<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.2 20190208//EN"  "JATS-archivearticle1.dtd"><?covid-19-tdm ?><article article-type="research-article" dtd-version="1.2" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="nlm-ta">elife</journal-id><journal-id journal-id-type="publisher-id">eLife</journal-id><journal-title-group><journal-title>eLife</journal-title></journal-title-group><issn pub-type="epub" publication-format="electronic">2050-084X</issn><publisher><publisher-name>eLife Sciences Publications, Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">69336</article-id><article-id pub-id-type="doi">10.7554/eLife.69336</article-id><article-categories><subj-group subj-group-type="display-channel"><subject>Tools and Resources</subject></subj-group><subj-group subj-group-type="heading"><subject>Epidemiology and Global Health</subject></subj-group></article-categories><title-group><article-title>Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="author-234189"><name><surname>Karlinsky</surname><given-names>Ariel</given-names></name><contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0003-0966-5837</contrib-id><email>ariel.karlinsky@mail.huji.ac.il</email><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="con1"/><xref ref-type="fn" rid="conf1"/></contrib><contrib contrib-type="author" corresp="yes" id="author-166224"><name><surname>Kobak</surname><given-names>Dmitry</given-names></name><contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0002-5639-7209</contrib-id><email>dmitry.kobak@uni-tuebingen.de</email><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="other" rid="fund1"/><xref ref-type="other" rid="fund3"/><xref ref-type="other" rid="fund4"/><xref ref-type="fn" rid="con2"/><xref ref-type="fn" rid="conf1"/></contrib><aff id="aff1"><label>1</label><institution>Hebrew University</institution><addr-line><named-content content-type="city">Jerusalem</named-content></addr-line><country>Israel</country></aff><aff id="aff2"><label>2</label><institution>Institute for Ophthalmic Research, University of Tübingen</institution><addr-line><named-content content-type="city">Tübingen</named-content></addr-line><country>Germany</country></aff></contrib-group><contrib-group content-type="section"><contrib contrib-type="senior_editor"><name><surname>Davenport</surname><given-names>Miles P</given-names></name><role>Senior Editor</role><aff><institution>University of New South Wales</institution><country>Australia</country></aff></contrib><contrib contrib-type="editor"><name><surname>Lipsitch</surname><given-names>Marc</given-names></name><role>Reviewing Editor</role><aff><institution>Harvard TH Chan School of Public Health</institution><country>United States</country></aff></contrib></contrib-group><pub-date date-type="publication" publication-format="electronic"><day>30</day><month>06</month><year>2021</year></pub-date><pub-date pub-type="collection"><year>2021</year></pub-date><volume>10</volume><elocation-id>e69336</elocation-id><history><date date-type="received" iso-8601-date="2021-04-13"><day>13</day><month>04</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-06-29"><day>29</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement>© 2021, Karlinsky and Kobak</copyright-statement><copyright-year>2021</copyright-year><copyright-holder>Karlinsky and Kobak</copyright-holder><ali:free_to_read/><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><ali:license_ref>http://creativecommons.org/licenses/by/4.0/</ali:license_ref><license-p>This article is distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use and redistribution provided that the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="elife-69336-v3.pdf"/><related-article ext-link-type="doi" id="ra1" related-article-type="commentary" xlink:href="10.7554/eLife.71974"/><abstract><p>Comparing the impact of the COVID-19 pandemic between countries or across time is difficult because the reported numbers of cases and deaths can be strongly affected by testing capacity and reporting policy. Excess mortality, defined as the increase in all-cause mortality relative to the expected mortality, is widely considered as a more objective indicator of the COVID-19 death toll. However, there has been no global, frequently updated repository of the all-cause mortality data across countries. To fill this gap, we have collected weekly, monthly, or quarterly all-cause mortality data from 103 countries and territories, openly available as the regularly updated World Mortality Dataset. We used this dataset to compute the excess mortality in each country during the COVID-19 pandemic. We found that in several worst-affected countries (Peru, Ecuador, Bolivia, Mexico) the excess mortality was above 50% of the expected annual mortality (Peru, Ecuador, Bolivia, Mexico) or above 400 excess deaths per 100,000 population (Peru, Bulgaria, North Macedonia, Serbia). At the same time, in several other countries (e.g. Australia and New Zealand) mortality during the pandemic was below the usual level, presumably due to social distancing measures decreasing the non-COVID infectious mortality. Furthermore, we found that while many countries have been reporting the COVID-19 deaths very accurately, some countries have been substantially underreporting their COVID-19 deaths (e.g. Nicaragua, Russia, Uzbekistan), by up to two orders of magnitude (Tajikistan). Our results highlight the importance of open and rapid all-cause mortality reporting for pandemic monitoring.</p></abstract><abstract abstract-type="executive-summary"><title>eLife digest</title><p>Countries around the world reported 4.2 million deaths from SARS-CoV-2 (the virus that causes COVID-19) from the beginning of pandemic until the end of July 2021, but the actual number of deaths is likely higher. While some countries may have imperfect systems for counting deaths, others may have intentionally underreported them. To get a better estimate of deaths from an event such as a pandemic, scientists often compare the total number of deaths in a country during the event to the expected number of deaths based on data from previous years. This tells them how many excess deaths occurred during the event.</p><p>To provide a more accurate count of deaths caused by COVID-19, Karlinsky and Kobak built a database called the World Mortality Dataset. It includes information on deaths from all causes from 103 countries. Karlinsky and Kobak used the database to compare the number of reported COVID-19 deaths reported to the excess deaths from all causes during the pandemic.</p><p>Some of the hardest hit countries, including Peru, Ecuador, Bolivia, and Mexico, experienced over 50% more deaths than expected during the pandemic. Meanwhile, other countries like Australia and New Zealand, reported fewer deaths than normal. This is likely because social distancing measures reduced deaths from infections like influenza. Many countries reported their COVID-19 deaths accurately, but Karlinsky and Kobak argue that other countries, including Nicaragua, Russia, and Uzbekistan, underreported COVID-19 deaths.</p><p>Using their database, Karlinsky and Kobak estimate that, in those countries, there have been at least 1.4 times more deaths due to COVID-19 than reported – adding over 1 million extra deaths in total. But they note that the actual number is likely much higher because data from more than 100 countries were not available to include in the database. The World Mortality Dataset provides a more accurate picture of the number of people who died because of the COVID-19 pandemic, and it is available online and updated daily. The database may help scientists develop better mitigation strategies for this pandemic or future ones.</p></abstract><kwd-group kwd-group-type="author-keywords"><kwd>COVID</kwd><kwd>mortality</kwd><kwd>data</kwd><kwd>international</kwd></kwd-group><kwd-group kwd-group-type="research-organism"><title>Research organism</title><kwd>Human</kwd></kwd-group><funding-group><award-group id="fund1"><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100001659</institution-id><institution>Deutsche Forschungsgemeinschaft</institution></institution-wrap></funding-source><award-id>390727645 and BE5601/4-1</award-id><principal-award-recipient><name><surname>Kobak</surname><given-names>Dmitry</given-names></name></principal-award-recipient></award-group><award-group id="fund3"><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100002347</institution-id><institution>Federal Ministry of Education and Research</institution></institution-wrap></funding-source><award-id>FKZ 01GQ1601 and 01IS18039A</award-id><principal-award-recipient><name><surname>Kobak</surname><given-names>Dmitry</given-names></name></principal-award-recipient></award-group><award-group id="fund4"><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/100000002</institution-id><institution>National Institutes of Health</institution></institution-wrap></funding-source><award-id>U19MH114830</award-id><principal-award-recipient><name><surname>Kobak</surname><given-names>Dmitry</given-names></name></principal-award-recipient></award-group><funding-statement>The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.</funding-statement></funding-group><custom-meta-group><custom-meta specific-use="meta-only"><meta-name>Author impact statement</meta-name><meta-value>The World Mortality Dataset and paper is the largest dataset of all-cause mortality currently in existence for tracking mortality and excess mortality during the COVID-19 pandemic.</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>The impact of COVID-19 on a given country is usually assessed via the number of cases and the number of deaths, two statistics that have been reported daily by each country and put together into international dashboards such as the ones maintained by the World Health Organization (<ext-link ext-link-type="uri" xlink:href="https://covid19.who.int">https://covid19.who.int</ext-link>) or by the Johns Hopkins University (<ext-link ext-link-type="uri" xlink:href="https://coronavirus.jhu.edu">https://coronavirus.jhu.edu</ext-link>) (<xref ref-type="bibr" rid="bib17">Dong et al., 2020</xref>). However, both metrics can be heavily affected by limited testing availability and by different definitions of ‘COVID-19 death’ used by different countries (<xref ref-type="bibr" rid="bib57">Riffe et al., 2021</xref>): for example, some countries count only PCR-confirmed COVID-19 deaths, while others include suspected COVID-19 deaths as well.</p><p>Excess mortality, defined as the increase of the all-cause mortality over the mortality expected based on historic trends, has long been used to estimate the death toll of pandemics and other extreme events—from the Great Plague of London in 1665 (as described in <xref ref-type="bibr" rid="bib12">Boka and Wainer, 2020</xref>), to the influenza epidemic in London in 1875 (<xref ref-type="bibr" rid="bib19">Farr, 1885</xref>; <xref ref-type="bibr" rid="bib39">Langmuir, 1976</xref>), the XX–XXI century influenza pandemics of 1918, 1957, 1968, 2009 (<xref ref-type="bibr" rid="bib48">Murray et al., 2006</xref>; <xref ref-type="bibr" rid="bib67">Viboud et al., 2005</xref>; <xref ref-type="bibr" rid="bib68">Viboud et al., 2016</xref>; <xref ref-type="bibr" rid="bib59">Simonsen et al., 2013</xref>) as well as seasonal influenza epidemics (<xref ref-type="bibr" rid="bib30">Housworth and Langmuir, 1974</xref>), and more recently for example Hurricane Maria in Puerto-Rico in 2016 (<xref ref-type="bibr" rid="bib44">Milken Institute, 2018</xref>). Even though the excess mortality does not exactly equal the mortality from COVID-19 infections, the consensus is that for many countries it is the most objective possible indicator of the COVID-19 death toll (<xref ref-type="bibr" rid="bib9">Beaney et al., 2020</xref>; <xref ref-type="bibr" rid="bib41">Leon et al., 2020</xref>). Excess mortality has already been used to estimate the COVID-19 impact in different countries, both in academic literature (e.g. <xref ref-type="bibr" rid="bib35">Kontis et al., 2020</xref>; <xref ref-type="bibr" rid="bib4">Alicandro et al., 2020</xref>; <xref ref-type="bibr" rid="bib27">Ghafari et al., 2021</xref>; <xref ref-type="bibr" rid="bib73">Woolf et al., 2020a</xref>; <xref ref-type="bibr" rid="bib74">Woolf et al., 2020b</xref>; <xref ref-type="bibr" rid="bib71">Weinberger et al., 2020</xref>; <xref ref-type="bibr" rid="bib11">Blangiardo et al., 2020</xref>; <xref ref-type="bibr" rid="bib33">Kobak, 2021a</xref>; <xref ref-type="bibr" rid="bib47">Modi et al., 2021</xref>; <xref ref-type="bibr" rid="bib13">Bradshaw et al., 2021</xref>; <xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>, among many others) and by major media outlets. It has also been used to compare COVID-19 impact to the impact of major influenza pandemics (<xref ref-type="bibr" rid="bib21">Faust et al., 2020</xref>; <xref ref-type="bibr" rid="bib54">Petersen et al., 2020</xref>).</p><p>Measuring and monitoring excess mortality across different countries requires, first and foremost, a comprehensive and regularly-updated dataset on all-cause mortality. However, there has been no single resource where such data would be collected from all over the world. The <italic>World Mortality Dataset</italic> presented here aims to fill this gap by combining publicly available information on country-level mortality, culled and harmonized from various sources.</p><p>Several teams have already started to collect such data. In April 2020, EuroStat (<ext-link ext-link-type="uri" xlink:href="http://ec.europa.eu/eurostat">http://ec.europa.eu/eurostat</ext-link>) began collecting total weekly deaths across European countries, ‘in order to support the policy and research efforts related to COVID-19’. At the time of writing, this dataset covers 36 European countries and also contains sub-national (NUTS1–3 regions) data as well as data disaggregated by age groups and by sex for some countries. In May 2020, the Human Mortality Database (<ext-link ext-link-type="uri" xlink:href="http://mortality.org">http://mortality.org</ext-link>), a joint effort by the University of California, Berkeley, and Max Planck Institute for Demographic Research (<xref ref-type="bibr" rid="bib8">Barbieri et al., 2015</xref>), started compiling the <italic>Short Term Mortality Fluctuations</italic> (STMF) dataset (<xref ref-type="bibr" rid="bib61">STMF, 2021</xref>; <xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>; <xref ref-type="bibr" rid="bib51">Németh et al., 2021</xref>). This dataset consists of weekly data, disaggregated by five age groups and by sex, and currently contains 35 countries with 2020 data. STMF only includes countries with complete high-quality vital registration data in all age groups. Both datasets are regularly updated and have considerable overlap, covering together 44 countries.</p><p>In parallel, the EuroMOMO project (<ext-link ext-link-type="uri" xlink:href="https://www.euromomo.eu">https://www.euromomo.eu</ext-link>), existing since 2008, has been displaying weekly excess mortality in 23 European countries, but without giving access to the underlying data. Another source of data is the UNDATA initiative (<ext-link ext-link-type="uri" xlink:href="http://data.un.org">http://data.un.org</ext-link>; search for ‘Deaths by month of death’) by the United Nations, collecting monthly mortality data across a large number of countries. However, information there is updated very slowly, with January–June 2020 data currently available for only four countries.</p><p>Media outlets such as the <italic>Financial Times</italic>, <italic>The Economist</italic>, the <italic>New York Times</italic>, and the <italic>Wall Street Journal</italic> have been compiling and openly sharing their own datasets in order to report on the all-cause mortality in 2020. However, these datasets are infrequently updated and their future is unclear. For example, the <italic>New York Times</italic> announced in early 2021 that they would stop tracking excess deaths due to staffing changes.