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------------------------------------------------------------ --------SLDARLGV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------DT----------------- -R----------------------L--------------------------W-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A--------K----V------------------------ -------------------------------L-----------------------FTA-- --L------------------------------------------------------YA- LI-------WA--LGAAGNALSAHV------------------V------L--------- ---K-------------------------------------A-----R----A------- 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------------------------------------------------- >Bilateria_human_sp__P21452__NK2R_Substance-K_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GTCDIVTEAN------------------------------------------ --------------------------------------------------ISSGPE---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------TTGIT------------------------------------------------- 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------------------------------------------------------------ ---------------------------------------------VELQA---------- ---------------------------K-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P21730__C5AR1_C5a_anaphylatoxin_chemotactic_receptor_1 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P24530__EDNRB_Endothelin_receptor_type_B ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-Q----------------- ------------------------------------------------------------ ----------------------------PPPSLCGRALV--------------------- ------------------------------------------AL---------------- VL-------------ACG------------------------------------------ --------------------------------------------------LSRIWGEER- ------------------------------------GFPPDRATPLLQTAEIMTPPTKT- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P25024__CXCR1_C-X-C_chemokine_receptor_type_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SN------------------------------------------ --------------------------------------------------IT-------- ------------------------------------------------------------ -------DPQMWDFD--D------------------------------------------ -----------------------------------------------LN----------- ------------------------------------------------------------ ------------------------------------------------------------ -----FTGMPP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ADEDYSPCML------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NL---------- >Bilateria_human_sp__P25025__CXCR2_C-X-C_chemokine_receptor_type_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- -------------D---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FN------------------------------------------ -----------------------------------------------MESDS-------- ------------------------------------------------------------ -------FEDFWKGE--D-L---------------------------------------- -----------------------------------------------SN----------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P25089__FPR3_N-formyl_peptide_receptor_3 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TN------------------------------------------ --------------------------------------------------FSIP------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LN----------- ----------------------E------------------------------------- ------------------------------------------------------------ ------TEEVL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PE----------------- 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------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P25090__FPR2_N-formyl_peptide_receptor_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TN------------------------------------------ --------------------------------------------------FSTP------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LN----------- ----------------------E------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P25101__EDNRA_Endothelin-1_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ -------------------------------TLCLRASF--------------------- ------------------------------------------WL---------------- AL-VGCVISDNPERYSTN------------------------------------------ --------------------------------------------------LSNHVDDFT- ------------------------------------TFRGTELSFLVTTHQ----PTNL- -------------------------------------------------------VLP-- -----------------------------------------------SN----------- ----------------------G------------------------------------- ------------------------------------------------------------ ------SMHNY------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPQ------------------ ------------------------------------------------------------ ------------------------------QT---------KI----------------- -T----------------------S--------------------------A-------- ------------------------------------------------------------ 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>Bilateria_human_sp__P25103__NK1R_Substance-P_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------DNVLPVD------------------------------------------ --------------------------------------------------SDLSPNIS-- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------TSEPN------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QF---------VQ----------------- -P----------------------A--------------------------W-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q--------I----V------------------------ -------------------------------L-----------------------WAA-- --A------------------------------------------------------YT- VI-------VV--TSVVGNVVVMWI------------------I------L--------- ---A-------------------------------------H-----K----R------- --------M--------------------------------------------------- ----------------R------------T---------V-TN------Y-FLVNLAFAE ASMAAFN-------------------------------------------------TVVN 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------D---------------------------------- ---------------R-------------Y----------------H------------- -----------E----------------------------Q------------------- -V------S-----------A---KR---K-----------------------VV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KMM---IVVVCTFAIC-- ---------W-----LPFHIFF---------------------------LLP-Y------ ----------------------------I---N--------P--D---L----------- --Y--------------------------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P25105__PTAFR_Platelet-activating_factor_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------P----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------HD----------- ---------------------SS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------H---------MD----------------- -S----------------------E--------------------------F-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R--------Y----T------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P28336__NMBR_Neuromedin-B_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PSKSLSN------------------------------------------ --------------------------------------------------LSVTTG---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AN----------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P30518__V2R_Vasopressin_V2_receptor ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MLM------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------TASS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SLAKDTSS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P30550__GRPR_Gastrin-releasing_peptide_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- -----------ALN---------------------------------------DCF---- ------------------------------------------------------------ ------------------------------------------------------------ ---------------LLN------------------------------------------ --------------------------------------------------LEVDHFMH-- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------CN----------- ------------------------------------------------------------ ------------------------------------------------------------ -----ISSHSADLPVNDDW----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RY---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------V---------- >Bilateria_human_sp__P30556__AGTR1_Type-1_angiotensin_II_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------STKKPAPCFEVE------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P30559__OXYR_Oxytocin_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GALAAN------------------------------------------ --------------------------------------------------WS-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AEA-AN----------- ---------------------ASAAPP--------------------------------- ------------------------------------------------------------ GAEGNRTAGPP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ -------V-----------------S---------------------------------- ---------------S-------------V----------------K------------- -----------L----------------------------I------------------- -S------K-----------A---KI---R-----------------------TV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KMT---FIIVLAFIVC-- ---------W-----TPFFFVQ---------------------------MWS-V------ ----------------------------W---D--------A--N---A----------- --P--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------K----E --------------------------A--------------S-AF--------------- ------------------------I-IVML------------------------------ 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------------------------------------------------------------ ----------------------------------------SSFV---------------- ------------------------------------------------------------ -------------------------L---------------------------------- ------------------------------------------------------------ -------------------SHRSS------------------------------------ ----------------------------------------------SQRS---------- ---------------------------CSQPSTA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P30872__SSR1_Somatostatin_receptor_type_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ -----------------------------FP----------------------------- ------------------------------------------------------------ -----------------N------------------------------------------ -------------------------------------------------GTASSP----- -------------------------------------------SSSPSPS---------- ---------------------------------------------------------PGS ----------------------------------CGEGGGSRGPGA-------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------A---------------------------------- ---------------G-------------W----------------Q------------- -----------Q----------------------------R------------------- -K------R-----------S---ER---K-----------------------IT----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LMV---MMVVMVFVIC-- 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------------------------------------------------------------ ------VEDFQPENLES------------------------------------------- ------------------------------------------GGVFRN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GT---------- ------------------------------------------------------------ ----CTS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------RITTL---------- >Bilateria_human_sp__P30874__SSR2_Somatostatin_receptor_type_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P32246__CCR1_C-C_chemokine_receptor_type_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ET-------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VI---------- >Bilateria_human_sp__P49685__GPR15_GPCR_15 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-D----------------- ------------------------------------------------------------ ------------------------------P----------------------------- ------------------------------------------------------------ ----------EETSVYLD------------------------------------------ --------------------------------------------YYYA--TS-------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P51582__P2RY4_P2Y_purinoceptor_4 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STESSLLRS- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LGL---------- ----------------------S------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RL---------- >Bilateria_human_sp__P51677__CCR3_C-C_chemokine_receptor_type_3 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-T----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TS-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LD----------- ------------------------------------------------------------ ------------------------------------------------------------ -----TVETFG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TTSYYDD------------- -----------------------------------VGLLCE------------------- ------------------------------------------------------------ ------------------------------KA---------DT----------------- -R----------------------A--------------------------L-------- 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------------------------------------------------- >Bilateria_human_sp__P51679__CCR4_C-C_chemokine_receptor_type_4 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------N------------------------------------------ --------------------------------------------PTDIADTTLDESIY-- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P51681__CCR5_C-C_chemokine_receptor_type_5 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-DYQV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SS-------- ------------------------------------------------------------ ---------------------------------------------------------PIY D----------------------------------------------IN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------YYTSEPCQ------------------- ------------------------------------------------------------ ------------------------------KI---------NV----------------- -K----------------------Q--------------------------I-------- ------------------------------------------------------------ ------------------------------------------------------------ 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T-F----GVVTSVITWVVAVFA-S-LPGI---IF---T--R-------------S----- Q----------------------K------------------------EG---------- -----------------------------------------------------L------ ---------------------------------------------------H-------- --------Y---------T------------CS-------------------S----H-- --------------------------F---------------P--------Y------SQ Y----------------------------------------Q------------------ -F---------------W---------------K-N---F-----QT------------- -----------LK-IV-----ILGLVLPLLVM------VICYSGILK------------- --------------------------TL----L------------------R-------- -----------------------C--------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------RASS---------- ---------------------------VYTRSTGEQEISVGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__P51684__CCR6_C-C_chemokine_receptor_type_6 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SGESMN------------------------------------------ --------------------------------------------FSDVFDSS-------- ------------------------------------------------------------ --------EDYFVS---------------------------------------------- -----------------------------------------------VN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------TSYYS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------M---------- >Bilateria_human_sp__P51685__CCR8_C-C_chemokine_receptor_type_8 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-D----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YT-------- ------------------------------------------------------------ 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----------------------------------------M------------------- ------------------------------------------------------------ -----------------------------TPTDF-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TS-------- ------------------------------------------------------------ ---------------------------------------------------------PI- -----------------------------------------------PNMA--------- ------------------DDYGS------------------------------------- ------------------------------------------------------------ ----ESTSSMED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------YVNFNF------------- -----------------------------------TDFYCE------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -K------S-----------S---KH---K-----------------------AL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KVT---ITVLTVFVLS-- ---------Q-----FPYNCIL---------------------------LVQ-T------ ----------------------------I---D--------A--Y---A----------- --MFI------------------------------------------------------- -----------------------------------------------SN----------- ------------------------------------CA---------------VS----T ------N---------------I---D--------------I-CF--------------- ------------------------Q-VTQT------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------L---------- >Bilateria_human_sp__P55085__PAR2_Proteinase-activated_receptor_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MRSP---------------- -------------SAAWLLGAAI-------------------LL---------------- --------------A--------------------------------------------- ------------------------------------------------------------ -----ASLSCSGTIQGTN------------------------------------------ --------------------------------------------------RSSKGRSLIG K----------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------VDG---------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------Y---------- >Bilateria_human_sp__P61073__CXCR4_C-X-C_chemokine_receptor_type_4 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-EGISIY------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TS-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DN----------- ------------------------------------------------------------ ------------------------------------------------------------ -----YTEEMG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SG----------------------DYDS------------- -----------------------------------MKEPCF------------------- ------------------------------------------------------------ ------------------------------RE---------EN----------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -G------H-----------Q---KR---K-----------------------AL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KTT---VILILAFFAC-- ---------W-----LPYYIGI---------------------------SID-S------ ----------------------------F---I--------L--L---E----------- --IIK------------------------------------------------------- -----------------------------------------------QG----------- ------------------------------------CE---------------FE----N ------T---------------V---H--------------K-WI--------------- ------------------------S-ITEA------------------------------ ---------LAF------------------------------------------------ --------------FHCCL-NP-----ILY---------AF------------------- 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------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q13304__GPR17_Uracil_nucleotide_cysteinyl_leukotriene_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-SKRSWW------------ ------------------------------------------------------------ --------------AG-----------SRKPPREM------------------------- ------------------------------------------------------------ -----LKLSGSDSSQSMN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GL----------------------------------EVAPPG LI---------------------------------------------TNF---------- ----------------------S------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------LATAEQCG------------------- ------------------------------------------------------------ -----------------------------------------QE----------------- -T----------------------P--------------------------L-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E--------N----M------------------------ -------------------------------L-----------------------FAS-- --F------------------------------------------------------YL- LD-------FI--LALVGNTLALWL------------------F------I--------- ---R-------------------------------------D-----H----K------- --------S--------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------V----------------------------E------------------- -K------R-----------L---KT---K-----------------------AV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RMI---AIVLAIFLVC-- ---------F-----VPYHVNR---------------------------SVY-V------ ----------------------------L---H--------Y--R---S----------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------KSEL---------- >Bilateria_human_sp__Q14330__GPR18_N-arachidonyl_glycine_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ITLN------------------------------------------ --------------------------------------------------NQ-------- ------------------------------------------------------------ -------------------------------------------------------DQPV- --------P--------------------------------------FN----------- ----------------------S------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SH----------------- -P----------------------D--------------------------E-------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------S----------------K------------- 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--------------------Q-------------------------------------AR -------------V-------------------I-------------------------- --------------------------------------S--------------------- --------------------V-------------M------------------------- ------------------------------------------------------------ -----------------------------------------------------------L YRNYLRS----------------------------------------------------- ------------------------------------------------------------ -----------------MRRKS-----------------------------F-------- ------------------------------------------------------------ ------------------------------------------------------------ -----RSGSLR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SLSN---------- ---------------------------INSEML--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q15077__P2RY6_P2Y_purinoceptor_6 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------W------------------------------------------------ -----------------------------------------------DNG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------TGQAL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------G--------------------------------------- ----------------------------------LPPTTC-------------------- ------------VY---------------------------------------------- ------------------------------------------R----------------- -E----------------------N--------------------------F-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------K--------Q----L------------------------ -------------------------------L-----------------------LPP-- --V------------------------------------------------------YS- AV-------LA--AGLPLNICVITQ------------------I------C--------- ---T-------------------------------------S-----R----R------- --------A--------------------------------------------------- ----------------L------------T---------R-TA------V-YTLNLALAD LLYACS--------------------------------------------------LPLL 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-----------MA-LT-----VIGFLLPFAAL------LACYCLLAC------------- --------------------------RL----C------------------R-------- -----------------------Q--------D------------G-------------- --------------P--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------A-------------E----------------P------------- -----------V----------------------------A------------------- -Q------E-----------R---RG---K-----------------------AA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RMA---VVVAAAFAIS-- ---------F-----LPFHITK---------------------------TAY-L------ ----------------------------A---V--------R--S---T----------- --PGV------------------------------------------------------- ------------------------------------------------P----------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q15391__P2Y14_P2Y_purinoceptor_14 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------M-IN----------- ----------------------S------------------------------------- ------------------------------------------------------------ ------TSTQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPDESCS------------------- ------------------------------------------------------------ -----------------------------------------QN----------------- -L----------------------L--------------------------I-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T--------Q----Q------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------K---------------------------------- ---------------S-------------S----------------R------------- -----------N----------------------------S------------------- -T------S-----------V---KK---K-----------------------SS----- 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----------------------------------------------TLES---------- ---------------------------TDTL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q15722__LT4R1_Leukotriene_B4_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------N------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------T------------------------------------- ------------------------------------------------------------ ------TSSAAP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q15743__OGR1_Ovarian_cancer_GPCR_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GN------------------------------------------ --------------------------------------------------IT-------- -----------------------------------A------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------T----------------------------Q------------------- -K------S-----------R---KD---Q-----------------------IQ----- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------------------------AFLTC------------------------------ -SRT-------------------------------------------------------- ---------------------------------------GR------------------- -----------------AREAYPLGAPEASG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----KSGAQGEEPELLTKLHP-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------AFQT---------- ---------------------------PNSPGSGGFPT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRLA--------- >Bilateria_human_sp__Q15760__GPR19_Probable_GPCR_19 M----------------------------------------------------------- ------------------------------------------------------------ -----------------------------------VFAHRM-D----------------- -------------NSKPHLII--------------------------------------- ------------------------------P----------------------------- ------------------------------------------------------------ ----------TLLVPLQN------------------------------------------ --------------------------------------------------RS-------- ----------------------------------------CTETATPLPSQYLM------ ------------------------------------------------------------ -------------------------------------ELSEEHSWM-SN----------- ----------------------Q------------------------------------- ------------------------------------------------------------ ------TDLHYVLK---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------R-----------------R---------------------------------- ---------------T-------------M----------------N------------- -----------I----------------------------V------------------- -P------R-----------T---KV---K-----------------------TI----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KMF---LILNLLFLLS-- ---------W-----LPFHVAQ---------------------------LWH-P------ ----------------------------H---E--------Q--D---Y----------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K ------K---------------S---S--------------L-VF--------------- ------------------------T-AITW------------------------------ ---------ISF------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q16581__C3AR_C3a_anaphylatoxin_chemotactic_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------S-------- ------------------------------------------------------------ -----------F------------------------------------------------ -------------------------------------------SAE-TN----------- ----------------------S------------------------------------- ------------------------------------------------------------ ------TDLLSQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------P------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ WN----------------------E--------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P--------V----I------------------------ -------------------------------L-----------------------SMV-- --I------------------------------------------------------LS- LT-------FL--LGLPGNGLVLWV------------------A------G--------- ---L-------------------------------------K-----M----Q------- ------------------------------------------------------------ ----------------R------------T---------V-NT------I-WFLHLTLAD LLCCLS--------------------------------------------------LPFS ----------------------------------L------AHL-A-L----Q----G-- ---------------------------Q-----W-------------------------- ------------------P--------Y-------------------------------- ----------------------------G----RF-L----CK-LIPS------------ --------I-IVLNMFA-------------SVFLLTAISLDR------------------ ------------------------------------------------------------ -------------------------------------------------CLV--V-F--- -K------P-I-W-C--------Q---N-------H--R-N-V----------------- G-M----ACSICGCIWVVAFVM-C-IPVF---VY---R--E-------------I----- F----------------------T------------------------TD---------- -----------------------------------------------------N------ ---------------------------------------------------H-------- --------N---------R------------CGYKFGLSSSLDYPDFYGDPLE----NRS 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------F------------------- -A------K-----------S---QS---K-----------------------TF----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RVA---VVVVAVFLVC-- ---------W-----TPYHIFG---------------------------VLS-L------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q49SQ1__GPR33_Probable_GPCR_33 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-DLI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------NSTDYLIN------------------------------------------ --------------------------------------------------AS-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TLV-RN----------- ----------------------S------------------------------------- ------------------------------------------------------------ ------TQFLA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -P-------------------------------------------------A-------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SVER---------- ---------------------------TQT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q6W5P4__NPSR1_Neuropeptide_S_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------P----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ANFTE-------- ------------------GSFDS------------------------------------- ------------------------------------------------------------ ----SGTGQTLDSSPV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AC-------------------- ------------------------------------------------------------ -----------------------------------------TE----------------- -T-------------------VTFTEVVE--------GKEWG-----SFYYS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------F--------K----T------------------------ -------------------------------E-----------------------QLI-- --T------------------------------------------------------LW- VL-------FV--FTIVGNSVVLFS------------------T------W--------- ---R-------------------------------------------R----K------- --------K--------------------------------------------------- ----------------K------------S---------R-MT------F-FVTQLAITD 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------L-C- ------------------------------------------------------------ ------------------------------------------------------------ ------SS-----------------Y---------------------------------- ---------------N-------------R----------------G------------- -----------L----------------------------I------------------- -S------K-----------A---KI---K-----------------------AI----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KYS---IIIILAFICC-- ---------W-----SPYFLFD---------------------------ILD-N------ ----------------------------F---N--------L--L---P----------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------P-------- ------------------------------------EF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------I---------- >Bilateria_human_sp__Q86VZ1__P2RY8_P2Y_purinoceptor_8 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-Q----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VPN------------------------------------------ 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R-Y----AVAACAGTWLLLLTA-L-SPLA---RT---D--L-------------T----- Y----------------------PV-----------------------HA---------- -------------------------------------L---------------G------ ---------------------------------------------------I-------- --------I---------T------------CF-------------------D----V-- --------------------------L---------------K--------W------TM LP------------------------------------S--V------------------ -A---------------M---------------W-A---V-----FL------------- -----------FT-IF-----ILLFLIPFVIT------VACYTATIL------------- --------------------------KL----L------------------R-------- -----------------------T--------E--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------E----------------A------------- -----------H----------------------------G------------------- 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----------------Q------------------------------------------- ----------------------------------------------RQES---------- ---------------------------V-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------F---------- >Bilateria_human_sp__Q8IYL9__PSYR_Psychosine_receptor ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-N----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------STCIE------------------ ------------------------------------------------------------ -----------------------------------------EQ----------------- -H----------------------D--------------------------L-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D--------H----Y------------------------ -------------------------------L-----------------------FPI-- --V------------------------------------------------------YI- FV-------II--VSIPANIGSLCV------------------S------F--------- ---L-------------------------------------Q-----A----K------- --------K--------------------------------------------------- ----------------E------------S---------E-LG------I-YLFSLSLSD LLYALT--------------------------------------------------LPLW ----------------------------------I------DYT-W-N----K----D-- 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--------------------------AV----R------------------H-------- -----------------------N--------K------------A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------T----------------------------E------------------- -N------K-----------E---KK---R-----------------------II----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KLL---VSITVTFVLC-- ---------F-----TPFHVML---------------------------LIR-C------ ----------------------------I---L--------E--H---A----------- --VNFED----------------------------------------------------- ---------------------------------------------H--S----------- -------------------------------------N---------------SG----K ------R---------------T---Y--------------T-MY--------------- ------------------------R-ITVA------------------------------ ---------LTS------------------------------------------------ --------------LNCVA-DP-----ILY---------CF------------------- --------------------------------------V--------------------- -------------------------TE-----T-----------------------G--- --------------------R-------------------------------------YD -------------M-------------------W-------------------------- --------------------------------------N--------------------- --------------------I-------------L------------------------- -----------KF----------------------------------------------- -----------------------------CTG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RCNTSQRQRKR-------------------------------------------- ------------------------------------------------------------ ----------IL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SVST---------- ---------------------------KDTMELEVLE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q8NFJ6__PKR2_Prokineticin_receptor_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AQN-------------------------------------GN--- --------------------------------------------------TSFTPN---- ------------------------------------------------------------ -------------------------------------------------------FNPP- --------------------------------------QDHASSLS-FNF---------- ----------------------S--------------------------------Y---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GD---------------YD LPMD--E-------------DEDMTKTR--------------------TFFA-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A--------K----I------------------------ -------------------------------V-----------------------IGI-- --A------------------------------------------------------LA- GI-------ML--VCGIGNFVFIAA------------------L------T--------- ---R-------------------------------------Y-----K----K------- --------L--------------------------------------------------- ----------------R------------N---------L-TN------L-LIANLAISD FLVAIIC-------------------------------------------------CPFE ----------------------------------M------DYY-V-V---RQ----L-- ---------------------------S-----W-------------------------- ------------------E--------H-------------------------------- ----------------------------G----HV-L----CA-SVNY------------ --------L-RTVSLYV-------------STNALLAIAIDR------------------ ------------------------------------------------------------ -------------------------------------------------YLA--I-V--- -H------P-L-K-P--------R---M------------N-Y----------------- Q-T----ASFLIALVWMVSILI-A-IPSA---YF---A--TETV-------LF-I----- V----------------------K------------------------SQ---------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q92847__GHSR_Growth_hormone_secretagogue_receptor_type_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MWN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ATPSEEPGFN------------------------------------------ --------------------------------------------------LT-------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q99527__GPER1_G-protein_coupled_estrogen_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-DV---------------- -------------TSQARGVG--------------------------------------- --------------------------LEMYPG---------------------------- ------------------------------------------------------------ ----------TAQPAAPN------------------------------------------ --------------------------------------------------TT-------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------EREPSSGDV---------------------------------- -VSMH------------------------------------------------------- ------------------------------------------------------------ -----RSSKGSGRHHILSAGPH-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ALTQ---------- ---------------------------ALANGPEA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q99705__MCHR1_Melanin-concentrating_hormone_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-SVGAMKKGVGR-AVGLGG GSGCQATEEDPLPNCGACAPGQ-------------------------------------- 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------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q99788__CML1_Chemokine-like_receptor_1 MR---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------M-E----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DEDYN------------------------------------------ --------------------------------------------------TSISYGD--- ------------------------------------------------------------ -------------------------------------------------------EYPD- --------------------------------------YLDSIVVL-EDL---------- ----------------------S------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ML---------- >Bilateria_human_sp__Q9BPV8__P2Y13_P2Y_purinoceptor_13 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-TA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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>Bilateria_human_sp__Q9BXA5__SUCR1_Succinate_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGIMAWN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q9BXC0__HCAR1_Hydroxycarboxylic_acid_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----C------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q9BY21__GPR87_GPCR_87 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MGFNLTLAKLPN------------------------------------------ --------------------------------------------------NE-------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q9NYM4__GPR83_Probable_GPCR_83 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ----------------------------------------------------------V- PHL-LLLCLLPL-------------VRATEPHEGR------------------------- ------------------------------------------------------------ ----ADEQSAEAALAVPN------------------------------------------ --------------------------------------------------AS-------- ------------------------------------------------------------ ---------HFFS----------------------------------------------- --------------------W--------------------------NN----------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q9P296__C5AR2_C5a_anaphylatoxin_chemotactic_receptor_2 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-G----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_human_sp__Q9Y271__CLTR1_Cysteinyl_leukotriene_receptor_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-D----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------SHKPHEKGATV- --------------NGGDTEE-------------RAAF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_Drosophila_sp__Q9VML9__TRISR_Trissin_receptor_TrissinR MI---------------------------------------------------------- ------------------------------------------------------------ -------------------------------------MTMM-Q----------------- -------------TVRAWQQESDVEHR--------------------------------K QHK-----------------------QRWRPDG--------------------------- ------------------------------------------------------------ --------AHISAAYDLNSDND-------------------------------------- DGH--------------------------------------HRVVHNQNNGSPN------ -------------------------------------------SSPNQSTSAFRQRQPHH 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Bilateria_Drosophila_tr__Q9VRM0__Q9VRM0_GPCR_F1_2_Lkr MA---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------M-DLIEQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ESRLEFL--- ------------------------------------------------------------ ---------------------------------------------------------P-- ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------SLHG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------I------------------QHVRHNSCEQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TY---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------I---------- >Outgrp_Bilateria_Platynereis_Contig7183 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E-------------G--- -------------NLTSA------------------------------------------ -------------------------NYTAEPS---------------------------- ------------------------------------------------------------ ---------------SVNLTTTP---------------FP-------------------- -------------------------------------------DYINIDNLTFGEAEV-- ------------------GL---------------------SVLEHNGSYSDCVEFSG-- ------------------------------------------------------------ -----------------------------------------------GN----------- ---------------------ASAC------------------------------W---- --------------------------------------------GVA------------- ----NYTNGTSPFSD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__P20905__5HT1R__5-HT7 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-ALSGQDWR-R-------- -----HQSHRQHRNHRTQGNHQKLIST------------ATLTLFV-------------- ----LFLSSWIAYAAGK--------ATVPAPLV--------------------------- ------------------------------------------------------------ -----EGETESATSQDFNSSSAF------------------------------------- --------------------------------------------LGAIASAS-------- -------------------------------------------STGSGSGSGSGSGSGSG 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------------------------------------------------------------ ------RHSSVGNTSLTYSTCGGLSSG-----------------GGAL------------ ------------------------------------------------------------ ----------------------------------------------------AGHGSGGG VSGST------------------------------------------------------- ---------------------------------------------GLLGSPH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------HK---------------------------------- ---------------K-------------L----------------R------------- -----------F----------------------------Q------------------- -L------A-----------K---EK---K-----------------------AS----- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------F---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------L---------- >Outgrp_Bilateria_Platynereis_comp417561_c0_seq1 ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Anthozoa_Aiptasia_AIPGENE19008_p1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-S----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NN----------- 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-----------------------------------------------------------E VESKVAKSPKSSAKRLHVSPSPD------------------------C------------ -------------------SRKNI----------------DDDSISENAATD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTLL--------- >Outgrp_Bilateria_human_sp__P25100__ADA1D__Alpha-1D_adrenergic_R_ADRA1D ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-T----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRDLLSVSFEGP---- ----------------------------------------RPDSSAGGSSAGGGGGSAGG AAP-----------------------------------------SEGPA----VGGVPGG AG--------------------------------GGGGVVGAGSGE-DNRSSA------- -----GEP-------------GSAGA---------------------------------- -------------------------------------------GGDV------------- ----NGTAAVGGLVV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------------------------------------------VVLRIHCR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GAATGADGAH--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MRSAKG-------------------- 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------------------------------------------------------------ --------------------------------------I---------- >Outgrp_Bilateria_Drosophila_tr__Q9VEG2__TyrRII_ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-A----------------- ------------------------------------------------------------ --------------------------ALEHPDAMLP------------------------ ------------------------------------------------------------ ---YSKLLSTALTVASGN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SN----------- ----------------------SSD----------------------------------- --------------------------------------------GTL------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Celegans_tr__Q7JNP9 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-AIWWWF------------ ----------EILSAKSDFESIM------------------------------------- -------A-W-------------------------------------------------- ------------------------------------------------------------ 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>Outgrp_Bilateria_Platynereis_Contig15090 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- -------------ETPRPTPE----------------------L---------------- ------------------------------P----------------------------- ------------------------------------------------------------ -----------HFDPMAN-------------------------------------G---- --------------------------------------------------WT-------- ------------------------------------------PSFREAALQPMADIPSED WP-------------------------PANDAAAIIG----GQLNNNVT----------- --------------------------------------TSEGLSMA-LN----------- ----------------------M------------------------------------- ------------------------------------------------------------ ------SNHTVTPFI--------------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__P22270__OAR__Tyramine_octopamine_Oct-TyrR ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M------------------- ------------------------------------------------------------ ------------------------------PSA--------------------------- ------------------------------------------------------------ -----------DQILFVNVTT--------------------------------------- --------------------------------------------TVAAAALTAAAAV--- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Platynereis_APC23183_1_octopamine_R_1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E--------R-------- ------------------------------------------QV---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GN----------- ---------------------RSCVM---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Celegans_tr__O44986 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-E----------------- ----------WMRNT----------------------------L---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------NGQFIAENSD--------------------------------------F- --------------------------------------------------LS-------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AAVTFNTPTN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__P28286__5HT2B__5H-T1B_ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MLK----------------- ------------------------------------------TVTT-------------- --------------AMA-------AGDDDVPAS--------------------------- ------------------------------------------------------------ ------ILEIELPAILLN------------------------------------------ --------------------------------------------ESLFIELN-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GNLT--------- ------------------------------------------------------------ ------------------------------------------------------------ -QLVDTTSNLSQIVWNRSIN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GNGNSNT-F--------------------------------- ------------------------------------------------------------ ---DLVDD---------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ERIMWL------- >Outgrp_Bilateria_Platynereis_Contig3801 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-A----------------- -------------EMAAA------------------------------------------ ----------------------------DVPYG--------------------------- ------------------------------------------------------------ --------MSDGTIHYAN---------------------------CC-----VAGG---- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__P28285__5HT2A__5-HT2A_ ------------------------------------------------------------ ------------------------------------------------------------ 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---------------------------------LPMLL-NEREFGNSS----TPRSSLES LSENVNVITNDFVSEN------------CTTFSRR------SSYADDSQPTSSQTSSGDG RSYSIKGQKRFRNLSRNYS------TKHHRKVVKVNRGNSRNNSRTASITNQSDDAL-IP AIIR-----TISRKSPR-----LFRRDKTD----------IKKHSMILANPITEPPKEYR RV---------------------------------------------------------- -----------------------------------------SMPIHPTNSQT-------- ----------ETETISASRDIENLPTTTISRSTTANSAELLGS----PDDFEKFPALITE TVLEDVLAETREGCFMQPTVSFALTVREME------GNALNNLKGCSVESSRRVSQVDPP LAIQILTRPSLPHLDLQRMDSIGTTCSSKTRADSLRSVDS-------------------- --KGSKKS------NRNGIAVKLVKR--------AI------------------------ ---K------HEHSLK-------------R----------------KVS----------- -----------K----------------------------A------------------- -Q------R-----------K---EK---R-----------------------AT----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KTL---GVVVGVFLVC-- ---------W-----VPFFVIN---------------------------ILN-A------ ----------------------------V---CI---LLNKD--S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------C----------------------Q ------V---------------G---Y--------------D-LF--------------- ------------------------F-YCTW------------------------------ ---------IGY------------------------------------------------ --------------MNSFM-NP-----IIY---------TI------------------- --------------------------------------F--------------------- -------------------------NT-----E-----------------------F--- --------------------R-------------------------------------RA -------------F-------------------K-------------------------- --------------------------------------S--------------------- --------------------I-------------I------------------------- -----------F---------------G-------------------------------- ------------------------------------------------------------ -RN-------------------ST------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RHHFSNKQAH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------V---------- >Outgrp_Bilateria_Platynereis_Contig8734 MKSVA--------------------------------------DLFRTL----GTSPE-- -----------------SRPDLNISGVPSNIAED-----------------------AQH G----LNS--------AAFKTVTEHGSLSPPGNL------MGNVTYNFPR---------- -------------NANSSWQD----------------------L---------------- -----------------------------GPLAQNDSVIET------------------- ----------------------LDDTAASAL--GTLNNTLRDAL---------------- N--DAFGFFTSSNNNSFNVTAKTIDVTAPHRISTASTWQPSITDR--------ASGV--- ------------------------------------------QETSYQVASSEQAH---- -------------------------------------VALGANTAGAATTSLLGEGLGTG STWPHQPAQTPFSSSPGDAL-------QRTVSEAVSSVLGTAGPQEGSASTHTTAGTPPE LS---------LNTVNSTDSF-------------YQSRGLNNTFDT-FNNSYT------- -------------------SYDSYN-----------------------------SYDWN- -------------------------NTWINTTQTNDTWYNTWYNGWHNTSYH---TSFTS HNDTSITDQPSASSIAAAV----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGLHD------------------------------------ ----------------PT------------------------------------------ ------------------------------------------------------------ -----------------------------------------TTA---------------- -P-----G---------SFSVFNLTSLRYEDLTTS----------------A-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SG------LRGM-EV------------------------ --------------TFPCTGTYPCLDTFEGAIYNLTNEPHSRGGLNQDEGS--HWHVL-- --L------------------------------------------------------LL- LV-------VV--AGITGNVLVCIA------------------V------S--------- ---I-------------------------------------E-----K----K------- --------L--------------------------------------------------- ----------------Q------------N---------V-TN------Y-FLVSLAVAD LFVSLVV-------------------------------------------------MPCS ----------------------------------I------VHE-L-V---------G-- ---------------------------Y-----W-------------------------- ------------------P--------F-------------------------------- ----------------------------G----LV-M----CD-IWQV------------ --------T-DVMMCTS-------------SIMHMCTISLDR------------------ ------------------------------------------------------------ -------------------------------------------------YIA--I-R--- -H------P-L-K-V--------R---N-------K----S-R----------------- T-V----VGIKIATVWVISLAI-A-SPII---LL--SL----------------L----- N----------------------P------------------------ENV--------- ----------------------LH-----------------------------G------ ------------------------------------------------------------ --------G---------D------------CA--------------------------- ------------------------------------------------------------ -----------------------------------------I------------------ -----------------F---------------N-Q---Y-----FL------------- -----------IY-GS-----LAAFFIPLLLM------LIAYSLTIH------------- --------------------------IL----H------------------K-------- -----------------------Q--------A------------KLCAKKSKYGA---- --------------PMMRRS---------------------------------------- -----------------------T---------------SRRQK-RTKRSSQMTE----- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TQE ITDNHEKHEKQTASNGLRLAR--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---KIQSHLDRNKATPSEREPLARSR-----------------PDGA------------- ---------------------------------------------ETDA---SPSPLIAR L------------------------------------------------RAVKAEDSGNG TSVQVVKRGEGGL----------------------------------------------- ---------------------------------------------RGDGGPRLQALVKKH S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AAIK------------------------------ ----------------------------------VAGILI-------------------- --AKRQEN----------------EK---------------------------------- ---------------N-------------Q----------------L------------- -----------N----------------------------N------------------- -V------K-----------T---ER---K-----------------------AV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KVL---GTMFGTFVLC-- ---------W-----GPFFSLN---------------------------FAM-G------ ----------------------------V---C--------N--S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------C----------------------N ------I---------------E---V--------------T-LF--------------- ------------------------K-VFLW------------------------------ ---------CGY------------------------------------------------ --------------VSSTL-NP-----IIY---------TV------------------- --------------------------------------F--------------------- -------------------------NK-----T-----------------------F--- --------------------K-------------------------------------KT -------------F-------------------I-------------------------- --------------------------------------Q--------------------- --------------------L-------------L------------------------- -----------R------------------------------------------------ -----------------------------C------------------------------ -RC-------------------TAEDS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QPVTYTSANG--------------------------------------------- ------------------------------------------------------------ ----------------------------------------TSLRVKYDQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------QVSA---------- ---------------------------STNESMV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__Q8IS44__DRD2L__Dopamine_D2-like_Dop2R ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MLSPFDWR---R----G--- ------------ISSSGTGGT----------------------M---------------- ---------------------------AAQPLS--------------------------- ------------------------------------------------------------ -----STAATTAAATGATAATA-------------ATA---------------------- --------------------------------------------ATTSATLSTA------ ------------------------------------------AASTSTTAAPSAGAT--- -----------WINH-HLAVEAD-SSQPANGSDAQAGV-------EGPTMP--AGYLPLY EDVETAAEDAGYALIDDISEWLLGSVGS--EAAVGGPENSTNLAVTGANGTLAWL----- EALNSTQP----------AQSNSSAEDGER---------GRYSL---------RSFVEQQ LAGGGAAGAGDGGDAGIALIDSGEEAALDNVADAETDY--GMLGGFGDAELLQRTATVAR ETLGNRTAPSTTSYDGGGSGDV-------------------------------------- ---GVAG----------------------------------------------------- ---------------------GLAGTAGG------------------------------- --------------GVGGAGGSGGSTFMLLLE-----------NFND------------- --------------YFPNYNG--------S------------------------------ ------------------------------------------------------------ ------------------------------TVSGT-----STIA---------------- -PGVAITGSRG---------SGLLLE-------QNLTGLYLDGYRLNCTNETL-NLTDS- -----C------------------------------------------------------ ------------------------------------------------------------ -----G---------------E-------LR----V------------------------ -------------------------------VDH-------------------NYWAL-- --I------------------------------------------------------LI- LF-------PI--LTLFGNILVILS------------------V------C--------- ---R-------------------------------------E-----R----S------- --------L--------------------------------------------------- ----------------Q------------T---------V-TN------Y-FIVSLAIAD LLVAVVV-------------------------------------------------MPFA ----------------------------------V------YFL-V-N---------G-- ---------------------------A-----W-------------------------- ------------------A--------L-------------------------------- ----------------------------P----DV-V----CD-FYIA------------ --------M-DVICSTS-------------SIFNLVAISIDR------------------ ------------------------------------------------------------ -------------------------------------------------YIA--V-T--- -Q------P-I-K-Y--------A---K-------H--K-N-S----------------- R-R----VCLTILLVWAISAAI-G-SPIV----L--GL--N-------------N----- T----------------------P------------------------NR---------- -----------------------------------------------------E------ ---------------------------------------------------P-------- --------D---------V------------CA--------------------------- ------------------------------------------------------------ -----------------------------------------F------------------ -----------------Y---------------N-A---D-----FI------------- -----------LY-SS-----LSSFYIPCIIM------VFLYWNIFK------------- --------------------------AL----R------------------S-------- -----------------------R--------A------------R-------------- --------------KQ-------------------------------------------- ---------------------------------------RAARK-PHLSELTGGSVIENI ------------------------------------------------------------ ---------AQTR---------------RL---------AETALDSSRHASR-------- ---------------------------------------------------ILPDEAATN TASGSNEEEDENAISPDID----------------------------------------- --DCHVIVN-------------D------------------------------------- ---KSTEFMLATVVEETGNSVVAQITT--------------------------------Q PQLVVADPNGNHDSGYAASNVDDVLAGVAP-----------ASASAATS----------- --------------------------------AAPRS----------------------- ----------------------------------------------SGSPPDSPLPSGAT LQRSSVSSQRRP------------------------------------------------ ----------------------------------------TGDDSPKRGEPALRSVGVDN S----------------------------------------------------------- -----------------------------------------SVAMKPL------------ ---------SFVRYGVQEAMTLARNDSTLSTTSKTSSRKDK------------------- ----------------------------------------KNSQ---------------- --------------------------------ASRFTIYK-------------------- --VHKASK----------------KK---------------------------------- ---------------R-------------E----------------K------------- -----------S----------------------------S------------------- -A------K-----------K---ER---K-----------------------AT----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KTL---AIVLGVFLFC-- ---------W-----LPFFSCN---------------------------IMD-A------ ----------------------------M---C--------A--K--FK----------- ------------------------------------------------------------ -----------------------------------------------KD----------- ------------------------------------C----------------------R ------P---------------G---L--------------T-AY--------------- ------------------------M-MTTW------------------------------ ---------LGY------------------------------------------------ --------------INSFV-NP-----VIY---------TI------------------- --------------------------------------F--------------------- -------------------------NP-----E-----------------------F--- --------------------R-------------------------------------KA -------------F-------------------K-------------------------- --------------------------------------K--------------------- --------------------I-------------M------------------------- -----------HMG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------- >Outgrp_Bilateria_Drosophila_sp__Q4LBB6__OCTB3__Octopamine_beta-3R_Octbeta3R ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------M-S-------------G--- ------------VNVAD--------------------------L---------------- ------LA-----------------TTMTLPITAA------------------------- ------------------------------------------------------------ ---AGAATSQAAATSATNAS---------------------------------------- --------------------------------------------HLQPATLT-------- ------------------GH-------------------ISTTAAAKTTTTPTS------ -------------------------------------------------------SLPIT SQF----------------------VD--------------------ASLT--------- ----------------------SLSL---------------------------------- ------------------------------------------------------------ ----TATSSDASYSSPFSSYLS----------------------------SDST------ --FELLS----------------------------------------------------- ------------------------------------------------------------ ------------------TVG--------------------------------------- ----------------PNIT---------A------------------------------ NGSDIA------------------------------------------------------ --------------------------VDN-QA---------ELEE--------------- -S-------------------WLDL--------------------------S-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L--------L----L------------------------ -------------------------------L-----------------------KGF-- --I------------------------------------------------------FS- SI-------IL--AAVLGNALVIIS------------------V------Q--------- ---R-------------------------------------N-----R----K------- --------L--------------------------------------------------- ----------------R------------V---------I-TN------Y-FVVSLAMAD MLVALCA-------------------------------------------------MTFN ----------------------------------A------SVE-L-S----G----G-- ---------------------------K-----W-------------------------- ------------------M--------F-------------------------------- ----------------------------G----PF-M----CN-VYNS------------ --------L-DVYFSTA-------------SILHLCCISVDR------------------ ------------------------------------------------------------ -------------------------------------------------YYA--I-V--- -R------P-L-E-Y--------P---L-------N--M-T-H----------------- K-T----VCFMLANVWILPALI-S-FTPI---FL--GW--Y-------------T----- T----------------------E------------------------EH---------- --------------------------------LREISL---------------H------ ---------------------------------------------------P-------- --------D---------Q------------CS--------------------------- ------------------------------------------------------------ -----------------------------------------F------------------ -V---------------V---------------N-K---A-----YA------------- -----------LI-SS-----SVSFWIPGIVM------LVMYWRIFK------------- --------------------------EA----I------------------R-------- -----------------------Q--------R------------K-------------- --------------AL-------------------------------------------- ---------------------------------------SRTSS-NILLNSVHMGHTQQ- ---------------PTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRD ECDELRVPSPPPR-RLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPA PVFNPQIWTE--------------------------GKMIPSKELDKEHSHPNGPQQQLS LTSGSGNSEPEPESTAYRVFGGLNSDESE-GNDLYDTHLPLAEDNKELKRLIEDNYLYFK RQTGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQP VPGKEKGFNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGG KERKLERRQRQHSDTDSTPNKPDILLDINV----------LSEQSGASVIQQFSDGVQLI DFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEPSGLLIASSSELAE I----------FRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGA MDSSASSNAQSASINVYFL---------SPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVP VPQPNPQMASQSNISPKPEIIL----DSTLSPVEGC-----GDEHRDVTSPLFKRKDSAG DADVSVSGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSD SRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLP KCPLCGADISSTTGTTANATATANADSTIDTTVTTSS----------------------- ------------------------------------------------------------ ----------------------------------KRSIHEQT--P-----------DLGQ RPASSSSSTRFWH-----------KR----T--AAVTA---------------------- -CWQ------QSKNRK-------------R----------------R--FK--------- ----T----GCSHCGA---------------------TGGS------------------- -VRPAKGWK-----------A---EH---K-----------------------AA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RTL---GIIMGVFLLC-- ---------W-----LPFFLWY---------------------------VIT-S------ ----------------------------L---C--------G--P---A----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------C----------------------P ------C---------------P---D--------------V-LV--------------- ------------------------V-VLFW------------------------------ ---------IGY------------------------------------------------ --------------FNSTL-NP-----LIY---------AY------------------- --------------------------------------F--------------------- -------------------------NR-----D-----------------------F--- --------------------R-------------------------------------EA -------------F-------------------R-------------------------- --------------------------------------N--------------------- --------------------T-------------L------------------------- -----------E------------------------------------------------ -----------------------------CVLPCL------------------------- -EK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RNPYNA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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