Figure 4 - Source Data 3 Data related to Parameter Recovery of M2 Saline/CNO sessions. __________________________________________________________________________________________________________ Model 1, Stable Period, Original ¦Á1 (each row contains data from one animal) Saline CNO 0.124011535494523 0.0882580330520658 -0.0372296819293979 -0.0127197877743288 -0.0700768342637919 -0.103316713302463 -0.342059804731515 0.0861816203720035 -0.176203381244838 -0.254749677492638 -0.0599689132153718 -0.17659604215661 -0.169885506234495 -0.21740949692171 0.250360007162715 -0.0439526848590363 -0.248427850331396 -0.489196425524063 0.175827300750654 0.194476085738256 Model 1, Stable Period, Recovered ¦Á1 (each row contains data from one animal) Saline CNO 0.0586766460027124 0.0884690496041964 -0.238461664143056 0.205201396583467 -0.23562120139909 -0.0253626923393303 -0.431183371760821 0.322345537265004 -0.224991753868861 -0.319179234349694 -0.060082293321504 -0.169013816262731 -0.345017476887717 -0.241716300480969 0.303616135609774 -0.223479055727786 -0.138622415088091 -0.567013593652775 0.533234516492997 0.368858115860849 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value >0.9999 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 28 , -27 Sum of signed ranks (W) 1 Number of pairs 10 Median of differences Median -0.0322 How effective was the pairing? rs (Spearman) 0.04242 P value (one tailed) 0.4592 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Stable Period, Original ¦Á2 (each row contains data from one animal) Saline CNO 0.110684281047128 0.339946099060691 0.642696577549826 0.267315399350623 0.534395063550903 0.588958343078407 0.2624921068174 -0.0886315220533671 0.278085907838804 0.547414344404993 0.123044668474944 0.0351059717545136 0.240901039820901 0.0994427132310118 1.43980863447452 0.687528209183159 0.497208065469504 0.327709905062739 0.911874994642401 0.472188366642316 Model 1, Stable Period, Recovered ¦Á2 (each row contains data from one animal) Saline CNO 0.0161006442267934 0.281341277718417 0.605727456268564 0.440272143153016 0.23018662318498 0.587723991984493 0.39243727340431 -0.144241344275213 0.112215742936755 0.543043873426372 0.0312534591102571 0.0091693054852392 0.0175604039440626 0.231863657664199 1.49405682318654 0.46083675973318 0.637225409739688 0.468053379928568 1.34864502484637 0.456770714524352 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.6250 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 22 , -33 Sum of signed ranks (W) -11 Number of pairs 10 Median of differences Median -0.09377 How effective was the pairing? rs (Spearman) 0.3455 P value (one tailed) 0.1652 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Stable Period, Original ¦Â (each row contains data from one animal) Saline CNO 0.0259173521321527 0.0313807698908039 0.0899968994886314 0.126254771244048 0.000544528763968269 0.186484502961658 0.0383506282314232 0.160521226536869 0.117626589814614 0.118411102245732 -0.0325094807809639 -0.109802346562105 0.181950433085434 -0.0466716458572466 0.14350276764387 0.0926667599576332 0.242215986956862 0.203288900220987 0.175155978732152 0.517330812912658 Model 1, Stable Period, Recovered ¦Â (each row contains data from one animal) Saline CNO 0.0404150590846909 -0.00465215984041882 0.0746181653725117 0.234278345459084 -0.0465507428042632 0.15279913067485 0.0644886308386184 0.255505104106267 0.119330164499078 0.0838089076723346 -0.0282930940790967 -0.115788353270651 0.163364553728559 -0.0507481773475853 0.1271317814606 0.0769094237325474 0.290430962677335 0.173356041652559 0.224005596659086 0.553740926983851 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.7695 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 31 , -24 Sum of signed ranks (W) 7 Number of pairs 10 Median of differences Median -0.04029 How effective was the pairing? rs (Spearman) 0.297 P value (one tailed) 0.2035 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Stable Period, Original ¦Ã1 (each row contains data from one animal) Saline CNO 3.24690416891015 3.60406692100054 3.66041125913051 3.47903627808908 4.25369058827115 4.21069101264995 