Figure 5 - Source Data 2 Behavior data of mice used in M2 recording. _____________________________________________________________________________________________ Average right choice bias of sensory history, for recording mice (each row contains data from one animal) Switching-PrevLow Switching-PrevHigh Stable-PrevLow Stable-PrevHigh 20.0157740843336 -16.2037037037037 10.3571428571429 -4.86275290545753 17.051282051282 -17.8531345198012 1.93761542012928 -8.01169590643275 10.4060913705584 -15.8000896458987 9.32951653944021 -10.642481275643 7.3764705882353 -18.6571319205206 4.72885423591315 -5.7222386442014 15.4509447192374 -12.5382566874677 4.63810184893039 -2.8799291094373 2.70853084973881 -11.5313991920676 5.86858123926956 -2.51349527665317 13.6894586894587 -14.9792927683976 4.45742022299116 -5.24411106724569 7.79206322702733 -13.7284537047033 7.2979164394022 -6.91489361702128 12.6458984053921 -8.47630718954248 4.28711897738447 -2.04288064131894 19.139797834512 -19.972972972973 8.94062078272604 -8.20423598201376 11.4190356993861 -16.8155636534619 7.13489409141583 -7.47731397459165 ______________________________ Test results for stable period Column D Stable-PreHigh vs. vs. Column C Stable-PreLow Wilcoxon matched-pairs signed rank test P value 0.0010 Exact or approximate P value? Exact P value summary *** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 0 , -66 Sum of signed ranks (W) -66 Number of pairs 11 Median of differences Median -10.45 How effective was the pairing? rs (Spearman) -0.3636 P value (one tailed) 0.1365 P value summary ns Was the pairing significantly effective? No ______________________________ Test results for switching period Column B Switching-PreHigh vs. vs. Column A Switching-PreLow Wilcoxon matched-pairs signed rank test P value 0.0010 Exact or approximate P value? Exact P value summary *** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 0 , -66 Sum of signed ranks (W) -66 Number of pairs 11 Median of differences Median -27.99 How effective was the pairing? rs (Spearman) -0.3182 P value (one tailed) 0.1708 P value summary ns Was the pairing significantly effective? No _______________________________________________________________________________________________________________________________________________________________________________________ Cross-validated model likelihood during stable period (each data is the median value of corresponding likelihood distribution, each row contains data from one animal) Model 1 (full model) Model 2 (¦Á1 = 0) Model 3 (¦Á2 = 0) Model 4 (¦Á1 = 0, ¦Á2 = 0) Model 5 (¦Â = 0) Model 6 (¦Ã1 = 1) Model 7 (¦Ã2 = 0) RL Model 0.739429029962216 0.734321281455853 0.739005184487934 0.741719791039647 0.729598864939238 0.587831867424493 0.729372877265116 0.726424142200923 0.72236141014984 0.727367481615822 0.763653241914763 0.764315411321725 0.725551731880954 0.593435667818733 0.728333157927748 0.765096916171858 0.732512297040007 0.724815360333547 0.722428772713408 0.729298255579025 0.724326639617947 0.561979725932184 0.719363550617334 0.721031909263374 0.775037806030952 0.769914935872849 0.785770374538387 0.788155516260155 0.785289767454618 0.579195276253117 0.780276225636934 0.776675169227359 0.688134185922274 0.675847937920585 0.689951986679447 0.693499882474334 0.691914837991066 0.593719923457735 0.687430249185128 0.691506724526077 0.585514639565124 0.590962331516926 0.626117190354407 0.623576387768546 0.622875090275554 0.588723485735315 0.626576977782648 0.625697788379023 0.757309865918113 0.761263935345475 0.754989861762264 0.756612174354271 0.753284790249282 0.533750193607506 0.746998945515973 0.756277127756769 0.753860873999575 0.746761280188609 0.759030530499093 0.766303167458202 0.761734788935221 0.583680022513664 0.753550278776294 0.752174808501138 0.736615643654392 0.726412965804674 0.763636028482061 0.765405378428302 0.748571359986766 0.56976505196164 0.748183343122157 0.767446889989156 0.720880583942957 0.71360753496805 0.735014124189803 