1.86E-6
ENSG00000154723	ATP5J	1.875559561	2.2974E-4	0.006554735
ENSG00000241468	ATP5J2	2.308026039	8.98E-6	4.59515E-4
ENSG00000167283	ATP5L	1.930758168	2.03432E-4	0.005935316
ENSG00000071553	ATP6AP1	2.145024103	2.56E-7	2.27E-5
ENSG00000117410	ATP6V0B	1.964821893	5.54E-5	0.002065968
ENSG00000185883	ATP6V0C	2.368634839	2.25E-7	2.05E-5
ENSG00000114573	ATP6V1A	2.177015499	4.28E-8	4.78E-6
ENSG00000147416	ATP6V1B2	2.184320439	3.1E-7	2.71E-5
ENSG00000131100	ATP6V1E1	2.220205743	5.45E-8	5.88E-6
ENSG00000128524	ATP6V1F	2.511724914	2.28E-5	9.96864E-4
ENSG00000138085	ATRAID	2.004588761	2.23E-6	1.46949E-4
ENSG00000168488	ATXN2L	2.008310379	1.23E-6	8.97E-5
ENSG00000087152	ATXN7L3	2.024262515	6.0E-7	4.86E-5
ENSG00000175756	AURKAIP1	3.104756452	3.09E-11	6.84E-9
ENSG00000176597	B3GNT5	2.437638267	1.03E-7	1.03E-5
ENSG00000237172	B3GNT9	2.572405839	1.04E-5	5.22796E-4
ENSG00000095739	BAMBI	5.015821449	3.89E-5	0.001547556
ENSG00000175334	BANF1	2.459861641	5.01E-6	2.84488E-4
ENSG00000153064	BANK1	2.165894093	4.23E-6	2.48585E-4
ENSG00000138376	BARD1	2.562192175	1.54236E-4	0.004758707
ENSG00000075790	BCAP29	2.620410206	6.21E-16	2.7E-13
ENSG00000185825	BCAP31	2.033833664	9.32E-5	0.003156221
ENSG00000060982	BCAT1	2.961247285	6.1E-10	1.07E-7
ENSG00000103507	BCKDK	2.697874051	4.26E-5	0.00166821
ENSG00000121380	BCL2L14	-3.701954534	2.21768E-4	0.006361492
ENSG00000197580	BCO2	-2.677189209	7.06E-5	0.002515202
ENSG00000183337	BCOR	1.713037917	2.63962E-4	0.00732118
ENSG00000236824	BCYRN1	5.003519103	1.4E-25	1.76E-22
ENSG00000123095	BHLHE41	2.600995569	1.5E-16	7.09E-14
ENSG00000132840	BHMT2	1.568465933	3.10876E-4	0.008337613
ENSG00000136717	BIN1	2.014669523	7.77E-6	4.08268E-4
ENSG00000138756	BMP2K	2.014526821	7.1E-7	5.55E-5
ENSG00000164619	BMPER	4.637926544	4.43E-19	3.07E-16
ENSG00000104221	BRF2	1.705998217	1.62184E-4	0.004952716
ENSG00000164713	BRI3	2.488149773	8.33E-12	2.08E-9
ENSG00000198797	BRINP2	7.540319169	4.44E-10	7.88E-8
ENSG00000151136	BTBD11	-5.746150279	1.47666E-4	0.004582635
ENSG00000134717	BTF3L4	1.741243452	2.31301E-4	0.006586944
ENSG00000159388	BTG2	-4.831130953	4.65E-6	2.68654E-4
ENSG00000154640	BTG3	2.489777949	1.48E-6	1.04749E-4
ENSG00000136261	BZW2	1.992956723	5.1E-6	2.87433E-4
ENSG00000211450	C11orf31	2.456007282	2.66E-6	1.68049E-4
ENSG00000111412	C12orf49	2.551600971	8.31E-5	0.002864588
ENSG00000156411	C14orf2	1.919297609	6.59E-7	5.24E-5
ENSG00000167173	C15orf39	2.463774305	2.98E-6	1.8509E-4
ENSG00000205363	C15orf59	4.603039711	2.21E-7	2.02E-5
ENSG00000261652	C15orf65	5.944630006	2.89E-6	1.80224E-4
ENSG00000125319	C17orf53	-7.70773324	2.03E-5	9.02496E-4
ENSG00000108666	C17orf75	2.677620794	3.15914E-4	0.008438676
ENSG00000224877	C17orf89	3.494545504	3.97E-9	5.66E-7
ENSG00000104979	C19orf53	1.997849801	8.43E-5	0.00289966
ENSG00000174917	C19orf70	2.039938816	2.34E-6	1.52382E-4
ENSG00000197982	C1orf122	3.267201406	2.48E-9	3.79E-7
ENSG00000203709	C1orf132	-3.581503449	1.59E-8	1.95E-6
ENSG00000239887	C1orf226	-10.53731686	4.53E-8	5.02E-6
ENSG00000143612	C1orf43	2.094382978	4.17E-7	3.51E-5
ENSG00000173372	C1QA	3.446497443	2.68E-6	1.68686E-4
ENSG00000173369	C1QB	6.540180441	3.69E-17	2.08E-14
ENSG00000108561	C1QBP	1.961279191	7.03E-5	0.002506439
ENSG00000159189	C1QC	4.152844391	4.7E-13	1.39E-10
ENSG00000223953	C1QTNF5	3.282547843	1.49E-5	7.07312E-4
ENSG00000240654	C1QTNF9	-11.80035291	3.19E-5	0.001312507
ENSG00000101084	C20orf24	3.29580936	1.12E-5	5.58482E-4
ENSG00000171860	C3AR1	2.337587008	4.67E-5	0.001793449
ENSG00000243449	C4orf48	6.480904355	1.96E-9	3.06E-7
ENSG00000113583	C5orf15	2.059329391	2.05183E-4	0.00597181
ENSG00000082213	C5orf22	1.976495875	3.79E-7	3.25E-5
ENSG00000161010	C5orf45	3.41963942	2.0E-30	3.82E-27
ENSG00000039537	C6	-6.415338775	4.39E-6	2.57485E-4
ENSG00000188112	C6orf132	-5.340380257	2.19606E-4	0.006307047
ENSG00000204564	C6orf136	2.731058577	1.48997E-4	0.004620937
ENSG00000204387	C6orf48	3.448269979	6.33E-16	2.73E-13
ENSG00000112308	C6orf62	1.836681833	3.31806E-4	0.00877971
ENSG00000146540	C7orf50	4.256555106	2.9E-18	1.9E-15
ENSG00000182307	C8orf33	1.844860874	1.37669E-4	0.004325782
ENSG00000213563	C8orf82	3.270005415	2.67E-7	2.37E-5
ENSG00000148362	C9orf142	2.451367048	5.06E-5	0.001912887
ENSG00000171159	C9orf16	2.895096418	2.26E-5	9.91538E-4
ENSG00000238227	C9orf69	4.679732479	4.06E-16	1.8E-13
ENSG00000147894	C9orf72	2.477330449	3.67E-7	3.15E-5
ENSG00000157693	C9orf91	2.268729195	5.93E-7	4.81E-5
ENSG00000164879	CA3	-5.408347519	3.08217E-4	0.008288711
ENSG00000169239	CA5B	1.857974676	3.35E-7	2.9E-5
ENSG00000175161	CADM2	-6.198262604	1.31E-6	9.44E-5
ENSG00000162706	CADM3	4.459876243	1.68E-20	1.29E-17
ENSG00000225670	CADM3-AS1	2.676646548	9.74E-10	1.63E-7
ENSG00000138172	CALHM2	2.402792127	2.29E-5	9.9787E-4
ENSG00000143933	CALM1 (includes others)	2.057297052	1.57E-8	1.93E-6
ENSG00000178363	CALML3	16.09107607	5.82E-5	0.002155581
ENSG00000145349	CAMK2D	2.109899708	1.22E-6	8.89E-5
ENSG00000042493	CAPG	2.209820259	3.31E-5	0.001353181
ENSG00000162909	CAPN2	1.926968521	2.28E-6	1.49005E-4
ENSG00000077274	CAPN6	1.829831118	3.55E-5	0.001439853
ENSG00000126247	CAPNS1	2.093124808	1.59E-6	1.11227E-4
ENSG00000077549	CAPZB	1.687745317	2.5336E-4	0.007080597
ENSG00000142453	CARM1	1.937514575	1.64174E-4	0.005007102
ENSG00000110619	CARS	2.317045131	1.09E-11	2.65E-9
ENSG00000167971	CASKIN1	2.896343653	4.09E-10	7.32E-8
ENSG00000159228	CBR1	2.603208229	3.11E-6	1.91927E-4
ENSG00000122565	CBX3	1.818962395	9.96E-5	0.003329912
ENSG00000141582	CBX4	4.378306514	1.79E-10	3.4E-8
ENSG00000198937	CCDC167	3.17864534	2.06616E-4	0.005991621
ENSG00000186409	CCDC30	-2.277902969	3.34E-5	0.001362982
ENSG00000180329	CCDC43	2.767312948	1.70053E-4	0.005146971
ENSG00000186714	CCDC73	2.359760187	7.45E-5	0.002617403
ENSG00000175602	CCDC85B	3.531380552	8.19E-9	1.07E-6
ENSG00000151882	CCL28	-2.464380342	3.85687E-4	0.009946432
ENSG00000118971	CCND2	1.805491958	4.41E-5	0.001710943
ENSG00000112576	CCND3	2.152830397	1.31E-7	1.28E-5
ENSG00000118816	CCNI	2.241273273	1.82E-7	1.7E-5
ENSG00000260916	CCPG1	2.99978449	2.15E-22	2.04E-19
ENSG00000163823	CCR1	2.912978286	1.54E-5	7.24977E-4
ENSG00000107771	CCSER2	1.764606148	5.26E-5	0.001978404
ENSG00000166226	CCT2	1.701767053	3.69796E-4	0.009593616
ENSG00000150753	CCT5	1.927384698	6.77E-6	3.62348E-4
ENSG00000170458	CD14	5.823569097	1.22E-25	1.58E-22
ENSG00000177697	CD151	1.757428424	8.35E-6	4.32237E-4
ENSG00000117281	CD160	-3.562349185	4.01E-5	0.001584793
ENSG00000177675	CD163L1	2.004520979	3.62912E-4	0.009456114
ENSG00000116824	CD2	5.810627842	1.12729E-4	0.003685185
ENSG00000090659	CD209	2.31926846	3.76E-6	2.25508E-4
ENSG00000178562	CD28	3.704172278	3.17E-9	4.66E-7
ENSG00000010610	CD4	2.350558907	3.51E-7	3.02E-5
ENSG00000169442	CD52	4.284152798	2.37E-6	1.53463E-4
ENSG00000143119	CD53	2.48037633	4.07E-5	0.001598921
ENSG00000135404	CD63	1.781336674	3.51E-5	0.001425683
ENSG00000129226	CD68	2.745790053	3.9E-11	8.35E-9
ENSG00000019582	CD74	2.360624111	1.83E-6	1.26211E-4
ENSG00000112149	CD83	3.237024478	3.7E-6	2.23312E-4
ENSG00000081377	CDC14B	1.886428053	2.74736E-4	0.007554209
ENSG00000128283	CDC42EP1	2.882167531	5.92E-9	8.11E-7
ENSG00000145526	CDH18	-2.958996099	5.01E-5	0.001896475
ENSG00000101542	CDH20	-4.466028744	2.66846E-4	0.007384021
ENSG00000102225	CDK16	1.918991774	1.3116E-4	0.004165704
ENSG00000153879	CEBPG	2.086015669	1.48E-7	1.41E-5
ENSG00000093072	CECR1	2.274760809	4.4E-8	4.91E-6
ENSG00000143418	CERS2	1.787960779	2.95716E-4	0.008015711
ENSG00000172292	CERS6	2.229737147	7.84E-6	4.11241E-4
ENSG00000227617	CERS6-AS1	1.972260302	4.43E-6	2.59459E-4
ENSG00000198848	CES1	5.504765251	6.98E-18	4.44E-15
ENSG00000172831	CES2	2.74051402	4.98E-11	1.05E-8
ENSG00000000971	CFH	2.075453458	6.04E-5	0.002220387
ENSG00000172757	CFL1	2.033378285	4.63E-5	0.001783198
ENSG00000165410	CFL2	2.091694787	2.23E-5	9.80787E-4
ENSG00000128965	CHAC1	7.77418176	5.93E-9	8.11E-7
ENSG00000250479	CHCHD10	4.320760781	4.28E-14	1.46E-11
ENSG00000106153	CHCHD2	1.980940667	3.93E-5	0.001555082
ENSG00000163528	CHCHD4	2.390381709	6.94E-5	0.002480485
ENSG00000131778	CHD1L	2.070760701	2.8E-5	0.001178879
ENSG00000177830	CHID1	1.840332269	1.87E-5	8.47691E-4
ENSG00000131165	CHMP1A	2.207291942	2.83E-5	0.001187915
ENSG00000171310	CHST11	1.861235959	2.03865E-4	0.005944312
ENSG00000182022	CHST15	1.855175754	2.97948E-4	0.008067054
ENSG00000175040	CHST2	5.230204988	9.45E-17	4.7E-14
ENSG00000005194	CIAPIN1	2.577820964	1.16E-7	1.14E-5
ENSG00000176194	CIDEA	-11.11771879	2.46E-13	7.67E-11
ENSG00000186162	CIDECP	1.836318896	1.69259E-4	0.00512956
ENSG00000122873	CISD1	2.616570148	1.4E-5	6.74731E-4
ENSG00000145354	CISD2	2.392467635	1.44E-5	6.87637E-4
ENSG00000125931	CITED1	11.07379444	2.2E-15	9.05E-13
ENSG00000148337	CIZ1	2.047978399	1.94E-5	8.73461E-4
ENSG00000136108	CKAP2	2.534159133	2.48E-5	0.001064229
ENSG00000136026	CKAP4	1.995708867	4.96E-6	2.8338E-4
ENSG00000109572	CLCN3	2.588339627	5.03E-11	1.05E-8
ENSG00000073464	CLCN4	2.560805214	2.02E-6	1.35759E-4
ENSG00000103249	CLCN7	2.356539334	3.58E-6	2.16562E-4
ENSG00000163347	CLDN1	3.772674895	2.11E-6	1.40746E-4
ENSG00000153132	CLGN	13.49195303	1.74E-43	7.54E-40
ENSG00000130779	CLIP1	1.7123499	1.58E-5	7.4093E-4
ENSG00000104853	CLPTM1	2.131616257	9.89E-8	1.0E-5
ENSG00000158258	CLSTN2	-6.392991166	4.34E-12	1.12E-9
ENSG00000250433	CLSTN2-AS1	-53.45218954	1.60234E-4	0.00491519
ENSG00000175416	CLTB	2.056734954	4.72E-5	0.001809638
ENSG00000092009	CMA1	4.219145121	1.33E-7	1.29E-5
ENSG00000103121	CMC2	2.352048021	2.32E-7	2.1E-5
ENSG00000169714	CNBP	1.756422542	2.82067E-4	0.007702586
ENSG00000133313	CNDP2	1.837536606	1.83E-5	8.34514E-4
ENSG00000182973	CNOT10	2.057076191	1.63E-9	2.64E-7
ENSG00000137161	CNPY3	2.178083811	3.82E-6	2.27637E-4
ENSG00000119865	CNRIP1	2.014166745	8.48E-6	4.37524E-4
ENSG00000108797	CNTNAP1	-2.079367554	3.21826E-4	0.008577426
ENSG00000152910	CNTNAP4	-6.918960064	3.48E-6	2.11453E-4
ENSG00000183978	COA3	1.943631629	3.70758E-4	0.009608126
ENSG00000068120	COASY	2.01501539	4.95E-5	0.001881089
ENSG00000204291	COL15A1	2.077274369	2.6719E-4	0.007384992
ENSG00000084636	COL16A1	2.926849186	2.84E-14	9.98E-12
ENSG00000204262	COL5A2	2.038318938	1.93E-5	8.72014E-4
ENSG00000080573	COL5A3	2.160599675	1.35E-6	9.7E-5
ENSG00000206384	COL6A6	-2.951696382	1.08E-5	5.38956E-4
ENSG00000144810	COL8A1	-3.147995544	4.72E-7	3.95E-5
ENSG00000130309	COLGALT1	2.404024788	7.82E-10	1.33E-7
ENSG00000173163	COMMD1	2.055671377	6.97E-6	3.7085E-4
ENSG00000114744	COMMD2	1.650732697	2.88986E-4	0.007864522
ENSG00000110442	COMMD9	1.757251634	6.8E-5	0.002440534
ENSG00000093010	COMT	2.977860771	1.49E-13	4.82E-11
ENSG00000141030	COPS3	2.2507839	7.02E-7	5.5E-5
ENSG00000138663	COPS4	1.998870515	2.21E-5	9.72407E-4
ENSG00000111652	COPS7A	2.171780781	7.53E-7	5.85E-5
ENSG00000198612	COPS8	2.035028705	3.52956E-4	0.009231956
ENSG00000178449	COX14	1.807636702	1.21722E-4	0.003933104
ENSG00000138495	COX17	2.819652691	5.72E-8	6.13E-6
ENSG00000115944	COX7A2L	2.119112333	1.68E-5	7.8002E-4
ENSG00000131174	COX7B	1.825316566	1.31179E-4	0.004165704