6.03126738783521 3.85211649602861 5.43672406206582 4.7560375278073 4.90176089642235 3.78036659727862 4.24352574587797 4.74756515403122 6.08977233633978 5.15713368770663 4.54627288938741 4.37610379314409 4.47621297330754 3.47050410655507 Model 1, Stable Period, Recovered ¦Ã1 (each row contains data from one animal) Saline CNO 3.2020121207792 3.5361488569109 3.49894912664721 3.60343915499963 3.86951071849288 4.63826920165837 6.39425326771952 4.17727663668052 4.74899460298289 4.84736331405988 4.98389657451831 3.48663505999233 4.12233710265322 5.13470243125055 6.15238376066056 4.88646201981146 4.86083213739852 4.57192054927873 4.71918910019618 3.48796412018971 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.3750 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 18 , -37 Sum of signed ranks (W) -19 Number of pairs 10 Median of differences Median -0.09527 How effective was the pairing? rs (Spearman) 0.103 P value (one tailed) 0.3925 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Stable Period, Original ¦Ã2 (each row contains data from one animal) Saline CNO 0.144171126322482 0.126438171033563 0.413519422073084 0.388508924405434 0.125988701366347 0.654298878050862 0.353556372637152 0.427294885939811 0.713605750419951 0.555772304029654 0.0706561962928921 -0.0160697818954269 0.709902346939906 0.21678646510307 0.351814960735116 0.395220870387911 0.887777958981945 0.969166790881458 0.388408003814219 1.06927407364315 Model 1, Stable Period, Recovered ¦Ã2 (each row contains data from one animal) Saline CNO 0.248758046788362 0.0728502853551994 0.481994523177601 0.537059326584108 0.145756122908474 0.612926548233592 0.429783870670815 0.617843680161356 0.65535889327625 0.505091423026741 0.115079440895091 -0.0464873019897219 0.820642825157288 0.240180552443493 0.174235181637261 0.508748638759706 0.994852723872542 0.899686197040451 0.265996069764659 1.06998742236369 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.6953 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 32 , -23 Sum of signed ranks (W) 9 Number of pairs 10 Median of differences Median -0.02005 How effective was the pairing? rs (Spearman) 0.297 P value (one tailed) 0.2035 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Switching Period, Original ¦Á1 (each row contains data from one animal) Saline CNO 0.00321662045984871 0.473746885637034 -0.194720416852104 0.47537244714394 -0.198040995886694 -0.176571998086992 -0.0222514808660019 0.608810961109263 -0.580422505281754 -0.0877404220933709 -0.409863574265644 0.339290395798091 -0.148774445794279 -0.322272093642966 0.130014805343776 -0.419166837455136 -0.323110613284268 0.124503812615201 -0.07198896900855 0.412278055306911 Model 1, Stable Period, Recovered ¦Á1 (each row contains data from one animal) Saline CNO -0.0527951517160554 0.695586877412237 -0.374128146957773 0.410332190663613 -0.209468800047606 -0.236915192138232 -0.183063815596735 0.633368549094944 -0.668743286222666 -0.169055371001202 -0.306656071197538 0.398668567095501 -0.134713774864437 -0.316753869721157 0.159066320551342 -0.272686559599117 -0.384646755262253 0.150408957489383 -0.125075044285551 0.449629901111691 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.0273 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 49 , -6 Sum of signed ranks (W) 43 Number of pairs 10 Median of differences Median 0.5549 How effective was the pairing? rs (Spearman) 0.07879 P value (one tailed) 0.4191 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Switching Period, Original ¦Á2 (each row contains data from one animal) Saline CNO -0.0696169562060661 -0.0953475054318384 0.0370755732265046 0.087769472537396 0.111378706706415 -0.0567237725501658 0.206008435280993 -0.283890334746834 0.326364086826093 0.045548973094767 -0.0696998286643916 -0.432299297417586 0.250897760704755 0.122813201086138 -0.0109180518862347 -0.172251179566556 0.0813059637365103 -0.137134897463986 -0.0279090961329138 0.205020171231458 Model 1, Switching Period, Recovered ¦Á2 (each row contains data from one animal) Saline CNO -0.0454140007232223 -0.293035889561467 0.0101455230045542 0.0883452526333258 0.0665877318433626 -0.290365551187502 0.218417127692991 -0.165226599487421 0.299076180048378 0.0654770316513712 0.138908784473926 -0.643164458375981 0.0942191474126961 -0.0246564682414749 -0.115344329590538 -0.120533313602994 0.186192589367539 0.0124583635124907 0.0472567044371112 0.200703328922949 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.0273 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 6 , -49 Sum of signed ranks (W) -43 Number of pairs 10 Median of differences Median -0.2037 How effective was the pairing? rs (Spearman) 0.04242 P value (one tailed) 0.4592 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 1, Switching Period, Original ¦Â (each row contains data from one animal) Saline CNO 0.330257821686115 0.214432142219459 0.525476033846273 0.0194352727823235 0.0999661963167093 0.271446215985743 0.383404764233356 0.208609314984256 0.360335186360722 0.520998434050106 0.542362971685511 0.317560010314057 0.193164611110143 0.863075447100547 0.269680747357678 0.335820280365474 0.393982202577919 0.250939064678467 0.70043288919399 0.079663690398402 Model 1, Switching Period, Recovered ¦Â (each row contains data from one animal) Saline CNO 0.312492607205369 0.323739900178192 0.610884451463508 0.00759954726830076 0.0817309546112869 0.396000564543027 0.442597435322436 0.159355241091172 0.32327726440566 0.596210926043171 0.412768433336913 0.420664183261051 0.24993294776695 0.911666263913284 0.256521283684994 0.224211778767246 0.354669402255517 0.15649510470616 0.605229534145132 0.154072858232689 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.8457 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 25 , -30 Sum of signed ranks (W) -5 Number of pairs 10 Median of differences Median -0.01221 How effective was the pairing? rs (Spearman) -0.697 P value (one tailed) 0.0153 P value summary * Was the pairing significantly effective? Yes __________________________________________________________________________________________________________ Model 1, Switching Period, Original ¦Ã1 (each row contains data from one animal) Saline CNO 2.32080638058374 3.27327165970913 2.69881466168548 2.31593650196742 3.64058426401931 3.79798566519693 19.1402548771174 4.21081071433224 4.45557590996107 4.63255401052534 3.32715966687445 3.81451365716401 3.55118008156477 3.69037819095125 4.24596113870077 3.50725672881655 5.08250117073672 4.82479965635305 3.55876580848129 2.76824286917258 Model 1, Switching Period, Recovered ¦Ã1 (each row contains data from one animal) Saline CNO 2.262178306873 2.99675507805299 2.77834377609463 2.26886740404993 3.37040336499171 3.78195240204795 44.979846787288 4.14002965417012 5.39984960219393 4.67793242510625 3.67876570216006 3.95755966458632 3.37810093089368 3.67825222397415 4.76503560960303 3.34225628565172 5.05986288962705 4.43310762038782 3.69676200821453 2.5842740567204 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.1602 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 13 , -42 Sum of signed ranks (W) -29 Number of pairs 10 Median of differences Median -0.5681 How effective was the pairing? rs (Spearman) 0.697 P value (one tailed) 0.0153 P value summary * Was the pairing significantly effective? Yes __________________________________________________________________________________________________________ Model 1, Switching Period, Original ¦Ã2 (each row contains data from one animal) Saline CNO 0.230170646236604 -0.0771876660028076 0.235299697685787 -0.060064663602492 0.36662957254931 0.384830286811676 0.353648126572062 0.238169269779896 0.815755192911634 0.605179417624465 0.516319914131133 0.453547702505427 0.394399147292527 0.0990844299283567 0.361991341763237 0.524095942210315 0.790063164674324 0.323880076993866 0.57995320516707 -0.0113429267758801 Model 1, Switching Period, Recovered ¦Ã2 (each row contains data from one animal) Saline CNO 0.22858408250475 -0.174637841508911 0.273545201169646 -0.0511328506623792 0.396008721275054 0.321821272196939 0.3582409367576 0.206151354698692 0.904568901248758 0.648005805207508 0.398224258832912 0.521824291781384 0.560809151431876 0.0526708389586367 0.383227381281573 0.502348641820676 