0.74014084316428 0.730785614507137 0.604665782003432 0.732943386450914 0.732264237623521 0.785962929024967 0.778682767345621 0.782670534116025 0.785231552680957 0.780980377085755 0.530602644508397 0.777688759699804 0.779733717321811 ___________________________________ Test results for Model 2 vs Model 1 Column B Model 2 (¦Á1 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0244 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 8 , -58 Sum of signed ranks (W) -50 Number of pairs 11 Median of differences Median -0.0071 How effective was the pairing? rs (Spearman) 0.9727 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 3 vs Model 1 Column C Model 3 (¦Á2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.1016 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 52 , -14 Sum of signed ranks (W) 38 Number of pairs 11 Median of differences Median 0.00517 How effective was the pairing? rs (Spearman) 0.7727 P value (one tailed) 0.0037 P value summary ** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 4 vs Model 1 Column D Model 4 (¦Á1 = 0, ¦Á2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0186 Exact or approximate P value? Exact P value summary * Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 59 , -7 Sum of signed ranks (W) 52 Number of pairs 11 Median of differences Median 0.01244 How effective was the pairing? rs (Spearman) 0.8455 P value (one tailed) 0.0009 P value summary *** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 5 vs Model 1 Column E Model 5 (¦Â = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.2783 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 46 , -20 Sum of signed ranks (W) 26 Number of pairs 11 Median of differences Median 0.003781 How effective was the pairing? rs (Spearman) 0.9 P value (one tailed) 0.0002 P value summary *** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 6 vs Model 1 Column F Model 6 (¦Ã1 = 1) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0020 Exact or approximate P value? Exact P value summary ** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 1 , -65 Sum of signed ranks (W) -64 Number of pairs 11 Median of differences Median -0.1669 How effective was the pairing? rs (Spearman) -0.7636 P value (one tailed) 0.0043 P value summary ** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 7 vs Model 1 Column G Model 7 (¦Ã2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.8984 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 35 , -31 Sum of signed ranks (W) 4 Number of pairs 11 Median of differences Median -0.0003106 How effective was the pairing? rs (Spearman) 0.8727 P value (one tailed) 0.0005 P value summary *** Was the pairing significantly effective? Yes ___________________________________ Test results for RL Model vs Model 1 Column H RL Model vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.4648 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 42 , -24 Sum of signed ranks (W) 18 Number of pairs 11 Median of differences Median 0.001637 How effective was the pairing? rs (Spearman) 0.7727 P value (one tailed) 0.0037 P value summary ** Was the pairing significantly effective? Yes ___________________________________ Test results for RL Model vs Model 4 Column H RL Model vs. vs. Column D Model 4 (¦Á1 = 0, ¦Á2 = 0) Wilcoxon matched-pairs signed rank test P value 0.0537 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 11 , -55 Sum of signed ranks (W) -44 Number of pairs 11 Median of differences Median -0.005498 How effective was the pairing? rs (Spearman) 0.9273 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes _______________________________________________________________________________________________________________________________________________________________________ Cross-validated model likelihood during switching period (each data is the median value of corresponding likelihood distribution, each row contains data from one animal) (For two mice, we cannot get good fit under model 