</p><p>Here, we present the <italic>World Mortality Dataset</italic> that aims to provide regularly-updated all-cause mortality numbers from all over the world. The dataset is openly available at <ext-link ext-link-type="uri" xlink:href="https://github.com/akarlinsky/world_mortality">https://github.com/akarlinsky/world_mortality</ext-link> and is updated almost daily. Our dataset builds upon the EuroStat and the STMF datasets, adding 59 additional countries — many more than any previous media or academic effort. At the time of writing, our dataset comprises 103 countries and territories. After the initial release of our manuscript, the dataset has been incorporated into the excess mortality trackers by <italic>Our World in Data</italic> (<xref ref-type="bibr" rid="bib28">Giattino et al., 2020</xref>), <italic>The Economist</italic>, and the <italic>Financial Times</italic>. While not all countries provide equally detailed and reliable data, we believe that information from all 103 countries is reliable enough to allow computation of excess mortality (see Discussion).</p><p>Our analysis (updated almost daily at <ext-link ext-link-type="uri" xlink:href="https://github.com/dkobak/excess-mortality">https://github.com/dkobak/excess-mortality</ext-link>) showed statistically significant positive excess mortality in 69 out of 103 countries. Moreover, it suggests that the true COVID-19 death toll in several countries is over an order of magnitude larger than the official COVID-19 death count.</p></sec><sec id="s2" sec-type="results"><title>Results</title><sec id="s2-1"><title>Excess mortality</title><p>We collected the all-cause mortality data from 103 countries and territories from 2015 onward into the openly available <italic>World Mortality Dataset</italic>. This includes 50 countries with weekly data, 51 countries with monthly data, and two countries with quarterly data (<xref ref-type="fig" rid="fig1">Figure 1</xref>). See Materials and methods for our data collection strategy. Briefly, we obtained the data from the websites of National Statistics Offices (NSOs). If we were unable to locate the data ourselves, we contacted the NSO for guidance. The data from EuroStat and STMF were included as is, with few exceptions (see Materials and methods). An important caveat is that recent (2020 and 2021) data are often preliminary and subject to backwards revisions, which we incorporate into our dataset. Other caveats and limitations are listed in the Materials and methods section.</p><fig id="fig1" position="float"><label>Figure 1.</label><caption><title>Countries in the World Mortality Dataset are shown in blue.</title><p>Small countries and territories are shown with circles.</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig1-v3.tif"/></fig><p>For each country, we predicted the ‘baseline’ mortality in 2020 based on the 2015–2019 data (accounting for linear trend and seasonal variation; see Materials and methods). We then obtained excess mortality as the difference between the actual 2020–2021 all-cause mortality and our baseline (<xref ref-type="fig" rid="fig2">Figure 2</xref>, <xref ref-type="fig" rid="fig2s1">Figure 2—figure supplement 1</xref>). For each country, we computed the total excess mortality from the beginning of the COVID-19 pandemic (from March 2020) (<xref ref-type="table" rid="table1">Table 1</xref>). The total excess mortality was positive and significantly different from zero in 69 countries; negative and significantly different from zero in seven countries; not significantly different from zero (<inline-formula><mml:math id="inf1"><mml:mrow><mml:mi>z</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>2</mml:mn></mml:mrow></mml:math></inline-formula>) in 25 countries. For South Africa and Argentina, there was no historic data available in order to assess the significance, but the increase in mortality was very large and clearly associated with COVID-19 (<xref ref-type="bibr" rid="bib13">Bradshaw et al., 2021</xref>; <xref ref-type="bibr" rid="bib56">Rearte et al., 2021</xref>).</p><fig-group><fig id="fig2" position="float"><label>Figure 2.</label><caption><title>Excess mortality time series.</title><p>Each subplot shows baseline mortality (black), mortality in 2015–2019 (gray), in 2020 (red) and in 2021 (blue). Excess mortality is shown in red/blue shading. The numbers in each subplot are: total excess mortality (red), excess mortality per 100,000 population (black), excess mortality as a percentage of annual baseline mortality (gray), and undercount ratio of COVID-19 deaths (blue). See text for the exact definitions. All numbers were rounded to two significant digits; numbers below 100 to one significant digit. The <inline-formula><mml:math id="inf2"><mml:mi>y</mml:mi></mml:math></inline-formula>-axis in each subplot starts at 0 and goes until 200% where 100% corresponds to the average baseline mortality. The <inline-formula><mml:math id="inf3"><mml:mi>x</mml:mi></mml:math></inline-formula>-axis covers the entire year. Asterisks mark excess mortality estimates that were downwards corrected (see Materials and methods). Countries are sorted by the excess mortality as a percentage of annual baseline mortality (gray number). Undercount estimates are not shown for countries with negative total excess deaths and for selected countries where excess deaths were likely not related to the COVID-19 pandemic (Hong Kong, Thailand, Cuba); see Materials and methods.</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig2-v3.tif"/></fig><fig id="fig2s1" position="float" specific-use="child-fig"><label>Figure 2—figure supplement 1.</label><caption><title>Excess mortality time series, normalized per population size.</title><p>The figure is fully analogous to <xref ref-type="fig" rid="fig2">Figure 2</xref>, but countries are sorted by the excess mortality per 100,000 population, and all shown curves are normalized to yield mortality per 1000 people per year (each data point shows what mortality per 1000 people per year would be if the death rate stayed at the same level throughout the year).</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig2-figsupp1-v3.tif"/></fig></fig-group><table-wrap id="table1" position="float"><label>Table 1.</label><caption><title>Excess mortality metrics for all countries in the dataset.</title><p>Abbreviations: ‘w’ – weekly data, ‘m’ – monthly data, ‘q’ – quarterly data. All numbers were rounded to two significant digits; numbers below 100 — to one significant digit. See text for the exact definitions of all reported metrics. ‘Official’ means the official daily reported number of COVID-19 deaths. Undercount estimates are not shown for countries with negative total excess deaths and for selected countries where excess deaths were likely not related to the COVID-19 pandemic (Hong Kong, Thailand, Cuba); see Materials and methods.</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Country</th><th>Data until</th><th>Type</th><th>Official</th><th>Excess</th><th>std</th><th>z</th><th>Undercount</th><th>Per 100k</th><th>Increase</th></tr></thead><tbody><tr><td>Albania</td><td>Mar 31, 2021</td><td>m</td><td>2,200</td><td>9,300</td><td>±810</td><td>11.4</td><td>4.2</td><td>320</td><td>43</td></tr><tr><td>Andorra</td><td>Dec 31, 2020</td><td>m</td><td>80</td><td>80</td><td>±30</td><td>3.1</td><td>1.0</td><td>110</td><td>25</td></tr><tr><td>Argentina</td><td>Dec 31, 2020</td><td>m</td><td>43,000</td><td>41,000</td><td>±nan</td><td>nan</td><td>1.0</td><td>90</td><td>12</td></tr><tr><td>Armenia</td><td>Apr 30, 2021</td><td>m</td><td>4,100</td><td>8,300</td><td>±840</td><td>10.0</td><td>2.0</td><td>280</td><td>33</td></tr><tr><td>Aruba</td><td>Dec 31, 2020</td><td>m</td><td>50</td><td>50</td><td>±30</td><td>1.5</td><td>1.0</td><td>50</td><td>7</td></tr><tr><td>Australia</td><td>Mar 28, 2021</td><td>w</td><td>910</td><td>−3,700</td><td>±1,000</td><td>3.6</td><td>–</td><td>−10</td><td>−2</td></tr><tr><td>Austria</td><td>Jun 13, 2021</td><td>w</td><td>10,000</td><td>9,800</td><td>±1,400</td><td>7.0</td><td>0.9</td><td>110</td><td>12</td></tr><tr><td>Azerbaijan</td><td>Feb 28, 2021</td><td>m</td><td>3,200</td><td>18,000</td><td>±1,400</td><td>13.0</td><td>5.6</td><td>180</td><td>32</td></tr><tr><td>Belarus</td><td>Jun 30, 2020</td><td>m</td><td>390</td><td>5,700</td><td>±930</td><td>6.1</td><td>14.5</td><td>60</td><td>5</td></tr><tr><td>Belgium</td><td>Jun 13, 2021</td><td>w</td><td>25,000</td><td>16,000</td><td>±1,800</td><td>8.7</td><td>0.6</td><td>140</td><td>14</td></tr><tr><td>Bolivia</td><td>May 31, 2021</td><td>m</td><td>14,000</td><td>36,000</td><td>±770</td><td>46.4</td><td>2.5</td><td>310</td><td>68</td></tr><tr><td>Bosnia</td><td>Mar 31, 2021</td><td>m</td><td>6,600</td><td>8,900</td><td>±990</td><td>9.0</td><td>1.4</td><td>270</td><td>25</td></tr><tr><td>Brazil</td><td>May 31, 2021</td><td>m</td><td>460,000</td><td>500,000</td><td>±14,000</td><td>35.0</td><td>1.1</td><td>240</td><td>37</td></tr><tr><td>Bulgaria</td><td>Jun 20, 2021</td><td>w</td><td>18,000</td><td>32,000</td><td>±1,800</td><td>17.5</td><td>1.8</td><td>460</td><td>29</td></tr><tr><td>Canada</td><td>Mar 07, 2021</td><td>w</td><td>22,000</td><td>15,000</td><td>±1,700</td><td>8.6</td><td>0.7</td><td>40</td><td>5</td></tr><tr><td>Chile</td><td>Jun 13, 2021</td><td>w</td><td>31,000</td><td>30,000</td><td>±1,100</td><td>26.7</td><td>1.0</td><td>160</td><td>27</td></tr><tr><td>Colombia</td><td>May 09, 2021</td><td>w</td><td>77,000</td><td>92,000</td><td>±1,500</td><td>61.2</td><td>1.2</td><td>180</td><td>36</td></tr><tr><td>Costa Rica</td><td>Dec 31, 2020</td><td>m</td><td>2,200</td><td>940</td><td>±370</td><td>2.5</td><td>0.4</td><td>20</td><td>4</td></tr><tr><td>Croatia</td><td>May 30, 2021</td><td>w</td><td>8,000</td><td>8,800</td><td>±1,000</td><td>8.8</td><td>1.1</td><td>210</td><td>17</td></tr><tr><td>Cuba</td><td>Dec 31, 2020</td><td>m</td><td>150</td><td>580</td><td>±2,100</td><td>0.3</td><td>–</td><td>10</td><td>1</td></tr><tr><td>Cyprus</td><td>May 09, 2021</td><td>w</td><td>330</td><td>340</td><td>±160</td><td>2.1</td><td>1.0</td><td>30</td><td>5</td></tr><tr><td>Czechia</td><td>May 23, 2021</td><td>w</td><td>30,000</td><td>35,000</td><td>±1,800</td><td>18.8</td><td>1.2</td><td>320</td><td>30</td></tr><tr><td>Denmark</td><td>Jun 20, 2021</td><td>w</td><td>2,500</td><td>−630</td><td>±610</td><td>1.0</td><td>–</td><td>−10</td><td>−1</td></tr><tr><td>Ecuador</td><td>Jun 20, 2021</td><td>w</td><td>21,000</td><td>62,000</td><td>±960</td><td>64.4</td><td>2.9</td><td>350</td><td>80</td></tr><tr><td>Egypt</td><td>Nov 30, 2020</td><td>m</td><td>6,600</td><td>87,000</td><td>±13,000</td><td>6.9</td><td>13.1</td><td>90</td><td>16</td></tr><tr><td>El Salvador</td><td>Aug 31, 2020</td><td>m</td><td>720</td><td>4,700</td><td>±890</td><td>5.3</td><td>6.6</td><td>70</td><td>11</td></tr><tr><td>Estonia</td><td>Jun 27, 2021</td><td>w</td><td>1,300</td><td>1,800</td><td>±300</td><td>6.0</td><td>1.4</td><td>140</td><td>12</td></tr><tr><td>Finland</td><td>Jun 13, 2021</td><td>w</td><td>960</td><td>410</td><td>±680</td><td>0.6</td><td>0.4</td><td>10</td><td>1</td></tr><tr><td>France</td><td>Jun 13, 2021</td><td>w</td><td>110,000</td><td>72,000</td><td>±8,000</td><td>8.9</td><td>0.7</td><td>110</td><td>12</td></tr><tr><td>French Guiana</td><td>Jun 13, 2021</td><td>w</td><td>130</td><td>−20</td><td>±60</td><td>0.3</td><td>–</td><td>−10</td><td>−2</td></tr><tr><td>French Polynesia</td><td>Dec 31, 2020</td><td>m</td><td>110</td><td>120</td><td>±90</td><td>1.4</td><td>1.1</td><td>40</td><td>8</td></tr><tr><td>Georgia</td><td>Dec 31, 2020</td><td>m</td><td>2,500</td><td>4,800</td><td>±1,000</td><td>4.7</td><td>1.9</td><td>120</td><td>11</td></tr><tr><td>Germany</td><td>Jun 20, 2021</td><td>w</td><td>90,000</td><td>39,000</td><td>±17,000</td><td>2.3</td><td>0.4</td><td>50</td><td>4</td></tr><tr><td>Gibraltar</td><td>Jan 31, 2021</td><td>m</td><td>80</td><td>20</td><td>±20</td><td>1.1</td><td>0.3</td><td>70</td><td>7</td></tr><tr><td>Greece</td><td>May 02, 2021</td><td>w</td><td>10,000</td><td>7,500</td><td>±2,000</td><td>3.8</td><td>0.7</td><td>70</td><td>6</td></tr><tr><td>Greenland</td><td>Dec 31, 2020</td><td>m</td><td>0</td><td>−20</td><td>±30</td><td>0.5</td><td>–</td><td>−30</td><td>−3</td></tr><tr><td>Guadeloupe</td><td>Jun 13, 2021</td><td>w</td><td>260</td><td>220</td><td>±110</td><td>2.0</td><td>0.8</td><td>60</td><td>6</td></tr><tr><td>Guatemala</td><td>Dec 27, 2020</td><td>w</td><td>4,800</td><td>10,000</td><td>±700</td><td>14.5</td><td>2.1</td><td>60</td><td>12</td></tr><tr><td>Hong Kong</td><td>Mar 31, 2021</td><td>m</td><td>200</td><td>2,100</td><td>±1,100</td><td>1.9</td><td>–</td><td>30</td><td>4</td></tr><tr><td>Hungary</td><td>May 30, 2021</td><td>w</td><td>30,000</td><td>24,000</td><td>±2,300</td><td>10.2</td><td>0.8</td><td>240</td><td>18</td></tr><tr><td>Iceland</td><td>Mar 21, 2021</td><td>w</td><td>30</td><td>−20</td><td>±70</td><td>0.2</td><td>–</td><td>−0</td><td>−1</td></tr><tr><td>Iran</td><td>Sep 21, 2020</td><td>q</td><td>24,000</td><td>58,000</td><td>±7,900</td><td>7.3</td><td>2.4</td><td>70</td><td>15</td></tr><tr><td>Ireland</td><td>May 31, 2021</td><td>m</td><td>5,000</td><td>1,400</td><td>±730</td><td>1.9</td><td>0.3</td><td>30</td><td>4</td></tr><tr><td>Israel</td><td>May 30, 2021</td><td>w</td><td>6,400</td><td>4,800</td><td>±550</td><td>8.9</td><td>0.8</td><td>60</td><td>10</td></tr><tr><td>Italy</td><td>Apr 04, 2021</td><td>w</td><td>110,000</td><td>120,000</td><td>±9,000</td><td>13.9</td><td>1.1</td><td>210</td><td>19</td></tr><tr><td>Jamaica</td><td>Nov 30, 2020</td><td>m</td><td>260</td><td>−320</td><td>±310</td><td>1.0</td><td>–</td><td>−10</td><td>−2</td></tr><tr><td>Japan</td><td>Apr 30, 2021</td><td>m</td><td>10,000</td><td>−15,000</td><td>±12,000</td><td>1.3</td><td>–</td><td>−10</td><td>−1</td></tr><tr><td>Kazakhstan</td><td>Apr 30, 2021</td><td>m</td><td>6,600</td><td>35,000</td><td>±3,400</td><td>10.3</td><td>5.3</td><td>180</td><td>26</td></tr><tr><td>Kosovo</td><td>Mar 31, 2021</td><td>m</td><td>1,900</td><td>2,800</td><td>±310</td><td>8.9</td><td>1.5</td><td>150</td><td>30</td></tr><tr><td>Kyrgyzstan</td><td>Apr 30, 2021</td><td>m</td><td>1,600</td><td>7,900</td><td>±670</td><td>11.8</td><td>4.9</td><td>120</td><td>24</td></tr><tr><td>Latvia</td><td>Jun 13, 2021</td><td>w</td><td>2,500</td><td>3,000</td><td>±440</td><td>6.8</td><td>1.2</td><td>160</td><td>10</td></tr><tr><td>Lebanon</td><td>Apr 30, 2021</td><td>m</td><td>7,300</td><td>8,900</td><td>±970</td><td>9.2</td><td>1.2</td><td>130</td><td>36</td></tr><tr><td>Liechtenstein</td><td>Apr 30, 2021</td><td>m</td><td>60</td><td>50</td><td>±30</td><td>1.7</td><td>0.8</td><td>120</td><td>17</td></tr><tr><td>Lithuania</td><td>Jun 20, 2021</td><td>w</td><td>4,400</td><td>9,500</td><td>±600</td><td>15.9</td><td>2.2</td><td>350</td><td>25</td></tr><tr><td>Luxembourg</td><td>Jun 06, 2021</td><td>w</td><td>820</td><td>190</td><td>±140</td><td>1.4</td><td>0.2</td><td>30</td><td>4</td></tr><tr><td>Macao</td><td>Apr 30, 2021</td><td>m</td><td>0</td><td>−40</td><td>±110</td><td>0.3</td><td>–</td><td>−10</td><td>−2</td></tr><tr><td>Malaysia</td><td>Mar 31, 2021</td><td>m</td><td>1,300</td><td>−6,600</td><td>±1,900</td><td>3.5</td><td>–</td><td>−20</td><td>−4</td></tr><tr><td>Malta</td><td>May 16, 2021</td><td>w</td><td>420</td><td>360</td><td>±120</td><td>3.0</td><td>0.9</td><td>80</td><td>9</td></tr><tr><td>Martinique</td><td>Jun 13, 2021</td><td>w</td><td>100</td><td>30</td><td>±110</td><td>0.3</td><td>0.3</td><td>10</td><td>1</td></tr><tr><td>Mauritius</td><td>Apr 30, 2021</td><td>m</td><td>20</td><td>−440</td><td>±240</td><td>1.8</td><td>–</td><td>−30</td><td>−4</td></tr><tr><td>Mayotte</td><td>Jun 13, 2021</td><td>w</td><td>170</td><td>320</td><td>±50</td><td>6.5</td><td>1.8</td><td>120</td><td>40</td></tr><tr><td>Mexico</td><td>May 23, 2021</td><td>w</td><td>220,000</td><td>470,000</td><td>±6,600</td><td>70.1</td><td>2.1</td><td>360</td><td>61</td></tr><tr><td>Moldova</td><td>Mar 31, 2021</td><td>m</td><td>5,000</td><td>8,000</td><td>±880</td><td>9.0</td><td>1.6</td><td>200</td><td>22</td></tr><tr><td>Monaco</td><td>May 