>MouseGABAb2 -QSVNDPSN--MSLVKETVDRLL---KGYDIRLRP-DFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQ -------------------------AWRDKRLSYNVIPL-NLTLDNRVADQLWVPDTYFLNDKKSFVHGVTV KNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGD---DNA------ -VTG-VTKIELPQFSIVDYKLITKKVVF-----STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVS FWINYDASAARVALGITTVLTMTTINTHLRETLPKIPY-VKAIDMYLMGCFVFVFMALLEYALVNYIFFGRG PQ--------RQKKAAEKAANA----NNE-KMR-----------------------LDVNKMFYKDIKQNGT QY-RSL----------WDPTGD----------LSPTRRTTNYDFSL-----------YTMDPHENILLSTLE IKNEMATSEAV----------MGLGDPRS--TML--AYDASSIQYRKAGLPRHSFGRNA------------- ---------------------LERH------------VAQKKSRLRRRASQLKITI---------------- -------------------------PDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN------------- ----------------- >MouseGABAb3 -QSVNDPGN--MSFVKETVDKLL---KGYDIRLRP-DFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQ -------------------------YWRDKRLAYSGIPL-NLTLDNRVADQLWVPDTYFLNDKKSFVHGVTV KNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGG---DKA------ -VTG-VERIELPQFSIVEHRLVSRNVVF-----ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVS FWINYDASAARVALGITTVLTMTTINTHLRETLPKIPY-VKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG PQ--------RQKKLAEKTAKA----KND-RSK-----------------------SESNR----------- -----------------------------------------------------------VDAHGNILLTSLE VHNEM--NEVS----------GGIGDTRN--SAI--SFDNSGIQYRKQSMPREGHGRFL------------- ---------------------GDRS------------LPHKKTHLRRRSSQLKIKI---------------- -------------------------PDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN------------- ----------------- >MouseGABAa4 --QNQKEEKLCTENFTRILDSLL---DGYDNRLRP-GFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQ -------------------------TWIDKRLKYDGPIE-ILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTA PNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGP--EKS------ -VEVPKESSSLVQYDLIGQTVSSETIKS-----ITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVS FWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSY-ATAMDWFIAVCFAFVFSALIEFAAVNYFTN-IQ ME--------KAKRKTSKPPQEVPAAPVQ-REK----------------------HPEAP------------ --------------------------------LQNTNANLNMRKRT-----------NALVHSESDVGNRTE VGNHSSKSSTV-------VQESSKGTPRS-------------------YLASSPNPFSR------------- -------------ANAAETISAARA------------LPSASPTS-IRTGYMPRKASVGSASTRHVFGSRLQ RIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLS---KDTMEKSES- ----------------- >GABARho1 LRRSPDITK--SPLTKS--EQLL-RIDDHDFSMRP-GFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRH -------------------------YWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTT DNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKG---NDS------ -LKT-DERISLSQFLIQEFHTTTKLAFYS----STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVS FWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSY-IKAVDIYLWVSFVFVFLSVLEYAAVNYLTT-VQ ER--------KEQKLREKLPCT-------------------------------------------------- ------------------------------------------------------------------------ ---------------------SGLPPPRT--AMLDGNYSDGEVNDLDNYMPENGEKPDR------------- -------------MMVQLTLASERS------------SPQRKS---QRSSYVSMRI---------------- -----------------------------DTHAIDKYSRIIFPAAYILFNLIYWSIFS-------------- ----------------- >GlyRa1 --ARSAPKP--MS-PSDFLDKLMGRTSGYDARIRP-NFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQ -------------------------QWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITT DNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE----QGA------ -VQV-ADGLTLPQFILKEEKDLRYCTKHY----NTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWIS FWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSY-VKAIDIWMAVCLLFVFSALLEYAAVNFVSR-QH KE----LLRFRRKRRHHKSPML-----------------------------------------------NLF