7, thus their data is empty) Model 1 (full model) Model 2 (¦Á1 = 0) Model 3 (¦Á2 = 0) Model 4 (¦Á1 = 0, ¦Á2 = 0) Model 5 (¦Â = 0) Model 6 (¦Ã1 = 1) Model 7 (¦Ã2 = 0) RL Model 0.661467254542798 0.666767648378375 0.667105208666278 0.663174482940712 0.614474543860248 0.551715640137223 0.664243508333661 0.6859906966535 0.690525579238118 0.683936052428125 0.690691265336681 0.643627996379173 0.56409517986147 0.682508965085826 0.686728270858911 0.655127179606084 0.661322291056507 0.656470711030463 0.660907511978776 0.597597725897003 0.554579624894455 0.64895131824921 0.661051053715667 0.678355973574554 0.675148136649037 0.674521722135066 0.674630498375896 0.565206077226369 0.586233787793979 0.637141269846546 0.662621021336722 0.624338962732577 0.622987408846936 0.62236504117652 0.62652180662462 0.558589350890113 0.564872763598481 0.616047494106399 0.568301459725568 0.558916796946658 0.566434448258263 0.563479040830824 0.435271662976622 0.554254516360639 0.564493472591877 0.569875789017332 0.679158933729056 0.678648962629209 0.684343533550351 0.680587387766408 0.625441844612695 0.567818642121218 0.658699875022933 0.67605214264005 0.671174579219691 0.671442670811448 0.66635718651212 0.667783802368335 0.567890744504116 0.570095942786948 0.656442512081763 0.668021691087648 0.69926644699338 0.697262439286244 0.697080528972708 0.698088978108643 0.651322932791917 0.586871196515677 0.674367868797473 0.688948963091246 0.67812211965762 0.675920349500463 0.678208902759159 0.677532956911346 0.59815795851504 0.569154146818498 0.665109078247896 0.669934156295709 0.689095022635222 0.680663821244454 0.685038026672171 0.682447383895853 0.607499249076349 0.575653914209572 0.671740713439787 0.675980531256536 ___________________________________ Test results for Model 2 vs Model 1 Column B Model 2 (¦Á1 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.5195 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 25 , -41 Sum of signed ranks (W) -16 Number of pairs 11 Median of differences Median -0.001352 How effective was the pairing? rs (Spearman) 0.9818 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 3 vs Model 1 Column C Model 3 (¦Á2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.4648 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 24 , -42 Sum of signed ranks (W) -18 Number of pairs 11 Median of differences Median -0.001974 How effective was the pairing? rs (Spearman) 0.9727 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 4 vs Model 1 Column D Model 4 (¦Á1 = 0, ¦Á2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.8311 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 30 , -36 Sum of signed ranks (W) -6 Number of pairs 11 Median of differences Median -0.0005892 How effective was the pairing? rs (Spearman) 0.9818 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 5 vs Model 1 Column E Model 5 (¦Â = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0010 Exact or approximate P value? Exact P value summary *** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 0 , -66 Sum of signed ranks (W) -66 Number of pairs 11 Median of differences Median -0.06575 How effective was the pairing? rs (Spearman) 0.7818 P value (one tailed) 0.0032 P value summary ** Was the pairing significantly effective? Yes ___________________________________ Test results for Model 6 vs Model 1 Column F Model 6 (¦Ã1 = 1) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0010 Exact or approximate P value? Exact P value summary *** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 0 , -66 Sum of signed ranks (W) -66 Number of pairs 11 Median of differences Median -0.109 How effective was the pairing? rs (Spearman) 0.6909 P value (one tailed) 0.0113 P value summary * Was the pairing significantly effective? Yes ___________________________________ Test results for Model 7 vs Model 1 Column G Model 7 (¦Ã2 = 0) vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0039 Exact or approximate P value? Exact P value summary ** Significantly