ENSG00000163751	CPA3	4.811853468	1.53E-20	1.22E-17
ENSG00000160111	CPAMD8	-2.976488018	1.35E-6	9.69E-5
ENSG00000214575	CPEB1	3.018882383	4.2E-6	2.47427E-4
ENSG00000113742	CPEB4	2.169362017	3.05E-6	1.8848E-4
ENSG00000135678	CPM	-3.435400712	1.6E-7	1.51E-5
ENSG00000196353	CPNE4	-5.57917431	1.63E-5	7.59052E-4
ENSG00000106066	CPVL	2.015572336	1.9172E-4	0.005669822
ENSG00000095321	CRAT	1.925785794	5.16E-6	2.89484E-4
ENSG00000143162	CREG1	2.085475973	5.64E-6	3.12325E-4
ENSG00000103196	CRISPLD2	-2.226872006	7.55E-5	0.002638405
ENSG00000109846	CRYAB	1.731868629	9.98E-5	0.003333085
ENSG00000182578	CSF1R	2.859793839	7.4E-10	1.28E-7
ENSG00000113712	CSNK1A1	1.694113559	1.59874E-4	0.004910434
ENSG00000144655	CSRNP1	-4.02364691	4.46E-6	2.60467E-4
ENSG00000110925	CSRNP2	2.138930882	4.19E-8	4.71E-6
ENSG00000175183	CSRP2	-2.21603583	3.37E-5	0.001373613
ENSG00000149474	CSRP2BP	1.925321884	6.09E-5	0.002234633
ENSG00000175315	CST6	18.63190946	7.45E-6	3.94446E-4
ENSG00000121552	CSTA	4.751213591	3.64E-19	2.55E-16
ENSG00000160213	CSTB	4.141120918	2.95E-24	3.55E-21
ENSG00000176102	CSTF3	1.856218279	2.61973E-4	0.007278709
ENSG00000159692	CTBP1	1.864477779	8.94E-5	0.003049391
ENSG00000175826	CTDNEP1	1.947744593	1.03E-6	7.67E-5
ENSG00000044115	CTNNA1	1.720636772	2.49142E-4	0.00698314
ENSG00000171793	CTPS1	2.587359749	4.92E-5	0.00187506
ENSG00000064601	CTSA	2.235865879	5.51E-7	4.53E-5
ENSG00000164733	CTSB	2.397721797	1.71E-11	4.05E-9
ENSG00000117984	CTSD	3.526028674	4.17E-17	2.26E-14
ENSG00000100448	CTSG	3.276474769	2.36E-6	1.5284E-4
ENSG00000163131	CTSS	1.987687613	5.06E-6	2.86152E-4
ENSG00000107611	CUBN	2.005623435	6.29E-6	3.42382E-4
ENSG00000112514	CUTA	2.088765089	9.35E-5	0.0031619
ENSG00000169245	CXCL10	8.059106378	7.66E-5	0.002671957
ENSG00000145824	CXCL14	1.904819338	2.06E-5	9.1509E-4
ENSG00000161921	CXCL16	2.560268206	4.33E-10	7.71E-8
ENSG00000138755	CXCL9	5.451997188	9.12E-11	1.82E-8
ENSG00000171604	CXXC5	2.137005699	1.04E-5	5.2447E-4
ENSG00000165168	CYBB	2.531528781	8.67E-8	8.89E-6
ENSG00000172115	CYCS	2.343191123	6.73E-8	7.13E-6
ENSG00000161544	CYGB	3.456760022	3.06E-11	6.8E-9
ENSG00000106258	CYP3A5	-1.950413653	1.87E-5	8.47691E-4
ENSG00000187048	CYP4A11	-3.059400678	8.38E-5	0.002885398
ENSG00000142973	CYP4B1	-7.122460249	1.41E-15	5.95E-13
ENSG00000171903	CYP4F11	4.053265216	7.24E-8	7.58E-6
ENSG00000154198	CYP4Z2P	-5.983502312	1.89505E-4	0.005618213
ENSG00000142871	CYR61	-3.872739163	1.71E-5	7.89266E-4
ENSG00000120306	CYSTM1	2.47138987	3.34E-9	4.88E-7
ENSG00000153071	DAB2	1.972372507	6.37E-6	3.45668E-4
ENSG00000129562	DAD1	2.145568418	2.54E-6	1.61913E-4
ENSG00000226950	DANCR	2.093499291	1.93023E-4	0.00570128
ENSG00000112977	DAP	2.011033588	1.79422E-4	0.005365917
ENSG00000035664	DAPK2	-2.360371487	1.95E-7	1.81E-5
ENSG00000198876	DCAF12	1.915761616	6.75E-5	0.002431981
ENSG00000170390	DCLK2	3.712565096	8.71E-13	2.51E-10
ENSG00000179958	DCTPP1	2.53498355	1.44E-5	6.86267E-4
ENSG00000137692	DCUN1D5	2.622815426	1.83613E-4	0.005470699
ENSG00000077279	DCX	-3.092454057	3.36819E-4	0.00888283
ENSG00000213722	DDAH2	2.075658781	7.98E-6	4.16564E-4
ENSG00000175197	DDIT3	6.612481067	5.91E-30	1.08E-26
ENSG00000064703	DDX20	2.34757333	2.09E-6	1.39597E-4
ENSG00000105671	DDX49	2.724454561	2.71E-6	1.70055E-4
ENSG00000177030	DEAF1	2.939427887	4.14E-9	5.89E-7
ENSG00000186458	DEFB132	-8.801392042	3.47E-6	2.11453E-4
ENSG00000143753	DEGS1	2.213622876	1.1E-9	1.82E-7
ENSG00000205744	DENND1C	3.397596453	3.86E-5	0.001537472
ENSG00000198837	DENND4B	1.718271156	9.97E-5	0.003332967
ENSG00000136986	DERL1	2.042386515	1.98E-6	1.33915E-4
ENSG00000062282	DGAT2	2.845578557	6.6E-6	3.55595E-4
ENSG00000128185	DGCR6L	4.236564839	3.16E-5	0.001301968
ENSG00000145214	DGKQ	3.727243174	1.62E-9	2.62E-7
ENSG00000109016	DHRS7B	1.827760906	2.37109E-4	0.006728799
ENSG00000169084	DHRSX	2.162826619	2.89E-6	1.80224E-4
ENSG00000089876	DHX32	1.892555553	1.08584E-4	0.003566114
ENSG00000067596	DHX8	1.775924637	2.9784E-4	0.008067054
ENSG00000066084	DIP2B	1.868039035	6.56E-6	3.53769E-4
ENSG00000176490	DIRAS1	3.27538826	1.75591E-4	0.005281122
ENSG00000080845	DLGAP4	3.935085984	8.04E-19	5.33E-16
ENSG00000198947	DMD	-2.399684019	5.93E-5	0.002193576
ENSG00000158856	DMTN	1.841673689	2.37377E-4	0.006732398
ENSG00000104093	DMXL2	1.618531355	2.00885E-4	0.005884087
ENSG00000250091	DNAH10OS	3.709410953	5.49E-7	4.53E-5
ENSG00000090520	DNAJB11	1.71375909	3.40638E-4	0.008958814
ENSG00000136770	DNAJC1	2.335216463	6.22E-5	0.00227216
ENSG00000110011	DNAJC4	2.027301405	1.44107E-4	0.004486774
ENSG00000100246	DNAL4	3.242808763	1.29763E-4	0.004137271
ENSG00000163687	DNASE1L3	2.193234404	1.85E-5	8.40636E-4
ENSG00000112667	DNPH1	3.13999758	4.99E-6	2.84322E-4
ENSG00000101134	DOK5	5.59321778	3.39E-17	1.95E-14
ENSG00000132768	DPH2	3.430695614	1.97E-9	3.07E-7
ENSG00000136908	DPM2	2.697785099	5.15E-6	2.89484E-4
ENSG00000179085	DPM3	3.328284808	5.2E-8	5.62E-6
ENSG00000254986	DPP3	2.338691427	1.23E-5	6.06376E-4
ENSG00000143196	DPT	-1.985068053	1.00028E-4	0.003333858
ENSG00000235436	DPY19L2P4	-2.072630802	2.56317E-4	0.007145101
ENSG00000134760	DSG1	5.990203511	5.11E-6	2.87703E-4
ENSG00000168393	DTYMK	2.17706121	2.34E-5	0.001014588
ENSG00000143507	DUSP10	3.707899606	5.61E-7	4.59E-5
ENSG00000120875	DUSP4	2.166968629	1.63E-5	7.59052E-4
ENSG00000139318	DUSP6	2.123241845	5.35E-7	4.43E-5
ENSG00000107404	DVL1	2.06462562	3.03E-5	0.001256786
ENSG00000161202	DVL3	1.889297726	1.56E-5	7.33066E-4
ENSG00000141627	DYM	1.679725253	3.22668E-4	0.008595062
ENSG00000088986	DYNLL1	1.885933026	8.57E-5	0.002943758
ENSG00000125971	DYNLRB1	1.992767486	1.4552E-4	0.004524865
ENSG00000146425	DYNLT1	2.385591968	2.96E-9	4.37E-7
ENSG00000121310	ECHDC2	-2.543440917	3.9E-7	3.32E-5
ENSG00000134109	EDEM1	2.915500176	4.51E-13	1.34E-10
ENSG00000107223	EDF1	2.188949466	5.5E-7	4.53E-5
ENSG00000078401	EDN1	-11.80881074	3.51E-5	0.001425683
ENSG00000114942	EEF1B2	1.848775065	1.03539E-4	0.003432055
ENSG00000104529	EEF1D	1.652805882	1.90182E-4	0.005634785
ENSG00000172638	EFEMP2	1.75734592	2.93547E-4	0.007975034
ENSG00000132294	EFR3A	1.920143473	6.27E-6	3.41765E-4
ENSG00000100842	EFS	2.017218115	6.69E-5	0.002413711
ENSG00000120738	EGR1	-3.965562649	2.73E-5	0.001152888
ENSG00000086232	EIF2AK1	1.706662145	2.52311E-4	0.007059548
ENSG00000125977	EIF2S2	2.383871345	1.86E-9	2.94E-7
ENSG00000106263	EIF3B	1.73605836	2.04478E-4	0.005958551
ENSG00000100353	EIF3D	1.825897993	6.3E-6	3.42676E-4
ENSG00000130811	EIF3G	1.862120237	3.8E-5	0.001521454
ENSG00000084623	EIF3I	1.902339875	2.84E-5	0.001191308
ENSG00000132507	EIF5A	1.85287208	1.67866E-4	0.005100534
ENSG00000062598	ELMO2	1.744969522	9.71E-5	0.003264853
ENSG00000170291	ELP5	2.686519715	6.71E-7	5.31E-5
ENSG00000127774	EMC6	3.343051717	1.30323E-4	0.004152355
ENSG00000134153	EMC7	2.025299105	1.65E-5	7.66445E-4
ENSG00000102119	EMD	2.066650859	6.08E-5	0.002232327
ENSG00000126749	EMG1	2.100191201	9.05E-5	0.003082489
ENSG00000143924	EML4	2.103402334	2.55E-6	1.62233E-4
ENSG00000154380	ENAH	2.075963014	1.87E-7	1.75E-5
ENSG00000106991	ENG	1.988614577	2.77912E-4	0.00762397
ENSG00000074800	ENO1	2.918061817	5.05E-14	1.7E-11
ENSG00000145293	ENOPH1	2.666001575	1.15E-5	5.66878E-4
ENSG00000187097	ENTPD5	2.574405392	1.04E-10	2.05E-8
ENSG00000082397	EPB41L3	2.86374504	9.59E-14	3.18E-11
ENSG00000095203	EPB41L4B	-2.606764481	3.23267E-4	0.008606231
ENSG00000182580	EPHB3	5.859891063	2.15E-8	2.57E-6
ENSG00000143819	EPHX1	3.055369904	8.93E-11	1.78E-8
ENSG00000136628	EPRS	2.356075283	5.76E-11	1.19E-8
ENSG00000164308	ERAP2	2.904765443	1.79E-9	2.84E-7
ENSG00000204334	ERICH2	14.18737512	2.64E-17	1.55E-14
ENSG00000178607	ERN1	3.149089542	3.84E-9	5.53E-7
ENSG00000089248	ERP29	1.77425778	3.12E-5	0.00129157
ENSG00000213462	ERV3-1	3.3641372	3.3E-15	1.32E-12
ENSG00000140009	ESR2	-3.102812021	7.39E-8	7.72E-6
ENSG00000244405	ETV5	3.857467731	3.42E-11	7.42E-9
ENSG00000142694	EVA1B	4.117415631	1.97E-6	1.33543E-4
ENSG00000185862	EVI2B	2.37645202	3.78E-6	2.25568E-4
ENSG00000064655	EYA2	2.797142038	2.61E-6	1.65607E-4
ENSG00000124491	F13A1	3.803696512	1.12E-17	6.97E-15
ENSG00000127533	F2RL3	-2.852611855	1.51E-5	7.14265E-4
ENSG00000221968	FADS3	3.583545275	2.02E-19	1.46E-16
ENSG00000183688	FAM101B	1.804238028	3.10414E-4	0.008333725
ENSG00000188938	FAM120AOS	1.968324845	2.48E-5	0.001063798
ENSG00000203950	FAM127B	2.049154357	6.65E-6	3.56642E-4
ENSG00000135842	FAM129A	3.844840678	2.97E-24	3.55E-21
ENSG00000144567	FAM134A	1.823449234	1.4E-5	6.72989E-4
ENSG00000156050	FAM161B	1.792739785	1.38547E-4	0.004347664
ENSG00000114023	FAM162A	1.8964471	2.40459E-4	0.006783566
ENSG00000161682	FAM171A2	3.593242011	1.01E-5	5.09238E-4
ENSG00000144369	FAM171B	4.639157957	1.04E-20	8.4E-18
ENSG00000173065	FAM222B	1.739850711	2.44E-5	0.001053787
ENSG00000167930	FAM234A	2.379132929	4.17E-7	3.51E-5
ENSG00000119979	FAM45A	2.194438227	2.16E-10	4.05E-8
ENSG00000189157	FAM47E	-2.136071931	4.07E-5	0.001598921
ENSG00000197872	FAM49A	2.406392637	3.14E-7	2.74E-5
ENSG00000176973	FAM89B	2.693877914	2.02759E-4	0.005919298
ENSG00000176853	FAM91A1	1.7904646	2.87936E-4	0.007840417
ENSG00000166595	FAM96B	2.336596134	3.64619E-4	0.009486156
ENSG00000112039	FANCE	3.857641592	1.38E-8	1.73E-6
ENSG00000145982	FARS2	2.73734373	1.57538E-4	0.004851187
ENSG00000179115	FARSA	2.942142563	1.72E-7	1.62E-5
ENSG00000116120	FARSB	2.179177253	2.32E-5	0.001009163
ENSG00000026103	FAS	2.5516816	3.83E-5	0.001530421
ENSG00000165323	FAT3	-2.540601319	3.4E-6	2.08733E-4
ENSG00000149806	FAU	1.974412119	2.47E-5	0.001061176
ENSG00000105202	FBL	1.750836901	2.39434E-4	0.006772967
ENSG00000171823	FBXL14	3.20102217	3.5E-7	3.02E-5
ENSG00000147912	FBXO10	2.580028503	2.97E-7	2.6E-5
ENSG00000143756	FBXO28	2.349158568	6.12E-6	3.34536E-4
ENSG00000159069	FBXW5	2.250415395	3.01E-5	0.001250106
ENSG00000179639	FCER1A	4.128515636	1.87E-6	1.28199E-4
ENSG00000158869	FCER1G	3.651752908	1.25E-12	3.48E-10
ENSG00000143226	FCGR2A	2.55951169	1.49E-8	1.86E-6
ENSG00000203747	FCGR3A/FCGR3B	2.531348121	1.91156E-4	0.005656637
ENSG00000104870	FCGRT	2.25183932	1.17E-6	8.54E-5
ENSG00000267673	FDX1L	4.274806941	2.19E-5	9.6552E-4
ENSG00000066926	FECH	1.925664414	7.48E-5	0.002621583
ENSG00000113578	FGF1	4.419014498	7.38E-22	6.41E-19
ENSG00000138685	FGF2	2.22810006	5.69E-6	3.1405E-4
ENSG00000066468	FGFR2	1.92730471	5.95E-5	0.002198385
ENSG00000022267	FHL1	-2.792689064	1.72E-7	1.62E-5
ENSG00000198855	FICD	2.987292321	2.23E-6	1.46949E-4
ENSG00000214253	FIS1	2.014476685	4.46E-6	2.60467E-4
ENSG00000088832	FKBP1A	1.768776556	9.8E-5	0.00328798
ENSG00000173486	FKBP2	2.176876551	3.14E-8	3.61E-6
ENSG00000004478	FKBP4	2.098216911	4.89E-6	2.80227E-4
ENSG00000096060	FKBP5	-3.844414809	1.63E-5	7.59052E-4
ENSG00000196924	FLNA	2.044237275	4.97E-6	2.8338E-4
ENSG00000128591	FLNC	5.228902135	8.32E-29	1.47E-25
ENSG00000137312	FLOT1	1.907368341	1.5E-5	7.08851E-4
ENSG00000126500	FLRT1	5.669300889	4.21E-8	4.72E-6
ENSG00000155816	FMN2	-8.261580396	1.8726E-4	0.005558551
ENSG00000010932	FMO1	2.785819902	5.39E-7	4.46E-5