31, 2021</td><td>m</td><td>30</td><td>120</td><td>±50</td><td>2.5</td><td>3.7</td><td>300</td><td>24</td></tr><tr><td>Mongolia</td><td>May 31, 2021</td><td>m</td><td>280</td><td>−1,900</td><td>±490</td><td>3.9</td><td>–</td><td>−60</td><td>−11</td></tr><tr><td>Montenegro</td><td>Mar 28, 2021</td><td>w</td><td>1,200</td><td>1,400</td><td>±170</td><td>8.4</td><td>1.2</td><td>230</td><td>21</td></tr><tr><td>Netherlands</td><td>Jun 20, 2021</td><td>w</td><td>18,000</td><td>19,000</td><td>±1,900</td><td>9.8</td><td>1.1</td><td>110</td><td>12</td></tr><tr><td>New Zealand</td><td>Jun 06, 2021</td><td>w</td><td>30</td><td>−1,900</td><td>±410</td><td>4.7</td><td>–</td><td>−40</td><td>−5</td></tr><tr><td>Nicaragua</td><td>Aug 31, 2020</td><td>m</td><td>140</td><td>7,000</td><td>±270</td><td>26.0</td><td>50.8</td><td>100</td><td>27</td></tr><tr><td>North Macedonia</td><td>Apr 30, 2021</td><td>m</td><td>4,900</td><td>8,600</td><td>±770</td><td>11.3</td><td>1.8</td><td>420</td><td>43</td></tr><tr><td>Norway</td><td>Jun 20, 2021</td><td>w</td><td>790</td><td>−1,500</td><td>±530</td><td>2.9</td><td>–</td><td>−30</td><td>−4</td></tr><tr><td>Oman</td><td>May 31, 2021</td><td>m</td><td>2,300</td><td>2,200</td><td>±330</td><td>6.7</td><td>0.9</td><td>40</td><td>24</td></tr><tr><td>Panama</td><td>Apr 30, 2021</td><td>m</td><td>6,200</td><td>6,500</td><td>±420</td><td>15.7</td><td>1.0</td><td>150</td><td>31</td></tr><tr><td>Paraguay</td><td>May 31, 2021</td><td>m</td><td>9,100</td><td>9,600</td><td>±920</td><td>10.3</td><td>1.1</td><td>130</td><td>28</td></tr><tr><td>Peru</td><td>Jun 27, 2021</td><td>w</td><td>190,000</td><td>190,000</td><td>±2,000</td><td>95.9</td><td>1.0</td><td>590</td><td>153</td></tr><tr><td>Philippines</td><td>Dec 31, 2020</td><td>m</td><td>9,200</td><td>−7,700</td><td>±5,900</td><td>1.3</td><td>–</td><td>−10</td><td>−1</td></tr><tr><td>Poland</td><td>Jun 13, 2021</td><td>w</td><td>75,000</td><td>120,000</td><td>±5,500</td><td>21.1</td><td>1.6</td><td>310</td><td>28</td></tr><tr><td>Portugal</td><td>Jun 06, 2021</td><td>w</td><td>17,000</td><td>19,000</td><td>±2,100</td><td>9.0</td><td>1.1</td><td>180</td><td>16</td></tr><tr><td>Qatar</td><td>Apr 30, 2021</td><td>m</td><td>460</td><td>650</td><td>±70</td><td>9.2</td><td>1.4</td><td>20</td><td>29</td></tr><tr><td>Romania</td><td>Apr 25, 2021</td><td>w</td><td>31,000</td><td>54,000</td><td>±3,500</td><td>15.3</td><td>1.7</td><td>280</td><td>20</td></tr><tr><td>Russia</td><td>Apr 30, 2021</td><td>m</td><td>110,000</td><td>500,000</td><td>±33,000</td><td>15.2</td><td>4.5</td><td>340</td><td>28</td></tr><tr><td>Réunion</td><td>Jun 13, 2021</td><td>w</td><td>210</td><td>190</td><td>±130</td><td>1.5</td><td>0.9</td><td>20</td><td>4</td></tr><tr><td>San Marino</td><td>May 31, 2021</td><td>m</td><td>90</td><td>110</td><td>±30</td><td>3.4</td><td>1.2</td><td>320</td><td>42</td></tr><tr><td>Serbia</td><td>May 31, 2021</td><td>m</td><td>6,900</td><td>28,000</td><td>±3,600</td><td>7.7</td><td>4.0</td><td>400</td><td>27</td></tr><tr><td>Seychelles</td><td>Dec 31, 2020</td><td>m</td><td>0</td><td>−170</td><td>±40</td><td>4.1</td><td>–</td><td>−170</td><td>−20</td></tr><tr><td>Singapore</td><td>Mar 31, 2021</td><td>m</td><td>30</td><td>−160</td><td>±380</td><td>0.4</td><td>–</td><td>−0</td><td>−1</td></tr><tr><td>Slovakia</td><td>May 16, 2021</td><td>w</td><td>12,000</td><td>17,000</td><td>±920</td><td>18.1</td><td>1.4</td><td>310</td><td>30</td></tr><tr><td>Slovenia</td><td>May 23, 2021</td><td>w</td><td>4,700</td><td>3,700</td><td>±370</td><td>10.0</td><td>0.8</td><td>180</td><td>17</td></tr><tr><td>South Africa</td><td>Jun 27, 2021</td><td>w</td><td>60,000</td><td>160,000</td><td>±nan</td><td>nan</td><td>2.7</td><td>270</td><td>32</td></tr><tr><td>South Korea</td><td>May 02, 2021</td><td>w</td><td>1,800</td><td>−3,300</td><td>±2,900</td><td>1.1</td><td>–</td><td>−10</td><td>−1</td></tr><tr><td>Spain</td><td>Jun 20, 2021</td><td>w</td><td>81,000</td><td>87,000</td><td>±6,300</td><td>13.9</td><td>1.1</td><td>190</td><td>20</td></tr><tr><td>Sweden</td><td>Jun 06, 2021</td><td>w</td><td>15,000</td><td>8,900</td><td>±1,100</td><td>8.5</td><td>0.6</td><td>90</td><td>10</td></tr><tr><td>Switzerland</td><td>Jun 06, 2021</td><td>w</td><td>10,000</td><td>8,600</td><td>±1,100</td><td>8.0</td><td>0.8</td><td>100</td><td>13</td></tr><tr><td>Taiwan</td><td>May 31, 2021</td><td>m</td><td>140</td><td>−6,600</td><td>±5,700</td><td>1.2</td><td>–</td><td>−30</td><td>−4</td></tr><tr><td>Tajikistan</td><td>Dec 31, 2020</td><td>q</td><td>90</td><td>9,000</td><td>±1,400</td><td>6.6</td><td>100.0</td><td>90</td><td>27</td></tr><tr><td>Thailand</td><td>Jun 30, 2021</td><td>m</td><td>2,100</td><td>14,000</td><td>±13,000</td><td>1.1</td><td>–</td><td>20</td><td>3</td></tr><tr><td>Transnistria</td><td>May 31, 2021</td><td>m</td><td>1,200</td><td>1,600</td><td>±240</td><td>6.4</td><td>1.3</td><td>340</td><td>23</td></tr><tr><td>Tunisia</td><td>Feb 14, 2021</td><td>w</td><td>7,500</td><td>4,600</td><td>±1,100</td><td>4.3</td><td>0.6</td><td>40</td><td>6</td></tr><tr><td>Ukraine</td><td>Apr 30, 2021</td><td>m</td><td>44,000</td><td>81,000</td><td>±13,000</td><td>6.4</td><td>1.8</td><td>200</td><td>14</td></tr><tr><td>United Kingdom</td><td>Jun 13, 2021</td><td>w</td><td>130,000</td><td>110,000</td><td>±9,200</td><td>11.9</td><td>0.9</td><td>160</td><td>18</td></tr><tr><td>United States</td><td>Jun 06, 2021</td><td>w</td><td>590,000</td><td>640,000</td><td>±16,000</td><td>38.9</td><td>1.1</td><td>190</td><td>22</td></tr><tr><td>Uruguay</td><td>Dec 31, 2020</td><td>m</td><td>170</td><td>−2,200</td><td>±710</td><td>3.2</td><td>–</td><td>−60</td><td>−6</td></tr><tr><td>Uzbekistan</td><td>Mar 31, 2021</td><td>m</td><td>630</td><td>20,000</td><td>±3,900</td><td>5.0</td><td>31.5</td><td>60</td><td>13</td></tr></tbody></table></table-wrap><p>In terms of the absolute numbers, the largest excess mortality in our dataset was observed in the United States (640,000 by June 6, 2021; all reported numbers here and below have been rounded to two significant digits), Brazil (500,000 by May 31, 2021), Russia (500,000 by April 30, 2021), and Mexico (470,000 by May 23, 2021) (<xref ref-type="fig" rid="fig3">Figure 3</xref>). Note that these estimates correspond to different time points as the reporting lags differ between countries (<xref ref-type="table" rid="table1">Table 1</xref>). See <xref ref-type="fig" rid="fig3s1">Figure 3—figure supplement 1</xref> for the same analysis using the 2020 data alone.</p><fig-group><fig id="fig3" position="float"><label>Figure 3.</label><caption><title>Top 10 countries in the World Mortality Dataset by various excess mortality measures.</title><p>Each subplot shows the top 10 countries for each of our four excess mortality measures: total number of excess deaths; excess deaths per 100,000 population; excess deaths as a percentage of baseline annual mortality; undercount ratio (ratio of excess deaths to reported COVID-19 deaths by the same date). Error bars denote 95% confidence intervals corresponding to the uncertainty of the excess deaths estimate. Countries with population below 500,000 are not shown. Different countries have different reporting lags, so the estimates shown here correspond to different time points, as indicated. Excess mortality estimates in Armenia and Azerbaijan were downwards corrected by 4000 to account for the war casualties (see Materials and methods).</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig3-v3.tif"/></fig><fig id="fig3s1" position="float" specific-use="child-fig"><label>Figure 3—figure supplement 1.</label><caption><title>Top 10 countries in the World Mortality Dataset by various excess mortality measures by the end of 2020.</title><p>Each subplot shows the top 10 countries for each of our four excess mortality measures: total number of excess deaths; excess deaths per 100,000 population; excess deaths as a percentage of baseline annual mortality; undercount ratio (ratio of excess deaths to reported COVID-19 deaths by the same date). Error bars denote 95% confidence intervals corresponding to the uncertainty of the excess deaths estimate. Countries with population below 500,000 are not shown. Excess mortality estimates in Armenia and Azerbaijan were downwards corrected by 4000 to account for the war casualties (see Materials and mthods).</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig3-figsupp1-v3.tif"/></fig></fig-group><p>Some countries showed statistically significant negative excess mortality, likely due to lockdown measures and social distancing decreasing the prevalence of influenza (<xref ref-type="bibr" rid="bib37">Kung et al., 2021</xref>), as we discuss further below. For example, Australia had −3,700 excess deaths, Uruguay had −2,200 deaths, and New Zealand had −1,900 deaths. In these three cases, the decrease in mortality happened during the southern hemisphere winter season (<xref ref-type="fig" rid="fig2">Figure 2</xref>). Similarly, Norway had −1,500 excess deaths, with most of this decrease happening during the 2020/21 winter season. Note that Uruguay had a large COVID outbreak in 2021, but we only have 2020 data available at the time of writing. The statistically significant mortality decrease in Malaysia, Mongolia, and Seychelles may also be related to the lockdown and social distancing measures but does not show clear seasonality, so may possibly also be due to other factors.</p><p>As the raw number of excess deaths can be strongly affected by the country’s population size, we normalized the excess mortality estimates by the population size (<xref ref-type="table" rid="table1">Table 1</xref>). The highest excess mortality per 100,000 inhabitants was observed in Peru (590), followed by some Eastern European and then Latin American countries: Bulgaria (460), North Macedonia (420), Serbia (400), Mexico (360), Ecuador (350), Lithuania (350), Russia (340), etc. (<xref ref-type="fig" rid="fig3">Figure 3</xref>). Note that many countries with severe outbreaks that received wide international media attention, such as Italy, Spain, and United Kingdom, had lower values (<xref ref-type="table" rid="table1">Table 1</xref>).</p><p>The infection-fatality rate (IFR) of COVID-19 is strongly age-dependent (<xref ref-type="bibr" rid="bib42">Levin et al., 2020</xref>; <xref ref-type="bibr" rid="bib53">O’Driscoll et al., 2021</xref>). As the countries differ in their age structure, the expected overall IFR differs between countries. To account for the age structure, we also normalized the excess mortality estimates by the annual sum of the baseline mortality, that is the expected number of deaths per year without a pandemic event (<xref ref-type="table" rid="table1">Table 1</xref>). This relative increase, also known as a <italic>P-score</italic> (<xref ref-type="bibr" rid="bib6">Aron and Muellbauer, 2020</xref>), was by far the highest in Latin America: Peru (153%), Ecuador (80%), Bolivia (68%), and Mexico (61%) (<xref ref-type="fig" rid="fig3">Figure 3</xref>). These Latin American countries have much younger populations compared to the European and North American countries, which is why the excess mortality per 100,000 inhabitants there was lower than in several Eastern European countries, but the relative increase in mortality was higher, suggesting higher COVID-19 prevalence. That the highest relative mortality increase was observed in Peru, is in agreement with some parts of Peru showing the highest measured seroprevalence level in the world (<xref ref-type="bibr" rid="bib5">Álvarez-Antonio et al., 2021</xref>).</p></sec><sec id="s2-2"><title>Undercount of COVID deaths</title><p>For each country, we computed the ratio of the excess mortality to the officially reported COVID-19 death count by the same date. This ratio differed very strongly between countries (<xref ref-type="table" rid="table1">Table 1</xref>). Some countries had ratio below 1, for example 0.7 in France and 0.6 in Belgium, where reporting of COVID deaths is known to be very accurate (<xref ref-type="bibr" rid="bib58">Sierra et al., 2020</xref>). The likely reason is that the non-COVID mortality has decreased, mostly due to the influenza suppression (see below), leading to the excess mortality underestimating the true number of COVID deaths.</p><p>Nevertheless, many countries had ratios above 1, suggesting an undercount of COVID-19 deaths (<xref ref-type="bibr" rid="bib9">Beaney et al., 2020</xref>). At the same time, correlation between weekly reported COVID-19 deaths and weekly excess deaths was often very high (<xref ref-type="fig" rid="fig4">Figure 4</xref>): e.g. in Mexico (undercount ratio 2.1) correlation was <inline-formula><mml:math id="inf4"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.80</mml:mn></mml:mrow></mml:mstyle></mml:math></inline-formula> and in South Africa (undercount ratio 2.7) it was <inline-formula><mml:math id="inf5"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.93</mml:mn></mml:mrow></mml:mstyle></mml:math></inline-formula>. High correlations suggest that excess mortality during a COVID outbreak can be fully explained by COVID-19 mortality, even when the latter is strongly underreported. Peru deserves a special mention: until early June, the undercount ratio in Peru was 2.7, with correlation <inline-formula><mml:math id="inf6"><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.87</mml:mn></mml:mrow></mml:math></inline-formula>. Peru changed the definition of reported ‘COVID deaths’ to be more inclusive and submitted backwards revisions to WHO (<xref ref-type="bibr" rid="bib45">Ministry of Health, 2021</xref>); as a result, the undercount ratio dropped to 1.0 and correlation increased to <inline-formula><mml:math id="inf7"><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.99</mml:mn></mml:mrow></mml:math></inline-formula> (<xref ref-type="fig" rid="fig4">Figure 4</xref>). This example clearly illustrates that undercount ratios above 1.0 primarily arise from undercounting deaths from COVID infections. See Discussion for additional considerations.</p><fig id="fig4" position="float"><label>Figure 4.</label><caption><title>Relation between weekly excess deaths and weekly reported COVID-19 deaths.</title><p>Sixteen selected countries are shown together with the Pearson correlation coefficient (<inline-formula><mml:math id="inf8"><mml:mi>r</mml:mi></mml:math></inline-formula>) between the two time series, starting from week 10 of 2020. Note the peak in excess mortality (but not in the reported COVID-19 deaths) associated with the August 2020 heat wave in Belgium, France, Germany, and Netherlands.</p></caption><graphic mime-subtype="tiff" mimetype="image" xlink:href="elife-69336-fig4-v3.tif"/></fig><p>Interestingly, in many countries, the undercount ratio was not constant across time. For example, the undercount ratio in Italy, Spain, Netherlands, and United Kingdom was ∼1.5 during the first wave (<xref ref-type="fig" rid="fig4">Figure 4</xref>), but decreased to ∼1.0 during the second wave. This decrease of the undercount ratio may be partially due to improved COVID death reporting, and partially due to the excess mortality underestimating the true COVID mortality in winter seasons due to influenza suppression.</p><p>On the other hand, several countries showed very accurate reporting of the COVID-19 deaths with the undercount ratio being close to 1.0 (<xref ref-type="bibr" rid="bib58">Sierra et al., 2020</xref>) from the beginning of the pandemic and up until the middle of the second wave (e.g. Austria, Belgium, France, Germany, Slovenia, Sweden; <xref ref-type="fig" rid="fig4">Figure 4</xref>). However, starting from December 2020 and up until March–April 2021 the excess deaths were underestimating the COVID-19 deaths in all these countries. The difference between the officially reported COVID-19 deaths and the excess deaths may correspond to the number of deaths typically caused by influenza and other infectious respiratory diseases in winter months. This difference (computed starting from week 40 of 2020 and until week 15 of 2021), as a fraction of baseline annual deaths, was in the 2.3–5.9% range (Austria: 2.3%, Belgium: 5.9%, France: 4.3%, Germany: 3.9%, Slovenia: 3.5%, Sweden: 5.5%). This is in good agreement with the total negative excess deaths observed in Australia, New Zealand, Uruguay, and Norway (−2.5%, −5.4%, −6.4%, −3.7%) and coming mainly from the Southern and Northern hemisphere winter months respectively (<xref ref-type="bibr" rid="bib37">Kung et al., 2021</xref>). Per 100,000 inhabitants, the same difference was in the 20–60 range.