different (P < 0.05)? Yes One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 0 , -45 Sum of signed ranks (W) -45 Number of pairs 9 Median of differences Median -0.01473 How effective was the pairing? rs (Spearman) 0.8167 P value (one tailed) 0.0054 P value summary ** Was the pairing significantly effective? Yes ___________________________________ Test results for RL Model vs Model 1 Column H RL Model vs. vs. Column A Model 1 (full model) Wilcoxon matched-pairs signed rank test P value 0.0674 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 12 , -54 Sum of signed ranks (W) -42 Number of pairs 11 Median of differences Median -0.003153 How effective was the pairing? rs (Spearman) 0.9182 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes ___________________________________ Test results for RL Model vs Model 4 Column H RL Model vs. vs. Column D Model 4 (¦Á1 = 0, ¦Á2 = 0) Wilcoxon matched-pairs signed rank test P value 0.0674 Exact or approximate P value? Exact P value summary ns Significantly different (P < 0.05)? No One- or two-tailed P value? Two-tailed Sum of positive, negative ranks 12 , -54 Sum of signed ranks (W) -42 Number of pairs 11 Median of differences Median -0.004535 How effective was the pairing? rs (Spearman) 0.9636 P value (one tailed) <0.0001 P value summary **** Was the pairing significantly effective? Yes _______________________________________________________________________________________________________________________________________________________________________ Model 1 parameters during stable period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Á1 ¦Á2 ¦Â ¦Ã1 ¦Ã2 -0.323297348695445 0.650513039158036 0.318032066453331 4.47433816107523 1.18556603654215 0.139663965763802 1.31877073416829 0.26814218401837 5.63245307966715 0.731913566823535 -0.373857175831545 0.372189036337975 0.138531308249218 4.21851821153347 0.819046201425176 -0.210957561507224 0.690576351530722 0.184498862466163 5.45325075660222 0.917082569863756 -0.175763411869627 0.621844447479845 0.196105194567479 3.59395527662495 0.70421701364819 -0.0455306516494723 0.628048260209133 0.195312549688176 2.62685151803084 0.541432076055062 -0.0626921087874136 0.138813235812624 0.189365284303302 4.87477029668532 0.914569185146946 -0.219764138541675 0.926920417338282 0.282043193777983 5.10122966380818 1.16307989995154 -0.0940885297714374 0.599574611008335 0.049476660025793 5.29200817836405 0.351524607335736 -0.325909024147561 1.48376690809343 0.316685150586241 4.74425741552646 1.20211442771937 -0.382846183401845 0.443900389580205 0.191996891129622 5.37741834132009 1.02106646278701 __________ Statistics ¦Á1 ¦Á2 ¦Â ¦Ã1 ¦Ã2 Number of values 11 11 11 11 11 Minimum -0.3828 0.1388 0.04948 2.627 0.3515 25% Percentile -0.3259 0.4439 0.1845 4.219 0.7042 Median -0.211 0.628 0.1953 4.875 0.9146 75% Percentile -0.06269 0.9269 0.282 5.377 1.163 Maximum 0.1397 1.484 0.318 5.632 1.202 Mean -0.1886 0.7159 0.2118 4.672 0.8683 Std. Deviation 0.1624 0.3947 0.08017 0.9075 0.2736 Std. Error of Mean 0.04896 0.119 0.02417 0.2736 0.0825 Lower 95% CI of mean -0.2977 0.4507 0.158 4.062 0.6845 Upper 95% CI of mean -0.07955 0.9811 0.2657 5.281 1.052 Sum -2.075 7.875 2.33 51.39 9.552 Wilcoxon Signed Rank Test Theoretical median 0 0 0 0 0 Actual median -0.211 0.628 0.1953 4.875 0.9146 Discrepancy -0.211 0.628 0.1953 4.875 0.9146 Sum of signed ranks (W) -58 66 66 66 66 Sum of positive ranks 4 66 66 66 66 Sum of negative ranks -62 0 0 0 0 P value (two tailed) 0.0068 0.0010 0.0010 0.0010 0.0010 Exact or estimate? Exact Exact Exact Exact Exact Significant (alpha=0.05)? Yes Yes Yes Yes Yes _______________________________________________________________________________________________________________________________________________________________________ Model 4 parameters during stable period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Â ¦Ã1 ¦Ã2 0.368759565450361 4.43416205251345 1.22840745440463 0.157173686046252 5.31645187266423 0.635135939574201 