ENSG00000141560	FN3KRP	2.036685023	1.69E-5	7.83415E-4
ENSG00000165457	FOLR2	3.293369215	3.43E-8	3.92E-6
ENSG00000170345	FOS	-4.893538455	1.05E-6	7.83E-5
ENSG00000125740	FOSB	-12.95127599	1.2E-9	1.96E-7
ENSG00000100350	FOXRED2	1.902179553	3.33492E-4	0.008809694
ENSG00000187474	FPR3	2.936186885	2.17E-5	9.54995E-4
ENSG00000138759	FRAS1	-4.321470889	7.2E-5	0.002556148
ENSG00000153303	FRMD1	-5.007350715	2.8E-5	0.001178957
ENSG00000137218	FRS3	-4.49967516	2.61E-6	1.65607E-4
ENSG00000167996	FTH1	4.437927054	1.67E-27	2.57E-24
ENSG00000087086	FTL	5.238961512	3.06E-35	8.59E-32
ENSG00000179163	FUCA1	2.225111181	3.2E-5	0.001316047
ENSG00000001036	FUCA2	2.028196481	6.02E-5	0.002216405
ENSG00000082074	FYB	2.243912541	2.45E-6	1.57504E-4
ENSG00000122068	FYTTD1	1.781438498	3.27696E-4	0.008695036
ENSG00000123689	G0S2	3.872444455	2.51E-9	3.81E-7
ENSG00000138757	G3BP2	1.695221665	2.41804E-4	0.006813451
ENSG00000160211	G6PD	2.441329381	3.12E-5	0.00129157
ENSG00000171298	GAA	2.242354084	5.94E-6	3.26548E-4
ENSG00000033327	GAB2	2.687147517	7.3E-13	2.14E-10
ENSG00000170296	GABARAP	2.1548799	1.14E-5	5.64956E-4
ENSG00000099860	GADD45B	-5.366888304	1.33E-7	1.29E-5
ENSG00000144278	GALNT13	2.194624973	8.49E-6	4.37635E-4
ENSG00000131386	GALNT15	-2.307956477	2.0263E-4	0.005919147
ENSG00000257594	GALNT4	-5.195106661	2.35E-5	0.001018241
ENSG00000089597	GANAB	1.861251682	8.74E-5	0.002990242
ENSG00000111640	GAPDH	3.385729565	1.6E-13	5.13E-11
ENSG00000106105	GARS	5.946916474	6.39E-58	6.11E-54
ENSG00000234741	GAS5	1.686150985	1.98652E-4	0.005824313
ENSG00000167491	GATAD2A	1.986947937	1.49E-6	1.04777E-4
ENSG00000177628	GBA	2.522786885	2.97E-9	4.38E-7
ENSG00000114480	GBE1	2.510154319	9.11E-8	9.3E-6
ENSG00000117228	GBP1	1.812068547	1.75511E-4	0.005281122
ENSG00000023909	GCLM	2.48868023	2.64E-13	8.12E-11
ENSG00000006007	GDE1	2.66824531	9.36E-12	2.3E-9
ENSG00000130513	GDF15	13.73933885	6.8E-24	7.55E-21
ENSG00000198380	GFPT1	1.934713799	5.86E-7	4.77E-5
ENSG00000204136	GGTA1P	2.345364704	6.79E-5	0.002440534
ENSG00000165678	GHITM	2.089406736	1.14055E-4	0.00371835
ENSG00000010310	GIPR	-3.062800761	4.04E-5	0.001592958
ENSG00000108262	GIT1	2.03662103	1.38E-5	6.66671E-4
ENSG00000165474	GJB2	8.056878782	8.6E-11	1.73E-8
ENSG00000121742	GJB6	15.14571455	1.66303E-4	0.005059102
ENSG00000170266	GLB1	2.083012919	1.57E-6	1.09732E-4
ENSG00000139278	GLIPR1	2.383861062	2.25E-6	1.47773E-4
ENSG00000126603	GLIS2	4.573361935	3.61E-17	2.05E-14
ENSG00000124767	GLO1	2.192013865	4.71E-6	2.71342E-4
ENSG00000167699	GLOD4	1.586504658	3.87781E-4	0.009982327
ENSG00000135821	GLUL	-5.202378123	3.9E-8	4.41E-6
ENSG00000149124	GLYAT	-5.125497521	6.85E-9	9.21E-7
ENSG00000196743	GM2A	2.684292166	1.51E-12	4.11E-10
ENSG00000146535	GNA12	1.963153392	6.43E-6	3.48846E-4
ENSG00000078369	GNB1	1.913541284	4.91E-5	0.001872974
ENSG00000186469	GNG2	2.150716047	1.9E-6	1.29749E-4
ENSG00000174021	GNG5	2.434326512	1.42E-6	1.00956E-4
ENSG00000163938	GNL3	2.639798721	2.66E-12	6.95E-10
ENSG00000120053	GOT1	3.686683268	1.18E-11	2.83E-9
ENSG00000197858	GPAA1	3.133746057	1.69E-10	3.22E-8
ENSG00000063660	GPC1	6.44872234	2.45E-28	4.04E-25
ENSG00000076716	GPC4	3.304817894	1.79E-9	2.84E-7
ENSG00000173264	GPR137	2.498896524	3.85E-5	0.001536345
ENSG00000154478	GPR26	-28.42350964	1.27842E-4	0.004095145
ENSG00000132522	GPS2	1.71017734	3.24542E-4	0.008625744
ENSG00000141449	GREB1L	-5.012207208	5.51E-9	7.6E-7
ENSG00000030582	GRN	1.992043298	1.27E-5	6.2215E-4
ENSG00000073605	GSDMB	-2.662711571	1.98E-5	8.87651E-4
ENSG00000103342	GSPT1	1.805094109	7.34E-5	0.002589066
ENSG00000100983	GSS	2.143051943	4.91E-6	2.8087E-4
ENSG00000084207	GSTP1	2.267478199	1.25E-5	6.13321E-4
ENSG00000172432	GTPBP2	2.42041722	4.81E-7	4.01E-5
ENSG00000151806	GUF1	2.15573413	7.93E-6	4.15035E-4
ENSG00000143774	GUK1	2.090202246	2.63E-6	1.66096E-4
ENSG00000144366	GULP1	2.091160606	7.29E-7	5.68E-5
ENSG00000172986	GXYLT2	2.246288082	3.53E-5	0.001432986
ENSG00000104812	GYS1	2.519411867	5.68E-8	6.09E-6
ENSG00000111713	GYS2	-13.61096769	5.63E-5	0.002094645
ENSG00000125812	GZF1	2.036140743	2.65E-5	0.001126261
ENSG00000189060	H1F0	2.100990508	7.72E-8	8.01E-6
ENSG00000164032	H2AFZ	2.787816528	8.26E-11	1.66E-8
ENSG00000130956	HABP4	1.935345287	3.19E-5	0.001312507
ENSG00000138029	HADHB	1.970798833	1.07E-5	5.36952E-4
ENSG00000063854	HAGH	1.817937441	2.43766E-4	0.00684863
ENSG00000143575	HAX1	2.397754118	8.58E-8	8.83E-6
ENSG00000182782	HCAR2	-3.594629488	2.17223E-4	0.006249865
ENSG00000231074	HCG18	1.832828775	3.84386E-4	0.009918249
ENSG00000143321	HDGF	1.969341653	4.39E-5	0.001707682
ENSG00000213614	HEXA	1.887583147	1.45E-6	1.02137E-4
ENSG00000100644	HIF1A	2.014764933	2.19E-8	2.6E-6
ENSG00000146066	HIGD2A	2.020513352	6.25E-5	0.002281149
ENSG00000169567	HINT1	2.961813642	1.42E-12	3.88E-10
ENSG00000184357	HIST1H1B	12.65892871	7.42E-5	0.002608687
ENSG00000187837	HIST1H1C	2.382564984	3.14E-5	0.001295668
ENSG00000168298	HIST1H1E	2.664408064	3.5E-8	3.99E-6
ENSG00000180573	HIST1H2AC	2.854550525	1.76E-5	8.0679E-4
ENSG00000180596	HIST1H2BC	2.112365732	3.49712E-4	0.009162135
ENSG00000197903	HIST1H2BK	2.670841572	3.81E-6	2.27463E-4
ENSG00000197153	HIST1H3J	14.35666171	2.05E-9	3.18E-7
ENSG00000197061	HIST1H4C	3.174036042	7.17E-5	0.002550475
ENSG00000158406	HIST1H4H	3.158711962	1.2857E-4	0.004107439
ENSG00000184270	HIST2H2AB	4.525034898	4.85E-5	0.001853577
ENSG00000184260	HIST2H2AC	2.202959861	2.22607E-4	0.00638172
ENSG00000156515	HK1	2.024700006	4.42E-7	3.7E-5
ENSG00000206503	HLA-A	2.54049044	1.67E-6	1.15916E-4
ENSG00000196735	HLA-DQA1	3.798662407	1.99E-6	1.3465E-4
ENSG00000179344	HLA-DQB1	3.39546037	1.39652E-4	0.004370848
ENSG00000204287	HLA-DRA	2.737440404	5.57E-11	1.16E-8
ENSG00000229391	HLA-DRB6	2.937885823	5.66E-6	3.12827E-4
ENSG00000204632	HLA-G	3.545471691	6.02E-7	4.87E-5
ENSG00000159267	HLCS	2.945627047	4.61E-17	2.44E-14
ENSG00000071794	HLTF	1.893450497	3.38214E-4	0.008914697
ENSG00000256269	HMBS	3.12928482	2.92507E-4	0.007951291
ENSG00000137309	HMGA1	3.57066575	1.65E-12	4.46E-10
ENSG00000112972	HMGCS1	3.279134838	4.14E-17	2.26E-14
ENSG00000100292	HMOX1	3.09595709	4.79E-6	2.74899E-4
ENSG00000177733	HNRNPA0	2.243865531	9.83E-7	7.36E-5
ENSG00000255141	HNRNPA1P76	-6.146371519	1.31637E-4	0.004171939
ENSG00000197451	HNRNPAB	1.918303555	1.77401E-4	0.00531213
ENSG00000165119	HNRNPK	1.811996647	1.86717E-4	0.00554935
ENSG00000254369	HOXA-AS3	-7.314102125	4.13E-5	0.001620962
ENSG00000253293	HOXA10	-4.833067868	1.34837E-4	0.004253607
ENSG00000122592	HOXA7	-5.129488039	1.61E-8	1.96E-6
ENSG00000233101	HOXB-AS3	2.544133167	3.59E-5	0.001450151
ENSG00000120075	HOXB5	3.809730106	4.9E-7	4.08E-5
ENSG00000115756	HPCAL1	2.10852719	7.34E-5	0.002589066
ENSG00000107521	HPS1	1.912333529	2.16134E-4	0.006229801
ENSG00000174775	HRAS	2.151951214	2.87386E-4	0.007829915
ENSG00000153936	HS2ST1	2.15822231	4.59E-5	0.001769348
ENSG00000136720	HS6ST1	2.9325603	1.12E-9	1.86E-7
ENSG00000102878	HSF4	2.596681929	2.81E-7	2.48E-5
ENSG00000155304	HSPA13	2.22004509	2.03E-5	9.02496E-4
ENSG00000126803	HSPA2	2.682569286	2.03E-5	9.02496E-4
ENSG00000170606	HSPA4	2.110372834	3.81E-8	4.32E-6
ENSG00000044574	HSPA5	6.109999081	2.61E-48	1.39E-44
ENSG00000225217	HSPA7	2.903881931	3.70035E-4	0.009594588
ENSG00000109971	HSPA8	2.351496729	1.8E-8	2.17E-6
ENSG00000113013	HSPA9	3.818963113	5.6E-26	7.87E-23
ENSG00000106211	HSPB1	1.777545597	3.56405E-4	0.009311947
ENSG00000152137	HSPB8	2.200680462	2.52E-6	1.61213E-4
ENSG00000120694	HSPH1	2.170124504	1.32E-6	9.5E-5
ENSG00000166033	HTRA1	1.787799416	4.43E-5	0.001717461
ENSG00000149428	HYOU1	2.105913639	1.89E-6	1.29309E-4
ENSG00000196305	IARS	3.210697413	9.56E-17	4.71E-14
ENSG00000116237	ICMT	1.808855855	5.12E-5	0.001932844
ENSG00000167862	ICT1	2.100532086	6.63E-6	3.56343E-4
ENSG00000119632	IFI27L2	2.854875481	2.38E-6	1.53581E-4
ENSG00000216490	IFI30	2.967811127	2.23E-11	5.18E-9
ENSG00000141753	IGFBP4	2.626442318	2.82E-9	4.19E-7
ENSG00000211895	IGHA1	5.190395604	4.2E-7	3.53E-5
ENSG00000211897	IGHG3	10.27955152	3.96E-9	5.66E-7
ENSG00000211592	IGKC	7.851389947	5.8E-20	4.33E-17
ENSG00000243466	IGKV1-5	11.18710843	1.80921E-4	0.005402256
ENSG00000211598	IGKV4-1	28.82560875	3.76E-6	2.25508E-4
ENSG00000211675	IGLC1	6.34868905	4.18E-5	0.001638346
ENSG00000211679	IGLC3	10.21518286	1.49747E-4	0.004638181
ENSG00000140749	IGSF6	2.877028108	9.65E-9	1.25E-6
ENSG00000162729	IGSF8	2.562415523	1.38E-10	2.65E-8
ENSG00000110324	IL10RA	3.214952058	6.68E-9	9.02E-7
ENSG00000177663	IL17RA	-1.744979535	2.36536E-4	0.006716518
ENSG00000136689	IL1RN	8.029404902	4.12E-14	1.42E-11
ENSG00000174564	IL20RB	6.093304711	7.39E-27	1.07E-23
ENSG00000147168	IL2RG	2.051628811	3.64661E-4	0.009486156
ENSG00000136718	IMP4	2.115194939	9.76E-9	1.26E-6
ENSG00000259330	INAFM2	4.829629932	2.93E-11	6.61E-9
ENSG00000115274	INO80B	2.342860014	3.84105E-4	0.009916357
ENSG00000171105	INSR	1.726791027	2.85729E-4	0.007793657
ENSG00000164880	INTS1	2.216059399	2.68E-6	1.68686E-4
ENSG00000161896	IP6K3	7.348233667	7.01E-17	3.59E-14
ENSG00000196497	IPO4	2.378902586	4.99E-6	2.84322E-4
ENSG00000205339	IPO7	1.918023648	6.98E-5	0.002490859
ENSG00000184216	IRAK1	3.267764536	2.62E-12	6.87E-10
ENSG00000128604	IRF5	2.398318035	3.87905E-4	0.009982327
ENSG00000136003	ISCU	1.905814645	8.08E-6	4.20064E-4
ENSG00000187608	ISG15	2.931092548	3.83589E-4	0.00991374
ENSG00000135424	ITGA7	1.763003986	2.67832E-4	0.007394189
ENSG00000077943	ITGA8	2.481703739	6.12E-8	6.54E-6
ENSG00000138448	ITGAV	3.092814444	5.76E-12	1.47E-9
ENSG00000160255	ITGB2	3.420579357	4.66E-10	8.25E-8
ENSG00000205726	ITSN1	-2.184030556	8.05E-6	4.19307E-4
ENSG00000161999	JMJD8	2.012796741	1.64E-5	7.62236E-4
ENSG00000143543	JTB	2.008761783	4.3E-5	0.001677441
ENSG00000177606	JUN	-3.31397013	1.30999E-4	0.004165704
ENSG00000214401	KANSL1-AS1	2.424355681	1.98601E-4	0.005824313
ENSG00000107821	KAZALD1	3.172822052	2.1E-5	9.29309E-4
ENSG00000189337	KAZN	1.909650905	5.75E-5	0.002135256
ENSG00000176407	KCMF1	2.023148235	4.11E-5	0.001612875
ENSG00000171385	KCND3	2.272268483	3.84E-7	3.28E-5
ENSG00000026559	KCNG1	38.35898931	1.18E-35	3.76E-32
ENSG00000162989	KCNJ3	2.285117489	1.69263E-4	0.00512956
ENSG00000124249	KCNK15	6.250300504	1.88E-9	2.96E-7
ENSG00000156113	KCNMA1	2.43618088	6.79E-5	0.002440534
ENSG00000117013	KCNQ4	3.799450348	1.51206E-4	0.004677312
ENSG00000134504	KCTD1	2.866007818	2.28E-10	4.24E-8
ENSG00000174943	KCTD13	1.954299954	1.18721E-4	0.00384946
ENSG00000183775	KCTD16	-18.54532426	1.67898E-4	0.005100534
ENSG00000168676	KCTD19	-4.0736238	1.6168E-4	0.004943673
ENSG00000180901	KCTD2	1.871124399	3.2792E-4	0.008696152
ENSG00000165097	KDM1B	1.779722322	8.38E-5	0.002885398
ENSG00000132510	KDM6B	1.701905089	5.49E-5	0.002049757
ENSG00000079999	KEAP1	2.100561707	2.69E-5	0.001141913
ENSG00000189367	KIAA0408	-2.864677341	3.32075E-4	0.008781966
ENSG00000100364	KIAA0930	3.285223047	2.42E-16	1.1E-13
ENSG00000122203	KIAA1191	1.986842214	6.45E-7	5.17E-5
ENSG00000130518	KIAA1683	-4.462842051	1.6E-8	1.95E-6
ENSG00000139116	KIF21A	2.02746129	1.1356E-4	0.003704736