0.600765020830837 0.243534961860081 0.362968390459704 -0.0377222331319012 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.0195 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 5 , -50 Sum of signed ranks (W) -45 Number of pairs 10 Median of differences Median -0.2906 How effective was the pairing? rs (Spearman) 0.7333 P value (one tailed) 0.0101 P value summary * Was the pairing significantly effective? Yes __________________________________________________________________________________________________________ Model 4, Stable Period, Original ¦Â (each row contains data from one animal) Saline CNO -0.014292855431624 -0.0217818448263881 -0.000204661117426931 0.120584767494944 0.0317668742057153 0.165115741746776 0.104387746330424 0.10895499324449 0.139556409967649 0.144537046358729 -0.028606149857221 -0.0596049874056697 0.213461357611906 0.00217310216467111 0.0305283362020176 0.0881986468254487 0.276817273994284 0.306876424290878 -0.0631685966477347 0.294182828173887 Model 4, Stable Period, Recovered ¦Â (each row contains data from one animal) Saline CNO -0.0265241626382002 -0.0450007914733804 -0.0429423364515014 0.0974950898971312 0.0476425827067412 0.0757312538064557 0.0744657015668736 0.0783893114659276 0.140819556968162 0.114304240474178 -0.0713332557856558 -0.000231824370584451 0.223070272413054 0.0332381543953066 -0.0102590624235361 0.0455557138010376 0.201778637239882 0.328922796563272 -0.0954423145017287 0.24644013317723 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.1934 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 41 , -14 Sum of signed ranks (W) 27 Number of pairs 10 Median of differences Median 0.04195 How effective was the pairing? rs (Spearman) 0.1394 P value (one tailed) 0.3536 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 4, Stable Period, Original ¦Ã1 (each row contains data from one animal) Saline CNO 3.20223859806431 3.50735564735495 3.5627237796377 3.45230197275101 4.09786618937082 4.1441119755265 5.6408051401855 3.868504731065 5.49398119529064 4.73734013431476 4.93336154989992 3.76775531050624 4.29584283953871 4.77146184934297 5.71880841797551 4.97077709304055 4.45207393498481 4.41789166040431 4.41581856270468 3.39935957366892 Model 4, Stable Period, Recovered ¦Ã1 (each row contains data from one animal) Saline CNO 3.25872567008654 3.50182938232519 3.47683861535941 3.73773791548049 3.94397052879427 3.82497702175733 5.47052257840031 4.05065553099437 5.23832459292957 4.74164179913149 4.78729502268988 3.67213251520523 4.07152463112295 4.55165473252867 5.87669885759582 5.07003799220094 4.19447591401877 4.21047313849537 4.42325716496095 3.22770896259458 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.1602 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 13 , -42 Sum of signed ranks (W) -29 Number of pairs 10 Median of differences Median -0.3078 How effective was the pairing? rs (Spearman) 0.5152 P value (one tailed) 0.0667 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 4, Stable Period, Original ¦Ã2 (each row contains data from one animal) Saline CNO 0.119687212458853 0.0972717709777323 0.191893419967344 0.408899272017408 0.226334817864095 0.634938615422925 0.323280962235916 0.351671060363023 0.701532800995365 0.553217837202953 0.0688818432621254 -0.00418113211408358 0.731996411228658 0.214193644908207 0.307582235294938 0.424678100078131 0.883200235558981 0.992688956889821 -0.0278862219574442 0.772917629457168 Model 4, Stable Period, Recovered ¦Ã2 (each row contains data from one animal) Saline CNO 0.103423722818881 0.0775973949675808 0.0641563048803412 0.361849550579526 0.227761038582891 0.338199502418922 0.223341086236418 0.30678639265567 0.764118945708607 0.486722375288813 -0.0322790666456123 0.14577913867869 0.784724045837393 0.266860894090115 0.264143902895958 0.309284832842643 0.716745786542317 1.00876826051809 -0.0923499691943267 0.560084263399274 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.2754 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 39 , -16 Sum of signed ranks (W) 23 Number of pairs 10 Median of differences Median 0.09694 How effective was the pairing? rs (Spearman) 0.103 P value (one tailed) 0.3925 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 4, Switching Period, Original ¦Â (each row contains data from one animal) Saline CNO 0.331562954055761 0.288448329723164 0.393383201756877 0.220388512815913 0.0883893526975968 0.254035876408533 0.463813260518781 0.32091992117355 0.483940322155214 0.52311311310617 0.420682805953626 0.438201083912891 0.196275796677017 0.842767554644432 0.25934167054873 0.241578880159728 0.263971533083279 0.294333115838423 0.714865320660248 0.274431548132954 Model 4, Switching Period, Recovered ¦Â (each row contains data from one animal) Saline CNO 0.298129472135127 0.322173165021853 0.32111407296995 0.137892759071892 0.0496835311776917 0.322637732387537 0.436417539869731 0.316663764134666 0.401270825487822 0.498848512018766 0.408199628900966 0.506288298469498 0.230809698183185 0.717123161377135 0.242999033228937 0.230186830530616 0.253713061948342 0.317773446875919 0.792143177365853 0.315143868128642 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.6953 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 32 , -23 Sum of signed ranks (W) 9 Number of pairs 10 Median of differences Median 0.04405 How effective was the pairing? rs (Spearman) -0.2364 P value (one tailed) 0.2567 P value summary ns Was the pairing significantly effective? No __________________________________________________________________________________________________________ Model 4, Switching Period, Original ¦Ã1 (each row contains data from one animal) Saline CNO 2.35001860656359 3.02962737459407 2.7467305043704 1.99085376798909 3.65211609526906 3.85967279916645 19.3259296159127 3.85159796225348 4.48945968415752 4.67000173221326 3.45041322250781 3.66869271660154 3.47891621806338 3.76246413410528 4.18183025799746 3.66725296957953 5.09788511459998 4.77824861111382 3.5945959669676 2.50791736346732 Model 4, Switching Period, Recovered ¦Ã1 (each row contains data from one animal) Saline CNO 2.28889643003468 3.00249788927481 2.77806075949799 1.76158292548946 3.89404723688178 4.1255162303511 37.8009569873357 4.34071760748619 5.10154375898714 5.01885881515181 3.44553414909979 3.81464892066238 3.1294061791007 4.38278865250352 4.25609616775707 3.51892341146167 5.15032717316959 4.77894987999366 3.68678212725579 2.60007541617747 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.4316 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 19 , -36 Sum of signed ranks (W) -17 Number of pairs 10 Median of differences Median -0.227 How effective was the pairing? rs (Spearman) 0.6242 P value (one tailed) 0.0302 P value summary * Was the pairing significantly effective? Yes __________________________________________________________________________________________________________ Model 4, Switching Period, Original ¦Ã2 (each row contains data from one animal) Saline CNO 0.206528465819321 -0.0221797637530381 0.202474149663467 -0.0399806696756066 0.342409166243662 0.298600826774075 0.438051909265542 0.453933793992928 0.783792714012463 0.607051335179124 0.349242353432389 0.459076630165137 0.391045398886974 0.092573324361141 0.414180276659953 0.298845489327744 0.547848633680939 0.315123197978425 0.558860956789496 0.226479324098977 Model 4, Switching Period, Recovered ¦Ã2 (each row contains data from one animal) Saline CNO 0.210535790847519 -0.163769515315623 0.229209273654258 0.067419243564818 0.408430172771268 0.387224728021515 0.429756190597444 0.510287436270999 0.820440920617093 0.712594001147673 0.352420194852669 0.516310969145346 0.332565828888173 0.165682509987041 0.38334890976858 0.243780302731095 0.521896218154377 0.273439041918809 0.629187480413301 0.107835215193006 _____________________________________ Test results for Recovered Parameters Column B CNO vs. vs. Column A Saline Wilcoxon matched-pairs signed rank test P value 0.0488 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 8 , -47 Sum of signed ranks (W) -39 Number of pairs 10 Median of differences Median -0.1507 How effective was the pairing? rs (Spearman) 0.5879 P value (one tailed) 0.0403 P value summary * Was the pairing significantly effective? Yes