0.225387372481812 4.23497224348028 0.883295616459273 0.198432135117019 5.41844847702009 0.903495501776791 0.165048449327923 3.60404393974031 0.592755129560538 0.123976093390952 2.57604743195539 0.439939693979846 0.199541807981581 4.87154683823752 0.930418650609056 0.298413035443758 4.94930613841618 1.18163463446809 0.0517421447068144 5.16723073881067 0.37130390921292 0.322450581606887 4.53101770491995 1.14543621901415 0.311075248365605 5.41642500389203 1.20753107439981 __________ Statistics ¦Â ¦Ã1 ¦Ã2 Number of values 11 11 11 Minimum 0.05174 2.576 0.3713 25% Percentile 0.1572 4.235 0.5928 Median 0.1995 4.872 0.9035 75% Percentile 0.3111 5.316 1.182 Maximum 0.3688 5.418 1.228 Mean 0.2202 4.593 0.8654 Std. Deviation 0.09617 0.873 0.314 Std. Error of Mean 0.029 0.2632 0.09466 Lower 95% CI of mean 0.1556 4.006 0.6545 Upper 95% CI of mean 0.2848 5.179 1.076 Sum 2.422 50.52 9.519 Wilcoxon Signed Rank Test Theoretical median 0 0 0 Actual median 0.1995 4.872 0.9035 Discrepancy 0.1995 4.872 0.9035 Sum of signed ranks (W) 66 66 66 Sum of positive ranks 66 66 66 Sum of negative ranks 0 0 0 P value (two tailed) 0.0010 0.0010 0.0010 Exact or estimate? Exact Exact Exact Significant (alpha=0.05)? Yes Yes Yes _______________________________________________________________________________________________________________________________________________________________________ RL Model parameters during stable period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Ã ¦Á 2.92426911739763 0.0273824652102646 2.99013351534421 0.0287617378983723 3.40924104893005 0.0258105243945861 3.78086971138408 0.017555883182599 3.34583700732368 0.016753507650732 3.11305274029688 0.00304181703304551 4.04777099696206 0.0207022626151462 3.19964897157014 0.0284828639791884 3.50454520385347 0.020911181775842 3.22730808700351 0.0339617425373909 3.57323999099512 0.0215571324499448 __________ Statistics ¦Ã ¦Á Number of values 11 11 Minimum 2.924 0.003042 25% Percentile 3.113 0.01756 Median 3.346 0.02156 75% Percentile 3.573 0.02848 Maximum 4.048 0.03396 Mean 3.374 0.02227 Std. Deviation 0.3388 0.008266 Std. Error of Mean 0.1022 0.002492 Lower 95% CI of mean 3.147 0.01671 Upper 95% CI of mean 3.602 0.02782 Sum 37.12 0.2449 One sample t test Theoretical mean 0 0 Actual mean 3.374 0.02227 Discrepancy 3.374 0.02227 95% CI of discrepancy 3.147 to 3.602 0.01671 to 0.02782 t, df t=33.03 df=10 t=8.934 df=10 P value (two tailed) <0.0001 <0.0001 Significant (alpha=0.05)? Yes Yes Wilcoxon Signed Rank Test Theoretical median 0 0 Actual median 3.346 0.02156 Discrepancy 3.346 0.02156 Sum of signed ranks (W) 66 66 Sum of positive ranks 66 66 Sum of negative ranks 0 0 P value (two tailed) 0.0010 0.0010 Exact or estimate? Exact Exact Significant (alpha=0.05)? Yes Yes ________________________________________________________________________________________________________________________________________________________ Model 1 parameters during switching period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Á1 ¦Á2 ¦Â ¦Ã1 ¦Ã2 -0.635754520506568 -0.0175876629528893 0.745622158364345 4.02974214632767 0.836207777253803 -0.666259053886691 0.0329532880983406 0.521027610626776 5.32525390879474 0.585893170440441 -0.811213271637351 0.0904925125718944 0.642095110384233 3.84271378848833 0.486250226364041 -0.164237125070149 -0.133051529004026 0.525960056626085 4.25320370114617 0.449318744992221 -0.548859674186028 -0.238443821241993 0.861729060881668 2.75608700949499 0.477282051631373 -0.351766366525416 0.0279020971331059 0.758746026341416 1.86794475142836 0.335715831561127 -0.127500383911865 -0.14993060946767 0.30945282407571 4.31652220218125 0.400058513243611 -0.472283069670777 0.354601985459948 0.589838392306324 4.47256436239231 0.569565259059334 -0.0411464887181105 -0.131522010007461 0.214169417557282 4.7877322654674 0.312446549186879 -0.826114520946013 0.0855822070038221 0.669760523604782 4.25080568875609 0.788360748653206 -0.715771006872667 0.200599938644168 0.469515463895454 