ENSG00000068796	KIF2A	1.914721137	8.01E-5	0.002781522
ENSG00000101350	KIF3B	1.741276055	1.03732E-4	0.003435744
ENSG00000170759	KIF5B	2.612054161	2.27E-9	3.49E-7
ENSG00000168280	KIF5C	-3.978440611	2.06511E-4	0.005991621
ENSG00000166813	KIF7	3.759326061	6.84E-10	1.18E-7
ENSG00000075945	KIFAP3	1.659127643	8.94E-5	0.003049391
ENSG00000140859	KIFC3	1.943687808	2.91E-7	2.56E-5
ENSG00000157404	KIT	2.236928415	3.78E-6	2.25568E-4
ENSG00000136826	KLF4	-3.877041971	1.36E-7	1.31E-5
ENSG00000237892	KLF7-IT1	-11.20171367	2.01E-5	9.00317E-4
ENSG00000130487	KLHDC7B	8.628920401	1.92E-14	6.91E-12
ENSG00000185909	KLHDC8B	1.977618109	1.31052E-4	0.004165704
ENSG00000183655	KLHL25	3.618196787	9.12E-6	4.65E-4
ENSG00000087448	KLHL42	1.790761621	2.6516E-4	0.007341635
ENSG00000128944	KNSTRN	2.601716547	1.28E-5	6.26337E-4
ENSG00000114030	KPNA1	1.623227379	2.895E-4	0.007874028
ENSG00000182481	KPNA2	3.031276364	1.46E-5	6.93191E-4
ENSG00000186395	KRT10	3.914626436	4.61E-6	2.67027E-4
ENSG00000186847	KRT14	9.837803643	6.02E-11	1.24E-8
ENSG00000186081	KRT5	6.894233891	2.67E-8	3.12E-6
ENSG00000205420	KRT6A	8.041797134	9.05E-6	4.62467E-4
ENSG00000185479	KRT6B	17.47415131	1.88E-5	8.52516E-4
ENSG00000171396	KRTAP4-4	14.21946791	7.42E-5	0.002608687
ENSG00000198090	KRTAP4-6	8.239329894	2.26701E-4	0.006491299
ENSG00000163463	KRTCAP2	1.760670883	1.95172E-4	0.005743456
ENSG00000188508	KRTDAP	9.394730099	5.39E-5	0.002018573
ENSG00000103642	LACTB	2.142719265	8.49E-5	0.002917351
ENSG00000196976	LAGE3	2.942931967	5.02E-6	2.84854E-4
ENSG00000167613	LAIR1	2.253268895	5.69E-5	0.002112919
ENSG00000185896	LAMP1	1.895323505	1.51E-5	7.14265E-4
ENSG00000005893	LAMP2	1.907272758	3.1E-8	3.58E-6
ENSG00000078081	LAMP3	2.950247163	1.87E-6	1.2857E-4
ENSG00000188186	LAMTOR4	2.139985764	6.91E-6	3.67995E-4
ENSG00000115365	LANCL1	1.99488131	1.46E-5	6.9606E-4
ENSG00000162511	LAPTM5	2.131013448	1.95E-6	1.32306E-4
ENSG00000161813	LARP4	1.902164397	4.89E-6	2.80227E-4
ENSG00000166173	LARP6	2.79610137	1.22E-7	1.2E-5
ENSG00000136167	LCP1	3.795022504	1.44E-16	6.87E-14
ENSG00000043462	LCP2	2.23257708	3.78E-6	2.25568E-4
ENSG00000111716	LDHB	1.863149219	1.94752E-4	0.005738156
ENSG00000179241	LDLRAD3	2.118714467	4.63E-5	0.001782988
ENSG00000174697	LEP	-3.989171896	6.22E-9	8.44E-7
ENSG00000168924	LETM1	1.763245614	3.9E-5	0.001547556
ENSG00000106003	LFNG	2.901235382	2.76E-9	4.11E-7
ENSG00000100079	LGALS2	4.77873342	9.23E-5	0.003130235
ENSG00000168961	LGALS9	3.134860666	9.45E-10	1.59E-7
ENSG00000100600	LGMN	2.52805474	6.48E-11	1.33E-8
ENSG00000214269	LGMNP1	3.368554718	3.26E-7	2.84E-5
ENSG00000138039	LHCGR	-2.596554293	3.34E-5	0.001362239
ENSG00000145685	LHFPL2	2.435014294	3.42E-11	7.42E-9
ENSG00000107902	LHPP	2.224618652	2.77207E-4	0.007613399
ENSG00000064042	LIMCH1	-3.09302002	1.31E-7	1.28E-5
ENSG00000175701	LINC00116	2.205874573	3.6221E-4	0.009442955
ENSG00000232388	LINC00493	3.142993782	1.81E-7	1.7E-5
ENSG00000245060	LINC00847	2.53163912	9.63E-7	7.22E-5
ENSG00000237523	LINC00857	-5.016600798	2.15585E-4	0.006221497
ENSG00000249628	LINC00942	5.177912309	6.12E-6	3.34536E-4
ENSG00000189196	LINC00994	-9.683981894	2.398E-4	0.006772967
ENSG00000261455	LINC01003	2.827042558	3.58105E-4	0.009351247
ENSG00000260343	LINC01043	-10.93788825	9.59E-9	1.25E-6
ENSG00000260102	LINC01070	-13.25332042	6.5E-5	0.002354647
ENSG00000228794	LINC01128	2.090756017	6.82E-7	5.37E-5
ENSG00000267272	LINC01140	-4.234366102	3.55E-7	3.05E-5
ENSG00000203650	LINC01285	-3.023372514	3.54085E-4	0.009256398
ENSG00000261326	LINC01355	2.393153194	1.32E-5	6.43659E-4
ENSG00000253686	LINC01484	-3.389384305	1.26454E-4	0.004061582
ENSG00000189067	LITAF	2.506986446	1.54E-11	3.66E-9
ENSG00000164187	LMBRD2	2.160524282	1.99E-5	8.92946E-4
ENSG00000071282	LMCD1	-2.434446827	1.05E-7	1.05E-5
ENSG00000143013	LMO4	1.85668204	2.3935E-4	0.006772967
ENSG00000162761	LMX1A	-17.61178076	1.22E-6	8.87E-5
ENSG00000248494	LNX1-AS2	-7.808805022	6.51E-6	3.52279E-4
ENSG00000265489	LOC100128006	-4.199129918	1.7282E-4	0.005214173
ENSG00000254814	LOC100506113	2.573657894	1.08639E-4	0.003566114
ENSG00000251027	LOC102467213	-8.603066394	1.42302E-4	0.004436362
ENSG00000142178	LOC102724428/SIK1	-5.078460449	6.61E-7	5.25E-5
ENSG00000228436	LOC105378663	5.173215056	1.16E-10	2.25E-8
ENSG00000212743	LOC399716	-5.051036403	3.79E-5	0.001519936
ENSG00000231566	LOC401585	-27.82024556	5.43E-5	0.002031834
ENSG00000259848	LOC442028	-4.056575137	2.5502E-4	0.007115951
ENSG00000196365	LONP1	4.170192635	8.2E-26	1.09E-22
ENSG00000109771	LRP2BP	-2.700455707	1.02804E-4	0.003414477
ENSG00000137269	LRRC1	-3.87837384	1.87187E-4	0.005558551
ENSG00000079691	LRRC16A	2.174726057	4.76E-6	2.73757E-4
ENSG00000214425	LRRC37A4P	-3.960825978	5.36E-5	0.002010703
ENSG00000163428	LRRC58	1.628572228	9.09E-5	0.003093025
ENSG00000214954	LRRC69	-2.384115025	3.185E-4	0.008498267
ENSG00000171492	LRRC8D	2.204284953	3.13E-5	0.001292733
ENSG00000177363	LRRN4CL	4.194690415	1.17E-13	3.79E-11
ENSG00000181817	LSM10	3.095171171	1.03549E-4	0.003432055
ENSG00000130520	LSM4	2.949854218	2.61E-8	3.08E-6
ENSG00000153714	LURAP1L	2.494704898	3.9E-5	0.001547556
ENSG00000120992	LYPLA1	1.894196296	1.35274E-4	0.004264566
ENSG00000090382	LYZ	4.009294516	1.31E-14	4.84E-12
ENSG00000107816	LZTS2	2.13449491	6.78E-7	5.35E-5
ENSG00000116670	MAD2L2	2.872939278	1.20906E-4	0.003909678
ENSG00000178573	MAF	2.28149598	1.99E-7	1.84E-5
ENSG00000197063	MAFG	2.413639872	6.41E-9	8.67E-7
ENSG00000165509	MAGEC3	-23.50950999	2.16807E-4	0.006241674
ENSG00000147676	MAL2	3.266484754	1.28E-6	9.31E-5
ENSG00000156928	MALSU1	2.154241216	2.23E-5	9.80787E-4
ENSG00000177239	MAN1B1	1.741139356	2.02514E-4	0.005919147
ENSG00000131711	MAP1B	2.623723819	3.75E-11	8.11E-9
ENSG00000071054	MAP4K4	1.76076533	1.54105E-4	0.004757736
ENSG00000109339	MAPK10	2.47416935	5.63E-7	4.6E-5
ENSG00000008735	MAPK8IP2	4.730773919	1.96E-16	9.02E-14
ENSG00000050748	MAPK9	1.758975006	3.12E-5	0.00129157
ENSG00000162889	MAPKAPK2	2.268945743	2.35E-6	1.5284E-4
ENSG00000084764	MAPRE3	2.306147841	6.95E-8	7.31E-6
ENSG00000186868	MAPT	1.923514304	2.84E-7	2.5E-5
ENSG00000144583	MARCH4	-13.50117278	2.80293E-4	0.00767608
ENSG00000166986	MARS	2.207749706	1.74E-8	2.11E-6
ENSG00000168906	MAT2A	1.866629722	2.65E-5	0.001127807
ENSG00000103495	MAZ	2.644282046	1.24E-5	6.08766E-4
ENSG00000071655	MBD3	2.310402718	5.13E-5	0.001932844
ENSG00000129071	MBD4	2.522142866	6.55E-11	1.34E-8
ENSG00000125505	MBOAT7	2.530279491	1.57E-7	1.49E-5
ENSG00000197971	MBP	2.046100783	1.69E-5	7.83415E-4
ENSG00000126217	MCF2L	-1.962770001	9.89E-5	0.003313307
ENSG00000055732	MCOLN3	-5.108500139	2.29E-15	9.29E-13
ENSG00000187778	MCRS1	2.186415489	3.31666E-4	0.00877971
ENSG00000050393	MCUR1	2.37797015	8.17E-9	1.07E-6
ENSG00000146701	MDH2	2.232259294	7.22E-6	3.83745E-4
ENSG00000065833	ME1	2.963579175	1.31E-6	9.44E-5
ENSG00000082212	ME2	2.958264724	9.12E-12	2.26E-9
ENSG00000116353	MECR	4.622084859	7.82E-23	7.94E-20
ENSG00000105429	MEGF8	1.816462228	1.41944E-4	0.004428064
ENSG00000106780	MEGF9	3.811046823	4.65E-14	1.58E-11
ENSG00000166823	MESP1	2.468642543	4.75E-5	0.001819539
ENSG00000220884	MESTP1	-9.116716314	2.67059E-4	0.007384992
ENSG00000103260	METRN	2.675548047	3.7E-5	0.001488771
ENSG00000181038	METTL23	2.244775646	1.91115E-4	0.005656637
ENSG00000166482	MFAP4	2.961818498	7.73E-9	1.03E-6
ENSG00000156875	MFSD14A	1.952142806	1.97397E-4	0.00579821
ENSG00000148110	MFSD14B	2.098362595	2.22E-6	1.46409E-4
ENSG00000167700	MFSD3	4.029563722	1.77E-7	1.66E-5
ENSG00000182544	MFSD5	2.799571352	6.99E-8	7.34E-6
ENSG00000131446	MGAT1	1.73862213	4.58E-5	0.001767641
ENSG00000161013	MGAT4B	2.373761903	1.08E-5	5.39927E-4
ENSG00000141741	MIEN1	2.066989615	2.41965E-4	0.006813956
ENSG00000240972	MIF	3.360880745	5.2E-10	9.17E-8
ENSG00000173436	MINOS1	2.002495651	1.78E-6	1.22681E-4
ENSG00000172965	MIR4435-2HG	2.137911635	1.60953E-4	0.004927732
ENSG00000148773	MKI67	3.050590972	6.74E-7	5.32E-5
ENSG00000099875	MKNK2	2.259144095	1.75E-6	1.20973E-4
ENSG00000150051	MKX	5.289702131	1.77E-11	4.15E-9
ENSG00000119684	MLH3	1.654539498	9.43E-5	0.003182132
ENSG00000167965	MLST8	2.139855727	3.86E-5	0.001537472
ENSG00000138722	MMRN1	-4.051935669	2.54E-6	1.61913E-4
ENSG00000155229	MMS19	1.894161147	5.23E-5	0.001966884
ENSG00000070444	MNT	2.255973596	2.05673E-4	0.005978785
ENSG00000168314	MOBP	-5.465943923	1.72716E-4	0.005214173
ENSG00000075643	MOCOS	1.946481052	8.49E-5	0.002917351
ENSG00000060762	MPC1	2.769306379	2.18E-8	2.59E-6
ENSG00000129255	MPDU1	1.834240007	1.60459E-4	0.004915783
ENSG00000197629	MPEG1	2.599944378	7.92E-9	1.05E-6
ENSG00000161647	MPP3	-2.896470993	2.48277E-4	0.006962974
ENSG00000254858	MPV17L2	4.088113294	1.06E-7	1.06E-5
ENSG00000170262	MRAP	3.41974923	7.32E-5	0.002588696
ENSG00000011028	MRC2	2.20054868	6.26E-7	5.04E-5
ENSG00000158042	MRPL17	2.246284876	3.55E-5	0.001439853
ENSG00000143314	MRPL24	2.105112394	2.48E-5	0.001063798
ENSG00000116221	MRPL37	2.159859035	4.34E-5	0.001690088
ENSG00000154719	MRPL39	2.206385667	8.84E-5	0.003018717
ENSG00000111639	MRPL51	1.937521963	3.33174E-4	0.008806145
ENSG00000172590	MRPL52	2.168271766	6.8E-5	0.002441206
ENSG00000116898	MRPS15	2.613422312	2.84E-11	6.43E-9
ENSG00000182180	MRPS16	2.283391314	7.48E-9	9.98E-7
ENSG00000122140	MRPS2	2.035194616	1.04213E-4	0.003446886
ENSG00000062582	MRPS24	2.176630635	1.29E-5	6.28346E-4
ENSG00000112996	MRPS30	1.894012191	6.37E-6	3.45668E-4
ENSG00000074071	MRPS34	2.891222789	1.72E-9	2.75E-7
ENSG00000243927	MRPS6	1.867629687	1.35601E-4	0.00427207
ENSG00000149534	MS4A2	5.660164208	4.78E-6	2.74704E-4
ENSG00000110079	MS4A4A	2.489493214	1.32E-9	2.15E-7
ENSG00000110077	MS4A6A	1.88008953	9.08E-6	4.63388E-4
ENSG00000166927	MS4A7	2.499970865	5.48E-8	5.89E-6
ENSG00000178860	MSC	13.88200226	7.89E-49	4.71E-45
ENSG00000235531	MSC-AS1	5.367422678	7.67E-26	1.05E-22
ENSG00000052802	MSMO1	2.226136835	8.64E-5	0.002961546
ENSG00000038945	MSR1	3.248629255	1.0E-11	2.46E-9
ENSG00000198899	MT-ATP6	-2.78116385	2.92E-7	2.56E-5
ENSG00000228253	MT-ATP8	-2.408240209	8.82E-6	4.53043E-4
ENSG00000198804	MT-CO1	-2.794075486	2.63E-5	0.001119704
ENSG00000198712	MT-CO2	-2.281649504	1.04104E-4	0.00344569
ENSG00000198938	MT-CO3	-2.52800992	4.67E-5	0.001793449
ENSG00000198727	MT-CYB	-3.378580356	1.1E-7	1.09E-5
ENSG00000198888	MT-ND1	-2.60448425	2.27E-6	1.4851E-4
ENSG00000198763	MT-ND2	-2.643380947	1.16E-6	8.54E-5
ENSG00000198840	MT-ND3	-2.437115937	7.63E-6	4.02685E-4
ENSG00000198886	MT-ND4	-2.631102624	1.42E-6	1.00827E-4
ENSG00000212907	MT-ND4L	-2.486740869	5.16E-6	2.89484E-4
ENSG00000198786	MT-ND5	-2.560979476	2.65E-8	3.11E-6
ENSG00000198695	MT-ND6	-2.246525817	9.54E-7	7.17E-5
ENSG00000210140	MT-TC	-2.711261074	1.63E-8	1.98E-6
ENSG00000210154	MT-TD	-2.643479171	1.85257E-4	0.005516235
ENSG00000210194	MT-TE	-3.062587087	8.19E-5	0.002835451
ENSG00000209082	MT-TL1	-2.527145169	2.96E-5	0.001234115
ENSG00000210135	MT-TN	-2.501548581	2.0E-6	1.3465E-4
ENSG00000210196	MT-TP	-3.177393419	1.89E-5	8.55175E-4
ENSG00000210107	MT-TQ	-2.811972254	1.76753E-4	0.005302701
ENSG00000210151	MT-TS1	-3.987111378	2.37E-11	5.43E-9