</p><p>The undercount ratio for most countries was below 3.0 (<xref ref-type="table" rid="table1">Table 1</xref>), but some countries showed much larger values. We found the highest undercount ratios in Tajikistan (100), Nicaragua (51), Uzbekistan (31), Belarus (14), and Egypt (13) (<xref ref-type="fig" rid="fig3">Figure 3</xref>). Such large undercount ratios strongly suggest purposeful misdiagnosing or underreporting of COVID-19 deaths, as argued by <xref ref-type="bibr" rid="bib33">Kobak, 2021a</xref> for the case of Russia (undercount ratio 4.5).</p></sec></sec><sec id="s3" sec-type="discussion"><title>Discussion</title><sec id="s3-1"><title>Summary</title><p>We presented the World Mortality Dataset — the largest international dataset of all-cause mortality, currently encompassing 103 countries. The dataset is openly available and regularly updated. We are committed to keep maintaining this dataset for the entire duration of the COVID-19 pandemic.</p><p>The coverage and reliability of the data varies across countries, and some of the countries in our dataset may possibly report incomplete mortality numbers (e.g. covering only part of the country), see caveats in the Data limitations and caveats section of Materials and methods. This would make the excess mortality estimate during the COVID-19 outbreak incomplete (as an example, <xref ref-type="bibr" rid="bib43">Lloyd-Sherlock et al., 2021</xref> estimate that the true excess mortality in Peru may be 30% higher than excess mortality computed here due to incomplete death registration in Peru). Importantly, the early pre-outbreak 2020 data for all countries in our dataset matched the baseline obtained from the historic 2015–2019 data, indicating that the data are self-consistent and the excess mortality estimates are not inflated. Another important caveat is that the most recent data points in many countries tend to be incomplete and can experience upwards revisions. Both factors mean that some of the excess mortality estimates reported here may be underestimations.</p><p>Some of the countries in our dataset have excess death estimates available in the constantly evolving literature on excess deaths during the COVID-19 pandemic from academia, official institutions and professional associations. The largest efforts include the analysis of STMF data (<xref ref-type="bibr" rid="bib35">Kontis et al., 2020</xref>; <xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>) and excess mortality trackers by <italic>The Economist</italic> and <italic>Financial Times</italic>. While the analysis is similar everywhere and the estimates broadly agree, there are many possible modeling choices (the start date and the end date of the total excess computation; including or excluding historic influenza waves when computing the baseline; modeling trend over years or not, etc.) making all the estimates slightly different.</p></sec><sec id="s3-2"><title>Contributions to excess mortality</title><p>Conceptually, excess mortality during the COVID-19 pandemic can be represented as the sum of several distinct factors:<disp-formula id="equ1"><mml:math id="m1"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mtable columnalign="right left right left right left right left right left right left" columnspacing="0em 2em 0em 2em 0em 2em 0em 2em 0em 2em 0em" displaystyle="true" rowspacing="3pt"><mml:mtr><mml:mtd><mml:mrow><mml:mi mathvariant="normal">E</mml:mi><mml:mi mathvariant="normal">x</mml:mi><mml:mi mathvariant="normal">c</mml:mi><mml:mi 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mathvariant="normal">s</mml:mi><mml:mi mathvariant="normal">t</mml:mi><mml:mi mathvariant="normal">e</mml:mi><mml:mi mathvariant="normal">r</mml:mi><mml:mi mathvariant="normal">s</mml:mi><mml:mo>,</mml:mo><mml:mspace width="thickmathspace"/><mml:mi mathvariant="normal">e</mml:mi><mml:mi mathvariant="normal">t</mml:mi><mml:mi mathvariant="normal">c</mml:mi><mml:mo>.</mml:mo></mml:mrow></mml:mtd></mml:mtr></mml:mtable></mml:mrow></mml:mstyle></mml:math></disp-formula></p><p>We explicitly account for factor (E) and argue that for most countries, the contribution of factors (B)–(D) is small in comparison to factor (A), in agreement with the view that excess mortality during an epidemic outbreak can be taken as a proxy for COVID-19 mortality (<xref ref-type="bibr" rid="bib9">Beaney et al., 2020</xref>). Below we discuss each of the listed factors.</p><p>It is possible that when a country experiences a particularly strong COVID outbreak, deaths from non-COVID causes also increase due to the medical system being overloaded — factor (B) above. Our data show that this did not happen in Belgium (undercount ratio during the first wave was close to 1.0, i.e. all excess deaths were due to COVID-19 infections), despite a ∼100% weekly increase in all-cause mortality. Moreover, our data suggest that this did not happen in Peru, during one of the strongest registered COVID outbreaks in the world until now: despite ∼200% weekly increase in all-cause mortality, undercount ratio stayed close to 1.0 (after Peru revised the number of reported COVID deaths, see above). Even if deaths due to other diseases did increase, then such collateral excess deaths can nevertheless be seen as indirect consequence of COVID-19 outbreaks. However, the available data suggest that this factor, if at all, plays only a minor role in the overall excess deaths.</p><p>The data suggest that the contribution of factor (C) to the excess mortality is negative. Indeed, countries that implemented stringent lockdown and social distancing measures in the absence of COVID-19 community spread, such as Australia, New Zealand, and Uruguay, showed a clear winter-season decrease in all-cause mortality, likely due to reduced influenza transmission (<xref ref-type="bibr" rid="bib37">Kung et al., 2021</xref>). Here, using these three countries as well as some of the European data, we estimated that the influenza suppression alone can lead to a decrease of annual mortality by 3–6%. Other infectious diseases may also be suppressed by enforced social distancing. For example, in South Africa, lockdowns have noticeably decreased toddler mortality (0–4 years) (<xref ref-type="bibr" rid="bib13">Bradshaw et al., 2021</xref>). This effect was not observed in the developed countries where toddler mortality is low (<xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>), but could be present in other developing countries as well.</p><p>The effect of factor (D) appears to be country-specific. Traffic accident fatalities have decreased in the European Union and the Western Balkans (<xref ref-type="bibr" rid="bib18">European Commission, 2021</xref>; <xref ref-type="bibr" rid="bib64">Transport Community, 2021</xref>) but have increased in the United States (<xref ref-type="bibr" rid="bib50">National Safety Council, 2021</xref>). Homicides have increased in the United States (<xref ref-type="bibr" rid="bib7">Arthur and Asher, 2020</xref>; <xref ref-type="bibr" rid="bib22">Faust et al., 2021</xref>) and Germany (<xref ref-type="bibr" rid="bib23">Federal Criminal Police Office, 2021</xref>) but have decreased in Peru (<xref ref-type="bibr" rid="bib14">Calderon-Anyosa and Kaufman, 2021</xref>), South Africa (<xref ref-type="bibr" rid="bib13">Bradshaw et al., 2021</xref>), and France (<xref ref-type="bibr" rid="bib46">Ministry of the Interior, 2021</xref>). Suicides have first decreased and then increased in Japan, particularly in females (<xref ref-type="bibr" rid="bib38">Kurita et al., 2021</xref>; <xref ref-type="bibr" rid="bib62">Tanaka and Okamoto, 2021</xref>; <xref ref-type="bibr" rid="bib10">Black and Kutcher, 2021</xref>), have decreased in the United States (<xref ref-type="bibr" rid="bib2">Ahmad and Anderson, 2021</xref>; <xref ref-type="bibr" rid="bib22">Faust et al., 2021</xref>), and in a study of 21 countries were found to have decreased in half of them and remained unchanged in the rest (<xref ref-type="bibr" rid="bib55">Pirkis et al., 2021</xref>). In the United States, deaths from drug overdoses and unintentional injuries have increased (<xref ref-type="bibr" rid="bib22">Faust et al., 2021</xref>). However, importantly, in all cited studies the combined effect of all changes in the frequency of unnatural changes did not exceed ∼1% of the baseline annual mortality, meaning that factor (D) plays only a minor role in excess mortality.</p><p>Finally, factor (E) in 2020–2021 was mostly constrained to the Nagorno-Karabakh war between Armenia and Azerbaijan and the August 2020 heat wave in Europe, which we explicitly accounted for. We could have possibly missed some other similar events in other countries, but we believe they could only play a minor role compared to COVID-19, thanks to the absence of other major wars or natural disasters in 2020–2021 in the countries included in our dataset.</p><p>Together, the evidence suggests that the contribution of factor (C) is negative and contribution of factor (D) is small in comparison, so we believe that lockdown and social distancing measures on their own decrease — and not increase — the death rate, at least in short-term. The contribution of factor (B), at least in developed countries, appears to be small, and so, in the absence of wars and natural disasters, one can expect excess mortality to provide a lower bound on the true number of COVID-19 deaths. In other words, we speculate that whenever COVID deaths are counted perfectly, they should exceed the excess mortality, leading to undercount ratio below 1. This is indeed what we observed in several countries with strong COVID-19 outbreaks but accurate accounting of COVID deaths, for example Belgium, France, and Germany (undercount ratios 0.6, 0.7, and 0.4, respectively).</p></sec><sec id="s3-3"><title>Conclusions and outlook</title><p>The World Mortality Dataset is open for researchers and policy makers from all fields. Avenues for future research include the relation between various measures of excess mortality and economic development, population structure, lockdown and social distancing measures, border controls and travel restrictions (<xref ref-type="bibr" rid="bib29">Hale et al., 2020</xref>), properties of the health-care systems, vaccinations, institutional quality (e.g. the Democracy Index), climate, geography, population density, and many more. Conversely, future research can use excess mortality estimates to study negative social or economic impact of high COVID-19 death toll.</p><p>So far we were able to collect data from 103 nations out of ∼200, with particularly sparse coverage in Africa, Asia, and the Middle East (<xref ref-type="fig" rid="fig1">Figure 1</xref>). During the pandemic, many countries have sped up collection and dissemination of preliminary all-cause mortality data, yet many other countries did not, and will report 2020 information with a substantial lag, in the coming months or even years. Once released, this information will be included in the World Mortality Dataset. Unfortunately, many countries do not keep reliable vital statistics and excess mortality may remain unknown for a long time.</p><p>Summing up the excess mortality estimates across all countries in our dataset gives 4.0 million excess deaths. In contrast, summing up the official COVID-19 death counts gives 2.9 million deaths, corresponding to the global undercount ratio of 1.4. However, there is ample evidence that among the countries for which the all-cause mortality data are not available the undercount ratio is much higher (<xref ref-type="bibr" rid="bib69">Watson et al., 2020</xref>; <xref ref-type="bibr" rid="bib16">Djaafara et al., 2021</xref>; <xref ref-type="bibr" rid="bib70">Watson et al., 2021</xref>; <xref ref-type="bibr" rid="bib49">Mwananyanda et al., 2021</xref>; <xref ref-type="bibr" rid="bib36">Koum Besson et al., 2021</xref>; <xref ref-type="bibr" rid="bib40">Leffler, 2021</xref>). Using a statistical model to predict the excess mortality in the rest of the world based on the existing data from our dataset, <italic>The Economist</italic> in May 2021 estimated 7–13 million excess deaths worldwide (<xref ref-type="bibr" rid="bib63">The Economist, 2021</xref>), which was 2–4 times higher than the world’s official COVID-19 death count at the time (3.5 million).</p><p>In conclusion, the COVID-19 pandemic highlighted the great importance of reliable and up-to-date all-cause mortality data. Just as countries around the world collect and regularly report estimates of economic output such as the gross domestic product (GDP), and just as they have been reporting COVID-19 mortality, they should be reporting all-cause mortality into a comprehensive multi-national repository (<xref ref-type="bibr" rid="bib41">Leon et al., 2020</xref>).</p></sec></sec><sec id="s4" sec-type="materials|methods"><title>Materials and methods</title><sec id="s4-1"><title>World Mortality Dataset</title><p>For all countries that are not covered by EuroStat or STMF, we aimed to collect weekly, monthly, or quarterly all-cause mortality data from their National Statistics Offices (NSOs), Population Registries, Ministries of Health, Ministries of Public Health, etc., collectively referred to here as ‘NSOs’.</p><p>Our strategy was to search for mortality numbers for every country on their NSO’s website. The data may be present in the form of a spreadsheet, a table generator, a periodical bulletin, a press release, a figure that required digitizing, etc. If we were unable to locate such data, we contacted the NSO via email, a contact form on their website, or on social media, asking them if they have weekly, monthly, or quarterly data on all-cause mortality for 2020.</p><p>Responses from NSOs have varied substantially. Some have provided us with the requested information, some replied that no such data were available, some did not respond at all. For many countries, the email addresses did not work and returned an error message. Here are some representative examples of the declining responses: ‘‘We are sorry to inform you that we do not have the data you requested’’ (China); ‘‘These are not available’’ (India); ‘‘Unfortunately we don’t have this data. Currently, we only have the number of people dying from traffic accidents (by month)’’ (Vietnam); ‘‘Unfortunately, we do not have a mechanism in place at the moment to capture routine mortality data in-country nation-wide […] As you may also be aware, death or mortality registration or reporting is yet a huge challenge in developing countries […]’’ (Liberia).</p><p>We included the data from 2015 onwards into our dataset if it satisfied the following inclusion criteria: (1) data were in weekly, monthly, or quarterly format (we preferred weekly data whenever available); (2) data existed at least until June 2020; (3) there were data for at least one entire year before 2020 (or a forecast for 2020, see below). At the time of writing, our dataset comprises 103 countries and territories (<xref ref-type="fig" rid="fig1">Figure 1</xref>).</p><p>For the weekly data, we preferred ISO weeks whenever possible (for Peru, Sweden, Ecuador, and Guatemala we converted daily data into ISO weeks). For Liechtenstein and Taiwan we preferred monthly format over weekly data from STMF/EuroStat, because weekly data were very noisy or less up-to-date. The data for Iran are available in quarterly format, where quarters start on December 21, March 21, June 21, and September 21 (Solar Hijri seasons). We treated the season starting on December 21 as the first data point for the following year.