4.43408456592814 0.523707307700849 __________ Statistics ¦Á1 ¦Á2 ¦Â ¦Ã1 ¦Ã2 Number of values 11 11 11 11 11 Minimum -0.8261 -0.2384 0.2142 1.868 0.3124 25% Percentile -0.7158 -0.1331 0.4695 3.843 0.4001 Median -0.5489 0.0279 0.5898 4.253 0.4863 75% Percentile -0.1642 0.09049 0.7456 4.473 0.5859 Maximum -0.04115 0.3546 0.8617 5.325 0.8362 Mean -0.4874 0.01105 0.5734 4.031 0.5241 Std. Deviation 0.2795 0.1722 0.1939 0.9552 0.1667 Std. Error of Mean 0.08427 0.05193 0.05846 0.288 0.05027 Lower 95% CI of mean -0.6751 -0.1047 0.4432 3.389 0.4121 Upper 95% CI of mean -0.2996 0.1268 0.7037 4.672 0.6361 Sum -5.361 0.1216 6.308 44.34 5.765 Wilcoxon Signed Rank Test Theoretical median 0 0 0 0 0 Actual median -0.5489 0.0279 0.5898 4.253 0.4863 Discrepancy -0.5489 0.0279 0.5898 4.253 0.4863 Sum of signed ranks (W) -66 2 66 66 66 Sum of positive ranks 0 34 66 66 66 Sum of negative ranks -66 -32 0 0 0 P value (two tailed) 0.0010 0.9658 0.0010 0.0010 0.0010 Exact or estimate? Exact Exact Exact Exact Exact Significant (alpha=0.05)? Yes No Yes Yes Yes _______________________________________________________________________________________________________________________________________________________________________ Model 4 parameters during switching period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Â ¦Ã1 ¦Ã2 0.563269900142339 4.10659718983684 0.653939374463692 0.47684536020931 5.33972782539224 0.412701093853786 0.364446565441629 3.87386386029241 0.283913003393786 0.412958653103308 4.31777051263899 0.346186024091691 0.44802381311526 2.82221875636666 0.285617138806664 0.652782707949103 1.91650036341232 0.289074521791127 0.232626038944611 4.38601651166887 0.294965293348345 0.623509979188743 4.42307982512228 0.534800884154146 0.168906606382166 4.85276888621308 0.246864782217582 0.519367260275325 4.2648993490903 0.560789588297274 0.398941770553542 4.46164902530025 0.36893145201328 __________ Statistics Number of values 11 11 11 Minimum 0.1689 1.917 0.2469 25% Percentile 0.3644 3.874 0.2856 Median 0.448 4.318 0.3462 75% Percentile 0.5633 4.462 0.5348 Maximum 0.6528 5.34 0.6539 Mean 0.442 4.07 0.3889 Std. Deviation 0.1505 0.9453 0.1358 Std. Error of Mean 0.04537 0.285 0.04096 Lower 95% CI of mean 0.3409 3.434 0.2976 Upper 95% CI of mean 0.5431 4.705 0.4801 Sum 4.862 44.77 4.278 Wilcoxon Signed Rank Test Theoretical median 0 0 0 Actual median 0.448 4.318 0.3462 Discrepancy 0.448 4.318 0.3462 Sum of signed ranks (W) 66 66 66 Sum of positive ranks 66 66 66 Sum of negative ranks 0 0 0 P value (two tailed) 0.0010 0.0010 0.0010 Exact or estimate? Exact Exact Exact Significant (alpha=0.05)? Yes Yes Yes _______________________________________________________________________________________________________________________________________________________________________ RL Model parameters during switching period (each data is the median value of corresponding parameter distribution, each row contains data from one animal) ¦Ã ¦Á 0.759353329515081 0.160480483156628 1.09339904563043 0.0814463499037843 0.774399408144855 0.11243502094431 0.828070087379419 0.10024272701387 0.766372680748387 0.146926780724596 0.114909370783732 0.216677769131792 1.16612494432507 0.0848914951253133 0.428447986725565 0.198807268183802 1.4019670380282 0.0622595844955445 0.927231277223374 0.120092661076847 1.04929828652389 0.0963674565416321 __________ Statistics ¦Ã ¦Á Number of values 11 11 Minimum 0.1149 0.06226 25% Percentile 0.7594 0.08489 Median 0.8281 0.1124 75% Percentile 1.093 0.1605 Maximum 1.402 0.2167 Mean 0.8463 0.1255 Std. Deviation 0.3534 0.04964 Std. Error of Mean 0.1066 0.01497 Lower 95% CI of mean 0.6089 0.09216 Upper 95% CI of mean 1.084 0.1589 Sum 9.31 1.381 Wilcoxon Signed Rank Test Theoretical median 0 0 Actual median 0.8281 0.1124 Discrepancy 0.8281 0.1124 Sum of signed ranks (W) 66 66 Sum of positive ranks 66 66 Sum of negative ranks 0 0 P value (two tailed) 0.0010 0.0010 Exact or estimate? Exact Exact Significant (alpha=0.05)? Yes Yes