ENSG00000210195	MT-TT	-3.748785285	9.42E-5	0.003181327
ENSG00000210144	MT-TY	-2.495116865	2.37E-7	2.13E-5
ENSG00000248527	MTATP6P1	-2.727043594	1.91E-6	1.30026E-4
ENSG00000109919	MTCH2	2.038716131	1.95113E-4	0.005743456
ENSG00000232373	MTCYBP3	-5.071646747	2.30087E-4	0.006560706
ENSG00000120254	MTHFD1L	2.355301968	3.65E-5	0.001471451
ENSG00000163719	MTMR14	2.049849452	1.12192E-4	0.003672663
ENSG00000087053	MTMR2	1.821183976	6.4E-5	0.002325813
ENSG00000225972	MTND1P23	-2.672049967	2.9E-5	0.001211306
ENSG00000225630	MTND2P28	-2.505772298	5.47E-5	0.002047477
ENSG00000250169	MTND5P13	-4.229440358	3.75453E-4	0.009708714
ENSG00000255123	MTND5P21	-8.580635256	1.47108E-4	0.004568299
ENSG00000105887	MTPN	1.921049245	6.14E-5	0.002249595
ENSG00000170873	MTSS1	1.889164412	3.1E-5	0.001287258
ENSG00000132613	MTSS1L	2.701411306	1.11E-6	8.21E-5
ENSG00000172551	MUCL1	7.50654611	2.81625E-4	0.007702586
ENSG00000167508	MVD	3.066826217	1.35E-12	3.72E-10
ENSG00000182534	MXRA7	3.262040698	1.06E-22	1.04E-19
ENSG00000132382	MYBBP1A	2.073001835	1.5E-6	1.05485E-4
ENSG00000172927	MYEOV	-10.68815226	6.91E-8	7.28E-6
ENSG00000144821	MYH15	3.42498632	6.76E-8	7.14E-6
ENSG00000101608	MYL12A	2.022387814	4.52E-8	5.02E-6
ENSG00000118680	MYL12B	1.742658214	4.96E-5	0.001881089
ENSG00000101335	MYL9	2.230166198	1.44E-6	1.01729E-4
ENSG00000176658	MYO1D	1.881356727	7.48E-5	0.002621583
ENSG00000197535	MYO5A	2.636984313	5.82E-18	3.75E-15
ENSG00000128833	MYO5C	-2.039928303	3.89E-5	0.001547556
ENSG00000034971	MYOC	-8.959406169	2.55E-9	3.85E-7
ENSG00000166268	MYRFL	7.44043288	1.07E-10	2.1E-8
ENSG00000152082	MZT2B	2.620796646	1.08199E-4	0.003561466
ENSG00000102030	NAA10	2.320510588	9.61E-9	1.25E-6
ENSG00000196531	NACA	1.604888097	2.94315E-4	0.007991343
ENSG00000121089	NACA3P	-16.94015394	8.21E-11	1.66E-8
ENSG00000136274	NACAD	-4.787378237	5.38E-5	0.002016148
ENSG00000160877	NACC1	2.507079643	2.02E-8	2.43E-6
ENSG00000148411	NACC2	1.91906878	1.38904E-4	0.004353141
ENSG00000108784	NAGLU	2.072485741	3.74519E-4	0.009689826
ENSG00000188613	NANOS1	6.944306969	4.85E-50	3.31E-46
ENSG00000205531	NAP1L4	4.438299764	2.12E-27	3.17E-24
ENSG00000105402	NAPA	1.923847521	2.0E-5	8.9719E-4
ENSG00000134440	NARS	1.790180381	2.10885E-4	0.006101979
ENSG00000149294	NCAM1	-2.264991519	1.42E-5	6.7965E-4
ENSG00000020129	NCDN	2.264388535	4.08E-6	2.41146E-4
ENSG00000123338	NCKAP1L	2.353007106	7.74E-6	4.07648E-4
ENSG00000162736	NCSTN	2.672317109	4.56E-9	6.38E-7
ENSG00000125356	NDUFA1	2.17754191	8.37E-6	4.32484E-4
ENSG00000174886	NDUFA11	2.000981155	1.42E-5	6.7965E-4
ENSG00000184752	NDUFA12	2.158563594	4.06E-5	0.001598921
ENSG00000186010	NDUFA13	2.732809413	2.6E-6	1.65154E-4
ENSG00000131495	NDUFA2	1.867565913	3.57E-5	0.00144572
ENSG00000189043	NDUFA4	2.064404219	2.82E-5	0.001186526
ENSG00000185633	NDUFA4L2	2.615033635	1.15E-7	1.14E-5
ENSG00000184983	NDUFA6	1.88637345	1.22022E-4	0.003937771
ENSG00000139180	NDUFA9	2.219044901	1.92E-7	1.78E-5
ENSG00000004779	NDUFAB1	2.458239137	5.22E-6	2.91031E-4
ENSG00000178057	NDUFAF3	2.536149424	1.53E-8	1.9E-6
ENSG00000090266	NDUFB2	1.979731112	5.22E-6	2.91187E-4
ENSG00000065518	NDUFB4	2.279586827	1.61E-6	1.12556E-4
ENSG00000151366	NDUFC2	2.152817781	2.36E-6	1.5284E-4
ENSG00000213619	NDUFS3	1.777483334	1.60144E-4	0.00491519
ENSG00000164258	NDUFS4	1.966308835	2.53207E-4	0.007080445
ENSG00000110717	NDUFS8	2.262738625	9.85E-8	1.0E-5
ENSG00000188986	NELFB	1.953224918	3.58944E-4	0.009368034
ENSG00000204356	NELFE	1.919523325	2.08E-5	9.22686E-4
ENSG00000067141	NEO1	2.17447202	1.33E-5	6.43848E-4
ENSG00000082641	NFE2L1	1.906033832	2.41E-5	0.001039079
ENSG00000116044	NFE2L2	2.070857971	7.45E-8	7.77E-6
ENSG00000182768	NGRN	2.365893598	2.21E-12	5.91E-10
ENSG00000171786	NHLH1	9.91362728	7.58E-22	6.46E-19
ENSG00000145912	NHP2	2.097260049	8.31E-6	4.31019E-4
ENSG00000131669	NINJ1	4.279415853	1.08E-12	3.05E-10
ENSG00000136783	NIPSNAP3A	2.105998183	6.83E-5	0.002446998
ENSG00000168256	NKIRAS2	2.252472937	1.02E-6	7.61E-5
ENSG00000169760	NLGN1	-3.134928189	2.71461E-4	0.007472757
ENSG00000091106	NLRC4	3.726135192	1.47015E-4	0.004568299
ENSG00000239672	NME1	2.944886116	9.02E-12	2.24E-9
ENSG00000011052	NME1-NME2	2.635564909	1.19E-7	1.17E-5
ENSG00000243678	NME2	3.665851506	2.33E-7	2.11E-5
ENSG00000157064	NMNAT2	-2.155980607	3.86E-5	0.001537472
ENSG00000152465	NMT2	1.722511564	8.97E-6	4.5946E-4
ENSG00000166741	NNMT	-2.249344866	3.23708E-4	0.008613162
ENSG00000165271	NOL6	2.092691418	5.08E-5	0.001919228
ENSG00000249673	NOP14-AS1	2.081576465	3.72E-5	0.001491329
ENSG00000170485	NPAS2	5.41355186	3.4E-31	7.39E-28
ENSG00000119655	NPC2	2.131790683	2.91E-6	1.81197E-4
ENSG00000135838	NPL	2.474217268	2.50153E-4	0.007003251
ENSG00000239351	NPM1P29	3.802454696	3.24E-5	0.001330468
ENSG00000113389	NPR3	-4.079912292	2.23959E-4	0.006416634
ENSG00000221890	NPTXR	3.161106557	9.72E-13	2.78E-10
ENSG00000164128	NPY1R	-4.694364836	6.01E-6	3.29379E-4
ENSG00000181019	NQO1	5.028842527	4.79E-32	1.14E-28
ENSG00000126368	NR1D1	3.930129112	3.59E-22	3.3E-19
ENSG00000184162	NR2C2AP	2.146547084	7.89E-5	0.002744614
ENSG00000160113	NR2F6	2.062514293	6.22E-5	0.00227216
ENSG00000123358	NR4A1	-8.304083705	1.76E-5	8.0679E-4
ENSG00000153234	NR4A2	-7.299105593	1.97042E-4	0.005791349
ENSG00000116833	NR5A2	-1.989794227	2.87E-5	0.001201134
ENSG00000148572	NRBF2	2.049492334	2.32E-5	0.001009163
ENSG00000115216	NRBP1	1.700366644	2.1857E-4	0.006281049
ENSG00000124785	NRN1	2.038704959	4.47E-5	0.001730687
ENSG00000174004	NRROS	3.028231535	1.78E-5	8.15366E-4
ENSG00000125841	NRSN2	2.088008368	2.67E-5	0.001132585
ENSG00000035681	NSMAF	3.411022792	2.38E-17	1.42E-14
ENSG00000165802	NSMF	2.975009195	3.92E-9	5.64E-7
ENSG00000140538	NTRK3	-4.963289769	2.72E-9	4.08E-7
ENSG00000183828	NUDT14	1.73714108	3.87088E-4	0.00997718
ENSG00000226328	NUP50-AS1	4.61693545	6.36E-7	5.11E-5
ENSG00000176046	NUPR1	3.891215009	2.87E-32	7.21E-29
ENSG00000182379	NXPH4	8.869135925	1.93E-28	3.3E-25
ENSG00000184232	OAF	3.896921168	6.36E-19	4.34E-16
ENSG00000104904	OAZ1	1.9015058	1.75E-5	8.02726E-4
ENSG00000115758	ODC1	3.383223441	3.07E-13	9.35E-11
ENSG00000087263	OGFOD1	1.657300796	1.81574E-4	0.005414551
ENSG00000147162	OGT	1.777145484	9.25E-5	0.003134804
ENSG00000164815	ORC5	2.201820365	7.48E-5	0.002621583
ENSG00000144909	OSBPL11	3.206789785	7.83E-12	1.97E-9
ENSG00000116885	OSCP1	2.777014677	5.58E-7	4.58E-5
ENSG00000140961	OSGIN1	7.349852104	3.85E-22	3.47E-19
ENSG00000228474	OST4	1.964105213	2.0896E-4	0.00605405
ENSG00000081087	OSTM1	2.559998543	2.27E-12	5.99E-10
ENSG00000089723	OTUB2	3.290573323	1.54E-8	1.91E-6
ENSG00000262664	OVCA2	31.31131329	7.6E-6	4.01515E-4
ENSG00000204237	OXLD1	2.777065045	7.17E-5	0.002550475
ENSG00000089041	P2RX7	2.48338797	1.20725E-4	0.003907548
ENSG00000169313	P2RY12	3.981014362	1.28E-5	6.26337E-4
ENSG00000072682	P4HA2	1.973600624	5.09E-5	0.001921634
ENSG00000179364	PACS2	1.659786892	1.80976E-4	0.005402256
ENSG00000165912	PACSIN3	2.94872198	6.17E-6	3.3681E-4
ENSG00000168092	PAFAH1B2	1.552006687	2.56766E-4	0.007150677
ENSG00000076641	PAG1	2.511617614	2.0E-8	2.41E-6
ENSG00000217930	PAM16	2.652682929	2.41E-7	2.16E-5
ENSG00000120137	PANK3	1.957158236	1.11E-7	1.1E-5
ENSG00000110218	PANX1	3.471067113	1.28E-9	2.09E-7
ENSG00000163291	PAQR3	1.783755111	1.59524E-4	0.004902842
ENSG00000116288	PARK7	1.824393751	2.1504E-4	0.006209501
ENSG00000175198	PCCA	-2.109297118	3.03485E-4	0.008184501
ENSG00000114054	PCCB	1.794375139	2.39664E-4	0.006772967
ENSG00000165194	PCDH19	-2.068076928	2.28863E-4	0.006541429
ENSG00000248383	PCDHAC1	9.539313413	5.24E-28	8.35E-25
ENSG00000243232	PCDHAC2	12.25035174	9.08E-21	7.61E-18
ENSG00000100982	PCIF1	1.918779023	2.44929E-4	0.006873116
ENSG00000100889	PCK2	2.773596244	4.91E-8	5.34E-6
ENSG00000186472	PCLO	-4.298081271	1.25E-7	1.22E-5
ENSG00000140479	PCSK6	-2.76366484	4.29E-5	0.001675812
ENSG00000115539	PDCL3	2.927306173	2.0E-7	1.85E-5
ENSG00000154678	PDE1C	2.999621163	3.42E-6	2.09061E-4
ENSG00000113231	PDE8B	-2.710170888	2.1E-5	9.29461E-4
ENSG00000197461	PDGFA	2.683045781	4.8E-8	5.26E-6
ENSG00000145431	PDGFC	1.934240935	3.23893E-4	0.008613274
ENSG00000143870	PDIA6	1.802311341	2.67616E-4	0.007392478
ENSG00000131435	PDLIM4	3.107467387	2.39E-5	0.001033446
ENSG00000241360	PDXP	4.871961868	2.56E-7	2.27E-5
ENSG00000067840	PDZD4	-4.599451604	2.31897E-4	0.006596566
ENSG00000162734	PEA15	3.584426472	3.29E-23	3.42E-20
ENSG00000089220	PEBP1	1.893378105	1.38E-5	6.65796E-4
ENSG00000242265	PEG10	6.315750179	9.1E-52	7.24E-48
ENSG00000179094	PER1	-2.500211405	6.4E-5	0.002325021
ENSG00000157911	PEX10	2.5141209	3.83E-5	0.001531716
ENSG00000034693	PEX3	2.653232156	3.97E-6	2.35139E-4
ENSG00000123349	PFDN5	1.61465993	2.74491E-4	0.007551811
ENSG00000158571	PFKFB1	-4.178997351	4.14E-6	2.44199E-4
ENSG00000170525	PFKFB3	-4.367957386	3.72E-8	4.23E-6
ENSG00000141959	PFKL	1.83685019	9.94E-5	0.003328268
ENSG00000108518	PFN1	2.118093513	3.56E-6	2.15249E-4
ENSG00000171314	PGAM1	2.143813108	6.59E-5	0.002381765
ENSG00000142657	PGD	3.250982165	3.22E-13	9.73E-11
ENSG00000184207	PGP	2.45678207	2.43769E-4	0.00684863
ENSG00000215021	PHB2	1.904160825	1.24122E-4	0.004002836
ENSG00000181649	PHLDA2	6.981810692	1.07E-7	1.07E-5
ENSG00000174307	PHLDA3	2.555057045	4.44E-9	6.24E-7
ENSG00000144824	PHLDB2	-1.819051671	1.72758E-4	0.005214173
ENSG00000054148	PHPT1	2.796600972	1.11E-10	2.18E-8
ENSG00000124102	PI3	8.096993165	3.71E-5	0.001490113
ENSG00000241973	PI4KA	1.680483772	1.98129E-4	0.005816122
ENSG00000142892	PIGK	2.127447696	3.38797E-4	0.008925139
ENSG00000155629	PIK3AP1	2.747730113	4.28E-6	2.51522E-4
ENSG00000105851	PIK3CG	2.407191423	3.10908E-4	0.008337613
ENSG00000145675	PIK3R1	-2.091483406	1.85489E-4	0.005516275
ENSG00000117461	PIK3R3	1.644974071	1.94198E-4	0.005725362
ENSG00000198355	PIM3	1.980426949	2.82288E-4	0.007704217
ENSG00000159763	PIP	9.53439438	6.04E-5	0.002220387
ENSG00000186111	PIP5K1C	1.908450734	6.29E-5	0.00229291
ENSG00000087842	PIR	2.797081095	8.15E-10	1.38E-7
ENSG00000067225	PKM	3.070521925	3.42E-13	1.03E-10
ENSG00000123143	PKN1	2.371108336	5.13E-8	5.56E-6
ENSG00000188257	PLA2G2A	2.261504458	5.17E-6	2.89484E-4
ENSG00000137055	PLAA	2.366075482	2.27E-7	2.06E-5
ENSG00000151176	PLBD2	2.442767502	3.04E-6	1.88387E-4
ENSG00000137841	PLCB2	2.305182434	6.82E-5	0.002445367
ENSG00000138193	PLCE1	-2.222625882	1.74795E-4	0.005263813
ENSG00000105223	PLD3	2.101148669	1.36E-5	6.57403E-4
ENSG00000115956	PLEK	2.588220316	4.58E-6	2.65695E-4
ENSG00000225190	PLEKHM1	1.631503179	1.05393E-4	0.003481093
ENSG00000116786	PLEKHM2	2.336541638	2.13E-6	1.41534E-4
ENSG00000241839	PLEKHO2	3.628367413	2.37E-19	1.69E-16
ENSG00000107020	PLGRKT	2.408460458	1.19319E-4	0.003866217
ENSG00000166819	PLIN1	-2.318884925	1.79E-5	8.19E-4
ENSG00000147872	PLIN2	4.489894497	9.31E-39	3.42E-35
ENSG00000214456	PLIN5	-2.581977287	4.69E-6	2.70694E-4
ENSG00000106397	PLOD3	1.858141995	1.06E-5	5.29437E-4
ENSG00000067113	PLPP1	1.953450431	1.36484E-4	0.004291399
ENSG00000100979	PLTP	3.145521684	2.99E-10	5.49E-8
ENSG00000114554	PLXNA1	2.759796109	3.01E-11	6.72E-9
