mmHg Vehicle (V) PRS Vehicle PRS NCDO 2118 + Glutamate (PRS LG) PPRS NCDO 2118 Delta + glutamate (PRS LD) 0 3 5 2 3 0 1 0 0 0 0 0 0 0 6 7 1 0 4 0 11 9 4 0 6 1 4 1 4 0 0 0 0 0 0 0 2 6 2 3 0 0 0 0 1 2 9 4 11 2 0 2 9 2 15 7 6 6 11 13 9 6 0 1 0 7 4 6 17 21 4 30 3 10 5 15 1 1 5 8 5 2 7 21 4 3 6 0 1 3 3 7 0 0 2 7 17 3 6 13 9 5 4 3 0 2 0 4 30 14 8 18 14 12 10 12 10 10 13 25 7 11 26 34 31 43 5 10 63 21 17 13 35 16 47 3 10 29 23 18 21 6 10 5 10 7 0 2 2 30 21 18 30 35 14 8 12 12 12 17 13 3 45 11 10 21 21 12 11 18 22 10 17 25 15 16 37 50 44 48 19 33 65 32 23 37 54 37 55 8 15 23 26 44 31 15 10 5 23 14 29 2 23 31 24 11 38 44 10 27 17 42 54 57 52 23 60 11 14 24 33 16 21 31 24 16 20 32 35 24 33 61 42 50 46 50 66 49 29 53 65 50 58 8 22 21 40 48 36 24 12 10 24 27 42 22 46 38 25 12 75 63 27 33 28 50 49 66 63 45 FIGURE 3A Source data