</p><p>Unlike STMF (<xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>), we only collected country-level data, without age or gender stratification, since for most countries this information was not available. In some cases, we had to combine several data sources, for example taking the 2015–2018 monthly data from UNDATA and 2019–2020 monthly data from a country’s NSO. For two countries (Gibraltar and Nicaragua) some of the values were taken from media reports which in turn obtained them from the respective NSOs. Some data points for Cuba and Uruguay were taken from <xref ref-type="bibr" rid="bib15">Castanheira et al., 2021</xref> and the data for Argentina from <xref ref-type="bibr" rid="bib56">Rearte et al., 2021</xref>. A detailed description of all data sources for each country can be found at <ext-link ext-link-type="uri" xlink:href="https://github.com/akarlinsky/world_mortality">https://github.com/akarlinsky/world_mortality</ext-link>. </p><p>In this manuscript, we treat Taiwan, Hong Kong, and Macao as separate countries. They release monthly all-cause mortality data, whereas China does not. We also treat Gibraltar, Greenland, and Transnistria as separate territories as the United Kingdom, Denmark, and Moldova do not report these deaths in their figures. Similarly, the French overseas departments of French Guiana, Guadeloupe, Martinique, Mayotte, and Réunion, the French overseas collectivity of French Polynesia, and Aruba, a constituent country of the Kingdom of the Netherlands, are included as separate territories as France and Netherlands do not report these deaths in their figures.</p></sec><sec id="s4-2"><title>Data limitations and caveats</title><p>The data in our dataset come with several important caveats.</p><p>First, the 2020–2021 data are often preliminary and subject to backward revisions. The more recent the data point, the more incomplete it usually is. Some countries only publish complete data (with a substantial delay) while others release very early and incomplete data as well. We excluded the most recent data points whenever there was an indication that the data were substantially incomplete. For the United States, we used the ‘weighted’ mortality counts from the Centers for Disease Control and Prevention (CDC) that account for undercount in recent weeks, instead of the STMF data.</p><p>Second, the completeness and reliability of all-cause mortality data varies by country. According to the United Nations Demographic Yearbook (<xref ref-type="bibr" rid="bib65">UNSD, 2019</xref>), 83 of the countries in our dataset have a death registration coverage rate of 90% and above. In the remaining 20 countries, coverage is either estimated to be below 90% (e.g. Peru, Ecuador, Bolivia) or no estimate exists at all (Kosovo, Taiwan, Transnistria). However, some of the available coverage estimates are outdated. For example, the estimate for Bolivia is from 2000. The estimate for Peru is from 2015, that is before the SINADEF reform in 2016 (<xref ref-type="bibr" rid="bib66">Vargas-Herrera et al., 2018</xref>) which has likely substantially improved the coverage. For Taiwan, Human Mortality Database estimates that the data are over 99% complete. At the same time, note that the coverage estimates refer to the finalized data so preliminary 2020–21 data may be less complete, as explained above. It is also possible that COVID-19 pandemic could have affected the quality of the vital registration.</p><p>Third, whereas we preferred data by date of death, the data from many countries are only available by the date of registration. Most weekly data are by the date of death (one notable exception is United Kingdom), but monthly data are often by the date of registration. Whenever the data are organized by the date of registration, it will show spurious drops in weeks or months with public holidays (e.g. last week of August and last week of December in the United Kingdom) or during national lockdowns (e.g. April 2020 in Kyrgyzstan, Kazakhstan, and Panama).</p><p>Fourth, we aimed to collect information from all countries from 2015 onward, yet currently we only have later data for four countries: Chile (2016), Germany (2016), Transnistria (2016), Peru (2017). Two other countries, South Africa and Argentina, did not release any pre-2020 data at all, but instead published a forecast for 2020 based on the prior data (<xref ref-type="bibr" rid="bib13">Bradshaw et al., 2021</xref>; <xref ref-type="bibr" rid="bib56">Rearte et al., 2021</xref>). We included this published forecast into the dataset as year 0.</p><p>Fifth, for most countries, the data are provided as-is, but for three countries (Brazil, Lebanon, and Sweden) we performed some processing to assure consistency across years, resulting in non-integer values. In Brazil, there are two mortality monitoring systems: ‘Registro Civil’ (RC) and ‘Sistema de Informaçāo sobre Mortalidade’ (SIM). RC is more up-to-date, whereas SIM is more complete. We used the SIM data up until October 2020 and RC data afterwards, multiplied by the ratio between total January–October 2020 deaths in SIM and in RC (1.08). Lebanon has reported total deaths from 2015 to 2019 and hospital deaths from 2017 to 2021. Total deaths in 2020–2021 were estimated by multiplying the hospital deaths by the ratio between total deaths in 2019 to hospital deaths in 2019 (1.34). Sweden has a substantial number of deaths (2.9% of all deaths in 2019; 2.7% in 2020) reported with an ‘unknown’ week. However, ∼95% of these have a known month of death. In order to account for this, we redistributed deaths with known month but unknown week uniformly across weeks of the respective month, and similarly redistributed the remaining deaths with known year but unknown month.</p><p>Despite the caveats and limitations listed above, all our data are self-consistent: the baseline mortality that we predict for 2020 agrees very well with the pre-COVID early 2020 mortality in all cases. Note that our projection for 2020 uses a linear trend (see below) and so can implicitly account for improvements in death registration over the recent years. We therefore believe that for countries with incomplete death registration coverage, our excess mortality estimates provide a lower bound to the true excess mortality.</p></sec><sec id="s4-3"><title>Excess mortality</title><p>In order to estimate the excess mortality, we first estimated the expected, or baseline, mortality for 2020 using the historical data from 2015 to 2019 (or as many years from this interval as were available; see above). We fitted the following regression model separately for each country:<disp-formula id="equ2"><label>(1)</label><mml:math id="m2"><mml:mrow><mml:mrow><mml:msub><mml:mi>D</mml:mi><mml:mrow><mml:mi>t</mml:mi><mml:mo>,</mml:mo><mml:mi>Y</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mrow><mml:msub><mml:mi>α</mml:mi><mml:mi>t</mml:mi></mml:msub><mml:mo>+</mml:mo><mml:mrow><mml:mi>β</mml:mi><mml:mo>⋅</mml:mo><mml:mi>Y</mml:mi></mml:mrow><mml:mo>+</mml:mo><mml:mi>ϵ</mml:mi></mml:mrow></mml:mrow><mml:mo>.</mml:mo></mml:mrow></mml:math></disp-formula></p><p>Here, <inline-formula><mml:math id="inf9"><mml:msub><mml:mi>D</mml:mi><mml:mrow><mml:mi>t</mml:mi><mml:mo>,</mml:mo><mml:mi>Y</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> is the number of deaths observed on week (or month, or quarter) <inline-formula><mml:math id="inf10"><mml:mi>t</mml:mi></mml:math></inline-formula> in year <inline-formula><mml:math id="inf11"><mml:mi>Y</mml:mi></mml:math></inline-formula>, <inline-formula><mml:math id="inf12"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:mstyle></mml:math></inline-formula> is a linear slope across years, <inline-formula><mml:math id="inf13"><mml:msub><mml:mi>α</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> are separate intercepts (fixed effects) for each week (month/quarter), and <inline-formula><mml:math id="inf14"><mml:mrow><mml:mi>ϵ</mml:mi><mml:mo>∼</mml:mo><mml:mrow><mml:mi class="ltx_font_mathcaligraphic">𝒩</mml:mi><mml:mo>⁢</mml:mo><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mn>0</mml:mn><mml:mo>,</mml:mo><mml:msup><mml:mi>σ</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:math></inline-formula> is Gaussian noise. This model can capture both seasonal variation in mortality and a yearly trend over recent years due to changing population structure or socio-economic factors.</p><p>As an example, using monthly death data from Russia (<inline-formula><mml:math id="inf15"><mml:mrow><mml:msup><mml:mi>R</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mo>=</mml:mo><mml:mn>0.72</mml:mn></mml:mrow></mml:math></inline-formula>, <inline-formula><mml:math id="inf16"><mml:mrow><mml:mi>F</mml:mi><mml:mo>=</mml:mo><mml:mn>10.2</mml:mn></mml:mrow></mml:math></inline-formula>), we obtained <inline-formula><mml:math id="inf17"><mml:mrow><mml:mover accent="true"><mml:mi>β</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mo>=</mml:mo><mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mn>2346</mml:mn></mml:mrow><mml:mo>±</mml:mo><mml:mn>528</mml:mn></mml:mrow></mml:mrow></mml:math></inline-formula> (± standard error), meaning that each year the number of monthly deaths decreases on average by ∼2300, and so the predicted monthly deaths for 2020 are ∼7000 lower than the 2015–2019 average. In contrast, using weekly data from the United States (<inline-formula><mml:math id="inf18"><mml:mrow><mml:msup><mml:mi>R</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mo>=</mml:mo><mml:mn>0.89</mml:mn></mml:mrow></mml:math></inline-formula>, <inline-formula><mml:math id="inf19"><mml:mrow><mml:mi>F</mml:mi><mml:mo>=</mml:mo><mml:mn>31.7</mml:mn></mml:mrow></mml:math></inline-formula>), we obtained <inline-formula><mml:math id="inf20"><mml:mrow><mml:mover accent="true"><mml:mi>β</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mo>=</mml:mo><mml:mrow><mml:mn>773</mml:mn><mml:mo>±</mml:mo><mml:mn>57</mml:mn></mml:mrow></mml:mrow></mml:math></inline-formula>, meaning that each year the number of weekly deaths increases on average by ∼800. In these two cases, as well as in many others, the yearly trend was strong and statistically significant, and using the average 2015–2019 data as baseline, as is sometimes done, would therefore not be appropriate.</p><p>We took the model prediction for 2020 as the baseline for excess mortality calculations:<disp-formula id="equ3"><label>(2)</label><mml:math id="m3"><mml:mrow><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>α</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub><mml:mo>+</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>β</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mo>⋅</mml:mo><mml:mn>2020</mml:mn></mml:mrow></mml:mrow></mml:mrow><mml:mo>.</mml:mo></mml:mrow></mml:math></disp-formula></p><p>For the countries with weekly data, the model was fit using weeks 1–52, as the week 53 only happens in rare years (including 2020). The baseline for week 53 was then taken as equal to the value obtained for week 52. We took the same baseline for 2021 as for 2020, to avoid further extrapolation.</p><p>The excess mortality in each week (or month, or quarter) was defined as the difference between the actually observed death number and the baseline prediction. Note that the excess mortality can be negative, whenever the observed number of deaths is below the baseline. We summed the excess mortality estimates across all weeks starting from March 2020 (week 10; for monthly data, we started summation from March 2020; for quarterly data, from the beginning of 2020). This yields the final estimate of the excess mortality:<disp-formula id="equ4"><label>(3)</label><mml:math id="m4"><mml:mrow><mml:mrow><mml:mi mathvariant="normal">Δ</mml:mi><mml:mo>=</mml:mo><mml:mrow><mml:mrow><mml:munder><mml:mo largeop="true" movablelimits="false" symmetric="true">∑</mml:mo><mml:mrow><mml:mi>t</mml:mi><mml:mo>≥</mml:mo><mml:msub><mml:mi>t</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:mrow></mml:munder><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mrow><mml:msub><mml:mi>D</mml:mi><mml:mrow><mml:mi>t</mml:mi><mml:mo>,</mml:mo><mml:mn>2020</mml:mn></mml:mrow></mml:msub><mml:mo>-</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mrow><mml:mo>+</mml:mo><mml:mrow><mml:munder><mml:mo largeop="true" movablelimits="false" symmetric="true">∑</mml:mo><mml:mi>t</mml:mi></mml:munder><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mrow><mml:msub><mml:mi>D</mml:mi><mml:mrow><mml:mi>t</mml:mi><mml:mo>,</mml:mo><mml:mn>2021</mml:mn></mml:mrow></mml:msub><mml:mo>-</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:mrow><mml:mo>,</mml:mo></mml:mrow></mml:math></disp-formula>where <italic>t</italic><sub>1</sub> denotes the beginning of summation in 2020.</p><p>We computed the variance <inline-formula><mml:math id="inf21"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mtext>Var</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:mi mathvariant="normal">Δ</mml:mi><mml:mo stretchy="false">]</mml:mo></mml:mrow></mml:mstyle></mml:math></inline-formula> of our estimator Δ as follows. Let <inline-formula><mml:math id="inf22"><mml:mi mathvariant="bold">𝐗</mml:mi></mml:math></inline-formula> be the predictor matrix in the regression, <inline-formula><mml:math id="inf23"><mml:mi mathvariant="bold">𝐲</mml:mi></mml:math></inline-formula> be the response vector, <inline-formula><mml:math id="inf24"><mml:mrow><mml:mover accent="true"><mml:mi mathvariant="bold-italic">𝜷</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mo>=</mml:mo><mml:mrow><mml:msup><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mrow><mml:msup><mml:mi mathvariant="bold">𝐗</mml:mi><mml:mo>⊤</mml:mo></mml:msup><mml:mo>⁢</mml:mo><mml:mi mathvariant="bold">𝐗</mml:mi></mml:mrow><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup><mml:mo>⁢</mml:mo><mml:msup><mml:mi mathvariant="bold">𝐗</mml:mi><mml:mo>⊤</mml:mo></mml:msup><mml:mo>⁢</mml:mo><mml:mi mathvariant="bold">𝐲</mml:mi></mml:mrow></mml:mrow></mml:math></inline-formula> be the vector of estimated regression coefficients, and <inline-formula><mml:math id="inf25"><mml:mrow><mml:msup><mml:mover accent="true"><mml:mi>σ</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mn>2</mml:mn></mml:msup><mml:mo>=</mml:mo><mml:mrow><mml:msup><mml:mrow><mml:mo>∥</mml:mo><mml:mrow><mml:mi mathvariant="bold">𝐲</mml:mi><mml:mo>-</mml:mo><mml:mrow><mml:mi mathvariant="bold">𝐗</mml:mi><mml:mo>⁢</mml:mo><mml:mover accent="true"><mml:mi mathvariant="bold-italic">𝜷</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow></mml:mrow><mml:mo>∥</mml:mo></mml:mrow><mml:mn>2</mml:mn></mml:msup><mml:mo>/</mml:mo><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mrow><mml:mi>n</mml:mi><mml:mo>-</mml:mo><mml:mi>p</mml:mi></mml:mrow><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mrow></mml:mrow></mml:math></inline-formula> be the unbiased estimate of the noise variance, where <inline-formula><mml:math id="inf26"><mml:mi>n</mml:mi></mml:math></inline-formula> is the sample size and <inline-formula><mml:math id="inf27"><mml:mi>p</mml:mi></mml:math></inline-formula> is the number of predictors. Then <inline-formula><mml:math id="inf28"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mtext>Cov</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:mrow><mml:mover><mml:mi mathvariant="bold-italic">β</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mo stretchy="false">]</mml:mo><mml:mo>=</mml:mo><mml:msup><mml:mrow><mml:mover><mml:mi>σ</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo stretchy="false">(</mml:mo><mml:msup><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">⊤</mml:mi></mml:mrow></mml:msup><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:msup><mml:mo stretchy="false">)</mml:mo><mml:mrow><mml:mo>−</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:mstyle></mml:math></inline-formula> is the covariance matrix of <inline-formula><mml:math id="inf29"><mml:mover accent="true"><mml:mi mathvariant="bold-italic">𝜷</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:math></inline-formula> and <inline-formula><mml:math id="inf30"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mrow><mml:mi mathvariant="bold">S</mml:mi></mml:mrow><mml:mo>=</mml:mo><mml:mtext>Cov</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:msub><mml:mrow><mml:mover><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mo stretchy="false">]</mml:mo><mml:mo>=</mml:mo><mml:mtext>Cov</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:msub><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:mrow><mml:mn>2020</mml:mn></mml:mrow></mml:msub><mml:mrow><mml:mover><mml:mi mathvariant="bold-italic">β</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mo stretchy="false">]</mml:mo><mml:mo>=</mml:mo><mml:msup><mml:mrow><mml:mover><mml:mi>σ</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:msub><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:mrow><mml:mn>2020</mml:mn></mml:mrow></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msup><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">⊤</mml:mi></mml:mrow></mml:msup><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:msup><mml:mo stretchy="false">)</mml:mo><mml:mrow><mml:mo>−</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup><mml:msubsup><mml:mrow><mml:mi mathvariant="bold">X</mml:mi></mml:mrow><mml:mrow><mml:mn>2020</mml:mn></mml:mrow><mml:mrow><mml:mi mathvariant="normal">⊤</mml:mi></mml:mrow></mml:msubsup></mml:mrow></mml:mstyle></mml:math></inline-formula> is the covariance matrix of the predicted baseline values <inline-formula><mml:math id="inf31"><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> where <inline-formula><mml:math id="inf32"><mml:msub><mml:mi mathvariant="bold">𝐗</mml:mi><mml:mn>2020</mml:mn></mml:msub></mml:math></inline-formula> is the predictor matrix for the entire 2020. We introduce vector <inline-formula><mml:math id="inf33"><mml:mi mathvariant="bold">𝐰</mml:mi></mml:math></inline-formula> with elements <italic>w</italic><sub><italic>t</italic></sub> of length equal to the number of rows in <inline-formula><mml:math id="inf34"><mml:msub><mml:mi mathvariant="bold">𝐗</mml:mi><mml:mn>2020</mml:mn></mml:msub></mml:math></inline-formula>, set all elements before <italic>t</italic><sub>1</sub> to zero, all elements starting from <italic>t</italic><sub>1</sub> to 1, and increase by one all elements corresponding to the existing 2021 data. Then the ‘predictive’ variance of Δ is given by<disp-formula id="equ5"><label>(4)</label><mml:math id="m5"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mtext>Var</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:mi mathvariant="normal">Δ</mml:mi><mml:mo stretchy="false">]</mml:mo><mml:mo>=</mml:mo><mml:mtext>Var</mml:mtext><mml:mrow><mml:mo maxsize="1.2em" minsize="1.2em">[</mml:mo></mml:mrow><mml:munder><mml:mo>∑</mml:mo><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:munder><mml:msub><mml:mi>w</mml:mi><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:msub><mml:mrow><mml:mover><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:mrow><mml:mo maxsize="1.2em" minsize="1.2em">]</mml:mo></mml:mrow><mml:mo>+</mml:mo><mml:munder><mml:mo>∑</mml:mo><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:munder><mml:msub><mml:mi>w</mml:mi><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub><mml:msup><mml:mrow><mml:mover><mml:mi>σ</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:msup><mml:mrow><mml:mi mathvariant="bold">w</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">⊤</mml:mi></mml:mrow></mml:msup><mml:mrow><mml:mi mathvariant="bold">S</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="bold">w</mml:mi></mml:mrow><mml:mo>+</mml:mo><mml:msup><mml:mrow><mml:mover><mml:mi>σ</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo fence="false" stretchy="false">‖</mml:mo><mml:mrow><mml:mi mathvariant="bold">w</mml:mi></mml:mrow><mml:msub><mml:mo fence="false" stretchy="false">‖</mml:mo><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub><mml:mo>,</mml:mo></mml:mrow></mml:mstyle></mml:math></disp-formula>where the first term corresponds to the uncertainty of <inline-formula><mml:math id="inf35"><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> and the second term corresponds to the additive Gaussian noise that 2020–2021 observations would have had on top of <inline-formula><mml:math id="inf36"><mml:msub><mml:mi>B</mml:mi><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula> without the pandemic event (<xref ref-type="bibr" rid="bib1">Abramovich and Ritov, 2013</xref>). We took the square root of <inline-formula><mml:math id="inf37"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mtext>Var</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:mi mathvariant="normal">Δ</mml:mi><mml:mo stretchy="false">]</mml:mo></mml:mrow></mml:mstyle></mml:math></inline-formula> as the standard error of Δ. Whenever the fraction <inline-formula><mml:math id="inf38"><mml:mstyle displaystyle="true" scriptlevel="0"><mml:mrow><mml:mi>z</mml:mi><mml:mo>=</mml:mo><mml:mrow><mml:mo stretchy="false">|</mml:mo></mml:mrow><mml:mi mathvariant="normal">Δ</mml:mi><mml:mrow><mml:mo stretchy="false">|</mml:mo></mml:mrow><mml:mrow><mml:mo>/</mml:mo></mml:mrow><mml:msqrt><mml:mtext>Var</mml:mtext><mml:mo stretchy="false">[</mml:mo><mml:mi mathvariant="normal">Δ</mml:mi><mml:mo stretchy="false">]</mml:mo></mml:msqrt></mml:mrow></mml:mstyle></mml:math></inline-formula> was below 2, we considered the excess mortality for that country to be not significantly different from zero. Note that we could not estimate the uncertainty for Argentina and South Africa because raw historical data were not available (see above).</p><p>There exist more elaborate statistical approaches for estimating the baseline (and thus the excess) mortality, for example modeling the seasonal variation using periodic splines or Fourier harmonics, or controlling for the time-varying population size and age structure, or using a Poisson model (<xref ref-type="bibr" rid="bib20">Farrington et al., 1996</xref>; <xref ref-type="bibr" rid="bib52">Noufaily et al., 2013</xref>), etc. We believe that our method achieves the compromise between flexibility and simplicity: it is the simplest approach that captures both the seasonal variation and the yearly trend, and is far more transparent than more elaborate methods. Note that our uncertainty estimation assumes iid noise in <xref ref-type="disp-formula" rid="equ2">Equation 1</xref>. In reality, the noise may be temporally or spatially autocorrelated, which would affect the variance of <inline-formula><mml:math id="inf39"><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula>.</p><p>Past (2015–2019) influenza outbreaks contributed to the estimation of the baseline <inline-formula><mml:math id="inf40"><mml:msub><mml:mover accent="true"><mml:mi>B</mml:mi><mml:mo stretchy="false">^</mml:mo></mml:mover><mml:mi>t</mml:mi></mml:msub></mml:math></inline-formula>. As a consequence, our baseline captures the expected mortality without the COVID-19 pandemic, but in the presence of usual seasonal influenza. This differs from the approach taken by EuroMomo as well as by some studies of excess mortality due to influenza pandemics (<xref ref-type="bibr" rid="bib67">Viboud et al., 2005</xref>; <xref ref-type="bibr" rid="bib59">Simonsen et al., 2013</xref>), where the baseline is constructed in a way that weighs down previous influenza outbreaks so that each new outbreak would result in positive excess mortality. A parallel work on COVID-19 excess mortality based on the STMF dataset (<xref ref-type="bibr" rid="bib31">Islam et al., 2021</xref>) also used that approach, which explains some of the differences between our estimates.</p></sec><sec id="s4-4"><title>COVID-unrelated causes of excess mortality</title><p>We subtracted 4000 from the excess mortality estimates for Armenia and Azerbaijan to account for the 2020 Nagorno-Karabakh war. By official counts, it cost ∼3400 lives in Armenia and ∼2800 in Azerbaijan (<xref ref-type="bibr" rid="bib72">Welt and Bowen, 2021</xref>), but we took 4000 deaths in each country to obtain a conservative estimate of COVID-related excess mortality. To the best of our knowledge, no other armed conflict in 2020–2021 resulted in more than 100 casualties in countries included in our dataset.</p><p>Another correction was done for Belgium, Netherlands, France, Luxembourg, and Germany, where our data show a peak of excess deaths in August 2020, not associated with COVID-19 (see below and <xref ref-type="fig" rid="fig4">Figure 4</xref>) and likely corresponding to a heat wave (<xref ref-type="bibr" rid="bib25">Fouillet et al., 2006</xref>; <xref ref-type="bibr" rid="bib26">Fouillet et al., 2008</xref>; <xref ref-type="bibr" rid="bib24">Flynn et al., 2005</xref>). We excluded weeks 32–34 from the excess mortality calculation in these five countries. This decreased the excess mortality estimates for these countries by 1500, 660, 1600, 35, and 3700, respectively.</p><p>The EM-DAT database of natural disasters (<ext-link ext-link-type="uri" xlink:href="https://www.emdat.be">https://www.emdat.be</ext-link>) lists only the following four natural disasters with over 200 fatalities in 2020–2021 in countries included in our dataset: the August heat wave in Belgium, France, and the Netherlands, and a sequence of heat waves in the United Kingdom in June–August 2020 (2500 casualties). We do not see clear peaks in our data associated with these heat waves, possibly because our United Kingdom data are by the date of registration and not by the date of death. We have therefore chosen not to adjust our excess mortality estimate for the United Kingdom.</p><p>Note that other countries may also have experienced non-COVID-related events leading to excess mortality. However, as these events are not included in the EM-DAT database, we assume that their effect would be small in comparison to the effect of COVID-19. For example, Russian data suggest ∼10,000 excess deaths from a heat wave in July 2020 in Ural and East Siberia (<xref ref-type="bibr" rid="bib33">Kobak, 2021a</xref>). We do not correct for it in this work as it is difficult to separate July 2020 excess deaths into those due to COVID and those due to the heat wave, based on the Russian country-level data alone, and we are not aware of any reliable published estimates. Importantly, 10,000 is only a small fraction of the total number of excess deaths in Russia. Another case is the February 2021 power crisis in Texas, USA, that has been estimated by <italic>BuzzFeed News</italic> to have yielded ∼700 excess deaths (<xref ref-type="bibr" rid="bib3">Aldhous et al., 2021</xref>). Again, this number is small compared to the total number of excess deaths in the United States.</p></sec><sec id="s4-5"><title>Official COVID mortality</title><p>We took the officially reported COVID-19 death counts from the World Health Organization (WHO) dataset (<ext-link ext-link-type="uri" xlink:href="https://covid19.who.int">https://covid19.who.int</ext-link>). To find the number of officially reported COVID-19 deaths at the time corresponding to our excess mortality estimate, we assumed that all weekly data conform to the ISO 8601 standard, and took the officially reported number on the last day of the last week available in our dataset. Some countries use non-ISO weeks (e.g. starting from January 1st), but the difference is at most several days. ISO weeks are also assumed in the ‘Data until’ column in <xref ref-type="table" rid="table1">Table 1</xref>. Officially reported numbers for Hong Kong, Macao, and Taiwan, absent in the WHO dataset, were taken from the Johns Hopkins University (JHU) dataset (<ext-link ext-link-type="uri" xlink:href="https://coronavirus.jhu.edu">https://coronavirus.jhu.edu</ext-link>) (<xref ref-type="bibr" rid="bib17">Dong et al., 2020</xref>) as distributed by <italic>Our World in Data</italic>. We manually added officially reported numbers for Transnistria (1,195 by the end of May 2021: taken from the Telegram channel <ext-link ext-link-type="uri" xlink:href="https://t.me/novostipmrcom">https://t.me/novostipmrcom</ext-link>).</p><p>Note that for some countries there exist different sources of official data, e.g. Russia officially reports monthly numbers of confirmed and suspected COVID deaths that are substantially larger than the daily reported numbers (<xref ref-type="bibr" rid="bib33">Kobak, 2021a</xref>). However, it is the daily reported numbers that get into the WHO and JHU dashboards, so for consistency, here we always use the daily values.</p><p>We defined undercount ratio as the number of excess deaths divided by the official number of COVID-19 deaths reported by the same date. If the number of excess deaths is negative, the undercount ratio is not defined. Additionally, we chose not to show undercount ratios for countries with positive number of excess deaths where there is no evidence that excess deaths were due to COVID (Cuba, Hong Kong, Thailand). For these three countries there was no correlation between the monthly excess deaths and reported monthly numbers of COVID-19 deaths or cases, and no media reports of COVID outbreaks.</p></sec><sec id="s4-6"><title>Population size estimates</title><p>To estimate excess deaths per 100,000 population, we obtained population size estimates for 2020 from the United Nations World Population Prospect (WPP) dataset (<ext-link ext-link-type="uri" xlink:href="https://population.un.org/wpp/">https://population.un.org/wpp/</ext-link>). The value for Russia in that dataset does not include Crimea due to its disputed status, but all Russian data of all-cause and COVID-19 mortality does include Crimea. For that reason, we used the population value of 146,748,590, provided by the Russian Federal State Statistics Service, and similarly changed the value for Ukraine to 41,762,138, provided by the Ukranian State Statistics Service. The number for Transnistria was absent in the World Population Prospect dataset, so we used the value obtained from its NSO (465,200). Additionally, WPP reports population data for Serbia and Kosovo combined. We thus obtained population values for these countries from the World Bank Dataset (<ext-link ext-link-type="uri" xlink:href="https://data.worldbank.org/indicator/SP.POP.TOTL">https://data.worldbank.org/indicator/SP.POP.TOTL</ext-link>).</p><p>Note that some of the population size estimates in the World Population Prospect dataset may be outdated or unreliable. Therefore, for some of the countries our excess death rates may be only approximate (<xref ref-type="bibr" rid="bib60">Spoorenberg, 2020</xref>).</p></sec><sec id="s4-7"><title>Data and code availability</title><p>The World Mortality Dataset is available at <ext-link ext-link-type="uri" xlink:href="https://github.com/akarlinsky/world_mortality">https://github.com/akarlinsky/world_mortality</ext-link>, (copy archived at <ext-link ext-link-type="uri" xlink:href="https://archive.softwareheritage.org/swh:1:dir:2079acfc53a077c0387a8e7d5691484ed4ff1524;origin=https://github.com/akarlinsky/world_mortality;visit=swh:1:snp:e16eceb5d3c6e5f0774705a19fcc5c2e11164a21;anchor=swh:1:rev:03534f5db091e7dbada157e4eb92d663b1d1287f">swh:1:rev:03534f5db091e7dbada157e4eb92d663b1d1287f</ext-link>, <xref ref-type="bibr" rid="bib32">Karlinsky and Kobak, 2021</xref>). The analysis code is available at <ext-link ext-link-type="uri" xlink:href="https://github.com/dkobak/excess-mortality">https://github.com/dkobak/excess-mortality</ext-link> (copy archived at <ext-link ext-link-type="uri" xlink:href="https://archive.softwareheritage.org/swh:1:dir:157bb3df01c87ad8b40a39969043db3f5cc6b63b;origin=https://github.com/dkobak/excess-mortality;visit=swh:1:snp:ca07bda367830a00a22ef4ed100bc923b0ecabad;anchor=swh:1:rev:f765cf8bb7d3246bed22f85c832a63b0cf58b904">swh:1:rev:f765cf8bb7d3246bed22f85c832a63b0cf58b904</ext-link>, <xref ref-type="bibr" rid="bib34">Kobak, 2021b</xref>). Our baseline estimates for all countries and all values shown in <xref ref-type="table" rid="table1">Table 1</xref> are available there as CSV files. Frozen data, data sources and code for the paper are available at <ext-link ext-link-type="uri" xlink:href="https://github.com/dkobak/excess-mortality/tree/main/elife2021">https://github.com/dkobak/excess-mortality/tree/main/elife2021</ext-link> (data update from July 3, 2021).