ENSG00000196576	PLXNB2	2.058929773	1.64E-5	7.645E-4
ENSG00000004399	PLXND1	2.122428937	1.66E-7	1.57E-5
ENSG00000163344	PMVK	1.950406343	6.49E-5	0.002354647
ENSG00000127838	PNKD	1.904017193	1.05487E-4	0.003481794
ENSG00000176903	PNMA1	2.21847006	7.15E-7	5.58E-5
ENSG00000115946	PNO1	1.871440477	2.78639E-4	0.007635148
ENSG00000189266	PNRC2	1.787462988	4.86E-5	0.001853577
ENSG00000106628	POLD2	2.368027413	7.08E-5	0.002521738
ENSG00000004142	POLDIP2	2.224273076	1.91E-6	1.30073E-4
ENSG00000130997	POLN	-3.052305034	6.62E-7	5.26E-5
ENSG00000168002	POLR2G	2.358674901	1.77E-5	8.12397E-4
ENSG00000105258	POLR2I	2.31945638	1.65046E-4	0.005027265
ENSG00000147669	POLR2K	2.053888264	1.15981E-4	0.003772035
ENSG00000099821	POLRMT	1.902157072	3.87915E-4	0.009982327
ENSG00000085998	POMGNT1	2.099283765	9.44E-7	7.12E-5
ENSG00000132963	POMP	1.809439865	1.68336E-4	0.005107934
ENSG00000127948	POR	2.764963376	1.12E-11	2.72E-9
ENSG00000106536	POU6F2	-4.225172376	1.8E-5	8.19E-4
ENSG00000138777	PPA2	1.913231305	4.65E-5	0.001787857
ENSG00000125534	PPDPF	3.514526133	9.07E-15	3.47E-12
ENSG00000166387	PPFIBP2	1.843100696	3.95E-6	2.34162E-4
ENSG00000196262	PPIA	2.024798357	3.48E-6	2.11453E-4
ENSG00000137168	PPIL1	3.369476928	2.69726E-4	0.007437874
ENSG00000172531	PPP1CA	2.230973196	1.07E-5	5.3616E-4
ENSG00000204619	PPP1R11	2.111707314	2.75E-8	3.2E-6
ENSG00000173457	PPP1R14B	3.501822852	2.45E-9	3.76E-7
ENSG00000146112	PPP1R18	2.127665381	3.0E-6	1.85855E-4
ENSG00000131771	PPP1R1B	-5.666585274	2.07E-9	3.2E-7
ENSG00000184203	PPP1R2	1.611446626	2.63385E-4	0.00730944
ENSG00000108819	PPP1R9B	2.094309255	1.16704E-4	0.003791759
ENSG00000137713	PPP2R1B	2.072479723	1.01E-7	1.02E-5
ENSG00000119383	PPP2R4	1.969755375	1.16018E-4	0.003772035
ENSG00000131238	PPT1	2.718099121	3.85E-7	3.28E-5
ENSG00000196850	PPTC7	1.847941572	7.3E-5	0.002584789
ENSG00000214140	PRCD	2.176899947	1.85405E-4	0.005516275
ENSG00000126432	PRDX5	2.48891712	1.32E-7	1.28E-5
ENSG00000138073	PREB	3.012689996	1.03E-7	1.03E-5
ENSG00000169230	PRELID1	2.17635723	1.1E-6	8.14E-5
ENSG00000101166	PRELID3B	2.169986049	1.4E-5	6.74731E-4
ENSG00000188783	PRELP	-2.692633496	1.38E-7	1.32E-5
ENSG00000138078	PREPL	1.837503117	9.17E-5	0.003112967
ENSG00000124126	PREX1	2.673627734	2.0E-7	1.85E-5
ENSG00000241111	PRICKLE2-AS1	-6.883459412	6.5E-5	0.002354647
ENSG00000142875	PRKACB	1.991323313	2.95513E-4	0.008014753
ENSG00000180228	PRKRA	2.297409115	2.41E-6	1.54933E-4
ENSG00000185238	PRMT3	2.31156787	2.63053E-4	0.007304468
ENSG00000100462	PRMT5	1.862648503	8.1E-5	0.002812004
ENSG00000171867	PRNP	2.76085988	7.91E-9	1.05E-6
ENSG00000147471	PROSC	1.840060371	2.40291E-4	0.006782815
ENSG00000230082	PRRT3-AS1	3.434137936	1.1E-7	1.09E-5
ENSG00000197746	PSAP	2.620115402	1.07E-14	4.03E-12
ENSG00000135069	PSAT1	9.971177656	1.08E-42	4.32E-39
ENSG00000100567	PSMA3	2.079961875	6.83E-6	3.65446E-4
ENSG00000041357	PSMA4	1.797063883	3.07E-4	0.008269953
ENSG00000100902	PSMA6	1.556443087	1.28343E-4	0.004107439
ENSG00000205220	PSMB10	3.293623907	1.96E-9	3.06E-7
ENSG00000126067	PSMB2	1.969085573	1.78E-5	8.1359E-4
ENSG00000159377	PSMB4	1.835306171	3.51663E-4	0.00920822
ENSG00000142507	PSMB6	2.19463842	4.68E-8	5.18E-6
ENSG00000136930	PSMB7	2.011748836	3.91E-5	0.001550968
ENSG00000013275	PSMC4	2.203898358	7.65E-8	7.96E-6
ENSG00000115233	PSMD14	2.216953295	7.96E-6	4.15908E-4
ENSG00000175166	PSMD2	1.928954659	7.55E-6	3.99231E-4
ENSG00000103035	PSMD7	2.091968801	9.25E-6	4.71154E-4
ENSG00000099341	PSMD8	1.983775195	2.54E-5	0.001086869
ENSG00000092010	PSME1	1.869162552	7.35E-5	0.002591459
ENSG00000183527	PSMG1	1.999595584	1.21795E-4	0.003933104
ENSG00000165983	PTER	2.492405095	2.68E-6	1.68686E-4
ENSG00000122420	PTGFR	2.705312761	2.88E-5	0.001205343
ENSG00000081237	PTPRC	2.274870032	8.77E-7	6.71E-5
ENSG00000149177	PTPRJ	2.400519266	2.8E-6	1.75402E-4
ENSG00000152894	PTPRK	2.669011124	1.21E-12	3.4E-10
ENSG00000139304	PTPRQ	-3.394476836	7.68E-5	0.002677087
ENSG00000163661	PTX3	4.360833751	7.79E-8	8.08E-6
ENSG00000171813	PWWP2B	3.179698322	1.18E-6	8.63E-5
ENSG00000168994	PXDC1	2.143400718	3.3E-6	2.02723E-4
ENSG00000168297	PXK	2.488971472	9.99E-7	7.46E-5
ENSG00000100994	PYGB	2.225659189	4.07E-6	2.40841E-4
ENSG00000116260	QSOX1	2.119264249	2.05E-7	1.89E-5
ENSG00000084733	RAB10	1.665022018	1.76284E-4	0.005295276
ENSG00000107560	RAB11FIP2	1.921217165	1.61E-5	7.55044E-4
ENSG00000118508	RAB32	5.83496878	5.81E-24	6.6E-21
ENSG00000108774	RAB5C	1.738539256	1.14273E-4	0.003722928
ENSG00000075785	RAB7A	1.943731673	2.17E-6	1.43994E-4
ENSG00000166128	RAB8B	1.83138888	1.31398E-4	0.004167143
ENSG00000123595	RAB9A	2.578318459	2.34E-6	1.52382E-4
ENSG00000196642	RABL6	1.890222553	3.44E-6	2.09804E-4
ENSG00000136238	RAC1	1.646735029	5.13E-5	0.001932844
ENSG00000131477	RAMP2	1.926417161	1.76893E-4	0.005303561
ENSG00000122679	RAMP3	2.459037182	1.2779E-4	0.004095145
ENSG00000132341	RAN	2.017396177	6.49E-7	5.19E-5
ENSG00000138698	RAP1GDS1	2.403840399	2.65E-10	4.88E-8
ENSG00000125249	RAP2A	2.370008241	1.94E-7	1.81E-5
ENSG00000133321	RARRES3	3.435506523	8.07E-6	4.2006E-4
ENSG00000108551	RASD1	-2.45719288	1.59E-5	7.44659E-4
ENSG00000125826	RBCK1	2.652107116	1.17E-11	2.82E-9
ENSG00000119446	RBM18	2.069439493	7.83E-5	0.002728784
ENSG00000132819	RBM38	2.613543079	2.61694E-4	0.007278709
ENSG00000166831	RBPMS2	1.890013226	3.2487E-4	0.008629654
ENSG00000100387	RBX1	2.028964505	5.04E-6	2.85512E-4
ENSG00000179051	RCC2	2.030083049	5.45E-6	3.02419E-4
ENSG00000167771	RCOR2	4.831107674	1.43E-5	6.84559E-4
ENSG00000165731	RET	4.075598359	2.72E-15	1.09E-12
ENSG00000169733	RFNG	3.082784183	1.35E-8	1.7E-6
ENSG00000143344	RGL1	2.030141099	6.91E-6	3.67995E-4
ENSG00000144468	RHBDD1	1.915199612	3.30796E-4	0.008762691
ENSG00000005486	RHBDD2	4.384045128	6.92E-19	4.65E-16
ENSG00000106615	RHEB	1.932091848	9.44E-7	7.12E-5
ENSG00000008853	RHOBTB2	2.782283399	1.88E-6	1.28643E-4
ENSG00000177105	RHOG	2.194660021	1.5E-6	1.05342E-4
ENSG00000167705	RILP	2.129854435	1.06E-5	5.32419E-4
ENSG00000188026	RILPL1	2.193305597	2.91E-5	0.001215282
ENSG00000117016	RIMS3	6.740073813	4.29E-12	1.11E-9
ENSG00000101098	RIMS4	5.58031594	4.86E-8	5.31E-6
ENSG00000229456	RLIMP1	-3.04578267	2.01752E-4	0.005900829
ENSG00000264352	RN7SL602P	-4.83042343	3.39752E-4	0.008940438
ENSG00000129538	RNASE1	3.600194268	1.72E-13	5.44E-11
ENSG00000169413	RNASE6	5.058419914	1.67E-14	6.04E-12
ENSG00000219200	RNASEK	2.267650843	8.99E-6	4.59788E-4
ENSG00000181481	RNF135	2.139373725	9.3E-6	4.72939E-4
ENSG00000151692	RNF144A	-2.191653511	2.43004E-4	0.006835162
ENSG00000141576	RNF157	1.918013177	7.65E-7	5.92E-5
ENSG00000141622	RNF165	2.60146964	2.1E-6	1.3981E-4
ENSG00000108523	RNF167	1.754117202	2.69359E-4	0.007432037
ENSG00000138942	RNF185	2.879601008	2.61E-13	8.1E-11
ENSG00000168159	RNF187	3.454759239	1.59E-16	7.46E-14
ENSG00000101236	RNF24	2.210072129	3.16E-5	0.001301968
ENSG00000173456	RNF26	2.220138349	4.29E-5	0.001675232
ENSG00000146083	RNF44	2.31936792	2.71E-6	1.69847E-4
ENSG00000023191	RNH1	2.19424475	3.09E-8	3.57E-6
ENSG00000142327	RNPEPL1	2.204992279	3.41E-6	2.0892E-4
ENSG00000198963	RORB	-8.303263316	2.16743E-4	0.006241674
ENSG00000204086	RPA4	-46.92702059	1.2923E-4	0.004123005
ENSG00000197713	RPE	2.405400758	4.79E-7	4.0E-5
ENSG00000230734	RPL10P3	1.990988056	4.5E-6	2.61564E-4
ENSG00000197958	RPL12	2.285687336	8.94E-7	6.84E-5
ENSG00000265681	RPL17	1.920489901	1.1174E-4	0.003661498
ENSG00000063177	RPL18	2.124856065	4.72E-5	0.001809638
ENSG00000105640	RPL18A	1.927524703	2.78112E-4	0.007625084
ENSG00000108298	RPL19	1.956384395	1.02E-5	5.14303E-4
ENSG00000161970	RPL26	1.896650512	6.7E-5	0.002413711
ENSG00000108107	RPL28	2.194904628	1.38E-6	9.85E-5
ENSG00000162244	RPL29	1.843713674	1.65295E-4	0.005031652
ENSG00000156482	RPL30	1.69032951	7.32E-5	0.002588375
ENSG00000071082	RPL31	1.934690816	2.03E-5	9.02496E-4
ENSG00000144713	RPL32	2.039266475	5.66E-5	0.002102814
ENSG00000136942	RPL35	1.963070958	1.51578E-4	0.004685779
ENSG00000130255	RPL36	2.544599415	8.07E-8	8.34E-6
ENSG00000145592	RPL37	1.842189576	2.25E-5	9.85898E-4
ENSG00000197756	RPL37A	2.457572774	3.96E-7	3.36E-5
ENSG00000172809	RPL38	2.019582527	1.72E-5	7.93661E-4
ENSG00000174444	RPL4	1.763757735	1.7096E-4	0.005171131
ENSG00000229117	RPL41	2.215199314	5.87E-7	4.77E-5
ENSG00000148303	RPL7A	1.858011477	2.49744E-4	0.006995904
ENSG00000089157	RPLP0	1.883681874	1.05166E-4	0.003476005
ENSG00000137818	RPLP1	2.319640227	8.28E-7	6.35E-5
ENSG00000118705	RPN2	2.208324292	4.99E-7	4.14E-5
ENSG00000124614	RPS10	2.387482698	9.24E-7	7.01E-5
ENSG00000112306	RPS12	2.584780892	2.87E-9	4.26E-7
ENSG00000110700	RPS13	1.935166028	4.55E-5	0.001756076
ENSG00000115268	RPS15	2.040389478	8.63E-5	0.002961362
ENSG00000134419	RPS15A	1.962504679	2.77689E-4	0.007622243
ENSG00000105193	RPS16	1.947078654	2.21432E-4	0.006355658
ENSG00000105372	RPS19	2.303885194	8.96E-6	4.59441E-4
ENSG00000140988	RPS2	2.514577199	4.91E-8	5.34E-6
ENSG00000171858	RPS21	2.208356155	1.41194E-4	0.004410441
ENSG00000186468	RPS23	1.881880372	3.65494E-4	0.009497484
ENSG00000138326	RPS24	1.758485022	3.08123E-4	0.008288711
ENSG00000185088	RPS27L	2.007587785	6.11E-6	3.34536E-4
ENSG00000213741	RPS29	2.343604064	2.68E-5	0.001137865
ENSG00000145425	RPS3A	1.68778084	2.64352E-4	0.007327753
ENSG00000198034	RPS4X	1.848386815	2.29648E-4	0.006554735
ENSG00000239830	RPS4XP22	-11.37968501	1.37E-6	9.79E-5
ENSG00000229920	RPS4XP5	-5.464443861	7.74E-6	4.07648E-4
ENSG00000083845	RPS5	2.29117088	2.26E-6	1.47773E-4
ENSG00000142937	RPS8	2.020443872	1.99E-6	1.34606E-4
ENSG00000168028	RPSA	2.004215008	2.56E-5	0.001095257
ENSG00000156990	RPUSD3	1.997980292	6.0E-5	0.002214174
ENSG00000116954	RRAGC	2.338204998	1.33E-8	1.68E-6
ENSG00000025039	RRAGD	2.197684548	6.2E-5	0.002265789
ENSG00000048392	RRM2B	2.471159897	5.8E-6	3.19955E-4
ENSG00000257122	RRN3P3	-3.387504964	1.76399E-4	0.00529542
ENSG00000160208	RRP1B	2.072911658	3.31E-5	0.001353181
ENSG00000124541	RRP36	2.429001017	9.15E-5	0.003106733
ENSG00000169218	RSPO1	-11.56760489	3.39729E-4	0.008940438
ENSG00000146374	RSPO3	-3.284304915	1.4E-5	6.73363E-4
ENSG00000133318	RTN3	2.038859652	3.94E-6	2.33979E-4
ENSG00000115310	RTN4	2.293257684	4.61E-6	2.67027E-4
ENSG00000018189	RUFY3	2.070307576	1.75E-5	8.02726E-4
ENSG00000105784	RUNDC3B	-7.715965802	1.1E-5	5.48658E-4
ENSG00000160678	S100A1	-10.64416891	3.04E-10	5.55E-8
ENSG00000163191	S100A11	2.376006568	2.04E-8	2.44E-6
ENSG00000196754	S100A2	7.228580533	1.34E-7	1.29E-5
ENSG00000143556	S100A7	19.63007873	8.82E-10	1.49E-7
ENSG00000143546	S100A8	5.022767447	2.27306E-4	0.006504723
ENSG00000173432	SAA1	-8.006157121	1.63E-6	1.13381E-4
ENSG00000134339	SAA2	-4.704847554	7.42E-5	0.002608687
ENSG00000142230	SAE1	1.941153987	7.78E-7	6.01E-5
ENSG00000031698	SARS	2.776599378	2.13E-11	4.96E-9
ENSG00000100241	SBF1	2.381664756	5.63E-7	4.6E-5
ENSG00000140497	SCAMP2	2.021998706	5.19E-6	2.89798E-4
ENSG00000116521	SCAMP3	2.337263545	5.06E-6	2.86152E-4
ENSG00000099194	SCD	2.822002005	5.25E-6	2.91828E-4
ENSG00000136531	SCN2A	-5.724236305	1.93328E-4	0.005706771