QE---------------DEAGEG-----------------RFNFSA-------------------------- ---------------------YGMGPACL--QAKDGISVKGANNSNTTNPPPAPSKSPE------------- -------------EMRKLFIQR-------------------------------------------------- ------------------------------AKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ---- ----------------- >nAChRa7 -----------GEFQRKLYKELV---KNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQM -------------------------SWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFH TNVL--VNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE------------- -ADI-SGYIPNGEWDLVGIPGKRSERFYECC--KEP-YPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLV FLLPADS-GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHH-HD PDG-GKMPKWTRVILLNWCAWFLR---MK-RPG-----------------------EDKV-------RPACQ HK----------------------------------------------------------------QRRCS- ----LASVEMS----------AVAPPPASNGNLL--YIGFRGLDGV-HCVPTPDSG---------------- ------------VVCGRMACSPTHDEHLLHGGQPPEGDPDLAKIL-EEVRYIANRFR--CQDESEAVCSEWK FA----------------------------ACVVD---RLCLMAFSVFTIICTIGILMSAPN---FVEAVSK DFA-------------- >nAChRb3 --------I--AENEDALLRHLF---QGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQ -------------------------EWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLM TKVI--VKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE---N-------- -VDR-KDFFDNGEWEILNAKGMKGNRRDGVY--S---YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLV FYLPSDE-GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHH-RS SSTYHPMAPWVKRLFLQKLPKLLC---MK--------------DHVDRYSS-----PEKEE------SQPVV KG-----------------------------------KVLEKKK---------------------------- -QKQLSDGEKV------------------------------------------------------------- ---------------------------L---------VAFLEKAA-DSIRYISRHVK--KEHFISQVVQDWK FV----------------------------AQVLD---RIFLWLFLIVSVTGSVLIFTPAL----K------ -------MWLHS---YH >nAChRa4 ----HVETR--AHAEERLLKKLF---SGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQ -------------------------EWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHL TKAH--LFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHS---R-------- -VDQ-LDFWESGEWVIVDAVGTYNTRKYECC--AEI-YPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLV FYLPSEC-GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH-RS PRT-HTMPTWVRRVFLDIVPRLLL---MK-RPSVVKDNCRRLIESMHKMASAPRFWPEPEG------EPPAT SGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLS VQHMSSPGEAVEGGVRCRSRSIQYCVPRD--DAA--PEADGQAAG---ALASRNTHSAELPPPDQPSPCKCT CKKEPSSVSPSATVKTRSTKAPPPHLPL---------SPALTRAV-EGVQYIADHLK--AEDTDFSVKEDWK YV----------------------------AMVID---RIFLWMFIIVCLLGTVGLFLP------------- -------PWLAG---MI >nAChRbeta1 -----------SEAEGRLREKLF---SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDL -------------------------EWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALD ISVV--VSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLG---PDGQGHQEI HIHE-GTFIENGQWENIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFV FYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHH-RS PHT-HQMPLWVRQIFIHKLPLYLR---LK-RPK-----------------------PERDL------MPEPP ------------------------------------------------------------------HCSSPG SGWGRGTDEYF------------IRKPPS--DFL--FPKPNRFQ------PELSAP---------------- -------------DLRRFIDGPNRAVAL---------LPELREVV-SSISYIARQLQ--EQEDHDALKEDWQ FV----------------------------AMVVD---RLFLWTFIIFTSVGTLVIFLDAT----YHLPPPD PFP-------------- >nAChRalpha1 -----------SEHETRLVAKLF---KDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ GDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF TKVL--LQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD---Q-------- -PDL-SNFMESGEWVIKESRGWKHSVTYSCC--PDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLV FYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH-RS PST-HVMPNWVRKVFIDTIPNIMFFSTMK-RPS-----------------------REKQ-------DKKIF TE---------------------------------------------------------------------- -------------------------------DID--ISDISGKPG--------------------------- ----------------PPPMGFHSPLIK---------HPEVKSAI-EGIKYIAETMK--SDQESNNAAAEWK