</p></sec></sec></body><back><ack id="ack"><title>Acknowledgements</title><p>The authors would like to thank colleagues at Kohelet Policy Forum and Mida'at, Frédéric Fleury-Payeur, Michael Beenstock, Maxim S Pshenichnikov, Tim Riffe, and eLife reviewers Marc Lipsitch, Ayesha Mahmud, and Lone Simonsen for their helpful comments and G J Andrés Uzín P, Luis Salas, Marcelo Oliveira, Otavio Ranzani, Mario Romero Zavala, Laurianne Despeghel, reporters from Eurasianet, Dmitri Tokarev, Michael Hilliard, Andrés N Robalino, LAB-DAT, Noah Katz, Mikhail Zelenskiy, and Gilad Gaibel for their help in obtaining some of the data. DK was supported by the Deutsche Forschungsgemeinschaft (BE5601/4-1 and the Cluster of Excellence ‘‘Machine Learning — New Perspectives for Science’’, EXC 2064, project number 390727645), the Federal Ministry of Education and Research (FKZ 01GQ1601 and 01IS18039A) and the National Institute of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.</p></ack><sec id="s5" sec-type="additional-information"><title>Additional information</title><fn-group content-type="competing-interest"><title>Competing interests</title><fn fn-type="COI-statement" id="conf1"><p>No competing interests declared</p></fn></fn-group><fn-group content-type="author-contribution"><title>Author contributions</title><fn fn-type="con" id="con1"><p>Resources, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing - original draft, Writing - review and editing</p></fn><fn fn-type="con" id="con2"><p>Formal analysis, Visualization, Methodology, Writing - original draft, Writing - review and editing</p></fn></fn-group></sec><sec id="s6" sec-type="supplementary-material"><title>Additional files</title><supplementary-material id="transrepform"><label>Transparent reporting form</label><media mime-subtype="pdf" mimetype="application" xlink:href="elife-69336-transrepform-v3.pdf"/></supplementary-material></sec><sec id="s7" sec-type="data-availability"><title>Data availability</title><p>Full data are publicly available at: <ext-link ext-link-type="uri" xlink:href="https://github.com/akarlinsky/world_mortality">https://github.com/akarlinsky/world_mortality</ext-link> (copy archived at <ext-link ext-link-type="uri" xlink:href="https://archive.softwareheritage.org/swh:1:rev:03534f5db091e7dbada157e4eb92d663b1d1287f">https://archive.softwareheritage.org/swh:1:rev:03534f5db091e7dbada157e4eb92d663b1d1287f</ext-link>).</p><p>The following dataset was generated:</p><p><element-citation id="dataset1" publication-type="data" specific-use="isSupplementedBy"><person-group person-group-type="author"><name><surname>Karlinsky</surname><given-names>A</given-names></name><name><surname>Kobak</surname><given-names>D</given-names></name></person-group><year 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id="sa1"><front-stub><article-id pub-id-type="doi">10.7554/eLife.69336.sa1</article-id><title-group><article-title>Decision letter</article-title></title-group><contrib-group><contrib contrib-type="editor"><name><surname>Lipsitch</surname><given-names>Marc</given-names></name><role>Reviewing Editor</role><aff><institution>Harvard TH Chan School of Public Health</institution><country>United States</country></aff></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name><surname>Lipsitch</surname><given-names>Marc</given-names> </name><role>Reviewer</role><aff><institution>Harvard TH Chan School of Public Health</institution><country>United States</country></aff></contrib><contrib contrib-type="reviewer"><name><surname>Simonsen</surname><given-names>Lone</given-names> </name><role>Reviewer</role></contrib><contrib contrib-type="reviewer"><name><surname>Mahmud</surname><given-names>Ayesha</given-names> </name><role>Reviewer</role><aff><institution>University of California, Berkeley</institution><country>United States</country></aff></contrib></contrib-group></front-stub><body><boxed-text><p>Our editorial process produces two outputs: (i) <ext-link ext-link-type="uri" xlink:href="https://sciety.org/articles/activity/10.1101/2021.01.27.21250604">public reviews</ext-link> designed to be posted alongside <ext-link ext-link-type="uri" xlink:href="https://www.medrxiv.org/content/10.1101/2021.01.27.21250604v2">the preprint</ext-link> for the benefit of readers; (ii) feedback on the manuscript for the authors, including requests for revisions, shown below. We also include an acceptance summary that explains what the editors found interesting or important about the work.</p></boxed-text><p><bold>Acceptance summary:</bold></p><p>This is a comprehensive effort to compile excess mortality data during the ongoing COVID-19 pandemic, resulting in a regularly updated, publicly available data set from which other investigators can depart to answer their own questions, and in which these investigators show the range of &quot;excess&quot; mortality, ranging from negative excess in countries with little COVID-19 to as much as 50% excess over normal rates in hard-hit countries. This also permits estimation of underreporting of deaths and its variation in space and time. This will be a highly valuable resource for many.</p><p><bold>Decision letter after peer review:</bold></p><p>Thank you for submitting your article &quot;The World Mortality Dataset: Tracking excess mortality across countries during the COVID-19 pandemic&quot; for consideration by <italic>eLife</italic>. Your article has been reviewed by 3 peer reviewers, including Marc Lipsitch as the Reviewing Editor and Reviewer #1, and the evaluation has been overseen by a Senior Editor, Miles Davenport. The following individuals involved in review of your submission have agreed to reveal their identity: Simonsen (Reviewer #2); Ayesha Mahmud (Reviewer #3).</p><p>The reviewers have discussed their reviews with one another, and the Reviewing Editor has drafted this to help you prepare a revised submission.</p><p>Essential Revisions:</p><p>1. Work is not connected to the vast literature on the topic. The authors are out-of-field statisticians and seem unaware of the literature in this domain. They had generate a baseline of expected mortality based on past years time series data, as one would do when estimating excess mortality for influenza. In this way their approach is a bit similar to that used by Murray et al., (Murray, Lancet 2006) to estimate the 1918 pandemic excess mortality above an annual baseline of surrounding years for a number of countries. The authors should consider at least including a reference for excess mortality estimation for each of the past influenza virus pandemics, and ponder whether it is possible to do the same that was done in these analyses to create a baseline of expected deaths that did NOT include winter-seasonal epidemic diseases like influenza (see the collected works of Olson et al., Viboud et al., Chowell et al., Olson et al., Simonsen et al., for the pandemics of 1918, 1957, 1968 and 2009). See also the latest thinking on the problem of sorting out true excess deaths from the disappeared traffic accidents, increased mental health deaths, and other complications by IHME.</p><p>2. No attempt to correct baselines for seasonal influenza. The authors use past years and generate a baseline that includes mid-winter seasonal influenza mortality. By doing so, the excess mortality estimates in the present manuscript represent excess above what is normal in a season. Thus, as the authors comment on, the excess mortality estimates are affected by the too high baseline which includes mortality due to influenza, RSV and other respiratory viruses that are now largely not circulating during the COVID-19 pandemic. Particularly, the &quot;disappeared&quot; influenza burden in 2020-2021 results in a meaningful underestimation of the true COVID-19 excess mortality. This problem of removing seasonal influenza from the baseline has actually been worked out by epidemiologists using various statistical approaches (sometimes harmonic terms, sometimes using influenza virus data from the WHO as predictors) in the field of epidemiology the literature mentioned above, but the entire literature of excess mortality estimation is missing from the reference list. One that I am very familiar with is Simonsen et al., Plos Med 2014 – but there are many many more similar published papers computing excess mortality for seasonal and recent pandemic influenza out there (look for Viboud, Chowell, Goldstein, Paget, Olson…..). I suggest you simply discuss this situation, and make reference to this – plus suggest others to work out ways to remove influenza from the baseline, for example incorporate WHOs seasonal influenza timeseries database data (FluNet.org) in the excess mortality regression models (to identify and remove excess mortality during influenza periods).</p><p>3. Varying COVID-19 study time for different countries. Another problem with the way they report the excess mortality is in the difference in follow-up time. Some countries have data up to March 2021, while others only until last summer. This should be dealt with in the estimates, for example by comparing countries with complete year 2000 data. It probably cannot be helped that some countries publish their data late, but the authors should highlight these issues of comparison between countries in the text.</p><p>4. About the finding of a 1.6x higher excess mortality than reported deaths. It seems important to say that this is a finding for countries with national vital statistics in near-real time, so things may be very different in countries where such data to not exist.</p><p>5. Figure 4. Can you explain the time shift between the reported and excess deaths in the United States? Must be a data issue. Also, would be better to choose line colors or width so that one can distinguish the two in black and white.</p><p>6. Please expand on the interpretation of excess deaths. From a causal perspective, the notion of excess deaths is:</p><p>Observed deaths in COVID period =</p><p>Expected deaths in COVID period (a) –</p><p>Deaths averted due to COVID (eg less flu due to NPIs, less traffic death, ) (b)+</p><p>Deaths directly caused by COVID (ie in people who were infected) (c)+</p><p>Deaths indirectly caused by COVID (starvation from lockdown, untreated cancer) (d)+</p><p>Net death from confounders (other events that were particular to that time period and caused or prevented deaths -- eg wars) (e)</p><p>+ Random variation.</p><p>The main thing I would like to see is more contextualization of the &quot;undercount&quot; to note something like this conceptual structure, explain what should make us think that the very few examples of (e) that are in the analysis really are the main ones, and perhaps some seasonal comparisons of the undercounts so that plausible hypotheses can be proposed for which factors are at play.</p><p>7) Is it possible to do the age-standardization for countries in the top 10 in Figure 3. For example, the countries in the bottom left panel to see if the ordering changes?</p><p>8) The timing of outbreaks in different countries will affect the estimate of excess mortality. You note, &quot;We summed the excess mortality estimates across all weeks starting from the week t1 when the country reported its first COVID-19 death&quot;. First, how do we account for changes in reporting as an outbreak progresses in a country? Second, for countries that have a later introduction of the outbreak, and/or see a later peak relative to other countries (for example, India), then they will automatically have a smaller estimate of excess death because of right censoring of the data. How is this accounted for?</p><p>9) It would be good to add some discussion on how your excess mortality estimates compare to the many estimates available in the literature.</p><p>10) Figure 2 needs x axis labels.</p><p>11) A lot of the results are presented in a comparative framework but it's very difficult to compare excess mortality rates across different populations. Perhaps reframing some of this as a way to assess a country's own burden compared to its baseline rather than comparing across countries might be helpful.</p><p>12) Some discussion on why Peru seems to be such an outlier would be helpful (i.e. Figure 3).</p><p>13) Section 2.2 describes some adjustments (for e.g. for Ireland and Sweden). Some sensitivity analyses would be helpful. For example. the redistribution of deaths for Sweden ignores seasonality. What is the consequence of that assumption?</p><p><italic>Reviewer #1 (Recommendations for the authors):</italic></p><p>I found the use of t statistics confusing as t has another meaning (time) and while this may be standard in some fields it is not in epidemiology (presenting the t statistic rather than the p value)</p><p><italic>Reviewer #2 (Recommendations for the authors):</italic></p><p>Well done, nice paper. Alarming conclusion. Great resource for the field. A few things to fix.</p><p><italic>Reviewer #3 (Recommendations for the authors):</italic></p><p>Thanks to the authors for this nice paper, and for collecting and making all the data publicly available. Some comments and suggestions (in no particular order) are below:</p><p>1) Is it possible to do the age-standardization for countries in the top 10 in Figure 3. For example, the countries in the bottom left panel to see if the ordering changes?</p><p>2) The timing of outbreaks in different countries will affect the estimate of excess mortality. You note, &quot;We summed the excess mortality estimates across all weeks starting from the week t1 when the country reported its first COVID-19 death&quot;. First, how do we account for changes in reporting as an outbreak progresses in a country? Second, for countries that have a later introduction of the outbreak, and/or see a later peak relative to other countries (for example, India), then they will automatically have a smaller estimate of excess death because of right censoring of the data. How is this accounted for?</p><p>3) It would be good to add some discussion on how your excess mortality estimates compare to the many estimates available in the literature.</p><p>4) Figure 2 needs x axis labels.</p><p>5) I think a lot of the results are presented in a comparative framework but it's very difficult to compare excess mortality rates across different populations. Perhaps reframing some of this as a way to assess a country's own burden compared to its baseline rather than comparing across countries might be helpful.</p><p>6) Some discussion on why Peru seems to be such an outlier would be helpful (i.e. Figure 3).</p><p>7) Section 2.2 describes some adjustments (for e.g. for Ireland and Sweden). Some sensitivity analyses would be helpful. For eg. the redistribution of deaths for Sweden ignores seasonality. What is the consequence of that assumption?</p></body></sub-article><sub-article article-type="reply" id="sa2"><front-stub><article-id pub-id-type="doi">10.7554/eLife.69336.sa2</article-id><title-group><article-title>Author response</article-title></title-group></front-stub><body><p>Essential Revisions:</p><disp-quote content-type="editor-comment"><p>1. Work is not connected to the vast literature on the topic. The authors are out-of-field statisticians and seem unaware of the literature in this domain. They had generate a baseline of expected mortality based on past years time series data, as one would do when estimating excess mortality for influenza. In this way their approach is a bit similar to that used by Murray et al., (Murray, Lancet 2006) to estimate the 1918 pandemic excess mortality above an annual baseline of surrounding years for a number of countries. The authors should consider at least including a reference for excess mortality estimation for each of the past influenza virus pandemics, and ponder whether it is possible to do the same that was done in these analyses to create a baseline of expected deaths that did NOT include winter-seasonal epidemic diseases like influenza (see the collected works of Olson et al., Viboud et al., Chowell et al., Olson et al., Simonsen et al., for the pandemics of 1918, 1957, 1968 and 2009). See also the latest thinking on the problem of sorting out true excess deaths from the disappeared traffic accidents, increased mental health deaths, and other complications by IHME.