ENSG00000168447	SCNN1B	-4.531948905	1.38359E-4	0.004344612
ENSG00000130489	SCO2	2.745195923	2.25E-6	1.47773E-4
ENSG00000121064	SCPEP1	1.935025548	1.14953E-4	0.003742526
ENSG00000136193	SCRN1	3.540607969	1.18E-16	5.73E-14
ENSG00000159307	SCUBE1	3.788048701	1.47E-5	6.97704E-4
ENSG00000136021	SCYL2	1.872179009	1.34482E-4	0.004248009
ENSG00000162512	SDC3	3.280824383	3.79E-15	1.48E-12
ENSG00000124145	SDC4	2.622973759	4.49E-8	5.0E-6
ENSG00000137575	SDCBP	2.133772683	8.98E-7	6.84E-5
ENSG00000132581	SDF2	2.036407734	2.09023E-4	0.00605405
ENSG00000205138	SDHAF1	3.388810588	1.54542E-4	0.004765055
ENSG00000117118	SDHB	2.357732296	1.44E-5	6.86721E-4
ENSG00000143252	SDHC	2.070866182	1.08184E-4	0.003561466
ENSG00000058262	SEC61A1	2.272088886	1.37E-7	1.31E-5
ENSG00000106803	SEC61B	2.095672085	2.75E-5	0.001159427
ENSG00000071537	SEL1L	2.508861491	2.16E-10	4.05E-8
ENSG00000075223	SEMA3C	2.10762637	1.2E-5	5.92351E-4
ENSG00000185033	SEMA4B	-2.3119614	2.39246E-4	0.006772967
ENSG00000161956	SENP3	2.000409535	3.36009E-4	0.008871256
ENSG00000179918	SEPHS2	2.740283884	4.12E-16	1.81E-13
ENSG00000100167	SEPT3	5.348695802	6.97E-9	9.35E-7
ENSG00000184640	SEPT9	1.91227472	7.47E-5	0.002621583
ENSG00000168528	SERINC2	5.288234956	7.06E-17	3.59E-14
ENSG00000135919	SERPINE2	2.303469613	9.88E-7	7.39E-5
ENSG00000130766	SESN2	4.154022885	3.97E-17	2.2E-14
ENSG00000169976	SF3B5	2.236725922	8.78E-5	0.003002592
ENSG00000104332	SFRP1	-2.602774812	1.35E-6	9.71E-5
ENSG00000106483	SFRP4	-4.479992454	1.25229E-4	0.004033069
ENSG00000213064	SFT2D2	2.152081737	5.4E-6	2.99883E-4
ENSG00000183605	SFXN4	2.344952372	3.18361E-4	0.008498267
ENSG00000102683	SGCG	2.082975254	2.33819E-4	0.006643337
ENSG00000176476	SGF29	2.040142757	4.17E-5	0.001633539
ENSG00000166224	SGPL1	2.098626145	2.53E-7	2.26E-5
ENSG00000111252	SH2B3	2.370415861	2.42E-10	4.48E-8
ENSG00000142669	SH3BGRL3	2.106908768	7.52E-5	0.002632909
ENSG00000097033	SH3GLB1	2.244421625	3.09E-7	2.7E-5
ENSG00000172985	SH3RF3	2.801068979	3.6E-10	6.5E-8
ENSG00000107338	SHB	3.453308035	9.21E-7	6.99E-5
ENSG00000182199	SHMT2	4.559130295	1.01E-20	8.33E-18
ENSG00000108061	SHOC2	1.742985188	1.41319E-4	0.004411462
ENSG00000187164	SHTN1	1.870879701	3.15E-5	0.001300081
ENSG00000181788	SIAH2	3.03251732	1.12E-10	2.19E-8
ENSG00000088827	SIGLEC1	2.62128236	3.68E-5	0.001479302
ENSG00000147955	SIGMAR1	2.452767532	2.2E-6	1.45785E-4
ENSG00000112246	SIM1	2.916235418	2.55E-9	3.85E-7
ENSG00000197555	SIPA1L1	1.608478414	1.93665E-4	0.005713169
ENSG00000198053	SIRPA	1.786367964	9.61E-5	0.003235849
ENSG00000204351	SKIV2L	1.760019262	3.12175E-4	0.008358611
ENSG00000163950	SLBP	2.152013349	2.35E-5	0.001018241
ENSG00000064651	SLC12A2	2.116509974	1.55E-6	1.0863E-4
ENSG00000141469	SLC14A1	2.057686578	2.06017E-4	0.005985154
ENSG00000173638	SLC19A1	1.886089151	6.01E-5	0.002216211
ENSG00000135917	SLC19A3	-2.303925118	1.82E-5	8.30442E-4
ENSG00000110436	SLC1A2	-4.278571953	1.58424E-4	0.004872189
ENSG00000079215	SLC1A3	-1.999048533	2.63E-5	0.001119704
ENSG00000115902	SLC1A4	3.325969565	1.5E-15	6.28E-13
ENSG00000105281	SLC1A5	2.549097607	9.81E-9	1.26E-6
ENSG00000163393	SLC22A15	3.195666756	6.34E-5	0.002307922
ENSG00000155886	SLC24A2	9.218282286	2.23E-10	4.17E-8
ENSG00000185052	SLC24A3	2.175469205	2.74E-5	0.001155105
ENSG00000100075	SLC25A1	2.256510729	3.96E-5	0.001564102
ENSG00000177542	SLC25A22	3.002133149	1.23E-5	6.06376E-4
ENSG00000013306	SLC25A39	2.837987421	4.86E-15	1.89E-12
ENSG00000160785	SLC25A44	1.737405485	1.26E-5	6.16417E-4
ENSG00000005022	SLC25A5	1.936622185	2.13371E-4	0.006168784
ENSG00000169100	SLC25A6	2.082931221	9.12E-5	0.003101637
ENSG00000164638	SLC29A4	3.54351799	2.26E-11	5.21E-9
ENSG00000142583	SLC2A5	4.793764938	2.18E-22	2.04E-19
ENSG00000158014	SLC30A2	-4.894076834	8.18E-5	0.002834936
ENSG00000136868	SLC31A1	1.937611779	5.64E-6	3.12325E-4
ENSG00000176087	SLC35A4	2.063759806	1.48E-5	7.00037E-4
ENSG00000157593	SLC35B2	2.037186255	1.35E-5	6.54255E-4
ENSG00000181830	SLC35C1	2.337275456	2.27E-7	2.06E-5
ENSG00000213699	SLC35F6	2.871064922	3.65E-16	1.63E-13
ENSG00000111371	SLC38A1	5.000261677	1.2E-30	2.38E-27
ENSG00000188338	SLC38A3	-11.90041848	1.12422E-4	0.003677665
ENSG00000141873	SLC39A3	2.66303521	1.72E-5	7.93661E-4
ENSG00000141424	SLC39A6	2.195188012	1.62E-5	7.57341E-4
ENSG00000168003	SLC3A2	2.229381256	2.25E-6	1.47773E-4
ENSG00000138449	SLC40A1	1.921694596	2.92E-5	0.001215681
ENSG00000211584	SLC48A1	3.110940393	2.14E-15	8.87E-13
ENSG00000164889	SLC4A2	1.934337665	2.86E-5	0.001196961
ENSG00000169241	SLC50A1	1.924804716	2.21E-5	9.71382E-4
ENSG00000198743	SLC5A3	2.368007259	5.93E-6	3.26278E-4
ENSG00000139514	SLC7A1	5.756095122	9.68E-23	9.64E-20
ENSG00000130876	SLC7A10	-5.832822511	5.86E-6	3.22541E-4
ENSG00000151012	SLC7A11	5.03248416	1.25E-12	3.48E-10
ENSG00000003989	SLC7A2	2.532258218	3.22E-8	3.69E-6
ENSG00000103257	SLC7A5	6.001100638	4.19E-8	4.71E-6
ENSG00000103064	SLC7A6	-2.170742542	4.4E-5	0.001707904
ENSG00000090020	SLC9A1	2.387068541	5.38E-11	1.12E-8
ENSG00000109062	SLC9A3R1	2.167337958	1.32097E-4	0.004183749
ENSG00000137491	SLCO2B1	2.340430942	2.35E-6	1.52622E-4
ENSG00000166750	SLFN5	2.130672748	4.78E-8	5.26E-6
ENSG00000119705	SLIRP	1.828564009	1.92281E-4	0.005682869
ENSG00000250317	SMIM20	2.205317321	5.82E-5	0.002155474
ENSG00000256235	SMIM3	-177.1938289	1.17429E-4	0.003812742
ENSG00000166311	SMPD1	1.984762703	2.64786E-4	0.007335515
ENSG00000173267	SNCG	2.480708368	1.85E-5	8.40636E-4
ENSG00000260260	SNHG19	2.28919463	3.91E-5	0.001550968
ENSG00000245910	SNHG6	1.75295398	8.25E-5	0.002851725
ENSG00000161981	SNRNP25	2.351040327	9.54E-7	7.17E-5
ENSG00000077312	SNRPA	2.123325747	2.61144E-4	0.007268348
ENSG00000124562	SNRPC	2.260442035	1.56E-5	7.33045E-4
ENSG00000125743	SNRPD2	1.912601082	2.68E-6	1.68686E-4
ENSG00000139343	SNRPF	2.631241703	1.24434E-4	0.004010181
ENSG00000101400	SNTA1	2.383012632	1.28946E-4	0.004116697
ENSG00000172164	SNTB1	2.196528339	5.08E-6	2.86968E-4
ENSG00000172554	SNTG2	-6.955542784	3.46E-7	2.99E-5
ENSG00000100138	SNU13	1.800196421	4.12E-5	0.001615572
ENSG00000086300	SNX10	4.712954299	5.21E-17	2.74E-14
ENSG00000147164	SNX12	1.77428403	3.36277E-4	0.008873437
ENSG00000115234	SNX17	2.059650471	4.68E-5	0.001796587
ENSG00000143376	SNX27	1.921196013	1.5E-7	1.43E-5
ENSG00000246985	SOCS2-AS1	-2.304352803	2.4165E-4	0.00681312
ENSG00000184557	SOCS3	-8.151290341	1.56E-8	1.93E-6
ENSG00000142168	SOD1	1.776694696	2.44906E-4	0.006873116
ENSG00000095637	SORBS1	-2.488911072	3.51E-5	0.001425683
ENSG00000203883	SOX18	3.135226705	3.67E-5	0.001478278
ENSG00000110693	SOX6	-2.936953421	2.09E-6	1.39674E-4
ENSG00000125398	SOX9	3.288775108	7.87E-7	6.06E-5
ENSG00000114902	SPCS1	2.499329312	2.63E-7	2.33E-5
ENSG00000090487	SPG21	1.637534922	3.65053E-4	0.009491178
ENSG00000133710	SPINK5	7.576329402	2.44E-7	2.18E-5
ENSG00000134278	SPIRE1	1.958874308	1.71E-6	1.18444E-4
ENSG00000159674	SPON2	1.876468171	3.69769E-4	0.009593616
ENSG00000118785	SPP1	6.012965168	7.45E-10	1.28E-7
ENSG00000166068	SPRED1	1.79768564	1.42E-5	6.7965E-4
ENSG00000187678	SPRY4	1.98840569	1.03E-5	5.17086E-4
ENSG00000070182	SPTB	-2.883755597	2.29E-5	9.96864E-4
ENSG00000172296	SPTLC3	-2.226054776	2.99403E-4	0.008092704
ENSG00000134548	SPX	-4.541360005	3.0963E-4	0.008322023
ENSG00000161011	SQSTM1	3.657991654	6.52E-22	5.76E-19
ENSG00000213523	SRA1	2.107418598	3.72016E-4	0.009635492
ENSG00000145545	SRD5A1	3.132501197	8.92E-5	0.003046359
ENSG00000198911	SREBF2	2.182303976	4.48E-6	2.61052E-4
ENSG00000196935	SRGAP1	2.374416495	3.0E-11	6.72E-9
ENSG00000116649	SRM	3.308179099	8.19E-13	2.38E-10
ENSG00000248508	SRP14-AS1	-2.697157106	1.00103E-4	0.003334043
ENSG00000153037	SRP19	2.004188677	3.12E-6	1.9222E-4
ENSG00000182934	SRPRA	1.778465433	7.81E-6	4.10149E-4
ENSG00000144867	SRPRB	2.340330814	1.82E-7	1.7E-5
ENSG00000102359	SRPX2	2.034982802	1.56E-5	7.33045E-4
ENSG00000106028	SSBP1	1.812213115	3.84097E-4	0.009916357
ENSG00000180879	SSR4	2.353408366	1.58E-6	1.10199E-4
ENSG00000160075	SSU72	2.308634794	2.24E-7	2.05E-5
ENSG00000180953	ST20	2.86769066	2.33654E-4	0.006642581
ENSG00000064225	ST3GAL6	-2.431492598	2.0E-5	8.96683E-4
ENSG00000070731	ST6GALNAC2	1.989868896	4.42E-5	0.00171451
ENSG00000136840	ST6GALNAC4	4.068245506	3.99E-5	0.001575261
ENSG00000010327	STAB1	2.466431874	6.28E-8	6.7E-6
ENSG00000106610	STAG3L4	2.353136777	1.65E-5	7.66445E-4
ENSG00000136738	STAM	2.528372037	4.26E-9	6.0E-7
ENSG00000084090	STARD7	2.304230763	4.8E-8	5.26E-6
ENSG00000115415	STAT1	1.754750028	3.10068E-4	0.008329121
ENSG00000113739	STC2	4.517111929	1.88E-12	5.04E-10
ENSG00000115107	STEAP3	2.101654873	5.24E-6	2.91607E-4
ENSG00000167323	STIM1	2.487922909	1.89E-9	2.97E-7
ENSG00000168439	STIP1	2.478699152	3.37E-11	7.39E-9
ENSG00000196335	STK31	-2.569031037	3.74E-6	2.24499E-4
ENSG00000198648	STK39	3.191808164	6.75E-10	1.17E-7
ENSG00000196182	STK40	3.647254061	2.66E-17	1.55E-14
ENSG00000104435	STMN2	4.376201225	2.39E-7	2.14E-5
ENSG00000165283	STOML2	2.351486962	6.54E-6	3.53195E-4
ENSG00000243244	STON1	-2.185315334	1.32872E-4	0.004205115
ENSG00000165730	STOX1	-3.381882698	1.38E-5	6.65534E-4
ENSG00000101846	STS	1.800808594	4.07E-5	0.001598921
ENSG00000134910	STT3A	1.699829447	2.38642E-4	0.006764275
ENSG00000136854	STXBP1	2.269750003	2.6E-8	3.06E-6
ENSG00000168952	STXBP6	-3.148663367	6.73E-6	3.60702E-4
ENSG00000184900	SUMO3	1.782063212	5.34E-5	0.002005553
ENSG00000156502	SUPV3L1	2.150327161	2.35E-7	2.12E-5
ENSG00000148290	SURF1	2.426479461	7.92E-5	0.00275409
ENSG00000148291	SURF2	2.143931755	3.47306E-4	0.009109101
ENSG00000106868	SUSD1	2.940708607	3.97E-7	3.37E-5
ENSG00000157303	SUSD3	7.348026448	9.33E-5	0.003156294
ENSG00000177868	SVBP	2.570473073	2.03E-5	9.02536E-4
ENSG00000171772	SYCE1	-18.13748455	4.31E-5	0.001677441
ENSG00000108639	SYNGR2	1.991426124	2.13E-5	9.43321E-4
ENSG00000182253	SYNM	3.417884517	8.89E-17	4.47E-14
ENSG00000102003	SYP	-4.340074887	3.11226E-4	0.008341448
ENSG00000143858	SYT2	-2.409605295	1.07744E-4	0.003551376
ENSG00000142765	SYTL1	-2.608462047	3.68422E-4	0.00956836
ENSG00000055070	SZRD1	1.880551255	5.06E-5	0.001912887
ENSG00000166337	TAF10	2.052312997	4.51E-6	2.62124E-4
ENSG00000106290	TAF6	2.340859183	6.83E-5	0.002445753
ENSG00000177156	TALDO1	2.426829167	4.67E-6	2.69921E-4
ENSG00000183597	TANGO2	1.952901642	2.98406E-4	0.008070315
ENSG00000139192	TAPBPL	2.002631263	1.62554E-4	0.004960852
ENSG00000113407	TARS	2.023042451	2.15E-6	1.42963E-4
ENSG00000213977	TAX1BP3	2.978266487	6.98E-5	0.002490859
ENSG00000175463	TBC1D10C	3.114864794	3.0774E-4	0.008285218
ENSG00000107021	TBC1D13	2.030966211	3.91E-6	2.32596E-4
ENSG00000156787	TBC1D31	2.196493569	1.37E-6	9.81E-5
ENSG00000145979	TBC1D7	2.246655871	1.02884E-4	0.003414758
ENSG00000109436	TBC1D9	2.090503164	2.07E-6	1.38599E-4
ENSG00000171530	TBCA	2.894833517	2.89E-7	2.54E-5
ENSG00000105254	TBCB	2.154397428	7.64E-7	5.92E-5
ENSG00000187735	TCEA1	3.878800753	7.58E-18	4.76E-15
ENSG00000204219	TCEA3	1.985242572	5.81E-5	0.002153177
ENSG00000103363	TCEB2	2.372324728	1.71E-6	1.18444E-4