YV----------------------------AMVMD---HILLGVFMLVCIIGTLAVFAGRLIE--LNQ---- ---------------QG >nAChRdelta -----------LNEEERLIRHLF-QEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEH -------------------------GWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYS CNVL--VYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWI IIDP-EGFTENGEWEIVHRPARVNVDPRAPL--DSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLV FYLPADS-GEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHF-RT PST-HVLSEGVKKLFLETLPELLH---MS-RPA-----------------------EDGP-------SPGAL ------------------------------------------------------------------VRRSSS LGYISKAEEYF------------LLKSRS--DLM--FEKQSERHGL----ARRLTT---------------- -------------ARRPPASSEQAQQEL---------FNELKPAV-DGANFIVNHMR--DQNNYNEEKDSWN RV----------------------------ARTVD---RLCLFVVTPVMVVGTAWIFLQGV----YNQPPPQ PFPGDPYSYNVQDKRFI >nAChRepsilon -----------KNEELRLYHHLF---NNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGI -------------------------DWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYD ANVL--VYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVD---NDGKTINKI DIDT-EAYTENGEWAIDFCPGVIRRHHGGAT--DGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLA YFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQ-RT PTT-HAMSPRLRHVLLELLPRLLG---SP-PP------------------------PE---------APRAA SP----------------------------------------------------------------PRRASS VGLLLRAEELI------------LKKPRS--ELV--FEGQRHRQGT-------------------------- -------------WTAAFCQSLGAA------------APEVRCCV-DAVNFVAESTR--DQEATGEEVSDWV RM----------------------------GNALD---NICFWAALVLFSVGSSLIFLGAY----FNRVPDL PYAPCIQP--------- >nAChRgamma -----------RNQEERLLADLM---QNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEM -------------------------QWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALY CNVL--VSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQ----EDGQTIEWI FIDP-EAFTENGEWAIQHRPAKMLLDPAAPA--QEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILI HFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSL-RS PHT-HSMARGVRKVFLRLLPQLLR---MHVRPL----------------------------------APAAV QD---------------------------------------------------------TQSR---LQNGSS GWSITTGEEVA------------LCLPRS--ELL--FQQWQR-QGLVAAALEKLEKGPE------------- ------------LGLSQFCGSLKQA------------APAIQACV-EACNLIACARH--QQSHFDNGNEEWF LV----------------------------GRVLD---RVCFLAMLSLFICGTAGIFLMAH----YNRVPAL PFPGDPRPYLPS---PD >Banc81 -----------SETEERLLEKLF---KNYNLKVRPARTVGDRVTVRVGMTLSQLISLNEKDEEMTTNVFMDL -------------------------AWTDYRLSWNPAEYEGIKSLRIPSDKVWLPDIVLMNNNDGNFEVALH VNVL--VYHDGTVNWLPPAIYRSSCSIKVTYFPFDWQNCTMVFRSYTYDASEIDLQHALD---EDGQEIKEI IIDE-DAFTENGQWEIRHKPSRKNVLPDDPL------YEDITFYLIIQRKPLFYIINIIIPCILISILAILV FYLPPDA-GEKMTLSISVLLALTVFLLLLADKVPETSLGVPIIVKYLMFTMILVTFSVILSVVVLNLHH-RS PNT-HTMPLWVRQIFIEMLPRYLG---MQ-RPK-----------------------PEPPL------EPEPP RK----------------------------------------------------------------PKENTP RISNRAADEYF------------IRKPNS--DFI--FPKPNRFQ------PERLST---------------- -------------DLRRFIDGLSHCLTL---------PPDLKSAI-DAVKYIAEQLQ--KQNDYDALKEDWQ YV----------------------------AMVVD---RLFLWIFIIFCSLGTLGIFLDAS----FNHPPED PFP-------------- >BancS -----------SDTEDRLLNKLF---RNYNPNVRPARTLGDKVTVRVGLTLSQLISLNEKDEEMTTNVFLNL -------------------------EWTDYRLQWDPADYEGIKSLRIPSDKVWLPDIVLMNNNDGNFEITLH VNVL--VNHDGTVRWQPPAIYRSSCSIEVTYFPFDWQNCTMVFRSYTYDSSEITLQHALD---EEGREIKEI IIDE-DAFTENGQWEIRHKPSRKNWLPDDPS------YEDITFYLIIQRKPLFYIINIIIPCILISILAILV FYLPPDA-GEKMTLSISALLALTVFLLLLADKVPETSLAVPIIVKYLMFTMILVTFSVILSVVVLNLHH-RS PNT-HTMPNWVRQIFIEKLPRFLG---LQ-RPK-----------------------PEP------------- ------------------------------------------------------------------SPDSTL RLSNRATDEYF------------IRKPAG--DFI--FPKDNRFQ------PERLST---------------- -------------DLRRFLDGLSHSVTL---------PPDLKSAI-DAVKYIAEQLQ--EQNDYDNLKEDWQ YV----------------------------AMVVD---RLFLWIFITVCSLGTLSIFLDAS----YNHPPAD PFP--------------