</p></disp-quote><p>We thank the reviewer for this comment. We are indeed not very well familiar with the epidemiological literature, and apologize for missing many relevant citations. We have now included into the Introduction citations to Murray et al. 2006, Viboud et al. 2005, Viboud et al. 2016, Simonsen et al. 2013 referring to the 1918, 1957, 1968, 2009 influenza pandemics respectively (as well as some other citations). We would be very happy to include further citations, if suggested by the reviewer.</p><p>Regarding including winter epidemic patterns into the baseline, see our response to the next issue. Regarding IHME’s excess death estimates, we do not consider them credible as their data and methods are opaque and in contrast to existing excess death estimates, and it seems that they have very little actual all-cause-mortality data to work with. We have expanded on this here when the estimates were first released: https://akarlinsky.github.io/_pages/IHME-critique.html. Also, it seems that even</p><p>though IHME mention some disentangling of excess deaths due to COVID from other causes, they do not actually adjust for this, as they state: &quot;Given that there is insufficient evidence to estimate these contributions to excess mortality, for now we assume that total COVID-19 deaths equal excess mortality&quot;.</p><disp-quote content-type="editor-comment"><p>2. No attempt to correct baselines for seasonal influenza. The authors use past years and generate a baseline that includes mid-winter seasonal influenza mortality. By doing so, the excess mortality estimates in the present manuscript represent excess above what is normal in a season. Thus, as the authors comment on, the excess mortality estimates are affected by the too high baseline which includes mortality due to influenza, RSV and other respiratory viruses that are now largely not circulating during the COVID-19 pandemic. Particularly, the &quot;disappeared&quot; influenza burden in 2020-2021 results in a meaningful underestimation of the true COVID-19 excess mortality. This problem of removing seasonal influenza from the baseline has actually been worked out by epidemiologists using various statistical approaches (sometimes harmonic terms, sometimes using influenza virus data from the WHO as predictors) in the field of epidemiology the literature mentioned above, but the entire literature of excess mortality estimation is missing from the reference list. One that I am very familiar with is Simonsen et al., Plos Med 2014 – but there are many many more similar published papers computing excess mortality for seasonal and recent pandemic influenza out there (look for Viboud, Chowell, Goldstein, Paget, Olson…..). I suggest you simply discuss this situation, and make reference to this – plus suggest others to work out ways to remove influenza from the baseline, for example incorporate WHOs seasonal influenza timeseries database data (FluNet.org) in the excess mortality regression models (to identify and remove excess mortality during influenza periods).</p></disp-quote><p>This is an excellent point. We feel that we would not be able to adjust our model to predict influenza-free baseline, because for many countries we have only monthly data, and the data are often available only by the date of registration, which makes it difficult to use Fourier components (see e.g. United Kingdom in Figure 2). Apart from that, we think that our definition of ‘excess’ is sensible for our purposes, as it would yield 0 excess in a hypothetical situation of COVID simply replacing seasonal influenza. In other</p><p>words, our excess is excess above the average seasonal influenza. We have clarified this in the Methods (Section 2.3) as follows: Past (2015–2019) influenza outbreaks contributed to the estimation of the baseline <inline-formula><mml:math id="inf41"><mml:mover><mml:msub><mml:mi>B</mml:mi><mml:mi>t</mml:mi></mml:msub><mml:mo accent="true">̂</mml:mo></mml:mover></mml:math></inline-formula> . As a consequence, our baseline captures the expected mortality without the COVID-19 pandemic, but in the presence of usual seasonal influenza. This differs from the approach taken by EuroMomo as well as by some studies of excess mortality due to influenza pandemics (Viboud et al., 2005, 2016; Simonsen et al., 2013), where the baseline is constructed in a way that weighs down previous influenza outbreaks so that each new outbreak would result in positive excess mortality. A parallel work on COVID-19 excess mortality based on the STMF dataset (Islam et al., 2021) also used that approach, which explains some of the differences between our estimates.</p><disp-quote content-type="editor-comment"><p>3. Varying COVID-19 study time for different countries. Another problem with the way they report the excess mortality is in the difference in follow-up time. Some countries have data up to March 2021, while others only until last summer. This should be dealt with in the estimates, for example by comparing countries with complete year 2000 data. It probably cannot be helped that some countries publish their data late, but the authors should highlight these issues of comparison between countries in the text.</p></disp-quote><p>We absolutely agree that this should be prominently highlighted, so we now included the ‘end dates’ directly into the Figure 3 (we hope that in Figure 2 this is not needed because one can see the entire time series there).</p><p>In addition, we created a supplementary version of this figure that only shows 2020 data (and only for countries that have complete 2020 data).</p><disp-quote content-type="editor-comment"><p>4. About the finding of a 1.6x higher excess mortality than reported deaths. It seems important to say that this is a finding for countries with national vital statistics in near-real time, so things may be very different in countries where such data to not exist.</p></disp-quote><p>This is a great point. To prevent possible misinterpretations, we have now removed all mentions of this ‘global’ undercount ratio until the end of Discussion, where we put it into perspective as follows:</p><p>“Summing up the excess mortality estimates across all countries in our dataset gives 3.7 million excess deaths. In contrast, summing up the official COVID-19 death counts gives 2.5 million deaths, corresponding to the global undercount ratio of 1.5. However, there is ample evidence that among the countries for which the all-cause mortality data are not available the undercount ratio is much higher (Watson et al., 2020; Djaafara et al., 2020; Watson et al., 2021; Mwananyanda et al., 2021; Besson et al., 2021). Using</p><p>a statistical model to predict the excess mortality in the rest of the world based on the existing data from our dataset, The Economist estimated 7–13 million excess deaths worldwide (The Economist, 2021), which is 2–4 times higher than the world’s official COVID-19 death count (currently at 3.5 million).”</p><disp-quote content-type="editor-comment"><p>5. Figure 4. Can you explain the time shift between the reported and excess deaths in the United States? Must be a data issue. Also, would be better to choose line colors or width so that one can distinguish the two in black and white.</p></disp-quote><p>The time shift for the United States in Figure 4 appears to be because the official COVID deaths for the US in the WHO dataset are by the date of reporting and not by the date of death. For all countries we are taking the official COVID deaths from the WHO dataset, but different countries have different approaches to what exactly they report to the WHO.</p><p>We made sure that the figure is readable when printed in grayscale (red is printed as gray). Note that we adjusted the design of this figure and included 4 further countries, so that there 16 countries shown in total.</p><disp-quote content-type="editor-comment"><p>6. Please expand on the interpretation of excess deaths. From a causal perspective, the notion of excess deaths is:</p><p>Observed deaths in COVID period =</p><p>Expected deaths in COVID period (a) –</p><p>Deaths averted due to COVID (eg less flu due to NPIs, less traffic death, ) (b)+</p><p>Deaths directly caused by COVID (ie in people who were infected) (c)+</p><p>Deaths indirectly caused by COVID (starvation from lockdown, untreated cancer) (d)+</p><p>Net death from confounders (other events that were particular to that time period and caused or prevented deaths -- eg wars) (e)</p><p>+ Random variation.</p><p>The main thing I would like to see is more contextualization of the &quot;undercount&quot; to note something like this conceptual structure, explain what should make us think that the very few examples of (e) that are in the analysis really are the main ones, and perhaps some seasonal comparisons of the undercounts so that plausible hypotheses can be proposed for which factors are at play.</p></disp-quote><p>We thank the reviewer for this great suggestion. We have heavily rewritten this part of the Discussion, please see the entire section 4.2, which starts as follows but is too long to copy here entirely:</p><p>Conceptually, excess mortality during the COVID-19 pandemic can be represented as the sum of several distinct factors:</p><p>Excess mortality = (A) Deaths directly caused by COVID infection + (B) Deaths caused by medical system collapse due to COVID pandemic + (C) Excess deaths from other natural causes + (D) Excess deaths from unnatural causes + (E) Excess deaths from extreme events: wars, natural disasters, etc. We explicitly account for factor (E) and argue that for most countries, the contribution of factors (B)–(D) is small in comparison to factor (A), in agreement with the view that excess mortality during an epidemic outbreak can be taken as a proxy for COVID-19 mortality (Beaney et al., 2020). Below we discuss each of the listed factors.</p><disp-quote content-type="editor-comment"><p>7) Is it possible to do the age-standardization for countries in the top 10 in Figure 3. For example, the countries in the bottom left panel to see if the ordering changes?</p></disp-quote><p>Unfortunately, for most countries in the dataset the information about the number of deaths in different age brackets is not available. So we cannot perform the age-standardization. For the countries included in the STMF dataset, this is possible, but this analysis has been done by the STMF team in the parallel paper that was published while we were working on the revision: Islam et al., Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries; BMJ 2021. We refer our readers to that paper.</p><disp-quote content-type="editor-comment"><p>8) The timing of outbreaks in different countries will affect the estimate of excess mortality. You note, &quot;We summed the excess mortality estimates across all weeks starting from the week t1 when the country reported its first COVID-19 death&quot;. First, how do we account for changes in reporting as an outbreak progresses in a country? Second, for countries that have a later introduction of the outbreak, and/or see a later peak relative to other countries (for example, India), then they will automatically have a smaller estimate of excess death because of right censoring of the data. How is this accounted for?</p></disp-quote><p>To ameliorate this issue, we have now fixed t1 = 10 for all countries, i.e. we start the summation of total excess mortality from March 2020 (10th week for weekly data or 3rd month for monthly data). We have also provided ‘end dates’ directly in the Figure 3 and made a supplementary version of Figure 3 that only uses the complete 2020 data.</p><disp-quote content-type="editor-comment"><p>9) It would be good to add some discussion on how your excess mortality estimates compare to the many estimates available in the literature.</p></disp-quote><p>There is a huge number of different estimates in the literature by now. Big efforts that we know about include Kontis et al., Nat Medicine 2020 and Islam et al., BMJ 2021, both based on the STMF dataset. Among media efforts, there are estimates by The Economist and by the Financial Times, both currently based on our dataset. There are also dozens of papers focusing on individual countries. While the analysis is similar everywhere, there are many possible modeling choices: the start date and the end date of the total excess computation, including or excluding influenza into the baseline, including or</p><p>not including trend over years, etc. This makes the estimates slightly different in each case, and the comparison becomes confusing. We would therefore prefer not to provide a detailed comparison. We included the following paragraph into the Discussion:</p><p>“Many countries in our dataset have excess death estimates available in the constantly evolving literature on excess deaths during the COVID-19 pandemic from academia, official institutions and professional associations. The largest efforts include the analysis of STMF data (Kontis et al., 2020; Islam et al., 2021) and excess mortality trackers by The Economist and Financial Times. While the analysis is similar</p><p>everywhere and the estimates broadly agree, there are many possible modeling choices (the start date and the end date of the total excess computation; including or excluding influenza into the baseline; modelling trend over years or not, etc.) making all the estimates slightly different.”</p><disp-quote content-type="editor-comment"><p>10) Figure 2 needs x axis labels.</p></disp-quote><p>Added (to the first subplot).</p><disp-quote content-type="editor-comment"><p>11) A lot of the results are presented in a comparative framework but it's very difficult to compare excess mortality rates across different populations. Perhaps reframing some of this as a way to assess a country's own burden compared to its baseline rather than comparing across countries might be helpful.</p></disp-quote><p>We tried to stay away from focusing too much on the between-country comparisons, but it is difficult to do given the nature of our paper (presenting data for multiple countries). We would be grateful for further suggestions as to how we can adapt the framing.</p><disp-quote content-type="editor-comment"><p>12) Some discussion on why Peru seems to be such an outlier would be helpful (i.e. Figure 3).</p></disp-quote><p>We have inserted the following sentence into the Results:</p><p>“That the highest relative mortality increase was observed in Peru, is in agreement with some parts of Peru showing the highest measured seroprevalence level in the world (Álvarez-Antonio et al., 2021). That paper finds 70% seroprevalence in July 2020 in Iquitos, Peru. Note that the entire second wave happened after July 2020. It is plausible that the number of COVID infections in Peru as a fraction of population is by now above 100% (as people may get infected twice).”</p><disp-quote content-type="editor-comment"><p>13) Section 2.2 describes some adjustments (for e.g. for Ireland and Sweden). Some sensitivity analyses would be helpful. For example the redistribution of deaths for Sweden ignores seasonality. What is the consequence of that assumption?</p></disp-quote><p>We removed the adjustment for Ireland because we changed the data source. For Sweden, the adjustment plays a relatively minor role, as the number of deaths with unknown date is relatively small, as we now say in the text:</p><p>“Sweden has a substantial number of deaths (2.9% of all deaths in 2019; 2.7% in 2020) reported with an ‘unknown’ week.”</p></body></sub-article></article>