ENSG00000081059	TCF7	2.520191756	6.53E-7	5.22E-5
ENSG00000099797	TECR	2.202229899	2.28E-5	9.96864E-4
ENSG00000145934	TENM2	3.245816322	4.09E-6	2.41561E-4
ENSG00000149256	TENM4	7.566187719	3.68E-35	9.76E-32
ENSG00000107140	TESK1	2.291516098	5.63E-5	0.002094645
ENSG00000105619	TFPT	2.461118148	6.76E-5	0.002433087
ENSG00000092969	TGFB2	3.873059307	1.82E-16	8.46E-14
ENSG00000106799	TGFBR1	1.846076122	3.1306E-4	0.008376499
ENSG00000137801	THBS1	-5.887683853	2.09E-6	1.39597E-4
ENSG00000113296	THBS4	3.464325622	3.3E-11	7.26E-9
ENSG00000130193	THEM6	3.564608908	6.7E-12	1.69E-9
ENSG00000130775	THEMIS2	3.11313785	3.33E-9	4.88E-7
ENSG00000151365	THRSP	2.171377445	1.52472E-4	0.004710373
ENSG00000187720	THSD4	-5.483548134	6.0E-5	0.002214174
ENSG00000134809	TIMM10	2.495187023	9.63E-5	0.003240957
ENSG00000150779	TIMM8B	2.412236658	2.16E-5	9.52456E-4
ENSG00000102265	TIMP1	2.766388284	2.09E-8	2.49E-6
ENSG00000223573	TINCR	-4.59472885	1.64825E-4	0.005023759
ENSG00000171914	TLN2	1.923665935	7.55E-5	0.002638405
ENSG00000101916	TLR8	3.328414684	3.59E-5	0.001450279
ENSG00000139644	TMBIM6	1.839104709	9.43E-5	0.003182132
ENSG00000149488	TMC2	-3.685403642	5.17E-6	2.89484E-4
ENSG00000166557	TMED3	2.505620344	2.92E-5	0.001215681
ENSG00000251201	TMED7-TICAM2	2.635404627	2.06439E-4	0.005991621
ENSG00000241697	TMEFF1	11.54649633	7.53E-9	1.0E-6
ENSG00000184988	TMEM106A	1.831866874	1.35858E-4	0.004277318
ENSG00000152558	TMEM123	2.767407709	4.24E-9	5.99E-7
ENSG00000135956	TMEM127	2.364956462	2.55E-11	5.79E-9
ENSG00000181234	TMEM132C	-2.499738847	5.23E-5	0.001966884
ENSG00000105677	TMEM147	3.091766798	1.04E-9	1.74E-7
ENSG00000002933	TMEM176A	3.421944425	4.15E-14	1.43E-11
ENSG00000106565	TMEM176B	3.300848924	1.75E-8	2.12E-6
ENSG00000151353	TMEM18	1.714285006	1.01003E-4	0.003361688
ENSG00000198792	TMEM184B	2.298920114	6.42E-8	6.83E-6
ENSG00000240849	TMEM189	2.784078227	4.79E-9	6.69E-7
ENSG00000135048	TMEM2	-1.832545717	3.19902E-4	0.008530894
ENSG00000188807	TMEM201	4.606739671	1.47E-14	5.36E-12
ENSG00000105518	TMEM205	2.170216022	4.97E-5	0.00188415
ENSG00000187824	TMEM220	-2.582802737	2.03E-5	9.02496E-4
ENSG00000089063	TMEM230	2.070359598	2.54E-5	0.001089121
ENSG00000149582	TMEM25	-3.51814173	9.48E-5	0.003193634
ENSG00000169758	TMEM266	-3.106548507	1.57904E-4	0.004859313
ENSG00000109133	TMEM33	1.769719558	1.09E-6	8.08E-5
ENSG00000166471	TMEM41B	1.645988836	1.27132E-4	0.004078896
ENSG00000126106	TMEM53	2.101594984	1.26026E-4	0.004050572
ENSG00000155099	TMEM55A	2.33165391	3.1E-5	0.001287258
ENSG00000129925	TMEM8A	3.426623863	6.1E-9	8.3E-7
ENSG00000175348	TMEM9B	2.494499901	6.62E-11	1.34E-8
ENSG00000205542	TMSB10/TMSB4X	1.960354375	2.02E-6	1.35759E-4
ENSG00000187653	TMSB4XP8	2.231515986	1.31293E-4	0.004166571
ENSG00000213593	TMX2	2.919004872	7.06E-9	9.44E-7
ENSG00000120889	TNFRSF10B	2.380679529	8.67E-8	8.89E-6
ENSG00000006327	TNFRSF12A	8.258697006	6.86E-7	5.39E-5
ENSG00000083312	TNPO1	1.638114339	1.36351E-4	0.00429003
ENSG00000079308	TNS1	-2.36169999	4.89E-5	0.001865158
ENSG00000168477	TNXB	-2.554985624	2.05629E-4	0.005978785
ENSG00000078902	TOLLIP	1.774553583	1.28422E-4	0.004107439
ENSG00000025772	TOMM34	2.226585263	2.71197E-4	0.007469803
ENSG00000175768	TOMM5	1.776064636	1.67985E-4	0.005100534
ENSG00000131747	TOP2A	5.347398149	1.38E-6	9.85E-5
ENSG00000100038	TOP3B	2.163109587	2.6E-5	0.001108712
ENSG00000136827	TOR1A	1.979923551	2.41E-5	0.001039079
ENSG00000124191	TOX2	2.329466547	3.49E-5	0.00142001
ENSG00000141510	TP53	1.859926957	1.09308E-4	0.003585619
ENSG00000172315	TP53RK	2.272945221	3.64244E-4	0.009485643
ENSG00000134779	TPGS2	1.722680976	6.28E-5	0.002288722
ENSG00000143549	TPM3	1.87391013	3.73E-6	2.24385E-4
ENSG00000115705	TPO	-4.964831659	1.09E-5	5.42701E-4
ENSG00000166340	TPP1	2.208387287	3.35E-7	2.9E-5
ENSG00000197253	TPSAB1/TPSB2	3.948104367	1.1E-8	1.4E-6
ENSG00000128294	TPST2	3.902695293	8.62E-14	2.88E-11
ENSG00000186854	TRABD2A	-2.864463376	1.38E-7	1.32E-5
ENSG00000131323	TRAF3	2.36283228	1.42E-10	2.72E-8
ENSG00000170043	TRAPPC1	2.402064529	5.62E-5	0.002094645
ENSG00000181029	TRAPPC5	2.905907695	3.54E-6	2.14769E-4
ENSG00000007255	TRAPPC6A	2.479271989	9.65E-6	4.89402E-4
ENSG00000211829	TRDC	-4.381110081	2.81E-6	1.7571E-4
ENSG00000095970	TREM2	4.893474874	6.6E-5	0.002385991
ENSG00000101255	TRIB3	13.1395273	6.3E-79	1.0E-74
ENSG00000221926	TRIM16	2.083930504	1.51E-5	7.13029E-4
ENSG00000130726	TRIM28	2.418494965	3.37E-7	2.92E-5
ENSG00000204616	TRIM31	-21.48702981	3.51913E-4	0.009209716
ENSG00000147573	TRIM55	-12.2299171	4.12E-8	4.66E-6
ENSG00000100106	TRIOBP	2.084865491	2.09E-7	1.91E-5
ENSG00000174173	TRMT10C	2.317999118	8.74E-5	0.002990242
ENSG00000173113	TRMT112	2.142676228	3.19E-6	1.96626E-4
ENSG00000104321	TRPA1	3.712714417	1.23E-8	1.55E-6
ENSG00000119121	TRPM6	-3.144382013	3.14186E-4	0.008397581
ENSG00000167112	TRUB2	2.095224586	1.14E-5	5.65798E-4
ENSG00000196428	TSC22D2	2.004822527	2.52E-5	0.001080764
ENSG00000135951	TSGA10	-3.944623058	2.47E-5	0.001061176
ENSG00000211460	TSN	1.832827123	7.34E-5	0.002589066
ENSG00000158457	TSPAN33	3.493795898	9.29E-5	0.003146431
ENSG00000100300	TSPO	2.19098035	8.38E-6	4.32484E-4
ENSG00000180543	TSPYL5	1.894591752	1.18396E-4	0.003841516
ENSG00000007520	TSR3	2.622801792	3.63E-9	5.27E-7
ENSG00000139908	TSSK4	-3.227320206	2.61834E-4	0.007278709
ENSG00000215845	TSTD1	-2.755183755	7.31E-6	3.87327E-4
ENSG00000113312	TTC1	1.771199855	3.47915E-4	0.009120061
ENSG00000103852	TTC23	1.975324233	4.94E-7	4.11E-5
ENSG00000114999	TTL	1.96394349	4.37E-5	0.001698631
ENSG00000136295	TTYH3	3.032543836	3.04E-10	5.55E-8
ENSG00000166402	TUB	3.926859841	6.99E-15	2.69E-12
ENSG00000123416	TUBA1B	1.873933497	7.19E-5	0.002554245
ENSG00000167553	TUBA1C	3.44631026	3.84E-11	8.26E-9
ENSG00000196230	TUBB	1.902355524	5.86E-5	0.002166637
ENSG00000137267	TUBB2A	3.268995896	1.62E-13	5.15E-11
ENSG00000188229	TUBB4B	2.424609968	7.35E-7	5.71E-5
ENSG00000131462	TUBG1	1.973204769	9.78E-5	0.003285892
ENSG00000078246	TULP3	1.653833043	3.60537E-4	0.009404485
ENSG00000136810	TXN	3.438800372	2.6E-20	1.97E-17
ENSG00000117862	TXNDC12	3.147183661	3.01E-16	1.35E-13
ENSG00000091164	TXNL1	1.654686051	1.54E-5	7.25334E-4
ENSG00000141759	TXNL4A	2.135972301	2.8197E-4	0.007702586
ENSG00000198431	TXNRD1	2.817241577	3.07E-13	9.35E-11
ENSG00000025708	TYMP	2.153095205	2.65E-5	0.001127807
ENSG00000011600	TYROBP	4.392370328	2.05E-14	7.25E-12
ENSG00000130985	UBA1	1.76835278	9.71E-5	0.003264853
ENSG00000126261	UBA2	1.716557216	1.62013E-4	0.004950676
ENSG00000221983	UBA52	1.931633468	2.25E-5	9.85898E-4
ENSG00000033178	UBA6	1.846438105	9.91E-5	0.003318977
ENSG00000185262	UBALD2	2.392660525	6.58E-6	3.54861E-4
ENSG00000077721	UBE2A	1.981602175	8.03E-6	4.18569E-4
ENSG00000131508	UBE2D2	2.064555209	1.69E-6	1.17203E-4
ENSG00000109332	UBE2D3	1.685795054	2.10933E-4	0.006101979
ENSG00000170142	UBE2E1	2.132920844	1.11775E-4	0.003661498
ENSG00000182247	UBE2E2	2.177223923	9.47E-6	4.80802E-4
ENSG00000132388	UBE2G1	1.803931239	1.32E-5	6.429E-4
ENSG00000103275	UBE2I	1.726498597	1.77228E-4	0.005310295
ENSG00000160087	UBE2J2	2.147954716	1.69515E-4	0.005133933
ENSG00000078140	UBE2K	2.13591494	2.43E-6	1.56049E-4
ENSG00000198258	UBL5	1.838114203	6.33E-5	0.002303819
ENSG00000135018	UBQLN1	1.928687202	1.94E-5	8.74375E-4
ENSG00000162191	UBXN1	2.008983212	7.28E-5	0.002578193
ENSG00000167671	UBXN6	2.289354262	1.11E-5	5.54097E-4
ENSG00000154277	UCHL1	6.65411393	2.34E-35	6.99E-32
ENSG00000130717	UCK1	2.576284557	1.84E-6	1.26627E-4
ENSG00000175567	UCP2	2.778009253	3.37E-6	2.07069E-4
ENSG00000111647	UHRF1BP1L	1.817433384	1.34804E-4	0.004253607
ENSG00000107731	UNC5B	13.68073362	3.29E-83	7.86E-79
ENSG00000076248	UNG	2.527999807	6.07E-7	4.9E-5
ENSG00000137288	UQCC2	5.860540056	6.69E-17	3.47E-14
ENSG00000184076	UQCR10	2.403910566	1.20758E-4	0.003907548
ENSG00000127540	UQCR11	2.292607356	8.2E-5	0.002837168
ENSG00000164405	UQCRQ	2.66199804	9.11E-8	9.3E-6
ENSG00000142207	URB1	2.164092143	2.54E-8	3.0E-6
ENSG00000256073	URB1-AS1	3.656505142	7.62E-5	0.002660823
ENSG00000188690	UROS	3.615261117	4.1E-12	1.06E-9
ENSG00000173915	USMG5	2.171535305	6.62E-6	3.56285E-4
ENSG00000124422	USP22	1.85859839	2.61E-5	0.001116004
ENSG00000109189	USP46	2.003882407	1.27164E-4	0.004078896
ENSG00000111667	USP5	2.174559976	2.86E-6	1.78726E-4
ENSG00000164338	UTP15	2.140247896	1.45E-5	6.92325E-4
ENSG00000011260	UTP18	2.559439561	3.31E-5	0.001354345
ENSG00000141076	UTP4	1.696700526	8.16E-5	0.002830972
ENSG00000115652	UXS1	2.216700386	9.44E-6	4.7977E-4
ENSG00000103043	VAC14	2.489732338	1.09E-9	1.82E-7
ENSG00000118640	VAMP8	3.930947647	4.99E-9	6.95E-7
ENSG00000173218	VANGL1	2.376086337	1.19E-6	8.7E-5
ENSG00000101558	VAPA	2.376899638	3.68E-10	6.6E-8
ENSG00000108828	VAT1	2.684646117	1.76E-11	4.13E-9
ENSG00000162692	VCAM1	2.373712944	6.93E-5	0.002478017
ENSG00000165280	VCP	1.683330226	3.0601E-4	0.008247945
ENSG00000213585	VDAC1	2.033385968	8.1E-7	6.22E-5
ENSG00000205221	VIT	-2.650212034	2.16129E-4	0.006229801
ENSG00000160695	VPS11	1.644133825	1.44468E-4	0.004495083
ENSG00000155659	VSIG4	3.346083817	8.52E-9	1.11E-6
ENSG00000140105	WARS	3.536861349	1.74E-17	1.05E-14
ENSG00000132471	WBP2	2.002405575	1.02E-5	5.14303E-4
ENSG00000134987	WDR36	2.021335442	2.4E-5	0.001036435
ENSG00000109685	WHSC1	1.814906678	4.33E-6	2.54089E-4
ENSG00000111186	WNT5B	3.275220651	1.13199E-4	0.003698007
ENSG00000109046	WSB1	2.083357417	1.04E-8	1.33E-6
ENSG00000176871	WSB2	3.080234097	3.54E-15	1.4E-12
ENSG00000122121	XPNPEP2	3.400519137	2.38E-11	5.43E-9
ENSG00000132953	XPO4	1.848925222	1.73551E-4	0.005232944
ENSG00000124571	XPO5	1.68864342	3.28417E-4	0.008704502
ENSG00000169180	XPO6	1.977960133	1.18E-5	5.83058E-4
ENSG00000184575	XPOT	4.071933239	1.87E-31	4.25E-28
ENSG00000103489	XYLT1	2.517336961	2.15E-9	3.32E-7
ENSG00000134684	YARS	2.298821324	2.72E-9	4.08E-7
ENSG00000130733	YIPF2	2.690783551	6.98E-7	5.48E-5
ENSG00000170027	YWHAG	2.087373004	7.9E-6	4.13928E-4
ENSG00000128245	YWHAH	1.835062399	5.61E-5	0.002089928
ENSG00000247271	ZBED5-AS1	2.121659033	2.56416E-4	0.007145101
ENSG00000109906	ZBTB16	-3.910670457	1.13E-6	8.29E-5
ENSG00000160685	ZBTB7B	2.897711446	3.95E-9	5.66E-7
ENSG00000158552	ZFAND2B	2.189259676	7.28E-6	3.86447E-4
ENSG00000156639	ZFAND3	2.722773826	6.42E-12	1.63E-9
ENSG00000177410	ZFAS1	2.653993132	3.85E-7	3.28E-5
ENSG00000152926	ZNF117	3.284351141	1.31E-15	5.58E-13
ENSG00000165804	ZNF219	2.121189701	1.47E-5	6.99074E-4
ENSG00000109445	ZNF330	2.36372295	5.66E-9	7.79E-7
ENSG00000198816	ZNF358	2.479301696	2.27E-5	9.92657E-4
ENSG00000173258	ZNF483	-2.128533369	1.81615E-4	0.005414551
ENSG00000198546	ZNF511	2.089800787	6.62E-5	0.002389208
ENSG00000233527	ZNF529-AS1	3.408058417	2.98253E-4	0.008070315
ENSG00000102870	ZNF629	1.875040785	4.8E-5	0.001834409
ENSG00000171161	ZNF672	2.239135618	4.96E-5	0.001881089
ENSG00000198429	ZNF69	-3.897124833	7.87E-5	0.002740586
ENSG00000151612	ZNF827	1.863480507	2.35E-5	0.001018241
ENSG00000167232	ZNF91	1.75647262	1.07394E-4	0.003542282
ENSG00000183579	ZNRF3	1.8697069	2.95095E-4	0.008007977

